PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2574975-3	1989	In the present study, it was found that the effects of the DA-acting drugs (apomorphine, LY 171555, SKF 38393, sulpiride, Sch 23390 and gamma-butyrolactone) on PKC activity were prevented by prior diminution of the endogenous stores of DA with alpha-methyl-p-tyrosine (alpha-MT) or reserpine.	Lysine	89-91	proline rich transmembrane protein 2	Homo sapiens	160-163
2604728-3	1989	The 10 nonactive-site lysine residues of rhodopsin can be reductively dimethylated to form permethylated rhodopsin (PMRh).	Lysine	22-28	rhodopsin	Homo sapiens	41-50
2604728-3	1989	The 10 nonactive-site lysine residues of rhodopsin can be reductively dimethylated to form permethylated rhodopsin (PMRh).	Lysine	22-28	rhodopsin	Homo sapiens	105-114
2604728-5	1989	The monomethylation of the active-site lysine residue of PMRh yields active-site-methylated rhodopsin (AMRh).	Lysine	39-45	rhodopsin	Homo sapiens	92-101
2628423-1	1989	Arg-42 or Lys-43 or Arg-44 of human pancreatic secretory trypsin inhibitor (PSTI) was replaced by Thr or Ser by site-directed mutagenesis, and the inactivation rates of the mutants after mixing with human trypsin were compared with that of the natural form.	Lysine	10-13	serine peptidase inhibitor Kazal type 1	Homo sapiens	36-74
2617455-4	1989	However, more lys- than glu-plasminogen bound when equal concentrations of either were added to immobilized fibrinogen.	Lysine	14-17	fibrinogen beta chain	Homo sapiens	108-118
2617455-8	1989	These studies demonstrate that immobilized fibrinogen binds both glu- and lys-plasminogen and that binding is mediated via lysine-binding regions.	Lysine	123-129	fibrinogen beta chain	Homo sapiens	43-53
2600080-5	1989	The COOH-terminal sequence of the high affinity Ca2+-binding protein, Lys-Asp-Glu-Leu, is the same as that proposed to be an endoplasmic reticulum retention signal (Munro, S., and Pelham, H. R. B.	Lysine	70-73	calreticulin	Oryctolagus cuniculus	34-68
2550439-5	1989	Derivatized PTH molecules which contained a single biotin at either lysine 13, lysine 26, or lysine 27 possessed full biological activity.	Lysine	68-74	parathyroid hormone	Homo sapiens	12-15
2558718-7	1989	Ligand-binding studies confirm that t-PA kringle 2 binds L-lysine with an association constant Ka approximately 11.9 mM-1.	Lysine	57-65	plasminogen activator, tissue type	Homo sapiens	36-40
2558718-8	1989	The data indicate that homologous or conserved residues relative to those that compose the lysine-binding sites of PGN kringles 1 and 4 are involved in the binding of L-lysine to t-PA kringle 2.	Lysine	91-97	plasminogen activator, tissue type	Homo sapiens	179-183
2558718-8	1989	The data indicate that homologous or conserved residues relative to those that compose the lysine-binding sites of PGN kringles 1 and 4 are involved in the binding of L-lysine to t-PA kringle 2.	Lysine	167-175	plasminogen activator, tissue type	Homo sapiens	179-183
2558718-13	1989	Several labile NH protons of t-PA kringle 2 exhibit retarded H-exchange kinetics, requiring more than a week in 2H2O for full deuteration in the presence of L-lysine at 37 degrees C. This reveals that kringle 2 is endowed with a compact, dynamically stable conformation.	Lysine	157-165	plasminogen activator, tissue type	Homo sapiens	29-33
2808341-5	1989	Chromatography of intact biotinylated rIL-1 beta by C4 reverse phase HPLC resolved a protein modified exclusively at the N-terminal alanine from two proteins modified singly at either lysine 93 or lysine 94.	Lysine	184-190	interleukin 1 beta	Rattus norvegicus	38-48
2808341-5	1989	Chromatography of intact biotinylated rIL-1 beta by C4 reverse phase HPLC resolved a protein modified exclusively at the N-terminal alanine from two proteins modified singly at either lysine 93 or lysine 94.	Lysine	197-203	interleukin 1 beta	Rattus norvegicus	38-48
2808341-6	1989	In addition, a protein product modified at lysine 103 was also obtained when rIL-1 beta was similarly modified with sulfo-NHS-biotin.	Lysine	43-49	interleukin 1 beta	Rattus norvegicus	77-87
2557906-1	1989	Cytochrome c derivatives labeled at specific lysine amino groups with ruthenium bis(bipyridine) dicarboxybipyridine [RuII(bpy)2(dcbpy)] were prepared by using the procedure described previously [Pan, L. P., Durham, B., Wolinska, J., & Millett, F. (1988) Biochemistry 27, 7180-7184].	Lysine	45-51	cytochrome c, somatic	Homo sapiens	0-12
2506177-0	1989	Fluorescein isothiocyanate specifically modifies lysine 338 of cytochrome P-450scc and inhibits adrenodoxin binding.	Lysine	49-55	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	63-82
2506177-4	1989	The modification of lysine 338 with FITC resulted in 85 +/- 15% inhibition of adrenodoxin binding to cytochrome P-450scc.	Lysine	20-26	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	101-120
2550439-5	1989	Derivatized PTH molecules which contained a single biotin at either lysine 13, lysine 26, or lysine 27 possessed full biological activity.	Lysine	79-85	parathyroid hormone	Homo sapiens	12-15
2550439-5	1989	Derivatized PTH molecules which contained a single biotin at either lysine 13, lysine 26, or lysine 27 possessed full biological activity.	Lysine	79-85	parathyroid hormone	Homo sapiens	12-15
2550439-10	1989	However, biotinylation of all three lysines results in a biologically inert PTH derivative and suggests that changes in isoelectric point, hydrophobicity, or tertiary structure may strongly influence hormone function.	Lysine	36-43	parathyroid hormone	Homo sapiens	76-79
2769258-7	1989	Finally, it was found that the C-terminal lysine residue of prepro-VIP is not removed during processing.	Lysine	42-48	vasoactive intestinal peptide	Homo sapiens	60-70
2550480-1	1989	Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues.	Lysine	142-148	transforming growth factor beta 1	Homo sapiens	0-38
2550480-1	1989	Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues.	Lysine	142-148	transforming growth factor beta 1	Homo sapiens	40-50
2550480-1	1989	Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues.	Lysine	142-148	transforming growth factor beta 1	Homo sapiens	105-115
2678107-2	1989	We now find that activity also resides in (i) the C-terminal tridecapeptide of PF4 (P13S), (ii) an analog of this in which arginine replaces the lysine residues and in which the last two amino acids are absent, (iii) the C-terminal 18 amino acids of low-affinity platelet factor 4, which is very similar to P13S, and (iv) peptide fragments of P13S that contain only 5-9 amino acids.	Lysine	145-151	platelet factor 4	Mus musculus	79-82
2674116-7	1989	This sulfur-free signal peptide analog can be labeled with 125I on the C-terminal D-tyrosine and is cleaved by purified hen oviduct signal peptidase between Gly and Lys, the correct site of cleavage of preproparathyroid hormone in vivo.	Lysine	165-168	parathyroid hormone	Homo sapiens	202-227
2819041-2	1989	Reaction conditions leading to the modification level of 0.82 and 2.85 PLP-Lys residues per cytochrome P-450scc molecule resulted in 60% and 98% inhibition, respectively, of electron-transfer rate from adrenodoxin to cytochrome P-450scc (with beta-NADPH as an electron donor via NADPH-adrenodoxin reductase and with phenyl isocyanide as the exogenous heme ligand of the cytochrome).	Lysine	75-78	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	92-111
2510823-0	1989	Binding of tissue-type plasminogen activator to lysine, lysine analogues, and fibrin fragments.	Lysine	48-54	plasminogen activator, tissue type	Homo sapiens	11-44
2510823-0	1989	Binding of tissue-type plasminogen activator to lysine, lysine analogues, and fibrin fragments.	Lysine	56-62	plasminogen activator, tissue type	Homo sapiens	11-44
2510823-2	1989	The binding of t-PA to lysine-Sepharose and aminohexyl-Sepharose was found to require kringle 2.	Lysine	23-29	plasminogen activator, tissue type	Homo sapiens	15-19
2510823-3	1989	The affinity for binding the lysine derivatives 6-aminohexanoic acid and N-acetyllysine methyl ester was about equal, suggesting that t-PA does not prefer C-terminal lysine residues for binding.	Lysine	29-35	plasminogen activator, tissue type	Homo sapiens	134-138
2510823-3	1989	The affinity for binding the lysine derivatives 6-aminohexanoic acid and N-acetyllysine methyl ester was about equal, suggesting that t-PA does not prefer C-terminal lysine residues for binding.	Lysine	81-87	plasminogen activator, tissue type	Homo sapiens	134-138
2766931-0	1989	A human tRNA gene cluster encoding the major and minor valine tRNAs and a lysine tRNA.	Lysine	74-80	mitochondrially encoded tRNA glycine	Homo sapiens	8-12
2520246-1	1989	Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side-products, including a component 12 Da higher in mass.	Lysine	122-125	renin	Homo sapiens	55-60
2765563-8	1989	A synthetic peptide Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys, the amino acid sequence of which corresponds to that surrounding hypusine in eukaryotic initiation factor 4D, was found to display competitive-type inhibition (Ki, 0.44 +/- 0.02 mM) against deoxyhypusine hydroxylase from Chinese hamster ovary cells.	Lysine	20-23	deoxyhypusine hydroxylase	Cricetulus griseus	257-282
2765563-8	1989	A synthetic peptide Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys, the amino acid sequence of which corresponds to that surrounding hypusine in eukaryotic initiation factor 4D, was found to display competitive-type inhibition (Ki, 0.44 +/- 0.02 mM) against deoxyhypusine hydroxylase from Chinese hamster ovary cells.	Lysine	62-65	deoxyhypusine hydroxylase	Cricetulus griseus	257-282
2504287-4	1989	In the presence of D-glucose, L-lysine stimulates insulin secretion to the same extent as L-arginine or L-ornithine, but the hormonal release is not further enhanced by combinations of these cationic amino acids.	Lysine	30-38	insulin	Homo sapiens	50-57
2697983-10	1989	Based on structural and mutational analysis, a model for human prorenin was built that suggests lysine -2 of the prosegment interacts with active site aspartate residues, and that the prosegment inactivation of renin is stabilized by binding of an amino terminal beta strand into a groove on renin.	Lysine	96-102	renin	Homo sapiens	66-71
2819041-2	1989	Reaction conditions leading to the modification level of 0.82 and 2.85 PLP-Lys residues per cytochrome P-450scc molecule resulted in 60% and 98% inhibition, respectively, of electron-transfer rate from adrenodoxin to cytochrome P-450scc (with beta-NADPH as an electron donor via NADPH-adrenodoxin reductase and with phenyl isocyanide as the exogenous heme ligand of the cytochrome).	Lysine	75-78	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	217-236
2502182-0	1989	Selective chemical modification of cytochrome P-450SCC lysine residues.	Lysine	55-61	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	35-54
2796989-7	1989	Changing an Asn residue to a Lys at the hypothetical cleavage site resulted in a PI-G-linked protein having a detectable alteration in electrophoretic mobility.	Lysine	29-32	stathmin 1	Mus musculus	81-85
2502182-2	1989	Selective chemical modification of cytochrome P-450SCC has been carried out with lysine-modifying reagents.	Lysine	81-87	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	35-54
2502182-8	1989	The major amino groups modified with radioactive succinic anhydride were found to be at Lys-73, -109, -110, -126, -145, -148 and -154 in the N-terminal sequence of cytochrome P-450SCC molecule and at Lys-267, -270, -338 and -342 in the C-terminal sequence.	Lysine	88-91	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	164-183
2508765-0	1989	[Study of the role of lysine residues of the cholesterol hydroxylating cytochrome P-450 by a method of chemical modification].	Lysine	22-28	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-87
2817813-15	1989	IFN alpha J and IFN-alpha 7 differ only by one amino acid, at position 107, where a lysine in IFN-alpha J has been replaced by a glutamic acid in the IFN-alpha 7.	Lysine	84-90	interferon alpha 1	Homo sapiens	0-9
2817813-15	1989	IFN alpha J and IFN-alpha 7 differ only by one amino acid, at position 107, where a lysine in IFN-alpha J has been replaced by a glutamic acid in the IFN-alpha 7.	Lysine	84-90	interferon alpha 1	Homo sapiens	16-25
2508765-3	1989	With a view of identifying lysine residues involved in the interaction with adrenodoxin, cytochrome P-450scc was modified by succinic anhydride in the presence of adrenodoxin.	Lysine	27-33	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	89-108
2508765-1	1989	Chemical modification of cytochrome P-450scc by lysine-specific reagents has been performed.	Lysine	48-54	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	25-44
2508765-7	1989	The role of lysine residues of cytochrome P-450scc in complex formation with adrenodoxin is discussed.	Lysine	12-18	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	31-50
2474353-8	1989	The non-immunological stimuli substance P, vasoactive intestinal peptide (VIP), somatostatin, compound 48/80, morphine and poly-L-lysine released similar amounts of histamine to anti-IgE, but 12 to 21 fold less PGD2 and LTC4.	Lysine	123-136	immunoglobulin heavy constant epsilon	Homo sapiens	183-186
2507457-1	1989	In an effort to synthesize potent vasopressin analogs containing photoreactive groups, we prepared, by solid phase synthesis, three analogs with proline or hydroxyproline substitutions in positions 4 and/or 7, lysine in positions 4 or 8, and beta-mercaptopropionic acid in position 1.	Lysine	210-216	arginine vasopressin	Rattus norvegicus	34-45
2753032-6	1989	We suggest that the N-terminal tetrapeptide, in particular lysine-4, is essential for the binding of human gastric lipase to lipid/water interfaces, and hence, for its physiological function.	Lysine	59-65	lipase F, gastric type	Homo sapiens	107-121
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Lysine	203-209	coagulation factor II, thrombin	Homo sapiens	136-144
2498336-0	1989	Dimerization and activation of porcine pancreatic phospholipase A2 via substrate level acylation of lysine 56.	Lysine	100-106	phospholipase A2 group IB	Homo sapiens	50-66
2666066-2	1989	The structure of mini-proinsulin is similar to that of proinsulin with a shortened C-peptide, B(1-29)-Ala-Ala-Lys-A(1-21) insulin.	Lysine	110-113	insulin	Homo sapiens	22-32
2666066-2	1989	The structure of mini-proinsulin is similar to that of proinsulin with a shortened C-peptide, B(1-29)-Ala-Ala-Lys-A(1-21) insulin.	Lysine	110-113	insulin	Homo sapiens	55-65
2666066-2	1989	The structure of mini-proinsulin is similar to that of proinsulin with a shortened C-peptide, B(1-29)-Ala-Ala-Lys-A(1-21) insulin.	Lysine	110-113	insulin	Homo sapiens	25-32
2503550-9	1989	Addition of methionine and lysine to a corn-based diet increased milk protein percentage and yield, plasma methionine and lysine concentrations, and increased yield of the casein proteins in milk.	Lysine	27-33	Weaning weight-maternal milk	Bos taurus	65-69
2503550-9	1989	Addition of methionine and lysine to a corn-based diet increased milk protein percentage and yield, plasma methionine and lysine concentrations, and increased yield of the casein proteins in milk.	Lysine	27-33	Weaning weight-maternal milk	Bos taurus	191-195
2568850-10	1989	Computer modeling of CAPP1-calmodulin with the X-ray coordinates of calmodulin (Babu et al., 1986) indicates that CAPP attached to Lys 75 cannot interact with the carboxyl-terminal phenothiazine-binding site.	Lysine	131-134	calmodulin 1	Homo sapiens	27-37
2568850-10	1989	Computer modeling of CAPP1-calmodulin with the X-ray coordinates of calmodulin (Babu et al., 1986) indicates that CAPP attached to Lys 75 cannot interact with the carboxyl-terminal phenothiazine-binding site.	Lysine	131-134	calmodulin 1	Homo sapiens	68-78
2539124-5	1989	Further proteolysis of the peptide with aminopeptidase and carboxypeptidase gave a compound which was identical to a product prepared from coupling of PQQ-DNPH to lysine.	Lysine	163-169	carboxypeptidase Q	Homo sapiens	40-54
2666264-3	1989	Amplification of the ppc gene in a C. glutamicum lysine-excreting strain resulted in increased PEPC-specific activity and lysine productivity.	Lysine	49-55	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	95-99
2725510-7	1989	However, PF4var1 had amino acid differences at three positions in the lysine-rich carboxy-terminal end that were all conserved among human, bovine, and rat PF4s.	Lysine	70-76	platelet factor 4 variant 1	Homo sapiens	9-16
2502319-9	1989	The present results show that t-PA and plasminogen form complexes with certain charge-modified BSAs via their lysine-binding sites.	Lysine	110-116	plasminogen activator, tissue type	Homo sapiens	30-34
2541779-5	1989	Isolated CNBr cleavage fragments of glycated calmodulin suggest that glycation follows a nonspecific pattern in that each of seven available lysines is susceptible to modification.	Lysine	141-148	calmodulin 1	Homo sapiens	45-55
2541779-9	1989	Examination of the lysine positions in calmodulin suggests that Ca2+ binding to domains II and IV is sufficient to induce these changes.	Lysine	19-25	calmodulin 1	Homo sapiens	39-49
2710782-4	1989	By analysis of the human alpha-thrombin:hirudin inhibition reaction in steady-state conditions it was shown that the dissociation constants for HV2(Lys-47) and HV2(Arg-47) were 5- to 14-fold lower than for unmodified HV2, whereas mutation of Lys-35 did not significantly alter the inhibition kinetics.	Lysine	148-151	coagulation factor II, thrombin	Homo sapiens	31-39
2537818-2	1989	In the presence of ascorbate N,N,N"N"-tetramethylphenylenediamine-cytochrome c as the electron donor, these fused membranes accumulated lysine but not ornithine or arginine under aerobic conditions.	Lysine	136-142	cytochrome c, somatic	Homo sapiens	66-78
2710782-4	1989	By analysis of the human alpha-thrombin:hirudin inhibition reaction in steady-state conditions it was shown that the dissociation constants for HV2(Lys-47) and HV2(Arg-47) were 5- to 14-fold lower than for unmodified HV2, whereas mutation of Lys-35 did not significantly alter the inhibition kinetics.	Lysine	242-245	coagulation factor II, thrombin	Homo sapiens	31-39
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Lysine	182-188	superoxide dismutase 1	Homo sapiens	31-57
2537662-2	1989	The derivatization of catalase resulted in coupling the long-chain fatty acyl residues to lysine, histidine and arginine, while other amino acids remained essentially unaffected.	Lysine	90-96	catalase	Rattus norvegicus	22-30
2536749-7	1989	Site-directed mutagenesis was then used to change the inefficiently recognized Lys-Lys potential cleavage site near the carboxyl terminus of beta-endorphin to Lys-Arg.	Lysine	79-82	proopiomelanocortin	Homo sapiens	141-155
2536749-7	1989	Site-directed mutagenesis was then used to change the inefficiently recognized Lys-Lys potential cleavage site near the carboxyl terminus of beta-endorphin to Lys-Arg.	Lysine	83-86	proopiomelanocortin	Homo sapiens	141-155
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Lysine	166-172	superoxide dismutase 1	Homo sapiens	116-124
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Lysine	182-188	superoxide dismutase 1	Homo sapiens	59-67
2493373-1	1989	Two mutants of interleukin-1 beta (K27C and K138C) were produced using site-specific mutagenesis in which lysine residues at positions 27 and 138 of the mature protein sequence were substituted by cysteine residues.	Lysine	106-112	interleukin 1 beta	Homo sapiens	15-33
2497771-15	1989	104, 579-586], we have shown the lysine binding site of t-PA kringle-2 to have a preference for a ligand with 8.8-A separation between amine and carboxylate functions.	Lysine	33-39	plasminogen activator, tissue type	Homo sapiens	56-60
2465762-1	1989	Cytosolic protein-tyrosine kinase from porcine spleen (CPTK-40) is strongly activated by poly-L-lysine using bovine serum albumin, ovalbumin, phosphorylase b, calmodulin and H1 histone as substrate proteins.	Lysine	89-102	calmodulin 1	Homo sapiens	159-169
2719939-12	1989	The enhanced enzymatic properties of ARH-I parallel a 2-fold increase in chemical reactivity of active-site lysine and histidine residues based on rates of chemical modification.	Lysine	108-114	low density lipoprotein receptor adaptor protein 1	Homo sapiens	37-40
2493374-2	1989	Arginine 115 in the subsite F of human lysozyme (peptidoglycan N-acetylmuramoylhydrolase, EC 3.2.1.17) was replaced with lysine, histidine, glutamine or glutamine acid by site-directed mutagenesis.	Lysine	121-127	lysozyme	Homo sapiens	39-47
2496749-5	1989	However, cleavage of wild-type t-PA into the two-chain form results in increased activity both on a peptide substrate and on the natural substrates Lys- and Glu-plasminogen in the absence or presence of stimulation by soluble fibrin.	Lysine	148-151	plasminogen activator, tissue type	Homo sapiens	31-35
2915986-4	1989	A kinase-negative mutant EGFR (K721A), in which Lys-721 in the ATp binding site was replaced by an alanine residue, was shown to be phosphorylated in an EGF-dependent manner by an enzymatically active EGFR deletion mutant lacking two autophosphorylation sites.	Lysine	48-51	epidermal growth factor receptor	Homo sapiens	25-29
2536706-6	1989	Bovine testes calmodulin was biotinylated on Lys-94 by calcium-dependent reaction with N-hydroxysuccinimido ester-biotin at pH 6.0.	Lysine	45-48	calmodulin	Bos taurus	14-24
2912171-2	1989	The infusion of lysine (LVP) or arginine (AVP) vasopressin into pigs and sheep, respectively, resulted in dose-dependent increases in plasma vasopressin concentration.	Lysine	16-22	vasopressin	Sus scrofa	141-152
2642907-6	1989	In rat liver, aspartyl-tRNA synthetase occurs in two distinct forms: a dimeric enzyme and a component of a multienzyme complex comprising the nine aminoacyl-tRNA synthetases specific for arginine, aspartic acid, glutamic acid, glutamine, isoleucine, leucine, lysine, methionine, and proline.	Lysine	259-265	aspartyl-tRNA synthetase 1	Rattus norvegicus	14-38
2540811-9	1989	These data indicate that (1), in the transition from rhodopsin to metarhodopsin II, major protein conformational changes are occurring near the lysine-retinal linkage whereas the ring portion of the chromophore remains deeply buried within the protein and (2) pigment absorptions characteristic of the metarhodopsin I and II states may be due to specific protein-chromophore interactions near the region of the chromophore ring.	Lysine	144-150	rhodopsin	Homo sapiens	53-62
2558924-8	1989	The singly PLP-modified cytochrome c indicate decreased activities with mitochondrial cytochrome c oxidase in the following order: PLP(Lys 86)-cyt.	Lysine	135-138	cytochrome c, somatic	Homo sapiens	24-36
2496037-7	1989	This region is identical between Lol p II and III, except for an Arg-Lys substitution, and could account, in part, for the DR3 association with responsiveness to both molecules.	Lysine	69-72	TNF receptor superfamily member 25	Homo sapiens	123-126
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Lysine	147-150	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Lysine	168-171	angiotensinogen	Homo sapiens	35-38
2558924-3	1989	The pKa values are 8.76 for cytochrome c modified by PLP at lysine 79[PLP(Lys 79)-cyt.	Lysine	60-66	cytochrome c, somatic	Homo sapiens	28-40
2558924-8	1989	The singly PLP-modified cytochrome c indicate decreased activities with mitochondrial cytochrome c oxidase in the following order: PLP(Lys 86)-cyt.	Lysine	135-138	cytochrome c, somatic	Homo sapiens	86-98
2558924-3	1989	The pKa values are 8.76 for cytochrome c modified by PLP at lysine 79[PLP(Lys 79)-cyt.	Lysine	74-77	cytochrome c, somatic	Homo sapiens	28-40
2509834-2	1989	Furthermore, calmodulin has been reported to have lysine residues which markedly increase their reactivity toward electrophilic substances in the calcium-loaded state.	Lysine	50-56	calmodulin 1	Homo sapiens	13-23
2494434-9	1989	The unique susceptibility of rat monoclonal IgG1 and IgG2a is likely to be the result of the presence of a lysine residue in a loop of C gamma 1 domain, which therefore is accessible to trypsin.	Lysine	107-113	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	44-48
2552247-4	1989	Tryptic mapping of nexly synthetized alpha-MSH generated two fragments with the following amino acid composition: (T1) Trp, Pro, Lys, Gly, Val and (T2) Tyr, Arg, Phe, His, Ser, Glu.	Lysine	129-132	proopiomelanocortin	Homo sapiens	37-46
2853949-3	1988	It is shown that at least 3 ubiquitin molecules can be coupled to calmodulin indicating that more than one lysine residue is involved in the ubiquitination reaction.	Lysine	107-113	calmodulin 1	Homo sapiens	66-76
2466482-1	1988	The conformation of reduced bovine pancreatic trypsin inhibitor (R-BPTI) under reducing conditions was monitored by measurements of nonradiative excitation energy-transfer efficiencies (E) between a donor probe attached to the N-terminal Arg1 residue and an acceptor attached to one of the lysine residues (15, 26, 41, or 46) [Amir, D., & Haas, E. (1987) Biochemistry 26, 2162-2175].	Lysine	290-296	trophoblast Kunitz domain protein 1	Bos taurus	46-63
2515532-1	1989	A major browning compound derived from lysine and glucose was purified by high performance chromatography on a RP8 column after several extractions in methanol plus acetonitrile.	Lysine	39-45	programmed cell death 2	Homo sapiens	111-114
2558379-3	1989	Further calculations suggest that these charge features of calmodulin can be selectively perturbed by changing clusters of phylogenetically conserved acidic amino acids in helices to lysines.	Lysine	183-190	calmodulin 1	Homo sapiens	59-69
2848832-0	1988	Effects of interaction with calcineurin on the reactivities of calmodulin lysines.	Lysine	74-81	calmodulin 1	Homo sapiens	63-73
3232124-2	1988	Time-course experiments established that the venom enzyme cleaves primarily the A alpha-chain of human fibrinogen and fibrin between the Lys-413 and Leu-414 position.	Lysine	137-140	Fc gamma receptor and transporter	Homo sapiens	82-93
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Lysine	49-52	calmodulin 1	Homo sapiens	224-234
3141214-0	1988	Identification of lysine residue 199 of human serum albumin as a binding site for benzylpenicilloyl groups.	Lysine	18-24	albumin	Homo sapiens	46-59
2462252-1	1988	Cop 1 is a synthetic basic random copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine in a residue molar ratio of 6.0:1.9:4.7:1.0 and with a molecular weight of 21,000 which proved to be effective in specific suppression of experimental allergic encephalomyelitis and has been proposed as a candidate drug against multiple sclerosis.	Lysine	75-83	COP1 E3 ubiquitin ligase	Homo sapiens	0-5
3182816-5	1988	The triglyceride content of LDL was found to be reciprocally related to the number of free lysine amino groups of LDL apolipoprotein B (apoB) which could be labeled with trinitrobenzenesulfonic acid.	Lysine	91-97	apolipoprotein B	Homo sapiens	118-134
3182816-5	1988	The triglyceride content of LDL was found to be reciprocally related to the number of free lysine amino groups of LDL apolipoprotein B (apoB) which could be labeled with trinitrobenzenesulfonic acid.	Lysine	91-97	apolipoprotein B	Homo sapiens	136-140
3182816-6	1988	13C-Nuclear magnetic resonance (NMR) spectra of native LDL and HL-LDL samples containing [13CH3]2 lysine residues formed by reductive methylation (11-13% modification) showed that the arrangement of apoB lysines is perturbed by the exposure to hepatic lipase.	Lysine	204-211	apolipoprotein B	Homo sapiens	199-203
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Lysine	25-28	calmodulin 1	Homo sapiens	224-234
2844821-7	1988	It is concluded that Ser-Lys-Thr-Ala-Ser-Pro-Trp-Lys-Ser-Ala-Arg-Leu-Met-Val-His-Thr-Val-Ala- Thr- Phe-Asn-Ser-Ile-Lys, a 24-residue peptide which bridges repeats 11 and 12 of brain alpha spectrin contains the high affinity calmodulin binding domain.	Lysine	49-52	calmodulin 1	Homo sapiens	224-234
3417681-5	1988	A lysine residue to thrombin was essential for its binding to fibrinogen.	Lysine	2-8	coagulation factor II, thrombin	Homo sapiens	20-28
3233203-4	1988	Group-specific modification of either arginine, lysine, or histidine residues of bindin results in a substantial inactivation of fucan binding activity.	Lysine	48-54	bindin	Strongylocentrotus purpuratus	81-87
3178877-6	1988	Localization of the MLD binding site on bee venom PLA2 demonstrated that upon MLD modification of bee venom PLA2 the only change in amino acid content was an apparent loss of Lys, corresponding to approximately three of the eleven Lys residues present.	Lysine	175-178	phospholipase A2 group IB	Homo sapiens	50-54
3178877-6	1988	Localization of the MLD binding site on bee venom PLA2 demonstrated that upon MLD modification of bee venom PLA2 the only change in amino acid content was an apparent loss of Lys, corresponding to approximately three of the eleven Lys residues present.	Lysine	175-178	phospholipase A2 group IB	Homo sapiens	108-112
3178877-6	1988	Localization of the MLD binding site on bee venom PLA2 demonstrated that upon MLD modification of bee venom PLA2 the only change in amino acid content was an apparent loss of Lys, corresponding to approximately three of the eleven Lys residues present.	Lysine	231-234	phospholipase A2 group IB	Homo sapiens	50-54
3178877-6	1988	Localization of the MLD binding site on bee venom PLA2 demonstrated that upon MLD modification of bee venom PLA2 the only change in amino acid content was an apparent loss of Lys, corresponding to approximately three of the eleven Lys residues present.	Lysine	231-234	phospholipase A2 group IB	Homo sapiens	108-112
3178877-7	1988	Selective chemical modification of Lys residues with [14C]maleic anhydride demonstrated that all eleven Lys residues on bee venom PLA2 were accessible to this reagent (11.6 mol maleyl group incorporated/mol of PLA2).	Lysine	35-38	phospholipase A2 group IB	Homo sapiens	130-134
3178877-7	1988	Selective chemical modification of Lys residues with [14C]maleic anhydride demonstrated that all eleven Lys residues on bee venom PLA2 were accessible to this reagent (11.6 mol maleyl group incorporated/mol of PLA2).	Lysine	104-107	phospholipase A2 group IB	Homo sapiens	130-134
3178877-8	1988	Pretreatment of PLA2 with MLD (less than 0.7% residual activity) resulted in a molar ratio of 8.7, also consistent with the loss of three Lys residues upon modification by MLD.	Lysine	138-141	phospholipase A2 group IB	Homo sapiens	16-20
3178877-13	1988	The control carboxymethylated-PLA2 fragment corresponding to residues 81-128 sequenced beyond Lys-88 without significant change in the expected yield.	Lysine	94-97	phospholipase A2 group IB	Homo sapiens	30-34
2849987-1	1988	A novel two-step procedure has been developed to prepare cytochrome c derivatives labeled at specific lysine amino groups with ruthenium bis(bipyridine) dicarboxybipyridine [RuII(bpy)2(dcbpy)].	Lysine	102-108	cytochrome c, somatic	Homo sapiens	57-69
2849987-2	1988	In the first step, cytochrome c was treated with the mono-N-hydroxysuccinimide ester of 4,4"-dicarboxy-2,2"-bipyridine (dcbpy) to convert positively charged lysine amino groups to negatively charged dcbpy-lysine groups.	Lysine	157-163	cytochrome c, somatic	Homo sapiens	19-31
2849987-2	1988	In the first step, cytochrome c was treated with the mono-N-hydroxysuccinimide ester of 4,4"-dicarboxy-2,2"-bipyridine (dcbpy) to convert positively charged lysine amino groups to negatively charged dcbpy-lysine groups.	Lysine	205-211	cytochrome c, somatic	Homo sapiens	19-31
2844937-2	1988	Aa a plasma marker of an endothelial abnormality, the serum activity of angiotensin-converting enzyme (ACE) was investigated at rest and after stimulation either by local venostasis or infusion of an analogue of lysine-vasopressin (desmopressin acetate).	Lysine	212-218	angiotensin I converting enzyme	Homo sapiens	72-101
2844937-2	1988	Aa a plasma marker of an endothelial abnormality, the serum activity of angiotensin-converting enzyme (ACE) was investigated at rest and after stimulation either by local venostasis or infusion of an analogue of lysine-vasopressin (desmopressin acetate).	Lysine	212-218	angiotensin I converting enzyme	Homo sapiens	103-106
2844937-2	1988	Aa a plasma marker of an endothelial abnormality, the serum activity of angiotensin-converting enzyme (ACE) was investigated at rest and after stimulation either by local venostasis or infusion of an analogue of lysine-vasopressin (desmopressin acetate).	Lysine	212-218	arginine vasopressin	Homo sapiens	219-230
3138240-0	1988	A 13C NMR characterization of lysine residues in apolipoprotein B and their role in binding to the low density lipoprotein receptor.	Lysine	30-36	apolipoprotein B	Homo sapiens	49-65
3138240-1	1988	NMR spectroscopy of 13C-labeled human low density lipoprotein (LDL) has been employed to characterize the lysine (Lys) residues in apo B-100.	Lysine	106-112	apolipoprotein B	Homo sapiens	131-140
3138240-1	1988	NMR spectroscopy of 13C-labeled human low density lipoprotein (LDL) has been employed to characterize the lysine (Lys) residues in apo B-100.	Lysine	114-117	apolipoprotein B	Homo sapiens	131-140
3138240-7	1988	The relative involvement of active and normal Lys in binding of apo B-100 to the LDL receptor on fibroblasts was explored by measuring the decrease in receptor binding as a function of the degree of methylation of the two types of Lys.	Lysine	46-49	apolipoprotein B	Homo sapiens	64-73
3138240-8	1988	Upper limits of 21 active and 31 normal Lys in the entire apo B-100 molecule are involved in the binding of LDL to the receptor.	Lysine	40-43	apolipoprotein B	Homo sapiens	58-67
3417681-5	1988	A lysine residue to thrombin was essential for its binding to fibrinogen.	Lysine	2-8	fibrinogen beta chain	Homo sapiens	62-72
2843239-0	1988	The secondary structure of apolipoproteins in human HDL3 particles after chemical modification of their tyrosine, lysine, cysteine or arginine residues.	Lysine	114-120	apolipoprotein E	Homo sapiens	27-42
3417645-4	1988	We found that the alpha chain tetrapeptide, Arg-Gly-Asp-Ser (RGDS), and the gamma chain peptide, Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (LGGAKQAG-DV), each inhibited fibrinogen binding to ADP-stimulated platelets with Ki values of 15.6 +/- 2.7 and 46.2 +/- 8.2 microM, respectively.	Lysine	113-116	fibrinogen beta chain	Homo sapiens	167-177
3138990-1	1988	The active centre of NADPH-cytochrome P-450 reductase contains the lysine residue essential for catalytic activity.	Lysine	67-73	cytochrome p450 oxidoreductase	Homo sapiens	21-53
2843239-0	1988	The secondary structure of apolipoproteins in human HDL3 particles after chemical modification of their tyrosine, lysine, cysteine or arginine residues.	Lysine	114-120	HDL3	Homo sapiens	52-56
2843239-4	1988	Modification of HDL3 by tetranitromethane (TNM) treatment, acetylation, reduction plus alkylation and 1,2-cyclohexanedione treatment derivatised tyrosine, lysine, cysteine and arginine residues, respectively, and caused alteration of the secondary structure of the HDL3 apolipoproteins to different extents.	Lysine	155-161	HDL3	Homo sapiens	16-20
2464382-11	1988	The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE.	Lysine	220-233	tachykinin precursor 1	Homo sapiens	4-15
3137974-0	1988	Immobilized colipase affinities for lipases B, A, C and their terminal peptide (336-449): the lipase recognition site lysine residues are located in the C-terminal region.	Lysine	118-124	colipase	Sus scrofa	12-20
3137974-7	1988	In particular, guanidination of lysine residues of both peptide and isolipase B led to the loss of interactions with colipase.	Lysine	32-38	colipase	Sus scrofa	117-125
3137220-5	1988	A second modified calmodulin was generated by cleaving the central helix of the cross-linked protein at Lys-77 with trypsin.	Lysine	104-107	calmodulin 1	Homo sapiens	18-28
2464382-11	1988	The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE.	Lysine	220-233	tachykinin precursor 1	Homo sapiens	78-89
2464382-11	1988	The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE.	Lysine	220-233	vasoactive intestinal peptide	Homo sapiens	185-188
3240982-2	1988	The predominant amino acids in the phospholipase A2 were cysteine, glycine, arginine, and lysine, suggesting that it is a basic one.	Lysine	90-96	phospholipase A2 group IB	Homo sapiens	35-51
3143485-13	1988	The five genes, rpl23 (101 codons), rpl2 (278 codons), rps19 (95 codons), rpl22 (114 codons) and rps3 (220 codons) encode lysine-rich polypeptides with predicted molecular weights of 12,152, 31,029, 10,880, 12,819, and 25,238, respectively.	Lysine	122-128	rpl23	Euglena gracilis	16-21
3143485-13	1988	The five genes, rpl23 (101 codons), rpl2 (278 codons), rps19 (95 codons), rpl22 (114 codons) and rps3 (220 codons) encode lysine-rich polypeptides with predicted molecular weights of 12,152, 31,029, 10,880, 12,819, and 25,238, respectively.	Lysine	122-128	50S ribosomal protein L2	Euglena gracilis	16-20
3136156-2	1988	The site of calcium-dependent carbamoylation on calmodulin by the antineoplastic agent 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl CCNU) was determined to be Lys-75 as demonstrated using [ring-14C]methyl CCNU and sequence analysis of the sole labeled peptide obtained from tryptic digestion of reversed-phase high pressure liquid chromatography (HPLC)-purified radiolabeled calmodulin.	Lysine	177-180	calmodulin 1	Homo sapiens	48-58
3406746-5	1988	Further digestion removes a carboxyl-terminal fragment, including the pseudosubstrate sequence Ser484-Lys-Asp-Arg-Met-Lys-Lys-Tyr-Met- Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg505 and results in a calmodulin-independent 61-kD fragment.	Lysine	102-105	calmodulin 1	Homo sapiens	207-217
3136156-0	1988	Modification of calmodulin on Lys-75 by carbamoylating nitrosoureas.	Lysine	30-33	calmodulin 1	Homo sapiens	16-26
3136156-8	1988	We conclude that Lys-75 is not essential for the function of calmodulin but is in a region of the molecule involved in interaction with phosphodiesterase as well as the binding of certain hydrophobic calmodulin antagonists.	Lysine	17-20	calmodulin 1	Homo sapiens	200-210
2900006-0	1988	Beta-endorphin modification by transglutaminase in vitro: identification by FAB/MS of glutamine-11 and lysine-29 as acyl donor and acceptor sites.	Lysine	103-109	proopiomelanocortin	Homo sapiens	0-14
2461117-3	1988	Extensive use of fast atom bombardment mass spectrometry allowed to establish that: i) a 1:1 adduct Substance P-spermine is formed; ii) only a single glutamine residue out of two, i.e. Gln-5, acts as acyl donor, iii) the single lysine residue of the neuropeptide is unable to act as acyl acceptor.	Lysine	228-234	tachykinin precursor 1	Homo sapiens	100-111
2459270-1	1988	A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS).	Lysine	100-113	interferon alpha 1	Homo sapiens	27-37
2459270-1	1988	A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS).	Lysine	100-113	interferon alpha 1	Homo sapiens	39-42
3131325-3	1988	Analysis of amino acid composition revealed that CT14 was rich in lysine and proline residues, suggesting unique structure of microtubule-binding domain of tau proteins.	Lysine	66-72	sarcoma antigen 1	Homo sapiens	49-53
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Lysine	140-143	angiotensinogen	Homo sapiens	32-35
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Lysine	161-164	angiotensinogen	Homo sapiens	32-35
3131305-3	1988	Genetic studies indicated that the slp1-1 mutation (for small lysine pool) is recessive and is due to a single chromosomal mutation.	Lysine	62-68	Slp1p	Saccharomyces cerevisiae S288C	35-39
2966154-9	1988	Chemical modification of the lysine residues of apolipoprotein B (apoB) by either acetylation or acetoacetylation prevented or diminished the interaction of LDL2 with Lp(a), as shown by both agarose electrophoresis and ligand blotting using modified LDL2.	Lysine	29-35	apolipoprotein B	Homo sapiens	48-64
2966154-9	1988	Chemical modification of the lysine residues of apolipoprotein B (apoB) by either acetylation or acetoacetylation prevented or diminished the interaction of LDL2 with Lp(a), as shown by both agarose electrophoresis and ligand blotting using modified LDL2.	Lysine	29-35	apolipoprotein B	Homo sapiens	66-70
2966154-10	1988	Moreover, removal of the acetoacetyl group from the lysine residues of apoB by hydroxylamine reestablished the interaction of LDL2 with Lp(a).	Lysine	52-58	apolipoprotein B	Homo sapiens	71-75
2966154-12	1988	Based on these observations, it was concluded that Lp(a) interacts with LDL2 and other apoB-containing lipoproteins which are enriched in triglyceride; this interaction is due to the presence of apolipoprotein(a) and involves lysine residues of apoB interacting with the plasminogen-like domains (kringle 4) of apolipoprotein(a).	Lysine	226-232	apolipoprotein B	Homo sapiens	87-91
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	0-2
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
2898111-3	1988	BK-related peptides exhibited the following rank order of potency in this assay: BK = [Lys]BK greater than [Met-Lys]Bk much greater than [Des-Arg9]BK much greater than BK(1-6) = BK(2-7) = BK(2-9).	Lysine	87-90	kininogen 1	Homo sapiens	81-83
3373430-11	1988	Hydrophobic binding of these compounds to HSA at the warfarin site is possibly stabilized by the attraction of the delocalized negative charge to the basic lysine and arginine residues adjoining the lone tryptophan.	Lysine	156-162	albumin	Homo sapiens	42-45
2964446-9	1988	Thus synthesis and maturation of the alpha-chain of beta-hexosaminidase includes two major proteolytic cleavages: the first, between alanine 22 and leucine 23, removes the signal peptide to generate the precursor form, whereas the second occurs between the dibasic amino acids, lysine 86 and arginine 87.	Lysine	278-284	Fc gamma receptor and transporter	Homo sapiens	37-48
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Lysine	96-102	coagulation factor II, thrombin	Homo sapiens	37-45
2828688-7	1988	Nucleotide sequencing established that the C3H p110 provirus was integrated within the R region of an endogenous VL30 long terminal repeat (LTR) in reverse orientation and that the virus differed from the infectious AKR p623 provirus by a point mutation, substituting Lys for Arg at the potential precursor cleavage site for gp70 and p15E.	Lysine	268-271	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	47-51
2828688-11	1988	Substitution of Arg for Lys at the envelope precursor processing site of C3H p110 by site-directed mutagenesis is sufficient by itself to convert the virus to the XC-positive replication-competent phenotype.	Lysine	24-27	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	77-81
2968789-0	1988	Synthesis of lysine-containing sulphonium salts and their properties as proteinase inhibitors.	Lysine	13-19	endogenous retrovirus group K member 25	Homo sapiens	72-82
3134610-0	1988	[The role of epsilon-amino groups of lysine of human serum albumin in heat-induced protein denaturation.	Lysine	37-43	albumin	Homo sapiens	59-66
3134610-2	1988	Human serum albumin was glycosidated by prolonged protein incubation in phosphate buffer, pH 6.8-7.0, with excess glucose at 37 degrees C. epsilon-amino groups of lysine residues of the albumin molecule were alkylated by pyridoxal-5-phosphate in the presence of NaBH4.	Lysine	163-169	albumin	Homo sapiens	12-19
3394172-0	1988	[Binding of K 1-3 and K 4 fragments of plasminogen containing lysine-binding sites with fibrinogen and its fragments].	Lysine	62-68	fibrinogen beta chain	Homo sapiens	88-98
3134610-2	1988	Human serum albumin was glycosidated by prolonged protein incubation in phosphate buffer, pH 6.8-7.0, with excess glucose at 37 degrees C. epsilon-amino groups of lysine residues of the albumin molecule were alkylated by pyridoxal-5-phosphate in the presence of NaBH4.	Lysine	163-169	albumin	Homo sapiens	186-193
3394172-1	1988	Interaction of plasminogen K 1-3 and K 4 fragments containing lysine binding sites with fibrinogen and its fragments has been investigated.	Lysine	62-68	fibrinogen beta chain	Homo sapiens	88-98
3394172-5	1988	The results obtained indicate that lysine binding sites located at plasminogen K 1-3 and K 4 fragments correspond to different fibrinogen molecule centres.	Lysine	35-41	fibrinogen beta chain	Homo sapiens	127-137
3240339-4	1988	Concentrations of CFP-LI were 10-20% those of VIP-LI but could be increased 5-fold by digestion with carboxypeptidase B, suggesting that the C-terminal lysine residue of prepro VIP is not normally removed during processing.	Lysine	152-158	vasoactive intestinal peptide	Rattus norvegicus	177-180
3394172-6	1988	The centre complementary to K 4 fragment lysine binding sites could be located at the fibrinogen alpha C domain.	Lysine	41-47	fibrinogen beta chain	Homo sapiens	86-96
3422479-10	1988	The geometric change (the rhodopsin "photoswitch") resulting from cis-trans isomerization in the first excited electronic state (S1), ultimately leads to RX (photoactivated rhodopsin, metarhodopsin II) and changes the activity of exobilayer groups, possibly causing dissociation of Lys-83 and Arg-85 from the carboxylate groups at positions 263 and 265.	Lysine	282-285	rhodopsin	Homo sapiens	26-35
2964368-13	1988	Examination of these sequences reveals that Lys-84 is present in all the IFN-alpha except IFN-alpha B where it is replaced by Glu; and Tyr-90, present in most of the common IFN-alpha including alpha A and alpha D, is replaced by Asp in IFN-alpha B.	Lysine	44-47	interferon alpha 1	Homo sapiens	73-82
2964368-13	1988	Examination of these sequences reveals that Lys-84 is present in all the IFN-alpha except IFN-alpha B where it is replaced by Glu; and Tyr-90, present in most of the common IFN-alpha including alpha A and alpha D, is replaced by Asp in IFN-alpha B.	Lysine	44-47	interferon alpha 8	Homo sapiens	90-101
2964368-13	1988	Examination of these sequences reveals that Lys-84 is present in all the IFN-alpha except IFN-alpha B where it is replaced by Glu; and Tyr-90, present in most of the common IFN-alpha including alpha A and alpha D, is replaced by Asp in IFN-alpha B.	Lysine	44-47	interferon alpha 1	Homo sapiens	90-99
2855597-5	1988	Some of the bound peptides are evidently in relatively close proximity to each other since, in the presence of amidated (i.e., lysine-blocked) calmodulin, cross-linking yielded peptide dimers.	Lysine	127-133	calmodulin 1	Homo sapiens	143-153
3422479-10	1988	The geometric change (the rhodopsin "photoswitch") resulting from cis-trans isomerization in the first excited electronic state (S1), ultimately leads to RX (photoactivated rhodopsin, metarhodopsin II) and changes the activity of exobilayer groups, possibly causing dissociation of Lys-83 and Arg-85 from the carboxylate groups at positions 263 and 265.	Lysine	282-285	rhodopsin	Homo sapiens	173-182
3126814-0	1988	Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity.	Lysine	25-31	fibroblast growth factor 1	Mus musculus	44-75
2452461-4	1988	A second peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 isolated from the extracts is identical to human neurokinin A.	Lysine	21-24	tachykinin precursor 1	Homo sapiens	110-122
2826479-3	1988	The C-terminal region is lysine-rich and is necessary for mak11-complementing activity.	Lysine	25-31	PAK1 interacting protein 1	Homo sapiens	58-63
3126814-1	1988	Reductive methylation of bovine brain derived acidic fibroblast growth factor (aFGF) with formaldehyde and sodium cyanoborohydride reduces its capacity to stimulate mitogenesis in Balb/C 3T3 cells, and this correlates with the modification of less than 3 of its 12 lysine residues.	Lysine	265-271	fibroblast growth factor 1	Mus musculus	46-77
3126814-4	1988	Structural characterization of LA-aFGF using peptide mapping and sequencing procedures demonstrates that Lys-118 is the primary site of modification.	Lysine	105-108	fibroblast growth factor 1	Mus musculus	34-38
3122756-0	1988	Determination of the effect of acetylation of specific lysine residues in human growth hormone on its affinity for somatogenic receptors by an affinity selection technique.	Lysine	55-61	growth hormone 1	Homo sapiens	80-94
3126814-5	1988	The results indicate that in aFGF, Lys-118 plays an important role in heparin binding and suggest that this residue and its local environment are involved in the interaction of aFGF with both heparin and its cell surface receptor.	Lysine	35-38	fibroblast growth factor 1	Mus musculus	29-33
3126814-5	1988	The results indicate that in aFGF, Lys-118 plays an important role in heparin binding and suggest that this residue and its local environment are involved in the interaction of aFGF with both heparin and its cell surface receptor.	Lysine	35-38	fibroblast growth factor 1	Mus musculus	177-181
3275655-8	1988	By relating the NH2-terminal amino acid sequences of these peptides to the sequence of the intact egg-specific protein, the protease was shown to cleave first at a Lys-Asn site and secondly at Arg-Asp.	Lysine	164-167	egg-specific protein	Bombyx mori	98-118
3123231-2	1988	Several enzymes of the lysine pathway of Saccharomyces cerevisiae were found to respond to an induction mechanism mediated by the product of gene LYS14 in the presence of 2-aminoadipate semialdehyde, an intermediate of this pathway.	Lysine	23-29	Lys14p	Saccharomyces cerevisiae S288C	146-151
2840973-2	1988	We have isolated a pro-hormone converting enzyme from bovine neural and intermediate lobe secretory vesicles that cleaves pro-vasopressin and pro-opiomelanocortin at Lys-Arg residues to yield vasopressin, and adrenocorticotropin/endorphin-related peptides, respectively.	Lysine	166-169	proopiomelanocortin	Bos taurus	142-162
2826453-3	1988	Between 1 and 4 biotinyl residues were incorporated per human beta-endorphin molecule, at Lys-9, -19, -24, -28, and -29, but not at the amino-terminal Tyr-1.	Lysine	90-93	proopiomelanocortin	Homo sapiens	62-76
2826453-9	1988	Thus, when bound to avidin, the biotinylated human beta-endorphin derivatives with spacer arm (BX1 alpha), substituted near the carboxyl terminal (Lys-24, -28, and -29), displayed mu binding affinities equal to and delta binding affinities only four times lower than underivatized human beta-endorphin.	Lysine	147-150	proopiomelanocortin	Homo sapiens	51-65
3338452-5	1988	Cationic amino acid residues of hFABP (1 His, 15 Lys, 2 Arg) were screened for ionic fatty acid/protein interactions.	Lysine	49-52	fatty acid binding protein 3	Homo sapiens	32-37
2459027-2	1988	Preliminary results indicate, that lys (47) may be directly involved in the hirudin-thrombin interaction: 1.	Lysine	35-38	coagulation factor II, thrombin	Homo sapiens	84-92
2971533-7	1988	Fibrin-bound t-PA was found to exclusively activate plasminogen bound to certain internal lysine residues.	Lysine	90-96	plasminogen activator, tissue type	Homo sapiens	13-17
3145818-1	1988	Lysinoalanine [N epsilon-(DL-2-amino-2-carboxyethyl)-L-lysine; LAL], a nephrotoxic lysine analog, inhibits the lysyl-tRNA-synthetase (EC 6.1.1.6) of prokaryotic and eukaryotic cells competitively at micromolar concentrations.	Lysine	55-61	lysyl-tRNA synthetase 1	Homo sapiens	111-132
3141253-1	1988	A gap1 can1 mutant of Saccharomyces cerevisiae with a single lysine transport system remaining was used to study detailed kinetics of this transport.	Lysine	61-67	amino acid permease GAP1	Saccharomyces cerevisiae S288C	2-6
3144771-4	1988	It was concluded that high fibrin-binding affinity of t-PA and plasminogens were largely related to the lysine-binding affinity of these enzymes, but that of UK"s would be related to the other binding affinity.	Lysine	104-110	plasminogen activator, tissue type	Homo sapiens	54-58
3243375-9	1988	Ophiobolin A-treated calmodulin is resistant to tryptic cleavage at lysine 77.	Lysine	68-74	calmodulin	Bos taurus	21-31
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Lysine	219-222	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Lysine	219-222	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Lysine	219-222	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-38
2465527-4	1988	C-src variants encoding proteins with the alteration of arg 95 to trp, glu, or lys, or containing the deletion of residues 92-95, induced alterations in cell morphology and promoted growth in soft agar as well as changes in glucose transport and in vivo tyrosine phosphorylation of cellular proteins (including calpactin I heavy chain, p36).	Lysine	79-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
3426593-4	1987	The pyridoxal 5"-phosphate-binding site has the His-Lys(PLP)-X structure characteristic of known pyridoxal 5"-phosphate-dependent amino acid decarboxylases, tryptophan synthase, and serine hydroxymethyltransferase.	Lysine	52-55	proteolipid protein 1	Gallus gallus	56-59
3118957-10	1987	The effect of phenylglyoxal on aldose reductase may be explained by the modification of a reactive thiol or lysine rather than an arginine residue.	Lysine	108-114	aldo-keto reductase family 1 member B	Homo sapiens	31-47
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
3427089-10	1987	The heparin-HRG interaction is progressively decreased by modification of the histidine residues of HRG, whereas modification of 22 of the 33 lysine residues of HRG has little effect.	Lysine	142-148	histidine-rich glycoprotein	Oryctolagus cuniculus	12-15
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
2824461-0	1987	Differential reactivities of lysines in calmodulin complexed to phosphatase.	Lysine	29-36	calmodulin 1	Homo sapiens	40-50
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
2824461-1	1987	Calmodulin and calmodulin complexed with calcineurin phosphatase were trace labeled with [3H]acetic anhydride and the incorporation of [3H]acetate into each epsilon-amino lysine of calmodulin was measured.	Lysine	171-177	calmodulin 1	Homo sapiens	0-10
2824461-4	1987	When calmodulin was complexed with the phosphatase, Lys-21, Lys-77, and Lys-148 were most protected, implying that these residues are at or near the interaction sites or are conformationally perturbed by the interaction.	Lysine	52-55	calmodulin 1	Homo sapiens	5-15
2824461-1	1987	Calmodulin and calmodulin complexed with calcineurin phosphatase were trace labeled with [3H]acetic anhydride and the incorporation of [3H]acetate into each epsilon-amino lysine of calmodulin was measured.	Lysine	171-177	calmodulin 1	Homo sapiens	15-25
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	40-47	calmodulin 1	Homo sapiens	29-39
2824461-4	1987	When calmodulin was complexed with the phosphatase, Lys-21, Lys-77, and Lys-148 were most protected, implying that these residues are at or near the interaction sites or are conformationally perturbed by the interaction.	Lysine	60-63	calmodulin 1	Homo sapiens	5-15
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	133-136	calmodulin 1	Homo sapiens	29-39
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
2824461-4	1987	When calmodulin was complexed with the phosphatase, Lys-21, Lys-77, and Lys-148 were most protected, implying that these residues are at or near the interaction sites or are conformationally perturbed by the interaction.	Lysine	60-63	calmodulin 1	Homo sapiens	5-15
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Lysine	153-156	calmodulin 1	Homo sapiens	29-39
2824461-8	1987	261, 12226-12232) reveals that calmodulin may interact with each of the two enzymes similarly at or near Lys-21, Lys-75, and Lys-148; one difference with phosphatase is that complex formation also involved Lys-77.	Lysine	105-108	calmodulin 1	Homo sapiens	31-41
2824461-8	1987	261, 12226-12232) reveals that calmodulin may interact with each of the two enzymes similarly at or near Lys-21, Lys-75, and Lys-148; one difference with phosphatase is that complex formation also involved Lys-77.	Lysine	113-116	calmodulin 1	Homo sapiens	31-41
2824461-8	1987	261, 12226-12232) reveals that calmodulin may interact with each of the two enzymes similarly at or near Lys-21, Lys-75, and Lys-148; one difference with phosphatase is that complex formation also involved Lys-77.	Lysine	113-116	calmodulin 1	Homo sapiens	31-41
2824461-8	1987	261, 12226-12232) reveals that calmodulin may interact with each of the two enzymes similarly at or near Lys-21, Lys-75, and Lys-148; one difference with phosphatase is that complex formation also involved Lys-77.	Lysine	113-116	calmodulin 1	Homo sapiens	31-41
3453123-7	1987	The derived sequence contains the sequence Asn-Pro-His-Lys, which is identical to sequence at the pyridoxal phosphate-binding site of porcine DOPA decarboxylase (Bossa et al., 1977).	Lysine	55-58	dopa decarboxylase	Homo sapiens	142-160
2822254-3	1987	We show that in Act88FM342, a flightless Drosophila mutant wherein the Act88F actin gene specifies a glu93----lys replacement, isoelectric points of both actin III and arthrin are shifted, revealing that both are encoded by the same gene.	Lysine	110-113	Actin 88F	Drosophila melanogaster	16-22
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Lysine	110-113	angiotensinogen	Canis lupus familiaris	48-53
3124865-3	1987	For determination of the degree of modification of each lysine residue, selected peptides were subjected to sequence analysis combined with quantitative estimation of the containing PTH-Lys and PTH-epsilon-DHP-Lys.	Lysine	186-189	parathyroid hormone	Homo sapiens	182-185
2830253-4	1987	The sequence of Ch1 has three substitutions from that of turkey muscle acylphosphatase; these are Ser from Ala at position 9, Ser from Arg at 47, and Lys from Asn at 83.	Lysine	150-153	SUN domain containing ossification factor	Gallus gallus	16-19
2825008-4	1987	The lysyl-tRNA synthetase, assayed both as ATP = PPi exchange reaction and lysyl-tRNA synthesis, shows a lower affinity for thialysine and selenalysine than for lysine in both strains; in the mutant, however, the difference is even greater.	Lysine	128-134	lysine--tRNA ligase	Cricetulus griseus	4-25
2825008-5	1987	Thus the thialysine resistance of the mutant is mainly due to the properties of its lysyl-tRNA synthetase, which shows a greater difference of the affinities for lysine and thialysine with respect to the parental strain.	Lysine	13-19	lysine--tRNA ligase	Cricetulus griseus	84-105
3427134-3	1987	It was found that the interaction of Lys-plasminogen with fibrinogen- and fibrin-Sepharose is provided for by the lysine-binding sites of the proenzyme molecule.	Lysine	114-120	fibrinogen beta chain	Homo sapiens	58-68
3427134-4	1987	After partial hydrolysis of fibrinogen by plasmin, the amount of adsorbed plasminogen increases and the type of binding changes; part of the proenzyme molecules bind in the presence of 0.003 M 6-aminohexanoic acid, i.e., when lysine-binding sites appear to be blocked.	Lysine	226-232	fibrinogen beta chain	Homo sapiens	28-38
3427134-8	1987	These sites are complementary for both lysine-and arginine-binding sites of the plasminogen molecule and are localized in the peripheral domains of the fibrinogen molecule.	Lysine	39-45	fibrinogen beta chain	Homo sapiens	152-162
3632667-3	1987	Anionic proteins such as bovine serum albumin also promoted PKC activity toward certain substrates that were characterized by either high arginine or high lysine content.	Lysine	155-161	proline rich transmembrane protein 2	Homo sapiens	60-63
3111475-5	1987	Lys polymers prevented MLD from inhibiting PLA2, whereas monomeric Lys did not.	Lysine	0-3	phospholipase A2 group IB	Homo sapiens	43-47
3311151-10	1987	By use of the known sequence of the human fibrinogen gamma-chain, the sequencing data could be resolved into a dipeptide cross-linked between lysine-406 and either glutamine-398 or -399 (residues 6 and 13 or 14 from the carboxy-terminal end of the gamma-chain) with the loss of residues 401-404 that occur between the cross-link sites of both antiparallel cross-linked gamma-chains.	Lysine	142-148	fibrinogen gamma chain	Homo sapiens	42-64
3112154-1	1987	The active site arginine-143 of human Cu,Zn superoxide dismutase has been replaced by lysine or by isoleucine.	Lysine	86-92	superoxide dismutase 1	Homo sapiens	38-64
3106345-0	1987	Fibrinogen lysine residue A alpha 157 plays a crucial role in the fibrin-induced acceleration of plasminogen activation, catalyzed by tissue-type plasminogen activator.	Lysine	11-17	fibrinogen beta chain	Homo sapiens	0-10
3568326-1	1987	Thrombin cleaves fibrinopeptides from fibrinogen, converting it to fibrin monomer, and activates factor XIII, which catalyzes the formation of intermolecular epsilon-(gamma-glutamyl)-lysine bonds to stabilize the fibrin polymer.	Lysine	183-189	coagulation factor II, thrombin	Homo sapiens	0-8
3034878-3	1987	Close examination of the primary structure of human C-reactive protein revealed three regions evenly distributed throughout the protein each of which contain peptide sequences closely resembling the amino acid sequence of the immunomodulator peptide tuftsin, Thr-Lys-Pro-Arg.	Lysine	263-266	C-reactive protein	Homo sapiens	52-70
3106345-0	1987	Fibrinogen lysine residue A alpha 157 plays a crucial role in the fibrin-induced acceleration of plasminogen activation, catalyzed by tissue-type plasminogen activator.	Lysine	11-17	plasminogen activator, tissue type	Homo sapiens	134-167
3106345-3	1987	We found that the peptides with sequences identical with A alpha 148-161 and A alpha 149-161 of human fibrinogen accelerate the plasminogen activation by t-PA, whereas the corresponding peptides in which lysine residues A alpha 157 had been replaced by valine or arginine had no accelerating capacity.	Lysine	204-210	fibrinogen beta chain	Homo sapiens	102-112
3106345-5	1987	These findings show that lysine residue A alpha 157 is crucial for the accelerating action of fibrin on the t-PA-catalyzed plasminogen activation.	Lysine	25-31	plasminogen activator, tissue type	Homo sapiens	108-112
3108339-0	1987	Plasma amino acids and milk protein production by cows fed rumen-protected methionine and lysine.	Lysine	90-96	casein beta	Bos taurus	23-35
3472221-2	1987	Nucleotide sequence analysis has revealed the primary structure of a 170-amino acid precursor protein that encodes both neurotensin and the neurotensin-like peptide neuromedin N. The peptide-coding domains are located in tandem near the carboxyl terminus of the precursor and are bounded and separated by the paired, basic amino acid residues Lys-Arg.	Lysine	343-346	neurotensin	Canis lupus familiaris	120-131
3472221-2	1987	Nucleotide sequence analysis has revealed the primary structure of a 170-amino acid precursor protein that encodes both neurotensin and the neurotensin-like peptide neuromedin N. The peptide-coding domains are located in tandem near the carboxyl terminus of the precursor and are bounded and separated by the paired, basic amino acid residues Lys-Arg.	Lysine	343-346	neurotensin	Canis lupus familiaris	140-151
3106082-1	1987	Insulin was found to increase protein kinase C activity in BC3H-1 myocytes as determined by in vitro phosphorylation of both a lysine-rich histone fraction (histone III-S) and vinculin.	Lysine	127-133	insulin	Homo sapiens	0-7
3108339-10	1987	Rumen-protected methionine and lysine increased production of milk protein.	Lysine	31-37	casein beta	Bos taurus	62-74
3112244-1	1987	Two lower-molecular-weight derivatives of recombinant human interferon-gamma (rIFN-gamma) were purified concurrently from a lysozyme-EDTA extract of Escherichia coli cells by immunoaffinity chromatography using a monoclonal antibody (MAb) against a synthetic carboxy-terminal peptide (Lys-131-Gln-146).	Lysine	285-288	interferon gamma	Homo sapiens	60-76
2436353-3	1987	It has been proposed that aldehyde metabolites of TMP form Schiff base adducts with the lysine groups of alpha 2u-globulin and thereby inhibit renal lysosomal processing of the protein.	Lysine	88-94	alpha2u globulin	Rattus norvegicus	105-122
3100536-3	1987	We have now established that the fragment extends to residue Lys-728 and demonstrate here that a high affinity heparin-binding domain of vWF also lies within this region and in close proximity to that for GPIb.	Lysine	61-64	von Willebrand factor	Homo sapiens	137-140
3105580-2	1987	The method shows that acetylation of lysines affects calmodulin so as to interfere with its ability to interact with calcineurin.	Lysine	37-44	calmodulin 1	Homo sapiens	53-63
3105580-3	1987	Monoacetylation of any lysine of calmodulin reduces its affinity for calcineurin by 5-10-fold.	Lysine	23-29	calmodulin 1	Homo sapiens	33-43
3105580-5	1987	The lack of selectivity of calcineurin against any particular modified lysine indicates that the loss of affinity reflects changes induced by the removal of the charged groups and suggests an important role for electrostatic interactions in the cooperative structural transitions which calmodulin undergoes upon binding its target proteins or calcium.	Lysine	71-77	calmodulin 1	Homo sapiens	286-296
3105580-6	1987	In the presence of calcineurin, a large and specific decrease in the rate of acetylation of Lys-75 and -148 of calmodulin is observed.	Lysine	92-95	calmodulin 1	Homo sapiens	111-121
3102467-0	1987	Calmodulin is labeled at lysine 148 by a chemically reactive phenothiazine.	Lysine	25-31	calmodulin 1	Homo sapiens	0-10
2436653-9	1987	A four-residue basic sequence (Arg-Ser-Lys-Arg) was identified upstream of the amino-terminal Asn of C5a, thereby specifying a beta alpha-chain orientation for the promolecule form of murine C5.	Lysine	39-42	hemolytic complement	Mus musculus	101-104
3102491-0	1987	Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.	Lysine	72-78	apolipoprotein B	Homo sapiens	91-107
3102491-3	1987	Several chemical modifications of LDL also lead to recognition by this receptor; all of these involve derivatization of lysine residues of apolipoprotein B by adducts that neutralize the positively charged epsilon-amino group.	Lysine	120-126	apolipoprotein B	Homo sapiens	139-155
3103628-7	1987	Cytosolic proteins as well as bovine serum albumin and poly-L-lysine (Mr = 57,000) protected purified bee venom phospholipase A2 from inactivation by manoalide.	Lysine	55-68	phospholipase A2 group IB	Homo sapiens	112-128
3103628-10	1987	These data suggest that lysine is capable of reacting with manoalide, but only when it is present in macromolecules is it capable of protecting phospholipase A2 from inactivation by manoalide.	Lysine	24-30	phospholipase A2 group IB	Homo sapiens	144-160
3036070-1	1987	The amino acid sequence of human C1r A chain was determined, from sequence analysis performed on fragments obtained from C1r autolytic cleavage, cleavage of methionyl bonds, tryptic cleavages at arginine and lysine residues, and cleavages by staphylococcal proteinase.	Lysine	208-214	complement C1r	Homo sapiens	33-36
3108419-1	1987	Antibodies to a synthetic carboxy-terminal peptide (Cys-Ser-Leu-Arg-Lys-Arg-Lys-Arg-Ser-Arg-Abu) (gamma-C-TP) of mouse interferon-gamma (MuIFN-gamma) were produced in rabbits.	Lysine	68-71	interferon gamma	Mus musculus	119-135
3101598-6	1987	This region also contains lysine residues participating in the cross-linking of fibrin and, possibly, a site involved in the binding of fibrinogen to receptors on platelets.	Lysine	26-32	fibrinogen beta chain	Homo sapiens	136-146
3101593-0	1987	Calcium effects on calmodulin lysine reactivities.	Lysine	30-36	calmodulin 1	Homo sapiens	19-29
3474930-3	1987	Although the tubulin molecule has multiple lysine resides available to react with acetaldehyde, certain key lysine residues on the alpha-chain appear to be selective targets for adduct formation.	Lysine	108-114	Fc gamma receptor and transporter	Homo sapiens	131-142
3101593-1	1987	The differential reactivities of individual lysines on porcine testicular calmodulin were determined by trace labeling with high specific activity [3H]acetic anhydride as a function of the molar ratio of Ca2+ to calmodulin.	Lysine	44-51	calmodulin 1	Homo sapiens	74-84
2485059-5	1987	Several newer ACE inhibitors have increased potency and/or improved pharmacokinetic properties due to modifications such as substitution of the proline ring or replacement of the methyl side chain analogous to Ala by an aminobutyl residue analogous to Lys.	Lysine	252-255	angiotensin I converting enzyme	Homo sapiens	14-17
3101593-5	1987	One class, comprising lysines 94 and 148 from the two carboxy terminal Ca2+-binding domains 3 and 4, respectively, exhibited about 90% of their reactivity change when the Ca2+:calmodulin molar ratio was 2:1, and these residues were perturbed very little upon further addition of Ca2+.	Lysine	22-29	calmodulin 1	Homo sapiens	176-186
3101593-6	1987	The other class, encompassing lysines 13, 21, and 30 from the amino terminal domain 1 and Lys 75 from the extended helix connecting the two globular lobes of calmodulin, underwent most of their overall reactivity change (55-70%) between 2 and 5 equivalents of Ca2+ per mol of calmodulin.	Lysine	30-37	calmodulin 1	Homo sapiens	158-168
3101593-6	1987	The other class, encompassing lysines 13, 21, and 30 from the amino terminal domain 1 and Lys 75 from the extended helix connecting the two globular lobes of calmodulin, underwent most of their overall reactivity change (55-70%) between 2 and 5 equivalents of Ca2+ per mol of calmodulin.	Lysine	90-93	calmodulin 1	Homo sapiens	158-168
3101593-11	1987	In the course of this work, it was found that Lys 94 in apocalmodulin is specifically perturbed by the addition of EGTA, suggesting that the chelating agent may interact with calmodulin at or near the third Ca2+-binding domain.	Lysine	46-49	calmodulin 1	Homo sapiens	59-69
2822504-2	1987	Several calmodulin derivatives prepared by chemical modification of lysine residues were tested using bovine heart cyclic nucleotide phosphodiesterase and wheat germ calmodulin-dependent protein kinase.	Lysine	68-74	calmodulin	Bos taurus	8-18
3790160-1	1986	Calmodulin can be specifically acylated with a fluorene-containing hydrophobic spin-labeling reagent at just Lys 75 or at Lys 75 and Lys 148.	Lysine	109-112	calmodulin 1	Homo sapiens	0-10
3021732-4	1986	Human recombinant t-PA deletion-mutant proteins were prepared and their ability to bind to lysine-Sepharose was investigated.	Lysine	91-97	plasminogen activator, tissue type	Homo sapiens	18-22
3099422-1	1986	Poly-L-lysine and certain mixed polymers of L-lysine and other amino acids modify the activity of one- and two-chain tissue-type plasminogen activator (t-PA) towards its substrates.	Lysine	0-13	plasminogen activator, tissue type	Homo sapiens	117-150
3099422-1	1986	Poly-L-lysine and certain mixed polymers of L-lysine and other amino acids modify the activity of one- and two-chain tissue-type plasminogen activator (t-PA) towards its substrates.	Lysine	0-13	plasminogen activator, tissue type	Homo sapiens	152-156
3099422-1	1986	Poly-L-lysine and certain mixed polymers of L-lysine and other amino acids modify the activity of one- and two-chain tissue-type plasminogen activator (t-PA) towards its substrates.	Lysine	5-13	plasminogen activator, tissue type	Homo sapiens	117-150
3099422-1	1986	Poly-L-lysine and certain mixed polymers of L-lysine and other amino acids modify the activity of one- and two-chain tissue-type plasminogen activator (t-PA) towards its substrates.	Lysine	5-13	plasminogen activator, tissue type	Homo sapiens	152-156
3096995-7	1986	Modifications of the lysine residues of apoB (e.g. acetylation) reduced both the capacity of LDL to inhibit urate crystal-induced CL and to bind to urate crystals.	Lysine	21-27	apolipoprotein B	Homo sapiens	40-44
3096995-8	1986	The effects of apoB lysine residue modification were reversible, proportional to the extent of modification, and were not attributable to alteration of the net charge of apoB.	Lysine	20-26	apolipoprotein B	Homo sapiens	15-19
3768376-6	1986	In addition, the fluorescence of an NBD group fixed on lysine 60, which is very close to the aromatic region in the pig colipase, is also altered in the presence of micelles.	Lysine	55-61	colipase	Sus scrofa	120-128
3827867-1	1986	Three Arg/Lys-Xaa bonds in the B-chain of human alpha-thrombin were found to be the major autolytic sites.	Lysine	10-13	coagulation factor II, thrombin	Homo sapiens	54-62
3827867-8	1986	There exists a new form of autolysed thrombin, designated as beta"-thrombin (with cleavage at Lys-Gly only), which also serves as the intermediate in the conversion of alpha-thrombin into gamma-thrombin.	Lysine	94-97	coagulation factor II, thrombin	Homo sapiens	37-45
3827867-8	1986	There exists a new form of autolysed thrombin, designated as beta"-thrombin (with cleavage at Lys-Gly only), which also serves as the intermediate in the conversion of alpha-thrombin into gamma-thrombin.	Lysine	94-97	coagulation factor II, thrombin	Homo sapiens	67-75
3827867-8	1986	There exists a new form of autolysed thrombin, designated as beta"-thrombin (with cleavage at Lys-Gly only), which also serves as the intermediate in the conversion of alpha-thrombin into gamma-thrombin.	Lysine	94-97	coagulation factor II, thrombin	Homo sapiens	67-75
3827867-8	1986	There exists a new form of autolysed thrombin, designated as beta"-thrombin (with cleavage at Lys-Gly only), which also serves as the intermediate in the conversion of alpha-thrombin into gamma-thrombin.	Lysine	94-97	coagulation factor II, thrombin	Homo sapiens	67-75
2437225-2	1986	In contrast, LO-22 bound strongly to IFN-alpha 2 (IFN-alpha 2b) and IFN-alpha 2C (IFN-alpha 2c) which differ by one or two amino acids, respectively, from IFN-alpha A; the latter has lysine at position 23 whereas the other closely related IFNs have arginine.	Lysine	183-189	interferon alpha 1	Homo sapiens	37-46
2877981-8	1986	The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI.	Lysine	30-36	fibrinogen beta chain	Homo sapiens	81-91
2877981-8	1986	The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI.	Lysine	70-73	fibrinogen beta chain	Homo sapiens	81-91
2877981-8	1986	The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI.	Lysine	113-119	fibrinogen beta chain	Homo sapiens	81-91
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Lysine	143-146	arginine vasopressin	Homo sapiens	50-61
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Lysine	143-146	arginine vasopressin	Homo sapiens	181-192
2877456-4	1986	A second specific cleavage after Lys-513 by thrombin inactivates factor XIIIa and produces an amino-terminal 56-kDa fragment and a 24-kDa fragment.	Lysine	33-36	coagulation factor II, thrombin	Homo sapiens	44-52
2877456-4	1986	A second specific cleavage after Lys-513 by thrombin inactivates factor XIIIa and produces an amino-terminal 56-kDa fragment and a 24-kDa fragment.	Lysine	33-36	coagulation factor XIII A chain	Homo sapiens	65-77
3756185-6	1986	Inhibition studies with pT and pTp showed that a cationic binding group (P0) for the 5"-phosphate of the pyrimidine nucleotides bound at the primary B1 site is present in turtle ribonuclease, although lysine at position 66 in bovine ribonuclease is absent in turtle ribonuclease.	Lysine	201-207	lithostathine	Bos taurus	24-26
2875689-2	1986	In order to avoid formation of protein crosslinks, rhodopsin was first reductively methylated to modify its lysines.	Lysine	108-115	rhodopsin	Homo sapiens	51-60
3091599-0	1986	Effects of the binding of myosin light chain kinase on the reactivities of calmodulin lysines.	Lysine	86-93	calmodulin 1	Homo sapiens	75-85
3091599-11	1986	In conjunction with previously published data, these results are interpreted as suggesting that the major perturbation in lysine 75 is a direct effect of MLC kinase contact with CaM and that a region in the central helix containing this residue, but not lysine 77, represents or is near the CaM-binding site for MLC kinase.	Lysine	122-128	calmodulin 1	Homo sapiens	178-181
3091599-12	1986	The smaller changes in reactivities at lysines 21 and 148 may reflect a conformational change that occurs in CaM as a result of binding to MLC kinase.	Lysine	39-46	calmodulin 1	Homo sapiens	109-112
3015218-2	1986	Non-enzymatic glucosylation of lysine residues of apolipoprotein B, the major protein of LDL, blocks receptor-mediated uptake of LDL by fibroblasts and endothelial cells.	Lysine	31-37	apolipoprotein B	Homo sapiens	50-66
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Lysine	24-27	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Lysine	32-35	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Lysine	32-35	coagulation factor II, thrombin	Homo sapiens	115-123
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Lysine	167-173	thrombospondin 1	Homo sapiens	0-14
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Lysine	167-173	thrombospondin 1	Homo sapiens	16-19
3522581-3	1986	H-protein consists of 125 amino acids and a lipoic acid moiety linked to lysine 59.	Lysine	73-79	myosin binding protein H like	Gallus gallus	0-9
2872929-10	1986	Altogether, these studies indicate that factor XIIIa can readily form covalent bonds between glutamine in vWF and lysine in fibrin alpha chains.	Lysine	114-120	coagulation factor XIII A chain	Homo sapiens	40-52
2432871-3	1986	The deposition of elastin requires the covalent cross-linking of tropoelastin by means of lysine-derived cross-links.	Lysine	90-96	elastin	Gallus gallus	18-25
2432871-3	1986	The deposition of elastin requires the covalent cross-linking of tropoelastin by means of lysine-derived cross-links.	Lysine	90-96	elastin	Gallus gallus	65-77
3730052-0	1986	The biochemistry of epsilon-amino groups of lysine residues from apolipoprotein B of human low density lipoprotein.	Lysine	44-50	apolipoprotein B	Homo sapiens	65-81
3730052-2	1986	Amino acid analyses of detergent-solubilized apolipoprotein B, following cyanoethylation with acrylonitrile, revealed that 10% of the lysine in apolipoprotein B were unreactive.	Lysine	134-140	apolipoprotein B	Homo sapiens	144-160
3711098-5	1986	The amino acid composition of gpL115 has several atypical features including low lysine content, high proline content, and very high content of hydroxyamino acids (12.5 residues of serine and 12.5 residues of threonine/100 amino acids).	Lysine	81-87	sialophorin	Homo sapiens	30-36
3730052-4	1986	Since apolipoprotein B has a high molecular weight a study was undertaken to determine whether lysine residues were crosslinked to glutamic acid via epsilon-(gamma-glutamyl)lysine as demonstrated for fibrin.	Lysine	95-101	apolipoprotein B	Homo sapiens	6-22
3730052-7	1986	In contrast to earlier reports for serum LDL the data showed that less than 0.01 moles of lysine/mole of LDL apolipoprotein B were present as epsilon-(gamma-glutamyl)lysine in plasma LDL.	Lysine	90-96	apolipoprotein B	Homo sapiens	109-125
3527696-2	1986	Sequential Edman degradation and carboxypeptidase digestion unambiguously establish that histones H2A, H2B, H3 and H4 are selectively cleaved at the carboxyl side of Arg 11, Lys 20, Arg 26 and Arg 19 respectively and that the C-terminal sequences remain unaffected.	Lysine	174-177	histone cluster 1, H2bg	Rattus norvegicus	103-117
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3088041-5	1986	1, of tissue-type plasminogen activator that contained a growth factor and two kringle segments retained its lysine binding activity.	Lysine	109-115	plasminogen activator, tissue type	Homo sapiens	6-39
3093470-2	1986	The derivatives of cis-4,5-dehydrolysine were hydrolyzed much more slowly than those of lysine, owing largely to the small kcat values for the former.	Lysine	34-40	suppressor of cytokine signaling 6	Homo sapiens	19-24
3711896-6	1986	Converted calmodulin was isolated by fast protein liquid chromatography and shown to be des(Lys)calmodulin, lacking the carboxy terminal lysine residue of calmodulin.	Lysine	137-143	calmodulin 1	Homo sapiens	10-20
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
2482748-0	1986	One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.	Lysine	74-77	tachykinin precursor 1	Homo sapiens	45-56
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-3	1986	Kinins were found in the following proportions: 53 +/- 3% bradykinin, 23 +/- 4% Lys-bradykinin, and 13 +/- 7% des-Arg1-bradykinin in dog urine; 67 +/- 6% bradykinin, 6 +/- 3% Lys-bradykinin, and 10 +/- 3% des-Arg1-bradykinin in rat urine; and 12 +/- 4% bradykinin, 30 +/- 3% Lys-bradykinin, 2 +/- 1% des-Arg1-bradykinin, and 41 +/- 3% unknown kinin in human urine.	Lysine	80-83	kininogen 1	Canis lupus familiaris	84-94
3635531-5	1986	Amino acid sequencing revealed a structure similar to Lys-bradykinin except that proline in position 4 was replaced by alanine ([Ala3]Lys-bradykinin).	Lysine	54-57	kininogen 1	Homo sapiens	58-68
3754463-3	1986	A fragment of MLCK containing the phosphorylation site was shown to have the amino acid sequence Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu- Ser-Ser.	Lysine	109-112	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	14-18
2424500-1	1986	The peptide portion of the lipopeptide isolated from bovine myelin basic protein contained glycine, lysine, and serine in a 2:1:1 molar ratio as determined by amino acid analysis.	Lysine	100-106	myelin basic protein	Bos taurus	60-80
3723016-5	1986	64: 380-383), represents a mutation in apoA-I in which a single amino acid substitution of lysine for glutamic acid has taken place at residue 136.	Lysine	91-97	apolipoprotein A1	Homo sapiens	39-45
3012559-4	1986	The question of whether the deprotonation of the protonated Schiff base is obligate in the formation of activated rhodopsin was addressed by monomethylating the active-site lysine of permethylated rhodopsin and determining whether this pigment can activate the G protein upon photolysis.	Lysine	173-179	rhodopsin	Homo sapiens	114-123
3012559-4	1986	The question of whether the deprotonation of the protonated Schiff base is obligate in the formation of activated rhodopsin was addressed by monomethylating the active-site lysine of permethylated rhodopsin and determining whether this pigment can activate the G protein upon photolysis.	Lysine	173-179	rhodopsin	Homo sapiens	197-206
3711069-6	1986	Upon binding of manganese ions, calmodulin underwent a change of susceptibility to trypsin, resulting in cleavage at Lys 77, as observed for calcium-bound calmodulin.	Lysine	117-120	calmodulin	Bos taurus	32-42
3711069-6	1986	Upon binding of manganese ions, calmodulin underwent a change of susceptibility to trypsin, resulting in cleavage at Lys 77, as observed for calcium-bound calmodulin.	Lysine	117-120	calmodulin	Bos taurus	155-165
3754463-3	1986	A fragment of MLCK containing the phosphorylation site was shown to have the amino acid sequence Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu- Ser-Ser.	Lysine	121-124	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	14-18
3947350-3	1986	Synthetic peptides of apoE corresponding to residues 129-169, 139-169, and 144-169, but not 148-169, bound [125I] heparin suggesting that residues 144-147 (Leu-Arg-Lys-Arg) in E22 are important for binding.	Lysine	164-167	apolipoprotein E	Homo sapiens	22-26
3008720-0	1986	Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils.	Lysine	13-19	myeloperoxidase	Homo sapiens	50-65
3008720-1	1986	Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release.	Lysine	17-23	myeloperoxidase	Homo sapiens	59-74
3008720-1	1986	Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release.	Lysine	174-180	myeloperoxidase	Homo sapiens	59-74
2430174-2	1986	The ATP analog p-fluorosulfonyl 5"-benzoyl adenosine inactivates both p60src and the catalytic subunit of the cyclic AMP-dependent protein kinase by modification of this lysine.	Lysine	170-176	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-76
3081373-0	1986	Plasminogen-binding site of the thermostable region of fibrinogen fragment D. Affinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinogen TSD fragment has shown that the latter contains a plasminogen-binding site which is complementary to the lysine-binding site(s) of plasminogen molecule 1-3 kringle structures.	Lysine	278-284	fibrinogen beta chain	Homo sapiens	55-65
3086526-3	1986	After 10 days of reaction with alpha-dicarbonyls, the amino acid composition of lysozyme was markedly affected; i.e., 30-70% of lysine, 40-50% of tryptophan and 90% of arginine were lost respectively.	Lysine	128-134	lysozyme	Homo sapiens	80-88
2419146-6	1986	The contractile potency of NKA and NKB remained nearly complete after removal of N-terminal tripeptide portions, i.e., His-Lys-Thr and Asp-Met-His from the native peptides, respectively.	Lysine	123-126	tachykinin-3	Cavia porcellus	35-38
3510062-4	1986	Amino acid analysis of the apolipoprotein B revealed that 4-hydroxynonenal attacks mainly the lysine and tyrosine residues and to a lesser extent also serine, histidine and cysteine.	Lysine	94-100	apolipoprotein B	Homo sapiens	27-43
3006793-5	1986	A variation in the number or/and the arrangement of the charged groups at the "active sites" of the molecules induced by both changing the medium pH and chemical modification of some of these groups lowers markedly the probability of electron transfer in the system (e.g. His GH1 and His A10 in Mb) or blocks it entirely (acylation of Lys 72 (73) or Tyr 74 in Cyt C).	Lysine	335-338	growth hormone 1	Homo sapiens	276-279
3714530-6	1986	Cleavage at a single lysine residue has not been reported for posttranslational processing of beta-endorphin in mammals and could represent a modification seen only in lower vertebrates.	Lysine	21-27	proopiomelanocortin	Homo sapiens	94-108
3011536-1	1986	Its N epsilon-acetylated lysine derivative.	Lysine	25-31	intersectin 1	Homo sapiens	0-5
3029548-2	1986	Both molecules mediated fusion of phosphatidylserine (PS):PC 1:1 vesicles as measured by energy transfer changes between fluorescent lipid probes in a concentration- and pH-dependent manner, although cytochrome c was less potent and interacted over a more limited pH range than the apocytochrome c. Maximal fusion occurred at pH 3, far below the pKa of the 19 lysine groups contained in the protein (pI = 10.5).	Lysine	360-366	cytochrome c, somatic	Homo sapiens	200-212
2877922-6	1986	When compared with the human Epo, monkey Epo has an additional 3-aa residue at the N terminus of the mature protein and a deletion of an internal lysine residue.	Lysine	146-152	erythropoietin	Homo sapiens	41-44
3743871-2	1986	Reassociation experiments with chemically modified lysozymes indicate that positively charged amino acid residues of lysozyme (the epsilon-amino group of lysine and the guanidino group of arginine) are involved in the interaction with other proteins of the vitelline membrane.	Lysine	154-160	lysozyme	Homo sapiens	51-59
2438487-2	1986	ACE also has important arginine and tyrosine residues that are involved in substrate binding and a lysine that binds chloride.	Lysine	99-105	angiotensin I converting enzyme	Homo sapiens	0-3
3933567-2	1985	Synthesis of apolipoprotein B in the intestine and liver in suckling rats whose duodena had been infused with [3H]lysine was estimated by measuring the radioactivity in the mesenteric lymph and blood serum.	Lysine	114-120	apolipoprotein B	Rattus norvegicus	13-29
3937276-1	1985	Two variants (I and II) of tissue-type plasminogen activator (t-PA) from human melanoma cells were separated by Lysine Sepharose chromatography.	Lysine	112-118	plasminogen activator, tissue type	Homo sapiens	27-60
2998483-0	1985	Lysine binding to activated human platelets and its similarity to fibrinogen binding.	Lysine	0-6	fibrinogen beta chain	Homo sapiens	66-76
3933567-4	1985	In the serum d less than 1.21 g/ml fraction obtained from the lymph-diverted rats, apolipoprotein B of high molecular weight was only labeled with [3H]lysine in suckling rats, whereas both forms of apolipoprotein B were labeled in the adult rats.	Lysine	151-157	apolipoprotein B	Rattus norvegicus	83-99
3004508-0	1985	[Synthesis and biological activity of a lysine-containing cyclic analog of [Leu5]enkephalin].	Lysine	40-46	tripartite motif-containing 13	Mus musculus	76-80
4074360-1	1985	A radioactive photoaffinity probe for the insulin receptor was prepared by derivatizing insulin at its B29 lysine with a novel crosslinking reagent having a cleavable azo linkage.	Lysine	107-113	insulin	Homo sapiens	42-49
2932437-5	1985	Lysines 75 and 94 were found to be the most reactive amino groups in Ca2+-saturated calmodulin.	Lysine	0-7	calmodulin 1	Homo sapiens	84-94
2932437-6	1985	In the presence of Ca2+ and under conditions where beta-endorphin and calmodulin were present at a molar ratio of 2.5:1, the amino groups of lysines 75 and 148 were significantly reduced in reactivity compared to calmodulin alone.	Lysine	141-148	proopiomelanocortin	Homo sapiens	51-65
2932437-6	1985	In the presence of Ca2+ and under conditions where beta-endorphin and calmodulin were present at a molar ratio of 2.5:1, the amino groups of lysines 75 and 148 were significantly reduced in reactivity compared to calmodulin alone.	Lysine	141-148	calmodulin 1	Homo sapiens	70-80
2932437-8	1985	With trifluoperazine, at a molar ratio to calmodulin of 2.5:1, significant perturbations of lysines 75 and 148, as well as Lys 77, were also found.	Lysine	92-99	calmodulin 1	Homo sapiens	42-52
2932437-8	1985	With trifluoperazine, at a molar ratio to calmodulin of 2.5:1, significant perturbations of lysines 75 and 148, as well as Lys 77, were also found.	Lysine	123-126	calmodulin 1	Homo sapiens	42-52
2932437-10	1985	Lastly, an intriguing difference in Ca2+-mediated reactivities between lysines 75 and 77 of calmodulin is demonstrated.	Lysine	71-78	calmodulin 1	Homo sapiens	92-102
2932437-13	1985	Yet, Lys 75 increases in reactivity some 25-fold, compared to only a 2-fold change for Lys 77, in going from EGTA-treated to Ca2+-saturated calmodulin.	Lysine	5-8	calmodulin 1	Homo sapiens	140-150
2932437-13	1985	Yet, Lys 75 increases in reactivity some 25-fold, compared to only a 2-fold change for Lys 77, in going from EGTA-treated to Ca2+-saturated calmodulin.	Lysine	87-90	calmodulin 1	Homo sapiens	140-150
2932437-14	1985	Thus, the microenvironment of Lys 75 is markedly altered upon Ca2+ binding, and this linker region between the two globular lobes of the protein appears to be quite important in the interaction of calmodulin with inhibitory molecules and perhaps activatable enzymes.	Lysine	30-33	calmodulin 1	Homo sapiens	197-207
2932437-0	1985	Differential trace labeling of calmodulin: investigation of binding sites and conformational states by individual lysine reactivities.	Lysine	114-120	calmodulin 1	Homo sapiens	31-41
2996932-0	1985	Involvement of lysine residues in the binding of ovine prolactin and human growth hormone to lactogenic receptors.	Lysine	15-21	prolactin	Homo sapiens	55-64
2411731-7	1985	Both the alpha 2(I) and alpha 2(V) telopeptides are devoid of a lysine, which in alpha 1 chains forms an interchain cross-link with residue 87 of the collagenous region.	Lysine	64-70	collagen type V alpha 2 chain	Homo sapiens	24-34
3001041-4	1985	There were 11 lysines and 6 arginines in Ch1, whereas there were 6 lysines and 11 arginines in Ch2.	Lysine	14-21	SUN domain containing ossification factor	Gallus gallus	41-44
3161948-2	1985	Tryptase (5 micrograms/ml) inactivated the thrombin-induced clotting activity of fibrinogen (100 micrograms/ml) with essentially similar t 1/2 values of 4.6 min in the absence of heparin and 5.8 min in the presence of heparin (20 micrograms/ml) that were not appreciably different than with lysine-Sepharose-purified plasmin (5 micrograms/ml).	Lysine	291-297	coagulation factor II, thrombin	Homo sapiens	43-51
2864688-7	1985	The same carboxyl-terminal lysine residue was identified in the mature protein as well as in the cDNA, indicating that all of the proteolytic processing that occurs during the biosynthesis and assembly of von Willebrand factor is associated with the amino-terminal portion of the precursor protein.	Lysine	27-33	von Willebrand factor	Homo sapiens	205-226
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Lysine	85-88	thioredoxin 1	Rattus norvegicus	132-143
16664269-3	1985	The same preparations of calmodulin do not show major differences in phosphodiesterase or myosin light chain kinase activator activity.We report here that a Chlamydomonas calmodulin has four primary structural features similar to Dictyostelium that are not found in other calmodulins characterized to date: an altered carboxy terminus including a novel 11-residue extension for Chlamydomonas calmodulin, unique residues at positions 81 and 118, and an unmethylated lysine at position 115.	Lysine	465-471	calmodulin 1	Homo sapiens	171-181
3929832-5	1985	These results, together with kinetic data at variable complex concentrations or at variable temperatures, indicate that specific lysine residues of apolipoprotein A-I are not involved in the lecithin:cholesterol acyltransferase activation process; instead, charge interactions and structural changes are responsible for the observed decrease in activating capacity.	Lysine	129-135	apolipoprotein A1	Homo sapiens	148-166
2414373-1	1985	Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS).	Lysine	78-91	interferon alpha 1	Homo sapiens	0-10
2414373-1	1985	Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS).	Lysine	78-91	interferon alpha 1	Homo sapiens	12-15
2863141-5	1985	All selected polypeptides have one single major cleavage site and both Arg-Xaa and Lys-Xaa bonds were found to be selectively cleaved by alpha-thrombin.	Lysine	83-86	coagulation factor II, thrombin	Homo sapiens	143-151
2991265-13	1985	His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 (substance K) and bombesin are degraded by striatal but not lung ACE.	Lysine	4-7	angiotensin I converting enzyme	Rattus norvegicus	109-112
4054823-7	1985	Moreover, lysine hydroxylation and copper contents showed an increase in both OA and ANF; these findings suggest that repairing reaction of the pathological lesion by proliferation of undifferentiated tissue remained even in late stage of the disease.	Lysine	10-16	natriuretic peptide A	Homo sapiens	85-88
16664269-3	1985	The same preparations of calmodulin do not show major differences in phosphodiesterase or myosin light chain kinase activator activity.We report here that a Chlamydomonas calmodulin has four primary structural features similar to Dictyostelium that are not found in other calmodulins characterized to date: an altered carboxy terminus including a novel 11-residue extension for Chlamydomonas calmodulin, unique residues at positions 81 and 118, and an unmethylated lysine at position 115.	Lysine	465-471	calmodulin 1	Homo sapiens	171-181
16664269-4	1985	The only amino acid sequence identity unique to Chlamydomonas and Dictyostelium calmodulin is the presence of a lysine at position 115 instead of a trimethyllysine.	Lysine	112-118	calmodulin 1	Homo sapiens	80-90
16664269-5	1985	These studies indicate that the methylation state of lysine 115 may be important in the maximal NAD kinase activator activity of calmodulin and support the concept that calmodulin has multiple functional domains in addition to multiple structural domains.	Lysine	53-59	calmodulin 1	Homo sapiens	129-139
16664269-5	1985	These studies indicate that the methylation state of lysine 115 may be important in the maximal NAD kinase activator activity of calmodulin and support the concept that calmodulin has multiple functional domains in addition to multiple structural domains.	Lysine	53-59	calmodulin 1	Homo sapiens	169-179
2983990-4	1985	Other tyrosine-containing polymers Ala/Glu/Lys/Tyr (6:2:5:1) and Glu/Ala/Tyr (6:3:1) were also phosphorylated by the insulin-stimulated kinase but to a lower extent.	Lysine	43-46	insulin	Homo sapiens	117-124
3997864-10	1985	This suggests that a lysine residue may be important in understanding the substrate specificity of phospholipase A2.	Lysine	21-27	phospholipase A2 group IB	Homo sapiens	99-115
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Lysine	327-333	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
2985592-4	1985	The anomeric carbon region of the spectrum (approximately 90-105 ppm) of glycated cytochrome c was superimposable on that of N alpha-formyl-N epsilon-fructose-lysine, and contained three peaks characteristic of the alpha- and beta-furanose and beta-pyranose anomers of Amadori adducts to peripheral lysine residues on protein (pK alpha approximately 10.5).	Lysine	159-165	cytochrome c, somatic	Homo sapiens	82-94
2985592-4	1985	The anomeric carbon region of the spectrum (approximately 90-105 ppm) of glycated cytochrome c was superimposable on that of N alpha-formyl-N epsilon-fructose-lysine, and contained three peaks characteristic of the alpha- and beta-furanose and beta-pyranose anomers of Amadori adducts to peripheral lysine residues on protein (pK alpha approximately 10.5).	Lysine	299-305	cytochrome c, somatic	Homo sapiens	82-94
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	12-15	cytochrome c, somatic	Homo sapiens	22-34
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	12-15	cytochrome c, somatic	Homo sapiens	94-106
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	12-15	cytochrome c, somatic	Homo sapiens	94-106
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	134-137	cytochrome c, somatic	Homo sapiens	22-34
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	134-137	cytochrome c, somatic	Homo sapiens	94-106
2985578-9	1985	One is from Lys 13 of cytochrome c to an acidic residue in positions 32, 33, 34, 35, or 37 of cytochrome c peroxidase, the other from Lys 86 of cytochrome c to a carboxyl group in the same cluster of acidic residues.	Lysine	134-137	cytochrome c, somatic	Homo sapiens	94-106
2985578-10	1985	The result stresses the importance of a peculiar stretch of acidic residues of cytochrome c peroxidase and of Lys 13 and 86 of cytochrome c.	Lysine	110-113	cytochrome c, somatic	Homo sapiens	127-139
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Lysine	150-153	proopiomelanocortin	Bos taurus	67-87
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Lysine	200-203	proopiomelanocortin	Bos taurus	67-87
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Lysine	200-203	proopiomelanocortin	Bos taurus	217-237
2985583-3	1985	Analyses of the cyanogen bromide fragments of the protein conjugate indicate that lysine 115 on calmodulin is the ubiquitin conjugation site.	Lysine	82-88	calmodulin	Bos taurus	96-106
2985583-6	1985	Since there are eight lysine residues in Dictyostelium calmodulin, the specific conjugation of ubiquitin to lysine 115 may provide a good model system to delineate the structural features required for the conjugation and to follow the degradative steps in the pathway.	Lysine	22-28	calmodulin	Bos taurus	55-65
2985583-6	1985	Since there are eight lysine residues in Dictyostelium calmodulin, the specific conjugation of ubiquitin to lysine 115 may provide a good model system to delineate the structural features required for the conjugation and to follow the degradative steps in the pathway.	Lysine	108-114	calmodulin	Bos taurus	55-65
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Lysine	302-308	HDL3	Homo sapiens	244-248
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Lysine	302-308	HDL3	Homo sapiens	255-259
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Lysine	302-308	apolipoprotein A1	Homo sapiens	354-382
3156054-0	1985	C-terminal lysine residues of fibrinogen fragments essential for binding to plasminogen.	Lysine	11-17	fibrinogen beta chain	Homo sapiens	30-40
3156054-1	1985	Experiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmin-catalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen.	Lysine	171-177	fibrinogen beta chain	Homo sapiens	227-237
3918583-4	1985	Calmodulin inactivated by modification of lysine residues still is able to bind four calcium ions per molecule and shows strong binding to phenyl-Sepharose similar to native calmodulin.	Lysine	42-48	calmodulin 1	Homo sapiens	0-10
3916937-1	1985	Methylated lysine, arginine and histidine residues are found in a number of proteins (for example, histones, non-histone chromosomal proteins, ribosomal proteins, calmodulin, cytochrome C, etc.).	Lysine	11-17	cytochrome c, somatic	Homo sapiens	175-187
3925116-0	1985	Binding of 2-(4"-hydroxyphenylazo) benzoic acid with arginine, lysine, tyrosine and tryptophan modified bovine serum albumin.	Lysine	63-69	albumin	Homo sapiens	111-124
4008463-2	1985	Together with this modification, the use of a synthetic carrier, Polybrene, the minimization of aldehyde contamination in Quadrol buffer, and the introduction of hydrophilic groups into epsilon-N-amino groups of lysine residues, markedly increased the repetitive yield of PTH-amino acids.	Lysine	212-218	parathyroid hormone	Homo sapiens	272-275
2981572-6	1985	18 h after administration to rats in vivo, the hormone species containing des-(Lys-91-Ser-92)-alpha or des-(90-92)-alpha, respectively, were found to have induced a decrease in microsomal cytochrome P-450 content with an effectiveness corresponding to their ability of stimulating the adenylate cyclase in vitro.	Lysine	79-82	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	188-204
2981572-7	1985	However, when assayed 48 h after application, the desensitization of the microsomal cytochrome P-450 system had persisted in case of the hCG species containing a des-(90-92)-alpha chain but not in case of hCG consisting of des-(Lys-91-Ser-92)-alpha and a native beta-subunit.	Lysine	228-231	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	84-100
3967761-1	1985	Albumin Mi/Fg is an Italian genetic variant of human serum albumin arising from a Lys----Glu substitution which has been located in a CNBr fragment (CNBr VII) corresponding to the -COOH terminal portion of the molecule [(1984) J. Chromatogr.	Lysine	82-85	albumin	Homo sapiens	53-66
3967761-4	1985	The amino acid sequence of the tryptic peptide of Mi/Fg variant that differs from the corresponding fragment of the normal serum albumin shows that the Lys----Glu substitution responsible for this variant is located at position 573.	Lysine	152-155	albumin	Homo sapiens	123-136
3965857-8	1985	Carbamylation of lysine residues of apoB in vivo, abnormal catabolism of LDL due to the absence of functional renal tissue, or triglyceride enrichment of LDL are among the possible explanations for the abnormal properties of uremic LDL.	Lysine	17-23	apolipoprotein B	Homo sapiens	36-40
3928261-5	1985	The gene-enzyme relationships have been determined for ten of the lysine loci which include two unlinked gene functions required for each of AA reductase (LYS2 and LYS5) and Saccharopine reductase (LYS9 and LYS14).	Lysine	66-72	Lys14p	Saccharomyces cerevisiae S288C	207-212
3964822-3	1985	The highly conserved glycosylation site at amino acid position 86 was changed from asparagine to lysine to remove the carbohydrate moiety from the first external domain of the H-2 molecule, and the phenylalanine at position 116 was changed to tyrosine, replacing the Ld residue with the Kb type amino acid analogous to Kb mutants: bm5 and bm16 mutants derived from the Kb antigen have the Ld-type residue at this position.	Lysine	97-103	histocompatibility-2, MHC	Mus musculus	176-179
3005181-1	1985	The di-acid metabolite of enalapril, enalaprilat, and its lysine analogue lisinopril are potent inhibitors of angiotensin converting enzyme (ACE); they do not contain sulphydryl groups.	Lysine	58-64	angiotensin I converting enzyme	Homo sapiens	110-139
3005181-1	1985	The di-acid metabolite of enalapril, enalaprilat, and its lysine analogue lisinopril are potent inhibitors of angiotensin converting enzyme (ACE); they do not contain sulphydryl groups.	Lysine	58-64	angiotensin I converting enzyme	Homo sapiens	141-144
6097248-2	1984	Partial nucleotide sequencing of the cloned DNA revealed the location of a 120-bp long intron between Lys-41 and Asn-42 of the ANF precursor.	Lysine	102-105	natriuretic peptide A	Homo sapiens	127-130
4022111-3	1985	Hexanal is rapidly autoxidized in mixture with nonlipidic substrates even at 25 degrees C. The formation of peroxides follows the kinetics of a first order reaction with respect to hexanal (k1 about 10(-5) min-1), and is higher in mixture with casein or lysine-impregnated cellulose than with cellulose.	Lysine	254-260	CD59 molecule (CD59 blood group)	Homo sapiens	206-211
6490722-3	1984	Fibroblast adhesion to fibronectin is competitively inhibited by certain synthetic peptides, including the decapeptide Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro, which appears to contain the cell recognition sequence.	Lysine	151-154	fibronectin 1	Homo sapiens	23-34
6094585-11	1984	This is the first report of a specific, characterized lysine modification on calmodulin, and it is possible that other phenothiazine-binding proteins may also exhibit similar selectivity for acylation.	Lysine	54-60	calmodulin	Bos taurus	77-87
6543039-1	1984	The potentiating effect of fibrin monomer on plasminogen activation by tissue-type plasminogen activator is much more important with lys-plasminogen than with mini-plasminogen (which lacks the high affinity lysine-binding site important for binding to fibrin).	Lysine	207-213	plasminogen activator, tissue type	Homo sapiens	71-104
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Lysine	98-104	insulin	Homo sapiens	36-46
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Lysine	98-104	insulin	Homo sapiens	39-46
6207021-1	1984	Large orthorhombic crystals of the complex formed by bovine trypsinogen and a semisynthetic homologous bovine pancreatic trypsin inhibitor with the reactive-site lysine residue replaced by an arginine residue [( Arg15]PTI) have been obtained which are isomorphous with the crystals of PTI-trypsinogen [Bode, W., Schwager, P. and Huber, R. (1978) J. Mol.	Lysine	162-168	trophoblast Kunitz domain protein 1	Bos taurus	121-138
6091745-3	1984	Phosvitin contains a core region of 99 amino acids, consisting of 80 serines, grouped in runs of maximally 14 residues interspersed by arginines, lysines, and asparagines.	Lysine	146-153	Casein kinase II subunit beta	Gallus gallus	0-9
6089896-6	1984	We have also demonstrated, using whole intestinal mucosal cells, that lysine and arginine-modified HDL3 inhibited binding of normal 125I-labeled HDL3 to the same extent as normal excess HDL3.	Lysine	70-76	HDL3	Homo sapiens	145-149
6089896-6	1984	We have also demonstrated, using whole intestinal mucosal cells, that lysine and arginine-modified HDL3 inhibited binding of normal 125I-labeled HDL3 to the same extent as normal excess HDL3.	Lysine	70-76	HDL3	Homo sapiens	145-149
6541374-1	1984	Tissue plasminogen activator (t-PA) in plasma was separated from inhibitors by adsorption on lysine-Sepharose.	Lysine	93-99	plasminogen activator, tissue type	Homo sapiens	0-34
6206897-0	1984	Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu----Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn.	Lysine	48-51	tryptophanyl-tRNA synthetase 1	Homo sapiens	26-33
6737432-5	1984	Inhibition of DHFR in a cell-free assay was decreased only 3-fold relative to MTX, indicating that gamma-substitution by up to three lysines is well tolerated for binding.	Lysine	133-140	dihydrofolate reductase	Rattus norvegicus	14-18
6431300-6	1984	We demonstrate here that the ATP analogue p-fluorosulphonylbenzoyl 5"-adenosine (FSBA) inactivates the tyrosine protein kinase activity of p60src by reacting with lysine 295.	Lysine	163-169	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-145
6431300-7	1984	When aligned for maximum sequence identity, lysine 295 of p60src and the lysine in the catalytic subunit which also reacts specifically with FSBA are superimposed precisely.	Lysine	44-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-64
6329312-1	1984	Chemical modification of lysine or arginine residues of apolipoprotein B-100 in human low-density lipoprotein (LDL) with respectively reductive methylation (Me-LDL) or cyclohexanedione treatment (CHD-LDL) was applied to determine the role of these amino acids in LDL recognition by the various liver cell types.	Lysine	25-31	apolipoprotein B	Homo sapiens	56-76
6432779-0	1984	Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.	Lysine	113-119	apolipoprotein A1	Homo sapiens	68-86
6432779-3	1984	The evidence suggests that a single amino acid, lysine 107, has been deleted in the variant apo-A-I of all affected individuals studied from these families, with the remainder of the variant apo-A-I sequence being unaffected.	Lysine	48-54	apolipoprotein A1	Homo sapiens	92-99
6432779-3	1984	The evidence suggests that a single amino acid, lysine 107, has been deleted in the variant apo-A-I of all affected individuals studied from these families, with the remainder of the variant apo-A-I sequence being unaffected.	Lysine	48-54	apolipoprotein A1	Homo sapiens	92-97
6329273-1	1984	The preparation, purification and characterization of the three singly, three doubly and one triply substituted derivatives of cytochrome c modified by pyridoxal phosphate (PLP) at lysine residues are reported.	Lysine	181-187	cytochrome c, somatic	Homo sapiens	127-139
6329273-6	1984	The ability to restore both succinate and ascorbate/TMPD oxidation in cytochrome c-depleted mitochondria decreases in the order: native cytochrome c greater than PLP-Lys-79-cytochrome c greater than PLP-Lys-86-cytochrome c greater than PLP-Lys-79,86-cytochrome c greater than triply substituted derivative.	Lysine	166-169	cytochrome c, somatic	Homo sapiens	70-82
6329273-6	1984	The ability to restore both succinate and ascorbate/TMPD oxidation in cytochrome c-depleted mitochondria decreases in the order: native cytochrome c greater than PLP-Lys-79-cytochrome c greater than PLP-Lys-86-cytochrome c greater than PLP-Lys-79,86-cytochrome c greater than triply substituted derivative.	Lysine	203-206	cytochrome c, somatic	Homo sapiens	70-82
6329273-6	1984	The ability to restore both succinate and ascorbate/TMPD oxidation in cytochrome c-depleted mitochondria decreases in the order: native cytochrome c greater than PLP-Lys-79-cytochrome c greater than PLP-Lys-86-cytochrome c greater than PLP-Lys-79,86-cytochrome c greater than triply substituted derivative.	Lysine	203-206	cytochrome c, somatic	Homo sapiens	70-82
6327714-4	1984	Modification of apo-E2 with cysteamine, which converts the cysteine at position 158 to a positively charged lysine analogue, activates receptor binding approximately 13-fold.	Lysine	108-114	apolipoprotein E	Homo sapiens	16-22
6430701-4	1984	19 of the 23 lysine residues of EF-Tu were labelled under conditions for ternary complex stability.	Lysine	13-19	Tu translation elongation factor, mitochondrial	Homo sapiens	32-37
6443592-7	1984	The two residues at the C-terminus of E3, Lys-Arg, are removed during or shortly after cleavage from PE2.	Lysine	42-45	ETS2 repressor factor	Homo sapiens	101-104
6547060-7	1984	The kinetics of phosphorylation of shortened peptides corresponding to this 18-residue sequence together with those of another related sequence, RPQRAKAKTTKATSNVFS , indicated that the myosin light chain kinase had a relatively stronger dependence on lysine residues, whereas the cAMP-dependent protein kinase depends more on arginine residues.	Lysine	251-257	myosin light chain kinase	Gallus gallus	185-210
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Lysine	79-82	calmodulin 1	Homo sapiens	40-50
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	cytochrome c, somatic	Homo sapiens	10-22
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	cytochrome c, somatic	Homo sapiens	87-99
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Lysine	79-82	calmodulin 1	Homo sapiens	52-55
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Lysine	139-142	calmodulin 1	Homo sapiens	40-50
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Lysine	139-142	calmodulin 1	Homo sapiens	52-55
6711801-6	1984	Thus, the modification at Lys-16 of the alpha-chain is a major factor in the inhibition of sickling by glyceraldehyde.	Lysine	26-29	Fc gamma receptor and transporter	Homo sapiens	40-51
6422989-0	1984	Selective chemical modification of a functionally linked lysine in cytochrome P-450 LM2.	Lysine	57-63	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-83
6706980-1	1984	Approximately 10% of the albumin in normal human serum is modified by nonenzymatic glycosylation, primarily at the epsilon-amino group of lysine residue 525.	Lysine	138-144	albumin	Homo sapiens	25-32
6706980-9	1984	These differences in affinity suggest that lysine 525 plays a key role in the binding of physiologically important ligands to albumin.	Lysine	43-49	albumin	Homo sapiens	126-133
6326126-5	1984	Spt2 and spt3 mutations, known to suppress Ty insertions and their solo delta derivatives at HIS4, can also suppress at least one of the Ty insertions (Ty61) at LYS2 and can also suppress the Lys- phenotype of a solo delta derivative of another Ty insertion (Ty128) at LYS2.	Lysine	192-195	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Saccharomyces cerevisiae S288C	93-97
6143761-5	1984	Labeled kinins were eluted in the following order: bradykinin, Lys-bradykinin, and Met-Lys-bradykinin.	Lysine	63-66	kininogen 1	Homo sapiens	67-77
6143761-5	1984	Labeled kinins were eluted in the following order: bradykinin, Lys-bradykinin, and Met-Lys-bradykinin.	Lysine	63-66	kininogen 1	Homo sapiens	67-77
6321602-8	1984	A unique sequence Gly-Gly-Lys-Gly-Glu-Lys identified this fragment as alpha 2(I) collagen.	Lysine	26-29	collagen type I alpha 2 chain	Homo sapiens	70-89
6321602-8	1984	A unique sequence Gly-Gly-Lys-Gly-Glu-Lys identified this fragment as alpha 2(I) collagen.	Lysine	38-41	collagen type I alpha 2 chain	Homo sapiens	70-89
6587440-2	1984	In organ baths arginine (A)- and lysine (L)-VP in concentrations of 0.6 to 100 ng/ml stimulated small human myometrial strips and uterine artery preparations to a similar degree.	Lysine	33-39	arginine vasopressin	Homo sapiens	44-46
6142022-2	1984	It shows a potency for inhibition of growth hormone release in vitro about one-tenth that of the corresponding saturated analog, cyclo-(Pro-Phe-D-Trp-Lys-Thr-Phe) (I).	Lysine	150-153	growth hormone 1	Homo sapiens	37-51
6364829-7	1984	The lysine, desamino-, and 1,6-aminosuberyl analogues of vasopressin, vasotocin, and AVP are equipotent peptides, whereas the desglycinamide analogue, pressinoic acid, and angiotensin II were inactive.	Lysine	4-10	arginine vasopressin	Rattus norvegicus	57-68
6524712-6	1984	By homology with the sequence of human serum transferrin (MacGillivray et al., 1982) the Lys:Arg and Asp:Gly substitutions probably occur at residues 527 and 446, respectively, from the N-terminus.	Lysine	89-92	transferrin	Homo sapiens	45-56
6317754-6	1983	However, a periodate-lysine fixative containing both paraformaldehyde and glutaraldehyde preserved esterase and showed good to excellent staining of Lyt-1, Thy-1.2, RA32C2, and F4/80.	Lysine	21-27	thymus cell antigen 1, theta	Mus musculus	156-163
6714935-11	1984	Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine.	Lysine	135-141	carboxypeptidase Q	Homo sapiens	0-14
6201567-0	1984	Interferon response to poly IC/poly-L-lysine in normal and lymphocyte-suppressed primates.	Lysine	31-44	interferon alpha 1	Homo sapiens	0-10
6201567-1	1984	Grivet monkeys immunosuppressed with either cyclophosphamide or methylprednisolone retain their capacity to produce interferon in response to poly I:C/poly-L-lysine (poly ICL).	Lysine	151-164	interferon alpha 1	Homo sapiens	116-126
6541917-1	1984	Using the ultrafiltration flat chamber method the binding of N-methylglucamine, meglumine amido trizoate, lysine amido trizoate, diatrizoic acid and L-lysine to human serum albumin (HSA) was investigated.	Lysine	149-157	albumin	Homo sapiens	167-180
6097487-1	1984	The pyridoxal phosphate (PLP) modification of the lysine amino groups in cytochrome c causes decrease in the reaction rate with cytochrome c oxidase.	Lysine	50-56	cytochrome c, somatic	Homo sapiens	73-85
6097487-1	1984	The pyridoxal phosphate (PLP) modification of the lysine amino groups in cytochrome c causes decrease in the reaction rate with cytochrome c oxidase.	Lysine	50-56	cytochrome c, somatic	Homo sapiens	128-140
6097487-11	1984	c. The positively charged cytochrome c lysines 86 and 79 form two from four or five predicted complementary charge interactions with carboxyl groups on cytochrome c oxidase.	Lysine	39-46	cytochrome c, somatic	Homo sapiens	26-38
6097487-11	1984	c. The positively charged cytochrome c lysines 86 and 79 form two from four or five predicted complementary charge interactions with carboxyl groups on cytochrome c oxidase.	Lysine	39-46	cytochrome c, somatic	Homo sapiens	152-164
6207512-10	1984	One of the ovine brain peptides with GH-releasing activity was partially characterized as His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr- Lys-Arg-Try-Asn-Lys-Glu-Met- Ala-Lys--which is similar to rat GRF and porcine VIP having His at the N-terminus.	Lysine	131-134	vasoactive intestinal peptide	Rattus norvegicus	209-212
6435632-3	1983	Incorporation studies with 3H-leucine or 3H-lysine indicated the active synthesis of metallothionein after 10 hrs of cadmium injection.	Lysine	41-50	metallothionein 4	Gallus gallus	85-100
6314279-1	1983	The soybean chloroplast psb A gene (photosystem II thylakoid membrane protein of Mr 32 000, lysine-free) and the trn H gene (tRNAHisGUG), which both map in the large single copy region adjacent to one of the inverted repeat structures (IR1), have been sequenced including flanking regions.	Lysine	92-98	psbA	Glycine max	24-29
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Lysine	195-198	insulin	Homo sapiens	146-156
6317019-0	1983	Critical lysine residue at the chloride binding site of angiotensin converting enzyme.	Lysine	9-15	angiotensin I converting enzyme	Homo sapiens	56-85
6363674-2	1983	The solubility of insulin may be improved with the addition of small amounts of aspartic acid, glutamic acid, EDTA (ethylenediaminetetraacetic acid), lysine, Tris buffer, or bicarbonate buffer.	Lysine	150-156	insulin	Homo sapiens	18-25
6363674-4	1983	Buffered physiological (pH 7.4) saline solutions containing 0.001-0.003 M lysine in the presence of 0.005 M EDTA or 0.01 M lysine in the absence of EDTA improve insulin solubility and are effective in minimizing aggregation.	Lysine	74-80	insulin	Homo sapiens	161-168
6363674-4	1983	Buffered physiological (pH 7.4) saline solutions containing 0.001-0.003 M lysine in the presence of 0.005 M EDTA or 0.01 M lysine in the absence of EDTA improve insulin solubility and are effective in minimizing aggregation.	Lysine	123-129	insulin	Homo sapiens	161-168
6316148-4	1983	These derivatives of beta-endorphin are released by an endopeptidase that appears to catalyse cleavage on the carboxyl side of paired lysine residues, followed by the action of a carboxypeptidase B-like enzyme (Fig.	Lysine	134-140	proopiomelanocortin	Bos taurus	21-35
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Lysine	122-125	calmodulin	Bos taurus	216-226
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Lysine	260-263	calmodulin	Bos taurus	216-226
6418159-0	1983	Role of lysine residues in the binding of glyceraldehyde-3-phosphate dehydrogenase to human erythrocyte membranes.	Lysine	8-14	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-82
6413255-4	1983	It is concluded that the positively charged lysine residues of cytochrome P450 are important for metabolism of 7-ethoxycoumarin by cytochrome P450.	Lysine	44-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	63-78
6413637-5	1983	Note added in proof: Preliminary binding experiments using high concentrations of [3H]leucine, lysine TCGF with a low specific radioactivity indicate the existence of a sizeable pool of receptor sites with an affinity 2,000-10,000 times lower than that of the high affinity receptors measured in Fig.	Lysine	95-101	interleukin 2	Homo sapiens	102-106
6413255-4	1983	It is concluded that the positively charged lysine residues of cytochrome P450 are important for metabolism of 7-ethoxycoumarin by cytochrome P450.	Lysine	44-50	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-146
6347401-8	1983	The plasmin esterase inhibitors, epsilon-amino-n-caproic acid, tranexamic acid, and L-lysine, previously established to reverse the MMI response to MIF, FBP, and C3 activators were found to inhibit both Fc- and C3-dependent phagocytosis.	Lysine	84-92	fructose-1,6-bisphosphatase 1	Ovis aries	153-156
6347401-8	1983	The plasmin esterase inhibitors, epsilon-amino-n-caproic acid, tranexamic acid, and L-lysine, previously established to reverse the MMI response to MIF, FBP, and C3 activators were found to inhibit both Fc- and C3-dependent phagocytosis.	Lysine	84-92	complement C3	Ovis aries	203-213
6863249-7	1983	An additional hydrogen bond can be formed by bridging of the epsilon-amino group of beta-66 (Lys) between a heme propionate from cytochrome b5 and a beta-chain heme propionate.	Lysine	93-96	amyloid beta precursor protein	Homo sapiens	147-153
6873065-5	1983	The imidate compound was found to react with a high specificity with only one lysine residue of ribosomal protein L7/L12.	Lysine	78-84	ribosomal protein L7	Homo sapiens	96-116
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	70-73	Fc gamma receptor and transporter	Homo sapiens	8-19
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Lysine	95-98	neurotensin	Homo sapiens	28-39
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Lysine	95-98	tachykinin precursor 1	Homo sapiens	44-55
6300187-8	1983	In all cases, the binding activity of the apo-E2 was increased 10- to 20-fold by treating the apoproteins with cysteamine, a reagent that converts cysteine residues to positively charged lysine analogues.	Lysine	187-193	apolipoprotein E	Homo sapiens	42-48
6405795-9	1983	On this basis, intact HDL3 was reacted with TNBS at 20 degrees C for 80 min and it could be considered that at least 10 of 22 primary amino groups of apolipoprotein A-I and 10 of 18 lysine residues of apolipoprotein A-II were exposed on the surface of HDL3 particles.	Lysine	182-188	HDL3	Homo sapiens	22-26
6187854-10	1983	The stimulating determinant is present on the HA of all natural virus isolates of the H1 subtype, is absent from virus isolates of the H2 and H3 subtypes, and is abolished if glutamic acid at position 115 of the HA1 polypeptide of PR8 is replaced by lysine.	Lysine	250-256	Rho GTPase activating protein 45	Mus musculus	212-215
6877243-2	1983	CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine.	Lysine	189-195	C-reactive protein	Homo sapiens	0-3
6219709-0	1983	The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen.	Lysine	16-22	fibrinogen beta chain	Homo sapiens	81-91
6219709-1	1983	The importance of the lysine binding sites of human plasmin for its ability to digest human fibrinogen has been assessed by analyzing the nature and rate of the products formed in the presence of epsilon-aminocaproic acid.	Lysine	22-28	fibrinogen beta chain	Homo sapiens	92-102
6219709-3	1983	The presence of epsilon-aminocaproic acid, at concentrations ranging from 0.5-5.0 mM, results in progressively stronger inhibition of the digestion of fibrinogen and in appearance of fibrinogen degradation products Y, D and E, for both Lys77-plasmin, and Val442-plasmin, showing the importance of lysine binding regions in this property.	Lysine	297-303	fibrinogen beta chain	Homo sapiens	183-193
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	70-73	Fc gamma receptor and transporter	Homo sapiens	45-56
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	Fc gamma receptor and transporter	Homo sapiens	8-19
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	Fc gamma receptor and transporter	Homo sapiens	45-56
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	Fc gamma receptor and transporter	Homo sapiens	8-19
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	Fc gamma receptor and transporter	Homo sapiens	45-56
6863249-5	1983	A fourth hydrogen bond involves alpha-61 (Lys) bridging between a heme propionate from cytochrome b5 and a heme propionate from the alpha-chain.	Lysine	42-45	Fc gamma receptor and transporter	Homo sapiens	132-143
6405197-0	1983	Effect of chemical modification of arginine and lysine residues of fibronectin on its antigenic and gelatin-binding activity.	Lysine	48-54	fibronectin 1	Homo sapiens	67-78
6864486-2	1983	The modification proceeds through trinitrophenylation of a lysine residue of albumin and monoaddition of the byproduct, sulfite ion, to the trinitrophenylalbumin, as reported previously.	Lysine	59-65	albumin	Homo sapiens	77-84
6864486-7	1983	Acetylation of the lysine-199 residue with aspirin and 5-nitroaspirin decreased the trinitrophenylation rate of albumin with I.	Lysine	19-25	albumin	Homo sapiens	112-119
6301552-3	1983	A comparison with the relaxation behavior of cytochrome c modified by 4-carboxy-3,5-dinitrophenyl at Lys-13 shows that the oxidase induces a conformation in native cytochrome c that is closely related to that of the derivative.	Lysine	101-104	cytochrome c, somatic	Homo sapiens	45-57
6687626-7	1983	As is the case for the bovine arginine-vasopressin-neurophysin II (AVP-NpII) precursor, the signal sequence of the OT-NpI precursor is immediately followed by the nonapeptide hormone which is connected to neurophysin I by a Gly-Lys-Arg sequence.	Lysine	228-231	oxytocin/neurophysin I prepropeptide	Bos taurus	115-121
6301552-3	1983	A comparison with the relaxation behavior of cytochrome c modified by 4-carboxy-3,5-dinitrophenyl at Lys-13 shows that the oxidase induces a conformation in native cytochrome c that is closely related to that of the derivative.	Lysine	101-104	cytochrome c, somatic	Homo sapiens	164-176
6401433-3	1983	Approximately 30,000 sites/cell belonged to the high-affinity class with a Kd of about 3 x 10(-8) M. Modification of two lysine residues of thrombin with pyridoxal 5"-phosphate (PLP2-thrombin) destroyed the high-affinity binding and about three-fourths of the low-affinity bindings.	Lysine	121-127	coagulation factor II, thrombin	Homo sapiens	140-148
6401433-3	1983	Approximately 30,000 sites/cell belonged to the high-affinity class with a Kd of about 3 x 10(-8) M. Modification of two lysine residues of thrombin with pyridoxal 5"-phosphate (PLP2-thrombin) destroyed the high-affinity binding and about three-fourths of the low-affinity bindings.	Lysine	121-127	coagulation factor II, thrombin	Homo sapiens	183-191
6401433-4	1983	When the lysine residue of thrombin involved in heparin binding was protected with heparin against chemical modification (PLP-thrombin), the modified enzyme remained similar to the native one with respect to cellular binding, with some loss of low-affinity binding only.	Lysine	9-15	coagulation factor II, thrombin	Homo sapiens	27-35
6401433-4	1983	When the lysine residue of thrombin involved in heparin binding was protected with heparin against chemical modification (PLP-thrombin), the modified enzyme remained similar to the native one with respect to cellular binding, with some loss of low-affinity binding only.	Lysine	9-15	coagulation factor II, thrombin	Homo sapiens	126-134
6405197-1	1983	The effect of chemical modification of arginine and lysine residues of fibronectin on its antigenic and gelatin-binding activity was studied by enzyme immunoassay techniques.	Lysine	52-58	fibronectin 1	Homo sapiens	71-82
6405655-7	1983	The labeled iodonitroanisole has been used as a photoactive reagent to label a protein (bovine serum albumin), showing that under the irradiation conditions used, the label is incorporated into the polypeptide mainly through modification of epsilon-amino groups of the lysine residues.	Lysine	269-275	albumin	Homo sapiens	95-108
6188729-1	1983	Poly-L-lysine (PPL) has been used to coat glass slides in the preparation of tissue sections for immunocytochemical staining.	Lysine	0-13	periplakin	Homo sapiens	15-18
6293985-0	1982	Beta-endorphin: synthesis and properties of analogs with replacement of lysine residues by arginine.	Lysine	72-78	proopiomelanocortin	Homo sapiens	0-14
6826664-4	1983	The mutant Lys-101 only showed an altered Lysyl-tRNA synthetase.	Lysine	11-14	lysine--tRNA ligase	Cricetulus griseus	42-63
7155144-1	1982	Schiff bases condensible at pH 7.0-10 after prolonged incubation with neighbouring histidine residues to yield cyclic compounds absorbing at 330 nm are formed by means of four molecules of pyridoxal-5"-phosphate (PLP) interacting with epsilon-NH2 groups of lysine in bovine serum albumin.	Lysine	257-263	albumin	Homo sapiens	280-287
6291584-9	1982	In the presence of cytochrome c, EDC promotes formation of amide cross-links between lysine amino groups on cytochrome c and their complementary carboxyl groups on cytochrome c oxidase.	Lysine	85-91	cytochrome c, somatic	Homo sapiens	19-31
6816218-3	1982	The N-terminal amino acid sequence of rabbit serum transferrin is: Val-Thr-Glu-Lys-Thr-Val-Asn-Trp-?-Ala-Val-Ser.	Lysine	79-82	transferrin	Homo sapiens	51-62
6291584-9	1982	In the presence of cytochrome c, EDC promotes formation of amide cross-links between lysine amino groups on cytochrome c and their complementary carboxyl groups on cytochrome c oxidase.	Lysine	85-91	cytochrome c, somatic	Homo sapiens	108-120
6291584-9	1982	In the presence of cytochrome c, EDC promotes formation of amide cross-links between lysine amino groups on cytochrome c and their complementary carboxyl groups on cytochrome c oxidase.	Lysine	85-91	cytochrome c, somatic	Homo sapiens	108-120
7049235-2	1982	N-[7-(Dimethylamino)-4-methylcoumarinyl]maleimide, coupled to Cys-70 of L10, served as a donor for fluorescein which was attached to Lys-51 or to the N terminus of L7/L12.	Lysine	133-136	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	72-75
6214865-0	1982	Fractionation of plasmic fibrinogen digest on lysine-agarose.	Lysine	46-52	fibrinogen beta chain	Homo sapiens	25-35
6809558-2	1982	Conformational changes of hexokinase from ascites tumor cells have been studied by chemical modification of lysine residues with imidoesters with the following results: 1) The membrane-bound enzyme, in contrast to the soluble enzyme, is not inactivated by treatment with dimethyl suberimidate, which suggests (a) lysine residue(s) essential for the activity that is protected in the membrane-bound enzyme.	Lysine	108-114	hexokinase 1	Homo sapiens	26-36
6809558-2	1982	Conformational changes of hexokinase from ascites tumor cells have been studied by chemical modification of lysine residues with imidoesters with the following results: 1) The membrane-bound enzyme, in contrast to the soluble enzyme, is not inactivated by treatment with dimethyl suberimidate, which suggests (a) lysine residue(s) essential for the activity that is protected in the membrane-bound enzyme.	Lysine	313-319	hexokinase 1	Homo sapiens	26-36
6124421-2	1982	Human liver alanine aminopeptidase (EC 3.4.11.14; L-alpha-aminoacyl-peptide hydrolase) catalyzes the stepwise hydrolysis of methionyl-lysyl-bradykinin to yield methionine, lysine, and the limit nonapeptide, bradykinin which is resistant to further hydrolytic cleavage by this enzyme.	Lysine	172-178	carboxypeptidase Q	Homo sapiens	20-34
6124421-2	1982	Human liver alanine aminopeptidase (EC 3.4.11.14; L-alpha-aminoacyl-peptide hydrolase) catalyzes the stepwise hydrolysis of methionyl-lysyl-bradykinin to yield methionine, lysine, and the limit nonapeptide, bradykinin which is resistant to further hydrolytic cleavage by this enzyme.	Lysine	172-178	kininogen 1	Homo sapiens	140-150
7094206-6	1982	The histones were found to contain epsilon-N-mono, di and trimethyllysine derivatives; whereas the non-histone fraction contained these lysine derivatives and additional basic amino acid identified as NG,NG-dimethylarginine.	Lysine	67-73	H2B clustered histone 1	Rattus norvegicus	4-11
6279160-9	1982	Succinylation of the 19th, and final, lysine residue of cytochrome c produced unfolding even in the absence of urea, whereas reaction of the first 18 had very little effect.	Lysine	38-44	cytochrome c, somatic	Homo sapiens	56-68
6811468-1	1982	A protected tridecapeptide of the sequence Boc-Lys(2CIZ)-Arg(Tos)-Leu-Glu (OcHex)-Trp(For)-Ile-Ala-Ala-Ser(Bzl)-Arg(Tos)-Asn-Lys(2CIZ)-Gly-OH, representing residues 43-55 of the variable region of the heavy chain of mouse myeloma protein M603, was synthesized.	Lysine	47-50	zinc finger protein 384	Mus musculus	52-55
7094206-10	1982	After hydrolysis, the non-histones were found to contain a labeled lysine and arginine derivative, but in the histone fraction only labeled lysine was found.	Lysine	67-73	H2B clustered histone 1	Rattus norvegicus	26-33
7276568-3	1981	C-reactive protein previously was shown to selectively and reversibly precipitate with certain small polymers of arginine and lysine.	Lysine	126-132	C-reactive protein	Homo sapiens	0-18
7044895-1	1981	A gene has been constructed which codes for an analog of human proinsulin in which the normal 35-amino acid connecting peptide is replaced by a "mini-C" peptide of six amino acids (Arg-Arg-Gly-Ser-Lys-Arg).	Lysine	197-200	insulin	Homo sapiens	63-73
6273286-5	1981	361, 1077--1091) have recently found that a cytochrome c derivative trifluoroacetylated at all 19 lysine amino groups decreased the reaction rate between ferrocytochrome c and cytochrome c oxidase nearly as much as native ferricytochrome c, a known inhibitor that binds cytochrome c oxidase.	Lysine	98-104	cytochrome c, somatic	Homo sapiens	44-56
6273286-5	1981	361, 1077--1091) have recently found that a cytochrome c derivative trifluoroacetylated at all 19 lysine amino groups decreased the reaction rate between ferrocytochrome c and cytochrome c oxidase nearly as much as native ferricytochrome c, a known inhibitor that binds cytochrome c oxidase.	Lysine	98-104	cytochrome c, somatic	Homo sapiens	159-171
6273286-5	1981	361, 1077--1091) have recently found that a cytochrome c derivative trifluoroacetylated at all 19 lysine amino groups decreased the reaction rate between ferrocytochrome c and cytochrome c oxidase nearly as much as native ferricytochrome c, a known inhibitor that binds cytochrome c oxidase.	Lysine	98-104	cytochrome c, somatic	Homo sapiens	159-171
6794630-0	1981	Reduced immunoregulatory potency of low density lipoproteins with selectively modified arginine and lysine residues of apolipoprotein B.	Lysine	100-106	apolipoprotein B	Homo sapiens	119-135
6790534-5	1981	Rat alpha-1-antitrypsin showed significant differences in amino acid composition when compared to human alpha-1-antitrypsin, particularly in lysine, glutamic acid, arginine, methionine, and tyrosine content.	Lysine	141-147	serpin family A member 1	Homo sapiens	4-23
6117008-2	1981	gamma-Glutamylamine cyclotransferase, an enzyme found in a number of animal tissues and cells, catalyzes the conversion of epsilon-(L-gamma-glutamyl)-L-lysine to free lysine and 5-oxo-L-proline as well as the release of free amines and the formation of 5-oxo-L-proline from a variety of other L-gamma-glutamylamines.	Lysine	152-158	gamma-glutamylamine cyclotransferase	Homo sapiens	0-36
7287672-18	1981	The molar ratio of the products of carboxyamidomethylation were 52.3%, 21.7%, 21.0%, and 4.8% for 3-CAM-His, 1,3-di-CAM-His, 1-CAM-His, and di-CM-Lys, respectively.	Lysine	145-149	calmodulin 3	Homo sapiens	116-119
7295647-4	1981	[Lys(me3)]n alters the conformation of some polynucleotides differently from (Lys)n under non- psi conditions.	Lysine	1-4	malic enzyme 3	Bos taurus	5-8
7295647-8	1981	(Lys)n forms psi - structures with (dA-dT)n and (dG-dC)n. [Lys(Me3)]n forms psi + structures with (dA-dT)n. Between 0.05 and 0.3 M NaCl, [Lys(Me3)]n forms psi+ structures with (dG-dC)n, while between 0.35 and 0.45 M NaCl, it forms a psi - structure with (dG-dC)n. Neither (Lys)n nor [Lys(Me3)]n forms psi structures with (dA)n.(dT)n or (dG)n.(dC)n. These results, in conjunction with the work of others on reconstitution of nucleosome-like particles from synthetic polynucleotides, suggest that the ability of DNA and histones to form nucleosomes is related to the formation of psi structures.	Lysine	1-4	malic enzyme 3	Bos taurus	63-66
7295647-8	1981	(Lys)n forms psi - structures with (dA-dT)n and (dG-dC)n. [Lys(Me3)]n forms psi + structures with (dA-dT)n. Between 0.05 and 0.3 M NaCl, [Lys(Me3)]n forms psi+ structures with (dG-dC)n, while between 0.35 and 0.45 M NaCl, it forms a psi - structure with (dG-dC)n. Neither (Lys)n nor [Lys(Me3)]n forms psi structures with (dA)n.(dT)n or (dG)n.(dC)n. These results, in conjunction with the work of others on reconstitution of nucleosome-like particles from synthetic polynucleotides, suggest that the ability of DNA and histones to form nucleosomes is related to the formation of psi structures.	Lysine	1-4	malic enzyme 3	Bos taurus	142-145
7295647-8	1981	(Lys)n forms psi - structures with (dA-dT)n and (dG-dC)n. [Lys(Me3)]n forms psi + structures with (dA-dT)n. Between 0.05 and 0.3 M NaCl, [Lys(Me3)]n forms psi+ structures with (dG-dC)n, while between 0.35 and 0.45 M NaCl, it forms a psi - structure with (dG-dC)n. Neither (Lys)n nor [Lys(Me3)]n forms psi structures with (dA)n.(dT)n or (dG)n.(dC)n. These results, in conjunction with the work of others on reconstitution of nucleosome-like particles from synthetic polynucleotides, suggest that the ability of DNA and histones to form nucleosomes is related to the formation of psi structures.	Lysine	1-4	malic enzyme 3	Bos taurus	142-145
7253051-5	1981	In nonsurvivors threonine, valine, leucine, phenylalanine, lysine, and histidine all rose significantly (p less than or equal to 0.025) with albumin infusion.	Lysine	59-65	albumin	Homo sapiens	141-148
7287672-18	1981	The molar ratio of the products of carboxyamidomethylation were 52.3%, 21.7%, 21.0%, and 4.8% for 3-CAM-His, 1,3-di-CAM-His, 1-CAM-His, and di-CM-Lys, respectively.	Lysine	145-149	calmodulin 3	Homo sapiens	116-119
7028141-1	1981	An intramolecular modification of insulin at the alpha-amino group of glycine (A1) and the epsilon-amino group of lysine (B29) was carried out.	Lysine	114-120	insulin	Homo sapiens	34-41
6270658-3	1981	Peptide Ia was coupled to another synthetic peptide, [Lys(Cit)19,24,28,29]-beta-endorphin-(18-31), by reaction with silver nitrate--N-hydroxysuccinimide in water.	Lysine	54-57	proopiomelanocortin	Homo sapiens	75-89
6268131-0	1981	Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects.	Lysine	71-77	renin	Homo sapiens	112-117
6789830-0	1981	4-Aminobutyrate aminotransferase, the reaction of lysine residues connected with enzymatic activity.	Lysine	50-56	4-aminobutyrate aminotransferase	Homo sapiens	0-32
6112080-4	1981	Direct identification and determination of the reaction products, lysine and/or methionine, were undertaken to establish unequivocally the kinin-converting activity of human pancreas alanine aminopeptidase, which exhibited a pH optimum at pH 7.9.	Lysine	66-72	carboxypeptidase Q	Homo sapiens	191-205
6263321-0	1980	The use of specific lysine modifications to locate the reaction site of cytochrome c with sulfite oxidase.	Lysine	20-26	cytochrome c, somatic	Homo sapiens	72-84
6780552-1	1981	Inhibition of platelet-thrombin interactions by lysine modification.	Lysine	48-54	coagulation factor II, thrombin	Homo sapiens	23-31
6780552-2	1981	The chemical modification of lysine residues in human alpha-thrombin has been used to study the interaction of thrombin with human platelets.	Lysine	29-35	coagulation factor II, thrombin	Homo sapiens	60-68
6780552-2	1981	The chemical modification of lysine residues in human alpha-thrombin has been used to study the interaction of thrombin with human platelets.	Lysine	29-35	coagulation factor II, thrombin	Homo sapiens	111-119
6780552-11	1981	These results provide further support for the hypothesis that residues at the macromolecular binding site of thrombin are involved in the binding of thrombin to platelets and further separate this functional region of thrombin into two lysine-containing subregions, one which is protected from modification by heparin which is involved in high affinity binding, and another which is not protected by heparin which is involved in low affinity binding.	Lysine	236-242	coagulation factor II, thrombin	Homo sapiens	109-117
6780552-11	1981	These results provide further support for the hypothesis that residues at the macromolecular binding site of thrombin are involved in the binding of thrombin to platelets and further separate this functional region of thrombin into two lysine-containing subregions, one which is protected from modification by heparin which is involved in high affinity binding, and another which is not protected by heparin which is involved in low affinity binding.	Lysine	236-242	coagulation factor II, thrombin	Homo sapiens	149-157
6780552-11	1981	These results provide further support for the hypothesis that residues at the macromolecular binding site of thrombin are involved in the binding of thrombin to platelets and further separate this functional region of thrombin into two lysine-containing subregions, one which is protected from modification by heparin which is involved in high affinity binding, and another which is not protected by heparin which is involved in low affinity binding.	Lysine	236-242	coagulation factor II, thrombin	Homo sapiens	149-157
7044004-3	1981	Aminopeptidase preferred Lys-, Phe-, ARg-, and Met-2-naphthylamides as substrates.	Lysine	25-28	carboxypeptidase Q	Homo sapiens	0-14
6262063-2	1980	In inhibiting the increase in cyclic AMP caused by VIP acting through the VIP-preferring receptors, 15-Lys-S5-27 was equipotent with 15-Asn-S5-27, and these analogues were significantly more potent than S5-27.	Lysine	103-106	vasoactive intestinal peptide	Homo sapiens	51-54
6254679-3	1980	Other various proteins, such as histone, lysozyme, cytochrome c, and gamma-globulin could also incorporate Trp-P-2, but poly(L-Arg), poly(L-Lys), and poly(L-Glu) could not.	Lysine	138-143	cytochrome c, somatic	Homo sapiens	51-63
7237270-4	1980	The CB-1 peptide moved rapidly to the cathode in polyacrylamide gel electrophoresis at pH 3.9 and contained nine arginine residues, three lysine residues, and no acidic amino acid residues.	Lysine	138-144	cannabinoid receptor 1	Homo sapiens	4-8
6448639-8	1980	The most notable discrepancy was observed with the D-Val-Leu-Lys derivatives towards thrombin.	Lysine	61-64	coagulation factor II, thrombin	Homo sapiens	85-93
6159774-4	1980	Treatment of plasma from DR with acetone (25% v/v) induced a conversion of HMWK into a state which was non-functional as a cofactor in the surface-dependent activation of factor XII, and the passage of plasma from DR through a lysine-Sepharose column altered the HMWK present to a substance that released kinin only very slowly by incubation with HPK.	Lysine	227-233	kininogen 1	Homo sapiens	263-267
6251864-1	1980	Two arylazidocytochrome c derivatives, one modified at lysine-13 and the second modified at lysine-22, were reacted with beef heart cytochrome c oxidase.	Lysine	55-61	cytochrome c, somatic	Homo sapiens	13-25
6251864-1	1980	Two arylazidocytochrome c derivatives, one modified at lysine-13 and the second modified at lysine-22, were reacted with beef heart cytochrome c oxidase.	Lysine	92-98	cytochrome c, somatic	Homo sapiens	13-25
6251864-2	1980	The lysine-13 modified arylazidocytochrome c was found to cross-link both to the enzyme and with lipid bound to the cytochrome c oxidase complex.	Lysine	4-10	cytochrome c, somatic	Homo sapiens	32-44
6250589-0	1980	Use of specific trifluoroacetylation of lysine residues in cytochrome c to study the reaction with cytochrome b5, cytochrome c1, and cytochrome oxidase.	Lysine	40-46	cytochrome c, somatic	Homo sapiens	59-71
6250589-1	1980	The preparation, purification, and characterization of four new derivatives of cytochrome c trifluoroacetylated at lysines 72, 79, 87, and 88 are reported.	Lysine	115-122	cytochrome c, somatic	Homo sapiens	79-91
6250589-2	1980	The redox reaction rates of these derivatives with cytochrome b5, cytochrome c1 and cytochrome oxidase indicated that the interaction domain on cytochrome c for all three proteins involves the lysines immediately surrounding the heme crevice.	Lysine	193-200	cytochrome c, somatic	Homo sapiens	66-78
6250589-4	1980	Even though lysines 87 and 88 are adjacent to one another, lysine 87 is at the top left of the heme crevice oriented towards the front of cytochrome c, while lysine 88 is oriented more towards the back.	Lysine	59-65	cytochrome c, somatic	Homo sapiens	138-150
7461904-4	1980	In sodium dodecyl phosphate solution at 45 degrees (Lys)n also undergoes a beta-to-helix transition in alkaline solution with a midpoint at pH 9.2, noting that dodecyl phosphoric acid has two dissociation constants with pKa of about 3 and 8.	Lysine	52-55	amyloid beta precursor protein	Homo sapiens	73-79
6159774-6	1980	Previous experiments with rat plasma demonstrated that plasmin and also a plasmin-like factor without affinity for lysine-Sepharose were able to destroy the capacity of HMWK to function as a cofactor in the surface-dependent activation of factor XII, without a corresponding release of kinin.	Lysine	115-121	kininogen 1	Homo sapiens	169-173
7364757-3	1980	Labeled SPF preparations, containing 1 to 2 modified lysine residues/molecule of protein which retained full biological activity, were found to bind only weakly to microsomes under a variety of experimental conditions as determined by sucrose density gradient centrifugation.	Lysine	53-59	SEC14 like lipid binding 2	Homo sapiens	8-11
6777326-6	1980	Protease solubilized NADPH-cytochrome P450 reductase is inactivated by reagents directed to histidine, arginine and lysine residues.	Lysine	116-122	cytochrome p450 oxidoreductase	Homo sapiens	21-52
7378347-7	1980	The remaining 10% of the rhodopsin amino groups are inaccessible to either type of imidate and are largely accounted for by the single lysine residue which specifically binds the chromophore retinal.	Lysine	135-141	rhodopsin	Homo sapiens	25-34
7013400-1	1980	Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of 14C-leucine into islet proteins, releasing lysine as the only basic amino acid.	Lysine	209-215	cathepsin B	Bos taurus	16-27
6155159-1	1980	In each of two families from Sardinia, Italy, we have found segregation for two alpha-chain hemoglobin variants, which we have identified as G Philadelphia [alpha 68 (E17) Asn leads to Lys] and J Sardinia [alpha 50 (CE8) His leads to Asp], respectively.	Lysine	185-188	Fc gamma receptor and transporter	Homo sapiens	80-91
6997877-10	1980	The active-site residues typical of the serine proteases, histidine-57 and serine-195, are replaced in haptoglobin by lysine and alanine, respectively; however, aspartic acid-102 and the trypsin specificity, residue, aspartic acid-189, do occur in haptoglobin.	Lysine	118-124	haptoglobin	Homo sapiens	103-114
6986378-14	1980	It is concluded that the B1 terminal amino and B29 lysine amino groups are both accessible for cross-linking of insulin to the receptor by disuccinimidyl suberate.	Lysine	51-57	insulin	Homo sapiens	112-119
6247646-2	1980	Cytochrome c is modified by covalent binding of pyridoxal phosphate (PLP) to lysine residues.	Lysine	77-83	cytochrome c, somatic	Homo sapiens	0-12
315708-0	1979	An alpha 1-antitrypsin variant, Pi B Alhambra (Lys to Asp, Glu to Asp), with rapid anodal electrophoretic mobility.	Lysine	47-50	serpin family A member 1	Homo sapiens	3-22
6249473-5	1980	The effect of ACTH is similar to the enhancement in PTH-stimulated bone resorption by poly-l-lysine [7].	Lysine	86-99	parathyroid hormone	Homo sapiens	52-55
505412-2	1979	The fibrinogen is characterized by (1) abnormal side-to-side and end-to-end polymerization, (2) abnormal fibrinopeptide release, (3) a delayed gamma-gamma dimerization of the non cross-linked fibrin, (4) a pH optimum of 7--7.8, and (5) a deviation from normal amino acid composition with regard to lysine, aspartic acid, glutamic acid and serine.	Lysine	298-304	fibrinogen beta chain	Homo sapiens	4-14
114208-12	1979	A tryptic peptide, Val-Asp-Lys-Lys, was also isolated from Dob Fd"; this sequence is not found in the variable region of the Dob heavy chain [Steiner, L. A., Garcia Pardo, A., & Margolies, M. N. (1979) Biochemistry (following paper in this issue)] but corresponds to positions 211-214 of the gamma1 constant region.	Lysine	27-30	major histocompatibility complex, class II, DO beta	Homo sapiens	59-62
114208-12	1979	A tryptic peptide, Val-Asp-Lys-Lys, was also isolated from Dob Fd"; this sequence is not found in the variable region of the Dob heavy chain [Steiner, L. A., Garcia Pardo, A., & Margolies, M. N. (1979) Biochemistry (following paper in this issue)] but corresponds to positions 211-214 of the gamma1 constant region.	Lysine	31-34	major histocompatibility complex, class II, DO beta	Homo sapiens	59-62
7359538-2	1980	[5-(N4,N4-Dimethylasparagine),8-lysine]vasopressin, the analogue in which the hydrogen atoms of the -NH2 portion of the primary carboxamide have been replaced by methyl groups, has been synthesized and found to retain about 3% of the antidiuretic potency of lysine-vasopressin (i.e., 5.5 +/- 0.3 units/mg).	Lysine	32-38	arginine vasopressin	Rattus norvegicus	39-50
7359538-2	1980	[5-(N4,N4-Dimethylasparagine),8-lysine]vasopressin, the analogue in which the hydrogen atoms of the -NH2 portion of the primary carboxamide have been replaced by methyl groups, has been synthesized and found to retain about 3% of the antidiuretic potency of lysine-vasopressin (i.e., 5.5 +/- 0.3 units/mg).	Lysine	258-264	arginine vasopressin	Rattus norvegicus	39-50
229893-8	1979	This indicates that the interaction between the two proteins is best described as the sum of n complementary charge interactions, each involving a specific lysine on cytochrome c and a specific carboxyl group on cytochrome b5.	Lysine	156-162	cytochrome c, somatic	Homo sapiens	166-178
464051-3	1979	Synthetic inhibitor studies indicate that mouse acrosin has a serine and histidine at its active site and hydrolyzes the peptide bonds of lysine and arginine but of not phenylalanine.	Lysine	138-144	acrosin prepropeptide	Mus musculus	48-55
157166-0	1979	On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen.	Lysine	40-46	fibrinogen beta chain	Homo sapiens	125-135
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	fibrinogen beta chain	Homo sapiens	0-10
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	fibrinogen beta chain	Homo sapiens	12-22
157166-7	1979	Thus the fibrinogen molecule contains several complementary sites to the lysine-binding sites located both in its NH2-terminal and COOH-terminal regions; these sites are to a large extent.	Lysine	73-79	fibrinogen beta chain	Homo sapiens	9-19
214557-3	1978	The residue in position 15 of secretin, aspartic acid, was replaced by lysine, which occupies that position in the vasoactive intestinal polypeptide (VIP), a member of the secretin family.	Lysine	71-77	vasoactive intestinal peptide	Rattus norvegicus	115-148
454678-6	1979	The stimulatory action of angiotensin II was additive to that of L-lysine, and 3",5"-adenosine cyclic monophosphate, suggesting a different mechanism of action.	Lysine	65-73	angiotensinogen	Rattus norvegicus	26-40
311784-2	1978	Native alpha-1-antitrypsin has a mass ratio (Mr) of 54,000, an amino-terminal glx, and a carboxy-terminal lys residue.	Lysine	106-109	serpin family A member 1	Homo sapiens	7-26
446405-0	1979	Enhancement of parathyroid hormone-stimulated bone resorption by poly-L-lysine.	Lysine	65-78	parathyroid hormone	Rattus norvegicus	15-34
446405-1	1979	Poly-L-lysine (PL II; mol wt, 1000-4000) was added to fetal rat bones cultured in a chemically defined medium (BGJ) containing bovine serum albumin in the presence and absence of parathyroid hormone (PTH).	Lysine	0-13	prolactin family 3, subfamily B, member 1	Rattus norvegicus	15-20
226161-2	1979	Treatment of CNBr peptides 66--80, 81--104 and 66--104 from cytochrome c with t-butyloxycarbonyl azide leads to selective acylation of the epsilon-amino groups of lysine residues and the phenolic hydroxyl groups of tyrosine residues with less than 25% acylation of the alpha-amino groups.	Lysine	163-169	cytochrome c, somatic	Homo sapiens	60-72
310316-10	1978	Based upon these studies and previous investigations of our laboratory, it was concluded that (1) alpha1-antitrypsin is a lysyl inhibitor type (i.e., the reactive site is a Lys-X bond), (2) its interaction with elastase follows a pattern similar to trypsin and chymotrypsin, and (3) the positively charged epsilon-NH2 group of lysine is essential for the maintenance of elastase inhibitory capacity.	Lysine	327-333	serpin family A member 1	Homo sapiens	98-116
214557-3	1978	The residue in position 15 of secretin, aspartic acid, was replaced by lysine, which occupies that position in the vasoactive intestinal polypeptide (VIP), a member of the secretin family.	Lysine	71-77	vasoactive intestinal peptide	Rattus norvegicus	150-153
150419-2	1978	Extended plasmic digestions of human fibrin containing four epsilon-(gamma-glutamyl)lysine cross-links per molecule produced a peptide of alpha-chain origin (Mr congruent to 21,000) which was comprised of a small donor peptide cross-linked to the acceptor site peptide from the middle of the alpha-chain.	Lysine	84-90	Fc gamma receptor and transporter	Homo sapiens	138-149
309873-4	1978	A part of the lysine-rich histones H1 and H2B, however, seems to be synthesized, even in the absence of DNA synthesis.	Lysine	14-20	histone cluster 1, H2bg	Rattus norvegicus	42-45
151403-1	1978	Peripheral blood lymphocytes from a total of 300 subjects including normal controls and patients with malignant and non-malignant disorders were investigated to determine their ability to agglutinate with Poly-l-lysine 3400 (PAL-test).	Lysine	205-218	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	225-228
210168-1	1978	Differential chemical modification of lysine residues in free and oxidase-bound cytochrome c.	Lysine	38-44	cytochrome c, somatic	Homo sapiens	80-92
207344-11	1978	However, in the lipoproteins apoA-II, which contains lysine but no arginine, was cleaved more rapidly and extensively by agarose-trypsin than apoA-I.	Lysine	53-59	apolipoprotein A1	Homo sapiens	29-35
209818-0	1978	Effect of specific lysine modification on the reduction of cytochrome c by succinate-cytochrome c reductase.	Lysine	19-25	cytochrome c, somatic	Homo sapiens	59-71
209818-0	1978	Effect of specific lysine modification on the reduction of cytochrome c by succinate-cytochrome c reductase.	Lysine	19-25	cytochrome c, somatic	Homo sapiens	85-97
209818-3	1978	The reaction rates of cytochrome c derivatives modified at single lysine residues to form trifluoroacetylated or trifluoromethylphenylcarbamylated cytochromes c were studied to determine the role of individual lysines in the reaction.	Lysine	66-72	cytochrome c, somatic	Homo sapiens	22-34
209452-2	1978	The alpha-lactalbumin was specifically linked to the lysine residue of insulin or to the alpha-amino group of epidermal growth factor.	Lysine	53-59	lactalbumin alpha	Homo sapiens	4-21
656055-0	1978	Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin.	Lysine	0-6	albumin	Homo sapiens	28-41
656055-7	1978	The results indicate that bilirubin is bound to lysine residue 240 at its high-affinity site on human serum albumin.	Lysine	48-54	albumin	Homo sapiens	102-115
656461-5	1978	This suggests that anhydride leghemoglobin has a conformation with a covalent attachment via propionic acid side chain to lysine-57 and the sixth coordination position of the heme iron occupied by the distal histidine at position 61.	Lysine	122-128	leghemoglobin A	Glycine max	29-42
656461-6	1978	Native leghemoglobin is assumed to exist in a similar type of configuration at low temperature, but with the heme propionate side chain being involved in a salt bridge with lysine-57.	Lysine	173-179	leghemoglobin A	Glycine max	7-20
209452-2	1978	The alpha-lactalbumin was specifically linked to the lysine residue of insulin or to the alpha-amino group of epidermal growth factor.	Lysine	53-59	insulin	Homo sapiens	71-78
678219-8	1978	(5) On the basis of the extent of mammary extraction, methionine, lysine and leucine were first-, second- and third-limiting to the rate of milk protein synthesis.	Lysine	66-72	Weaning weight-maternal milk	Bos taurus	140-144
204634-5	1978	The data are consisten with a specfic covalent interaction of the lysine 13 derivative of cytochrome c with the polypeptide of molecular weight 23,700 (Subunit II) of cytochrome c oxidase.	Lysine	66-72	cytochrome c, somatic	Homo sapiens	90-102
204634-5	1978	The data are consisten with a specfic covalent interaction of the lysine 13 derivative of cytochrome c with the polypeptide of molecular weight 23,700 (Subunit II) of cytochrome c oxidase.	Lysine	66-72	cytochrome c, somatic	Homo sapiens	167-179
24408196-10	1978	Amino acid compositions determined after acid hydrolysis show marked differences between L-1 and L-2, particularly with respect to the amino acids Lys, Phe, Ser, Gly and Leu.	Lysine	147-150	seed linoleate 13S-lipoxygenase-1	Glycine max	89-92
563242-3	1977	In lysine (or other essential amino acid)-deficient medium, the effects of insulin are different.	Lysine	3-9	insulin	Gallus gallus	75-82
603622-3	1977	Previous reports from this laboratory have shown that both Lys-33 and Lys-116 are parts of an antigenic site in native lysozyme.	Lysine	59-62	lysozyme	Homo sapiens	119-127
603622-3	1977	Previous reports from this laboratory have shown that both Lys-33 and Lys-116 are parts of an antigenic site in native lysozyme.	Lysine	70-73	lysozyme	Homo sapiens	119-127
603622-15	1977	The previously reported immunochemical effect observed on nitration of Tyr-20 was due to a deleterious ionic effect exerted by the modified tyrosine residue on the adjacent Lys-96, which is in an entirely different antigenic site of lysozyme.	Lysine	173-176	lysozyme	Homo sapiens	233-241
912759-5	1977	In particular, the relative amounts of the two slightly lysine-rich histones H2A and H2B remaining on the BrUdR chromatin proved to be about 3-fold higher than those remaining on the control chromatin of TdR-treated animals.	Lysine	56-62	histone cluster 1, H2bg	Rattus norvegicus	85-88
199233-0	1977	Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5.	Lysine	50-57	cytochrome c, somatic	Homo sapiens	37-49
199245-0	1977	Use of specific lysine modifications to locate the reaction site of cytochrome c with cytochrome oxidase.	Lysine	16-22	cytochrome c, somatic	Homo sapiens	68-80
199245-1	1977	The reaction of cytochrome c with trifluoromethylphenyl isocyanate was carried out under conditions which led to the modification of a small number of the 19 lysines.	Lysine	158-165	cytochrome c, somatic	Homo sapiens	16-28
199245-3	1977	The only modifications which affected the activity of cytochrome c with cytochrome oxidase (EC 1.9.3.1) were those of lysines immediately surrounding the heme crevice, lysines 13, 27, 72, and 79, and also lysine 8 at the top of the heme crevice.	Lysine	118-125	cytochrome c, somatic	Homo sapiens	54-66
199245-3	1977	The only modifications which affected the activity of cytochrome c with cytochrome oxidase (EC 1.9.3.1) were those of lysines immediately surrounding the heme crevice, lysines 13, 27, 72, and 79, and also lysine 8 at the top of the heme crevice.	Lysine	168-175	cytochrome c, somatic	Homo sapiens	54-66
199245-3	1977	The only modifications which affected the activity of cytochrome c with cytochrome oxidase (EC 1.9.3.1) were those of lysines immediately surrounding the heme crevice, lysines 13, 27, 72, and 79, and also lysine 8 at the top of the heme crevice.	Lysine	118-124	cytochrome c, somatic	Homo sapiens	54-66
921942-1	1977	In human deoxyhemoglobin a salt bridge links the alpha carboxyl of Arg-141 of each alpha chain to the epsilon-amino group of Lys-127 of the opposite alpha chain.	Lysine	125-128	Fc gamma receptor and transporter	Homo sapiens	83-94
921942-1	1977	In human deoxyhemoglobin a salt bridge links the alpha carboxyl of Arg-141 of each alpha chain to the epsilon-amino group of Lys-127 of the opposite alpha chain.	Lysine	125-128	Fc gamma receptor and transporter	Homo sapiens	149-160
19247-2	1977	By difference spectroscopy it is possible to follow the shift with pH of the epsilon-CH2 and delta-CH2 proton resonances of lysine-B29 in insulin.	Lysine	124-130	insulin	Homo sapiens	138-145
893412-5	1977	The NH2-terminal sequence of pre-lysozyme is: (formula: see text) where lysine is the NH2 terminus of lysozyme.	Lysine	72-78	lysozyme	Homo sapiens	33-41
893412-5	1977	The NH2-terminal sequence of pre-lysozyme is: (formula: see text) where lysine is the NH2 terminus of lysozyme.	Lysine	72-78	lysozyme	Homo sapiens	102-110
19247-3	1977	In methylated insulin the dimethyl proton resonances of glycine-A1, phenylalanine-B1 and lysine-B29 can be followed as a function of pH.	Lysine	89-95	insulin	Homo sapiens	14-21
19247-4	1977	In native insulin pKapp values of 6.7 and 8.0 are obtained for phenylalanine-B1 and glycine-A1 (the assignment is tentative) and 11.2 for lysine-B29.	Lysine	138-144	insulin	Homo sapiens	10-17
19247-5	1977	Separate resonances have been observed from the lysine-B29 Nepsilon-(CH3)2 group for the monomeric and dimeric forms of methylated insulin, which indicates a small change in the environment of lysine-B29 on dimerisation.	Lysine	48-54	insulin	Homo sapiens	131-138
19247-5	1977	Separate resonances have been observed from the lysine-B29 Nepsilon-(CH3)2 group for the monomeric and dimeric forms of methylated insulin, which indicates a small change in the environment of lysine-B29 on dimerisation.	Lysine	193-199	insulin	Homo sapiens	131-138
830761-6	1977	Similar C1 binding and C consumption in the presence of CRP were seen upon the interaction of multiple additional polyanions including DNA, ENA, hyaluronic acid, chondroitin sulfate, and dextran sulfate with the polycations protamine sulfate and poly-L-lysine.	Lysine	246-259	C-reactive protein	Homo sapiens	56-59
196686-4	1977	The purified enzyme displays high specificity for the lysine-rich histones (H1, H2b, H2a).	Lysine	54-60	tubulin alpha 4a	Homo sapiens	85-88
18104-0	1977	The role of lysines in Euglena cytochrome c-552.	Lysine	12-19	cytochrome c, somatic	Homo sapiens	31-43
845699-5	1977	Uptake of phenylalanine, methionine and lysine by the mammary gland most closely paralleled their output in milk.	Lysine	40-46	Weaning weight-maternal milk	Bos taurus	108-112
233915-6	1977	(3) originally demonstrated that the immune response to the synthetic terpolymer L-glutamic acid, L-lysine, L-phenylaline (GLphi) is under dominant, H-2-linked Ir gene control (4-7).	Lysine	98-106	histocompatibility-2, MHC	Mus musculus	149-152
615448-2	1977	vasopressin-lysine (intramuscularly) to healthy subjects was followed by a significant decrease in the plasma non-esterified fatty acid level.	Lysine	12-18	arginine vasopressin	Homo sapiens	0-11
869924-11	1977	When tested on synthetic amino acid esters, subcomponent C-1r hydrolysed both lysine and tyrosine ester bonds, but subcomponent C-1r did not hydrolyse any amino acid esters tested nor any protein substrate except subcomponent C1s.	Lysine	78-84	complement C1r	Homo sapiens	57-61
403176-1	1977	Rickettsia prowazeki possesses an active transport system for lysine with a Kt of influx of 1 muM.	Lysine	62-68	latexin	Homo sapiens	94-97
189807-0	1977	Effect of specific trifluoroacetylation of individual cytochrome c lysines on the reaction with cytochrome oxidase.	Lysine	67-74	cytochrome c, somatic	Homo sapiens	54-66
189807-1	1977	We have prepared three different cytochrome c derivatives, each containing a single specifically trifluoroacetylated lysine at residues 13, 55, and 99, respectively.	Lysine	117-123	cytochrome c, somatic	Homo sapiens	33-45
189807-2	1977	The only modification that affected cytochrome c oxidase (EC 1.9.3.1) activity was that of lysine-13 at the top of the heme crevice.	Lysine	91-97	cytochrome c, somatic	Homo sapiens	36-48
189807-3	1977	Trifluoroacetylation of lysine-13 increased the apparent Michaelis constant fivefold compared to that of native cytochrome c, but did not affect the maximum velocity.	Lysine	24-30	cytochrome c, somatic	Homo sapiens	112-124
189807-4	1977	Trifluoroacetylation of lysine-55 at the left side of the cytochrome c molecule did not affect cytochrome oxidase activity in any way, nor did trifluoroacetylation of lysine-99 at the rear of the cytochrome c molecule.	Lysine	24-30	cytochrome c, somatic	Homo sapiens	58-70
189807-5	1977	This indicates that the cytochrome oxidase binding site on cytochrome c involved only the front of the cytochrome c molecule and those lysines immediately surrounding the heme crevice.	Lysine	135-142	cytochrome c, somatic	Homo sapiens	59-71
906929-3	1977	Once lysine-derived aldehydic functions in collagen and elastin are formed, crosslinks occur via aldol and Schiff-base type condensations.	Lysine	5-11	elastin	Gallus gallus	56-63
182207-1	1976	The reaction of cytochrome c with ethyl thioltrifluoroacetate was carried out under conditions which led to the selective trifluoroacetylation of a small number of the 19 lysines.	Lysine	171-178	cytochrome c, somatic	Homo sapiens	16-28
977942-2	1976	Inhibition by CRP of platelet reactivities stimulated by poly-L-lysine, ADP, epinephrine, and collagen.	Lysine	57-70	C-reactive protein	Homo sapiens	14-17
977942-4	1976	In the present experiments, CRP was found also to inhibit the ability of washed human platelets to aggregate in response to poly-L-lysine (PLL); in these experiments, the magnitude of the inhibitory effect was dependent upon the m.w.	Lysine	124-137	C-reactive protein	Homo sapiens	28-31
874581-3	1977	The amount of carbon dioxide gas adsorbed by lysozyme, its hydrolyzates and gelatin hydrolyzates depended upon the lysine content, arginine content and average molecular weight.	Lysine	115-121	lysozyme	Homo sapiens	45-53
1002996-15	1976	The partial NH2-terminal sequence of C5a was determined as NH2-Thr-Leu-Glx-Lys-Ile-Glx-Glx-Ile-Ala- and direct comparison with the known sequence of human C3a shows little homology.	Lysine	75-78	complement C5a receptor 1	Homo sapiens	37-40
182207-4	1976	The trifluoroacetylated lysine 22 derivative was fully active toward both succinate-cytochrome c reductase (EC 1.3.99.1) and cytochrome oxidase (EC 1.9.3.1) white the trifluoroacetylated lysine 25 derivative was fully active toward the reductase, but had a threefold greater Michaelis constant in the  cytochrome oxidase reactin.	Lysine	24-30	cytochrome c, somatic	Homo sapiens	84-96
182207-4	1976	The trifluoroacetylated lysine 22 derivative was fully active toward both succinate-cytochrome c reductase (EC 1.3.99.1) and cytochrome oxidase (EC 1.9.3.1) white the trifluoroacetylated lysine 25 derivative was fully active toward the reductase, but had a threefold greater Michaelis constant in the  cytochrome oxidase reactin.	Lysine	187-193	cytochrome c, somatic	Homo sapiens	84-96
4069-0	1976	The role of the lysines in the alkaline heme-linked ionization of ferric cytochrome c.	Lysine	16-23	cytochrome c, somatic	Homo sapiens	73-85
8077-9	1976	We suggest that this group is the Schiff base lysine of the chromophore binding site of rhodopsin which becomes exposed on photolysis.	Lysine	46-52	rhodopsin	Homo sapiens	88-97
950397-5	1976	Lysine infusion resulted in 16% of the total response in yield of milk protein that was obtained with either the 10 essential amino acids or sodium caseinate while infusion of lysine and methionine together accounted for 43% of the total response.	Lysine	0-6	casein beta	Bos taurus	66-78
950397-6	1976	This suggested that lysine and methionine were first and second limiting, or co-limiting, for secretion of milk protein when rations consisting primarily of corn, corn silage, and alfalfa-grass hay were fed.	Lysine	20-26	casein beta	Bos taurus	107-119
938662-6	1976	By the same method, acetylated lysine and glycine were identified for chicken lysozyme and horse myoglobin, respectively.	Lysine	31-37	myoglobin	Equus caballus	97-106
964925-4	1976	Inhibitors of the lysine-type were not inactivated by 1,2-cyclohexanedione/borate, e.g. the bovine trypsin/kallikrein inhibitor, the trypsin inhibitors from cow colostrum, porcine pancreas, or snail epidermis (isoinhibitor K from Helix pomatia), and the human alpha1-proteinase inhibitor (alpha1-antitrypsin).	Lysine	18-24	serpin family A member 1	Homo sapiens	289-307
1030639-1	1976	The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.	Lysine	86-89	growth hormone 1	Homo sapiens	176-190
2602-2	1976	Acetic acid extracts of embryonic chick aorta pulse-labeled with [14C]lysine contain two radioactive proteins of molecular weights 74,000 and 138,000 which have been identified previously as soluble elastin and the pro-alpha chain of collagen, respectively.	Lysine	70-76	elastin	Gallus gallus	199-206
2602-3	1976	In pulse-chase experiments, the radioactivity incorporated in the soluble elastin during the pulse with [14C]lysine disappeared during a 24-hour chase with [12C]lysine and 89% of that which disappeared was accounted for in the desmosines of alkali-insoluble elastin.	Lysine	109-115	elastin	Gallus gallus	74-81
2602-3	1976	In pulse-chase experiments, the radioactivity incorporated in the soluble elastin during the pulse with [14C]lysine disappeared during a 24-hour chase with [12C]lysine and 89% of that which disappeared was accounted for in the desmosines of alkali-insoluble elastin.	Lysine	161-167	elastin	Gallus gallus	74-81
58941-2	1976	PFC were enumerated on poly-L-lysine coupled red cell monolayers in Microtest-II-plates.	Lysine	23-36	complement factor properdin	Homo sapiens	0-3
1248472-2	1976	In ferritin 3.3 +/- 0.3 lysine residues and 7.1 +/- 0.7 carboxyl groups per subunit can be modified, whilst the corresponding values for apoferritin are 4.4 +/- 0.4 lysine residues and 11.0 +/- 0.4 carboxyl groups per subunit.	Lysine	165-171	ferritin heavy chain	Equus caballus	137-148
1248472-3	1976	Modification of lysine residues which maleic anhydride and carboxyl groups with glycineamide in apoferritin which has been dissociated and denatured in guanidine hydrochloride leads to the introduction of 9.1 +/- 0.5 maleyl groups per subunit and 22.0 +/- 0.9 glycineamide residues per subunit.	Lysine	16-22	ferritin heavy chain	Equus caballus	96-107
1191681-3	1975	The azlactone of p-nitrobenzoyl-valine (Nbz-Val) has been used for modification of xi-amino groups of lysine in haptoglobin type 1-1, in hemoglobin, and in the haptoglobin-hemoglobin complex.	Lysine	102-108	haptoglobin	Homo sapiens	112-123
1191641-5	1975	N-terminal analysis of a trypsin digest of chick tropoelastin showed that tyrosine frequently is found adjacent to lysine residues.	Lysine	115-121	elastin	Gallus gallus	49-61
1191681-3	1975	The azlactone of p-nitrobenzoyl-valine (Nbz-Val) has been used for modification of xi-amino groups of lysine in haptoglobin type 1-1, in hemoglobin, and in the haptoglobin-hemoglobin complex.	Lysine	102-108	haptoglobin	Homo sapiens	160-171
1081103-2	1975	H-2 linked responsiveness to the synthetic polypeptide poly(Tyr,Glu)-poly(DL-Ala)--poly(Lys).	Lysine	88-91	histocompatibility-2, MHC	Mus musculus	0-3
1180968-6	1975	Acta 405, 452-463), which accounted for about one-third of the total antigenic reactivity of native lysozyme, was isolated here with lysine 97 attached to it.	Lysine	133-139	lysozyme	Homo sapiens	100-108
1195561-9	1975	The prolongation was such that even with a DI patient refractory to the action of lysine-vasopressin and relatively resistant to deamino-[8-D-Arg]-vasopressin, water turnover could be reduced from untreated levels of 20 to 30 liters/day to less than 2 liters/day with only a single administration of deamino-6-carba-[8-D-Arg]-vasopressin as nose drops.	Lysine	82-88	arginine vasopressin	Rattus norvegicus	89-100
171264-0	1975	Identification of an essential lysine in porcine heart mitochondrial malate dehydrogenase.	Lysine	31-37	malic enzyme 2	Homo sapiens	69-89
171264-6	1975	Amino acid analysis of the peptide demonstrated the presence of N6-pyridoxyl-L-lysine (Lys(Pyx)), establishing the existence of an essential lysing residue in the active center of malate dehydrogenase.	Lysine	87-90	malic enzyme 2	Homo sapiens	180-200
1180968-14	1975	From these and previous results it was concluded that the antigenic reactive site in this part of the lysozyme molecule incorporates one or both of tryptophans 62 and 63 as well as one or both lysines 96 and 97.	Lysine	193-200	lysozyme	Homo sapiens	102-110
1192687-6	1975	After an immediate and transient antidiuresis, a single intravenous bolus injection of lysine vasopressin given during treatment with chlorpropamide, chlorpropamide with a continuous intravenous infusion of lysine vasopressin, carbamazepine or clofibrate, resulted in increased water diuresis for 12-24 h or longer.	Lysine	87-93	arginine vasopressin	Homo sapiens	94-105
1174563-3	1975	The structural characterization of the variant by globin chain separation, peptide mapping, and amino acid analyses of the abnormal peptides indicated that lysine residue 11 (A9) of alpha-chain was replaced by glutamic acid.	Lysine	156-162	Fc gamma receptor and transporter	Homo sapiens	182-193
1164516-11	1975	Correlation of the extent of decrease in immunochemical reaction with the locations of modification and with the results of conformational analysis, led to the conclusion that lysines 33, 96 and 116 are part of antigenic reactive regions in lysozyme.	Lysine	176-183	lysozyme	Homo sapiens	241-249
1171939-8	1975	A high precentage extraction from arterial plasma by the mammary gland also suggested that methionine and lysine may have been the essential amino acids in most critical supply for milk protein synthesis.	Lysine	106-112	Weaning weight-maternal milk	Bos taurus	181-185
1156590-3	1975	(b) Acetylation of both phosvitin and pronase phosphopeptides completely prevents their phosphorylation indicating that some lysine residues are strictly required for the phosvitin kinase reaction.	Lysine	125-131	casein kinase 2 beta	Rattus norvegicus	24-33
1156590-3	1975	(b) Acetylation of both phosvitin and pronase phosphopeptides completely prevents their phosphorylation indicating that some lysine residues are strictly required for the phosvitin kinase reaction.	Lysine	125-131	casein kinase 2 beta	Rattus norvegicus	171-180
1156590-7	1975	It is proposed therefore that the peptidic unit able to undergo phosphorylation by rat liver cytosol phosvitin kinase consists of one or more phosphorylserine residues having in their close proximity a lysine residue playing a critical role in the mechanism of transphosphorylation.	Lysine	202-208	casein kinase 2 beta	Rattus norvegicus	101-110
240356-0	1975	Is lysine 79 a ligand for iron hexacyanides bound to cytochrome c?	Lysine	3-9	cytochrome c, somatic	Homo sapiens	53-65
809531-3	1975	Cationic homopolymers of poly-L-lysine were found to activate complement (C) via C-reactive protein (CRP) and deplete C3 and C5 as well as early-acting C components.	Lysine	25-38	C-reactive protein	Homo sapiens	81-99
809531-3	1975	Cationic homopolymers of poly-L-lysine were found to activate complement (C) via C-reactive protein (CRP) and deplete C3 and C5 as well as early-acting C components.	Lysine	25-38	C-reactive protein	Homo sapiens	101-104
1171984-7	1975	Thus [3-thienylalanine]-8-lysine-vasopressin has higher oxytocic, avian vasodepressor, and antidiuretic potencies than does 8-lysine-vasopressin, whereas its pressor potency is about the same as or slightly lower than that of 8-lysine-vasopressin.	Lysine	25-32	arginine vasopressin	Rattus norvegicus	33-44
1122639-3	1975	The following average values, related to 1 g creatinine, were found: Lys(Me) 16.2 mumol, Lys(Me2) 31.2 mumol, Lys(Me3) 40.5 mumol.	Lysine	89-92	malic enzyme 2	Homo sapiens	93-96
1112783-5	1975	The evidence presented suggests the formation of a Schiff base between pyridoxal-5-P and a nucleophilic residue, most likely lysine, of malate dehydrogenase during the first phase of inactivation.	Lysine	125-131	malic enzyme 2	Homo sapiens	136-156
1170880-7	1975	Peptide MT-2 was domaleated and sequenced by manual Edman degradations through a single lysine residue.	Lysine	88-94	metallothionein-2	Bos taurus	8-12
1122639-3	1975	The following average values, related to 1 g creatinine, were found: Lys(Me) 16.2 mumol, Lys(Me2) 31.2 mumol, Lys(Me3) 40.5 mumol.	Lysine	89-92	malic enzyme 2	Homo sapiens	93-96
4855467-0	1974	(1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)-8-lysine-vasopressin and (1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)oxytocin, compounds possessing antihormonal properties.	Lysine	61-68	arginine vasopressin	Homo sapiens	69-80
1169252-1	1975	[Lys-22-B] human insulin.	Lysine	1-4	insulin	Homo sapiens	17-24
48419-8	1975	The following amino acids were found in CEA: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, emthionine, isoleucine, leucine, tyrosine, phenylalanine, and cysteine.	Lysine	45-51	CEA cell adhesion molecule 3	Homo sapiens	40-43
4433707-0	1974	Letter: Influence of chiral uncharged Co(III) complexes on the helix-coil transition of poly-L-lysine.	Lysine	88-101	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	38-45
4337249-2	1972	The Forster parameters involved in energy transfer from the donor Trp(9) to the dansyl acceptor attached to the side chain of Lys(21) were determined from measurements with ACTH fragments containing either the donor or the acceptor alone.	Lysine	126-129	proopiomelanocortin	Homo sapiens	173-177
4722032-1	1973	The use of mutants with additional lysine residues in the coat protein.	Lysine	35-41	golgi phosphoprotein 3	Homo sapiens	58-70
4722032-4	1973	Mutant B13a has two new lysine residues in the coat protein, replacing a glutamine at position 9 and an asparagine at position 33, whereas mutant B13b has the single replacement of glutamine by lysine at position 9.	Lysine	24-30	golgi phosphoprotein 3	Homo sapiens	47-59
4722032-6	1973	However, when the isolated coat protein from mutant B13a was treated with methyl picolinimidate, the lysine residue at position 33 did become modified, showing that the loss in reactivity of this residue towards the imidoester in the intact virus is a result of the assembly of the protein subunit into the virus structure.	Lysine	101-107	golgi phosphoprotein 3	Homo sapiens	27-39
4651137-5	1972	The degree of hydroxylation of the lysine moieties was increased by approximately 50% in the alpha1(I)-chain and alpha2-chain of rachitic bone collagen.	Lysine	35-41	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	93-99
5533197-7	1970	The only firmly established aspect of the rhodopsin active site remains the demonstration in our previous work that at the metarhodopsin-II stage the retinyl moiety is linked to an in-amino group of lysine.	Lysine	199-205	rhodopsin	Homo sapiens	42-51
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Lysine	161-167	somatotropin	Oryctolagus cuniculus	5-19
4355304-0	1971	Bradykinin potentiating peptide PCA-Lys-Trp-Ala-Pro.	Lysine	36-39	kininogen 1	Homo sapiens	0-10
4396920-8	1971	When bovine serum albumin is substituted for L-lysine, the same compound results upon acid hydrolysis.	Lysine	45-53	albumin	Homo sapiens	12-25
5280519-3	1971	Attachment through the epsilon-amino group of the lysine residue to a polystyrene resin has been applied to a solid-phase synthesis of lysine-vasopressin.	Lysine	50-56	arginine vasopressin	Rattus norvegicus	142-153
5087618-0	1971	Identification of lysines reactive with pyridoxal 5"-phosphate in glyceraldehyde-3-phosphate dehydrogenase.	Lysine	18-25	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	66-106
5696551-3	1968	The amino-acid substitution was found to be a replacement of the asparagine residue by one of lysine in the 78th position of the 141 of the alpha-chain.	Lysine	94-100	Fc gamma receptor and transporter	Homo sapiens	140-151
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Lysine	105-118	beta-glucuronidase	Bos taurus	174-192
4974308-19	1969	Determination of the amino acid composition revealed a decreased content of lysine, glucosamine, and galactosamine in abnormal fibrinogen.	Lysine	76-82	fibrinogen beta chain	Homo sapiens	127-137
4980717-9	1969	The red colour is probably formed by reaction of the lysine in-amino groups of bovine serum albumin, as it is prevented by treating the protein with formaldehyde, succinic anhydride or O-methylisourea.	Lysine	53-59	albumin	Homo sapiens	86-99
5776519-4	1969	The expression of resistance to p-fluorophenylalanine by fpr-1 can be suppressed by genes controlling a requirement for lysine or arginine.	Lysine	120-126	formyl peptide receptor 1	Homo sapiens	57-62
5704817-5	1968	Degradative studies established that the retinyl moiety in this reduced derivative of rhodopsin was attached to the in-amino group of lysine.	Lysine	134-140	rhodopsin	Homo sapiens	86-95
5880873-0	1965	Amino acid sequence around a reactive lysine in glyceraldehyde 3-phosphate dehydrogenase.	Lysine	38-44	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	48-88
5179829-0	1966	[Intensive studies with vasopressin lysine].	Lysine	36-42	arginine vasopressin	Homo sapiens	24-35
5840401-0	1965	The reversible masking of the lysine residue of alpha-melanocyte-stimulating hormone.	Lysine	30-36	proopiomelanocortin	Homo sapiens	48-84
32820394-11	2021	Furthermore, LINC01436 negatively regulated miR-585-3p expression by enhancing the zeste 2 polycomb repressive complex 2 subunit (EZH2)-induced trimethylation of histone H3 at lysine 27 (H3K27me3) on miR-585-3p promoter.	Lysine	176-182	long intergenic non-protein coding RNA 1436	Homo sapiens	13-22
14196563-0	1964	SPECIFIC ACETYLATION OF A LYSINE RESIDUE DURING THE HYDROLYTIC ACTION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE.	Lysine	26-32	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	73-113
33882423-0	2021	Distal lysine (de)coordination in the algal hemoglobin THB1: A combined computer simulation and experimental study.	Lysine	7-13	uncharacterized protein	Chlamydomonas reinhardtii	55-59
33882423-6	2021	Molecular dynamics simulations and hybrid quantum mechanics/molecular mechanics restrained optimizations were performed to explore the nature of the transition between the decoordinated and lysine-bound states of the ferrous heme in THB1.	Lysine	190-196	uncharacterized protein	Chlamydomonas reinhardtii	233-237
33882423-7	2021	Lys49 and Arg52, which form ionic interactions with the heme propionates in the X-ray structure of lysine-bound THB1, were observed to assist in maintaining Lys53 inside the protein cavity and play a key role in the transition.	Lysine	99-105	uncharacterized protein	Chlamydomonas reinhardtii	112-116
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	transforming growth factor beta 1	Homo sapiens	32-40
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	cadherin 1	Homo sapiens	152-162
32820394-11	2021	Furthermore, LINC01436 negatively regulated miR-585-3p expression by enhancing the zeste 2 polycomb repressive complex 2 subunit (EZH2)-induced trimethylation of histone H3 at lysine 27 (H3K27me3) on miR-585-3p promoter.	Lysine	176-182	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	130-134
34053754-0	2021	Effect of feeding hydrolyzed feather meal and rumen-protected lysine on milk protein and energy utilization in late-lactation Jersey cows.	Lysine	62-68	casein beta	Bos taurus	72-84
34058195-5	2021	Within LRP1 CR-clusters II and IV, we identified multiple sites comprised of adjacent CR-doublets, which provide alternative bivalent binding combinations with specific pairs of lysines on RAP.	Lysine	178-185	LDL receptor related protein 1	Homo sapiens	7-11
34058195-6	2021	Mutational analysis of these lysines within each of isolated RAP D1/D2 and D3 domains having high-affinity to LRP1, and of conserved tryptophans on selected CR-doublets of LRP1, as well as in silico docking of a model LRP1 CR-triplet with RAP indicated a universal role for these residues in interaction of RAP and LRP1.	Lysine	29-36	LDL receptor related protein 1	Homo sapiens	110-114
33459068-4	2021	AREA COVERED: This review includes WIPO-listed patents (from January 2017 to June 2020) reporting PSMA-targeted probes based on the Lys-urea-Glu or Glu-urea-Glu structure.	Lysine	132-135	folate hydrolase 1	Homo sapiens	98-102
33496845-4	2021	Using in vitro RNA splicing analysis, we show that the CLRN2 c.494C > A variant leads to two events: (1) the substitution of a highly conserved threonine (uncharged amino acid) to lysine (charged amino acid) at position 165, p.(Thr165Lys), and (2) aberrant splicing, with the retention of intron 2 resulting in a stop codon after 26 additional amino acids, p.(Gly146Lysfs*26).	Lysine	180-186	clarin 2	Homo sapiens	55-60
33313992-7	2021	Results Several compounds (including anthracyclines) bound with higher affinities than the control drugs (sorafenib and vemurafenib for BRAF and PI-103 and LY-294,002 for PIK3R1).	Lysine	156-158	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	171-177
33892380-5	2021	We solved the "Lys-off" X-ray structure of THB1, represented by the cyanide adduct of the Fe(III) protein, and hypothesized that interactions that differ between the known "Lys-on" structure and the Lys-off structure participate in the control of Lys53 affinity for the heme iron.	Lysine	15-18	uncharacterized protein	Chlamydomonas reinhardtii	43-47
33892380-5	2021	We solved the "Lys-off" X-ray structure of THB1, represented by the cyanide adduct of the Fe(III) protein, and hypothesized that interactions that differ between the known "Lys-on" structure and the Lys-off structure participate in the control of Lys53 affinity for the heme iron.	Lysine	173-176	uncharacterized protein	Chlamydomonas reinhardtii	43-47
33892380-5	2021	We solved the "Lys-off" X-ray structure of THB1, represented by the cyanide adduct of the Fe(III) protein, and hypothesized that interactions that differ between the known "Lys-on" structure and the Lys-off structure participate in the control of Lys53 affinity for the heme iron.	Lysine	173-176	uncharacterized protein	Chlamydomonas reinhardtii	43-47
33892380-7	2021	All THB1 modifications resulted in a weakening of lysine affinity and affected the coupling between Lys53 proton binding and heme redox potential.	Lysine	50-56	uncharacterized protein	Chlamydomonas reinhardtii	4-8
33960375-8	2021	D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine.	Lysine	91-94	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	12-16
33960375-8	2021	D560N/R468K MBD4 bound to T:G mismatched DNA shows that the side chain amine moiety of the Lys stabilizes the flipped-out thymine by a water-mediated phosphate pinching, while the backbone carbonyl oxygen of the Lys engages in hydrogen bonds with N2 of the estranged guanine.	Lysine	212-215	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	12-16
34050364-2	2022	In mammals, cryptic transcription is normally repressed at the level of chromatin, and this process is increased upon perturbation of complexes that increase intragenic histone H3 lysine 4 methylation or decrease intragenic H3 lysine 36 methylation, DNA methylation, or nucleosome occupancy.	Lysine	180-186	cripto, FRL-1, cryptic family 1	Homo sapiens	12-19
34050364-2	2022	In mammals, cryptic transcription is normally repressed at the level of chromatin, and this process is increased upon perturbation of complexes that increase intragenic histone H3 lysine 4 methylation or decrease intragenic H3 lysine 36 methylation, DNA methylation, or nucleosome occupancy.	Lysine	227-233	cripto, FRL-1, cryptic family 1	Homo sapiens	12-19
34047687-5	2022	Increased p66shc expression was also associated with decreased histone H3 lysine 9 methylation.	Lysine	74-80	SHC adaptor protein 1	Rattus norvegicus	10-16
34047687-6	2022	Finally, nicotine increased the expression of Kdm4c, a key histone lysine demethylase, and decreased Suv39h1, a critical histone lysine methyltransferase.	Lysine	67-73	lysine demethylase 4C	Rattus norvegicus	46-51
34039605-3	2021	Here, we show that BRD4 is methylated on chromatin at lysine-99 by the protein lysine methyltransferase SETD6.	Lysine	54-60	bromodomain containing 4	Homo sapiens	19-23
34039605-3	2021	Here, we show that BRD4 is methylated on chromatin at lysine-99 by the protein lysine methyltransferase SETD6.	Lysine	54-60	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	104-109
34039605-3	2021	Here, we show that BRD4 is methylated on chromatin at lysine-99 by the protein lysine methyltransferase SETD6.	Lysine	79-85	bromodomain containing 4	Homo sapiens	19-23
34039605-3	2021	Here, we show that BRD4 is methylated on chromatin at lysine-99 by the protein lysine methyltransferase SETD6.	Lysine	79-85	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	104-109
34020664-0	2021	Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	123-150
34032265-4	2021	WD40 repeat protein 5 (WDR5) interacts with all members of human SET1/MLL methyltransferases, which regulate methylation of the histone 3 lysine 4 (H3K4).	Lysine	138-144	WD repeat domain 5	Homo sapiens	0-21
34032265-4	2021	WD40 repeat protein 5 (WDR5) interacts with all members of human SET1/MLL methyltransferases, which regulate methylation of the histone 3 lysine 4 (H3K4).	Lysine	138-144	WD repeat domain 5	Homo sapiens	23-27
34032265-4	2021	WD40 repeat protein 5 (WDR5) interacts with all members of human SET1/MLL methyltransferases, which regulate methylation of the histone 3 lysine 4 (H3K4).	Lysine	138-144	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	65-69
34022816-10	2021	Finally, the differentially-expressed lysine acetylation sites were assessed and we found that 42 acetylated sites of 38 proteins were upregulated in the H/M risk group compared with the L risk group, while 48 acetylated sites of 44 proteins were downregulated, of which Ki67 K1063Ac and FCHSD2 K24Ac were the two acetylated proteins that were most changed.	Lysine	38-44	FCH and double SH3 domains 2	Homo sapiens	288-294
34020664-2	2021	Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that regulates inflammatory-related gene expression after peripheral nerve injury.	Lysine	21-27	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	45-72
34020664-2	2021	Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that regulates inflammatory-related gene expression after peripheral nerve injury.	Lysine	21-27	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	74-78
33978549-1	2021	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-methylation of histone H3 at Lys 27 (H3K27me3) to facilitate chromatin-remodeling and gene-silencing functions.	Lysine	202-205	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34029268-1	2021	ABSTRACT: Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3).	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	10-37
34029268-1	2021	ABSTRACT: Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3).	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	38-42
34015426-7	2021	Positive correlations were found between AFB1-lysine, AFM1 or AFB1-N7-guanine and GST-P+, beta-catenin+ and cyclin D1+ hepatocytes, while Rb+ cells negatively correlated with those AFB1 exposure biomarkers.	Lysine	46-52	glutathione S-transferase pi 1	Rattus norvegicus	82-87
33999923-0	2021	Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence.	Lysine	55-58	tripartite motif containing 32	Homo sapiens	24-30
33999923-6	2021	We map three lysine residues that regulate PEST mediated cleavage and auto-ubiquitylation activity of TRIM32.	Lysine	13-19	tripartite motif containing 32	Homo sapiens	102-108
33999923-7	2021	Mimicking acetylation of lysine K247 completely inhibits TRIM32 cleavage, while the lysines K50 and K401 are implicated in auto-ubiquitylation activity.	Lysine	25-31	tripartite motif containing 32	Homo sapiens	57-63
33999923-9	2021	These findings uncover that TRIM32 is regulated by post-translational modifications of three lysine residues, and a conserved PEST sequence.	Lysine	93-99	tripartite motif containing 32	Homo sapiens	28-34
33986254-1	2021	The histone methyltransferase EZH2 silences gene expression via H3 lysine 27 trimethylation and has been recognized as an important antitumour therapeutic target.	Lysine	67-73	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
34014281-6	2021	We found the SETD2 alpha-tubulin lysine 40 trimethyl mark occurs on microtubules in the brain and in primary neurons in culture, and that the SETD2 C-terminal SRI domain is required for binding and methylation of alpha-tubulin.	Lysine	33-39	SET domain containing 2	Mus musculus	13-18
33998601-8	2021	PTIP, an essential component of the activating histone H3 lysine 4 trimethylation (H3K4Me3) complex, interacts with DACH1 and is recruited by DACH1 to its promoter-binding sites.	Lysine	58-64	PAX interacting (with transcription-activation domain) protein 1	Mus musculus	0-4
33986343-3	2021	We show that Rab12 interacts with RILP, RILP-L1 and RILP-L2 independently of each other, whereby lysine-71, in mouse Rab12, is critical for Rab12 interactions with RILP-L1 or RILP-L2, but is dispensable for the binding of RILP.	Lysine	97-103	Rab interacting lysosomal protein-like 1	Mus musculus	164-171
33978549-1	2021	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-methylation of histone H3 at Lys 27 (H3K27me3) to facilitate chromatin-remodeling and gene-silencing functions.	Lysine	202-205	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
33978549-6	2021	Screening a panel of methyltransferase inhibitors revealed that three inhibitors; GSK126, UNC1999 and EPZ-5687 are the most potent inhibitors that suppressed EZH2 activity selectively on lysine 27 which resulted in increased apoptosis and inhibition of AKT and ERK protein phosphorylation in THP-1 cells.	Lysine	187-193	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	158-162
33978549-6	2021	Screening a panel of methyltransferase inhibitors revealed that three inhibitors; GSK126, UNC1999 and EPZ-5687 are the most potent inhibitors that suppressed EZH2 activity selectively on lysine 27 which resulted in increased apoptosis and inhibition of AKT and ERK protein phosphorylation in THP-1 cells.	Lysine	187-193	AKT serine/threonine kinase 1	Homo sapiens	253-256
33978549-6	2021	Screening a panel of methyltransferase inhibitors revealed that three inhibitors; GSK126, UNC1999 and EPZ-5687 are the most potent inhibitors that suppressed EZH2 activity selectively on lysine 27 which resulted in increased apoptosis and inhibition of AKT and ERK protein phosphorylation in THP-1 cells.	Lysine	187-193	mitogen-activated protein kinase 1	Homo sapiens	261-264
33966047-1	2021	Role of p53 lysine 120 NEDDylation.	Lysine	12-18	tumor protein p53	Homo sapiens	8-11
33976119-1	2021	HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins.	Lysine	126-132	histone deacetylase 1	Homo sapiens	0-5
33872013-4	2021	CPP revealed that the accessibility of lysine residues for covalent modification in tubulin-beta (TUBB), in succinate dehydrogenase (SHDB), and in amyloid-beta peptide (Abeta) is altered in human postmortem brain samples of patients with neurodegenerative diseases.	Lysine	39-45	amyloid beta precursor protein	Homo sapiens	169-174
33743353-1	2021	SET domain-containing 2 (SETD2), the primary methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3) in mammals, is associated with many hematopoietic diseases when mutated.	Lysine	77-83	SET domain containing 2	Mus musculus	0-23
33743353-1	2021	SET domain-containing 2 (SETD2), the primary methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3) in mammals, is associated with many hematopoietic diseases when mutated.	Lysine	77-83	SET domain containing 2	Mus musculus	25-30
33705755-3	2021	The RNA recognition motif (RRM) of FUS has the canonical alpha-beta folds along with an unusual lysine-rich loop (KK-loop) between alpha1 and beta2.	Lysine	96-102	FUS RNA binding protein	Homo sapiens	35-38
33952316-4	2021	Thus, altered PANK2 activity is expected to induce CoA deficiency as well as low levels of essential metabolic intermediates such as 4"-phosphopantetheine which is a necessary cofactor for critical proteins involved in cytosolic and mitochondrial pathways such as fatty acid biosynthesis, mitochondrial respiratory complex I assembly and lysine and tetrahydrofolate metabolism, among other metabolic processes.	Lysine	338-344	pantothenate kinase 2	Homo sapiens	14-19
33705755-3	2021	The RNA recognition motif (RRM) of FUS has the canonical alpha-beta folds along with an unusual lysine-rich loop (KK-loop) between alpha1 and beta2.	Lysine	96-102	BCL2 related protein A1	Homo sapiens	131-137
33755722-4	2021	At the molecular level, DEK recruits the corepressor NCoR1 to repress acetylation of histone 3 at lysine 27 (H3K27ac) and restricts the chromatin accessibility of HSCs, governing the expression of quiescence-associated genes (e.g., Akt1/2, Ccnb2, and p21).	Lysine	98-104	AKT serine/threonine kinase 1	Homo sapiens	232-238
33939216-9	2021	Further mechanism studies demonstrated that ZNF213 associated with YAP and facilitated YAP K48-linked poly-ubiquitination at several YAP lysine sites (K252, K254, K321 and K497).	Lysine	137-143	zinc finger protein 213	Homo sapiens	44-50
33938164-5	2021	Several histone chaperones actually interact with Cc Lys residues through their acidic regions, which are also involved in heterotypic interactions leading to liquid-liquid phase transitions responsible for the assembly of nuclear condensates, including heterochromatin.	Lysine	53-56	cytochrome c, somatic	Homo sapiens	50-52
33575967-0	2021	Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination.	Lysine	113-119	ring finger protein 20	Homo sapiens	18-40
33674270-7	2021	Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown.	Lysine	74-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130
33674270-7	2021	Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown.	Lysine	74-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	167-173
33674270-7	2021	Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown.	Lysine	74-80	HNF4A antisense RNA 1	Homo sapiens	191-200
33556366-2	2021	An epigenetic writer, EZH2 has a well-defined role in transcriptional repression by depositing trimethyl marks on lysine 27 of histone H3.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
33751994-14	2021	The findings from this study may assist in the design of more target-specific HSP72 covalent inhibitors exploring the surface-exposed lysine residues.	Lysine	134-140	heat shock protein family A (Hsp70) member 1A	Homo sapiens	78-83
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	RUNX family transcription factor 2	Homo sapiens	218-253
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	192-223
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	225-230
33465813-4	2021	This was accompanied by an increased level of histone H3 lysine 9 (H3K9) di-/tri-methylation at lncH19 promoter.	Lysine	57-63	H2B clustered histone 1	Rattus norvegicus	46-53
33723435-4	2021	Dimethylation of lysine 79 of histone H3 (H3K79me2) and the enzymes (DOT1L and KDM2B) that control this modification are enriched in D2-type medium spiny neurons and are shown to be crucial for the expression of ELS-induced stress susceptibility.	Lysine	17-23	lysine (K)-specific demethylase 2B	Mus musculus	79-84
33279625-3	2021	SETDB1 is a histone lysine methyltransferase responsible for the di- and tri-methylation of histone 3 (H3) at lysine (K) 9 in euchromatic regions further promoting gene silencing through heterochromatin formation.	Lysine	20-26	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
33279625-3	2021	SETDB1 is a histone lysine methyltransferase responsible for the di- and tri-methylation of histone 3 (H3) at lysine (K) 9 in euchromatic regions further promoting gene silencing through heterochromatin formation.	Lysine	20-26	H3 clustered histone 14	Homo sapiens	92-105
33279625-3	2021	SETDB1 is a histone lysine methyltransferase responsible for the di- and tri-methylation of histone 3 (H3) at lysine (K) 9 in euchromatic regions further promoting gene silencing through heterochromatin formation.	Lysine	110-116	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
33279625-3	2021	SETDB1 is a histone lysine methyltransferase responsible for the di- and tri-methylation of histone 3 (H3) at lysine (K) 9 in euchromatic regions further promoting gene silencing through heterochromatin formation.	Lysine	110-116	H3 clustered histone 14	Homo sapiens	92-105
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	RUNX family transcription factor 2	Homo sapiens	256-261
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	bone gamma-carboxyglutamate protein	Homo sapiens	280-291
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	bone gamma-carboxyglutamate protein	Homo sapiens	294-297
33996800-6	2021	We further demonstrate that ZNRF1 and Casitas B-lineage lymphoma (CBL), another E3 ubiquitin ligase responsible for EGFR ubiquitination, mediate ubiquitination at distinct lysine residues on EGFR.	Lysine	172-178	zinc and ring finger 1	Homo sapiens	28-33
33996800-6	2021	We further demonstrate that ZNRF1 and Casitas B-lineage lymphoma (CBL), another E3 ubiquitin ligase responsible for EGFR ubiquitination, mediate ubiquitination at distinct lysine residues on EGFR.	Lysine	172-178	epidermal growth factor receptor	Homo sapiens	116-120
33922484-7	2021	Lysine increased milk"s FRAP values and MDA content.	Lysine	0-6	mechanistic target of rapamycin kinase	Homo sapiens	24-28
33989998-4	2021	The present study aims to study the effect of charge-specific modification of basic amino acids (Lys, Arg) and guanidination on the interaction of insulin with its receptor using molecular modelling.	Lysine	97-100	insulin	Homo sapiens	147-154
33989998-5	2021	Our investigation revealed that the guanidination of insulin (Lys-NHC = NHNH2) enhanced and exerted stronger binding of the protein to its receptor through electrostatic interaction than native insulin (Lys-NH3+).	Lysine	62-65	insulin	Homo sapiens	53-60
33989998-5	2021	Our investigation revealed that the guanidination of insulin (Lys-NHC = NHNH2) enhanced and exerted stronger binding of the protein to its receptor through electrostatic interaction than native insulin (Lys-NH3+).	Lysine	62-65	insulin	Homo sapiens	194-201
33989998-5	2021	Our investigation revealed that the guanidination of insulin (Lys-NHC = NHNH2) enhanced and exerted stronger binding of the protein to its receptor through electrostatic interaction than native insulin (Lys-NH3+).	Lysine	203-206	insulin	Homo sapiens	53-60
33989998-5	2021	Our investigation revealed that the guanidination of insulin (Lys-NHC = NHNH2) enhanced and exerted stronger binding of the protein to its receptor through electrostatic interaction than native insulin (Lys-NH3+).	Lysine	203-206	insulin	Homo sapiens	194-201
33854041-10	2021	Taken together, Sirt1 deacetylates p62 at lysine 295 to disturb Keap1-mediated p62 poly-ubiquitination, thus up-regulating p62 expression to promote hepato-carcinogenesis.	Lysine	42-48	kelch like ECH associated protein 1	Homo sapiens	64-69
33883577-2	2021	However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood.	Lysine	44-50	alkB homolog 4, lysine demethylase	Homo sapiens	63-69
33400925-0	2021	Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.	Lysine	37-43	CREB binding protein	Homo sapiens	63-66
33400925-1	2021	The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and KAT3B) maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains.	Lysine	131-137	CREB binding protein	Homo sapiens	21-41
33400925-1	2021	The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and KAT3B) maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains.	Lysine	131-137	CREB binding protein	Homo sapiens	43-46
33400925-1	2021	The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and KAT3B) maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains.	Lysine	131-137	CREB binding protein	Homo sapiens	72-77
33864616-2	2021	NSD family proteins encoding histone H3 lysine 36 (H3K36) methyltransferases are conserved in many species, and Drosophila has a single NSD homolog gene, NSD.	Lysine	40-46	solute carrier family 17 member 5	Homo sapiens	0-3
33864616-2	2021	NSD family proteins encoding histone H3 lysine 36 (H3K36) methyltransferases are conserved in many species, and Drosophila has a single NSD homolog gene, NSD.	Lysine	40-46	solute carrier family 17 member 5	Homo sapiens	136-139
33864616-2	2021	NSD family proteins encoding histone H3 lysine 36 (H3K36) methyltransferases are conserved in many species, and Drosophila has a single NSD homolog gene, NSD.	Lysine	40-46	solute carrier family 17 member 5	Homo sapiens	136-139
33866370-5	2021	In this study, we confirmed the lysine-590 residue in the C-terminal cytosolic region of BOR1 as the direct ubiquitination site and showed that BOR1 undergoes K63-linked polyubiquitination.	Lysine	32-38	HCO3- transporter family	Arabidopsis thaliana	89-93
33511756-2	2021	SETDB1 contains a unique tandem tudor domain (TTD) that recognizes histone H3 sequences containing both methylated and acetylated lysines.	Lysine	130-137	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
33916826-0	2021	Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis.	Lysine	0-6	cytochrome c, somatic	Homo sapiens	25-37
33582133-6	2021	We show that both the number and the position of phosphorylated threonines/serines or acetylated lysines can serve as a molecular on/off switch for phase separation in the well-studied disordered regions of FUS and DDX3X, respectively.	Lysine	97-104	FUS RNA binding protein	Homo sapiens	207-210
33783213-2	2021	In this study, three 18F-labeled PSMA tracers with a more lipophilic quinoline functional spacer were designed, synthesized, and evaluated based on the Glu-Ureido-Lys binding motif.	Lysine	163-166	folate hydrolase 1	Homo sapiens	33-37
33827814-3	2021	Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.	Lysine	113-119	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	51-78
33827814-3	2021	Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.	Lysine	113-119	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	80-84
33916826-5	2021	Our data show that Cytc is acetylated on lysine 53 in both androgen hormone-resistant and -sensitive human prostate cancer xenografts.	Lysine	41-47	cytochrome c, somatic	Homo sapiens	19-23
32164484-2	2021	The objective of this study was to determine the relationship between the sequential ubiquitination of lysine residues K284 to K214 in AKT and R-HSPA5 (the arginylated form of HSPA5), which contribute to the autophagic/lysosomal degradation of AKT when impaired proteasomal activity induces cellular stress.	Lysine	103-109	thymoma viral proto-oncogene 1	Mus musculus	135-138
32164484-2	2021	The objective of this study was to determine the relationship between the sequential ubiquitination of lysine residues K284 to K214 in AKT and R-HSPA5 (the arginylated form of HSPA5), which contribute to the autophagic/lysosomal degradation of AKT when impaired proteasomal activity induces cellular stress.	Lysine	103-109	heat shock protein 5	Mus musculus	145-150
32164484-2	2021	The objective of this study was to determine the relationship between the sequential ubiquitination of lysine residues K284 to K214 in AKT and R-HSPA5 (the arginylated form of HSPA5), which contribute to the autophagic/lysosomal degradation of AKT when impaired proteasomal activity induces cellular stress.	Lysine	103-109	thymoma viral proto-oncogene 1	Mus musculus	244-247
33795413-2	2021	Here, we identify a conserved mammalian lysine 79 of histone H3 (H3K79) methyltransferase, disruptor of telomeric silencing -1 like (DOT1L), as a new epigenetic regulator that controls thermogenic adipocyte differentiation and function.	Lysine	40-46	DOT1 like histone lysine methyltransferase	Homo sapiens	133-138
33636429-1	2021	Disruptor of telomeric silencing-1 like (DOT1L) is a histone H3 methyltransferase which specifically catalyzes the methylation of histone H3 lysine-79 residue.	Lysine	141-147	DOT1 like histone lysine methyltransferase	Homo sapiens	0-39
33636429-1	2021	Disruptor of telomeric silencing-1 like (DOT1L) is a histone H3 methyltransferase which specifically catalyzes the methylation of histone H3 lysine-79 residue.	Lysine	141-147	DOT1 like histone lysine methyltransferase	Homo sapiens	41-46
33615636-4	2021	The canonical role of EZH2 is gene silencing through catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3) in a PRC2-dependent manner.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
33685627-3	2021	Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22).	Lysine	53-59	ring finger protein 20	Homo sapiens	111-116
33685627-3	2021	Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22).	Lysine	53-59	ring finger protein 40	Homo sapiens	117-122
32737855-4	2021	CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase (HAT) domain, leading to acetylation of Slug at lysines 166 and 211.	Lysine	154-161	CREB binding protein	Homo sapiens	0-3
33734501-5	2021	Through the set of systematic mass spectrometry analyses conducted on SMURF2-modified cells, we identified on PARP1 18 lysine residues (out of 126 present in PARP1) as sites which ubiquitination was considerably affected by SMURF2.	Lysine	119-125	poly(ADP-ribose) polymerase 1	Homo sapiens	110-115
33368310-2	2021	Histone three lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a critical epigenetic modifier and plays an important role in regulating osteogenic differentiation.	Lysine	14-20	lysine demethylase 6A	Homo sapiens	67-72
33540251-2	2021	Epigenetic regulation of peroxisome proliferator-activated receptor gamma (PPARgamma), such as DNA methylation and trimethylation of lysine 4 of H3 (H3K4me3), may provide a potential mechanism for how fetal growth and development are impacted by chlorpyrifos exposure.	Lysine	133-139	peroxisome proliferator activated receptor gamma	Homo sapiens	25-73
33540251-2	2021	Epigenetic regulation of peroxisome proliferator-activated receptor gamma (PPARgamma), such as DNA methylation and trimethylation of lysine 4 of H3 (H3K4me3), may provide a potential mechanism for how fetal growth and development are impacted by chlorpyrifos exposure.	Lysine	133-139	peroxisome proliferator activated receptor gamma	Homo sapiens	75-84
33742125-2	2021	NSD2, a histone methyltransferase catalyzing di-methylation of histone H3 at lysine 36, has been proved a critical molecule in proliferation, metastasis, and tumorigenesis.	Lysine	77-83	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
33742125-7	2021	In addition, mass spectrometry and site-directed mutagenesis assays revealed that NSD2 methylated STAT3 at lysine 163 (K163).	Lysine	107-113	nuclear receptor binding SET domain protein 2	Homo sapiens	82-86
33742125-7	2021	In addition, mass spectrometry and site-directed mutagenesis assays revealed that NSD2 methylated STAT3 at lysine 163 (K163).	Lysine	107-113	signal transducer and activator of transcription 3	Homo sapiens	98-103
32737855-6	2021	Notably, Slug acetylation, mediated by CBP at lysines 166 and 211, doubles its half-life and increases its stability.	Lysine	46-53	CREB binding protein	Homo sapiens	39-42
33851105-5	2021	Mechanistically, mass spectrometry data revealed that HGC stimulates acetylation modification at lysine 28 of NDUFV1.	Lysine	97-103	NADH:ubiquinone oxidoreductase core subunit V1	Mus musculus	110-116
33723063-3	2021	Here, we show that, upon DSB induction, the key resection factor CtIP is modified by the ubiquitin-like protein SUMO at lysine 578 in a PIAS4-dependent manner.	Lysine	120-126	RB binding protein 8, endonuclease	Homo sapiens	65-69
33419772-4	2021	Loss of HDAC5 increased histone H3 lysine 27 acetylation (H3K27-ac) and circumvented RB-mediated repression of cell cycle-related pro-oncogenic genes.	Lysine	35-41	histone deacetylase 5	Homo sapiens	8-13
33712741-4	2021	In addition, we found that OGD-induced nuclear translocation of PTEN is dependent on PTEN mono-ubiquitination at the lysine 13 residue (K13) that is mediated by neural precursor cell expressed developmentally downregulated protein 4-1 (NEDD4-1).	Lysine	117-123	keratin 13	Rattus norvegicus	136-139
33723214-9	2021	The phosphorylation of AKT (T308/S473) was activated due to the blocked ubiquitination site of Lys in 0-52aa peptide of circ-LNLM.	Lysine	95-98	AKT serine/threonine kinase 1	Homo sapiens	23-26
33676077-3	2021	Here, we show that Npac, a "reader" of histone H3 lysine 36 trimethylation (H3K36me3), is required to maintain mouse ESC (mESC) pluripotency since knockdown of Npac causes mESC differentiation.	Lysine	50-56	glyoxylate reductase 1 homolog (Arabidopsis)	Mus musculus	19-23
33796551-4	2021	Mechanistically, ASXL1 forms a complex with BAP1 for the erasure of mono-ubiquitylation at lysine 119 on Histone H2A (H2AK119ub1), a well-known histone mark associated with transcription repression.	Lysine	91-97	BRCA1 associated protein 1	Homo sapiens	44-48
33658352-8	2021	Treatment with a peptide consisting of amino acids 403 to 416 of IL-17RB blocks MLK4 binding, tyrosine-477 phosphorylation, and lysine-470 ubiquitination in vivo, thereby inhibiting tumorigenesis and metastasis and prolonging the life span of mice bearing pancreatic tumors.	Lysine	128-134	interleukin 17 receptor B	Mus musculus	65-72
33675746-7	2021	The Leu50 in ARID4A is Glu50 in ARID4B and the latter forms salt bridges with two lysine residues at the DNA-binding surface.	Lysine	82-88	AT-rich interaction domain 4A	Homo sapiens	13-19
33675746-7	2021	The Leu50 in ARID4A is Glu50 in ARID4B and the latter forms salt bridges with two lysine residues at the DNA-binding surface.	Lysine	82-88	AT-rich interaction domain 4B	Homo sapiens	32-38
32970364-4	2021	Ubiquitin ligases RGLG1 and RGLG2 ubiquitinated MAPKKK18 at lysine residue K32 and K154, and promoted its degradation.	Lysine	60-66	mitogen-activated protein kinase kinase kinase 18	Arabidopsis thaliana	48-56
33522413-8	2021	Reduction of PAX2 or PTIP protein levels by short-interfering RNA prevented histone lysine methylation and expression of Avpr2.	Lysine	84-90	paired box 2	Mus musculus	13-17
33522413-8	2021	Reduction of PAX2 or PTIP protein levels by short-interfering RNA prevented histone lysine methylation and expression of Avpr2.	Lysine	84-90	PAX interacting (with transcription-activation domain) protein 1	Mus musculus	21-25
33522413-9	2021	ChIP using mouse or human kidney determined that PAX2 is highly enriched in the AVPR2 promoter alongside PTIP and HMT proteins, leading to high levels of histone H3 lysine trimethylation within the promoter and throughout the gene.	Lysine	165-171	arginine vasopressin receptor 2	Homo sapiens	80-85
32535965-0	2021	Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells.	Lysine	59-65	sirtuin 6	Mus musculus	0-5
32535965-0	2021	Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells.	Lysine	59-65	SMAD family member 2	Mus musculus	72-77
32535965-11	2021	Mass spectrometry revealed that Sirt6 deacetylated conserved lysine 54 on Smad2.	Lysine	61-67	SMAD family member 2	Mus musculus	74-79
33580754-5	2021	The high expression of Lhx8 in the early dental mesenchyme maintained the cell fate in an undifferentiated status by interacting with Suv39h1, a histone-lysine N-methyltransferase constitutively expressed in the dental mesenchyme.	Lysine	153-159	SUV39H1 histone lysine methyltransferase	Homo sapiens	134-141
33585151-0	2021	Site-directed mutagenesis in the P-domain of calreticulin transacylase identifies Lys-207 as the active site residue.	Lysine	82-85	calreticulin	Homo sapiens	45-57
33585151-1	2021	In silico-docking studies from previous work have suggested that Lys-206 and lys-207 of calreticulin (CR) play a pivotal key role in its well-established transacetylation activity.	Lysine	65-68	calreticulin	Homo sapiens	88-100
33585151-1	2021	In silico-docking studies from previous work have suggested that Lys-206 and lys-207 of calreticulin (CR) play a pivotal key role in its well-established transacetylation activity.	Lysine	77-80	calreticulin	Homo sapiens	88-100
32999468-2	2021	TNF-TNFR1 triggered signaling complex formation, subsequent NF-kappaB and MAPK activation and induction of cell death involve RIPK1 ubiquitination at several lysine residues including Lys376 and Lys115.	Lysine	158-164	tumor necrosis factor	Mus musculus	0-3
32999468-2	2021	TNF-TNFR1 triggered signaling complex formation, subsequent NF-kappaB and MAPK activation and induction of cell death involve RIPK1 ubiquitination at several lysine residues including Lys376 and Lys115.	Lysine	158-164	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	4-9
32999468-2	2021	TNF-TNFR1 triggered signaling complex formation, subsequent NF-kappaB and MAPK activation and induction of cell death involve RIPK1 ubiquitination at several lysine residues including Lys376 and Lys115.	Lysine	158-164	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	126-131
32700783-3	2021	Strikingly, we found that increased di-, and tri-methylation of histone H3 lysine 9 (H3K9me2 and H3K9me3) expression were associated with upregulation of methyltransferase G9a and downregulation of endothelial nitric oxide synthase and CuZn-SOD expression in preeclamptic HUVECs.	Lysine	75-81	nitric oxide synthase 3	Homo sapiens	198-231
33455768-14	2021	Catabolism of Lys and Met only increased with MKH alone, resulting in decreased efficiency for milk protein, which demonstrated that Ile and Leu infusion can spare Lys and Met for milk protein synthesis.	Lysine	14-17	casein beta	Bos taurus	95-107
33455768-14	2021	Catabolism of Lys and Met only increased with MKH alone, resulting in decreased efficiency for milk protein, which demonstrated that Ile and Leu infusion can spare Lys and Met for milk protein synthesis.	Lysine	14-17	casein beta	Bos taurus	180-192
33455768-14	2021	Catabolism of Lys and Met only increased with MKH alone, resulting in decreased efficiency for milk protein, which demonstrated that Ile and Leu infusion can spare Lys and Met for milk protein synthesis.	Lysine	164-167	casein beta	Bos taurus	95-107
32546566-2	2021	SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks.	Lysine	17-23	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	0-6
33508542-10	2021	Moreover, clozapine increased the acetylation of histone H3 at lysine 27 residues (H3K27) in MIF promoter.	Lysine	63-69	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	93-96
33649596-3	2021	Here, we show in Arabidopsis thaliana that genes with convergent orientation of transcription are major sources of antisense transcripts and that these genes transcribed on both strands are regulated by a putative Lysine-Specific Demethylase 1 family histone demethylase, FLOWERING LOCUS D (FLD)7,8.	Lysine	214-220	protein FLOWERING locus D-like protein	Arabidopsis thaliana	272-289
33505026-8	2021	METTL3 also interacts physically with the histone 3 lysine 9 (H3K9) tri-methyltransferase SETDB1 and its cofactor TRIM28, and is important for their localization to IAPs.	Lysine	52-58	SET domain, bifurcated 1	Mus musculus	90-96
33649596-3	2021	Here, we show in Arabidopsis thaliana that genes with convergent orientation of transcription are major sources of antisense transcripts and that these genes transcribed on both strands are regulated by a putative Lysine-Specific Demethylase 1 family histone demethylase, FLOWERING LOCUS D (FLD)7,8.	Lysine	214-220	protein FLOWERING locus D-like protein	Arabidopsis thaliana	291-294
33637585-1	2021	Introduction: 68Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA) targeting tracer used for positron emission tomography/computed tomography (PET/CT) imaging.	Lysine	33-36	folate hydrolase 1	Homo sapiens	55-89
33533496-1	2021	In multicellular organisms, Polycomb Repressive Complex2 (PRC2) is known to deposit tri-methylation of lysine 27 of histone H3 (H3K27me3) to establish and maintain gene silencing, critical for developmentally regulated processes.	Lysine	103-109	proteasome core particle subunit alpha 1	Saccharomyces cerevisiae S288C	58-62
33658391-2	2021	The trimethylation of lysine 36 on histone 3 (H3K36me3) catalyzed by SETD2 and the modification of N6-methyladenine (m6A) mRNA mediated by METTL14 play important roles in a variety of normal and pathological biological processes.	Lysine	22-28	SET domain containing 2	Mus musculus	69-74
33658391-2	2021	The trimethylation of lysine 36 on histone 3 (H3K36me3) catalyzed by SETD2 and the modification of N6-methyladenine (m6A) mRNA mediated by METTL14 play important roles in a variety of normal and pathological biological processes.	Lysine	22-28	methyltransferase like 14	Mus musculus	139-146
33639734-2	2021	In the present work, extensive atomistic molecular dynamics simulations were performed to investigate the hydration properties of aqueous solutions of concentrated arginine, histidine, and lysine and their comparative efficiency on regulating the conformational stability of the insulin monomer.	Lysine	189-195	insulin	Homo sapiens	279-286
33639734-5	2021	We observed that while the salt bridges formed by the lysine as an additive contributed more toward the direct interactions with insulin, the cation-pi was more prominent for the insulin-arginine interactions.	Lysine	54-60	insulin	Homo sapiens	129-136
33639734-6	2021	Importantly, it was observed that the preferentially more excluded arginine, compared to histidine and lysine from the insulin surface, enriches the hydration layer of the protein.	Lysine	103-109	insulin	Homo sapiens	119-126
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Lysine	362-368	insulin	Homo sapiens	62-69
33637585-1	2021	Introduction: 68Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA) targeting tracer used for positron emission tomography/computed tomography (PET/CT) imaging.	Lysine	33-36	folate hydrolase 1	Homo sapiens	91-95
33688506-7	2021	Results: Bioinformatic analysis revealed the differential expression of the histone demethylase JMJD2B/KDM4B, a well-known epigenetic modulator that leads to the demethylation of different lysine residues on histones, in IL-13-treated lung fibroblasts.	Lysine	189-195	lysine demethylase 4B	Homo sapiens	96-102
33688506-7	2021	Results: Bioinformatic analysis revealed the differential expression of the histone demethylase JMJD2B/KDM4B, a well-known epigenetic modulator that leads to the demethylation of different lysine residues on histones, in IL-13-treated lung fibroblasts.	Lysine	189-195	interleukin 13	Homo sapiens	221-226
33633164-1	2021	UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers.	Lysine	37-43	lysine demethylase 6A	Homo sapiens	0-3
33633164-1	2021	UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers.	Lysine	37-43	lysine demethylase 6A	Homo sapiens	4-9
33688506-7	2021	Results: Bioinformatic analysis revealed the differential expression of the histone demethylase JMJD2B/KDM4B, a well-known epigenetic modulator that leads to the demethylation of different lysine residues on histones, in IL-13-treated lung fibroblasts.	Lysine	189-195	lysine demethylase 4B	Homo sapiens	103-108
33681613-0	2021	Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer"s and Parkinson"s Disease.	Lysine	101-107	poly(ADP-ribose) polymerase 1	Homo sapiens	38-43
33681613-10	2021	Moreover, 15 putative lysine sites have been found in the crosstalk and K148, K249, K528, K637, K700, and K796 of PARP1 are crosstalk hotspots.	Lysine	22-28	poly(ADP-ribose) polymerase 1	Homo sapiens	114-119
33596982-3	2021	Lysine-specific demethylase 5A (KDM5A, also known as JARID1A or RBP2) is a KDM5 Jumonji histone demethylase subfamily member that erases di- and tri-methyl groups from lysine 4 of histone H3.	Lysine	168-174	retinol binding protein 2	Homo sapiens	64-68
33610546-0	2021	A repeated triple lysine motif anchors complexes containing bone sialoprotein and the type XI collagen A1 chain involved in bone mineralization.	Lysine	18-24	integrin binding sialoprotein	Homo sapiens	60-77
33679454-1	2021	Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme that catalyzes the addition of methyl groups to histone H3 at lysine 27, leading to gene silencing.	Lysine	48-54	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
33679454-1	2021	Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme that catalyzes the addition of methyl groups to histone H3 at lysine 27, leading to gene silencing.	Lysine	48-54	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
33738331-4	2021	Since lysine-specific demethylase 1A (LSD1/KDM1A) normally removes the H3K4 methyl marks added by KMT2D, we hypothesized that inhibition of KDM1A demethylase activity may ameliorate molecular and phenotypic defects stemming from KMT2D loss.	Lysine	6-12	lysine (K)-specific demethylase 1A	Mus musculus	38-42
33738331-4	2021	Since lysine-specific demethylase 1A (LSD1/KDM1A) normally removes the H3K4 methyl marks added by KMT2D, we hypothesized that inhibition of KDM1A demethylase activity may ameliorate molecular and phenotypic defects stemming from KMT2D loss.	Lysine	6-12	lysine (K)-specific demethylase 1A	Mus musculus	43-48
33586321-6	2021	We found that although the recombinantly produced enzymes have similar kinetic properties, AtDHDPS1 is 10-fold more sensitive to lysine.	Lysine	129-135	dihydrodipicolinate synthase 1	Arabidopsis thaliana	91-99
33596421-3	2021	In addition, PI3K/AKT inhibitors induce drug resistance by selectively augmenting histone H3 lysine 27 acetylation (H3K27ac) and binding of CBP/p300 and BRD4 proteins at a subset of growth factor and receptor (GF/R) gene loci.	Lysine	93-99	AKT serine/threonine kinase 1	Homo sapiens	18-21
33586321-9	2021	Microscale thermophoresis studies supported our hypothesis, with AtDHDPS1 having a ~6-fold tighter lysine dissociation constant compared to AtDHDPS2, which agrees with the lower half minimal inhibitory concentration for lysine observed.	Lysine	99-105	dihydrodipicolinate synthase 1	Arabidopsis thaliana	65-73
33586321-9	2021	Microscale thermophoresis studies supported our hypothesis, with AtDHDPS1 having a ~6-fold tighter lysine dissociation constant compared to AtDHDPS2, which agrees with the lower half minimal inhibitory concentration for lysine observed.	Lysine	220-226	dihydrodipicolinate synthase 1	Arabidopsis thaliana	65-73
33522809-1	2021	Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date.	Lysine	26-32	nuclear receptor binding SET domain protein 2	Homo sapiens	51-55
33589584-4	2021	Overexpressed histone methyltransferase NSD2 in patients bearing a t(4;14) translocation or in BTZ-resistant MM cells coordinates elevated SRC-3 by enhancing its liquid-liquid phase separation to supranormally modify histone H3 lysine 36 dimethylation (H3K36me2) modifications on promoters of anti-apoptotic genes.	Lysine	228-234	nuclear receptor binding SET domain protein 2	Homo sapiens	40-44
33441400-3	2021	During development, Sox11 is required for RGC differentiation from retinal progenitor cells (RPCs), and we found that mutation of a single residue to prevent sumoylation at lysine 91 (K91) increased nuclear localization and RGC differentiation in vitro Here we explored whether this Sox11 manipulation similarly has stronger effects on RGC survival and optic nerve regeneration.	Lysine	173-179	SRY (sex determining region Y)-box 11	Mus musculus	20-25
33441400-3	2021	During development, Sox11 is required for RGC differentiation from retinal progenitor cells (RPCs), and we found that mutation of a single residue to prevent sumoylation at lysine 91 (K91) increased nuclear localization and RGC differentiation in vitro Here we explored whether this Sox11 manipulation similarly has stronger effects on RGC survival and optic nerve regeneration.	Lysine	173-179	SRY (sex determining region Y)-box 11	Mus musculus	283-288
33557746-0	2021	Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy.	Lysine	36-42	CD79a molecule	Homo sapiens	71-74
33535487-5	2021	Here, a hybrid lysine-specific histone demethylase inhibitor, MC3324, displaying selective estrogen receptor down-regulator-like activities in BC, was used to highlight the interplay between epigenetic and ERalpha signaling.	Lysine	15-21	estrogen receptor 1	Homo sapiens	91-108
33546767-7	2021	We found that inhibition of NAMPT or SIRT2 in iPS cells induces p53 protein by promoting its lysine acetylation.	Lysine	93-99	tumor protein p53	Homo sapiens	64-67
33613612-3	2021	The repressive epigenetic mark trimethylation of lysine 27 on histone H3 proteins (H3K27me3) is a critical contributor to the epigenetic silencing of FLC.	Lysine	49-55	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	150-153
33471541-5	2021	Inspired by the post-translational modification of complex biomolecules by enzymatic systems, we then applied this supramolecular reaction to the site-selective labeling of a single lysine residue in an 11-amino acid peptide chain and human insulin.	Lysine	182-188	insulin	Homo sapiens	241-248
33539881-2	2021	The central ATPase of BAF is either BRM or BRG1, both of which contain a C-terminal bromodomain, known to associate with acetylated lysines.	Lysine	132-139	BAF nuclear assembly factor 1	Homo sapiens	22-25
33249170-2	2021	Here, a recombinant peptide identified in human apolipoprotein B sequence, named r(P)ApoBL and endowed with antimicrobial activity, was studied as a possible acyl acceptor substrate of mTG with at least one of the six Lys residues present in its sequence.	Lysine	218-221	apolipoprotein B	Homo sapiens	48-64
32895487-8	2021	We identified the lysine 133 (K133) residue in Oct4 as a ubiquitination site responsible for the Kap1-Itch-dependent regulation of Oct4 stability.	Lysine	18-24	itchy, E3 ubiquitin protein ligase	Mus musculus	102-106
33327751-8	2021	Mechanistically, SIRT3 deacetylates and activates PDHA1 (pyruvate dehydrogenase E1 alpha) at lysine 83, and the loss of SIRT3 leads to PDH activity decrease and lactate accumulation.	Lysine	93-99	pyruvate dehydrogenase E1 alpha 1	Mus musculus	50-55
32343606-10	2021	Mechanistically, the authors demonstrated that silence of DEPDC1 decreased protein expression of SUZ12 and led to a remarkable reduction of trimethylation on lysine 27 residue of histone H3 (H3K27Me3).	Lysine	158-164	DEP domain containing 1	Homo sapiens	58-64
33115801-2	2021	Emerging data have demonstrated histone lysine (K) methylation by methyltransferase SETDB1 as a common denominator of gene regulation in several cancer types.	Lysine	40-46	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	84-90
33535487-5	2021	Here, a hybrid lysine-specific histone demethylase inhibitor, MC3324, displaying selective estrogen receptor down-regulator-like activities in BC, was used to highlight the interplay between epigenetic and ERalpha signaling.	Lysine	15-21	estrogen receptor 1	Homo sapiens	206-213
32671696-5	2021	Correspondingly, histone H3 lysine 9 (H3K9) mono- and dimethylation (marked by H3K9me1 and H3K9me2, respectively), which were regulated by G9a activity, also evidently decreased during aging.	Lysine	28-34	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	139-142
33323973-4	2021	Then, we identified its upstream regulator UBE2T which promotes GC progression via hyperactivating the Wnt/beta-catenin signaling pathway through the ubiquitination and degradation of RACK1 at the lysine K172, K225, and K257 residues independent of an E3 ligase.	Lysine	197-203	ubiquitin conjugating enzyme E2 T	Homo sapiens	43-48
33420361-6	2021	Furthermore, we found that CREB could recruit MMSET, leading to the stabilization of HIF-1alpha protein and the increased dimethylation of histone H3 at lysine 36 on the DKK1 promoter.	Lysine	153-159	nuclear receptor binding SET domain protein 2	Homo sapiens	46-51
33345292-0	2021	Correction to: Fewer Exposed Lysine Residues May Explain Relative Resistance of Chicken Serum Albumin to In Vitro Protein Glycation in Comparison to Bovine Serum Albumin.	Lysine	29-35	albumin	Homo sapiens	94-101
33345292-0	2021	Correction to: Fewer Exposed Lysine Residues May Explain Relative Resistance of Chicken Serum Albumin to In Vitro Protein Glycation in Comparison to Bovine Serum Albumin.	Lysine	29-35	albumin	Homo sapiens	88-101
33513265-6	2021	Our further studies identified Lys313 as a major ubiquitin acceptor lysine of IRF3 induced by MID1.	Lysine	68-74	midline 1	Homo sapiens	94-98
33478492-1	2021	BACKGROUND: Mutations in lysyl-tRNA synthetase (KARS1), an enzyme that charges tRNA with the amino acid lysine in both the cytoplasm and mitochondria, have been associated thus far with autosomal recessive Charcot-Marie-Tooth type CMTRIB, hearing loss type DFNB89, and mitochondrial encephalohepatopathy (MEH) featuring neurodevelopmental disorders with microcephaly, white matter changes, and cardiac and hepatic failure in less than 30 patients.	Lysine	104-110	lysyl-tRNA synthetase 1	Homo sapiens	25-46
33478492-1	2021	BACKGROUND: Mutations in lysyl-tRNA synthetase (KARS1), an enzyme that charges tRNA with the amino acid lysine in both the cytoplasm and mitochondria, have been associated thus far with autosomal recessive Charcot-Marie-Tooth type CMTRIB, hearing loss type DFNB89, and mitochondrial encephalohepatopathy (MEH) featuring neurodevelopmental disorders with microcephaly, white matter changes, and cardiac and hepatic failure in less than 30 patients.	Lysine	104-110	lysyl-tRNA synthetase 1	Homo sapiens	48-53
33498219-3	2021	WNK4 (with-no-lysine 4) regulates the NCC/NKCC2 through SAPK (Ste20-related proline-alanine-rich kinase)/OSR1 (oxidative stress responsive).	Lysine	14-20	solute carrier family 12, member 1	Mus musculus	42-47
33450879-0	2021	Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells.	Lysine	0-6	AKT serine/threonine kinase 1	Homo sapiens	27-30
33469000-1	2021	WHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription.	Lysine	65-71	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
32842150-8	2021	Lysine-dependent, platelet-derived plasminogen retention on thrombin and convulxin activated human platelets was confirmed by flow cytometry.	Lysine	0-6	coagulation factor II, thrombin	Homo sapiens	60-68
33466626-7	2021	FN3K is a unique protein that mediates deglycation by phosphorylating basic amino acids lysine and arginine in various proteins such as Nrf2.	Lysine	88-94	fructosamine 3 kinase	Homo sapiens	0-4
33466626-7	2021	FN3K is a unique protein that mediates deglycation by phosphorylating basic amino acids lysine and arginine in various proteins such as Nrf2.	Lysine	88-94	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
33614242-8	2021	Furthermore, the expression of miR-1224 was inhibited by CREB through EZH2-mediated histone 3 lysine 27 (H3K27me3) on miR-1224 promoter, thus forming a positive feedback circuit.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	70-74
33333446-5	2021	PEGylation yields ranged from 31% +- 2% for CAT-PEG40 to 59% +- 4% for CAT-PEG20 and were strongly affected by the reaction pH owing to the protonation/deprotonation state of primary amines of lysine and N-terminal residues.	Lysine	193-199	catalase	Homo sapiens	44-47
33467728-4	2021	Overall, this work highlights that KAT8 has a broader substrate scope beyond natural lysine, and contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase (KAT) family.	Lysine	85-91	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	35-38
33467728-4	2021	Overall, this work highlights that KAT8 has a broader substrate scope beyond natural lysine, and contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase (KAT) family.	Lysine	194-200	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	35-38
33523893-4	2021	Here, we found that TBC1D3 interacts with G9a, a euchromatic histone lysine N-methyltransferase, which mediates dimethylation of histone 3 in lysine 9 (H3K9me2), a suppressive mark for gene expression.	Lysine	69-75	TBC1 domain family member 3	Homo sapiens	20-26
33446662-6	2021	Simultaneously, activated STAT3 acetylated at lysine 685 translocates to mitochondria to upregulate energy metabolism-related gene transcription.	Lysine	46-52	signal transducer and activator of transcription 3	Homo sapiens	26-31
33450879-0	2021	Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells.	Lysine	0-6	epidermal growth factor receptor	Homo sapiens	61-65
33450879-0	2021	Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells.	Lysine	0-6	epidermal growth factor receptor	Homo sapiens	85-89
33450879-6	2021	In the present study, we established a screening platform based on amino acid deprivation and found that EGFR-mutant NSCLC cells are sensitive to short-term lysine deprivation.	Lysine	157-163	epidermal growth factor receptor	Homo sapiens	105-109
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	55-61	epidermal growth factor receptor	Homo sapiens	201-205
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	55-61	AKT serine/threonine kinase 1	Homo sapiens	206-209
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	140-146	epidermal growth factor receptor	Homo sapiens	201-205
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	140-146	AKT serine/threonine kinase 1	Homo sapiens	206-209
33450879-8	2021	Finally, we found that lysine reduction can not only enhance the cytostatic effect of single-agent osimertinib but also overcome the resistance of EGFR-TKIs in EGFR-mutant NSCLC cells.	Lysine	23-29	epidermal growth factor receptor	Homo sapiens	147-151
33450879-8	2021	Finally, we found that lysine reduction can not only enhance the cytostatic effect of single-agent osimertinib but also overcome the resistance of EGFR-TKIs in EGFR-mutant NSCLC cells.	Lysine	23-29	epidermal growth factor receptor	Homo sapiens	160-164
33450879-9	2021	In summary, our findings suggest that the introduction of lysine stress might act as an advancement in EGFR-mutant NSCLC therapy and offer a strategy to overcome EGFR-TKI resistance.	Lysine	58-64	epidermal growth factor receptor	Homo sapiens	103-107
33450879-9	2021	In summary, our findings suggest that the introduction of lysine stress might act as an advancement in EGFR-mutant NSCLC therapy and offer a strategy to overcome EGFR-TKI resistance.	Lysine	58-64	epidermal growth factor receptor	Homo sapiens	162-166
33084231-7	2021	The expression of Lysyl-tRNA Synthetase (KARS), the enzyme catalysing the charge of lysine to tRNA-Lys-CUU, was significantly upregulated in HCC tumour tissues compared to tumour-free liver tissues.	Lysine	84-90	lysyl-tRNA synthetase 1	Homo sapiens	18-39
33436557-2	2021	We previously showed that EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, and G9, a H3K9 methyltransferase, are potential therapeutic targets in MM.	Lysine	45-51	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	26-30
33431796-11	2021	One of the important mechanisms is that inhibition HDAC2 to reduce pyroptosis may be by modulating the K68 lysine site of ULK1.	Lysine	107-113	histone deacetylase 2	Homo sapiens	51-56
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	CD34 molecule	Homo sapiens	113-117
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	228-234	Ssh4p	Saccharomyces cerevisiae S288C	165-169
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	280-286	Ssh4p	Saccharomyces cerevisiae S288C	165-169
33351099-3	2021	Here, we describe how Ssh4, a yeast E3 ligase adaptor, recognizes the PQ-loop lysine transporter Ypq1 only after lysine starvation.	Lysine	78-84	Ssh4p	Saccharomyces cerevisiae S288C	22-26
33351099-3	2021	Here, we describe how Ssh4, a yeast E3 ligase adaptor, recognizes the PQ-loop lysine transporter Ypq1 only after lysine starvation.	Lysine	113-119	Ssh4p	Saccharomyces cerevisiae S288C	22-26
32882370-7	2021	Pharmacological reduction of hypusination or mutations of lysine residues within the hypusine loop decreased phosphorylated and insoluble TDP-43 levels.	Lysine	58-64	TAR DNA binding protein	Homo sapiens	138-144
32232831-9	2021	Trim21 colocalized with p65/Nuclear factor-kappaB (NF-kappaB) in the cytosol and physically bound and ubiquitinated p65 via a lysine 63 (K63) linkage.	Lysine	126-132	tripartite motif containing 21	Homo sapiens	0-6
33326128-5	2021	Another group of the human herpesvirus family (HHV-1 and 2), causes herpes simplex that is controlled with the antivirals, including acyclovir, as well as the amino acid L-Lysine, both showing positive and similar results in reducing the number of annual manifestations and the healing time of the lesions.	Lysine	170-178	hhv-1 and 2	None	47-58
33289299-3	2021	Recently, we reported the identification of inhibitors of the histone lysine demethylase JMJD1C that preferentially kill MLL rearranged acute leukemia cells.	Lysine	70-76	jumonji domain containing 1C	Homo sapiens	89-95
32758547-0	2021	Lysine-based biodegradable surfactants: Increasing the lipophilicity of insulin by hydrophobic ion paring.	Lysine	0-6	insulin	Homo sapiens	72-79
33160987-5	2021	However, transfection with adenoviral construct including SIRT3 significantly inhibited HG-induced SA-gal activity, decreased p53 acetylation level at the site Lys 320 (k320), and overexpression of SIRT3 antagonized high glucose-induced angiogenic dysfunction.	Lysine	160-163	sirtuin 3	Homo sapiens	58-63
33160987-5	2021	However, transfection with adenoviral construct including SIRT3 significantly inhibited HG-induced SA-gal activity, decreased p53 acetylation level at the site Lys 320 (k320), and overexpression of SIRT3 antagonized high glucose-induced angiogenic dysfunction.	Lysine	160-163	tumor protein p53	Homo sapiens	126-129
33934885-4	2021	In this article, we describe a new role for the ubiquitin-proteasome system in histone crosstalk, showing that learning-induced monoubiquitination of histone H2B (H2Bubi) is required for increases in the transcriptionally active H3 lysine 4 trimethylation (H3K4me3) mark at learning-related genes in the hippocampus.	Lysine	232-238	histone cluster 1, H2bg	Rattus norvegicus	163-169
32950104-3	2021	We found that AICD is SUMO-modified by the SUMO E3 ligase protein inhibitor of activated STAT1 (PIAS1) in the hippocampus at Lys-43 predominantly, and that knockdown of PIAS1 decreases endogenous AICD SUMOylation.	Lysine	125-128	protein inhibitor of activated STAT 1	Mus musculus	58-94
32950104-3	2021	We found that AICD is SUMO-modified by the SUMO E3 ligase protein inhibitor of activated STAT1 (PIAS1) in the hippocampus at Lys-43 predominantly, and that knockdown of PIAS1 decreases endogenous AICD SUMOylation.	Lysine	125-128	protein inhibitor of activated STAT 1	Mus musculus	96-101
32950104-3	2021	We found that AICD is SUMO-modified by the SUMO E3 ligase protein inhibitor of activated STAT1 (PIAS1) in the hippocampus at Lys-43 predominantly, and that knockdown of PIAS1 decreases endogenous AICD SUMOylation.	Lysine	125-128	protein inhibitor of activated STAT 1	Mus musculus	169-174
33397384-3	2021	Therefore, we designed this study to investigate effects of SUV39H2 in OS meditated by the lysine specific demethylase-1/E-cadherin (LSD1/CDH1) axis.	Lysine	91-97	cadherin 1	Homo sapiens	138-142
33931138-6	2021	Here, we describe the predominant epigenetic changes that can affect key KAT superfamily members during carcinogenesis and briefly highlight the pharmacological potential of employing lysine acetyltransferase inhibitors (KATi) for cancer therapy.	Lysine	184-190	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	73-76
33931138-6	2021	Here, we describe the predominant epigenetic changes that can affect key KAT superfamily members during carcinogenesis and briefly highlight the pharmacological potential of employing lysine acetyltransferase inhibitors (KATi) for cancer therapy.	Lysine	184-190	kynurenine aminotransferase 1	Homo sapiens	221-225
32896800-1	2021	A genome-wide association study had shown that lysine methyltransferase 2A (KMT2A), which encodes the histone 3 lysine 4 methyltransferase and reportedly can regulate gametogenesis, steroidogenesis, and development as well as other biological processes, is a potential candidate gene influencing litter size in the dairy goat, suggesting its key function in animal reproduction.	Lysine	47-53	histone-lysine N-methyltransferase 2A	Capra hircus	76-81
33084231-7	2021	The expression of Lysyl-tRNA Synthetase (KARS), the enzyme catalysing the charge of lysine to tRNA-Lys-CUU, was significantly upregulated in HCC tumour tissues compared to tumour-free liver tissues.	Lysine	84-90	lysyl-tRNA synthetase 1	Homo sapiens	41-45
33084231-7	2021	The expression of Lysyl-tRNA Synthetase (KARS), the enzyme catalysing the charge of lysine to tRNA-Lys-CUU, was significantly upregulated in HCC tumour tissues compared to tumour-free liver tissues.	Lysine	18-21	lysyl-tRNA synthetase 1	Homo sapiens	41-45
33315499-0	2021	Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.	Lysine	35-41	DOT1 like histone lysine methyltransferase	Homo sapiens	63-68
33073913-5	2021	The enhanced AGO2 expression is associated with prior-to-activation trimethylation of lysine 4 in histone H3 and acetylation of histone H3 in the AGO2 promoter and with induced resistance to the yellow strain of cucumber mosaic virus (CMV[Y]).	Lysine	86-92	argonaute RISC catalytic component 2	Homo sapiens	13-17
33199825-3	2021	RNF40 and its paralog RNF20 form a stable heterodimer complex that can monoubiquitylate histone H2B at lysine 120 as well as other nonhistone proteins.	Lysine	103-109	ring finger protein 40	Homo sapiens	0-5
33199825-3	2021	RNF40 and its paralog RNF20 form a stable heterodimer complex that can monoubiquitylate histone H2B at lysine 120 as well as other nonhistone proteins.	Lysine	103-109	ring finger protein 20	Homo sapiens	22-27
33122827-11	2021	Mechanistically, downregulation of LINC00261 was caused by hypermethylation of the CpG island in the promoter region and EZH2-mediated histone H3 lysine 27 trimethylation.	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-125
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Lysine	40-43	Auxin efflux carrier family protein	Arabidopsis thaliana	129-133
33523829-3	2021	Here, we removed SETD2, the methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and showed that Setd2 is required for proper cortical arealization and the formation of cortico-thalamo-cortical circuits.	Lysine	60-66	SET domain containing 2	Mus musculus	17-22
33523829-3	2021	Here, we removed SETD2, the methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and showed that Setd2 is required for proper cortical arealization and the formation of cortico-thalamo-cortical circuits.	Lysine	60-66	SET domain containing 2	Mus musculus	156-161
33396715-8	2020	Notably, we identified the lysine 44 residue of IKKalpha as a putative binding site for STAT3.	Lysine	27-33	signal transducer and activator of transcription 3	Homo sapiens	88-93
33339442-1	2020	The histone methyltransferase SETD8, which methylates the lysine 20 of histone H4 (H4K20), is reportedly involved in human carcinogenesis along with nonhistone proteins such as p53.	Lysine	58-64	tumor protein p53	Homo sapiens	177-180
33362245-3	2020	Lysine 63 (K63)-linked polyubiquitination of Tax provides an important regulatory mechanism that promotes Tax-mediated interaction with the IKK complex and activation of NF-kappaB; however, the host proteins regulating Tax ubiquitination are largely unknown.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	170-179
33170267-2	2020	In Arabidopsis thaliana (Arabidopsis), CURLY LEAF (CLF) and SWINGER (SWN) are PRC2 catalytic subunits that repress gene expression through trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	168-174	SET domain-containing protein	Arabidopsis thaliana	60-67
33170267-2	2020	In Arabidopsis thaliana (Arabidopsis), CURLY LEAF (CLF) and SWINGER (SWN) are PRC2 catalytic subunits that repress gene expression through trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	168-174	SET domain-containing protein	Arabidopsis thaliana	69-72
32978169-3	2020	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the enzymatic catalytic subunit of the polycomb repressive complex 2 (PRC2) that can alter gene expression by trimethylating lysine 27 on histone 3 (H3K27).	Lysine	193-199	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
33327550-2	2020	A widely known function of EZH2 is to serve as an enzymatic subunit of Polycomb repressive complex 2 (PRC2) and catalyze trimethylation of histone H3 lysine 27 (H3K27me3) for repressing target gene expression.	Lysine	150-156	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	27-31
33326776-2	2020	Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.	Lysine	90-96	deoxyhypusine synthase	Homo sapiens	0-22
33326776-2	2020	Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.	Lysine	90-96	deoxyhypusine synthase	Homo sapiens	24-28
33188077-6	2020	In this study, we identified potential mouse Il13 enhancers using histone modification monomethylation at lysine residue 4 on histone 3 (H3K4me1) chromatin immunoprecipitation sequencing and acetylation at lysine residue 27 on histone 3 (H3K27ac) chromatin immunoprecipitation sequencing.	Lysine	106-112	interleukin 13	Mus musculus	45-49
33188077-6	2020	In this study, we identified potential mouse Il13 enhancers using histone modification monomethylation at lysine residue 4 on histone 3 (H3K4me1) chromatin immunoprecipitation sequencing and acetylation at lysine residue 27 on histone 3 (H3K27ac) chromatin immunoprecipitation sequencing.	Lysine	206-212	interleukin 13	Mus musculus	45-49
33256805-1	2020	BACKGROUND: The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethylation on lysine 9 of histone H3 (H3K9me3) in mouse embryonic stem cells (mESCs).	Lysine	250-256	SET domain, bifurcated 1	Mus musculus	42-48
33028721-9	2020	Altogether, our data identified multiple surface-exposed lysine residues, located within a basic patch of CDV M-CTD, critically contributing to PM association and ensuing membrane budding activity.IMPORTANCE Although vaccines against some morbilliviruses exist, infections still occur, which can result in dramatic brain disease or fatal outcome.	Lysine	57-63	CTD	Homo sapiens	112-115
32163000-6	2020	Four long primer pairs with sticky end were used to synthesize CGA-N12 expression sequence which contains four copies of CGA-N12 flanked by a Lys-Arg pair and two Glu-Ala repeating units.	Lysine	142-145	chromogranin A	Homo sapiens	63-66
32960990-8	2020	RESULTS: Nine novel PSMA ligands were synthesized by the combination of three azido compounds and three terminal acetylene-containing Glu-urea-Lys compounds.	Lysine	143-146	folate hydrolase 1	Homo sapiens	20-24
33302417-2	2020	The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents.	Lysine	69-72	folate hydrolase 1	Homo sapiens	45-49
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	lysine demethylase 6A	Homo sapiens	106-109
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	115-119
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	twist family bHLH transcription factor 1	Homo sapiens	180-185
33938178-2	2021	Bound to the APP adaptor protein Fe65 and the lysine acetyltransferase (KAT) Tip60, AICD translocates to the nucleus.	Lysine	46-52	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	72-75
33938178-10	2021	A second acetylation/deacetylation cycle, conducted by CBP and class I/II KDACs at different lysine residues, regulates stability of Fe65.	Lysine	93-99	CREB binding protein	Homo sapiens	55-58
33026957-7	2020	The Geometric Means (GM) of AFB1-lysine adducts were 14.0 (95%CI 12.5, 15.7) pg/mg albumin and 8.2 (95%CI 7.6, 8.8) pg/mg albumin (p-value < 0.001), among children recruited from Makueni and Siaya Counties, respectively.	Lysine	33-39	albumin	Homo sapiens	83-90
32676696-4	2020	At the promoter region of the IL-1beta gene, the demethylation of histone H3 lysine 27 (H3K27) was significantly induced for 1 week after transient stimulation with LPS and IFN-gamma.	Lysine	77-83	interferon gamma	Mus musculus	173-182
32900591-7	2020	Mass spectrophotometric analysis revealed that lysine residues in APOA1 and APOA2 of HDL modified by GAD and MDA in vitro differed from those modified by glucose, which resembled that seen with HDL from patients with type1 diabetes.	Lysine	47-53	apolipoprotein A1	Homo sapiens	66-71
32322039-1	2020	EZH2, a component of the polycomb repressive complex 2, catalyses the trimethylation of histone H3 lysine 27, a chromatin mark associated with transcriptional repression.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
33256805-1	2020	BACKGROUND: The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethylation on lysine 9 of histone H3 (H3K9me3) in mouse embryonic stem cells (mESCs).	Lysine	250-256	SET domain, bifurcated 1	Mus musculus	64-68
32969477-1	2020	Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disease caused by mutations in the ALDH7A1 gene leading to blockade of the lysine catabolism pathway.	Lysine	141-147	aldehyde dehydrogenase family 7, member A1	Mus musculus	101-108
33330095-0	2020	Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins.	Lysine	0-6	estrogen receptor 1	Homo sapiens	62-79
33256840-5	2020	Moreover, MEG3 increases the methylation modification of histone H3 at the 27th lysine via P53.	Lysine	80-86	tumor protein p53	Homo sapiens	91-94
33244022-2	2020	Acrolein-treated fibrinogen was subjected to tissue plasminogen activator-induced fibrinolysis assay and the effect of lysine residue carbonylation in fibrinogen on fibrinolysis was analyzed.	Lysine	119-125	fibrinogen beta chain	Homo sapiens	151-161
33244022-3	2020	The acrolein-treated fibrinogen-derived fibrin clot appeared more resistant to fibrinolysis and the N-acetyl 3-formyl-3,4-dehydropiperidino (FDP)-Lysine levels in the lysed solution were positively correlated with the duration of clot lysis.	Lysine	146-152	fibrinogen beta chain	Homo sapiens	21-31
33244022-6	2020	These results suggest that fibrinogen carbonylation by acrolein to generate N-acetyl FDP-Lysine resulted in the generation of fibrinolysis-resistant fibrin by attenuating the C-terminal lysine-dependent activation of the Glu1-plasminogen.	Lysine	186-192	fibrinogen beta chain	Homo sapiens	27-37
32816380-5	2020	We report novel fragments which bind specifically to a lysine at the PPI interface of the p65 subunit-derived peptide of NF-kappaB with the adapter protein 14-3-3.	Lysine	55-61	nuclear factor kappa B subunit 1	Homo sapiens	121-130
32649985-6	2020	Upon ROS exposure, UNG2 is deacetylated at lysine 78 by histone deacetylases, which prevents the UNG2-UHRF1 interaction.	Lysine	43-49	uracil DNA glycosylase	Homo sapiens	19-23
33299528-3	2020	We previously reported that SUMOylation at lysine residue 110 is important for the ability of NRF2 to promote reactive oxygen species (ROS) clearance in hepatocellular carcinoma.	Lysine	43-49	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
32649985-6	2020	Upon ROS exposure, UNG2 is deacetylated at lysine 78 by histone deacetylases, which prevents the UNG2-UHRF1 interaction.	Lysine	43-49	uracil DNA glycosylase	Homo sapiens	97-101
32882416-1	2020	CBP bromodomain could recognize acetylated lysine and function as transcription coactivator to regulate transcription and downstream gene expression.	Lysine	43-49	CREB binding protein	Homo sapiens	0-3
32900482-4	2020	In this study, we found IDH2 is modified by small ubiquitin-like modifier 1 (SUMO1) at lysine 45.	Lysine	87-93	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	24-28
33207561-3	2020	Enhancer of zeste homolog 2 (EZH2) catalyzes methylation on Lys 27 of histone H3, which leads to chromatin compaction and gene silencing.	Lysine	60-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
33207561-3	2020	Enhancer of zeste homolog 2 (EZH2) catalyzes methylation on Lys 27 of histone H3, which leads to chromatin compaction and gene silencing.	Lysine	60-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
33184450-5	2021	The SUMOylation sites of TAB2 mediated by TRIM60 were identified as K329 and K562; substitution of these lysines with arginines abolished the SUMOylation of TAB2.	Lysine	105-112	tripartite motif-containing 60	Mus musculus	42-48
33187982-4	2021	Aurora B kinase elicits a cascade of events starting with phosphorylation of histone H3 serine 10 (H3S10ph), which signals the recruitment of lysine deacetylase Hst2 and the removal of lysine 16 acetylation in histone 4 (H4).	Lysine	142-148	histone deacetylase HST2	Saccharomyces cerevisiae S288C	161-165
33180886-5	2020	The results obtained by transfection assays of recombinant wild type and mutated forms of Danio rerio Fabp2 in Caco-2 cell cultures, showed that lysine 17, arginine 29 and lysine 30 residues, which are located in the helix-turn-helix region, would constitute a functional non-classical three-dimensional NLS.	Lysine	145-151	fatty acid binding protein 2, intestinal	Danio rerio	102-107
33180886-5	2020	The results obtained by transfection assays of recombinant wild type and mutated forms of Danio rerio Fabp2 in Caco-2 cell cultures, showed that lysine 17, arginine 29 and lysine 30 residues, which are located in the helix-turn-helix region, would constitute a functional non-classical three-dimensional NLS.	Lysine	172-178	fatty acid binding protein 2, intestinal	Danio rerio	102-107
32986841-7	2020	BAP18 is recruited to the promoter regions of estrogen-induced genes, accompanied with the enrichment of the lysine 4-trimethylated histone H3 tail (H3K4me3) in the presence of E2.	Lysine	109-115	chromosome 17 open reading frame 49	Homo sapiens	0-5
33187138-1	2020	Ezh2 is a catalytic subunit of the polycomb repressive complex 2 (PRC2) which mediates epigenetic gene silencing through depositing the mark histone H3 lysine 27 trimethylation (H3K27me3) at target genomic sequences.	Lysine	152-158	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
33204871-3	2020	Here, we report a novel crosslinked type of AGE, named as lactaldehyde-derived lysine dimer (LAK2), which is produced due to non-enzymatic glycation of N alpha-acetyl-L-lysine with lactaldehyde under physiological conditions.	Lysine	79-85	renin binding protein	Homo sapiens	44-47
33010166-1	2020	In yeast, NuA3 histone acetyltransferase (NuA3 HAT) promotes acetylation of histone H3 lysine 14 (H3K14) and transcription of a subset of genes through interaction between the Yng1 plant homeodomain (PHD) finger and H3K4me3.	Lysine	87-93	Yng1p	Saccharomyces cerevisiae S288C	176-180
32747424-6	2020	Furthermore, the downregulation of several TAGs in T2D (including CLDN10, CLDN14, CLDN16, SLC16A2, SLC16A5) was associated with promoter hypermethylation, decreased chromatin accessibility and reduced enrichment of HNF4A, histone H3-lysine-27-acetylation, and CTCF.	Lysine	233-239	claudin 10	Homo sapiens	66-72
32814032-3	2020	Here, we present a high-resolution structure of a ULK4-ATPgammaS complex revealing a highly unusual ATP binding mode in which the lack of the canonical VAIK motif lysine is compensated by K39, located N-terminal to alphaC.	Lysine	163-169	unc-51 like kinase 4	Homo sapiens	50-54
32930811-0	2020	Fewer Exposed Lysine Residues May Explain Relative Resistance of Chicken Serum Albumin to In Vitro Protein Glycation in Comparison to Bovine Serum Albumin.	Lysine	14-20	albumin	Homo sapiens	79-86
32930811-0	2020	Fewer Exposed Lysine Residues May Explain Relative Resistance of Chicken Serum Albumin to In Vitro Protein Glycation in Comparison to Bovine Serum Albumin.	Lysine	14-20	albumin	Homo sapiens	73-86
32930811-10	2020	Moreover, comparisons of reconstructed ancestral albumin sequences show that the ancestor of birds had 6-8 fewer lysine residues compared to that of mammals.	Lysine	113-119	albumin	Homo sapiens	49-56
32933418-2	2020	EZH2 (enhancer of zeste homolog 2)-mediated H3K27Me3 (trimethylation of histone 3 lysine 27) has been recognized to play a critical role in multiple inflammatory diseases.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	0-4
32569093-6	2020	CRMP2, modified at Lysine 374 (K374) by addition of a small ubiquitin-like modifier (SUMO), bound NaV1.7 to regulate its membrane localization and function.	Lysine	19-25	dihydropyrimidinase like 2	Homo sapiens	0-5
32933418-2	2020	EZH2 (enhancer of zeste homolog 2)-mediated H3K27Me3 (trimethylation of histone 3 lysine 27) has been recognized to play a critical role in multiple inflammatory diseases.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	6-33
33082289-6	2020	Dimerization is stimulated by the lysine-rich carboxyl-terminal extension of UBE2S that is also required for the recruitment of this E2 to the APC/C and is autoubiquitinated as substrate abundance becomes limiting.	Lysine	34-40	ubiquitin conjugating enzyme E2 S	Homo sapiens	77-82
32777075-12	2020	To conclude, we show that amoxicillin-modified peptides bind to both components of the risk haplotype to stimulate DILI patient T-cells and describe the importance of the position of nucleophilic lysine residue in the HLA binding peptide sequence.	Lysine	196-202	major histocompatibility complex, class II, DR beta 1	Homo sapiens	218-221
32991149-4	2020	Remarkably, the 15 remaining Lys in cyt c are not susceptible to carbonylation.	Lysine	29-32	cytochrome c, somatic	Homo sapiens	36-41
33192599-2	2020	One of the currently best described roles of Cl- in signaling is the modulation of the With-No-Lysine (K) (WNK) - STE20-Proline Alanine rich Kinase (SPAK)/Oxidative Stress Responsive Kinase 1 (OSR1) - Cation-Coupled Cl- Cotransporters (CCCs) cascade.	Lysine	95-101	serine/threonine kinase 39	Homo sapiens	149-153
33088589-1	2020	Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on virtually all actively transcribed protein-coding genes, and this mechanism is evolutionarily conserved from yeast to human.	Lysine	51-57	SET domain containing 2	Mus musculus	0-5
32679234-6	2020	The interaction between miR-93-5p and lysine (K)-specific demethylase 6B (KDM6B) was identified using dual-luciferase reporter assay, and ChIP was used to validate the relationship between KDM6B and tumor necrosis factor-alpha (TNF-alpha).	Lysine	38-44	tumor necrosis factor	Mus musculus	199-226
32796032-4	2020	HDAC6 interacts with TRIM21 through its PRYSPRY motif and deacetylates TRIM21 at lysine 385 and lysine 387, thus promoting its homodimerization.	Lysine	81-87	histone deacetylase 6	Homo sapiens	0-5
32796032-4	2020	HDAC6 interacts with TRIM21 through its PRYSPRY motif and deacetylates TRIM21 at lysine 385 and lysine 387, thus promoting its homodimerization.	Lysine	81-87	tripartite motif containing 21	Homo sapiens	21-27
32796032-4	2020	HDAC6 interacts with TRIM21 through its PRYSPRY motif and deacetylates TRIM21 at lysine 385 and lysine 387, thus promoting its homodimerization.	Lysine	81-87	tripartite motif containing 21	Homo sapiens	71-77
32796032-4	2020	HDAC6 interacts with TRIM21 through its PRYSPRY motif and deacetylates TRIM21 at lysine 385 and lysine 387, thus promoting its homodimerization.	Lysine	96-102	histone deacetylase 6	Homo sapiens	0-5
32796032-4	2020	HDAC6 interacts with TRIM21 through its PRYSPRY motif and deacetylates TRIM21 at lysine 385 and lysine 387, thus promoting its homodimerization.	Lysine	96-102	tripartite motif containing 21	Homo sapiens	21-27
32862843-8	2020	The strong interaction between lysine functionalized BiVO4 and hyaluronic acid enabled biosensor to exhibit robust antifouling characteristics towards similar proteins such as PSA and NSE.	Lysine	31-37	enolase 2	Homo sapiens	184-187
32855205-4	2020	Screening of five human chordoma cell lines revealed that pharmacologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) leads to cell death.	Lysine	100-106	lysine demethylase 6A	Homo sapiens	123-128
32855205-4	2020	Screening of five human chordoma cell lines revealed that pharmacologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) leads to cell death.	Lysine	100-106	lysine demethylase 6A	Homo sapiens	130-133
32679234-6	2020	The interaction between miR-93-5p and lysine (K)-specific demethylase 6B (KDM6B) was identified using dual-luciferase reporter assay, and ChIP was used to validate the relationship between KDM6B and tumor necrosis factor-alpha (TNF-alpha).	Lysine	38-44	tumor necrosis factor	Mus musculus	228-237
33011750-3	2020	EZH2 and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) was previously shown ectopically expressed in carcinoma and mediated proliferation, thereby we sought to clarify the role of EZH2-H3K27me3 in the proliferation of psoriatic keratinocyte.	Lysine	52-58	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
33051544-3	2020	In our current work, we identified lysine 473 (K473) on PAK4 as the primary methylation site by SETD6.	Lysine	35-41	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	96-101
33240782-4	2020	USP38 specifically removes the monoubiquitin on H2B at lysine 120, which functions as a prerequisite for the subsequent recruitment of demethylase KDM5B to the promoters of proinflammatory cytokines Il6 and Il23a during LPS stimulation.	Lysine	55-61	ubiquitin specific peptidase 38	Mus musculus	0-5
33240782-4	2020	USP38 specifically removes the monoubiquitin on H2B at lysine 120, which functions as a prerequisite for the subsequent recruitment of demethylase KDM5B to the promoters of proinflammatory cytokines Il6 and Il23a during LPS stimulation.	Lysine	55-61	interleukin 6	Mus musculus	199-202
32926780-3	2020	Herein, we probed recognition of lysine crotonylation and acetylation by the AF9 YEATS domain through incorporation of non-canonical Phe analogs with distinct electrostatics at two positions.	Lysine	33-39	MLLT3 super elongation complex subunit	Homo sapiens	77-80
33027667-2	2020	We report here that PKCepsilon is SUMOylated at a C-terminal lysine residue (K534), which enhances the sensitivity of the TRPV1 channel.	Lysine	61-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	122-127
33117406-1	2020	Enhancer of zeste 2 (EZH2) is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) that mediates di- and trimethylation of histone 3 lysine 27 effectively precluding successful gene transcription at these loci.	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	21-25
33011750-0	2020	EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation.	Lysine	51-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
32929041-6	2020	This phosphorylation event also stabilizes NLRP3 by reducing its ubiquitination on lysine 496, which inhibits its proteasome-mediated degradation by the E3 ligase Trim31.	Lysine	83-89	NLR family pyrin domain containing 3	Homo sapiens	43-48
32929041-6	2020	This phosphorylation event also stabilizes NLRP3 by reducing its ubiquitination on lysine 496, which inhibits its proteasome-mediated degradation by the E3 ligase Trim31.	Lysine	83-89	tripartite motif containing 31	Homo sapiens	163-169
32955251-3	2020	WT1 has two major splice variants, where the tripeptide Lys-Thr-Ser (KTS) is inserted in the linker between the third and fourth zinc fingers.	Lysine	56-59	WT1 transcription factor	Homo sapiens	0-3
33063698-5	2021	One of the important subunits of PcG group of protein is EZH2 (a histone methyltransferase), which catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery and induces silencing of specific gene transcription.	Lysine	142-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	57-61
33123537-1	2020	The substitution of the seventeenth amino acid glutamate by lysine in the homologous structural domain of the Akt1 gene pleckstrin is a somatic cellular mutation found in breast, colorectal, and ovarian cancers, named p. Glu17Lys or E17K.	Lysine	60-66	AKT serine/threonine kinase 1	Homo sapiens	110-114
33011750-3	2020	EZH2 and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) was previously shown ectopically expressed in carcinoma and mediated proliferation, thereby we sought to clarify the role of EZH2-H3K27me3 in the proliferation of psoriatic keratinocyte.	Lysine	52-58	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	9-13
33011750-3	2020	EZH2 and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) was previously shown ectopically expressed in carcinoma and mediated proliferation, thereby we sought to clarify the role of EZH2-H3K27me3 in the proliferation of psoriatic keratinocyte.	Lysine	52-58	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	9-13
33008892-3	2020	Here, we show that SETD2 is an actin methyltransferase that trimethylates lysine-68 (ActK68me3) in cells via its interaction with HTT and the actin-binding adapter HIP1R.	Lysine	74-80	actin	Saccharomyces cerevisiae S288C	31-36
33133132-1	2020	SETDB1, a histone H3 lysine 9 (H3K9) methyltransferase, is crucial in meiosis and embryo development.	Lysine	21-27	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
33008892-3	2020	Here, we show that SETD2 is an actin methyltransferase that trimethylates lysine-68 (ActK68me3) in cells via its interaction with HTT and the actin-binding adapter HIP1R.	Lysine	74-80	actin	Saccharomyces cerevisiae S288C	142-147
32564302-11	2020	The downregulation of BAPN-induced MMP2 expression by SIRT1 was mediated by deacetylation of histone H3 lysine 9 (H3K9) on the Mmp2 promoter in the A7r5 cells.	Lysine	104-110	sirtuin 1	Rattus norvegicus	54-59
32454355-8	2020	Results of chromatin immunoprecipitation (ChIP)-qPCR assay found that binding levels of acetylated histone 3 lysine 9 (H3K9ac) in GATA4 promoter region in the hearts of ME or FE were markedly decreased compared with their corresponding control groups.	Lysine	109-115	GATA binding protein 4	Mus musculus	130-135
32394628-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing tri-methylation marks at lysine 27 of histone H3 (H3K27me3).	Lysine	278-284	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
32394628-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing tri-methylation marks at lysine 27 of histone H3 (H3K27me3).	Lysine	278-284	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
32816857-2	2020	EZH2 expression results in the silencing of genes that suppress tumor formation and metastasis through trimethylation of histone H3 at lysine 27 (H3K27me3) at their promoters.	Lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
32816857-4	2020	Here, we show that SUMOylation, a posttranslational modification characterized by covalent attachment of small ubiquitin-like modifier (SUMO) proteins to a lysine (Lys) residue on target proteins, enhances EZH2 transcription.	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	206-210
32816857-4	2020	Here, we show that SUMOylation, a posttranslational modification characterized by covalent attachment of small ubiquitin-like modifier (SUMO) proteins to a lysine (Lys) residue on target proteins, enhances EZH2 transcription.	Lysine	164-167	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	206-210
32707526-4	2020	This review surveys the common covalent targets in B1 and B2 MbetaLs, summarizes all covalent inhibitors of MbetaLs and their inhibition modes as of 2020, highlights the importance of the rational design of covalent MbetaL inhibitor guided by the crystal structure and the development of dual-action covalent MbetaL/SbetaL inhibitors based on lysine residue of MbetaLs and serine residue of SbetaLs, and describes the approaches to discern the covalent inhibition mechanism to guide the development of future therapeutics.	Lysine	343-349	mal, T cell differentiation protein	Homo sapiens	108-114
32736194-3	2020	We and others recently demonstrated that acetylation of NLRP3 promotes the inflammasome activity and also suggested lysine acetyltransferases inhibitors could be a kind of promising agents for treating NLRP3 associated disorders.	Lysine	116-122	NLR family pyrin domain containing 3	Homo sapiens	56-61
32454110-4	2020	It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted.	Lysine	34-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
32736194-3	2020	We and others recently demonstrated that acetylation of NLRP3 promotes the inflammasome activity and also suggested lysine acetyltransferases inhibitors could be a kind of promising agents for treating NLRP3 associated disorders.	Lysine	116-122	NLR family pyrin domain containing 3	Homo sapiens	202-207
32879443-5	2020	We demonstrated that knockdown of JMJD8 increased the interaction of SETDB1 and phosphoinositide-dependent kinase 1 (PDK1) with AKT1 and resulted in enhanced trimethylation of AKT1 at lysine 142 (K142), which is crucial for cell membrane recruitment, phosphorylation, and activation of AKT.	Lysine	184-190	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	69-75
32801097-1	2020	Lysyl oxidase-like 2 (LOXL2) is a copper-dependent amine oxidase that catalyzes the oxidative deamination of the epsilon-amino group of lysines/hydroxylysines on substrate proteins (collagen and elastin) to form aldehyde groups.	Lysine	136-143	lysyl oxidase like 2	Homo sapiens	0-20
32801097-1	2020	Lysyl oxidase-like 2 (LOXL2) is a copper-dependent amine oxidase that catalyzes the oxidative deamination of the epsilon-amino group of lysines/hydroxylysines on substrate proteins (collagen and elastin) to form aldehyde groups.	Lysine	136-143	lysyl oxidase like 2	Homo sapiens	22-27
32855270-1	2020	Enhancer of Zester Homolog 2 (EZH2), a histone lysine methyltransferase and the catalytic component of Polycomb Repressive Complex 2, has been extensively investigated as a chromatin regulator and a transcriptional suppressor by methylating H3 at lysine 27 (H3K27).	Lysine	47-53	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-28
32855270-1	2020	Enhancer of Zester Homolog 2 (EZH2), a histone lysine methyltransferase and the catalytic component of Polycomb Repressive Complex 2, has been extensively investigated as a chromatin regulator and a transcriptional suppressor by methylating H3 at lysine 27 (H3K27).	Lysine	47-53	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
32885602-6	2020	We further determined that HDAC6 regulated the autophagy partially by decreasing the acetylation of alpha-tubulin at the residue of lysine 40.	Lysine	132-138	histone deacetylase 6	Mus musculus	27-32
32879443-5	2020	We demonstrated that knockdown of JMJD8 increased the interaction of SETDB1 and phosphoinositide-dependent kinase 1 (PDK1) with AKT1 and resulted in enhanced trimethylation of AKT1 at lysine 142 (K142), which is crucial for cell membrane recruitment, phosphorylation, and activation of AKT.	Lysine	184-190	AKT serine/threonine kinase 1	Homo sapiens	176-180
32879445-0	2020	Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.	Lysine	10-16	lysine demethylase 6A	Homo sapiens	32-37
32691043-0	2020	Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.	Lysine	0-6	FUS RNA binding protein	Homo sapiens	98-101
33003453-3	2020	STAT3 undergoes diverse post-translational modifications, such as the oxidation of cysteine by oxidative stress, the acetylation of lysine, or the phosphorylation of serine/threonine.	Lysine	132-138	signal transducer and activator of transcription 3	Homo sapiens	0-5
32691043-5	2020	In this study, we discovered that FUS was acetylated at lysine-315/316 (K315/K316) and lysine-510 (K510) residues in two distinct domains.	Lysine	56-62	FUS RNA binding protein	Homo sapiens	34-37
32691043-5	2020	In this study, we discovered that FUS was acetylated at lysine-315/316 (K315/K316) and lysine-510 (K510) residues in two distinct domains.	Lysine	87-93	FUS RNA binding protein	Homo sapiens	34-37
32967340-1	2020	Paraoxonase 1 (PON1) is the high density lipoprotein-associated esterase which inhibits the development of atherosclerosis by metabolizing lipid peroxidation products as well as hydrolyzing proatherogenic metabolite of homocysteine (Hcy), Hcy thiolactone, which otherwise reacts with lysine groups of proteins, thus forming N-Hcy-protein in a process referred to as protein N-homocysteinylation.	Lysine	284-290	paraoxonase 1	Homo sapiens	0-13
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	lysine demethylase 6A	Homo sapiens	0-21
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	lysine demethylase 6A	Homo sapiens	23-28
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	lysine demethylase 6A	Homo sapiens	45-48
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	Homo sapiens	143-146
32817139-3	2020	KDM6A physically associates with histone H3 lysine 4 monomethyltransferases MLL3 (KMT2C) and MLL4 (KMT2D).	Lysine	44-50	lysine demethylase 6A	Homo sapiens	0-5
32977832-4	2020	In neural stem cells, UTX has a less influence over histone H3 lysine 27 and lysine 4 methylation but more predominantly affects histone H3 lysine 27 acetylation and chromatin accessibility.	Lysine	63-69	lysine demethylase 6A	Homo sapiens	22-25
32977832-4	2020	In neural stem cells, UTX has a less influence over histone H3 lysine 27 and lysine 4 methylation but more predominantly affects histone H3 lysine 27 acetylation and chromatin accessibility.	Lysine	77-83	lysine demethylase 6A	Homo sapiens	22-25
32977832-4	2020	In neural stem cells, UTX has a less influence over histone H3 lysine 27 and lysine 4 methylation but more predominantly affects histone H3 lysine 27 acetylation and chromatin accessibility.	Lysine	77-83	lysine demethylase 6A	Homo sapiens	22-25
32967340-1	2020	Paraoxonase 1 (PON1) is the high density lipoprotein-associated esterase which inhibits the development of atherosclerosis by metabolizing lipid peroxidation products as well as hydrolyzing proatherogenic metabolite of homocysteine (Hcy), Hcy thiolactone, which otherwise reacts with lysine groups of proteins, thus forming N-Hcy-protein in a process referred to as protein N-homocysteinylation.	Lysine	284-290	paraoxonase 1	Homo sapiens	15-19
32789493-5	2020	SIRT6 deacetylated DDB2 at two lysine residues, K35 and K77, upon UV stress and then promoted DDB2 ubiquitination and segregation from chromatin, thereby facilitating downstream signaling.	Lysine	31-37	cyclin dependent kinase 8	Homo sapiens	48-51
32828318-4	2020	Here we identified that an orphan F-box protein, FBXO24, that binds to 270 to 275 amino acid residues of PRMT6 to cause polyubiquitination of lysine at position 369 of PRMT6, which mediates its degradation via the ubiquitin-proteasome pathway.	Lysine	142-148	F-box protein 24	Homo sapiens	49-55
32947765-0	2020	Coupling of HSP72 alpha-Helix Subdomains by the Unexpected Irreversible Targeting of Lysine-56 over Cysteine-17; Coevolution of Covalent Bonding.	Lysine	85-91	heat shock protein family A (Hsp70) member 1A	Homo sapiens	12-17
32947765-3	2020	The unexpected covalent inhibition of heat shock protein 72 (HSP72) by covalently targeting Lys-56 instead of Cys-17 was an interesting observation.	Lysine	92-95	heat shock protein family A (Hsp70) member 1A	Homo sapiens	38-59
32947765-3	2020	The unexpected covalent inhibition of heat shock protein 72 (HSP72) by covalently targeting Lys-56 instead of Cys-17 was an interesting observation.	Lysine	92-95	heat shock protein family A (Hsp70) member 1A	Homo sapiens	61-66
32947765-8	2020	The closed conformation maintained the crucial salt-bridge between Glu-268 and Lys-56 residues, which strengthens the interaction affinity of the inhibitor nearly identical to adenosine triphosphate (ADP/Pi) bound to the HSP72-NBD.	Lysine	79-82	heat shock protein family A (Hsp70) member 1A	Homo sapiens	221-226
32938017-4	2020	This regulation involves the interplay of histone modifications and DNA methylation states in the human NFE2L2/KEAP1 and murine Nfe2l2/Keap1 genes, acetylation of lysine residues in NRF2 and Nrf2, interaction with bromodomain and extraterminal domain (BET) acetyl "reader" proteins, and non-coding RNAs such as microRNA (miRNA) and long non-coding RNA (lncRNA).	Lysine	163-169	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-186
32828318-4	2020	Here we identified that an orphan F-box protein, FBXO24, that binds to 270 to 275 amino acid residues of PRMT6 to cause polyubiquitination of lysine at position 369 of PRMT6, which mediates its degradation via the ubiquitin-proteasome pathway.	Lysine	142-148	protein arginine methyltransferase 6	Homo sapiens	105-110
32828318-4	2020	Here we identified that an orphan F-box protein, FBXO24, that binds to 270 to 275 amino acid residues of PRMT6 to cause polyubiquitination of lysine at position 369 of PRMT6, which mediates its degradation via the ubiquitin-proteasome pathway.	Lysine	142-148	protein arginine methyltransferase 6	Homo sapiens	168-173
32701294-5	2020	Within the cartilage, glucose and lysine were elevated following TNF-alpha/IL-1beta treatment whilst adenosine, alanine, betaine, creatine, myo-inositol and uridine decreased.	Lysine	34-40	tumor necrosis factor	Equus caballus	65-74
32908002-2	2020	Here, we report that increased amounts of histone 3 lysine 4 demethylase KDM5A in tumors markedly improved response to the treatment with the programmed cell death protein 1 (PD-1) antibody in mouse cancer models.	Lysine	52-58	programmed cell death 1	Mus musculus	142-173
32908002-2	2020	Here, we report that increased amounts of histone 3 lysine 4 demethylase KDM5A in tumors markedly improved response to the treatment with the programmed cell death protein 1 (PD-1) antibody in mouse cancer models.	Lysine	52-58	programmed cell death 1	Mus musculus	175-179
32805486-6	2020	Mechanistically, linc00174 directly bound to enhancer of zeste homolog 2 (EZH2), thus stimulating the protein level of trimethylation at lysine 27 of histone H3 (H3K27me3).	Lysine	137-143	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-72
32805486-6	2020	Mechanistically, linc00174 directly bound to enhancer of zeste homolog 2 (EZH2), thus stimulating the protein level of trimethylation at lysine 27 of histone H3 (H3K27me3).	Lysine	137-143	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	74-78
33083717-6	2020	Both basal and oxidative stress-induced localization of PTEN in the nucleus require ubiquitination of lysine 13 in PTEN.	Lysine	102-108	phosphatase and tensin homolog	Mus musculus	56-60
33083717-6	2020	Both basal and oxidative stress-induced localization of PTEN in the nucleus require ubiquitination of lysine 13 in PTEN.	Lysine	102-108	phosphatase and tensin homolog	Mus musculus	115-119
32669362-7	2020	We identified four lysine residues as the sites of ubiquitination, and showed that replacement of one of them with acetylation-mimicking glutamine increases the sensitivity of mutant EGFR to erlotinib-induced degradation.	Lysine	19-25	epidermal growth factor receptor	Homo sapiens	183-187
32779886-4	2020	Based on the findings that increased protein level of histone H3 lysine 4 (H3K4) methyltransferase Smyd3 and elevated H3K4me3 modification happened in angiotensin II (Ang II)-induced senescence in rat endothelial cells, we are curious about whether and how Smyd3 can regulate endothelial senescence.	Lysine	65-71	angiotensinogen	Rattus norvegicus	167-173
32888405-4	2020	Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA.	Lysine	0-6	SMAD family member 7	Homo sapiens	14-19
32888405-4	2020	Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA.	Lysine	0-6	histone deacetylase 6	Homo sapiens	84-89
32520409-2	2020	Acyl-CoA synthetase family member 3 (ACSF3), which is involved in the regulation of fatty acid metabolism, was predicted to contain lysine acetylation sites related to the mitochondrial deacetylase sirtuin 3 (SIRT3).	Lysine	132-138	acyl-CoA synthetase family member 3	Mus musculus	0-35
32799103-2	2020	DOT1L (disruptor of telomeric silencing 1-like) is the only known methylation writer at histone 3 lysine 79 (H3K79).	Lysine	98-104	DOT1 like histone lysine methyltransferase	Rattus norvegicus	0-5
32520409-2	2020	Acyl-CoA synthetase family member 3 (ACSF3), which is involved in the regulation of fatty acid metabolism, was predicted to contain lysine acetylation sites related to the mitochondrial deacetylase sirtuin 3 (SIRT3).	Lysine	132-138	acyl-CoA synthetase family member 3	Mus musculus	37-42
32586983-1	2020	Pygopus 2 (Pygo2) is a coactivator of Wnt/beta-catenin signaling that can bind bi- or trimethylated lysine 4 of histone-3 (H3K4me2/3) and participate in chromatin reading and writing.	Lysine	100-106	pygopus 2	Mus musculus	0-9
32473242-1	2020	The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9, and upregulation of SETDB1 is associated with poor prognosis in cancer patients.	Lysine	94-100	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	30-36
32586983-1	2020	Pygopus 2 (Pygo2) is a coactivator of Wnt/beta-catenin signaling that can bind bi- or trimethylated lysine 4 of histone-3 (H3K4me2/3) and participate in chromatin reading and writing.	Lysine	100-106	pygopus 2	Mus musculus	11-16
32651255-2	2020	All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acetylated lysine residues in the N-terminal regions of histones.	Lysine	119-125	defensin beta 1	Homo sapiens	57-60
32651255-2	2020	All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acetylated lysine residues in the N-terminal regions of histones.	Lysine	119-125	defensin beta 4A	Homo sapiens	65-68
32677374-7	2020	Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells.	Lysine	146-152	differentiation antagonizing non-protein coding RNA	Homo sapiens	96-101
32498134-9	2020	This unique localization and activity of Acot9 directed acetyl-CoA away from protein lysine acetylation and towards the citric acid (TCA) cycle.	Lysine	85-91	acyl-CoA thioesterase 9	Mus musculus	41-46
32765772-1	2020	Lysine demethylase 6A (KDM6A) is a Jumonji-C domain-containing histone demethylase that specifically catalyzes the removal of histone H3 lysine-27 trimethylation.	Lysine	137-143	lysine demethylase 6A	Homo sapiens	0-21
32765772-1	2020	Lysine demethylase 6A (KDM6A) is a Jumonji-C domain-containing histone demethylase that specifically catalyzes the removal of histone H3 lysine-27 trimethylation.	Lysine	137-143	lysine demethylase 6A	Homo sapiens	23-28
33054052-0	2020	SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.	Lysine	27-33	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
33732505-6	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) and subsequently suppresses transcription of genes bound by such histones.	Lysine	148-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
33732505-6	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) and subsequently suppresses transcription of genes bound by such histones.	Lysine	148-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	141-147	sirtuin 3	Homo sapiens	0-9
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	141-147	sirtuin 3	Homo sapiens	11-16
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	158-164	sirtuin 3	Homo sapiens	0-9
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	158-164	sirtuin 3	Homo sapiens	11-16
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	158-164	sirtuin 3	Homo sapiens	0-9
33015038-4	2020	Sirtuin 3 (SIRT3) is the major mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which deacetylates two critical lysine residues (lysine 68 and lysine 122) on SOD2 and promotes its antioxidative activity.	Lysine	158-164	sirtuin 3	Homo sapiens	11-16
32574379-2	2020	This Editorial highlights a study by Aliu and colleagues in the current issue of the Journal of Neurochemistry, in which the investigators constructed a biodegradable poly-l-lysine backbone with multiple copies of this sulfated HNK-1 trisaccharide.	Lysine	167-180	beta-1,3-glucuronyltransferase 1	Homo sapiens	228-233
32345914-0	2020	Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia via attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription.	Lysine	94-100	WD repeat domain 5	Homo sapiens	16-20
32506822-13	2020	Mass spectrometry identified K556 on the fibrinogen alpha-chain as a potential thrombin cleavage site that generates a TAFIa sensitive C-terminal lysine residue.	Lysine	146-152	coagulation factor II	Mus musculus	79-87
32565234-0	2020	Retraction notice to "Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16" [Life Sci.	Lysine	154-160	mitogen-activated protein kinase 3	Homo sapiens	41-47
32983963-3	2020	We innovatively confirmed that SIRT6 overexpression depleted histone H3 lysine 56 acetylation (H3K56ac) of the negative regulator of reactive oxygen species (NRROS) in vitro, thus increasing reactive oxygen species (ROS) production.	Lysine	72-78	sirtuin 6	Mus musculus	31-36
32598986-10	2020	Moreover, HHE and HNE induced extensive apo-SOD1 modifications, by forming Schiff bases or Michael adducts with Lys, His, and Cys residues.	Lysine	112-115	superoxide dismutase 1	Homo sapiens	44-48
32647014-6	2020	WT pol mu, lacking homologous lysines, displayed nonspecific DNA binding behavior similar to that of pol beta KDelta3A, in line with previous data demonstrating both enzymes were deficient in processive searching.	Lysine	30-37	polymerase (DNA directed), mu	Mus musculus	3-9
32814769-1	2020	The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined.	Lysine	47-53	DOT1 like histone lysine methyltransferase	Homo sapiens	4-35
33014799-10	2020	Knockdown of LINC00673 significantly enhanced posttranscriptional expression of CDKN2C, and histone 3 lysine 27 trimethylation (H3K27me3) was enriched at the promoter region of CDKN2C.	Lysine	102-108	cyclin dependent kinase inhibitor 2C	Homo sapiens	177-183
32786404-4	2020	Parkin-dependent ubiquitylation of LTF occurred most often on lysines (K) 182 and 649.	Lysine	62-69	lactotransferrin	Homo sapiens	35-38
32831651-11	2020	Results: Here, using a panel of OSCC cell lines with wild type or mutant p53, we show that p33ING1b expression is correlated to acetylation of p53 at lysine 382 residue.	Lysine	150-156	tumor protein p53	Homo sapiens	143-146
32702237-8	2020	Of note, modification of lysine residues on either proMMP-1 or TIMP-1 ablated the ability of the MMP-1/TIMP-1 complex to bind to LRP1.	Lysine	25-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	63-69
32702237-8	2020	Of note, modification of lysine residues on either proMMP-1 or TIMP-1 ablated the ability of the MMP-1/TIMP-1 complex to bind to LRP1.	Lysine	25-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	103-109
32702237-8	2020	Of note, modification of lysine residues on either proMMP-1 or TIMP-1 ablated the ability of the MMP-1/TIMP-1 complex to bind to LRP1.	Lysine	25-31	LDL receptor related protein 1	Homo sapiens	129-133
32611769-0	2020	Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.	Lysine	76-79	methyltransferase 21C, AARS1 lysine	Homo sapiens	0-26
32363646-6	2020	We then use our two-step procedure to identify a set of Lysine-related metabolites that potentially mediate the known relationship between increased body mass index and the increased risk of estrogen-receptor positive breast cancer in postmenopausal women.	Lysine	56-62	estrogen receptor 1	Homo sapiens	191-208
32474020-7	2020	In addition, we also found that hypoxia promotes sumoylation in keloids and that HIF-1alpha is covalently modified by SUMO1 at Lys 391 and Lys 477 in HKFs.	Lysine	127-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
32474020-7	2020	In addition, we also found that hypoxia promotes sumoylation in keloids and that HIF-1alpha is covalently modified by SUMO1 at Lys 391 and Lys 477 in HKFs.	Lysine	139-142	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
32611769-0	2020	Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.	Lysine	76-79	methyltransferase 21C, AARS1 lysine	Homo sapiens	28-36
32611769-6	2020	We found that METTL21C catalyzes methylation of Lys-943 of AARS1 (AARS1-K943me) both in vitro and in vivo.	Lysine	48-51	methyltransferase 21C, AARS1 lysine	Homo sapiens	14-22
32826868-4	2020	The N-terminal of VHLalpha was indispensable in mediating ubiquitination of hnRNPA2B1 at lysine residues 274 and 305.	Lysine	89-95	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	76-85
32806748-2	2020	Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a large number of genes via histone 3 methylation of lysine 27 (H3K27me3).	Lysine	222-228	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	64-91
32806748-2	2020	Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a large number of genes via histone 3 methylation of lysine 27 (H3K27me3).	Lysine	222-228	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	93-97
32747680-1	2020	Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes.	Lysine	8-14	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	34-37
32503840-2	2020	Newly discovered oncohistone mutations include lysine-to-methionine substitutions at positions 27 and 36 of histone H3.3.	Lysine	47-53	H3.3 histone B	Homo sapiens	108-120
32747680-1	2020	Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes.	Lysine	64-70	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	34-37
32747680-4	2020	Our results demonstrate that human KAT enzymes have an ability to catalyze an efficient acetylation of longer lysine analogs, whereas shorter lysine analogs are not substrates for KATs.	Lysine	110-116	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	35-38
32747680-4	2020	Our results demonstrate that human KAT enzymes have an ability to catalyze an efficient acetylation of longer lysine analogs, whereas shorter lysine analogs are not substrates for KATs.	Lysine	142-148	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	35-38
32747680-5	2020	Kinetics analyses showed that lysine is a superior KAT substrate to its analogs with altered chain length, implying that lysine has an optimal chain length for KAT-catalyzed acetylation reaction.	Lysine	30-36	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	51-54
32747680-5	2020	Kinetics analyses showed that lysine is a superior KAT substrate to its analogs with altered chain length, implying that lysine has an optimal chain length for KAT-catalyzed acetylation reaction.	Lysine	30-36	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	160-163
32747680-5	2020	Kinetics analyses showed that lysine is a superior KAT substrate to its analogs with altered chain length, implying that lysine has an optimal chain length for KAT-catalyzed acetylation reaction.	Lysine	121-127	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	51-54
32747680-5	2020	Kinetics analyses showed that lysine is a superior KAT substrate to its analogs with altered chain length, implying that lysine has an optimal chain length for KAT-catalyzed acetylation reaction.	Lysine	121-127	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	160-163
32559581-1	2020	CREB-binding protein (CBP) is a large multi-domain protein containing a HAT domain catalyzing transacetylation and a bromodomain responsible for acetylated lysine recognition.	Lysine	156-162	CREB binding protein	Homo sapiens	0-20
32559581-1	2020	CREB-binding protein (CBP) is a large multi-domain protein containing a HAT domain catalyzing transacetylation and a bromodomain responsible for acetylated lysine recognition.	Lysine	156-162	CREB binding protein	Homo sapiens	22-25
32094511-6	2020	This mechanism of degradation also required the MCL1 transmembrane domain and distinct MCL1 lysine residues to proceed, suggesting that the components likely act on the MCL1:NOXA complex by associating with it in a specific orientation within the mitochondrial outer membrane.	Lysine	92-98	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	174-178
32499570-2	2020	Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription.	Lysine	95-102	bromodomain containing 4	Homo sapiens	0-24
32499570-2	2020	Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription.	Lysine	95-102	bromodomain containing 4	Homo sapiens	26-30
32499570-8	2020	Our chromatin immunoprecipitation assay showed that JQ1 reduced the BRD4 binding to the histone H3 lysine 27 acetylation-enriched sites in the MMP2 locus.	Lysine	99-105	bromodomain containing 4	Homo sapiens	68-72
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	bromodomain containing 4	Homo sapiens	128-132
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	androgen receptor	Homo sapiens	195-197
32724079-4	2020	Acylation at lysine residues through HlyC is known to activate proHlyA into a fully functional pore-forming toxin, HlyA.	Lysine	13-19	hemolysin transport protein	Escherichia coli	37-41
32409492-3	2020	PPARgamma deacetylation on two lysine residues (K268 and K293) induces brown remodeling of white adipose tissue and uncouples TZD"s adverse effects from insulin sensitization.	Lysine	31-37	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
32747411-2	2020	The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3.	Lysine	111-117	BRCA1 associated protein 1	Homo sapiens	192-196
32747411-2	2020	The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3.	Lysine	111-117	forkhead box K1	Homo sapiens	205-212
32752130-1	2020	The eukaryotic and archaeal translation factor IF5A requires a post-translational hypusine modification, which is catalyzed by deoxyhypusine synthase (DHS) at a single lysine residue of IF5A with NAD+ and spermidine as cofactors, followed by hydroxylation to form hypusine.	Lysine	168-174	deoxyhypusine synthase	Homo sapiens	127-149
32633941-6	2020	First, the fibronectin overexpressed in the extracellular matrix (ECM) of TNBC was used as a biomarker for targeting theranostics using the Cys-Arg-Glu-Lys-Ala (CREKA) peptide.	Lysine	152-155	fibronectin 1	Homo sapiens	11-22
32723346-1	2020	Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3).	Lysine	177-180	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
32723346-1	2020	Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3).	Lysine	177-180	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
32360551-1	2020	BACKGROUND & AIMS: SETDB1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes development of several tumor types.	Lysine	88-94	SET domain, bifurcated 1	Mus musculus	19-25
32424026-0	2020	Identification of Lysine Acetylation Sites on MERS-CoV Replicase pp1ab.	Lysine	18-24	1A polyprotein;1AB polyprotein	Middle East respiratory syndrome-related coronavirus	65-70
32736564-6	2020	SIRT6 inhibition was confirmed by Western blot analysis by assessing the acetylation of histone 3 lysine 9, a known SIRT6 substrate.	Lysine	98-104	sirtuin 6	Mus musculus	0-5
32453941-0	2020	NMT as a glycine and lysine myristoyltransferase in cancer, immunity, and infections.	Lysine	21-27	N-myristoyltransferase 1	Homo sapiens	0-3
32591481-7	2020	We mapped lysine 460 in KIF4A as the SUMO acceptor site and employed CRISPR-Cas9 mediated genome editing to block SUMO conjugation of endogenous KIF4A.	Lysine	10-16	kinesin family member 4A	Homo sapiens	24-29
32698523-4	2020	We present evidence that HDAC2 binding to lamina A/C is related to HDAC2 acetylation on lysine 75 and expression of p300-CBP associated factor (PCAF), an acetyltransferase known to acetylate HDAC2.	Lysine	88-94	histone deacetylase 2	Homo sapiens	25-30
32698523-4	2020	We present evidence that HDAC2 binding to lamina A/C is related to HDAC2 acetylation on lysine 75 and expression of p300-CBP associated factor (PCAF), an acetyltransferase known to acetylate HDAC2.	Lysine	88-94	histone deacetylase 2	Homo sapiens	67-72
32698523-4	2020	We present evidence that HDAC2 binding to lamina A/C is related to HDAC2 acetylation on lysine 75 and expression of p300-CBP associated factor (PCAF), an acetyltransferase known to acetylate HDAC2.	Lysine	88-94	histone deacetylase 2	Homo sapiens	67-72
32703935-6	2020	HSD17B10 is acetylated at lysine residues K79, K99 and K105 by the acetyltransferase CBP, and the acetylation is reversed by SIRT3.	Lysine	26-32	CREB binding protein	Homo sapiens	85-88
32703935-6	2020	HSD17B10 is acetylated at lysine residues K79, K99 and K105 by the acetyltransferase CBP, and the acetylation is reversed by SIRT3.	Lysine	26-32	sirtuin 3	Homo sapiens	125-130
32764971-3	2020	The 90-kb protein methyltransferase nuclear receptor SET domain-containing 2 (NSD2) is a member of nuclear receptor SET domain-containing (NSD) protein lysine methyltransferase (KMT) family, which can cause epigenomic aberrations via altering the methylation states.	Lysine	152-158	nuclear receptor binding SET domain protein 2	Homo sapiens	36-76
32470319-3	2020	Like the chromodomains of HP1 and Polycomb, the CDY chromodomains also recognize the lysine-methylated ARKS motif embedded in histone and non-histone proteins.	Lysine	85-91	chromodomain Y-linked 1	Homo sapiens	48-51
32470319-4	2020	Interestingly, the CDY chromodomains exhibit different binding preferences for the lysine-methylated ARKS motif in different sequence contexts.	Lysine	83-89	chromodomain Y-linked 1	Homo sapiens	19-22
32567837-0	2020	Nucleosome binding by the lysine specific demethylase 1 (LSD1) enzyme enables histone H3 demethylation.	Lysine	26-32	H3 clustered histone 14	Homo sapiens	86-88
32567837-1	2020	The essential human enzyme lysine specific deme-thylase 1 (LSD1) silences genes by demethylating mono- and dimethylated lysine 4 in histone H3 (H3K4me1/2).	Lysine	27-33	H3 clustered histone 14	Homo sapiens	140-142
32567837-1	2020	The essential human enzyme lysine specific deme-thylase 1 (LSD1) silences genes by demethylating mono- and dimethylated lysine 4 in histone H3 (H3K4me1/2).	Lysine	27-33	H3 clustered histone 14	Homo sapiens	144-153
32634241-2	2020	Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on the histone methyltransferase DOT1L, which methylates histone 3 lysine 79 (H3K79).	Lysine	190-196	DOT1 like histone lysine methyltransferase	Homo sapiens	130-161
32169559-3	2020	NSD2 is a histone methyltransferase that mediates dimethylation of Histone 3 lysine 36 (H3K36me2).	Lysine	77-83	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
32764971-3	2020	The 90-kb protein methyltransferase nuclear receptor SET domain-containing 2 (NSD2) is a member of nuclear receptor SET domain-containing (NSD) protein lysine methyltransferase (KMT) family, which can cause epigenomic aberrations via altering the methylation states.	Lysine	152-158	nuclear receptor binding SET domain protein 2	Homo sapiens	78-82
32534446-0	2020	High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1alpha (HIF-1alpha) predict patients" worse prognosis in human hepatocellular carcinomas.	Lysine	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-108
32510829-2	2020	A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues.	Lysine	133-139	FA complementation group I	Homo sapiens	84-89
32573059-4	2020	Chromatin immunoprecipitation analyses further revealed that NSD2 was enriched at the gene bodies of actively transcribed genes, including cell cycle-related genes, and that loss of NSD2 decreased the levels of histone H3 lysine 36 trimethylation (H3K36me3) at these gene loci.	Lysine	222-228	nuclear receptor binding SET domain protein 2	Homo sapiens	61-65
32573059-4	2020	Chromatin immunoprecipitation analyses further revealed that NSD2 was enriched at the gene bodies of actively transcribed genes, including cell cycle-related genes, and that loss of NSD2 decreased the levels of histone H3 lysine 36 trimethylation (H3K36me3) at these gene loci.	Lysine	222-228	nuclear receptor binding SET domain protein 2	Homo sapiens	182-186
32714200-2	2020	With-no-lysine (WNK) kinase phosphorylates SPAK kinase to active the SPAK signaling pathway.	Lysine	8-14	serine/threonine kinase 39	Homo sapiens	43-47
32714200-2	2020	With-no-lysine (WNK) kinase phosphorylates SPAK kinase to active the SPAK signaling pathway.	Lysine	8-14	serine/threonine kinase 39	Homo sapiens	69-73
32534446-0	2020	High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1alpha (HIF-1alpha) predict patients" worse prognosis in human hepatocellular carcinomas.	Lysine	38-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
32534446-2	2020	In this study, we try to detect the global levels of histone lysine methylation in HCC cases and analyze the correlation between these modifications and the activation of hypoxia-inducible factor 1alpha (HIF-1alpha).	Lysine	61-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	204-214
32378752-6	2020	By binding to a component of the epigenetic modification complex enhancer of zeste homolog 2 (EZH2), ANRIL could maintain lysine residue 27 of histone 3 (H3K27me3) levels in the promoter of ERBB receptor feedback inhibitor 1 (ERRFI1), which is a tumour suppressor gene in CCA.	Lysine	122-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-92
32198816-0	2020	Yin Yang-1 suppresses CD40 ligand-CD40 signaling mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter.	Lysine	191-197	YY1 transcription factor	Homo sapiens	0-10
32187807-2	2020	The photocaged Adk is generated by substituting a catalytically essential lysine with a hydroxycoumarin-protected lysine through site-specific unnatural amino acid mutagenesis in both  E. coli  and mammalian cells.	Lysine	74-80	adenosine kinase	Homo sapiens	15-18
32187807-2	2020	The photocaged Adk is generated by substituting a catalytically essential lysine with a hydroxycoumarin-protected lysine through site-specific unnatural amino acid mutagenesis in both  E. coli  and mammalian cells.	Lysine	114-120	adenosine kinase	Homo sapiens	15-18
32187807-3	2020	Caging of the critical lysine residue offers complete suppression of Adk"s phosphotransferase activity and rapid restoration of its function both  in vitro  and  in vivo  upon optical stimulation.	Lysine	23-29	adenosine kinase	Homo sapiens	69-72
32378752-6	2020	By binding to a component of the epigenetic modification complex enhancer of zeste homolog 2 (EZH2), ANRIL could maintain lysine residue 27 of histone 3 (H3K27me3) levels in the promoter of ERBB receptor feedback inhibitor 1 (ERRFI1), which is a tumour suppressor gene in CCA.	Lysine	122-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	94-98
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Lysine	149-152	lactalbumin alpha	Homo sapiens	67-84
32445435-0	2020	ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.	Lysine	85-91	TNF receptor-associated factor 6	Mus musculus	70-75
32445435-7	2020	Mechanistically, ARRB1 directly interacts with ASK1 in hepatocytes and inhibits its TRAF6-mediated Lysine 6-linked polyubiquitination, which then prevents the activation of ASK1 and its downstream signalling pathway during hepatic I/R injury.	Lysine	99-105	TNF receptor-associated factor 6	Mus musculus	84-89
32439622-0	2020	Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology.	Lysine	80-86	transcription factor A, mitochondrial	Homo sapiens	24-60
32439622-6	2020	Mass spectrometry analysis showed that in vitro chemical acetylation of TFAM with acetyl-coenzyme A occurs preferentially on specific lysine residues, including those reported to be acetylated in exogenously expressed TFAM in cultured human cells, indicating that chemical acetylation plays a crucial role in TFAM acetylation in mitochondria.	Lysine	134-140	transcription factor A, mitochondrial	Homo sapiens	72-76
32518374-4	2020	Here, we report that lysine (K) 426 on WSTF is acetylated by MOF and deacetylated by SIRT1.	Lysine	21-27	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	39-43
32541040-5	2020	Upon oxidative insult, SUMO2 is extensively conjugated to E2F1 mainly at lysine 266 residue, which specifically modulates E2F1 transcriptional activity to enhance cell cycle arrest for cell survival.	Lysine	73-79	small ubiquitin-like modifier 2 L homeolog	Xenopus laevis	23-28
32647649-0	2020	The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1.	Lysine	12-18	BCL2 apoptosis regulator	Homo sapiens	138-143
32542505-1	2020	BACKGROUND: Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues.	Lysine	141-147	lysyl oxidase	Canis lupus familiaris	12-25
32637595-1	2020	Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary depositors of global H3K4 trimethylation (H3K4me3) in mammalian cells.	Lysine	103-109	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	10-15
32637595-1	2020	Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary depositors of global H3K4 trimethylation (H3K4me3) in mammalian cells.	Lysine	103-109	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	0-5
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	mast cell protease 1-like 1	Rattus norvegicus	49-54
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	lysine acetyltransferase 7	Rattus norvegicus	130-134
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	mast cell protease 1-like 1	Rattus norvegicus	181-186
32552847-10	2020	Mechanistically, LAMP5-AS1 facilitated the methyltransferase activity of DOT1L by directly binding its Lys-rich region of catalytic domain, thus promoting the global patterns of H3K79 dimethylation and trimethylation in cells.	Lysine	103-106	lysosomal associated membrane protein family member 5	Homo sapiens	17-22
32552847-10	2020	Mechanistically, LAMP5-AS1 facilitated the methyltransferase activity of DOT1L by directly binding its Lys-rich region of catalytic domain, thus promoting the global patterns of H3K79 dimethylation and trimethylation in cells.	Lysine	103-106	DOT1 like histone lysine methyltransferase	Homo sapiens	73-78
33173715-1	2020	Microbial rhodopsin is a large family of membrane proteins having seven transmembrane helices (TM1-7) with an all-trans retinal (ATR) chromophore that is covalently bound to Lys in the TM7.	Lysine	174-177	rhodopsin	Homo sapiens	10-19
32181984-1	2020	EP300 and CBP are two highly homologous, multidomain, epigenetic coregulators that play central roles in transcription via acetylation of lysine residues on histones and other proteins.	Lysine	138-144	CREB binding protein	Homo sapiens	10-13
32169787-4	2020	Here, we report the concomitant use of MALDI-TOF MS and LC-MS/MS analysis to investigate the chemical functionalization of human serum albumin (HSA) by the intermediate of lysine residues, previously used to generate biopharmaceutical agents for medical imaging.	Lysine	172-178	albumin	Homo sapiens	129-142
32527012-3	2020	STRAP is acetylated at lysines 147, 148, and 156 by the acetyltransferases CREB-binding protein (CBP) and that the acetylation is reversed by the deacetylase sirtuin7 (SIRT7).	Lysine	23-30	CREB binding protein	Homo sapiens	75-95
32527012-3	2020	STRAP is acetylated at lysines 147, 148, and 156 by the acetyltransferases CREB-binding protein (CBP) and that the acetylation is reversed by the deacetylase sirtuin7 (SIRT7).	Lysine	23-30	CREB binding protein	Homo sapiens	97-100
32527012-4	2020	Hypo- or hyperacetylation mutations of STRAP at lysines 147, 148, and 156 (3KR or 3KQ) influence its activation and stabilization of p53.	Lysine	48-55	tumor protein p53	Homo sapiens	133-136
32084453-3	2020	Jumonji domain-containing protein 3 (Jmjd3), a trimethylated lysine 27 in histone 3 (H3K27me3) demethylase, can be activated by nuclear factor-kappa B (NF-kappaB), further regulating the expression of pro-inflammatory cytokines and resulting in neuroinflammation.	Lysine	61-67	nuclear factor kappa B subunit 1	Homo sapiens	152-161
32496213-1	2020	The N-terminal region of the stomatin operon partner protein (STOPP) PH1510 (1510-N) from the hyperthermophilic archaeon Pyrococcus horikoshii is a serine protease with a catalytic Ser-Lys dyad (Ser97 and Lys138) and specifically cleaves the C-terminal hydrophobic region of the p-stomatin PH1511.	Lysine	185-188	stomatin	Homo sapiens	29-37
32217372-7	2020	The peptides 1-3 containing Glu-Urea-Lys and Glu-GABA-Asp as pharmacophores were efficiently interacted with crystal structure of PSMA and showed the highest binding energies range from -8 to -11.2 kcal/mol.	Lysine	37-40	folate hydrolase 1	Homo sapiens	130-134
32324084-1	2020	Ring1 and Yin Yang 1-Binding Protein (RYBP) is a member of non-canonical polycomb repressive complex 1 to mediate monoubiquitination of histone H2A at lysine 119.	Lysine	151-157	ring finger protein 1	Mus musculus	0-5
32399807-1	2020	Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFkappaB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.	Lysine	49-52	insulin like growth factor 1	Homo sapiens	105-109
32298785-4	2020	Lysine (K) 32 and K103 are major SUMOylation sites of FHY1.	Lysine	0-6	far-red elongated hypocotyl 1	Arabidopsis thaliana	54-58
32743551-5	2020	In consequence, the product of EZH2 enzymatic activity, trimethylation of histone H3 lysine 27 level, was significantly reduced.	Lysine	85-91	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
32399807-1	2020	Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFkappaB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.	Lysine	49-52	forkhead box O1	Homo sapiens	111-116
32743552-7	2020	Here, we demonstrate that Metnase is also recruited to stalled forks where it appears to dimethylate histone H3 lysine 36 (H3K36me2), raising the possibility that H3K36me2 promotes DDR factor recruitment or limits nucleosome eviction to protect forks from nucleolytic attack.	Lysine	112-118	SET domain and mariner transposase fusion gene	Homo sapiens	26-33
32457468-2	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which silences transcription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an important therapeutic target with inhibitors targeting its methyltransferase activity under clinical investigation.	Lysine	167-173	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
32494005-6	2020	We show that oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that is essential for the proper execution of HDR.	Lysine	54-60	lysine demethylase 4B	Homo sapiens	73-78
32494005-6	2020	We show that oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that is essential for the proper execution of HDR.	Lysine	129-135	lysine demethylase 4B	Homo sapiens	73-78
32457468-2	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which silences transcription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an important therapeutic target with inhibitors targeting its methyltransferase activity under clinical investigation.	Lysine	167-173	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
32486217-1	2020	SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9).	Lysine	38-44	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
32475425-5	2020	In this study, the effects of methionine and lysine, which are the 2 most limiting amino acids in the chicken diet, were supplemented in a low crude protein diet, and its effects on the growth and expression of immunity genes such as MUC2, SLC, GAL6, and LEAP-2 were studied.	Lysine	45-51	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	234-238
32475425-11	2020	Gene expression of MUC2 gene in the jejunum showed a significant increase across all experimental diets with the treatment with higher lysine in low crude protein diet with the highest increase of 3.8 times as compared with the control diet.	Lysine	135-141	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	19-23
32475425-13	2020	It was concluded that supplementation of high lysine with standard methionine in a low crude protein diet performed better in terms of lowest feed conversion ratio and high upregulation of MUC2 gene.	Lysine	46-52	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	189-193
32475447-8	2020	The mRNA abundance of mu-calpain, caspase-3, and 20S proteasome C2 subunit were increased in the Lys 90% group (P < 0.05).	Lysine	97-100	caspase 3	Gallus gallus	34-43
32400857-9	2020	The mRNA of LRP and P-gp in LY-294002 group and PDTC group were decreased.	Lysine	28-30	LDL receptor related protein 1	Homo sapiens	12-15
32486217-1	2020	SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9).	Lysine	79-85	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
32528730-6	2020	In contrast, activation of SIRT1 increased autophagy in chondrocytes by the deacetylation of lysine residues on crucial autophagy proteins (Beclin1, ATG5, ATG7, LC3).	Lysine	93-99	autophagy related 5	Homo sapiens	149-153
32332094-6	2020	We also studied the functional significance of GA-mediated lysine N-pyrrolation in proteins and found that GA-modified proteins are recognized by apolipoprotein E, a binding target of pyrrolated proteins.	Lysine	59-65	apolipoprotein E	Mus musculus	146-162
32547410-1	2020	The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle.	Lysine	35-41	titin	Mus musculus	64-69
32471461-3	2020	We here report on the histone methyltransferase Disruptor of Telomeric 1 Like (DOT1L), which mediates histone H3 lysine 79 (H3K79) methylation.	Lysine	113-119	DOT1 like histone lysine methyltransferase	Homo sapiens	79-84
32467562-4	2020	Here, we show that BCAT2 is acetylated at lysine 44 (K44), an evolutionarily conserved residue.	Lysine	42-48	branched chain amino acid transaminase 2	Homo sapiens	19-24
32460017-5	2020	Upon DC activation, JNK signaling stimulated p300 association with PKM2 for the acetylation of lysine 433, a classic posttranslational modification critical for PKM2 destabilization and nuclear re-localization.	Lysine	95-101	mitogen-activated protein kinase 8	Homo sapiens	20-23
32453962-5	2021	Mechanistically, we demonstrated that STAMBP/AMSH (STAM-binding protein) promotes the stabilization of ULK1 by removing its lysine 48 (K48)-linked ubiquitination, whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination, thus positively or negatively affects autophagy flux, respectively.	Lysine	124-130	STAM binding protein	Homo sapiens	38-44
32453962-5	2021	Mechanistically, we demonstrated that STAMBP/AMSH (STAM-binding protein) promotes the stabilization of ULK1 by removing its lysine 48 (K48)-linked ubiquitination, whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination, thus positively or negatively affects autophagy flux, respectively.	Lysine	124-130	STAM binding protein	Homo sapiens	45-49
32453962-5	2021	Mechanistically, we demonstrated that STAMBP/AMSH (STAM-binding protein) promotes the stabilization of ULK1 by removing its lysine 48 (K48)-linked ubiquitination, whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination, thus positively or negatively affects autophagy flux, respectively.	Lysine	124-130	STAM binding protein	Homo sapiens	51-71
32466590-1	2020	The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells.	Lysine	39-45	BRCA1 associated protein 1	Homo sapiens	67-71
32508971-1	2020	Background: The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repressor and is an epigenetic regulator for several cancers.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	16-43
32508971-1	2020	Background: The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repressor and is an epigenetic regulator for several cancers.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	45-49
32508971-1	2020	Background: The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repressor and is an epigenetic regulator for several cancers.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	183-187
32448308-2	2020	As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transcription mainly by catalyzing the trimethylation of histone H3 at lysine 27 (H3K27me3) and exerts highly enzymatic activity in cancer cells.	Lysine	158-164	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	36-63
32448279-10	2020	Further mechanistic studies revealed that EZH2 mediated trimethylation of lysine 27 on histone H3 of the KAT6B promoter.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	42-46
32450905-3	2020	Disruptor of telomeric silencing, hDot1L is the only non-SET domain containing histone methyltransferase that methylates histone H3 at lysine 79.	Lysine	135-141	DOT1 like histone lysine methyltransferase	Homo sapiens	34-40
32448308-2	2020	As the master epigenetic regulator, enhancer of zeste homolog 2 (EZH2) suppresses gene transcription mainly by catalyzing the trimethylation of histone H3 at lysine 27 (H3K27me3) and exerts highly enzymatic activity in cancer cells.	Lysine	158-164	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
32453339-3	2020	In this study, we found that the enhancer of zeste homolog 2 (EZH2), which catalyzes the methylation at lysine 27 of histone H3, is a target of USP7 and is stabilized by USP7-mediated deubiquitination.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-60
32243810-4	2020	We show that IFITM3 ubiquitination at lysine 24 is crucial for VCP binding, trafficking, turnover, and engagement with incoming virus particles.	Lysine	38-44	interferon induced transmembrane protein 3	Homo sapiens	13-19
32444594-1	2020	The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear.	Lysine	4-10	kynurenine aminotransferase 3	Mus musculus	38-42
32250101-1	2020	Herein, conjugation of the amyloid-beta (Abeta) peptide fragment, Lys-Leu-Val-Phe-Phe (KLVFF, fragment of Abeta16-20) with an unsymmetrical near-infrared (NIR) cyanine-5 (Cy-5) chromophore is achieved using microwave assisted solid phase synthesis on 2-chlorotrityl chloride resin.	Lysine	66-69	amyloid beta precursor protein	Homo sapiens	41-46
32453339-3	2020	In this study, we found that the enhancer of zeste homolog 2 (EZH2), which catalyzes the methylation at lysine 27 of histone H3, is a target of USP7 and is stabilized by USP7-mediated deubiquitination.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	62-66
32477007-11	2020	EZH2-mediated histone 3 trimethylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation, at the FOSB promoter inhibited it expression.	Lysine	41-47	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
32930261-7	2020	Furthermore, the observed ApoB and lysine changes indicated that lysine was largely incorporated into ApoB particles during the disease process.	Lysine	65-71	apolipoprotein B	Rattus norvegicus	26-30
32424115-6	2020	Our results reveal a juxtaposed bipartite electrostatic interaction utilized by the nucleosome to direct RNF168 orientation towards the target lysine residues in proximity to the H2A alpha1-extension helix, which plays an important role in the DDR pathway.	Lysine	143-149	BCL2 related protein A1	Homo sapiens	183-189
32930261-7	2020	Furthermore, the observed ApoB and lysine changes indicated that lysine was largely incorporated into ApoB particles during the disease process.	Lysine	65-71	apolipoprotein B	Rattus norvegicus	102-106
32173363-1	2020	Transcriptional coactivators p300 and CBP catalyze the acetylation of lysine residues in histone proteins.	Lysine	70-76	CREB binding protein	Homo sapiens	38-41
32440219-2	2020	WD repeat domain 5 (WDR5) belongs to the components of the lysine methyltransferase complex.	Lysine	59-65	WD repeat domain 5	Homo sapiens	0-18
32440219-2	2020	WD repeat domain 5 (WDR5) belongs to the components of the lysine methyltransferase complex.	Lysine	59-65	WD repeat domain 5	Homo sapiens	20-24
32314924-1	2020	Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating gene transcription.	Lysine	75-81	CREB binding protein	Homo sapiens	53-56
32249212-0	2020	SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation.	Lysine	49-52	protein inhibitor of activated STAT 2	Homo sapiens	82-87
32213532-8	2020	Finally, upregulation of the distal Adh transcript led to the enrichment of histone 3 lysine 36 trimethylation over the Adh proximal promoter.	Lysine	86-92	Alcohol dehydrogenase	Drosophila melanogaster	36-39
31987833-0	2020	l-lysine confers neuroprotection by suppressing inflammatory response via microRNA-575/PTEN signaling after mouse intracerebral hemorrhage injury.	Lysine	0-8	phosphatase and tensin homolog	Mus musculus	87-91
31987833-7	2020	Consistent with the role of PTEN in regulating inflammatory response, we find that PTEN inhibition promotes M2 microglial polarization and suppresses pro-inflammatory response in mouse ICH injury, which contribute to the neuroprotective effect of l-lysine.	Lysine	247-255	phosphatase and tensin homolog	Mus musculus	28-32
31987833-7	2020	Consistent with the role of PTEN in regulating inflammatory response, we find that PTEN inhibition promotes M2 microglial polarization and suppresses pro-inflammatory response in mouse ICH injury, which contribute to the neuroprotective effect of l-lysine.	Lysine	247-255	phosphatase and tensin homolog	Mus musculus	83-87
31987833-8	2020	Moreover, our results reveal that microRNA-575 directly suppressed PTEN to promote M2 microglial polarization and mediate the neuroprotective effect of l-lysine in ICH injury.	Lysine	152-160	phosphatase and tensin homolog	Mus musculus	67-71
31987833-9	2020	Together, our results suggest that l-lysine confers neuroprotection after ICH injury through enhancing M2 microglial polarization and reducing inflammatory response, which is mediated by microRNA-575 upregulation and subsequent PTEN downregulation.	Lysine	35-43	phosphatase and tensin homolog	Mus musculus	228-232
31883159-4	2020	Both SWI3B and HDA6 maintain transposon silencing by decreasing histone H3 lysine 9 acetylation, but increasing histone H3 lysine 9 di-methylation, DNA methylation and nucleosome occupancy.	Lysine	75-81	switch subunit 3	Arabidopsis thaliana	5-10
32338270-0	2020	Lysine inhibits apoptosis in satellite cells to govern skeletal muscle growth via the JAK2-STAT3 pathway.	Lysine	0-6	signal transducer and activator of transcription 3	Homo sapiens	91-96
32338270-6	2020	Interestingly, apoptosis was suppressed, and the JAK2-STAT3 pathway was reactivated after Lys re-supplementation.	Lysine	90-93	signal transducer and activator of transcription 3	Homo sapiens	54-59
32338270-8	2020	Moreover, the JAK2-STAT3 pathway was reactivated by Lys re-supplementation and suppressed cell apoptosis, and this effect was inhibited after treatment with Tyrphostin B42 (AG 490).	Lysine	52-55	signal transducer and activator of transcription 3	Homo sapiens	19-24
32338270-9	2020	In conclusion, we found that Lys inhibits apoptosis in SCs to govern skeletal muscle growth via the JAK2-STAT3 pathway.	Lysine	29-32	signal transducer and activator of transcription 3	Homo sapiens	105-110
32227584-5	2020	Further analysis of epigenetic changes in CF revealed that overexpressed PI16 decreases the nuclear level of histone deacetylase 1 (HDAC1) after angiotensin II treatment, resulting in increased histone 3 acetylation in K18 and K27 lysine.	Lysine	231-237	peptidase inhibitor 16	Mus musculus	73-77
32205424-5	2020	Further, using a myeloid-specific mixed-lineage leukemia 1 (MLL1) knockout (Mll1f/fLyz2Cre+ ), we determined that MLL1 drives Tlr4 expression in diabetic macrophages by regulating levels of histone H3 lysine 4 trimethylation on the Tlr4 promoter.	Lysine	201-207	toll-like receptor 4	Mus musculus	126-130
32323799-10	2020	PLCepsilon depletion also increased the presence of histone H3 lysine 27 trimethylation in the PARP1 promoter region, suggesting increased methylation of the PARP1 gene and thus resulting in reduced expression of PARP1.	Lysine	63-69	poly(ADP-ribose) polymerase 1	Homo sapiens	95-100
31883159-4	2020	Both SWI3B and HDA6 maintain transposon silencing by decreasing histone H3 lysine 9 acetylation, but increasing histone H3 lysine 9 di-methylation, DNA methylation and nucleosome occupancy.	Lysine	123-129	switch subunit 3	Arabidopsis thaliana	5-10
32346159-2	2021	Heterozygous variants of SETD1A involved in histone H3 lysine 4 (H3K4) methylation were previously identified in individuals with schizophrenia.	Lysine	55-61	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	25-31
32088946-6	2020	The largest difference between eukaryotic and prokaryotic IleRS enzymes is closure of the active site pocket by Phe55 in the HIGH loop; Arg410 in the CP core loop; and the second Lys in the KMSKR loop.	Lysine	179-182	isoleucyl-tRNA synthetase 1	Homo sapiens	58-63
32373130-8	2020	The chromatin immunoprecipitation assay showed that IFNgamma stimulation increased the acetylation of histone H3 lysine 27, which is important for conversion to euchromatin, as well as the trimethylation of histone H3 lysine 4 levels in the CIITA promoter IV (p-IV) region, but both were suppressed in the group stimulated with IFNgamma after rM180 treatment.	Lysine	113-119	interferon gamma	Mus musculus	52-60
32354117-6	2020	USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival.	Lysine	127-133	nuclear factor kappa B subunit 1	Homo sapiens	69-78
32341358-3	2020	Here we show that RNF40, a histone H2B lysine 120 E3 ubiquitin-protein ligase, is specifically required for early reprogramming during induced pluripotency.	Lysine	39-45	ring finger protein 40	Homo sapiens	18-23
32324495-3	2020	The BETs (bromodomain and extraterminal-containing protein family), which includes BRD2, BRD3, and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetylated lysine residues on histone tails where they facilitate the assembly of transcription complexes including transcription factors and transcriptional machinery like RNA Polymerase II.	Lysine	200-206	bromodomain containing 4	Homo sapiens	99-103
32373130-8	2020	The chromatin immunoprecipitation assay showed that IFNgamma stimulation increased the acetylation of histone H3 lysine 27, which is important for conversion to euchromatin, as well as the trimethylation of histone H3 lysine 4 levels in the CIITA promoter IV (p-IV) region, but both were suppressed in the group stimulated with IFNgamma after rM180 treatment.	Lysine	218-224	interferon gamma	Mus musculus	52-60
32112098-3	2020	MORC2 is acetylated by the acetyltransferase NAT10 at lysine 767 (K767Ac) and this process is counteracted by the deacetylase SIRT2 under unperturbed conditions.	Lysine	54-60	N-acetyltransferase 10	Homo sapiens	45-50
32317327-0	2020	X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5" Long Terminal Repeat of HIV Proviral DNA.	Lysine	125-131	CD4 molecule	Homo sapiens	64-67
31891777-5	2020	We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites, some of which are removed by HDA9, resulting in inhibition of WRKY53 transcription activity.	Lysine	57-63	histone deacetylase 9	Arabidopsis thaliana	124-128
32061389-2	2020	Lysine acetylation is required to mediate activation of p53.	Lysine	0-6	tumor protein p53	Homo sapiens	56-59
32061389-6	2020	We found that not all lysine residues are equally capable of promoting p53"s functions.	Lysine	22-28	tumor protein p53	Homo sapiens	71-74
32207962-1	2020	The residue lysine 28 (K28) is known to form an important salt bridge to stabilize the Abeta amyloid structure, and acetylation of lysine 28 (K28) only slows down Abeta42 fibrillization rate but does not affect fibril morphology.	Lysine	12-18	keratin 28	Homo sapiens	23-26
32207962-1	2020	The residue lysine 28 (K28) is known to form an important salt bridge to stabilize the Abeta amyloid structure, and acetylation of lysine 28 (K28) only slows down Abeta42 fibrillization rate but does not affect fibril morphology.	Lysine	131-137	keratin 28	Homo sapiens	142-145
32326637-4	2020	Several reported CaM interactors lack these anchors but contain Lys/Arg-rich polybasic sequences adjacent to a lipidated N- or C-terminus.	Lysine	64-67	calmodulin 1	Homo sapiens	17-20
32175624-5	2020	Importantly, proteasome inhibition led to the accumulation of TDP-43 ubiquitinated within the nuclear localization signal (NLS) at lysine 95.	Lysine	131-137	TAR DNA binding protein	Homo sapiens	62-68
32195489-4	2020	Immunoprecipitation assay and Western blot analysis indicated that phloretin could decrease the lysine acetylation of MnSOD and restore its activity by promoting the expression of Sirt3 by increasing the phosphorylation of AMPK (Thr172).	Lysine	96-102	superoxide dismutase 2, mitochondrial	Mus musculus	118-123
32238799-6	2020	Further, we found that ubiquitin ligase HUWE1 induced the K27-/K29-linked noncanonical ubiquitination of JMJD1A at lysine-918.	Lysine	115-121	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	40-45
32235597-5	2020	Inhibiting ubiquitination by mutating all of the A3H lysines increased the expression of haplotypes III and IV, but these stabilized forms of haplotype III and IV had a strict nuclear localization, and did not incorporate into virions, nor exhibit antiviral activity.	Lysine	53-60	apolipoprotein B mRNA editing enzyme catalytic subunit 3H	Homo sapiens	49-52
32071397-1	2020	The ubiquitously transcribed tetratricopeptide repeat on X chromosome (UTX) is a major histone H3 lysine 27 (H3K27) demethylase and the mixed-lineage leukemia (MLL) proteins are the H3K4 methyltransferases.	Lysine	98-104	lysine demethylase 6A	Homo sapiens	71-74
32122997-4	2020	Peptide scan analyses led to the discovery of a peptide containing methyl lysines recognized by a mAb that binds to native HBHA ~100-fold better than to rHBHA-Ms This peptide was also recognized by T cells from latently infected humans, as evidenced by IFN-gamma release upon peptide stimulation.	Lysine	74-81	interferon gamma	Homo sapiens	253-262
32296174-2	2020	Here we report that deficiency in SETDB1, a histone methyltransferase that mediates the trimethylation of histone H3 at lysine 9, participates in the pathogenesis of IBD.	Lysine	120-126	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	34-40
32244385-3	2020	The upregulated expression of disruptor of telomeric silencing 1-like (DOT1L), a histone methyltransferase specific for the histone H3 lysine 79 residue (H3K79), is strongly correlated with TNBC cell aggressiveness.	Lysine	135-141	DOT1 like histone lysine methyltransferase	Homo sapiens	71-76
32235505-2	2020	DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine spermidine to a specific lysine of eukaryotic translation factor 5A (eIF5A) precursor in a nicotinamide adenine dinucleotide (NAD)-dependent manner.	Lysine	90-96	deoxyhypusine synthase	Homo sapiens	0-3
32215184-1	2020	The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of MLL-rearranged leukemia.	Lysine	14-20	DOT1 like histone lysine methyltransferase	Homo sapiens	56-61
32097010-2	2020	The most promising PSMA-targeted agents in the clinical phase are based on the Lys-urea-Glu motif, in which Lys and Glu are alpha-(l)-amino acids.	Lysine	79-82	folate hydrolase 1	Homo sapiens	19-23
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	small ubiquitin-like modifier 1	Mus musculus	84-115
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	small ubiquitin-like modifier 1	Mus musculus	117-122
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	small ubiquitin-like modifier 2	Mus musculus	128-135
32244917-3	2020	Here, we showed a redox-dependent destabilization induced in human cytochrome c by substituting Phe82-conserved amino acid and a key actor in cytochrome c intermolecular interactions-with a Lys residue.	Lysine	190-193	cytochrome c, somatic	Homo sapiens	67-79
32244917-3	2020	Here, we showed a redox-dependent destabilization induced in human cytochrome c by substituting Phe82-conserved amino acid and a key actor in cytochrome c intermolecular interactions-with a Lys residue.	Lysine	190-193	cytochrome c, somatic	Homo sapiens	142-154
32081062-12	2020	Lys (K) 63-linked ubiquitination modulated by Ube2v1 expression enhanced protein aggregation and contributed to Ube2v1"s function in regulating protein aggregate formation.	Lysine	0-3	ubiquitin conjugating enzyme E2 V1	Rattus norvegicus	46-52
32081062-12	2020	Lys (K) 63-linked ubiquitination modulated by Ube2v1 expression enhanced protein aggregation and contributed to Ube2v1"s function in regulating protein aggregate formation.	Lysine	0-3	ubiquitin conjugating enzyme E2 V1	Rattus norvegicus	112-118
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Lysine	151-154	coagulation factor II, thrombin	Homo sapiens	12-20
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Lysine	151-154	coagulation factor II, thrombin	Homo sapiens	93-101
32265653-4	2020	First, mutational analysis of CD4-MX-helix chimeric proteins showed that the Golgi retention signal was dependent on both the amphipathic nature of the MX-helix and on specific lysine residues (betaK353 and deltaK351).	Lysine	177-183	CD4 molecule	Homo sapiens	30-33
31935506-2	2020	Studies have determined that pathogenic variants of the lysine-specific methyltransferase 2D (KMT2D) and lysine-specific demethylase 6A (KDM6A) genes are the major causes of KS.	Lysine	56-62	lysine demethylase 6A	Homo sapiens	137-142
31846690-7	2020	A set of 10 lysine residues on human serum albumin are labeled by tabun derivatives in vitro, with K525 (K*QTALVELVK) and K199 (LK*CASLQK) peptides displaying the most reactivity.	Lysine	12-18	albumin	Homo sapiens	37-50
32176739-4	2020	Here, we report that EBNA1 contains two SUMO-interacting motifs (SIM2 and SIM3), and mutation of SIM2, but not SIM3, dramatically disrupts the EBNA1 dimerization, while SIM3 contributes to the polySUMO2 modification of EBNA1 at lysine 477 in vitro.	Lysine	228-234	EBNA-1	Human gammaherpesvirus 4	21-26
31846690-10	2020	Molecular simulation of the tabun-albumin interaction using structural analysis and molecular docking provided theoretical evidence supporting lysine residue reactivity to phosphonylation by tabun derivatives.	Lysine	143-149	albumin	Homo sapiens	34-41
32183142-2	2020	The structure-activity relationship of branched H-Lys(hArg)-Dab-Dhp-Arg-OH sequence analogues, modified with Cys-Asp or Cys at N-terminal amino acids (Lys, hArg), in VEGF-A165/Neuropilin-1 complex inhibition is presented.	Lysine	50-53	dihydropyrimidinase	Homo sapiens	64-67
31948749-4	2020	In addition, we observed that WDR5 promoted the binding of Myc to CARM1 promoter by interacting with Myc and inducing histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	128-134	WD repeat domain 5	Homo sapiens	30-34
32024693-6	2020	ChIP results indicated increased enrichment of histone 3 at lysine 9 dimethylation, a G9a-catalyzed repressive histone mark, at the promoter regions of the CB1R genes.	Lysine	60-66	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	86-89
32219097-8	2020	Interestingly, oral administration of seven essential amino acids (EAAs; valine, leucine, isoleucine, lysine, phenylalanine, histidine, and tryptophan) to LPD mice, which can be a source of neurotransmitters, reversed those behavioral changes.	Lysine	102-108	acyl-CoA synthetase bubblegum family member 1	Mus musculus	155-158
32292498-15	2020	Increased levels of SIRT1 reduced nuclear factor kappaB (NF-kappaB) activity by decreasing the level of acetylation of Lysine 310, as well as inhibiting tumor necrosis factor-alpha (Tnf-alpha) and interleukin 1 (IL-1) expressions.	Lysine	119-125	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
32182705-0	2020	Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation.	Lysine	46-52	fibronectin 1	Homo sapiens	15-26
31875226-5	2020	STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha1, the beta1-beta2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha2 bind to the phosphodiester backbone from the major groove side.	Lysine	195-202	BCL2 related protein A1	Homo sapiens	132-137
31512982-5	2020	We found a parallel increase in the acetylation of lysines 9 and 14 of H3 in induced genes during stress, which was largely dependent on Hog1 at the genome-wide level.	Lysine	51-58	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	137-141
31811908-4	2020	Acetylation of AFP at lysines 194, 211, and 242 increased the stability of AFP protein by decreasing its ubiquitination and proteasomal degradation.	Lysine	22-29	alpha fetoprotein	Homo sapiens	15-18
31811908-4	2020	Acetylation of AFP at lysines 194, 211, and 242 increased the stability of AFP protein by decreasing its ubiquitination and proteasomal degradation.	Lysine	22-29	alpha fetoprotein	Homo sapiens	75-78
31875226-5	2020	STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha1, the beta1-beta2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha2 bind to the phosphodiester backbone from the major groove side.	Lysine	195-202	BCL2 related protein A1	Homo sapiens	120-126
31482666-1	2020	A reengineered human cellular retinol binding protein II (hCRBPII), a 15-kDa protein belonging to the intracellular lipid binding protein (iLBP) family, generates a highly fluorescent red pigment through the covalent linkage of a merocyanine aldehyde to an active site lysine residue.	Lysine	269-275	retinol binding protein 2	Homo sapiens	21-56
31482666-1	2020	A reengineered human cellular retinol binding protein II (hCRBPII), a 15-kDa protein belonging to the intracellular lipid binding protein (iLBP) family, generates a highly fluorescent red pigment through the covalent linkage of a merocyanine aldehyde to an active site lysine residue.	Lysine	269-275	retinol binding protein 2	Homo sapiens	58-65
31531877-8	2020	CBP immediately evoked KDM2B acetylation at lysine residue 765 in colon cancer cells.	Lysine	44-50	CREB binding protein	Homo sapiens	0-3
31873223-6	2020	Consequently, a basic triad unique to UBE2T engages a structured acidic patch near the target lysine on FANCD2.	Lysine	94-100	ubiquitin conjugating enzyme E2 T	Homo sapiens	38-43
32184802-9	2020	PLOD1 and SETD7 genes were involved with lysine degradation in low feed efficient group in Landrace, while high feed efficient group pointed to genes underpinning valine, leucine, isoleucine degradation, and fatty acid elongation.	Lysine	41-47	SET domain containing 7, histone lysine methyltransferase	Sus scrofa	10-15
32111831-0	2020	High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.	Lysine	112-115	N-myristoyltransferase 1	Homo sapiens	35-57
31875226-5	2020	STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha1, the beta1-beta2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha2 bind to the phosphodiester backbone from the major groove side.	Lysine	195-202	glycoprotein hormone subunit alpha 2	Homo sapiens	138-143
32111831-4	2020	We demonstrate that this mechanism further supports efficient and unprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase.	Lysine	112-118	N-myristoyltransferase 1	Homo sapiens	155-158
31875226-5	2020	STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha1, the beta1-beta2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha2 bind to the phosphodiester backbone from the major groove side.	Lysine	195-202	glycoprotein hormone subunit alpha 2	Homo sapiens	212-218
32120841-5	2020	In the present study, we identified the specific NTD of RORalpha2 that enhances prostate tumor progression and proliferation via lysine methylation-mediated recruitment of coactivator complex pontin/Tip60.	Lysine	129-135	RuvB like AAA ATPase 1	Homo sapiens	192-198
32101556-2	2020	A peptide from C-terminus of interferon alpha1, conjugated to palmitoyl-lysine for cell penetration, denoted as IFNalpha-C, was tested for its anti-inflammatory properties in ARPE-19 cells, followed by testing in a mouse model of EAU.	Lysine	72-78	interferon alpha 1	Homo sapiens	29-46
32016207-1	2020	Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits gamma-secretase production of amyloid-beta with muM IC50.	Lysine	125-132	amyloid beta precursor protein	Homo sapiens	168-193
32101556-2	2020	A peptide from C-terminus of interferon alpha1, conjugated to palmitoyl-lysine for cell penetration, denoted as IFNalpha-C, was tested for its anti-inflammatory properties in ARPE-19 cells, followed by testing in a mouse model of EAU.	Lysine	72-78	interferon alpha 10	Homo sapiens	112-122
32103017-2	2020	Unexpectedly, we find that human N-terminal glycine myristoyltransferases (NMT) 1 and 2 can efficiently myristoylate specific lysine residues.	Lysine	126-132	N-myristoyltransferase 1	Homo sapiens	33-87
31636385-2	2020	Overexpression of enhancer of zeste homolog 2 (EZH2), the major histone H3 lysine 27 methyltransferase, has been connected to prostate cancer malignancy.	Lysine	75-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	18-45
32093281-7	2020	Additionally, the protein stability and transcriptional activity of p53 in TFAM knockdown tumor cells was attenuated, and this was associated with decreased acetylation, especially the acetylation of lysine 382 of p53.	Lysine	200-206	tumor protein p53	Homo sapiens	68-71
32093281-7	2020	Additionally, the protein stability and transcriptional activity of p53 in TFAM knockdown tumor cells was attenuated, and this was associated with decreased acetylation, especially the acetylation of lysine 382 of p53.	Lysine	200-206	transcription factor A, mitochondrial	Homo sapiens	75-79
32093281-7	2020	Additionally, the protein stability and transcriptional activity of p53 in TFAM knockdown tumor cells was attenuated, and this was associated with decreased acetylation, especially the acetylation of lysine 382 of p53.	Lysine	200-206	tumor protein p53	Homo sapiens	214-217
31732298-5	2020	Notably, miR24-2 inhibits histone deacetylase HDAC3 through miR675, which promotes the acetylation of histone H4 at lysine 16.	Lysine	116-122	microRNA 675	Homo sapiens	60-66
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	ubiquitin specific peptidase 13	Homo sapiens	114-144
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	ubiquitin specific peptidase 13	Homo sapiens	146-151
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	ubiquitin specific peptidase 13	Homo sapiens	172-177
32140850-1	2020	BACKGROUND: The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells.	Lysine	72-75	folate hydrolase 1	Homo sapiens	116-150
32140850-1	2020	BACKGROUND: The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells.	Lysine	72-75	folate hydrolase 1	Homo sapiens	95-99
32078691-5	2020	The most frequent mutation in DIPG is a lysine to methionine (K27M) mutation that occurs on H3F3A and HIST1H3B/C, genes encoding histone variants.	Lysine	40-46	H3 clustered histone 2	Homo sapiens	102-110
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	lysophosphatidic acid receptor 6	Mus musculus	145-150
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	lysophosphatidic acid receptor 6	Mus musculus	237-242
31408253-2	2020	The histone mark histone 3 lysine 4 acetylation (H3K4Ac) is observed in the promoter regions of various EMT marker genes (eg, CDH1 and VIM).	Lysine	27-33	cadherin 1	Homo sapiens	126-130
31636385-2	2020	Overexpression of enhancer of zeste homolog 2 (EZH2), the major histone H3 lysine 27 methyltransferase, has been connected to prostate cancer malignancy.	Lysine	75-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	47-51
31271662-2	2020	Here we focused on the catalytic Jumonji domain of histone H3 lysine 9 (H3K9) demethylase JMJD1C to screen for potential small molecular modulators from 149,519 natural products and 33,765 Chinese medicine components via virtual screening.	Lysine	62-68	jumonji domain containing 1C	Homo sapiens	90-96
32206572-9	2020	Besides pathogenic variants of BAP1, rare missense variants were found in genes encoding lysine-specific histone methyltransferase SETD2 and SETDB1 and genes encoding subunits of the mSWI/SNF chromatin remodeling complex.	Lysine	89-95	BRCA1 associated protein 1	Homo sapiens	31-35
31830521-9	2020	By further mechanistic analysis, we demonstrated that knockdown of LSD1 prevented fibroblast--to-myofibroblast differentiation and subsequent pulmonary fibrosis by suppressing TGF-beta1/Smad3 signaling pathway through modulation of a balance between histone H3 lysine 9 methylation and histone H3 lysine 4 methylation.	Lysine	261-267	lysine (K)-specific demethylase 1A	Mus musculus	67-71
31830521-9	2020	By further mechanistic analysis, we demonstrated that knockdown of LSD1 prevented fibroblast--to-myofibroblast differentiation and subsequent pulmonary fibrosis by suppressing TGF-beta1/Smad3 signaling pathway through modulation of a balance between histone H3 lysine 9 methylation and histone H3 lysine 4 methylation.	Lysine	297-303	lysine (K)-specific demethylase 1A	Mus musculus	67-71
32206572-9	2020	Besides pathogenic variants of BAP1, rare missense variants were found in genes encoding lysine-specific histone methyltransferase SETD2 and SETDB1 and genes encoding subunits of the mSWI/SNF chromatin remodeling complex.	Lysine	89-95	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	141-147
31535851-10	2020	Adduct formation with different hepatic and plasma proteins was investigated by LC-MS/MS and adducts between pazopanib or sunitinib aldehyde derivatives and lysine residues on both CYP3A4 and plasma proteins were indeed shown for the first time.	Lysine	157-163	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187
31664507-5	2020	Furthermore, the hydrogen bonding between the interfacial oxygen atoms of CeO2 and lysine residues of the cytochrome c in bacteria yields excellent extracellular electron transfer efficiency.	Lysine	83-89	cytochrome c, somatic	Homo sapiens	106-118
31744885-9	2020	Mechanistically, SIRT6 bound to and repressed the expression of key TGF-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone 3.	Lysine	143-146	sirtuin 6	Mus musculus	17-22
31744885-9	2020	Mechanistically, SIRT6 bound to and repressed the expression of key TGF-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone 3.	Lysine	153-156	sirtuin 6	Mus musculus	17-22
31792055-0	2020	High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor-related protein 1 requires lysines 80, 88, and 207.	Lysine	112-119	LDL receptor related protein 1	Homo sapiens	72-102
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	plasminogen activator, urokinase	Homo sapiens	133-136
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	LDL receptor related protein 1	Homo sapiens	158-162
31792055-9	2020	Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.	Lysine	155-158	LDL receptor related protein 1	Homo sapiens	48-52
31792055-9	2020	Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.	Lysine	155-158	plasminogen activator, urokinase	Homo sapiens	273-276
31909745-2	2020	TRX from the extremely halophilic archaeon Halobacterium salinarum NRC-1 (HsTRX-A), which has the highest acidic residue content [(Asp + Glu)/(Arg + Lys + His) = 9.0] among known TRXs, was chosen to elucidate the catalytic mechanism and evolutionary characteristics associated with haloadaptation.	Lysine	149-152	thioredoxin family protein	Halobacterium salinarum NRC-1	0-3
31678591-2	2020	Although lysine residue at 72 (K72) of Cyt c plays an important role in the Cyt c-Apaf-1 interaction, the underlying mechanism of interaction between Cyt c and Apaf-1 is still not clearly defined.	Lysine	9-15	cytochrome c, somatic	Homo sapiens	39-44
31678591-2	2020	Although lysine residue at 72 (K72) of Cyt c plays an important role in the Cyt c-Apaf-1 interaction, the underlying mechanism of interaction between Cyt c and Apaf-1 is still not clearly defined.	Lysine	9-15	cytochrome c, somatic	Homo sapiens	76-81
31678591-2	2020	Although lysine residue at 72 (K72) of Cyt c plays an important role in the Cyt c-Apaf-1 interaction, the underlying mechanism of interaction between Cyt c and Apaf-1 is still not clearly defined.	Lysine	9-15	apoptotic peptidase activating factor 1	Homo sapiens	82-88
31678591-2	2020	Although lysine residue at 72 (K72) of Cyt c plays an important role in the Cyt c-Apaf-1 interaction, the underlying mechanism of interaction between Cyt c and Apaf-1 is still not clearly defined.	Lysine	9-15	cytochrome c, somatic	Homo sapiens	76-81
31678591-3	2020	Here we identified multiple lysine residues including K72, which are also known to interact with ATP, to play a key role in Cyt c-Apaf-1 interaction.	Lysine	28-34	cytochrome c, somatic	Homo sapiens	124-129
31678591-3	2020	Here we identified multiple lysine residues including K72, which are also known to interact with ATP, to play a key role in Cyt c-Apaf-1 interaction.	Lysine	28-34	apoptotic peptidase activating factor 1	Homo sapiens	130-136
31678591-11	2020	These findings suggest important role for lysine residues of Cyt c and nucleotides in the regulation of apoptosome-dependent apoptotic cell death as well as demonstrate how these mutations and nucleotides may have a pivotal role in human diseases such as cancer.	Lysine	42-48	cytochrome c, somatic	Homo sapiens	61-66
31914665-1	2020	A glutamic acid to lysine (E40K) residue substitution in superoxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic lateral sclerosis (ALS).	Lysine	19-25	superoxide dismutase 1	Canis lupus familiaris	57-79
31370726-0	2020	Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif.	Lysine	62-68	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	25-30
32305562-10	2020	Moreover, our molecular data further demonstrated that Sirt6 deacetylates Smad3 at key lysine residues K333 and K378 and attenuates its transcriptional activity induced by TGFbeta in the hepatic stellate cells.	Lysine	87-93	sirtuin 6	Mus musculus	55-60
31914665-1	2020	A glutamic acid to lysine (E40K) residue substitution in superoxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic lateral sclerosis (ALS).	Lysine	19-25	superoxide dismutase 1	Canis lupus familiaris	81-85
31713888-1	2020	The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins.	Lysine	130-136	CREB binding protein	Homo sapiens	4-24
31222801-0	2020	Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.	Lysine	102-108	TNF receptor-associated factor 6	Mus musculus	11-43
31222801-5	2020	Here, we further demonstrated that tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes lysine 6 (Lys6)-linked polyubiquitination and subsequent activation of ASK1 to trigger the release of robust proinflammatory and profibrotic factors in hepatocytes, which, in turn, drive HSC activation and hepatic fibrosis.	Lysine	103-109	TNF receptor-associated factor 6	Mus musculus	35-85
31222801-5	2020	Here, we further demonstrated that tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes lysine 6 (Lys6)-linked polyubiquitination and subsequent activation of ASK1 to trigger the release of robust proinflammatory and profibrotic factors in hepatocytes, which, in turn, drive HSC activation and hepatic fibrosis.	Lysine	103-109	TNF receptor-associated factor 6	Mus musculus	87-92
31407364-1	2020	SET domain-containing protein 2 (SETD2), the protein of regulating trimethylation status of histone H3 at lysine 36 (H3K36), participates in the maintenance of chromatin architecture, transcription elongation, genome stability, and other biological events.	Lysine	106-112	SET domain containing 2	Mus musculus	0-31
31407364-1	2020	SET domain-containing protein 2 (SETD2), the protein of regulating trimethylation status of histone H3 at lysine 36 (H3K36), participates in the maintenance of chromatin architecture, transcription elongation, genome stability, and other biological events.	Lysine	106-112	SET domain containing 2	Mus musculus	33-38
31201358-3	2020	Here, we report that histone 3 lysine 27 demethylase KDM6A (UTX) is targeted by inactivating mutations and mutation-independent regulation in relapsed AML.	Lysine	31-37	lysine demethylase 6A	Homo sapiens	53-58
31201358-3	2020	Here, we report that histone 3 lysine 27 demethylase KDM6A (UTX) is targeted by inactivating mutations and mutation-independent regulation in relapsed AML.	Lysine	31-37	lysine demethylase 6A	Homo sapiens	60-63
31713888-1	2020	The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins.	Lysine	130-136	CREB binding protein	Homo sapiens	26-29
32008421-0	2020	Patent spotlight: small-molecule lysine acetyltransferase inhibitors (KATi).	Lysine	33-39	kynurenine aminotransferase 1	Homo sapiens	70-74
31462706-1	2020	Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function.	Lysine	19-25	lysyl oxidase like 2	Homo sapiens	40-60
31462706-1	2020	Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function.	Lysine	19-25	lysyl oxidase like 2	Homo sapiens	62-67
31576013-7	2020	Further investigation revealed that SIRT1 deacetylates and stabilizes GLI2 protein at lysine 757 and consequentially activates the Hh signaling, and itself serves as a direct target of Hh signaling to format a positive regulating loop.	Lysine	86-92	GLI family zinc finger 2	Homo sapiens	70-74
32008421-2	2020	Here, the patent landscape surrounding lysine acetyltransferase inhibitors (KATi or HATi), with a focus on small-molecule compounds, is outlined and assessed.	Lysine	39-45	kynurenine aminotransferase 1	Homo sapiens	76-80
31576654-2	2019	The lysine methyltransferase, SETDB1, is one of the enzymes responsible for the methylation of histone H3 at lysine 9 (H3K9) and plays a key role in H3K9 trimethylation-mediated silencing of genes and retrotransposons.	Lysine	4-10	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	30-36
31002112-10	2019	Further analysis confirmed that lysines 381, 382, 386 of p53 are the key sites for the ubiquitination modification of SMYD3 to p53.	Lysine	32-39	tumor protein p53	Homo sapiens	57-60
31002112-10	2019	Further analysis confirmed that lysines 381, 382, 386 of p53 are the key sites for the ubiquitination modification of SMYD3 to p53.	Lysine	32-39	tumor protein p53	Homo sapiens	127-130
31529537-3	2019	This highly polar and unstable compound forms a remarkably stable Schiff base with a lysine residue in the protein MR1 expressed in antigen-presenting cells.	Lysine	85-91	major histocompatibility complex, class I-related	Homo sapiens	115-118
31642121-5	2020	Using this tool, we have identified a putative domain enriched in hydrophilic and disorder-promoting residues (Pro, Ser, and Thr) and depleted in positive charges (Arg and Lys) bordering the folded DNA-binding domains of several transcription factors (p53, GCR, NAC46, MYB28, and MYB29).	Lysine	172-175	tumor protein p53	Homo sapiens	252-255
31642121-5	2020	Using this tool, we have identified a putative domain enriched in hydrophilic and disorder-promoting residues (Pro, Ser, and Thr) and depleted in positive charges (Arg and Lys) bordering the folded DNA-binding domains of several transcription factors (p53, GCR, NAC46, MYB28, and MYB29).	Lysine	172-175	nuclear receptor subfamily 3 group C member 1	Homo sapiens	257-260
31725295-0	2019	Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.	Lysine	24-30	heat shock protein family A (Hsp70) member 1A	Homo sapiens	64-69
31725295-3	2019	We have recently reported our discovery that lysine-56 in the difficult-to-drug target HSP72 could form a covalent bond with a small-molecule inhibitor.	Lysine	45-51	heat shock protein family A (Hsp70) member 1A	Homo sapiens	87-92
31856708-8	2019	The ZNF746 protein segment encoded by exons 5 and 6 boosted repressor potency, potentially due to the presence of an acceptor lysine for sumoylation at K189.	Lysine	126-132	zinc finger protein 746	Homo sapiens	4-10
31131878-2	2019	The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9.	Lysine	94-100	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	30-36
31576654-2	2019	The lysine methyltransferase, SETDB1, is one of the enzymes responsible for the methylation of histone H3 at lysine 9 (H3K9) and plays a key role in H3K9 trimethylation-mediated silencing of genes and retrotransposons.	Lysine	109-115	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	30-36
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	135-141	CREB binding protein	Homo sapiens	45-48
31546024-3	2019	Our results indicated that the SUMO1 acceptor site of NRF2 is the conserved lysine residue 110 (K110), and that NRF2 SUMOylation deficiency inhibited tumorigenesis in hepatocellular carcinoma (HCC).	Lysine	76-82	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	135-141	CREB binding protein	Homo sapiens	63-68
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	336-342	CREB binding protein	Homo sapiens	45-48
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	336-342	CREB binding protein	Homo sapiens	63-68
31550663-3	2019	Upon protein-protein interaction (PPI) between the catalytic subunit EZH2 and EED, PRC2 primarily methylates lysine 27 of histone H3 (H3K27me3), thus modulating the chromatin structure and inducing transcriptional repression.	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	69-73
31396854-3	2019	EZH2 can catalyze trimethylation of histone H3 at lysine 27 (H3K27me3) and contribute to transcriptional silencing of target genes.	Lysine	50-56	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
31422102-4	2019	SETDB1 catalyzes the epigenetic mark of lysine-9 methylation of histone-3.	Lysine	40-46	eggless	Drosophila melanogaster	0-6
31647887-9	2019	Using chromatin immunoprecipitation analysis, we found that mTOR expression was associated with promoter methylation and an enrichment for mono- and dimethylated histone 3 lys 9 (H3K9).	Lysine	39-42	mechanistic target of rapamycin kinase	Homo sapiens	60-64
31514090-2	2019	THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin that uses a lysine residue in the E helix (Lys53, at position E10 by reference to myoglobin) as an iron ligand at neutral pH.	Lysine	116-122	uncharacterized protein	Chlamydomonas reinhardtii	0-4
30194628-0	2019	An In-Silico Investigation of Key Lysine Residues and Their Selection for Clearing off Abeta and Holo-AbetaPP Through Ubiquitination.	Lysine	34-40	amyloid beta precursor protein	Homo sapiens	87-92
31442507-6	2019	The modification system is dependent on lysine 83 (ATPase activity site) and cysteine 169 (zinc binding site) in ThiF and three important substrates, GroEL, PriC, FtsA, were found to be covalently modified by this system in vitro.	Lysine	40-46	GroEL	Escherichia coli	150-155
31514090-2	2019	THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin that uses a lysine residue in the E helix (Lys53, at position E10 by reference to myoglobin) as an iron ligand at neutral pH.	Lysine	116-122	uncharacterized protein	Chlamydomonas reinhardtii	59-63
31514090-4	2019	In THB1, these amino acids would each be expected to convey distinct reactive properties if replacing the native lysine as an axial ligand.	Lysine	113-119	uncharacterized protein	Chlamydomonas reinhardtii	3-7
31752930-1	2019	EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along with other PRC2 components mediates gene expression suppression via the methylation of Histone H3 at lysine 27.	Lysine	188-194	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
31140128-0	2019	Correction to: Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression.	Lysine	76-82	methyl-CpG binding protein 2	Homo sapiens	153-158
31140128-0	2019	Correction to: Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression.	Lysine	76-82	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	163-167
31885199-7	2019	Instead, we provide evidence that the time-varying acetylation state of p53"s C-terminal lysine residues is critical for gene-specific regulation of stochastic bursting.	Lysine	89-95	tumor protein p53	Homo sapiens	72-75
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	74-80	androgen receptor	Homo sapiens	88-90
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	74-80	androgen receptor	Homo sapiens	88-90
31752909-9	2019	Moreover, PIAS1 itself is modified by SUMO3 overexpression, and mutation of SUMO-acceptor lysine 117 on PIAS1 can impair AR cytoplasmic distribution, demonstrating the essential role of sumoylated PIAS1 in AR translocation.	Lysine	90-96	androgen receptor	Homo sapiens	121-123
31752909-9	2019	Moreover, PIAS1 itself is modified by SUMO3 overexpression, and mutation of SUMO-acceptor lysine 117 on PIAS1 can impair AR cytoplasmic distribution, demonstrating the essential role of sumoylated PIAS1 in AR translocation.	Lysine	90-96	androgen receptor	Homo sapiens	206-208
31752909-10	2019	We further determine that sumoylated PIAS1 interacts with AR lysine 386 and 845 to form a binary complex.	Lysine	61-67	androgen receptor	Homo sapiens	58-60
31524790-6	2019	DOT1L is a methyltransferase that methylates histone H3 lysine 79 (H3K79).	Lysine	56-62	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
31306746-5	2019	This platform was readily "codified" with respect to both position and extent of methylation at histone 3 lysines 18 and 36 and led to the conclusion that the most readily discernible activity of NSD2 in contact with a nucleosome substrate is dimethylation of histone 3 lysine 36.	Lysine	106-113	nuclear receptor binding SET domain protein 2	Homo sapiens	196-200
31306746-5	2019	This platform was readily "codified" with respect to both position and extent of methylation at histone 3 lysines 18 and 36 and led to the conclusion that the most readily discernible activity of NSD2 in contact with a nucleosome substrate is dimethylation of histone 3 lysine 36.	Lysine	106-112	nuclear receptor binding SET domain protein 2	Homo sapiens	196-200
31587141-1	2019	BACKGROUND: Kabuki syndrome (KS), is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase (KMT2D) or an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A).	Lysine	110-116	lysine demethylase 6A	Homo sapiens	186-189
31587141-1	2019	BACKGROUND: Kabuki syndrome (KS), is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase (KMT2D) or an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A).	Lysine	110-116	lysine demethylase 6A	Homo sapiens	190-195
31587141-1	2019	BACKGROUND: Kabuki syndrome (KS), is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase (KMT2D) or an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A).	Lysine	163-169	lysine demethylase 6A	Homo sapiens	186-189
31587141-1	2019	BACKGROUND: Kabuki syndrome (KS), is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase (KMT2D) or an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A).	Lysine	163-169	lysine demethylase 6A	Homo sapiens	190-195
31660568-4	2019	Gold nanoparticles (AuNPs) were synthesized on bovine serum albumin (BSA) via an in situ growth method and modified with a poly-l-lysine (PLL) layer, yielding Au@BSA@PLL nanotracers with enhanced biocompatibility and intracellular uptake.	Lysine	123-136	albumin	Homo sapiens	54-67
31578285-6	2019	We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages.	Lysine	192-195	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	107-111
31644285-2	2019	The catalytic activity of a number of vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lysine lipoylation.	Lysine	113-119	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	72-94
31644285-2	2019	The catalytic activity of a number of vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lysine lipoylation.	Lysine	113-119	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	96-99
31578285-6	2019	We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages.	Lysine	206-209	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	107-111
31722219-3	2019	More importantly, CCDC84 acetylation oscillates throughout the cell cycle, and the acetylation state of CCDC84 at lysine 31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10.	Lysine	114-120	N-acetyltransferase 10	Homo sapiens	188-193
31719525-0	2019	Inhibiting lysine 353 oxidation of GRP78 by a hypochlorous probe targeting endoplasmic reticulum promotes autophagy in cancer cells.	Lysine	11-17	heat shock protein family A (Hsp70) member 5	Homo sapiens	35-40
31526565-2	2019	NSD2 belongs to the NSD family of histone lysine methyltransferases (HMTases), and is a histone methyltransferase that regulates dimethylation of histone 3 lysine 36 (H3K36me2).	Lysine	42-48	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
31719525-7	2019	In addition, mass spectrometry combined with point mutation experiments revealed that ZBM-H increased GRP78 activity by inhibiting HOCl-induced lysine 353 oxidation of GRP78.	Lysine	144-150	heat shock protein family A (Hsp70) member 5	Homo sapiens	102-107
31719525-7	2019	In addition, mass spectrometry combined with point mutation experiments revealed that ZBM-H increased GRP78 activity by inhibiting HOCl-induced lysine 353 oxidation of GRP78.	Lysine	144-150	heat shock protein family A (Hsp70) member 5	Homo sapiens	168-173
31521505-1	2019	Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27.	Lysine	136-142	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	68-74
31515273-4	2019	Here, we characterized the interaction of the CBP-KIX domain with BMAL1 proteins including the BMAL1-TAD, parts of the G-region, and Lys-537.	Lysine	133-136	CREB binding protein	Homo sapiens	46-49
31231131-7	2019	Ascl1 regulated Wnt11 expression via lysine H3K27 acetylation at the enhancer region of the WNT11 gene.	Lysine	37-43	Wnt family member 11	Homo sapiens	16-21
31374292-4	2019	We found that histone H3 lysine 4 (H3K4) demethylase RBP2 expression is negatively correlated with BCR-ABL expression, which suggests a regulatory link between these two genes.	Lysine	25-31	retinol binding protein 2	Homo sapiens	53-57
31596625-10	2019	Most interestingly, within ET-1 first intron, reduced DNA methylation and enhanced tri-methylation of lysine 4 on histone H3 were observed in PVECs and sperm of first generation of IUGR, with DNA demethylation in PVECs of second generation of IUGR.	Lysine	102-108	endothelin 1	Homo sapiens	27-31
31700102-0	2019	Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer.	Lysine	31-38	dishevelled segment polarity protein 1	Homo sapiens	25-30
31700102-5	2019	Herein, we report 12 DVL-1 lysine residues that show differential acetylation in response to changes in oxygen tension and deacetylase inhibition in triple-negative breast cancer (TNBC).	Lysine	27-33	dishevelled segment polarity protein 1	Homo sapiens	21-26
31700102-7	2019	We also identify that acetylation of two key lysine residues, K69 and K285, present on the DIX and PDZ domains respectively, promote nuclear over cytoplasmic localization of DVL-1, and influences its promoter binding and regulation of genes implicated in cancer.	Lysine	45-51	dishevelled segment polarity protein 1	Homo sapiens	174-179
31693890-0	2019	Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.	Lysine	37-43	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	14-18
31693890-1	2019	The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	60-64
31693890-3	2019	Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1).	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	80-84
31685013-1	2019	SETD1B is a component of a histone methyltransferase complex that specifically methylates Lys-4 of histone H3 (H3K4) and is responsible for the epigenetic control of chromatin structure and gene expression.	Lysine	90-93	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	0-6
31685935-3	2019	We find that H3K18ac and H3K27ac differentially influence the combined activities of UDG/APE1 on compact chromatin, suggesting that acetylated lysine residues on the H3 tail domain play distinct roles in regulating the initial steps of BER.	Lysine	143-149	uracil DNA glycosylase	Homo sapiens	85-88
31446241-7	2019	In addition, mass spectrometry-based lysine labeling reactivity assay suggested that the biflavones could bind on human thrombin at exosite I rather than exosite II.	Lysine	37-43	coagulation factor II, thrombin	Homo sapiens	120-128
30787391-7	2019	Mechanistically, Sirt6 deacetylated ERalpha protein to prevent its proteasomal degradation, in which lysine 171 and lysine 299 were critical residues.	Lysine	101-107	sirtuin 6	Mus musculus	17-22
30787391-7	2019	Mechanistically, Sirt6 deacetylated ERalpha protein to prevent its proteasomal degradation, in which lysine 171 and lysine 299 were critical residues.	Lysine	116-122	sirtuin 6	Mus musculus	17-22
31288248-6	2019	RESULTS: WES analysis revealed a novel homozygous nonsense mutation in lysine 2 of fetuin-A, encoded by the ALPHA-2-HS-GLYCOPROTEIN (AHSG) gene (c.A4T; p.K2X).	Lysine	71-77	alpha 2-HS glycoprotein	Homo sapiens	83-91
31288248-6	2019	RESULTS: WES analysis revealed a novel homozygous nonsense mutation in lysine 2 of fetuin-A, encoded by the ALPHA-2-HS-GLYCOPROTEIN (AHSG) gene (c.A4T; p.K2X).	Lysine	71-77	alpha 2-HS glycoprotein	Homo sapiens	108-131
31288248-6	2019	RESULTS: WES analysis revealed a novel homozygous nonsense mutation in lysine 2 of fetuin-A, encoded by the ALPHA-2-HS-GLYCOPROTEIN (AHSG) gene (c.A4T; p.K2X).	Lysine	71-77	alpha 2-HS glycoprotein	Homo sapiens	133-137
31502937-1	2019	Background Recent studies have reported the additive value of combined gallium 68 (68Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting the prostate-specific membrane antigen (PSMA) (hereafter called 68Ga-PSMA-11) PET/MRI for the detection and localization of primary prostate cancer compared with multiparametric MRI.	Lysine	106-109	folate hydrolase 1	Homo sapiens	145-179
31265113-7	2019	Moreover, relative expression of peroxisome proliferator-activated receptors alpha, carnitine palmitoyltransferase 1A, and very low density apolipoprotein-II increased linearly (P &lt; 0.05) and quadratically (P &lt; 0.05), and that of VLDL receptor (VLDLR) decreased quadratically (P &lt; 0.05) in the liver of duck breeders with increasing dietary Lys levels; hepatic triglyceride and cholesterol contents were reduced.	Lysine	350-353	carnitine palmitoyltransferase 1A	Homo sapiens	44-117
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	platelet derived growth factor receptor beta	Homo sapiens	150-155
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	156-159
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	epidermal growth factor receptor	Homo sapiens	161-165
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	AKT serine/threonine kinase 1	Homo sapiens	233-236
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	mechanistic target of rapamycin kinase	Homo sapiens	237-241
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	tumor protein p53	Homo sapiens	345-349
31502937-1	2019	Background Recent studies have reported the additive value of combined gallium 68 (68Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting the prostate-specific membrane antigen (PSMA) (hereafter called 68Ga-PSMA-11) PET/MRI for the detection and localization of primary prostate cancer compared with multiparametric MRI.	Lysine	106-109	folate hydrolase 1	Homo sapiens	181-185
31497948-3	2019	Modification of the tip wall with poly-l-lysine allowed adsorption of tissue transglutaminase (tTG), which will capture later anti-tTG (IgA) antibodies developed in celiac-affected people.	Lysine	34-47	transglutaminase 2	Homo sapiens	70-93
31666665-2	2019	In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3).	Lysine	220-226	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	61-89
31666665-2	2019	In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3).	Lysine	220-226	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	91-95
31666665-2	2019	In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3).	Lysine	220-226	DAB2 interacting protein	Homo sapiens	111-149
31666665-2	2019	In cancer, epigenetic modifications affect the expression of Enhancer of Zester Homolog 2 (EZH2), and silenced disabled homolog 2 interacting protein gene (DAB2IP) (onco-suppressor gene) by Histone H3 tri-methylation in lysine 27 (H3K27me3).	Lysine	220-226	DAB2 interacting protein	Homo sapiens	156-162
31497948-3	2019	Modification of the tip wall with poly-l-lysine allowed adsorption of tissue transglutaminase (tTG), which will capture later anti-tTG (IgA) antibodies developed in celiac-affected people.	Lysine	34-47	transglutaminase 2	Homo sapiens	95-98
31497948-3	2019	Modification of the tip wall with poly-l-lysine allowed adsorption of tissue transglutaminase (tTG), which will capture later anti-tTG (IgA) antibodies developed in celiac-affected people.	Lysine	34-47	transglutaminase 2	Homo sapiens	131-134
31492675-1	2019	The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression.	Lysine	115-121	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	56-60
31525019-1	2019	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2 (PRC2), regulates chromatin state and gene expression by methylating histone H3 lysine 27.	Lysine	175-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
31525019-1	2019	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2 (PRC2), regulates chromatin state and gene expression by methylating histone H3 lysine 27.	Lysine	175-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
31384983-3	2019	HER2 aptamer was immobilized by electrostatic adsorption on the surface of a homemade screen-printed electrode modified with poly-L-lysine.	Lysine	125-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
31274540-13	2019	Overexpression of domain negative YB-1 mutants illustrated that a residue Lysine at 118 plays a key role in supporting HIV infection in CD4 T cells.	Lysine	74-80	Y-box binding protein 1	Homo sapiens	34-38
31274540-13	2019	Overexpression of domain negative YB-1 mutants illustrated that a residue Lysine at 118 plays a key role in supporting HIV infection in CD4 T cells.	Lysine	74-80	CD4 molecule	Homo sapiens	136-139
31062674-9	2019	In biceps femoris muscle of lysine-deficient pigs, the activity of FAS and ME enzymes increased, ME1 gene was upregulated (added to FASN gene in the case of Iberian pigs; P < 0.01 to P < 0.001) and PPARA gene was downregulated (P < 0.05).	Lysine	28-34	malic enzyme 1	Sus scrofa	97-100
31619182-1	2019	BACKGROUND: Polycomb repressive complex 2 (PRC2) is an epigenetic transcriptional repression system, whose catalytic subunit (ENHANCER OF ZESTE HOMOLOG 2, EZH2 in animals) is responsible for trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	220-226	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	155-159
31492752-4	2019	Mass spectrometry and biochemical analysis of the reaction products identified lysine residues as p53 ubiquitination sites.	Lysine	79-85	tumor protein p53	Homo sapiens	98-101
31492752-5	2019	A p53 mutant with arginine substitutions of its 18 lysine residues was not ubiquitinated.	Lysine	51-57	tumor protein p53	Homo sapiens	2-5
31175912-4	2019	Here we describe the in vitro binding properties of FL-UBQLN1 with the S5a subunit of the proteasome and two different lysine-linked (K48 or K63) ubiquitin chains.	Lysine	119-125	ubiquilin 1	Homo sapiens	55-61
30728459-12	2019	Furthermore, PGC1beta-OT1 affected the expression of endogenous miR-148a-3p and its target gene lysine-specific demethylase 6b (KDM6B).	Lysine	96-102	lysine demethylase 6B	Sus scrofa	128-133
31404772-8	2019	L-Lysine treatment significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts.	Lysine	0-8	tumor necrosis factor	Mus musculus	131-158
31295528-7	2019	In addition, ethanol exposure reduced the levels of trimethylation of histone H3 lysine 4 (H3K4me3) at the promoters of Snail1.	Lysine	81-87	snail family transcriptional repressor 1	Homo sapiens	120-126
31116475-8	2019	Our data suggest that dysfunction of cytoplasmic KARS resulted in a decreased level of translation of the nuclear-encoded lysine-rich proteins belonging to the respiratory chain complex, thus impairing mitochondria functions.	Lysine	122-128	lysyl-tRNA synthetase 1	Homo sapiens	49-53
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	bromodomain containing 4	Homo sapiens	36-40
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	snail family transcriptional repressor 1	Homo sapiens	93-98
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	snail family transcriptional repressor 1	Homo sapiens	110-115
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	snail family transcriptional repressor 1	Homo sapiens	110-115
31488576-3	2019	Using mass spectrometry analysis of recombinant human PRC2, we identified three methylated lysine residues (K510, K514, and K515) on a disordered but highly conserved loop of EZH2.	Lysine	91-97	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	175-179
31488576-5	2019	De novo histone methylation in an EZH2 knockout cell line is greatly impeded by mutation of the automethylation lysines.	Lysine	112-119	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
31488577-3	2019	Here, we identify the lysine residues at which EZH1/EZH2 are automethylated with EZH2-K510 and EZH2-K514 being the major such sites in vivo.	Lysine	22-28	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	52-56
31488577-3	2019	Here, we identify the lysine residues at which EZH1/EZH2 are automethylated with EZH2-K510 and EZH2-K514 being the major such sites in vivo.	Lysine	22-28	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	81-85
31488577-3	2019	Here, we identify the lysine residues at which EZH1/EZH2 are automethylated with EZH2-K510 and EZH2-K514 being the major such sites in vivo.	Lysine	22-28	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	81-85
31488577-6	2019	Intriguingly, EZH2 automethylation is significantly reduced in diffuse intrinsic pontine glioma (DIPG) cells that carry a lysine-to-methionine substitution in histone H3 (H3K27M), but not in cells that carry either EZH2 or EED mutants that abrogate PRC2 allosteric activation, indicating that H3K27M impairs the intrinsic activity of PRC2.	Lysine	122-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	14-18
31121257-6	2019	Furthermore, we verified an increase of Nrf2 and NF-kappaB expression in the nuclear fraction, and a decrease of heme oxygenase-1 (HO-1) content in the striatum of Lys-injected Gcdh-/- mice, implying disruption of redox homeostasis.	Lysine	164-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
31121257-6	2019	Furthermore, we verified an increase of Nrf2 and NF-kappaB expression in the nuclear fraction, and a decrease of heme oxygenase-1 (HO-1) content in the striatum of Lys-injected Gcdh-/- mice, implying disruption of redox homeostasis.	Lysine	164-167	heme oxygenase 1	Mus musculus	113-129
31121257-6	2019	Furthermore, we verified an increase of Nrf2 and NF-kappaB expression in the nuclear fraction, and a decrease of heme oxygenase-1 (HO-1) content in the striatum of Lys-injected Gcdh-/- mice, implying disruption of redox homeostasis.	Lysine	164-167	heme oxygenase 1	Mus musculus	131-135
31300558-1	2019	Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes.	Lysine	29-35	DOT1 like histone lysine methyltransferase	Homo sapiens	50-55
31616951-5	2019	MORC2, in turn, stabilizes PARP1 through enhancing acetyltransferase NAT10-mediated acetylation of PARP1 at lysine 949, which blocks its ubiquitination at the same residue and subsequent degradation by E3 ubiquitin ligase CHFR.	Lysine	108-114	poly(ADP-ribose) polymerase 1	Homo sapiens	27-32
31547042-2	2019	Tissue transglutaminase (TG2) is a key factor in CD pathogenesis, because it catalyzes both the deamidation of specific glutamine residues and the formation of covalent Nepsilon-(gamma-glutamyl)-lysine isopeptide crosslinks resulting in TG2-gluten peptide complexes.	Lysine	195-201	transglutaminase 2	Homo sapiens	0-23
31557926-1	2019	SETDB1 (SET Domain Bifurcated histone lysine methyltransferase 1) is a key lysine methyltransferase (KMT) required in embryonic stem cells (ESCs), where it silences transposable elements and DNA repeats via histone H3 lysine 9 tri-methylation (H3K9me3), independently of DNA methylation.	Lysine	38-44	SET domain, bifurcated 1	Mus musculus	0-6
31616951-5	2019	MORC2, in turn, stabilizes PARP1 through enhancing acetyltransferase NAT10-mediated acetylation of PARP1 at lysine 949, which blocks its ubiquitination at the same residue and subsequent degradation by E3 ubiquitin ligase CHFR.	Lysine	108-114	N-acetyltransferase 10	Homo sapiens	69-74
31616951-5	2019	MORC2, in turn, stabilizes PARP1 through enhancing acetyltransferase NAT10-mediated acetylation of PARP1 at lysine 949, which blocks its ubiquitination at the same residue and subsequent degradation by E3 ubiquitin ligase CHFR.	Lysine	108-114	poly(ADP-ribose) polymerase 1	Homo sapiens	99-104
31346036-6	2019	The polyubiquitylation of p53 occurred via Lys-48 linkage and involved phosphorylation on p53 at Ser-33 and Ser-37 by glycogen synthase kinase 3beta (GSK3beta) and DNA-dependent protein kinase (DNA-PK), respectively.	Lysine	43-46	tumor protein p53	Homo sapiens	26-29
31301308-9	2019	The antimigratory, but not the pro-apoptotic, effects of Cat:Lys were found to be mediated by JAK2/STAT3 and Wnt pathway inhibition.	Lysine	61-64	signal transducer and activator of transcription 3	Homo sapiens	99-104
31519887-3	2019	Here, we generate Ripk1K376R/K376R knock-in mice in which the Lys(K)63-linked ubiquitination of RIPK1 is impaired.	Lysine	62-65	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	18-23
31519887-3	2019	Here, we generate Ripk1K376R/K376R knock-in mice in which the Lys(K)63-linked ubiquitination of RIPK1 is impaired.	Lysine	62-65	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	96-101
31509528-0	2019	Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase.	Lysine	76-82	antizyme inhibitor 2 S homeolog	Xenopus laevis	46-53
31509528-0	2019	Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase.	Lysine	76-82	antizyme inhibitor 2 S homeolog	Xenopus laevis	54-60
31509528-7	2019	xlAZIN2 did not behave as an antizyme inhibitor, but it rather acts as an authentic decarboxylase forming cadaverine, due to its higher affinity to L-lysine than to L-ornithine as substrate; so, in accordance with this, it should be named as lysine decarboxylase (LDC) or lysine/ornithine decarboxylase (LODC).	Lysine	148-156	antizyme inhibitor 2 S homeolog	Xenopus laevis	0-7
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	SATB homeobox 2	Homo sapiens	17-22
31346036-6	2019	The polyubiquitylation of p53 occurred via Lys-48 linkage and involved phosphorylation on p53 at Ser-33 and Ser-37 by glycogen synthase kinase 3beta (GSK3beta) and DNA-dependent protein kinase (DNA-PK), respectively.	Lysine	43-46	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	164-192
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	WD repeat domain 5	Homo sapiens	45-49
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	SATB homeobox 2	Homo sapiens	78-83
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	SATB homeobox 2	Homo sapiens	78-83
31346036-6	2019	The polyubiquitylation of p53 occurred via Lys-48 linkage and involved phosphorylation on p53 at Ser-33 and Ser-37 by glycogen synthase kinase 3beta (GSK3beta) and DNA-dependent protein kinase (DNA-PK), respectively.	Lysine	43-46	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	194-200
31346036-7	2019	These phosphorylation events created a phosphodegron that enhanced p53 binding to FBW7alpha, allowing for the attachment of polyubiquitin moieties at Lys-132 in p53.	Lysine	150-153	tumor protein p53	Homo sapiens	67-70
31346036-7	2019	These phosphorylation events created a phosphodegron that enhanced p53 binding to FBW7alpha, allowing for the attachment of polyubiquitin moieties at Lys-132 in p53.	Lysine	150-153	tumor protein p53	Homo sapiens	161-164
31346036-10	2019	Phosphodegron-mediated polyubiquitylation of p53 on Lys-132 had functional consequences, with cells in which FBW7alpha-mediated p53 degradation was abrogated exhibiting enhancement of their tumorigenic potential.	Lysine	52-55	tumor protein p53	Homo sapiens	45-48
31413200-10	2019	In situ trapping of the reaction intermediates (DNA-TFAM cross-links) revealed that the reaction proceeds via Schiff base chemistry facilitated by lysine residues.	Lysine	147-153	transcription factor A, mitochondrial	Homo sapiens	52-56
30980288-7	2019	In conclusion, phenylalanine, arginine, and lysine were found to affect the nucleation phase of lysozyme aggregation and could be considered as suitable stabilizing structures for this enzyme.	Lysine	44-50	lysozyme	Homo sapiens	96-104
31165984-11	2019	The results indicated that a strong interaction existed between Homo sapiens lysine-rich coil-coiled and SAG1 protein, which could activate the expressions of the reporter genes in diploid yeast.	Lysine	77-83	Sag1p	Saccharomyces cerevisiae S288C	105-109
31238259-7	2019	L-Lysine significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts, and it increased the reduced glutathione levels and the glutathione peroxidase, superoxide dismutase, and catalase activities.	Lysine	0-8	tumor necrosis factor	Rattus norvegicus	121-148
31238259-7	2019	L-Lysine significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts, and it increased the reduced glutathione levels and the glutathione peroxidase, superoxide dismutase, and catalase activities.	Lysine	0-8	catalase	Rattus norvegicus	377-385
31175983-7	2019	In the mouse model, hMPO was expressed in neurons colocalizing with nitrated alphaSyn, carbamylated lysine, nitrotyrosine, as well as HOCl-modified epitopes/proteins.	Lysine	100-106	myeloperoxidase	Homo sapiens	20-24
31399698-0	2019	Histone lysine de-beta-hydroxybutyrylation by SIRT3.	Lysine	8-14	sirtuin 3	Homo sapiens	46-51
31238008-5	2019	Lysine 151 residue was identified as a ubiquitin acceptor site within TTF1 in both cell types.	Lysine	0-6	NK2 homeobox 1	Homo sapiens	70-74
31326241-2	2019	Hispolon size, smaller than curcumin, fits better than curcumin into the active site of HDAC6, an enzyme involved in deacetylation of lysine residues.	Lysine	134-140	histone deacetylase 6	Homo sapiens	88-93
31327677-2	2019	In addition to its catalytic domain, SETDB1 harbors a unique tandem tudor domain which recognizes histone sequences containing both methylated and acetylated lysines, and likely contributes to its localization on chromatin.	Lysine	158-165	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	37-43
31310433-3	2019	To overcome these limitations, a biocompatible and thermosensitive biopolymer-C-peptide conjugate composed of human C-peptide genetically conjugated at the C-terminus of nine repeats of lysine-containing elastin-like polypeptide (K9-C-peptide) is generated.	Lysine	186-192	insulin	Homo sapiens	78-87
31326165-11	2019	Our results indicate that casein synthesis was regulated by Lys/Met ratio via JAK2/ELF5, mTOR, and its downstream RPS6KB1 and EIF4EBP1 signaling.	Lysine	60-63	ribosomal protein S6 kinase B1	Bos taurus	114-121
31228513-12	2019	Actin was identified as a novel substrate of CRT, being acetylated mainly through the CRT P-domain at lys-206 and -207.	Lysine	102-105	calreticulin	Homo sapiens	45-48
31228513-12	2019	Actin was identified as a novel substrate of CRT, being acetylated mainly through the CRT P-domain at lys-206 and -207.	Lysine	102-105	calreticulin	Homo sapiens	86-89
30185944-6	2019	The limit of detection was 0.5 pg of AFB1-lys/mg albumin.	Lysine	42-45	albumin	Homo sapiens	49-56
30185944-7	2019	In 744 plasma samples, the geometric mean of AFB1-lysine/mg albumin was 1.07 pg (range 0.04-123.5 pg/mg albumin).	Lysine	50-56	albumin	Homo sapiens	60-67
31310433-3	2019	To overcome these limitations, a biocompatible and thermosensitive biopolymer-C-peptide conjugate composed of human C-peptide genetically conjugated at the C-terminus of nine repeats of lysine-containing elastin-like polypeptide (K9-C-peptide) is generated.	Lysine	186-192	insulin	Homo sapiens	116-125
31310433-3	2019	To overcome these limitations, a biocompatible and thermosensitive biopolymer-C-peptide conjugate composed of human C-peptide genetically conjugated at the C-terminus of nine repeats of lysine-containing elastin-like polypeptide (K9-C-peptide) is generated.	Lysine	186-192	insulin	Homo sapiens	116-125
31266808-0	2019	Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-beta1-induced gene expression in mesangial cells and diabetic kidney.	Lysine	28-34	BCL2 related protein A1	Homo sapiens	83-88
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	101-106
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	111-116
31375747-5	2019	We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start sites (TSS) and super-enhancers (SEs) prominently in stem-like BrCa cells.	Lysine	136-142	histone deacetylase 1	Homo sapiens	14-19
31320481-4	2019	We show that the Mediator subunit MED25 physically recruits LUH to MYC2 target promoters that then links MYC2 with HAC1-dependent acetylation of Lys-9 of histone H3 (H3K9ac) to activate JAZ2 and LOX2 Moreover, LUH promotes hormone-dependent enhancement of protein interactions between MYC2 and its coactivators MED25 and HAC1.	Lysine	145-148	tripartite motif containing 3	Homo sapiens	115-119
31320481-4	2019	We show that the Mediator subunit MED25 physically recruits LUH to MYC2 target promoters that then links MYC2 with HAC1-dependent acetylation of Lys-9 of histone H3 (H3K9ac) to activate JAZ2 and LOX2 Moreover, LUH promotes hormone-dependent enhancement of protein interactions between MYC2 and its coactivators MED25 and HAC1.	Lysine	145-148	tripartite motif containing 3	Homo sapiens	321-325
31461020-8	2019	In an epigenetic survey of the promoters of four osteogenic regulator genes (RUNX2, SP7, ATF4, and BGLAP), the authors found a general trend toward decreased CpG methylation and increased trimethylation of histone H3 at lysine 4 levels in ceiling culture-derived preadipocytes as compared to adipose-derived stem cells, indicating that these genes were more likely to be highly expressed in ceiling culture-derived preadipocytes.	Lysine	220-226	RUNX family transcription factor 2	Homo sapiens	77-82
31461020-8	2019	In an epigenetic survey of the promoters of four osteogenic regulator genes (RUNX2, SP7, ATF4, and BGLAP), the authors found a general trend toward decreased CpG methylation and increased trimethylation of histone H3 at lysine 4 levels in ceiling culture-derived preadipocytes as compared to adipose-derived stem cells, indicating that these genes were more likely to be highly expressed in ceiling culture-derived preadipocytes.	Lysine	220-226	bone gamma-carboxyglutamate protein	Homo sapiens	99-104
31314501-7	2019	Through mass spectrometry (MS), we found that only 6 out of 60 (10%) lysine groups present in bovine serum albumin (BSA) were accessible to the membrane of the vesicles.	Lysine	69-75	albumin	Homo sapiens	101-114
31422747-5	2019	This indicated potential interaction between negatively charged residues in the alphaCT1 Asp-Asp-Leu-Glu-Iso sequence and lysines (Lys345, Lys346) in an alpha-helical sequence (helix 2) within the Cx43-CT.	Lysine	122-129	gap junction protein, alpha 1	Mus musculus	197-201
31340641-7	2019	To explore the detection mechanism, three unique polar binding sites on albumin are computationally identified, where the multivalent tetrazolate-lysine interactions contribute to the tight binding and restriction of the molecular motion of the AIE probes.	Lysine	146-152	albumin	Homo sapiens	72-79
31248990-1	2019	NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation.	Lysine	78-84	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	signal transducer and activator of transcription 3	Mus musculus	0-57
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	signal transducer and activator of transcription 3	Mus musculus	61-66
31202458-8	2019	ChIP-qPCR showed that DLX3 knockdown promoted DKK4 expression by decreasing the enrichment of histone H3 lysine 27 trimethylation (H3K27me3) in the promotor region of DKK4.	Lysine	105-111	distal-less homeobox 3	Homo sapiens	22-26
31248772-5	2019	In this study we describe the development of Glu-urea-Lys based PSMA-targeting conjugates with paclitaxel.	Lysine	54-57	folate hydrolase 1	Homo sapiens	64-68
31419226-1	2019	Enhancer of zeste homolog 2 (EZH2) tri-methylates histone 3 at position lysine 27 (H3K27me3).	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
31419226-1	2019	Enhancer of zeste homolog 2 (EZH2) tri-methylates histone 3 at position lysine 27 (H3K27me3).	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
31416910-4	2019	A critical target of OGT is the polycomb repressive complex 2 (PRC2) containing the histone lysine methyltransferase EZH2 that mediates trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	117-121
31271281-1	2019	Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the side chain of acetylated lysine residues in cytoplasmic proteins such as alpha-tubulin and HSP90.	Lysine	112-118	histone deacetylase 6	Homo sapiens	0-21
31447696-4	2019	SIRT4 also appears to have enzymatic functions involved in posttranslational modifications such as ADP-ribosylation, lysine deacetylation and lipoamidation.	Lysine	117-123	sirtuin 4	Homo sapiens	0-5
31271281-1	2019	Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the side chain of acetylated lysine residues in cytoplasmic proteins such as alpha-tubulin and HSP90.	Lysine	112-118	histone deacetylase 6	Homo sapiens	23-28
31253574-3	2019	The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and contain the lysine-63 linkage-specific BRCC36 subunit that is functionalized by scaffold subunits ABRAXAS and ABRO1, respectively.	Lysine	109-115	abraxas 2, BRISC complex subunit	Homo sapiens	207-212
31388677-9	2019	A weak transcription activity of Cr(VI)-upregulated p53 was associated with its low lysine acetylation in the regulatory C-terminal domain, resulting from the inability of Cr(VI) to activate ATM in ascorbate-restored cells.	Lysine	84-90	tumor protein p53	Homo sapiens	52-55
31390542-2	2019	(2019) demonstrate that the cell cycle regulator UBE2S shuts itself off through autoubiquitination at a conserved lysine residue.	Lysine	114-120	ubiquitin conjugating enzyme E2 S	Homo sapiens	49-54
31208706-5	2019	Interestingly, the addition of 6 lysine residues to the N-terminus of ApoEp (6KApoEp) directly inhibited apoE binding to N-terminal APP and markedly limited apoE- and ApoEp-mediated Abeta generation, presumably through decreasing APP cellular membrane trafficking and p44/42 mitogen-activated protein kinase phosphorylation.	Lysine	33-39	apolipoprotein E	Mus musculus	70-75
30950230-4	2019	We previously demonstrated that overexpression of mutant FGFR1-25R (25 out of 29 intracellular lysines replaced with arginine) results in enhanced receptor recycling as compared to wild-type FGFR1 followed by strong stimulation of elongative axon growth in vitro.	Lysine	95-102	fibroblast growth factor receptor 1	Homo sapiens	57-62
30950230-5	2019	Here, the effects of lysine-deficient FGFR1 (FGFR1-29R lacking all 29 cytoplasmic lysine residues) or of only 15 lysine mutations (FGFR1-15R) on axon outgrowth and concomitant changes in signal pathway activation were investigated by immunocytochemistry and morphometry of cultured primary neurons.	Lysine	21-27	fibroblast growth factor receptor 1	Homo sapiens	38-43
30829415-9	2019	This determinant was also detected bound to lysines 195 and 475 of CLV-treated human serum albumin.	Lysine	44-51	albumin	Homo sapiens	91-98
31218788-0	2019	Evaluating the rumen-protected lysine stability in forage-based total mixed rations in vitro and determining the lysine Brix value.	Lysine	113-119	biogenesis of ribosomes BRX1	Homo sapiens	120-124
31218788-6	2019	Water LR% positively correlated with that from diets and with Brix values of Lys dissociated in water.	Lysine	77-80	biogenesis of ribosomes BRX1	Homo sapiens	62-66
31208706-5	2019	Interestingly, the addition of 6 lysine residues to the N-terminus of ApoEp (6KApoEp) directly inhibited apoE binding to N-terminal APP and markedly limited apoE- and ApoEp-mediated Abeta generation, presumably through decreasing APP cellular membrane trafficking and p44/42 mitogen-activated protein kinase phosphorylation.	Lysine	33-39	apolipoprotein E	Mus musculus	105-109
31208706-5	2019	Interestingly, the addition of 6 lysine residues to the N-terminus of ApoEp (6KApoEp) directly inhibited apoE binding to N-terminal APP and markedly limited apoE- and ApoEp-mediated Abeta generation, presumably through decreasing APP cellular membrane trafficking and p44/42 mitogen-activated protein kinase phosphorylation.	Lysine	33-39	apolipoprotein E	Mus musculus	157-161
31208706-5	2019	Interestingly, the addition of 6 lysine residues to the N-terminus of ApoEp (6KApoEp) directly inhibited apoE binding to N-terminal APP and markedly limited apoE- and ApoEp-mediated Abeta generation, presumably through decreasing APP cellular membrane trafficking and p44/42 mitogen-activated protein kinase phosphorylation.	Lysine	33-39	apolipoprotein E	Mus musculus	79-84
31264321-2	2019	We recently reported that a synthetic N-terminally biotinylated peptide, BP21, alleviates hypothermia and vascular hyperpermeability during anaphylactic reactions in a mouse model of anaphylaxis via the direct binding of a Tyr-Lys-Asp-Gly sequence in the peptide to PAF.	Lysine	227-231	BP21	Homo sapiens	73-77
31004702-1	2019	The zinc metalloprotease STAM-binding protein-like 1 (STAMBPL1) has been identified as a deubiquitinase by specifically cleaving Lys-63-linked polyubiquitin chains, but its cellular function remains unclear.	Lysine	129-132	STAM binding protein like 1	Homo sapiens	54-62
31039328-4	2019	TNF-alpha or IL-1beta stimulation reduced the expression of RNase1 relative to the acetylation state of histone 3 at lysine 27 and histone 4 of the RNASE1 promoter.	Lysine	117-123	tumor necrosis factor	Homo sapiens	0-9
31039328-4	2019	TNF-alpha or IL-1beta stimulation reduced the expression of RNase1 relative to the acetylation state of histone 3 at lysine 27 and histone 4 of the RNASE1 promoter.	Lysine	117-123	interleukin 1 beta	Homo sapiens	13-21
30793765-2	2019	Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone proteins and a heightened HDAC activation, notably of HDAC5, is associated with vascular disorders, such as atherosclerosis.	Lysine	74-80	histone deacetylase 5	Homo sapiens	170-175
30913789-3	2019	Here we introduce a novel poly-L-lysine (PLL) mediated nanobiosensor to detect Abeta in vitro.	Lysine	26-39	amyloid beta precursor protein	Homo sapiens	79-84
30793225-7	2019	GPNMB could upregulate the expression of Jumonji domain-containing protein 3 (Jmjd3), a histone 3 lysine 27 (H3K27) demethylase that is linked to the modulation of the inflammatory response and apoptosis.	Lysine	98-104	glycoprotein nmb	Homo sapiens	0-5
30205752-7	2019	We further found that Lys, Glu, Gln, Asn, and Arg residues shared the major contribution toward the intermolecular interactions in XPA homo-dimers.	Lysine	22-25	XPA, DNA damage recognition and repair factor	Homo sapiens	131-134
31160341-6	2019	We noted that coordination of the acceptor lysine leads to remodeling of amino acid side-chain interactions between the UBE2E1 active site and the E2-E3 direct interface, including the so-called "linchpin" residue conserved in RING E3s and required for ubiquitination.	Lysine	43-49	ubiquitin conjugating enzyme E2 E1	Homo sapiens	120-126
31460422-4	2019	This approach was validated by conjugation of an anionic derivative of the tubulin-binding cytotoxin colchinol methyl ether to lysine residues of the HER2-targeting antibody trastuzumab (Herceptin) via a disulfide.	Lysine	127-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-154
31358728-5	2019	Importantly, lysine 152 (K152) within the Src homology 2 (SH2) domain of c-Src is involved in RACK1 binding.	Lysine	13-19	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-78
31370222-6	2019	Using mass spectrometry, we identified lysine-3 as the major ubiquitylation site in the epsin plasma membrane binding domain.	Lysine	39-45	epsin	Saccharomyces cerevisiae S288C	88-93
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	72-75	ring finger protein 34	Homo sapiens	10-15
31350389-3	2019	Here we show that the deficiency of Setd2, a histone methyltransferase that catalyzes lysine 36 trimethylation on histone 3 (H3K36me3) in mice, causes a severe developmental block of thymocytes at the CD4-CD8- DN3 stage.	Lysine	86-92	SET domain containing 2	Mus musculus	36-41
31403616-7	2019	We illustrate these reactions using minimal components of the mouse Polycomb Repressive Complex 1 (PRC1), BMI1, and RING1B, an E3 ubiquitin ligase that monoubiquitinates histone H2A on lysine 119.	Lysine	185-191	Bmi1 polycomb ring finger oncogene	Mus musculus	106-110
31160341-0	2019	E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.	Lysine	44-50	tripartite motif containing 21	Homo sapiens	28-34
31160341-0	2019	E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.	Lysine	44-50	ubiquitin conjugating enzyme E2 E1	Homo sapiens	62-68
31160341-3	2019	We here report a 2.82-A crystal structure of the human TRIM21 RING domain in complex with the human E2-conjugating UBE2E1 enzyme, in which a ubiquitin-targeted TRIM21 substrate lysine was captured in the UBE2E1 active site.	Lysine	177-183	tripartite motif containing 21	Homo sapiens	55-61
31160341-3	2019	We here report a 2.82-A crystal structure of the human TRIM21 RING domain in complex with the human E2-conjugating UBE2E1 enzyme, in which a ubiquitin-targeted TRIM21 substrate lysine was captured in the UBE2E1 active site.	Lysine	177-183	ubiquitin conjugating enzyme E2 E1	Homo sapiens	115-121
31160341-3	2019	We here report a 2.82-A crystal structure of the human TRIM21 RING domain in complex with the human E2-conjugating UBE2E1 enzyme, in which a ubiquitin-targeted TRIM21 substrate lysine was captured in the UBE2E1 active site.	Lysine	177-183	tripartite motif containing 21	Homo sapiens	160-166
31160341-3	2019	We here report a 2.82-A crystal structure of the human TRIM21 RING domain in complex with the human E2-conjugating UBE2E1 enzyme, in which a ubiquitin-targeted TRIM21 substrate lysine was captured in the UBE2E1 active site.	Lysine	177-183	ubiquitin conjugating enzyme E2 E1	Homo sapiens	204-210
31160341-5	2019	In agreement, we found that critical UBE2E1 residues involved in the capture of the TRIM21 substrate lysine are conserved in ubiquitin-conjugating E2s, whereas residues critical for SUMOylation are not conserved.	Lysine	101-107	ubiquitin conjugating enzyme E2 E1	Homo sapiens	37-43
31160341-5	2019	In agreement, we found that critical UBE2E1 residues involved in the capture of the TRIM21 substrate lysine are conserved in ubiquitin-conjugating E2s, whereas residues critical for SUMOylation are not conserved.	Lysine	101-107	tripartite motif containing 21	Homo sapiens	84-90
31246453-2	2019	Neolymphostin A was recently shown to strongly inhibit phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) in a covalent manner via conjugation to a catalytic lysine residue in the ATP-binding pocket of the enzymes, making this metabolite the first reported covalent kinase inhibitor from a bacterium.	Lysine	185-191	mechanistic target of rapamycin kinase	Homo sapiens	127-131
31360909-1	2019	WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation.	Lysine	146-152	WD repeat domain 5	Homo sapiens	0-4
31304625-6	2019	Specifically, RNF34 initiates the K63- to K27-linked ubiquitination transition on MAVS primarily at Lys 311, which facilitates the autophagic degradation of MAVS upon RIG-I stimulation.	Lysine	100-103	ring finger protein 34	Homo sapiens	14-19
31354448-3	2019	In rodents, acute restraint stress increases the expression of the repressive histone H3 lysine 9 tri-methylation (H3K9me3) in hippocampal fields, including the CA3 pyramidal neurons.	Lysine	89-95	carbonic anhydrase 3	Mus musculus	161-164
31142615-4	2019	We provide evidence that the lysine residues at positions 6 and 8 of ERGIC3 are the major sites of MARCH2-mediated ubiquitination.	Lysine	29-35	membrane associated ring-CH-type finger 2	Homo sapiens	99-105
31367252-8	2019	Further mechanistic investigations showed that CDYL recruits the enhancer of zeste homolog 2 (EZH2) to regulate trimethylation of lysine 27 in histone 3 (H3K27me3) at the CDKN1C promoter region and promotes transcriptional silencing.	Lysine	130-136	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-92
30930352-2	2019	Sufficient detection of the mast cells was achieved by covalent immobilization of gelatin firstly on the sensor surface and followed by covalent binding of the anti-c-Kit antibody to lysine residues in the gelatin molecules through bis(sulfosuccinimidyl)suberate (BS3) treatment.	Lysine	183-189	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	165-170
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	cadherin 1	Homo sapiens	31-41
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	cadherin 1	Homo sapiens	94-104
30930352-3	2019	By using BS3, which is a homo-bifunctional reagent, the lysine residues of the anti-c-Kit antibody easily bound to the lysine residues of the gelatin in the physiological condition.	Lysine	56-62	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	84-89
30930352-3	2019	By using BS3, which is a homo-bifunctional reagent, the lysine residues of the anti-c-Kit antibody easily bound to the lysine residues of the gelatin in the physiological condition.	Lysine	119-125	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	84-89
31367252-8	2019	Further mechanistic investigations showed that CDYL recruits the enhancer of zeste homolog 2 (EZH2) to regulate trimethylation of lysine 27 in histone 3 (H3K27me3) at the CDKN1C promoter region and promotes transcriptional silencing.	Lysine	130-136	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	94-98
31367252-8	2019	Further mechanistic investigations showed that CDYL recruits the enhancer of zeste homolog 2 (EZH2) to regulate trimethylation of lysine 27 in histone 3 (H3K27me3) at the CDKN1C promoter region and promotes transcriptional silencing.	Lysine	130-136	cyclin dependent kinase inhibitor 1C	Homo sapiens	171-177
31334110-7	2019	Mechanistically, LNMAT1 epigenetically suppressed CADM1 expression by recruiting EZH2, the key regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), to the CADM1 promoter, resulting in transcriptional inhibition of CADM1.	Lysine	140-146	cell adhesion molecule 1	Homo sapiens	50-55
31371982-7	2019	The LDHA activity of HEK293T cells was detected under conditions of Lys-trimethylation inhibition, and the proliferation of HEK293T cells was measured using EdU and Western blotting analyses.	Lysine	68-71	lactate dehydrogenase A	Homo sapiens	4-8
31371982-9	2019	In particular, lactate dehydrogenase A (LDHA) was Lys-trimethylated on lysine (K5).	Lysine	71-77	lactate dehydrogenase A	Homo sapiens	15-38
31371982-9	2019	In particular, lactate dehydrogenase A (LDHA) was Lys-trimethylated on lysine (K5).	Lysine	71-77	lactate dehydrogenase A	Homo sapiens	40-44
31371982-11	2019	Conclusion: We suggested that LDHA affects the metabolism and proliferation of cells via a Lys-trimethylation-mediated mechanism; Lys-trimethylation might be a potential target for therapeutic research or used as a prognostic and treatment biomarker of several diseases.	Lysine	91-94	lactate dehydrogenase A	Homo sapiens	30-34
31371982-11	2019	Conclusion: We suggested that LDHA affects the metabolism and proliferation of cells via a Lys-trimethylation-mediated mechanism; Lys-trimethylation might be a potential target for therapeutic research or used as a prognostic and treatment biomarker of several diseases.	Lysine	130-133	lactate dehydrogenase A	Homo sapiens	30-34
31334110-7	2019	Mechanistically, LNMAT1 epigenetically suppressed CADM1 expression by recruiting EZH2, the key regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), to the CADM1 promoter, resulting in transcriptional inhibition of CADM1.	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	81-85
30387148-1	2019	Lysyl oxidase-like 2 (LOXL2) belongs to the family of lysyl oxidases, and as such promotes crosslinking of collagens and elastin by oxidative deamination of lysine residues.	Lysine	157-163	lysyl oxidase like 2	Homo sapiens	0-20
31266852-4	2019	Knockdown of the lncRNA Neat1 revealed widespread changes in gene transcription, as well as perturbations of histone 3 lysine 9 dimethylation (H3K9me2), a repressive histone modification mark that was increased in the hippocampus of aging rodents.	Lysine	119-125	nuclear paraspeckle assembly transcript 1 (non-protein coding)	Mus musculus	24-29
31266503-2	2019	Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues.	Lysine	183-189	bromodomain containing 4	Homo sapiens	59-63
30686098-4	2019	Here we report that UVRAG is ubiquitinated by SMURF1 at lysine residues 517 and 559, which decreases the association of UVRAG with RUBCN and promotes autophagosome maturation.	Lysine	56-62	UV radiation resistance associated	Homo sapiens	20-25
30686098-4	2019	Here we report that UVRAG is ubiquitinated by SMURF1 at lysine residues 517 and 559, which decreases the association of UVRAG with RUBCN and promotes autophagosome maturation.	Lysine	56-62	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	46-52
30686098-4	2019	Here we report that UVRAG is ubiquitinated by SMURF1 at lysine residues 517 and 559, which decreases the association of UVRAG with RUBCN and promotes autophagosome maturation.	Lysine	56-62	UV radiation resistance associated	Homo sapiens	120-125
30686098-8	2019	Importantly, we provide in vitro and in vivo evidence that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth.	Lysine	83-89	UV radiation resistance associated	Homo sapiens	59-64
31079532-8	2019	Infusion of either form of renin together with lysine markedly increased urinary renin such that it was no longer different between nondiabetic and diabetic mice.	Lysine	47-53	renin	Homo sapiens	81-86
30965074-0	2019	Prevention of alpha-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract formation in the diabetic rat.	Lysine	63-71	catalase	Rattus norvegicus	110-118
30965074-8	2019	After Lys treatment, CAT, superoxide dismutase, aldose reductase and other biochemical parameters in the lens and serum of the diabetic rats returned to the normal value.	Lysine	6-9	catalase	Rattus norvegicus	21-24
30965074-10	2019	The glycated alpha-crystallin lost its chaperone activity against heat denatured-CAT, but in the presence of Lys, it preserved its activity and prevented CAT aggregation.	Lysine	109-112	catalase	Rattus norvegicus	154-157
30387148-1	2019	Lysyl oxidase-like 2 (LOXL2) belongs to the family of lysyl oxidases, and as such promotes crosslinking of collagens and elastin by oxidative deamination of lysine residues.	Lysine	157-163	lysyl oxidase like 2	Homo sapiens	22-27
31068428-8	2019	However, alteration of Q428 to an arginine or lysine resulted in markedly greater resistance to eCD4-Ig and CD4-Ig, with correspondingly dramatic losses in infectivity and greater sensitivity to a V3 antibody and to serum from an infected individual.	Lysine	46-52	CD4 molecule	Homo sapiens	97-100
30854739-5	2019	This transcriptional activation of TIMP-3 was associated with the decrease in the expression of both enhancers of zeste homolog 2 (EZH2) and its catalytic product trimethylation of histone H3 at lysine 27 (H3K27me3) repressive marks at the TIMP-3 promoter with an accompanying increase in histone H3K9/18 acetylation.	Lysine	195-201	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	101-129
30854739-5	2019	This transcriptional activation of TIMP-3 was associated with the decrease in the expression of both enhancers of zeste homolog 2 (EZH2) and its catalytic product trimethylation of histone H3 at lysine 27 (H3K27me3) repressive marks at the TIMP-3 promoter with an accompanying increase in histone H3K9/18 acetylation.	Lysine	195-201	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	131-135
31067149-5	2019	Lysine residues within the transmembrane domain of Snc1 are necessary for presentation of a Snx4-Atg20-dependent sorting signal located within its juxtamembrane region.	Lysine	0-6	Snx4p	Saccharomyces cerevisiae S288C	92-96
31067149-7	2019	Degradative sorting requires lysine residues in the juxtamembrane region of Snc1 and is mediated by the Rsp5 ubiquitin ligase and its transmembrane adapters, Ear1 and Ssh4, which localize to endosome and vacuole membranes.	Lysine	29-35	Ssh4p	Saccharomyces cerevisiae S288C	167-171
31068455-6	2019	KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of WUS This multi-step silencing of WUS leads to the termination of floral stem cells, ensuring proper carpel development.	Lysine	186-192	Homeodomain-like superfamily protein	Arabidopsis thaliana	235-238
31068455-6	2019	KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of WUS This multi-step silencing of WUS leads to the termination of floral stem cells, ensuring proper carpel development.	Lysine	186-192	Homeodomain-like superfamily protein	Arabidopsis thaliana	268-271
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Lysine	258-264	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	106-110
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Lysine	318-324	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	106-110
31018989-8	2019	Insulin treatment increases alpha-tubulin Lysine 40 acetylation, a mechanism that was observed to be regulated by a counterbalance between GSK3 and mTOR, and led to microtubule stabilization.	Lysine	42-48	insulin	Homo sapiens	0-7
31018989-8	2019	Insulin treatment increases alpha-tubulin Lysine 40 acetylation, a mechanism that was observed to be regulated by a counterbalance between GSK3 and mTOR, and led to microtubule stabilization.	Lysine	42-48	mechanistic target of rapamycin kinase	Homo sapiens	148-152
31125786-9	2019	Our results suggest that SUMOylation of Csk mainly at lysine 53 negatively modulates its tumor suppressor function by reducing its binding with Cbp and consequently, inducing c-Src activation.	Lysine	54-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	175-180
31118275-0	2019	Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3.	Lysine	21-24	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3	Mus musculus	142-149
31253781-1	2019	SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer.	Lysine	60-66	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	0-6
31253781-1	2019	SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer.	Lysine	60-66	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	10-14
31174423-0	2019	Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.	Lysine	0-6	fatty acid-binding protein 5	Bos taurus	89-94
31247000-6	2019	Rapamycin and Ly-294,002 increased PDK4 mRNA expression in both cell lines but significance was only reached in U87.	Lysine	14-16	pyruvate dehydrogenase kinase 4	Homo sapiens	35-39
31174423-4	2019	Lys enhances FA-induced sterol regulatory element binding protein 1c (SREBP-1c) expression and maturation in a fatty-acid-binding protein 5 (FABP5)-dependent manner.	Lysine	0-3	fatty acid-binding protein 5	Bos taurus	111-139
31174423-4	2019	Lys enhances FA-induced sterol regulatory element binding protein 1c (SREBP-1c) expression and maturation in a fatty-acid-binding protein 5 (FABP5)-dependent manner.	Lysine	0-3	fatty acid-binding protein 5	Bos taurus	141-146
31174423-7	2019	In summary, our data reveals that Lys enhances FAs-stimulated SREBP-1c expression and maturation leading to milk fat synthesis via the GPRC6A-PI3K-FABP5 signaling in BMECs.	Lysine	34-37	fatty acid-binding protein 5	Bos taurus	147-152
30981630-0	2019	Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.	Lysine	53-59	DOT1 like histone lysine methyltransferase	Homo sapiens	20-25
31216749-6	2019	These processes were mediated by acetylation of lysine 9 of histone 3, resulting in upregulation involving Adenosine 5"-monophosphate (AMP)-activated protein kinase (APMK) phosphorylation and translocation of Nrf2 to the nucleus.	Lysine	48-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	209-213
30981630-2	2019	The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the detailed mechanism is not understood.	Lysine	77-83	DOT1 like histone lysine methyltransferase	Homo sapiens	16-21
31171769-6	2019	In addition, we revealed that miR-708 was transcriptionally repressed by EZH2 (enhancer of zeste homolog 2)-induced histone H3 lysine 27 trimethylation and promoter methylation.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77
31171769-6	2019	In addition, we revealed that miR-708 was transcriptionally repressed by EZH2 (enhancer of zeste homolog 2)-induced histone H3 lysine 27 trimethylation and promoter methylation.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	79-106
31068376-5	2019	Exposing neurons to MAG and CSPGs decreases acetylation of Miro1 on Lysine 105 (K105) and decreases axonal mitochondrial transport.	Lysine	68-74	ras homolog family member T1	Homo sapiens	59-64
31173720-1	2019	Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination.	Lysine	154-160	DOT1 like histone lysine methyltransferase	Homo sapiens	22-27
31173720-1	2019	Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination.	Lysine	154-160	DOT1 like histone lysine methyltransferase	Homo sapiens	124-129
30976763-2	2019	Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA).	Lysine	6-9	albumin	Homo sapiens	121-134
31160593-1	2019	Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27 (H3K27Me3) is critical for immune regulation.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
31160593-1	2019	Enhancer of zeste homolog 2 (EZH2)-mediated trimethylation of histone 3 lysine 27 (H3K27Me3) is critical for immune regulation.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
30804456-3	2019	Here we show that the IL-6/STAT3 inflammatory signaling axis induces the deacetylation of FRA1 at the Lys-116 residue located within its DNA-binding domain.	Lysine	102-105	interleukin 6	Homo sapiens	22-26
30082770-7	2019	Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPARgamma.	Lysine	0-6	peroxisome proliferator activated receptor gamma	Homo sapiens	130-139
30987999-7	2019	Mutation of the putative c-Jun acetylation site at lysine 273 increased transcriptional activation of c-Jun in melanoma cells and conveyed resistance to BRAF inhibition.	Lysine	51-57	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	153-157
30940696-10	2019	Exposure of colorectal carcinoma cells to the MGL-BL929 reduced methyl-CpG levels of hypermethylated gene promoters including that of CDKN2A, whose mRNA expression was increased, together with a decrease in global histone H3 dimethyl lysine 9.	Lysine	234-240	cyclin dependent kinase inhibitor 2A	Homo sapiens	134-140
30804456-3	2019	Here we show that the IL-6/STAT3 inflammatory signaling axis induces the deacetylation of FRA1 at the Lys-116 residue located within its DNA-binding domain.	Lysine	102-105	signal transducer and activator of transcription 3	Homo sapiens	27-32
30892634-3	2019	In murine myeloid progenitors, we decipher a new role for PLZF in restraining active genes and enhancers by targeting acetylated lysine 27 of Histone H3 (H3K27ac).	Lysine	129-135	zinc finger and BTB domain containing 16	Mus musculus	58-62
30716535-10	2019	The Clock mutation significantly inhibited the total lysine acetylation level in cartilage and inhibited NFkappaB acetylation at the Lys310 residue but promoted phosphorylation at the Ser276 residue.	Lysine	53-59	circadian locomotor output cycles kaput	Mus musculus	4-9
30716535-10	2019	The Clock mutation significantly inhibited the total lysine acetylation level in cartilage and inhibited NFkappaB acetylation at the Lys310 residue but promoted phosphorylation at the Ser276 residue.	Lysine	53-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-113
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	calcitonin related polypeptide alpha	Homo sapiens	207-211
31118464-15	2019	LASER knock-down enhance LSD1 targeting to genomic loci, resulting in decreased histone H3 lysine 4 mono-methylation at the promoter regions of HNF-1alpha gene.	Lysine	91-97	HNF1 homeobox A	Homo sapiens	144-154
30952377-1	2019	EZH2 is a core component of the polycomb repressive complex 2 (PRC2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and promotes carcinogenesis by epigenetically silencing many tumor suppressor genes.	Lysine	115-121	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
31135381-3	2019	Here, we report that calcineurin A (CNA), encoded by PPP3CB or PPP3CC, is constitutively ubiquitinated on lysine 327, and this polyubiquitin chain is rapidly removed by ubiquitin carboxyl-terminal hydrolase 16 (USP16) in response to intracellular calcium stimulation.	Lysine	106-112	protein phosphatase 3, catalytic subunit, beta isoform	Mus musculus	53-59
31112687-2	2019	A new study reveals that a complex between lysine-acetylated actin and cyclase-associated protein inhibits the formin INF2 by enhancing intramolecular inhibitory interactions in this protein.	Lysine	43-49	inverted formin 2	Homo sapiens	118-122
30916939-9	2019	Similarly, the rate constants describing nucleophilic attack by the lysine and methylated lysine analogues on beta-2"-fluoro-N7-methyl-2"-deoxyguanosine to form DNA-protein cross-links are also within experimental error of one another.	Lysine	68-74	glycoprotein hormone subunit alpha 2	Homo sapiens	110-116
30916939-9	2019	Similarly, the rate constants describing nucleophilic attack by the lysine and methylated lysine analogues on beta-2"-fluoro-N7-methyl-2"-deoxyguanosine to form DNA-protein cross-links are also within experimental error of one another.	Lysine	90-96	glycoprotein hormone subunit alpha 2	Homo sapiens	110-116
30914478-9	2019	We noted that, unlike bbZIP, human ZIP2 is predicted to harbor a single divalent metal-binding site, with the charged side chain of Lys-203 replacing the second bound ion.	Lysine	132-135	solute carrier family 39 member 2	Homo sapiens	35-39
30951287-2	2019	Disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, plays an important role in the progressions of mixed-lineage leukemia (MLL)-rearranged leukemias and has been validated as a potential therapeutic target.	Lysine	62-68	DOT1 like histone lysine methyltransferase	Homo sapiens	0-39
30951287-2	2019	Disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, plays an important role in the progressions of mixed-lineage leukemia (MLL)-rearranged leukemias and has been validated as a potential therapeutic target.	Lysine	62-68	DOT1 like histone lysine methyltransferase	Homo sapiens	41-46
31080522-8	2019	Mutation of 7 non-identical lysine residues is sufficient to make the resulting ORF1p to be predominantly cytoplasmic, demonstrating intrinsic redundancy of this requirement.	Lysine	28-34	ORF1	Homo sapiens	80-85
30877109-6	2019	Increased association of polyubiquitinated DDX17 with p300-YAP resulted in histone 3 lysine 56 (H3K56) acetylation proximal to stemness-related genes and their subsequent transcriptional activation.	Lysine	85-91	DEAD-box helicase 17	Homo sapiens	43-48
31009566-1	2019	Here, we present the synthesis and characterization of a new potentially nonadentate chelator H4pypa and its bifunctional analogue tBu4pypa-C7-NHS conjugated to prostate-specific membrane antigen (PSMA)-targeting peptidomimetic (Glu-urea-Lys).	Lysine	238-241	folate hydrolase 1	Homo sapiens	161-195
31009566-1	2019	Here, we present the synthesis and characterization of a new potentially nonadentate chelator H4pypa and its bifunctional analogue tBu4pypa-C7-NHS conjugated to prostate-specific membrane antigen (PSMA)-targeting peptidomimetic (Glu-urea-Lys).	Lysine	238-241	folate hydrolase 1	Homo sapiens	197-201
30946839-0	2019	Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16.	Lysine	132-138	mitogen-activated protein kinase 3	Homo sapiens	19-25
31123462-13	2019	Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.	Lysine	85-91	interferon gamma	Homo sapiens	202-211
30894089-10	2019	Mechanistically, SIRT6 induced the expression of GATA5 (GATA-binding protein 5), a novel regulator of blood pressure, through inhibiting Nkx3.2 (NK3 homeobox 2) transcription by deacetylating histone H3K9 (histone H3 lysine 9), thereby regulating GATA5-mediated signaling pathways to prevent endothelial injury.	Lysine	217-223	sirtuin 6	Mus musculus	17-22
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	123-129	Arr3p	Saccharomyces cerevisiae S288C	25-29
30986070-0	2019	alpha-Selective Lysine Ligation and Application in Chemical Synthesis of Interferon Gamma.	Lysine	16-22	interferon gamma	Homo sapiens	73-89
30886050-6	2019	We further determined that FOXP3 undergoes K63-linked ubiquitination at lysine 262 mediated by the E3 ligase TRAF6.	Lysine	72-78	TNF receptor-associated factor 6	Mus musculus	109-114
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	123-129	Arr3p	Saccharomyces cerevisiae S288C	106-110
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	143-149	Arr3p	Saccharomyces cerevisiae S288C	25-29
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	143-149	Arr3p	Saccharomyces cerevisiae S288C	106-110
30780018-1	2019	Bromodomain PHD finger transcription factor (BPTF), a bromodomain-containing protein, plays a crucial role in the regulation of downstream gene expression through the specific recognition of lysine acetylation on bulk histones.	Lysine	191-197	bromodomain PHD finger transcription factor	Homo sapiens	45-49
30780018-1	2019	Bromodomain PHD finger transcription factor (BPTF), a bromodomain-containing protein, plays a crucial role in the regulation of downstream gene expression through the specific recognition of lysine acetylation on bulk histones.	Lysine	191-197	bromodomain PHD finger transcription factor	Homo sapiens	0-43
30951900-0	2019	Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1alpha-dependent pathway.	Lysine	14-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
31050579-0	2019	Fine-tuning AKT kinase activity through direct lysine methylation.	Lysine	47-53	AKT serine/threonine kinase 1	Homo sapiens	12-15
30893641-6	2019	As a proved transcription factor of FGF21, the expression of CREBH was initiated by MS-275, with increased Histone H3 Lysine 18 acetylation(H3K18ac) signals and hepatocyte nuclear factor 4 alpha (HNF-4alpha) recruitment in CREBH promoter.	Lysine	118-124	fibroblast growth factor 21	Homo sapiens	36-41
30565859-1	2019	Bromodomain-containing protein 4 (BRD4) recognizes the acetylated lysine of histone H4 via its bromodomains, leading to the recruitment of positive transcription elongation factor b.	Lysine	66-72	bromodomain containing 4	Homo sapiens	0-32
30565859-1	2019	Bromodomain-containing protein 4 (BRD4) recognizes the acetylated lysine of histone H4 via its bromodomains, leading to the recruitment of positive transcription elongation factor b.	Lysine	66-72	bromodomain containing 4	Homo sapiens	34-38
30962627-6	2019	CBP/EP300 bromodomain inhibition decreases somatic-specific gene expression, histone H3 lysine 27 acetylation (H3K27Ac) and chromatin accessibility at target promoters and enhancers.	Lysine	88-94	CREB binding protein	Homo sapiens	0-3
31080350-13	2019	Our results suggest that the three residues, Lys-554, His-594, and Glu-598, in TRPC5 might be responsible for direct interaction with EA, inducing the channel activation.	Lysine	45-48	transient receptor potential cation channel subfamily C member 5	Homo sapiens	79-84
31179409-0	2019	Identification of Specific Lysines and Arginines That Mediate Angiomotin Membrane Association.	Lysine	27-34	angiomotin	Homo sapiens	62-72
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	toll like receptor 7	Homo sapiens	229-256
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	toll like receptor 7	Homo sapiens	258-264
31015455-3	2019	Here, we report that in response to proinflammatory cytokines, BRAF is subjected to lysine 27-linked poly-ubiquitination in melanoma cells by the ITCH ubiquitin E3 ligase.	Lysine	84-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	63-67
31024026-3	2019	Polycomb repressive complex 2 (PRC2), which contains core subunits (EZH2, EED, and SUZ12), regulates gene activity by trimethylation of histone 3 lysine 27.	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	68-72
31139703-1	2019	Polycomb group protein EZH2, a histone methyltransferase, is the enzymatic subunit of the Polycomb Repressive Complex 2 (PRC2) that catalyzes histone H3 lysine 27 methylation.	Lysine	153-159	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	23-27
30967505-1	2019	Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2), the enzyme that catalyzes monomethylation, dimethylation, and trimethylation of lysine 27 on histone H3 (H3K27).	Lysine	180-186	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
30967505-1	2019	Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2), the enzyme that catalyzes monomethylation, dimethylation, and trimethylation of lysine 27 on histone H3 (H3K27).	Lysine	180-186	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
31015455-4	2019	Lysine 27-linked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inhibitory interaction with 14-3-3, leading to sustained BRAF activation and subsequent elevation of the MEK/ERK signaling.	Lysine	0-6	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	167-171
31015455-4	2019	Lysine 27-linked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inhibitory interaction with 14-3-3, leading to sustained BRAF activation and subsequent elevation of the MEK/ERK signaling.	Lysine	0-6	mitogen-activated protein kinase kinase 7	Homo sapiens	215-218
31015455-4	2019	Lysine 27-linked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inhibitory interaction with 14-3-3, leading to sustained BRAF activation and subsequent elevation of the MEK/ERK signaling.	Lysine	0-6	mitogen-activated protein kinase 1	Homo sapiens	219-222
31015495-3	2019	The PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 lysine 36 trimethylation (H3K36me3); however, the functionality of this interaction for DNMT3A remains untested in vivo.	Lysine	77-83	DNA methyltransferase 3A	Mus musculus	20-26
31015495-3	2019	The PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 lysine 36 trimethylation (H3K36me3); however, the functionality of this interaction for DNMT3A remains untested in vivo.	Lysine	77-83	DNA methyltransferase 3B	Mus musculus	31-37
31024250-3	2019	EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and trimethylation of lysine 27 of histone 3 (H3K27Me3), the chromatin mark associated with gene silencing.	Lysine	127-133	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
30649429-3	2019	Here, using biochemically defined assays employing purified factors and cell-based analyses, we demonstrate that RNF20/40, in conjunction with its cognate E2 ubiquitin-conjugating enzyme RAD6, monoubiquitylates lysine 381 of eEF1BdeltaL, a heat shock transcription factor.	Lysine	211-217	ring finger protein 20	Homo sapiens	113-118
30990809-6	2019	RESULTS: We identified KMT2D, SETD1A and SETD2, included in the lysine methyltransferase activity function, as linked with poor prognosis in invasive breast cancer.	Lysine	64-70	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	30-36
31011633-0	2019	Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency.	Lysine	19-25	NLR family pyrin domain containing 3	Homo sapiens	65-70
31011633-1	2019	Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway.	Lysine	0-6	NLR family pyrin domain containing 3	Homo sapiens	186-191
30976011-2	2019	PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1).	Lysine	96-102	protein regulator of cytokinesis 1	Mus musculus	57-61
31015455-3	2019	Here, we report that in response to proinflammatory cytokines, BRAF is subjected to lysine 27-linked poly-ubiquitination in melanoma cells by the ITCH ubiquitin E3 ligase.	Lysine	84-90	itchy E3 ubiquitin protein ligase	Homo sapiens	146-150
31015455-4	2019	Lysine 27-linked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inhibitory interaction with 14-3-3, leading to sustained BRAF activation and subsequent elevation of the MEK/ERK signaling.	Lysine	0-6	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	35-39
30795863-3	2019	Guided by the dCas9/sgRNA-PP7, the PCP-EZH2 can specifically target gene loci to catalyze 3 methylation of histone H3 lysine 27, resulting in the inhibition of gene expression.	Lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	39-43
30949841-0	2019	Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in E. coli.	Lysine	18-24	insulin	Homo sapiens	80-87
30949841-3	2019	RESULTS: The misincorporated lysine (Lys) at asparagine (Asn) position A21 was detected in recombinant human insulin and its analogs.	Lysine	29-35	insulin	Homo sapiens	109-116
30949841-3	2019	RESULTS: The misincorporated lysine (Lys) at asparagine (Asn) position A21 was detected in recombinant human insulin and its analogs.	Lysine	37-40	insulin	Homo sapiens	109-116
30799082-10	2019	We predicted through UCSC database and validated by ChIP assay that EZH2, a crucial regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), bound to CPEB3 promoter.	Lysine	129-135	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	68-72
30291962-4	2019	We investigated the role of a lysine-rich sequence (KKK653-655) 20 amino acids upstream of the C-terminus unique to 5-LOX that might displace the main-chain carboxylate in the iron coordination sphere.	Lysine	30-36	arachidonate 5-lipoxygenase	Homo sapiens	116-121
30623565-4	2019	Based on the reported prerequisite role of nucleolar stress response in stress-induced p53 protein accumulation, we have also provided evidence suggesting that Sirt1-mediated inhibition on nucleolar stress response may represent a novel mechanism by which Sirt1 can modulate intracellular p53 accumulation independent of lysine deacetylation.	Lysine	321-327	tumor protein p53	Homo sapiens	87-90
30623565-4	2019	Based on the reported prerequisite role of nucleolar stress response in stress-induced p53 protein accumulation, we have also provided evidence suggesting that Sirt1-mediated inhibition on nucleolar stress response may represent a novel mechanism by which Sirt1 can modulate intracellular p53 accumulation independent of lysine deacetylation.	Lysine	321-327	tumor protein p53	Homo sapiens	289-292
30683654-3	2019	Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest.	Lysine	263-266	transforming growth factor beta 1	Homo sapiens	14-21
30683654-3	2019	Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest.	Lysine	263-266	mitogen-activated protein kinase 14	Homo sapiens	30-33
30683654-3	2019	Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest.	Lysine	263-266	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	93-96
30710320-6	2019	As expected, SSE altered the histone (H3) lysine (K14/K9) acetylation (ac) and H3K4/K9 methylation (me2/me3).	Lysine	42-48	keratin 9	Rattus norvegicus	54-83
30683654-3	2019	Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest.	Lysine	263-266	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	112-122
30683654-3	2019	Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest.	Lysine	263-266	tumor protein p53	Homo sapiens	124-127
30881498-6	2019	Furthermore, treating cells with resveratrol upregulated SET domain containing lysine methyltransferase 7/9 (SET7/9) expression, which positively regulates p53 through its mono-methylation at lysine 372, compared with untreated cells.	Lysine	79-85	tumor protein p53	Homo sapiens	156-159
30710424-9	2019	The marked reduction in SIRT1 expression by combination of metformin and tenovin-6 increased acetylation of p53 at lysine 382 and enhanced p53 stability in LKB1-deficient A549 cells.	Lysine	115-121	tumor protein p53	Homo sapiens	108-111
30987726-10	2019	The nanoLC-MS/MS showed that the carbamylation of lysine 290 (K290) of PON-1, a residue adjacent to PON-1 activity determining site, was detected in uremic HDL but not detected in control HDL.	Lysine	50-56	paraoxonase 1	Homo sapiens	71-76
30987726-10	2019	The nanoLC-MS/MS showed that the carbamylation of lysine 290 (K290) of PON-1, a residue adjacent to PON-1 activity determining site, was detected in uremic HDL but not detected in control HDL.	Lysine	50-56	paraoxonase 1	Homo sapiens	100-105
30585695-3	2019	While BD2 has been found to bind acetylated histone H3 lysine 14 (H3K14ac), it is not known whether other BDs collaborate with BD2 to generate strong binding to H3K14ac, and the importance of H3K14ac recognition for the molecular and tumor suppressor function of PBRM1 is also unknown.	Lysine	55-61	defensin beta 4A	Homo sapiens	6-9
30560355-6	2019	Further, SAA could interact with the lysine residue 633 (K633) of GRP78, which inhibited GRP78 secretion.	Lysine	37-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	66-71
30560355-6	2019	Further, SAA could interact with the lysine residue 633 (K633) of GRP78, which inhibited GRP78 secretion.	Lysine	37-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	89-94
30846735-0	2019	Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.	Lysine	55-61	thymoma viral proto-oncogene 1	Mus musculus	73-76
30925159-7	2019	Finally, lysine residue 358 was the key site for p53 K63-linked ubiquitination by the N and P proteins.	Lysine	9-15	tumor protein p53	Homo sapiens	49-52
30718280-6	2019	This interaction strongly stimulated OTUB1 DUB activity toward Lys-48-linked diubiquitin.	Lysine	63-66	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	37-42
30718280-7	2019	Furthermore, the noncovalent interaction between FAT10 and OTUB1 not only enhanced its isopeptidase activity toward Lys-48-linked ubiquitin moieties but also strengthened its noncatalytic activity in reducing Lys-63 polyubiquitylation of its target protein TRAF3 (TNF receptor-associated factor 3).	Lysine	116-119	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	59-64
30718280-7	2019	Furthermore, the noncovalent interaction between FAT10 and OTUB1 not only enhanced its isopeptidase activity toward Lys-48-linked ubiquitin moieties but also strengthened its noncatalytic activity in reducing Lys-63 polyubiquitylation of its target protein TRAF3 (TNF receptor-associated factor 3).	Lysine	209-212	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	59-64
30923526-11	2019	Therefore, we provided evidence that, in the context of the full length C1q protein, a key contribution to the interaction with both PTX3 and IgM is given by the B chain Arg residues that line the side of the gC1q heterotrimer, with a minor participation of a Lys residue located at the apex of gC1q.	Lysine	260-263	pentraxin 3	Homo sapiens	133-137
30591525-5	2019	Here, we show that FXII-Lys/Arg309 is susceptible to cleavage after residue 309 by coagulation proteases (thrombin and FXIa), resulting in generation of a truncated form of FXII (deltaFXII).	Lysine	24-27	coagulation factor II, thrombin	Homo sapiens	106-114
30591525-8	2019	In mice given human FXII-Lys/Arg309, induction of thrombin generation by infusion of tissue factor results in enhanced HK cleavage as a consequence of deltaFXII formation.	Lysine	25-28	coagulation factor II, thrombin	Homo sapiens	50-58
30935091-6	2019	Studies of HDAC inhibitors (HDACi) in human neuronal cells show that HDAC6 inhibitors (HDAC6i) increase the acetylation of specific lysine residues in proteins involved in synaptogenesis.	Lysine	132-138	histone deacetylase 6	Homo sapiens	69-74
30826376-2	2019	The histone H3 lysine-27 (H3K27) mono-methyltransferase Arabidopsis trithorax-related protein 5/6 (ATXR5/6) associates with PCNA, and this interaction has been proposed to act as a key determinant controlling the reestablishment of H3K27 mono-methylation following replication.	Lysine	15-21	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	99-106
30710046-5	2019	We identified that changes in myeloid TLR4 during tissue repair correlated with increased expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL1), which specifically trimethylates the histone 3 lysine 4 (H3K4me3) position of the TLR4 promoter.	Lysine	215-221	toll-like receptor 4	Mus musculus	38-42
30710046-5	2019	We identified that changes in myeloid TLR4 during tissue repair correlated with increased expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL1), which specifically trimethylates the histone 3 lysine 4 (H3K4me3) position of the TLR4 promoter.	Lysine	215-221	lysine (K)-specific methyltransferase 2A	Mus musculus	135-159
30710046-5	2019	We identified that changes in myeloid TLR4 during tissue repair correlated with increased expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL1), which specifically trimethylates the histone 3 lysine 4 (H3K4me3) position of the TLR4 promoter.	Lysine	215-221	lysine (K)-specific methyltransferase 2A	Mus musculus	161-165
30710046-5	2019	We identified that changes in myeloid TLR4 during tissue repair correlated with increased expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL1), which specifically trimethylates the histone 3 lysine 4 (H3K4me3) position of the TLR4 promoter.	Lysine	215-221	toll-like receptor 4	Mus musculus	250-254
30857550-10	2019	The results indicated that RFX1 downregulation contributed to the decreased DNA methylation and histone H3 lysine 9 trimethylation and the increased H3 and H4 acetylation in the TLR4 promoter via the lack of recruitments of DNA methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), and histone-lysine N-methyltransferase SUV39H1 (SUV39H1), which were observed in CD14+ monocytes of CAD patients.	Lysine	107-113	regulatory factor X1	Homo sapiens	27-31
30849389-0	2019	Retraction Notice to: Methyl-CpG Binding Protein MBD1 Couples Histone H3 Methylation at Lysine 9 by SETDB1 to DNA Replication and Chromatin Assembly.	Lysine	88-94	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	100-106
30846735-1	2019	The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) and recruits the lysine methyltransferase, Setd2, to chromatin to regulate H3K36me3.	Lysine	142-148	SET domain containing 2	Mus musculus	168-173
30281815-11	2019	DDX5 overexpression decreased p62/TRAF6-mediated lysine 63-linked ubiquitination of mammalian target of rapamycin (mTOR) and subsequently inhibited the mTOR signaling pathway.	Lysine	49-55	mechanistic target of rapamycin kinase	Homo sapiens	84-113
30795871-5	2019	The residue Y113 of synaptobrevin-2 flexible region was mutated to lysine and glutamate.	Lysine	67-73	vesicle associated membrane protein 2	Homo sapiens	20-35
30842412-4	2019	Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1alpha-deficient plasmablasts.	Lysine	46-52	DDRGK domain containing 1	Homo sapiens	60-65
30842412-4	2019	Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1alpha-deficient plasmablasts.	Lysine	46-52	DDRGK domain containing 1	Homo sapiens	86-91
30842412-4	2019	Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1alpha-deficient plasmablasts.	Lysine	76-82	DDRGK domain containing 1	Homo sapiens	60-65
30842412-4	2019	Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1alpha-deficient plasmablasts.	Lysine	76-82	DDRGK domain containing 1	Homo sapiens	86-91
30599068-7	2019	Microtubule stabilization was accompanied by enhanced alpha-tubulin acetylation on lysine 40 and the depletion of HDAC6, the major deacetylase for alpha-tubulin lysine 40.	Lysine	161-167	histone deacetylase 6	Homo sapiens	114-119
30281815-11	2019	DDX5 overexpression decreased p62/TRAF6-mediated lysine 63-linked ubiquitination of mammalian target of rapamycin (mTOR) and subsequently inhibited the mTOR signaling pathway.	Lysine	49-55	mechanistic target of rapamycin kinase	Homo sapiens	115-119
30633952-0	2019	The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.	Lysine	15-18	snail family transcriptional repressor 1	Homo sapiens	127-132
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Lysine	42-45	transforming growth factor beta 1	Homo sapiens	107-115
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Lysine	42-45	inhibin subunit alpha	Homo sapiens	133-137
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Lysine	42-45	transforming growth factor beta 1	Homo sapiens	187-195
30469267-2	2019	Here we describe a novel nano-biosensor for Abeta mediated by poly-L-lysine (PLL) which was used for the amplification of detection signal for Abeta.	Lysine	62-75	amyloid beta precursor protein	Homo sapiens	44-49
30469267-2	2019	Here we describe a novel nano-biosensor for Abeta mediated by poly-L-lysine (PLL) which was used for the amplification of detection signal for Abeta.	Lysine	62-75	amyloid beta precursor protein	Homo sapiens	143-148
29987742-9	2019	Moreover, TNF-alpha expression inhibitors in combination with DEXA induced further HIV silencing and increased the histone 3 lysine 27 tri-methylated epigenetic mark of repression at the HIV promoter region.	Lysine	125-131	tumor necrosis factor	Homo sapiens	10-19
30598510-4	2019	The BGZP-C-binding site on InhA previously was reported to be located on the outside of the extended finger region, yet at the same time to include Ser-112 and Lys-119, homologous to TGF-beta2 Ile-92 and Lys-97, on the inside of the fingers.	Lysine	160-163	inhibin subunit alpha	Homo sapiens	27-31
30598510-4	2019	The BGZP-C-binding site on InhA previously was reported to be located on the outside of the extended finger region, yet at the same time to include Ser-112 and Lys-119, homologous to TGF-beta2 Ile-92 and Lys-97, on the inside of the fingers.	Lysine	204-207	inhibin subunit alpha	Homo sapiens	27-31
30633952-6	2019	KDM6B catalyzes the demethylation of histone H3 Lys 27 trimethylation (H3K27me3) in the promoter of SNAI1, which is important for SNAI1 upregulation.	Lysine	48-51	snail family transcriptional repressor 1	Homo sapiens	100-105
30633952-6	2019	KDM6B catalyzes the demethylation of histone H3 Lys 27 trimethylation (H3K27me3) in the promoter of SNAI1, which is important for SNAI1 upregulation.	Lysine	48-51	snail family transcriptional repressor 1	Homo sapiens	130-135
30624906-5	2019	The binding-guide lysine reactions were first examined on an SH3 domain and then tested on several ubiquitin-like proteins such as SUMO, Atg8 protein family, plant ATG8, and mammalian LC3 proteins that contain at least seven lysine residues on the surface.	Lysine	18-24	GABA type A receptor associated protein like 1	Homo sapiens	137-141
30535125-3	2019	However, lysine methylation of FOXO1 has not yet been identified.	Lysine	9-15	forkhead box O1	Homo sapiens	31-36
30823619-7	2019	As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively.	Lysine	50-56	RFI	Gallus gallus	127-130
30867746-6	2019	Mechanistically, stimulation by IL-6 and TNF-alpha induced the trimethylation of histone H3 lysine 4 (H3K4Me3) at the MASTL promoter to facilitate chromatin accessibility.	Lysine	92-98	interleukin 6	Homo sapiens	32-36
30867746-6	2019	Mechanistically, stimulation by IL-6 and TNF-alpha induced the trimethylation of histone H3 lysine 4 (H3K4Me3) at the MASTL promoter to facilitate chromatin accessibility.	Lysine	92-98	tumor necrosis factor	Homo sapiens	41-50
30755532-2	2019	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) mediates trimethylation of lysine 27 of histone 3 (H3K27me3), which acts as a repressive epigenetic mark.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
30624906-5	2019	The binding-guide lysine reactions were first examined on an SH3 domain and then tested on several ubiquitin-like proteins such as SUMO, Atg8 protein family, plant ATG8, and mammalian LC3 proteins that contain at least seven lysine residues on the surface.	Lysine	18-24	GABA type A receptor associated protein like 1	Homo sapiens	164-168
30899413-1	2019	DOT1-like protein (Dot1L) is the sole methyltransferase for methylation of lysine 79 in histone H3.	Lysine	75-81	DOT1 like histone lysine methyltransferase	Homo sapiens	0-17
30899413-1	2019	DOT1-like protein (Dot1L) is the sole methyltransferase for methylation of lysine 79 in histone H3.	Lysine	75-81	DOT1 like histone lysine methyltransferase	Homo sapiens	19-24
30541920-8	2019	In view of these results, we propose that autoinduced carbonylation, and thus removal of a positive charge in Lys, abrogates binding of cyt c to negatively charged CL.	Lysine	110-113	cytochrome c, somatic	Homo sapiens	136-141
30759380-3	2019	Dot1L activity is part of a trans-histone crosstalk pathway, requiring prior histone H2B ubiquitylation of lysine 120 (H2BK120ub) for optimal activity.	Lysine	107-113	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
30753822-1	2019	Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27).	Lysine	162-168	lysine demethylase 6A	Homo sapiens	67-70
30753822-1	2019	Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27).	Lysine	162-168	lysine demethylase 6A	Homo sapiens	83-88
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	99-126
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	128-132
29631413-6	2019	Augmented PPARalpha in hypertrophied myocytes revealed downregulated p53 acetylation (lys 382), leading to reduced apoptosis.	Lysine	86-89	tumor protein p53	Homo sapiens	69-72
30476793-5	2019	The results of DLS, TEM and MALDI-ToF studies demonstrated disaggregation of lysozyme (LYZ) aggregates in the presence of poly(FMA)-block-poly(NVP) and formation of the polyamphiphile...LYS complex possessing antibacterial action.	Lysine	186-189	lysozyme	Homo sapiens	77-85
30458214-5	2019	In addition, lysine 280 in WDR54, also in this WD domain, was an important residue for both cross-linking and ubiquitination.	Lysine	13-19	WD repeat domain 54	Homo sapiens	27-32
30518648-4	2019	Based on mass spectrometric analysis, Lys(664) of PA can be deacetylated by HDAC6, and the residue is crucial for PA protein stability.	Lysine	38-41	histone deacetylase 6	Homo sapiens	76-81
30476793-5	2019	The results of DLS, TEM and MALDI-ToF studies demonstrated disaggregation of lysozyme (LYZ) aggregates in the presence of poly(FMA)-block-poly(NVP) and formation of the polyamphiphile...LYS complex possessing antibacterial action.	Lysine	186-189	lysozyme	Homo sapiens	87-90
30692625-3	2019	Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its activation, which is antagonized by the Jumonji-family demethylase KDM4B.	Lysine	51-57	thymoma viral proto-oncogene 1	Mus musculus	21-24
30547679-8	2019	In terms of health outcomes, FTD/TPI was associated with 0.25 and 0.11 increment in LYs compared with BSC and regorafenib, respectively.	Lysine	84-87	triosephosphate isomerase 1	Homo sapiens	33-36
30136122-4	2019	Here, according to the method described by Gobinda, we synthesized a 16 lysine (K) residue-linked low-density lipoprotein receptor-related protein (LRP)-binding amino acid segment of apolipoprotein E (K16APoE).	Lysine	72-78	LDL receptor related protein 1	Homo sapiens	148-151
30136122-4	2019	Here, according to the method described by Gobinda, we synthesized a 16 lysine (K) residue-linked low-density lipoprotein receptor-related protein (LRP)-binding amino acid segment of apolipoprotein E (K16APoE).	Lysine	72-78	apolipoprotein E	Homo sapiens	183-199
30458637-2	2019	It has been demonstrated that SIRT3 plays a critical role in maintaining normal mitochondrial biological function through reversible protein lysine deacetylation.	Lysine	141-147	sirtuin 3	Homo sapiens	30-35
30516430-4	2019	Here, we show that periplakin is SUMOylated at a conserved lysine in its linker domain (K1646) preferentially by small ubiquitin-like modifier 1 (SUMO1).	Lysine	59-65	periplakin	Homo sapiens	19-29
30692625-3	2019	Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its activation, which is antagonized by the Jumonji-family demethylase KDM4B.	Lysine	51-57	SET domain, bifurcated 1	Mus musculus	35-41
30520161-1	2019	The ATPase family, AAA domain-containing protein 2 (ATAD2) has a C-terminal bromodomain, which functions as a chromatin reader domain recognizing acetylated lysine on the histone tails within the nucleosome.	Lysine	157-163	ATPase family AAA domain containing 2	Homo sapiens	4-50
30520161-1	2019	The ATPase family, AAA domain-containing protein 2 (ATAD2) has a C-terminal bromodomain, which functions as a chromatin reader domain recognizing acetylated lysine on the histone tails within the nucleosome.	Lysine	157-163	ATPase family AAA domain containing 2	Homo sapiens	52-57
30445466-6	2019	Depletion of RNF8 or expression of NONO with lysine to arginine substitutions at positions 279, 290 and 295 prolonged CHK1 phosphorylation over an extended period of time.	Lysine	45-51	checkpoint kinase 1	Homo sapiens	118-122
30975281-0	2019	[The 161th lysine of C/EBPalpha in alveolar type II epithelial cells is modified by small ubiquitin-related modification].	Lysine	11-17	CCAAT enhancer binding protein alpha	Homo sapiens	21-31
30975281-4	2019	The SUMO site of C/EBPalpha was predicted to be the 161st lysine (K161) by the SUMOsp software.	Lysine	58-64	CCAAT enhancer binding protein alpha	Homo sapiens	17-27
30975281-10	2019	These suggested that the SUMO site of C/EBPalpha was the 161st lysine.	Lysine	63-69	CCAAT enhancer binding protein alpha	Homo sapiens	38-48
30975281-11	2019	Conclusion C/EBPalpha can be modified by SUMO1 and the site of its modification is the 161st lysine in human AECII.	Lysine	93-99	CCAAT enhancer binding protein alpha	Homo sapiens	11-21
30359161-1	2019	Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC) and the histone methyl transferase DOT1L.	Lysine	99-105	DOT1 like histone lysine methyltransferase	Homo sapiens	285-290
31359993-7	2019	The binding interactions of this compound with the active site of NF-kappaB proteins suggested that amino acid residues (Lys52, Ser243, Asp274, Lys, 275) might play a key role in anti-breast cancer activity.	Lysine	121-124	nuclear factor kappa B subunit 1	Homo sapiens	66-75
30643005-3	2019	These characteristics are typically associated with regulation through chromatin acetylation by binding histone H3 trimethylated at lysine 4 (H3K4me3) and through transcriptional activity of transcription factor P53 and NF-kappaB.	Lysine	132-138	tumor protein p53	Homo sapiens	212-215
30699359-7	2019	This process antagonizes phosphorylation of FNIP1, preventing its interaction with Hsp90, and consequently promotes FNIP1 lysine-1119 ubiquitination and proteasomal degradation.	Lysine	122-128	folliculin interacting protein 1	Homo sapiens	44-49
30699359-7	2019	This process antagonizes phosphorylation of FNIP1, preventing its interaction with Hsp90, and consequently promotes FNIP1 lysine-1119 ubiquitination and proteasomal degradation.	Lysine	122-128	folliculin interacting protein 1	Homo sapiens	116-121
30677064-2	2019	The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of the Polycomb Repressive Complex 2 and is responsible for placing the histone H3 lysine 27 trimethylation (H3K27me3) repressive mark on the genome through its methyltransferase domain.	Lysine	153-159	enhancer of zeste 2 polycomb repressive complex 2 subunit	Danio rerio	16-43
30612740-2	2019	Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo.	Lysine	119-125	methyltransferase 13, eEF1A lysine and N-terminal methyltransferase	Homo sapiens	26-33
30612740-2	2019	Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo.	Lysine	119-125	methyltransferase 13, eEF1A lysine and N-terminal methyltransferase	Homo sapiens	35-60
30677064-2	2019	The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of the Polycomb Repressive Complex 2 and is responsible for placing the histone H3 lysine 27 trimethylation (H3K27me3) repressive mark on the genome through its methyltransferase domain.	Lysine	153-159	enhancer of zeste 2 polycomb repressive complex 2 subunit	Danio rerio	45-49
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	cullin 4A	Homo sapiens	123-132
30452037-2	2019	Reversible active site binding of electrophile bearing compounds enables susbsequent covalent reaction with a lysine residue (K408) in the flexible C-terminal region of PHD2 to give a modified protein that retains catalytic activity.	Lysine	110-116	egl-9 family hypoxia inducible factor 1	Homo sapiens	169-173
30622182-6	2019	Mechanistically, we found that during mitosis SETD6 binds and methylates PLK1 on two lysine residues: K209 and K413.	Lysine	85-91	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	46-51
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	cullin 4A	Homo sapiens	134-139
30669413-5	2019	One of the most well-studied events is monoubiquitination of histone H2B at lysine 120 (H2Bub1), written predominantly by the RING finger complex RNF20-RNF40 and generally associated with active transcription.	Lysine	76-82	ring finger protein 20	Homo sapiens	146-151
30659183-7	2019	Upon LPS stimulation, GAPDH undergoes malonylation on lysine 213, leading to its dissociation from TNFalpha mRNA, promoting translation.	Lysine	54-60	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	22-27
30659183-7	2019	Upon LPS stimulation, GAPDH undergoes malonylation on lysine 213, leading to its dissociation from TNFalpha mRNA, promoting translation.	Lysine	54-60	tumor necrosis factor	Homo sapiens	99-107
30659184-10	2019	Furthermore, HPIP potentiates the transcriptional activity of LEF1 and acetylates histone H3 lysine 56 in the promoters of Wnt targets, suggesting that HPIP is an attractive target in OA regulatory network.	Lysine	93-99	host cell factor C1 regulator 1 (XPO1-dependent)	Mus musculus	13-17
30659184-10	2019	Furthermore, HPIP potentiates the transcriptional activity of LEF1 and acetylates histone H3 lysine 56 in the promoters of Wnt targets, suggesting that HPIP is an attractive target in OA regulatory network.	Lysine	93-99	host cell factor C1 regulator 1 (XPO1-dependent)	Mus musculus	152-156
30669413-5	2019	One of the most well-studied events is monoubiquitination of histone H2B at lysine 120 (H2Bub1), written predominantly by the RING finger complex RNF20-RNF40 and generally associated with active transcription.	Lysine	76-82	ring finger protein 40	Homo sapiens	152-157
30485073-4	2019	Novel PSMA inhibitors were prepared using lysine as the backbone to connect three different functional groups: the glutamate-urea-lysine (GUL) structure for inhibiting PSMA, 2-nitroimidazole for the hypoxia-sensitive moiety, and a near-infrared fluorophore (sulfo-Cyanine 5.5).	Lysine	42-48	folate hydrolase 1	Homo sapiens	6-10
30442713-2	2019	We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.	Lysine	194-197	lysine (K)-specific demethylase 1A	Mus musculus	154-158
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	197-200	NDC80 kinetochore complex component	Homo sapiens	150-154
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	208-211	NDC80 kinetochore complex component	Homo sapiens	150-154
30881663-0	2019	Lysine carbonylation is a previously unrecognized contributor to peroxidase activation of cytochrome c by chloramine-T.	Lysine	0-6	cytochrome c, somatic	Homo sapiens	90-102
30616689-1	2019	BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me).	Lysine	175-181	DOT1 like histone lysine methyltransferase	Homo sapiens	12-51
30616689-1	2019	BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me).	Lysine	175-181	DOT1 like histone lysine methyltransferase	Homo sapiens	53-58
30472188-4	2019	We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ.	Lysine	40-46	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	96-99
30361468-7	2019	We found that Ssh4-Rsp5 can target and ubiquitinate multiple lysines within a restricted distance from the membrane, providing a fail-safe mechanism for a diverse cargo repertoire.	Lysine	61-68	Ssh4p	Saccharomyces cerevisiae S288C	14-18
30409904-3	2019	Here, using Bcl6 -/- knockout mice, HEK293A and HCT116 p53 -/- cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage-induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1.	Lysine	175-178	tumor protein p53	Homo sapiens	135-138
30409904-3	2019	Here, using Bcl6 -/- knockout mice, HEK293A and HCT116 p53 -/- cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage-induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1.	Lysine	175-178	tumor protein p53	Homo sapiens	135-138
30409904-3	2019	Here, using Bcl6 -/- knockout mice, HEK293A and HCT116 p53 -/- cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage-induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1.	Lysine	175-178	tumor protein p53	Homo sapiens	135-138
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	C-X-C motif chemokine ligand 14	Homo sapiens	17-23
30994606-5	2019	The obtained results demonstrated direct cause-and-effect relationships between polymorphisms lys-198 asn in the END-1 gene, C60T, T58C in the SOD-2 gene and the function of vascular access.	Lysine	94-97	endothelin 1	Homo sapiens	113-118
30994606-6	2019	The presence of END-1 gene lys-198 asn polymorphism in a homozygous state (allele 1) was associated with a high risk of an unsatisfactory condition of permanent vascular access (p=0.019).	Lysine	27-30	endothelin 1	Homo sapiens	16-21
30315854-0	2019	Lysines residing in putative Small Ubiquitin-like MOdifier (SUMO) motifs regulate fate and function of 37 KDa laminin receptor.	Lysine	0-7	ribosomal protein SA	Homo sapiens	103-126
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
30040487-3	2019	In this study, we showed that RYBP inhibits the polyubiquitination-mediated proteasomal degradation of Ring1B independently of its ubiquitin (Ub)-protein isopeptide ligase (E3) ligase activity, leading to its stabilization and increased catalytic activity toward monoubiquitination of histone H2A at lysine 119.	Lysine	300-306	RING1 and YY1 binding protein	Homo sapiens	30-34
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	mitogen-activated protein kinase 1	Homo sapiens	225-228
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	mitogen-activated protein kinase 3	Homo sapiens	229-235
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	C-X-C motif chemokine ligand 9	Homo sapiens	287-292
30431069-2	2019	In this study, we propose a novel mechanism through which HOTAIR promotes EMT by switching histone H3 lysine 27 acetylation to methylation at the E-cadherin promoter, which induces the transcriptional inhibition of E-cadherin.	Lysine	102-108	cadherin 1	Homo sapiens	146-156
30431069-2	2019	In this study, we propose a novel mechanism through which HOTAIR promotes EMT by switching histone H3 lysine 27 acetylation to methylation at the E-cadherin promoter, which induces the transcriptional inhibition of E-cadherin.	Lysine	102-108	cadherin 1	Homo sapiens	215-225
30394687-5	2019	Here, we demonstrated that S100A10 was succinylated at lysine residue 47 (K47), and levels of succinylated S100A10 were increased in human GC.	Lysine	55-61	S100 calcium binding protein A10	Homo sapiens	27-34
30453113-4	2019	Here, we analysis the structural effects of 4-HNE modification through formation of Michael adducts of Cys-4HNE, His-4HNE and Lys-4HNE on Serum Albumin (BSA) and Thioredoxin (TRX).	Lysine	126-129	albumin	Homo sapiens	138-151
31087293-0	2019	Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo.	Lysine	28-34	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	50-53
31087303-3	2019	Much like nucleosomal histones, the tumor suppressor protein p53 is acetylated on a number of distinct lysine residues, often with distinct functional consequences.	Lysine	103-109	tumor protein p53	Homo sapiens	61-64
30733656-4	2019	The N399K substitution renders GDF6 more similar to noggin-resistant members of the BMP family, namely GDF2 and BMP10, both of which contain lysine in the corresponding position.	Lysine	141-147	bone morphogenetic protein 10	Homo sapiens	84-87
30733656-4	2019	The N399K substitution renders GDF6 more similar to noggin-resistant members of the BMP family, namely GDF2 and BMP10, both of which contain lysine in the corresponding position.	Lysine	141-147	growth differentiation factor 2	Homo sapiens	103-107
30733656-4	2019	The N399K substitution renders GDF6 more similar to noggin-resistant members of the BMP family, namely GDF2 and BMP10, both of which contain lysine in the corresponding position.	Lysine	141-147	bone morphogenetic protein 10	Homo sapiens	112-117
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	C-X-C motif chemokine ligand 9	Homo sapiens	248-285
30910030-6	2019	Each isopeptide bond is formed by transfer of an Ubc7-linked activated Ub to a lysine side chain of an acceptor Ub.	Lysine	79-85	E2 ubiquitin-conjugating protein UBC7	Saccharomyces cerevisiae S288C	49-53
29779173-7	2019	Gcdh-/- mice fed with 2.8% Lys diet also showed increased GRP78/BiP immunoreactivity in oligodendrocytes and neurons, denoting ER stress.	Lysine	27-30	heat shock protein 5	Mus musculus	58-63
29779173-7	2019	Gcdh-/- mice fed with 2.8% Lys diet also showed increased GRP78/BiP immunoreactivity in oligodendrocytes and neurons, denoting ER stress.	Lysine	27-30	heat shock protein 5	Mus musculus	64-67
30154425-4	2019	Here we report that the HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and in vivo.	Lysine	111-117	twist family bHLH transcription factor 1	Homo sapiens	168-174
30154425-4	2019	Here we report that the HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and in vivo.	Lysine	111-117	twist family bHLH transcription factor 1	Homo sapiens	227-233
30099980-2	2019	In the mouse zygote, dimethylated histone H3 lysine 9 (H3K9me2) attracts Dppa3 to prevent Tet3-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC).	Lysine	45-51	tet methylcytosine dioxygenase 3	Mus musculus	90-94
30525485-2	2018	The aim of this study was to examine the anti-inflammatory properties of a DAL-PEG-DK5 conjugate composed of a lysine-rich derivative of amphibian temporin-1CEb (DK5) and dalargin (DAL), the synthetic Leu-enkephalin analogue.	Lysine	111-117	Eph receptor B3	Mus musculus	83-86
30445810-4	2018	Here, we report structural analyses of a model system that comprised the lysine-rich cytochrome c and two PEGylated variants of sulfonatocalix[4]arene.	Lysine	73-79	cytochrome c, somatic	Homo sapiens	85-97
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	122-125	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-150
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	122-125	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-150
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	122-125	tumor necrosis factor	Homo sapiens	201-209
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	134-137	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-150
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	134-137	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-150
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	134-137	tumor necrosis factor	Homo sapiens	201-209
30525485-2	2018	The aim of this study was to examine the anti-inflammatory properties of a DAL-PEG-DK5 conjugate composed of a lysine-rich derivative of amphibian temporin-1CEb (DK5) and dalargin (DAL), the synthetic Leu-enkephalin analogue.	Lysine	111-117	Eph receptor B3	Mus musculus	162-165
30537988-10	2018	Furthermore, SAHA pretreatment compromised IFN-gamma-induced upregulation of histone H3 lysine 9 acetylation level in B7-H1 gene promoter.	Lysine	88-94	interferon gamma	Mus musculus	43-52
30537988-10	2018	Furthermore, SAHA pretreatment compromised IFN-gamma-induced upregulation of histone H3 lysine 9 acetylation level in B7-H1 gene promoter.	Lysine	88-94	CD274 antigen	Mus musculus	118-123
30146486-5	2018	Rather, FASNKD elevated malonyl-CoA levels, causing malonylation (a post-translational modification) of mTOR at lysine 1218 (K1218).	Lysine	112-118	mechanistic target of rapamycin kinase	Homo sapiens	104-108
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	148-151	XPA, DNA damage recognition and repair factor	Homo sapiens	141-144
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	ATR serine/threonine kinase	Homo sapiens	0-3
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	XPA, DNA damage recognition and repair factor	Homo sapiens	32-35
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	XPA, DNA damage recognition and repair factor	Homo sapiens	141-144
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	ATR serine/threonine kinase	Homo sapiens	0-3
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	XPA, DNA damage recognition and repair factor	Homo sapiens	32-35
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	XPA, DNA damage recognition and repair factor	Homo sapiens	141-144
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	98-101	ATR serine/threonine kinase	Homo sapiens	18-21
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	98-101	XPA, DNA damage recognition and repair factor	Homo sapiens	31-34
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	98-101	XPA, DNA damage recognition and repair factor	Homo sapiens	91-94
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	106-109	ATR serine/threonine kinase	Homo sapiens	18-21
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	106-109	XPA, DNA damage recognition and repair factor	Homo sapiens	31-34
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	106-109	ATR serine/threonine kinase	Homo sapiens	18-21
30327428-7	2018	Interference with ATR-mediated XPA phosphorylation at Ser-196 by persistent acetylation of XPA at Lys-63, Lys-67, and Lys-215 delays repair of UV-induced DNA damage and attenuates cAMP-enhanced NER.	Lysine	106-109	XPA, DNA damage recognition and repair factor	Homo sapiens	31-34
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	151-154	ATR serine/threonine kinase	Homo sapiens	34-37
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	151-154	XPA, DNA damage recognition and repair factor	Homo sapiens	44-47
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	159-162	ATR serine/threonine kinase	Homo sapiens	34-37
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	159-162	XPA, DNA damage recognition and repair factor	Homo sapiens	44-47
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	159-162	ATR serine/threonine kinase	Homo sapiens	34-37
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	159-162	XPA, DNA damage recognition and repair factor	Homo sapiens	44-47
30517868-1	2018	Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at target promoters for gene silencing.	Lysine	120-126	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	21-25
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	35-38	XPA, DNA damage recognition and repair factor	Homo sapiens	19-22
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	43-46	XPA, DNA damage recognition and repair factor	Homo sapiens	19-22
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	43-46	XPA, DNA damage recognition and repair factor	Homo sapiens	19-22
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	55-58	XPA, DNA damage recognition and repair factor	Homo sapiens	7-10
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	55-58	ATR serine/threonine kinase	Homo sapiens	112-115
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	55-58	XPA, DNA damage recognition and repair factor	Homo sapiens	116-119
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	XPA, DNA damage recognition and repair factor	Homo sapiens	7-10
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	ATR serine/threonine kinase	Homo sapiens	112-115
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	XPA, DNA damage recognition and repair factor	Homo sapiens	116-119
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	XPA, DNA damage recognition and repair factor	Homo sapiens	7-10
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	ATR serine/threonine kinase	Homo sapiens	112-115
30327428-5	2018	Mutant XPA containing acetylation mimetics at residues Lys-63, Lys-67, and Lys-215 exhibit blunted UV-dependent ATR-XPA interactions even in the presence of cAMP signals.	Lysine	63-66	XPA, DNA damage recognition and repair factor	Homo sapiens	116-119
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	148-151	ATR serine/threonine kinase	Homo sapiens	0-3
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	148-151	XPA, DNA damage recognition and repair factor	Homo sapiens	32-35
30446626-6	2018	In addition, binding of SETDB1 is observed at the flanking regions of Dppa2, Otx2 and Utf1 in cell aggregates containing PGCLCs, and trimethylation of lysine 9 of histone H3 is reduced by Setdb1 knockdown at those regions.	Lysine	151-157	SET domain, bifurcated 1	Mus musculus	24-30
30446626-6	2018	In addition, binding of SETDB1 is observed at the flanking regions of Dppa2, Otx2 and Utf1 in cell aggregates containing PGCLCs, and trimethylation of lysine 9 of histone H3 is reduced by Setdb1 knockdown at those regions.	Lysine	151-157	SET domain, bifurcated 1	Mus musculus	188-194
30318657-4	2018	The results showed that the duodenal supply of Glu, Gln, Lys, Thr, and Val enhanced ghrelin release.	Lysine	57-60	appetite-regulating hormone	Ovis aries	84-91
30259240-4	2018	Apo B100 contains 33 analogues of Cardin-Weintraub arginine/lysine-based receptor ligand motifs and shares key lysine motifs and sequence similarity with the LDL receptor-associated protein, MESD, and heat shock proteins.	Lysine	60-66	apolipoprotein B	Homo sapiens	0-8
30250978-10	2018	Engineering mSA to introduce additional lysine residues can increase the reporter signal above that of wild-type streptavidin.	Lysine	40-46	exonuclease 1	Mus musculus	12-15
30251657-3	2018	THB1, which is cytoplasmic and capable of nitric oxide dioxygenation activity, uses a histidine and a lysine as axial ligands to the heme iron.	Lysine	102-108	uncharacterized protein	Chlamydomonas reinhardtii	0-4
30338896-1	2018	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its trimethylated form (H3K27me), inducing by this way block of transcription and gene silencing.	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
30338896-1	2018	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its trimethylated form (H3K27me), inducing by this way block of transcription and gene silencing.	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
26876003-4	2018	Chimeric-tPA was purified by lysine-sepharose chromatography and specific aptamers were designed using SELEX method.	Lysine	29-35	plasminogen activator, tissue type	Homo sapiens	9-12
30479053-5	2018	In the molecular modeling study, compound 4e (docking score = -8.70) showed important hydrogen bond interaction with the amino acids LYS 329, SER 137, GLY 136 and pi-pi interactions with PHE 189 at the active site of GABA-AT.	Lysine	133-136	4-aminobutyrate aminotransferase	Homo sapiens	217-224
30272279-3	2018	Bromodomain-containing protein 4 (BRD4) is an epigenetic reader protein that binds to acetylated lysine on histones and has been reported to serve critical roles in numerous types of cancers.	Lysine	97-103	bromodomain containing 4	Homo sapiens	0-32
30272279-3	2018	Bromodomain-containing protein 4 (BRD4) is an epigenetic reader protein that binds to acetylated lysine on histones and has been reported to serve critical roles in numerous types of cancers.	Lysine	97-103	bromodomain containing 4	Homo sapiens	34-38
30043476-5	2018	The ewes that received dietary supplementation with rumen-protected lysine alone (C) had significantly lower CCL-5 transcript levels in their macrophages than the ewes fed the other supplemented diets.	Lysine	68-74	C-C motif chemokine 5	Ovis aries	109-114
30404815-7	2018	Besides, the KLF4 binding regions on IL-23 or IL-36a promoters and the KLF4 lysine site acetylated by PCAF were identified.	Lysine	76-82	Kruppel like factor 4	Rattus norvegicus	71-75
30089852-4	2018	Here we show that the histone-lysine N-methyltransferase MLL1/WDR5 complexes physically interact with SOX2 and evoke SOX2 proteolysis, possibly through methylation on a potential site lysine 42 (K42).	Lysine	30-36	WD repeat domain 5	Homo sapiens	62-66
29633022-6	2018	Moreover, mutant IDH1 can drive the immortalization and transformation of p53-/pRb-deficient astrocytes by reactivating telomerase and stabilizing telomeres in combination with increased histone lysine methylation and c-Myc/Max binding at the TERT promoter.	Lysine	195-201	tumor protein p53	Homo sapiens	74-77
30498193-6	2018	MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	146-152	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	111-116
30203048-1	2018	The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome.	Lysine	83-89	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	30-34
30488017-0	2018	The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer.	Lysine	15-21	WD repeat domain 5	Homo sapiens	34-38
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	protein arginine methyltransferase 5	Homo sapiens	133-138
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	protein arginine methyltransferase 5	Homo sapiens	133-138
30487153-2	2018	We found that de novo EBV infection of primary B cells caused moderate induction of enhancer of zeste homolog 2 (EZH2), the major histone H3 lysine 27 (K27) methyltransferase.	Lysine	141-147	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	113-117
30510924-5	2018	In particular, enhancer of zeste homolog 2 (EZH2), the catalytic core subunit of PRC2, acts as an epigenetic silencer of many tumor suppressor genes through the trimethylation of lysine 27 on histone H3, an essential binding site for DNA methyl transferases and histone deacetylases.	Lysine	179-185	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	15-42
30510924-5	2018	In particular, enhancer of zeste homolog 2 (EZH2), the catalytic core subunit of PRC2, acts as an epigenetic silencer of many tumor suppressor genes through the trimethylation of lysine 27 on histone H3, an essential binding site for DNA methyl transferases and histone deacetylases.	Lysine	179-185	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	44-48
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	117-120	protein arginine methyltransferase 5	Homo sapiens	178-183
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	127-130	protein arginine methyltransferase 5	Homo sapiens	178-183
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	WD repeat domain 5	Homo sapiens	41-45
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	148-153
30257864-3	2018	In this study, using MS analyses, we found that PRMT5 itself is methylated in human erythroleukemia Lys-562 cells.	Lysine	100-103	protein arginine methyltransferase 5	Homo sapiens	48-53
30427907-5	2018	Furthermore, hnRNPA2, a mitochondrial stress responsive lysine acetyltransferase (KAT) acetylates telomere histone H4at lysine 8 of (H4K8) and this acetylation is associated with telomere attrition.	Lysine	56-62	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	13-20
30422989-2	2018	Here, we report that the H3 lysine 36 trimethylation (H3K36me3), catalyzed by histone methyltransferase SET-domain-containing 2 (SETD2), regulates lineage commitment of BMSCs.	Lysine	28-34	SET domain containing 2	Mus musculus	104-127
30422989-2	2018	Here, we report that the H3 lysine 36 trimethylation (H3K36me3), catalyzed by histone methyltransferase SET-domain-containing 2 (SETD2), regulates lineage commitment of BMSCs.	Lysine	28-34	SET domain containing 2	Mus musculus	129-134
30399166-0	2018	Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.	Lysine	44-47	superoxide dismutase 1	Homo sapiens	60-82
30408026-7	2018	TRIM59 stabilized PDCD10 by suppressing RING finger and transmembrane domain-containing protein 1 (RNFT1)-induced lysine 63 (K63) ubiquitination and subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation.	Lysine	114-120	tripartite motif containing 59	Homo sapiens	0-6
30405132-3	2018	Here we show that NOD2 signaling involves conjugation of RIP2 with lysine 63 (K63), K48 and M1 polyubiquitin chains, as well as with non-canonical K27 chains.	Lysine	67-73	receptor (TNFRSF)-interacting serine-threonine kinase 2	Mus musculus	57-61
30399166-7	2018	Here, we examined whether loss of positively charged surface Lys residues in SOD1 would induce misfolding and formation of intracellular inclusions.	Lysine	61-64	superoxide dismutase 1	Homo sapiens	77-81
30399166-11	2018	Our findings may have implications for the low frequency of mutations at Lys residues SOD1 in ALS patients.	Lysine	73-76	superoxide dismutase 1	Homo sapiens	86-90
30228180-7	2018	Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5).	Lysine	104-107	WD repeat domain 5	Homo sapiens	176-180
30224386-6	2018	Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover.	Lysine	70-73	ubiquitin specific peptidase 38	Mus musculus	17-22
30110572-16	2018	The increased levels of Sp3 lysine acetylation decreased in DETC rats with tempol.	Lysine	28-34	Sp3 transcription factor	Rattus norvegicus	24-27
30110572-17	2018	Taken together, our results suggest that superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and BP in rats.	Lysine	76-82	Sp3 transcription factor	Rattus norvegicus	68-71
30278358-5	2018	Post-translationally modified YB-1 (lysine 301/304 acetylation) is detected at high levels in the nucleus of adherent and invading CD14+CD68+ monocytes from umbilical cord and atherosclerosis-prone vessels.	Lysine	36-42	Y-box binding protein 1	Homo sapiens	30-34
30596070-3	2018	Moreover, H3 lysine 27 trimethylation (H3K27me3) is catalyzed by enhancer of zeste homolog 2 (EZH2) and plays a critical role in SCLC chemoresistance.	Lysine	13-19	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-92
30596070-3	2018	Moreover, H3 lysine 27 trimethylation (H3K27me3) is catalyzed by enhancer of zeste homolog 2 (EZH2) and plays a critical role in SCLC chemoresistance.	Lysine	13-19	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	94-98
30282605-7	2018	Dynamic replacement of the native sixth coordination bond of methionine-80 by lysines (72, 73, and 79) and partially also by histidines (26 and 33) provides an efficient way how to increase peroxidase-like activity of cyt c without significant conformational change at physiological conditions.	Lysine	78-85	cytochrome c, somatic	Homo sapiens	218-223
30031905-8	2018	Furthermore, when Gata4 is knocked down, the chromatin at the RANKL region is further opened, as detected by a reduction in histone 3 lysine 27 trimethylation (H3K27me3) and an increase in histone 3 lysine 4 dimethylation (H3K4me2) in the RANKL locus.	Lysine	134-140	GATA binding protein 4	Mus musculus	18-23
30031905-8	2018	Furthermore, when Gata4 is knocked down, the chromatin at the RANKL region is further opened, as detected by a reduction in histone 3 lysine 27 trimethylation (H3K27me3) and an increase in histone 3 lysine 4 dimethylation (H3K4me2) in the RANKL locus.	Lysine	199-205	GATA binding protein 4	Mus musculus	18-23
30401430-4	2018	At the cell surface, PrPC Lys residues interact with Abetao to create a hydrogel containing immobile Abetao and relatively mobile PrPC.	Lysine	26-29	prion protein	Homo sapiens	21-25
29943387-8	2018	CONCLUSIONS: FFA levels are elevated in newly diagnosed and long-term controlled T2DM patients, providing high diagnostic accuracy of 87% and 91%, respectively, which improved further when combined with the glycation degree of lysine-141 in haptoglobin.	Lysine	227-233	haptoglobin	Homo sapiens	241-252
30172749-9	2018	Mechanistically, HOTAIR inhibited p15 expression through zeste homolog 2 (EZH2)-enrolled tri-methylation of Lys 27 of histone H3 (H3K27me3) in p15 promoter.	Lysine	108-111	HOX transcript antisense RNA (non-protein coding)	Mus musculus	17-23
30172749-9	2018	Mechanistically, HOTAIR inhibited p15 expression through zeste homolog 2 (EZH2)-enrolled tri-methylation of Lys 27 of histone H3 (H3K27me3) in p15 promoter.	Lysine	108-111	cyclin dependent kinase inhibitor 2B	Mus musculus	34-37
30172749-9	2018	Mechanistically, HOTAIR inhibited p15 expression through zeste homolog 2 (EZH2)-enrolled tri-methylation of Lys 27 of histone H3 (H3K27me3) in p15 promoter.	Lysine	108-111	cyclin dependent kinase inhibitor 2B	Mus musculus	143-146
30232138-8	2018	PB lacking LSD1 displayed increased histone H3 lysine 4 monomethylation and chromatin accessibility at nB active enhancers and the binding sites of transcription factors Blimp-1, PU.1, and IRF4 that mapped to LSD1-repressed genes.	Lysine	47-53	lysine (K)-specific demethylase 1A	Mus musculus	11-15
30220105-5	2018	The reversible LSD1 inhibitor HCI-2509 significantly reduced cell growth with an IC50 of 0.3-5 mumin vitro, which was linked to an enhancement of histone 3 lysine methylation.	Lysine	156-162	lysine (K)-specific demethylase 1A	Mus musculus	15-19
30401430-4	2018	At the cell surface, PrPC Lys residues interact with Abetao to create a hydrogel containing immobile Abetao and relatively mobile PrPC.	Lysine	26-29	prion protein	Homo sapiens	130-134
30359362-4	2018	CTCF-dependent looping is dependent on the expression of the CTCF-associated Yin Yang 1 (YY1) transcription factor and polycomb repressor complex (PRC) recruitment, resulting in trimethylation of histone H3 at lysine 27.	Lysine	210-216	YY1 transcription factor	Homo sapiens	77-87
30226578-0	2018	Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.	Lysine	0-7	WD repeat domain 5	Homo sapiens	35-39
30226578-0	2018	Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.	Lysine	0-7	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	53-58
30226578-4	2018	In the present study, it was reported that lysines 207 and 325 (K207 and K325, respectively) of WDR5 were monomethylated by SET-domain-containing protein methyltransferase 6.	Lysine	43-50	WD repeat domain 5	Homo sapiens	96-100
30226578-6	2018	Methylation of K207/K325 on WDR5 partially contributed to maintaining global histone tri-methylation of lysine 4 on histone H3 levels, but did not affect MLL/SET1 complex assembly.	Lysine	104-110	WD repeat domain 5	Homo sapiens	28-32
30253095-5	2018	Selectivity for the BRD4 N-terminal bromodomain (BRD4(1)) over its second bromodomain (BRD4(2)) arises from the displacement of ordered waters and the conformational flexibility of lysine-141 in BRD4(1).	Lysine	181-187	bromodomain containing 4	Homo sapiens	20-24
30226578-7	2018	These results further understanding of a potential post-translational modification of WDR5, and imply that the methylation of lysines on HMT complex components is crucial for regulating human carcinogenesis.	Lysine	126-133	WD repeat domain 5	Homo sapiens	86-90
30359362-4	2018	CTCF-dependent looping is dependent on the expression of the CTCF-associated Yin Yang 1 (YY1) transcription factor and polycomb repressor complex (PRC) recruitment, resulting in trimethylation of histone H3 at lysine 27.	Lysine	210-216	YY1 transcription factor	Homo sapiens	89-92
30253095-5	2018	Selectivity for the BRD4 N-terminal bromodomain (BRD4(1)) over its second bromodomain (BRD4(2)) arises from the displacement of ordered waters and the conformational flexibility of lysine-141 in BRD4(1).	Lysine	181-187	bromodomain containing 4	Homo sapiens	49-53
30190324-8	2018	In a reconstituted system in bacteria, I analyzed HSP90/P23-associated, SMYD2-mediated ERalpha methylation and found that when SMYD2 binds to the molecular chaperones, it considerably increases methylation of Lys-266 in ERalpha.	Lysine	209-212	estrogen receptor 1	Homo sapiens	87-94
30253095-5	2018	Selectivity for the BRD4 N-terminal bromodomain (BRD4(1)) over its second bromodomain (BRD4(2)) arises from the displacement of ordered waters and the conformational flexibility of lysine-141 in BRD4(1).	Lysine	181-187	bromodomain containing 4	Homo sapiens	49-53
30253095-5	2018	Selectivity for the BRD4 N-terminal bromodomain (BRD4(1)) over its second bromodomain (BRD4(2)) arises from the displacement of ordered waters and the conformational flexibility of lysine-141 in BRD4(1).	Lysine	181-187	bromodomain containing 4	Homo sapiens	49-53
30189201-0	2018	Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6.	Lysine	50-56	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	75-80
30190324-8	2018	In a reconstituted system in bacteria, I analyzed HSP90/P23-associated, SMYD2-mediated ERalpha methylation and found that when SMYD2 binds to the molecular chaperones, it considerably increases methylation of Lys-266 in ERalpha.	Lysine	209-212	estrogen receptor 1	Homo sapiens	220-227
30323246-7	2018	The mechanistic study revealed that inflammatory cytokines (IL-6, TNF-alpha) are transcriptionally activated by an acetylated lysine residue in histone (H3K27ac) of chromatin by binding to its promoter and subsequently regulating gene expression.	Lysine	126-132	interleukin 6	Mus musculus	60-64
30120199-3	2018	A pathognomonic TDP-43 C-terminal fragment (CTF) spanning amino acids 193-414 contains only four lysine residues that could be potentially ubiquitinylated.	Lysine	97-103	TAR DNA binding protein	Homo sapiens	16-22
30323246-7	2018	The mechanistic study revealed that inflammatory cytokines (IL-6, TNF-alpha) are transcriptionally activated by an acetylated lysine residue in histone (H3K27ac) of chromatin by binding to its promoter and subsequently regulating gene expression.	Lysine	126-132	tumor necrosis factor	Mus musculus	66-75
30120199-7	2018	Thus, Lys-408 ubiquitinylation appears to hinder Ser-409/410 phosphorylation in TDP-43 CTF.	Lysine	6-9	TAR DNA binding protein	Homo sapiens	80-86
30120199-9	2018	We extended the mutagenesis study to full-length TDP-43 and performed MS. Ubiquitinylated lysine residues were identified in the nuclear localization sequence (NLS; Lys-84 and Lys-95) and RNA-binding region (mostly Lys-160, Lys-181, and Lys-263).	Lysine	90-96	TAR DNA binding protein	Homo sapiens	49-55
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	92-95	TAR DNA binding protein	Homo sapiens	30-36
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	92-95	TAR DNA binding protein	Homo sapiens	139-145
30304683-6	2018	Although Tnks-dependent poly-ADP-ribosylation is tightly coupled to proteolysis in the proteasome, we demonstrate that Tnks initiates degradation-independent ubiquitination on two lysine residues of JNK to promote its kinase activity and in vivo functions.	Lysine	180-186	tankyrase	Drosophila melanogaster	119-123
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	92-95	TAR DNA binding protein	Homo sapiens	139-145
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	103-106	TAR DNA binding protein	Homo sapiens	30-36
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	103-106	TAR DNA binding protein	Homo sapiens	139-145
30120199-12	2018	Collectively, our analysis of TDP-43 ubiquitinylation sites indicates that the NLS residues Lys-84 and Lys-95 have more prominent roles in TDP-43 function than the more C-terminal lysines and suggests a link between specific ubiquitinylation events and pathological TDP-43 phosphorylation.	Lysine	103-106	TAR DNA binding protein	Homo sapiens	139-145
30525090-1	2018	We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation.	Lysine	43-49	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	76-82
30525090-1	2018	We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation.	Lysine	43-49	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	84-108
28479601-4	2018	More than a decade ago, we reported that replacement of a murine B7-DC mutant lysine with serine (K113S) at positive 113 resulted in a loss of binding capacity to PD-1.	Lysine	78-84	programmed cell death 1 ligand 2	Mus musculus	65-70
30135206-5	2018	The mechanism consists of an IFN-induced, Bcl3- and p300-dependent PD-L1 promoter occupancy by Lys-314/315 acetylated p65 NF-kappaB.	Lysine	95-98	interferon gamma	Homo sapiens	29-32
29800064-2	2018	Acetylation/de-acetylation of specific lysine residues in Smad2/3 has been shown to regulate TGF-beta signalling by altering its transcriptional activity.	Lysine	39-45	SMAD family member 2	Mus musculus	58-65
30286792-9	2018	CONCLUSIONS: Our findings provide new insights into the roles of lysine methylation in non-histone substrates which are targeted by the G9a/GLP complex and suggest a potential function of ATF7IP methylation in SETDB1/MPP8-mediated transgene silencing.	Lysine	65-71	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	210-216
29650545-12	2018	CONCLUSIONS: We have defined molecularly that Gal-1 promotes CaV1.2 degradation by replacing CaVbeta and thereby exposing specific lysines for polyubiquitination and by masking I-II loop endoplasmic reticulum export signals.	Lysine	131-138	galectin 1	Rattus norvegicus	46-51
29650545-12	2018	CONCLUSIONS: We have defined molecularly that Gal-1 promotes CaV1.2 degradation by replacing CaVbeta and thereby exposing specific lysines for polyubiquitination and by masking I-II loop endoplasmic reticulum export signals.	Lysine	131-138	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	61-67
28479601-4	2018	More than a decade ago, we reported that replacement of a murine B7-DC mutant lysine with serine (K113S) at positive 113 resulted in a loss of binding capacity to PD-1.	Lysine	78-84	programmed cell death 1	Mus musculus	163-167
30112706-1	2018	PURPOSE OF REVIEW: Enhancer of Zeste Homolog 2 (EZH2) is histone methyltransferase and catalyzes the methylation of histone 3 lysine 27, a mark of transcriptional repression.	Lysine	126-132	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	19-46
30112706-1	2018	PURPOSE OF REVIEW: Enhancer of Zeste Homolog 2 (EZH2) is histone methyltransferase and catalyzes the methylation of histone 3 lysine 27, a mark of transcriptional repression.	Lysine	126-132	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	48-52
30150325-5	2018	This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering.	Lysine	37-43	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	74-91
30150325-5	2018	This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering.	Lysine	37-43	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	93-96
30237125-3	2018	However, several studies have demonstrated that the monomeric NAA10 can acetylate the internal lysine residues of several substrates including hypoxia-inducible factor 1alpha (HIF-1alpha).	Lysine	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-174
29624717-7	2018	A mechanistic study found that nuclear SIRT3 was recruited to the HBV cccDNA, where it deacetylated histone 3 lysine 9.	Lysine	110-116	sirtuin 3	Homo sapiens	39-44
29921733-6	2018	Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis revealed that aromatase is basally acetylated on several lysine residues (108, 169, 242, 262, 334, 352, and 354) in MCF-7 cells, and treatment with a SIRT-1 inhibitor induced additional acetylation (376, 390, 440, and 448).	Lysine	124-130	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-90
29921733-7	2018	These acetylated lysine residues are in regions critical for aromatase activity.	Lysine	17-23	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	61-70
30142602-10	2018	Interestingly, mass spectrometry sequencing of SOD1 aggregates revealed preferential secosterol adduction to Lys residues located at the electrostatic loop (Lys 122, 128 and 136) and nearby the dimer interface (Lys 3 and 9).	Lysine	109-112	superoxide dismutase 1	Rattus norvegicus	47-51
30142602-10	2018	Interestingly, mass spectrometry sequencing of SOD1 aggregates revealed preferential secosterol adduction to Lys residues located at the electrostatic loop (Lys 122, 128 and 136) and nearby the dimer interface (Lys 3 and 9).	Lysine	157-160	superoxide dismutase 1	Rattus norvegicus	47-51
30066891-3	2018	Enhancer of zeste homolog 2 (EZH2) is the core enzymatic subunit of polycomb repressor complex 2 and is responsible for the trimethylation of histone 3 on lysine 27 (H3K27me3); it is also able to silence a bundle of tumor suppressor genes through promoter binding.	Lysine	155-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
30066891-3	2018	Enhancer of zeste homolog 2 (EZH2) is the core enzymatic subunit of polycomb repressor complex 2 and is responsible for the trimethylation of histone 3 on lysine 27 (H3K27me3); it is also able to silence a bundle of tumor suppressor genes through promoter binding.	Lysine	155-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
30035374-3	2018	In this pathway, the aminotransferase AGD2-like defense response protein (ALD1) alpha-transaminates l-lysine and generates cyclic dehydropipecolic (DP) intermediates that are subsequently reduced to pipecolic acid (Pip) by the reductase SAR-deficient 4 (SARD4).	Lysine	100-108	ARF-GAP domain 2	Arabidopsis thaliana	38-42
30237125-3	2018	However, several studies have demonstrated that the monomeric NAA10 can acetylate the internal lysine residues of several substrates including hypoxia-inducible factor 1alpha (HIF-1alpha).	Lysine	95-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-186
30304920-9	2018	EZH2 suppressed the expression of miR-139-5p through up-regulating Histone 3 Lysine 27 Trimethylation (H3K27me3).	Lysine	77-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	148-154	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	40-43
30310315-8	2018	KMT2C gene mutations were mainly detected in HER2+ samples (7/10), which were correlated with the lysine degradation pathway.	Lysine	98-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	148-154	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	164-167
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	148-154	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	164-167
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	156-159	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	40-43
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	156-159	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	164-167
30148623-2	2018	The main component of natural bee venom MLT was modified by introducing a pH-sensitive amide bond between the 2,3-dimethyl maleimide (DMMA) and the lysine (Lys) of MLT (MLT-DMMA).	Lysine	156-159	mitogen-activated protein kinase kinase kinase 20	Homo sapiens	164-167
30510991-8	2019	The C232 mutant showed impaired repression of IL2 and diminished EZH2-mediated trimethylation of histone 3 at lysine 27 on interferon gamma, indicative of compromised Treg physiologic function.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
30111536-2	2018	SUV39H1/2-mediated histone H3 lysine-9 trimethylation (H3K9me3) is a major barrier to efficient reprogramming.	Lysine	30-36	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
29969683-5	2018	In the presence of BR, the transcription factor BRASSINAZOLE-RESISTANT1 (BZR1), together with BES1-INTERACTING MYC-like proteins (BIMs), specifically binds a BR- responsive element in the first intron of FLC and further recruits a histone 3 lysine 27 (H3K27) demethylase to downregulate levels of the repressive H3K27 trimethylation mark and thus antagonize Polycomb silencing at FLC, leading to its activation.	Lysine	241-247	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	204-207
30263097-0	2018	STAT3 is constitutively acetylated on lysine 685 residues in chronic lymphocytic leukemia cells.	Lysine	38-44	signal transducer and activator of transcription 3	Homo sapiens	0-5
30263097-4	2018	Using Western immunoblotting, immunoprecipitation, and flow cytometry we found that, apart from its constitutive serine phosphorylation, STAT3 is constitutively acetylated on lysine 685 residues.	Lysine	175-181	signal transducer and activator of transcription 3	Homo sapiens	137-142
30263097-5	2018	Because the acetyltransferase p300 was found to acetylate STAT3 on lysine 685 residues, we wondered whether p300 acetylates STAT3 in CLL cells.	Lysine	67-73	signal transducer and activator of transcription 3	Homo sapiens	58-63
30206209-9	2018	The forced expression of ubiquitin and p11 in 293 T cells resulted in ubiquitylation of p11 that was blocked by mutagenesis of lysine 57.	Lysine	127-133	S100 calcium binding protein A10	Homo sapiens	39-42
30206209-9	2018	The forced expression of ubiquitin and p11 in 293 T cells resulted in ubiquitylation of p11 that was blocked by mutagenesis of lysine 57.	Lysine	127-133	S100 calcium binding protein A10	Homo sapiens	88-91
30103943-4	2018	In this study, we found that the expression of EZH2 and H3K27me3 (trimethylation on lysine 27 in histone H3) decreased during osteogenesis of human dental follicle stem cells (hDFSCs).	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	47-51
30214048-6	2018	The JMJD2B-dependent upregulation of PPARgamma2 was associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2.	Lysine	120-126	lysine demethylase 4B	Homo sapiens	4-10
30214048-6	2018	The JMJD2B-dependent upregulation of PPARgamma2 was associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2.	Lysine	120-126	peroxisome proliferator activated receptor gamma	Homo sapiens	37-47
30214048-6	2018	The JMJD2B-dependent upregulation of PPARgamma2 was associated with the removal of di- and trimethylation of histone H3 lysine 9 on the promoter of PPARgamma2.	Lysine	120-126	peroxisome proliferator activated receptor gamma	Homo sapiens	148-158
29969683-5	2018	In the presence of BR, the transcription factor BRASSINAZOLE-RESISTANT1 (BZR1), together with BES1-INTERACTING MYC-like proteins (BIMs), specifically binds a BR- responsive element in the first intron of FLC and further recruits a histone 3 lysine 27 (H3K27) demethylase to downregulate levels of the repressive H3K27 trimethylation mark and thus antagonize Polycomb silencing at FLC, leading to its activation.	Lysine	241-247	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	380-383
30041976-2	2018	PRC2 represses gene transcription through tri-methylation of lysine 27 of histone 3 (H3K27me3) by its catalytic subunit EZH2.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	120-124
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	Lysine	199-205	interleukin 6	Homo sapiens	80-93
29902553-7	2018	However, RES-alpha-dicarbonyl conjugates oxidized Cys34 and lysine, arginine and/or proline by a nucleophilic attack on SH and epsilon-NH groups in HSA.	Lysine	60-66	albumin	Homo sapiens	148-151
30194494-2	2018	Lysozyme-conjugated Fe3O4 nanoparticles (Lys-Fe3O4NPs) were used to capture alpha-LA on the surface of the SPCEs which then is trapped in an immunosandwich using secondary antibodies labeled with ferrocene-modified gold nanoparticles.	Lysine	0-3	lactalbumin alpha	Homo sapiens	76-84
30150059-3	2018	Enhancer of zeste homolog 2 (EZH2), an oncogene responsible for the tri-methylation of histone H3 at lysine 27 (H3K27me3), was identified to be overexpressed in approximate 70-90% of HCC cases, which prompted us to investigate whether or how AR regulates EZH2 expression.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
30150059-3	2018	Enhancer of zeste homolog 2 (EZH2), an oncogene responsible for the tri-methylation of histone H3 at lysine 27 (H3K27me3), was identified to be overexpressed in approximate 70-90% of HCC cases, which prompted us to investigate whether or how AR regulates EZH2 expression.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
30186460-5	2018	hNIS-EGFP-hUCMSCs were labeled with SPIO under the mediation of poly-L-lysine, and SPIO, hNIS and EGFP co-labeled hUCMSCs were established successfully.	Lysine	64-77	solute carrier family 5 member 5	Homo sapiens	0-4
30761216-2	2018	PRC2 through EZH2 tri-methylates histone H3 lysine tail residue 27 (H3K27me3), a modification associated with repression of gene expression programs related to stem cell self-renewal, cell cycle, cell differentiation, and cellular transformation.	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
30092227-11	2018	We generated mutant apoA-I (K107E, M-apoA-I) with a substitution of glutamic acid (Glu, E) for lysine at the 107th site, and found that compared to wild type apoA-I (WT-apoA-I), M-apoA-I decreased its anti-inflammatory effects in THP-1 cells.	Lysine	95-101	apolipoprotein A1	Homo sapiens	20-26
29574790-3	2018	Through its catalytic activity, responsible for the tri-methylation of lysine 27 of the histone H3 (H3K27me3), EZH2 is a good target for both diagnosis and therapy of different pathologies.	Lysine	71-77	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	111-115
30092227-11	2018	We generated mutant apoA-I (K107E, M-apoA-I) with a substitution of glutamic acid (Glu, E) for lysine at the 107th site, and found that compared to wild type apoA-I (WT-apoA-I), M-apoA-I decreased its anti-inflammatory effects in THP-1 cells.	Lysine	95-101	apolipoprotein A1	Homo sapiens	37-43
30092227-0	2018	Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus.	Lysine	0-6	apolipoprotein A1	Homo sapiens	20-38
30092227-7	2018	We identified seven specific lysine (Lys, K) residues of apoA-I (K12, K23, K40, K96, K106, K107 and K238) that were susceptible to be glycated either in vitro or in vivo.	Lysine	29-35	apolipoprotein A1	Homo sapiens	57-63
30092227-11	2018	We generated mutant apoA-I (K107E, M-apoA-I) with a substitution of glutamic acid (Glu, E) for lysine at the 107th site, and found that compared to wild type apoA-I (WT-apoA-I), M-apoA-I decreased its anti-inflammatory effects in THP-1 cells.	Lysine	95-101	apolipoprotein A1	Homo sapiens	37-43
30092227-7	2018	We identified seven specific lysine (Lys, K) residues of apoA-I (K12, K23, K40, K96, K106, K107 and K238) that were susceptible to be glycated either in vitro or in vivo.	Lysine	37-40	apolipoprotein A1	Homo sapiens	57-63
30092227-11	2018	We generated mutant apoA-I (K107E, M-apoA-I) with a substitution of glutamic acid (Glu, E) for lysine at the 107th site, and found that compared to wild type apoA-I (WT-apoA-I), M-apoA-I decreased its anti-inflammatory effects in THP-1 cells.	Lysine	95-101	apolipoprotein A1	Homo sapiens	37-43
30092227-11	2018	We generated mutant apoA-I (K107E, M-apoA-I) with a substitution of glutamic acid (Glu, E) for lysine at the 107th site, and found that compared to wild type apoA-I (WT-apoA-I), M-apoA-I decreased its anti-inflammatory effects in THP-1 cells.	Lysine	95-101	apolipoprotein A1	Homo sapiens	37-43
29902490-8	2018	Furthermore, the histone 3 lysine 9 acetylation (H3K9ac) level in the StAR promoter was decreased by PDE from GD20 to PW12.	Lysine	27-33	steroidogenic acute regulatory protein	Rattus norvegicus	70-74
30150770-4	2018	Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS.	Lysine	84-90	superoxide dismutase 1, soluble	Mus musculus	198-202
30200334-0	2018	The Energetic Viability of Delta1-Piperideine Dimerization in Lysine-derived Alkaloid Biosynthesis.	Lysine	62-68	delta like non-canonical Notch ligand 1	Homo sapiens	27-33
30200334-4	2018	The involvement of the Delta 1 -piperideine dimerization has been proposed for some of the Lys-derived alkaloid biosyntheses, but no enzymes for this dimerization reaction have been reported to date; moreover, it is not clear whether this dimerization reaction proceeds spontaneously or enzymatically.	Lysine	91-94	delta like non-canonical Notch ligand 1	Homo sapiens	23-30
30150770-4	2018	Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS.	Lysine	146-152	superoxide dismutase 1, soluble	Mus musculus	198-202
30089272-5	2018	Mechanistically, PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca2+ overload.	Lysine	84-90	solute carrier family 8 member A1	Homo sapiens	140-144
29954944-4	2018	We further reveal that mutant p53 forms physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFalpha-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation.	Lysine	208-214	tumor protein p53	Homo sapiens	30-33
29954944-4	2018	We further reveal that mutant p53 forms physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFalpha-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation.	Lysine	208-214	tumor necrosis factor	Homo sapiens	166-174
29954944-4	2018	We further reveal that mutant p53 forms physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFalpha-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation.	Lysine	208-214	tumor protein p53	Homo sapiens	305-308
30143652-4	2018	Here, we present the first evidence for HNF-1A being a substrate of SUMOylation in cellulo and identify two lysine (K) residues (K205 and K273) as SUMOylation sites.	Lysine	108-114	HNF1 homeobox A	Homo sapiens	40-46
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Lysine	164-167	family with sequence similarity 72 member B	Homo sapiens	0-3
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Lysine	164-167	cyclin dependent kinase 6	Homo sapiens	205-209
29756279-1	2018	A computationally designed, allosterically regulated catalyst (CaM M144H) produced by substituting a single residue in calmodulin, a non-enzymatic protein, is capable of efficient and site selective post-translational acylation of lysines in peptides with highly diverse sequences.	Lysine	231-238	calmodulin 1	Homo sapiens	119-129
29758299-8	2018	Mechanistically, NOXA is hijacked by p62 as autophagic cargo, and its three lysine residues at the C-terminus are necessary for NOXA degradation in lysosomes.	Lysine	76-82	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	17-21
30072621-0	2018	Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3.	Lysine	103-109	CREB binding protein	Homo sapiens	13-16
30072621-0	2018	Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3.	Lysine	103-109	tumor protein p53	Homo sapiens	57-60
30159125-1	2018	Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134 and enhance the formation of phosphorylated H2AX (gamma-H2AX), which causes chemoresistance of cancer cells.	Lysine	76-82	H2A.X variant histone	Mus musculus	68-72
30159125-1	2018	Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134 and enhance the formation of phosphorylated H2AX (gamma-H2AX), which causes chemoresistance of cancer cells.	Lysine	76-82	H2A.X variant histone	Mus musculus	131-135
30159125-1	2018	Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134 and enhance the formation of phosphorylated H2AX (gamma-H2AX), which causes chemoresistance of cancer cells.	Lysine	76-82	H2A.X variant histone	Mus musculus	137-147
30071900-7	2018	Molecularly, EZH2 interacted with PCNA via the PIP box and dimethylated PCNA at lysine 110.	Lysine	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
29506216-0	2018	Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome.	Lysine	43-49	H2B clustered histone 1	Rattus norvegicus	29-36
29758299-8	2018	Mechanistically, NOXA is hijacked by p62 as autophagic cargo, and its three lysine residues at the C-terminus are necessary for NOXA degradation in lysosomes.	Lysine	76-82	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	128-132
30140388-9	2018	Mechanistically, HERC1 controls C-RAF stability by regulating its polyubiquitylation in a lysine 48-linked chain.	Lysine	90-96	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	Homo sapiens	17-22
29752946-10	2018	The amino acids hydroxyproline, proline, lysine, glycine and alanine induced the triglyceride accumulation and expression of Adiponectin.	Lysine	41-47	adiponectin, C1Q and collagen domain containing	Homo sapiens	125-136
29752946-12	2018	TGFbeta mRNA expression showed a significant decrease with proline, alanine, glycine, lysine and isoleucine.	Lysine	86-92	transforming growth factor beta 1	Homo sapiens	0-7
29752946-15	2018	DISCUSSION AND CONCLUSION: Our results suggest that amino acids hydroxyproline, proline, lysine, glycine and alanine which are elevated in the PDR vitreous show a tendency to induce adipogenic effects in retinal pericytes by triggering the accumulation of triglycerides and adiponectin.	Lysine	89-95	adiponectin, C1Q and collagen domain containing	Homo sapiens	274-285
29758466-2	2018	Among these proteins, the epigenetic reader, CREB-binding protein (CREBBP) bromodomain is one of the most prominent targets for effective anticancer drug design, which is responsible for the reorganization of acetylated histone lysine residues.	Lysine	228-234	CREB binding protein	Homo sapiens	45-65
29758466-2	2018	Among these proteins, the epigenetic reader, CREB-binding protein (CREBBP) bromodomain is one of the most prominent targets for effective anticancer drug design, which is responsible for the reorganization of acetylated histone lysine residues.	Lysine	228-234	CREB binding protein	Homo sapiens	67-73
30069026-5	2018	Defective NLRP3 sumoylation, either by NLRP3 mutation of SUMO acceptor lysines or depletion of MAPL, results in enhanced caspase-1 activation and IL-1beta release.	Lysine	71-78	NLR family pyrin domain containing 3	Homo sapiens	10-15
29596991-5	2018	In this study, we report that Lysine 86 in IL15 is responsible for the instability in mammalian cells when its C-terminus is fused to the albumin binding scFv (IL15-A10m3).	Lysine	30-36	immunglobulin heavy chain variable region	Homo sapiens	154-158
30012592-1	2018	The importance of BET protein BRD4 in gene transcription is well recognized through the study of chemical modulation of its characteristic tandem bromodomain (BrD) binding to lysine-acetylated histones and transcription factors.	Lysine	175-181	bromodomain containing 4	Homo sapiens	30-34
29589263-7	2018	Lys variant levels were positively related to the Lys and Arg concentrations in the medium and negatively related to carboxypeptidase B and carboxypeptidase H transcript levels.	Lysine	0-3	carboxypeptidase B	Cricetulus griseus	117-135
30047986-5	2018	Although there is a conserved Arg/Lys rich motif in the Hif-3alpha N-terminal region, deletion of this region has minimal effect on Hif-3alpha nuclear localization.	Lysine	34-37	hypoxia inducible factor 3 subunit alpha	Homo sapiens	56-66
30057418-13	2018	Instead, p53 acetylation at lysine 382 was unexpectedly upregulated.	Lysine	28-34	tumor protein p53	Homo sapiens	9-12
30094379-5	2018	We present evidence that SUMOylation of Glis3 by PIAS-family proteins occurs at two conserved lysine residues within the Glis3 N-terminus and modification of Glis3 by SUMO dramatically inhibited insulin transcription.	Lysine	94-100	insulin	Homo sapiens	195-202
29860315-3	2018	The lysine methyltransferases G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha at lysine (K) 674 in vitro and in vivo.	Lysine	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-86
29860315-3	2018	The lysine methyltransferases G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha at lysine (K) 674 in vitro and in vivo.	Lysine	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-98
29860315-3	2018	The lysine methyltransferases G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha at lysine (K) 674 in vitro and in vivo.	Lysine	4-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-152
29970899-6	2018	In a mechanistic manner, we also showed that SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 (EZH2, which is regarded as the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), specifying the histone alteration pattern on the target genes, including CDKN1A, and, as a result, altered the CCA cell biology.	Lysine	321-327	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	123-127
30022044-2	2018	EZH2 has been mainly studied as the catalytic component of the Polycomb Repressive Complex 2 (PRC2) that mediates gene repression by trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
29941599-2	2018	The methylation of histone H3 at Lys-27 catalyzed by the methyltransferase EZH2 was known to suppress gene expression and cancer development, and we previously reported that the O-GlcNAcylation of EZH2 at S76 stabilized EZH2 and facilitated the formation of H3K27me3 to inhibit tumor suppression.	Lysine	33-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	75-79
29941599-2	2018	The methylation of histone H3 at Lys-27 catalyzed by the methyltransferase EZH2 was known to suppress gene expression and cancer development, and we previously reported that the O-GlcNAcylation of EZH2 at S76 stabilized EZH2 and facilitated the formation of H3K27me3 to inhibit tumor suppression.	Lysine	33-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	197-201
29941599-2	2018	The methylation of histone H3 at Lys-27 catalyzed by the methyltransferase EZH2 was known to suppress gene expression and cancer development, and we previously reported that the O-GlcNAcylation of EZH2 at S76 stabilized EZH2 and facilitated the formation of H3K27me3 to inhibit tumor suppression.	Lysine	33-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	197-201
30288233-3	2018	After anchoring to cetuximab through amide bond with lysines, the resulting HDAC inhibitor-antibody conjugates showed ability to recognize EGFR and efficient internalization in tumor cells.	Lysine	53-60	epidermal growth factor receptor	Homo sapiens	139-143
29770599-2	2018	The bromodomains of BAZ2A and BAZ2B have a similar binding site for their natural ligand, the acetylated lysine side chain.	Lysine	105-111	bromodomain adjacent to zinc finger domain 2A	Homo sapiens	20-25
29996811-2	2018	A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in different cancers by inhibiting MYC oncogene.	Lysine	86-92	bromodomain containing 4	Homo sapiens	48-52
29856130-4	2018	A 18 nm tankyrase-1 binder featured l-lysine as linking moiety, while molecules based on d-Lysine or (2S,4S)-amino-l-proline showed no detectable binding to the target.	Lysine	36-44	tankyrase	Homo sapiens	8-19
30448236-6	2018	Furtherly, inhibition of SphK2 inactivated STAT3 by decreasing both phosphorylation on Tyr705 and acetylation on lysine residue, and led to stimulation of PEPCK and G6Pase expression.	Lysine	113-119	signal transducer and activator of transcription 3	Homo sapiens	43-48
29627904-4	2018	The 166 amino acids polypeptide chain of IFN beta-1a contains 11 Lys and 11 Gln residues potential sites of TGase derivatization.	Lysine	65-68	interferon alpha 1	Homo sapiens	41-44
29943287-2	2018	In this work, modifications of the lysine in SP by homocysteine and an acetyl group as well as the conformational dynamics of the native and modified SP peptides and their complexes with the NK1 receptor were studied via MD simulation.	Lysine	35-41	tachykinin precursor 1	Homo sapiens	45-47
29880196-5	2018	Mutations of lysine residues in calmodulin binding site 2 strongly reduced calmodulin binding and TRPM3 activity indicating the importance of this domain for TRPM3-mediated Ca2+ signaling.	Lysine	13-19	calmodulin 1	Homo sapiens	32-42
29880196-5	2018	Mutations of lysine residues in calmodulin binding site 2 strongly reduced calmodulin binding and TRPM3 activity indicating the importance of this domain for TRPM3-mediated Ca2+ signaling.	Lysine	13-19	calmodulin 1	Homo sapiens	75-85
29695490-4	2018	We found that deleting a H3 histone acetyltransferase Gcn5 or mutating lysines on the H3 tail impairs FACT recruitment at ADH1 and ARG1 genes.	Lysine	71-78	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	122-126
29743353-9	2018	Mutation analyses of all the lysine residues of MAVS further revealed that Lys325 of MAVS is catalyzed by TRIM21 for the K27-linked polyubiquitination.	Lysine	29-35	tripartite motif containing 21	Homo sapiens	106-112
29425687-5	2018	Mutation of lysine-679 on the sumoylation site of the STAT3 effectively blocked the ASC-J9 -suppressed PCa cell invasion in both in vitro cell lines and in vivo mouse models.	Lysine	12-18	signal transducer and activator of transcription 3	Mus musculus	54-59
29274298-6	2018	This allows monitoring the dynamic progress of the conversion of lysine to cadaverine with a temporal resolution of ~30 s. Moreover, the method only requires to sample the very early onset of the reaction (&lt;0.5% of substrate conversion where the host itself is required only at muM concentrations) at comparatively low reaction rates, thus saving enzyme material and reducing NMR acquisition time.	Lysine	65-71	latexin	Homo sapiens	281-284
29803980-5	2018	METHODS: Conjugate was prepared by Lys-Lys cross-linking of thrombin with the phosphatidylserine-targeting ligand, annexin V.	Lysine	35-38	coagulation factor II, thrombin	Homo sapiens	60-68
29803980-5	2018	METHODS: Conjugate was prepared by Lys-Lys cross-linking of thrombin with the phosphatidylserine-targeting ligand, annexin V.	Lysine	39-42	coagulation factor II, thrombin	Homo sapiens	60-68
29943287-8	2018	Modification of the lysine of SP decreases the binding affinity of the peptide to the NK1 receptor.	Lysine	20-26	tachykinin precursor 1	Homo sapiens	30-32
29943287-13	2018	Therefore, in this work, the lysine (LYS) in SP was theoretically modified with a homocysteine or acetyl group to explore the effects of such a modification on the binding affinity of this peptide with the NK1 receptor and the structural dynamics of the resulting complex.	Lysine	29-35	tachykinin precursor 1	Homo sapiens	45-47
29943287-13	2018	Therefore, in this work, the lysine (LYS) in SP was theoretically modified with a homocysteine or acetyl group to explore the effects of such a modification on the binding affinity of this peptide with the NK1 receptor and the structural dynamics of the resulting complex.	Lysine	37-40	tachykinin precursor 1	Homo sapiens	45-47
29925347-2	2018	These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; however, they are inactive outside of a multi-protein complex that requires WDR5.	Lysine	60-66	WD repeat domain 5	Homo sapiens	192-196
29942010-6	2018	Conversely, upon glucose starvation, SRSF5 is deacetylated by HDAC1, and ubiquitylated by Smurf1 on the same lysine, resulting in proteasomal degradation of SRSF5.	Lysine	109-115	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	90-96
29535128-5	2018	Mutagenesis of the acetylated lysine decreases RIP1-dependent cell death, suggesting a role for acetylation of the RIP1 complex in cell death modulation.	Lysine	30-36	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	47-51
29618057-8	2018	Consequently, in differentiating myoblasts, chemical inhibition of LSD1, in combination with Dex treatment, synergistically de-repressed oxidative metabolism genes, concomitant with increased histone H3 lysine 4 methylation at these loci.	Lysine	203-209	lysine (K)-specific demethylase 1A	Mus musculus	67-71
29916805-1	2018	Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene.	Lysine	89-95	lysine (K)-specific methyltransferase 2A	Mus musculus	33-37
29884816-4	2018	Based on structural differences in the substrate binding pockets to either side of the P1 Arg, we mutated the P2 and P1" residues to Lys.	Lysine	133-136	inorganic pyrophosphatase 1	Homo sapiens	110-120
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	H2A.Z variant histone 1	Mus musculus	84-89
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	H2A.Z variant histone 1	Mus musculus	209-214
29712723-8	2018	Further, HDL exposed to myeloperoxidase had elevated IsoLG-lysine adducts (5.7 ng/mg protein) compared with unexposed HDL (0.5 ng/mg protein).	Lysine	59-65	myeloperoxidase	Homo sapiens	24-39
29712772-5	2018	Furthermore, we demonstrated that SOCS1- and SOCS3-bound IFN regulatory factor 7, a pivotal transcription factor of the TLR7 pathway, through the SH2 domain to promote its proteasomal degradation by lysine 48-linked polyubiquitination.	Lysine	199-205	toll like receptor 7	Homo sapiens	120-124
29716999-2	2018	SET domain-containing 2 (SETD2) is the predominant histone methyltransferase catalyzing the trimethylation of histone H3 lysine 36 (H3K36me3) and plays key roles in embryonic stem cell differentiation and somatic cell development.	Lysine	121-127	SET domain containing 2	Mus musculus	0-23
29716999-2	2018	SET domain-containing 2 (SETD2) is the predominant histone methyltransferase catalyzing the trimethylation of histone H3 lysine 36 (H3K36me3) and plays key roles in embryonic stem cell differentiation and somatic cell development.	Lysine	121-127	SET domain containing 2	Mus musculus	25-30
29678881-5	2018	In the absence of traptamers, substitution of Lys197 to an uncharged amino acid increased CCR5 stability, and introduction of a lysine at the homologous position in CCR2b, a related chemokine receptor, decreased CCR2b levels.	Lysine	128-134	C-C motif chemokine receptor 2	Homo sapiens	165-170
29678881-5	2018	In the absence of traptamers, substitution of Lys197 to an uncharged amino acid increased CCR5 stability, and introduction of a lysine at the homologous position in CCR2b, a related chemokine receptor, decreased CCR2b levels.	Lysine	128-134	C-C motif chemokine receptor 2	Homo sapiens	212-217
29678583-2	2018	Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENP1.	Lysine	52-58	SUMO specific peptidase 1	Homo sapiens	93-98
29875445-6	2018	By mobilizing the nascent chain, CAT tailing can expose lysine residues that are hidden in the exit tunnel, thereby supporting efficient ubiquitination.	Lysine	56-62	catalase	Homo sapiens	33-36
29576612-1	2018	Polycomb repressive complex 2 (PRC2) member enhancer of zeste homolog 2 (EZH2) trimethylates histone H3 lysine 27 (H3K27me3), alters chromatin structure and contributes to epigenetic regulation of gene expression in normal and disease processes.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	44-71
29531159-8	2018	Thus, c-Src acetylation in the N-terminal and C-terminal domains play distinct roles in Src activity and regulation.Significance: CBP-mediated acetylation of lysine clusters in both the N-terminal and C-terminal regions of c-Src provides additional levels of control over STAT3 transcriptional activity.	Lysine	158-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	6-11
29531159-8	2018	Thus, c-Src acetylation in the N-terminal and C-terminal domains play distinct roles in Src activity and regulation.Significance: CBP-mediated acetylation of lysine clusters in both the N-terminal and C-terminal regions of c-Src provides additional levels of control over STAT3 transcriptional activity.	Lysine	158-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	8-11
29531159-8	2018	Thus, c-Src acetylation in the N-terminal and C-terminal domains play distinct roles in Src activity and regulation.Significance: CBP-mediated acetylation of lysine clusters in both the N-terminal and C-terminal regions of c-Src provides additional levels of control over STAT3 transcriptional activity.	Lysine	158-164	CREB binding protein	Homo sapiens	130-133
29531159-8	2018	Thus, c-Src acetylation in the N-terminal and C-terminal domains play distinct roles in Src activity and regulation.Significance: CBP-mediated acetylation of lysine clusters in both the N-terminal and C-terminal regions of c-Src provides additional levels of control over STAT3 transcriptional activity.	Lysine	158-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	223-228
29531159-8	2018	Thus, c-Src acetylation in the N-terminal and C-terminal domains play distinct roles in Src activity and regulation.Significance: CBP-mediated acetylation of lysine clusters in both the N-terminal and C-terminal regions of c-Src provides additional levels of control over STAT3 transcriptional activity.	Lysine	158-164	signal transducer and activator of transcription 3	Homo sapiens	272-277
29537081-10	2018	The tumor-suppressive effects of PCDHB3 are partially due to inhibition of NF-kappaB transcriptional activity through K63 deubiquitination of p50 at lysine 244/252, which increases the binding affinity of inactive p50 homodimer to kappaB DNA, resulting in competitive inhibition of the transcription of NF-kappaB target genes by p65 dimers.	Lysine	149-155	protocadherin beta 3	Homo sapiens	33-39
29537081-10	2018	The tumor-suppressive effects of PCDHB3 are partially due to inhibition of NF-kappaB transcriptional activity through K63 deubiquitination of p50 at lysine 244/252, which increases the binding affinity of inactive p50 homodimer to kappaB DNA, resulting in competitive inhibition of the transcription of NF-kappaB target genes by p65 dimers.	Lysine	149-155	nuclear factor kappa B subunit 1	Homo sapiens	142-145
29506078-3	2018	Here we find that METTL3 is modified by SUMO1 mainly at lysine residues K177, K211, K212 and K215, which can be reduced by an SUMO1-specific protease SENP1.	Lysine	56-62	SUMO specific peptidase 1	Homo sapiens	150-155
29730439-1	2018	The binding affinity between the histone 3 (H3) tail and the ADD domain of ATRX (ATRXADD) increases with the subsequent addition of methyl groups on lysine 9 on H3.	Lysine	149-155	H3 clustered histone 14	Homo sapiens	33-46
29730439-1	2018	The binding affinity between the histone 3 (H3) tail and the ADD domain of ATRX (ATRXADD) increases with the subsequent addition of methyl groups on lysine 9 on H3.	Lysine	149-155	H3 clustered histone 14	Homo sapiens	44-46
29531159-4	2018	In EGF-treated cells, CREB binding protein (CBP) acetylates an N-terminal lysine cluster (K5, K7, and K9) of c-Src to promote dissociation from the cell membrane.	Lysine	74-80	CREB binding protein	Homo sapiens	22-42
29531159-4	2018	In EGF-treated cells, CREB binding protein (CBP) acetylates an N-terminal lysine cluster (K5, K7, and K9) of c-Src to promote dissociation from the cell membrane.	Lysine	74-80	CREB binding protein	Homo sapiens	44-47
29531159-4	2018	In EGF-treated cells, CREB binding protein (CBP) acetylates an N-terminal lysine cluster (K5, K7, and K9) of c-Src to promote dissociation from the cell membrane.	Lysine	74-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	109-114
29571013-7	2018	In the ternary complex model of Sirt4-NAD+-GDH, the acetylated lysine 171 of GDH is located close to NAD+.	Lysine	63-69	sirtuin 4	Homo sapiens	32-46
29858084-9	2018	Ultimately, miR372 promotes the expression of erbB-2 through PKM2-pH3T11-acetylation on histone H3 lysine 9 (H3K9Ac) pathway.	Lysine	99-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-52
29576612-1	2018	Polycomb repressive complex 2 (PRC2) member enhancer of zeste homolog 2 (EZH2) trimethylates histone H3 lysine 27 (H3K27me3), alters chromatin structure and contributes to epigenetic regulation of gene expression in normal and disease processes.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77
29645318-8	2018	Using HX-MS, we find other poly anions tested bind in a similar manner to heparin, primarily targeting the turns in the lysine rich C-terminal region of FGF-1 along with two distinct N-terminal regions that contains lysines and arginines/histidines.	Lysine	120-126	fibroblast growth factor 1	Homo sapiens	153-158
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Lysine	44-50	protein arginine methyltransferase 5	Homo sapiens	72-108
29765032-2	2018	PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has been sub-classified into six major complexes based on the presence of a PCGF subunit.	Lysine	62-68	ring finger protein 1	Mus musculus	29-37
29844424-9	2018	Moreover, the histone 3 lysine 27 acetylation (H3K27ac) level in angiotensin-converting enzyme (ACE) promoter region was increased by PDE from GD20 to PW12.	Lysine	24-30	angiotensin I converting enzyme	Rattus norvegicus	65-94
29844424-9	2018	Moreover, the histone 3 lysine 27 acetylation (H3K27ac) level in angiotensin-converting enzyme (ACE) promoter region was increased by PDE from GD20 to PW12.	Lysine	24-30	angiotensin I converting enzyme	Rattus norvegicus	96-99
29769606-0	2018	Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.	Lysine	31-37	protein kinase BUB1	Saccharomyces cerevisiae S288C	51-55
29664630-5	2018	NMR methodology was employed for determining the dynamics of lysine side-chain amino groups via 15N relaxation measurements in the Lys50-class homeodomains from the Drosophila protein Bicoid and the human protein Pitx2.	Lysine	61-67	bicoid	Drosophila melanogaster	184-190
29664630-5	2018	NMR methodology was employed for determining the dynamics of lysine side-chain amino groups via 15N relaxation measurements in the Lys50-class homeodomains from the Drosophila protein Bicoid and the human protein Pitx2.	Lysine	61-67	paired like homeodomain 2	Homo sapiens	213-218
29712868-6	2018	Of these, 46 make physical contact with INS We analyze a subset of the contacted genes and show that all are associated with acetylation of histone H3 lysine 27, a marker of actively expressed genes.	Lysine	151-157	insulin	Homo sapiens	40-43
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-148
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	150-154
29742153-1	2018	WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors.	Lysine	88-94	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
29430821-0	2018	Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity.	Lysine	12-18	cathelicidin antimicrobial peptide	Homo sapiens	32-37
29330215-9	2018	Proteomic analysis of the total acetylome showed increased overall acetylation, and specific lysine acetylation of 2 central mitochondrial metabolic enzymes, PDH and ATP synthase, as well.	Lysine	93-99	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	158-161
28945358-6	2018	Mutation of CTD lysines in heptad position 7 to consensus serines reduced the overall level of TAF15 fibril binding, suggesting that electrostatic interactions contribute to complex formation.	Lysine	16-23	CTD	Homo sapiens	12-15
29628311-1	2018	The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3.	Lysine	157-163	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	92-98
29294058-3	2018	An alternative splicing of Wt1 can add three additional amino acids-lysine (K), threonine (T) and serine (S)-between ZF3 and ZF4.	Lysine	68-74	WT1 transcription factor	Homo sapiens	27-30
29294297-4	2018	In this research, we found that EZH2 expression decreased during the mineralization of hDPCs, with attenuated H3K27me3 (trimethylation on lysine 27 in histone H3).	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
29719249-2	2018	Here, we identify METTL21C as a skeletal muscle-specific lysine methyltransferase.	Lysine	57-63	methyltransferase 21C, AARS1 lysine	Homo sapiens	18-26
29248547-3	2018	Here we report that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 lysine 27 trimethylation, is overexpressed in CD30+ anaplastic cells in primary cutaneous anaplastic T-cell lymphoma and large-cell transformed cutaneous T-cell lymphoma.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	20-47
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	49-55	casein beta	Bos taurus	96-100
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	57-60	casein beta	Bos taurus	96-100
29248547-3	2018	Here we report that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 lysine 27 trimethylation, is overexpressed in CD30+ anaplastic cells in primary cutaneous anaplastic T-cell lymphoma and large-cell transformed cutaneous T-cell lymphoma.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	49-53
28540657-5	2018	By reducing the production of lysine (K63)-linked ubiquitin chains, UCH-L1 inhibition decreases HDAC6 deacetylase activity and attenuates the interaction of HDAC6 and tau protein, finally leading to tau aggresome formation impairment.	Lysine	30-36	histone deacetylase 6	Homo sapiens	96-101
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Lysine	48-54	defensin beta 1	Homo sapiens	100-103
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Lysine	48-54	defensin beta 4A	Homo sapiens	122-125
29605436-2	2018	BET proteins contain two tandem bromodomains (BD1 and BD2) that independently recognize acetylated-lysine residues and appear to have distinct biological roles.	Lysine	99-105	defensin beta 1	Homo sapiens	46-49
29605436-2	2018	BET proteins contain two tandem bromodomains (BD1 and BD2) that independently recognize acetylated-lysine residues and appear to have distinct biological roles.	Lysine	99-105	defensin beta 4A	Homo sapiens	54-57
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Lysine	48-54	defensin beta 4A	Homo sapiens	58-61
29438996-6	2018	Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex.	Lysine	80-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	191-194
29438996-6	2018	Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex.	Lysine	80-86	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	222-225
28540657-5	2018	By reducing the production of lysine (K63)-linked ubiquitin chains, UCH-L1 inhibition decreases HDAC6 deacetylase activity and attenuates the interaction of HDAC6 and tau protein, finally leading to tau aggresome formation impairment.	Lysine	30-36	histone deacetylase 6	Homo sapiens	157-162
29511085-9	2018	To identify the amino acid residue that is targeted by TRIM21, we fragmented the SALL4B sequence, fused it to EGFP, and identified Lys-190 in SALL4B as TRIM21"s target residue.	Lysine	131-134	tripartite motif containing 21	Homo sapiens	55-61
29520963-8	2018	The integrated approach reported here has the potential for large-scale prioritization of in situ crosstalk of PLM candidates and provides a profound understanding of the underlying relationship between different lysine modifications.	Lysine	213-219	FXYD domain containing ion transport regulator 1	Homo sapiens	111-114
29695657-6	2018	Importantly, the IL-6 gene promoter contains a single nucleotide polymorphism (SNP), -572C/G, and ICAM-1 gene contains a SNP (A/G) in the protein-coding region, Lys (AAG)/Glu (GAG) at codon 469, known as K469E polymorphism.	Lysine	161-164	interleukin 6	Homo sapiens	17-21
29496995-3	2018	This work demonstrates that the heme protein myeloperoxidase (MPO), which is secreted at high concentrations at inflammatory sites from stimulated neutrophils and monocytes, is able to catalyze the two-electron oxidation of cyanide to cyanate and promote the carbamylation of taurine, lysine, and low-density lipoproteins.	Lysine	285-291	myeloperoxidase	Homo sapiens	45-60
29496995-3	2018	This work demonstrates that the heme protein myeloperoxidase (MPO), which is secreted at high concentrations at inflammatory sites from stimulated neutrophils and monocytes, is able to catalyze the two-electron oxidation of cyanide to cyanate and promote the carbamylation of taurine, lysine, and low-density lipoproteins.	Lysine	285-291	myeloperoxidase	Homo sapiens	62-65
29511085-9	2018	To identify the amino acid residue that is targeted by TRIM21, we fragmented the SALL4B sequence, fused it to EGFP, and identified Lys-190 in SALL4B as TRIM21"s target residue.	Lysine	131-134	tripartite motif containing 21	Homo sapiens	152-158
29672562-8	2018	In the incubation of human serum albumin (HSA) with ONE or HNE, Lys residues provided the most favorable modification sites for both aldehydes, and the number of HNE-modified sites was higher than that of ONE-modified sites.	Lysine	64-67	albumin	Homo sapiens	27-40
29897602-3	2018	Here, we show that TFAM is lysine acetylated within its high-mobility-group box 1, a domain that can also be serine phosphorylated.	Lysine	27-33	transcription factor A, mitochondrial	Homo sapiens	19-23
29703894-1	2018	Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3).	Lysine	145-151	SET domain, bifurcated 1	Mus musculus	110-116
29853810-1	2018	Objective: To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts.	Lysine	39-42	folate hydrolase 1	Homo sapiens	62-66
29853810-1	2018	Objective: To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts.	Lysine	39-42	folate hydrolase 1	Homo sapiens	137-141
29691401-2	2018	Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves epigenetic inheritance of DNA methylation patterns during DNA replication, is demethylated by LSD1.	Lysine	36-42	DNA methyltransferase (cytosine-5) 1	Mus musculus	50-58
29691401-2	2018	Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves epigenetic inheritance of DNA methylation patterns during DNA replication, is demethylated by LSD1.	Lysine	36-42	lysine (K)-specific demethylase 1A	Mus musculus	196-200
29444827-9	2018	Of note, Lys-deficient PTHR mutants promoted normal cAMP formation, but exhibited differential mitogen-activated protein kinase (MAPK) signaling.	Lysine	9-12	parathyroid hormone 1 receptor	Homo sapiens	23-27
29670121-3	2018	TRPV1 is SUMOylated at a C-terminal Lys residue (K822), which specifically enhances the channel sensitivity to stimulation by heat, but not capsaicin, protons or voltage.	Lysine	36-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29662006-3	2018	We used the hyperinsulinemic non-obese FVB/N (Friend leukemia virus B strain) MKR (muscle (M)-IGF1R-lysine (K)-arginine (R) mouse model to evaluate the exclusive role of hyperinsulinemia in the pathogenesis of EAC related to duodeno-esophageal reflux.	Lysine	100-106	insulin-like growth factor I receptor	Mus musculus	94-99
29669288-3	2018	Mechanistic studies revealed that TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine.	Lysine	176-182	tripartite motif containing 9	Homo sapiens	34-39
29669288-3	2018	Mechanistic studies revealed that TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine.	Lysine	176-182	mitogen-activated protein kinase kinase 6	Homo sapiens	83-87
29669288-3	2018	Mechanistic studies revealed that TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine.	Lysine	176-182	mitogen-activated protein kinase kinase 6	Homo sapiens	159-163
29774081-10	2018	G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth.	Lysine	24-30	tumor protein p53	Homo sapiens	17-20
29444827-9	2018	Of note, Lys-deficient PTHR mutants promoted normal cAMP formation, but exhibited differential mitogen-activated protein kinase (MAPK) signaling.	Lysine	9-12	mitogen-activated protein kinase 3	Homo sapiens	129-133
29444827-10	2018	Lys-deficient PTHR triggered early onset and delayed ERK1/2 signaling compared with wildtype PTHR.	Lysine	0-3	parathyroid hormone 1 receptor	Homo sapiens	14-18
29444827-10	2018	Lys-deficient PTHR triggered early onset and delayed ERK1/2 signaling compared with wildtype PTHR.	Lysine	0-3	mitogen-activated protein kinase 3	Homo sapiens	53-59
29444827-11	2018	Moreover, ubiquitination of Lys388 and Lys484 in wildtype PTHR strongly decreased p38 signaling, whereas Lys-deficient PTHR retained signaling comparable to unstimulated wildtype PTHR.	Lysine	28-31	parathyroid hormone 1 receptor	Homo sapiens	58-62
29444827-11	2018	Moreover, ubiquitination of Lys388 and Lys484 in wildtype PTHR strongly decreased p38 signaling, whereas Lys-deficient PTHR retained signaling comparable to unstimulated wildtype PTHR.	Lysine	28-31	mitogen-activated protein kinase 1	Homo sapiens	82-85
29444827-12	2018	Lys-deficient, ubiquitination-refractory PTHR reduced cell proliferation and increased apoptosis.	Lysine	0-3	parathyroid hormone 1 receptor	Homo sapiens	41-45
29444827-13	2018	However, elimination of all 11 Lys residues in PTHR did not affect its internalization and recycling.	Lysine	31-34	parathyroid hormone 1 receptor	Homo sapiens	47-51
29444827-14	2018	These results pinpoint the ubiquitinated Lys residues in PTHR controlling MAPK signaling and cell proliferation and survival.	Lysine	41-44	parathyroid hormone 1 receptor	Homo sapiens	57-61
29444827-14	2018	These results pinpoint the ubiquitinated Lys residues in PTHR controlling MAPK signaling and cell proliferation and survival.	Lysine	41-44	mitogen-activated protein kinase 3	Homo sapiens	74-78
29581290-1	2018	The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport.	Lysine	12-18	serine/threonine kinase 39	Homo sapiens	103-107
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	nitric oxide synthase 2	Homo sapiens	23-27
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	bromodomain containing 4	Homo sapiens	226-230
32254364-4	2018	In this work, inspired by the statherin in the salivary acquired pellicle, we designed a simple peptide sequence, Asp-Asp-Asp-Glu-Glu-Lys-Cys (peptide-7), to accomplish the dual tasks of adsorption and mineralization on enamel surfaces.	Lysine	134-137	statherin	Homo sapiens	30-39
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	nitric oxide synthase 2	Homo sapiens	267-271
29523590-3	2018	Ezh2 is a key enzymatic component of polycomb repressive complex 2 (PRC2), which silences gene expression by histone H3 di/tri-methylation at lysine 27.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
29615062-1	2018	BACKGROUND: KARS encodes lysyl- transfer ribonucleic acid (tRNA) synthetase, which catalyzes the aminoacylation of tRNA-Lys in the cytoplasm and mitochondria.	Lysine	120-123	lysyl-tRNA synthetase 1	Homo sapiens	12-16
29371232-3	2018	Mice deficient in the MHCII-ubiquitinating enzyme membrane-anchored RING-CH1, or the ubiquitin-acceptor lysine of MHCII, exhibit a substantial reduction in the number of regulatory T (Treg) cells, but the underlying mechanism was unclear.	Lysine	104-110	histocompatibility-2, MHC	Mus musculus	114-119
29427946-2	2018	More specifically, acryloyl derivatives of lysine, ornithine, cystine and cystamine, were employed as monomers and disulfide crosslinkers for non-covalent encapsulation of model protein bovine serum albumin (BSA) and were interfacially crosslinked via free radical polymerization to form redox-responsive protein NPs.	Lysine	43-49	albumin	Homo sapiens	193-206
29208611-10	2018	Hypoxia-inducible factor (HIF)-1alpha-regulated genes and histone H3 lysine 9 (H3K9) acetylation, a known sirtuin 6 (SIRT6) target, were increased in shNampt KD cells.	Lysine	69-75	sirtuin 6	Mus musculus	106-115
29208611-10	2018	Hypoxia-inducible factor (HIF)-1alpha-regulated genes and histone H3 lysine 9 (H3K9) acetylation, a known sirtuin 6 (SIRT6) target, were increased in shNampt KD cells.	Lysine	69-75	sirtuin 6	Mus musculus	117-122
29308622-11	2018	In addition, epigenetic marks of histone 3 lysine 9 acetylation (H3K9ac) and di-metylation (H3K9me2) showed significantly higher incorporations in the regulatory regions of the FMR1 gene, including the promoter and the exon 1, whereas tri-metylation (H3K9me3) mark showed no significant difference between two groups.	Lysine	43-49	fragile X messenger ribonucleoprotein 1	Homo sapiens	177-181
29053336-4	2018	By applying chromatin immunoprecipitation, Re-ChIP, and proximity ligation assays, we demonstrated that, like G9a-mediated H3K9 methylation, EZH2-mediated histone H3 lysine 27 trimethylation (H3K27me3) was significantly enriched at the CXCL10 promoter in fibroblasts from IPF lungs (F-IPF) compared with fibroblasts from nonfibrotic lungs, and we also found that EZH2 and G9a physically interacted with each other.	Lysine	166-172	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	141-145
29339121-6	2018	HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2.	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	98-125
29339121-6	2018	HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2.	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	127-131
29339121-6	2018	HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2.	Lysine	190-196	sorbin and SH3 domain containing 2	Homo sapiens	141-147
29330559-4	2018	In this issue of Diabetologia, He et al ( https://doi.org/10.1007/s00125-017-4523-9 ) show that post-translational attachment of small ubiquitin-like modifier (SUMO) to target lysine residues (SUMOylation) strikes an important balance between the protection of beta cells from oxidative stress and the maintenance of insulin secretory function.	Lysine	176-182	insulin	Homo sapiens	317-324
29593216-5	2018	Klf4 polyglutamylation at Glu381 by tubulin tyrosine ligase-like 4 (TTLL4) and TTLL1 during cell reprogramming impedes its lysine 48-linked ubiquitination and sustains Klf4 stability.	Lysine	123-129	Kruppel-like factor 4 (gut)	Mus musculus	0-4
29383875-1	2018	Ring 1 and YY1 binding protein (RYBP) was first identified in 1999, and its structure includes a conserved Npl4 Zinc finger motif at the N-terminus, a central region that is characteristically enriched with arginine and lysine residues and a C-terminal region enriched with serine and threonine amino acids.	Lysine	220-226	RING1 and YY1 binding protein	Homo sapiens	0-30
29383875-1	2018	Ring 1 and YY1 binding protein (RYBP) was first identified in 1999, and its structure includes a conserved Npl4 Zinc finger motif at the N-terminus, a central region that is characteristically enriched with arginine and lysine residues and a C-terminal region enriched with serine and threonine amino acids.	Lysine	220-226	RING1 and YY1 binding protein	Homo sapiens	32-36
29386291-11	2018	Moreover, we identified two target lysine residues, K110 and K140, which are essential for both porcine ASC ubiquitination and NLRP3 inflammasome-mediated IL-1beta production.	Lysine	35-41	PYD and CARD domain containing	Homo sapiens	104-107
29386291-11	2018	Moreover, we identified two target lysine residues, K110 and K140, which are essential for both porcine ASC ubiquitination and NLRP3 inflammasome-mediated IL-1beta production.	Lysine	35-41	NLR family pyrin domain containing 3	Homo sapiens	127-132
29386291-11	2018	Moreover, we identified two target lysine residues, K110 and K140, which are essential for both porcine ASC ubiquitination and NLRP3 inflammasome-mediated IL-1beta production.	Lysine	35-41	interleukin 1 beta	Homo sapiens	155-163
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	18-24	AKT serine/threonine kinase 1	Homo sapiens	76-79
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	18-24	AKT serine/threonine kinase 1	Homo sapiens	112-115
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	133-139	AKT serine/threonine kinase 1	Homo sapiens	76-79
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	133-139	AKT serine/threonine kinase 1	Homo sapiens	112-115
29421189-2	2018	UTX removes di- and trimethyl groups on histone H3 lysine 27, thereby regulating gene expression.	Lysine	51-57	lysine demethylase 6A	Homo sapiens	0-3
29553265-0	2018	Correction to "A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch".	Lysine	64-70	cytochrome c, somatic	Homo sapiens	38-50
29358331-5	2018	We found that LSD1 not only removes the methyl group from monomethylated Lys-117 (equivalent to Lys-119 in mouse SOX2), but it also demethylates monomethylated Lys-42 in SOX2, a reaction that SET7 also regulated and that also triggered SOX2 proteolysis.	Lysine	73-76	lysine (K)-specific demethylase 1A	Mus musculus	14-18
29473744-11	2018	We showed that a protein-antibody conjugate bearing a site-specifically installed fluorophore at lysine could be used for selective imaging of apoptotic cells and detection of Her2+ cells, respectively.	Lysine	97-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	176-180
29545540-4	2018	Only cytoplasmic ubiquitylation targets Ascl1 for destruction, which occurs by conjugation of ubiquitin to lysines in the basic helix-loop-helix domain of Ascl1 and requires the E3 ligase Huwe1.	Lysine	107-114	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	188-193
29358331-5	2018	We found that LSD1 not only removes the methyl group from monomethylated Lys-117 (equivalent to Lys-119 in mouse SOX2), but it also demethylates monomethylated Lys-42 in SOX2, a reaction that SET7 also regulated and that also triggered SOX2 proteolysis.	Lysine	96-99	lysine (K)-specific demethylase 1A	Mus musculus	14-18
29358331-5	2018	We found that LSD1 not only removes the methyl group from monomethylated Lys-117 (equivalent to Lys-119 in mouse SOX2), but it also demethylates monomethylated Lys-42 in SOX2, a reaction that SET7 also regulated and that also triggered SOX2 proteolysis.	Lysine	96-99	lysine (K)-specific demethylase 1A	Mus musculus	14-18
29556394-1	2018	Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery.	Lysine	142-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
29495487-3	2018	Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79).	Lysine	121-127	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	6-10
29556394-1	2018	Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery.	Lysine	142-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29288497-3	2018	Most ARS genes in these cellular compartments are distinct, but two genes are common, encoding aminoacyl-tRNA synthetases of glycine (GARS) and lysine (KARS) in both mitochondria and the cytosol.	Lysine	144-150	lysyl-tRNA synthetase 1	Homo sapiens	152-156
29726819-6	2018	EZH2 is the enzymatic catalytic subunit of the PRC2 complex that can alter gene expression by trimethylating lysine 27 on histone 3 (H3K27).	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
29429936-4	2018	Mutating lysine at position 10 or lysine at position 11 of PSD-95 to glutamate, or glutamate at position 53 or glutamate and aspartate at positions 213 and 217 of alpha-actinin, respectively, to lysine impairs, in parallel, PSD-95 binding to alpha-actinin and postsynaptic localization of PSD-95 and AMPARs.	Lysine	9-15	actinin alpha 1	Homo sapiens	163-176
29453984-7	2018	Taken together, we demonstrated that GATA3 acetylation at lysine 119 by CBP hinders the migration and invasion of lung adenocarcinoma cells.	Lysine	58-64	CREB binding protein	Homo sapiens	72-75
29397952-4	2018	PafA couples ATP hydrolysis to formation of an isopeptide bond between Pup and a protein lysine via a mechanism similar to that used by glutamine synthetase (GS) to generate glutamine from ammonia and glutamate.	Lysine	89-95	glutamate-ammonia ligase	Homo sapiens	136-156
29636998-2	2018	Enhancer of zeste homolog 2 (EZH2) is the catalytic core protein in the polycomb repressive complex 2 (PRC2), which catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3) and mediates gene silencing of the target genes that are involved in fundamental cellular processes, such as the cell fate decision, cell cycle regulation, senescence, cell differentiation, and cancer formation.	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
29636998-2	2018	Enhancer of zeste homolog 2 (EZH2) is the catalytic core protein in the polycomb repressive complex 2 (PRC2), which catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3) and mediates gene silencing of the target genes that are involved in fundamental cellular processes, such as the cell fate decision, cell cycle regulation, senescence, cell differentiation, and cancer formation.	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29435063-1	2018	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase, which targets histone H3 lysine 27.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
29435063-1	2018	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase, which targets histone H3 lysine 27.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29490267-4	2018	Cytoplasmic MBNL1 is polyubiquitinated by lysine 63 (K63).	Lysine	42-48	muscleblind like splicing factor 1	Mus musculus	12-17
29495487-3	2018	Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79).	Lysine	121-127	DOT1 like histone lysine methyltransferase	Homo sapiens	39-44
29440432-7	2018	Surprisingly, we discovered that DTX1 depletion also elevates Notch1 activity mediated by a mutant form of the receptor that lacks lysine residues for ubiquitination, suggesting that DTX1 targets additional factors.	Lysine	131-137	notch receptor 1	Homo sapiens	62-68
29440439-5	2018	We show that a charge-conserved mutation of a lysine located on the surface of DD (K599R in human RIPK1 or K584R in murine RIPK1) blocks RIPK1 activation in necroptosis and RIPK1-dependent apoptosis and the formation of complex II.	Lysine	46-52	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	123-128
29440439-5	2018	We show that a charge-conserved mutation of a lysine located on the surface of DD (K599R in human RIPK1 or K584R in murine RIPK1) blocks RIPK1 activation in necroptosis and RIPK1-dependent apoptosis and the formation of complex II.	Lysine	46-52	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	123-128
29440439-5	2018	We show that a charge-conserved mutation of a lysine located on the surface of DD (K599R in human RIPK1 or K584R in murine RIPK1) blocks RIPK1 activation in necroptosis and RIPK1-dependent apoptosis and the formation of complex II.	Lysine	46-52	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	123-128
29448109-0	2018	HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue.	Lysine	107-113	histone deacetylase 1	Homo sapiens	0-5
29448109-0	2018	HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue.	Lysine	107-113	folate hydrolase 1	Homo sapiens	33-62
29448109-1	2018	Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG.	Lysine	184-190	folate hydrolase 1	Homo sapiens	44-73
29448109-1	2018	Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG.	Lysine	184-190	folate hydrolase 1	Homo sapiens	75-80
29448109-1	2018	Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG.	Lysine	184-190	folate hydrolase 1	Homo sapiens	206-211
29448109-4	2018	Overexpression of catalytic domain (1-56 aa)-deleted HDAC1, which poorly binds to GCPII, enhanced lysine acetylation in GCPII and increased the level of GCPII protein when compared with that of the wild-type HDAC1.	Lysine	98-104	histone deacetylase 1	Homo sapiens	53-58
29448109-8	2018	Further, database search of acetylation and ubiquitination sites showed four candidate lysine sites in human GCPII protein that can be both acetylated and ubiquitinylated (K207, K479, K491, and K699).	Lysine	87-93	folate hydrolase 1	Homo sapiens	109-114
29448109-9	2018	Mutation (lysine residues to arginine (R)) analysis showed that in the presence of cycloheximide K479R- and K491R-hGCPII mutants were less ubiquitinylated and degraded, and decrease in the level of GCPII protein by HDAC1 was significantly blocked by K479R mutants.	Lysine	10-16	folate hydrolase 1	Homo sapiens	115-120
29448109-11	2018	Furthermore, the results also demonstrate that the stability of GCPII protein is regulated by HDAC1 through acetylation at the lysine 479 residue.	Lysine	127-133	folate hydrolase 1	Homo sapiens	64-69
29448109-11	2018	Furthermore, the results also demonstrate that the stability of GCPII protein is regulated by HDAC1 through acetylation at the lysine 479 residue.	Lysine	127-133	histone deacetylase 1	Homo sapiens	94-99
29474358-11	2018	Importantly, the utilization of the same lithographic system for MEA fabrication and poly lysine structuring will make it easy to align the architecture of the neuronal network to the arrangement of the MEA electrode..	Lysine	90-96	male-enhanced antigen 1	Homo sapiens	203-206
29474172-5	2018	Mechanistically, SIRT6 deacetylates p53 at lysine 381 to negatively regulate the stability and activity of p53.	Lysine	43-49	sirtuin 6	Mus musculus	17-22
29475957-1	2018	The activity of human transglutaminase 2 (TG2), which forms protein cross-links between glutamine and lysine residues, is controlled by an allosteric disulfide bond.	Lysine	102-108	transglutaminase 2	Homo sapiens	22-40
29472543-5	2018	In this study, we found that trimethylation of several lysine sites of histone H3, including lysine 27 (H3K27me3), increased in the retinas of rd1 mice.	Lysine	55-61	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	143-146
29472543-5	2018	In this study, we found that trimethylation of several lysine sites of histone H3, including lysine 27 (H3K27me3), increased in the retinas of rd1 mice.	Lysine	93-99	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	143-146
29475957-1	2018	The activity of human transglutaminase 2 (TG2), which forms protein cross-links between glutamine and lysine residues, is controlled by an allosteric disulfide bond.	Lysine	102-108	transglutaminase 2	Homo sapiens	42-45
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	50-53	mitogen-activated protein kinase 1	Homo sapiens	87-91
29643974-2	2018	Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD+-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation.	Lysine	291-297	sirtuin 3	Homo sapiens	28-37
29643974-2	2018	Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD+-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation.	Lysine	291-297	sirtuin 3	Homo sapiens	39-44
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	50-53	mitogen-activated protein kinase 1	Homo sapiens	200-204
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	116-119	mitogen-activated protein kinase 1	Homo sapiens	87-91
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	116-119	mitogen-activated protein kinase 1	Homo sapiens	200-204
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	116-119	mitogen-activated protein kinase 1	Homo sapiens	87-91
29259132-9	2018	Furthermore, mass spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding.	Lysine	116-119	mitogen-activated protein kinase 1	Homo sapiens	200-204
29233865-5	2018	We show that MMSET is required for efficient NER and that it catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2).	Lysine	106-112	nuclear receptor binding SET domain protein 2	Homo sapiens	13-18
29415998-4	2018	Further study showed that CFTR expression is regulated by the interaction of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2), which, respectively, regulate DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	DNA methyltransferase (cytosine-5) 1	Mus musculus	77-100
29415998-4	2018	Further study showed that CFTR expression is regulated by the interaction of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2), which, respectively, regulate DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	DNA methyltransferase (cytosine-5) 1	Mus musculus	102-107
29416002-1	2018	Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 of histone H3, largely functions as a transcriptional repressor, and plays a critical role in various kinds of cancers.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
29416002-1	2018	Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 of histone H3, largely functions as a transcriptional repressor, and plays a critical role in various kinds of cancers.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29425510-5	2018	Structure-function analyses revealed similar N-C interaction in TRPP2 as well as TRPM8/-V1/-C4 via highly conserved tryptophan and lysine/arginine residues.	Lysine	131-137	polycystin 2, transient receptor potential cation channel	Homo sapiens	64-69
29288668-3	2018	In addition, Pex22p binding allows Pex4p to specifically produce lysine 48 linked ubiquitin chains in vitro through an unknown mechanism.	Lysine	65-71	ubiquitin-protein transferase activating protein PEX22	Saccharomyces cerevisiae S288C	13-19
29220567-1	2018	KDM subfamily 6 enzymes KDM6A and KDM6B specifically catalyze demethylation of di- and trimethylated lysine on histone 3 lysine 27 (H3K27me3/2) and play an important role in repression of developmental genes.	Lysine	101-107	lysine demethylase 6A	Homo sapiens	24-29
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
29278911-4	2018	PA1 peptide and its conjugate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator or fluorescein isothiocyanate (FITC) at the N-terminal of the lysine position were synthesized.	Lysine	170-176	PAXIP1 associated glutamate rich protein 1	Homo sapiens	0-3
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	interleukin 6	Homo sapiens	120-124
29402921-4	2018	Piglets fed the lysine-restricted diet exhibited overexpression of interleukin-8 (IL-8) in the kidney (P &lt; 0.05) and IL-6 and IL-4 in the spleen (P &lt; 0.05).	Lysine	16-22	interleukin 4	Homo sapiens	129-133
29402921-5	2018	The mRNA abundances of IL-4 in the kidney (P &lt; 0.05) and IL-10 in the liver (P &lt; 0.05) were significantly lower in the lysine-restricted group compared with the control group.	Lysine	125-131	interleukin 4	Homo sapiens	23-27
29402921-6	2018	Meanwhile, lysine restriction increased the mRNA level of Tlr8 in the kidney (P &lt; 0.05) but decreased the mRNA level of Tlr8 in the liver (P &lt; 0.05).	Lysine	11-17	toll like receptor 8	Homo sapiens	58-62
29402921-6	2018	Meanwhile, lysine restriction increased the mRNA level of Tlr8 in the kidney (P &lt; 0.05) but decreased the mRNA level of Tlr8 in the liver (P &lt; 0.05).	Lysine	11-17	toll like receptor 8	Homo sapiens	123-127
29456508-8	2018	We find that the distal benzoyl group of BzATP lies in close proximity to Lys-127, a residue previously implicated in BzATP binding to P2X7, potentially explaining the increased potency of BzATP at rat P2X7 receptors.	Lysine	74-77	purinergic receptor P2X 7	Homo sapiens	135-139
29456508-8	2018	We find that the distal benzoyl group of BzATP lies in close proximity to Lys-127, a residue previously implicated in BzATP binding to P2X7, potentially explaining the increased potency of BzATP at rat P2X7 receptors.	Lysine	74-77	purinergic receptor P2X 7	Homo sapiens	202-206
29402921-7	2018	Finally, lysine restriction markedly enhanced extracellular signal regulated kinases 1/2 (ERK1/2) phosphorylation in the kidney and liver and nuclear transcription factor kappa B (NF-kappaB) was activated in the liver and spleen in response to dietary lysine restriction.	Lysine	9-15	mitogen-activated protein kinase 1	Homo sapiens	46-88
29402921-7	2018	Finally, lysine restriction markedly enhanced extracellular signal regulated kinases 1/2 (ERK1/2) phosphorylation in the kidney and liver and nuclear transcription factor kappa B (NF-kappaB) was activated in the liver and spleen in response to dietary lysine restriction.	Lysine	9-15	mitogen-activated protein kinase 3	Homo sapiens	90-96
29402921-7	2018	Finally, lysine restriction markedly enhanced extracellular signal regulated kinases 1/2 (ERK1/2) phosphorylation in the kidney and liver and nuclear transcription factor kappa B (NF-kappaB) was activated in the liver and spleen in response to dietary lysine restriction.	Lysine	252-258	nuclear factor kappa B subunit 1	Homo sapiens	180-189
29402921-8	2018	In conclusion, lysine restriction affected inflammatory responses in the kidney, liver, and spleen via mediating serum antibody volume, inflammatory cytokines, Tlrs system, and ERK1/2 and NF-kappaB signals in piglets.	Lysine	15-21	mitogen-activated protein kinase 3	Homo sapiens	177-183
29402921-8	2018	In conclusion, lysine restriction affected inflammatory responses in the kidney, liver, and spleen via mediating serum antibody volume, inflammatory cytokines, Tlrs system, and ERK1/2 and NF-kappaB signals in piglets.	Lysine	15-21	nuclear factor kappa B subunit 1	Homo sapiens	188-197
29067790-4	2018	Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes.	Lysine	55-61	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	69-74
29067790-4	2018	Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes.	Lysine	55-61	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	76-86
29067790-4	2018	Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes.	Lysine	55-61	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	76-81
29155052-11	2018	Histidines and lysines in helices 5-8 of apoA-I were highly susceptible to oxPL modifications, while lysines in helices 1, 2, 4 and 10 were resistant to modification by oxPL.	Lysine	15-22	apolipoprotein A1	Homo sapiens	41-47
28984870-2	2018	Mass spectrometry demonstrated GADD34 acetylation at multiple lysines.	Lysine	62-69	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	31-37
29413895-3	2018	Here we show that histone 3 lysine 4 trimethylation (H3K4me3) modified by menin-MLL complex of IGF2 promoter contributes to promoter activity of IGF2.	Lysine	28-34	menin 1	Homo sapiens	74-79
29282851-1	2018	ESET protein (also known as SETDB1) catalyzes methylation of histone H3 at lysine 9 (H3-K9).	Lysine	75-81	SET domain, bifurcated 1	Mus musculus	0-4
29282851-1	2018	ESET protein (also known as SETDB1) catalyzes methylation of histone H3 at lysine 9 (H3-K9).	Lysine	75-81	SET domain, bifurcated 1	Mus musculus	28-34
29228278-2	2018	Using induced pluripotent stem cell (iPSC) models of PWS, we previously discovered an epigenetic complex that is comprised of the zinc-finger protein ZNF274 and the SET domain bifurcated 1 (SETDB1) histone H3 lysine 9 (H3K9) methyltransferase and that silences the maternal alleles at the PWS locus.	Lysine	209-215	zinc finger protein 274	Homo sapiens	150-156
29228278-2	2018	Using induced pluripotent stem cell (iPSC) models of PWS, we previously discovered an epigenetic complex that is comprised of the zinc-finger protein ZNF274 and the SET domain bifurcated 1 (SETDB1) histone H3 lysine 9 (H3K9) methyltransferase and that silences the maternal alleles at the PWS locus.	Lysine	209-215	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	190-196
28852907-1	2018	SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional repressor of inflammatory genes.	Lysine	62-68	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
29228278-2	2018	Using induced pluripotent stem cell (iPSC) models of PWS, we previously discovered an epigenetic complex that is comprised of the zinc-finger protein ZNF274 and the SET domain bifurcated 1 (SETDB1) histone H3 lysine 9 (H3K9) methyltransferase and that silences the maternal alleles at the PWS locus.	Lysine	209-215	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	165-188
29355491-12	2018	Three lysine residues (K116, K495 and K757) of hERG were predicted to be acetylated.	Lysine	6-12	ETS transcription factor ERG	Homo sapiens	47-51
29077935-9	2018	Proteomics analysis identified several nonenzymatic early (Amadori) glycations of ApoAI at lysine sites.	Lysine	91-97	apolipoprotein A1	Homo sapiens	82-87
28278764-5	2018	Using circular dichroism (CD) spectroscopy and changing the possible salt-bridging residues to new combinations of Lys, Arg, Glu, and Asp, we found that our most helical improvements came from the Arg-Glu combination, whereas the Lys-Asp was not significantly different from the Lys-Glu of the parent scaffold, PT3.	Lysine	115-118	zinc finger protein 135	Homo sapiens	311-314
29239255-7	2018	Genetic testing revealed a heterozygous transition mutation of guanine to adenine at the coding nucleotide 133 in exon 2 (c.133G&gt;A), resulting in an amino acid substitution of glutamic acid with lysine (E45K) in the MEN1 gene.	Lysine	198-204	menin 1	Homo sapiens	219-223
29355491-13	2018	Substitution of these lysine residues with arginine eliminated HDAC6 effects.	Lysine	22-28	histone deacetylase 6	Homo sapiens	63-68
29035388-2	2018	Epigenetic mechanisms are critical for transcription regulation, however, such mechanisms in the transcription regulation of HER2 are limited to the involvement of tri-methylated histone 3 lysine 4 (H3K4me3) and acetylated histone 3 lysine 9 (H3K9ac) at the HER2 promoter region.	Lysine	189-195	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
29127038-0	2018	Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids.	Lysine	0-6	NLR family pyrin domain containing 3	Homo sapiens	50-55
29127038-3	2018	Comparatively, L3C14 and L5C14 liposomes, made from the lipids bearing lysine head groups, ditetradecyl hydrophobic chains and propyl or pentyl spacers, respectively, were the most potent to activate the NLRP3 inflammasome.	Lysine	71-77	NLR family pyrin domain containing 3	Homo sapiens	204-209
29035388-2	2018	Epigenetic mechanisms are critical for transcription regulation, however, such mechanisms in the transcription regulation of HER2 are limited to the involvement of tri-methylated histone 3 lysine 4 (H3K4me3) and acetylated histone 3 lysine 9 (H3K9ac) at the HER2 promoter region.	Lysine	233-239	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
29228324-7	2018	Moreover, we found that eIF4A1, which is primarily ubiquitinated at Lys-369, is the substrate of USP9X.	Lysine	68-71	eukaryotic translation initiation factor 4A1	Homo sapiens	24-30
29404406-2	2018	Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins ASsociated with Set1) protein family that implements histone H3 lysine 4 monomethylation (H3K4me1) at enhancers, is essential for embryonic development and functions as a pancancer tumor suppressor.	Lysine	123-129	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	75-79
29362093-7	2018	A molecular dynamics analysis of the Arg376 &gt; Lys mutation based on the CYP3A4 (a human CYP450) protein structure found that it was responsible for the increase in axis length toward the heme (active site), which is critically important for biological activity and ligand binding.	Lysine	49-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
29280310-6	2018	CytoD decreases mRNA and protein levels of the Polycomb chromatin regulator Enhancer of Zeste Homolog 2 (EZH2), which controls heterochromatin formation by mediating trimethylation of histone 3 lysine 27 (H3K27me3).	Lysine	194-200	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	76-103
29280310-6	2018	CytoD decreases mRNA and protein levels of the Polycomb chromatin regulator Enhancer of Zeste Homolog 2 (EZH2), which controls heterochromatin formation by mediating trimethylation of histone 3 lysine 27 (H3K27me3).	Lysine	194-200	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	105-109
29511617-5	2018	It was determined that trimethylation of H3 histone on lysine 4 (H3K4me3) occurred in the Hif-1 transcriptional complex.	Lysine	55-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-95
29217682-5	2018	Instead, we found that G9a overexpression, and the resulting increase in histone 3 lysine 9 dimethylation (H3K9me2), increases sensitivity to cocaine reinforcement and enhances motivation for cocaine in self-administering male rats.	Lysine	83-89	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	23-26
29146594-6	2018	We found that this interaction depends on the stability lock, a structure responsible for the sustained binding between GPCRs and beta-arrestins, formed by phosphorylated serine-threonine clusters in the receptor"s C terminus and two conserved phosphate-binding lysines in the beta-arrestin2 N-domain.	Lysine	262-269	arrestin beta 2	Homo sapiens	277-291
29343685-1	2018	The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis.	Lysine	21-27	DOT1 like histone lysine methyltransferase	Homo sapiens	4-9
29212706-3	2018	In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing complex inhibits receptor-interacting Ser/Thr kinase (RIPK) activation by removing Lys-63-linked polyubiquitinated chains from key proteins in the nuclear factor kappa B (NF-kappaB) signaling pathway.	Lysine	170-173	itchy E3 ubiquitin protein ligase	Homo sapiens	59-63
29212706-3	2018	In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing complex inhibits receptor-interacting Ser/Thr kinase (RIPK) activation by removing Lys-63-linked polyubiquitinated chains from key proteins in the nuclear factor kappa B (NF-kappaB) signaling pathway.	Lysine	170-173	nuclear factor kappa B subunit 1	Homo sapiens	234-256
29212706-3	2018	In innate immunity, the itchy E3 ubiquitin protein ligase (ITCH)-A20 ubiquitin-editing complex inhibits receptor-interacting Ser/Thr kinase (RIPK) activation by removing Lys-63-linked polyubiquitinated chains from key proteins in the nuclear factor kappa B (NF-kappaB) signaling pathway.	Lysine	170-173	nuclear factor kappa B subunit 1	Homo sapiens	258-267
29233643-4	2018	Here, we report that SIRT6 deacetylates lysine 382 of p53 in short synthetic peptide sequence and in full length p53.	Lysine	40-46	tumor protein p53	Homo sapiens	113-116
29339748-1	2018	Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes.	Lysine	111-117	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
29339748-1	2018	Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes.	Lysine	111-117	DOT1 like histone lysine methyltransferase	Homo sapiens	42-47
29233643-4	2018	Here, we report that SIRT6 deacetylates lysine 382 of p53 in short synthetic peptide sequence and in full length p53.	Lysine	40-46	tumor protein p53	Homo sapiens	54-57
28925391-3	2018	Here, we show enhancer of zeste homolog 2 (EZH2), an enzyme that catalyzes H3 lysine trimethylation and associates with oncogenic function, contributes to PARPi sensitivity in breast cancer cells.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	14-41
29174981-7	2018	Excitingly, Lys-104 (K104), a previously identified lysine acetylation site of TIP60 with unknown function, was observed to be indispensable for inducing p53-mediated apoptosis under low glucose condition.	Lysine	12-15	tumor protein p53	Homo sapiens	154-157
29174981-7	2018	Excitingly, Lys-104 (K104), a previously identified lysine acetylation site of TIP60 with unknown function, was observed to be indispensable for inducing p53-mediated apoptosis under low glucose condition.	Lysine	52-58	tumor protein p53	Homo sapiens	154-157
29167269-8	2018	In addition, RNF126 overexpression consistently results in the loss of RNF168-mediated H2A monoubiquitination at lysine 13/15 and inhibition of the non-homologous end joining capability.	Lysine	113-119	ring finger protein 126	Homo sapiens	13-19
28833667-5	2018	Such DOTPI-TRAP conjugates were decorated with 3 Gly-urea-Lys (KuE) motifs for targeting prostate-specific membrane antigen (PSMA), employing Cu-catalyzed (CuAAC) as well as strain-promoted (SPAAC) click chemistry.	Lysine	58-61	folate hydrolase 1	Homo sapiens	89-123
28833667-5	2018	Such DOTPI-TRAP conjugates were decorated with 3 Gly-urea-Lys (KuE) motifs for targeting prostate-specific membrane antigen (PSMA), employing Cu-catalyzed (CuAAC) as well as strain-promoted (SPAAC) click chemistry.	Lysine	58-61	folate hydrolase 1	Homo sapiens	125-129
28925391-3	2018	Here, we show enhancer of zeste homolog 2 (EZH2), an enzyme that catalyzes H3 lysine trimethylation and associates with oncogenic function, contributes to PARPi sensitivity in breast cancer cells.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	43-47
29634390-7	2018	Furthermore, we validate that this methylation at lysine 151 impairs the binding of ATG16L1 to the ATG12-ATG5 conjugate, leading to inhibition of autophagy and increased apoptosis in H/R-treated cardiomyocytes.	Lysine	50-56	autophagy related 12	Homo sapiens	99-104
29111742-7	2018	These findings suggest that the acetylation and methylation of lysine on MBP are PTMs associated with the neurological disability produced by EAE.	Lysine	63-69	parathymosin	Mus musculus	81-85
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Lysine	178-184	advanced glycosylation end product-specific receptor	Rattus norvegicus	10-53
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Lysine	178-184	advanced glycosylation end product-specific receptor	Rattus norvegicus	55-59
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Lysine	178-184	advanced glycosylation end product-specific receptor	Rattus norvegicus	118-122
29634390-7	2018	Furthermore, we validate that this methylation at lysine 151 impairs the binding of ATG16L1 to the ATG12-ATG5 conjugate, leading to inhibition of autophagy and increased apoptosis in H/R-treated cardiomyocytes.	Lysine	50-56	autophagy related 5	Homo sapiens	105-109
29597191-9	2018	This stabilization was mediated through Lys-48 ubiquitin chains, contrary to traditionally degradative role of Lys-48 ubiquitination, suggesting that Lys-48 ubiquitination of Nrf2 protects Nrf2 from degradation thereby allowing Nrf2-dependent gene transcription.	Lysine	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
29550816-5	2018	RESULTS: We found that EphB1 was post-translationally modified by the small ubiquitin-like modifier (SUMO) protein at lysine residue 785.	Lysine	118-124	Eph receptor B1	Mus musculus	23-28
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	heat shock protein family A (Hsp70) member 5	Homo sapiens	122-127
28925507-7	2018	In RKO cells, EGCG and the EZH2 inhibitor GSK343 exhibited similar inhibitory efficacy on the proliferation, invasion and migration abilities of the cells, and suppressed protein expression of trimethylated lysine 27 on histone H3 (H3K27me3), which may be caused by the loss of the enzymatic function of EZH2.	Lysine	207-213	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	27-31
29866003-0	2018	The Effect of Single and Double Acetylation of Lysine Residues on Structural and Dynamical Features of Human Splicing Factor TDP-43 - A Statistical Ensemble Analysis.	Lysine	47-53	TAR DNA binding protein	Homo sapiens	125-131
29866003-2	2018	METHODS: Here, the consequences of TDP-43 acetylation at Lys145 within the RRM1 domain and Lys192 within the RRM2 domain were studied using experimentally verifiable molecular models, in which lysine residues (K) were substituted with glutamine (Q) as an acetylation mimic (K Q) and with arginine (R) as a non-mimic (K R) mutant.	Lysine	193-199	TAR DNA binding protein	Homo sapiens	35-41
29866003-3	2018	We used a series of computer simulations to characterize the impact of lysine acetylation on TDP-43 function and TDP-43 association with target RNA.	Lysine	71-77	TAR DNA binding protein	Homo sapiens	93-99
29567599-1	2018	Vitamin C-linker-conjugated Ala-His-Lys tripeptide (Vit C-AHK) is a derivative of Vitamin C-conjugated tripeptides, which were originally developed as a component of a product for collagen synthesis enhancement or human dermal fibroblast growth.	Lysine	36-39	vitrin	Homo sapiens	0-3
29136592-0	2018	Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair.	Lysine	48-54	sirtuin 3	Homo sapiens	6-15
29136592-0	2018	Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair.	Lysine	48-54	sirtuin 3	Homo sapiens	17-22
29136592-3	2018	Here we report interaction of SIRT3 with core histones and identified acetylated histone H3 lysine 56 (H3K56ac) as its novel substrate, in addition to known substrates acetylated H4K16 and H3K9.	Lysine	92-98	sirtuin 3	Homo sapiens	30-35
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	Lysine	102-108	MLLT3 super elongation complex subunit	Homo sapiens	44-47
29503861-0	2018	Synthesis of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform.	Lysine	48-51	nuclear receptor subfamily 0 group B member 1	Homo sapiens	52-55
29503861-0	2018	Synthesis of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform.	Lysine	48-51	folate hydrolase 1	Homo sapiens	65-69
29503861-9	2018	The aim of this work was to optimize the labeling of [18F]AlF-[GLU-UREA-LYS(AHX)-HBED-CC] in a Tracerlab FXFN  (GE) platform.	Lysine	72-75	nuclear receptor subfamily 0 group B member 1	Homo sapiens	76-79
29095570-6	2018	Together with previous results, this structure suggests a common proton relay network shared by Class A beta-lactamases and PBPs, from the catalytic serine to the lysine, and ultimately to the ring nitrogen.	Lysine	163-169	amyloid beta precursor protein	Homo sapiens	102-108
29143452-3	2018	However, the pathogen produces secreted aspartic proteases (Saps) that cleave Hst-5 at lysine residues and eliminate its antifungal properties.	Lysine	87-93	histatin 3	Homo sapiens	78-83
29143452-4	2018	We designed variants of Hst-5 with its lysine residues substituted with arginine or leucine to evaluate the effect on proteolysis by Saps.	Lysine	39-45	histatin 3	Homo sapiens	24-29
29115470-2	2018	Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone-lysine N-methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing.	Lysine	27-33	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	61-109
29179065-1	2018	The major function of the enzyme human tissue transglutaminase (TG2) is the crosslinking of proteins via a transamidation between the gamma-carboxamide of a glutamine and the epsilon-amino group of a lysine.	Lysine	200-206	transglutaminase 2	Homo sapiens	39-62
29115470-2	2018	Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone-lysine N-methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing.	Lysine	27-33	euchromatic histone lysine methyltransferase 2	Rattus norvegicus	111-114
29190078-2	2017	The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively).	Lysine	55-58	albumin	Homo sapiens	100-113
29482435-5	2018	We have recently reported that the methyltransferase MMSET catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2) at the lesion site.	Lysine	104-110	nuclear receptor binding SET domain protein 2	Homo sapiens	53-58
29311809-3	2017	Our previous work has shown that transcriptional activation of c-Fos and Egr-1 in the hippocampus requires formation of a dual histone mark within their promoter regions, the phosphorylation of serine 10 and acetylation of lysine 9/14 of histone H3.	Lysine	223-229	early growth response 1	Rattus norvegicus	73-78
29281621-3	2017	In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitination at lysine 164 promotes recruitment of TLS polymerases, allowing cells to efficiently cope with DNA damage.	Lysine	63-69	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	25-30
29263300-7	2017	Site-directed mutagenesis revealed that ubiquitination of specific PDGFR-alpha lysine residues was responsible for its autophagic degradation.	Lysine	79-85	platelet derived growth factor receptor alpha	Homo sapiens	67-78
29337674-5	2017	Moreover, the molecular docking study of xyloketal A with activation region of the stromal interaction molecule (STIM) 1 and the calcium release-activated calcium modulator (ORAI) 1 (STIM1-ORAI1) protein complex, the key domain of SOCE, revealed that xyloketal A exhibited a noncovalent interaction with the key residue lysine 363 (LYS363) in the identified cytosolic regions in STIM1-C.	Lysine	320-326	stromal interaction molecule 1	Mus musculus	83-120
29337674-5	2017	Moreover, the molecular docking study of xyloketal A with activation region of the stromal interaction molecule (STIM) 1 and the calcium release-activated calcium modulator (ORAI) 1 (STIM1-ORAI1) protein complex, the key domain of SOCE, revealed that xyloketal A exhibited a noncovalent interaction with the key residue lysine 363 (LYS363) in the identified cytosolic regions in STIM1-C.	Lysine	320-326	stromal interaction molecule 1	Mus musculus	183-188
29435148-5	2018	We designed a 15 amino acids peptide based on the sequence of the RelA protein (residues 302-316), containing the lysine that is methylated by SETD6.	Lysine	114-120	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	143-148
29092815-8	2017	We conclude that serine 173, which is equivalent to lysine 166 in the activation loop of human Chk1, is only critical in DNA polymerase mutants or when forks collapse in the absence of Cds1.	Lysine	52-58	checkpoint kinase 1	Homo sapiens	95-99
29234079-6	2017	Of the candidates, we found Atac2, a histone acetyltransferase, was SUMOylated at a lysine 408, and further modified by multiple SUMOs without isoform specificity.	Lysine	84-90	lysine acetyltransferase 14	Homo sapiens	28-33
29416751-8	2018	TSA acetylated HIF-1alpha at lysine (K) 674, which led to an increase in TSA-induced VEGF-HRE reporter activity.	Lysine	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
29416751-8	2018	TSA acetylated HIF-1alpha at lysine (K) 674, which led to an increase in TSA-induced VEGF-HRE reporter activity.	Lysine	29-35	vascular endothelial growth factor A	Homo sapiens	85-89
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	24-30	SMAD family member 7	Homo sapiens	66-71
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	24-30	SMAD family member 7	Homo sapiens	102-107
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	72-78	SMAD family member 7	Homo sapiens	66-71
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	72-78	SMAD family member 7	Homo sapiens	102-107
29054408-3	2017	Here, we show HDAC6 negatively regulates pro-apoptotic acetylation of p53 at lysine residue 120 (K120) in mesenchymal stem cells (MSCs).	Lysine	77-83	histone deacetylase 6	Homo sapiens	14-19
29054408-3	2017	Here, we show HDAC6 negatively regulates pro-apoptotic acetylation of p53 at lysine residue 120 (K120) in mesenchymal stem cells (MSCs).	Lysine	77-83	tumor protein p53	Homo sapiens	70-73
29030430-6	2017	Several surface-exposed Lys residues are present in IL-1beta, but not in IL1RN.	Lysine	24-27	interleukin 1 beta	Homo sapiens	52-60
29030430-8	2017	Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.	Lysine	20-23	interleukin 1 beta	Homo sapiens	83-91
29030430-8	2017	Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, suggesting that the Lys residues mediate integrin binding.	Lysine	113-116	interleukin 1 beta	Homo sapiens	83-91
29153392-1	2017	Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development.	Lysine	67-73	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	36-40
29055779-7	2017	We could show that UHRF1 ubiquitinates PAF15 at Lys 15 and Lys 24 and promotes its binding to PCNA during late S-phase.	Lysine	48-51	PCNA clamp associated factor	Mus musculus	39-44
28945012-6	2017	The present work shows that thousands of polyethylene glycol (PEG) chains modified with lysines and functionalized with GE11 on clusters of naked gold nanoparticles, obtained by laser ablation in water, achieves a better targeting activity than that recorded with nanoparticles decorated with the specific anti-EGFR antibody Cetuximab (C225).	Lysine	88-95	epidermal growth factor receptor	Homo sapiens	311-315
29220657-2	2017	Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2.	Lysine	99-105	polycomb group ring finger 3	Homo sapiens	41-46
29107034-6	2017	Furthermore, we found that AtMBP-1 is lysine-acetylated and vulnerable to proteasomal protein degradation, while AtSRT1 could remove its lysine acetylation and significantly enhance its stability in vivo.	Lysine	38-44	myrosinase-binding protein 1	Arabidopsis thaliana	27-34
29107034-6	2017	Furthermore, we found that AtMBP-1 is lysine-acetylated and vulnerable to proteasomal protein degradation, while AtSRT1 could remove its lysine acetylation and significantly enhance its stability in vivo.	Lysine	137-143	sirtuin 1	Arabidopsis thaliana	113-119
28986444-6	2017	Our efforts revealed that lys encodes the Drosophila homolog of Lysine Ketoglutarate Reductase/Saccharopine Dehydrogenase, which is required for the enzymatic degradation of lysine.	Lysine	26-29	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	64-121
28950199-2	2017	Currently, it mainly features Gallium-68 (68Ga) labeled PSMA ligands, notably [68Ga]Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-11) and [68Ga]DOTAGA-FFK (Sub-KuE termed ([68Ga]PSMA-I&amp;T).	Lysine	93-96	folate hydrolase 1	Homo sapiens	56-60
28950199-5	2017	Here, we describe a simple synthesis and validation of a fluorine-18 labeled Glu-urea-Lys(Ahx)-HBED-CC ([Al18F]PSMA-11) for nuclear medicine applications.	Lysine	86-89	folate hydrolase 1	Homo sapiens	111-115
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	DOT1 like histone lysine methyltransferase	Homo sapiens	98-103
29079528-5	2017	Six early lysine (Amadori) and one advanced arginine glycation were detected in Trf.	Lysine	10-16	telomeric repeat binding factor 1	Homo sapiens	80-83
28986444-6	2017	Our efforts revealed that lys encodes the Drosophila homolog of Lysine Ketoglutarate Reductase/Saccharopine Dehydrogenase, which is required for the enzymatic degradation of lysine.	Lysine	174-180	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	64-121
29261844-3	2017	Enhancer of Zeste homolog 2 (Ezh2), which catalyzes dimethylation/trimethylation of histone 3 lysine 27 (H3K27me2 and me3), is also associated with DNA methylation.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
28283455-0	2017	Synthesis of water-dispersible poly-l-lysine-functionalized magnetic Fe3O4-(GO-MWCNTs) nanocomposite hybrid with a large surface area for high-efficiency removal of tartrazine and Pb(II).	Lysine	31-44	submaxillary gland androgen regulated protein 3B	Homo sapiens	180-186
29261844-3	2017	Enhancer of Zeste homolog 2 (Ezh2), which catalyzes dimethylation/trimethylation of histone 3 lysine 27 (H3K27me2 and me3), is also associated with DNA methylation.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29127861-0	2017	Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome.	Lysine	76-82	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	8-12
28974580-4	2017	Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5.	Lysine	35-41	SUMO specific peptidase 1	Homo sapiens	122-168
28732179-6	2017	However, HYD-1 (Lys-Ile-Lys-Met-Val-Ile-Ser-Trp-Lys-Gly), an integrin antagonist, inhibited the KGF-enhanced epithelial adhesion and rete peg elongation.	Lysine	16-19	fibroblast growth factor 7	Homo sapiens	96-99
28732179-6	2017	However, HYD-1 (Lys-Ile-Lys-Met-Val-Ile-Ser-Trp-Lys-Gly), an integrin antagonist, inhibited the KGF-enhanced epithelial adhesion and rete peg elongation.	Lysine	24-27	fibroblast growth factor 7	Homo sapiens	96-99
29038915-0	2017	Glycation of Lys-16 and Arg-5 in amyloid-beta and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer"s disease.	Lysine	13-16	amyloid beta precursor protein	Homo sapiens	33-45
29038915-4	2017	Mass spectral (MS) analysis of the reactions of Abeta with two representative sugars, ribose-5-phosphate (R5P) and methylglyoxal (MG), revealed Lys-16 and Arg-5 as the primary glycation sites.	Lysine	144-147	amyloid beta precursor protein	Homo sapiens	48-53
28485501-3	2017	The expression of HDAC1 increased and acetylation of histone H3 at lysine 9 (H3K9ac) decreased in the aorta of ApoE-/- mice fed with high methionine diet, whereas miR-34a expression was inhibited.	Lysine	67-73	apolipoprotein E	Mus musculus	111-115
29069627-3	2017	Here, we report that the Src protein can be SUMOylated at lysine 318 both in vitro and in vivo.	Lysine	58-64	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-28
28639122-7	2017	RESULTS: F-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with [18F]SFB and (2) oxime formation with 4-[18F]fluorobenzaldehyde and [18F]FDG using the respective aminooxy-functionalized lysine residue.	Lysine	150-156	folate hydrolase 1	Homo sapiens	22-26
28639122-7	2017	RESULTS: F-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with [18F]SFB and (2) oxime formation with 4-[18F]fluorobenzaldehyde and [18F]FDG using the respective aminooxy-functionalized lysine residue.	Lysine	292-298	folate hydrolase 1	Homo sapiens	22-26
28663172-6	2017	Recombinant METTL21B was shown in vitro to catalyze methylation on lysine 165 in eEF1A1 and eEF1A2, confirming it as the methyltransferase responsible for this methylation site.	Lysine	67-73	EEF1A lysine methyltransferase 3	Homo sapiens	12-20
28663172-8	2017	METTL21B exists only in vertebrates, with its target lysine showing similar evolutionary conservation.	Lysine	53-59	EEF1A lysine methyltransferase 3	Homo sapiens	0-8
29069627-8	2017	Our results suggest that SUMOylation of Src at lysine 318 negatively modulate its oncogenic function by, at least partially, inhibiting Src-FAK complex activity.	Lysine	47-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-43
29069627-8	2017	Our results suggest that SUMOylation of Src at lysine 318 negatively modulate its oncogenic function by, at least partially, inhibiting Src-FAK complex activity.	Lysine	47-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	136-139
29180628-6	2017	We further identify lysine 477 (K477) of HIF-1alpha as a major ubiquitination site for Parkin.	Lysine	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
29190800-2	2017	Recent work has shown that the Estrogen-Related Receptor alpha (ERRalpha) induces LSD1 to demethylate the Lys 9 of histone H3.	Lysine	106-109	estrogen related receptor alpha	Homo sapiens	31-62
29190800-2	2017	Recent work has shown that the Estrogen-Related Receptor alpha (ERRalpha) induces LSD1 to demethylate the Lys 9 of histone H3.	Lysine	106-109	estrogen related receptor alpha	Homo sapiens	64-72
28759046-5	2017	Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions.	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	81-85
28974578-1	2017	The acylation of lysine residues in superoxide dismutase-1 (SOD1) has been previously shown to decrease its rate of nucleation and elongation into amyloid-like fibrils linked to amyotrophic lateral sclerosis.	Lysine	17-23	superoxide dismutase 1, soluble	Mus musculus	60-64
28974578-4	2017	Here, we acylated a fraction of lysine residues in SOD1 with groups of variable hydrophobicity, charge, and conformational entropy.	Lysine	32-38	superoxide dismutase 1, soluble	Mus musculus	51-55
28974578-6	2017	The effect of the lysine acylation on the prion-like seeding of SOD1 was assayed in spinal cord extracts of transgenic mice expressing a G85R SOD1-yellow fluorescent protein construct.	Lysine	18-24	superoxide dismutase 1, soluble	Mus musculus	64-68
29129908-2	2017	Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis.	Lysine	70-76	epidermal growth factor receptor	Homo sapiens	204-208
29119993-7	2017	We have also obtained a crystal structure depicting covalent modification of the catalytic lysine of a tyrosine kinase (FGFR1) by the ATP analog 5"-O-3-((fluorosulfonyl)benzoyl)adenosine (m-FSBA).	Lysine	91-97	fibroblast growth factor receptor 1	Homo sapiens	120-125
28912266-0	2017	Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.	Lysine	0-6	heat shock protein family A (Hsp70) member 5	Homo sapiens	32-64
28912266-5	2017	ER stress leads to de novo biosynthesis of non-trimethylated GRP78, whereas homeostatic, METTL21A-dependent lysine 585-trimethylated GRP78 is reduced.	Lysine	108-114	heat shock protein family A (Hsp70) member 5	Homo sapiens	133-138
29021135-5	2017	Mechanistic investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate PIK3CA transcription, thereby enhancing PI3K/AKT signaling and tumorigenesis.	Lysine	62-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	166-172
29021135-5	2017	Mechanistic investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate PIK3CA transcription, thereby enhancing PI3K/AKT signaling and tumorigenesis.	Lysine	62-68	AKT serine/threonine kinase 1	Homo sapiens	211-214
28947430-13	2017	SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of LKB1-AMPK signaling.	Lysine	43-49	serine/threonine kinase 11	Mus musculus	15-19
28947430-13	2017	SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of LKB1-AMPK signaling.	Lysine	43-49	serine/threonine kinase 11	Mus musculus	92-96
28947430-13	2017	SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of LKB1-AMPK signaling.	Lysine	43-49	serine/threonine kinase 11	Mus musculus	92-96
29270451-1	2018	In association with the published article "Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy" (Huang et al., 2017) [1], this data article contains information about deSUMOylation of HSF2 on lysine 82 on angiotensin II (ANG II) -induced cardiac hypertrophy, which is mediated by MEL18.	Lysine	255-261	heat shock transcription factor 2	Homo sapiens	57-61
29270451-1	2018	In association with the published article "Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy" (Huang et al., 2017) [1], this data article contains information about deSUMOylation of HSF2 on lysine 82 on angiotensin II (ANG II) -induced cardiac hypertrophy, which is mediated by MEL18.	Lysine	255-261	polycomb group ring finger 2	Homo sapiens	78-83
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	176-182	deoxyhypusine synthase	Homo sapiens	0-22
29127375-5	2017	We show that UV-dependent histone H1 ubiquitylation at multiple lysines is mediated by the E3-ligase HUWE1.	Lysine	64-71	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	101-106
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	233-240	deoxyhypusine synthase	Homo sapiens	0-22
28784321-9	2017	These results provide evidence that only the simultaneous absence of YHM2, ODC1 and ODC2 impairs the export from the mitochondrial matrix of i) 2-oxoglutarate which is necessary for the synthesis of glutamate and ammonium fixation in the cytosol and ii) 2-oxoadipate which is required for lysine biosynthesis in the cytosol.	Lysine	289-295	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	75-79
28765327-5	2017	In a validation step, 10 paired bladder cancer and normal tissues, different tumor cell lines, the public microarray datasets of human bladder cancer, and The Cancer Genome Atlas database were applied for the verification of gene expression.Results: KMT1A was highly expressed and responsible for the increase of tri-methylating lysine 9 of histone H3 (H3K9me3) modification in BCSCs compared with either BCNSCs or normal bladder tissue.	Lysine	329-335	SUV39H1 histone lysine methyltransferase	Homo sapiens	250-255
28470351-8	2017	The synthetic octapeptide of CCK (CCK-8) could accelerate the lysine acetylation of a subset of proteins in dose-dependent manners in GBC-SD cells.	Lysine	62-68	cholecystokinin	Homo sapiens	29-32
28470351-8	2017	The synthetic octapeptide of CCK (CCK-8) could accelerate the lysine acetylation of a subset of proteins in dose-dependent manners in GBC-SD cells.	Lysine	62-68	cholecystokinin	Homo sapiens	34-39
28470351-11	2017	CONCLUSIONS: CCK might regulate protein lysine acetylation via CCK1 receptor.	Lysine	40-46	cholecystokinin	Homo sapiens	13-16
28722259-0	2017	l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.	Lysine	16-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-105
28722259-5	2017	Moreover, the stimulatory effect of Orn and Lys was abolished in TRPV1-knockout mice.	Lysine	44-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
28722259-7	2017	These results suggest that Orn and Lys promote GI motility via activation of TRPV1.	Lysine	35-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	77-82
28722259-9	2017	CONCLUSION: Orally administered Orn and Lys stimulate GI motility via TRPV1, mAChR and NO synthase in mice.	Lysine	40-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	70-75
29045069-4	2017	Imputation was used to identify associations at HLA-C Asn80Lys (Asn, C1; Lys, C2) and KIR.	Lysine	59-62	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	86-89
28765174-5	2017	In addition, TERRA participated in telomeric chromatin remodeling by cooperating with SUV39H1 (suppressor of variegation 3-9 homolog 1/2) to propagate telomeric heterochromatin marker, histone H3 trimethylation of lysine 9.	Lysine	214-220	SUV39H1 histone lysine methyltransferase	Homo sapiens	86-136
28748258-4	2017	Enhancer of zeste Homolog 2 (EZH2) is the catalytic subunit of PRC2, which catalyzes methylation of lysine 27 of histone H3 (H3K27).	Lysine	100-106	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
28748258-4	2017	Enhancer of zeste Homolog 2 (EZH2) is the catalytic subunit of PRC2, which catalyzes methylation of lysine 27 of histone H3 (H3K27).	Lysine	100-106	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27815838-3	2017	This purpose of the study focused on exploring whether epigenetic modifications marker histone H3 lysine 27 trimethylation (H3K27me3)-regulated DPP4 and IL6 expression further affected seizures development.	Lysine	98-104	interleukin 6	Rattus norvegicus	153-156
28841445-0	2017	APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization.	Lysine	9-15	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	0-8
29113254-11	2017	FHL1 was synergistically silenced by DNA methylation and histone modification, and 3-deanzaneplanocin A (DZNep), an inhibitor of EZH2, which is a histone methyltransferase of the polycomb repressive complex 2, which catalyzes histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	237-243	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	129-133
28766141-9	2017	The paradoxical decrease of the slope factor of the steady-state inactivation and acceleration of inactivation kinetics upon charge neutralization in segment IS4 may reflect the loss of stabilizing interactions of arginines and lysine with surrounding residues.	Lysine	228-234	IS4	Homo sapiens	158-161
29107294-8	2017	Antagonists of mGluR4 greatly reduced the responses to alanine and lysine.	Lysine	67-73	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	15-21
28841445-4	2017	Here we ask whether lysines and/or lysine post-translational modifications are required for these A3B activities.	Lysine	20-27	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	98-101
28841445-4	2017	Here we ask whether lysines and/or lysine post-translational modifications are required for these A3B activities.	Lysine	20-26	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	98-101
28841445-5	2017	A lysine-free derivative of human A3B was constructed and shown to be indistinguishable from the wild-type enzyme in DNA cytosine deamination, HIV-1 restriction, and nuclear localization activities.	Lysine	2-8	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	34-37
28887308-0	2017	Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.	Lysine	132-138	citrate synthase lysine methyltransferase	Homo sapiens	17-24
29268844-6	2017	Chromatin immunoprecipitation (ChIP) was done to evaluate the effect of KAT6B on the recruitment of acetylation of histone 3 lysine 23 (H3K23ac) within IL-6 promoter region.	Lysine	125-131	interleukin 6	Mus musculus	152-156
29416718-0	2018	ING5 differentially regulates protein lysine acetylation and promotes p300 autoacetylation.	Lysine	38-44	inhibitor of growth family member 5	Homo sapiens	0-4
29416718-5	2018	Here, we have found that ING5 has a profound influence on protein lysine acetylation with 163 acetylation peptides on 122 proteins significantly upregulated and 100 acetylation peptides on 72 proteins downregulated by ING5 overexpression.	Lysine	66-72	inhibitor of growth family member 5	Homo sapiens	25-29
29520394-0	2017	Development and Validation of a High-Pressure Liquid Chromatography Method for the Determination of Chemical Purity and Radiochemical Purity of a [68Ga]-Labeled Glu-Urea-Lys(Ahx)-HBED-CC (Positron Emission Tomography) Tracer.	Lysine	170-173	nuclear receptor subfamily 0 group B member 1	Homo sapiens	174-177
29520394-2	2017	[68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer.	Lysine	24-27	nuclear receptor subfamily 0 group B member 1	Homo sapiens	28-31
29520394-2	2017	[68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer.	Lysine	24-27	folate hydrolase 1	Homo sapiens	49-53
29520394-2	2017	[68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer.	Lysine	24-27	folate hydrolase 1	Homo sapiens	74-78
28887308-4	2017	Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site.	Lysine	93-96	citrate synthase lysine methyltransferase	Homo sapiens	68-75
29068315-6	2017	Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2.	Lysine	72-78	ring finger protein 145	Mus musculus	30-36
28837921-2	2017	The BAZ2A bromodomain is a challenging target because of the shallow pocket of its natural ligand, the acetylated side chain of lysine.	Lysine	128-134	bromodomain adjacent to zinc finger domain 2A	Homo sapiens	4-9
28892616-4	2017	Upon identifying a lead hit from this screen KEA1-97, we used activity-based protein profiling (ABPP)-based chemoproteomic platforms to identify that this compound targets lysine 72 of thioredoxin-a site previously shown to be important in protein interactions with caspase 3 to inhibit caspase 3 activity and suppress apoptosis.	Lysine	172-178	amyloid beta precursor protein	Homo sapiens	96-100
28892616-4	2017	Upon identifying a lead hit from this screen KEA1-97, we used activity-based protein profiling (ABPP)-based chemoproteomic platforms to identify that this compound targets lysine 72 of thioredoxin-a site previously shown to be important in protein interactions with caspase 3 to inhibit caspase 3 activity and suppress apoptosis.	Lysine	172-178	caspase 3	Homo sapiens	266-275
28892616-4	2017	Upon identifying a lead hit from this screen KEA1-97, we used activity-based protein profiling (ABPP)-based chemoproteomic platforms to identify that this compound targets lysine 72 of thioredoxin-a site previously shown to be important in protein interactions with caspase 3 to inhibit caspase 3 activity and suppress apoptosis.	Lysine	172-178	caspase 3	Homo sapiens	287-296
28929747-5	2017	Lysine methylation was used to obtain the crystal structure of Cqestbeta21, which adopts a canonical alpha/beta-hydrolase fold that has high similarity to the target of organophosphate and carbamate insecticides, acetylcholinesterase.	Lysine	0-6	acetylcholinesterase	Culex quinquefasciatus	213-233
29045477-2	2017	Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-beta1-induced EMT (epithelial-mesenchymal transition).	Lysine	96-102	histone deacetylase 6	Mus musculus	0-21
29045477-2	2017	Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-beta1-induced EMT (epithelial-mesenchymal transition).	Lysine	96-102	histone deacetylase 6	Mus musculus	23-28
28958848-4	2017	As predicted based on SIRT6 biological roles, the new leads increase histone 3 lysine 9 acetylation and glucose uptake in cultured cells, while blocking TNF-alpha production and T lymphocyte proliferation.	Lysine	79-85	tumor necrosis factor	Homo sapiens	153-162
29035199-4	2017	Structures reveal the unique feature of Kap123 that possesses two discrete lysine-binding pockets for NLS recognition.	Lysine	75-81	Kap123p	Saccharomyces cerevisiae S288C	40-46
29035199-6	2017	Additionally, acetylation of key lysine residues at NLS, particularly H4-NLS diacetylation, weakens the interaction with Kap123.	Lysine	33-39	Kap123p	Saccharomyces cerevisiae S288C	121-127
28864775-1	2017	Lysyl oxidase-like-2 (LOXL2) is an enzyme secreted into the extracellular matrix that crosslinks collagens by mediating oxidative deamination of lysine residues.	Lysine	145-151	lysyl oxidase like 2	Homo sapiens	0-20
28864775-1	2017	Lysyl oxidase-like-2 (LOXL2) is an enzyme secreted into the extracellular matrix that crosslinks collagens by mediating oxidative deamination of lysine residues.	Lysine	145-151	lysyl oxidase like 2	Homo sapiens	22-27
28968467-1	2017	Expression of E7 proteins encoded by carcinogenic, high-risk human papillomaviruses (HPVs) triggers increased expression of the histone H3 lysine 27 demethylase KDM6A.	Lysine	139-145	lysine demethylase 6A	Homo sapiens	161-166
28581524-5	2017	Also, we discover that Smurf1 directly binds to the kinase domain of PIPKIgamma via its C2 domain while Lysine 255 in PIPKIgamma acts as the major ubiquitin acceptor site for Smurf1.	Lysine	104-110	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	175-181
29020630-6	2017	Lysine 17 in Bcl-2 serves as the main acceptor for ubiquitylation, and a Bcl-2 K17A mutant has increased stability and is more potent in protection against apoptosis.	Lysine	0-6	BCL2 apoptosis regulator	Homo sapiens	13-18
28899943-5	2017	Results presented here indicate that Isw1 is not only ubiquitylated but also strongly SUMOylated on multiple lysine residues by the redundant Siz1/Siz2 SUMO E3 ligases.	Lysine	109-115	chromatin-remodeling ATPase ISW1	Saccharomyces cerevisiae S288C	37-41
28872461-6	2017	Mechanistic studies revealed that trihydroxyphenolics induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI kinase.	Lysine	98-104	lysyl oxidase like 2	Homo sapiens	81-86
28872461-6	2017	Mechanistic studies revealed that trihydroxyphenolics induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI kinase.	Lysine	98-104	lysyl oxidase like 2	Homo sapiens	168-173
28890329-3	2017	Methyltransferase SETDB1 (Set domain, bifurcated 1) catalyzes histone H3 lysine 9 (H3K9) trimethylation and represses gene expression.	Lysine	73-79	SET domain, bifurcated 1	Mus musculus	18-24
28804911-7	2017	RESULTS: We found that EtOH metabolism significantly increased the acetylation of SOD2 at 2 functionally relevant lysine sites, K68 and K122, resulting in a 40% decrease in enzyme activity while overall SOD2 abundance was unchanged.	Lysine	114-120	superoxide dismutase 2, mitochondrial	Mus musculus	82-86
28804911-10	2017	CONCLUSIONS: Overall, the findings presented in this study support a role for EtOH-induced lysine acetylation as an adverse posttranslational modification within the mitochondria that directly impacts SOD2 charge state and activity.	Lysine	91-97	superoxide dismutase 2, mitochondrial	Mus musculus	201-205
28923203-6	2017	Our further studies show that down-regulation of miR-34a is caused by Enhancer of zeste homolog 2 (EZH2)-mediated H3 lysine 27 trimethylation as well as DNA methylation.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	70-97
28923203-6	2017	Our further studies show that down-regulation of miR-34a is caused by Enhancer of zeste homolog 2 (EZH2)-mediated H3 lysine 27 trimethylation as well as DNA methylation.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	99-103
28899795-2	2017	In this study, we investigated the expression, function and cross-association of microRNA-137-3p (miR-137-3p) and lysine (K)-specific demethylase 1A (LSD1) in a murine model of Bv-induced neural injury in DRGNs.	Lysine	114-120	lysine (K)-specific demethylase 1A	Mus musculus	150-154
28892081-2	2017	Here we show that A20 monoubiquitylates Snail1 at three lysine residues and thereby promotes metastasis of aggressive basal-like breast cancers.	Lysine	56-62	snail family transcriptional repressor 1	Homo sapiens	40-46
28819043-3	2017	In our previous study, we showed that inhibition of histone deacetylase 6 (HDAC6), which deacetylates tubulin at lysine 40, rescues defects in MTs and in neuromuscular junction growth caused by tau overexpression.	Lysine	113-119	histone deacetylase 6	Homo sapiens	52-73
28819043-3	2017	In our previous study, we showed that inhibition of histone deacetylase 6 (HDAC6), which deacetylates tubulin at lysine 40, rescues defects in MTs and in neuromuscular junction growth caused by tau overexpression.	Lysine	113-119	histone deacetylase 6	Homo sapiens	75-80
28612962-6	2017	Viral-mediated miR-101a-3p overexpression also reduced expression of the histone methyltransferase Ezh2, which mediates gene silencing via trimethylation of histone 3 at lysine 27 (H3K27me3).	Lysine	170-176	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	99-103
28879500-1	2017	ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3).	Lysine	100-106	ETS transcription factor ERG	Homo sapiens	0-3
28879500-1	2017	ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3).	Lysine	100-106	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	44-48
28879500-1	2017	ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3).	Lysine	100-106	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	73-79
28879500-1	2017	ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3).	Lysine	100-106	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	80-85
28666590-4	2017	For example, TLS is mediated by mono-ubiquitination of PCNA at lysine 164, for which RAD6-RAD18 is the primary E2-E3 complex.	Lysine	63-69	FUS RNA binding protein	Homo sapiens	13-16
28669410-2	2017	Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from partially degraded fibrin, and anti-inflammatory, by downregulating complement anaphylatoxins C3a and C5a.	Lysine	192-198	coagulation factor II, thrombin	Homo sapiens	65-73
28947800-3	2017	Here, we show that malfunctioned cytosolic acetyl-CoA carboxylase1 (ACC1) in Arabidopsis leads to elevated levels of acetyl-CoA and promotes histone hyperacetylation predominantly at lysine 27 of histone H3 (H3K27).	Lysine	183-189	acetyl-CoA carboxylase 1	Arabidopsis thaliana	43-66
28947800-3	2017	Here, we show that malfunctioned cytosolic acetyl-CoA carboxylase1 (ACC1) in Arabidopsis leads to elevated levels of acetyl-CoA and promotes histone hyperacetylation predominantly at lysine 27 of histone H3 (H3K27).	Lysine	183-189	acetyl-CoA carboxylase 1	Arabidopsis thaliana	68-72
28669410-2	2017	Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from partially degraded fibrin, and anti-inflammatory, by downregulating complement anaphylatoxins C3a and C5a.	Lysine	192-198	complement C5a receptor 1	Homo sapiens	315-318
28534516-6	2017	HOTTIP directly bound the adaptor protein WDR5 and drove histone H3 lysine 4 trimethylation and HOXA13 gene transcription in ESCC cells.	Lysine	68-74	WD repeat domain 5	Homo sapiens	42-46
28794155-4	2017	Luciferase reporter assay, quantitative PCR, and Western blotting demonstrated that miR-125b directly binds the 3"-untranslated region of SUV39H1, encoding the histone-lysine N-methyltransferase SUV39H1, to down-regulate histone H3 lysine-9 tri-methylation (H3K9me3) in SCNT embryos.	Lysine	168-174	SUV39H1 histone lysine methyltransferase	Homo sapiens	138-145
28534506-4	2017	LSD1 demethylates HIF1alpha at lysine (K) 391, which protects HIF1alpha against ubiquitin-mediated protein degradation.	Lysine	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-27
28534506-4	2017	LSD1 demethylates HIF1alpha at lysine (K) 391, which protects HIF1alpha against ubiquitin-mediated protein degradation.	Lysine	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-71
29228694-1	2017	Enhancer of zeste homolog 2 (EZH2) is the catalytic unit of polycomb repressive complex 2 (PRC2) which epigenetically silences many genes involved in tumor-suppressive mechanisms via the trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	205-211	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
29228694-1	2017	Enhancer of zeste homolog 2 (EZH2) is the catalytic unit of polycomb repressive complex 2 (PRC2) which epigenetically silences many genes involved in tumor-suppressive mechanisms via the trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	205-211	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
28928432-6	2017	Single mutants in MDH3 or GPD1 grow on lysine-deficient medium, but an mdh3/gpd1Delta double mutant accumulates saccharopine and displays lysine bradytrophy.	Lysine	39-45	malate dehydrogenase MDH3	Saccharomyces cerevisiae S288C	18-22
28928432-6	2017	Single mutants in MDH3 or GPD1 grow on lysine-deficient medium, but an mdh3/gpd1Delta double mutant accumulates saccharopine and displays lysine bradytrophy.	Lysine	138-144	malate dehydrogenase MDH3	Saccharomyces cerevisiae S288C	71-75
28928432-7	2017	Lysine biosynthesis is restored when saccharopine dehydrogenase is mislocalised to the cytosol in mdh3/gpd1Delta cells.	Lysine	0-6	malate dehydrogenase MDH3	Saccharomyces cerevisiae S288C	98-102
28794503-2	2017	In trained immunity, increased cytokine levels of genes, like interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha, are observed, which are associated with increased histone 3 lysine 4 trimethylation (H3K4me3) in the promoter region.	Lysine	180-186	tumor necrosis factor	Homo sapiens	85-118
28853470-3	2017	We demonstrated that functional N-phenylvinylsulfonamide derivatives with a fluorescent moiety or drug could also be conjugated to the lysine residue of octreotide and insulin with high specificity, without modifying the N-terminus.	Lysine	135-141	insulin	Homo sapiens	168-175
28883613-6	2017	To mimic inflammation during atherogenesis, human myeloperoxidase was incubated with glycine, H2O2, malondialdehyde, and a lysine analog in PBS at a physiological temperature, which resulted in M2FA generation.	Lysine	123-129	myeloperoxidase	Homo sapiens	50-65
28877217-4	2017	Mutagenic replacement of Arg-878 with an alanine or a lysine residue decreased the affinity of the recombinant enzymes for the acidic substrate, alpha-L-glutamyl-beta-naphthylamide, with a slight decrease in substrate hydrolysis velocity either with or without Ca2+.	Lysine	54-60	carbonic anhydrase 2	Mus musculus	261-264
28877467-3	2017	Here, using a combination of live-cell imaging and functional genomics, we discover that the vertebrate SET1 complex is targeted to actively transcribed gene promoters through CFP1, which engages in a form of multivalent chromatin reading that involves recognition of non-methylated DNA and histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	302-308	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	104-108
28698146-2	2017	KDM6A is a candidate tumor suppressor gene that encodes a histone H3 lysine 27 (H3K27) demethylase.	Lysine	69-75	lysine demethylase 6A	Homo sapiens	0-5
28687409-8	2017	Furthermore, the deacetylase effect of Sirt3 enhanced the MnSOD activity by deacetylation at the lysine 68 residue and therapeutic effect of UCB-MSCs on skin-wound healing was increased by EphB2 activation.	Lysine	97-103	sirtuin 3	Homo sapiens	39-44
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	20-26	malic enzyme 3, NADP(+)-dependent, mitochondrial	Mus musculus	141-153
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	87-93	malic enzyme 3, NADP(+)-dependent, mitochondrial	Mus musculus	141-153
28720663-4	2017	Lysine-84 of Stv1NT is essential for interaction with PI(4)P in vitro and in vivo, and interaction with PI(4)P is required for efficient localization of Stv1-containing V-ATPases.	Lysine	0-6	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	13-17
28878842-2	2017	The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for the trimethylation at lysine 27 of histone 3 (H3K27me3), is associated with a poor clinical prognosis and aggressive HPV-positive phenotypes.	Lysine	124-130	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-49
28878842-2	2017	The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for the trimethylation at lysine 27 of histone 3 (H3K27me3), is associated with a poor clinical prognosis and aggressive HPV-positive phenotypes.	Lysine	124-130	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	51-55
28878246-4	2017	NR2E3 loss promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR expression.	Lysine	80-86	lysine (K)-specific demethylase 1A	Mus musculus	39-43
28878246-4	2017	NR2E3 loss promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR expression.	Lysine	80-86	aryl-hydrocarbon receptor	Mus musculus	122-125
28647331-0	2017	Combination of histidine, lysine, methionine, and leucine promotes beta-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.	Lysine	26-32	casein beta	Bos taurus	67-78
27581627-6	2017	In the helical domain of PIK3CA, the lysine substitution at 542-545 positions was significantly studied in causing breast cancer.	Lysine	37-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	25-31
28647331-8	2017	The optimum conditions for beta-casein expression are found to be 5.47 mM of His, 7.48 mM of Lys, 1.17 mM of Met, and 8.21 mM of Leu (His:Lys:Met:Leu = 5:6:1:7) in the designed scope of concentration.	Lysine	93-96	casein beta	Bos taurus	27-38
28647331-8	2017	The optimum conditions for beta-casein expression are found to be 5.47 mM of His, 7.48 mM of Lys, 1.17 mM of Met, and 8.21 mM of Leu (His:Lys:Met:Leu = 5:6:1:7) in the designed scope of concentration.	Lysine	138-141	casein beta	Bos taurus	27-38
28647331-15	2017	In conclusion, the extracellular concentrations of His, Lys, Met, and Leu at a ratio of 5:6:1:7 maximized beta-casein expression in the immortalized bovine mammary epithelial cell line may occur via activation of the mechanistic target of rapamycin complex 1 signaling pathway.	Lysine	56-59	casein beta	Bos taurus	106-117
28655792-4	2017	C646 treatment blocked acetylation of specific lysine residues that regulate p53 activity.	Lysine	47-53	tumor protein p53	Homo sapiens	77-80
28627122-6	2017	The alanine scanning and shuffling the amino acid residues of BP4 (Tyr-Lys-Asp-Gly) demonstrated that the Tyr-Lys-Asp-Gly consensus sequence is important for the inhibitory effect of the peptide on hypothermia.	Lysine	71-74	Blood pressure QTL 4	Rattus norvegicus	62-65
28012236-5	2017	Meanwhile, Lys deprivation upregulated pept1 expression, which might improve Lys-Lys dipeptide absorption to compensate for the reduced Lys availability.	Lysine	11-14	solute carrier family 15 member 1	Homo sapiens	39-44
28012236-5	2017	Meanwhile, Lys deprivation upregulated pept1 expression, which might improve Lys-Lys dipeptide absorption to compensate for the reduced Lys availability.	Lysine	77-80	solute carrier family 15 member 1	Homo sapiens	39-44
28648598-4	2017	This mechanism involves the binding of t-PA via a lysine-dependent mechanism to the Lys91 residue of the MBP NH2-terminal region Asp82 -Pro99, and the binding of Pg via a lysine-dependent mechanism to the Lys122 residue of the MBP COOH-terminal region Leu109-Gly126.	Lysine	50-56	plasminogen activator, tissue type	Homo sapiens	39-43
29109776-3	2017	In this system (designated DGLipo NPs), doxorubicin (Dox) was intercalated into the DNA duplex containing a Cyt c aptamer, which subsequently loaded in the dendrigraftpoly-L-lysines (DGL) cores of DGLipo NPs, while cyclopeptide RA-V was doped into the pH-sensitive liposomal shells.	Lysine	171-181	cytochrome c, somatic	Homo sapiens	108-113
28628306-0	2017	Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.	Lysine	0-6	histone deacetylase 6	Homo sapiens	24-29
28628306-0	2017	Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.	Lysine	0-6	AKT serine/threonine kinase 1	Homo sapiens	63-66
28628306-4	2017	Recently, lysine residues (Lys14 and Lys20) on AKT, located within its pleckstrin homology (PH) domain that binds to membrane-bound PIP3, have been found to be acetylated under certain cellular contexts in various cancer cell lines.	Lysine	10-16	AKT serine/threonine kinase 1	Homo sapiens	47-50
28527696-3	2017	We previously reported that the histone 3 lysine 9 (H3K9) methyltransferase (MTase) G9a is specifically enriched in the tooth mesenchyme during mouse development.	Lysine	42-48	DNA methyltransferase (cytosine-5) 1	Mus musculus	77-82
28733487-4	2017	The histone methyltransferase mixed-lineage leukemia 1 (MLL1) preferentially modifies lysine residue 4 on the unstructured protein tail of histone H3.	Lysine	86-92	lysine (K)-specific methyltransferase 2A	Mus musculus	30-54
28733487-4	2017	The histone methyltransferase mixed-lineage leukemia 1 (MLL1) preferentially modifies lysine residue 4 on the unstructured protein tail of histone H3.	Lysine	86-92	lysine (K)-specific methyltransferase 2A	Mus musculus	56-60
28576046-7	2017	The Gaussian curve fit (GCF) of amide I band were revealed that VEGF efficiently interact through the alpha-helix of the amphiphilic graft copolymer rather than beta-sheet dominated poly(l-lysine).	Lysine	187-195	vascular endothelial growth factor A	Homo sapiens	64-68
28839270-10	2017	Activation of ERK1/2 by ceramide, known to increase lysine acetylation, appears to be mediated by acetylation-dependent stabilization of IQGAP1.	Lysine	52-58	mitogen-activated protein kinase 3	Homo sapiens	14-20
28676499-6	2017	Our results revealed that Lys-776, located in the P-loop of PI3Kalpha, is essential for the recognition of lipid and ATP substrates and also plays an important role in PI3Kalpha autophosphorylation.	Lysine	26-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	60-69
28676499-6	2017	Our results revealed that Lys-776, located in the P-loop of PI3Kalpha, is essential for the recognition of lipid and ATP substrates and also plays an important role in PI3Kalpha autophosphorylation.	Lysine	26-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	168-177
28607149-2	2017	Polycomb repressive complex 2 (PRC2) is responsible for methylation of histone H3 lysine 27 (H3K27), and trimethylated H3K27 (H3K27me3) is implicated in epigenetic gene silencing.	Lysine	82-88	proteasome core particle subunit alpha 1	Saccharomyces cerevisiae S288C	31-35
28571745-5	2017	Acetylation of MKL1 was necessary for MKL1 to activate the transcription of pro-inflammatory genes because mutation of four conserved lysine residues in MKL1 attenuated its capacity as a trans-activator of NF-kappaB target genes.	Lysine	134-140	nuclear factor kappa B subunit 1	Homo sapiens	206-215
29228645-4	2017	Sumoylation of Snail1 lysine residue 234 confers its transcriptional activity, inducing the expression of classical EMT genes, as well as TGFbeta receptor I (TbetaRI) and the transcriptional repressor Hes1.	Lysine	22-28	snail family transcriptional repressor 1	Homo sapiens	15-21
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	21-27	signal transducer and activator of transcription 3	Mus musculus	0-5
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	21-27	signal transducer and activator of transcription 3	Mus musculus	82-87
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	35-41	signal transducer and activator of transcription 3	Mus musculus	82-87
28487115-7	2017	Further investigation revealed that HOXD-AS1 recruited WDR5 to directly regulate the expression of target genes by mediating histone H3 lysine 4 tri-methylation (H3K4me3).	Lysine	136-142	WD repeat domain 5	Homo sapiens	55-59
28391248-6	2017	Among non-carrier mothers, increased risk of RA was associated with having children who carried DERAA (OR 1.7; 95% CI 1.0 to 2.7) and alleles encoding lysine at DRB1 position 71 (OR 2.3; 95% CI 1.5 to 4.8).	Lysine	151-157	major histocompatibility complex, class II, DR beta 1	Homo sapiens	161-165
28450045-0	2017	Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes.	Lysine	9-15	cathelicidin antimicrobial peptide	Homo sapiens	39-44
29069809-5	2017	Normally, p16 transcription is tightly controlled at the epigenetic level via polycomb repressive complex-mediated tri-methylation of histone 3 lysine 27 (H3K27me3).	Lysine	144-150	cyclin dependent kinase inhibitor 2A	Homo sapiens	10-13
28760201-1	2017	SUV39H is the major histone H3 lysine 9 (H3K9)-specific methyltransferase that targets pericentric regions and is crucial for assembling silent heterochromatin.	Lysine	31-37	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-6
28536275-2	2017	In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation.	Lysine	77-83	sirtuin 3	Homo sapiens	38-43
28536275-2	2017	In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation.	Lysine	77-83	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	69-73
28536275-2	2017	In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation.	Lysine	77-83	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	89-93
28536275-2	2017	In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation.	Lysine	77-83	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	89-93
27453381-8	2017	However, NF1 have additionally formed a single hydrogen bond with LYS 413.	Lysine	66-69	neurofibromin 1	Homo sapiens	9-12
27494802-2	2017	The lysine residues of Bromodomain-1 (BD1) of Brd4 undergo epsilon-N-Acetylation posttranslational modifications to control transcription of genes.	Lysine	4-10	bromodomain containing 4	Homo sapiens	46-50
27494802-4	2017	In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations.	Lysine	131-137	bromodomain containing 4	Homo sapiens	167-171
28546420-4	2017	We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter.	Lysine	140-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-37
28546420-4	2017	We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter.	Lysine	260-266	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-37
28556566-1	2017	A subset of B-cell lymphoma patients have dominant mutations in the histone H3 lysine 27 (H3K27) methyltransferase EZH2, which change it from a monomethylase to a trimethylase.	Lysine	79-85	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	115-119
28374134-2	2017	It has previously been shown that knockout of lysine 63 deubiquitinase CYLD significantly inhibits necroptosis in other cell lines, and serum response factor (SRF) could regulate CYLD gene expression through p38 mitogen-activated protein kinase (p38 MAPK).	Lysine	46-52	mitogen-activated protein kinase 14	Homo sapiens	246-254
28759577-2	2017	The repression of FLC is mediated by increased enrichment of Polycomb Repressive Complex 2 (PRC2) and subsequent trimethylation of Histone H3 Lysine 27 (H3K27me3) at FLC chromatin.	Lysine	142-148	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	18-21
28580685-6	2017	Specifically, YY1 overexpression helps to maintain markers of gene activation such as the acetylation of histone H3 at lysine 9 (H3K9Ac) and lysine 27 (H3K27Ac) as well as trimethylation at lysine 4 (H3K4Me3) at the Nkx2-5 cardiac enhancer.	Lysine	119-125	YY1 transcription factor	Homo sapiens	14-17
28580685-6	2017	Specifically, YY1 overexpression helps to maintain markers of gene activation such as the acetylation of histone H3 at lysine 9 (H3K9Ac) and lysine 27 (H3K27Ac) as well as trimethylation at lysine 4 (H3K4Me3) at the Nkx2-5 cardiac enhancer.	Lysine	141-147	YY1 transcription factor	Homo sapiens	14-17
28580685-6	2017	Specifically, YY1 overexpression helps to maintain markers of gene activation such as the acetylation of histone H3 at lysine 9 (H3K9Ac) and lysine 27 (H3K27Ac) as well as trimethylation at lysine 4 (H3K4Me3) at the Nkx2-5 cardiac enhancer.	Lysine	141-147	YY1 transcription factor	Homo sapiens	14-17
28759577-2	2017	The repression of FLC is mediated by increased enrichment of Polycomb Repressive Complex 2 (PRC2) and subsequent trimethylation of Histone H3 Lysine 27 (H3K27me3) at FLC chromatin.	Lysine	142-148	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	166-169
28753655-5	2017	NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation.	Lysine	73-76	mitogen-activated protein kinase 8	Homo sapiens	13-16
28754964-1	2017	EZH2, a subunit of the polycomb repressive complex 2 (PRC2) catalyzing trimethylation of histone H3 lysine 27 (H3K27), induces epithelial-mesenchymal transition (EMT) in cancers.	Lysine	100-106	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
28753655-5	2017	NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation.	Lysine	73-76	mitogen-activated protein kinase 8	Homo sapiens	91-94
28753655-5	2017	NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation.	Lysine	73-76	mitogen-activated protein kinase 8	Homo sapiens	104-108
28753655-5	2017	NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation.	Lysine	73-76	mitogen-activated protein kinase 8	Homo sapiens	91-94
28640323-4	2017	Mutation of one, two, or three Lys residues or the Arg residue alone decreased the catalytic efficiency of TAFI activation by thrombin-TM by 2.4-, 3.2-, 4.7-, and 15.0-fold, respectively, and increased the TAFI concentrations required for half-maximal prolongation of clot lysis times (K1/2) by 3-, 4,- 15-, and 24-fold, respectively.	Lysine	31-34	coagulation factor II, thrombin	Homo sapiens	126-134
29137252-11	2017	Overexpression of the mutant MeCP2 in cultured neuroblastoma cells SH-SY5Y revealed increased level of dimethylated histone 3 lysine 9, a transcriptional repressor marker.	Lysine	126-132	methyl-CpG binding protein 2	Homo sapiens	29-34
28753426-4	2017	Mechanistically, SETD2 directly mediates STAT1 methylation on lysine 525 via its methyltransferase activity, which reinforces IFN-activated STAT1 phosphorylation and antiviral cellular response.	Lysine	62-68	SET domain containing 2	Mus musculus	17-22
28751674-7	2017	The receptor-binding results revealed that honokiol repressed FPR1-specific ligand N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein binding to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells.	Lysine	112-115	formyl peptide receptor 1	Homo sapiens	62-66
28751674-7	2017	The receptor-binding results revealed that honokiol repressed FPR1-specific ligand N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein binding to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells.	Lysine	112-115	formyl peptide receptor 1	Homo sapiens	139-143
28751674-7	2017	The receptor-binding results revealed that honokiol repressed FPR1-specific ligand N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein binding to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells.	Lysine	112-115	formyl peptide receptor 1	Homo sapiens	199-204
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	11-14	coagulation factor II, thrombin	Homo sapiens	95-103
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	19-22	coagulation factor II, thrombin	Homo sapiens	95-103
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	19-22	coagulation factor II, thrombin	Homo sapiens	95-103
28740167-6	2017	Importantly, mutating lysine 896 in CtIP recapitulates the CBX4-depletion phenotype, blocks homologous recombination and increases genomic instability.	Lysine	22-28	RB binding protein 8, endonuclease	Homo sapiens	36-40
28740167-9	2017	In summary, sumoylation of CtIP at lysine 896 defines a subpopulation of the protein that is involved in DNA resection and recombination.The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery.	Lysine	35-41	RB binding protein 8, endonuclease	Homo sapiens	27-31
28277940-4	2017	Co-opting this principle to CRMP2, we demonstrate that, of 3 sites predicted to be SUMOylated in CRMP2, only the lysine 374 site is a SUMOylation client.	Lysine	113-119	dihydropyrimidinase-like 2	Mus musculus	28-33
28472910-10	2017	The superimposition of wild onto mutated V600E BRAF revealed helix-coil transition occurring wherein residues Val 502, Leu 505, Arg506, Lys 507 assumed coiled conformation in the mutated BRAF.	Lysine	136-139	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	47-51
28472910-10	2017	The superimposition of wild onto mutated V600E BRAF revealed helix-coil transition occurring wherein residues Val 502, Leu 505, Arg506, Lys 507 assumed coiled conformation in the mutated BRAF.	Lysine	136-139	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	187-191
28549889-2	2017	We have previously developed inhibitors of BRD4, which recognizes acetylated lysine residue on histones and recruits transcription elongation factor to the transcription start site, while inhibitors of histone deacetylase (HDAC), which catalyzes the removal of acetyl groups on histones, are already in clinical use for cancer treatment.	Lysine	77-83	bromodomain containing 4	Homo sapiens	43-47
28421257-7	2017	Further, histone acetylation was reduced while histone tri-methylation was increased at specific lysine residues of H3 and H4 within the Drd2 promoter in the striatum of aged mice.	Lysine	97-103	dopamine receptor D2	Mus musculus	137-141
28277940-6	2017	A 1.78-A-resolution crystal structure of mouse CRMP2 was solved using X-ray crystallography, revealing lysine 374 as buried within the CRMP2 tetramer interface but exposed in the monomer.	Lysine	103-109	dihydropyrimidinase-like 2	Mus musculus	47-52
28639641-2	2017	Biological studies have highlighted the importance of the glycosylated lysine residues for the formation of bioactive high molecular weight oligomers of Adpn.	Lysine	71-77	adiponectin, C1Q and collagen domain containing	Homo sapiens	153-157
28277940-6	2017	A 1.78-A-resolution crystal structure of mouse CRMP2 was solved using X-ray crystallography, revealing lysine 374 as buried within the CRMP2 tetramer interface but exposed in the monomer.	Lysine	103-109	dihydropyrimidinase-like 2	Mus musculus	135-140
28639641-3	2017	Through the use of "click" glycopeptide mimetics, we investigated the role of glycosylated lysine and serine residues for the formation of triple helical structures of the collagenous domain of Adpn, in the context of a collagen model peptide scaffold.	Lysine	91-97	adiponectin, C1Q and collagen domain containing	Homo sapiens	194-198
28639641-5	2017	Our results highlight the crucial role of lysine residues for formation of the triple helical structure of Adpn, possibly due to the extension of both intra- and interstrand hydrogen bonding networks.	Lysine	42-48	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-111
28674400-3	2017	In naive BMMCs, LPS stimulation induced a transient decline in the trimethylation of lysine 9 of the core histone H3 (H3K9me3), a suppressive chromatin mark, at the Il6/Tnf promoters, which correlated with p50(NFkappaB) and p65(NFkappaB) binding.	Lysine	85-91	interleukin 6	Mus musculus	165-168
28639641-6	2017	Strikingly, we observed a significant decrease in thermal stability upon incorporation of triazole-linked analogues of glycosylated lysine residues into the adiponectin collageneous domain, indicating possible uses of "click" glycomimetics for bioengineering applications.	Lysine	132-138	adiponectin, C1Q and collagen domain containing	Homo sapiens	157-168
28433661-5	2017	LC-MS/MS analysis indicated the presence of four acetylated lysines in matrix SOD2 and nine acetylated lysines in cytosolic SOD2 from the SOD2-tg heart.	Lysine	60-67	superoxide dismutase 2, mitochondrial	Mus musculus	78-82
28296337-8	2017	LC-MS identified carbamylation of 9 of 34 lysines in the human fibrinogen beta-chain.	Lysine	42-49	fibrinogen beta chain	Homo sapiens	63-84
28639750-4	2017	We found that SMYD3 trimethylates HER2 protein at lysine 175.	Lysine	50-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
28639750-5	2017	HER2 homodimerization was enhanced in the presence of SMYD3, and substitution of lysine 175 of HER2 with alanine (HER2-K175A) reduced the formation of HER2 homodimers.	Lysine	81-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
28639750-5	2017	HER2 homodimerization was enhanced in the presence of SMYD3, and substitution of lysine 175 of HER2 with alanine (HER2-K175A) reduced the formation of HER2 homodimers.	Lysine	81-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
28639750-5	2017	HER2 homodimerization was enhanced in the presence of SMYD3, and substitution of lysine 175 of HER2 with alanine (HER2-K175A) reduced the formation of HER2 homodimers.	Lysine	81-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99
28639750-8	2017	Our results imply that SMYD3-mediated methylation of HER2 at Lysine 175 may regulate the formation of HER2 homodimer and subsequent autophosphorylation and suggest that the SMYD3-mediated methylation pathway seems to be a good target for development of novel anti-cancer therapy.	Lysine	61-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
28639750-8	2017	Our results imply that SMYD3-mediated methylation of HER2 at Lysine 175 may regulate the formation of HER2 homodimer and subsequent autophosphorylation and suggest that the SMYD3-mediated methylation pathway seems to be a good target for development of novel anti-cancer therapy.	Lysine	61-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
28315733-6	2017	Moreover, EZH2-mediated silencing of SFRP-1 was due to increased histone 3 lysine 27 trimethylation (H3K27me3) on its promoter region.	Lysine	75-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	10-14
28285006-7	2017	Conversion of lysine to arginine at these two sites did not affect subcellular localization, but did affect the transcriptional activity of GATA5.	Lysine	14-20	GATA binding protein 5	Danio rerio	140-145
28511912-5	2017	Under TNF-alpha stimulation, Atractylodin induced the tri-methylation of histone H3 at lysine residue 9, which impaired the binding between NF-kappaB and the IL-6 promoter on the genomic DNA.	Lysine	87-93	tumor necrosis factor	Homo sapiens	6-15
28511912-5	2017	Under TNF-alpha stimulation, Atractylodin induced the tri-methylation of histone H3 at lysine residue 9, which impaired the binding between NF-kappaB and the IL-6 promoter on the genomic DNA.	Lysine	87-93	interleukin 6	Homo sapiens	158-162
28433661-5	2017	LC-MS/MS analysis indicated the presence of four acetylated lysines in matrix SOD2 and nine acetylated lysines in cytosolic SOD2 from the SOD2-tg heart.	Lysine	103-110	superoxide dismutase 2, mitochondrial	Mus musculus	124-128
28433661-5	2017	LC-MS/MS analysis indicated the presence of four acetylated lysines in matrix SOD2 and nine acetylated lysines in cytosolic SOD2 from the SOD2-tg heart.	Lysine	103-110	superoxide dismutase 2, mitochondrial	Mus musculus	124-128
28420800-2	2017	Previous studies have revealed that SETDB1 catalyzes lysine 9 of histone H3 tri-methylation and plays essential roles in maintaining the survival of embryonic stem cells and spermatogonial stem cells in mice.	Lysine	53-59	SET domain, bifurcated 1	Mus musculus	36-42
27922192-1	2017	Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Delta1 -piperideine-6-carboxylate (P6C) by the flavoenzyme l-pipecolate oxidase (PIPOX).	Lysine	35-41	pipecolic acid and sarcosine oxidase	Homo sapiens	135-155
27922192-1	2017	Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Delta1 -piperideine-6-carboxylate (P6C) by the flavoenzyme l-pipecolate oxidase (PIPOX).	Lysine	35-41	pipecolic acid and sarcosine oxidase	Homo sapiens	157-162
27922192-6	2017	Subcellular fractionation analysis showed that PIPOX is localized in the mitochondria of HEK293 cells consistent with its role in lysine catabolism.	Lysine	130-136	pipecolic acid and sarcosine oxidase	Homo sapiens	47-52
28592515-0	2017	Intragastric Lysine Lowers the Circulating Glucose and Insulin Responses to a Mixed-Nutrient Drink without Slowing Gastric Emptying in Healthy Adults.	Lysine	13-19	insulin	Homo sapiens	55-62
28592515-8	2017	Lysine did not slow gastric emptying, and there was no effect on energy intake.Conclusion: In healthy adults, lysine slightly reduced the glycemic response to an oral mixed-macronutrient drink, an effect that was apparently independent of insulin or slowing of gastric emptying.	Lysine	110-116	insulin	Homo sapiens	239-246
28511916-7	2017	Quantitative chromatin immunoprecipitation assay revealed that amitriptyline increased enrichments of trimethylation of histone H3 lysine 4 in the promoter regions of Atf3 and Hmox1 and acetylation of histone H3 lysine 9 in the promoter regions of Atf3, which indicate an active epigenetic status.	Lysine	131-137	heme oxygenase 1	Mus musculus	176-181
28671020-0	2017	The Wnt/beta-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation.	Lysine	115-121	AKT serine/threonine kinase 1	Homo sapiens	30-33
28300602-4	2017	The Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain is an emerging reader module that selectively recognizes histone lysine acylation with a preference for crotonylation over acetylation.	Lysine	112-118	MLLT3 super elongation complex subunit	Homo sapiens	15-18
28587732-3	2017	has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.	Lysine	68-74	sirtuin 4	Homo sapiens	38-43
28383693-1	2017	In plants, the histone H3.1 lysine 27 (H3K27) mono-methyltransferases ARABIDOPSIS TRITHORAX RELATED PROTEIN 5 and 6 (ATXR5/6) regulate heterochromatic DNA replication and genome stability.	Lysine	28-34	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	82-115
28461393-7	2017	The acetylation of CREBH at lysine residue 294 controls CREBH-PPARalpha interaction and synergy in regulating hepatic glucose metabolism in mice.	Lysine	28-34	peroxisome proliferator activated receptor alpha	Mus musculus	62-71
28438779-6	2017	Moreover, interleukin-4 polarization lowers expression levels of the osteoclast transcriptional activator nuclear factor of activated T cells type c-1, associated with increased gene promoter levels of the transcriptional repression mark H3K27me3 (histone 3 lysine 27 trimethylation).	Lysine	258-264	interleukin 4	Homo sapiens	10-23
28483520-4	2017	Here we validated the deubiquitinating activity of PPPDE1 and revealed its isopeptidase activity against ubiquitin conjugated through Lys 48 and Lys 63.	Lysine	134-137	desumoylating isopeptidase 2	Homo sapiens	51-57
28483520-4	2017	Here we validated the deubiquitinating activity of PPPDE1 and revealed its isopeptidase activity against ubiquitin conjugated through Lys 48 and Lys 63.	Lysine	145-148	desumoylating isopeptidase 2	Homo sapiens	51-57
28483520-6	2017	Moreover, PPPDE1 could mediate the ubiquitin chain editing of RPS7, deubiquitinating Lys 48-linked ubiquitination, and finally stabilize RPS7 proteins.	Lysine	85-88	desumoylating isopeptidase 2	Homo sapiens	10-16
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	100-103	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	108-111	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	108-111	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	108-111	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	108-111	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28461335-3	2017	We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 &gt; Lys-48 &gt; Lys-11).	Lysine	108-111	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	46-50
28476883-10	2017	We further demonstrated that HOTAIR regulates DR5 expression via the epigenetic regulator enhancer of zeste homolog 2 (EZH2) and that EZH2 controls histone H3 lysine 27 trimethylation on the DR5 gene.	Lysine	159-165	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	134-138
28383693-1	2017	In plants, the histone H3.1 lysine 27 (H3K27) mono-methyltransferases ARABIDOPSIS TRITHORAX RELATED PROTEIN 5 and 6 (ATXR5/6) regulate heterochromatic DNA replication and genome stability.	Lysine	28-34	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	117-124
28596365-3	2017	PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide.	Lysine	169-175	polycomb group ring finger 3	Homo sapiens	0-5
28623334-5	2017	TIP60 utilizes its NR Box to interact with LBD region of PXR and acetylates PXR at lysine 170 to induce its intranuclear reorganization.	Lysine	83-89	nuclear receptor subfamily 1 group I member 2	Homo sapiens	76-79
28344045-10	2017	Based on EZH2 methyltransferase activity and the potential methylation sites in alpha-actin structure, we revealed that alpha-actin was lysine-methylated.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	9-13
28450392-10	2017	Furthermore, stabilization of NSL3 by OGT1-WT significantly increased the global acetylation levels of H4 Lys-5, Lys-8, and Lys-16 in cells.	Lysine	106-109	KAT8 regulatory NSL complex subunit 3	Homo sapiens	30-34
28450392-10	2017	Furthermore, stabilization of NSL3 by OGT1-WT significantly increased the global acetylation levels of H4 Lys-5, Lys-8, and Lys-16 in cells.	Lysine	113-116	KAT8 regulatory NSL complex subunit 3	Homo sapiens	30-34
28620234-2	2017	EZH2 silences gene expression by tri-methylating the lysine 27 residue of histone H3 (H3K27me3).	Lysine	53-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
28474881-0	2017	Remote Perturbations in Tertiary Contacts Trigger Ligation of Lysine to the Heme Iron in Cytochrome c.	Lysine	62-68	cytochrome c, somatic	Homo sapiens	89-101
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	CREB binding protein	Homo sapiens	56-76
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	CREB binding protein	Homo sapiens	78-81
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	nuclear factor kappa B subunit 1	Homo sapiens	156-165
28626565-5	2017	Using bromodomain-containing protein 4 (BRD4) as a paradigm, we engineer an "aromatic cage" of the bromodomain to introduce 4-azido-l-phenylalanine (pAzF) without compromising its ability to recognize acetylated lysine residues in histone proteins.	Lysine	212-218	bromodomain containing 4	Homo sapiens	6-38
28382372-7	2017	S100A10 retains activity after substitution or deletion of the carboxyl-terminal lysine suggesting that internal lysine residues contribute to its plasmin generating activity.	Lysine	81-87	S100 calcium binding protein A10	Homo sapiens	0-7
28382372-7	2017	S100A10 retains activity after substitution or deletion of the carboxyl-terminal lysine suggesting that internal lysine residues contribute to its plasmin generating activity.	Lysine	113-119	S100 calcium binding protein A10	Homo sapiens	0-7
28626565-5	2017	Using bromodomain-containing protein 4 (BRD4) as a paradigm, we engineer an "aromatic cage" of the bromodomain to introduce 4-azido-l-phenylalanine (pAzF) without compromising its ability to recognize acetylated lysine residues in histone proteins.	Lysine	212-218	bromodomain containing 4	Homo sapiens	40-44
28458162-2	2017	PCNA can be monoubiquitylated at lysine 164 by the RAD6-RAD18 ubiquitin ligase complex.	Lysine	33-39	proliferating cell nuclear antigen	Gallus gallus	0-4
28364255-14	2017	Albumin-induced miR-184 expression in tubule cells was epigenetically regulated through DNA demethylation and histone lysine acetylation and was accompanied by binding of NF-kappaB p65 subunit to miR-184 promoter.	Lysine	118-124	microRNA 184	Rattus norvegicus	16-23
28458162-4	2017	Monoubiquitylated PCNA can be polyubiquitylated on lysine 63 of ubiquitin by a further ubiquitin-conjugating complex.	Lysine	51-57	proliferating cell nuclear antigen	Gallus gallus	18-22
28458162-10	2017	The expression of a PCNAK164R-ubiquitinK63R fusion protein, on which the formation of lysine 63-linked polyubiquitin chains is not possible, similarly rescued the cell cycle arrest, DNA damage sensitivity, reduction of translesion synthesis and increase of MMS-induced genomic mutagenesis.	Lysine	86-92	polyubiquitin	Gallus gallus	103-116
28258188-4	2017	Several proteomics studies have identified 4 lysine residues in critical regions of mammalian GAPDH that are altered by multiple post-translational modifications.	Lysine	45-51	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	94-99
28229514-2	2017	EZH2 and EED are core components of the polycomb repressive complex 2 (PRC2), which possesses histone methyltransferase activity and catalyzes trimethylation of histone H3 at lysine 27.	Lysine	175-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
28391595-2	2017	Here, we describe that lysine-368 of human citrate synthase is methylated and that the modifying enzyme, localized in the mitochondrial matrix, is methyltransferase-like protein 12 (METTL12), a member of the family of 7beta-strand methyltransferases.	Lysine	23-29	citrate synthase lysine methyltransferase	Homo sapiens	147-180
28391595-2	2017	Here, we describe that lysine-368 of human citrate synthase is methylated and that the modifying enzyme, localized in the mitochondrial matrix, is methyltransferase-like protein 12 (METTL12), a member of the family of 7beta-strand methyltransferases.	Lysine	23-29	citrate synthase lysine methyltransferase	Homo sapiens	182-189
28561778-1	2017	Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery.	Lysine	108-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
28284523-3	2017	Demethylase Kdm6a promotes gene transcription in cell-lineage specification through demethylating histone H3 lysine di/tri-methylation (H3K27me2/3), and loss of Kdm6a results in developmental defects.	Lysine	109-115	lysine demethylase 6A	Homo sapiens	12-17
28291659-8	2017	A1AT contains several lysines on the protein surface that can readily be carbamylated.	Lysine	22-29	serpin family A member 1	Homo sapiens	0-4
28438900-4	2017	A hydrolyzed piperacillin hapten was detected on four lysine residues of human serum albumin (HSA) isolated from tolerant patients.	Lysine	54-60	albumin	Homo sapiens	79-92
28285099-5	2017	Mechanistically, the over-expression of miR-1247 is associated with a markedly increase in histone H3 lysine 4 trimethylation in the upstream region of the Mir1247 gene.	Lysine	102-108	microRNA 1247	Mus musculus	40-48
28285099-5	2017	Mechanistically, the over-expression of miR-1247 is associated with a markedly increase in histone H3 lysine 4 trimethylation in the upstream region of the Mir1247 gene.	Lysine	102-108	microRNA 1247	Mus musculus	156-163
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	214-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-148
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	246-252	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-148
28561778-1	2017	Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery.	Lysine	108-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
28377500-3	2017	Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is regulated by proteolytic cleavage and Lys-63-polyubiquitination.	Lysine	118-121	immune deficiency	Drosophila melanogaster	0-3
28422741-4	2017	The CaM-interacting site of TBC1D3 was mapped to amino acids 157~171, which comprises two 1-14 hydrophobic motifs and one lysine residue (K166).	Lysine	122-128	calmodulin 1	Homo sapiens	4-7
28422741-4	2017	The CaM-interacting site of TBC1D3 was mapped to amino acids 157~171, which comprises two 1-14 hydrophobic motifs and one lysine residue (K166).	Lysine	122-128	TBC1 domain family member 3	Homo sapiens	28-34
28422741-7	2017	In agreement with this, we identified lysine residue 166 within the CaM-interacting motifs of TBC1D3 as the actual site for the GF signaling-induced ubiquitination using mutational analysis.	Lysine	38-44	calmodulin 1	Homo sapiens	68-71
28422741-7	2017	In agreement with this, we identified lysine residue 166 within the CaM-interacting motifs of TBC1D3 as the actual site for the GF signaling-induced ubiquitination using mutational analysis.	Lysine	38-44	TBC1 domain family member 3	Homo sapiens	94-100
28422741-8	2017	Point mutation of this lysine residue exhibited the same effect on TBC1D3 as the deletion mutant, suggesting that CaM inhibits GF signaling-induced degradation of TBC1D3 by occluding its ubiquitination at K166.	Lysine	23-29	TBC1 domain family member 3	Homo sapiens	67-73
28422741-8	2017	Point mutation of this lysine residue exhibited the same effect on TBC1D3 as the deletion mutant, suggesting that CaM inhibits GF signaling-induced degradation of TBC1D3 by occluding its ubiquitination at K166.	Lysine	23-29	calmodulin 1	Homo sapiens	114-117
28422741-8	2017	Point mutation of this lysine residue exhibited the same effect on TBC1D3 as the deletion mutant, suggesting that CaM inhibits GF signaling-induced degradation of TBC1D3 by occluding its ubiquitination at K166.	Lysine	23-29	TBC1 domain family member 3	Homo sapiens	163-169
28611663-2	2017	In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (H3K9) marks after injury and stimulation with the pro-fibrotic cytokine TGF-beta1.	Lysine	73-79	transforming growth factor, beta 1	Rattus norvegicus	155-164
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	69-75	Ubiquitin-conjugating enzyme variant 1A	Drosophila melanogaster	156-161
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	0-3	TGF-beta activated kinase 1	Drosophila melanogaster	62-66
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	0-3	immune deficiency	Drosophila melanogaster	103-106
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	TGF-beta activated kinase 1	Drosophila melanogaster	62-66
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	immune deficiency	Drosophila melanogaster	103-106
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	41-44	immune deficiency	Drosophila melanogaster	26-29
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	TGF-beta activated kinase 1	Drosophila melanogaster	62-66
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	immune deficiency	Drosophila melanogaster	103-106
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	41-44	bendless	Drosophila melanogaster	150-155
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	41-44	Ubiquitin-conjugating enzyme variant 1A	Drosophila melanogaster	156-161
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	69-75	immune deficiency	Drosophila melanogaster	26-29
29029401-2	2017	Lysine methylation of histones such as H4K20 and non-histone proteins including p53 has been shown to be essential for the mounting of the DDR.	Lysine	0-6	tumor protein p53	Homo sapiens	80-83
28542143-3	2017	Mutation of these lysine residues completely abrogates the binding of E2F1 to CCNE, TP73 and APAF1 promoters, thus inhibiting transcriptional activation of these genes and E2F1-mediated cell proliferation control.	Lysine	18-24	apoptotic peptidase activating factor 1	Homo sapiens	93-98
28542143-4	2017	Importantly, E2F1 stabilization in response to etoposide-induced DNA damage or during the S phase of cell cycle, as revealed by cyclin A silencing, is associated with K63-poly-ubiquitinylation of E2F1 on lysine 161/164 residues and involves cIAP1.	Lysine	204-210	cyclin A2	Homo sapiens	128-136
28542145-7	2017	TRIM45 conjugates K63-linked polyubiquitin chain to the C-terminal six lysine residues of p53, thereby inhibiting the availability of these residues to the K48-linked polyubiquitination that targets p53 for degradation.	Lysine	71-77	tumor protein p53	Homo sapiens	90-93
28542145-7	2017	TRIM45 conjugates K63-linked polyubiquitin chain to the C-terminal six lysine residues of p53, thereby inhibiting the availability of these residues to the K48-linked polyubiquitination that targets p53 for degradation.	Lysine	71-77	tumor protein p53	Homo sapiens	199-202
27358484-4	2017	Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis.	Lysine	45-51	TNF superfamily member 10	Homo sapiens	97-102
28529077-2	2017	Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here we greatly updated our previous studies, and presented a much more integrative resource of protein lysine modification database (PLMD).	Lysine	205-211	FXYD domain containing ion transport regulator 1	Homo sapiens	48-51
28529077-2	2017	Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here we greatly updated our previous studies, and presented a much more integrative resource of protein lysine modification database (PLMD).	Lysine	205-211	FXYD domain containing ion transport regulator 1	Homo sapiens	90-93
28529077-5	2017	Moreover, various PLMs synergistically orchestrate specific cellular biological processes by mutual crosstalks with each other, and we totally found 65,297 PLM events involved in 90 types of PLM co-occurrences on the same lysine residues.	Lysine	222-228	FXYD domain containing ion transport regulator 1	Homo sapiens	18-21
28529077-5	2017	Moreover, various PLMs synergistically orchestrate specific cellular biological processes by mutual crosstalks with each other, and we totally found 65,297 PLM events involved in 90 types of PLM co-occurrences on the same lysine residues.	Lysine	222-228	FXYD domain containing ion transport regulator 1	Homo sapiens	156-159
28496150-4	2017	Chromatin immunoprecipitation sequencing (ChIP-seq) and immunological evidence established elevated PARTICLE expression linked to increased histone 3 lysine 27 trimethylation.	Lysine	150-156	promoter of MAT2A antisense radiation-induced circulating long non-coding RNA	Homo sapiens	100-108
28302719-3	2017	Here we found that enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 lysine 27 at the promoter of the 11beta-HSD2 gene.	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	19-46
28496150-3	2017	It now emerges that PARTICLE operates as a trans-acting mediator of DNA and histone lysine methylation.	Lysine	84-90	promoter of MAT2A antisense radiation-induced circulating long non-coding RNA	Homo sapiens	20-28
28302719-3	2017	Here we found that enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 lysine 27 at the promoter of the 11beta-HSD2 gene.	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	48-52
28302719-5	2017	As a result of inactivation of the pRB-E2F1-EZH2 pathway, the repressive marker trimethylation of histone H3 lysine 27 at the 11beta-HSD2 promoter is removed, which leads to the robust expression of 11beta-HSD2 during syncytialization.	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	44-48
28338656-5	2017	Among these genes, we showed that FAK silencing decreased transcription and nuclear localization of enhancer of zeste homolog 2 (EZH2) and its tri-methylation activity on lysine 27 of histone H3 (H3K27me3).	Lysine	171-177	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	100-127
28498016-3	2017	VIN3 is induced by long-term cold and is necessary for Polycomb Repression Complex 2 (PRC2)-mediated tri-methylation of Histone H3 Lysine 27 (H3K27me3) at the FLC locus in Arabidopsis.	Lysine	131-137	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	159-162
28498016-5	2017	The acceleration in vernalization response is achieved by increased enrichments of VIN3 and tri-methylation of Histone H3 Lysine 27 (H3K27me3) at the FLC locus without invoking the increased enrichment of Polycomb Repressive Complex 2.	Lysine	122-128	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	150-153
28382370-4	2017	As aggregation and cross-linking of fibrin monomers rely on lysine residues, it is likely that carbamylation impacts fibrinogen processing.	Lysine	60-66	fibrinogen beta chain	Homo sapiens	117-127
28209620-2	2017	Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation.	Lysine	11-17	DOT1 like histone lysine methyltransferase	Homo sapiens	166-171
28108655-0	2017	The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).	Lysine	123-126	EEF1A lysine methyltransferase 3	Homo sapiens	44-52
28108655-3	2017	We here demonstrate, using a wide range of in vitro and in vivo approaches, that the previously uncharacterized human methyltransferase METTL21B specifically targets Lys-165 in eEF1A in an aminoacyl-tRNA- and GTP-dependent manner.	Lysine	166-169	EEF1A lysine methyltransferase 3	Homo sapiens	136-144
28108655-7	2017	In summary, the present study identifies METTL21B as the enzyme responsible for methylation of eEF1A on Lys-165 and shows that this modification is dynamic, inducible and likely of regulatory importance.	Lysine	104-107	EEF1A lysine methyltransferase 3	Homo sapiens	41-49
28416111-4	2017	Through multiple structural analyses we show that S. cerevisiae Nsa1 is composed of an N-terminal seven-bladed WD40 domain followed by a lysine-rich C terminus that extends away from the WD40 domain and is required for nucleolar localization.	Lysine	137-143	ribosome biosynthesis protein NSA1	Saccharomyces cerevisiae S288C	64-68
28347667-3	2017	Through AlphaScreen-based high-throughput screening assay, a novel small molecular inhibitor was identified, and named DCBD-005, which inhibited the binding between BRD4-BD1 and acetylated lysines with an IC50 value of 0.81+-0.03muM.	Lysine	189-196	bromodomain containing 4	Homo sapiens	165-173
28189587-7	2017	In addition, deacetylation of p53 is required to make lysine residues accessible to ubiquitin ligases.	Lysine	54-60	tumor protein p53	Homo sapiens	30-33
28338656-5	2017	Among these genes, we showed that FAK silencing decreased transcription and nuclear localization of enhancer of zeste homolog 2 (EZH2) and its tri-methylation activity on lysine 27 of histone H3 (H3K27me3).	Lysine	171-177	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	129-133
28296173-7	2017	We further mutated lysine 187 for identifying acetylated residue in Snail.	Lysine	19-25	snail family transcriptional repressor 1	Homo sapiens	68-73
28275050-0	2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).	Lysine	33-39	metadherin	Homo sapiens	125-130
28275050-0	2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).	Lysine	33-39	metadherin	Homo sapiens	140-145
28296173-10	2017	Immunoprecipitation and Western blot assay with anti-acetylated lysine antibody were used to confirm that Snail was acetylated by p300.	Lysine	64-70	snail family transcriptional repressor 1	Homo sapiens	106-111
28296173-13	2017	The reduced Snail acetylation level was related to lysine mutation at position 187 of Snail.	Lysine	51-57	snail family transcriptional repressor 1	Homo sapiens	12-17
28296173-13	2017	The reduced Snail acetylation level was related to lysine mutation at position 187 of Snail.	Lysine	51-57	snail family transcriptional repressor 1	Homo sapiens	86-91
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	heat shock protein HSP 90-beta	Sus scrofa	191-199
28400511-3	2017	SHPRH was recruited to the rDNA promoter using its plant homeodomain (PHD), which interacts with histone H3 when the fourth lysine of H3 is not trimethylated.	Lysine	124-130	SNF2 histone linker PHD RING helicase	Homo sapiens	0-5
28430172-2	2017	Recurrent gain-of-function mutations in EZH2 have been described in 25% of FL patients and induce aberrant methylation of histone H3 lysine 27 (H3K27).	Lysine	133-139	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	40-44
28368584-4	2017	The importance of the residue at position 11 for NTS1/NTS2 selectivity was further demonstrated by the design of new NT analogues bearing basic (Lys, Orn) or acid (Asp or Glu) function.	Lysine	145-148	neurotensin	Homo sapiens	49-53
28430144-6	2017	Dietary lysine excess may lead to: (1) decreased muscle protein degradation via the down-regulated DNAJA1, HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA.	Lysine	8-14	heat shock protein HSP 90-alpha	Sus scrofa	107-115
28430144-6	2017	Dietary lysine excess may lead to: (1) decreased muscle protein degradation via the down-regulated DNAJA1, HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA.	Lysine	8-14	heat shock protein 105 kDa	Sus scrofa	117-122
28430144-6	2017	Dietary lysine excess may lead to: (1) decreased muscle protein degradation via the down-regulated DNAJA1, HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA.	Lysine	8-14	malic enzyme 1	Sus scrofa	207-210
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	malic enzyme 1	Sus scrofa	437-440
28176353-4	2017	TRPA1 and TRPV1 channels are activated by intracellular LPA, but not by extracellular LPA following LPA5 receptor activation with an activity of Ca2+ -independent phospholipase A2 and phospholipase D. Intracellular LPA interaction sites of TRPA1 are KK672-673 and KR977-978 (K: lysine, R: arginine).	Lysine	278-284	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	10-15
28131820-5	2017	All the results pointing that arginine and lysine residues of chymase play the most significant role in inhibitor binding revealed by energy decomposition.	Lysine	43-49	chymase 1	Homo sapiens	62-69
28254491-2	2017	To characterize how PRC2"s two methyltransferase subunits, EZH1 and EZH2, regulate histone H3 lysine 27 (H3K27) methylation during germ cell development, we generated mouse models with a germline ablation of EZH1 and/or EHZ2.	Lysine	94-100	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	59-63
28153791-0	2017	HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis.	Lysine	26-33	histone deacetylase 6	Homo sapiens	0-5
28406396-6	2017	Lysine fatty acylation promotes the plasma membrane localization of R-Ras2 and its interaction with phosphatidylinositol 3-kinase PI3K, leading to activated Akt and increased cell proliferation.	Lysine	0-6	AKT serine/threonine kinase 1	Homo sapiens	157-160
28153791-0	2017	HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis.	Lysine	26-33	tumor protein p53	Homo sapiens	19-22
28153791-4	2017	Interestingly, HDAC6 levels inversely correlated with p53 acetylation at lysines 381/382 associated with p53 functional activation.	Lysine	73-80	histone deacetylase 6	Homo sapiens	15-20
28153791-4	2017	Interestingly, HDAC6 levels inversely correlated with p53 acetylation at lysines 381/382 associated with p53 functional activation.	Lysine	73-80	tumor protein p53	Homo sapiens	54-57
28153791-4	2017	Interestingly, HDAC6 levels inversely correlated with p53 acetylation at lysines 381/382 associated with p53 functional activation.	Lysine	73-80	tumor protein p53	Homo sapiens	105-108
28380357-3	2017	In the present study, we find that Keap1/Cullin3 ubiquitinates p62 at lysine 420 within its UBA domain.	Lysine	70-76	kelch like ECH associated protein 1	Homo sapiens	35-40
28216155-6	2017	Promoter analysis and quantitative ChIP analysis demonstrated that FOG1-mediated transcriptional repression of PU.1 would be mediated through a GATA-binding element located at its promoter, accompanied by significantly decreased H3 acetylation at lysine 4 and 9 (K4 and K9) as well as H3K4 trimethylation.	Lysine	247-253	zinc finger protein, FOG family member 1	Homo sapiens	67-71
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Lysine	167-174	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-156
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Lysine	167-174	nuclear factor, erythroid derived 2, like 2	Mus musculus	158-162
27979926-4	2017	We demonstrate that attenuation of CREBBP results in reduced acetylation of histone 3 lysine 18, but has no significant impact on cAMP-dependent target gene expression.	Lysine	86-92	CREB binding protein	Homo sapiens	35-41
28379447-8	2017	Simultaneously, WDR5 depletion significantly decreased the levels of histone H4 lysine 16 acetylation (H4K16ac) and its writer males absent on the first (MOF).	Lysine	80-86	WD repeat domain 5	Homo sapiens	16-20
28324045-5	2017	RNF6 silencing suppressed dihydrotestosterone-induced AR ubiquitination (lysine residue 63) and proliferation and suppressed apoptosis in preantral granulosa cells, with these responses being overcome by the presence of exogenous sKit-L. Taken together, our findings support the notion that RNF6 plays an important role in androgen-induced, follicle-stage-dependent follicle growth and that it acts by facilitating AR-mediated granulosa cell sKit-L expression and proliferation.	Lysine	73-79	ring finger protein 6	Homo sapiens	0-4
28324045-5	2017	RNF6 silencing suppressed dihydrotestosterone-induced AR ubiquitination (lysine residue 63) and proliferation and suppressed apoptosis in preantral granulosa cells, with these responses being overcome by the presence of exogenous sKit-L. Taken together, our findings support the notion that RNF6 plays an important role in androgen-induced, follicle-stage-dependent follicle growth and that it acts by facilitating AR-mediated granulosa cell sKit-L expression and proliferation.	Lysine	73-79	androgen receptor	Homo sapiens	54-56
27847991-4	2017	METHODS: Six triazolylphenyl ureas and their alkyne precursors were synthesized from the Glu-urea-Lys PSMA binding moiety.	Lysine	98-101	folate hydrolase 1	Homo sapiens	102-106
28139855-4	2017	We found a significant metabolic dysregulation including purine, pyrimidine, lysine, and glycerophospholipid metabolism pathways in astrocytes expressing an ALS-causing mutated superoxide dismutase-1 (SOD1) when co-cultured with motoneurons.	Lysine	77-83	superoxide dismutase 1	Homo sapiens	177-199
28214660-4	2017	EZH2 is the histone methyltransferase of lysine 27 of histone H3 (H3K27me3) that forms the catalytic subunit of the polycomb repressive complex 2.	Lysine	41-47	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
30023619-2	2017	In this study, a kind of composite film composed of poly-l-lysine (PLL), heparin (Hep), and Au nanoparitcles (Au nps) has been fabricated to deliver the basic fibroblast growth factor (bFGF) and bone morphogenetic protein-2 (BMP-2) simultaneously.	Lysine	52-65	fibroblast growth factor 2	Homo sapiens	185-189
28263309-3	2017	H3K27M has been shown to inhibit polycomb repressive complex 2 (PRC2), a multiprotein complex responsible for the methylation of H3 at lysine 27 (H3K27me), by binding to its catalytic subunit EZH2.	Lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	192-196
28381185-0	2017	The histone demethylase lysine-specific demethylase-1-mediated epigenetic silence of KLF2 contributes to gastric cancer cell proliferation, migration, and invasion.	Lysine	24-30	Kruppel like factor 2	Homo sapiens	85-89
28381185-8	2017	Mechanistic investigation reveals that tumor suppressor KLF2 is a key downstream target of lysine-specific demethylase-1 in gastric cancer.	Lysine	91-97	Kruppel like factor 2	Homo sapiens	56-60
28381185-9	2017	These findings indicate that lysine-specific demethylase-1 is an important oncogene in gastric cancer, and lysine-specific demethylase-1-mediated epigenetic repression of KLF2 plays a critical role in gastric cancer development and progression, which supports lysine-specific demethylase-1 as a potential therapeutic target in this disease.	Lysine	29-35	Kruppel like factor 2	Homo sapiens	171-175
28381185-9	2017	These findings indicate that lysine-specific demethylase-1 is an important oncogene in gastric cancer, and lysine-specific demethylase-1-mediated epigenetic repression of KLF2 plays a critical role in gastric cancer development and progression, which supports lysine-specific demethylase-1 as a potential therapeutic target in this disease.	Lysine	107-113	Kruppel like factor 2	Homo sapiens	171-175
28381185-9	2017	These findings indicate that lysine-specific demethylase-1 is an important oncogene in gastric cancer, and lysine-specific demethylase-1-mediated epigenetic repression of KLF2 plays a critical role in gastric cancer development and progression, which supports lysine-specific demethylase-1 as a potential therapeutic target in this disease.	Lysine	107-113	Kruppel like factor 2	Homo sapiens	171-175
28135235-2	2017	The catalytic subunit EZH2 methylates histone H3 lysine 27 (H3K27), and its activity is further enhanced by the binding of EED to trimethylated H3K27 (H3K27me3).	Lysine	49-55	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
28567122-5	2017	RESULTS: Our results show that the monomethylated Gln-51 and Lys-53 residues contained in the 47GFGGQTK53 sequence of eL42 and the monomethylated GGQ motif of eRF1 represents the sites of interaction between these two proteins through hydrophobic contacts between methyl groups.	Lysine	61-64	eukaryotic translation termination factor 1	Homo sapiens	159-163
28567122-9	2017	CONCLUSION: Interactions between the monomethylated Gln-51 and Lys-53 residues of the 49GGQTK53 motif of the human eL42 protein and the methylated GGQ motif of eRF1 are likely to play a functional role on translating human 80S ribosomes.	Lysine	63-66	eukaryotic translation termination factor 1	Homo sapiens	160-164
28184004-9	2017	Chromatin immunoprecipitation-PCR detected increased ETS1 and histone 3 lysine 4 trimethylation (H3K4Me3) at the CDKN2A promoter following LPS-induced senescence.	Lysine	72-78	cyclin dependent kinase inhibitor 2A	Homo sapiens	113-119
28329675-2	2017	Here, we show that lysine 49 (K49) of beta-catenin is trimethylated (beta-catMe3) by Ezh2 or acetylated (beta-catAc) by Cbp.	Lysine	19-25	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	85-89
28329675-2	2017	Here, we show that lysine 49 (K49) of beta-catenin is trimethylated (beta-catMe3) by Ezh2 or acetylated (beta-catAc) by Cbp.	Lysine	19-25	CREB binding protein	Homo sapiens	120-123
28327608-4	2017	Chromatin immunoprecipitation revealed that TNF-alpha reduced methylation of histone H3 at lysines 9 and 27 (H3K9 and H3K27), well-known residues involved in gene suppression.	Lysine	91-98	tumor necrosis factor	Mus musculus	44-53
28248093-4	2017	The mitochondrial deacetylase Sirtuin 3 (SIRT3) has been reported to alter ALDH2 lysine acetylation status, yet the mechanism and consequence of this interaction remain unknown.	Lysine	81-87	sirtuin 3	Homo sapiens	30-39
28225177-0	2017	An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.	Lysine	61-67	heat shock protein family A (Hsp70) member 1A	Homo sapiens	29-34
28225177-6	2017	Targeting this lysine could lead to a new design paradigm for HSP72 chemical probes and drugs.	Lysine	15-21	heat shock protein family A (Hsp70) member 1A	Homo sapiens	62-67
28248093-4	2017	The mitochondrial deacetylase Sirtuin 3 (SIRT3) has been reported to alter ALDH2 lysine acetylation status, yet the mechanism and consequence of this interaction remain unknown.	Lysine	81-87	sirtuin 3	Homo sapiens	41-46
28248093-5	2017	The in vitro results presented here provide a novel biochemical approach using stable-isotope dilution mass spectrometry to elucidate which lysine residues are targeted by SIRT3 for deacetylation.	Lysine	140-146	sirtuin 3	Homo sapiens	172-177
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	98-104	calmodulin 1	Homo sapiens	30-33
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	98-104	estrogen receptor 1	Homo sapiens	117-125
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	98-104	estrogen receptor 1	Homo sapiens	243-251
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	127-130	estrogen receptor 1	Homo sapiens	117-125
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	127-130	calmodulin 1	Homo sapiens	30-33
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	136-139	calmodulin 1	Homo sapiens	30-33
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	136-139	estrogen receptor 1	Homo sapiens	117-125
28426094-7	2017	SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation.	Lysine	47-53	cyclin dependent kinase 9	Homo sapiens	88-92
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	136-139	calmodulin 1	Homo sapiens	30-33
28174300-5	2017	Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	136-139	estrogen receptor 1	Homo sapiens	117-125
28159901-10	2017	Furthermore, 53BP1 chromatin occupancy at sites in the Igh locus is B cell specific, is correlated with histone H4 lysine 20 marks, and is subject to chromatin spreading.	Lysine	115-121	transformation related protein 53 binding protein 1	Mus musculus	13-18
28287151-4	2017	Lys-rich sequences (EK3 (AEEEKKK) and EK2R1 (AEEEKRK)) both form SAHs, of which EK2R1 is more helical and thermo-stable suggesting Arg increases stability.	Lysine	0-3	EPH receptor A8	Homo sapiens	20-23
28188730-8	2017	KEY FINDINGS: The unstable plaque formation and lesion apoptotic cells are increased in ApoE-/- mice supplemented with high-methionine (HM), accompanied with a decreased expression of histone H3 lysine 9 dimethylation.	Lysine	195-201	apolipoprotein E	Mus musculus	88-92
28287151-5	2017	Substituting Lys with Arg (or vice versa) in the naturally-occurring myosin-6 SAH similarly increased (or decreased) its stability.	Lysine	13-16	myosin heavy chain 6	Homo sapiens	69-77
28241136-2	2017	Central to all 53BP1 activities is its recruitment to double-strand breaks via the interaction of the tandem Tudor domain with dimethylated lysine 20 of histone H4 (H4K20me2).	Lysine	140-146	BP1	Homo sapiens	17-20
28100776-3	2017	The mechanism of class A beta-lactamases has been studied extensively, revealing Lys-73 and Glu-166 as general bases that assist the catalytic residue Ser-70.	Lysine	81-84	amyloid beta precursor protein	Homo sapiens	23-29
27394142-1	2017	Transglutaminase 2 (TGase 2) catalyzes a crosslink between protein bound-glutamine and -lysine.	Lysine	88-94	transglutaminase 2	Homo sapiens	0-18
28104757-3	2017	Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein.	Lysine	139-145	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
28104757-3	2017	Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein.	Lysine	139-145	gremlin 1, DAN family BMP antagonist	Homo sapiens	41-50
28115524-0	2017	P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA.	Lysine	52-58	prolyl 3-hydroxylase family member 4 (non-enzymatic)	Mus musculus	14-18
27394142-1	2017	Transglutaminase 2 (TGase 2) catalyzes a crosslink between protein bound-glutamine and -lysine.	Lysine	88-94	transglutaminase 2	Homo sapiens	20-27
28069522-0	2017	Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.	Lysine	33-39	myeloperoxidase	Homo sapiens	0-15
28011190-4	2017	Herein, we report a dendritic strategy that utilizes the two amine functionalities of lysine to create branch points that allow conjugation of the anticancer drug 5-fluorouracil (5-FU) to the tumor-targeting ligand substance P, along with an additional near-infrared (NIR) squaraine dye, to construct a theranostic dendritic agent, P-FU 4.	Lysine	86-92	tachykinin precursor 1	Homo sapiens	215-226
27660138-3	2017	Results were compared with pretherapeutic Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBEDCC)] (68Ga-PSMA-HBED-CC) PET.	Lysine	55-58	folate hydrolase 1	Homo sapiens	86-90
28185458-3	2017	Two potential ubiquitination sites, lysine residues K556 and K571, of Dur3p were predicted and replaced by arginine, and the effects of these mutations on urea utilization and formation under different nitrogen conditions were investigated.	Lysine	36-42	Dur3p	Saccharomyces cerevisiae S288C	70-75
28442058-7	2017	ChIP revealed an increase in the permissive mark dimethylation of lysine 4 on histone H3 (H3K4me2), surprisingly associated with the silent allele of PHLDA2, and a decrease in the inhibitory mark H3K9me2 in NT samples.	Lysine	66-72	pleckstrin homology like domain family A member 2	Bos taurus	150-156
27869166-4	2017	We observed aberrant upregulation of Skp2, Ezh2 and histone H3 lysine 27 trimethylation (H3K27me3) in both Pten null mouse embryonic fibroblasts (MEFs) and Pten null mouse prostate tissues.	Lysine	63-69	phosphatase and tensin homolog	Mus musculus	107-111
27869166-6	2017	SKP2 knockdown decreased EZH2 levels in human PCa cells through upregulation of TRAF6-mediated and lysine(K) 63-linked ubiquitination of EZH2 for degradation.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	137-141
28122346-6	2017	SETD6 monomethylates NF-kappaB-p65 at lysine 310.	Lysine	38-44	nuclear factor kappa B subunit 1	Homo sapiens	21-30
28069602-3	2017	Here, we identified the lysine-specific demethylase KDM1A as a novel interaction partner of ZEB2 and demonstrated that mouse and human T-ALLs with increased ZEB2 levels critically depend on KDM1A activity for survival.	Lysine	24-30	lysine (K)-specific demethylase 1A	Mus musculus	52-57
28116403-4	2017	Finally, we report on the chemoselective functionalization of bovine serum albumin (BSA) which, owing to the amino group of lysine moieties, reacted with SO2F2 to give a multivalent BSA-SO2F system.	Lysine	124-130	albumin	Homo sapiens	69-82
28053089-8	2017	Furthermore, we identified BD2 as the most critical for PBRM1 and confirmed BD2-mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating the importance of this specific acetylation mark for PBRM1 binding.	Lysine	138-144	defensin beta 4A	Homo sapiens	27-30
28167798-6	2017	The ERalpha-binding sites in tamoxifen-associated endometrial tumors differed from those in the tumors from nonusers and had distinct underlying DNA sequences and divergent enhancer activity as marked by histone 3 containing the acetylated lysine 27 (H3K27ac).	Lysine	240-246	estrogen receptor 1	Homo sapiens	4-11
28073915-0	2017	UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.	Lysine	86-89	ubiquitin conjugating enzyme E2 E1	Homo sapiens	0-6
28073915-0	2017	UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.	Lysine	86-89	ubiquitin conjugating enzyme E2 E1	Homo sapiens	7-12
28073915-3	2017	We demonstrate that UbE2E1 is critical for the monoubiquitination of H2A at residue Lys-119 (uH2AK119) through its association with the PRC1 complex.	Lysine	84-87	ubiquitin conjugating enzyme E2 E1	Homo sapiens	20-26
28053089-8	2017	Furthermore, we identified BD2 as the most critical for PBRM1 and confirmed BD2-mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating the importance of this specific acetylation mark for PBRM1 binding.	Lysine	138-144	defensin beta 4A	Homo sapiens	76-79
28073915-9	2017	This study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys-119 monoubiquitination.	Lysine	134-137	ubiquitin conjugating enzyme E2 E1	Homo sapiens	24-30
28069708-7	2017	Arginine substitution of the ubiquitylated lysine impairs this inactivation mechanism and results in unrestrained FGFR1 ubiquitylation in cells.	Lysine	43-49	fibroblast growth factor receptor 1	Homo sapiens	114-119
28261562-6	2017	This analog inhibits EZH2, a histone methyltransferase that trimethylates lysine 27 histone H3 (H3K27me3), a marker for gene silencing.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	21-25
27913278-4	2017	We hypothesized that the amphipathic properties of the first transmembrane segment (TMS), that contains a positively charged lysine (K25), is a central feature guiding dual targeting.	Lysine	125-131	keratin 25	Homo sapiens	133-136
28104429-0	2017	Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood.	Lysine	6-12	albumin	Homo sapiens	30-43
28337379-6	2017	Mechanistically, RNA immunoprecipitation (RIP) and Chromatin immunoprecipitation (ChIP) verified that LINC00152 bound to Enhancer of zeste homolog 2 (EZH2), LSD1 and histone H3 at lysine 27 (H3K27me3) and epigenetically suppressing P16 expression.	Lysine	180-186	cytoskeleton regulator RNA	Homo sapiens	102-111
28337379-6	2017	Mechanistically, RNA immunoprecipitation (RIP) and Chromatin immunoprecipitation (ChIP) verified that LINC00152 bound to Enhancer of zeste homolog 2 (EZH2), LSD1 and histone H3 at lysine 27 (H3K27me3) and epigenetically suppressing P16 expression.	Lysine	180-186	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	150-154
27913278-6	2017	We also increased the amphipathic character of the helix by inserting an additional lysine either one turn above or below K25.	Lysine	84-90	keratin 25	Homo sapiens	122-125
27913278-12	2017	In contrast, introducing an extra lysine in the first TMS of MGST1 had opposite effects.	Lysine	34-40	microsomal glutathione S-transferase 1	Homo sapiens	61-66
28094437-3	2017	We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC.	Lysine	170-176	PYD and CARD domain containing	Homo sapiens	72-75
27993893-1	2017	Enhancer of zeste homolog-2(EZH2) is a key epigenetic regulator that functions as oncogene and also known for inducing altered trimethylation of histone at lysine-27 (H3K27me3) mark in various tumors.	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27993893-1	2017	Enhancer of zeste homolog-2(EZH2) is a key epigenetic regulator that functions as oncogene and also known for inducing altered trimethylation of histone at lysine-27 (H3K27me3) mark in various tumors.	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
28124276-2	2017	Proteolytic activation of TAFI by thrombin, thrombin in complex with the endothelial cell cofactor thrombomodulin, or plasmin results in an enzyme (TAFIa) that removes carboxyl-terminal lysine residues from protein and peptide substrates, including cell-surface plasminogen receptors.	Lysine	186-192	coagulation factor II, thrombin	Homo sapiens	34-42
28124276-2	2017	Proteolytic activation of TAFI by thrombin, thrombin in complex with the endothelial cell cofactor thrombomodulin, or plasmin results in an enzyme (TAFIa) that removes carboxyl-terminal lysine residues from protein and peptide substrates, including cell-surface plasminogen receptors.	Lysine	186-192	coagulation factor II, thrombin	Homo sapiens	44-52
28094437-3	2017	We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC.	Lysine	170-176	PYD and CARD domain containing	Homo sapiens	209-212
28365758-7	2017	Here we exploited a novel naturally occurring COL17A1 mutation, leading to an in-frame lysine duplication within the coiled-coil structure of the juxtamembranous NC16A domain of collagen XVII, which resulted in a mild phenotype of JEB due to reduced membrane-anchored collagen XVII molecules.	Lysine	87-93	collagen type XVII alpha 1 chain	Homo sapiens	46-53
28161493-8	2017	In this review, we summarize the current basic knowledge on the specific roles of lysine acetyltransferase (KAT) and lysine deacetylase (KDAC) complexes in brain development and the different neurodevelopmental disorders that are associated with dysfunctional lysine (de)acetylation machineries.	Lysine	82-88	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	108-111
28012632-12	2017	Postruminal infusion of Lys resulted in an 86% greater increase in AASS mRNA in the liver compared with mammary mRNA.	Lysine	24-27	aminoadipate-semialdehyde synthase	Bos taurus	67-71
27540894-9	2017	Sirt3-targeted siRNA decreased SOD2 activity by reducing deacetylation of lysine 68 of SOD2, leading to increased osteoclastogenesis.	Lysine	74-80	superoxide dismutase 2, mitochondrial	Mus musculus	31-35
27540894-9	2017	Sirt3-targeted siRNA decreased SOD2 activity by reducing deacetylation of lysine 68 of SOD2, leading to increased osteoclastogenesis.	Lysine	74-80	superoxide dismutase 2, mitochondrial	Mus musculus	87-91
28011933-6	2017	Among histone 3-modifying enzymes, our screen showed that knockdown of the histone 3 lysine 27 (H3K27) methyltransferase and part of the polycomb recessive complex 2, enhancer of Zeste 2, resulted in IRAK-M overexpression.	Lysine	85-91	interleukin 1 receptor associated kinase 3	Homo sapiens	200-206
28012632-1	2017	Lysine supply is potentially limiting for milk production in dairy cows.	Lysine	0-6	Weaning weight-maternal milk	Bos taurus	42-46
28012632-4	2017	This study evaluated the effect of increased postruminal Lys supply on the expression of aminoadipate semialdehyde synthase (AASS, a committing step in Lys catabolism in the liver) and ornithine transcarbamoylase and argininosuccinate synthase (key urea cycle enzymes that are responsive to protein supply).	Lysine	57-60	aminoadipate-semialdehyde synthase	Bos taurus	89-123
28012632-4	2017	This study evaluated the effect of increased postruminal Lys supply on the expression of aminoadipate semialdehyde synthase (AASS, a committing step in Lys catabolism in the liver) and ornithine transcarbamoylase and argininosuccinate synthase (key urea cycle enzymes that are responsive to protein supply).	Lysine	57-60	aminoadipate-semialdehyde synthase	Bos taurus	125-129
28012632-4	2017	This study evaluated the effect of increased postruminal Lys supply on the expression of aminoadipate semialdehyde synthase (AASS, a committing step in Lys catabolism in the liver) and ornithine transcarbamoylase and argininosuccinate synthase (key urea cycle enzymes that are responsive to protein supply).	Lysine	57-60	argininosuccinate synthase 1	Bos taurus	217-243
28012632-9	2017	Milk protein percent increased by 5.9%, plasma Lys increased by 74%, and alpha-aminoadipic acid increased by 51% with postruminal infusion of 63 g/d Lys compared with 0 g/d.	Lysine	149-152	Weaning weight-maternal milk	Bos taurus	0-4
27999085-5	2017	The hypervernalization response is achieved by increased enrichments of VIN3 and trimethylation of Histone H3 Lys 27 at the FLC locus without invoking the increased enrichment of Polycomb Repressive Complex 2.	Lysine	110-113	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	124-127
27581538-8	2017	Pharmacologic inhibition of IDO1 in HSCs by 1-methyltryptophan (1MT) inhibited LPS/HSC-induced AhR signaling in nTregs, which was responsible for their expansion, Foxp3 expression, and stabilization of Foxp3 by increasing acetylation of lysine residues.	Lysine	237-243	toll-like receptor 4	Mus musculus	79-82
27581538-8	2017	Pharmacologic inhibition of IDO1 in HSCs by 1-methyltryptophan (1MT) inhibited LPS/HSC-induced AhR signaling in nTregs, which was responsible for their expansion, Foxp3 expression, and stabilization of Foxp3 by increasing acetylation of lysine residues.	Lysine	237-243	aryl-hydrocarbon receptor	Mus musculus	95-98
27581538-9	2017	Finally, HSCs cryopreserved, following 2-3 passages, were as potent as primary-cultured HSCs in expanding nTregs In conclusion, LPS/HSCs expand allogeneic nTregs through an IDO-dependent, AhR-mediated mechanism and increase their stability through lysine-acetylation of Foxp3.	Lysine	248-254	toll-like receptor 4	Mus musculus	128-131
27590836-6	2017	In the intermediate scenario, IFN-free DAAs for stages F0-F4 had a favorable cost-effectiveness profile vs IFN-based or IFN-free treatment strategies for F2-F4 and offered the greatest return on investment (0.899 LYs gained in SVR and 0.933 QALYs per $10,000 invested).	Lysine	213-216	interferon alpha 1	Homo sapiens	30-33
28188267-8	2017	Importantly, CDKD;2 and SPT5 are required for the deposition of VIP5 and the enhancement of trimethylation of histone 3 lysine 4 in the chromatin of the FLC locus.	Lysine	120-126	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	153-156
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Lysine	76-79	fibrinogen beta chain	Homo sapiens	32-42
28032976-0	2017	Dynamics of Lysine as a Heme Axial Ligand: NMR Analysis of the Chlamydomonas reinhardtii Hemoglobin THB1.	Lysine	12-18	uncharacterized protein	Chlamydomonas reinhardtii	100-104
28032976-3	2017	Unlike pentacoordinate flavohemoglobins, which are efficient NODs, THB1 uses two iron axial ligands: the conserved proximal histidine and a distal lysine (Lys53).	Lysine	147-153	uncharacterized protein	Chlamydomonas reinhardtii	67-71
27993683-3	2017	The lysine residue at 426 (K426) is the acetylation site of NAT10.	Lysine	4-10	N-acetyltransferase 10	Homo sapiens	60-65
28147277-4	2017	Mechanistically, SIRT7 specifically interacts with and deacetylates FKBP51 at residue lysines 28 and 155 (K28 and K155), resulting in enhanced interactions among FKBP51, Akt, and PHLPP, as well as Akt dephosphorylation.	Lysine	86-93	thymoma viral proto-oncogene 1	Mus musculus	170-173
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Lysine	14-21	thymoma viral proto-oncogene 1	Mus musculus	68-71
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Lysine	84-87	fibrinogen beta chain	Homo sapiens	32-42
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Lysine	84-87	fibrinogen beta chain	Homo sapiens	32-42
27989401-0	2017	CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.	Lysine	78-84	CREB binding protein	Homo sapiens	0-3
27890611-1	2017	The histone methyltransferase Setdb1 represses gene expression by catalyzing lysine 9 of histone H3 trimethylation.	Lysine	77-83	SET domain, bifurcated 1	Mus musculus	30-36
27845897-1	2017	The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3.	Lysine	183-189	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	77-81
27789335-1	2017	Lysyl-tRNA synthetase (KRS) is an enzyme that conjugates lysine to its cognate tRNAs in the process of protein synthesis.	Lysine	57-63	lysyl-tRNA synthetase 1	Homo sapiens	0-21
27923618-1	2017	EZH2 (enhancer of zeste homologue 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the methylation of lysine 27 of histone H3 (H3K27).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
27923618-1	2017	EZH2 (enhancer of zeste homologue 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the methylation of lysine 27 of histone H3 (H3K27).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-35
27789335-1	2017	Lysyl-tRNA synthetase (KRS) is an enzyme that conjugates lysine to its cognate tRNAs in the process of protein synthesis.	Lysine	57-63	lysyl-tRNA synthetase 1	Homo sapiens	23-26
27911860-3	2017	Recently, studies have focused on physiological mechanisms such as acetylation of lysine residues to rescue the wild type activity of mutant p53.	Lysine	82-88	tumor protein p53	Homo sapiens	141-144
27992714-2	2017	The catalytic subunit EZH2 methylates primarily lysine 27 of histone H3, leading to chromatin compaction and repression of tumor suppressor genes.	Lysine	48-54	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	peroxisome proliferator activated receptor gamma	Homo sapiens	119-167
27865928-6	2017	Furthermore, we demonstrated that BRM was directly recruited to the cis-regulatory regions of PORC, but not of PORA and PORB, at least partially in a PIF1-dependent manner and the level of histone H3 lysine 4 tri-methylation (H3K4me3) at PORC loci was increased in the brm mutant.	Lysine	200-206	protochlorophyllide oxidoreductase C	Arabidopsis thaliana	94-98
28028228-1	2017	Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in the overreplication of heterochromatin.	Lysine	53-59	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	127-132
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	peroxisome proliferator activated receptor gamma	Homo sapiens	169-178
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	CCAAT enhancer binding protein alpha	Homo sapiens	184-220
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	CCAAT enhancer binding protein alpha	Homo sapiens	222-232
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	peroxisome proliferator activated receptor gamma	Homo sapiens	266-275
28060835-1	2017	Previous studies have shown that tri- or di-methylation of histone H3 at lysine 9 (H3K9me3/me2) on the promoter of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha) contribute to the repression of PPARgamma and C/EBPalpha and inhibition of adipogenesis in 3T3-L1 preadipocytes.	Lysine	73-79	CCAAT enhancer binding protein alpha	Homo sapiens	280-290
28849491-2	2017	Ala, Gln, Gly, Lys, Val and taurine (Tau) are the most abundant free AAs in mammals, and some of these react with hypochlorite (HOCl/OCl-) produced by myeloperoxidase in activated phagocytes to form N-chloroamino acids (NCAA).	Lysine	15-18	occludin	Mus musculus	129-132
28051187-5	2017	MC1 shares structural similarities with the TRAPP complex, but employs a novel mechanism to promote nucleotide exchange that utilizes a conserved lysine residue of Ypt7, which is inserted upon MC1 binding into the nucleotide-binding pocket of Ypt7 and contributes to specificity.	Lysine	146-152	Rab family GTPase YPT7	Saccharomyces cerevisiae S288C	164-168
28051187-5	2017	MC1 shares structural similarities with the TRAPP complex, but employs a novel mechanism to promote nucleotide exchange that utilizes a conserved lysine residue of Ypt7, which is inserted upon MC1 binding into the nucleotide-binding pocket of Ypt7 and contributes to specificity.	Lysine	146-152	Rab family GTPase YPT7	Saccharomyces cerevisiae S288C	243-247
27270439-2	2017	Here we identified that the lysine-specific demethylase KDM3A played a dual role in breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, respectively.	Lysine	28-34	tumor protein p53	Homo sapiens	179-182
27585394-8	2017	CSE treatment of purified CFTR resulted in acrolein modifications on lysine and cysteine residues that likely disrupt CFTR gating.	Lysine	69-75	CF transmembrane conductance regulator	Homo sapiens	26-30
28539967-5	2017	Phosphorylation of Akt and ERK5 (upstream of NFkappaB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively.	Lysine	142-144	AKT serine/threonine kinase 1	Homo sapiens	19-22
27983522-1	2017	OBJECTIVE: UTX and JMJD3 are recently identified histone H3 lysine 27 (H3K27) demethylases.	Lysine	60-66	lysine demethylase 6A	Homo sapiens	11-14
28848139-2	2017	Previous reports showed that several conserved lysine residues within the N-terminal collagenous domain of Apn are modified by hydroxylation and glycosylation.	Lysine	47-53	adiponectin, C1Q and collagen domain containing	Homo sapiens	107-110
27249374-8	2017	RESULTS: In fibrovascular tissues, FDP-Lys staining was found in vascular components containing CD34-positive cells and alpha smooth muscle actin (alpha-SMA)-positive cells, and clusters of rabbit anti-glial fibrillary acid protein (GFAP)-positive cells.	Lysine	39-42	CD34 molecule	Homo sapiens	96-100
28539967-5	2017	Phosphorylation of Akt and ERK5 (upstream of NFkappaB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively.	Lysine	142-144	nuclear factor kappa B subunit 1	Homo sapiens	45-53
28539967-5	2017	Phosphorylation of Akt and ERK5 (upstream of NFkappaB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively.	Lysine	142-144	AKT serine/threonine kinase 1	Homo sapiens	202-205
28049706-0	2017	Coordination of Cell Cycle Progression and Mitotic Spindle Assembly Involves Histone H3 Lysine 4 Methylation by Set1/COMPASS.	Lysine	88-94	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	112-116
28049706-1	2017	Methylation of histone H3 lysine 4 (H3K4) by Set1 complex/COMPASS is a hallmark of eukaryotic chromatin, but it remains poorly understood how this post-translational modification contributes to the regulation of biological processes like the cell cycle.	Lysine	26-32	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	45-49
27798112-6	2017	Specifically, LRRK2 promoted the deacetylation of Lys-5 and Lys-12 on histone H4, causing repression of gene transcription.	Lysine	50-53	leucine rich repeat kinase 2	Homo sapiens	14-19
30196004-0	2017	[Studies on the Interaction of Poly-L-lysine with Fibrinogen with Spectroscopic Methods].	Lysine	31-44	fibrinogen beta chain	Homo sapiens	50-60
30196004-3	2017	Therefore, it is of certain innovation to further evaluate the blood compatibility of poly-L-lysine, which is studied by the interaction between poly-L-lysine and fibrinogen with many spectroscopic methods.	Lysine	86-99	fibrinogen beta chain	Homo sapiens	163-173
30196004-4	2017	In this study, the fluorescence, ultraviolet visible and circular dichroism spectroscopy were used to research the effects of poly-L-lysine on the structure of fibrinogen.	Lysine	126-139	fibrinogen beta chain	Homo sapiens	160-170
30196004-8	2017	Ultraviolet visible spectra showed that the absorption intensity of fibrinogen at 200~240 and 278 nm, which was less affected by 0.025 mg mL(-1) poly-L-lysine, reduced with the concentration of poly-L-lysine increasing.	Lysine	145-158	fibrinogen beta chain	Homo sapiens	68-78
30196004-8	2017	Ultraviolet visible spectra showed that the absorption intensity of fibrinogen at 200~240 and 278 nm, which was less affected by 0.025 mg mL(-1) poly-L-lysine, reduced with the concentration of poly-L-lysine increasing.	Lysine	194-207	fibrinogen beta chain	Homo sapiens	68-78
30196004-9	2017	Circular dichroism spectra showed when the concentration of poly-L-lysine increased, the effect of poly-L-lysine on the secondary structure of fibrinogen strengthened.	Lysine	60-73	fibrinogen beta chain	Homo sapiens	143-153
30196004-9	2017	Circular dichroism spectra showed when the concentration of poly-L-lysine increased, the effect of poly-L-lysine on the secondary structure of fibrinogen strengthened.	Lysine	99-112	fibrinogen beta chain	Homo sapiens	143-153
30196004-10	2017	Overall, as the concentration of poly-L-lysine increased, the alpha-helix content of fibrinogen decreased and the beta-fold, beta-turn and random coil content of fibrinogen increased.	Lysine	33-46	fibrinogen beta chain	Homo sapiens	85-95
30196004-10	2017	Overall, as the concentration of poly-L-lysine increased, the alpha-helix content of fibrinogen decreased and the beta-fold, beta-turn and random coil content of fibrinogen increased.	Lysine	33-46	fibrinogen beta chain	Homo sapiens	162-172
30196004-11	2017	These results showed that the electrostatic interaction was occurred between poly-L-lysine and fibrinogen, which influenced the structure of fibrinogen by concentration dependence.	Lysine	77-90	fibrinogen beta chain	Homo sapiens	95-105
30196004-11	2017	These results showed that the electrostatic interaction was occurred between poly-L-lysine and fibrinogen, which influenced the structure of fibrinogen by concentration dependence.	Lysine	77-90	fibrinogen beta chain	Homo sapiens	141-151
30196004-12	2017	While the effect of poly-L-lysine (0.01 and 0.025 mg mL(-1)) on fibrinogen was little, poly-L-lysine of high concentration would damage the physiological function of fibrinogen.	Lysine	87-100	fibrinogen beta chain	Homo sapiens	166-176
27714956-5	2017	SUMMARY: Background Plg-RKT is a novel integral membrane plasminogen receptor that binds plasminogen via a C-terminal lysine exposed on the cell surface and promotes plasminogen activation on the cell surface by both tissue plasminogen activator and urokinase plasminogen activator.	Lysine	118-124	plasminogen receptor, C-terminal lysine transmembrane protein	Mus musculus	20-27
28002468-4	2016	We identify a cluster of lysines in the MAP2 and MAP4 MTBR that undergo CBP-catalyzed acetylation, many of which are conserved in tau.	Lysine	25-32	CREB binding protein	Homo sapiens	72-75
27798235-6	2017	We report that K5 targets two membrane-proximal VE-cadherin lysine residues for ubiquitination, driving endocytosis and down-regulation of the cadherin.	Lysine	60-66	cadherin 5	Homo sapiens	48-59
27798235-6	2017	We report that K5 targets two membrane-proximal VE-cadherin lysine residues for ubiquitination, driving endocytosis and down-regulation of the cadherin.	Lysine	60-66	cadherin 5	Homo sapiens	51-59
27929168-7	2016	When interacting with 6 Abeta-derived fragments, 3 hexapeptide inhibitors show stronger interactions with two lysine-included fragments (16KLVFFA21 and 27NKGAII33) than other fragments, indicating different sequence-specific interactions with Abeta.	Lysine	110-116	amyloid beta precursor protein	Homo sapiens	24-29
27929168-7	2016	When interacting with 6 Abeta-derived fragments, 3 hexapeptide inhibitors show stronger interactions with two lysine-included fragments (16KLVFFA21 and 27NKGAII33) than other fragments, indicating different sequence-specific interactions with Abeta.	Lysine	110-116	amyloid beta precursor protein	Homo sapiens	243-248
28791052-6	2017	These results correlated with data showing synergism between (1) TSA and BIX01294 in promoting acetylation of lysine 27 on histone H3 and (2) BIX01294 and Wnt11 in decreasing beta-catenin accumulation in MSCs.	Lysine	110-116	Wnt family member 11	Homo sapiens	155-160
27713173-1	2016	BACKGROUND: Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown.	Lysine	117-123	DOT1 like histone lysine methyltransferase	Homo sapiens	12-51
27563817-2	2016	The enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 of histone H3 (H3K27me3) to repress gene transcription.	Lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
27563817-2	2016	The enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 of histone H3 (H3K27me3) to repress gene transcription.	Lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
27713173-1	2016	BACKGROUND: Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown.	Lysine	117-123	DOT1 like histone lysine methyltransferase	Homo sapiens	53-58
27713173-1	2016	BACKGROUND: Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown.	Lysine	117-123	DOT1 like histone lysine methyltransferase	Homo sapiens	245-250
27930340-6	2016	Three lysine residues (K9, K14, and K27) of H3 retained hyperacetylation status in both pwr and hda9 mutants.	Lysine	6-12	histone deacetylase 9	Arabidopsis thaliana	96-100
28066183-0	2016	SOD1 Lysine 123 Acetylation in the Adult Central Nervous System.	Lysine	5-11	superoxide dismutase 1, soluble	Mus musculus	0-4
28066183-3	2016	Reversible acetylation regulates many enzymes and proteomic studies have identified SOD1 acetylation at lysine 123 (K123).	Lysine	104-110	superoxide dismutase 1, soluble	Mus musculus	84-88
27930340-11	2016	We therefore propose that PWR acts as a subunit in a complex with HDA9 to result in lysine deacetylation of histone H3 at specific genomic targets.	Lysine	84-90	histone deacetylase 9	Arabidopsis thaliana	66-70
27990297-5	2016	We show that the mitochondrial stress-induced transcription coactivator hnRNAP2 acetylates Lys 8 of H4 through an intrinsic histone lysine acetyltransferase (KAT) activity with Arg 48 and Arg 50 of hnRNAP2 being essential for acetyl-CoA binding and acetyltransferase activity.	Lysine	91-94	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	158-161
27803162-4	2016	The binding interface was further refined through molecular modeling and mutagenesis and shown to be comprised of complementary charged residues in the NCAM Ig2 domain (Arg-156 and Lys-162) and the EphA3 CRD (Glu-248 and Glu-264).	Lysine	181-184	neural cell adhesion molecule 1	Mus musculus	152-156
27451161-8	2016	Five essential amino acids (leucine, lysine, methionine, threonine, tryptophan) in pasta digesta increased significantly with increasing meat addition.	Lysine	37-43	solute carrier family 45 member 1	Homo sapiens	83-88
27864380-5	2016	SETD5 co-immunoprecipitates with multiple components of the PAF1 and histone deacetylase-containing NCoR complexes and is not solely required for major histone lysine methylation marks.	Lysine	160-166	SET domain containing 5	Homo sapiens	0-5
27829226-6	2016	We found that MAFB could be SUMOylated by SUMO1 at lysine 32, and this modification was critical for cell cycle regulation by MAFB in CRC cells.	Lysine	51-57	small ubiquitin-like modifier 1	Mus musculus	42-47
27836964-5	2016	The lysine-rich motif is required for proper PIN3 phosphorylation and for auxin transport-dependent tropic growth.	Lysine	4-10	Auxin efflux carrier family protein	Arabidopsis thaliana	45-49
27794518-6	2016	Chemical modification studies confirm the requirement for lysine residues in the interaction of fVIII with LRP1.	Lysine	58-64	LDL receptor related protein 1	Homo sapiens	107-111
28357333-4	2016	We report here that Sas2-mediated acetylation of histone H4 at lysine 16 (H4K16ac), one of the Sir2 targets, modulates meiotic checkpoint activity in response to synaptonemal complex defects.	Lysine	63-69	histone acetyltransferase	Saccharomyces cerevisiae S288C	20-24
27845892-7	2016	H19 was further confirmed to suppress the promoter activity of BIK by recruiting EZH2 and by trimethylating the histone H3 at lysine 27.	Lysine	126-132	BCL2 interacting killer	Homo sapiens	63-66
27735058-1	2016	The C-terminal domain (CTD) of tumor suppressor protein p53 is an intrinsically disordered region that binds to various partner proteins, where lysine of CTD is acetylated/nonacetylated and histidine neutralized/non-neutralized.	Lysine	144-150	tumor protein p53	Homo sapiens	56-59
27748806-5	2016	In this study, we found that lncUSMycN upregulated NCYM expression, and knocking-down lncUSMycN reduced histone H3 lysine 4 trimethylation, a marker for active gene transcription, at the NCYM gene promoter.	Lysine	115-121	MYCN upstream transcript	Homo sapiens	86-95
27861797-4	2016	Interestingly, AS-IL6 does not change IL6 mRNA stability, but induces the enrichment of histone H3 acetylated at lysine 27 (H3K27Ac) at the IL6 promoter.	Lysine	113-119	interleukin 6	Homo sapiens	18-21
28042497-3	2016	As the core and contributing catalytic subunit of Polycomb repressive complex 2(PRC2), Enhancer of zeste homolog 2 (EZH2) is a master epigenetic regulator, often serving as a highly conserved histone methyltransferase (HMTase) to induce histone H3 lysine 27 trimethylation (H3K27me3) and repress gene transcription and expression.	Lysine	248-254	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	87-114
28042497-3	2016	As the core and contributing catalytic subunit of Polycomb repressive complex 2(PRC2), Enhancer of zeste homolog 2 (EZH2) is a master epigenetic regulator, often serving as a highly conserved histone methyltransferase (HMTase) to induce histone H3 lysine 27 trimethylation (H3K27me3) and repress gene transcription and expression.	Lysine	248-254	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	116-120
27637923-5	2016	Additionally, ADAM15 efficiently processed Dabcyl-Leu-Arg-Glu-Gln-Gln-Arg-Leu-Lys-Ser-Lys(FAM)-NH2 (PEPDAB022), which is based on a physiological CD23 cleavage site, with a specificity constant (kcat/Km) of 5200 M-1 s-1.	Lysine	78-81	ADAM metallopeptidase domain 15	Homo sapiens	14-20
27637923-5	2016	Additionally, ADAM15 efficiently processed Dabcyl-Leu-Arg-Glu-Gln-Gln-Arg-Leu-Lys-Ser-Lys(FAM)-NH2 (PEPDAB022), which is based on a physiological CD23 cleavage site, with a specificity constant (kcat/Km) of 5200 M-1 s-1.	Lysine	86-89	ADAM metallopeptidase domain 15	Homo sapiens	14-20
27707786-4	2016	Here, we found that loss of several histone-modifying enzymes, including Bre1 (histone H2B ubiquitination) and Set1 (histone H3 lysine 4 methylation), greatly enhanced AICAR inhibition on growth via the combined effects of both the drug and mutations on G1 cyclins.	Lysine	128-134	ring finger protein 20	Homo sapiens	73-77
27707786-4	2016	Here, we found that loss of several histone-modifying enzymes, including Bre1 (histone H2B ubiquitination) and Set1 (histone H3 lysine 4 methylation), greatly enhanced AICAR inhibition on growth via the combined effects of both the drug and mutations on G1 cyclins.	Lysine	128-134	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	111-115
27776770-2	2016	In this study, both lysine and histidine are shown to affect the thermal stability of myoglobin, bovine serum albumin, and lysozyme through a combination of mechanisms governed by their respective functional side chains and glycine, similar to arginine.	Lysine	20-26	albumin	Homo sapiens	104-117
27071708-9	2016	Promoter methylation of several other genes and repressive histone H3 lysine 27 trimethylation by EZH2 of the HIC1 gene may also contribute to parathyroid tumorigenesis.	Lysine	70-76	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	98-102
27776770-2	2016	In this study, both lysine and histidine are shown to affect the thermal stability of myoglobin, bovine serum albumin, and lysozyme through a combination of mechanisms governed by their respective functional side chains and glycine, similar to arginine.	Lysine	20-26	lysozyme	Homo sapiens	123-131
27897169-1	2016	Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression.	Lysine	86-92	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	27-31
27819666-4	2016	The sequence-specific readers recognize both the cis element (termed the cold memory element) and a repressive mark, trimethylation of histone H3 at lysine 27 (H3K27me3), and directly associate with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), leading to establishment of the H3K27me3 peak in the nucleation region at FLC during vernalization.	Lysine	149-155	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	312-315
27806335-6	2016	The N-terminal coiled-coil domain of VP55, containing a single lysine residue, was responsible for the interaction between VP55 and Ubc9 in yeast.	Lysine	63-69	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	132-136
27882937-3	2016	Enhancer of zeste homolog 2 (EZH2) functions as a histone lysine methyltransferase and mediates trimethylation on histone 3 lysine 27 (H3K27me3).	Lysine	58-64	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27882937-3	2016	Enhancer of zeste homolog 2 (EZH2) functions as a histone lysine methyltransferase and mediates trimethylation on histone 3 lysine 27 (H3K27me3).	Lysine	58-64	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27875550-0	2016	An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.	Lysine	105-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	135-139
27814427-1	2016	CREBBP bromodomains, epigenetic "reader" proteins that recognize acetylated histone lysine residues, are a current target for cancer therapy.	Lysine	84-90	CREB binding protein	Homo sapiens	0-6
27720608-4	2016	Importantly, VGLL4 acetylation at lysine 225 negatively regulated its binding to TEAD1.	Lysine	34-40	TEA domain transcription factor 1	Homo sapiens	81-86
27875550-3	2016	For example, small molecule inhibition of the methyltransferase EZH2 reduces global levels of histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	105-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	64-68
27626683-0	2016	SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.	Lysine	15-21	AKT serine/threonine kinase 1	Homo sapiens	81-85
28881723-8	2017	SF1126 inhibits BRD4 bromodomain binding to acetylated lysine residues with histone H3 as well as PI3K activity in the MYCN amplified neuroblastoma cell line IMR-32.	Lysine	55-61	bromodomain containing 4	Homo sapiens	16-20
27647933-4	2016	The HAT CBP/p300, but not GCN5/PCAF, targeted specific lysine residues of the N-terminal homology domain of Pygo2 for acetylation.	Lysine	55-61	CREB binding protein	Homo sapiens	8-16
27647933-4	2016	The HAT CBP/p300, but not GCN5/PCAF, targeted specific lysine residues of the N-terminal homology domain of Pygo2 for acetylation.	Lysine	55-61	pygopus family PHD finger 2	Homo sapiens	108-113
27647933-6	2016	Finally, while acetylation of Pygo2 had little effect on active beta-catenin complex formation, p300-mediated Pygo2 acetylation resulted in the displacement of Pygo2 from the nucleus to the cytoplasm by targeting specific lysine residues in the Pygo2 nuclear localization sequence.	Lysine	222-228	pygopus family PHD finger 2	Homo sapiens	110-115
27647933-6	2016	Finally, while acetylation of Pygo2 had little effect on active beta-catenin complex formation, p300-mediated Pygo2 acetylation resulted in the displacement of Pygo2 from the nucleus to the cytoplasm by targeting specific lysine residues in the Pygo2 nuclear localization sequence.	Lysine	222-228	pygopus family PHD finger 2	Homo sapiens	110-115
27647933-6	2016	Finally, while acetylation of Pygo2 had little effect on active beta-catenin complex formation, p300-mediated Pygo2 acetylation resulted in the displacement of Pygo2 from the nucleus to the cytoplasm by targeting specific lysine residues in the Pygo2 nuclear localization sequence.	Lysine	222-228	pygopus family PHD finger 2	Homo sapiens	110-115
27626683-3	2016	Here we demonstrate that the protein lysine methyltrasnferase SMYD3 methylates lysine 14 in the PH domain of AKT1 both in vitro and in vivo.	Lysine	37-43	AKT serine/threonine kinase 1	Homo sapiens	109-113
27626683-4	2016	Lysine 14-substituted AKT1 shows significantly lower levels of phosphorylation at threonine 308 than wild-type AKT1, and knockdown of SMYD3 as well as treatment with a SMYD3 inhibitor significantly attenuates this phosphorylation in cancer cells.	Lysine	0-6	AKT serine/threonine kinase 1	Homo sapiens	22-26
27626683-5	2016	Furthermore, substitution of lysine 14 diminishes the plasma membrane accumulation of AKT1, and cancer cells overexpressing lysine 14-substiuted AKT1 shows lower growth rate than those overexpressing wild-type AKT1.	Lysine	29-35	AKT serine/threonine kinase 1	Homo sapiens	86-90
27626683-5	2016	Furthermore, substitution of lysine 14 diminishes the plasma membrane accumulation of AKT1, and cancer cells overexpressing lysine 14-substiuted AKT1 shows lower growth rate than those overexpressing wild-type AKT1.	Lysine	29-35	AKT serine/threonine kinase 1	Homo sapiens	145-149
27626683-5	2016	Furthermore, substitution of lysine 14 diminishes the plasma membrane accumulation of AKT1, and cancer cells overexpressing lysine 14-substiuted AKT1 shows lower growth rate than those overexpressing wild-type AKT1.	Lysine	29-35	AKT serine/threonine kinase 1	Homo sapiens	145-149
27845772-7	2016	Mechanistically, LINC00511 bound histone methyltransferase enhancer of zeste homolog 2 ((EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3), and acted as a modular scaffold of EZH2/PRC2 complexes, coordinated their localization, and specified the histone modification pattern on the target genes, including p57, and consequently altered NSCLC cell biology.	Lysine	243-249	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	89-93
27626683-6	2016	These results imply that SMYD3-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation and that SMYD3-mediated AKT1 methylation appears to be a good target for development of anti-cancer therapy.	Lysine	63-69	AKT serine/threonine kinase 1	Homo sapiens	55-59
27626683-6	2016	These results imply that SMYD3-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation and that SMYD3-mediated AKT1 methylation appears to be a good target for development of anti-cancer therapy.	Lysine	63-69	AKT serine/threonine kinase 1	Homo sapiens	90-94
27626683-6	2016	These results imply that SMYD3-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation and that SMYD3-mediated AKT1 methylation appears to be a good target for development of anti-cancer therapy.	Lysine	63-69	AKT serine/threonine kinase 1	Homo sapiens	90-94
27181202-4	2016	We identified that SUMOylation at the lysine 451 site facilitated STAT3 binding to the phosphatase TC45 through an SUMO-interacting motif of TC45.	Lysine	38-44	signal transducer and activator of transcription 3	Homo sapiens	66-71
27833137-4	2016	Moreover, the excessive SUV39h1 also increases tri-methylation of histone H3 on nineth lysine (H3K9me3).	Lysine	87-93	SUV39H1 histone lysine methyltransferase	Homo sapiens	24-31
27819261-5	2016	We show that SIRT1 interacts with the C-terminus of Nkx2.5 and deacetylates Nkx2.5 at lysine 182 in the homeodomain.	Lysine	86-92	NK2 homeobox 5	Homo sapiens	76-82
27109101-2	2016	MMSET overexpression in MM leads to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), as well as changes in proliferation, gene expression and chromatin accessibility.	Lysine	61-67	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
27109101-2	2016	MMSET overexpression in MM leads to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), as well as changes in proliferation, gene expression and chromatin accessibility.	Lysine	125-131	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
27824150-4	2016	Using positional cloning, we revealed that the AtMDN1 function is impaired by a "glutamic acid" to "lysine" change at position 3838 of the amino acid sequence in dsr1.	Lysine	100-106	midasin-like protein	Arabidopsis thaliana	47-53
27819261-6	2016	The mutation of Nkx2.5 at lysine 182 reduces its transcriptional activity.	Lysine	26-32	NK2 homeobox 5	Homo sapiens	16-22
27314403-2	2016	alpha-Tubulin N-acetyltransferase 1 (ATAT1), which acetylates the lysine residue at position 40 of alpha-tubulin, functions not only in stabilizing microtubule structures and forming the primary cilium assembly but also in vesicular trafficking in neurons.	Lysine	66-72	alpha tubulin acetyltransferase 1	Rattus norvegicus	0-35
27378310-1	2016	The lens fiber major intrinsic protein (otherwise known as aquaporin-0 (AQP0), MIP26 and MP26) has been examined by mass spectrometry (MS) in order to determine the speciation of acyl modifications to the side chains of lysine residues and the N-terminal amino group.	Lysine	220-226	major intrinsic protein of lens fiber	Homo sapiens	4-38
27314403-2	2016	alpha-Tubulin N-acetyltransferase 1 (ATAT1), which acetylates the lysine residue at position 40 of alpha-tubulin, functions not only in stabilizing microtubule structures and forming the primary cilium assembly but also in vesicular trafficking in neurons.	Lysine	66-72	alpha tubulin acetyltransferase 1	Rattus norvegicus	37-42
27638352-4	2016	Here, we direct our focus to two primary players in enhancer regulation and their role in cancer pathogenesis: MLL3 and MLL4, members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase.	Lysine	170-176	lysine demethylase 6A	Homo sapiens	241-244
27611768-9	2016	Analysis of the chromatin status of Cdkn1c promoter and KvDMR1 in unresponsive compared to responsive cell types showed that their differential responsiveness to the MyoD-dependent induction of the gene does not involve just their methylation status but, rather, the differential H3 lysine 9 dimethylation at KvDMR1.	Lysine	283-289	myogenic differentiation 1	Homo sapiens	166-170
27611768-0	2016	A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.	Lysine	44-50	cyclin dependent kinase inhibitor 1C	Homo sapiens	114-120
27659526-5	2016	In this study, we show that ARD1 acetylates AR at lysine 618 (K618) in vitro and in vivo.	Lysine	50-56	androgen receptor	Homo sapiens	28-30
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Lysine	18-21	interleukin 1 beta	Mus musculus	118-126
27803188-7	2016	In the absence of defined late-domain motifs, K63-linked polyubiquitinated lysine residues in the HCV NS2 protein bind the HRS ubiquitin-interacting motif to facilitate assembly.	Lysine	75-81	NS2	Homo sapiens	102-105
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Lysine	18-21	tumor necrosis factor	Mus musculus	69-96
27530978-9	2016	In vitro experiments showed that Hcy-thiolactone modifies lysine residues in collagen type I alpha-1 chain.	Lysine	58-64	collagen, type I, alpha 1	Mus musculus	77-100
27534791-5	2016	Further, at specific AtAgo2 loci, both H3K4me3 and histone H3 lysine 9 acetylation (H3K9ac) are important in controlling gene expression in response to gamma irradiation.	Lysine	62-68	Argonaute family protein	Arabidopsis thaliana	21-27
27792935-2	2016	Tissue transglutaminase (TG2), a Ca2+-dependent enzyme, is secreted by PDA cells and cross-links proteins in the tumor microenvironment (TME) through acyl-transfer between glutamine and lysine residues, promoting PDA growth.	Lysine	186-192	transglutaminase 2	Homo sapiens	0-23
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Lysine	33-39	androgen receptor	Homo sapiens	3-5
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Lysine	33-39	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Lysine	33-39	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Lysine	33-39	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Lysine	33-39	androgen receptor	Homo sapiens	66-68
27573245-5	2016	We identified three ubiquitylated lysine residues and showed that DNA ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cul4-DDB1 complex.	Lysine	34-40	DDB1 and CUL4 associated factor 7	Homo sapiens	132-137
27798683-0	2016	Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.	Lysine	18-24	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	42-48
27798683-0	2016	Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.	Lysine	84-90	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	42-48
27798683-2	2016	SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase that regulates the methylation of histone H3 on lysine 9 (H3K9), gene silencing, and transcriptional repression.	Lysine	113-119	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	26-32
27798683-6	2016	We also demonstrate that the ubiquitination of lysine 867 of the human SETDB1 is necessary for full H3K9 methyltransferase activity in mammalian cells.	Lysine	47-53	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	71-77
27798683-8	2016	These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.	Lysine	59-65	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	49-55
27791979-2	2016	Using quantitative thermodynamic, kinetic and structural methods, we show that synaptotagmin-1 (from Rattus norvegicus and expressed in Escherichia coli) binds to PtdIns(4,5)P2 via a polybasic lysine patch in the C2B domain, which may promote the priming or docking of synaptic vesicles.	Lysine	193-199	synaptotagmin 1	Rattus norvegicus	79-94
27638307-1	2016	Enhancer of Zeste Homolog 2(EZH2), which can change chromatin structure by tri-methylation of the 27th lysine of H3 in nucleosome histone (H3K27me3), is involved in different types of cancers.	Lysine	103-109	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27638307-1	2016	Enhancer of Zeste Homolog 2(EZH2), which can change chromatin structure by tri-methylation of the 27th lysine of H3 in nucleosome histone (H3K27me3), is involved in different types of cancers.	Lysine	103-109	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
27764181-1	2016	Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3).	Lysine	181-187	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-28
27764181-1	2016	Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3).	Lysine	181-187	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
27573245-6	2016	Notably, knockdown of DCAF7 reduced the degradation of DNA ligase I in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I by Cul4-DDB1 and DCAF7.	Lysine	144-150	DDB1 and CUL4 associated factor 7	Homo sapiens	22-27
27569044-2	2016	In humans, attachment of ubiquitin to lysine 120 of histone H2B depends on the activity of the E2 ubiquitin-conjugating enzyme, Ube2B, and the really interesting new gene (RING) E3 ligases, RING finger protein (RNF) 20 and RNF40.	Lysine	38-44	ring finger protein 20	Homo sapiens	190-218
27582494-3	2016	Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 binding motif of 2 lysine residues separated by about 21 A and mutated the candidate lysine residues to alanine individually and in pairs.	Lysine	146-152	LDL receptor related protein 1	Homo sapiens	95-99
27582494-3	2016	Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 binding motif of 2 lysine residues separated by about 21 A and mutated the candidate lysine residues to alanine individually and in pairs.	Lysine	146-152	LDL receptor related protein 1	Homo sapiens	122-126
27582494-3	2016	Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 binding motif of 2 lysine residues separated by about 21 A and mutated the candidate lysine residues to alanine individually and in pairs.	Lysine	212-218	LDL receptor related protein 1	Homo sapiens	95-99
27587397-3	2016	Using a combination of studies we now show EPO uses plasma levels of the pseudohalide thiocyanate (SCN-) as substrate to catalyze protein carbamylation, as monitored by PTM of protein lysine residues into Nepsilon-carbamyllysine (homocitrulline), and contributes to the pathophysiological sequelae of eosinophil activation.	Lysine	184-190	eosinophil peroxidase	Mus musculus	43-46
27790619-3	2016	Recent evidence demonstrated that the mitochondrial NAD+-dependent deacetylase sirtuin 3 (SIRT3) may regulate these mitochondrial functions by reversible protein lysine deacetylation.	Lysine	162-168	sirtuin 3	Homo sapiens	90-95
27569044-2	2016	In humans, attachment of ubiquitin to lysine 120 of histone H2B depends on the activity of the E2 ubiquitin-conjugating enzyme, Ube2B, and the really interesting new gene (RING) E3 ligases, RING finger protein (RNF) 20 and RNF40.	Lysine	38-44	ring finger protein 40	Homo sapiens	223-228
27480105-5	2016	SMYD2 methylates lysine-8 (K8) within a -(8)KSKK(11)- motif embedded in the GFI1 SNAG domain.	Lysine	17-23	growth factor independent 1A transcription repressor b	Danio rerio	76-80
27705745-4	2016	In mouse embryonic stem cells, RYBP plays a central role in shaping H2AK119 mono-ubiquitylation at PcG targets and underpins an activity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required for normal histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	251-257	protein regulator of cytokinesis 1	Mus musculus	165-169
27666593-4	2016	The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414.	Lysine	131-137	interferon alpha 1	Homo sapiens	34-37
27480107-2	2016	Asymmetric dimethylation of histone H3R2 by PRMT6 acts as a repressive mark that antagonizes trimethylation of H3 lysine 4 by the MLL histone H3K4 methyltransferase.	Lysine	114-120	protein arginine methyltransferase 6	Homo sapiens	44-49
27177020-4	2016	The major SUMO-attachment site, lysine 422, is required for FKBP51-mediated inhibition of GR activity in hippocampal neuronal cells.	Lysine	32-38	nuclear receptor subfamily 3 group C member 1	Homo sapiens	90-92
27470549-1	2016	In this study, transferrin (Tf)-conjugated polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) (PEG-PLL-PLGA)-based micellar formulations were successfully prepared for the delivery of edelfosine (EDS) in leukemia treatment.	Lysine	69-82	transferrin	Homo sapiens	15-26
27470549-1	2016	In this study, transferrin (Tf)-conjugated polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) (PEG-PLL-PLGA)-based micellar formulations were successfully prepared for the delivery of edelfosine (EDS) in leukemia treatment.	Lysine	69-82	transferrin	Homo sapiens	28-30
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	ubiquitin specific peptidase 4	Homo sapiens	24-54
27443248-4	2016	In this study, we identified that the C terminus of Hsc70-interacting protein (CHIP) interacted with CLEC-2 by mass spectrometry analysis, and CHIP decreased the protein expression of CLEC-2 through lysine-48-linked ubiquitination and proteasomal degradation.	Lysine	199-205	ST13 Hsp70 interacting protein	Homo sapiens	52-77
27443248-4	2016	In this study, we identified that the C terminus of Hsc70-interacting protein (CHIP) interacted with CLEC-2 by mass spectrometry analysis, and CHIP decreased the protein expression of CLEC-2 through lysine-48-linked ubiquitination and proteasomal degradation.	Lysine	199-205	C-type lectin domain family 1 member B	Homo sapiens	184-190
27790061-2	2016	Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), thereby inhibiting the phosphorylation of FAK at tyrosine (Y) 397 residue (pY397-FAK), which is a marker of its activation.	Lysine	116-119	leucine rich repeat kinase 2	Homo sapiens	27-32
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	ubiquitin specific peptidase 4	Homo sapiens	56-60
27650334-2	2016	Polycomb Repressive Complex 2 (PRC2) catalyzes the trimethylation of Histone 3 at lysine 27 (H3K27me3), which is the hallmark of a repressive chromatin state.	Lysine	82-88	proteasome core particle subunit alpha 1	Saccharomyces cerevisiae S288C	31-35
27267320-11	2016	Furthermore, RNA and chromatin immunoprecipitation assays demonstrated that lncRNA-UNMIBC was physically associated with EZH2 and SUZ12, leading to an altered histone H3 lysine 27 methylation status of target genes.	Lysine	170-176	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-125
27007123-1	2016	Brd4 is an epigenetic reader protein and a member of the BET (bromodomain and extra terminal domain) family of proteins with two bromodomains that recognize acetylated lysine residues.	Lysine	168-174	bromodomain containing 4	Homo sapiens	0-4
27007123-3	2016	Polyomavirus JC (JCV) is regulated by a noncoding control region (NCCR) containing promoter/enhancer elements for viral gene expression including a binding site for NF-kappaB, which responds to proinflammatory cytokines such as TNF-alpha, the DNA damage response, calcium signaling and acetylation of the NF-kappaB p65 subunit on lysine residues K218 and K221.	Lysine	330-336	nuclear factor kappa B subunit 1	Homo sapiens	165-174
27749582-6	2016	DNA sequencing of NFKB2 identified a heterozygous nonsense mutation (c.2563 A&gt;T, p.855: Lys&gt;*) in the patient but not her parents.	Lysine	91-94	nuclear factor kappa B subunit 2	Homo sapiens	18-23
27358110-3	2016	Here, deacetylation of the Stat5a coactivator and chromatin-remodeling protein HMGN2 on lysine residue K2 by HDAC6 promotes Stat5a-mediated transcription and breast cancer growth.	Lysine	88-94	histone deacetylase 6	Homo sapiens	109-114
27528606-6	2016	However, Imp5, Imp7, Imp9, and Impalpha bind two separate elements in the H3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.	Lysine	131-137	importin 7	Homo sapiens	15-19
27528606-8	2016	Of the many lysine residues in the H3 and H4 tails, only acetylation of the H3 Lys14 substantially decreased binding to several Importins.	Lysine	12-18	H3 clustered histone 14	Homo sapiens	35-44
27688818-2	2016	Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated.	Lysine	0-6	tumor protein p53	Homo sapiens	96-99
27566578-7	2016	Mechanistically, HoxA-AS3 interacts with Enhancer Of Zeste 2 (EZH2) and is required for H3 lysine-27 trimethylation (H3K27me3) of key osteogenic transcription factor Runx2.	Lysine	91-97	HOXA cluster antisense RNA 3	Homo sapiens	17-25
26973248-5	2016	Polyubiquitination of the conserved lysine 60 of IER3 is essential for its degradation.	Lysine	36-42	immediate early response 3	Homo sapiens	49-53
27661449-3	2016	This function of Pask is dependent upon its ability to phosphorylate Wdr5, a member of several protein complexes including those that catalyze histone H3 Lysine 4 trimethylation (H3K4me3) during transcriptional activation.	Lysine	154-160	WD repeat domain 5	Homo sapiens	69-73
27511731-1	2016	ESET/SETDB1, one of the major histone methyltransferases, catalyzes histone 3 lysine 9 (H3K9) trimethylation.	Lysine	78-84	SET domain, bifurcated 1	Mus musculus	0-4
27695348-8	2016	Mechanistic studies revealed that HOTAIR modified the promoter of p53 and enhanced histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	94-100	tumor protein p53	Homo sapiens	66-69
27653678-0	2016	IFN-gamma Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.	Lysine	28-34	interferon gamma	Homo sapiens	0-9
27653678-3	2016	By using transcriptomic and epigenomic analysis, we found that stable repression of a small group of genes by IFN-gamma is associated with recruitment of the histone methyltransferase EZH2 and deposition of the negative mark histone 3 lysine 27 trimethylation (H3K27me3) at their promoters.	Lysine	235-241	interferon gamma	Homo sapiens	110-119
27601672-3	2016	How this single lysine residue on the nucleosome core particle (NCP) is targeted by the Rad6-Bre1 machinery is unknown.	Lysine	16-22	ring finger protein 20	Homo sapiens	93-97
27475536-4	2016	Four lysine residues, K(297), K(301), K(303), and K(334), are known to be required for Vif-mediated A3G ubiquitination and degradation.	Lysine	5-11	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	100-103
27511731-1	2016	ESET/SETDB1, one of the major histone methyltransferases, catalyzes histone 3 lysine 9 (H3K9) trimethylation.	Lysine	78-84	SET domain, bifurcated 1	Mus musculus	5-11
27449519-5	2016	Because noncoding transcription can lead to changes in the local chromatin landscape that impinge on the expression of nearby coding genes, we surveyed the effects of various chromatin regulators on the expression of ECM3 These analyses identified roles for the Paf1 complex in positively regulating ECM3 transcription through methylation of histone H3 at lysine 4 (K4) and for Paf1 in controlling the pattern of intergenic transcription at this locus.	Lysine	356-362	Paf1p	Saccharomyces cerevisiae S288C	262-266
27713965-0	2016	Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27.	Lysine	135-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-83
27713965-4	2016	RS4-fed mice, compared to the control-diet group, had higher cecal butyrate and increased tri-methylation of lysine 27 on histone 3 (H3K27me3) in the promoter of nuclear factor-kappa-B1 (NFkappaB1) in the colon tissue.	Lysine	109-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-185
27470585-7	2016	Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin.	Lysine	223-236	mitogen-activated protein kinase 3	Homo sapiens	141-146
27470585-7	2016	Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin.	Lysine	223-236	insulin	Homo sapiens	356-363
27590064-7	2016	Lys(181) located in the Exo70A1 hypervariable region may be the ubiquitination site mediating the interaction between ARC1 and Exo70A1.	Lysine	0-3	U-box domain-containing protein 17-like	Brassica oleracea	118-122
27605430-5	2016	We present several new X-ray crystal structures of both human Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues.	Lysine	184-190	ras homolog family member T1	Homo sapiens	62-67
27605430-5	2016	We present several new X-ray crystal structures of both human Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues.	Lysine	184-190	ras homolog family member T2	Homo sapiens	72-77
27605430-7	2016	Finally, we show that prioritization for modification of a specific lysine sidechain of the cGTPase (K572) within human Miro1 is dependent on both its location and chemical microenvironment.	Lysine	68-74	ras homolog family member T1	Homo sapiens	120-125
26855179-0	2016	Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.	Lysine	15-21	nuclear receptor subfamily 1 group I member 2	Homo sapiens	36-55
27470515-7	2016	Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells.	Lysine	10-16	S100 calcium binding protein B	Homo sapiens	50-53
27470515-7	2016	Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells.	Lysine	10-16	S100 calcium binding protein B	Homo sapiens	78-81
27470515-7	2016	Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells.	Lysine	10-16	S100 calcium binding protein B	Homo sapiens	78-81
26855179-7	2016	Through LC-MS/MS analysis, we identified lysine 109 (K109) in the hinge as PXR"s major acetylation site.	Lysine	41-47	nuclear receptor subfamily 1 group I member 2	Homo sapiens	75-78
26883953-6	2016	Using both primary cultures of hepatocytes and cell-based assays, we show here that PXR is modified through acetylation on lysine residues.	Lysine	123-129	nuclear receptor subfamily 1 group I member 2	Homo sapiens	84-87
27380180-2	2016	Following the conversion of a lysine residue on eIF5A to deoxyhypusine (Dhp) by deoxyhypusine synthase, hDOHH hydroxylates Dhp to yield the unusual amino acid residue hypusine (Hpu), a modification that is essential for eIF5A to promote peptide synthesis at the ribosome, among other functions.	Lysine	30-36	deoxyhypusine synthase	Homo sapiens	80-102
26883953-8	2016	Pharmacologic inhibition of lysine de-acetylation using trichostatin A (TSA) alters the sub-cellular localization of PXR in cultured hepatocytes, and also has a profound impact upon PXR transactivation capacity.	Lysine	28-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	117-120
26883953-8	2016	Pharmacologic inhibition of lysine de-acetylation using trichostatin A (TSA) alters the sub-cellular localization of PXR in cultured hepatocytes, and also has a profound impact upon PXR transactivation capacity.	Lysine	28-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	182-185
26728620-3	2016	An example of this is DOT1L, the enzyme that can mono-, di-, and trimethylate the nucleosome core on lysine 79 of histone H3 (H3K79).	Lysine	101-107	DOT1 like histone lysine methyltransferase	Homo sapiens	22-27
27341472-6	2016	Further, the histone H3 in this region was distinctly acetylated or trimethylated on lysine 9 in a cell cycle-dependent fluctuation pattern: H3K9ac was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication.	Lysine	85-91	DBF4 zinc finger	Homo sapiens	176-180
27843805-7	2016	Lysine residues K281 (TRalpha) and K50 (TRbeta) are isoform-specific SUMOylation sites influencing differing TR domains, whereas K387 (TRalpha) and K443 (TRbeta) are orthologous residues.	Lysine	0-6	T cell receptor beta locus	Homo sapiens	40-46
27843805-7	2016	Lysine residues K281 (TRalpha) and K50 (TRbeta) are isoform-specific SUMOylation sites influencing differing TR domains, whereas K387 (TRalpha) and K443 (TRbeta) are orthologous residues.	Lysine	0-6	T cell receptor beta locus	Homo sapiens	154-160
27618414-9	2016	Diabetes-induced FDP-lysine accumulation in Muller glia was associated with a reduction in ALDH1a1 mRNA and protein expression in whole retina and a decrease in ALDH1a1-immunoreactivity specifically within these cells.	Lysine	21-27	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	91-98
27618414-9	2016	Diabetes-induced FDP-lysine accumulation in Muller glia was associated with a reduction in ALDH1a1 mRNA and protein expression in whole retina and a decrease in ALDH1a1-immunoreactivity specifically within these cells.	Lysine	21-27	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	161-168
27618414-11	2016	Activity of ALDH was suppressed in the diabetic retina and blockade of ALDH1a1 in cultured Muller glia triggered FDP-lysine accumulation and reduced cell viability.	Lysine	117-123	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	71-78
27380996-3	2016	Aberrant lysine acetylation mediated by CBP/p300 has recently been implicated in the genesis of multiple hematologic cancers.	Lysine	9-15	CREB binding protein	Homo sapiens	40-43
25677829-0	2016	Leucine and lysine intakes are highly associated with serum adiponectin levels in asymptomatic adults.	Lysine	12-18	adiponectin, C1Q and collagen domain containing	Homo sapiens	60-71
25677829-6	2016	RESULTS: A positive correlation between the ratio of leucine:lysine intake and adiponectin and a negative correlation between adiponectin and presence of already two components of MetS were found.	Lysine	61-67	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90
27550047-1	2016	BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3).	Lysine	273-279	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	210-214
27494834-2	2016	EZH2, a histone methyltransferase, promotes cell growth and migration through catalyzing trimethylation of histone H3 at Lys 27 (H3K27me3) and plays an important role in tumorigenesis.	Lysine	121-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
27119313-7	2016	We identified a new and de novo 1q21.3 deletion that encompasses SETDB1, a gene encoding methylates histone H3 on lysine-9 (H3K9) methyltransferase, in a case with ASD.	Lysine	114-120	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	65-71
27535933-0	2016	Lysine methylation represses p53 activity in teratocarcinoma cancer cells.	Lysine	0-6	tumor protein p53	Homo sapiens	29-32
27535933-3	2016	Here we report that in the teratocarcinoma cell line NTera2, p53 is subject to lysine methylation at its carboxyl terminus, which has been shown to repress p53"s transcriptional activity.	Lysine	79-85	tumor protein p53	Homo sapiens	61-64
27535933-3	2016	Here we report that in the teratocarcinoma cell line NTera2, p53 is subject to lysine methylation at its carboxyl terminus, which has been shown to repress p53"s transcriptional activity.	Lysine	79-85	tumor protein p53	Homo sapiens	156-159
27535933-6	2016	Our results provide evidence that lysine methylation of endogenous wild-type p53 represses its activity in cancer cells and suggest new therapeutic possibilities of targeting testicular teratocarcinoma.	Lysine	34-40	tumor protein p53	Homo sapiens	77-80
27179746-2	2016	The histone methyltransferase EZH2 is the catalytic subunit of PRC2, a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3.	Lysine	150-156	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
27582065-2	2016	Enhancer of zeste homolog 2 (EZH2) is the catalytic component of a multiprotein complex, polycomb repressive complex 2, which is involved in the trimethylation of histone H3 at lysine 27.	Lysine	177-183	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27582065-2	2016	Enhancer of zeste homolog 2 (EZH2) is the catalytic component of a multiprotein complex, polycomb repressive complex 2, which is involved in the trimethylation of histone H3 at lysine 27.	Lysine	177-183	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27581177-2	2016	Basic amino acids improved insulin solubility in water while 200 and 400 mug/mL lysine significantly increased insulin solubility in HBSS.	Lysine	80-86	insulin	Homo sapiens	111-118
27581177-3	2016	Permeability data showed a significant improvement in insulin permeation especially for 10 mug/mL of lysine (p &lt; 0.05) and 10 mug/mL histidine (p &lt; 0.001), 100 mug/mL of glutamic acid (p &lt; 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p &lt; 0.001) without affecting cell integrity; in contrast to sodium deoxycholate which enhanced insulin permeability but was toxic to the cells.	Lysine	101-107	insulin	Homo sapiens	54-61
27524613-5	2016	SNP rs539846 C&gt;A, the most highly associated variant (p = 1.42 x 10(-13), odds ratio = 1.35), localizes to a super-enhancer defined by extensive histone H3 lysine 27 acetylation in intron 3 of B cell lymphoma 2 (BCL2)-modifying factor (BMF).	Lysine	159-165	BCL2 apoptosis regulator	Homo sapiens	196-213
27402839-5	2016	Studies on the interaction of the RAP third domain with LRP1 reveal critical contributions by lysine 256 and lysine 270 for this interaction.	Lysine	109-115	LDL receptor related protein 1	Homo sapiens	56-60
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	133-139	LDL receptor related protein 1	Homo sapiens	54-58
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	133-139	LDL receptor related protein 1	Homo sapiens	184-188
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	133-139	LDL receptor related protein 1	Homo sapiens	184-188
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	153-159	LDL receptor related protein 1	Homo sapiens	54-58
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	153-159	LDL receptor related protein 1	Homo sapiens	184-188
27402839-8	2016	Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex.	Lysine	153-159	LDL receptor related protein 1	Homo sapiens	184-188
27402839-9	2016	When lysine 60 and 191 are both mutated to alanine, the binding of D1D2 to LRP1 is ablated.	Lysine	5-11	LDL receptor related protein 1	Homo sapiens	75-79
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Lysine	99-102	epidermal growth factor receptor	Homo sapiens	18-22
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Lysine	182-185	epidermal growth factor receptor	Homo sapiens	18-22
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Lysine	182-185	epidermal growth factor receptor	Homo sapiens	18-22
27297094-6	2016	Inhibition of ubiquitin-activating enzyme E1 by PYR-41 or blocking the formation of ubiquitin chains by over-expressing the lysine to arginine mutation of ubiquitin K48 (K48R) inhibited A3G degradation.	Lysine	124-130	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	186-189
27297094-9	2016	Notably, A3G degradation relied on the lysine residues involved in polyubiquitination.	Lysine	39-45	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	9-12
27402839-0	2016	High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.	Lysine	190-197	LDL receptor related protein 1	Homo sapiens	129-133
27402839-5	2016	Studies on the interaction of the RAP third domain with LRP1 reveal critical contributions by lysine 256 and lysine 270 for this interaction.	Lysine	94-100	LDL receptor related protein 1	Homo sapiens	56-60
27468126-1	2016	EZH2 or EZH1 (enhancer of zeste homologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
27468126-1	2016	EZH2 or EZH1 (enhancer of zeste homologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	14-43
27524613-5	2016	SNP rs539846 C&gt;A, the most highly associated variant (p = 1.42 x 10(-13), odds ratio = 1.35), localizes to a super-enhancer defined by extensive histone H3 lysine 27 acetylation in intron 3 of B cell lymphoma 2 (BCL2)-modifying factor (BMF).	Lysine	159-165	BCL2 apoptosis regulator	Homo sapiens	215-219
27579368-2	2016	Targeting of HP1 proteins to specific chromatin locales is mediated, at least in part, by the HP1 chromodomain, which binds to histone H3 methylated at lysine 9 that marks condensed regions of the genome.	Lysine	152-158	Suppressor of variegation 205	Drosophila melanogaster	13-16
27579368-2	2016	Targeting of HP1 proteins to specific chromatin locales is mediated, at least in part, by the HP1 chromodomain, which binds to histone H3 methylated at lysine 9 that marks condensed regions of the genome.	Lysine	152-158	Suppressor of variegation 205	Drosophila melanogaster	94-97
27579368-6	2016	These findings help elucidate important functional roles of reversible posttranslational modifications of proteins in the HP1 family, in this case, regulating the targeting of a ciliate HP1 to chromatin regions marked with methylated H3 lysine 27.	Lysine	237-243	Suppressor of variegation 205	Drosophila melanogaster	122-125
27325702-6	2016	In vitro ubiquitination/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the ACR residues Lys(649/650/651/676/688) Deletion of Crbn reduces ubiquitination of Lys(676) suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro ubiquitination of presynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter release.	Lysine	135-138	cereblon	Homo sapiens	172-176
27579368-6	2016	These findings help elucidate important functional roles of reversible posttranslational modifications of proteins in the HP1 family, in this case, regulating the targeting of a ciliate HP1 to chromatin regions marked with methylated H3 lysine 27.	Lysine	237-243	Suppressor of variegation 205	Drosophila melanogaster	186-189
27563873-8	2016	In complementary ubiquitination assays, we show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain.	Lysine	109-115	tribbles pseudokinase 2	Homo sapiens	53-58
27563873-8	2016	In complementary ubiquitination assays, we show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain.	Lysine	109-115	tribbles pseudokinase 2	Homo sapiens	166-171
27297111-0	2016	Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.	Lysine	0-7	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	25-33
27297111-7	2016	We report that DNA-PKcs is acetylated in vivo and identified two putative acetylation sites, lysine residues 3241 and 3260.	Lysine	93-99	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	15-23
27335278-3	2016	We observed that murine hematopoietic stem cells (HSCs) in which Dnmt3a had been conditionally deleted markedly overexpress the histone 3 lysine 79 (H3K79) methyltransferase, Dot1l.	Lysine	138-144	DNA methyltransferase 3A	Mus musculus	65-71
27325695-5	2016	Point mutations identified two amino acids (Lys-98 and Asp-100 in LRRC8A and equivalent residues in LRRC8C and -E), which upon charge reversal strongly altered the kinetics and voltage dependence of inactivation.	Lysine	44-47	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	66-72
27325702-6	2016	In vitro ubiquitination/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the ACR residues Lys(649/650/651/676/688) Deletion of Crbn reduces ubiquitination of Lys(676) suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro ubiquitination of presynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter release.	Lysine	135-138	cereblon	Homo sapiens	278-282
27325702-6	2016	In vitro ubiquitination/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the ACR residues Lys(649/650/651/676/688) Deletion of Crbn reduces ubiquitination of Lys(676) suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro ubiquitination of presynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter release.	Lysine	203-206	cereblon	Homo sapiens	172-176
27325702-6	2016	In vitro ubiquitination/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the ACR residues Lys(649/650/651/676/688) Deletion of Crbn reduces ubiquitination of Lys(676) suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro ubiquitination of presynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter release.	Lysine	203-206	cereblon	Homo sapiens	172-176
27240956-4	2016	Under basal conditions CF cells had increased bromodomain (Brd)3 and Brd4 recruitment and enhanced NF-kappaB and C/EBPbeta binding to the CXCL8 promoter compared to non-CF cells due to trimethylation of histone H3 at lysine 4 (H3K4me3) and DNA hypomethylation at CpG6.	Lysine	217-223	C-X-C motif chemokine ligand 8	Homo sapiens	138-143
27507649-8	2016	Blockade of interleukin-6 (IL-6)-JAK-STAT signaling, NF-kappaB signaling, and bromodomain extraterminal proteins, which recognize acetylated lysines and promote transcriptional elongation, significantly reduced Il-6 and Mmp13 expression in HDAC3-deficient chondrocytes and secondary activation in osteoclasts.	Lysine	141-148	interleukin 6	Mus musculus	12-25
27507649-8	2016	Blockade of interleukin-6 (IL-6)-JAK-STAT signaling, NF-kappaB signaling, and bromodomain extraterminal proteins, which recognize acetylated lysines and promote transcriptional elongation, significantly reduced Il-6 and Mmp13 expression in HDAC3-deficient chondrocytes and secondary activation in osteoclasts.	Lysine	141-148	interleukin 6	Mus musculus	27-31
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	SUMO specific peptidase 1	Homo sapiens	28-33
27477386-7	2016	Within this segment, we identified a cluster of three lysine residues that contribute to the microtubule bundling activity of HsCEP135-N. Our results provide the first structural information on CEP135/Bld10p proteins and offer insights into their microtubule-binding mechanism.	Lysine	54-60	centrosomal protein 135	Homo sapiens	128-134
27487295-2	2016	In this report, fructated apoA-I (fA-I) induced by fructose treatment showed a covalently multimerized band without cross-linking, and lysine residues were irreversibly modified to prevent crosslinking.	Lysine	135-141	apolipoprotein A1	Homo sapiens	26-32
27217481-9	2016	MBD1 then interacts with SET domain bifurcated 1 methyltransferase to promote bimethylation on the histone 3 lysine 9 residue, reducing Pomc mRNA expression.	Lysine	109-115	methyl-CpG binding domain protein 1	Homo sapiens	0-4
27371876-9	2016	This review focuses on the role of HDAC 3 in (NF-kappaB-mediated) inflammation and NF-kappaB lysine acetylation.	Lysine	93-99	nuclear factor kappa B subunit 1	Homo sapiens	83-92
27289322-1	2016	Chirally pure R- and S-epimers of TLR2 ligand Pam3CysSK4 were prepared and separately conjugated to an OVA model epitope, in which lysine was replaced by azidonorleucine.	Lysine	131-137	toll like receptor 2	Homo sapiens	34-38
27217481-9	2016	MBD1 then interacts with SET domain bifurcated 1 methyltransferase to promote bimethylation on the histone 3 lysine 9 residue, reducing Pomc mRNA expression.	Lysine	109-115	proopiomelanocortin	Homo sapiens	136-140
26847429-7	2016	Treatment with a low-lysine dietary regimen and carnitine supplementation was started and resulted in an improvement in metabolic control and a reduction of hypoglycemic episodes along with an increasing in insulin daily dose.	Lysine	21-27	insulin	Homo sapiens	207-214
26983943-0	2016	Pyruvate kinase deletion as an effective phenotype to enhance lysine production in Corynebacterium glutamicum ATCC13032: Redirecting the carbon flow to a precursor metabolite.	Lysine	62-68	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	0-15
27280692-2	2016	In Caenorhabditis elegans, MSCI is mediated by MET-2 methyltransferase deposition of histone H3 lysine 9 dimethylation.	Lysine	96-102	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	47-52
27280692-7	2016	Further, both histone H3 lysine 9 di- and trimethylation were reduced in Cbr-met-2 mutant germ lines, suggesting that in contrast to C. elegans, H3 lysine 9 di- and trimethylation are interdependent.	Lysine	25-31	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	77-82
27280692-7	2016	Further, both histone H3 lysine 9 di- and trimethylation were reduced in Cbr-met-2 mutant germ lines, suggesting that in contrast to C. elegans, H3 lysine 9 di- and trimethylation are interdependent.	Lysine	148-154	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	77-82
27278257-4	2016	EZH2 impairs gene expression by catalyzing the tri-methylation of histone H3 lysine 27 (H3K27me3) which controls gene transcription epigenetically.	Lysine	77-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Lysine	135-141	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	0-15
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Lysine	135-141	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	17-20
26983943-6	2016	Under these conditions, while the simple mutant D2 with pyk deletion or R2 with the PEPC-desensitization mutation showed marginally increased lysine yield (~1.1-fold, not significant), the mutant DR2 strain having both mutations showed synergistically increased lysine productivity (1.38-fold, 12.9 g/L).	Lysine	142-148	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	84-88
27311481-1	2016	Deacetylation of alpha-tubulin at lysine 40 is catalyzed by two enzymes, the NAD-dependent deacetylase SIRT2 and the NAD-independent deacetylase HDAC6, in apparently redundant reactions.	Lysine	34-40	histone deacetylase 6	Homo sapiens	145-150
27268279-5	2016	We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells.	Lysine	21-27	WD repeat domain 5	Homo sapiens	220-224
27374983-0	2016	Lysine acetylation stabilizes SP2 protein in the silkworm Bombyx mori.	Lysine	0-6	sex-specific storage-protein 2	Bombyx mori	30-33
27374983-3	2016	Further results confirmed that lysine acetylation could stabilize and up-regulate the protein level of anti-apoptosis protein SP2, thereby improving the survival of H2O2-treated BmN cells and suppressing the apoptosis induced by H2O2.	Lysine	31-37	sex-specific storage-protein 2	Bombyx mori	126-129
27374983-5	2016	Our results showed that the increase in the acetylation level by TSA could decrease the ubiquitination and improve the protein level of SP2, indicating that lysine acetylation could influence the SP2 protein level through competition between ubiquitination and the suppression of ubiquitin-mediated proteasomal degradation, thereby stabilizing the protein.	Lysine	157-163	sex-specific storage-protein 2	Bombyx mori	136-139
27374983-5	2016	Our results showed that the increase in the acetylation level by TSA could decrease the ubiquitination and improve the protein level of SP2, indicating that lysine acetylation could influence the SP2 protein level through competition between ubiquitination and the suppression of ubiquitin-mediated proteasomal degradation, thereby stabilizing the protein.	Lysine	157-163	sex-specific storage-protein 2	Bombyx mori	196-199
27374983-7	2016	The crosstalk between lysine acetylation and ubiquitination of SP2 might imply an important role of lysine acetylation for nutrient storage and utilization in silkworm.	Lysine	100-106	sex-specific storage-protein 2	Bombyx mori	63-66
27268279-5	2016	We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells.	Lysine	21-27	androgen receptor	Homo sapiens	228-230
27268279-6	2016	PKN1 or WDR5 knockdown severely inhibited KAT8 association with AR target genes and histone H4 lysine 16 acetylation upon androgen treatment.	Lysine	95-101	WD repeat domain 5	Homo sapiens	8-12
27143357-6	2016	Primary sequence alignment of different Cxs shows the presence of well conserved glutamate residues in the C terminus of TM-1; only Cx26 contains a lysine in that position (lysine 41).	Lysine	148-154	gap junction protein beta 2	Homo sapiens	132-136
27304234-0	2016	Correction to Protein Lysine Acetylation by p300/CBP.	Lysine	22-28	CREB binding protein	Homo sapiens	49-52
27460191-7	2016	Of note, we found that mimicking GRP78 acetylation by substituting the lysine at residue 633, one of the deacetylated sites of HDAC6, with a glutamine resulted in decreased GRP78 secretion and impaired tumour cell growth in vitro.	Lysine	71-77	heat shock protein family A (Hsp70) member 5	Homo sapiens	33-38
27460191-7	2016	Of note, we found that mimicking GRP78 acetylation by substituting the lysine at residue 633, one of the deacetylated sites of HDAC6, with a glutamine resulted in decreased GRP78 secretion and impaired tumour cell growth in vitro.	Lysine	71-77	histone deacetylase 6	Homo sapiens	127-132
27217333-4	2016	In the present study, we showed that histone methyltransferase G9a- and Suv39H-mediated histone H3 lysine 9 (H3K9) methylations contributed to PDK4 silencing in hepatic cells.	Lysine	99-105	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	143-147
27106782-2	2016	Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been demonstrated as a histone demethylase that specifically targets di-methyl groups and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3).	Lysine	187-193	lysine demethylase 6A	Homo sapiens	67-70
27348334-2	2016	Current bioluminescence (BL) methods are limited in detecting FAAH activity within 5 h. Herein, by rational design of a latent BL probe (d-Cys-Lys-CBT)2 (1), we developed a "smart" method of intracellular reduction-controlled self-assembly and FAAH-directed disassembly of its cyclic d-luciferin-based nanoparticles (i.e., 1-NPs) for persistent BL imaging of FAAH activity in vitro, in cells, and in vivo.	Lysine	143-146	fatty acid amide hydrolase	Homo sapiens	62-66
27348334-2	2016	Current bioluminescence (BL) methods are limited in detecting FAAH activity within 5 h. Herein, by rational design of a latent BL probe (d-Cys-Lys-CBT)2 (1), we developed a "smart" method of intracellular reduction-controlled self-assembly and FAAH-directed disassembly of its cyclic d-luciferin-based nanoparticles (i.e., 1-NPs) for persistent BL imaging of FAAH activity in vitro, in cells, and in vivo.	Lysine	143-146	fatty acid amide hydrolase	Homo sapiens	244-248
27348334-2	2016	Current bioluminescence (BL) methods are limited in detecting FAAH activity within 5 h. Herein, by rational design of a latent BL probe (d-Cys-Lys-CBT)2 (1), we developed a "smart" method of intracellular reduction-controlled self-assembly and FAAH-directed disassembly of its cyclic d-luciferin-based nanoparticles (i.e., 1-NPs) for persistent BL imaging of FAAH activity in vitro, in cells, and in vivo.	Lysine	143-146	fatty acid amide hydrolase	Homo sapiens	244-248
27302062-4	2016	Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.	Lysine	56-62	beta-secretase 1	Homo sapiens	30-35
27302062-4	2016	Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.	Lysine	102-108	beta-secretase 1	Homo sapiens	122-127
27302062-10	2016	Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.	Lysine	116-122	beta-secretase 1	Homo sapiens	90-95
27143357-7	2016	Neutralization of lysine 41 in Cx26 increases the voltage dependence of the slow gate.	Lysine	18-24	gap junction protein beta 2	Homo sapiens	31-35
26640146-5	2016	ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27.	Lysine	188-194	lysine demethylase 6A	Homo sapiens	73-76
27248781-6	2016	The PSMA-mediated internalization of (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu displayed a time-dependent manner, allowing the desired drug delivery and release within tumor cells.	Lysine	61-64	folate hydrolase 1	Homo sapiens	4-8
27248781-8	2016	Small animal PET imaging with (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu exhibited significantly higher uptake (p &lt; 0.01) in the PSMA positive PC3-PIP tumors (4.30 +- 0.20%ID/g) at 1 h postinjection than in the PSMA negative PC3-Flu tumors (1.12 +- 0.42%ID/g).	Lysine	54-57	folate hydrolase 1	Homo sapiens	126-130
27248781-8	2016	Small animal PET imaging with (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu exhibited significantly higher uptake (p &lt; 0.01) in the PSMA positive PC3-PIP tumors (4.30 +- 0.20%ID/g) at 1 h postinjection than in the PSMA negative PC3-Flu tumors (1.12 +- 0.42%ID/g).	Lysine	54-57	folate hydrolase 1	Homo sapiens	208-212
27131890-4	2016	Here we report the development of a novel kinetic method for measuring isopeptidase activity of human TG2 by monitoring decrease in the fluorescence polarization of a protein substrate previously formed by crosslinking fluorescently labeled glutamine donor FLpepT26 to S100A4 at a specific lysine residue.	Lysine	290-296	transglutaminase 2	Homo sapiens	102-105
27321670-5	2016	Ubiquitination of lysines in Hrd1"s RING-finger domain is required for substrate retrotranslocation in vitro and for ERAD in vivo.	Lysine	18-25	E3 ubiquitin-protein ligase HRD1	Saccharomyces cerevisiae S288C	29-33
26640146-6	2016	The preferential binding of the PHD finger of ASXL2 to the dimethylated H3 lysine 4 may account for its requirement for ERalpha activation.	Lysine	75-81	estrogen receptor 1	Homo sapiens	120-127
27264992-5	2016	Selective monoalkylation of a histone H4-mimicking peptide, containing a lysine to cysteine residue substitution (K12C), resulted in acetyl-lysine mimic incorporation, with high affinity for the BRD4 bromodomain.	Lysine	73-79	bromodomain containing 4	Homo sapiens	195-199
27332697-2	2016	p300/CBP is a multidomain protein and possesses a highly conserved bromodomain that has been shown to bind acetylated Lys residues in both proteins and various small molecules, including I-CBP112 and CBP30.	Lysine	118-121	CREB binding protein	Homo sapiens	5-8
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	94-98
27226597-4	2016	We used the genetic code expansion concept to produce natively folded, site-specific, and lysine-acetylated Sirt1-3 substrate proteins, namely Ras-related nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation reaction.	Lysine	90-96	tumor protein p53	Homo sapiens	164-167
27226597-4	2016	We used the genetic code expansion concept to produce natively folded, site-specific, and lysine-acetylated Sirt1-3 substrate proteins, namely Ras-related nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation reaction.	Lysine	90-96	peptidylprolyl isomerase F	Homo sapiens	199-212
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	114-121
27391784-7	2016	Treatment of mice bearing either a cell line or two patient-derived xenograft models of synovial sarcoma leads to dose-dependent tumor growth inhibition with correlative inhibition of trimethylation levels of the EZH2-specific substrate, lysine 27 on histone H3.	Lysine	238-244	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	213-217
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	173-177
27295432-8	2016	These studies reveal how the PTEN E3 ligases WWP2 and NEDD4-1 exhibit distinctive properties in Lys selectivity and sensitivity to PTEN phosphorylation.	Lysine	96-99	WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	45-49
27084712-4	2016	The adducts, aldoamine and N (epsilon)-carboxymethyl-lysine, attached preferably at lysine residues when the fibronectin peptide reacted with glycolaldehyde.	Lysine	53-59	fibronectin 1	Homo sapiens	109-120
27238211-9	2016	Analysis of the binding interactions revealed that compounds 1 and 2 shared a common quinazolin core structure and bound to BRD4(I) in a non-acetylated lysine mimetic mode.	Lysine	152-158	bromodomain containing 4	Homo sapiens	124-131
27238211-11	2016	Four potential hit-to-lead optimization candidates have been found, two of them bound to BRD4(I) in a non-acetylated lysine mimetic mode, being selective BRD4(I) inhibitors.	Lysine	117-123	bromodomain containing 4	Homo sapiens	89-96
27238211-11	2016	Four potential hit-to-lead optimization candidates have been found, two of them bound to BRD4(I) in a non-acetylated lysine mimetic mode, being selective BRD4(I) inhibitors.	Lysine	117-123	bromodomain containing 4	Homo sapiens	154-161
27084712-5	2016	When the fibronectin peptide reacted with methylglyoxal, modifications occurred at lysine and arginine residues.	Lysine	83-89	fibronectin 1	Homo sapiens	9-20
30155096-5	2016	The crystal structure of DERA before and after acetaldehyde incubation was determined at high resolution, revealing a covalently bound reaction product bridging the catalytically active lysine (K167) to a nearby cysteine (C47) in the deactivated enzyme.	Lysine	186-192	deoxyribose-phosphate aldolase	Homo sapiens	25-29
27261606-1	2016	EZH2 (Enhancer of zeste homolog 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is involved in repressing gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
27261606-1	2016	EZH2 (Enhancer of zeste homolog 2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is involved in repressing gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-33
27061807-3	2016	At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were modified.	Lysine	50-53	heat shock protein family B (small) member 6	Homo sapiens	12-17
27061807-3	2016	At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were modified.	Lysine	50-53	heat shock protein family B (small) member 6	Homo sapiens	66-71
27023356-0	2016	PEGylation of cytochrome c at the level of lysine residues mediated by a microbial transglutaminase.	Lysine	43-49	cytochrome c, somatic	Homo sapiens	14-26
26861461-6	2016	SIRT6 was recruited to the promoter of Bax, where it deacetylated histone 3 lysine 9 and suppressed its promoter activity.	Lysine	76-82	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
26534922-6	2016	In diabetic rats, depletion of EZH2 decreased histone 3 lysine 27 trimethylation (H3K27me3), increased glomerular TxnIP expression, induced podocyte injury, and augmented oxidative stress and proteinuria.	Lysine	56-62	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	31-35
27055146-6	2016	For example, EZH2 somatic mutations drive silencing of bivalent gene promoters through histone 3 lysine 27 trimethylation, whereas KMT2D (MLL2) mutations disrupt specific sets of enhancers through depletion of histone 3 lysine 4 mono and dimethylation (H3K4me1/me2).	Lysine	97-103	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
27055146-6	2016	For example, EZH2 somatic mutations drive silencing of bivalent gene promoters through histone 3 lysine 27 trimethylation, whereas KMT2D (MLL2) mutations disrupt specific sets of enhancers through depletion of histone 3 lysine 4 mono and dimethylation (H3K4me1/me2).	Lysine	220-226	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
26701983-1	2016	Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27166372-4	2016	Here, we combined chemical modification of lysines and multiple-reaction monitoring mass spectrometry to identify putative substrate-contacting residues in Arabidopsis thaliana PRORP1 (AtPRORP1), and subsequently validated these candidate sites by site-directed mutagenesis.	Lysine	43-50	proteinaceous RNase P 1	Arabidopsis thaliana	177-183
26701983-1	2016	Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27164166-6	2016	In contrast, 40% of the BSs of the pioneer factor forkhead box protein a (Foxa2) were dependent upon ER expression, and ER expression also affected the distribution of nucleosomes harboring dimethylated lysine 4 of Histone H3 around Foxa2 BSs.	Lysine	203-209	forkhead box A2	Mus musculus	74-79
27321414-0	2016	Correspondence: On the enzymology and significance of HSPA1 lysine methylation.	Lysine	60-66	heat shock protein family A (Hsp70) member 1A	Homo sapiens	54-59
27169594-3	2016	PRC2 acts as an epigenetic repressor through histone H3 lysine 27 trimethylation (H3K27me3), catalyzed by the histone methyltransferase enhancer of zeste homolog 2 protein (EZH2).	Lysine	56-62	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	173-177
27233966-3	2016	We report that cullin-5 (Cul-5), a cullin family scaffold protein, binds to TRAF6 and promotes TRAF6 polyubiquitination at Lys(63) in response to LPS stimulation.	Lysine	123-126	cullin 5	Mus musculus	15-23
27233966-3	2016	We report that cullin-5 (Cul-5), a cullin family scaffold protein, binds to TRAF6 and promotes TRAF6 polyubiquitination at Lys(63) in response to LPS stimulation.	Lysine	123-126	cullin 5	Mus musculus	25-30
27233966-3	2016	We report that cullin-5 (Cul-5), a cullin family scaffold protein, binds to TRAF6 and promotes TRAF6 polyubiquitination at Lys(63) in response to LPS stimulation.	Lysine	123-126	cullin 5	Mus musculus	15-21
27233966-3	2016	We report that cullin-5 (Cul-5), a cullin family scaffold protein, binds to TRAF6 and promotes TRAF6 polyubiquitination at Lys(63) in response to LPS stimulation.	Lysine	123-126	TNF receptor-associated factor 6	Mus musculus	95-100
27349785-3	2016	SET domain, bifurcated 1 (Setdb1, also known as Eset) is a histone 3 lysine 9 (H3K9)-specific methyltransferase and is essential for early development of embryos.	Lysine	69-75	SET domain, bifurcated 1	Mus musculus	26-32
27349785-3	2016	SET domain, bifurcated 1 (Setdb1, also known as Eset) is a histone 3 lysine 9 (H3K9)-specific methyltransferase and is essential for early development of embryos.	Lysine	69-75	SET domain, bifurcated 1	Mus musculus	48-52
27060134-3	2016	Mass spectrometry analysis of CSB identified lysine (K) 991 as a ubiquitylation site.	Lysine	45-51	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	30-33
27166372-4	2016	Here, we combined chemical modification of lysines and multiple-reaction monitoring mass spectrometry to identify putative substrate-contacting residues in Arabidopsis thaliana PRORP1 (AtPRORP1), and subsequently validated these candidate sites by site-directed mutagenesis.	Lysine	43-50	proteinaceous RNase P 1	Arabidopsis thaliana	185-193
27166372-5	2016	Using biochemical studies to characterize the wild-type (WT) and mutant derivatives, we found that AtPRORP1 exploits specific lysines strategically positioned at the tips of it"s V-shaped arms, in the first PPR motif and in the NYN domain proximal to the catalytic center, to bind and cleave pre-tRNA.	Lysine	126-133	proteinaceous RNase P 1	Arabidopsis thaliana	99-107
27315556-5	2016	Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impairs the interaction with the mRNA decay factors DCP2, EDC4, and XRN1, but not EDC3, thus remodeling P-body architecture.	Lysine	27-34	decapping mRNA 1A	Homo sapiens	38-43
27237050-3	2016	Here we demonstrate that SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain.	Lysine	125-131	SET domain, bifurcated 1	Mus musculus	25-31
27237050-5	2016	The resulting constitutive lysine-867 monoubiquitination is essential for SETDB1"s enzymatic activity and endogenous retrovirus silencing in murine embryonic stem cells.	Lysine	27-33	SET domain, bifurcated 1	Mus musculus	74-80
27191993-1	2016	The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
27076393-3	2016	The PSMA-targeting scaffold for all three agents utilized a similar Glu-urea-Lys-linker construct.	Lysine	77-80	folate hydrolase 1	Homo sapiens	4-8
27168161-1	2016	Histone three lysine 27 (H3K27) methyltransferase enhancer of zeste homolog 2 (EZH2) is a critical epigenetic modifier, which regulates gene transcription through the trimethylation of the H3K27 residue leading to chromatin compaction and gene repression.	Lysine	14-20	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	79-83
27092879-1	2016	Enhancer of zeste homolog 2 (EZH2), a catalytic core component of the Polycomb repressive complex 2 (PRC2), stimulates the silencing of target genes through histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27092879-1	2016	Enhancer of zeste homolog 2 (EZH2), a catalytic core component of the Polycomb repressive complex 2 (PRC2), stimulates the silencing of target genes through histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27226296-8	2016	Chromatin immunoprecipitation analysis revealed that Bhlhe40 accumulates in the T-box region of the Ifng locus and contributes to histone H3-lysine 9 acetylation of the Ifng locus, which is impaired without T-bet conditions.	Lysine	141-147	basic helix-loop-helix family, member e40	Mus musculus	53-60
27226296-8	2016	Chromatin immunoprecipitation analysis revealed that Bhlhe40 accumulates in the T-box region of the Ifng locus and contributes to histone H3-lysine 9 acetylation of the Ifng locus, which is impaired without T-bet conditions.	Lysine	141-147	interferon gamma	Mus musculus	169-173
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	RUNX family transcription factor 2	Homo sapiens	239-244
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	peroxisome proliferator activated receptor gamma	Homo sapiens	271-281
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	adiponectin, C1Q and collagen domain containing	Homo sapiens	288-299
27210019-0	2016	Lysines in the tetramerization domain of p53 selectively modulate G1 arrest.	Lysine	0-7	tumor protein p53	Homo sapiens	41-44
27129219-7	2016	HBP1-mediated repression of EZH2 through Wnt/beta-catenin signaling decreased the level of trimethylation of histone H3 at lysine 27 of overall and specific histone on the p21 promoter, resulting in p21 transactivation.	Lysine	123-129	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
27129283-7	2016	On the molecular level, IkappaBzeta directly activated the Il10 promoter at a proximal kappaB site and was required for the transcription-enhancing trimethylation of histone 3 at lysine 4.	Lysine	179-185	interleukin 10	Mus musculus	59-63
27210019-4	2016	By changing lysines 351 and 357 to arginine, thereby blocking all post-translational modifications of these residues, DNA binding and transcriptional regulation by p53 remain virtually unchanged.	Lysine	12-19	tumor protein p53	Homo sapiens	164-167
27210019-5	2016	On the other hand, by changing these lysines to glutamine (2KQ-p53), thereby neutralizing their positive charge and potentially mimicking acetylation, p53 is impaired in the induction of cell cycle arrest and yet can still effectively induce cell death.	Lysine	37-44	tumor protein p53	Homo sapiens	63-66
27210019-5	2016	On the other hand, by changing these lysines to glutamine (2KQ-p53), thereby neutralizing their positive charge and potentially mimicking acetylation, p53 is impaired in the induction of cell cycle arrest and yet can still effectively induce cell death.	Lysine	37-44	tumor protein p53	Homo sapiens	151-154
27210019-7	2016	Our findings show that strong induction of p21 is not sufficient to block H1299 cells in G1, and imply that modification of one or both of the lysines within the tetramerization domain may serve as a mechanism to shunt p53 from inducing cell cycle arrest.	Lysine	143-150	tumor protein p53	Homo sapiens	219-222
27115831-1	2016	DOT1L is the sole protein methyltransferase that methylates histone H3 on lysine 79 (H3K79), and is a promising drug target against cancers.	Lysine	74-80	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
27253878-2	2016	In Arabidopsis thaliana, mutation of the ATXR5 and ATXR6 histone methyltransferases causes reduction in histone H3 lysine 27 monomethylation, transcriptional upregulation of transposons, and a genome instability defect in which there is an accumulation of excess DNA corresponding to pericentromeric heterochromatin.	Lysine	115-121	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	41-46
27207647-1	2016	Trimethylation of lysine 27 on histone H3 (H3K27ME3) is a transcription-suppressive histone mark mediated by enhancer of zeste homolog 2 (EZH2).	Lysine	18-24	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	109-136
27207647-1	2016	Trimethylation of lysine 27 on histone H3 (H3K27ME3) is a transcription-suppressive histone mark mediated by enhancer of zeste homolog 2 (EZH2).	Lysine	18-24	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	138-142
27253695-2	2016	We investigated the effects of siRNA-mediated depletion of histone demethylase Jarid1A (KDM5A, RBP2), which demethylates transcription activating tri- and dimethylated lysine 4 at histone H3 (H3K4me3/me2), on growth characteristics and cellular response to radiation in several cancer cell lines.	Lysine	168-174	retinol binding protein 2	Homo sapiens	95-99
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Lysine	60-66	Avt1p	Saccharomyces cerevisiae S288C	9-13
27183271-1	2016	Nuclear receptor-binding SET domain protein 2 (NSD2) is a histone H3 lysine 36 (H3K36)-specific methyltransferase enzyme that is overexpressed in a number of cancers, including multiple myeloma.	Lysine	69-75	nuclear receptor binding SET domain protein 2	Homo sapiens	0-45
27183271-1	2016	Nuclear receptor-binding SET domain protein 2 (NSD2) is a histone H3 lysine 36 (H3K36)-specific methyltransferase enzyme that is overexpressed in a number of cancers, including multiple myeloma.	Lysine	69-75	nuclear receptor binding SET domain protein 2	Homo sapiens	47-51
27171135-6	2016	Our results indicate that the DI domain has a more negative impact than the DII domain does on binding to IR, and that the DI domain Pro-Leu-Lys residues are important factors for a different IR-A versus IR-B binding affinity of IGF-1.	Lysine	141-144	insulin like growth factor 1	Homo sapiens	229-234
27109047-4	2016	In the present study, we showed that ERG can directly bind to KDM4A (also known as JMJD2A), a histone demethylase that particularly demethylates lysine 9 on histone H3.	Lysine	145-151	ETS transcription factor ERG	Homo sapiens	37-40
27109047-7	2016	Furthermore, we found that ERG expression reduced histone H3 lysine 9 trimethylation at the YAP1 gene promoter, consistent with its epigenetic regulation through the ERG interaction partner, KDM4A.	Lysine	61-67	ETS transcription factor ERG	Homo sapiens	27-30
27109360-9	2016	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, enhances STAT3 activity by mediating its lysine methylation.	Lysine	137-143	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
27109360-9	2016	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, enhances STAT3 activity by mediating its lysine methylation.	Lysine	137-143	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
27109360-9	2016	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, enhances STAT3 activity by mediating its lysine methylation.	Lysine	137-143	signal transducer and activator of transcription 3	Homo sapiens	105-110
27232889-7	2016	Ube3a was associated with and specifically ubiquitinated lysine 227 within the cytoplasmic tail of Tkv, and promoted its proteasomal degradation in Schneider 2 cells.	Lysine	57-63	Ubiquitin protein ligase E3A	Drosophila melanogaster	0-5
27139003-2	2016	Here we describe the use of a silaffin-derived lysine-rich 39-amino-acid targeting sequence (Sil3T8) that directs a single chain fragment variable (scFv) antibody or an enhanced green fluorescent protein (EGFP) to assemble within the biosilica frustule, resulting in abundance of &gt;200 000 proteins per frustule.	Lysine	47-53	immunglobulin heavy chain variable region	Homo sapiens	148-152
27462461-6	2016	Moreover, the acetylation of Cdc25A at lysine 150, which was acetylated by p300/CBP and deacetylated by HDAC3, prevented the ubiquitin-mediated degradation of Cdc25A by the proteasome.	Lysine	39-45	CREB binding protein	Homo sapiens	80-83
26994210-5	2016	A SPOT peptide array approach and NMR titration experiments confirmed binding of Abeta(1-40) to the catalytic site of CypD mainly via residues Lys(16)-Glu(22) The peptide Abeta(16-20) representing this section showed submicromolar IC50 values for the peptidyl prolyl cis-trans isomerase activity of CypD and CypA and low-micromolar KD values in ITC experiments.	Lysine	143-146	amyloid beta precursor protein	Homo sapiens	81-86
27196068-6	2016	The levels of secreted Abeta, however, decreased in the presence of ABCG1 and ABCG4, but not ABCG4-KM, a nonfunctional Walker-A lysine mutant.	Lysine	128-134	amyloid beta precursor protein	Homo sapiens	23-28
26965372-7	2016	Furthermore, Ssdp1/2 recruit histone-modifying enzymes to the motor neuron-specifying LIM complex and trigger acetylation and lysine 4 trimethylation of histone H3, which are well-established chromatin marks for active transcription.	Lysine	126-132	single-stranded DNA binding protein 2	Mus musculus	13-20
27028856-5	2016	Sumoylation of TCF21 occurred at lysine residue 24 (K24).	Lysine	33-39	transcription factor 21	Homo sapiens	15-20
26943047-4	2016	In this study, we report that the deletion of a lysine residue at the extracellular region of CLEC4C yields a C-terminal dilysine motif that results in endoplasmic reticulum (ER) retention of the protein in transfected HeLa and Jurkat T lymphoma cell models.	Lysine	48-54	C-type lectin domain family 4 member C	Homo sapiens	94-100
27199994-1	2016	The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the trimethylation of the histone H3 lysine 27 (H3K27me3) promoting epigenetic gene silencing.	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
27199994-1	2016	The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the trimethylation of the histone H3 lysine 27 (H3K27me3) promoting epigenetic gene silencing.	Lysine	190-196	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
26679521-5	2016	We find that the SUMO-E2 conjugating enzyme Ubc9 and the SUMO E3 ligase PIAS3 associate with Smurf2 and promote its sumoylation at the distinct sites of Lysines 26 and 369.	Lysine	153-160	protein inhibitor of activated STAT 3	Mus musculus	72-77
26951200-5	2016	The PIAS3 binding region in GFI1 contains a conserved type I SUMOylation consensus element, centered on lysine-239 (K239).	Lysine	104-110	protein inhibitor of activated STAT 3	Homo sapiens	4-9
26679521-5	2016	We find that the SUMO-E2 conjugating enzyme Ubc9 and the SUMO E3 ligase PIAS3 associate with Smurf2 and promote its sumoylation at the distinct sites of Lysines 26 and 369.	Lysine	153-160	SMAD specific E3 ubiquitin protein ligase 2	Mus musculus	93-99
26915459-5	2016	Upon viral infection, TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.	Lysine	39-42	tripartite motif containing 9	Homo sapiens	22-27
27039394-3	2016	Recently, ubiquitously transcribed tetratricopeptide repeat on the X chromosome (UTX), a histone H3 lysine 27 (H3K27) demethylase, has been identified as a downregulated gene in TS immune cells.	Lysine	100-106	lysine demethylase 6A	Homo sapiens	81-84
27032457-0	2016	Rumen-protected methionine and lysine: effects on milk production and plasma amino acids of dairy cows with reference to metabolisable protein status.	Lysine	31-37	Weaning weight-maternal milk	Bos taurus	50-54
26952455-1	2016	The aim of the present study was to evaluate a library of poly-L-lysine (PLL)-graft (g)-polyethylene glycol (PEG) copolymers for the ability to encapsulate effectively a model protein, bovine serum albumin (BSA), and to characterize the stability and protein function of the resulting nanoparticle.	Lysine	58-71	albumin	Homo sapiens	192-205
26896748-6	2016	The acetylation of histone 3 at lysine residues 56 (H3K56), H3K14, H3K9, and H3K27, putative substrates of SIRT2 and SIRT6, was increased by maternal diabetes in vivo or high glucose in vitro, and these increases were blocked by SOD1 over-expression or tempol treatment.	Lysine	32-38	sirtuin 6	Mus musculus	117-122
26896748-6	2016	The acetylation of histone 3 at lysine residues 56 (H3K56), H3K14, H3K9, and H3K27, putative substrates of SIRT2 and SIRT6, was increased by maternal diabetes in vivo or high glucose in vitro, and these increases were blocked by SOD1 over-expression or tempol treatment.	Lysine	32-38	superoxide dismutase 1, soluble	Mus musculus	229-233
26929412-6	2016	By contrast, SMYD3 displayed a weak activity toward a VEGFR1 peptide, and the location of the acceptor lysine in the folded kinase domain of VEGFR1 requires drastic conformational rearrangements for juxtaposition of the acceptor lysine with the enzymatic active site.	Lysine	103-109	fms related receptor tyrosine kinase 1	Homo sapiens	141-147
27035287-10	2016	In addition, enhanced acetylation of histone H3 [H3 lysine (K)9 and H3K14] was detected surrounding the LPL promoter.	Lysine	52-58	lipoprotein lipase	Rattus norvegicus	104-107
26812966-3	2016	METHODS: The objectives of this study were to develop and characterize in vitro a novel poly-L-lysine (PLL) and polyethylene glycol (PEG) copolymer-based NP containing fluorescent-tagged bovine serum albumin (BSA), and conjugated with ERY1, a 12 amino acid peptide with high affinity for the RBC membrane protein glycophorin A (ENP).	Lysine	88-101	albumin	Homo sapiens	194-207
26812966-3	2016	METHODS: The objectives of this study were to develop and characterize in vitro a novel poly-L-lysine (PLL) and polyethylene glycol (PEG) copolymer-based NP containing fluorescent-tagged bovine serum albumin (BSA), and conjugated with ERY1, a 12 amino acid peptide with high affinity for the RBC membrane protein glycophorin A (ENP).	Lysine	88-101	glycophorin A (MNS blood group)	Homo sapiens	313-326
26631032-2	2016	Enhancer of zeste homolog 2 (EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and catalyzes the repressive histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	139-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
26631032-2	2016	Enhancer of zeste homolog 2 (EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and catalyzes the repressive histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	139-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
26945070-9	2016	Importantly, MFSD2A transported structurally related acylcarnitines but not a lysolipid without a negative charge, demonstrating the necessity of a negatively charged headgroup interaction with Lys-436 for transport.	Lysine	194-197	major facilitator superfamily domain containing 2A	Homo sapiens	13-19
27119146-5	2016	Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and cross-linking leading to connective tissue defects that include low bone mass and skin fragility.	Lysine	83-89	prolyl 3-hydroxylase family member 4 (non-enzymatic)	Mus musculus	8-12
27032069-7	2016	Abrogation of Lys-217 ubiquitination results in increased kinase activation, enhanced activation of downstream signaling pathways, and elevated IL-2 production following TCR stimulation.	Lysine	14-17	interleukin 2	Homo sapiens	144-148
26364600-1	2016	Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27.	Lysine	126-132	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-29
26364600-1	2016	Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27.	Lysine	126-132	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
26596838-2	2016	We previously demonstrated that aspirin acetylated the tumor suppressor protein p53 at lysine 382 in MDA-MB-231 human breast cancer cells.	Lysine	87-93	tumor protein p53	Homo sapiens	80-83
26929412-6	2016	By contrast, SMYD3 displayed a weak activity toward a VEGFR1 peptide, and the location of the acceptor lysine in the folded kinase domain of VEGFR1 requires drastic conformational rearrangements for juxtaposition of the acceptor lysine with the enzymatic active site.	Lysine	229-235	fms related receptor tyrosine kinase 1	Homo sapiens	141-147
26802971-7	2016	Histone 3 lysine 9 dimethylation (H3K9me2) was involved in the let-7d induced DRD3 TGS, indicating the chromatin-level silencing.	Lysine	10-16	dopamine receptor D3	Rattus norvegicus	78-82
27079798-0	2016	Lysine fatty acylation promotes lysosomal targeting of TNF-alpha.	Lysine	0-6	tumor necrosis factor	Homo sapiens	55-64
26903513-4	2016	Interestingly, a lysine-less form of NY-ESO-1 was as efficient as its wild-type counterpart in supplying the HLA-A*0201-restricted NY-ESO-1157-165 antigenic peptide.	Lysine	17-23	major histocompatibility complex, class I, A	Homo sapiens	109-114
26912663-0	2016	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	Lysine	25-28	nuclear receptor binding SET domain protein 2	Homo sapiens	52-56
26912663-0	2016	A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.	Lysine	25-28	nuclear receptor binding SET domain protein 2	Homo sapiens	114-118
26929406-9	2016	Reduction in acetylation of histone H3 Lys-27 accompanies loss of FoxO1 and FoxA1/A2 binding.	Lysine	39-42	forkhead box O1	Homo sapiens	66-71
26930370-8	2016	There was a reduction in the level of lysine in serum of FSHD, LGMD-2B and DM-1 patients as compared to normal subjects.	Lysine	38-44	dysferlin	Homo sapiens	63-70
27079798-3	2016	TNF-alpha is one of the first proteins known be modified by lysine fatty acylation (e.g. myristoylation).	Lysine	60-66	tumor necrosis factor	Homo sapiens	0-9
27079798-5	2016	However, the mechanistic details about how lysine fatty acylation regulates TNF-alpha secretion have been unknown.	Lysine	43-49	tumor necrosis factor	Homo sapiens	76-85
27079798-6	2016	Here we present experimental data supporting that lysine fatty acylation promotes lysosomal targeting of TNF-alpha.	Lysine	50-56	tumor necrosis factor	Homo sapiens	105-114
27070556-8	2016	For the side chain of amino acids adjacent to Lys in dipeptides, residue volume, polarizability, molecular volume and localized electrical effect were positively related to the yield of peptide bound pyrraline, while hydrophobicity and pKb were negatively related to the yield of peptide bound pyrraline.	Lysine	46-49	AKT serine/threonine kinase 1	Homo sapiens	236-239
26966065-11	2016	These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys(3) and degraded through Ser(16)-phosphorylation-mediated poly-ubiquitination during heart failure.	Lysine	75-78	phospholamban	Mus musculus	24-27
27070551-3	2016	Here we show that Setdb1, a lysine methyltransferase, controls the global level of histone H3 lysine 9 di-methyl (H3K9me2) mark in growing oocytes.	Lysine	28-34	SET domain, bifurcated 1	Mus musculus	18-24
26879868-7	2016	Moreover, ghrelin-mediated Akt Ser473 phosphorylation was attenuated by a Ras DN and LY 294002.	Lysine	85-87	AKT serine/threonine kinase 1	Homo sapiens	27-30
27043660-5	2016	Chromatin immunoprecipitation (ChIP) analysis demonstrated that BRCA1, EZH2, DNMT1/3a/b and histone H3 lysine 27 trimethylation (H3K27me3) are recruited to the endogenous FOXO3 promoter, further advocating that these proteins interact to modulate FOXO3 methylation and expression.	Lysine	103-109	forkhead box O3	Homo sapiens	171-176
27043660-5	2016	Chromatin immunoprecipitation (ChIP) analysis demonstrated that BRCA1, EZH2, DNMT1/3a/b and histone H3 lysine 27 trimethylation (H3K27me3) are recruited to the endogenous FOXO3 promoter, further advocating that these proteins interact to modulate FOXO3 methylation and expression.	Lysine	103-109	forkhead box O3	Homo sapiens	247-252
26853880-2	2016	We recently identified NOS2 as a potential target of the histone methyltransferase enhancer of zeste homolog 2 which mediates trimethylation of histone 3 at lysine 27 (H3K27me3).	Lysine	157-163	nitric oxide synthase 2	Homo sapiens	23-27
26783998-1	2016	DOT1L is a histone H3 lysine 79 (H3K79) methyltransferase mainly implicated in leukemia.	Lysine	22-28	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	263-269	nuclear receptor binding SET domain protein 2	Homo sapiens	138-143
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	263-269	nuclear receptor binding SET domain protein 2	Homo sapiens	145-150
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	309-315	nuclear receptor binding SET domain protein 2	Homo sapiens	138-143
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	309-315	nuclear receptor binding SET domain protein 2	Homo sapiens	145-150
26878866-2	2016	Carbamylation at sites of inflammation is due to cyanate formation during the neutrophil oxidative burst and may target lysine residues within the antimicrobial peptide LL-37.	Lysine	120-126	cathelicidin antimicrobial peptide	Homo sapiens	169-174
26878866-3	2016	The bactericidal and immunomodulatory properties of LL-37 depend on its secondary structure and cationic nature, which are conferred by arginine and lysine residues.	Lysine	149-155	cathelicidin antimicrobial peptide	Homo sapiens	52-57
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	268-271	cathelicidin antimicrobial peptide	Homo sapiens	205-210
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	cathelicidin antimicrobial peptide	Homo sapiens	205-210
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	cathelicidin antimicrobial peptide	Homo sapiens	205-210
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	cathelicidin antimicrobial peptide	Homo sapiens	205-210
27135271-4	2016	Moreover, approximately 30% of pediatric high grade gliomas (pedHGG) including GBM and DIPG harbor a lysine 27 mutation (K27M) in histone 3.3 (H3.3) which is correlated with poor outcome and was shown to influence EZH2 function.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	214-218
26851285-0	2016	Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway.	Lysine	30-36	tumor protein p53	Homo sapiens	15-18
26851285-0	2016	Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway.	Lysine	30-36	apoptotic peptidase activating factor 1	Homo sapiens	54-60
26851285-3	2016	Here we demonstrate that acetylation of p53 at Lys-120 up-regulates its transcriptional activity toward Apaf-1, a core component in the mitochondrial apoptotic pathway, and thus sensitizes caspase activation and apoptosis.	Lysine	47-50	tumor protein p53	Homo sapiens	40-43
26851285-3	2016	Here we demonstrate that acetylation of p53 at Lys-120 up-regulates its transcriptional activity toward Apaf-1, a core component in the mitochondrial apoptotic pathway, and thus sensitizes caspase activation and apoptosis.	Lysine	47-50	apoptotic peptidase activating factor 1	Homo sapiens	104-110
26851285-4	2016	We found that histone deacetylase (HDAC) inhibitors, including butyrate, augment Lys-120 acetylation of p53 and thus Apaf-1 expression by inhibiting HDAC1.	Lysine	81-84	tumor protein p53	Homo sapiens	104-107
26773607-2	2016	Anti-HER2 antibody-conjugated poly-l-lysine functionalized reduced graphene oxide (anti-HER2-rGO-PLL) nanocarriers were prepared to efficiently deliver doxorubicin targeting at the nucleus of HER2 over-expressing cancer cells.	Lysine	30-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	5-9
26773607-2	2016	Anti-HER2 antibody-conjugated poly-l-lysine functionalized reduced graphene oxide (anti-HER2-rGO-PLL) nanocarriers were prepared to efficiently deliver doxorubicin targeting at the nucleus of HER2 over-expressing cancer cells.	Lysine	30-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-92
26773607-2	2016	Anti-HER2 antibody-conjugated poly-l-lysine functionalized reduced graphene oxide (anti-HER2-rGO-PLL) nanocarriers were prepared to efficiently deliver doxorubicin targeting at the nucleus of HER2 over-expressing cancer cells.	Lysine	30-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-92
26851285-7	2016	Therefore, HDAC inhibitors can induce p53 acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.	Lysine	57-63	tumor protein p53	Homo sapiens	38-41
26851285-7	2016	Therefore, HDAC inhibitors can induce p53 acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.	Lysine	57-63	apoptotic peptidase activating factor 1	Homo sapiens	166-172
26800240-1	2016	Enhancer of zeste homolog 2 (EZH2) catalyses histone H3 lysine 27 trimethylation (H3K27me3) to silence tumour-suppressor genes in hepatocellular carcinoma (HCC) but the process of locus-specific recruitment remains elusive.	Lysine	56-62	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
26800240-1	2016	Enhancer of zeste homolog 2 (EZH2) catalyses histone H3 lysine 27 trimethylation (H3K27me3) to silence tumour-suppressor genes in hepatocellular carcinoma (HCC) but the process of locus-specific recruitment remains elusive.	Lysine	56-62	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
26786060-5	2016	TAFI also plays a role in inflammatory processes via the removal of C-terminal arginine or lysine residues from bradykinin, thrombin-cleaved osteopontin, C3a, C5a and chemerin.	Lysine	91-97	kininogen 1	Homo sapiens	112-122
27067043-1	2016	INTRODUCTION: Tissue transglutaminase (TG2) is a ubiquitously expressed enzyme capable of forming metabolically and mechanically stable crosslinks between the gamma-carboxamide of a glutamine acyl-acceptor substrate and the epsilon-amino functionality of a lysine acyl-donor substrate resulting in protein oligomers.	Lysine	257-263	transglutaminase 2	Homo sapiens	14-37
27234562-1	2016	Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3.	Lysine	121-127	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
27234562-1	2016	Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3.	Lysine	121-127	DOT1 like histone lysine methyltransferase	Homo sapiens	5-10
27162551-5	2016	Since the proteolytic cleavage by CTSL is the rate-limiting step for the drug activation, we sought to improve the substrate structure for CTSL activity by modifying the alpha-amino protecting group of lysine.	Lysine	202-208	cathepsin L	Homo sapiens	34-38
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Lysine	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-31
27042204-1	2016	BACKGROUND: Heteroligand Co(II) complexes involving imidazole and selected bio-relevant L-alpha-amino acids of four different groups (aspartic acid, lysine, histidine and asparagine) were formed by using a polymeric, pseudo-tetrahedral, semi-conductive Co(II) complex with imidazole-[Co(imid)2]n as starting material.	Lysine	149-155	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	253-259
27462448-7	2016	USP9x acts to deubiquitylate Angiomotin at lysine 496, resulting in stabilization of Angiomotin and lower YAP/TAZ activity.	Lysine	43-49	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	110-113
27162551-5	2016	Since the proteolytic cleavage by CTSL is the rate-limiting step for the drug activation, we sought to improve the substrate structure for CTSL activity by modifying the alpha-amino protecting group of lysine.	Lysine	202-208	cathepsin L	Homo sapiens	139-143
26990986-3	2016	Upon exposing cells to high glutamine concentration, GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the proteasome.	Lysine	73-80	glutamate-ammonia ligase	Homo sapiens	53-55
27014370-3	2016	We have previously demonstrated that 5-aza-2-deoxycytidine (5-azadC) treatment of FXS lymphoblastoid cell lines reactivates the FMR1 gene, concomitant with CpG sites demethylation, increased acetylation of histones H3 and H4 and methylation of lysine 4 on histone 3.	Lysine	244-250	fragile X messenger ribonucleoprotein 1	Homo sapiens	128-132
26813693-2	2016	SETDB1 methylates lysine 9 of histone 3 (H3K9), utilizing S-adenosylmethionine (SAM) as the methyl donor and its catalytic activity, has been reported to be regulated by a partner protein ATF7IP.	Lysine	18-24	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
26836503-4	2016	EZH2 catalyzes the methylation of lysine 27 on histone H3, a covalent chromatin modification that is associated with repressed heterochromatin.	Lysine	34-40	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25946208-2	2016	By taking advantage of the specific binding of BRD4 to acetylated lysine residues, we developed a FRET-based probe for visualizing histone H3 acetylation in living cells.	Lysine	66-72	bromodomain containing 4	Homo sapiens	47-51
26317848-1	2016	L3MBTL3 recognizes mono- and dimethylated lysine residues on histone tails.	Lysine	42-48	L3MBTL histone methyl-lysine binding protein 3	Homo sapiens	0-7
26555343-5	2016	Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(epsilon)-methylated lysine residue in different conformations during catalysis.	Lysine	40-46	lysine demethylase 4B	Homo sapiens	129-134
26119938-2	2016	In this study, we identify that the specific lysine residue 447 (K447) of HSPA5 could be modified with polyubiquitin for subsequent degradation through the ubiquitin proteasomal system, leading to the suppression of cell migration and invasion of breast cancer.	Lysine	45-51	heat shock protein family A (Hsp70) member 5	Homo sapiens	74-79
26119938-5	2016	Knock down of histone deacetylase-6 (HDAC6) increased the acetylation of HSPA5 at lysine residues 353 (K353) and reduced GP78-mediated ubiquitination of HSPA5 at K447 and then increased cell migration/invasion.	Lysine	82-88	histone deacetylase 6	Homo sapiens	14-35
26119938-5	2016	Knock down of histone deacetylase-6 (HDAC6) increased the acetylation of HSPA5 at lysine residues 353 (K353) and reduced GP78-mediated ubiquitination of HSPA5 at K447 and then increased cell migration/invasion.	Lysine	82-88	histone deacetylase 6	Homo sapiens	37-42
26119938-5	2016	Knock down of histone deacetylase-6 (HDAC6) increased the acetylation of HSPA5 at lysine residues 353 (K353) and reduced GP78-mediated ubiquitination of HSPA5 at K447 and then increased cell migration/invasion.	Lysine	82-88	heat shock protein family A (Hsp70) member 5	Homo sapiens	73-78
27005833-2	2016	Here we demonstrate that acetylation of C/EBPalpha at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPalpha DNA-binding ability and modulates C/EBPalpha transcriptional activity.	Lysine	54-60	CCAAT enhancer binding protein alpha	Homo sapiens	40-50
27005833-2	2016	Here we demonstrate that acetylation of C/EBPalpha at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPalpha DNA-binding ability and modulates C/EBPalpha transcriptional activity.	Lysine	54-60	CCAAT enhancer binding protein alpha	Homo sapiens	166-176
27005833-2	2016	Here we demonstrate that acetylation of C/EBPalpha at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPalpha DNA-binding ability and modulates C/EBPalpha transcriptional activity.	Lysine	54-60	CCAAT enhancer binding protein alpha	Homo sapiens	166-176
26797118-7	2016	Mass spectrometric analyses revealed that Cav-1 undergoes Lys-63-linked polyubiquitination, which serves as a lysosomal trafficking signal, and that the UIMs of Ankrd13 proteins bind preferentially to this ubiquitin chain type.	Lysine	58-61	caveolin 1	Homo sapiens	42-47
26986569-13	2016	In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305).	Lysine	63-69	tumor protein p53	Homo sapiens	80-83
26990986-5	2016	These findings reveal a feedback loop involving CRL4(CRBN) that adjusts GS protein levels in response to glutamine and uncover a new function for lysine acetylation.	Lysine	146-152	cereblon	Homo sapiens	53-57
26970896-7	2016	Moreover, LSD1 inhibitors worked synergistically with inhibition of DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, against MLL-rearranged leukemia.	Lysine	88-94	DOT1 like histone lysine methyltransferase	Homo sapiens	68-73
26747610-4	2016	The Rpd3S histone deacetylase utilizes the chromodomain-containing Eaf3 subunit and the PHD domain-containing Rco1 subunit to recognize nucleosomes that are methylated at lysine 36 of histone H3 (H3K36me).	Lysine	171-177	histone deacetylase 1	Homo sapiens	4-8
26719334-6	2016	We discover that lysine acetylation impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide exchange on RhoA, these two functions being prerequisites to constitute a bona fide GDI displacement factor.	Lysine	17-23	ras homolog family member A	Homo sapiens	146-150
28955863-3	2016	RESULTS: In case of CuO np-HSA interaction, the distances from the centre of Subdomain IIIA to Arg-472 is 2.113 A and Lys 475, Glu 492, Ala 490, Cys 487, Ala 490 are the bound neighbouring residues with Lys 475, Glu 492 at aliphatic region.	Lysine	118-121	albumin	Homo sapiens	27-30
28955863-3	2016	RESULTS: In case of CuO np-HSA interaction, the distances from the centre of Subdomain IIIA to Arg-472 is 2.113 A and Lys 475, Glu 492, Ala 490, Cys 487, Ala 490 are the bound neighbouring residues with Lys 475, Glu 492 at aliphatic region.	Lysine	203-206	albumin	Homo sapiens	27-30
28955863-6	2016	Moreover, Glu 285, Lys 286 forms aliphatic grove for TiO2-HSA, Ser-287 at the centre region form hydrogen bond with nanoparticle and Leu 283, Leu 284 forming hydrophopobic grove for TiO2 nanoparticle-HSA interaction.	Lysine	19-22	albumin	Homo sapiens	58-61
28955863-6	2016	Moreover, Glu 285, Lys 286 forms aliphatic grove for TiO2-HSA, Ser-287 at the centre region form hydrogen bond with nanoparticle and Leu 283, Leu 284 forming hydrophopobic grove for TiO2 nanoparticle-HSA interaction.	Lysine	19-22	albumin	Homo sapiens	200-203
26825875-8	2016	These results suggest that one of the consequences of oxidative stress in mammalian spermatozoa is the inhibition of PON-1, which then enhances the availability of homocysteine thiolactone to interact with the epsilon-amino group of lysine residues on sperm proteins, triggering a raft of significant biological changes in these cells that ultimately compromise sperm function.	Lysine	233-239	paraoxonase 1	Homo sapiens	117-122
26934956-1	2016	The chromodomain of HP1alpha binds directly to lysine 9-methylated histone H3 (H3K9me).	Lysine	47-53	H3 clustered histone 14	Homo sapiens	75-77
26934956-1	2016	The chromodomain of HP1alpha binds directly to lysine 9-methylated histone H3 (H3K9me).	Lysine	47-53	H3 clustered histone 14	Homo sapiens	79-85
26888970-9	2016	Restoring the expression of RAD51 and BRCA1 by treatment with EZH2 inhibitor was dependent on reducing the enrichment of trimethylation of histone 3 lysine 27 epigenetic mark in their promoter regions.	Lysine	149-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	62-66
27281850-1	2016	In the Saccharomyces cerevisiae yeasts, the DOT1 gene product provides methylation of lysine 79 (K79) of hi- stone H3 and the SET2 gene product provides the methylation of lysine 36 (K36) of the same histone.	Lysine	86-92	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	44-48
26791102-8	2016	Second, miR-214 was able to prevent cell death by targeting EZH2, the catalytic core component of PRC2 complex that is responsible for tri-methylation reaction at lysine 27 (K27) of histone 3 (H3) (H3K27me3), by which As-induced miR-214 reduction resulted in an increased global H3K27me3 level and a compromised overexpression of a pro-apoptotic gene Bim.	Lysine	163-169	microRNA 214	Homo sapiens	8-15
26791102-8	2016	Second, miR-214 was able to prevent cell death by targeting EZH2, the catalytic core component of PRC2 complex that is responsible for tri-methylation reaction at lysine 27 (K27) of histone 3 (H3) (H3K27me3), by which As-induced miR-214 reduction resulted in an increased global H3K27me3 level and a compromised overexpression of a pro-apoptotic gene Bim.	Lysine	163-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	60-64
27281850-1	2016	In the Saccharomyces cerevisiae yeasts, the DOT1 gene product provides methylation of lysine 79 (K79) of hi- stone H3 and the SET2 gene product provides the methylation of lysine 36 (K36) of the same histone.	Lysine	172-178	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	44-48
26712829-8	2016	In silico dissection of the most significantly changed proteins revealed novel qualitative changes in lysine abundance contributing to the overall lysine increase and the nutritional rebalancing of the o2 and fl2 endosperm.	Lysine	102-108	prolamin 22 kDa alpha zein z1C2	Zea mays	209-212
26694085-3	2016	EZH2 is a histone methyltransferase that acts as the catalytic agent of the polycomb-repressive complex 2 (PRC2) to maintain gene repression via methylation of lysine 27 on histone H3 (H3K27).	Lysine	160-166	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
26850942-7	2016	Moreover, Ang II induced ATF3 SUMOylation at lysine 42, which is SUMO1 dependent.	Lysine	45-51	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	10-16
26856188-0	2016	Tc-99m Glu-Cys-Gly-His-Gly-Lys (ECG-HGK), a novel Tc-99m labeled hexapeptide for molecular tumor imaging.	Lysine	27-30	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	36-39
26850942-7	2016	Moreover, Ang II induced ATF3 SUMOylation at lysine 42, which is SUMO1 dependent.	Lysine	45-51	small ubiquitin-like modifier 1	Mus musculus	65-70
26807716-2	2016	Gene-poor regions are di- and trimethylated at lysine 9 of histone H3 (H3K9me2 and H3K9me3) by the histone methyltransferase Suv39h1.	Lysine	47-53	SUV39H1 histone lysine methyltransferase	Homo sapiens	125-132
26819089-3	2016	Here, we identified ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase involved in demethylating di- or tri-methylated histone 3 lysine 27 (H3K27me2/3), as a positive regulator for the expression of E-cadherin in the colon cancer cell line HCT-116.	Lysine	173-179	lysine demethylase 6A	Homo sapiens	87-90
26819089-3	2016	Here, we identified ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase involved in demethylating di- or tri-methylated histone 3 lysine 27 (H3K27me2/3), as a positive regulator for the expression of E-cadherin in the colon cancer cell line HCT-116.	Lysine	173-179	cadherin 1	Homo sapiens	243-253
26927806-8	2016	In addition, K91S mutation abrogated the interaction with Nef, indicating that Lys(91) plays a key role in the interaction.	Lysine	79-82	S100 calcium binding protein B	Homo sapiens	58-61
26915321-5	2016	Acetylation of NF-kappaB p65 at lysine 221 site was assessed by Western blot.	Lysine	32-38	nuclear factor kappa B subunit 1	Homo sapiens	15-24
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	cyclin dependent kinase inhibitor 2A	Homo sapiens	130-133
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	cyclin dependent kinase inhibitor 2A	Homo sapiens	135-140
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	cyclin dependent kinase inhibitor 2A	Homo sapiens	135-139
26653328-1	2016	Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins.	Lysine	76-82	histone deacetylase 6	Homo sapiens	0-21
26653328-1	2016	Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins.	Lysine	76-82	histone deacetylase 6	Homo sapiens	23-28
26769278-3	2016	Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-29
26769278-3	2016	Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	66-72	F-box and WD repeat domain containing 7	Homo sapiens	4-9
26901654-6	2016	A role for histone modifications in the tissue-specific pattern of Slc44a4 expression, however, was suggested by the findings that in mouse colon, histone H3 in the 5"-regulatory region of Slc44a4 is tri-methylated at lysine 4 and acetylated at lysine 9, whereas the tri-methylation at lysine 27 modification was negligible.	Lysine	218-224	solute carrier family 44, member 4	Mus musculus	67-74
26901654-6	2016	A role for histone modifications in the tissue-specific pattern of Slc44a4 expression, however, was suggested by the findings that in mouse colon, histone H3 in the 5"-regulatory region of Slc44a4 is tri-methylated at lysine 4 and acetylated at lysine 9, whereas the tri-methylation at lysine 27 modification was negligible.	Lysine	245-251	solute carrier family 44, member 4	Mus musculus	67-74
26901654-6	2016	A role for histone modifications in the tissue-specific pattern of Slc44a4 expression, however, was suggested by the findings that in mouse colon, histone H3 in the 5"-regulatory region of Slc44a4 is tri-methylated at lysine 4 and acetylated at lysine 9, whereas the tri-methylation at lysine 27 modification was negligible.	Lysine	245-251	solute carrier family 44, member 4	Mus musculus	189-196
26901654-6	2016	A role for histone modifications in the tissue-specific pattern of Slc44a4 expression, however, was suggested by the findings that in mouse colon, histone H3 in the 5"-regulatory region of Slc44a4 is tri-methylated at lysine 4 and acetylated at lysine 9, whereas the tri-methylation at lysine 27 modification was negligible.	Lysine	245-251	solute carrier family 44, member 4	Mus musculus	67-74
26901654-6	2016	A role for histone modifications in the tissue-specific pattern of Slc44a4 expression, however, was suggested by the findings that in mouse colon, histone H3 in the 5"-regulatory region of Slc44a4 is tri-methylated at lysine 4 and acetylated at lysine 9, whereas the tri-methylation at lysine 27 modification was negligible.	Lysine	245-251	solute carrier family 44, member 4	Mus musculus	189-196
26746851-4	2016	HDAC6 transiently bound to RIG-I and removed the lysine 909 acetylation in the presence of viral RNAs, promoting RIG-I sensing of viral RNAs.	Lysine	49-55	histone deacetylase 6	Mus musculus	0-5
26844555-5	2016	The design of the spacer-ligand joint peptide was validated by a competition assay for [3H]Lys-des-Arg9-BK binding to the human B1R applied to 4 synthetic peptides of 18 or 19 residues.	Lysine	91-94	bradykinin receptor B1	Homo sapiens	128-131
26844555-9	2016	EGFP-(Asn-Gly)15-Lys-des-Arg9-BK competed for the binding of [3H]Lys-des-Arg9-BK to human recombinant B1R, being only 10-fold less potent than the unlabeled form of Lys-des-Arg9-BK to do so.	Lysine	17-20	bradykinin receptor B1	Homo sapiens	102-105
26902152-0	2016	Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.	Lysine	65-71	YY1 transcription factor	Homo sapiens	35-45
26902152-3	2016	Here we reported the first methyltransferase, SET7/9 (KMT7), capable of methylating YY1 at two highly conserved lysine (K) residues, K173 and K411, located in two distinct domains, one in the central glycine-rich region and the other in the very carboxyl-terminus.	Lysine	112-118	YY1 transcription factor	Homo sapiens	84-87
26848759-1	2016	Protein arginine methyltransferase 6 (PRMT6) catalyses asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which has been shown to impede the deposition of histone H3 lysine 4 trimethylation (H3K4me3) by blocking the binding and activity of the MLL1 complex.	Lysine	180-186	protein arginine methyltransferase 6	Homo sapiens	0-36
26848759-1	2016	Protein arginine methyltransferase 6 (PRMT6) catalyses asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which has been shown to impede the deposition of histone H3 lysine 4 trimethylation (H3K4me3) by blocking the binding and activity of the MLL1 complex.	Lysine	180-186	protein arginine methyltransferase 6	Homo sapiens	38-43
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	81-87	F-box and WD repeat domain containing 7	Homo sapiens	4-9
26842955-3	2016	Here we find that MeCP2 could be SUMO-modified by the E3 ligase PIAS1 at Lys-412.	Lysine	73-76	protein inhibitor of activated STAT 1	Mus musculus	64-69
26843476-5	2016	In a systematic study of the ubiquitin-modified proteome, lysine 176 of CAV1 was identified as a potential post-translational modification site for ubiquitination.	Lysine	58-64	caveolin 1	Homo sapiens	72-76
26658161-5	2016	In the present study, we demonstrated that PRMT5 undergoes polyubiquitination, possibly through multiple lysine residues.	Lysine	105-111	protein arginine methyltransferase 5	Homo sapiens	43-48
26787900-3	2016	Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the lysine 433 residue.	Lysine	93-99	sirtuin 6	Mus musculus	20-25
26830124-2	2016	Herein, we use a suite of protein chemistry methods to explore how H2B-Ub stimulates hDot1L-mediated methylation of histone H3 on lysine 79 (H3K79me).	Lysine	130-136	DOT1 like histone lysine methyltransferase	Homo sapiens	85-91
26787850-0	2016	Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.	Lysine	66-72	nuclear receptor binding SET domain protein 2	Homo sapiens	25-29
26787850-1	2016	Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36).	Lysine	96-102	nuclear receptor binding SET domain protein 2	Homo sapiens	50-54
26761588-2	2016	To investigate the early events following acquisition of this mutation in mammalian cells we created a photoactivatable version of IDH2(R172K), in which K172 is replaced with a photocaged lysine (PCK), via genetic code expansion.	Lysine	188-194	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	131-135
26647312-5	2016	We found that ASXL3 interacts with BAP1, a hydrolase that removes mono-ubiquitin from histone H2A lysine 119 (H2AK119Ub1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.	Lysine	98-104	ASXL transcriptional regulator 3	Homo sapiens	14-19
26647312-5	2016	We found that ASXL3 interacts with BAP1, a hydrolase that removes mono-ubiquitin from histone H2A lysine 119 (H2AK119Ub1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.	Lysine	98-104	BRCA1 associated protein 1	Homo sapiens	35-39
26314334-4	2016	To determine the specific lysine residues in the N-terminal domain of phyA involved in light-induced ubiquitination and protein degradation, we aligned the amino acid sequence of the N-terminal domain of Arabidopsis phyA with those of phyA from other plant species.	Lysine	26-32	phytochrome A	Arabidopsis thaliana	70-74
26314334-4	2016	To determine the specific lysine residues in the N-terminal domain of phyA involved in light-induced ubiquitination and protein degradation, we aligned the amino acid sequence of the N-terminal domain of Arabidopsis phyA with those of phyA from other plant species.	Lysine	26-32	phytochrome A	Arabidopsis thaliana	216-220
26314334-4	2016	To determine the specific lysine residues in the N-terminal domain of phyA involved in light-induced ubiquitination and protein degradation, we aligned the amino acid sequence of the N-terminal domain of Arabidopsis phyA with those of phyA from other plant species.	Lysine	26-32	phytochrome A	Arabidopsis thaliana	216-220
26450989-6	2016	Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFbeta treatment.	Lysine	55-61	transforming growth factor beta 1	Homo sapiens	155-162
26581161-5	2016	On the other hand, the pRB1-SET1A complex may carry methyls(me) to occupy the position of H3K4, resulting in specific tri-methylation of forth lysine of histone H3 (H3K4me3).	Lysine	143-149	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	28-33
26731476-6	2016	ETV1 facilitated the recruitment of JMJD2A to the YAP1 promoter, leading to changes in histone lysine methylation in a human prostate cancer cell line.	Lysine	95-101	ETS variant transcription factor 1	Homo sapiens	0-4
26973856-2	2016	Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27)-specific methyltransferase, has been emerged as novel anticancer target.	Lysine	49-55	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
26973856-2	2016	Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27)-specific methyltransferase, has been emerged as novel anticancer target.	Lysine	49-55	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
26776511-5	2016	The nuclear ARID3B complex recruits histone demethylase 4C to reduce histone 3 lysine 9 trimethylation and promotes the transcription of stemness factors.	Lysine	79-85	AT-rich interaction domain 3B	Homo sapiens	12-18
26675548-6	2016	At the molecular level, we show that upon SSBs WWOX is modified at lysine 274 by ubiquitination mediated by the ubiquitin E3 ligase ITCH and interacts with ataxia telangiectasia-mutated (ATM).	Lysine	67-73	WW domain containing oxidoreductase	Homo sapiens	47-51
26787826-9	2016	The in silico and mutagenesis analyses further suggested that Nef-202 may interact with the C-terminal Cys-Lys-Val residues of HLA-A, which are absent in HLA-B.	Lysine	107-110	S100 calcium binding protein B	Homo sapiens	62-65
27303701-10	2016	Thus, the transcriptional rewiring of the lysine biosynthetic pathway in C. albicans involves not only neofunctionalization of the four LYS14-like genes but the attendant strengthening of control by Gcn4, indicating a coordinated response with a much broader scope for control of amino acid biosynthesis in this human pathogen.	Lysine	42-48	Lys14p	Saccharomyces cerevisiae S288C	136-141
27303701-15	2016	Our results therefore suggest that the regulation of the lysine biosynthetic pathway in Candida clade genomes involves gain of function by the master transcriptional regulator Gcn4, coincident with the neofunctionalization of the S. cerevisiae pathway-specific regulator Lys14.	Lysine	57-63	Lys14p	Saccharomyces cerevisiae S288C	271-276
26695096-10	2016	Here, we report that lysine acetylation at lysines K127 and K141 in the RhoGDIalpha immunoglobulin domain interferes with the interaction toward nonprenylated RhoA using a combined biochemical and biophysical approach.	Lysine	43-50	ras homolog family member A	Homo sapiens	159-163
26601948-9	2016	Finally, we generated a structural model of AMSH-STAM to show how the complex binds Lys(63)-linked ubiquitin chains and cleaves at the distal end.	Lysine	84-87	STAM binding protein	Homo sapiens	44-48
26644523-10	2016	Molecular studies showed a 42-base pair deletion in exon 11 of the KIT gene that would delete all or part of codons 558 to 572 (V559_D572del) and would change the 558-encoding amino acid from Lys to Asn (K558N).	Lysine	192-195	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	67-70
26695096-10	2016	Here, we report that lysine acetylation at lysines K127 and K141 in the RhoGDIalpha immunoglobulin domain interferes with the interaction toward nonprenylated RhoA using a combined biochemical and biophysical approach.	Lysine	21-27	ras homolog family member A	Homo sapiens	159-163
26787826-9	2016	The in silico and mutagenesis analyses further suggested that Nef-202 may interact with the C-terminal Cys-Lys-Val residues of HLA-A, which are absent in HLA-B.	Lysine	107-110	major histocompatibility complex, class I, A	Homo sapiens	127-132
26686419-5	2016	To clarify this question, we investigated the functional importance of ribosomal L1 domain and lysine (Lys) -rich region of CSIG.	Lysine	95-101	ribosomal L1 domain containing 1	Homo sapiens	124-128
26497210-1	2016	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3.	Lysine	144-150	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
26497210-1	2016	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3.	Lysine	144-150	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
26686419-0	2016	Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence.	Lysine	24-30	ribosomal L1 domain containing 1	Homo sapiens	61-65
26686419-5	2016	To clarify this question, we investigated the functional importance of ribosomal L1 domain and lysine (Lys) -rich region of CSIG.	Lysine	103-106	ribosomal L1 domain containing 1	Homo sapiens	124-128
26686419-0	2016	Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence.	Lysine	24-30	ribosomal L1 domain containing 1	Homo sapiens	67-73
26376067-6	2016	The involvement of the lysine methylation in cardiogenesis by attenuating the transcriptional activity of GATA4 in mice has been previously examined.	Lysine	23-29	GATA binding protein 4	Mus musculus	106-111
26549688-11	2016	Substitution of all its four putative lysine residues along with NDSM abolished the effect of SUMO-1-mediated transactivation function of PXR.	Lysine	38-44	nuclear receptor subfamily 1 group I member 2	Homo sapiens	138-141
26748706-1	2016	Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction.	Lysine	0-6	anti-Corynebacterium kutscheri	Mus musculus	20-23
26748706-1	2016	Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction.	Lysine	115-121	anti-Corynebacterium kutscheri	Mus musculus	20-23
26748827-5	2016	MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes.	Lysine	96-102	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
26748827-5	2016	MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes.	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
26586842-8	2016	The key targets of PRDM1 in migrating and/or gonadal PGCs, including genes for development, apoptosis, and prospermatogonial differentiation, showed only a modest overlap with those upon PGC specification, and were enriched with histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	240-246	progastricsin (pepsinogen C)	Mus musculus	53-56
26487698-6	2016	TG2 incorporates a glutamine donor peptide to Lys(100) in the C-terminal random coil region of S100A4.	Lysine	46-49	transglutaminase 2	Homo sapiens	0-3
26853287-0	2016	The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes.	Lysine	25-33	lysozyme	Homo sapiens	37-45
26853287-4	2016	In this study, the authors aimed to observe the effect of L-lysine as a chemical chaperone on structure and function of glycated lysozyme.	Lysine	58-66	lysozyme	Homo sapiens	129-137
26853287-5	2016	In this study, in vitro and in vivo effects of L-lysine on lysozyme glycation were investigated.	Lysine	47-55	lysozyme	Homo sapiens	59-67
26853287-6	2016	Lysozyme was incubated with glucose and/or L-lysine, followed by an investigation of its structure by electrophoresis, fluorescence spectroscopy, and circular dichroism spectroscopy and also assessment of its bactericidal activity against M. lysodeikticus.	Lysine	43-51	lysozyme	Homo sapiens	0-8
26853287-13	2016	Structure and function of glycated lysozyme are significantly improved by l-lysine; therefore it can be considered an effective therapeutic supplementation in T2DM, decreasing the risk of infection in these patients.	Lysine	74-82	lysozyme	Homo sapiens	35-43
27173965-5	2016	SAA2 specifically displayed binding to the N-terminal Thr1 residue in the S1 pocket of Mus musculus beta5 proteasome along with threonine, lysine and arginine; conventionally involved major amino acid residues in ligand binding.	Lysine	139-145	serum amyloid A 2	Mus musculus	0-4
27090907-9	2016	Furthermore, decreases in histone H3 acetylation, H3 monomethylation at lysine 4, and H3 trimethylation at lysine 27 after the Sr2+ activation step were observed in the PPN of Parp1-/- donor embryos.	Lysine	72-78	poly(ADP-ribose) polymerase 1	Homo sapiens	176-181
27247942-0	2016	Histone Lysine Methylation in TGF-beta1 Mediated p21 Gene Expression in Rat Mesangial Cells.	Lysine	8-14	transforming growth factor, beta 1	Rattus norvegicus	30-39
26631178-1	2016	It has been reported that the trimethylation of histone 3 on lysine 27 (H3K27me3) is required for enhancer of zeste homology 2 (EZH2)-mediated repression of various genes essential for tumorigenesis and tumor development.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	98-126
26631178-1	2016	It has been reported that the trimethylation of histone 3 on lysine 27 (H3K27me3) is required for enhancer of zeste homology 2 (EZH2)-mediated repression of various genes essential for tumorigenesis and tumor development.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	128-132
25986621-6	2016	To illustrate this, the canonical Wnt/beta-catenin pathway represses expression of PPARgamma mRNA, whereas the noncanonical Wnt pathway activates histone methyltransferases that inhibit PPARgamma transactivation via histone H3 lysine 9 (H3K9) methylation of its target genes.	Lysine	227-233	peroxisome proliferator activated receptor gamma	Homo sapiens	186-195
27090907-9	2016	Furthermore, decreases in histone H3 acetylation, H3 monomethylation at lysine 4, and H3 trimethylation at lysine 27 after the Sr2+ activation step were observed in the PPN of Parp1-/- donor embryos.	Lysine	107-113	poly(ADP-ribose) polymerase 1	Homo sapiens	176-181
27553735-7	2016	NEP was covalently adducted at Lys 93, Lys 472 by HNE via Michael addition.	Lysine	31-34	membrane metalloendopeptidase	Homo sapiens	0-3
26404016-3	2016	This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning.	Lysine	55-58	folate hydrolase 1	Homo sapiens	80-84
26404016-3	2016	This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning.	Lysine	55-58	folate hydrolase 1	Homo sapiens	148-182
26404016-3	2016	This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning.	Lysine	55-58	folate hydrolase 1	Homo sapiens	184-188
27553735-7	2016	NEP was covalently adducted at Lys 93, Lys 472 by HNE via Michael addition.	Lysine	39-42	membrane metalloendopeptidase	Homo sapiens	0-3
26823167-0	2016	Ordered self-assembly of the collagenous domain of adiponectin with noncovalent interactions via glycosylated lysine residues.	Lysine	110-116	adiponectin, C1Q and collagen domain containing	Homo sapiens	51-62
26519876-0	2016	Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA2 homologue from Bothrops pauloensis venom.	Lysine	52-55	phospholipase A2 group IB	Homo sapiens	59-63
27251074-1	2016	Precise regulation of chromatin structure is essential for proper development of higher eukaryotes, and methylation of histone H3 at lysine-27 (H3K27) by the Polycomb Repressive Complex 2 (PRC2) component EZH2 has emerged as an important and conserved mechanism to ensure silencing of developmentally regulated genes.	Lysine	133-139	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	205-209
26605782-0	2016	Inhibition of Pathogenic Mutant SOD1 Aggregation in Cultured Motor Neuronal Cells by Prevention of Its SUMOylation on Lysine 75.	Lysine	118-124	superoxide dismutase 1, soluble	Mus musculus	32-36
26045091-1	2016	TGF-beta1 activity results in methylation of lysine 4 of histone H3 (H3K4) through SET domain-containing lysine methyltransferase 7/9 (SET7/9) induction, which is important for the transcriptional activation of fibrotic genes in vitro.	Lysine	45-51	transforming growth factor beta 1	Homo sapiens	0-9
27246205-3	2016	HDAC2 has been shown to be modified by SUMO1 at lysine 462.	Lysine	48-54	histone deacetylase 2	Homo sapiens	0-5
27246218-3	2016	SIRT4, one of the least characterized mitochondrial sirtuins, was shown to be the first known cellular lipoamidase, removing lipoyl modifications from lysine residues of substrates.	Lysine	151-157	sirtuin 4	Homo sapiens	0-5
27121714-1	2016	Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., alpha-tubulin, Hsp90 and cortactin.	Lysine	78-84	histone deacetylase 6	Homo sapiens	0-21
27121714-1	2016	Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., alpha-tubulin, Hsp90 and cortactin.	Lysine	78-84	histone deacetylase 6	Homo sapiens	23-28
27290915-1	2016	BRD4, an epigenetic regulator that recognizes and binds the acetylated lysine residues in histone, has been reported as a potential therapeutic target for cancers.	Lysine	71-77	bromodomain containing 4	Homo sapiens	0-4
26548512-4	2016	The results demonstrated that the transcriptional activities of Wnt2b and Wnt7b were abnormally upregulated in mouse fetuses with NTDs and, in the GC-rich promoters of these genes, histone 3 lysine 4 (H3K4) acetylation was enriched, whereas H3K27 trimethylation was reduced.	Lysine	191-197	wingless-type MMTV integration site family, member 7B	Mus musculus	74-79
25730443-0	2016	Interaction of arginine, lysine, and guanidine with surface residues of lysozyme: implication to protein stability.	Lysine	25-31	lysozyme	Homo sapiens	72-80
25730443-3	2016	To understand this, we herein perform molecular dynamics simulations of lysozyme in the presence of three commonly used additives: arginine, lysine, and guanidine.	Lysine	141-147	lysozyme	Homo sapiens	72-80
26605782-7	2016	We next show that preventing the SUMOylation of mutant SOD1 by the substitution of lysine 75, the SUMOylation site of SOD1, significantly reduces the number of motor neuronal cells with aggregates.	Lysine	83-89	superoxide dismutase 1, soluble	Mus musculus	55-59
26605782-7	2016	We next show that preventing the SUMOylation of mutant SOD1 by the substitution of lysine 75, the SUMOylation site of SOD1, significantly reduces the number of motor neuronal cells with aggregates.	Lysine	83-89	superoxide dismutase 1, soluble	Mus musculus	118-122
27610140-6	2016	The application of mechanical strain increased vascular endothelial growth factor A secretion 2-4-fold for CPCs cultured on poly-L-lysine, laminin, or a naturally derived cardiac extracellular matrix.	Lysine	124-137	vascular endothelial growth factor A	Homo sapiens	47-83
26385168-2	2015	Pinometostat (EPZ-5676) is a small molecule inhibitor of the DOT1L enzyme, a histone methyltransferase that methylates lysine 79 of histone H3.	Lysine	119-125	DOT1 like histone lysine methyltransferase	Homo sapiens	61-66
26556865-4	2015	In this process, PPARalpha/C102 was critical for PPARalpha binding to BH3 domain of Bcl2, subsequently, PPARalpha transferred K48-linked polyubiquitin to lysine-22 site of Bcl2 resulting in its ubiquitination and proteasome-dependent degradation.	Lysine	154-160	BCL2 apoptosis regulator	Homo sapiens	84-88
26556865-4	2015	In this process, PPARalpha/C102 was critical for PPARalpha binding to BH3 domain of Bcl2, subsequently, PPARalpha transferred K48-linked polyubiquitin to lysine-22 site of Bcl2 resulting in its ubiquitination and proteasome-dependent degradation.	Lysine	154-160	BCL2 apoptosis regulator	Homo sapiens	172-176
26544624-6	2015	MSC-induced SIRT1 activity was correlated with decreased acetylation of BMAL1 and increased acetylation of histone 3 lysine 9 at the Per2 promoter E-Box in mammary tissue.	Lysine	117-123	sirtuin 1	Rattus norvegicus	12-17
26606380-4	2015	Increasing cationicity by the substitution Glu(17)   l-Lys in Ps-1Pb and Glu(27)   l-Lys in Ps-2Pa generates analogues with increased cytotoxicity and reduced insulin-releasing potency.	Lysine	83-88	insulin	Homo sapiens	159-166
26689258-7	2015	However, when the peptides were mutated on two lysine residues (K15 and K20), the inhibition effects were greatly reduced indicating these two amino acids are key residues for the initial binding of CXCL8 to CXCR1.	Lysine	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	199-204
26586479-4	2015	Here, we demonstrated that the protein lysine methyltransferase SUV420H1 tri-methylated ERK1 at lysines 302 and 361, and that substitution of methylation sites diminished phosphorylation levels of ERK1.	Lysine	96-103	mitogen-activated protein kinase 3	Homo sapiens	88-92
26586479-4	2015	Here, we demonstrated that the protein lysine methyltransferase SUV420H1 tri-methylated ERK1 at lysines 302 and 361, and that substitution of methylation sites diminished phosphorylation levels of ERK1.	Lysine	96-103	mitogen-activated protein kinase 3	Homo sapiens	197-201
26515065-3	2015	Following food deprivation, the expression and acetylation of the p65 of NF-kappaB on lysine 310 increase markedly in muscles.	Lysine	86-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
26515065-4	2015	NF-kappaB inhibition in mouse muscles by overexpression of the IkappaBalpha superrepressor (IkappaBalpha-SR) or of p65 mutated at Lys-310 prevented atrophy.	Lysine	130-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
26588227-0	2015	Anti-inflammatory Effects of Poly-L-lysine in Intestinal Mucosal System Mediated by Calcium-Sensing Receptor Activation.	Lysine	29-42	calcium sensing receptor	Homo sapiens	84-108
26651941-5	2015	Surprisingly, JNK-mediated viral gene induction occurs independently of histone demethylases that remove repressive lysine modifications.	Lysine	116-122	mitogen-activated protein kinase 8	Homo sapiens	14-17
26588227-2	2015	Poly-L-lysine (PL) is a basic polypeptide identified for its role in the activation of CaSR through allosteric binding.	Lysine	0-13	calcium sensing receptor	Homo sapiens	87-91
26651941-6	2015	Rather, JNK signaling results in a histone methyl/phospho switch on HSV lytic promoters, a mechanism permitting gene expression in the presence of repressive lysine methylation.	Lysine	158-164	mitogen-activated protein kinase 8	Homo sapiens	8-11
26656916-7	2015	In addition, we observed small but significant activity against organophosphorothiotes pesticides, m-parathion, coumaphos and malathion.The availability of fair amount of active protein allowed to pinpoint, by mass-spectrometry, ubiquitination of Lys 168 induced in rPON2 by HeLa extract and to correlate such post-translational modification to the modulation of catalytic activity.	Lysine	247-250	paraoxonase 2	Rattus norvegicus	266-271
26631469-4	2015	We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1.	Lysine	146-149	oligodendrocyte transcription factor 1	Homo sapiens	161-166
26620909-5	2015	Experimental and mathematical analyses revealed that the K63-linked ubiquitination of NLRC5 at lysine 1,178 generates a coherent feedforward loop to further sensitize NF-kappaB activation.	Lysine	95-101	NLR family CARD domain containing 5	Homo sapiens	86-91
26511091-1	2015	Lysine (K)-specific demethylase 4B (KDM4B) is a histone H3K9 demethylase and is reported to activate gene transcription through regulation of chromatin structures.	Lysine	0-6	lysine demethylase 4B	Homo sapiens	36-41
26399751-5	2015	Positively charged residues with different side chain lengths were incorporated at each Arg and Lys position in the Tat-derived peptide to enhance TAR RNA binding.	Lysine	96-99	RNA binding motif protein 8A	Homo sapiens	147-150
26526725-3	2015	We previously showed in mice that reduction of histone H3 lysine 9 trimethylation (H3K9me3) through ectopic expression of the H3K9me3 demethylase Kdm4d greatly improves SCNT embryo development.	Lysine	58-64	lysine (K)-specific demethylase 4D	Mus musculus	146-151
26330467-3	2015	Here, we analyze differential histone modifications between WT and MED23(-/-) (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone modification.	Lysine	129-135	mediator complex subunit 23	Homo sapiens	153-158
26626423-4	2015	Here we show that LSD1, a lysine demethylase, regulates histone H3 lysine 4 di-methylation (H3K4me2) in mouse oocytes and is essential for meiotic progression.	Lysine	26-32	lysine (K)-specific demethylase 1A	Mus musculus	18-22
26614667-6	2015	Finally, Unr is post-translationally modified by phosphorylation and lysine acetylation, although it is not yet known how these modifications affect Unr activity.	Lysine	69-75	cold shock domain containing E1	Homo sapiens	9-12
26350773-3	2015	When Vero cells and DF1 cells were transfected with mutant p17 in which lysine (K) at position 122 and arginine (R) at position 123 were mutated to alanine (A), the expression level of LC3 II decreased dramatically after transfection.	Lysine	72-78	family with sequence similarity 72 member B	Homo sapiens	59-62
26189760-4	2015	Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters.	Lysine	204-210	sirtuin 6	Mus musculus	17-22
26633535-5	2015	Through mono-ubiquitination of histone H2A at lysine 119 (H2A-K119Ub), BMI1 represses multiple gene loci; among these, the INK4A/ARF locus has been most thoroughly investigated.	Lysine	46-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	123-132
26324181-5	2015	Crucially, diabetes represses transcription of the key myeloid transcription factor CEBPA via diminished H3 Lys 27 promoter acetylation, leading to a failure in monocyte and granulocyte maturation.	Lysine	108-111	CCAAT enhancer binding protein alpha	Homo sapiens	84-89
26628361-3	2015	Ectopically expressed Prm1 forms scattered foci in the nuclei of fibroblasts, which coalescence into spermatid-like structures, concomitant with a loss of histones and a reprogramming barrier, H3 lysine 9 methylation.	Lysine	196-202	protamine 1	Homo sapiens	22-26
25941038-6	2015	These data suggest that mechanisms involving CBP HAT-mediated lysine acetylation of nuclear proteins support selectively long-term encoding in the mPFC circuits.	Lysine	62-68	CREB binding protein	Homo sapiens	45-48
26341139-0	2015	Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis.	Lysine	51-57	cyclin dependent kinase inhibitor 2A	Homo sapiens	94-97
26362868-0	2015	The regulation of ER export and Golgi retention of ST3Gal5 (GM3/GM4 synthase) and B4GalNAcT1 (GM2/GD2/GA2 synthase) by arginine/lysine-based motif adjacent to the transmembrane domain.	Lysine	128-134	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	51-58
26248577-1	2015	Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1.4K26) and plays a crucial role in the regulation of gene expression as well as in heterochromatin formation.	Lysine	148-154	protein tyrosine phosphatase, receptor type, J	Mus musculus	27-49
26307368-2	2015	We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway.	Lysine	32-38	thymoma viral proto-oncogene 1	Mus musculus	91-94
26307368-2	2015	We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway.	Lysine	40-43	thymoma viral proto-oncogene 1	Mus musculus	91-94
26416882-0	2015	BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation.	Lysine	110-116	Nanog homeobox	Mus musculus	13-18
26376801-8	2015	Collectively, these results indicate that FOXO3a is essential for dexamethasone response in B-ALL cells, and its nuclear translocation and activation is associated with its phosphorylation on Ser-7 and acetylation on Lys-242/245.	Lysine	217-220	forkhead box O3	Homo sapiens	42-48
26416882-6	2015	Analysis of histone H3 within the Nanog proximal enhancer revealed that H3 lysine 9/14 (H3K9/14) acetylation increased in BRG1-depleted embryos and ESCs.	Lysine	75-81	Nanog homeobox	Mus musculus	34-39
26370511-5	2015	EZH2 mediates the trimethylation of histone H3 at lysine 27 (H3K27me3), a modification associated with chromatin compaction and gene silencing.	Lysine	50-56	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
26564862-4	2015	This reprogramming process enriched trimethylated histone H3 lysine 4, monoacetylated histone H3 lysine 9, and Baf60c at the Nkx2.5 cardiac enhancer region by the chromatin immunoprecipitation quantitative polymerase chain reaction assay.	Lysine	61-67	NK2 homeobox 5	Homo sapiens	125-131
26376801-6	2015	Furthermore, two posttranslational modifications were uncovered, phosphorylation on Ser-7 and acetylation on Lys-242/5, that associated with FOXO3a activation by dexamethasone.	Lysine	109-112	forkhead box O3	Homo sapiens	141-147
26519772-8	2015	GPa to GPb interconversion is dependent on the conformational state of phosphorylase which can be relaxed (R) or tense (T) depending on the concentrations of allosteric effectors such as glucose, glucose 6-phosphate and adenine nucleotides and on the acetylation state of lysine residues.	Lysine	272-278	glycophorin B (MNS blood group)	Homo sapiens	7-10
26438600-7	2015	Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor alpha (PPARalpha) in activating their target genes upon fasting or glucagon stimulation.	Lysine	34-40	peroxisome proliferator activated receptor alpha	Mus musculus	108-156
26438600-7	2015	Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor alpha (PPARalpha) in activating their target genes upon fasting or glucagon stimulation.	Lysine	34-40	peroxisome proliferator activated receptor alpha	Mus musculus	158-167
26437570-6	2015	Occupancy of the +1 nucleosome in FLC chromatin increased in a time-dependent manner over a 4-week low temperature treatment concomitant with decreased histone acetylation and increased trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	215-221	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	34-37
26564862-4	2015	This reprogramming process enriched trimethylated histone H3 lysine 4, monoacetylated histone H3 lysine 9, and Baf60c at the Nkx2.5 cardiac enhancer region by the chromatin immunoprecipitation quantitative polymerase chain reaction assay.	Lysine	97-103	NK2 homeobox 5	Homo sapiens	125-131
26451043-11	2015	Importantly, we show that H2B Lys-123 ubiquitination blocks Jhd2 from accessing its binding site on chromatin, and thereby, we have uncovered a second mechanism by which H2B ubiquitination contributes to the trans-histone regulation of H3K4 methylation.	Lysine	30-33	histone demethylase	Saccharomyces cerevisiae S288C	60-64
26416890-1	2015	The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood.	Lysine	96-99	BRCA1 associated protein 1	Homo sapiens	46-50
26416890-1	2015	The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood.	Lysine	96-99	BRCA1 associated protein 1	Homo sapiens	148-152
27066571-6	2015	CONCLUSIONS: This novel L1CAM mutation was located in the protein"s sixth immunoglobin domain and involved glycine-587, a key residue in the structure of L1CAM because of its interactions with lysine-606, which indicates that any mutation at this site would likely affect the secondary structure and function of the protein.	Lysine	193-199	L1 cell adhesion molecule	Homo sapiens	154-159
26586442-1	2015	The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnover.	Lysine	143-149	H2A.Z variant histone 1	Mus musculus	20-25
26580206-0	2015	Seed-Specific Expression of the Arabidopsis AtMAP18 Gene Increases both Lysine and Total Protein Content in Maize.	Lysine	72-78	microtubule-associated protein 18	Arabidopsis thaliana	44-51
26580206-3	2015	AtMAP18 from Arabidopsis thaliana encoding a microtubule-associated protein with high-lysine content was introduced into the maize genome with the seed-specific promoter F128.	Lysine	86-92	microtubule-associated protein 18	Arabidopsis thaliana	0-7
27066571-6	2015	CONCLUSIONS: This novel L1CAM mutation was located in the protein"s sixth immunoglobin domain and involved glycine-587, a key residue in the structure of L1CAM because of its interactions with lysine-606, which indicates that any mutation at this site would likely affect the secondary structure and function of the protein.	Lysine	193-199	L1 cell adhesion molecule	Homo sapiens	24-29
26424790-5	2015	Chemical inhibitor and siRNA knockdown studies show that EZH2, a histone methyltransferase that catalyzes trimethylation of histone 3 lysine 27 (H3K27me3), suppresses osteogenic differentiation.	Lysine	134-140	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	57-61
26383163-8	2015	Mechanistically, HDAC8 physically interacted with the chromatin modifier EZH2 to concordantly repress Wnt antagonists via histone H4 deacetylation and H3 lysine 27 trimethylation.	Lysine	154-160	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77
26424795-4	2015	Studies presented here demonstrate that CPS1 is a bona fide nuclear protein involved in homocitrullination (hcit), including a key lysine residue on histone H1 (H1K34hcit).	Lysine	131-137	chloride intracellular channel 4	Homo sapiens	157-159
26424795-4	2015	Studies presented here demonstrate that CPS1 is a bona fide nuclear protein involved in homocitrullination (hcit), including a key lysine residue on histone H1 (H1K34hcit).	Lysine	131-137	chloride intracellular channel 4	Homo sapiens	161-170
26807165-2	2015	To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs).	Lysine	33-39	keratin 20	Homo sapiens	95-98
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Lysine	137-140	N-terminal Xaa-Pro-Lys N-methyltransferase 1	Homo sapiens	46-51
26505788-1	2015	Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53.	Lysine	99-105	tumor protein p53	Homo sapiens	229-232
26503055-3	2015	Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCL10, and subsequently determine effector T-cell trafficking to the tumour microenvironment.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	60-89
26580594-4	2015	EZH2 (Enhancer of Zeste Homolog 2) belongs to the Polycomb repressive complex 2 as its catalytic subunit, which through the trimethylation of H3 (Histone 3) on K27 (Lysine 27), produces gene silencing.	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
26580594-4	2015	EZH2 (Enhancer of Zeste Homolog 2) belongs to the Polycomb repressive complex 2 as its catalytic subunit, which through the trimethylation of H3 (Histone 3) on K27 (Lysine 27), produces gene silencing.	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-33
26580594-4	2015	EZH2 (Enhancer of Zeste Homolog 2) belongs to the Polycomb repressive complex 2 as its catalytic subunit, which through the trimethylation of H3 (Histone 3) on K27 (Lysine 27), produces gene silencing.	Lysine	165-171	H3 clustered histone 14	Homo sapiens	142-155
26503055-3	2015	Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCL10, and subsequently determine effector T-cell trafficking to the tumour microenvironment.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	91-95
26460283-7	2015	This library of lysine-conjugated dendrimers showed the ability to efficiently capture the pesticide dichlorvos, confirming the potential of dendrimer-based antidotes to maintain acetylcholinesterase activity in response to poisoning events.	Lysine	16-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	179-199
26349783-4	2015	SUV39H1 is an important methyl-transferase for lysine 9 on histone H3 and usually related to gene transcriptional suppression, and chaetocin acts as the inhibitor of SUV39H1.	Lysine	47-53	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
26549758-4	2015	Loss of Ikaros in CD4(-)CD8(-) cells leads to reduced histone H3 lysine 27 trimethylation and ectopic gene expression.	Lysine	65-71	CD4 molecule	Homo sapiens	18-21
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	transforming growth factor beta 1	Homo sapiens	163-172
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	transforming growth factor beta 1	Homo sapiens	237-246
26553048-3	2015	We examined the role of chromatin markers such as histone H3 lysine methylation (H3Kme) in TGFbeta1-induced TGFBIp and ECM gene expression in normal and GCD2-derived human corneal fibroblasts.	Lysine	61-67	transforming growth factor beta 1	Homo sapiens	91-99
26553291-1	2015	BACKGROUND: The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3).	Lysine	129-135	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	16-43
26553291-1	2015	BACKGROUND: The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3).	Lysine	129-135	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-49
26449473-4	2015	We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm.	Lysine	71-77	lysine (K)-specific demethylase 1A	Mus musculus	99-104
26449473-4	2015	We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm.	Lysine	71-77	lysine (K)-specific demethylase 1A	Mus musculus	120-124
26227335-4	2015	We will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysine methylation and other PTMs in regulating the functions of the modified proteins.	Lysine	140-146	tumor protein p53	Homo sapiens	12-15
26149578-6	2015	Real-time PCR results suggests that the decrease in carboxypeptidase B transcription level might be partially responsible for the increased lysine variant level at sub-physiological temperatures.	Lysine	140-146	carboxypeptidase B	Cricetulus griseus	52-70
26162799-0	2015	PSMA PET/CT with Glu-urea-Lys-(Ahx)-[68Ga(HBED-CC)] versus 3D CT volumetric lymph node assessment in recurrent prostate cancer.	Lysine	26-29	folate hydrolase 1	Homo sapiens	0-4
26162799-2	2015	The purpose of this retrospective investigation was to evaluate the volume and dimensions of nodes identified by Glu-urea-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA-11) in the setting of recurrent prostate cancer.	Lysine	122-125	folate hydrolase 1	Homo sapiens	158-162
25788534-5	2015	Integrating genome-wide GRHL2 binding as well as H3 lysine 4 trimethylation chromatin immunoprecipitation sequencing and gene expression data allowed us to derive a high-confidence GRHL2 target set.	Lysine	52-58	grainyhead like transcription factor 2	Mus musculus	181-186
26319152-7	2015	Moreover, we have identified the lysine 206 of HSF4 as the key residue for ubiquitination.	Lysine	33-39	heat shock transcription factor 4	Homo sapiens	47-51
25788534-4	2015	Molecular analyses showed that GRHL2 acts as a transcriptional activator and strongly associates with histone H3 lysine 4 trimethylation.	Lysine	113-119	grainyhead like transcription factor 2	Mus musculus	31-36
26342977-3	2015	Milk protein yield was stimulated by EAA infusion and returned to saline levels upon subtraction of BCAA, Leu, or Lys.	Lysine	114-117	Weaning weight-maternal milk	Bos taurus	0-4
26303527-2	2015	Acetylation is controlled by complexes containing opposing lysine and histone acetyltransferase (KAT and HAT) and deacetylase (KDAC and HDAC) activities.	Lysine	59-65	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	97-100
26382650-4	2015	In vitro Lpt1p assays with amino acid modifying agents implicated aspartate, glutamate, and lysine as active site residues.	Lysine	92-98	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	9-14
26382650-6	2015	Aligning the primary structures of functionally characterized LPT1 homologs from fungi, plants, and animals identified 11 conserved aspartate, glutamate, lysine, threonine, and tyrosine residues.	Lysine	154-160	lysophospholipid acyltransferase	Saccharomyces cerevisiae S288C	62-66
26370508-0	2015	Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.	Lysine	11-17	X (inactive)-specific transcript, opposite strand	Mus musculus	87-91
26370508-5	2015	Here, we identified histone H3 lysine 36 trimethylation (H3K36me3) as a modification that is recruited by Tsix cotranscriptionally and extends over the Xist promoter.	Lysine	31-37	X (inactive)-specific transcript, opposite strand	Mus musculus	106-110
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Lysine	61-67	sirtuin 1	Rattus norvegicus	22-28
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Lysine	61-67	synaptotagmin 1	Rattus norvegicus	54-57
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Lysine	94-100	sirtuin 1	Rattus norvegicus	22-28
26396186-4	2015	Instead, UCH37, but not a catalytically dead mutant, decreases the Lys-63-linked ubiquitination of E2F1 and activates its transcriptional activity.	Lysine	67-70	ubiquitin C-terminal hydrolase L5	Homo sapiens	9-14
26396186-11	2015	These results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63-linked ubiquitination by UCH37.	Lysine	99-102	ubiquitin C-terminal hydrolase L5	Homo sapiens	131-136
26207449-3	2015	This study found, using amide hydrogen/deuterium (H/D) exchange, capillary electrophoresis, and lysine-acetyl protein charge ladders, that ALS-linked A4V SOD1 rapidly monomerizes and partially unfolds in an external electric field (of physiological strength), without loss of metal ions, exposure to disulfide-reducing agents, or Joule heating.	Lysine	96-102	superoxide dismutase 1	Homo sapiens	139-142
26207449-3	2015	This study found, using amide hydrogen/deuterium (H/D) exchange, capillary electrophoresis, and lysine-acetyl protein charge ladders, that ALS-linked A4V SOD1 rapidly monomerizes and partially unfolds in an external electric field (of physiological strength), without loss of metal ions, exposure to disulfide-reducing agents, or Joule heating.	Lysine	96-102	superoxide dismutase 1	Homo sapiens	154-158
26276392-7	2015	In addition, phenformin prevented IL-4-induced association of STAT6 and Lys-9 acetylation of histone H3 at the ALOX15 promoter.	Lysine	72-75	interleukin 4	Homo sapiens	34-38
26431949-2	2015	We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections.	Lysine	31-37	lysine demethylase 6A	Homo sapiens	13-16
26268241-8	2015	Ectopic expression of IDH2(R172K) in the Jurkat cell line and CD4(+) T cells led to markedly increased levels of 2-hydroxyglutarate, histone-3 lysine methylation, and 5-methylcytosine and a decrease of 5-hydroxymethylcytosine.	Lysine	143-149	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	22-26
26213324-9	2015	CHIP analyses of H3 (Lys 9/14) acetylation of ovary specific CYP19A1 proximal promoter (PII) showed that TSA pre-treatment prevented the LPS mediated H3 deacetylation, thereby increased the acetylation of PII and restored CYP19A1 expression and E2 production.	Lysine	21-24	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	61-68
26460970-7	2015	Last, we report the proof-of-principle validation of two lysine residues required for nSyb ubiquitination.	Lysine	57-63	neuronal Synaptobrevin	Drosophila melanogaster	86-90
26448330-0	2015	Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.	Lysine	14-20	heat shock protein family A (Hsp70) member 1A	Homo sapiens	7-12
26448330-4	2015	A recent study used an antibody-based approach to investigate the methylation of Lys-561 of the stress-inducible Hsp70 protein HSPA1, focusing exclusively on dimethylated HSPA1, concluding that it was elevated in cancer [Cho et al.	Lysine	81-84	heat shock protein family A (Hsp70) member 1A	Homo sapiens	127-132
26448330-14	2015	In conclusion, lysine methylation of HSPA1 differs between metastatic breast and ovarian carcinoma, and unmethylated HSPA1 shows potential as a prognostic marker in high-grade serous carcinoma.	Lysine	15-21	heat shock protein family A (Hsp70) member 1A	Homo sapiens	37-42
26296461-1	2015	SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase that methylates lysine 9 on histone H3.	Lysine	81-87	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	26-32
26435321-8	2015	These results indicate that lysine methylation by SETD7 is important for the fine-tuning of ROS signaling through its regulation on pro-inflammatory responses, mitochondrial function and the NFE2L2/ARE pathway.	Lysine	28-34	NFE2 like bZIP transcription factor 2	Homo sapiens	191-197
26276392-7	2015	In addition, phenformin prevented IL-4-induced association of STAT6 and Lys-9 acetylation of histone H3 at the ALOX15 promoter.	Lysine	72-75	arachidonate 15-lipoxygenase	Homo sapiens	111-117
26381711-8	2015	Because the biochemical characteristics of lysine are similar to arginine, we assumed that p.Arg2508Lys RYR1 would have characteristics most similar to those of the wild-type RYR1.	Lysine	43-49	ryanodine receptor 1	Homo sapiens	104-108
26431207-5	2015	CUL4A-DDB1-CDT2 E3 ligase targets lysine 585 within the C-terminal region of CRY1 protein, shown by the CRY1 585KA mutant"s resistance to ubiquitination and degradation mediated by the CUL4A-DDB1 complex.	Lysine	34-40	cullin 4A	Homo sapiens	0-10
26431207-5	2015	CUL4A-DDB1-CDT2 E3 ligase targets lysine 585 within the C-terminal region of CRY1 protein, shown by the CRY1 585KA mutant"s resistance to ubiquitination and degradation mediated by the CUL4A-DDB1 complex.	Lysine	34-40	cullin 4A	Homo sapiens	185-195
26507377-5	2015	We recently reported that lysine-acetylation regulates nearly all aspects of Ran-function such as RCC1 catalyzed nucleotide exchange, intrinsic nucleotide hydrolysis, its interaction with NTF2 and the formation of import- and export-complexes.	Lysine	26-32	regulator of chromosome condensation 1	Homo sapiens	98-102
26224785-9	2015	Mutagenesis of these lysines to leucines abolished protein disulfide isomerase heterodimerization, lipid transfer, and apoB secretion, without affecting apoB17 binding.	Lysine	21-28	apolipoprotein B	Homo sapiens	119-123
26722485-1	2015	KDM4A, KDM4B and KDM4D are lysine demethylases which demethylate H3 at lysine K9 and K36 sites, additionally KDM4D also the H1.4 linker histone at K26 lysine.	Lysine	27-33	lysine demethylase 4B	Homo sapiens	7-12
26253504-3	2015	In an alternative approach, the number of reactive groups per macromonomer was increased by branching the terminal ends of eight-armed PEG with lysine (Lys) and Ahx residues (8armPEG20k-Lys-Ahx-Fur2 and 8armPEG20k-Lys-Ahx-Mal2).	Lysine	144-150	nuclear receptor subfamily 0 group B member 1	Homo sapiens	190-193
26253504-3	2015	In an alternative approach, the number of reactive groups per macromonomer was increased by branching the terminal ends of eight-armed PEG with lysine (Lys) and Ahx residues (8armPEG20k-Lys-Ahx-Fur2 and 8armPEG20k-Lys-Ahx-Mal2).	Lysine	144-150	nuclear receptor subfamily 0 group B member 1	Homo sapiens	190-193
26253504-7	2015	8armPEG20k hydrogels had the largest mesh size of all tested hydrogels, while hydrogels made from dendritic 8armPEG20k-Lys-Ahx macromonomers showed the smallest value.	Lysine	119-122	nuclear receptor subfamily 0 group B member 1	Homo sapiens	123-126
26283540-2	2015	Transcription of CIITA through the IFN-gamma inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2).	Lysine	166-172	interferon gamma	Homo sapiens	35-44
25288139-6	2015	Specifically, deacetylation of histone 3 at lysine 9 (H3K9), through the coordinated action of the NAD+-dependent protein deacetylase sirtuin-6 (SIRT6) and nuclear factor kappa B (NFkappaB), sequesters GR expression leading to disinhibition of CRF.	Lysine	44-50	nuclear factor kappa B subunit 1	Homo sapiens	156-178
25288139-6	2015	Specifically, deacetylation of histone 3 at lysine 9 (H3K9), through the coordinated action of the NAD+-dependent protein deacetylase sirtuin-6 (SIRT6) and nuclear factor kappa B (NFkappaB), sequesters GR expression leading to disinhibition of CRF.	Lysine	44-50	nuclear factor kappa B subunit 1	Homo sapiens	180-188
26183023-2	2015	Previously, we found that p53 interacts with KAISO, and acetylation of p53 lysine residues by p300 is modulated by KAISO.	Lysine	75-81	tumor protein p53	Homo sapiens	71-74
26366928-0	2015	Dietary L-Lysine Suppresses Autophagic Proteolysis and Stimulates Akt/mTOR Signaling in the Skeletal Muscle of Rats Fed a Low-Protein Diet.	Lysine	8-16	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
26366928-9	2015	Taken together, supplementation of Lys to a low-protein diet suppresses autophagic proteolysis through the Akt/mTOR signaling pathway, and continuous feeding of a Lys-rich diet may increase skeletal muscle mass.	Lysine	35-38	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
26337909-5	2015	Recent evidence from our laboratories and others indicates that, in addition to various posttranslational modifications of NF-kappaB that have been observed previously, including phosphorylation, ubiquitination, and acetylation, NF-kappaB can be methylated reversibly on lysine or arginine residues by histone-modifying enzymes, including lysine and arginine methyl transferases and demethylases.	Lysine	271-277	nuclear factor kappa B subunit 1	Homo sapiens	123-132
26337909-5	2015	Recent evidence from our laboratories and others indicates that, in addition to various posttranslational modifications of NF-kappaB that have been observed previously, including phosphorylation, ubiquitination, and acetylation, NF-kappaB can be methylated reversibly on lysine or arginine residues by histone-modifying enzymes, including lysine and arginine methyl transferases and demethylases.	Lysine	271-277	nuclear factor kappa B subunit 1	Homo sapiens	229-238
26219303-7	2015	Chromatin immunoprecipitation-sequence analysis of trimethylation of histone H3 at lysine 27 (H3K27me3) revealed a compensatory function of Ezh1, another enzymatic component of PRC2, in this process.	Lysine	83-89	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	140-144
26047679-8	2015	Mechanistically, miR-584-5p recruited Argonaute 2 to facilitate the enrichment of enhancer of zeste homolog 2, histone H3 lysine 27 trimethylation, and histone H3 lysine 9 dimethylation on MMP-14 promoter in NB cells, which was abolished by repressing the miR-584-5p-promoter interaction.	Lysine	122-128	argonaute RISC catalytic component 2	Homo sapiens	38-49
26047679-8	2015	Mechanistically, miR-584-5p recruited Argonaute 2 to facilitate the enrichment of enhancer of zeste homolog 2, histone H3 lysine 27 trimethylation, and histone H3 lysine 9 dimethylation on MMP-14 promoter in NB cells, which was abolished by repressing the miR-584-5p-promoter interaction.	Lysine	163-169	argonaute RISC catalytic component 2	Homo sapiens	38-49
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Lysine	149-155	cyclin dependent kinase inhibitor 2A	Homo sapiens	63-66
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Lysine	149-155	cyclin dependent kinase inhibitor 2A	Homo sapiens	191-194
26496755-3	2015	Through co-microinjection of Cas9 mRNA and single-guide RNA (sgRNA) targeting genomic DNA sequence corresponding to enzyme activity of lysine (K)-specific demethylase 2b (Kdm2b), both a frame-shifted Kdm2b null mutant and a Kdm2b enzyme activity disrupted mouse strain were obtained simultaneously.	Lysine	135-141	lysine (K)-specific demethylase 2B	Mus musculus	171-176
26405459-5	2015	Unlike other PLZF-interacting deacetylases, these two proteins interact with the zinc finger domain of PLZF, where the activating CBP/p300 acetylation site was previously described, inducing deacetylation of lysines 647/650/653.	Lysine	208-215	CREB binding protein	Homo sapiens	130-133
26116825-5	2015	We then identified a previously undescribed nuclear export sequence in PPARalpha, along with three specific lysines (292, 310, 388) required for MuRF1"s targeting of nuclear export.	Lysine	108-115	tripartite motif containing 63	Homo sapiens	145-150
26365310-4	2015	In our functional assays, LRRK2 binds to focal adhesion kinase (FAK) and phosphorylates its Thr-X-Arg/Lys (TXR/K) motif(s), eventually attenuating FAK activity marked by decreased pY397 phosphorylation (pY397).	Lysine	102-105	leucine rich repeat kinase 2	Homo sapiens	26-31
26241673-8	2015	We found that corin truncation mutants lacking a Lys-Phe-Gln sequence at residues 71-73 had higher levels of cell surface expression and activation compared with that in wild-type corin.	Lysine	49-52	corin, serine peptidase	Mus musculus	14-19
26241673-8	2015	We found that corin truncation mutants lacking a Lys-Phe-Gln sequence at residues 71-73 had higher levels of cell surface expression and activation compared with that in wild-type corin.	Lysine	49-52	corin, serine peptidase	Mus musculus	180-185
26241673-9	2015	When Lys-71, Phe-72 and Gln-73 residues were mutated together, but not individually, in corin with the full-length cytoplasmic tail, increased levels of cell surface expression and zymogen activation were also observed.	Lysine	5-8	corin, serine peptidase	Mus musculus	88-93
26241673-10	2015	These results indicate that residues Lys-71, Phe-72 and Gln-73 serve as a novel retention motif in the intracellular pathway to regulate corin cell surface expression and activation.	Lysine	37-40	corin, serine peptidase	Mus musculus	137-142
26188511-7	2015	SUMOylation occurs primarily at K402, and mutation of the SUMO consensus site surrounding this lysine reduces Ago2-mediated siRNA-induced silencing in a luciferase-based reporter assay.	Lysine	95-101	argonaute RISC catalytic component 2	Homo sapiens	110-114
26734704-2	2015	Recent studies show that a unique dimethylation of lysine 4 residue on histone 3 (H3K4me2) distribution pattern around transcription starting sites (TSS) of genes marks tissue specific genes in human CD4 th T cells and mouse nervous tissue cells.	Lysine	51-57	CD4 molecule	Homo sapiens	200-203
26092122-1	2015	WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3.	Lysine	91-97	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
26160163-1	2015	SETDB1, a histone methyltransferase responsible for methylation of histone H3 lysine 9 (H3K9), is involved in maintenance of embryonic stem (ES) cells and early embryonic development of the mouse.	Lysine	78-84	SET domain, bifurcated 1	Mus musculus	0-6
26160163-6	2015	Genetic deletion of Setdb1 reduced EZH2 binding as well as histone 3 lysine 27 (H3K27) trimethylation level at SETDB1 solo peaks and facilitated neural differentiation.	Lysine	69-75	SET domain, bifurcated 1	Mus musculus	20-26
26622943-8	2015	Our study demonstrates the importance of acetylated lysine residues and suggests their key role in regulating MeCP2 function and its ability to bind transcriptional regulators.	Lysine	52-58	methyl-CpG binding protein 2	Homo sapiens	110-115
26280580-2	2015	Dominant mutations in the chromatin regulators lysine (K)-specific methyltransferase 2D (KMT2D) (also known as MLL2) and lysine (K)-specific demethylase 6A (KDM6A) underlie the majority of cases.	Lysine	47-53	lysine demethylase 6A	Homo sapiens	121-155
26356136-4	2015	Corresponding [(18)F]SFB-labeled PTH derivatives were prepared respectively and the Lys(13) site-specific labeled [(18)F]FBz PTH was isolated by HPLC with radiochemical purity &gt;99% and specific activity of 2.78 GBq/micromol, suitable for future application with in vivo pharmacokinetic/pharmacodynamic studies of PTH, using preclinical Positron Emission Tomography Computed Tomography (PET/CT) imaging.	Lysine	84-87	parathyroid hormone	Homo sapiens	125-128
26356136-4	2015	Corresponding [(18)F]SFB-labeled PTH derivatives were prepared respectively and the Lys(13) site-specific labeled [(18)F]FBz PTH was isolated by HPLC with radiochemical purity &gt;99% and specific activity of 2.78 GBq/micromol, suitable for future application with in vivo pharmacokinetic/pharmacodynamic studies of PTH, using preclinical Positron Emission Tomography Computed Tomography (PET/CT) imaging.	Lysine	84-87	parathyroid hormone	Homo sapiens	125-128
26244656-7	2015	Using two mass spectrometry-based strategies (matrix-assisted laser desorption ionization time of flight and electrospray ionization liquid chromatography with tandem mass spectrometry), lysine 37 was identified as a SUMO-1-modified residue by both methods.	Lysine	187-193	small ubiquitin-like modifier 1	Mus musculus	217-223
26149390-5	2015	Interestingly, knockdown of ARTD1 did not alter H3 occupancy but increased LPS-induced trimethylation of histone 3 at lysine 4 (H3K4me3), a hallmark of transcriptionally active genes.	Lysine	118-124	poly(ADP-ribose) polymerase 1	Homo sapiens	28-33
25820690-4	2015	We aimed to determine the levels of trimethylated histone 3 at lysine residue 27 (H3K27me3), a well-known repressive mark, by immunoassay of fresh tissues and immunohistochemistry (IHC) of an endometriosis-focused tissue microarray.	Lysine	63-69	microtubule affinity regulating kinase 1	Homo sapiens	117-121
26141949-6	2015	Cells expressing Thr150Ala/Ser159Ala-mutant SIRT3 show a reduction in mitochondrial protein lysine deacetylation, Deltapsim, MnSOD activity, and mitochondrial ATP generation.	Lysine	92-98	sirtuin 3	Homo sapiens	44-49
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Lysine	52-55	amyloid beta precursor protein	Homo sapiens	192-196
26291311-2	2015	Here, we demonstrate that SOX4 acetylation at lysine 95 by KAT5 (also known as Tip60) is essential for Cald1 promoter activity at the onset of C2C12 myoblast differentiation.	Lysine	46-52	caldesmon 1	Homo sapiens	103-108
26008972-0	2015	Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents.	Lysine	15-21	superoxide dismutase 1	Homo sapiens	37-59
26008972-3	2015	In this study, we have discovered that superoxide dismutase 1 (SOD1), a major player in maintaining the cellular redox status, was acetylated at lysine 71.	Lysine	145-151	superoxide dismutase 1	Homo sapiens	39-61
26008972-3	2015	In this study, we have discovered that superoxide dismutase 1 (SOD1), a major player in maintaining the cellular redox status, was acetylated at lysine 71.	Lysine	145-151	superoxide dismutase 1	Homo sapiens	63-67
26609482-2	2015	Transglutaminase 2 (TG2, EC 2.3.2.13), a multi-functional enzyme that catalyzes the formation of intermolecular isopeptide bonds between glutamine and lysine side-chains, has been reported to exert important pathophysiological functions.	Lysine	151-157	transglutaminase 2	Homo sapiens	0-18
26295410-0	2015	Dichotomy in the Epigenetic Mark Lysine Acetylation is Critical for the Proliferation of Prostate Cancer Cells.	Lysine	33-39	microtubule affinity regulating kinase 1	Homo sapiens	28-32
26295410-1	2015	The dynamics of lysine acetylation serve as a major epigenetic mark, which regulates cellular response to inflammation, DNA damage and hormonal changes.	Lysine	16-22	microtubule affinity regulating kinase 1	Homo sapiens	63-67
26609488-1	2015	DOT1L is a unique histone methyltransferase that targets the histone H3 lysine 79 (H3K79) residue for mono-, di- and tri- methylation.	Lysine	72-78	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
26609482-2	2015	Transglutaminase 2 (TG2, EC 2.3.2.13), a multi-functional enzyme that catalyzes the formation of intermolecular isopeptide bonds between glutamine and lysine side-chains, has been reported to exert important pathophysiological functions.	Lysine	151-157	transglutaminase 2	Homo sapiens	20-23
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	cytochrome P450, family 4, subfamily a, polypeptide 14	Mus musculus	89-96
26268310-2	2015	EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	peroxisome proliferator activated receptor alpha	Mus musculus	118-123
26267652-7	2015	Changes at histone-3 lysine-27 acetylation (H3K27ac) marks were detected at genes Fasn, Nr3c1, and Plin5.	Lysine	21-27	fatty acid synthase	Mus musculus	82-86
26267652-7	2015	Changes at histone-3 lysine-27 acetylation (H3K27ac) marks were detected at genes Fasn, Nr3c1, and Plin5.	Lysine	21-27	nuclear receptor subfamily 3, group C, member 1	Mus musculus	88-93
26111449-3	2015	Together with another essential core component, SUZ12, EZH2 trimethylates histone H3 on lysine 27 (H3K27me3).	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	55-59
26265454-1	2015	The enhancer of zeste homolog 2 (EZH2) methyltransferase is the catalytic subunit of polycomb repressive complex 2 (PRC2), which acts as a transcription repressor via the trimethylation of lysine 27 of histone 3 (H3K27me3).	Lysine	189-195	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
26265454-1	2015	The enhancer of zeste homolog 2 (EZH2) methyltransferase is the catalytic subunit of polycomb repressive complex 2 (PRC2), which acts as a transcription repressor via the trimethylation of lysine 27 of histone 3 (H3K27me3).	Lysine	189-195	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	nuclear receptor subfamily 3, group C, member 1	Mus musculus	105-110
25936293-0	2015	Frequency of the MSTN Lys(K)-153Arg(R) polymorphism among track &amp; field athletes and swimmers.	Lysine	22-25	myostatin	Homo sapiens	17-21
26061139-4	2015	Treatment of dairy cow mammary epithelial cells with amino acids (lysine or methionine) increased both cell growth and the expression of beta-casein (CSN2), WISP3, mTOR, and phospho-mTOR (p-mTOR).	Lysine	66-72	casein beta	Bos taurus	150-154
26100207-7	2015	The NMR resonances of Lys (177, 178, 179), Gly182, and Ser183 in the C1 region and Lys193 and Lys194 in the V region of syndecan-4 are perturbed upon syndesmos binding.	Lysine	22-25	nudix hydrolase 16 like 1	Homo sapiens	150-159
25936293-3	2015	PURPOSE: The aim of the present study was to assess the frequency of the MSTN Lys(K)-153Arg(R) polymorphism among Israeli track and field athletes (n=185) and swimmers (n=80).	Lysine	78-81	myostatin	Homo sapiens	73-77
26024947-2	2015	Sirtuin deacetylases remove acetyl groups from modified lysine residues, and sirtuin 3 (SIRT3) has been identified as a target for cancer therapeutics.	Lysine	56-62	sirtuin 3	Homo sapiens	77-86
26024947-2	2015	Sirtuin deacetylases remove acetyl groups from modified lysine residues, and sirtuin 3 (SIRT3) has been identified as a target for cancer therapeutics.	Lysine	56-62	sirtuin 3	Homo sapiens	88-93
26002909-5	2015	Notably, GCN5-mediated acetylation of histone 3 lysine 9 and histone 3 lysine 14 of FERRIC REDUCTASE DEFECTIVE3 (FRD3) determined the dynamic expression of FRD3.	Lysine	48-54	MATE efflux family protein	Arabidopsis thaliana	156-160
26023067-3	2015	In this study, we report the construction of fragment ion library for Amadori-modified lysine (AML), N(epsilon)-(carboxymethyl)lysine (CML)-, and N(epsilon)-(carboxyethyl)lysine (CEL)-modified peptides of the corresponding synthetically modified albumin using high resolution accurate mass spectrometry (HR/AM).	Lysine	87-93	albumin	Homo sapiens	246-253
26166030-3	2015	Interaction between the EDNRB promoter region and histone H3 lysine 9 trimethylation (H3K9me3) was examined using chromatin immunoprecipitation (ChIP) in combination with ChIP-polymerase chain reaction (ChIP-PCR).	Lysine	61-67	endothelin receptor type B	Homo sapiens	24-29
26306316-5	2015	While it was shown that fibronectin greatly affects the expression of tumor-produced factors associated with bone destruction (parathyroid hormone-related protein, PTHrP, and Gli2), poly-l-lysine, vitronectin and type I collagen were also analyzed as potential matrix proteins.	Lysine	182-195	fibronectin 1	Homo sapiens	24-35
25694334-7	2015	This lysine conjugate is currently being considered for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, and combines the anti-HER2 antibody trastuzumab (Herceptin( )), with the cytotoxic microtubule-inhibiting maytansine derivative, DM1.	Lysine	5-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-113
25694334-7	2015	This lysine conjugate is currently being considered for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, and combines the anti-HER2 antibody trastuzumab (Herceptin( )), with the cytotoxic microtubule-inhibiting maytansine derivative, DM1.	Lysine	5-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-119
26199140-3	2015	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.	Lysine	108-114	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
26199140-3	2015	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.	Lysine	108-114	snail family transcriptional repressor 1	Homo sapiens	17-22
26189595-0	2015	Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	Lysine	83-89	mitogen-activated protein kinase 8	Homo sapiens	126-129
26189595-0	2015	Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	Lysine	83-89	mitogen-activated protein kinase 14	Homo sapiens	134-137
25903134-6	2015	Together with structural docking studies, our data suggest that FVIII interacts with LRP1 via an extended surface of multiple lysine residues that starts at the bottom of the C1 domain and winds around the FVIII molecule.	Lysine	126-132	LDL receptor related protein 1	Homo sapiens	85-89
26038984-0	2015	A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch.	Lysine	49-55	cytochrome c, somatic	Homo sapiens	23-35
26038984-7	2015	Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cyt c that has enhanced peroxidase activity, adding support for a role of the Lys-ligated cyt c in the apoptotic mechanism.	Lysine	71-74	cytochrome c, somatic	Homo sapiens	83-88
26038984-7	2015	Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cyt c that has enhanced peroxidase activity, adding support for a role of the Lys-ligated cyt c in the apoptotic mechanism.	Lysine	71-74	cytochrome c, somatic	Homo sapiens	173-178
26038984-7	2015	Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cyt c that has enhanced peroxidase activity, adding support for a role of the Lys-ligated cyt c in the apoptotic mechanism.	Lysine	161-164	cytochrome c, somatic	Homo sapiens	83-88
26038984-7	2015	Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cyt c that has enhanced peroxidase activity, adding support for a role of the Lys-ligated cyt c in the apoptotic mechanism.	Lysine	161-164	cytochrome c, somatic	Homo sapiens	173-178
25903134-3	2015	Using coagulation factor VIII as a model ligand, we now study the contribution of individual lysine residues in the interaction with the largest member of the LDL receptor family, low-density lipoprotein receptor-related protein (LRP1).	Lysine	93-99	LDL receptor related protein 1	Homo sapiens	230-234
25545350-0	2015	Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.	Lysine	29-35	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	10-20
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	106-112	LDL receptor related protein 1	Homo sapiens	233-237
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	290-296	LDL receptor related protein 1	Homo sapiens	233-237
26140605-3	2015	Here, we show that TPO promotes metastasis of CD110+ TICs to the liver by activating lysine degradation.	Lysine	85-91	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	46-51
26140605-6	2015	Lysine catabolism also generates glutamate, which modulates the redox status of CD110+ TICs to promote liver colonization and drug resistance.	Lysine	0-6	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	80-85
25581111-8	2015	Treatment only for patients at stages F3-F4 with IFN-free therapies would increase LYS by 16.7% versus SE0 in Egypt, 22.0% versus ST0 in Thailand, and 13.1% versus SC0 in Cote d"Ivoire.	Lysine	83-86	interferon alpha 1	Homo sapiens	49-52
25545350-5	2015	Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression.	Lysine	19-25	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	109-119
25545350-5	2015	Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression.	Lysine	19-25	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	160-166
25545350-5	2015	Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression.	Lysine	19-25	cytochrome P450 family 8 subfamily B member 1	Homo sapiens	171-177
25545350-5	2015	Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression.	Lysine	19-25	solute carrier family 10 member 1	Homo sapiens	213-217
25998860-6	2015	The enhancer of zeste homolog 2 (EZH2) is a methyltransferase which catalyzes lysine 27 methylation in histone H3 resulting in suppression of target gene expression.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
26373048-4	2015	The residues, Lys, Phe and Thr contribute significantly to the adsorption of cytochrome c to graphene.	Lysine	14-17	cytochrome c, somatic	Homo sapiens	77-89
26373048-5	2015	The long hydrophobic and flexible alkyl tail of Lys, the pi-pi stacking interaction between Phe and graphene, and the presence of abundant Thr constitute the driving force for the stable adsorption of cytochrome c on graphene.	Lysine	48-51	cytochrome c, somatic	Homo sapiens	201-213
25878105-4	2015	Three ASYMP CD8(+) T-cell epitopes (gD(53-61), gD(70-78), and gD(278-286)) were linked with a promiscuous CD4(+) T-cell epitope (gD(287-317)) to create 3 separate pairs of CD4-CD8 peptides, which were then each covalently coupled to an Nepsilon-palmitoyl-lysine moiety, a Toll-like receptor 2 (TLR-2) ligand.	Lysine	255-261	CD4 molecule	Homo sapiens	106-109
25695204-8	2015	Following treatment of the Colo205 and HT-29 CRC cell lines, with the EZH2 inhibitor, GSK126, the level of histone H3 lysine 27 trimethylation (H3K27me3) was reduced and the mRNA and protein expression levels of CLDN23 were increased.	Lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	70-74
25695204-10	2015	Furthermore, ChIP analysis of these samples detected histone H3 lysine 4 trimethylation (H3K4me3) at the CLDN23 promoter, demonstrating that the balance between H3K27me3 and H3K4me3 may underlie the regulation of the expression of CLDN23.	Lysine	64-70	claudin 23	Homo sapiens	105-111
25998860-6	2015	The enhancer of zeste homolog 2 (EZH2) is a methyltransferase which catalyzes lysine 27 methylation in histone H3 resulting in suppression of target gene expression.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
25998860-7	2015	The histone demethylase JMJD3 opposes the activity of EZH2 by demethylating histone H3 lysine 27.	Lysine	87-93	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
26104385-2	2015	DNA methylation, catalyzed by DNA methyl transferases (DNMTs), and tri-methylation of lysine 27 on histone H3 (H3K27me3), mediated by the methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), are some of the most commonly found modifications in epigenetics.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	157-184
25755154-6	2015	Specifically, we asked whether Ctm1p-mediated trimethylation of yeast cytochrome c Cyc1p, on lysine 78, modulates its interactions with Erv1p, Ccp1p, Cyc2p and Cyc3p.	Lysine	93-99	cytochrome c lysine N-methyltransferase	Saccharomyces cerevisiae S288C	31-36
26131334-3	2015	To our knowledge, phosphorylation of upstream with-no-lysine (K) (WNK) kinases would activate SPAK kinases.	Lysine	54-60	serine/threonine kinase 39	Homo sapiens	94-98
26030124-5	2015	Here, we examined the effect of a novel protein assembly modulator, the lysine (Lys)-specific molecular tweezer, CLR01, on different aggregation stages of misfolded mutant p53 in vitro and on the cytotoxicity of the resulting p53 aggregates in cell culture.	Lysine	72-78	tumor protein p53	Homo sapiens	172-175
26100532-9	2015	RESULTS: Pre- or post-treatment with L-lysine led to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p &lt; 0.001).	Lysine	37-45	catalase	Mus musculus	233-241
26100532-11	2015	CONCLUSIONS: L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity.	Lysine	13-21	interleukin 6	Mus musculus	145-149
26030124-5	2015	Here, we examined the effect of a novel protein assembly modulator, the lysine (Lys)-specific molecular tweezer, CLR01, on different aggregation stages of misfolded mutant p53 in vitro and on the cytotoxicity of the resulting p53 aggregates in cell culture.	Lysine	80-83	tumor protein p53	Homo sapiens	172-175
26104385-2	2015	DNA methylation, catalyzed by DNA methyl transferases (DNMTs), and tri-methylation of lysine 27 on histone H3 (H3K27me3), mediated by the methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), are some of the most commonly found modifications in epigenetics.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	186-190
26182435-9	2015	Furthermore, Bcnt/Cfdp1 is acetylated in vitro by CREB-binding protein (CBP) and four lysine residues including Lys(268) in BCNT-C are also acetylated in vivo, revealing a protein regulated at multiple levels.	Lysine	112-115	craniofacial development protein 1	Homo sapiens	13-17
25969923-4	2015	ALP is simply conjugated to a ZFP through lysine residues in a ZFP purification tag, a maltose binding protein (MBP).	Lysine	42-48	alkaline phosphatase, placental	Homo sapiens	0-3
26004508-4	2015	The lysine residues within this region are required for the methylation of non-phosphorylated beta-catenin, which is demethylated by Kdm2a/b and subsequently ubiquitylated.	Lysine	4-10	catenin beta 1 L homeolog	Xenopus laevis	94-106
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	0-3	mitogen-activated protein kinase 3	Homo sapiens	89-95
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	130-133	mitogen-activated protein kinase 3	Homo sapiens	89-95
25408501-6	2015	A mutational analysis identified the lysine residue on BAK required for proteolysis, and a functional siRNA screen identified the HECT domain E3 ubiquitin ligase HERC1 as being required for E6-mediated BAK degradation.	Lysine	37-43	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	Homo sapiens	162-167
26182435-9	2015	Furthermore, Bcnt/Cfdp1 is acetylated in vitro by CREB-binding protein (CBP) and four lysine residues including Lys(268) in BCNT-C are also acetylated in vivo, revealing a protein regulated at multiple levels.	Lysine	112-115	craniofacial development protein 1	Homo sapiens	124-128
25862515-5	2015	Urate oxidase (Uox), a therapeutic enzyme for treatment of hyperuricemia, is a homotetramer with multiple surface lysines, limiting conventional approaches for albumination.	Lysine	114-121	urate oxidase	Mus musculus	0-13
25862515-5	2015	Urate oxidase (Uox), a therapeutic enzyme for treatment of hyperuricemia, is a homotetramer with multiple surface lysines, limiting conventional approaches for albumination.	Lysine	114-121	urate oxidase	Mus musculus	15-18
25959397-7	2015	Thus, lysine oxidation of the transcription factor TAF10 is a controlled protein modification and demonstrates a role for protein oxidation in regulating pluripotency genes.	Lysine	6-12	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor	Danio rerio	51-56
26061460-7	2015	Interestingly, USP15 specifically removed lysine 63-linked polyubiquitin chains from RIG-I among the essential components in RIG-I-like receptor-dependent pathway.	Lysine	42-48	ubiquitin specific peptidase 15	Homo sapiens	15-20
25733201-7	2015	Moreover, insulin sensitizer therapy significantly reduced three functionally clustered AA and metabolite pairs: i) phenylalanine/tyrosine, ii) citrulline/arginine, and iii) lysine/alpha-aminoadipic acid.	Lysine	174-180	insulin	Homo sapiens	10-17
26057801-5	2015	THB1 resembles other TrHb1s, but also exhibits distinct features associated with the coordination of the heme iron by a histidine (proximal) and a lysine (distal).	Lysine	147-153	uncharacterized protein	Chlamydomonas reinhardtii	0-4
25256819-0	2015	Tailoring of the dopamine coated surface with VEGF loaded heparin/poly-L-lysine particles for anticoagulation and accelerate in situ endothelialization.	Lysine	66-79	vascular endothelial growth factor A	Homo sapiens	46-50
25256819-4	2015	In this study, novel VEGF-loaded heparin/poly-L-lysine (Hep/PLL) particles were developed and immobilized on a dopamine coated titanium surface.	Lysine	41-54	vascular endothelial growth factor A	Homo sapiens	21-25
25374384-13	2015	However, xenin-25[Lys(13)PAL] treatment restored notable sensitivity to the biological actions of exogenous GIP injection.	Lysine	18-21	Shc SH2-domain binding protein 1	Mus musculus	25-28
25374384-13	2015	However, xenin-25[Lys(13)PAL] treatment restored notable sensitivity to the biological actions of exogenous GIP injection.	Lysine	18-21	gastric inhibitory polypeptide	Mus musculus	108-111
24865414-7	2015	Biochemical analyses revealed that ESBL producers more frequently utilized inositol, ornithine, sorbitol, melibiose, and saccharose, whereas the control group more frequently used esculin, lysine, arginine, and dulcitol.	Lysine	189-195	EsbL	Escherichia coli	35-39
25855754-3	2015	We demonstrated that SetD8, a histone methyltransferase that catalyzes monomethylation of histone H4 at lysine 20 (H4K20me1), is a context-dependent GATA-1 corepressor in erythroid cells.	Lysine	104-110	lysine methyltransferase 5A	Mus musculus	21-26
25869136-9	2015	Finally, mutation of Glu(615) at the end of the C-terminal alpha-helix to Lys reduced surface expression of SERT-E615K.	Lysine	74-77	solute carrier family 6 member 4	Homo sapiens	108-112
25997738-2	2015	Here, we elucidate the functions of two histone H3 lysine 4 (H3K4) methylation enzymes, SMYD3 and SETD7, during zebrafish heart morphogenesis using gene expression profiling by whole mount in situ hybridization and antisense morpholino oligonucleotide (MO)-based gene knockdown.	Lysine	51-57	SET and MYND domain containing 3	Danio rerio	88-93
25825497-8	2015	LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys(370) at submicromolar concentrations.	Lysine	92-95	tumor protein p53	Homo sapiens	88-91
26014357-6	2015	We ended up with a single model structure where all the lysine residues of cytochrome c that are known as functionally-relevant were involved in forming salt bridges with acidic residues of Apaf-1.	Lysine	56-62	cytochrome c, somatic	Homo sapiens	75-87
26014357-6	2015	We ended up with a single model structure where all the lysine residues of cytochrome c that are known as functionally-relevant were involved in forming salt bridges with acidic residues of Apaf-1.	Lysine	56-62	apoptotic peptidase activating factor 1	Homo sapiens	190-196
26014357-7	2015	This model has revealed three distinctive bifurcated salt bridges, each involving a single lysine residue of cytochrome c and two neighboring acidic resides of Apaf-1.	Lysine	91-97	cytochrome c, somatic	Homo sapiens	109-121
26015494-5	2015	Instead, we found that the levels of a histone-modifying enzyme, SETD1A methyltransferase, and histone H3 lysine 4 trimethylation were reduced on IE and early (E) gene promoters in BAF-depleted cells during HSV lytic infection.	Lysine	106-112	BAF nuclear assembly factor 1	Homo sapiens	181-184
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	58-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-152
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	86-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-152
25897119-8	2015	These findings define a novel modification of HIF-1alpha/2alpha and demonstrate that Set7-medited lysine methylation negatively regulates HIF-alpha transcriptional activity and HIF-1alpha-mediated glucose homeostasis.	Lysine	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-63
25978433-2	2015	Methylation of lysine 9 on histone H3 by the methyltransferase G9a and SUV39H1 is associated with inhibition of tumor suppressor genes.	Lysine	15-21	SUV39H1 histone lysine methyltransferase	Homo sapiens	71-78
25996949-11	2015	Likewise, LMP1 or TRAF1 complexes purified from LCLs were decorated by lysine 63 (K63)-linked polyubiqutin chains.	Lysine	71-77	TNF receptor associated factor 1	Homo sapiens	18-23
25728577-1	2015	Tandem mass tags (TMTs) were utilized in a novel chemical footprinting approach to identify lysine residues that mediate the interaction of receptor-associated protein (RAP) with cluster II of LDL (low-density lipoprotein) receptor (LDLR)-related protein (LRP).	Lysine	92-98	LDL receptor related protein 1	Homo sapiens	256-259
25847972-4	2015	Ubiquitination of ASC at Lys(174) was critical for speck formation and inflammasome activation.	Lysine	25-28	PYD and CARD domain containing	Homo sapiens	18-21
25770209-0	2015	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3zeta via deacetylation of lysines within the 14-3-3zeta binding pocket.	Lysine	100-107	histone deacetylase 6	Homo sapiens	0-21
25770209-0	2015	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3zeta via deacetylation of lysines within the 14-3-3zeta binding pocket.	Lysine	100-107	histone deacetylase 6	Homo sapiens	23-28
25770209-4	2015	Through screening, we identified HDAC6 as the Lys(49)/Lys(120) deacetylase.	Lysine	46-49	histone deacetylase 6	Homo sapiens	33-38
25787079-2	2015	ENaC is regulated in part through signaling pathways that control the ubiquitination state of ENaC lysines.	Lysine	99-106	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	0-4
25787079-2	2015	ENaC is regulated in part through signaling pathways that control the ubiquitination state of ENaC lysines.	Lysine	99-106	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	94-98
25921090-4	2015	NAMPT mutants reveal that SIRT1 deacetylates lysine 53 (K53) and enhances eNAMPT activity and secretion.	Lysine	45-51	nicotinamide phosphoribosyltransferase	Mus musculus	0-5
25795785-0	2015	A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.	Lysine	32-38	SET domain and mariner transposase fusion gene	Homo sapiens	85-91
25795785-2	2015	SETMAR has been associated with dimethylation of histone H3 lysine 36 (H3K36) at sites of DNA damage.	Lysine	60-66	SET domain and mariner transposase fusion gene	Homo sapiens	0-6
25795785-6	2015	Our approach identified lysine 130 of the mRNA splicing factor snRNP70 as a SETMAR substrate in vitro, and we show that the enzyme primarily generates monomethylation at this position.	Lysine	24-30	SET domain and mariner transposase fusion gene	Homo sapiens	76-82
25795785-7	2015	Furthermore, we show that SETMAR methylates snRNP70 Lys-130 in cells.	Lysine	52-55	SET domain and mariner transposase fusion gene	Homo sapiens	26-32
25832546-6	2015	Additional experiments of human growth hormone melting in the presence of histidine, lysine, and sodium chloride were performed.	Lysine	85-91	growth hormone 1	Homo sapiens	32-46
25641559-0	2015	A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation.	Lysine	6-12	ataxin 1	Homo sapiens	42-50
25641559-5	2015	Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6.	Lysine	31-37	ataxin 1	Homo sapiens	106-111
25641559-5	2015	Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6.	Lysine	31-37	ubiquitin conjugating enzyme E2 E1	Homo sapiens	151-156
25641559-5	2015	Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6.	Lysine	82-88	ataxin 1	Homo sapiens	106-111
25641559-5	2015	Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6.	Lysine	82-88	ubiquitin conjugating enzyme E2 E1	Homo sapiens	151-156
25771020-2	2015	To this end, we engineered a surface consisting of heparin bound to poly-l-lysine to permit immobilization of VEGF through the C-terminal heparin-binding domain.	Lysine	68-81	vascular endothelial growth factor A	Homo sapiens	110-114
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	nuclear factor kappa B subunit 1	Homo sapiens	78-100
25739318-5	2015	Recently, an EZH2 inhibitor was reported to selectively inhibit trimethylated lysine 27 on histone H3 and to reactivate silenced genes in cancer cells.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
25477280-2	2015	Only the combined loss of EZH1 and EZH2 in mouse hepatocytes caused a depletion of global trimethylation on Lys 27 of histone H3 (H3K27me3) marks and the specific loss of over ~1900 genes at 3 mo of age.	Lysine	108-111	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	26-30
26897964-2	2015	It has been reported that EZH2 mediates transcriptional silencing of E-cadherin by trimethylating lysine 27 of histone H3 (H3K27me3).	Lysine	98-104	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	26-30
26897964-2	2015	It has been reported that EZH2 mediates transcriptional silencing of E-cadherin by trimethylating lysine 27 of histone H3 (H3K27me3).	Lysine	98-104	cadherin 1	Homo sapiens	69-79
25667225-6	2015	MR acetylation was determined by Western blot with anti-acetyl-lysine antibody after immunoprecipitation with anti-MR antibody.	Lysine	63-69	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	0-2
25915124-4	2015	SIRT6 targets acetylated histone H3 at Lys 9 and 56 (H3K9ac and H3K56ac), while TETs convert 5-methylcytosine into 5-hydroxymethylcytosine (5hmC).	Lysine	39-42	sirtuin 6	Mus musculus	0-5
25825779-8	2015	To our knowledge, this is the first structural view of APC, or any cullin-RING E3, with E2 and substrate juxtaposed, and it reveals how tripartite cullin-RING-E2 interactions establish APC"s specificity for UBCH10 and harness a flexible catalytic module to drive ubiquitination of lysines within an accessible zone.	Lysine	281-288	ubiquitin conjugating enzyme E2 C	Homo sapiens	207-213
25743599-2	2015	Indeed, over the past decade or so, it has been discovered that posttranslational modification of lysine residues plays a major role in regulating translesion DNA synthesis (TLS) and perhaps the most appreciated lysine modification is that of ubiquitination.	Lysine	98-104	FUS RNA binding protein	Homo sapiens	174-177
25743599-5	2015	In the case of human polymerase eta, ubiquitination at four lysine residues in its C-terminus appears to regulate its ability to interact with PCNA and modulate TLS.	Lysine	60-66	FUS RNA binding protein	Homo sapiens	161-164
25743599-6	2015	Within the past few years, advances in global proteomic research have revealed that many proteins involved in TLS are, in fact, subject to a previously underappreciated number of lysine modifications.	Lysine	179-185	FUS RNA binding protein	Homo sapiens	110-113
25743599-7	2015	In this review, we will summarize the known lysine modifications of several key proteins involved in TLS; PCNA and Y-family polymerases eta, iota, kappa and Rev1 and we will discuss the potential regulatory effects of such modification in controlling TLS in vivo.	Lysine	44-50	FUS RNA binding protein	Homo sapiens	101-104
25743599-7	2015	In this review, we will summarize the known lysine modifications of several key proteins involved in TLS; PCNA and Y-family polymerases eta, iota, kappa and Rev1 and we will discuss the potential regulatory effects of such modification in controlling TLS in vivo.	Lysine	44-50	REV1 DNA directed polymerase	Homo sapiens	157-161
25743599-7	2015	In this review, we will summarize the known lysine modifications of several key proteins involved in TLS; PCNA and Y-family polymerases eta, iota, kappa and Rev1 and we will discuss the potential regulatory effects of such modification in controlling TLS in vivo.	Lysine	44-50	FUS RNA binding protein	Homo sapiens	251-254
25673337-3	2015	We have identified lysine residue K95 as a key determinant of permeant anion binding in the CFTR pore.	Lysine	19-25	CF transmembrane conductance regulator	Homo sapiens	92-96
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	nuclear factor kappa B subunit 1	Homo sapiens	102-111
25800736-4	2015	We identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348 (K348).	Lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
25860502-7	2015	Meanwhile, hepatic protein contents of DNA methyltransferases 1 and adenosylhomocysteinase-like 1 were increased (P &lt; 0.05), which was associated with global genomic DNA hypermethylation (P &lt; 0.05) and diminished gene repression mark histone H3 lysine 27 trimethylation (P &lt; 0.05).	Lysine	251-257	adenosylhomocysteinase like 1	Gallus gallus	39-97
25823821-2	2015	Here we report that Shp2 is modified by SUMO1 at lysine residue 590 (K590) in its C-terminus, which is reduced by SUMO1-specific protease SENP1.	Lysine	49-55	SUMO specific peptidase 1	Homo sapiens	138-143
25884496-5	2015	We hypothesized that, in diabetes, PRC2 represses miR-200b through its histone H3 lysine-27 trimethylation mark.	Lysine	82-88	microRNA 200b	Homo sapiens	50-58
25790265-1	2015	Methylated lysine 9 on the histone 3 (H3) tail recruits heterochromatin protein 1 from Drosophila (dHP1) via its chromodomain and results in gene silencing.	Lysine	11-17	Suppressor of variegation 205	Drosophila melanogaster	56-81
25790265-1	2015	Methylated lysine 9 on the histone 3 (H3) tail recruits heterochromatin protein 1 from Drosophila (dHP1) via its chromodomain and results in gene silencing.	Lysine	11-17	Suppressor of variegation 205	Drosophila melanogaster	99-103
25825713-5	2015	In addition, we narrowed down the structural determinants to the N terminus of beta1, which contains two lysine residues (i.e., K3 and K4), which upon substitution virtually abolished the effects of beta1 on charge movement.	Lysine	105-111	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	79-84
25825713-5	2015	In addition, we narrowed down the structural determinants to the N terminus of beta1, which contains two lysine residues (i.e., K3 and K4), which upon substitution virtually abolished the effects of beta1 on charge movement.	Lysine	105-111	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	199-204
25855964-8	2015	Immunoprecipitation and peptide pull-down assays verify that PHRF1 constitutively binds to di- and trimethylated histone H3 lysine 36 (H3K36) (H3K36me2 and H3K36me3) via its PHD domain.	Lysine	124-130	PHD and ring finger domains 1	Homo sapiens	61-66
25736291-5	2015	Removal of the STIM1 lysine-rich tail prevented store-dependent cluster enlargement, whereas inhibition of cytosolic Ca(2+) elevations or removal of the STIM1L actin-binding domain had no impact on cluster expansion.	Lysine	21-27	stromal interaction molecule 1	Homo sapiens	15-20
25736291-8	2015	The ability of STIM proteins to induce cortical ER formation is dispensable for SOCE and requires the lysine-rich tail of STIM1 involved in binding to phosphoinositides.	Lysine	102-108	stromal interaction molecule 1	Homo sapiens	122-127
25629630-3	2015	A promising potential epigenetic target is the methyltransferase EZH2, which in the context of the polycomb repressive complex 2 (PRC2) is well known to tri-methylate histone H3 at lysine 27 (H3K27me3) and elicit gene silencing.	Lysine	181-187	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
25745086-3	2015	Previously, we reported selective uptake of (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T::hB1R tumor xenografts in mice.	Lysine	77-80	bradykinin receptor, beta 1	Mus musculus	117-121
25853889-3	2015	We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFkappaBp50, mutation of which abrogated the interaction of NFkappaBp50 with the SLR polyU and impaired NFkappaBp50 mediated MYB elongation.	Lysine	26-32	nuclear factor kappa B subunit 1	Homo sapiens	84-95
25853889-3	2015	We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFkappaBp50, mutation of which abrogated the interaction of NFkappaBp50 with the SLR polyU and impaired NFkappaBp50 mediated MYB elongation.	Lysine	26-32	nuclear factor kappa B subunit 1	Homo sapiens	144-155
25853889-3	2015	We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFkappaBp50, mutation of which abrogated the interaction of NFkappaBp50 with the SLR polyU and impaired NFkappaBp50 mediated MYB elongation.	Lysine	26-32	nuclear factor kappa B subunit 1	Homo sapiens	144-155
25853889-4	2015	We observed that the TAR RNA-binding region of Tat is homologous to the NFkappaBp50 RHD lysine-rich motif, a finding consistent with HIV Tat acting as an effector of MYB transcriptional elongation in an SLR dependent manner.	Lysine	88-94	nuclear factor kappa B subunit 1	Homo sapiens	72-83
25697176-4	2015	Rather, our genetic analyses suggest that in the presence of replicative stress H3 lysine 56 acetylation uncouples the Cdc45-Mcm2-7-GINS DNA helicase complex and DNA polymerases through the replisome component Ctf4.	Lysine	83-89	DNA replication initiation factor CDC45	Saccharomyces cerevisiae S288C	119-124
25672970-5	2015	We demonstrated that C-30-27 selectively inhibited acetylation-dependent nuclear factor-kappaB (NF-kappaB) at Lys-122 and suppressed the NF-kappaB-mediated inflammatory response induced by lipopolysaccharide (LPS) or Abeta in both BV2 and Neuro-2A (N2A) cells.	Lysine	110-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-94
25672970-5	2015	We demonstrated that C-30-27 selectively inhibited acetylation-dependent nuclear factor-kappaB (NF-kappaB) at Lys-122 and suppressed the NF-kappaB-mediated inflammatory response induced by lipopolysaccharide (LPS) or Abeta in both BV2 and Neuro-2A (N2A) cells.	Lysine	110-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
25745086-3	2015	Previously, we reported selective uptake of (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T::hB1R tumor xenografts in mice.	Lysine	77-80	bradykinin receptor, beta 1	Mus musculus	117-120
25925379-0	2015	Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.	Lysine	47-53	AKT serine/threonine kinase 1	Homo sapiens	17-20
25537453-3	2015	To elucidate the role of methylation of histone H3 at lysine 4 (H3K4) mediated by menin-HMT complexes during PanNET formation, genome-wide histone H3 lysine 4 trimethylation (H3K4me3) signals were mapped in pancreatic islets using unbiased chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq).	Lysine	54-60	menin 1	Homo sapiens	82-87
25516403-2	2015	Introduction of a single lysine residue into the nonenzymatic protein calmodulin led to a 15,000-fold increase in the second order rate constant for retroaldol reaction with methodol as a substrate.	Lysine	25-31	calmodulin 1	Homo sapiens	70-80
25577037-1	2015	INTRODUCTION: The aim of this study was to examine whether the substitution of the Lys linker with the aminooctanoic acid (Aoc) and polyethylene glycol (PEG) linker could substantially decrease the non-specific renal uptake of (99m)Tc-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Lysine	83-86	proopiomelanocortin	Homo sapiens	266-302
25577037-1	2015	INTRODUCTION: The aim of this study was to examine whether the substitution of the Lys linker with the aminooctanoic acid (Aoc) and polyethylene glycol (PEG) linker could substantially decrease the non-specific renal uptake of (99m)Tc-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Lysine	83-86	proopiomelanocortin	Homo sapiens	304-313
25788266-4	2015	Here, we investigated the association between genome-wide occupancy of histone H4 acetylation at lysine 12 (H4K12ac) and BRD4 in the context of estrogen-induced transcription.	Lysine	97-103	bromodomain containing 4	Homo sapiens	121-125
25749385-5	2015	We found that G9a, a histone methyltransferase, interacts with Snail and mediates Snail-induced transcriptional repression of E-cadherin and EMT, through methylation of histone H3 lysine-9 (H3K9).	Lysine	180-186	snail family transcriptional repressor 1	Homo sapiens	82-87
25594381-0	2015	Protein lysine acetylation by p300/CBP.	Lysine	8-14	CREB binding protein	Homo sapiens	35-38
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Lysine	68-74	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	122-127
25734520-1	2015	Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities.	Lysine	60-66	histone deacetylase 6	Homo sapiens	0-21
25734520-1	2015	Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities.	Lysine	60-66	histone deacetylase 6	Homo sapiens	23-28
29124137-6	2015	Moreover, with Ki 5.3x105 muM, the "site2" also illustrates selectivity, by discriminating the stereochemical mutant peptide (YSFkPMPLaR; k=D-Lys), known to be inert toward C5aR, up to 1 mM concentration.	Lysine	142-145	complement C5a receptor 1	Homo sapiens	173-177
25852572-9	2015	Finally, the acetylation status of SIRT3 target lysine residues on MnSOD (K122) or oligomycin-sensitivity conferring protein (OSCP; K139) was not altered in either mouse or human skeletal muscle in response to acute exercise.	Lysine	48-54	superoxide dismutase 2, mitochondrial	Mus musculus	67-72
25797242-8	2015	Moreover, the aforementioned positive effects were abolished by blocking PI3K/Akt/eNOS pathway with LY-294002.	Lysine	100-102	AKT serine/threonine kinase 1	Homo sapiens	78-81
25797242-8	2015	Moreover, the aforementioned positive effects were abolished by blocking PI3K/Akt/eNOS pathway with LY-294002.	Lysine	100-102	nitric oxide synthase 3	Homo sapiens	82-86
25762331-2	2015	This article demonstrates that aspirin (the quintessential acylating pharmacon) can inhibit the amyloidogenesis of superoxide dismutase (SOD1) by increasing the intrinsic net negative charge of the polypeptide, i.e., by acetylation (neutralization) of multiple lysines.	Lysine	261-268	superoxide dismutase 1	Homo sapiens	137-141
25687760-9	2015	Finally, Ezh1 was found to suppress the transcription of Tollip by directly targeting the proximal promoter of tollip and maintaining the high level of trimethylation of histone H3 lysine 27 there.	Lysine	181-187	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	9-13
25687760-9	2015	Finally, Ezh1 was found to suppress the transcription of Tollip by directly targeting the proximal promoter of tollip and maintaining the high level of trimethylation of histone H3 lysine 27 there.	Lysine	181-187	toll interacting protein	Mus musculus	57-63
25758227-7	2015	Our results also demonstrate that loss of Hdac1 and Hdac2 in the UB epithelium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383; these post-translational modifications are known to boost p53 stability and transcriptional activity.	Lysine	151-157	histone deacetylase 2	Mus musculus	52-57
25793886-7	2015	This model exhibits an equilibrium state through molecular dynamics simulation and is consistent with most of the experimental results known from CCL/MS on lysine pairs, fluorescence resonance energy transfer and hydrogen exchange.	Lysine	156-162	crystallin gamma E, pseudogene	Homo sapiens	146-149
25489924-6	2015	However, UCH-L3 could also cleave chemically synthesized isopeptide-linked Ub from lysine 11 (K11) of SUMO2 with similar efficiency, demonstrating that UCH DUB activity is not limited to peptide-linked Ub.	Lysine	83-89	ubiquitin C-terminal hydrolase L3	Homo sapiens	9-15
25762331-5	2015	Lysines in wild-type- and ALS-variant apo-SOD1 could also be peracetylated with aspirin after fibrillization, resulting in supercharged fibrils, with increases in formal net charge of ~2 million units.	Lysine	0-7	superoxide dismutase 1	Homo sapiens	42-46
25614281-5	2015	We focused on miR-101 and 1 of its targets, enhancer of zester homolog-2 (EZH2), which trimethylates the lysine 27 of histone 3, thus repressing gene transcription.	Lysine	105-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	44-72
25727006-2	2015	We have discovered that CUL4A-RBX1-COPS8 E3 ligase activity is required for CENP-A ubiquitylation on lysine 124 (K124) and CENP-A centromere localization.	Lysine	101-107	cullin 4A	Homo sapiens	24-29
25614281-5	2015	We focused on miR-101 and 1 of its targets, enhancer of zester homolog-2 (EZH2), which trimethylates the lysine 27 of histone 3, thus repressing gene transcription.	Lysine	105-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	74-78
25569264-6	2015	We demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 at lysine 9 tri-methylation at this promoter is dependent on Setdb1 expression.	Lysine	119-125	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	22-27
29163876-4	2015	The arms of the best inhibitors also contained a tailor-made GCP oxoanion binding motif attached to a lysine side chain.	Lysine	102-108	golgin B1	Homo sapiens	61-64
25569264-6	2015	We demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 at lysine 9 tri-methylation at this promoter is dependent on Setdb1 expression.	Lysine	119-125	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	177-183
25499082-3	2015	Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98.	Lysine	182-185	OTU deubiquitinase 5	Homo sapiens	20-40
25681283-6	2015	A further prolonged analog, f-Nle-Leu-Phe-Nle-Tyr-Lys-(Asn-Gly)5-myc, designed to decrease the possible steric hindrance between FPR1 and the bound anti-myc antibody, has little affinity for the receptor, precluding a direct assessment of this issue.	Lysine	50-53	formyl peptide receptor 1	Homo sapiens	129-133
26020882-8	2015	Increasing the SID Trp to Lys ratio increased the level of serum GH (quadratic effect, &lt; 0.05) and also increased the level of serum IGF-1 (linear and quadratic effect, &lt; 0.05).	Lysine	26-29	IGF1	Sus scrofa	136-141
25614014-4	2015	The present review discusses how the glycation sites of lysine residues in HSA are modified with glucose, whereas the glycation sites of lysine residues are located inside of HSA as well as the direct comparison of glycation rates between GA and HbA1c using human blood.	Lysine	56-62	albumin	Homo sapiens	75-78
25614014-4	2015	The present review discusses how the glycation sites of lysine residues in HSA are modified with glucose, whereas the glycation sites of lysine residues are located inside of HSA as well as the direct comparison of glycation rates between GA and HbA1c using human blood.	Lysine	137-143	albumin	Homo sapiens	175-178
25779927-9	2015	DNA sequencing of the KCNQ1 gene identified a heterozygous single base pair mutation, unique to these 3 dogs, which changes a conserved amino acid from threonine to lysine and is predicted to change protein structure.	Lysine	165-171	potassium voltage-gated channel subfamily Q member 1	Canis lupus familiaris	22-27
25574816-7	2015	RESULTS: Histone H1.2, which lacks histidine, was phosphorylated by phosphoramidate on several lysine residues, as shown by MS. PHPT1 was shown to dephosphorylate phosphohistone H1 at a rate similar to that previously described for the dephosphorylation of phosphohistidine-containing peptides.	Lysine	95-101	phosphohistidine phosphatase 1	Homo sapiens	128-133
25578968-1	2015	The histone demethylase JMJ14 catalyzes histone demethylation at lysine 4 of histone 3 and is involved in transcriptional repression and flowering time control in Arabidopsis.	Lysine	65-71	JUMONJI 14	Arabidopsis thaliana	24-29
25901190-1	2015	EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target genes via local chromatin reorganization.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25654763-3	2015	Lys 109 within Fbxl7 is an essential acceptor site for ubiquitin conjugation by Fbxl18.	Lysine	0-3	F-box and leucine rich repeat protein 7	Homo sapiens	15-20
25654763-5	2015	Ectopically expressed Fbxl7 induces apoptosis in Hela cells, an effect profoundly accentuated after cellular depletion of Fbxl18 protein or expression of Fbxl7 plasmids encoding mutations at either Lys 109 or within the FQ motif.	Lysine	198-201	F-box and leucine rich repeat protein 7	Homo sapiens	22-27
25656485-4	2015	Mechanistically, WDR5 regulated various functions in bladder cancer by mediating the transcription of cyclin B1, cyclin E1, cyclin E2, UHMK1, MCL1, BIRC3 and Nanog by histone H3 lysine 4 trimethylation.	Lysine	178-184	WD repeat domain 5	Homo sapiens	17-21
25419905-0	2015	Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.	Lysine	17-23	insulin	Homo sapiens	95-102
25419905-9	2015	CONCLUSIONS: Circulating concentrations of lysine, tyrosine, and valine were independently and positively associated with GDM through modifying insulin resistance and secretion.	Lysine	43-49	insulin	Homo sapiens	144-151
25512382-9	2015	The major complex structure shows a salt bridge formation between Glu-213/Glu-214 of FBD and Lys-87 of cyt c, which may be essential for the formation of the complex, and a predicted electron transfer pathway mediated by Lys-13 of cyt c. The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.	Lysine	93-96	cytochrome p450 oxidoreductase	Homo sapiens	289-292
25512382-9	2015	The major complex structure shows a salt bridge formation between Glu-213/Glu-214 of FBD and Lys-87 of cyt c, which may be essential for the formation of the complex, and a predicted electron transfer pathway mediated by Lys-13 of cyt c. The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.	Lysine	93-96	cytochrome p450 oxidoreductase	Homo sapiens	297-300
25512382-9	2015	The major complex structure shows a salt bridge formation between Glu-213/Glu-214 of FBD and Lys-87 of cyt c, which may be essential for the formation of the complex, and a predicted electron transfer pathway mediated by Lys-13 of cyt c. The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.	Lysine	221-224	cytochrome p450 oxidoreductase	Homo sapiens	289-292
25512382-9	2015	The major complex structure shows a salt bridge formation between Glu-213/Glu-214 of FBD and Lys-87 of cyt c, which may be essential for the formation of the complex, and a predicted electron transfer pathway mediated by Lys-13 of cyt c. The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.	Lysine	221-224	cytochrome p450 oxidoreductase	Homo sapiens	297-300
25515659-1	2015	PR-SET7-mediated histone 4 lysine 20 methylation has been implicated in mitotic condensation, DNA damage response and replication licensing.	Lysine	27-33	lysine methyltransferase 5A	Mus musculus	0-7
25423611-7	2015	The same strategy revealed 21 CML sites in 17 different proteins, including modified lysine residues 88 and 396 of human serum albumin, in a pooled plasma sample that was obtained from patients with type 2 diabetes mellitus.	Lysine	85-91	albumin	Homo sapiens	121-134
25451919-4	2015	Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, leading us to propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination.	Lysine	53-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	265-271
25499082-3	2015	Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98.	Lysine	182-185	OTU deubiquitinase 5	Homo sapiens	42-47
25499082-3	2015	Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98.	Lysine	182-185	programmed cell death 5	Homo sapiens	62-67
25499082-3	2015	Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98.	Lysine	182-185	programmed cell death 5	Homo sapiens	134-139
25499082-3	2015	Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to PDCD5 in response to etoposide treatment and increased the stability of PDCD5 by mediating deubiquitination of PDCD5 at Lys-97/98.	Lysine	182-185	programmed cell death 5	Homo sapiens	134-139
25523083-4	2015	The autoproteolytic cleavage of Anabaena LexA occurs at pH 8.5 and above, stimulated by the addition of Ca(2+) and in the temperature range of 30-57 C. Mutational analysis of Anabaena LexA protein indicated that the cleavage occurred at the peptide bond between Ala-84 and Gly-85, and optimal cleavage required the presence of Ser-118 and Lys-159, as also observed for LexA protein of Escherichia coli.	Lysine	339-342	DNA repair system	Escherichia coli	41-45
25533199-3	2015	Histone H2B ubiquitination at lysine 120 (H2Bub1) is regulated by RNF20, an E3 ubiquitin ligase that is altered in many tumor types.	Lysine	30-36	ring finger protein 20	Homo sapiens	66-71
25523083-4	2015	The autoproteolytic cleavage of Anabaena LexA occurs at pH 8.5 and above, stimulated by the addition of Ca(2+) and in the temperature range of 30-57 C. Mutational analysis of Anabaena LexA protein indicated that the cleavage occurred at the peptide bond between Ala-84 and Gly-85, and optimal cleavage required the presence of Ser-118 and Lys-159, as also observed for LexA protein of Escherichia coli.	Lysine	339-342	DNA repair system	Escherichia coli	184-188
25523083-4	2015	The autoproteolytic cleavage of Anabaena LexA occurs at pH 8.5 and above, stimulated by the addition of Ca(2+) and in the temperature range of 30-57 C. Mutational analysis of Anabaena LexA protein indicated that the cleavage occurred at the peptide bond between Ala-84 and Gly-85, and optimal cleavage required the presence of Ser-118 and Lys-159, as also observed for LexA protein of Escherichia coli.	Lysine	339-342	DNA repair system	Escherichia coli	184-188
25425640-2	2015	Bovine beta-arrestin 2 has been shown to be SUMOylated on the lysine 400 residue, which links it to the endocytosis of the beta2-adrenergic receptor.	Lysine	62-68	LOC100851153	Bos taurus	7-22
25565142-2	2015	We show that menin activates the long noncoding RNA maternally expressed gene 3 (Meg3) by histone-H3 lysine-4 trimethylation and CpG hypomethylation at the Meg3 promoter CRE site, to allow binding of the transcription factor cAMP response element-binding protein.	Lysine	101-107	multiple endocrine neoplasia 1	Mus musculus	13-18
25409661-1	2015	EZH2 inhibition can decrease global histone H3 lysine 27 trimethylation (H3K27me3) and thereby reactivates silenced tumor suppressor genes.	Lysine	47-53	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25505069-8	2015	SQSTM1 was phosphorylated on serine-351 and -403, while Keap1 was polyubiquitinated with lysine-63-ubiquitin chains, modifications known to increase their mutual affinity and interaction, leading to Keap1 degradation and Nrf2 activation.	Lysine	89-95	kelch like ECH associated protein 1	Homo sapiens	56-61
25473116-6	2015	Further, mutating a single conserved lysine residue potently disrupted WAVE1"s inhibitory effects.	Lysine	37-43	WASP family member 1	Homo sapiens	71-76
25531389-5	2015	The multiple locations are attributed to snorkeling of lysine side chains for KALP and to the distribution of antiparallel beta-sheet registries for HFP.	Lysine	55-61	anosmin 2, pseudogene	Homo sapiens	78-82
25505183-6	2015	The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when docked in AS PKCdelta, and this interaction prevented the potential interaction of ATP with Lys-378, Glu-428, Leu-430, and Phe-633 residues.	Lysine	170-173	inorganic pyrophosphatase 1	Homo sapiens	25-28
25505183-6	2015	The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when docked in AS PKCdelta, and this interaction prevented the potential interaction of ATP with Lys-378, Glu-428, Leu-430, and Phe-633 residues.	Lysine	170-173	inorganic pyrophosphatase 1	Homo sapiens	37-40
25425640-3	2015	Here we identify a major SUMOylation site, lysine 295, on human beta-arrestin 2.	Lysine	43-49	arrestin beta 2	Homo sapiens	64-79
25416785-4	2015	DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum albumin, glyceraldehyde-3-phosphate dehydrogenase, aldolase, and aspartate aminotransferase and thus reactivates these proteins.	Lysine	42-49	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	107-147
25611389-11	2015	Pharmacological inhibition of EZH2 led to significant reduction in trimethylated histone H3 on lysine 27 (H3K27) methylation, marked reduction in cell proliferation, and migration in vitro.	Lysine	95-101	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
25575817-2	2015	In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP.	Lysine	44-50	retinol binding protein 2	Homo sapiens	72-76
25361163-1	2015	The histone methyltransferase DOT1L, solely responsible for histone H3 lysine 79 (H3K79) methylation, is associated with gene activation.	Lysine	71-77	DOT1 like histone lysine methyltransferase	Homo sapiens	30-35
25492870-4	2015	Efficient degradation of lysine-free Asi2 requires E3-ligase Doa10 and E2 enzymes Ubc6 and Ubc7, components of the endoplasmic reticulum-associated degradation pathway.	Lysine	25-31	E2 ubiquitin-conjugating protein UBC6	Saccharomyces cerevisiae S288C	82-86
25492870-4	2015	Efficient degradation of lysine-free Asi2 requires E3-ligase Doa10 and E2 enzymes Ubc6 and Ubc7, components of the endoplasmic reticulum-associated degradation pathway.	Lysine	25-31	E2 ubiquitin-conjugating protein UBC7	Saccharomyces cerevisiae S288C	91-95
25395428-1	2015	Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27).	Lysine	132-138	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	47-51
25555129-6	2015	Lysine clusters are predicted to be high-affinity substrates of mitochondrial deacetylase SIRT3 both in vitro and in vivo.	Lysine	0-6	sirtuin 3	Homo sapiens	90-95
25603177-1	2015	Post-translational modifications have been identified to be of great importance in cancers and lysine acetylation, which can attract the multifunctional transcription factor BRD4, has been identified as a potential therapeutic target.	Lysine	95-101	bromodomain containing 4	Homo sapiens	174-178
25941994-2	2015	Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromatin.	Lysine	94-100	bromodomain containing 4	Homo sapiens	0-21
25987043-1	2015	BACKGROUND: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression.	Lysine	98-104	DOT1 like histone lysine methyltransferase	Homo sapiens	49-54
25457983-3	2015	In the present study, Poly I:C (PIC, a TLR3 agonist), STAT3 siRNA and OVA antigen were co-encapsulated by poly (ethylene glycol)-b-poly (L-lysine)-b-poly (L-leucine) (PEG-PLL-PLLeu) polypeptide micelles to generate PMP/OVA/siRNA nanovaccine, which was aimed to effectively overcome DC dysfunction in vivo by deleting STAT3 gene in situ.	Lysine	136-146	signal transducer and activator of transcription 3	Homo sapiens	54-59
25394993-2	2015	We previously reported two strategies for stabilizing FN against proteolytic degradation; the first conjugated polyethylene glycol (PEG) through cysteine residues and the second conjugated PEG chains of varying molecular weight on lysine residues.	Lysine	231-237	fibronectin 1	Homo sapiens	54-56
25394993-3	2015	PEGylation of FN via lysine residues resulted in increased resistance to proteolysis with increasing PEG size, but an overall decrease in biological activity, as characterized by cell and gelatin binding.	Lysine	21-27	fibronectin 1	Homo sapiens	14-16
25394993-4	2015	Our latest method to stabilize FN against proteolysis masks functional regions in the protein during lysine PEGylation.	Lysine	101-107	fibronectin 1	Homo sapiens	31-33
25854924-1	2015	Enhancer of Zeste Homolog 2 (EZH2) is the core component of the polycomb repressive complex 2 (PRC2), possessing the enzymatic activity in generating di/tri-methylated lysine 27 in histone H3.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
25854924-1	2015	Enhancer of Zeste Homolog 2 (EZH2) is the core component of the polycomb repressive complex 2 (PRC2), possessing the enzymatic activity in generating di/tri-methylated lysine 27 in histone H3.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
25535382-6	2015	Among the altered loci of Y chromosome-linked genes, KDM5D, which encodes Lys (K)-specific demethylase 5D, showed increased methylation at several CpG sites in both normal and HD cells, as well as in DNA isolated from sperm from drug-treated male mice.	Lysine	74-77	lysine (K)-specific demethylase 5D	Mus musculus	53-58
25556531-3	2015	Here, we identify lysine acetylation as a novel post-translational modification controlling TDP-43 function and aggregation.	Lysine	18-24	TAR DNA binding protein	Homo sapiens	92-98
25559185-7	2015	In addition, targeted recruitment of YY1 proteins facilitated ectopic LAD formation dependent on histone H3 lysine 27 trimethylation and histone H3 lysine di- and trimethylation.	Lysine	108-114	YY1 transcription factor	Homo sapiens	37-40
25559185-7	2015	In addition, targeted recruitment of YY1 proteins facilitated ectopic LAD formation dependent on histone H3 lysine 27 trimethylation and histone H3 lysine di- and trimethylation.	Lysine	148-154	YY1 transcription factor	Homo sapiens	37-40
25077680-2	2015	Enhancer of zeste homology 2 (EZH2), participating in gene expression silencing by trimethylating histone 3 lysine 27 (H3K27me3), is often up-regulated in EOC.	Lysine	108-114	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-28
25077680-2	2015	Enhancer of zeste homology 2 (EZH2), participating in gene expression silencing by trimethylating histone 3 lysine 27 (H3K27me3), is often up-regulated in EOC.	Lysine	108-114	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
25941994-2	2015	Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromatin.	Lysine	94-100	bromodomain containing 4	Homo sapiens	23-27
26095945-5	2015	The sulfoxide derivative of both Tbeta4 and Tbeta10 and the acetylated derivatives at lysine residues of Tbeta4 were also characterized.	Lysine	86-92	thymosin beta 4 X-linked	Homo sapiens	105-111
26004134-4	2015	PRC2 contains the EZH2 subunit, which catalyzes the trimethylation of histone 3 lysine 27, a gene silencing marker.	Lysine	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	18-22
26011738-1	2015	We synthesized polymeric gene carriers consisting of poly-L-lysine (PLL) main chain modified both with substrate peptide for protein kinase Calpha (PKCalpha) and alkanethiol (pentadecanethiol).	Lysine	53-66	protein kinase C alpha	Homo sapiens	125-146
25564072-3	2015	This is a self-regulated event as the very presence of fibrin initiates plasminogen activation on the fibrin surface due to the presentation of exposed C-terminal lysine residues in fibrin that allow plasminogen to position itself via its lysine binding sites and to be more efficiently cleaved by tissue-type plasminogen activator (t-PA).	Lysine	163-169	plasminogen activator, tissue type	Homo sapiens	298-331
25564072-3	2015	This is a self-regulated event as the very presence of fibrin initiates plasminogen activation on the fibrin surface due to the presentation of exposed C-terminal lysine residues in fibrin that allow plasminogen to position itself via its lysine binding sites and to be more efficiently cleaved by tissue-type plasminogen activator (t-PA).	Lysine	163-169	plasminogen activator, tissue type	Homo sapiens	333-337
25755737-9	2015	Vaspin increased total Akt and Ser(473)-phospho-Akt expression and these effects can be blocked by LY-2940002.	Lysine	99-101	serpin family A member 12	Homo sapiens	0-6
25755737-9	2015	Vaspin increased total Akt and Ser(473)-phospho-Akt expression and these effects can be blocked by LY-2940002.	Lysine	99-101	AKT serine/threonine kinase 1	Homo sapiens	48-51
26011738-1	2015	We synthesized polymeric gene carriers consisting of poly-L-lysine (PLL) main chain modified both with substrate peptide for protein kinase Calpha (PKCalpha) and alkanethiol (pentadecanethiol).	Lysine	53-66	protein kinase C alpha	Homo sapiens	148-156
25614305-11	2015	Persistently low plasmatic levels of lysine, arginine, and ornithine, associated with dietary protein and caloric restriction and systemic inflammation, could determine a defect in coupling GH to IGF-1 production explaining why GH replacement therapy is not able to significantly improve growth impairment.	Lysine	37-43	insulin like growth factor 1	Homo sapiens	196-201
26598853-5	2015	Individual amino acids such as lysine and arginine have been found to be factors linked to growth hormone release in young children via the somatotropic axis and high intakes are inversely associated with fat mass index in pre-pubertal lean girls.	Lysine	31-37	growth hormone 1	Homo sapiens	91-105
25308486-5	2015	It also serves as a substrate for deacylases SIRT3, SIRT4, and SIRT5, which modify protein posttranslational modifications on lysine within the mitochondrial compartment.	Lysine	126-132	sirtuin 4	Homo sapiens	52-57
26179046-3	2015	Both Gli1 and Gli2 are acetylated at a conserved lysine, and this modification causes the inhibition of their transcriptional activity.	Lysine	49-55	GLI family zinc finger 2	Homo sapiens	14-18
25736759-2	2015	In response to signal activation and transmission, ubiquitin E1, E2, and E3 enzymes are employed to generate a lysine 48-linked ubiquitin chain that triggers degradation of IkappaBalpha by the proteasome.	Lysine	111-117	NFKB inhibitor alpha	Homo sapiens	173-185
25815376-1	2015	SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues.	Lysine	100-106	tumor protein p53	Homo sapiens	16-19
25736763-2	2015	Within the seven NF-kappaB family proteins, the RelA subunit of NF-kappaB is the most studied for its regulation by lysine acetylation and methylation.	Lysine	116-122	nuclear factor kappa B subunit 1	Homo sapiens	17-26
25736763-2	2015	Within the seven NF-kappaB family proteins, the RelA subunit of NF-kappaB is the most studied for its regulation by lysine acetylation and methylation.	Lysine	116-122	nuclear factor kappa B subunit 1	Homo sapiens	64-73
25736763-3	2015	Acetylation or methylation at different lysine residues modulates distinct functions of NF-kappaB, including DNA-binding and transcription activity, protein stability, and its interaction with NF-kappaB modulators.	Lysine	40-46	nuclear factor kappa B subunit 1	Homo sapiens	88-97
25736763-3	2015	Acetylation or methylation at different lysine residues modulates distinct functions of NF-kappaB, including DNA-binding and transcription activity, protein stability, and its interaction with NF-kappaB modulators.	Lysine	40-46	nuclear factor kappa B subunit 1	Homo sapiens	193-202
26006083-7	2015	The treated ABCB1 had reduced mobility on SDS-PAGE, and mass spectrometry identified eight lysine residues, K271, K272, K575, K685, K877, K885, K887 and K1062 that were ubiquitinated by NEDD4-1.	Lysine	91-97	ATP binding cassette subfamily B member 1	Homo sapiens	12-17
26112741-2	2015	SPAK and OSR1 are both regulated by WNK (with-no-K(Lys)) kinases.	Lysine	51-54	odd-skipped related transcription factor 1	Mus musculus	9-13
25311840-3	2015	In an attempt to explore the substrate diversity of HDAC6, we performed quantitative proteomic analyses to monitor changes in the abundance of protein lysine acetylation in response to HDAC6 deficiency.	Lysine	151-157	histone deacetylase 6	Mus musculus	52-57
25488809-4	2015	We have identified the histone H3 lysine 9 mono- and di-methyl demethylase enzyme KDM3A as a positive regulator of ER activity.	Lysine	34-40	estrogen receptor 1	Homo sapiens	115-117
24912396-2	2015	EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), responsible for tri-methylation of lysine 27 on histone 3 (H3K27me3) that leads to gene silencing.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	223-229	AGAMOUS-like 20	Arabidopsis thaliana	162-177
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	223-229	AGAMOUS-like 20	Arabidopsis thaliana	179-183
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	223-229	AGAMOUS-like 20	Arabidopsis thaliana	184-189
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	272-278	AGAMOUS-like 20	Arabidopsis thaliana	162-177
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	272-278	AGAMOUS-like 20	Arabidopsis thaliana	179-183
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	272-278	AGAMOUS-like 20	Arabidopsis thaliana	184-189
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Lysine	74-77	proopiomelanocortin	Homo sapiens	3-12
25035152-8	2015	Post-translational histone methylation at different histone 3 lysine residues was also observed to control the expression of genes related to AH as lysine-specific demethylase-1(LSD1), HSD11B2, and epithelial sodium channel subunit alpha (SCNN1A).	Lysine	62-68	sodium channel epithelial 1 subunit alpha	Homo sapiens	239-245
28670509-6	2015	Mechanistically, hydrogen peroxide is produced as a byproduct of LOXL2 when using an appropriate substrate, lysine.	Lysine	108-114	lysyl oxidase like 2	Homo sapiens	65-70
25500711-1	2015	Tissue transglutaminase (TG2) catalyzes the cross-linking of proteins by the formation of isopeptide bonds between glutamine (Gln) and lysine (Lys) side chains.	Lysine	135-141	transglutaminase 2	Homo sapiens	0-23
26021170-4	2015	NaBu activated the TP53 protein via hyper acetylation at lysine residue K382, without significant changes in the level of protein expression.	Lysine	57-63	tumor protein p53	Homo sapiens	19-23
25500711-1	2015	Tissue transglutaminase (TG2) catalyzes the cross-linking of proteins by the formation of isopeptide bonds between glutamine (Gln) and lysine (Lys) side chains.	Lysine	143-146	transglutaminase 2	Homo sapiens	0-23
25543846-1	2014	BACKGROUND: Trypsinogen is the inactive precursor of trypsin, a serine protease that cleaves proteins and peptides after arginine and lysine residues.	Lysine	134-140	trypsinogen	Cavia porcellus	12-23
25494638-0	2014	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	Lysine	17-23	nuclear receptor binding SET domain protein 2	Homo sapiens	45-49
25521755-7	2014	Rg3 also decreased the expression of HDAC3 and increased the acetylation of p53 on lysine (k373/k382).	Lysine	83-89	tumor protein p53	Homo sapiens	76-79
25183519-3	2014	Here, we show that SETDB1, a histone H3-lysine 9 (H3K9)-specific methyltransferase, cooperates with Argonaute-2 (AGO2) and plays an essential role in agRNA-induced TGS.	Lysine	40-46	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	19-25
25183519-3	2014	Here, we show that SETDB1, a histone H3-lysine 9 (H3K9)-specific methyltransferase, cooperates with Argonaute-2 (AGO2) and plays an essential role in agRNA-induced TGS.	Lysine	40-46	argonaute RISC catalytic component 2	Homo sapiens	100-111
25055869-4	2014	Here, we show that the level of trimethylation of histone H3 on lysine 27, a hallmark of the activity of EZH2, a component of repressive Polycomb Group (PcG) complexes like PRC2, is increased on reactivation of the silenced allele by either the DNA demethylating agent 5-azadeoxycytidine or the SIRT1 inhibitor splitomicin.	Lysine	64-70	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	105-109
25385088-6	2014	By monitoring surface accessibility of XPA lysines to NHS-biotin modification in the free protein and the DNA junction-bound complex we show that XPA physically interacts with the DNA junctions via two lysines, K168 and K179, located in the previously known XPA(98-219) DBD (DNA-binding domain).	Lysine	202-209	XPA, DNA damage recognition and repair factor	Homo sapiens	146-149
25381251-4	2014	The mutant ETBR (designated "5KR mutant") in which 5 lysine residues in the C-tail were substituted to arginine was not ubiquitinated, and its rates of internalization and degradation after ET-1 stimulation became slower, being comparable with those of ETAR.	Lysine	53-59	endothelin receptor type B	Homo sapiens	11-15
25381251-7	2014	A series of ETBR mutants (designated "4KR mutant"), in which either one of 5 arginine residues of the 5KR mutant was reverted to lysine, were normally ubiquitinated, internalized, and degraded, with ERK phosphorylation being normalized.	Lysine	129-135	endothelin receptor type B	Homo sapiens	12-16
25381251-8	2014	These results demonstrate that agonist-induced ubiquitination at either lysine residue in the C-tail of ETBR but not ETAR switches intracellular trafficking from recycling to plasma membrane to targeting to lysosome, causing decreases in the cell surface level of ETBR and intracellular signaling.	Lysine	72-78	endothelin receptor type B	Homo sapiens	104-108
25381251-8	2014	These results demonstrate that agonist-induced ubiquitination at either lysine residue in the C-tail of ETBR but not ETAR switches intracellular trafficking from recycling to plasma membrane to targeting to lysosome, causing decreases in the cell surface level of ETBR and intracellular signaling.	Lysine	72-78	endothelin receptor type B	Homo sapiens	264-268
25512562-2	2014	Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo.	Lysine	73-76	enoki mushroom	Drosophila melanogaster	41-45
25512562-2	2014	Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo.	Lysine	73-76	enoki mushroom	Drosophila melanogaster	46-50
25385088-6	2014	By monitoring surface accessibility of XPA lysines to NHS-biotin modification in the free protein and the DNA junction-bound complex we show that XPA physically interacts with the DNA junctions via two lysines, K168 and K179, located in the previously known XPA(98-219) DBD (DNA-binding domain).	Lysine	43-50	XPA, DNA damage recognition and repair factor	Homo sapiens	39-42
25385088-6	2014	By monitoring surface accessibility of XPA lysines to NHS-biotin modification in the free protein and the DNA junction-bound complex we show that XPA physically interacts with the DNA junctions via two lysines, K168 and K179, located in the previously known XPA(98-219) DBD (DNA-binding domain).	Lysine	43-50	XPA, DNA damage recognition and repair factor	Homo sapiens	146-149
25385088-6	2014	By monitoring surface accessibility of XPA lysines to NHS-biotin modification in the free protein and the DNA junction-bound complex we show that XPA physically interacts with the DNA junctions via two lysines, K168 and K179, located in the previously known XPA(98-219) DBD (DNA-binding domain).	Lysine	43-50	XPA, DNA damage recognition and repair factor	Homo sapiens	146-149
25385088-6	2014	By monitoring surface accessibility of XPA lysines to NHS-biotin modification in the free protein and the DNA junction-bound complex we show that XPA physically interacts with the DNA junctions via two lysines, K168 and K179, located in the previously known XPA(98-219) DBD (DNA-binding domain).	Lysine	202-209	XPA, DNA damage recognition and repair factor	Homo sapiens	146-149
25494638-0	2014	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	Lysine	17-23	nuclear receptor binding SET domain protein 2	Homo sapiens	50-55
25494638-0	2014	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	Lysine	17-23	nuclear receptor binding SET domain protein 2	Homo sapiens	56-61
25494638-8	2014	CONCLUSIONS: Our data highlight the versatility of NSD1, NSD2, and NSD3 for recognizing and methylating several histone lysine marks on histones H3 and H4.	Lysine	120-126	nuclear receptor binding SET domain protein 2	Homo sapiens	57-61
25486523-5	2014	Sulforaphane stimulates ubiquitination and acetylation of SUV39H1 within a C-terminal nuclear localization signal peptide motif and coincides with its dissociation from chromatin and a decrease in global trimethyl-histone H3 lysine 9 (H3K9me3) levels.	Lysine	225-231	SUV39H1 histone lysine methyltransferase	Homo sapiens	58-65
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Lysine	44-50	vascular cell adhesion molecule 1	Homo sapiens	176-209
25685357-8	2014	The other peptide (Valine-Histidine-Proline-Lysine-Glutamine-Histidine-Arginine or VHPKQHR) was identified via phage display and targets vascular endothelial cells through the vascular cell adhesion molecule-1 (VCAM-1).	Lysine	44-50	vascular cell adhesion molecule 1	Homo sapiens	211-217
25492968-9	2014	In particular, we focus on HDAC2, which plays a central role in coupling lysine acetylation to synaptic plasticity and mediates many of the effects of HDAC inhibition in cognition and disease.	Lysine	73-79	histone deacetylase 2	Homo sapiens	27-32
24962734-12	2014	Decreased levels of active chromatin signs (acetylation of histone H3 lysines, H3K4me1/3, and H3K36me3) in TNF-alpha promoter were compatible with the expressions of TNF-alpha.	Lysine	70-77	tumor necrosis factor	Rattus norvegicus	107-116
25271152-4	2014	HDAC5 overexpression decreases BMAL1 acetylation on Lys-537 and pharmacological inhibition of class IIa HDACs increases BMAL1 acetylation.	Lysine	52-55	histone deacetylase 5	Mus musculus	0-5
25271152-4	2014	HDAC5 overexpression decreases BMAL1 acetylation on Lys-537 and pharmacological inhibition of class IIa HDACs increases BMAL1 acetylation.	Lysine	52-55	cycle	Drosophila melanogaster	31-36
25456412-1	2014	DPY-30 is a subunit of mammalian COMPASS-like complexes (complex of proteins associated with Set1) and regulates global histone H3 Lys-4 trimethylation.	Lysine	131-134	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	93-97
25218134-5	2014	In addition, we also employed genetic approaches by ablating both the eIF5A protein itself and DHS, the rate limiting enzyme catalyzing the conversion of lysine to hypusine.	Lysine	154-160	deoxyhypusine synthase	Homo sapiens	95-98
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	Lysine	137-143	ECB2	Homo sapiens	55-58
25382779-0	2014	Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.	Lysine	0-6	mitogen-activated protein kinase 3	Homo sapiens	77-80
24962734-12	2014	Decreased levels of active chromatin signs (acetylation of histone H3 lysines, H3K4me1/3, and H3K36me3) in TNF-alpha promoter were compatible with the expressions of TNF-alpha.	Lysine	70-77	tumor necrosis factor	Rattus norvegicus	166-175
25187573-13	2014	The more positively charged lysine and arginine residues in the N and C termini suggest that synovial lubricin exists as an amphoteric molecule.	Lysine	28-34	proteoglycan 4	Homo sapiens	102-110
25448412-0	2014	Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues.	Lysine	73-79	MAF bZIP transcription factor	Homo sapiens	43-48
25448412-2	2014	Theoretically, any lysine residues in c-MAF could be ubiquitinated.	Lysine	19-25	MAF bZIP transcription factor	Homo sapiens	38-43
25448412-3	2014	In the present study, we tried to find out the specific lysine residue(s) mediating c-MAF ubiquitination.	Lysine	56-62	MAF bZIP transcription factor	Homo sapiens	84-89
25319795-0	2014	Obesity increases histone H3 lysine 9 and 18 acetylation at Tnfa and Ccl2 genes in mouse liver.	Lysine	29-35	tumor necrosis factor	Mus musculus	60-64
25448412-9	2014	Therefore, we demonstrated that c-MAF ubiquitination is mediated by multiple lysine residues, of which K85 and K350 were sufficient but not the only residues in mediating c-MAF ubiquitination.	Lysine	77-83	MAF bZIP transcription factor	Homo sapiens	32-37
25123533-2	2014	Although many lysine acetyltransferases (KATs) have been characterized as being capable of acetylating multiple lysine residues on histones, how different factors such as enzyme complexes or external stimuli (e.g. KAT activators or inhibitors) alter KAT specificity remains elusive.	Lysine	14-20	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	41-44
25123533-2	2014	Although many lysine acetyltransferases (KATs) have been characterized as being capable of acetylating multiple lysine residues on histones, how different factors such as enzyme complexes or external stimuli (e.g. KAT activators or inhibitors) alter KAT specificity remains elusive.	Lysine	14-20	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	214-217
25336644-2	2014	Upon the loss of mitochondrial membrane potential (DeltaPsim), Lys-63-linked polyubiquitin chains accumulate on the mitochondrial outer membrane in a Parkin-dependent manner.	Lysine	63-66	parkin	Drosophila melanogaster	150-156
25253781-0	2014	A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.	Lysine	37-43	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-10
25253781-1	2014	The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27).	Lysine	89-95	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-8
25336644-4	2014	Here, we report that the suppression of Lys-63-linked polyubiquitination through the removal of Ubc13 activity essentially affects neither PINK1 activation nor the degradation of depolarized mitochondria.	Lysine	40-43	bendless	Drosophila melanogaster	96-101
25268658-4	2014	Two-dimensional 1H-15N HSQC spectra of [15N]-alpha-lysine-labeled rhodopsin in which signals arise primarily from residues in the cytoplasmic (CP) domain and of [15N]-alpha,epsilon-tryptophan-labeled rhodopsin in which signals arise only from transmembrane (TM) and extracellular (EC) residues indicate qualitatively that EC and CP domains may be differentially affected by denaturation.	Lysine	45-57	rhodopsin	Homo sapiens	66-75
25369470-1	2014	Polycomb Repressive Complex 2 (PRC2) modulates the chromatin structure and transcriptional repression by trimethylation lysine 27 of histone H3 (H3K27me3), a process that necessitates the protein-protein interaction (PPI) between the catalytic subunit EZH2 and EED.	Lysine	120-126	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	252-256
25268658-4	2014	Two-dimensional 1H-15N HSQC spectra of [15N]-alpha-lysine-labeled rhodopsin in which signals arise primarily from residues in the cytoplasmic (CP) domain and of [15N]-alpha,epsilon-tryptophan-labeled rhodopsin in which signals arise only from transmembrane (TM) and extracellular (EC) residues indicate qualitatively that EC and CP domains may be differentially affected by denaturation.	Lysine	45-57	rhodopsin	Homo sapiens	200-209
25154026-1	2014	EZH2 and EZH1 are protein methyltransferases (PMTs) responsible for histone H3, lysine 27 (H3K27) methylation.	Lysine	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25419572-4	2014	However, little is known about the reactivity and location of the glutamine and lysine residues involved in the TG2-mediated modification of OPN.	Lysine	80-86	transglutaminase 2	Homo sapiens	112-115
25387577-1	2014	DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone H3 (H3K79).	Lysine	79-85	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
25457180-4	2014	Surprisingly, our EZH2 inhibitors selectively affect the turnover of trimethylated, but not monomethylated histone H3 lysine 27 at pharmacologically relevant doses.	Lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	18-22
25297875-4	2014	When expanded from bone marrow precursors, moDCs were enriched at the Ccr7 locus for trimethylation of histone 3 lysine 27 (H3K27me3), a modification associated with transcriptional repression.	Lysine	113-119	chemokine (C-C motif) receptor 7	Mus musculus	70-74
25320281-10	2014	In addition, the TBX5 locus was enriched in activating chromatin marks, such as histone 4 lysine 4 trimethylation and histone acetylation, in RASF.	Lysine	90-96	T-box transcription factor 5	Homo sapiens	17-21
24967754-1	2014	Herein, we report a novel third-generation H2O2 and IO3- biosensor, which was fabricated by loading catalase (CAT) onto l-lysine/multiwalled carbon nanotube (PLL/f-MWCNT) film modified glassy carbon electrode (GCE).	Lysine	120-128	catalase	Homo sapiens	100-108
24967754-1	2014	Herein, we report a novel third-generation H2O2 and IO3- biosensor, which was fabricated by loading catalase (CAT) onto l-lysine/multiwalled carbon nanotube (PLL/f-MWCNT) film modified glassy carbon electrode (GCE).	Lysine	120-128	catalase	Homo sapiens	110-113
25369635-5	2014	We found that Sirt1, Sirt2, and Sirt3 can catalyze the hydrolysis of lysine crotonylated histone peptides and proteins.	Lysine	69-75	sirtuin 3	Homo sapiens	32-37
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	25-31	sirtuin 3	Homo sapiens	0-5
25518963-4	2014	By coupling the specific binding motif glutamate-urea-lysine with the chelator HBED-CC, which complexes Ga-68 very effectively, a new radiopharmaceutical is available for Ga-68-PSMA-PET/CT.	Lysine	54-60	folate hydrolase 1	Homo sapiens	177-181
24878542-0	2014	GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.	Lysine	129-135	GATA binding protein 4	Mus musculus	0-5
24878542-2	2014	Here, we tested the hypothesis that GATA4 promotes a jejunal versus ileal identity in mouse intestine by directly activating and repressing specific subsets of absorptive enterocyte genes by modulating the acetylation of histone H3, lysine 27 (H3K27), a mark of active chromatin, at sites of GATA4 occupancy.	Lysine	233-239	GATA binding protein 4	Mus musculus	36-41
25286347-10	2014	From biodistribution and ex vivo autoradiography studies, coadministration of both lysine and PA with [(177)Lu]DOTA-GRP(13-27) appeared to induce a clear improvement of tumor uptake as well as lower levels of renal radioactivity, causing a promising ninefold increase in tumor/kidney ratios.	Lysine	83-89	gastrin releasing peptide	Mus musculus	116-119
25070368-4	2014	In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH.	Lysine	57-63	STAM binding protein	Homo sapiens	152-156
25331887-6	2014	Nuclear accumulation of WWOX is regulated by its K63-linked ubiquitination at lysine residue 274, which is mediated by the E3 ubiquitin ligase ITCH.	Lysine	78-84	WW domain containing oxidoreductase	Homo sapiens	24-28
25331887-6	2014	Nuclear accumulation of WWOX is regulated by its K63-linked ubiquitination at lysine residue 274, which is mediated by the E3 ubiquitin ligase ITCH.	Lysine	78-84	itchy E3 ubiquitin protein ligase	Homo sapiens	143-147
25014164-4	2014	Here we show that the histone 3 lysine 4- and lysine 36-specific methyltransferase Smyd2 acts as an endogenous antagonistic player of p53-dependent cardiomyocyte apoptosis.	Lysine	32-38	tumor protein p53	Homo sapiens	134-137
25014164-4	2014	Here we show that the histone 3 lysine 4- and lysine 36-specific methyltransferase Smyd2 acts as an endogenous antagonistic player of p53-dependent cardiomyocyte apoptosis.	Lysine	46-52	tumor protein p53	Homo sapiens	134-137
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Lysine	194-197	albumin	Homo sapiens	63-66
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Lysine	194-197	albumin	Homo sapiens	217-220
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Lysine	206-209	albumin	Homo sapiens	63-66
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Lysine	206-209	albumin	Homo sapiens	217-220
24898729-5	2014	This interaction was mediated by two crucial residues, lysine 52 and tyrosine 63, of AH2, and was regulated by the AH1 domain.	Lysine	55-61	zinc finger RANBP2-type containing 3	Homo sapiens	85-88
25130613-2	2014	The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase-dependent cyanate (CNO-) formation.	Lysine	40-46	myeloperoxidase	Homo sapiens	141-156
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	25-31	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	19-22
25360633-6	2014	The differences of amino acids were characterised at sites of 119 leucine and 146 lysine with KPC-15 and KPC-2.	Lysine	82-88	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	105-110
25217633-4	2014	An analysis by mass spectroscopy indicated that U-STAT3 is acetylated on Lys-685, and the integrity of Lys-685 is required for the expression of most U-STAT3-dependent genes.	Lysine	73-76	signal transducer and activator of transcription 3	Homo sapiens	50-55
25217633-4	2014	An analysis by mass spectroscopy indicated that U-STAT3 is acetylated on Lys-685, and the integrity of Lys-685 is required for the expression of most U-STAT3-dependent genes.	Lysine	103-106	signal transducer and activator of transcription 3	Homo sapiens	152-157
25217633-5	2014	In contrast, we found only a very minor role for Lys-685 in gene expression induced in response to tyrosine-phosphorylated STAT3.	Lysine	49-52	signal transducer and activator of transcription 3	Homo sapiens	123-128
25217633-7	2014	Mutation of Lys-685 inhibits this function of STAT3, providing new information on the role of U-STAT3 in augmenting the development of heart failure.	Lysine	12-15	signal transducer and activator of transcription 3	Homo sapiens	46-51
25217633-7	2014	Mutation of Lys-685 inhibits this function of STAT3, providing new information on the role of U-STAT3 in augmenting the development of heart failure.	Lysine	12-15	signal transducer and activator of transcription 3	Homo sapiens	96-101
25240618-5	2014	In addition to the Lys20 sumoylation site, five potential acceptor lysine residues in USP were predicted and verified.	Lysine	67-73	ultraspiracle	Drosophila melanogaster	86-89
25179367-3	2014	The polycomb repressive complex 2 (PRC2) is a key epigenetic regulator that catalyses trimethylation of lysine 27 on histone H3 (H3K27me3) via the histone methyltransferase, EZH2, which confers stemness and regulates differentiation during embryonic development.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	174-178
25348414-11	2014	Mutation of one (or both) of the Walker A lysines in the catalytic site of the nucleotide-binding domains of SUR1 may have a similar effect to gliclazide on MgADP binding and transduction, but it does not appear to impair MgATP binding.	Lysine	42-49	ATP-binding cassette sub-family C member 8	Xenopus laevis	109-113
25217633-0	2014	Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.	Lysine	18-24	signal transducer and activator of transcription 3	Homo sapiens	98-103
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Lysine	69-75	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	79-85
25178721-11	2014	The in-source fragmentation experiments revealed that SFN is binding to free NH(2) groups (N-terminal amino acid and lysines) in Abeta.	Lysine	117-124	amyloid beta precursor protein	Homo sapiens	129-134
25178721-13	2014	CONCLUSIONS: The interaction of SFN, an anticancer agent, with Abeta was studied using ESI-MS. SFN is found to bind covalently and specifically with the free NH(2) group of N-terminal aspartic acid and the epsilon-amino group of lysine at positions 16 and 28.	Lysine	229-235	amyloid beta precursor protein	Homo sapiens	63-68
25355358-2	2014	This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys 119 using its E3 ubiquitin ligase subunits, Ring1B and Bmi1, together with an E2 ubiquitin-conjugating enzyme, UbcH5c.	Lysine	106-109	ubiquitin conjugating enzyme E2 D3	Homo sapiens	221-227
25196843-6	2014	Alanine substitutions at HO-2 residues Leu-201 and Lys-169 cause a respective 3- and 22-fold increase in K(m) values for CPR, consistent with a role for these residues in CPR binding.	Lysine	51-54	cytochrome p450 oxidoreductase	Homo sapiens	121-124
25204660-2	2014	PHF2 and PHF8 belong to a subfamily of histone demethylases that also possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus.	Lysine	129-135	PHD finger protein 2	Homo sapiens	0-4
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Lysine	69-75	glutamate receptor, ionotropic, kainate 3	Mus musculus	224-230
25196843-6	2014	Alanine substitutions at HO-2 residues Leu-201 and Lys-169 cause a respective 3- and 22-fold increase in K(m) values for CPR, consistent with a role for these residues in CPR binding.	Lysine	51-54	cytochrome p450 oxidoreductase	Homo sapiens	171-174
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Lysine	214-220	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	79-85
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Lysine	214-220	glutamate receptor, ionotropic, kainate 3	Mus musculus	104-110
25193666-8	2014	Molecular docking studies suggested that residue 74 corresponding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis experiments demonstrated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.	Lysine	214-220	glutamate receptor, ionotropic, kainate 3	Mus musculus	224-230
25288756-6	2014	Ras signaling selectively inactivates p53-mediated induction of p21Cip1 expression by inhibiting acetylation of specific lysine residues in the p53 DNA binding domain.	Lysine	121-127	tumor protein p53	Homo sapiens	38-41
25132549-4	2014	Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL.	Lysine	45-51	lysine demethylase 6A	Homo sapiens	86-89
25341359-5	2014	The putative NLS of c-Met is unique in that it relies on histidines, whose positive charge changes depending on pH, rather than the lysines or arginines, commonly found in classical bipartite NLSs, suggesting the possible "pH-dependency" of this NLS.	Lysine	132-139	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
25341040-1	2014	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
25341040-1	2014	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27.	Lysine	168-174	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
25341040-5	2014	In this study, we found that EZH2 suppresses miR-31 expression by trimethylation of lysine 27 on histone 3 on the miR-31 promoter.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
25288756-6	2014	Ras signaling selectively inactivates p53-mediated induction of p21Cip1 expression by inhibiting acetylation of specific lysine residues in the p53 DNA binding domain.	Lysine	121-127	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-71
25288756-6	2014	Ras signaling selectively inactivates p53-mediated induction of p21Cip1 expression by inhibiting acetylation of specific lysine residues in the p53 DNA binding domain.	Lysine	121-127	tumor protein p53	Homo sapiens	144-147
25288756-7	2014	Proliferation of cells lacking both Ras proteins and p53 can be prevented by reexpression of the human p53 ortholog, provided that it retains an active DNA binding domain and an intact lysine residue at position 164.	Lysine	185-191	tumor protein p53	Homo sapiens	53-56
25288756-7	2014	Proliferation of cells lacking both Ras proteins and p53 can be prevented by reexpression of the human p53 ortholog, provided that it retains an active DNA binding domain and an intact lysine residue at position 164.	Lysine	185-191	tumor protein p53	Homo sapiens	103-106
25170076-5	2014	First, we generated high purity apoA-I from human plasma, using thiophilic interaction chromatography followed by enzymatic digestion specifically at lysine or arginine residues.	Lysine	150-156	apolipoprotein A1	Homo sapiens	32-38
25314079-4	2014	CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation.	Lysine	49-55	CREB binding protein	Homo sapiens	0-3
25314079-4	2014	CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation.	Lysine	49-55	snail family transcriptional repressor 1	Homo sapiens	19-24
25314079-4	2014	CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation.	Lysine	49-55	snail family transcriptional repressor 1	Homo sapiens	40-45
25314079-4	2014	CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation.	Lysine	64-70	CREB binding protein	Homo sapiens	0-3
25314079-4	2014	CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation.	Lysine	64-70	snail family transcriptional repressor 1	Homo sapiens	19-24
25287450-9	2014	Furthermore, chromatin immuno-precipitation analysis showed that in the transgenic rescued lines (fld background), the levels of both tri-methylation of histone H3 Lys-4 and acetylation of H4 decreased significantly around the transcriptional start site of FLC.	Lysine	164-167	protein FLOWERING locus D-like protein	Arabidopsis thaliana	98-101
24594358-4	2014	Here we present the crystal structure of SMYD2 in complex with a target lysine (Lys266)-containing ERalpha peptide.	Lysine	72-78	estrogen receptor 1	Homo sapiens	99-106
24594358-5	2014	The structure reveals that ERalpha binds SMYD2 in a U-shaped conformation with the binding specificity determined mainly by residues C-terminal to the target lysine.	Lysine	158-164	estrogen receptor 1	Homo sapiens	27-34
25088689-1	2014	Enhancer of Zeste homolog 2 (EZH2), a methyltransferase specific to histone 3 lysine 27, is a critical player in gene silencing and is overexpressed in breast cancer.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	0-27
25088689-1	2014	Enhancer of Zeste homolog 2 (EZH2), a methyltransferase specific to histone 3 lysine 27, is a critical player in gene silencing and is overexpressed in breast cancer.	Lysine	78-84	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	29-33
25166916-9	2014	This method has been used to study translocated NSD2 (a histone lysine methyltransferase that catalyzes the histone lysine 36 methylation) function with its overexpression in KMS11 multiple myeloma cells.	Lysine	64-70	nuclear receptor binding SET domain protein 2	Homo sapiens	48-52
25283148-1	2014	Abraxas brother 1 (ABRO1) has been reported to be a component of the BRISC complex, a multiprotein complex that specifically cleaves "Lys-63"-linked ubiquitin.	Lysine	134-137	abraxas 2, BRISC complex subunit	Homo sapiens	0-17
25332884-0	2014	Lysine suppresses myofibrillar protein degradation by regulating the autophagic-lysosomal system through phosphorylation of Akt in C2C12 cells.	Lysine	0-6	thymoma viral proto-oncogene 1	Mus musculus	124-127
25332884-3	2014	We previously showed that lysine (Lys) markedly suppressed myofibrillar protein degradation by inhibiting the autophagic-lysosomal system via the mammalian target of rapamycin (mTOR) and other signal molecules in C2C12 cells.	Lysine	26-32	mechanistic target of rapamycin kinase	Homo sapiens	146-175
25332884-3	2014	We previously showed that lysine (Lys) markedly suppressed myofibrillar protein degradation by inhibiting the autophagic-lysosomal system via the mammalian target of rapamycin (mTOR) and other signal molecules in C2C12 cells.	Lysine	26-32	mechanistic target of rapamycin kinase	Homo sapiens	177-181
25332884-3	2014	We previously showed that lysine (Lys) markedly suppressed myofibrillar protein degradation by inhibiting the autophagic-lysosomal system via the mammalian target of rapamycin (mTOR) and other signal molecules in C2C12 cells.	Lysine	34-37	mechanistic target of rapamycin kinase	Homo sapiens	146-175
25332884-3	2014	We previously showed that lysine (Lys) markedly suppressed myofibrillar protein degradation by inhibiting the autophagic-lysosomal system via the mammalian target of rapamycin (mTOR) and other signal molecules in C2C12 cells.	Lysine	34-37	mechanistic target of rapamycin kinase	Homo sapiens	177-181
25332884-5	2014	Lys induced the phosphorylation of Akt, but the suppressive effects of Lys on myofibrillar protein degradation and autophagy were completely abolished in the presence of Akt1/2 kinase inhibitor (Akti).	Lysine	0-3	thymoma viral proto-oncogene 1	Mus musculus	35-38
25332884-9	2014	Taken together, our results show that Lys suppresses myofibrillar protein degradation by the autophagic-lysosomal system through the phosphorylation of Akt in C2C12 cells.	Lysine	38-41	thymoma viral proto-oncogene 1	Mus musculus	152-155
25283148-1	2014	Abraxas brother 1 (ABRO1) has been reported to be a component of the BRISC complex, a multiprotein complex that specifically cleaves "Lys-63"-linked ubiquitin.	Lysine	134-137	abraxas 2, BRISC complex subunit	Homo sapiens	19-24
25257467-1	2014	Plant homeodomain finger protein 2 (PHF2), which contains a plant homeodomain and a Jumonji-C domain, is an epigenetic regulator that demethylates lysine 9 in histone 3 (H3K9me2).	Lysine	147-153	PHD finger protein 2	Mus musculus	0-34
24930029-6	2014	This showed that both affected subjects have a heterozygous A &gt; T substitution at nucleotide 727 of the TITF1 gene changing lysine to a stop codon at residue 211.	Lysine	127-133	NK2 homeobox 1	Homo sapiens	107-112
25257467-1	2014	Plant homeodomain finger protein 2 (PHF2), which contains a plant homeodomain and a Jumonji-C domain, is an epigenetic regulator that demethylates lysine 9 in histone 3 (H3K9me2).	Lysine	147-153	PHD finger protein 2	Mus musculus	36-40
25309720-5	2014	Mounting evidence demonstrates that aberrant Akt activation can be attributed to other posttranslational modifications, which include tyrosine phosphorylation, O-GlcNAcylation, as well as lysine modifications: ubiquitination, SUMOylation and acetylation.	Lysine	188-194	AKT serine/threonine kinase 1	Homo sapiens	45-48
25149548-1	2014	Deregulation of histone H3 trimethylation at lysine 27 (H3K27me3) via aberration of the histone methyltransferase, enhancer of zeste homologue 2 (EZH2), is suggested to play a critical role in cancers including hematologic malignancies.	Lysine	45-51	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	115-144
25313314-5	2014	EZH2, a subunit of the polycomb repressive complex 2, catalyzes the methylation of histone H3 lysine 27 (H3K27) to H3K27me3.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
25149548-1	2014	Deregulation of histone H3 trimethylation at lysine 27 (H3K27me3) via aberration of the histone methyltransferase, enhancer of zeste homologue 2 (EZH2), is suggested to play a critical role in cancers including hematologic malignancies.	Lysine	45-51	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	146-150
25180930-5	2014	Efficient inhibition is dependent on (1) hydrophobic lysine isosteres blocking the active site, (2) proximal residues, and (3) the H3 tail forming extensive contacts with the EZH2 subunit of PRC2.	Lysine	53-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	175-179
25172487-6	2014	The ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex.	Lysine	41-47	NLR family pyrin domain containing 3	Homo sapiens	107-112
24990321-7	2014	PAR-4-mediated induction of COX-2 was prevented by the PI3K inhibitor LY (10 muM).	Lysine	70-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
24910389-5	2014	Mechanistically, p14(ARF) stabilizes SLUG through increased sumoylation at lysine residue 192.	Lysine	75-81	cyclin dependent kinase inhibitor 2A	Homo sapiens	17-20
25135975-1	2014	The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wide scale is broadly associated with active gene expression, with its mono-, di- and trimethylated forms differentially enriched at promoter and enhancer and other regulatory sequences.	Lysine	240-246	aristaless related homeobox	Homo sapiens	119-122
25071154-2	2014	Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histone H3 lysine 4.	Lysine	143-149	lysine demethylase 6A	Homo sapiens	59-62
25071154-2	2014	Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histone H3 lysine 4.	Lysine	195-201	lysine demethylase 6A	Homo sapiens	59-62
25071154-6	2014	Our results show that UTX is important for RAR-mediated transcription and provide insight into the critical role of cross talk between histone H3 lysine 4 methylation and histone H3 lysine 27 demethylation during cellular differentiation.	Lysine	146-152	lysine demethylase 6A	Homo sapiens	22-25
25071154-6	2014	Our results show that UTX is important for RAR-mediated transcription and provide insight into the critical role of cross talk between histone H3 lysine 4 methylation and histone H3 lysine 27 demethylation during cellular differentiation.	Lysine	182-188	lysine demethylase 6A	Homo sapiens	22-25
25267112-3	2014	Here we show that Jumonji-C domain-containing protein JMJ30 directly binds to the flowering-repressor FLOWERING LOCUS C (FLC) locus and removes the repressive histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	183-189	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	121-124
25107905-1	2014	Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKbeta), the critical activating kinase in canonical (NFkappaB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma.	Lysine	27-33	nuclear factor kappa B subunit 1	Homo sapiens	125-133
25170678-3	2014	Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer catalyzes the ubiquitination of histone H2B at lysine 120.	Lysine	159-165	ring finger protein 20	Homo sapiens	88-93
25086033-6	2014	Mammalian NKCCs are regulated by a kinase cascade consisting of the with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinases.	Lysine	76-82	Wnk kinase	Drosophila melanogaster	84-87
25170678-3	2014	Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer catalyzes the ubiquitination of histone H2B at lysine 120.	Lysine	159-165	ring finger protein 40	Homo sapiens	94-99
25056130-1	2014	We constructed dimeric alpha-helical peptide bundles based on leucine (L) and lysine (K) residues for both efficient cell penetration and inhibition of the Tat-TAR interaction.	Lysine	78-84	RNA binding motif protein 8A	Homo sapiens	160-163
25278939-3	2014	C1s has a Lys residue located at position 628 (192 in chymotrypsin numbering) of the SP domain that has the potential to partially occlude the S2-S2" positions of the active site.	Lysine	10-13	complement C1s	Homo sapiens	0-3
24996493-6	2014	Lys administration also induced a decrease of all antioxidant enzyme activities in the brain, as well as an increase of the activities of SOD and CAT in the liver of Gcdh(-/-) mice.	Lysine	0-3	catalase	Mus musculus	146-149
25225064-2	2014	Our objective is to characterize alterations observed by exome sequencing and sequencing of the TERT promoter, and to examine the functional relevance of histone lysine (K)-specific demethylase 6A (KDM6A/UTX), a frequently mutated histone demethylase, in bladder cancer.	Lysine	162-168	lysine demethylase 6A	Homo sapiens	198-203
25059665-4	2014	The increase in t-PA activity is the result of a mechanism involving a t-PA lysine-dependent binding site in the GRP78 amino acid sequence (98)LIGRTWNDPSVQQDIKFL(115).	Lysine	76-82	plasminogen activator, tissue type	Homo sapiens	16-20
25008320-4	2014	We show lysine acetylation (acetyl-Lys)-dependent activation of AMP-activated protein kinase, AKT, and PKA kinases during ischemia.	Lysine	8-14	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
25056949-2	2014	We have shown previously that, following TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a regulatory role in TNFR signaling.	Lysine	104-107	tumor necrosis factor	Homo sapiens	41-44
25056949-4	2014	This regulatory function toward JNK activation but not NF-kappaB activation depends on lysine 105 of TTP, which we identified as the corresponding TRAF2 ubiquitination site.	Lysine	87-93	mitogen-activated protein kinase 8	Homo sapiens	32-35
25059665-4	2014	The increase in t-PA activity is the result of a mechanism involving a t-PA lysine-dependent binding site in the GRP78 amino acid sequence (98)LIGRTWNDPSVQQDIKFL(115).	Lysine	76-82	plasminogen activator, tissue type	Homo sapiens	71-75
25059665-4	2014	The increase in t-PA activity is the result of a mechanism involving a t-PA lysine-dependent binding site in the GRP78 amino acid sequence (98)LIGRTWNDPSVQQDIKFL(115).	Lysine	76-82	heat shock protein family A (Hsp70) member 5	Homo sapiens	113-118
25188294-2	2014	Whsc1 (Wolf-Hirschhorn Syndrome candidate 1), a histone H3 lysine 36 (H3K36) trimethyltransferase, is one of the major genes associated with Wolf-Hirshhorn syndrome, which is characterized by skeletal abnormalities.	Lysine	59-65	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
25127513-3	2014	Here, we show that isomerization of H3 at the alanine 15-proline 16 (A15-P16) peptide bond is influenced by lysine 14 (K14) and controls gene-specific K4me3 by balancing the actions of Jhd2, the K4me3 demethylase, and Spp1, a subunit of the Set1 K4 methyltransferase complex.	Lysine	108-114	cyclin dependent kinase inhibitor 2A	Homo sapiens	73-76
25188243-2	2014	MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and its overexpression causes a global increase in H3K36me2, redistributing this mark in a broad, elevated level across the genome.	Lysine	33-39	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
25188243-3	2014	Here, we demonstrate that an increased level of MMSET also induces a global reduction of lysine 27 trimethylation on histone H3 (H3K27me3).	Lysine	89-95	nuclear receptor binding SET domain protein 2	Homo sapiens	48-53
25188294-2	2014	Whsc1 (Wolf-Hirschhorn Syndrome candidate 1), a histone H3 lysine 36 (H3K36) trimethyltransferase, is one of the major genes associated with Wolf-Hirshhorn syndrome, which is characterized by skeletal abnormalities.	Lysine	59-65	nuclear receptor binding SET domain protein 2	Homo sapiens	7-43
25181347-7	2014	Consistently, a significant reduction of lysine-specific demethylase KDM2A could be found after eight weeks of TAC at the Atp2a2 promoter.	Lysine	41-47	lysine (K)-specific demethylase 2A	Mus musculus	69-74
24912753-6	2014	At low concentrations of homocysteine thiolactone, modification of GAPDH leads not only to prevention of spontaneous inactivation but also increases thermal stability of this enzyme on heating to 80 C. A moderate reduction of the activity of GAPDH observed in case of its crosslinking with 50-fold excess of homocysteine thiolactone per lysine is probably caused by hindered substrate diffusion.	Lysine	337-343	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	67-72
25015965-0	2014	Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.	Lysine	69-75	nitric oxide synthase 3	Bos taurus	93-106
25015965-2	2014	Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium.	Lysine	99-105	nitric oxide synthase 3	Bos taurus	23-51
25015965-2	2014	Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium.	Lysine	99-105	nitric oxide synthase 3	Bos taurus	53-57
25015965-2	2014	Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium.	Lysine	99-105	nitric oxide synthase 3	Bos taurus	59-74
25015965-3	2014	We tested the hypothesis that NOS3 is lysine acetylated and that upregulated HDAC1-mediated deacetylation leads to reduced NO production in endothelial cells.	Lysine	38-44	nitric oxide synthase 3	Bos taurus	30-34
25015965-4	2014	We determined that NOS3 is basally lysine acetylated in cultured bovine aortic endothelial cells (BAECs).	Lysine	35-41	nitric oxide synthase 3	Bos taurus	19-23
25015965-9	2014	Thus these data indicate that upregulated HDAC1 decreases NOS3 activity, most likely through direct lysine deacetylation of NOS3.	Lysine	100-106	nitric oxide synthase 3	Bos taurus	58-62
25015965-9	2014	Thus these data indicate that upregulated HDAC1 decreases NOS3 activity, most likely through direct lysine deacetylation of NOS3.	Lysine	100-106	nitric oxide synthase 3	Bos taurus	124-128
24912753-6	2014	At low concentrations of homocysteine thiolactone, modification of GAPDH leads not only to prevention of spontaneous inactivation but also increases thermal stability of this enzyme on heating to 80 C. A moderate reduction of the activity of GAPDH observed in case of its crosslinking with 50-fold excess of homocysteine thiolactone per lysine is probably caused by hindered substrate diffusion.	Lysine	337-343	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	242-247
25115397-3	2014	Here, we demonstrate that ID4 promoter methylation is initiated by EZH2 dependent tri-methylation of histone 3 at lysine 27 (H3K27me3).	Lysine	114-120	inhibitor of DNA binding 4, HLH protein	Homo sapiens	26-29
24760766-4	2014	Here, we report that the zinc-finger protein ZNF274, in association with the histone H3 lysine 9 (H3K9) methyltransferase SETDB1, is part of a complex that binds to the silent maternal but not the active paternal alleles.	Lysine	88-94	zinc finger protein 274	Homo sapiens	45-51
24760766-4	2014	Here, we report that the zinc-finger protein ZNF274, in association with the histone H3 lysine 9 (H3K9) methyltransferase SETDB1, is part of a complex that binds to the silent maternal but not the active paternal alleles.	Lysine	88-94	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	122-128
24760766-5	2014	Knockdown of SETDB1 in PWS-specific induced pluripotent cells (iPSCs) causes a decrease in the accumulation of H3K9 trimethylation (H3K9me3) at 116HG and corresponding accumulation of the active chromatin mark histone H3 lysine 4 dimethylation (H3K4me2).	Lysine	221-227	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	13-19
25177965-7	2014	The putatively acetylated lysine residues that regulate MDH activity were also conserved at K118, K121, and K298 in MDH1, and K185, K301, K307, and K314 in MDH2.	Lysine	26-32	malate dehydrogenase 1	Felis catus	56-59
25177965-7	2014	The putatively acetylated lysine residues that regulate MDH activity were also conserved at K118, K121, and K298 in MDH1, and K185, K301, K307, and K314 in MDH2.	Lysine	26-32	malate dehydrogenase 1	Felis catus	116-120
24531926-5	2014	Furthermore, malonyl-CoA decarboxylase (MCD) deficient patient cells had increased levels of malonylated lysines and propionyl-CoA carboxylase (PCC) deficient patient cells had increased propionylation of lysines.	Lysine	105-112	malonyl-CoA decarboxylase	Homo sapiens	13-38
24531926-5	2014	Furthermore, malonyl-CoA decarboxylase (MCD) deficient patient cells had increased levels of malonylated lysines and propionyl-CoA carboxylase (PCC) deficient patient cells had increased propionylation of lysines.	Lysine	105-112	malonyl-CoA decarboxylase	Homo sapiens	40-43
24531926-5	2014	Furthermore, malonyl-CoA decarboxylase (MCD) deficient patient cells had increased levels of malonylated lysines and propionyl-CoA carboxylase (PCC) deficient patient cells had increased propionylation of lysines.	Lysine	205-212	malonyl-CoA decarboxylase	Homo sapiens	13-38
24531926-5	2014	Furthermore, malonyl-CoA decarboxylase (MCD) deficient patient cells had increased levels of malonylated lysines and propionyl-CoA carboxylase (PCC) deficient patient cells had increased propionylation of lysines.	Lysine	205-212	malonyl-CoA decarboxylase	Homo sapiens	40-43
25143216-5	2014	Using a guiding DNA strand modified with a metal-binding functionality, we directed a second DNA strand to the vicinity of a metal-binding site of His6-tagged or wild-type metal-binding proteins, such as serotransferrin, where it subsequently reacted with lysine residues at that site.	Lysine	256-262	transferrin	Homo sapiens	204-219
25177965-7	2014	The putatively acetylated lysine residues that regulate MDH activity were also conserved at K118, K121, and K298 in MDH1, and K185, K301, K307, and K314 in MDH2.	Lysine	26-32	malate dehydrogenase 2	Felis catus	156-160
25115397-3	2014	Here, we demonstrate that ID4 promoter methylation is initiated by EZH2 dependent tri-methylation of histone 3 at lysine 27 (H3K27me3).	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	67-71
25044612-2	2014	The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self-healing protein hydrogel system.	Lysine	56-62	catalase	Homo sapiens	80-83
25158603-3	2014	RESULTS: In this study, we have precisely mapped, by mass spectrometry experiments, the sites of protein acetylation and, by mutagenesis assays, we have described a set of acetylated lysines as being crucial in influencing the subcellular localization of AIRE.	Lysine	183-190	autoimmune regulator	Homo sapiens	255-259
25158603-4	2014	Furthermore, we have also determined that the de-acetyltransferase enzymes HDAC1-2 are involved in the lysine de-acetylation of AIRE.	Lysine	103-109	histone deacetylase 1	Homo sapiens	75-80
25158603-4	2014	Furthermore, we have also determined that the de-acetyltransferase enzymes HDAC1-2 are involved in the lysine de-acetylation of AIRE.	Lysine	103-109	autoimmune regulator	Homo sapiens	128-132
25158603-5	2014	CONCLUSIONS: On the basis of our results and those reported in literature, we propose a model in which lysines acetylation increases the stability of AIRE in the nucleus.	Lysine	103-110	autoimmune regulator	Homo sapiens	150-154
24853465-3	2014	In the course of model experiments, a striking potential of the amino acids L-arginine (Arg) and L-lysine (Lys) and a number of positively charged peptides to induce formation of heterogenic supramolecular structures of insulin was demonstrated under environment conditions where the protein aggregation in their absence was not observed.	Lysine	97-105	insulin	Homo sapiens	220-227
24853465-3	2014	In the course of model experiments, a striking potential of the amino acids L-arginine (Arg) and L-lysine (Lys) and a number of positively charged peptides to induce formation of heterogenic supramolecular structures of insulin was demonstrated under environment conditions where the protein aggregation in their absence was not observed.	Lysine	107-110	insulin	Homo sapiens	220-227
25044612-2	2014	The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self-healing protein hydrogel system.	Lysine	56-62	albumin	Homo sapiens	96-109
25071177-5	2014	Our results reveal broad between-group differences in basal levels of trimethylated histone protein H3 at lysine 9 (H3K9me3) in hippocampus (HC), amygdala, and nucleus accumbens.	Lysine	106-112	H2B clustered histone 1	Rattus norvegicus	84-91
25088994-4	2014	Histone H3 lysine (K) 9 methylation, but not H3 K27 or K4 methylation, was involved in menin-dependent IL-6 regulation.	Lysine	11-17	multiple endocrine neoplasia 1	Mus musculus	87-92
25088994-4	2014	Histone H3 lysine (K) 9 methylation, but not H3 K27 or K4 methylation, was involved in menin-dependent IL-6 regulation.	Lysine	11-17	interleukin 6	Mus musculus	103-107
25148259-3	2014	Through simulating the dynamics of DAP12-NKG2C TM heterotrimer and point mutations, we demonstrated that a five-polar-residue motif including: 2 Asps and 2 Thrs in DAP12 dimer, as well as 1 Lys in NKG2C TM plays an important role in the assembly structure of the DAP12-NKG2C TM heterotrimer.	Lysine	190-193	killer cell lectin like receptor C2	Homo sapiens	41-46
25148259-3	2014	Through simulating the dynamics of DAP12-NKG2C TM heterotrimer and point mutations, we demonstrated that a five-polar-residue motif including: 2 Asps and 2 Thrs in DAP12 dimer, as well as 1 Lys in NKG2C TM plays an important role in the assembly structure of the DAP12-NKG2C TM heterotrimer.	Lysine	190-193	killer cell lectin like receptor C2	Homo sapiens	197-202
25148259-3	2014	Through simulating the dynamics of DAP12-NKG2C TM heterotrimer and point mutations, we demonstrated that a five-polar-residue motif including: 2 Asps and 2 Thrs in DAP12 dimer, as well as 1 Lys in NKG2C TM plays an important role in the assembly structure of the DAP12-NKG2C TM heterotrimer.	Lysine	190-193	killer cell lectin like receptor C2	Homo sapiens	197-202
25148519-10	2014	The two sites within proSAAS that are known to be efficiently cleaved by furin were altered by site-directed mutagenesis to convert the P4 Arg into Lys; this change converts the sequences from furin consensus sites into prohormone convertase consensus sites.	Lysine	148-151	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	21-28
24939842-6	2014	We identified that the acetylated lysines 5 and 8 of nucleosomal histone H4 (H4K5ac/K8ac) is the BRD4 binding site, and the protein phosphatase PP1alpha and class I histone deacetylase (HDAC1/2/3) signaling pathways are essential for the stress-induced BRD4 release from chromatin.	Lysine	34-41	bromodomain containing 4	Homo sapiens	97-101
24939842-6	2014	We identified that the acetylated lysines 5 and 8 of nucleosomal histone H4 (H4K5ac/K8ac) is the BRD4 binding site, and the protein phosphatase PP1alpha and class I histone deacetylase (HDAC1/2/3) signaling pathways are essential for the stress-induced BRD4 release from chromatin.	Lysine	34-41	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	144-152
24939842-6	2014	We identified that the acetylated lysines 5 and 8 of nucleosomal histone H4 (H4K5ac/K8ac) is the BRD4 binding site, and the protein phosphatase PP1alpha and class I histone deacetylase (HDAC1/2/3) signaling pathways are essential for the stress-induced BRD4 release from chromatin.	Lysine	34-41	histone deacetylase 1	Homo sapiens	186-195
24939842-6	2014	We identified that the acetylated lysines 5 and 8 of nucleosomal histone H4 (H4K5ac/K8ac) is the BRD4 binding site, and the protein phosphatase PP1alpha and class I histone deacetylase (HDAC1/2/3) signaling pathways are essential for the stress-induced BRD4 release from chromatin.	Lysine	34-41	bromodomain containing 4	Homo sapiens	253-257
25122478-9	2014	Stimulation of cells with EGF resulted in an increase in Akt phosphorylation at Ser473, which was inhibited by c-Src DN, DPI, and LY 294002.	Lysine	130-132	AKT serine/threonine kinase 1	Homo sapiens	57-60
25122677-4	2014	We analyzed genome-wide histone H3 lysine 4 methylation and gene expression in thyroid cells induced by IFNalpha, a key cytokine secreted during viral infections, and overlapped them with known GD-associated SNPs.	Lysine	35-41	interferon alpha 1	Homo sapiens	104-112
25156493-4	2014	ArhGAP30 binds to p53 C-terminal domain and P300, facilitating P300-mediated acetylation of p53 at lysine 382.	Lysine	99-105	tumor protein p53	Homo sapiens	18-21
25156493-4	2014	ArhGAP30 binds to p53 C-terminal domain and P300, facilitating P300-mediated acetylation of p53 at lysine 382.	Lysine	99-105	tumor protein p53	Homo sapiens	92-95
25153837-1	2014	ALKBH4, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, has previously been shown to regulate the level of monomethylated lysine-84 in actin and thereby indirectly influences the ability of non-muscular myosin II to bind actin filaments.	Lysine	153-159	alkB homolog 4, lysine demethylase	Mus musculus	0-6
25153837-1	2014	ALKBH4, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, has previously been shown to regulate the level of monomethylated lysine-84 in actin and thereby indirectly influences the ability of non-muscular myosin II to bind actin filaments.	Lysine	153-159	alkB homolog 1, histone H2A dioxygenase	Mus musculus	11-15
25042803-0	2014	Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.	Lysine	0-6	phosphogluconate dehydrogenase	Homo sapiens	29-61
25042803-2	2014	We found that 6PGD is commonly activated in EGF-stimulated cells and human cancer cells by lysine acetylation.	Lysine	91-97	phosphogluconate dehydrogenase	Homo sapiens	14-18
25042803-7	2014	Furthermore, 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.	Lysine	57-63	phosphogluconate dehydrogenase	Homo sapiens	13-17
24721162-11	2014	We further analyzed a STAT3 arginine-lysine-exchange mutant (R414K/R417K).	Lysine	37-43	signal transducer and activator of transcription 3	Homo sapiens	22-27
24213577-2	2014	The PcG protein Enhancer of Zeste Homolog 2 (EZH2) works as a catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) by methylating lysine 27 on histone H3 (H3K27me3), a hallmark of PRC2-mediated gene repression.	Lysine	139-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	16-43
24213577-2	2014	The PcG protein Enhancer of Zeste Homolog 2 (EZH2) works as a catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) by methylating lysine 27 on histone H3 (H3K27me3), a hallmark of PRC2-mediated gene repression.	Lysine	139-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-49
24803071-0	2014	PEGylation of lysine residues improves the proteolytic stability of fibronectin while retaining biological activity.	Lysine	14-20	fibronectin 1	Homo sapiens	68-79
24803071-6	2014	Here, we present an alternative approach in which FN is preferentially PEGylated at lysine residues using different molecular weight PEGs.	Lysine	84-90	fibronectin 1	Homo sapiens	50-52
24803071-12	2014	In summary, lysine PEGylation of FN can be used to stabilize FN against proteolytic degradation with minimal perturbation to FN structure and retained biological activity.	Lysine	12-18	fibronectin 1	Homo sapiens	33-35
24803071-12	2014	In summary, lysine PEGylation of FN can be used to stabilize FN against proteolytic degradation with minimal perturbation to FN structure and retained biological activity.	Lysine	12-18	fibronectin 1	Homo sapiens	61-63
24803071-12	2014	In summary, lysine PEGylation of FN can be used to stabilize FN against proteolytic degradation with minimal perturbation to FN structure and retained biological activity.	Lysine	12-18	fibronectin 1	Homo sapiens	61-63
24942738-7	2014	Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only.	Lysine	70-77	amino acid permease GAP1	Saccharomyces cerevisiae S288C	34-38
24942738-7	2014	Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only.	Lysine	79-82	amino acid permease GAP1	Saccharomyces cerevisiae S288C	34-38
25095792-4	2014	RESULTS: Three different molecular weight glycans (lactose and two dextrans with 1 kD and 10 kD) were chemically coupled to surface exposed Cyt c lysine (Lys) residues using succinimidyl chemistry via amide bonds.	Lysine	146-152	cytochrome c, somatic	Homo sapiens	140-145
25095792-4	2014	RESULTS: Three different molecular weight glycans (lactose and two dextrans with 1 kD and 10 kD) were chemically coupled to surface exposed Cyt c lysine (Lys) residues using succinimidyl chemistry via amide bonds.	Lysine	154-157	cytochrome c, somatic	Homo sapiens	140-145
24962578-5	2014	In particular, Tyr-381 phosphorylation of PDP1 dissociates deacetylase SIRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylation of PDHA1 and PDP1.	Lysine	156-162	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	42-46
24924945-2	2014	In an attempt to overcome the failed therapeutic impact of currently available antioxidants in cardiovascular disease, we developed a nanomedicine-based delivery system for the O2(-)-scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD), in which CuZnSOD protein is electrostatically bound to a poly-l-lysine (PLL50)-polyethylene glycol (PEG) block copolymer to form a CuZnSOD nanozyme.	Lysine	302-315	superoxide dismutase 1, soluble	Mus musculus	235-242
24924946-8	2014	Identification of 4-HNE and 4-ONE target residues in purified human GRP78 revealed a marked propensity for Lys and His adduction within the ATPase domain and a relative paucity of adduct formation within the peptide-binding domain.	Lysine	107-110	heat shock protein family A (Hsp70) member 5	Homo sapiens	68-73
24578127-9	2014	Furthermore, HDAC4 interference increased the acetylation status of histone H3 at lysine 9 (H3K9Ac), the enrichment of H3K9Ac in miR-29a proximal promoter, and miR-29a transcription in high glucose-stressed podocytes.	Lysine	82-88	histone deacetylase 4	Mus musculus	13-18
24962578-5	2014	In particular, Tyr-381 phosphorylation of PDP1 dissociates deacetylase SIRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylation of PDHA1 and PDP1.	Lysine	156-162	sirtuin 3	Homo sapiens	71-76
24962578-5	2014	In particular, Tyr-381 phosphorylation of PDP1 dissociates deacetylase SIRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylation of PDHA1 and PDP1.	Lysine	156-162	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	188-192
24831241-3	2014	We find that accessory (Lys -3, Trp -2, Ser -1 and Leu +2) and canonical (D -4, Leu 0 and Leu +1) residues confer the DKWSLLL signal with the versatility required for the Cu(+)-regulated cycling of ATP7B between the trans-Golgi network (TGN) and the plasma membrane (PM).	Lysine	24-27	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	32-38
25009642-2	2014	Astrocyte elevated gene-1 [AEG-1; also known as Metadherin (MTDH) and Lysine-rich CEACAM1 co-isolated (LYRIC)] has emerged in recent years as a potentially crucial mediator of tumor malignancy, and a key converging point of a complex network of oncogenic signaling pathways.	Lysine	70-76	metadherin	Homo sapiens	0-25
25009642-2	2014	Astrocyte elevated gene-1 [AEG-1; also known as Metadherin (MTDH) and Lysine-rich CEACAM1 co-isolated (LYRIC)] has emerged in recent years as a potentially crucial mediator of tumor malignancy, and a key converging point of a complex network of oncogenic signaling pathways.	Lysine	70-76	metadherin	Homo sapiens	27-32
24936062-0	2014	F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).	Lysine	119-125	mitogen-activated protein kinase 14	Homo sapiens	52-55
24936062-0	2014	F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).	Lysine	119-125	mitogen-activated protein kinase kinase 6	Homo sapiens	213-217
24936062-3	2014	Activation of the MKK6-p38 pathway is kept in check by multiple layers of regulations, including autoinhibition, dimerization, scaffold proteins, and Lys-63-linked polyubiquitination.	Lysine	150-153	mitogen-activated protein kinase kinase 6	Homo sapiens	18-22
24936062-3	2014	Activation of the MKK6-p38 pathway is kept in check by multiple layers of regulations, including autoinhibition, dimerization, scaffold proteins, and Lys-63-linked polyubiquitination.	Lysine	150-153	mitogen-activated protein kinase 14	Homo sapiens	23-26
24936062-7	2014	Our results show that FBXO31 binds to MKK6 and mediates its Lys-48-linked polyubiquitination and degradation, thereby functioning as a negative regulator of MKK6-p38 signaling and protecting cells from stress-induced cell apoptosis.	Lysine	60-63	mitogen-activated protein kinase kinase 6	Homo sapiens	38-42
24936062-7	2014	Our results show that FBXO31 binds to MKK6 and mediates its Lys-48-linked polyubiquitination and degradation, thereby functioning as a negative regulator of MKK6-p38 signaling and protecting cells from stress-induced cell apoptosis.	Lysine	60-63	mitogen-activated protein kinase kinase 6	Homo sapiens	157-161
24936062-7	2014	Our results show that FBXO31 binds to MKK6 and mediates its Lys-48-linked polyubiquitination and degradation, thereby functioning as a negative regulator of MKK6-p38 signaling and protecting cells from stress-induced cell apoptosis.	Lysine	60-63	mitogen-activated protein kinase 14	Homo sapiens	162-165
24097032-3	2014	The aim of our study is to examine the role of epigenetic chromatin marks, such as histone H3 lysine methylation (H3Kme), in bile duct ligation (BDL)-induced TGF-beta1 gene expression in rat liver.	Lysine	94-100	transforming growth factor, beta 1	Rattus norvegicus	158-167
24920161-6	2014	Through the identification of PARP-1 in vitro automodification sites as well as endogenous ADP-ribosylation sites from whole cells, we have shown that ADP-ribose can exist on adjacent amino acid residues as well as both lysine and arginine in addition to known acidic modification sites.	Lysine	220-226	poly(ADP-ribose) polymerase 1	Homo sapiens	30-36
24907272-8	2014	Taken together, we establish that the ARM is required for RNF4 to efficiently target Ser(P)-824-SUMO-KAP1, conferring ubiquitin Lys-48-mediated proteasomal degradation in the context of double strand breaks.	Lysine	128-131	tripartite motif containing 28	Homo sapiens	85-105
25072887-7	2014	For example, Acm1 degradation in G1 requires neither lysine residues in Acm1 nor assembly of polyubiquitin chains.	Lysine	53-59	Acm1p	Saccharomyces cerevisiae S288C	13-17
25061856-2	2014	The recruitment of Polycomb complexes to specific targets has been widely thought to occur in two steps: first, one complex, PRC2, produces histone H3 lysine 27 (H3K27) trimethylation at a specific gene, and then the PRC1 complex is recruited by its ability to bind to H3K27me3.	Lysine	151-157	protein regulator of cytokinesis 1	Mus musculus	217-221
25056273-4	2014	Here we report that the lysine residue in the PP1-binding motif of BRCA1 is highly conserved across many mammalian species.	Lysine	24-30	inorganic pyrophosphatase 1	Homo sapiens	46-49
25036361-0	2014	Sumoylation of human argonaute 2 at lysine-402 regulates its stability.	Lysine	36-42	argonaute RISC catalytic component 2	Homo sapiens	21-32
24939622-8	2014	In addition, immunoprecipitation analysis revealed that VPA increased the acetylation of GCPII protein at the lysine residues and facilitated a decrease of the poly-ubiquitinated GCPII level.	Lysine	110-116	folate hydrolase 1	Homo sapiens	89-94
24939622-11	2014	Taken together, this study demonstrated that the increase in GCPII induced by VPA is not due to the classical epigenetic mechanism, but via enhanced acetylation of lysine residues in GCPII.	Lysine	164-170	folate hydrolase 1	Homo sapiens	61-66
24939622-11	2014	Taken together, this study demonstrated that the increase in GCPII induced by VPA is not due to the classical epigenetic mechanism, but via enhanced acetylation of lysine residues in GCPII.	Lysine	164-170	folate hydrolase 1	Homo sapiens	183-188
24964018-0	2014	Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand.	Lysine	129-135	uncharacterized protein	Chlamydomonas reinhardtii	20-24
24964018-3	2014	We present mutagenesis, optical, and nuclear magnetic resonance data for the recombinant protein and show that at pH near neutral in the absence of added ligand, THB1 coordinates the heme iron with the canonical proximal histidine and a distal lysine.	Lysine	244-250	uncharacterized protein	Chlamydomonas reinhardtii	162-166
24821725-5	2014	shRNA knockdown of HDAC1, HDAC2, or HDAC3 differentially increases the deposition of the histone 3 lysine 27 acetylation (H3K27ac) epigenetic mark associated with increases in these three transcripts.	Lysine	99-105	histone deacetylase 1	Homo sapiens	19-24
24981174-6	2014	RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients.	Lysine	107-113	ring finger protein 126	Homo sapiens	0-6
24981175-5	2014	Mice fed a lysine-deficient diet for 2 days show decreased Akt activity, TKT activity, and purine synthesis in multiple organs.	Lysine	11-17	thymoma viral proto-oncogene 1	Mus musculus	59-62
24960425-1	2014	Rhodopsin is a G protein-coupled receptor specialized for photoreception and contains a light-absorbing chromophore retinal that binds to the lysine residue of opsin through a protonated Schiff base linkage.	Lysine	142-148	rhodopsin	Homo sapiens	0-9
25028718-1	2014	The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine) and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative stress-responsive kinase 1).	Lysine	73-79	serine/threonine kinase 39	Homo sapiens	8-12
25028718-1	2014	The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine) and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative stress-responsive kinase 1).	Lysine	73-79	odd-skipped related transcription factor 1	Homo sapiens	13-17
25027767-8	2014	Indeed, the homeostasis of the Imd scaffolding molecule is tightly regulated by the linkage of lysine 48-linked ubiquitin chains (K48) acting as a tag for its proteasomal degradation.	Lysine	95-101	immune deficiency	Drosophila melanogaster	31-34
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Lysine	78-85	bromodomain containing 4	Homo sapiens	115-119
24821725-5	2014	shRNA knockdown of HDAC1, HDAC2, or HDAC3 differentially increases the deposition of the histone 3 lysine 27 acetylation (H3K27ac) epigenetic mark associated with increases in these three transcripts.	Lysine	99-105	histone deacetylase 2	Homo sapiens	26-31
25007265-10	2014	p300 was recruited to the promoter regions of OCN and DSPP and might be acting as a coactivator to increase the acetylation of lysine 9 of histone H3 of OCN and DSPP.	Lysine	127-133	bone gamma-carboxyglutamate protein	Homo sapiens	46-49
25007265-10	2014	p300 was recruited to the promoter regions of OCN and DSPP and might be acting as a coactivator to increase the acetylation of lysine 9 of histone H3 of OCN and DSPP.	Lysine	127-133	bone gamma-carboxyglutamate protein	Homo sapiens	153-156
24991765-9	2014	We observed that the BH3 domain of Bax is critical for its recognition by parkin, and identified two lysines that are crucial for parkin-dependent regulation of Bax translocation.	Lysine	101-108	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38
24991765-9	2014	We observed that the BH3 domain of Bax is critical for its recognition by parkin, and identified two lysines that are crucial for parkin-dependent regulation of Bax translocation.	Lysine	101-108	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
24716439-8	2014	Molecular dynamics simulations also suggested that additional loss of iron binding capacity may result from the stereochemical effects induced by the glycation of lysine residues that prevent the conformational changes (from open to closed Tf forms) required for metal binding.	Lysine	163-169	transferrin	Homo sapiens	240-242
24988429-10	2014	Mutation of the dimerization motif resulted in a monomeric form of SULT4A1 that was rapidly degraded by polyubiquitination on the lysine located within the dimerization motif.	Lysine	130-136	sulfotransferase family 4A member 1	Homo sapiens	67-74
24595546-1	2014	The nuclear receptor SET domain-containing family of proteins (NSD1, NSD2, and NSD3) is known to mono- and dimethylate lysine 36 of histone H3 (H3K36).	Lysine	119-125	nuclear receptor binding SET domain protein 2	Homo sapiens	69-73
24726449-0	2014	Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell.	Lysine	38-44	DExH-box helicase 9	Homo sapiens	100-114
24726449-4	2014	METHODS: The conserved lysine residues in each or both of dsRBDs were substituted by alanine in the context of full-length RNA helicase A.	Lysine	23-29	DExH-box helicase 9	Homo sapiens	123-137
24726449-10	2014	CONCLUSIONS: The conserved lysine residues of dsRBDs play critical roles in the promotion of HIV-1 production by RNA helicase A.	Lysine	27-33	DExH-box helicase 9	Homo sapiens	113-127
24726449-11	2014	GENERAL SIGNIFICANCE: The conserved lysine residues of dsRBDs are key to the interaction of RNA helicase A with substrate RNA in the cell, but not in vitro.	Lysine	36-42	DExH-box helicase 9	Homo sapiens	92-106
24571482-10	2014	MOF/hMOF physically interacted with and acetylated Nrf2 at Lys(588) .	Lysine	59-62	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
24652950-2	2014	This study explored the role of G9a- and enhancer of zeste homolog 2 (EZH2)-mediated methylation of histone H3 lysine 9 (H3K9me3) and histone H3 lysine 27 (H3K27me3) in COX-2 silencing in IPF.	Lysine	111-117	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	70-74
24825348-5	2014	Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP.	Lysine	120-126	BUB1B, mitotic checkpoint serine/threonine kinase	Mus musculus	31-36
24852066-3	2014	L-lysine, L-histidine and L-tryptophan are transported by Gap1 but do not trigger signalling.	Lysine	0-8	amino acid permease GAP1	Saccharomyces cerevisiae S288C	58-62
24777605-1	2014	It is recognized that both wild-type and mutant CFTR proteins undergo ubiquitination at multiple lysines in the proteins and in one or more subcellular locations.	Lysine	97-104	CF transmembrane conductance regulator	Homo sapiens	48-52
24777605-3	2014	Mass spectrometric analysis of wild-type CFTR identified ubiquitinated lysines 68, 710, 716, 1041, and 1080.	Lysine	71-78	CF transmembrane conductance regulator	Homo sapiens	41-45
24852066-4	2014	Unlike L-histidine, L-lysine triggers Gap1 oligo-ubiquitination without substantial induction of endocytosis.	Lysine	20-28	amino acid permease GAP1	Saccharomyces cerevisiae S288C	38-42
24877974-8	2014	We also determined that the localization of p39 to lamellipodia requires myristoylation and Lys clusters within the N-terminal p10 region.	Lysine	92-95	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	Mus musculus	44-47
24691905-5	2014	By employing homologous recombination, we introduced various combinations of missense mutations (lysine to arginine) into eight acetylation sites of the endogenous p53 gene in human embryonic stem cells (hESCs).	Lysine	97-103	tumor protein p53	Homo sapiens	164-167
25070639-2	2014	In this study, using a floral stem cell model in Arabidopsis thaliana, we uncovered a role for TOPOISOMERASE1alpha (TOP1alpha) in Polycomb Group (PcG) protein-mediated histone 3 lysine 27 trimethylation (H3K27me3) at, and transcriptional repression of, the stem cell maintenance gene WUSCHEL (WUS).	Lysine	178-184	Homeodomain-like superfamily protein	Arabidopsis thaliana	284-291
25070639-2	2014	In this study, using a floral stem cell model in Arabidopsis thaliana, we uncovered a role for TOPOISOMERASE1alpha (TOP1alpha) in Polycomb Group (PcG) protein-mediated histone 3 lysine 27 trimethylation (H3K27me3) at, and transcriptional repression of, the stem cell maintenance gene WUSCHEL (WUS).	Lysine	178-184	Homeodomain-like superfamily protein	Arabidopsis thaliana	284-287
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	94-100	CREB binding protein	Homo sapiens	20-40
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	94-100	CREB binding protein	Homo sapiens	42-45
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	102-105	CREB binding protein	Homo sapiens	20-40
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	102-105	CREB binding protein	Homo sapiens	42-45
24798337-2	2014	KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(epsilon)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression.	Lysine	120-126	lysine demethylase 6A	Homo sapiens	0-5
24983957-2	2014	68Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) represents a successful novel PSMA inhibitor radiotracer which has recently demonstrated its suitability in individual first-in-man studies.	Lysine	23-26	folate hydrolase 1	Homo sapiens	50-54
24983957-2	2014	68Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) represents a successful novel PSMA inhibitor radiotracer which has recently demonstrated its suitability in individual first-in-man studies.	Lysine	23-26	folate hydrolase 1	Homo sapiens	94-98
24983957-4	2014	The simple replacement of HBED-CC by the prominent radiometal chelator DOTA was shown to dramatically reduce the in vivo imaging quality of the respective 68Ga-labelled PSMA-targeted tracer proving that HBED-CC contributes intrinsically to the PSMA binding of the Glu-urea-Lys(Ahx) pharmacophore.	Lysine	273-276	folate hydrolase 1	Homo sapiens	169-173
24798337-2	2014	KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(epsilon)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression.	Lysine	120-126	lysine demethylase 6A	Homo sapiens	7-10
24910440-5	2014	We mapped SUMOylation sites within Psmd1 and found that SUMOylation of a critical lysine immediately adjacent to the Adrm1-binding domain regulates the association of Adrm1 with Psmd1.	Lysine	82-88	proteasome 26S subunit, non-ATPase 1	Homo sapiens	35-40
24910440-5	2014	We mapped SUMOylation sites within Psmd1 and found that SUMOylation of a critical lysine immediately adjacent to the Adrm1-binding domain regulates the association of Adrm1 with Psmd1.	Lysine	82-88	proteasome 26S subunit, non-ATPase 1	Homo sapiens	178-183
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	68-71	cyclin dependent kinase 6	Homo sapiens	0-4
24971881-2	2014	We report that both small ubiquitin-like modifier (SUMO) 1 and SUMO2/3 modify ALS-linked SOD1 mutant proteins at lysine 75 in a motoneuronal cell line, the cell type affected in ALS.	Lysine	113-119	superoxide dismutase 1	Homo sapiens	89-93
24971881-3	2014	In these cells, SUMO1 modification occurred on both lysine 75 and lysine 9 of SOD1, and modification of ALS-linked SOD1 mutant proteins by SUMO3, rather than by SUMO1, significantly increased the stability of the proteins and accelerated intracellular aggregate formation.	Lysine	66-72	superoxide dismutase 1	Homo sapiens	78-82
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	68-71	cyclin dependent kinase 6	Homo sapiens	48-52
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	68-71	cyclin dependent kinase 6	Homo sapiens	48-52
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	105-108	cyclin dependent kinase 6	Homo sapiens	0-4
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	105-108	cyclin dependent kinase 6	Homo sapiens	48-52
24953629-3	2014	CDK6 is also a substrate of ubiquitin; however, CDK6 SUMOylation at Lys 216 blocks its ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.	Lysine	105-108	cyclin dependent kinase 6	Homo sapiens	48-52
24939839-8	2014	Together, the present study suggests that histone lysine methylation regulation in the LA via NMDAR-ERK-dependent signaling is involved in fear memory formation.	Lysine	50-56	mitogen-activated protein kinase 1	Homo sapiens	100-103
24742671-4	2014	Lys(449) within the intracellular C-terminal domain of the IL-22R serves as a ubiquitin acceptor site as disruption of this site by deletion or site-directed mutagenesis creates an IL-22R variant that, when expressed in cells, is degradation-resistant and not ubiquitinated.	Lysine	0-3	interleukin 22 receptor, alpha 1	Mus musculus	59-65
24742671-4	2014	Lys(449) within the intracellular C-terminal domain of the IL-22R serves as a ubiquitin acceptor site as disruption of this site by deletion or site-directed mutagenesis creates an IL-22R variant that, when expressed in cells, is degradation-resistant and not ubiquitinated.	Lysine	0-3	interleukin 22 receptor, alpha 1	Mus musculus	181-187
23912460-6	2014	Preventing the FAM83B/EGFR interaction by site-directed mutation of lysine 230 of FAM83B suppressed PLD activity and MAPK signaling.	Lysine	68-74	family with sequence similarity 83 member B	Homo sapiens	15-21
23912460-6	2014	Preventing the FAM83B/EGFR interaction by site-directed mutation of lysine 230 of FAM83B suppressed PLD activity and MAPK signaling.	Lysine	68-74	epidermal growth factor receptor	Homo sapiens	22-26
23912460-6	2014	Preventing the FAM83B/EGFR interaction by site-directed mutation of lysine 230 of FAM83B suppressed PLD activity and MAPK signaling.	Lysine	68-74	family with sequence similarity 83 member B	Homo sapiens	82-88
23912460-6	2014	Preventing the FAM83B/EGFR interaction by site-directed mutation of lysine 230 of FAM83B suppressed PLD activity and MAPK signaling.	Lysine	68-74	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	100-103
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Lysine	14-16	cholecystokinin B receptor	Homo sapiens	61-66
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	mitogen-activated protein kinase 1	Homo sapiens	115-118
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	mitogen-activated protein kinase kinase 7	Homo sapiens	175-178
24861763-2	2014	In this study, lysozyme molecularly imprinted polymers (Lys-MIPs) were successfully prepared by the entrapment method with lysozyme as the template molecule, acrylamide as the functional monomer and N,N-methylenebisacrylamide as the cross-linker.	Lysine	56-59	lysozyme	Homo sapiens	15-23
24861763-2	2014	In this study, lysozyme molecularly imprinted polymers (Lys-MIPs) were successfully prepared by the entrapment method with lysozyme as the template molecule, acrylamide as the functional monomer and N,N-methylenebisacrylamide as the cross-linker.	Lysine	56-59	lysozyme	Homo sapiens	123-131
24680668-2	2014	Dimethylation of H3K4 requires a sub-complex including WRAD (WDR5, RbBP5, Ash2L, and DPY-30), which binds to each SET1 family member forming a minimal core complex that is required for multiple lysine methylation.	Lysine	194-200	WD repeat domain 5	Homo sapiens	61-65
24680668-2	2014	Dimethylation of H3K4 requires a sub-complex including WRAD (WDR5, RbBP5, Ash2L, and DPY-30), which binds to each SET1 family member forming a minimal core complex that is required for multiple lysine methylation.	Lysine	194-200	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	67-72
24680668-2	2014	Dimethylation of H3K4 requires a sub-complex including WRAD (WDR5, RbBP5, Ash2L, and DPY-30), which binds to each SET1 family member forming a minimal core complex that is required for multiple lysine methylation.	Lysine	194-200	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	114-118
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	mitogen-activated protein kinase kinase 7	Homo sapiens	111-114
24573419-5	2014	We also show that like human apoE, recombinant NapoE is able to inhibit LDL oxidation, and it is the N-terminal domain of NapoE with lysine or arginine residues that plays a key role in inhibition of LDL oxidation.	Lysine	133-139	apolipoprotein E	Homo sapiens	29-33
25100013-2	2014	The effects of point substitutions in the DNA-binding domain of XPA (positively charged lysine residues replaced by negatively charged glutamate residues: XPA K204E, K179E, K141E, and tandem mutant K141E/K179E) on the interaction of the protein with DNA structures modeling intermediates of the damage recognition and pre-incision stages in NER were analyzed.	Lysine	88-94	XPA, DNA damage recognition and repair factor	Homo sapiens	64-67
24767850-1	2014	EZH2 is the core subunit of Polycomb repressive complex 2 catalyzing the methylation of histone H3 lysine-27 and closely involved in tumorigenesis.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24767850-5	2014	Tanshindiol treatment in Pfeiffer cells significantly decreased the tri-methylated form of histone H3 lysine-27, a substrate of EZH2, as revealed by Western blot analysis and histone methylation ELISA.	Lysine	102-108	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	128-132
24519555-8	2014	CONCLUSION: The GLP-1 receptor antagonist exendin(9-39) labelled with (125)I-BH at lysine 19 is an excellent GLP-1 radioligand that identifies human and rat GLP-1 receptors in normal and tumoural tissues.	Lysine	83-89	glucagon	Homo sapiens	16-21
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Lysine	14-16	CD4 molecule	Homo sapiens	117-120
24151879-1	2014	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	8-14	tumor protein p53	Homo sapiens	124-127
24732153-6	2014	1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB.	Lysine	65-71	vascular endothelial growth factor A	Homo sapiens	93-97
24151879-1	2014	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	69-75	tumor protein p53	Homo sapiens	124-127
24702180-5	2014	Further, the mutually exclusive interactions of MYST1 with sirtuin 1 vs AR regulate the acetylation of lysine 16 on histone H4.	Lysine	103-109	androgen receptor	Homo sapiens	72-74
24532005-11	2014	The activity of mTOR was significantly increased upon 30 min of Lys supplementation.	Lysine	64-67	mechanistic target of rapamycin kinase	Homo sapiens	16-20
24532005-12	2014	The suppressive effect of Lys on the proteolysis by the autophagic-lysosomal system was maintained partially when mTOR activity was inhibited by 100 nM rapamycin, suggesting that some regulator other than mTOR signaling, for example, Akt, might also suppress the autophagic-lysosomal system.	Lysine	26-29	mechanistic target of rapamycin kinase	Homo sapiens	114-118
24532005-12	2014	The suppressive effect of Lys on the proteolysis by the autophagic-lysosomal system was maintained partially when mTOR activity was inhibited by 100 nM rapamycin, suggesting that some regulator other than mTOR signaling, for example, Akt, might also suppress the autophagic-lysosomal system.	Lysine	26-29	AKT serine/threonine kinase 1	Homo sapiens	234-237
24532005-13	2014	From these results, we suggested that Lys suppressed the activity of the autophagic-lysosomal system in part through activation of mTOR and reduced myofibrillar protein degradation in C2C12 myotubes.	Lysine	38-41	mechanistic target of rapamycin kinase	Homo sapiens	131-135
24920333-6	2014	We found that PKL, PIF3, and BZR1 coregulate skotomorphogenesis by repressing the trimethylation of histone H3 Lys-27 (H3K27me3) on target promoters.	Lysine	111-114	phytochrome interacting factor 3	Arabidopsis thaliana	19-23
24852249-6	2014	Interestingly, an acute block of HDAC1 in ESCs leads to increased acetylation of histone H3 lysine 9 at nascent DNA together with a concomitant loss of methylation.	Lysine	92-98	histone deacetylase 1	Homo sapiens	33-38
24750273-5	2014	The Elp1 carboxy-terminal domain contains a highly conserved arginine/lysine-rich region that resembles a nuclear localization sequence (NLS).	Lysine	70-76	Elongator subunit IKI3	Saccharomyces cerevisiae S288C	4-8
24753409-5	2014	A single lysine outside Rad1"s nuclease and Rad10-binding domains is sumoylated in vivo and in vitro.	Lysine	9-15	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	24-28
24753409-5	2014	A single lysine outside Rad1"s nuclease and Rad10-binding domains is sumoylated in vivo and in vitro.	Lysine	9-15	DNA repair protein RAD10	Saccharomyces cerevisiae S288C	44-49
24556617-0	2014	Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.	Lysine	65-71	N-acetyltransferase 8 (putative)	Homo sapiens	49-55
24882095-1	2014	Neurotensin (NT) and neurotensin-related peptide (Lys(8), Asn(9), NT(8-13): LANT-6) have previously been purified from chicken intestine.	Lysine	50-53	neurotensin	Gallus gallus	21-32
24875183-7	2014	While mutation of the five identified acetylated residues weakly affected protein acetylation and stability, mutation of at least seven additional lysine residues was required to abolish acetylation and reduce protein levels of FOXA2.	Lysine	147-153	forkhead box A2	Mus musculus	228-233
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	N-acetyltransferase 8 (putative)	Homo sapiens	120-126
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	N-acetyltransferase 8 (putative)	Homo sapiens	109-113
24671417-4	2014	By analyzing the kinetics of Miro1 ubiquitination, we further demonstrate that mitochondrial damage triggers rapid (within minutes) and persistent Lys-27-type ubiquitination of Miro1 on the OMM, dependent on PINK1 and Parkin.	Lysine	147-150	ras homolog family member T1	Homo sapiens	29-34
24871947-6	2014	Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3).	Lysine	115-121	VAMP associated protein B and C	Homo sapiens	8-12
24671417-4	2014	By analyzing the kinetics of Miro1 ubiquitination, we further demonstrate that mitochondrial damage triggers rapid (within minutes) and persistent Lys-27-type ubiquitination of Miro1 on the OMM, dependent on PINK1 and Parkin.	Lysine	147-150	ras homolog family member T1	Homo sapiens	177-182
24845634-10	2014	RESULTS: Pulsed H2O2 exposure triggered the acetylation of p53 at lysine 382 (K382) and subsequent increase in its target p21(Waf1/Cip1).	Lysine	66-72	tumor protein p53	Homo sapiens	59-62
24858818-1	2014	DOT1L, the only known histone H3-lysine 79 (H3K79) methyltransferase, has been shown to be essential for the survival and proliferation of mixed-linkage leukemia (MLL) gene rearranged leukemia cells, which are often resistant to conventional chemotherapeutic agents.	Lysine	33-39	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
24793694-0	2014	A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.	Lysine	63-69	WD repeat domain 5	Homo sapiens	11-15
24733848-3	2014	The bromodomain and extraterminal (BET) proteins, Brd2, Brd3, Brd4, and BrdT, bind to acetylated lysine residues on histone or nonhistone proteins recruiting transcriptional regulators and thus activating or repressing gene transcription.	Lysine	97-103	bromodomain containing 4	Homo sapiens	62-66
24662292-7	2014	The Pex10p Pex12p complex catalyzes monoubiquitination of Pex5p at one of multiple lysine residues in vitro, following the dissociation of Pex5p from Pex14p and the PTS1 cargo.	Lysine	83-89	peroxisomal biogenesis factor 10	Homo sapiens	4-9
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Lysine	31-37	peroxisomal biogenesis factor 10	Homo sapiens	84-90
24886859-0	2014	Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.	Lysine	67-73	interleukin 1 beta	Homo sapiens	91-108
24886859-3	2014	In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.	Lysine	55-61	interleukin 1 beta	Homo sapiens	86-103
24886859-3	2014	In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.	Lysine	55-61	interleukin 1 beta	Homo sapiens	105-113
24816405-4	2014	IL-22 acted on cancer cells to promote activation of the transcription factor STAT3 and expression of the histone 3 lysine 79 (H3K79) methytransferase DOT1L.	Lysine	116-122	DOT1 like histone lysine methyltransferase	Homo sapiens	151-156
24725156-0	2014	Charge clamps of lysines and hydrogen bonds play key roles in the mechanism to fix helix 12 in the agonist and antagonist positions of estrogen receptor alpha: intramolecular interactions studied by the ab initio fragment molecular orbital method.	Lysine	17-24	estrogen receptor 1	Homo sapiens	135-158
24633296-5	2014	We describe here an MHC class II binding peptide from the tumor protein p53, which possesses an acetylated lysine at position 120 (p53110-124/AcK120) that is effective in eliciting CD4(+) T cell responses specific for the acetylated peptide.	Lysine	107-113	tumor protein p53	Homo sapiens	72-75
24821572-4	2014	Smurf1 physically interacts with Nedd8 and Ubc12, forms a Nedd8-thioester intermediate, and then catalyses its own neddylation on multiple lysine residues.	Lysine	139-145	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	0-6
24726732-2	2014	Histone methyltransferase EZH2 and histone demethylase JMJD3 (KDM6B) modulate levels of histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	26-30
23770847-3	2014	API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-kappaB activation.	Lysine	46-52	nuclear factor kappa B subunit 1	Homo sapiens	90-99
24798477-2	2014	MATERIALS AND METHODS: Nanobubbles carrying AR siRNA were prepared using poly-L-lysine and electrostatic adsorption methods.	Lysine	73-86	androgen receptor	Homo sapiens	44-46
24633296-5	2014	We describe here an MHC class II binding peptide from the tumor protein p53, which possesses an acetylated lysine at position 120 (p53110-124/AcK120) that is effective in eliciting CD4(+) T cell responses specific for the acetylated peptide.	Lysine	107-113	CD4 molecule	Homo sapiens	181-184
24528089-6	2014	By employing the quantitative chromatin immunoprecipitation assay in detecting specific histone modifications in senescence-related genes including p53 and p16, it was demonstrated that the mRNA expression of p53 was associated with increased H4 acetylation in replicative senescence and increased H4 acetylation and trimethylation of histone H3 at lysine 4 (H3K4me3) in premature senescence.	Lysine	349-355	tumor protein p53	Homo sapiens	148-151
24269836-2	2014	Lysine acetylation, in combination with other PTMs, directs the outcomes as well as the activation levels of important signal transduction pathways such as the nuclear factor (NF)-kappaB pathway.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	160-186
24561908-1	2014	In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) was identified as a histone demethylase that specifically targets di- and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3).	Lysine	180-186	lysine demethylase 6A	Homo sapiens	80-83
24588869-5	2014	Here we present evidence that the histone H3 lysine 9 (H3K9) methyltransferase suppressor of variegation 3-9 homolog 1 (Suv39 h1) transcriptionally represses BZLF1 in B95-8 cells by promoting repressive trimethylation at H3K9 (H3K9me3).	Lysine	45-51	SUV39H1 histone lysine methyltransferase	Homo sapiens	120-128
24528089-6	2014	By employing the quantitative chromatin immunoprecipitation assay in detecting specific histone modifications in senescence-related genes including p53 and p16, it was demonstrated that the mRNA expression of p53 was associated with increased H4 acetylation in replicative senescence and increased H4 acetylation and trimethylation of histone H3 at lysine 4 (H3K4me3) in premature senescence.	Lysine	349-355	tumor protein p53	Homo sapiens	209-212
24769691-2	2014	Druggability estimates and pocket opening analyses indicated binding regions of cyclin T1 residues, Phe 146 and Lys 6, as starting points for the design of small molecules with the potential to inhibit the CDK9/cyclin T1 association.	Lysine	112-115	cyclin dependent kinase 9	Homo sapiens	206-210
24268865-0	2014	Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection.	Lysine	13-19	albumin	Homo sapiens	49-62
24268865-5	2014	Fourier transform infrared spectroscopy showed that BSA is in its native state even in the presence of ArgHCl, LysHCl, and NaCl at high protein concentrations.	Lysine	111-117	albumin	Homo sapiens	52-55
24769691-2	2014	Druggability estimates and pocket opening analyses indicated binding regions of cyclin T1 residues, Phe 146 and Lys 6, as starting points for the design of small molecules with the potential to inhibit the CDK9/cyclin T1 association.	Lysine	112-115	cyclin T1	Homo sapiens	211-220
24526064-4	2014	Enhancer of zeste homolog 2 (EZH2), catalytic core subunit of PRC2, epigenetically silences several tumor-suppressor genes by catalyzing the trimethylation of histone H3 at lysine 27, which serves as a docking site for DNA methyltransferases and histone deacetylases.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
24435446-1	2014	The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2.	Lysine	100-107	bromodomain containing 4	Homo sapiens	75-79
24435446-1	2014	The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2.	Lysine	100-107	BCL2 apoptosis regulator	Homo sapiens	195-199
24526064-4	2014	Enhancer of zeste homolog 2 (EZH2), catalytic core subunit of PRC2, epigenetically silences several tumor-suppressor genes by catalyzing the trimethylation of histone H3 at lysine 27, which serves as a docking site for DNA methyltransferases and histone deacetylases.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
24442343-3	2014	We have previously identified histone H3 lysine 4 trimethylation (H3K4me3) as an activator of myometrial PR-A expression at labour.	Lysine	41-47	S100 calcium binding protein A6	Homo sapiens	105-109
23686307-1	2014	Acetylation of the RelA subunit of NF-kappaB at lysine-310 regulates the transcriptional activation of NF-kappaB target genes and contributes to maintaining constitutively active NF-kappaB in tumors.	Lysine	48-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-44
24529480-2	2014	The localisation of LYRIC/AEG-1 appears crucial to its function and is regulated by three lysine-rich nuclear localisation signal regions, one of which was previously demonstrated to be modified by ubiquitin.	Lysine	90-96	metadherin	Homo sapiens	20-25
24529480-2	2014	The localisation of LYRIC/AEG-1 appears crucial to its function and is regulated by three lysine-rich nuclear localisation signal regions, one of which was previously demonstrated to be modified by ubiquitin.	Lysine	90-96	metadherin	Homo sapiens	26-31
23686307-1	2014	Acetylation of the RelA subunit of NF-kappaB at lysine-310 regulates the transcriptional activation of NF-kappaB target genes and contributes to maintaining constitutively active NF-kappaB in tumors.	Lysine	48-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
23686307-1	2014	Acetylation of the RelA subunit of NF-kappaB at lysine-310 regulates the transcriptional activation of NF-kappaB target genes and contributes to maintaining constitutively active NF-kappaB in tumors.	Lysine	48-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
24464532-4	2014	METHODS: The nonapeptide BZH3 representing the GRPR binding part was combined with the urea-based PSMA inhibitor Glu-urea-Lys(Ahx)-HBED-CC.	Lysine	122-125	gastrin releasing peptide receptor	Homo sapiens	47-51
24464532-4	2014	METHODS: The nonapeptide BZH3 representing the GRPR binding part was combined with the urea-based PSMA inhibitor Glu-urea-Lys(Ahx)-HBED-CC.	Lysine	122-125	folate hydrolase 1	Homo sapiens	98-102
24775912-8	2014	RESULTS: Grb2 can be SUMOylated by SUMO1 at lysine 56 (K56), which is located in the linker region between the N-terminal SH3 domain and the SH2 domain.	Lysine	44-50	small ubiquitin-like modifier 1	Mus musculus	35-40
24239489-5	2014	STUDY DESIGN: An experimental study investigating the phosphorylation profile of an important Cl-regulatory protein Na+-K+-Cl- cotransporter 1 (NKCC1) and its regulatory-kinase WNK1 (kinase with-no-lysine).	Lysine	198-204	WNK lysine deficient protein kinase 1	Rattus norvegicus	177-181
24567338-9	2014	Thus, RetGC1 activation by GCAP1 involves establishing a tight complex through the binding patch with an additional activation step involving Met-26, Lys-85, and Trp-94.	Lysine	150-153	guanylate cyclase activator 1A	Homo sapiens	27-32
24708346-1	2014	This work aims at studying the interaction between human serum albumin and different generations of dendrigraft poly-L-lysine (DGL) in physiological conditions.	Lysine	112-125	albumin	Homo sapiens	57-70
24485852-1	2014	The Drosophila melanogaster histone lysine methyltransferase (HKMT) Eggless (Egg/dSETDB1) catalyzes methylation of Histone H3 lysine 9 (H3K9), a signature of repressive heterochromatin.	Lysine	36-42	eggless	Drosophila melanogaster	68-75
24485852-1	2014	The Drosophila melanogaster histone lysine methyltransferase (HKMT) Eggless (Egg/dSETDB1) catalyzes methylation of Histone H3 lysine 9 (H3K9), a signature of repressive heterochromatin.	Lysine	36-42	eggless	Drosophila melanogaster	81-88
23933118-8	2014	Thus, menin by forming a subunit of the mixed lineage leukemia (MLL) complexes that trimethylate histone H3 at lysine 4 (H3K4), facilitates activation of transcriptional activity in target genes such as cyclin-dependent kinase (CDK) inhibitors; and by interacting with the suppressor of variegation 3-9 homolog family protein (SUV39H1) to mediate H3K methylation, thereby silencing transcriptional activity of target genes.	Lysine	111-117	menin 1	Homo sapiens	6-11
24684440-2	2014	A product of COX-2 activation, levuglandin (LG) quickly forms covalent bonds with nearby primary amines, such as those in lysine, which leads to LG-protein adducts.	Lysine	122-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-18
24706898-3	2014	MEX3C colocalizes with RIG-I in the stress granules of virally infected cells, and its overexpression causes the lysine-63-linked ubiquitination of RIG-I and activates IFN-beta promoter.	Lysine	113-119	mex3 RNA binding family member C	Mus musculus	0-5
24134677-2	2014	We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes.	Lysine	51-57	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	147-152
24617810-3	2014	NMR spectroscopy and replica-exchange molecular dynamics indicate that introduction of a phosphate group or phosphomimetic at position 26 diminishes Abeta"s propensity to form a beta-hairpin, rigidifies the region around the modification site, and interferes with formation of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.	Lysine	336-342	amyloid beta precursor protein	Homo sapiens	149-154
24134677-2	2014	We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes.	Lysine	51-57	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	226-231
24336050-3	2014	Furthermore, we identified two lysine sites at 184 and 185 that appear to be targeted for ubiquitination by MKRN1.	Lysine	31-37	makorin, ring finger protein, 1	Mus musculus	108-113
24115157-4	2014	The levels of methylation of lysines 4 and 36 and acetylation of histone H3, markers for active chromatin, were also reduced at the Bsp gene in these cells.	Lysine	29-36	integrin binding sialoprotein	Homo sapiens	132-135
24563539-6	2014	EPZ-6438 selectively inhibits intracellular lysine 27 of histone H3 (H3K27) methylation in a concentration- and time-dependent manner in both EZH2 wild-type and mutant lymphoma cells.	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	142-146
24508213-3	2014	METHODS: The PSMA/GRPr dual targeting ligand precursor [DUPA-6-Ahx-K-5-Ava-BBN(7-14)NH2], was synthesized by solid-phase and manual peptide synthesis, after which NODAGA was added via manual conjugation to the epsilon-amine of lysine (K).	Lysine	227-233	folate hydrolase 1	Homo sapiens	13-17
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	mechanistic target of rapamycin kinase	Homo sapiens	83-87
24474444-10	2014	Total mTOR protein expression was greater (P &lt; 0.05) with Lys alone and also Lys&amp;Met.	Lysine	61-64	mechanistic target of rapamycin kinase	Homo sapiens	6-10
24474444-0	2014	Ratio of lysine to methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells.	Lysine	9-15	casein kappa	Bos taurus	69-81
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	59-65	casein kappa	Bos taurus	102-114
24474444-10	2014	Total mTOR protein expression was greater (P &lt; 0.05) with Lys alone and also Lys&amp;Met.	Lysine	80-83	mechanistic target of rapamycin kinase	Homo sapiens	6-10
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	59-65	mechanistic target of rapamycin kinase	Homo sapiens	209-238
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	82-85	casein kappa	Bos taurus	102-114
24639513-0	2014	Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression.	Lysine	11-17	Tat interactive protein 60kDa	Drosophila melanogaster	87-92
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	82-85	mechanistic target of rapamycin kinase	Homo sapiens	209-238
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	lactalbumin alpha	Homo sapiens	59-64
24550385-10	2014	We found that ITCH mediates Lys-63-linked polyubiquitination of WWOX, leading to its nuclear localization and increased cell death.	Lysine	28-31	itchy E3 ubiquitin protein ligase	Homo sapiens	14-18
24550385-10	2014	We found that ITCH mediates Lys-63-linked polyubiquitination of WWOX, leading to its nuclear localization and increased cell death.	Lysine	28-31	WW domain containing oxidoreductase	Homo sapiens	64-68
24667498-5	2014	We found that p53 indeed exists as a hydroxylated protein in vivo and that the hydroxylation occurs mainly on lysine 382 of p53.	Lysine	110-116	tumor protein p53	Homo sapiens	14-17
24449821-8	2014	Plasminogen directly binds to VWF and its A1 domain in a lysine-dependent manner, as determined by enzyme-linked immunosorbent assay.	Lysine	57-63	von Willebrand factor	Homo sapiens	30-33
24667498-5	2014	We found that p53 indeed exists as a hydroxylated protein in vivo and that the hydroxylation occurs mainly on lysine 382 of p53.	Lysine	110-116	tumor protein p53	Homo sapiens	124-127
24637349-6	2014	Sequencing of the candidate genes showed a heterozygous c.69 G T change in the heat shock transcription factor 4 (HSF4) gene, which resulted in the substitution of a lysine with an asparagine (p. K23N).	Lysine	166-172	heat shock transcription factor 4	Homo sapiens	79-112
24616510-2	2014	Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its other monoacetylated binding partners.	Lysine	82-88	CREB binding protein	Homo sapiens	44-47
24616512-4	2014	A point mutation in an evolutionarily conserved lysine-rich domain encoded by the alternatively spliced Zfp318 exon 10 abolished IgD expression on marginal zone B cells, decreased IgD on follicular B cells, and increased IgM, but only slightly decreased the percentage of B cells and did not decrease expression of other maturation markers CD21, CD23, or CD62L.	Lysine	48-54	selectin, lymphocyte	Mus musculus	355-360
24492606-1	2014	EZH2, a core component of polycomb repressive complex 2 (PRC2), plays a role in transcriptional repression through histone H3 Lys-27 trimethylation and is involved in various biological processes, including hematopoiesis.	Lysine	126-129	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24304166-1	2014	EZH2/PRC2 catalyzes transcriptionally repressive methylation at lysine 27 of histone H3 and has been associated with numerous cancer types.	Lysine	64-70	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24647965-4	2014	We observe that Parkin efficiently ubiquitylates Miro1 at highly conserved lysine residues, 153, 230, 235, 330 and 572, upon phosphorylation by PINK1.	Lysine	75-81	ras homolog family member T1	Homo sapiens	49-54
24637349-6	2014	Sequencing of the candidate genes showed a heterozygous c.69 G T change in the heat shock transcription factor 4 (HSF4) gene, which resulted in the substitution of a lysine with an asparagine (p. K23N).	Lysine	166-172	heat shock transcription factor 4	Homo sapiens	114-118
24626927-3	2014	The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1.	Lysine	58-64	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	106-133
24491801-4	2014	Here, we show that in breast cancer cells, the histone H3 lysine 27 (H3K27) demethylase UTX (also known as KDM6A) positively regulates gene expression programs associated with cell proliferation and invasion.	Lysine	58-64	lysine demethylase 6A	Homo sapiens	88-91
24491801-4	2014	Here, we show that in breast cancer cells, the histone H3 lysine 27 (H3K27) demethylase UTX (also known as KDM6A) positively regulates gene expression programs associated with cell proliferation and invasion.	Lysine	58-64	lysine demethylase 6A	Homo sapiens	107-112
24482232-2	2014	We recently showed that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is necessary for tumorigenic and metastatic capabilities of KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells.	Lysine	39-45	lysine (K)-specific demethylase 2A	Mus musculus	69-74
24626927-3	2014	The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1.	Lysine	58-64	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	135-140
24626927-3	2014	The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1.	Lysine	58-64	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	184-189
24451372-4	2014	Among a stretch of ~10 amino acids in the NH2 terminus between the chromodomain and MORF4-related gene (MRG) domain within MORF4L1, Lys-148 is normally acetylated.	Lysine	132-135	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	84-102
24482232-2	2014	We recently showed that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is necessary for tumorigenic and metastatic capabilities of KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells.	Lysine	39-45	lysine (K)-specific demethylase 2A	Mus musculus	88-94
24482232-2	2014	We recently showed that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is necessary for tumorigenic and metastatic capabilities of KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells.	Lysine	39-45	lysine (K)-specific demethylase 2A	Mus musculus	99-105
24482232-2	2014	We recently showed that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is necessary for tumorigenic and metastatic capabilities of KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells.	Lysine	39-45	lysine (K)-specific demethylase 2A	Mus musculus	167-172
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Lysine	142-148	amino acid permease GAP1	Saccharomyces cerevisiae S288C	46-50
24451372-4	2014	Among a stretch of ~10 amino acids in the NH2 terminus between the chromodomain and MORF4-related gene (MRG) domain within MORF4L1, Lys-148 is normally acetylated.	Lysine	132-135	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	104-107
24451372-7	2014	HDAC2, a deacetylase, interacts with and keeps MORF4L1 in a deacetylation status at Lys(148) that triggers MORF4L1 self-assembly.	Lysine	84-87	histone deacetylase 2	Homo sapiens	0-5
24231430-0	2014	Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.	Lysine	34-37	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	78-83
24231430-0	2014	Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.	Lysine	34-37	ATP binding cassette subfamily C member 1	Homo sapiens	84-89
24231430-0	2014	Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.	Lysine	47-50	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
24231430-0	2014	Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.	Lysine	47-50	ATP binding cassette subfamily C member 1	Homo sapiens	84-89
24231430-2	2014	We previously showed that Ala substitutions of Lys(513) and Lys(516) in the cytoplasmic loop (CL5) connecting transmembrane helix 9 (TM9) to TM10 cause misfolding of MRP1, abrogating its expression at the plasma membrane in transfected human embryonic kidney (HEK) cells.	Lysine	47-50	ATP binding cassette subfamily B member 1	Homo sapiens	166-170
24231430-10	2014	Thus, despite their close proximity to one another in CL5, Lys(513) and Lys(516) participate in different interdomain interactions crucial for the proper folding and assembly of MRP1.	Lysine	59-62	ATP binding cassette subfamily B member 1	Homo sapiens	178-182
24231430-10	2014	Thus, despite their close proximity to one another in CL5, Lys(513) and Lys(516) participate in different interdomain interactions crucial for the proper folding and assembly of MRP1.	Lysine	72-75	ATP binding cassette subfamily B member 1	Homo sapiens	178-182
24111946-0	2014	Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.	Lysine	28-34	histone deacetylase 1	Homo sapiens	166-173
24513187-7	2014	Both global acetylation of histone H3 and specific acetylation at lysine 18 (H3AcK18) were lowered by BF1 treatment.	Lysine	66-72	forkhead box G1	Homo sapiens	102-105
23943221-2	2014	Trimethylation of histone 3 lysine 9 (H3K9me3), a repressed transcription mark, is mainly regulated by the histone lysine N-methyltransferases (HKMTs), SUV39H1 and SETDB1.	Lysine	28-34	SUV39H1 histone lysine methyltransferase	Homo sapiens	152-159
24344202-7	2014	Mass spectrometry and mutagenesis analyses indicated that in SIRT3-deficient cells OPA1 was acetylated at lysine 926 and 931 residues.	Lysine	106-112	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	83-87
24188180-3	2014	Here, we report that the MeCP2 protein can be modified by covalent linkage to small ubiquitin-like modifier (SUMO) and SUMOylation at lysine 223 is necessary for its transcriptional repression function.	Lysine	134-140	methyl-CpG binding protein 2	Homo sapiens	25-30
24379439-3	2014	Intact, activated erbB3 phosphorylates tyrosine sites in an exogenous peptide substrate, and this activity is abolished by mutagenesis of lysine 723 in the catalytic domain.	Lysine	138-144	receptor tyrosine-protein kinase erbB-3	Cricetulus griseus	18-23
23943221-2	2014	Trimethylation of histone 3 lysine 9 (H3K9me3), a repressed transcription mark, is mainly regulated by the histone lysine N-methyltransferases (HKMTs), SUV39H1 and SETDB1.	Lysine	28-34	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	164-170
24726141-4	2014	We confirmed lysine 528 to be a target of SMYD2-dependent PARP1 methylation by LC-MS/MS and Edman Degradation analyses.	Lysine	13-19	poly(ADP-ribose) polymerase 1	Homo sapiens	58-63
24303925-7	2014	Our research indicated that blue light irradiation caused cleavage throughout the A2E molecule closest to the pyridinium ring, and attached to the fibronectin peptide preferentially at lysine and arginine residues.	Lysine	185-191	fibronectin 1	Homo sapiens	147-158
24369422-2	2014	Here, we show that L3MBTL2 is modified by SUMO2/3 at lysine residues 675 and 700 close to the C-terminus.	Lysine	53-59	L3MBTL histone methyl-lysine binding protein 2	Homo sapiens	19-26
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	24-27	tumor protein p53	Homo sapiens	145-148
24375404-5	2014	We found that MYBBP1A has two regions that directly bind to lysine residues of the p53 C-terminal regulatory domain.	Lysine	60-66	MYB binding protein 1a	Homo sapiens	14-21
24375404-5	2014	We found that MYBBP1A has two regions that directly bind to lysine residues of the p53 C-terminal regulatory domain.	Lysine	60-66	tumor protein p53	Homo sapiens	83-86
24123378-1	2014	The methyltransferase, Enhancer of Zeste homology 2 (EZH2), trimethylates histone 3 lysine 27 (H3K27me3) on chromatin and this repressive mark is removed by lysine demethylase 6A (KDM6A).	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	23-51
24123378-1	2014	The methyltransferase, Enhancer of Zeste homology 2 (EZH2), trimethylates histone 3 lysine 27 (H3K27me3) on chromatin and this repressive mark is removed by lysine demethylase 6A (KDM6A).	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	53-57
24123378-1	2014	The methyltransferase, Enhancer of Zeste homology 2 (EZH2), trimethylates histone 3 lysine 27 (H3K27me3) on chromatin and this repressive mark is removed by lysine demethylase 6A (KDM6A).	Lysine	84-90	lysine demethylase 6A	Homo sapiens	157-178
24123378-1	2014	The methyltransferase, Enhancer of Zeste homology 2 (EZH2), trimethylates histone 3 lysine 27 (H3K27me3) on chromatin and this repressive mark is removed by lysine demethylase 6A (KDM6A).	Lysine	84-90	lysine demethylase 6A	Homo sapiens	180-185
24403071-3	2014	Here we report that Otub1 is monoubiquitinated by UbcH5 in cells and in vitro, primarily at the lysine 59 and 109 residues.	Lysine	96-102	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	20-25
24403071-5	2014	The lysine-free Otub1 mutant (Otub1(K0)) fails to be monoubiquitinated and is unable to suppress the Ub-conjugating activity of UbcH5 in vitro and the MDM2-mediated p53 ubiquitination in cells.	Lysine	4-10	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	16-21
24486017-3	2014	Here, we report that lysine acetylation of PDHA1 and PDP1 is common in epidermal growth factor (EGF)-stimulated cells and diverse human cancer cells.	Lysine	21-27	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	53-57
24403071-5	2014	The lysine-free Otub1 mutant (Otub1(K0)) fails to be monoubiquitinated and is unable to suppress the Ub-conjugating activity of UbcH5 in vitro and the MDM2-mediated p53 ubiquitination in cells.	Lysine	4-10	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	30-35
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	14-17	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	44-49
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	14-17	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	96-101
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	14-17	tumor protein p53	Homo sapiens	145-148
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	24-27	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	44-49
24403071-8	2014	Adding either Lys-59 or Lys-109 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabilize and activate p53.	Lysine	24-27	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	96-101
24486019-5	2014	This posttranslational modification takes place at an invariant lysine within the eRF1 NIKS motif and is required for optimal translational termination efficiency.	Lysine	64-70	eukaryotic translation termination factor 1	Homo sapiens	82-86
24503539-1	2014	Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions.	Lysine	106-112	sirtuin 3	Homo sapiens	0-9
24525728-4	2014	Mutations in Noxa within the BH3 domain, the carboxyl terminus mitochondrial targeting domain, or of ubiquitinated lysines not only change the localization and stability of Noxa itself but also affect the mitochondrial localization and phosphorylation/ubiquitination status of MCL-1 and consequently modulate sensitivity to ABT-737.	Lysine	115-122	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	173-177
24521543-3	2014	Complementation in ESCs shows that WDR5 F266A mutant is unable to accumulate on chromatin, and is defective in gene activation, maintenance of histone H3 lysine 4 trimethylation, and ESC self renewal.	Lysine	154-160	WD repeat domain 5	Homo sapiens	35-39
24362262-0	2014	Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal.	Lysine	57-63	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
24362262-3	2014	Here, we report that acetylation at lysine 254 (K254) increases GAPDH activity in response to glucose.	Lysine	36-42	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	64-69
24586180-2	2014	In a cell culture screen, we identified that Lysine at position 142 was a K63-linked Ubiquitin acceptor site for TAK1, required for signalling.	Lysine	45-51	TGF-beta activated kinase 1	Drosophila melanogaster	113-117
24586180-3	2014	Moreover, Lysine at position 156 functioned as a K48-linked Ubiquitin acceptor site, also necessary for TAK1 activity.	Lysine	10-16	TGF-beta activated kinase 1	Drosophila melanogaster	104-108
24338010-4	2014	Comparative structural analysis reveals a tripartite lysine claw in NPP1 that stabilizes the terminal phosphate of ATP, whereas the corresponding region of NPP4 contains features that hinder this binding orientation, thereby inhibiting ATP hydrolysis.	Lysine	53-59	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	68-72
24503539-1	2014	Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions.	Lysine	106-112	sirtuin 3	Homo sapiens	11-16
24362326-1	2014	EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3.	Lysine	145-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24361270-4	2014	Here, we report high-resolution crystal structures of the bromodomain-PHD tandem module of human transcriptional coactivator CBP bound to lysine-acetylated histone H4 peptides.	Lysine	138-144	CREB binding protein	Homo sapiens	125-128
24390408-4	2014	The alkylated peptides obtained after enzymatic hydrolysis of human SA modified with the different PAHDE were principally PAHDE-His-Pro, PAHDE-His-Pro-Tyr and PAHDE-Lys.	Lysine	165-168	albumin	Homo sapiens	68-70
24418777-2	2014	Building upon the construct of DOTA-Ahx-(D-Lys(6)-GnRH1) we previously reported, an aromatic amino acid of D-Phe was inserted either between the DOTA and Ahx or between the Ahx and D-Lys(6) to generate new DOTA-D-Phe-Ahx-(D-Lys(6)-GnRH) or DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) peptides.	Lysine	42-46	nuclear receptor subfamily 0 group B member 1	Homo sapiens	36-39
24418777-4	2014	The tumor targeting and pharmacokinetic properties of (111)In-DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) was determined in MDA-MB-231 human breast cancer-xenografted nude mice.	Lysine	79-83	nuclear receptor subfamily 0 group B member 1	Homo sapiens	67-70
24418777-5	2014	Compared to (111)In-DOTA-Ahx-(D-Lys(6)-GnRH1), (111)In-DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) exhibited comparable tumor uptake with faster renal and liver clearance.	Lysine	72-76	nuclear receptor subfamily 0 group B member 1	Homo sapiens	60-63
24234436-2	2014	Herein, we found that upstream binding factor (UBF) interacts with ESET, a histone H3K9 methyltransferase and is trimethylated at Lys (K) 232/254 by ESET.	Lysine	130-133	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	67-71
24308962-2	2014	In this report we showed that TRIM50 is a target of HDAC6 with Lys-372 as a critical residue for acetylation.	Lysine	63-66	histone deacetylase 6	Homo sapiens	52-57
24401370-5	2014	The Frizzled cysteine-rich domain (CRD) and invariant second intracellular loop lysine are crucial for PLR-1 downregulation.	Lysine	80-86	putative E3 ubiquitin-protein ligase plr-1	Caenorhabditis elegans	103-108
24401370-9	2014	We propose that PLR-1 downregulates Wnt receptor surface levels via lysine ubiquitylation of Frizzled to coordinate spatial and temporal responses to Wnts during neuronal development.	Lysine	68-74	putative E3 ubiquitin-protein ligase plr-1	Caenorhabditis elegans	16-21
23873758-7	2014	ChIP reChIP assays revealed that SirT1 and Set7/9 form a protein complex on the COL2A1 promoter region of 3D-cultured chondrocytes, which also demonstrated elevated trimethylated lysine 4 on histone 3 (3MeH3K4), a hallmark of Set7/9 methyltransferase activity.	Lysine	179-185	collagen type II alpha 1 chain	Homo sapiens	80-86
24234436-2	2014	Herein, we found that upstream binding factor (UBF) interacts with ESET, a histone H3K9 methyltransferase and is trimethylated at Lys (K) 232/254 by ESET.	Lysine	130-133	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	149-153
24318875-2	2014	We show here that JMJD1C, a histone 3 lysine 9 (H3K9) demethylase expressed in hESCs, directly interacts with this circuitry.	Lysine	38-44	jumonji domain containing 1C	Homo sapiens	18-24
24445350-3	2014	Lysine acetylation and cytosine methylation inhibitors idiosyncratically tune the transcriptome and affect expression of key modulators of angiogenesis such as VEGF and eNOS.	Lysine	0-6	vascular endothelial growth factor A	Homo sapiens	160-164
24489825-4	2014	Likewise, Nef induced CXCR4 degradation was critically dependent on the three lysines in the C-terminal -SSLKILSKGK- motif.	Lysine	78-85	S100 calcium binding protein B	Homo sapiens	10-13
24325674-11	2014	Overall, disruption of the structural and functional integrity of apoE by oxidative modification of essential lysine residues by acrolein is expected to affect its role in maintaining plasma cholesterol homeostasis and lead to dysregulation in lipid metabolism.	Lysine	110-116	apolipoprotein E	Rattus norvegicus	66-70
23318417-7	2014	AR activation recruits the polycomb group protein EZH2, which subsequently catalyzes histone H3 lysine 27 tri-methylation around the NOV promoter, thus leading to repressive chromatin remodeling and epigenetic silencing.	Lysine	96-102	androgen receptor	Homo sapiens	0-2
23318417-7	2014	AR activation recruits the polycomb group protein EZH2, which subsequently catalyzes histone H3 lysine 27 tri-methylation around the NOV promoter, thus leading to repressive chromatin remodeling and epigenetic silencing.	Lysine	96-102	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	50-54
24325674-5	2014	In initial studies, acrolein-modified apoE was identified by immunoprecipitation using an acrolein-lysine specific antibody in the plasma of 10-week old male rats that were exposed to filtered air (FA) or low doses of environmental tobacco smoke (ETS).	Lysine	99-105	apolipoprotein E	Rattus norvegicus	38-42
24333447-4	2014	Here we show that the sensitivity of both COX-1 and COX-2 to EP1 is altered upon modification of one lysine residue.	Lysine	101-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
24297181-8	2014	The Glu(403)-Lys(118) salt bridge in C-domain ACE was shown to stabilize the hinge-bending region and reduce chloride affinity by constraining the chloride 2 pocket.	Lysine	13-16	angiotensin I converting enzyme	Homo sapiens	46-49
24454848-4	2014	Most (24 of 33) ApoE mutant proteins registered to date with Online Mendelian Inheritance in Man, such as ApoE2 and ApoE4, involve lysine and arginine mutations.	Lysine	131-137	apolipoprotein E	Homo sapiens	16-20
24454848-4	2014	Most (24 of 33) ApoE mutant proteins registered to date with Online Mendelian Inheritance in Man, such as ApoE2 and ApoE4, involve lysine and arginine mutations.	Lysine	131-137	apolipoprotein E	Homo sapiens	106-111
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Lysine	20-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24399296-7	2014	TRAF6 recruited PS1 to the TbetaRI complex and promoted lysine-63-linked polyubiquitination of PS1, which activated PS1.	Lysine	56-62	TNF receptor-associated factor 6	Mus musculus	0-5
24076356-8	2014	When comparing the myoglobin sequence from TA with the Ovis aries myoglobin sequence, variations were observed at codons 21 (GGT GAT) and 78 (GAA AAG), and these variations lead to changes in the corresponding amino acids, i.e., Gly Asp and Glu Lys, respectively.	Lysine	245-248	myoglobin	Pantholops hodgsonii	19-28
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	interferon alpha 1	Homo sapiens	283-292
24294910-7	2014	Cyt c lysine residues were modified with lactose at a lactose-to-protein molar ratio of 3.7 +- 0.9 using mono(lactosylamido)-mono(succinimidyl) suberate linker chemistry.	Lysine	6-12	cytochrome c, somatic	Homo sapiens	0-5
24309115-4	2014	We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation.	Lysine	17-23	nuclear mitotic apparatus protein 1	Homo sapiens	52-56
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	interferon alpha 1	Homo sapiens	283-292
24399297-7	2014	In contrast, expression of wild-type USP15, but not its catalytically inactive mutant, reduced the Lys(48)-linked ubiquitylation of TRIM25, leading to its stabilization.	Lysine	99-102	ubiquitin specific peptidase 15	Homo sapiens	37-42
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	FUS RNA binding protein	Homo sapiens	138-141
24621507-3	2014	Conversely, Tip60 activates p53 through direct association on target promoters as well as acetylation of p53 at lysine 120 (K120).	Lysine	112-118	tumor protein p53	Homo sapiens	105-108
24385627-4	2014	This modification leads to the recruitment of the histone deacetylase Hst2p that subsequently removes an acetyl group from histone H4 lysine 16, freeing the H4 tail to interact with the surface of neighboring nucleosomes and promoting fiber condensation.	Lysine	134-140	histone deacetylase HST2	Saccharomyces cerevisiae S288C	70-75
24716982-1	2014	Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues on protein substrates.	Lysine	143-149	lysyl oxidase like 2	Homo sapiens	0-20
24716982-1	2014	Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues on protein substrates.	Lysine	143-149	lysyl oxidase like 2	Homo sapiens	22-27
25483963-9	2014	PELI3 was found to be ubiquitinated upon LPS stimulation and point mutation of PELI3-lysine residue 316 (Lys316Arg) attenuated Torin2-dependent degradation of PELI3.	Lysine	85-91	pellino 3	Mus musculus	0-5
25483963-9	2014	PELI3 was found to be ubiquitinated upon LPS stimulation and point mutation of PELI3-lysine residue 316 (Lys316Arg) attenuated Torin2-dependent degradation of PELI3.	Lysine	85-91	pellino 3	Mus musculus	79-84
25483963-9	2014	PELI3 was found to be ubiquitinated upon LPS stimulation and point mutation of PELI3-lysine residue 316 (Lys316Arg) attenuated Torin2-dependent degradation of PELI3.	Lysine	85-91	pellino 3	Mus musculus	79-84
25520914-1	2014	Enhancer of Zeste homlog 2 (EZH2) is a catalytic subunit of epigenetic regulator Polycomb repressive complex 2 (PRC2), which trimethylates Lys 27 of histone H3, leading to silencing of the target genes that are involved in a variety of biological processes including tumor progression and stem cell maintenance.	Lysine	139-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-26
25520914-1	2014	Enhancer of Zeste homlog 2 (EZH2) is a catalytic subunit of epigenetic regulator Polycomb repressive complex 2 (PRC2), which trimethylates Lys 27 of histone H3, leading to silencing of the target genes that are involved in a variety of biological processes including tumor progression and stem cell maintenance.	Lysine	139-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
25535899-3	2014	We showed that the histone methyltransferase EZH2, which catalyzes methylation of histone H3 lysine 27 (H3K27), was upregulated in colon cancers in The Cancer Genome Atlas (TCGA) database.	Lysine	93-99	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-49
24675890-5	2014	This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression.	Lysine	152-158	snail family transcriptional repressor 1	Homo sapiens	30-35
24165275-4	2014	Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus.	Lysine	179-185	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	127-131
24165275-4	2014	Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus.	Lysine	179-185	homeobox D cluster	Homo sapiens	211-215
24761888-6	2014	Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively.	Lysine	108-111	tumor protein p53	Homo sapiens	54-57
24761888-6	2014	Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively.	Lysine	108-111	glutathione S-transferase mu 1	Homo sapiens	213-218
24161695-5	2014	Induction of the SCNN1A gene was associated with increased presence of acetylated histone H3 and H4 and di-methylated histone H3 at lysine (K) 4 around the transcribed region of the gene, and induction of the FXYD3 gene was associated with increased presence of acetylated histones H3 and H4 from the promoter/enhancer to the transcribed region of the gene.	Lysine	132-138	sodium channel epithelial 1 subunit alpha	Homo sapiens	17-23
24948451-6	2014	Dental curing light exposure for 300 s with riboflavin also showed a reduction in lysine concentration of DBP.	Lysine	82-88	D-box binding PAR bZIP transcription factor	Homo sapiens	106-109
24967351-7	2014	In the gonadal adipose tissues, combinations of DHA and lysine inhibited mRNA expression of lipid metabolism-associated genes, including ACC1, fatty acid synthase, lipoprotein lipase, and perilipin.	Lysine	56-62	fatty acid synthase	Mus musculus	143-162
24526115-1	2014	Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation.	Lysine	51-57	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
24526115-1	2014	Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation.	Lysine	51-57	DOT1 like histone lysine methyltransferase	Homo sapiens	5-10
25478886-4	2014	It is now widely referred to as lysine acetylation orchestrated by lysine acetyl transferase (KAT) and lysine deacetylase (KDAC) and influences many cellular functions.	Lysine	32-38	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	94-97
24899917-1	2014	The latest experimental evidence indicates that acetylation of p53 at K164 (lysine 164) and K120 may induce directly cell apoptosis under severe DNA damage.	Lysine	76-82	tumor protein p53	Homo sapiens	63-66
24496329-3	2014	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of PRC2, represses gene transcription through the tri-methylation of histone H3 lysine 27.	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
24496329-3	2014	Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of PRC2, represses gene transcription through the tri-methylation of histone H3 lysine 27.	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
23956214-3	2014	Layer-by-layer nanoimmobilization of the growth factor BMP-2 in association with chitosan (CHI) or poly-L-lysine over the nanofibers is described.	Lysine	99-112	bone morphogenetic protein 2	Mus musculus	55-60
25495986-3	2014	In particular, the methylation of lysine 27 on histone H3 (H3K27), induced by the methylase EZH2, emerges as a key control of gene expression and a major regulator of cell physiology.	Lysine	34-40	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	92-96
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Lysine	32-38	transmembrane serine protease 2	Homo sapiens	113-120
24685636-4	2014	Tissue transglutaminase (tTG) is a calcium-dependent enzyme that induces the formation of covalent epsilon-(gamma-glutamyl)lysine isopeptide bonds, which results in both intra- and intermolecular protein cross-links.	Lysine	123-129	transglutaminase 2	Homo sapiens	0-23
24685636-4	2014	Tissue transglutaminase (tTG) is a calcium-dependent enzyme that induces the formation of covalent epsilon-(gamma-glutamyl)lysine isopeptide bonds, which results in both intra- and intermolecular protein cross-links.	Lysine	123-129	transglutaminase 2	Homo sapiens	25-28
24792006-3	2014	The method employs isobaric mass tags (tandem mass tags, TMT) to enable the multiplexed quantitative analysis of up to six samples and antibodies directed against acetylated lysine residues for immunoenrichment of TMT-encoded acetylated peptides.	Lysine	174-180	tryptase gamma 1	Homo sapiens	214-217
24451981-8	2014	Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the med18 mutant, reinforcing MED18 function in different mechanisms of transcriptional control.	Lysine	52-58	mediator of RNA polymerase II transcription subunit	Arabidopsis thaliana	111-116
24077848-3	2014	Both rhodopsin families share the seven transmembrane alpha-helix GPCR fold and a Schiff base linkage from a conserved lysine to retinal in helix G. Nevertheless, rhodopsins are widely cited as a striking example of evolutionary convergence, largely because the two families lack detectable sequence similarity and differ in many structural and mechanistic details.	Lysine	119-125	rhodopsin	Homo sapiens	5-14
24190971-0	2014	LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.	Lysine	132-138	histone deacetylase 1	Homo sapiens	70-91
24190971-4	2014	Here, we found that LSD1 interacts with histone deacetylase 1 (HDAC1) to regulate the proliferation of ES/EC cells through acetylation of histone H4 at lysine 16 (H4K16), which we show is a critical substrate of HDAC1.	Lysine	152-158	histone deacetylase 1	Homo sapiens	40-61
24190971-4	2014	Here, we found that LSD1 interacts with histone deacetylase 1 (HDAC1) to regulate the proliferation of ES/EC cells through acetylation of histone H4 at lysine 16 (H4K16), which we show is a critical substrate of HDAC1.	Lysine	152-158	histone deacetylase 1	Homo sapiens	63-68
24190971-4	2014	Here, we found that LSD1 interacts with histone deacetylase 1 (HDAC1) to regulate the proliferation of ES/EC cells through acetylation of histone H4 at lysine 16 (H4K16), which we show is a critical substrate of HDAC1.	Lysine	152-158	histone deacetylase 1	Homo sapiens	212-217
24214993-5	2014	With the dataset, we totally identified 76 types of co-occurrences of various PLMs on the same lysine residues, and the most abundant PLM crosstalk is between acetylation and ubiquitination.	Lysine	95-101	FXYD domain containing ion transport regulator 1	Homo sapiens	78-81
24078251-0	2014	Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation.	Lysine	14-20	myocyte enhancer factor 2C	Mus musculus	36-61
24078251-4	2014	However, the modulation of MEF2 activity by lysine methylation, an important posttranslational modification that alters the activities of transcription factors, has not been studied.	Lysine	44-50	myocyte enhancer factor 2C	Mus musculus	27-31
24078251-5	2014	We report the reversible lysine methylation of MEF2D by G9a and LSD1 as a regulatory mechanism of MEF2D activity and skeletal muscle differentiation.	Lysine	25-31	myocyte enhancer factor 2D	Mus musculus	47-52
24214993-7	2014	Thus, the various PLM crosstalks suggested that a considerable proportion of lysines were competitively and dynamically regulated in a complicated manner.	Lysine	77-84	FXYD domain containing ion transport regulator 1	Homo sapiens	18-21
24078251-5	2014	We report the reversible lysine methylation of MEF2D by G9a and LSD1 as a regulatory mechanism of MEF2D activity and skeletal muscle differentiation.	Lysine	25-31	lysine (K)-specific demethylase 1A	Mus musculus	64-68
24078251-5	2014	We report the reversible lysine methylation of MEF2D by G9a and LSD1 as a regulatory mechanism of MEF2D activity and skeletal muscle differentiation.	Lysine	25-31	myocyte enhancer factor 2D	Mus musculus	98-103
24038750-3	2014	We further discovered that the silencing of Oct4 significantly reduces the expression of Sirt1, a deacetylase known to inhibit p53 activity and the differentiation of ESCs, leading to increased acetylation of p53 at lysine 120 and 164.	Lysine	216-222	tumor protein p53	Homo sapiens	209-212
24078251-6	2014	G9a methylates lysine-267 of MEF2D and represses its transcriptional activity, but LSD1 counteracts it.	Lysine	15-21	myocyte enhancer factor 2D	Mus musculus	29-34
24078251-9	2014	We have also identified lysine-267 as a methylation/demethylation site and demonstrate that the lysine methylation state of MEF2D regulates its transcriptional activity and skeletal muscle cell differentiation.	Lysine	24-30	myocyte enhancer factor 2D	Mus musculus	124-129
24078251-9	2014	We have also identified lysine-267 as a methylation/demethylation site and demonstrate that the lysine methylation state of MEF2D regulates its transcriptional activity and skeletal muscle cell differentiation.	Lysine	96-102	myocyte enhancer factor 2D	Mus musculus	124-129
25254241-1	2014	LOXL2 (lysyl oxidase-like 2), an enzyme that catalyzes oxidative deamination of lysine residue, is upregulated in esophageal squamous cell carcinoma (ESCC).	Lysine	80-86	lysyl oxidase like 2	Homo sapiens	0-5
25254241-1	2014	LOXL2 (lysyl oxidase-like 2), an enzyme that catalyzes oxidative deamination of lysine residue, is upregulated in esophageal squamous cell carcinoma (ESCC).	Lysine	80-86	lysyl oxidase like 2	Homo sapiens	7-27
24038750-5	2014	In addition, using knock-in approach, we revealed that the acetylation of p53 at lysine 120 and 164 is required for both stabilization and activity of p53 in hESCs.	Lysine	81-87	tumor protein p53	Homo sapiens	74-77
24038750-5	2014	In addition, using knock-in approach, we revealed that the acetylation of p53 at lysine 120 and 164 is required for both stabilization and activity of p53 in hESCs.	Lysine	81-87	tumor protein p53	Homo sapiens	151-154
24308268-5	2013	This study reports the conformation of lipid-free human apoA-I using lysine-to-lysine chemical cross-linking in conjunction with disulfide cross-linking achieved using selective cysteine mutations.	Lysine	69-75	apolipoprotein A1	Homo sapiens	56-62
24094605-1	2014	BACKGROUND: Removal of C-terminal lysine residues that are continuously exposed in lysing fibrin is an established anti-fibrinolytic mechanism dependent on the plasma carboxypeptidase TAFIa, which also removes arginines that are exposed at the time of fibrinogen clotting by thrombin.	Lysine	34-40	coagulation factor II, thrombin	Homo sapiens	275-283
24308268-5	2013	This study reports the conformation of lipid-free human apoA-I using lysine-to-lysine chemical cross-linking in conjunction with disulfide cross-linking achieved using selective cysteine mutations.	Lysine	79-85	apolipoprotein A1	Homo sapiens	56-62
24196958-4	2013	In the earlier study, we have found that the amino-terminal alpha-helical domain between Lys-33 and Lys-83 of yeast E subunit (Vma4p) in the peripheral stalk of the V1 complex has a role in glucose-dependent VoV1 assembly.	Lysine	89-92	H(+)-transporting V1 sector ATPase subunit E	Saccharomyces cerevisiae S288C	127-132
24196958-4	2013	In the earlier study, we have found that the amino-terminal alpha-helical domain between Lys-33 and Lys-83 of yeast E subunit (Vma4p) in the peripheral stalk of the V1 complex has a role in glucose-dependent VoV1 assembly.	Lysine	100-103	H(+)-transporting V1 sector ATPase subunit E	Saccharomyces cerevisiae S288C	127-132
24330748-5	2013	Immuno-precipitation/-blot studies were performed to demonstrate interactions between Id4, p53 and CBP/p300 and acetylation of specific lysine residues within p53.	Lysine	136-142	inhibitor of DNA binding 4, HLH protein	Homo sapiens	86-89
24189064-4	2013	Here we report that Tax induced the acetylation of lysine 310 of RelA and the binding of Brd4 to acetylated RelA to facilitate Tax-mediated transcriptional activation of NF-kappaB.	Lysine	51-57	nuclear factor kappa B subunit 1	Homo sapiens	170-179
24133061-4	2013	We used coimmunoprecipitation, mass spectrometry, and limited proteolysis assays to demonstrate that HSP72 interacts physically with the protein biotin ligase holocarboxylase synthetase (HLCS), leading to biotinylation of residues K112, K128 K348, K361, K415, and, probably, additional lysines.	Lysine	286-293	heat shock protein family A (Hsp70) member 1A	Homo sapiens	101-106
24133122-8	2013	Full-length SPAK is phosphorylated and activated by members of the with-no-lysine[K] (WNK) kinase family.	Lysine	75-81	serine/threonine kinase 39	Homo sapiens	12-16
24330748-5	2013	Immuno-precipitation/-blot studies were performed to demonstrate interactions between Id4, p53 and CBP/p300 and acetylation of specific lysine residues within p53.	Lysine	136-142	tumor protein p53	Homo sapiens	159-162
24349476-3	2013	Several histone lysine acetylation and methylation markers have been proven to regulate the transcription level of WUS.	Lysine	16-22	Homeodomain-like superfamily protein	Arabidopsis thaliana	115-118
24141370-2	2013	We have recently drawn correlations between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone H3 lysine 27 trimethylation.	Lysine	139-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	106-110
24215132-3	2013	Here, four PA derivatives containing arginine and lysine conjugated with fatty acyl groups with different chain lengths, namely, PA1: R-K(C14)-R, PA2: R-K(C16)-R, PA3: K(C14)-R-K(C14), and PA4: K(C16)-R-K(C16), where C16 = palmitic acid and C14 = myristic acid, were synthesized through Fmoc chemistry.	Lysine	50-56	PAXIP1 associated glutamate rich protein 1	Homo sapiens	129-132
24240174-1	2013	The histone deacetylases HDAC1 and HDAC2 remove acetyl moieties from lysine residues of histones and other proteins and are important regulators of gene expression.	Lysine	69-75	histone deacetylase 2	Mus musculus	35-40
24129573-0	2013	Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.	Lysine	83-89	interferon induced transmembrane protein 3	Homo sapiens	23-65
24129573-2	2013	Interferon-induced transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1) to reduce its antiviral activity, mediated by the lysine methyltransferase SET7.	Lysine	84-90	interferon induced transmembrane protein 3	Homo sapiens	0-42
24129573-2	2013	Interferon-induced transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1) to reduce its antiviral activity, mediated by the lysine methyltransferase SET7.	Lysine	84-90	interferon induced transmembrane protein 3	Homo sapiens	44-50
24129573-2	2013	Interferon-induced transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1) to reduce its antiviral activity, mediated by the lysine methyltransferase SET7.	Lysine	84-90	interferon induced transmembrane protein 3	Homo sapiens	103-109
24113524-8	2013	Acetylation of p53 at the SIRT1-specific lysine 379 site was markedly decreased.	Lysine	41-47	sirtuin 1	Rattus norvegicus	26-31
23887863-2	2013	When present in PRC2, EZH2 catalyzes trimethylation on lysine 27 residue of histone H3, resulting in epigenetic silencing of gene expression and cancer progression.	Lysine	55-61	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
23973428-4	2013	Pyrophosphate released by the amino acid-aaRS binding reaction was detected by luminol chemiluminescence; the method provided selective quantitation of 1.0-30 muM histidine and 1.0-60 muM lysine.	Lysine	188-194	latexin	Homo sapiens	184-187
24036101-0	2013	Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling.	Lysine	0-6	insulin like growth factor 1	Homo sapiens	19-24
24115035-7	2013	Interestingly, acetylation of histone H3 at lysine 56 mediated by histone deacetylase-3 reduction was enhanced significantly in AMPKalpha2(-/-) VSMCs compared with wild-type or AMPKalpha1(-/-) VSMCs.	Lysine	44-50	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	128-138
24115035-8	2013	Moreover, the augmented association of p52/acetylation of histone H3 at lysine 56 with the promoter of ubiquitin E3 ligase, S-phase kinase-associated protein 2, was shown in AMPKalpha2(-/-) VSMCs by chromatin immunoprecipitation assay.	Lysine	72-78	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	174-184
23871831-7	2013	FBXL19 bound the small GTPase in the cytoplasm leading to RhoA ubiquitination at Lys(135).	Lysine	81-84	ras homolog family member A	Homo sapiens	58-62
23993342-4	2013	Secondly, DOX-Trail complex was condensed by Dendrigraft poly-L-lysine (DGL) to form a nanoscaled co-delivery system.	Lysine	57-70	TNF superfamily member 10	Homo sapiens	14-19
24036101-0	2013	Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling.	Lysine	0-6	insulin like growth factor 1	Homo sapiens	86-91
24036101-3	2013	In this paper, we discuss transglutaminases (TGases) as a constituent of the ECM and provide evidence for the first time that IGF-I is a lysine (K)-donor substrate to TGases.	Lysine	137-143	insulin like growth factor 1	Homo sapiens	126-131
24125069-5	2013	Here, we report that histone acetyltransferase Hbo1 promotes destabilization of estrogen receptor alpha (ERalpha) in breast cancers through lysine 48-linked ubiquitination.	Lysine	140-146	estrogen receptor 1	Homo sapiens	80-103
24096265-12	2013	Interruption of HDAC4 signaling attenuated the glucocorticoid-induced hypoacetylation of histone H3 at lysine 9 (H3K9Ac) and restored the enrichment of H3K9Ac in miR-29a proximal promoter region and miR-29a transcription in cell cultures.	Lysine	103-109	histone deacetylase 4	Mus musculus	16-21
24125069-5	2013	Here, we report that histone acetyltransferase Hbo1 promotes destabilization of estrogen receptor alpha (ERalpha) in breast cancers through lysine 48-linked ubiquitination.	Lysine	140-146	estrogen receptor 1	Homo sapiens	105-112
23596011-6	2013	Surface adsorption of a polycation and laminin promoted significantly longer neurite growth than the uncoated scaffold (poly-L-ornithine + Laminin = 793.2 +- 187.2 mum; poly-L-lysine + Laminin = 768.7 +- 241.2 mum; uncoated scaffold = 22.52 +- 50.14 mum) (P &lt; 0.001).	Lysine	169-182	laminin, beta 2 (laminin S)	Gallus gallus	39-46
24107828-5	2013	Chromatin immune precipitation (ChIP) assays revealed that EZH2 catalyzed repressive H3 lysine 27 trimethylation (H3K27me3), which was sufficient to silence HOX genes in CLL, whereas in MCL H3K27me3 is accompanied by DNA methylation for a more stable repression.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
23872024-10	2013	Computational-based molecular modeling analysis of 4-HNE adducted to Cys(71) near the active site and Lys(327) in the C2 domain of PTEN suggested inhibition of enzyme catalysis via either stearic hindrance of the active-site pocket or prevention of C2 domain-dependent PTEN function.	Lysine	102-105	phosphatase and tensin homolog	Mus musculus	131-135
24132606-7	2013	RNA interfering and pharmacologic inhibition of EZH2 reduced histone H3 lysine 27 tri-methylation level and increased TIMP-3 expression level.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	48-52
24345883-1	2013	EZH2, a core member of the Polycomb Repressor Complex 2 (PRC2), mediates transcriptional silencing by catalyzing the trimethylation of histone 3 lysine 27 (H3K27), which plays key roles in cancer initiation and progression.	Lysine	145-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24158444-5	2013	Partial proteolysis is also observed when UBE3C is present but cannot ubiquitinate substrates because its active site has been mutated, it is unable to bind to the proteasome, or the substrate lacks lysine residues.	Lysine	199-205	ubiquitin protein ligase E3C	Homo sapiens	42-47
24129578-0	2013	Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.	Lysine	65-68	NDC80 kinetochore complex component	Homo sapiens	121-125
24129578-5	2013	Moreover, unlike most coiled-coil proteins, where the buried positions are composed of hydrophobic residues, Hec1 possessed an unusual distribution of glutamic acid residues, Glu-334, Glu-341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2 lysine residues: Lys-227, Lys-234, and Lys-241.	Lysine	290-296	NDC80 kinetochore complex component	Homo sapiens	109-113
24129578-5	2013	Moreover, unlike most coiled-coil proteins, where the buried positions are composed of hydrophobic residues, Hec1 possessed an unusual distribution of glutamic acid residues, Glu-334, Glu-341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2 lysine residues: Lys-227, Lys-234, and Lys-241.	Lysine	307-310	NDC80 kinetochore complex component	Homo sapiens	109-113
24129578-5	2013	Moreover, unlike most coiled-coil proteins, where the buried positions are composed of hydrophobic residues, Hec1 possessed an unusual distribution of glutamic acid residues, Glu-334, Glu-341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2 lysine residues: Lys-227, Lys-234, and Lys-241.	Lysine	316-319	NDC80 kinetochore complex component	Homo sapiens	109-113
24129578-5	2013	Moreover, unlike most coiled-coil proteins, where the buried positions are composed of hydrophobic residues, Hec1 possessed an unusual distribution of glutamic acid residues, Glu-334, Glu-341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2 lysine residues: Lys-227, Lys-234, and Lys-241.	Lysine	316-319	NDC80 kinetochore complex component	Homo sapiens	109-113
24129578-7	2013	Taken together, these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1-Nuf2 dimerization and NDC80 complex formation.	Lysine	76-82	NDC80 kinetochore complex component	Homo sapiens	210-214
24129578-7	2013	Taken together, these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1-Nuf2 dimerization and NDC80 complex formation.	Lysine	76-82	NDC80 kinetochore complex component	Homo sapiens	237-242
24163373-7	2013	In addition, studies from both gain- and loss-of-function models revealed that SALL4 dynamically controls the binding levels of LSD1, which is accompanied by a reversely changed histone 3 dimethylated lysine 4 at the same promoter regions.	Lysine	201-207	spalt like transcription factor 4	Mus musculus	79-84
24163373-7	2013	In addition, studies from both gain- and loss-of-function models revealed that SALL4 dynamically controls the binding levels of LSD1, which is accompanied by a reversely changed histone 3 dimethylated lysine 4 at the same promoter regions.	Lysine	201-207	lysine (K)-specific demethylase 1A	Mus musculus	128-132
24209620-4	2013	Here, we show that yeast Rtt101(Mms1) E3 ubiquitin ligase preferentially binds and ubiquitylates new histone H3 acetylated at lysine 56.	Lysine	126-132	cullin RTT101	Saccharomyces cerevisiae S288C	25-31
24183969-4	2013	These compounds inhibit wild-type and mutant versions of EZH2 with nanomolar potency, suppress global histone H3-lysine 27 methylation, affect gene expression, and cause selective proliferation defects.	Lysine	113-119	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	57-61
24072712-5	2013	Site-directed mutagenesis experiments showed that the Lys(462) residue of PPARgamma is critical for ubiquitination.	Lysine	54-57	peroxisome proliferator activated receptor gamma	Homo sapiens	74-83
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	interleukin 1 beta	Mus musculus	170-187
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	interleukin 1 beta	Mus musculus	189-197
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	interleukin 6	Mus musculus	200-204
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	chemokine (C-C motif) ligand 5	Mus musculus	249-255
24003859-9	2013	When these two residues in AtTrx-h3 were replaced with lysine, AtTrx-h3 functioned like AtTrx-h2.	Lysine	55-61	thioredoxin 3	Arabidopsis thaliana	63-71
24238339-3	2013	Ezh2 directly bound and facilitated correct expression of Tbx21 and Gata3 in differentiating Th1 and Th2 cells, accompanied by substantial trimethylation at lysine 27 of histone 3 (H3K27me3).	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
24209620-4	2013	Here, we show that yeast Rtt101(Mms1) E3 ubiquitin ligase preferentially binds and ubiquitylates new histone H3 acetylated at lysine 56.	Lysine	126-132	Mms1p	Saccharomyces cerevisiae S288C	32-36
24209620-5	2013	Inactivation of Rtt101 or mutating H3 lysine residues ubiquitylated by the Rtt101(Mms1) ligase impairs nucleosome assembly and promotes Asf1-H3 interactions.	Lysine	38-44	cullin RTT101	Saccharomyces cerevisiae S288C	75-81
24209620-5	2013	Inactivation of Rtt101 or mutating H3 lysine residues ubiquitylated by the Rtt101(Mms1) ligase impairs nucleosome assembly and promotes Asf1-H3 interactions.	Lysine	38-44	Mms1p	Saccharomyces cerevisiae S288C	82-86
32261195-2	2013	The outer shell of MSN was functionalized with K8 peptide (octa-lysine sequence) by click chemistry, followed by reacting with citraconic anhydride viaalpha,beta-unsaturated bond to prepare negatively charged MSN-K8(Cit).	Lysine	64-70	moesin	Homo sapiens	19-22
24039251-10	2013	Mass spectrometry and immunoprecipitation analyses revealed that TIMP-1 acetylation on specific lysine residues was increased, whereas its interaction with SIRT1 and MMP-9 was reduced in mouse lungs with emphysema, as well as in lungs of smokers and COPD patients.	Lysine	96-102	tissue inhibitor of metalloproteinase 1	Mus musculus	65-71
24207024-3	2013	Acetylation of PAF53 at lysine 373 by CBP and deacetylation by SIRT7 modulate the association of Pol I with DNA, hypoacetylation correlating with increased rDNA occupancy of Pol I and transcription activation.	Lysine	24-30	CREB binding protein	Homo sapiens	38-41
23756451-12	2013	Overall, acetylated histone H3 at lysine 9 was increased in spinal cord tissues after incision, and enhanced association of acetylated histone H3 at lysine 9 with the promoter regions of CXCR2 and keratinocyte-derived chemokine (CXCL1) was observed as well.	Lysine	149-155	chemokine (C-X-C motif) ligand 1	Mus musculus	229-234
24077602-8	2013	They also showed that SAFB1 interacts with EZH2, SUZ12 and EED, three core components of the Polycomb repressive complex 2 (PRC2), which catalyzes the gene repression histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	191-197	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	43-47
24096875-6	2013	The inhibition of Lys(118) acetylation promoted the generation of NOS3-promoting prosurvival form of p53.	Lysine	18-21	nitric oxide synthase 3	Homo sapiens	66-70
23973283-5	2013	F. hepatica TPI is predicted to have a beta-barrel structure and key active site residues (Lys-14, His-95 and Glu-165) are conserved.	Lysine	91-94	triosephosphate isomerase 1	Homo sapiens	12-15
24152914-6	2013	When Cu,Zn-SOD that has been exposed to acrolein was subsequently analyzed by amino acid analysis, serine, histidine, arginine, threonine and lysine residues were particularly sensitive.	Lysine	142-148	superoxide dismutase 1	Homo sapiens	11-14
23955539-7	2013	Resistin-induced WHSC1 increases the dimethylation of histone 3 at lysine 36 and decreases the trimethylation of histone 3 at lysine 27 on the promoter of Twist, resulting in an enhancement of the expression of Twist.	Lysine	67-73	nuclear receptor binding SET domain protein 2	Homo sapiens	17-22
23955539-7	2013	Resistin-induced WHSC1 increases the dimethylation of histone 3 at lysine 36 and decreases the trimethylation of histone 3 at lysine 27 on the promoter of Twist, resulting in an enhancement of the expression of Twist.	Lysine	126-132	nuclear receptor binding SET domain protein 2	Homo sapiens	17-22
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Lysine	142-145	tumor protein p53	Homo sapiens	0-3
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Lysine	142-145	tumor protein p53	Homo sapiens	95-98
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Lysine	142-145	nitric oxide synthase 3	Homo sapiens	102-106
24096875-0	2013	p53"s choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.	Lysine	142-145	tumor protein p53	Homo sapiens	95-98
24096875-6	2013	The inhibition of Lys(118) acetylation promoted the generation of NOS3-promoting prosurvival form of p53.	Lysine	18-21	tumor protein p53	Homo sapiens	101-104
24096875-5	2013	In the infarct heart, p53 was heavily acetylated at Lys(118) residue, which was exclusively reversed in the oxygenated heart, apparently regulated by oxygen-dependent expression of TIP60.	Lysine	52-55	tumor protein p53	Homo sapiens	22-25
24076604-4	2013	One signature was characterized by increased histone 3 lysine 36 (H3K36) dimethylation, exhibited by several lines harboring translocations in NSD2, which encodes a methyltransferase.	Lysine	55-61	nuclear receptor binding SET domain protein 2	Homo sapiens	143-147
24060284-8	2013	These alterations were mainly attributed to the formation of crosslink between the lysine residues of HSA upon incubation with glucose.	Lysine	83-89	albumin	Homo sapiens	102-105
23954480-2	2013	The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysine residues has been shown to disrupt PS binding.	Lysine	121-127	synaptotagmin 1	Rattus norvegicus	22-37
24400135-9	2013	A custom-made antibody targeting the C-terminal acetylated lysine of human HSPB6 identified this as a novel target of acetylation that was increased by KDAC inhibition.	Lysine	59-65	heat shock protein family B (small) member 6	Homo sapiens	75-80
24339737-0	2013	The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.	Lysine	65-71	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	49-53
24339737-1	2013	The histone methyltransferase enhancer of zeste 2 (EZH2) is known to be a polycomb protein homologous to Drosophila enhancer of zeste and catalyzes the addition of methyl groups to histone H3 at lysine 27 (H3K27).	Lysine	195-201	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	51-55
24339737-3	2013	In the present study, we demonstrated that EZH2 has the function to monomethylate lysine 120 on histone H2B (H2BK120).	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	43-47
24078263-4	2013	Since theoretical analysis of the amino acid sequence of CacyBP/SIP indicated several lysine residues which could potentially be sumoylated we checked experimentally whether this protein might be modified by SUMO attachment.	Lysine	86-92	calcyclin binding protein	Mus musculus	57-63
24078263-4	2013	Since theoretical analysis of the amino acid sequence of CacyBP/SIP indicated several lysine residues which could potentially be sumoylated we checked experimentally whether this protein might be modified by SUMO attachment.	Lysine	86-92	calcyclin binding protein	Mus musculus	64-67
24078263-7	2013	We have also established that lysine 16 is the residue which undergoes sumoylation in the CacyBP/SIP protein.	Lysine	30-36	calcyclin binding protein	Mus musculus	90-96
24078263-7	2013	We have also established that lysine 16 is the residue which undergoes sumoylation in the CacyBP/SIP protein.	Lysine	30-36	calcyclin binding protein	Mus musculus	97-100
23786586-4	2013	In this article, poly-L-lysine-coated vascular endothelial growth factor/alginate controlled releasing microspheres (VEGF-AG-PLL) were fabricated in tissue-engineered bone (TEB), and then the composite was implanted into the CSBD of goat femurs.	Lysine	17-30	vascular endothelial growth factor A	Capra hircus	117-121
23590130-7	2013	A BRAF mutation was found only in 14 (24%) tumors with the FNAC diagnosis of PTC or suspicious for PTC: 13 cases with the usual c.1799T&gt;A (p.V600E) mutation and 1 case with a 3 base-pair deletion (c.1799_1801delTGA), resulting in a deletion of lysine at codon 601 and a deletion c.1799_1801delTGA that results in a valine-to-glutamate substitution at codon 600 (p.V600_K601&gt;E) while preserving the reading frame.	Lysine	247-253	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	2-6
23855659-4	2013	The monoPEGylated and diPEGylated amylin products were generated rapidly through conjugation to the two amino groups of the N-terminal lysine residue.	Lysine	135-141	islet amyloid polypeptide	Mus musculus	34-40
24108357-4	2013	Our results suggest that SUMOylation of Snf1 inhibits its function in two ways: by interaction of SUMO attached to lysine 549 with a SUMO-interacting sequence motif located near the active site of Snf1, and by targeting Snf1 for destruction via the Slx5-Slx8 (SUMO-directed) ubiquitin ligase.	Lysine	115-121	SUMO-targeted ubiquitin ligase complex subunit SLX8	Saccharomyces cerevisiae S288C	254-258
24044355-2	2013	STIM1 (stromal interaction molecule 1) and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoinositides at the PM via their cytosolic lysine (K)-rich domains, and activate Ca2+ channels.	Lysine	167-173	stromal interaction molecule 1	Homo sapiens	0-5
24044355-2	2013	STIM1 (stromal interaction molecule 1) and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoinositides at the PM via their cytosolic lysine (K)-rich domains, and activate Ca2+ channels.	Lysine	167-173	stromal interaction molecule 1	Homo sapiens	7-37
24032713-6	2013	Enhancer of zeste homologue 2 (EZH2), an important histone-modifying enzyme, is able to trimethylate histone 3 on lysine 27 (H3K27Me3), consequently leading to gene silencing, especially silencing of tumor suppressor genes such as p53.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-29
24032713-6	2013	Enhancer of zeste homologue 2 (EZH2), an important histone-modifying enzyme, is able to trimethylate histone 3 on lysine 27 (H3K27Me3), consequently leading to gene silencing, especially silencing of tumor suppressor genes such as p53.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
24032713-6	2013	Enhancer of zeste homologue 2 (EZH2), an important histone-modifying enzyme, is able to trimethylate histone 3 on lysine 27 (H3K27Me3), consequently leading to gene silencing, especially silencing of tumor suppressor genes such as p53.	Lysine	114-120	tumor protein p53	Homo sapiens	231-234
24160175-9	2013	Consistent with this we found altered lysine acetylation levels and deacetylase activity in the brains of SCA7 transgenic mice.	Lysine	38-44	ataxin 7	Mus musculus	106-110
24055344-3	2013	The Rpd3S histone deacetylase complex is recruited by elongating RNA polymerase II to remove histone acetylation at coding regions in a manner that is dependent on methylation of lysine 36 on histone 3 (H3K36me), and Rpd3S prefers dinucleosomes.	Lysine	179-185	histone deacetylase 1	Homo sapiens	4-8
24055344-3	2013	The Rpd3S histone deacetylase complex is recruited by elongating RNA polymerase II to remove histone acetylation at coding regions in a manner that is dependent on methylation of lysine 36 on histone 3 (H3K36me), and Rpd3S prefers dinucleosomes.	Lysine	179-185	histone deacetylase 1	Homo sapiens	217-221
24194938-0	2013	Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro.	Lysine	15-21	tumor protein p53	Homo sapiens	100-103
24075995-4	2013	Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo.	Lysine	83-89	HOX transcript antisense RNA (non-protein coding)	Mus musculus	0-6
24194938-5	2013	We further show that both acetylation of lysine 382 and phosphorylation of serine 392 in p53 enhance the interaction between p53 and MDC1.	Lysine	41-47	tumor protein p53	Homo sapiens	125-128
24101509-5	2013	Here we show that SET and MYND domain containing 2 (SMYD2), a histone H3K4 and H3K36 methyltransferase, directly methylates ERalpha protein at lysine 266 (K266) both in vitro and in cells.	Lysine	143-149	estrogen receptor 1	Homo sapiens	124-131
24014025-5	2013	Both forms of LOXL2 can oxidize lysine in solution.	Lysine	32-38	lysyl oxidase like 2	Homo sapiens	14-19
24019517-1	2013	In most cells, cationic amino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L (y(+)LAT) amino acid transporters.	Lysine	56-64	catalase	Homo sapiens	111-114
24075995-4	2013	Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo.	Lysine	83-89	lysine (K)-specific demethylase 1A	Mus musculus	106-110
24147034-0	2013	The effect of N-acetylation and N-methylation of lysine residue of Tat peptide on its interaction with HIV-1 TAR RNA.	Lysine	49-55	RNA binding motif protein 8A	Homo sapiens	109-112
24075995-4	2013	Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo.	Lysine	153-159	HOX transcript antisense RNA (non-protein coding)	Mus musculus	0-6
24147034-4	2013	Here we have delineated the thermodynamic and kinetic effects of N-acetylation and N-monomethylation of lysine on interaction between HIV-1 TAR RNA and its cognate binder Tat peptide ( a model system).	Lysine	104-110	RNA binding motif protein 8A	Homo sapiens	140-143
24075995-4	2013	Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo.	Lysine	153-159	lysine (K)-specific demethylase 1A	Mus musculus	106-110
24130751-7	2013	GCN2 and nutrition-dependent programming of Ppargamma2 is correlated with trimethylation of lysine 4 of histone 3 (H3K4me3) in the Ppargamma2 promoter region during neonatal development.	Lysine	92-98	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	0-4
23974119-7	2013	Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.	Lysine	186-193	sirtuin 6	Mus musculus	43-48
24100334-5	2013	It is also advised to avoid DMSO when searching for low-affinity fragments that interact with bromodomains since DMSO binds in the acetylated lysine-recognition pocket of BRD4.	Lysine	142-148	bromodomain containing 4	Homo sapiens	171-175
23979357-6	2013	Cotransfection studies indicated that ubiquilin 1 localizes TREX1 to cytosolic punctate structures dependent upon the TREX1 CTR and lysines within the TREX1 catalytic core.	Lysine	132-139	ubiquilin 1	Homo sapiens	38-49
24088713-3	2013	SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1.	Lysine	67-73	tumor protein p53	Homo sapiens	164-167
23800578-0	2013	PEGylation of lysine residues reduces the pro-migratory activity of IGF-I.	Lysine	14-20	insulin like growth factor 1	Homo sapiens	68-73
23800578-7	2013	RESULTS: IGF-I PEGylated at lysines 27 (PEG-K27), 65 (PEG-K65) or 68 (PEG-K68) was employed.	Lysine	28-35	insulin like growth factor 1	Homo sapiens	9-14
24138621-4	2013	By profiling both protein and acetylation variations in multiple samples using this microarray, we found cancer-associated lysine acetylation alteration on VEGF in the serum of hepatocellular carcinoma patients.	Lysine	123-129	vascular endothelial growth factor A	Homo sapiens	156-160
24000826-0	2013	Enzyme-dependent lysine deprotonation in EZH2 catalysis.	Lysine	17-23	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	41-45
24000826-2	2013	The catalytic subunit of Polycomb Repressive Complex 2, EZH2 (EC 2.1.1.43), is a PKMT and a member of a family of SET domain lysine methyltransferases that catalyze the transfer of a methyl group from S-adenosyl-l-methionine to lysine 27 of histone 3 (H3K27).	Lysine	125-131	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	56-60
24004944-4	2013	KIS promotes transcription elongation, facilitates the binding of the trithorax group histone methyltransferases ASH1 and TRX to active genes, and counteracts repressive methylation of histone H3 on lysine 27 (H3K27) by Polycomb group proteins.	Lysine	199-205	kismet	Drosophila melanogaster	0-3
24013425-3	2013	We describe here that Akt is modified by SUMO conjugation, and show that lysine residues 276 and 301 are the major SUMO attachment sites within this protein.	Lysine	73-79	AKT serine/threonine kinase 1	Homo sapiens	22-25
24004944-9	2013	Mutations in kis cause a global reduction in the di- and tri-methylation of histone H3 on lysine 36 (H3K36) - modifications that antagonize H3K27 methylation in vitro.	Lysine	90-96	kismet	Drosophila melanogaster	13-16
23925126-9	2013	Acetylation on previously identified lysines of Htz1 plays little role in NER or cell survival after UV.	Lysine	37-44	histone H2AZ	Saccharomyces cerevisiae S288C	48-52
23907094-2	2013	We found that PCBs activate AR transcriptional activity and that this effect is potentiated by the demethylase Jarid1b, a histone demethylase that catalyzes the removal of trimethylation of lysine 4 on histone H3 (H3K4me3), induced by PCB.	Lysine	190-196	pyruvate carboxylase	Homo sapiens	14-17
23881913-6	2013	On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.	Lysine	138-145	sirtuin 6	Mus musculus	26-31
23881913-6	2013	On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.	Lysine	138-145	sirtuin 6	Mus musculus	105-110
23918806-2	2013	The pathogenic role of enhancer of zeste homolog 2 (EZH2) has been connected to its histone 3 lysine 27 (H3K27) methyltransferase activity and gene repression; however, little is known about relationship of changes in expression of EZH2 target genes to cancer characteristics and patient prognosis.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	23-50
23918806-2	2013	The pathogenic role of enhancer of zeste homolog 2 (EZH2) has been connected to its histone 3 lysine 27 (H3K27) methyltransferase activity and gene repression; however, little is known about relationship of changes in expression of EZH2 target genes to cancer characteristics and patient prognosis.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	52-56
24003256-1	2013	The innate and adaptive immune responses involve the stimulation of nuclear factor kappaB (NF-kappaB) transcription factors through the Lys(63) (K(63))-linked ubiquitylation of specific components of NF-kappaB signaling pathways.	Lysine	136-139	nuclear factor kappa B subunit 1	Homo sapiens	91-100
24298606-0	2013	Lysine-specific modifications of p53: a matter of life and death?	Lysine	0-6	tumor protein p53	Homo sapiens	33-36
24298606-3	2013	In this review, we focus on the role of recently discovered lysine-specific modifications of p53, methylation and acetylation in particular, and their effects on p53 activity in damaged cells.	Lysine	60-66	tumor protein p53	Homo sapiens	93-96
24298606-3	2013	In this review, we focus on the role of recently discovered lysine-specific modifications of p53, methylation and acetylation in particular, and their effects on p53 activity in damaged cells.	Lysine	60-66	tumor protein p53	Homo sapiens	162-165
23798677-5	2013	We also show that mutation of Asp-101, the intermolecular salt bridge partner of Lys-99, similarly blocks transformation of NIH3T3 cells by EN, reduces EN tyrosine phosphorylation, inhibits Akt and Mek1/2 signaling downstream of EN, and abolishes tumor formation in nude mice.	Lysine	81-84	thymoma viral proto-oncogene 1	Mus musculus	190-193
24019463-3	2013	We used mass spectrometry-based targeted proteomics to show that activated epidermal growth factor receptor (EGFR) is ubiquitinated by one to two short (two to three ubiquitins) polyubiquitin chains mainly linked via lysine 63 (K63) or conjugated with a single monoubiquitin.	Lysine	217-223	epidermal growth factor receptor	Homo sapiens	75-107
24019463-3	2013	We used mass spectrometry-based targeted proteomics to show that activated epidermal growth factor receptor (EGFR) is ubiquitinated by one to two short (two to three ubiquitins) polyubiquitin chains mainly linked via lysine 63 (K63) or conjugated with a single monoubiquitin.	Lysine	217-223	epidermal growth factor receptor	Homo sapiens	109-113
23891621-2	2013	Our data indicate that other AF9 binding proteins compete with the histone methyltransferase DOT1L for AF9 binding thus diminishing its ability to methylate lysine 79 of histone 3.	Lysine	157-163	MLLT3 super elongation complex subunit	Homo sapiens	29-32
23891621-2	2013	Our data indicate that other AF9 binding proteins compete with the histone methyltransferase DOT1L for AF9 binding thus diminishing its ability to methylate lysine 79 of histone 3.	Lysine	157-163	DOT1 like histone lysine methyltransferase	Homo sapiens	93-98
23891621-2	2013	Our data indicate that other AF9 binding proteins compete with the histone methyltransferase DOT1L for AF9 binding thus diminishing its ability to methylate lysine 79 of histone 3.	Lysine	157-163	MLLT3 super elongation complex subunit	Homo sapiens	103-106
23884910-4	2013	Systematically analyzing the role of lysine residues in Akt activation revealed that K276, which is located in a SUMOylation consensus motif, is essential for Akt activation.	Lysine	37-43	AKT serine/threonine kinase 1	Homo sapiens	56-59
23884910-4	2013	Systematically analyzing the role of lysine residues in Akt activation revealed that K276, which is located in a SUMOylation consensus motif, is essential for Akt activation.	Lysine	37-43	AKT serine/threonine kinase 1	Homo sapiens	159-162
24004664-6	2013	Our experimental data confirm a role for the KEN lysine as an ubiquitin acceptor contributing to substrate destruction during mitotic progression.	Lysine	49-55	pericentrin	Homo sapiens	45-48
23904252-2	2013	The formation of Abeta fibrils and oligomers requires a conformational change from an alpha-helix to a beta-sheet conformation, which is encouraged by the formation of a salt bridge between Asp 23 or Glu 22 and Lys 28.	Lysine	211-214	amyloid beta precursor protein	Homo sapiens	17-22
23904252-11	2013	Then, ligands that bind Asp 23 or Glu 22 and Lys 28 could therefore be used to prevent beta turn formation and, consequently, the formation of Abeta fibrils.	Lysine	45-48	amyloid beta precursor protein	Homo sapiens	143-148
24077318-4	2013	The Lys-MIP also showed selective detection for Lys among other proteins such as cytochrome C (Cyt C), hemoglobin (HB) and bovine serum albumin (BSA) due to the imprinted sites in the Lys-MIP.	Lysine	4-7	cytochrome c, somatic	Homo sapiens	81-93
24077318-4	2013	The Lys-MIP also showed selective detection for Lys among other proteins such as cytochrome C (Cyt C), hemoglobin (HB) and bovine serum albumin (BSA) due to the imprinted sites in the Lys-MIP.	Lysine	4-7	cytochrome c, somatic	Homo sapiens	95-100
24077318-4	2013	The Lys-MIP also showed selective detection for Lys among other proteins such as cytochrome C (Cyt C), hemoglobin (HB) and bovine serum albumin (BSA) due to the imprinted sites in the Lys-MIP.	Lysine	4-7	albumin	Homo sapiens	130-143
24086544-8	2013	Site directed mutagenesis of the LRP1 ligand, RBD, in which Lys(1370) and Lys(1374) are converted to alanine to preclude LRP1 binding, were ineffective in promoting cell signaling, survival or inducing neurite extension in primary sensory neurons, confirming LRP1 specificity.	Lysine	60-63	LDL receptor related protein 1	Homo sapiens	33-37
23998537-4	2013	The developed approach allowed linear lysine responses from 0.02 mM up to 2 mM with a sensitivity of 41 nA/(mM x mm(2)) and a detection limit of 4 muM (S/N=3).	Lysine	38-44	latexin	Homo sapiens	147-150
23973329-5	2013	In addition, the TGF-beta receptor-TRAF4 interaction triggers Lys 63-linked TRAF4 polyubiquitylation and subsequent activation of the TGF-beta-activated kinase (TAK)1.	Lysine	62-65	transforming growth factor beta 1	Homo sapiens	17-25
24003256-1	2013	The innate and adaptive immune responses involve the stimulation of nuclear factor kappaB (NF-kappaB) transcription factors through the Lys(63) (K(63))-linked ubiquitylation of specific components of NF-kappaB signaling pathways.	Lysine	136-139	nuclear factor kappa B subunit 1	Homo sapiens	200-209
24047271-1	2013	The histone lysine methyltransferase EZH2 is the catalytic component of the multi-protein PRC2 complex and methylates lysine 27 on histone H3.	Lysine	12-18	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	37-41
23884442-8	2013	Further dissection of the DCC via RNAi revealed that other complex members phenocopy the dpy-21 suppression of rict-1, as did RNAi to the DCC effectors set-1 and set-4, which methylate histone 4 on lysine 20 (H4K20).	Lysine	198-204	Histone-lysine N-methyltransferase Suv4-20	Caenorhabditis elegans	162-167
24076975-8	2013	These results suggest that Fni3/Sl-Ubc13-2 and Suv regulate the immune response mediated by Fen and other R proteins through Lys-63-linked ubiquitination.	Lysine	125-128	serine/threonine protein kinase Fen	Solanum lycopersicum	92-95
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	109-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
24068929-6	2013	This cell culture system allowed us to demonstrate that cccDNA transcription required histone deacetylase activity and IFN-alpha induced a profound and long-lasting suppression of cccDNA transcription, which required protein synthesis and was associated with the reduction of acetylated histone H3 lysine 9 (H3K9) and 27 (H3K27) in cccDNA minichromosomes.	Lysine	298-304	interferon alpha 1	Homo sapiens	119-128
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	109-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	69-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	109-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
23862699-2	2013	As these deficiencies coincide with aberrant levels of histone acetylation, we hypothesized that the key difference between p300 and CBP activity is differences in their specificity/selectivity for lysines within the histones.	Lysine	198-205	CREB binding protein	Homo sapiens	133-136
23862699-9	2013	This discovery of unique specificity for targets of CBP- vs p300-mediated acetylation of histone lysine residues presents a new model for understanding their respective biological roles and possibly an opportunity for selective therapeutic intervention.	Lysine	97-103	CREB binding protein	Homo sapiens	52-55
23928698-4	2013	A triple Lys mutant of Aurora B (K102/103/(207R)) exhibited optimal resistance to SCF(FBXL2)-directed polyubiquitination, and overexpression of this variant resulted in a significant delay in anaphase onset, resulting in apoptosis.	Lysine	9-12	F-box and leucine-rich repeat protein 2	Mus musculus	86-91
24013390-5	2013	The downregulation of cellular FLICE inhibitory protein long isoform (c-FLIPL) in the extrinsic pathway was accomplished through ubiquitination at lysine residue (K) 195 and protein synthesis inhibition.	Lysine	147-153	CASP8 and FADD like apoptosis regulator	Homo sapiens	70-77
23798683-0	2013	Quantitative dissection of the binding contributions of ligand lysines of the receptor-associated protein (RAP) to the low density lipoprotein receptor-related protein (LRP1).	Lysine	63-70	LDL receptor related protein 1	Homo sapiens	169-173
23911286-2	2013	Here, we identify PHRF1 as a ubiquitin ligase that enforces TGIF decay by driving its ubiquitination at lysine 130.	Lysine	104-110	PHD and ring finger domains 1	Homo sapiens	18-23
23911286-2	2013	Here, we identify PHRF1 as a ubiquitin ligase that enforces TGIF decay by driving its ubiquitination at lysine 130.	Lysine	104-110	TGFB induced factor homeobox 1	Homo sapiens	60-64
23904475-3	2013	Although phosphorylation, acetylation, ubiquitination, and lysine methylation of NF-kappaB have been well described, arginine methylation has not yet been found.	Lysine	59-65	nuclear factor kappa B subunit 1	Homo sapiens	81-90
23904479-0	2013	Role of lysine methylation of NF-kappaB in differential gene regulation.	Lysine	8-14	nuclear factor kappa B subunit 1	Homo sapiens	30-39
23904479-1	2013	Lysine methylation of the p65 subunit of nuclear factor kappaB (NF-kappaB) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	64-73
24027420-0	2013	Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3zeta, MSK1, and MKP1.	Lysine	77-83	dual specificity phosphatase 1	Homo sapiens	159-163
23922389-4	2013	A complex between C1s and a collagen-like peptide containing the C1r/C1s-binding motif of C1q shows that the collagen binds to a shallow groove via a critical lysine side chain that contacts Ca(2+)-coordinating residues.	Lysine	159-165	complement C1s	Homo sapiens	18-21
23922389-4	2013	A complex between C1s and a collagen-like peptide containing the C1r/C1s-binding motif of C1q shows that the collagen binds to a shallow groove via a critical lysine side chain that contacts Ca(2+)-coordinating residues.	Lysine	159-165	complement C1r	Homo sapiens	65-72
23796753-8	2013	The B1 receptor agonist, Lys-[des-Arg9]-BK, displayed poor activity or was without effect while overall BK effects were prevented by the selective B2 receptor antagonist, fasitibant chloride, but not by the B1 selective antagonist, Lys-[Leu8][des-Arg9]-BK.	Lysine	25-28	bradykinin receptor B1	Homo sapiens	4-15
23796753-8	2013	The B1 receptor agonist, Lys-[des-Arg9]-BK, displayed poor activity or was without effect while overall BK effects were prevented by the selective B2 receptor antagonist, fasitibant chloride, but not by the B1 selective antagonist, Lys-[Leu8][des-Arg9]-BK.	Lysine	25-28	kininogen 1	Homo sapiens	40-42
23851690-7	2013	The NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific enrichment of histone 3 lysine 4 trimethylation (H3K4me3), which is indicative of open chromatin state and marks transcription-competent promoters.	Lysine	216-222	nuclear factor kappa B subunit 1	Homo sapiens	4-13
23604405-1	2013	Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, alpha-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties.	Lysine	144-150	nardilysin convertase	Homo sapiens	0-10
23604405-1	2013	Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, alpha-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties.	Lysine	144-150	glucagon	Homo sapiens	100-108
23649778-7	2013	Results from subsequent Western blot analyses that employed anti-ubiquitin or monoclonal antibodies against polyubiquitination at lysine 48 and 63 suggest that ubiquitin-binding domains from Dsk2 and ubiquilin-1 have the broadest specificity in that they captured most types of ubiquitination, whereas the binding domain from NBR1 was more selective to polyubiquitination.	Lysine	130-136	ubiquilin 1	Homo sapiens	191-195
23652029-1	2013	The ESET (also called SETDB1) protein contains an N-terminal tudor domain that mediates protein-protein interactions and a C-terminal SET domain that catalyzes methylation of histone H3 at lysine 9.	Lysine	189-195	SET domain, bifurcated 1	Mus musculus	4-8
23652029-1	2013	The ESET (also called SETDB1) protein contains an N-terminal tudor domain that mediates protein-protein interactions and a C-terminal SET domain that catalyzes methylation of histone H3 at lysine 9.	Lysine	189-195	SET domain, bifurcated 1	Mus musculus	22-28
23359523-0	2013	Human Ng2+ adipose stem cells loaded in vivo on a new crosslinked hyaluronic acid-Lys scaffold fabricate a skeletal muscle tissue.	Lysine	82-85	chondroitin sulfate proteoglycan 4	Homo sapiens	6-9
23782009-1	2013	Setdb1 is a histone H3-lysine 9 (H3K9)-specific methyltransferase that interacts with various transcriptional regulators to induce local heterochromatin formation and participates as an indispensable component in building promyelocytic leukemia nuclear body (PML-NB), which is involved in various biological processes.	Lysine	23-29	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
23740527-5	2013	Western blot analysis using an antibody against acetyl-nuclear factor-kappaB (NF-kappaB) demonstrated that PCAF mediated the Abeta-induced activation of NF-kappaB by acetylation at Lys-122.	Lysine	181-184	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-76
23740527-5	2013	Western blot analysis using an antibody against acetyl-nuclear factor-kappaB (NF-kappaB) demonstrated that PCAF mediated the Abeta-induced activation of NF-kappaB by acetylation at Lys-122.	Lysine	181-184	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-87
23740527-5	2013	Western blot analysis using an antibody against acetyl-nuclear factor-kappaB (NF-kappaB) demonstrated that PCAF mediated the Abeta-induced activation of NF-kappaB by acetylation at Lys-122.	Lysine	181-184	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
23649778-7	2013	Results from subsequent Western blot analyses that employed anti-ubiquitin or monoclonal antibodies against polyubiquitination at lysine 48 and 63 suggest that ubiquitin-binding domains from Dsk2 and ubiquilin-1 have the broadest specificity in that they captured most types of ubiquitination, whereas the binding domain from NBR1 was more selective to polyubiquitination.	Lysine	130-136	ubiquilin 1	Homo sapiens	200-211
23775793-8	2013	Furthermore, both p53 binding and transactivation were associated with increased active histone modification histone H3 lysine 4 trimethylation.	Lysine	120-126	tumor protein p53	Homo sapiens	18-21
23733925-3	2013	METHODS: Four PSMA inhibitors derived from the glutamate-urea-glutamate or glutamate-urea-lysine pharmacophores conjugated to CIM or TIM chelators were radiolabeled with (99m)Tc and evaluated in vitro and in vivo.	Lysine	90-96	folate hydrolase 1	Homo sapiens	14-18
23740990-6	2013	A tyrosine (Y) at position 364 and a lysine (K) at position 379 (the YK epitope), which are immediate neighbors on the AD-4 surface, were found to be essential for binding of the human MAbs.	Lysine	37-43	presenilin 2	Homo sapiens	119-123
23723241-4	2013	Emerging evidence has implicated a small number of histone methyltransferase (HMT) and histone demethylase (HDM) enzymes as regulators of ER signalling, including the histone H3 lysine 9 tri-/di-methyl HDM enzyme KDM4B.	Lysine	178-184	lysine demethylase 4B	Homo sapiens	213-218
23630199-8	2013	Geminin directly binds several of these genes, while Geminin knockdown in mesendodermal cells reduces Polycomb repressor complex occupancy at these loci and increases trimethylation of histone H3 lysine 4, which correlates with active gene expression.	Lysine	196-202	geminin	Mus musculus	53-60
23760262-1	2013	PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis.	Lysine	45-51	cyclin A2	Homo sapiens	24-32
22907428-7	2013	Further mechanistic investigation uncovered a new epigenetic silencing mode of APC by YY1 through recruitment of EZH2 and trimethylation of histone 3 lysine 27 on its promoter region.	Lysine	150-156	YY1 transcription factor	Homo sapiens	86-89
23868064-1	2013	Sirtuin 3 (Sirt3), a major mitochondrial NAD(+)-dependent deacetylase, targets various mitochondrial proteins for lysine deacetylation and regulates important cellular functions such as energy metabolism, aging, and stress response.	Lysine	114-120	sirtuin 3	Homo sapiens	0-9
23868064-1	2013	Sirtuin 3 (Sirt3), a major mitochondrial NAD(+)-dependent deacetylase, targets various mitochondrial proteins for lysine deacetylation and regulates important cellular functions such as energy metabolism, aging, and stress response.	Lysine	114-120	sirtuin 3	Homo sapiens	11-16
23679895-7	2013	To test this proposition, we conducted comparative enzymatic analysis of human EZH2 and vSET and report that, although both enzymes share similar preferences for methylation of H3K27, they diverge in terms of their permissiveness for catalysing methylation of alternative histone lysine sites, their relative preferences for utilization of multimeric macromolecular substrates, their active site primary sequences and, most importantly, their sensitivity to inhibition by drug-like small molecules.	Lysine	280-286	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	79-83
23565972-8	2013	Of the multiple amino acids substituted for Arg383, only lysine partially rescues the catalytic activity of Sts-1.	Lysine	57-63	ubiquitin associated and SH3 domain containing B	Homo sapiens	108-113
23727580-8	2013	We also show that increased HDAC6 activity resulting from ROCK signaling activation reduced beta-catenin acetylation at Lys-49, which was also accompanied by its decreased phosphorylation by Caesin kinase 1 (CK1) and Glycogen synthase kinase 3beta (GSK3beta), thus preventing its proteasomal degradation.	Lysine	120-123	histone deacetylase 6	Homo sapiens	28-33
23760478-0	2013	53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.	Lysine	48-51	BP1	Homo sapiens	2-5
23760478-6	2013	53BP1 binds to nucleosomes minimally as a dimer using its previously characterized methyl-lysine-binding Tudor domain and a carboxy-terminal extension, termed the ubiquitination-dependent recruitment (UDR) motif, which interacts with the epitope formed by H2AK15ub and its surrounding residues on the H2A tail.	Lysine	90-96	BP1	Homo sapiens	2-5
23874665-2	2013	Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription regulation and apoptosis, its function in these and other processes remains poorly defined.	Lysine	52-58	histone H2B	Gallus gallus	37-48
23874665-8	2013	Moreover, hMSL2 mediates modification, presumably ubiquitylation, of a key DNA repair mediator 53BP1 at lysine 1690.	Lysine	104-110	MSL complex subunit 2	Homo sapiens	10-15
23748155-5	2013	We show that in neurofibroma, the induction of Jmjd3 (jumonji domain containing 3, histone lysine demethylase) removes trimethyl groups on lysine-27 of histone-H3 and epigenetically activates the Ink4a/Arf-locus, forcing Schwann cells towards replicative senescence.	Lysine	91-97	cyclin dependent kinase inhibitor 2A	Homo sapiens	196-201
23868210-2	2013	Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an engineered lysine-25 residue.	Lysine	145-151	calcitonin related polypeptide alpha	Homo sapiens	47-51
23868210-4	2013	PEGylated Ac-Trp-[Cit(11,18),hArg(24),Lys(25),Asp(31),Pro(34),1-Nal(35)]CGRP(8-37)-NH2, 9, elicits a dose-dependent reduction of intradermal CGRP-induced local blood flow in rodents with an ED50 of 0.52 mg kg(-1) without any overt adverse effects.	Lysine	38-41	calcitonin related polypeptide alpha	Homo sapiens	72-76
23557258-4	2013	In this study, we show that the histone H3 lysine 9 (H3K9) methyltransferase SUV39H1 is clearly involved in regulating cell migration in vitro.	Lysine	43-49	SUV39H1 histone lysine methyltransferase	Homo sapiens	77-84
23486015-6	2013	Our results show that PELP1 recognizes histones modified by arginine and lysine dimethylation.	Lysine	73-79	proline, glutamate and leucine rich protein 1	Homo sapiens	22-27
23934123-7	2013	ChIP assays demonstrated that activation of the HGF-MET pathway resulted in increased occupancy of the MLL-ETS2 complex on MMP1 and MMP3 promoters, where MLL trimethylated histone H3 lysine 4 (H3K4), activating transcription.	Lysine	183-189	lysine (K)-specific methyltransferase 2A	Mus musculus	154-157
23690534-8	2013	Coimmunoprecipitation and mass spectrometry analyses revealed that MOS9 associates with the Set1 class lysine 4 of histone 3 (H3K4) methyltransferase Arabidopsis Trithorax-Related7 (ATXR7).	Lysine	103-109	SET domain protein 25	Arabidopsis thaliana	182-187
23934123-7	2013	ChIP assays demonstrated that activation of the HGF-MET pathway resulted in increased occupancy of the MLL-ETS2 complex on MMP1 and MMP3 promoters, where MLL trimethylated histone H3 lysine 4 (H3K4), activating transcription.	Lysine	183-189	lysine (K)-specific methyltransferase 2A	Mus musculus	103-106
23678181-9	2013	It was found that the V protein inhibited TRAF6-mediated lysine 63 (K63)-linked polyubiquitination of IRF7, which is prerequisite for IRF7 activation.	Lysine	57-63	interferon regulatory factor 7	Homo sapiens	102-106
23678181-9	2013	It was found that the V protein inhibited TRAF6-mediated lysine 63 (K63)-linked polyubiquitination of IRF7, which is prerequisite for IRF7 activation.	Lysine	57-63	interferon regulatory factor 7	Homo sapiens	134-138
23424038-8	2013	EZH2 regulates the histone trimethylation of lysine 27 (H3K27me3) in the VDR promoter.	Lysine	45-51	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
23673667-6	2013	Mutation of each lysine residue revealed that Lys-35 is the major SUMOylation site on Maf1 and that the deSUMOylase, SENP1, is responsible for controlling Maf1K35 SUMOylation.	Lysine	17-23	SUMO specific peptidase 1	Homo sapiens	117-122
23673667-6	2013	Mutation of each lysine residue revealed that Lys-35 is the major SUMOylation site on Maf1 and that the deSUMOylase, SENP1, is responsible for controlling Maf1K35 SUMOylation.	Lysine	46-49	SUMO specific peptidase 1	Homo sapiens	117-122
23826380-1	2013	Enhancer of zeste homolog 2 (EZH2), the histone methyltransferase of the Polycomb Repressive complex 2 catalyzing histone H3 lysine 27 tri-methylation (H3K27me3), is frequently up-regulated in human cancers.	Lysine	125-131	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
23826380-1	2013	Enhancer of zeste homolog 2 (EZH2), the histone methyltransferase of the Polycomb Repressive complex 2 catalyzing histone H3 lysine 27 tri-methylation (H3K27me3), is frequently up-regulated in human cancers.	Lysine	125-131	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
23636332-6	2013	We also show that the SHH1 SAWADEE domain is a novel chromatin-binding module that adopts a unique tandem Tudor-like fold and functions as a dual lysine reader, probing for both unmethylated K4 and methylated K9 modifications on the histone 3 (H3) tail.	Lysine	146-152	SAWADEE HOMEODOMAIN protein	Arabidopsis thaliana	22-26
23499527-11	2013	At the molecular level, nuclear heparanase appears to regulate histone 3 lysine 4 (H3K4) methylation by influencing the recruitment of demethylases to transcriptionally active genes.	Lysine	73-79	heparanase	Homo sapiens	32-42
23636332-7	2013	Finally, we show that key residues within both lysine-binding pockets of SHH1 are required in vivo to maintain siRNA and DNA methylation levels as well as Pol-IV occupancy at RdDM targets, demonstrating a central role for methylated H3K9 binding in SHH1 function and providing the first insights into the mechanism of Pol-IV targeting.	Lysine	47-53	SAWADEE HOMEODOMAIN protein	Arabidopsis thaliana	73-77
23636332-7	2013	Finally, we show that key residues within both lysine-binding pockets of SHH1 are required in vivo to maintain siRNA and DNA methylation levels as well as Pol-IV occupancy at RdDM targets, demonstrating a central role for methylated H3K9 binding in SHH1 function and providing the first insights into the mechanism of Pol-IV targeting.	Lysine	47-53	SAWADEE HOMEODOMAIN protein	Arabidopsis thaliana	249-253
22824796-3	2013	Tumor with mutations in IDH1 or IDH2 had lower 5-hydroxymethylcytosine and higher 5-methylcytosine levels, as well as increased dimethylation of histone H3 lysine 79 (H3K79).	Lysine	156-162	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	32-36
23778120-10	2013	At low micromolar concentrations, the post-translationally modified hypervariable region of K-Ras aggregates and binds calmodulin in a non-specific manner, hence conventional NMR techniques cannot be used for studying this interaction, however, upon reductively methylating the lysines of calmodulin, we detected signals of the lipidated hypervariable region of K-Ras at physiologically relevant nanomolar concentrations.	Lysine	278-285	calmodulin 1	Homo sapiens	119-129
23840386-2	2013	By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and Lys respectively) of the human mast cell chymase are responsible for an acidic amino acid residue preference in the P2" position of substrates.	Lysine	113-116	chymase 1	Homo sapiens	154-161
23576563-2	2013	p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage.	Lysine	21-27	tumor protein p53	Homo sapiens	0-3
23654226-2	2013	FAAH carries an unusual catalytic triad consisting of Lys-Ser-Ser, which uniquely enables the enzyme to cleave amides and esters at similar rates.	Lysine	54-57	fatty acid amide hydrolase	Homo sapiens	0-4
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	90-96	proteasome activator subunit 3	Homo sapiens	49-57
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	90-96	CREB binding protein	Homo sapiens	122-142
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	90-96	CREB binding protein	Homo sapiens	144-147
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	102-105	proteasome activator subunit 3	Homo sapiens	49-57
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	102-105	CREB binding protein	Homo sapiens	122-142
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	102-105	CREB binding protein	Homo sapiens	144-147
23612972-5	2013	Site-directed mutagenesis abrogated acetylation at Lys-195 and significantly attenuated the capability of REGgamma to degrade its target substrates, p21 and hepatitis C virus core protein.	Lysine	51-54	proteasome activator subunit 3	Homo sapiens	106-114
23612972-6	2013	Mechanistically, acetylation at Lys-195 is important for the interactions between REGgamma monomers and ultimately influences REGgamma heptamerization.	Lysine	32-35	proteasome activator subunit 3	Homo sapiens	82-90
23612972-6	2013	Mechanistically, acetylation at Lys-195 is important for the interactions between REGgamma monomers and ultimately influences REGgamma heptamerization.	Lysine	32-35	proteasome activator subunit 3	Homo sapiens	126-134
23764001-3	2013	Among several EMT-relevant genes, Sox4 directly regulates the expression of Ezh2, encoding the Polycomb group histone methyltransferase that trimethylates histone 3 lysine 27 (H3K27me3) for gene repression.	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	76-80
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	tet methylcytosine dioxygenase 3	Homo sapiens	211-215
22797064-4	2013	Knockdown experiments showed that, in metastatic PCa cell lines, dimethylation of lysine 36 and trimethylation of lysine 27 on histone H3 (H3K36me2 and H3K27me3, respectively) depended on MMSET expression, whereas depletion of MMSET in benign prostatic cells did not affect chromatin modifications.	Lysine	82-88	nuclear receptor binding SET domain protein 2	Homo sapiens	188-193
22797064-4	2013	Knockdown experiments showed that, in metastatic PCa cell lines, dimethylation of lysine 36 and trimethylation of lysine 27 on histone H3 (H3K36me2 and H3K27me3, respectively) depended on MMSET expression, whereas depletion of MMSET in benign prostatic cells did not affect chromatin modifications.	Lysine	82-88	nuclear receptor binding SET domain protein 2	Homo sapiens	227-232
23454085-0	2013	Apolipoprotein A-I binding to anionic vesicles and lipopolysaccharides: role for lysine residues in antimicrobial properties.	Lysine	81-87	apolipoprotein A1	Homo sapiens	0-18
23454085-5	2013	Lysine side chains of apoA-I were acetylated to evaluate the importance of electrostatic forces in the binding interaction with both membrane components.	Lysine	0-6	apolipoprotein A1	Homo sapiens	22-28
23454085-8	2013	These results indicate the potential for apoA-I to function as an antimicrobial protein and exerts this function through lysine residues.	Lysine	121-127	apolipoprotein A1	Homo sapiens	41-47
23518200-3	2013	METHODS: The present study examines the in vitro and in vivo biological actions of a novel, acylated GIP analogue, (d-Ala(2))GIP[Lys(37)PAL].	Lysine	129-132	gastric inhibitory polypeptide	Mus musculus	101-104
23518200-3	2013	METHODS: The present study examines the in vitro and in vivo biological actions of a novel, acylated GIP analogue, (d-Ala(2))GIP[Lys(37)PAL].	Lysine	129-132	gastric inhibitory polypeptide	Mus musculus	125-128
23518200-4	2013	RESULTS: In BRIN-BD11 cells, (d-Ala(2))GIP[Lys(37)PAL] concentration-dependently stimulated (p&lt;0.05 to p&lt;0.001) insulin secretion at 5.6 and 16.7mM glucose.	Lysine	43-46	gastric inhibitory polypeptide	Rattus norvegicus	39-42
23518200-5	2013	Intraperitoneal administration of (d-Ala(2))GIP[Lys(37)PAL] to normal mice 8h prior to a glucose load significantly reduced (p&lt;0.05) the overall glycaemic excursion compared to controls, and increased (p&lt;0.001) the insulinotropic response compared to (d-Ala(2))GIP and saline treated high fat control mice.	Lysine	48-51	gastric inhibitory polypeptide	Mus musculus	44-47
23518200-6	2013	Once daily administration of (d-Ala(2))GIP[Lys(37)PAL] for 21days in high fat fed mice did not affect energy intake, body weight or fat deposition.	Lysine	43-46	gastric inhibitory polypeptide	Mus musculus	39-42
23518200-8	2013	In addition, (d-Ala(2))GIP[Lys(37)PAL] treatment significantly (p&lt;0.01) reduced the overall glycaemic excursion and increased pancreatic insulin content (p&lt;0.05) and the insulinotropic response (p&lt;0.01) to an exogenous glucose challenge on day 21.	Lysine	27-30	gastric inhibitory polypeptide	Mus musculus	23-26
23518200-9	2013	Chronic treatment with (d-Ala(2))GIP[Lys(37)PAL] did not result in resistance to the metabolic effects of a bolus injection of native GIP.	Lysine	37-40	gastric inhibitory polypeptide	Mus musculus	33-36
23518200-10	2013	Finally, insulin sensitivity was significantly improved (p&lt;0.001) in (d-Ala(2))GIP[Lys(37)PAL] treated mice compared to high fat controls.	Lysine	86-89	gastric inhibitory polypeptide	Mus musculus	82-85
23518200-11	2013	CONCLUSIONS: These data confirm that (d-Ala(2))GIP[Lys(37)PAL] is a stable, long-acting potent GIP agonist.	Lysine	51-54	gastric inhibitory polypeptide	Mus musculus	47-50
23518200-11	2013	CONCLUSIONS: These data confirm that (d-Ala(2))GIP[Lys(37)PAL] is a stable, long-acting potent GIP agonist.	Lysine	51-54	gastric inhibitory polypeptide	Mus musculus	95-98
23478035-1	2013	We have developed a nanovector consisting of hyaluronic acid (HA) and poly-L-lysine-graft-imidazole (PLI)-based polyplexes containing Bcl-xL-specific shRNA-encoding plasmid DNA (HA/PLI/pDNA) for CD44 targeted gastric cancer therapy.	Lysine	70-83	BCL2 like 1	Homo sapiens	134-140
23479450-4	2013	Cytochrome c (cyt c) specifically binds to CX by incorporation of the amino groups of lysine residues at the protein surface.	Lysine	86-92	cytochrome c, somatic	Homo sapiens	0-12
23615279-6	2013	Differentiating neurons generated from Rb(-/-); p107(-/-); p130(-/-) (Rb-TKO) progenitors, but not acutely inactivated Rb-TKO differentiating neurons, activated the DNA double-strand break (DSB) repair pathway without increasing trimethylation at lysine 20 of histone H4 (H4K20), which has a role in protection against DNA damage.	Lysine	247-253	nucleolar and coiled-body phosphoprotein 1	Mus musculus	59-63
23518200-12	2013	GENERAL SIGNIFICANCE: (d-Ala(2))GIP[Lys(37)PAL] may be suitable for further evaluation and future clinical development.	Lysine	36-39	gastric inhibitory polypeptide	Mus musculus	32-35
23479450-4	2013	Cytochrome c (cyt c) specifically binds to CX by incorporation of the amino groups of lysine residues at the protein surface.	Lysine	86-92	cytochrome c, somatic	Homo sapiens	14-19
23741493-3	2013	Glycation of lipid-free apoA-I by methylglyoxal and glycolaldehyde resulted in Arg, Lys and Trp loss, advanced glycation end-product formation and protein cross-linking.	Lysine	84-87	apolipoprotein A1	Homo sapiens	24-30
23547170-4	2013	Here, we used chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) to measure genome-wide changes in histone H3 acetylation at lysine 27 (H3K27ac), a marker of active enhancers, in unstimulated HUVECs and HUVECs stimulated with VEGFA for 1, 4, and 12 h. We show that sites with the greatest H3K27ac change upon stimulation were associated tightly with EP300, a histone acetyltransferase.	Lysine	154-160	vascular endothelial growth factor A	Homo sapiens	255-260
23616576-9	2013	Collectively, these data show that Lys-313 in the T-box domain is essential for controlling T-bet protein stability via ubiquitin-dependent degradation, T-bet binding to the IFN-gamma promoter, and for the interaction with and suppression of NFAT1.	Lysine	35-38	interferon gamma	Homo sapiens	174-183
23809134-3	2013	This positive feedback mechanism is regulated by activated thrombin activatable fibrinolysis inhibitor (TAFIa), which cleaves C-terminal lysine residues from the fibrin surface, thereby decreasing its cofactor activity.	Lysine	137-143	coagulation factor II, thrombin	Homo sapiens	59-67
23384557-0	2013	The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.	Lysine	4-10	vascular endothelial growth factor A	Homo sapiens	57-63
23629834-5	2013	Substitution of a conserved arginine to lysine in the first beta-strand of ERF189 relaxes its interaction with the second GC pair of the GCC DNA sequence.	Lysine	40-46	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	75-81
23535360-7	2013	Results showed that most chemical sensitizers having cysteine and cysteine/lysine affinities were inducers of the Nrf2 pathway in both cell models, whereas lysine-reactive chemicals were less efficient.	Lysine	75-81	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
23508108-2	2013	The GR has three SUMOylation sites: lysine 297 (K297) and K313 in the N-terminal domain (NTD) and K721 within the ligand-binding domain.	Lysine	36-42	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-6
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Lysine	47-54	lysine demethylase 4B	Homo sapiens	21-26
23564455-3	2013	AIP4 is found to bind and ubiquitinate Amot130 at residue Lys-481.	Lysine	58-61	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
23611785-1	2013	Heterochromatin protein 1 (HP1) is an epigenetic gene silencing protein that is regulated by lysine 9 methylation of histone H3.	Lysine	93-99	Suppressor of variegation 205	Drosophila melanogaster	0-25
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Lysine	220-223	lysine demethylase 4B	Homo sapiens	21-26
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Lysine	220-223	lysine demethylase 4B	Homo sapiens	175-180
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Lysine	220-223	lysine demethylase 4B	Homo sapiens	175-180
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Lysine	232-235	lysine demethylase 4B	Homo sapiens	21-26
23611785-1	2013	Heterochromatin protein 1 (HP1) is an epigenetic gene silencing protein that is regulated by lysine 9 methylation of histone H3.	Lysine	93-99	Suppressor of variegation 205	Drosophila melanogaster	27-30
23706298-3	2013	PRC2 induces histone H3 lysine 27 (H3K27) trimethylation (H3K27me3), which is subsequently read by PRC1 that further catalyzes H2A monoubiquitination (H2Aub1), creating a transcriptional silent chromatin conformation.	Lysine	24-30	cellulose synthase 6	Arabidopsis thaliana	99-103
23519470-7	2013	We identified lysine 167 as a novel ubiquitination site of c-FLIP(L) important for ROS-dependent degradation.	Lysine	14-20	CASP8 and FADD like apoptosis regulator	Homo sapiens	59-65
23696846-5	2013	We found that mouse p53b, but not p53a, could be SUMOylated by SUMO-1 at lysine 375, which was essential for the protein stability of p53b in a dose-dependent manner.	Lysine	73-79	small ubiquitin-like modifier 1	Mus musculus	63-69
23696846-9	2013	Our results provide strong evidences that modification of p53b by SUMO-1 at lysine 375 was necessary for its activity to induce apoptosis in mouse granulosa cells, and it was involved in the regulation of p53b protein stability and nuclear localization.	Lysine	76-82	small ubiquitin-like modifier 1	Mus musculus	66-72
23674823-5	2013	USP25 specifically reversed the Lys(48)-linked ubiquitination of TRAF3 that was mediated by the E3 ubiquitin ligase cIAP2 (cellular inhibitor of apoptosis 2).	Lysine	32-35	ubiquitin specific peptidase 25	Mus musculus	0-5
23583237-4	2013	Here we demonstrate that MYBBP1A interacts with lysine residues in the C-terminal regulatory domain region of p53.	Lysine	48-54	MYB binding protein 1a	Homo sapiens	25-32
23583237-4	2013	Here we demonstrate that MYBBP1A interacts with lysine residues in the C-terminal regulatory domain region of p53.	Lysine	48-54	tumor protein p53	Homo sapiens	110-113
23416211-1	2013	The effects of a snake venom Lys-49 phospholipase A2 (PLA2) homolog named MT-II, devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2 (COX-2) and signaling pathways involved were evaluated in mouse macrophages in culture and in peritoneal cells ex vivo.	Lysine	29-32	metallothionein 2	Mus musculus	74-79
23570854-0	2013	Study of interactions between oppositely charged dendrigraft poly-L-lysine and human serum albumin by continuous frontal analysis capillary electrophoresis and fluorescence spectroscopy.	Lysine	61-74	albumin	Homo sapiens	85-98
23519470-9	2013	The mutation of either Thr-166 or Lys-167 was sufficient to stabilize c-FLIP protein levels in PPC-1, HEK293T, and HeLa cancer cells treated with menadione or paraquat.	Lysine	34-37	CASP8 and FADD like apoptosis regulator	Homo sapiens	70-76
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	206-212	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	9-13
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	206-212	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	306-310
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	333-339	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	9-13
23253155-5	2013	Replacing the lysine at the luminal membrane border (K28) with glutamic acid (K28E) increased Abeta37 and reduced Abeta42 production.	Lysine	14-20	keratin 28	Homo sapiens	53-56
23395841-9	2013	Expression of the STIM1(D76A) or STIM1(K684,685E) mutants reduced store-operated divalent cation entry and resulted in loss of dependence on the extracellular Ca(2+) concentration, providing evidence for a functional role of plasma membrane-resident STIM1 in the regulation of store-operated divalent cation entry, which at least involves the EF-hand motif and the C-terminal polybasic lysine-rich domain.	Lysine	386-392	stromal interaction molecule 1	Homo sapiens	18-23
23395841-9	2013	Expression of the STIM1(D76A) or STIM1(K684,685E) mutants reduced store-operated divalent cation entry and resulted in loss of dependence on the extracellular Ca(2+) concentration, providing evidence for a functional role of plasma membrane-resident STIM1 in the regulation of store-operated divalent cation entry, which at least involves the EF-hand motif and the C-terminal polybasic lysine-rich domain.	Lysine	386-392	stromal interaction molecule 1	Homo sapiens	33-38
23395841-9	2013	Expression of the STIM1(D76A) or STIM1(K684,685E) mutants reduced store-operated divalent cation entry and resulted in loss of dependence on the extracellular Ca(2+) concentration, providing evidence for a functional role of plasma membrane-resident STIM1 in the regulation of store-operated divalent cation entry, which at least involves the EF-hand motif and the C-terminal polybasic lysine-rich domain.	Lysine	386-392	stromal interaction molecule 1	Homo sapiens	33-38
23651858-5	2013	To dissect the mode of transcriptional regulation by RBPJ and identify its direct targets, whole-genome binding profiles were generated for RBPJ; its coactivator, p300; NICD; and the histone H3 modifications H3 Lys 4 trimethylation (H3K4me3), H3 Lys 4 monomethylation (H3K4me1), and histone H3 Lys 27 acetylation (H3K27ac) in myogenic cells under active or inhibitory Notch signaling conditions.	Lysine	211-214	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	53-57
23395841-0	2013	The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium.	Lysine	14-20	stromal interaction molecule 1	Homo sapiens	61-66
23523103-4	2013	Here, we show that LDH-A is acetylated at lysine 5 (K5) and that this acetylation inhibits LDH-A activity.	Lysine	42-48	lactate dehydrogenase A	Homo sapiens	19-24
23462506-0	2013	Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation.	Lysine	40-46	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	86-96
23462506-1	2013	Base amino acid lysine residues play an important role in regulation of nuclear receptors [e.g., farnesyl X receptor (FXR)], leading to enhanced or suppressed biologic activity.	Lysine	16-22	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	106-116
23550162-6	2013	This is supported by site-directed mutagenesis, which identifies two highly conserved, surface-exposed lysine residues in this region of the trimer that are essential for binding, thus revealing structural parallels with the interactions of Complement C1r/C1s, Uegf, BMP-1 (CUB) domain-containing proteins in diverse biological systems such as complement activation, receptor signaling, and transport.	Lysine	103-109	complement C1r	Homo sapiens	241-255
23550162-6	2013	This is supported by site-directed mutagenesis, which identifies two highly conserved, surface-exposed lysine residues in this region of the trimer that are essential for binding, thus revealing structural parallels with the interactions of Complement C1r/C1s, Uegf, BMP-1 (CUB) domain-containing proteins in diverse biological systems such as complement activation, receptor signaling, and transport.	Lysine	103-109	complement C1s	Homo sapiens	256-259
23576753-3	2013	Here, we use a rigorous label-free quantitative MS approach (called MS1 Filtering) to analyze changes in lysine acetylation from mouse liver mitochondria in the absence of SIRT3.	Lysine	105-111	muscle size 1	Mus musculus	68-71
23576753-5	2013	MS1 Filtering revealed that lysine acetylation of 283 sites in 136 proteins was significantly increased in the absence of SIRT3 (at least twofold).	Lysine	28-34	muscle size 1	Mus musculus	0-3
23580576-3	2013	Although menin acts as an oncogenic cofactor for mixed lineage leukemia (MLL) fusion protein-mediated histone H3 lysine 4 methylation, the precise basis for how menin suppresses gene expression and proliferation of pancreatic beta cells remains poorly understood.	Lysine	113-119	multiple endocrine neoplasia 1	Mus musculus	9-14
23580576-3	2013	Although menin acts as an oncogenic cofactor for mixed lineage leukemia (MLL) fusion protein-mediated histone H3 lysine 4 methylation, the precise basis for how menin suppresses gene expression and proliferation of pancreatic beta cells remains poorly understood.	Lysine	113-119	lysine (K)-specific methyltransferase 2A	Mus musculus	73-76
23571759-6	2013	We identify lysine 301 as the major conjugation site and demonstrate that its replacement with arginine completely abolishes Lif1 SUMOylation in vivo and in vitro.	Lysine	12-18	Lif1p	Saccharomyces cerevisiae S288C	125-129
23576758-6	2013	We show that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is required for full developmental silencing of mouse embryonic beta-like globin genes and human gamma-globin genes in adult erythroid cells in vivo.	Lysine	17-23	lysine (K)-specific demethylase 1A	Mus musculus	117-121
23422691-8	2013	Furthermore, substitution of asparagine at the VEGF glycosylation site with lysine or glutamic acid increased secretion of non-glycosylated VEGF, a finding not previously reported.	Lysine	76-82	vascular endothelial growth factor A	Homo sapiens	47-51
23422691-8	2013	Furthermore, substitution of asparagine at the VEGF glycosylation site with lysine or glutamic acid increased secretion of non-glycosylated VEGF, a finding not previously reported.	Lysine	76-82	vascular endothelial growth factor A	Homo sapiens	140-144
23523103-4	2013	Here, we show that LDH-A is acetylated at lysine 5 (K5) and that this acetylation inhibits LDH-A activity.	Lysine	42-48	lactate dehydrogenase A	Homo sapiens	91-96
23318957-12	2013	Our data indicate that internal lysines are the dominant Ub acceptor sites in both A3F and A3G.	Lysine	32-39	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	91-94
23318957-13	2013	In contrast with the proposed antiparallel model, however, we find that the Vif-dependent polyUb of A3F and A3G can occur at multiple acceptor sites dispersed along predicted lysine-enriched surfaces of both the N- and C-terminal deaminase domains.	Lysine	175-181	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	108-111
23575112-13	2013	A "hot spot" of interaction between HLA-DRB1*03:01 and PS 120 is located at the P4 binding pocket, and is represented by a salt bridge involving Lys at position 71 of the HLA protein, and Glu 795 of PS120 peptide.	Lysine	145-148	major histocompatibility complex, class II, DR beta 1	Homo sapiens	36-44
23579270-0	2013	Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.	Lysine	52-58	menin 1	Homo sapiens	0-5
23586588-5	2013	These analyses showed that the accumulation of some lysine-rich proteins, such as sorbitol dehydrogenase and glyceraldehyde3-phosphate dehydrogenase, was increased in mature kernels and may contribute substantially to the lysine content of opaque2 endosperm.	Lysine	52-58	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	Zea mays	109-148
23575112-13	2013	A "hot spot" of interaction between HLA-DRB1*03:01 and PS 120 is located at the P4 binding pocket, and is represented by a salt bridge involving Lys at position 71 of the HLA protein, and Glu 795 of PS120 peptide.	Lysine	145-148	major histocompatibility complex, class II, DR beta 1	Homo sapiens	36-39
23238566-2	2013	Here, utilizing mass-spectrometry analysis and site-specific acetyl-p21 antibody, two lysine residues of p21, located at amino-acid sites 161 and 163, were identified as Tip60-mediated acetylation targets for the first time.	Lysine	86-92	cyclin dependent kinase inhibitor 1A	Homo sapiens	105-108
23559011-7	2013	We also found lysine residue 195 (K195) to be essential for c-FLIP(L) ubiquitination and proteolysis, as mutant c-FLIP(L) lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia.	Lysine	14-20	CASP8 and FADD like apoptosis regulator	Homo sapiens	60-66
23559011-7	2013	We also found lysine residue 195 (K195) to be essential for c-FLIP(L) ubiquitination and proteolysis, as mutant c-FLIP(L) lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia.	Lysine	122-128	CASP8 and FADD like apoptosis regulator	Homo sapiens	112-118
23409774-3	2013	Elevated EZH2 expression levels have been linked to hypertrimethylation of histone H3 lysine 27 (H3K27), repression of tumor repressor genes, and the onset of several types of cancers.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	9-13
23434580-2	2013	Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and dysregulation of target genes.	Lysine	183-189	AKT serine/threonine kinase 1	Homo sapiens	19-22
23434580-2	2013	Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and dysregulation of target genes.	Lysine	183-189	CREB binding protein	Homo sapiens	38-41
23434580-2	2013	Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and dysregulation of target genes.	Lysine	183-189	CREB binding protein	Homo sapiens	133-136
23509280-1	2013	Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability.	Lysine	100-106	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-39
23509280-1	2013	Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability.	Lysine	100-106	SUV39H1 histone lysine methyltransferase	Homo sapiens	41-48
23509280-5	2013	Western blot using antibodies specific for antimethylated SUV39H1 and mass spectrometry demonstrated that SUV39H1 was specifically methylated at lysines 105 and 123 by SET7/9.	Lysine	145-152	SUV39H1 histone lysine methyltransferase	Homo sapiens	58-65
23509280-5	2013	Western blot using antibodies specific for antimethylated SUV39H1 and mass spectrometry demonstrated that SUV39H1 was specifically methylated at lysines 105 and 123 by SET7/9.	Lysine	145-152	SUV39H1 histone lysine methyltransferase	Homo sapiens	106-113
23238566-2	2013	Here, utilizing mass-spectrometry analysis and site-specific acetyl-p21 antibody, two lysine residues of p21, located at amino-acid sites 161 and 163, were identified as Tip60-mediated acetylation targets for the first time.	Lysine	86-92	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-71
23360797-2	2013	Enhancer of zeste homolog 2 (EZH2), which silences gene expression through generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3), is often overexpressed in EOCs and has been suggested as a therapeutic target.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
23455484-0	2013	Mechanistic insights into the superoxide-cytochrome c reaction by lysine surface scanning.	Lysine	66-72	cytochrome c, somatic	Homo sapiens	41-53
23455484-3	2013	Here lysine mutagenesis of the distal surface (i.e., of exposed residues around the Met80 axial ligand) of human cytochrome c was pursued to evaluate the effect of the surface charges on the reaction rate with the superoxide anion radical and on the redox properties of the heme protein.	Lysine	5-11	cytochrome c, somatic	Homo sapiens	113-125
23322406-7	2013	Subsequently, the ubiquitination of CARMA1 catalyzed by STUB1 was identified as Lys-27 linked, which is important for CARMA1-mediated NF-kappaB activation.	Lysine	80-83	caspase recruitment domain family member 11	Homo sapiens	36-42
23322406-7	2013	Subsequently, the ubiquitination of CARMA1 catalyzed by STUB1 was identified as Lys-27 linked, which is important for CARMA1-mediated NF-kappaB activation.	Lysine	80-83	caspase recruitment domain family member 11	Homo sapiens	118-124
23391216-5	2013	Moreover, we noted the alterations of histone modifications including decreased histone H3 acetylation, increased H4 (Lys-20) trimethylation at the Foxa2 CpG islands in the promoter in replicative or premature senescence, while decreased histone H3 (Lys-4) trimethylation across the transcription start regions in cellular senescence.	Lysine	118-121	forkhead box A2	Homo sapiens	148-153
23391216-5	2013	Moreover, we noted the alterations of histone modifications including decreased histone H3 acetylation, increased H4 (Lys-20) trimethylation at the Foxa2 CpG islands in the promoter in replicative or premature senescence, while decreased histone H3 (Lys-4) trimethylation across the transcription start regions in cellular senescence.	Lysine	250-253	forkhead box A2	Homo sapiens	148-153
23391216-6	2013	Taken together, epigenetic silencing of Foxa2 is associated with an increased DNA methylation level and histone H4 (Lys-20) trimethylation, decreased histone H3 acetylation and histone H3 (Lys-4) trimethylation, involved in cellular replicative or premature senescence.	Lysine	116-119	forkhead box A2	Homo sapiens	40-45
23391216-6	2013	Taken together, epigenetic silencing of Foxa2 is associated with an increased DNA methylation level and histone H4 (Lys-20) trimethylation, decreased histone H3 acetylation and histone H3 (Lys-4) trimethylation, involved in cellular replicative or premature senescence.	Lysine	189-192	forkhead box A2	Homo sapiens	40-45
23255161-8	2013	Our results strongly suggest that ITCH interacts with mutant GCase variants and mediates their lysine 48 polyubiquitination and degradation.	Lysine	95-101	itchy E3 ubiquitin protein ligase	Homo sapiens	34-38
23172686-4	2013	In osteoclasts, lack of SirT1 promoted osteoclastogenesis in vitro and activated NF-kappaB by increasing acetylation of Lysine 310.	Lysine	120-126	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
23416275-1	2013	Acetylation of C-terminal lysine residues in the p53 tumor suppressor is associated with increased stability and transcription factor activity.	Lysine	26-32	tumor protein p53	Homo sapiens	49-52
23416275-3	2013	Here, we show that p14(ARF) increases the level of p53 acetylated at lysine 382 in a nuclear chromatin-rich fraction.	Lysine	69-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	19-22
23360797-2	2013	Enhancer of zeste homolog 2 (EZH2), which silences gene expression through generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3), is often overexpressed in EOCs and has been suggested as a therapeutic target.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
23416275-3	2013	Here, we show that p14(ARF) increases the level of p53 acetylated at lysine 382 in a nuclear chromatin-rich fraction.	Lysine	69-75	tumor protein p53	Homo sapiens	51-54
23421989-7	2013	MR acetylation was determined by Western blot with anti-acetyl-lysine antibody after immunoprecipitation with anti-MR antibody.	Lysine	63-69	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	0-2
23499448-4	2013	We show that the deubiquitylating enzyme UCH-L1 is a key regulator of NOXA turnover, which protects NOXA from proteasomal degradation by removing Lys(48)-linked polyubiquitin chains.	Lysine	146-149	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	70-74
23361907-4	2013	Using gene-expression analysis and genome-wide chromatin immunoprecipitation studies followed by next generation sequencing, we found that MLL-fusion target genes display markedly high levels of histone 3 at lysine 79 (H3K79) dimethylation in murine MLL-AF6 leukemias as well as in ML2, a human myelomonocytic leukemia cell line bearing the t(6;11)(q27;q23) translocation.	Lysine	208-214	lysine (K)-specific methyltransferase 2A	Mus musculus	139-142
23416304-4	2013	A tiny covalent perturbation consisting in reversal of Pro(B28)-Lys(B29) residues in a human insulin analog is sufficient to prevent this process.	Lysine	64-67	insulin	Homo sapiens	93-100
23493553-6	2013	This investigation has also led to the identification of critical residues involved in the protein-protein interactions necessary for the dimerization of ABCG2: Lys-473 (K473) and Phe-142 (F142).	Lysine	161-164	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	154-159
23499448-4	2013	We show that the deubiquitylating enzyme UCH-L1 is a key regulator of NOXA turnover, which protects NOXA from proteasomal degradation by removing Lys(48)-linked polyubiquitin chains.	Lysine	146-149	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	100-104
23460697-0	2013	Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds.	Lysine	50-56	actin	Saccharomyces cerevisiae S288C	0-5
23460697-4	2013	Steered molecular dynamics simulations reveal force-induced formation of new interactions that include a lysine 113(K113):glutamic acid 195 (E195) salt bridge between actin subunits, thus suggesting a molecular basis for actin catch-slip bonds.	Lysine	105-111	actin	Saccharomyces cerevisiae S288C	167-172
23460697-4	2013	Steered molecular dynamics simulations reveal force-induced formation of new interactions that include a lysine 113(K113):glutamic acid 195 (E195) salt bridge between actin subunits, thus suggesting a molecular basis for actin catch-slip bonds.	Lysine	105-111	actin	Saccharomyces cerevisiae S288C	221-226
23494175-1	2013	EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2), which generates a methylation epigenetic mark at lysine 27 residue of histone H3 (H3K27me3) to silence gene expression.	Lysine	120-126	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
23305736-5	2013	Treatment of HPCs with an inhibitory TF antibody or a cell-impermeable lysine-conjugating reagent prior to lysis substantially reduced TF activity, suggesting that TF was mainly present on the cell surface.	Lysine	71-77	coagulation factor III	Mus musculus	135-137
23305736-5	2013	Treatment of HPCs with an inhibitory TF antibody or a cell-impermeable lysine-conjugating reagent prior to lysis substantially reduced TF activity, suggesting that TF was mainly present on the cell surface.	Lysine	71-77	coagulation factor III	Mus musculus	135-137
23467560-3	2013	The proportion of serum albumin carbamylated on Lys(549) (%C-Alb) correlated with time-averaged blood urea concentrations and was twice as high in ESRD patients than in non-uremic subjects (0.90% versus 0.42%).	Lysine	48-51	albumin	Homo sapiens	61-64
23335559-5	2013	Here, we show through site-directed mutagenesis that ubiquitination of CAV1 occurs at any of the six lysine residues, 5, 26, 30, 39, 47, and 57, that are clustered in the N-terminal region but not at lysines in the oligomerization, intramembrane, or C-terminal domains.	Lysine	101-107	caveolin 1	Homo sapiens	71-75
23335559-5	2013	Here, we show through site-directed mutagenesis that ubiquitination of CAV1 occurs at any of the six lysine residues, 5, 26, 30, 39, 47, and 57, that are clustered in the N-terminal region but not at lysines in the oligomerization, intramembrane, or C-terminal domains.	Lysine	200-207	caveolin 1	Homo sapiens	71-75
23467560-7	2013	In vitro studies showed that amino acids such as cysteine, histidine, arginine, and lysine, as well as other nucleophiles such as taurine, inhibited cyanate-induced C-Alb formation at physiologic pH and temperature.	Lysine	84-90	albumin	Homo sapiens	167-170
23123190-6	2013	Mutation of the downstream lysine cluster markedly reduces the H(2)O(2)-induced ASK1-karyopherin alpha2/beta1 interaction and inhibits ASK1 nuclear translocation.	Lysine	27-33	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	104-109
23412334-2	2013	As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L.	Lysine	146-152	DOT1 like histone lysine methyltransferase	Homo sapiens	182-187
23104140-9	2013	We also showed that MARCH7 catalyzes lysine 48 (K48)-linked ubiquitination.	Lysine	37-43	membrane associated ring-CH-type finger 7	Rattus norvegicus	20-26
22986503-3	2013	provided proof of concept by identifying chemical matters that inhibit demethylation mediated by the two related histone H3 lysine 27 demethylases, KDM6A and 6B (UTX and JMJD3).	Lysine	124-130	lysine demethylase 6A	Homo sapiens	148-160
22986503-3	2013	provided proof of concept by identifying chemical matters that inhibit demethylation mediated by the two related histone H3 lysine 27 demethylases, KDM6A and 6B (UTX and JMJD3).	Lysine	124-130	lysine demethylase 6A	Homo sapiens	162-165
23353785-4	2013	We also demonstrate specifically that marked increases in histone H3 acetylation and H3 lysine 4 trimethylation occur at the IL-4 loci in these patients.	Lysine	88-94	interleukin 4	Homo sapiens	125-129
23389956-7	2013	Fetuses exposed to sGC in late gestation exhibited substantial differences in DNA methylation and histone h3 lysine 9 (H3K9) acetylation in specific gene promoters; 24 hours after the sGC treatment, the majority of genes affected were hypomethylated or hyperacetylated.	Lysine	109-115	sarcoglycan beta	Homo sapiens	19-22
23301636-4	2013	METHODS: We produced original t-PA-related mutants, including a non-cleavable single-chain form with restored zymogenicity (sc*-t-PA) and a t-PA modified in the kringle 2 lysine-binding site (K2*-t-PA).	Lysine	171-177	plasminogen activator, tissue type	Homo sapiens	30-34
23425695-8	2013	Exogenous Tgm2 initiated lacritin cross-linking within 1 minute and was complete by 90 minutes-even with as little as 0.1 nM lacritin, and involved the donors lysine 82 and 85 and the acceptor glutamine 106 in the syndecan-1 binding domain.	Lysine	159-165	transglutaminase 2	Homo sapiens	10-14
23322770-4	2013	Here we report a dynamic, post-translational regulation of its kinase activity that is coordinated by an acetylation-deacetylation switch, p300/CBP-mediated Lys-53 acetylation inhibits SIK2 kinase activity, whereas HDAC6-mediated deacetylation restores the activity.	Lysine	157-160	CREB binding protein	Homo sapiens	144-147
23322770-4	2013	Here we report a dynamic, post-translational regulation of its kinase activity that is coordinated by an acetylation-deacetylation switch, p300/CBP-mediated Lys-53 acetylation inhibits SIK2 kinase activity, whereas HDAC6-mediated deacetylation restores the activity.	Lysine	157-160	salt inducible kinase 2	Homo sapiens	185-189
23322770-4	2013	Here we report a dynamic, post-translational regulation of its kinase activity that is coordinated by an acetylation-deacetylation switch, p300/CBP-mediated Lys-53 acetylation inhibits SIK2 kinase activity, whereas HDAC6-mediated deacetylation restores the activity.	Lysine	157-160	histone deacetylase 6	Homo sapiens	215-220
22833338-5	2013	Concomitantly, however, treatments at both concentration ranges resulted in a marked increase in K373-acetylated p53 and lysine-acetylated FOXO3a.	Lysine	121-127	forkhead box O3	Homo sapiens	139-145
23224434-5	2013	Furthermore, menin could repress p65 acetylation through recruitment of Sirt1, an enzyme that deacetylases p65 in lysine 310 (K310).	Lysine	114-120	menin 1	Homo sapiens	13-18
23329373-1	2013	Lysine biosynthesis in plants is tightly regulated by feedback inhibition of the end product on the first enzyme of the lysine-specific branch, dihydrodipicolinate synthase (DHDPS).	Lysine	0-6	dihydrodipicolinate synthase 1	Arabidopsis thaliana	174-179
23329373-1	2013	Lysine biosynthesis in plants is tightly regulated by feedback inhibition of the end product on the first enzyme of the lysine-specific branch, dihydrodipicolinate synthase (DHDPS).	Lysine	120-126	dihydrodipicolinate synthase 1	Arabidopsis thaliana	174-179
23327477-7	2013	To further examine the role of lysine, a lysine-free ADK variant was rationally designed.	Lysine	41-47	adenosine kinase	Homo sapiens	53-56
23448518-7	2013	We find that EZH2beta localizes to the cell nucleus, complexes with embryonic ectoderm development and suppressor of zeste 12, trimethylates histone 3 at lysine 27, and mediates silencing of target promoters.	Lysine	154-160	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-21
23448518-10	2013	CONCLUSIONS: Combined, these results demonstrate that an expanded repertoire of EZH2 writers can modulate histone code instruction during histone 3 lysine 27-mediated gene silencing.	Lysine	148-154	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	80-84
23341599-3	2013	To explore reversible lysine acetylation that is dependent on the clock, we have characterized the circadian acetylome in WT and Clock-deficient (Clock(-/-)) mouse liver by quantitative mass spectrometry.	Lysine	22-28	circadian locomotor output cycles kaput	Mus musculus	66-71
23426673-7	2013	Our data demonstrates that KMT2B mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.	Lysine	64-70	lysine (K)-specific methyltransferase 2B	Mus musculus	27-32
23360761-3	2013	We have recently found that ubiquilin-1 regulates APP trafficking and subsequent secretase processing by stimulating non-degradative ubiquitination of a single lysine residue in the cytosolic domain of APP.	Lysine	160-166	ubiquilin 1	Homo sapiens	28-39
23401512-3	2013	In this method, Abeta is labeled with tetramethylrhodamine at a lysine residue on the N-terminal end.	Lysine	64-70	amyloid beta precursor protein	Homo sapiens	16-21
23288844-0	2013	Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.	Lysine	27-33	solute carrier family 6 member 4	Homo sapiens	68-89
23288844-0	2013	Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.	Lysine	27-33	SEC24 homolog C, COPII coat complex component	Homo sapiens	157-163
22815158-6	2013	Activation of p53 by FK866 involved increased acetylation of p53 at lysine 382 with subsequent increase in the expression of p21 and BAX.	Lysine	68-74	tumor protein p53	Homo sapiens	14-17
22815158-6	2013	Activation of p53 by FK866 involved increased acetylation of p53 at lysine 382 with subsequent increase in the expression of p21 and BAX.	Lysine	68-74	tumor protein p53	Homo sapiens	61-64
22815158-6	2013	Activation of p53 by FK866 involved increased acetylation of p53 at lysine 382 with subsequent increase in the expression of p21 and BAX.	Lysine	68-74	BCL2 associated X, apoptosis regulator	Homo sapiens	133-136
23291096-5	2013	We observe distinct chromatin influences, including a Set2/Rpd3-mediated antagonistic interaction between histone H3 lysine 36 trimethylation and the Rap1 transcriptional activation site in kanMX.	Lysine	117-123	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	59-63
22870827-1	2013	The cellular uptake of L-arginine and other cationic amino acids (such as L-lysine and L-ornithine) is mainly mediated by cationic amino acid transporter (CAT) proteins.	Lysine	74-82	catalase	Homo sapiens	155-158
23324626-0	2013	SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.	Lysine	29-35	H2A.Z variant histone 1	Mus musculus	21-25
22991213-3	2013	Suppressor of variegation 3-9 homolog 1 (SUV39H1), the prototype of histone methyltransferase, is the major enzyme responsible for histone H3 lysine 9 trimethylation, which, essentially, is involved in heterochromatin formation, chromosome segregation, and mitotic progression.	Lysine	142-148	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-39
22991213-3	2013	Suppressor of variegation 3-9 homolog 1 (SUV39H1), the prototype of histone methyltransferase, is the major enzyme responsible for histone H3 lysine 9 trimethylation, which, essentially, is involved in heterochromatin formation, chromosome segregation, and mitotic progression.	Lysine	142-148	SUV39H1 histone lysine methyltransferase	Homo sapiens	41-48
23400519-1	2013	SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression.	Lysine	23-29	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
23314172-4	2013	We show that dimethylation of lysine 4 of histone H3 (H3K4me2) at the MYH11 locus is restricted to the smooth muscle cell (SMC) lineage in human and mouse tissue sections and that the mark persists even in phenotypically modulated SMC in atherosclerotic lesions that show no detectable expression of SMC marker genes.	Lysine	30-36	myosin heavy chain 11	Homo sapiens	70-75
23273982-3	2013	Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3.	Lysine	31-37	PHD finger protein 19	Mus musculus	178-183
24900672-2	2013	MLL complexes, the trithorax-like family of SET1 methyltransferases, catalyze trimethylation of lysine 4 on histone 3, and they have been widely implicated in various cancers.	Lysine	96-102	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	44-48
23200923-9	2013	Substituting the lysine residues in the unique KK loop impaired the nucleic acid binding and altered FUS subcellular localization.	Lysine	17-23	FUS RNA binding protein	Homo sapiens	101-104
23293284-2	2013	We asked whether KAP1 (KRAB-associated protein 1) is involved in this mechanism because of its previously defined role in maintaining the silencing of ERVs through the histone methyltransferase ESET and histone H3 lysine 9 trimethylation.	Lysine	214-220	tripartite motif containing 28	Homo sapiens	17-21
23035012-7	2013	Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).	Lysine	111-114	sialic acid binding Ig like lectin 15	Homo sapiens	0-9
23386265-5	2013	Furthermore, we show that dissociated COI1 is degraded through the 26S proteasome pathway, and we identified the 297th Lys residue as an active ubiquitination site in COI1.	Lysine	119-122	RNI-like superfamily protein	Arabidopsis thaliana	38-42
23386265-5	2013	Furthermore, we show that dissociated COI1 is degraded through the 26S proteasome pathway, and we identified the 297th Lys residue as an active ubiquitination site in COI1.	Lysine	119-122	RNI-like superfamily protein	Arabidopsis thaliana	167-171
23067392-4	2013	Transport of DNA molecules complexed with poly-l-lysine was impaired in intact cells depleted of imp7, and DNA complexes remained localized in the cytoplasm.	Lysine	42-55	importin 7	Homo sapiens	97-101
23172226-0	2013	Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death.	Lysine	0-6	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	82-86
23223799-2	2013	Here, we investigated by NMR spectroscopy and quantum chemical calculations whether a Rhodamine B labelled peptoid [RhoB(Spiro)-Ahx]-[But](6A)NH(2) with lysine-like side chains adopts structural motifs similar to regular peptides.	Lysine	153-159	nuclear receptor subfamily 0 group B member 1	Homo sapiens	128-131
23172226-2	2013	In an effort to identify mechanisms that regulate MLK3 activity in beta cells, we discovered that IL-1beta stimulates Lys-63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase.	Lysine	118-121	interleukin 1 beta	Homo sapiens	98-106
23237229-2	2013	We prepared the lysine based Dap derivative l-Lys(Dap) in which the epsilon-NH(2) group was replaced by the tripod through conjugation to its alpha-carbon.	Lysine	16-22	death-associated protein	Mus musculus	29-32
23212909-7	2013	Mutation of seven lysines at the C-terminal region of Arkadia severely impairs ubiquitination through the K27 but not the K63 linkage and slows down the turnover of Arkadia, suggesting that K27-linked polyubiquitination might promote proteolysis-dependent regulation of Arkadia.	Lysine	18-25	ring finger protein 111	Homo sapiens	54-61
23212909-7	2013	Mutation of seven lysines at the C-terminal region of Arkadia severely impairs ubiquitination through the K27 but not the K63 linkage and slows down the turnover of Arkadia, suggesting that K27-linked polyubiquitination might promote proteolysis-dependent regulation of Arkadia.	Lysine	18-25	ring finger protein 111	Homo sapiens	165-172
23212909-7	2013	Mutation of seven lysines at the C-terminal region of Arkadia severely impairs ubiquitination through the K27 but not the K63 linkage and slows down the turnover of Arkadia, suggesting that K27-linked polyubiquitination might promote proteolysis-dependent regulation of Arkadia.	Lysine	18-25	ring finger protein 111	Homo sapiens	165-172
23237229-2	2013	We prepared the lysine based Dap derivative l-Lys(Dap) in which the epsilon-NH(2) group was replaced by the tripod through conjugation to its alpha-carbon.	Lysine	16-22	death-associated protein	Mus musculus	50-53
23237229-2	2013	We prepared the lysine based Dap derivative l-Lys(Dap) in which the epsilon-NH(2) group was replaced by the tripod through conjugation to its alpha-carbon.	Lysine	44-49	death-associated protein	Mus musculus	29-32
23237229-2	2013	We prepared the lysine based Dap derivative l-Lys(Dap) in which the epsilon-NH(2) group was replaced by the tripod through conjugation to its alpha-carbon.	Lysine	44-49	death-associated protein	Mus musculus	50-53
23237229-5	2013	Fmoc-l-Lys(Dap(Boc)) was either conjugated to the N- and C-terminus of bombesin BBN(7-14) or integrated into the sequence using solid-phase peptide synthesis (SPPS).	Lysine	4-10	death-associated protein	Mus musculus	11-14
23237229-6	2013	We also replaced the native lysine in a cyclic RGD peptide with l-Lys(Dap).	Lysine	28-34	death-associated protein	Mus musculus	70-73
23237229-6	2013	We also replaced the native lysine in a cyclic RGD peptide with l-Lys(Dap).	Lysine	64-69	death-associated protein	Mus musculus	70-73
23237229-12	2013	Altogether, orthogonally protected l-Lys(Dap) represents a highly versatile building block for integration in any peptide sequence.	Lysine	35-40	death-associated protein	Mus musculus	41-44
23237229-13	2013	Lys(Dap)-precursors allow high-yield (99m)Tc-labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+), forming small and hydrophilic complexes, which in turn leads to peptide radiopharmaceuticals with excellent in vivo characteristics.	Lysine	0-3	death-associated protein	Mus musculus	4-7
23253442-1	2013	Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody.	Lysine	144-150	growth hormone 1	Homo sapiens	6-20
23088652-4	2013	Treatment of apoA-I with HOSCN resulted in the oxidation of tryptophan residues, whereas OCN- induced carbamylation of lysine residues to yield homocitrulline.	Lysine	119-125	bone gamma-carboxyglutamate protein	Homo sapiens	89-92
23172354-3	2013	At pH 6.5 a monocoordinated complex [Fe(II)(BP1)] was formed instead (K(f) = 2.1 x 10(5) M(-1)) due to electrostatic repulsion between the polyanionic dendrimer branches, as confirmed by the behavior of three analogues where glutamates were partially or completely replaced by neutral glutamines or positive lysines.	Lysine	308-315	BP1	Homo sapiens	44-47
23256662-0	2013	Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(epsilon)omega-carboxyheptadecanoyl) des(B30).	Lysine	107-110	insulin	Homo sapiens	90-97
23256662-1	2013	Lys(B29)(N(epsilon)omega-carboxyheptadecanoyl) des(B30) human insulin is an insulin analogue belonging to a class of analogues designed to form soluble depots in subcutis by self-association, aiming at a protracted action.	Lysine	0-3	insulin	Homo sapiens	62-69
23256662-1	2013	Lys(B29)(N(epsilon)omega-carboxyheptadecanoyl) des(B30) human insulin is an insulin analogue belonging to a class of analogues designed to form soluble depots in subcutis by self-association, aiming at a protracted action.	Lysine	0-3	insulin	Homo sapiens	76-83
23148227-8	2013	Furthermore, RUNX1 was associated with p300 histone acetyltransferase, and ADR-dependent acetylation of p53 at Lys-373/382 was markedly inhibited in RUNX1 knockdown cells.	Lysine	111-114	tumor protein p53	Homo sapiens	104-107
23234567-3	2013	According to infrared absorption, fibrils from bovine insulin ([BI]) and Lys(B31)-Arg(B32) human insulin analogue ([KR]) cross-seed each other and imprint distinct structural features in daughter fibrils.	Lysine	73-76	insulin	Homo sapiens	97-104
23291379-9	2013	In silico modeling suggested that ethanol alters the dynamics for assembling Abeta by disrupting a critical salt bridge between residues Asp 23 and Lys 28, required for amyloid dimerization.	Lysine	148-151	amyloid beta precursor protein	Homo sapiens	77-82
23300338-3	2013	The identification of an E3 ligase for Lys(63)-linked ubiquitination of Akt has now been complemented with the discovery of the tumor suppressor cylindromatosis as a deubiquitinating enzyme (DUB) for Akt.	Lysine	39-42	AKT serine/threonine kinase 1	Homo sapiens	72-75
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Lysine	138-141	tachykinin precursor 1	Homo sapiens	42-54
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Lysine	138-141	tachykinin precursor 1	Homo sapiens	56-74
23244738-2	2013	As it was observed for other tachykinins (neurokinin A, neuropeptide gamma and its fragments) containing the same C-terminal sequence His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH(2), also for the fragments of neuropeptide K the additional deprotonation most likely on the serine OH group was observed.	Lysine	138-141	tachykinin precursor 1	Homo sapiens	207-221
23889986-1	2013	Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers.	Lysine	148-154	metadherin	Homo sapiens	95-100
23889988-1	2013	Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002.	Lysine	71-77	metadherin	Homo sapiens	0-25
23889988-1	2013	Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002.	Lysine	71-77	metadherin	Homo sapiens	27-32
23889988-1	2013	Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002.	Lysine	71-77	metadherin	Homo sapiens	103-108
23359867-4	2013	Lysine 591 of menin was covalently modified by SUMO1 and K591R mutation in menin blocked SUMOylation of the C-terminal part of menin in transfected cells.	Lysine	0-6	menin 1	Homo sapiens	14-19
23359867-4	2013	Lysine 591 of menin was covalently modified by SUMO1 and K591R mutation in menin blocked SUMOylation of the C-terminal part of menin in transfected cells.	Lysine	0-6	menin 1	Homo sapiens	75-80
23359867-4	2013	Lysine 591 of menin was covalently modified by SUMO1 and K591R mutation in menin blocked SUMOylation of the C-terminal part of menin in transfected cells.	Lysine	0-6	menin 1	Homo sapiens	75-80
23168412-0	2013	Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIII.	Lysine	30-33	von Willebrand factor	Homo sapiens	59-80
23168412-4	2013	Nano-LC-MS analysis showed that the lysine residues of almost all identified VWF peptides were not differentially modified upon incubation of VWF with FVIII or activated FVIII.	Lysine	36-42	von Willebrand factor	Homo sapiens	77-80
23168412-6	2013	In addition, peptide Ser-764-Arg-782, which comprises the first 19 amino acid residues of mature VWF, showed a differential modification of both Lys-773 and the alpha-amino group of Ser-764.	Lysine	145-148	von Willebrand factor	Homo sapiens	97-100
23614352-1	2013	EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	116-122	enhancer of zeste 1 polycomb repressive complex 2 subunit	Mus musculus	8-12
23247593-12	2013	CONCLUSION: In U266 cells, berberine suppresses NF-kappaB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis.	Lysine	98-104	nuclear factor kappa B subunit 1	Homo sapiens	48-57
22861820-5	2013	Since carbamylation targets lysine residues on rHuEPo, we hypothesized that targeted lysine modifications of rHuEPO may result in a novel non-erythropoietic erythropoietin.	Lysine	28-34	erythropoietin	Homo sapiens	157-171
22861820-5	2013	Since carbamylation targets lysine residues on rHuEPo, we hypothesized that targeted lysine modifications of rHuEPO may result in a novel non-erythropoietic erythropoietin.	Lysine	85-91	erythropoietin	Homo sapiens	157-171
22861820-16	2013	CONCLUSIONS AND IMPLICATIONS: Herein, we describe a novel lysine-modified rHuEPO, glutaradehyde-EPO (GEPO), obtained from a simple reaction.	Lysine	58-64	erythropoietin	Homo sapiens	77-80
22890573-8	2013	Interestingly, snapin was ubiquitinated by RNF13 via the lysine-29 conjugated polyubiquitin chain, which in turn promoted the association of snapin with SNAP-25.	Lysine	57-63	ring finger protein 13	Mus musculus	43-48
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Lysine	57-60	interleukin 2	Homo sapiens	191-195
23255093-2	2013	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb-repressive complexes 2 (PRC2) that promotes trimethylation of lysine 27 of histone H3, leading to altered expression of tumor suppressors or oncogenes.	Lysine	134-140	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
23255093-2	2013	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb-repressive complexes 2 (PRC2) that promotes trimethylation of lysine 27 of histone H3, leading to altered expression of tumor suppressors or oncogenes.	Lysine	134-140	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
23448461-0	2013	Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.	Lysine	0-6	CREB binding protein	Homo sapiens	26-29
22868271-4	2013	recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.	Lysine	103-109	tet methylcytosine dioxygenase 3	Homo sapiens	160-164
23439558-5	2013	Moreover, although the Gfap promoter region containing the STAT3-binding site (GSBS) is enriched with transcription-repressive histone modifications, such as methylation of H3 at lysine 9 (H3K9me3) and H3K27me3, the reduction of these modifications in TKO ESCs was not sufficient for binding of STAT3 at GSBS.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	59-64
23033946-0	2013	Molecular properties of lysine dendrimers and their interactions with Abeta-peptides and neuronal cells.	Lysine	24-30	amyloid beta precursor protein	Homo sapiens	70-75
23448461-4	2013	This review focuses on two highly related epigenetic factors that are directly involved in a number of neurological disorders, the lysine acetyltransferases CREB-binding protein (CBP) and E1A-associated protein p300 (p300).	Lysine	131-137	CREB binding protein	Homo sapiens	157-177
23448461-4	2013	This review focuses on two highly related epigenetic factors that are directly involved in a number of neurological disorders, the lysine acetyltransferases CREB-binding protein (CBP) and E1A-associated protein p300 (p300).	Lysine	131-137	CREB binding protein	Homo sapiens	179-182
23097442-5	2013	Alanine scanning mutagenesis revealed that Lys(97) and Arg(98) in the alpha-helix of the JEV core protein play a crucial role in the interaction with Caprin-1.	Lysine	43-46	cell cycle associated protein 1	Homo sapiens	150-158
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 12	Homo sapiens	77-82
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 5	Homo sapiens	108-112
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 12	Homo sapiens	132-137
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 5	Homo sapiens	138-142
23151486-3	2013	Here we report a genome-wide association study (GWAS) designed to identify genetic loci controlling whole blood cytokine responses to the TLR1/2 lipopeptide agonist, Pam(3)CSK(4) (N-palmitoyl-S-dipalmitoylglyceryl Cys-Ser-(Lys)(4)) ex vivo.	Lysine	223-226	toll like receptor 1	Homo sapiens	138-144
23606839-0	2013	Glucagon-Like Peptide-1 Receptor Imaging with [Lys (40) (Ahx-HYNIC- (99 m) Tc/EDDA)NH 2 ]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer: A Preliminary Report.	Lysine	47-50	glucagon	Homo sapiens	0-23
24171769-3	2013	SIRT6- dependent deacetylation of histone H3 at lysines 9 and 56 is required for the regulation of genes associated with glucose/ lipid metabolism as well as the maintenance of telomeric regions and the repair of DNA double strand breaks.	Lysine	48-55	sirtuin 6	Mus musculus	0-5
24020203-3	2013	Here, we study the photodynamical properties of a Lys(+)-Trp pair in the protein human serum albumin (HSA) using nonadiabatic mixed time-dependent density functional theory/molecular mechanics simulations (TDDFT/MM).	Lysine	50-53	albumin	Homo sapiens	87-100
23306522-0	2013	Alteration of histone H3 lysine 4 trimethylation on putative lytic gene promoters by human Set1 complex during reactivation of Kaposi"s sarcoma-associated herpesvirus.	Lysine	25-31	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	91-95
23306522-1	2013	OBJECTIVE: Histone H3 lysine 4 is trimethylated by the human Set1 complex, which regulates the activation of gene expression.	Lysine	22-28	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	61-65
22971966-2	2013	In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues.	Lysine	139-142	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-84
23681529-7	2013	FAAH has been extensively characterized in mammalian and plant systems, and they share a conserved Ser-Ser-Lys catalytic mechanism.	Lysine	107-110	fatty acid amide hydrolase	Homo sapiens	0-4
23147254-3	2013	Here we discuss new evidence for a BAP1-independent function of ASXL1 in regulating histone H3 lysine 27 methylation through interactions with the Polycomb-repressive complex 2 (PRC2).	Lysine	95-101	BRCA1 associated protein 1	Homo sapiens	35-39
24193185-4	2013	By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first and then the unacetylated lysine group liberating puromycin.	Lysine	26-32	cathepsin L	Homo sapiens	153-164
24193185-4	2013	By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first and then the unacetylated lysine group liberating puromycin.	Lysine	26-32	cathepsin L	Homo sapiens	166-170
24193185-4	2013	By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first and then the unacetylated lysine group liberating puromycin.	Lysine	233-239	cathepsin L	Homo sapiens	153-164
24193185-4	2013	By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first and then the unacetylated lysine group liberating puromycin.	Lysine	233-239	cathepsin L	Homo sapiens	166-170
23382701-5	2013	Here, we unveil the role of Dot1-dependent histone H3 methylation at lysine 79 (H3K79me) in this meiotic surveillance mechanism.	Lysine	69-75	DOT1 like histone lysine methyltransferase	Homo sapiens	28-32
23314848-6	2013	PKL/EPP1 in turn negatively regulates HY5 by repressing trimethylation of histone H3 Lys 27 at the target loci, thereby regulating the expression of these genes and, thus, hypocotyl elongation.	Lysine	85-88	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	38-41
23516383-3	2013	Depleting maternal HDAC2 results in hyperacetylation of H4K16 as determined by immunocytochemistry--normal deacetylation of other lysine residues of histone H3 or H4 is observed--and defective chromosome condensation and segregation during oocyte maturation occurs in a sub-population of oocytes.	Lysine	130-136	histone deacetylase 2	Mus musculus	19-24
23451270-0	2013	The angiotensin II type 1 receptor C-terminal Lys residues interact with tubulin and modulate receptor export trafficking.	Lysine	46-49	angiotensinogen	Homo sapiens	4-18
23555753-7	2013	Moreover, TSA increased the level of NF-kappaB p65 acetylation at lysine 310 and duration of its translocation into the nucleus, which leads to enhancement of NF-kappaB activity and subsequently expression of inflammatory genes.	Lysine	66-72	nuclear factor kappa B subunit 1	Homo sapiens	37-46
23555753-7	2013	Moreover, TSA increased the level of NF-kappaB p65 acetylation at lysine 310 and duration of its translocation into the nucleus, which leads to enhancement of NF-kappaB activity and subsequently expression of inflammatory genes.	Lysine	66-72	nuclear factor kappa B subunit 1	Homo sapiens	159-168
23536830-5	2013	NF-kappaB p65 Lys(310) acetylation and Ser(276) phosphorylation were detected in co-transfection experiments with NF-kappaB p65 and ORFV002 or its mutants with, or without, the N-terminal region.	Lysine	14-17	nuclear factor kappa B subunit 1	Homo sapiens	0-9
23935533-2	2013	There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys in humans), strongly suggesting a loss of proteolytic activity.	Lysine	183-186	calpain 6	Homo sapiens	80-89
23935533-2	2013	There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys in humans), strongly suggesting a loss of proteolytic activity.	Lysine	183-186	calpain 6	Homo sapiens	91-96
23533620-8	2013	In addition, the M-4 tail was itself mono-ubiquitinated on a lysine residue in both 293T cells and a human T cell line.	Lysine	61-67	cholinergic receptor, muscarinic 4	Mus musculus	17-20
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	small ubiquitin-like modifier 2	Mus musculus	21-54
23105103-9	2012	Promoter swapping and site-directed mutagenesis of GDH1 and GDH3 indicated that the necessity of GDH3 for the resistance to stress-induced apoptosis and chronological aging is due to the stationary phase-specific expression of GDH3 and concurrent degradation of Gdh1 in which the Lys-426 residue plays an essential role.	Lysine	280-283	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	60-64
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	small ubiquitin-like modifier 2	Mus musculus	56-64
23907581-0	2013	Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.	Lysine	43-49	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	35-39
23907581-0	2013	Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.	Lysine	43-49	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
23907581-4	2013	Here we report that BRAF is modified by Lys63-linked polyubiquitination at lysine 578 within its kinase domain once it is activated by gain of constitutively active mutation or epidermal growth factor (EGF) stimulation.	Lysine	75-81	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	20-24
23152497-9	2012	Chromatin immunoprecipitation (ChIP) assays revealed that KDM6B promoted SNAI1 expression by removing histone H3 lysine trimethylation marks.	Lysine	113-119	snail family transcriptional repressor 1	Homo sapiens	73-78
23105103-9	2012	Promoter swapping and site-directed mutagenesis of GDH1 and GDH3 indicated that the necessity of GDH3 for the resistance to stress-induced apoptosis and chronological aging is due to the stationary phase-specific expression of GDH3 and concurrent degradation of Gdh1 in which the Lys-426 residue plays an essential role.	Lysine	280-283	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	97-101
23105103-9	2012	Promoter swapping and site-directed mutagenesis of GDH1 and GDH3 indicated that the necessity of GDH3 for the resistance to stress-induced apoptosis and chronological aging is due to the stationary phase-specific expression of GDH3 and concurrent degradation of Gdh1 in which the Lys-426 residue plays an essential role.	Lysine	280-283	glutamate dehydrogenase (NADP(+)) GDH3	Saccharomyces cerevisiae S288C	97-101
23236167-1	2012	Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development.	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
23271465-7	2012	By phosphoproteomics analysis, six proteins, including MAPK1, were identified up-expressed in DCMECs treated with 1.2 mM L-Lys for 24 h, and were verified by quantitative real-time PCR (qRT-PCR) and western blot.	Lysine	121-126	mitogen-activated protein kinase 1	Bos taurus	55-60
23236167-1	2012	Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development.	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-33
23256224-13	2004	[(111)In]3 is a bivalent compound that was synthesized by incorporating a PSMA-binding Lys-Glu urea motif for exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety (8).	Lysine	87-90	folate hydrolase 1	Homo sapiens	74-78
23256225-13	2004	[(111)In]3 is a bivalent compound that was synthesized by incorporating a PSMA-binding Lys-Glu urea motif for exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety (1).	Lysine	87-90	folate hydrolase 1	Homo sapiens	74-78
23109336-0	2012	BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.	Lysine	92-98	beta-secretase 1	Homo sapiens	0-5
23103096-2	2012	In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed.	Lysine	107-113	homeobox C10	Homo sapiens	42-46
23086925-4	2012	A large number of JQ1-disrupted BRD4 binding regions exhibited diacetylated H4 (lysine 5 and -8) and H3K27 acetylation (H3K27ac), which correlated with the presence of histone acetyltransferases and deacetylases.	Lysine	80-86	bromodomain containing 4	Homo sapiens	32-36
23249736-7	2012	These RNF8-dependent modifications include trimethylation of H3K4, histone lysine crotonylation (Kcr), and incorporation of the histone variant H2AFZ.	Lysine	75-81	ring finger protein 8	Mus musculus	6-10
23100253-5	2012	The tudor domain (residues 1-62) of LBR primarily recognizes histone H4 lysine 20 dimethylation and is essential for chromatin compaction, whereas the whole nucleoplasmic region (residues 1-211) is required for transcriptional repression.	Lysine	72-78	lamin B receptor	Homo sapiens	36-39
23109336-5	2012	Here, we report that lack of ubiquitination at Lys-501 (BACE1K501R) does not affect the rate of endocytosis but produces BACE1 stabilization and accumulation of BACE1 in early and late endosomes/lysosomes as well as at the cell membrane.	Lysine	47-50	beta-secretase 1	Homo sapiens	56-61
23109336-5	2012	Here, we report that lack of ubiquitination at Lys-501 (BACE1K501R) does not affect the rate of endocytosis but produces BACE1 stabilization and accumulation of BACE1 in early and late endosomes/lysosomes as well as at the cell membrane.	Lysine	47-50	beta-secretase 1	Homo sapiens	121-126
23109336-4	2012	The BACE1 carboxyl-terminal fragment contains a di-leucine sorting signal ((495)DDISLL(500)) and a ubiquitination site at Lys-501.	Lysine	122-125	beta-secretase 1	Homo sapiens	4-9
23109336-8	2012	Finally, BACE1LLAA/KR accumulates in the TGN, while its levels are decreased in EEA1-positive compartments indicating that both ubiquitination at Lys-501 and the di-leucine motif are necessary for the trafficking of BACE1 from the TGN to early endosomes.	Lysine	146-149	beta-secretase 1	Homo sapiens	9-14
23109336-9	2012	Our studies have elucidated a differential role for the di-leucine motif and ubiquitination at Lys-501 in BACE1 endocytosis, trafficking, and degradation and suggest the involvement of multiple adaptor molecules.	Lysine	95-98	beta-secretase 1	Homo sapiens	106-111
23076146-6	2012	Mechanistically, SIRT6 interacts with c-JUN and deacetylates histone H3 lysine 9 (H3K9) at the promoter of proinflammatory genes whose expression involves the c-JUN signaling pathway.	Lysine	72-78	sirtuin 6	Mus musculus	17-22
23201684-7	2012	Using gain- and loss-of-function mutants, we demonstrate that acetylation of RIP1 lysine 530 modulates RIP1-RIP3 complex formation and TNF-alpha-stimulated necrosis.	Lysine	82-88	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	77-81
23201684-7	2012	Using gain- and loss-of-function mutants, we demonstrate that acetylation of RIP1 lysine 530 modulates RIP1-RIP3 complex formation and TNF-alpha-stimulated necrosis.	Lysine	82-88	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	103-107
23201684-7	2012	Using gain- and loss-of-function mutants, we demonstrate that acetylation of RIP1 lysine 530 modulates RIP1-RIP3 complex formation and TNF-alpha-stimulated necrosis.	Lysine	82-88	tumor necrosis factor	Mus musculus	135-144
23169648-5	2012	TRIM28 binds to Ealpha and induces histone 3 lysine 4 trimethylation in the Ealpha and distant regions of the TCRalpha locus, coupled with recruitment of Rag proteins.	Lysine	45-51	tripartite motif containing 28	Homo sapiens	0-6
23095741-4	2012	Numerous studies support the hypothesis that during tRNA(Lys) packaging, a Gag GagPol complex interacts with a tRNA(Lys) LysRS complex, with Gag interacting specifically with the catalytic domain of LysRS, and GagPol interacting with both Gag and tRNA(Lys).	Lysine	57-60	lysyl-tRNA synthetase 1	Homo sapiens	121-126
23137334-0	2012	Positron emission tomography imaging of vascular endothelial growth factor receptor expression with (61)Cu-labeled lysine-tagged VEGF121.	Lysine	115-121	vascular endothelial growth factor A	Homo sapiens	40-74
23275887-8	2012	Furthermore, analyses of methylation status of histone H3 lysine 27 (H3K27me) from the published modENCODE data sets suggest that the genomic regions harboring dE2f1 gene and certain dE2f1 target genes display H3K27me during development and in several Drosophila cell lines.	Lysine	58-64	E2F transcription factor 1	Drosophila melanogaster	160-165
23275887-8	2012	Furthermore, analyses of methylation status of histone H3 lysine 27 (H3K27me) from the published modENCODE data sets suggest that the genomic regions harboring dE2f1 gene and certain dE2f1 target genes display H3K27me during development and in several Drosophila cell lines.	Lysine	58-64	E2F transcription factor 1	Drosophila melanogaster	183-188
22711031-4	2012	EZH2 is the catalytic subunit of Polycomb repressive complex 2 (PRC2), which methylates histone H3 lysine 27, thereby silencing several tumor-suppressor genes.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
22978415-1	2012	DOT1L is the human protein methyltransferase responsible for catalyzing the methylation of histone H3 on lysine 79 (H3K79).	Lysine	105-111	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
22524975-0	2012	The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men.	Lysine	55-61	insulin	Homo sapiens	98-105
32480855-1	2012	In Arabidopsis thalinana (L.) Heynh., DHDPS1 and DHDPS2 encode orthologous dihydrodipicolinate synthases (DHDPS), the first enzyme of the lysine (Lys) biosynthesis pathway.	Lysine	138-144	dihydrodipicolinate synthase 1	Arabidopsis thaliana	38-44
32480855-1	2012	In Arabidopsis thalinana (L.) Heynh., DHDPS1 and DHDPS2 encode orthologous dihydrodipicolinate synthases (DHDPS), the first enzyme of the lysine (Lys) biosynthesis pathway.	Lysine	146-149	dihydrodipicolinate synthase 1	Arabidopsis thaliana	38-44
32480855-6	2012	dhdps1-dhdps2 double mutants could not be isolated, even after exogenous feeding with Lys.	Lysine	86-89	dihydrodipicolinate synthase 1	Arabidopsis thaliana	0-6
23127165-2	2012	Here we study the formation of amyloid fibrils from bovine insulin and the recombinant Lys(B31)-Arg(B32) human insulin analog.	Lysine	87-90	insulin	Homo sapiens	111-118
22995936-6	2012	This effect may be linked to methyltransferase activity of SETDB1, such as trimethylation of lysine 9 of histone 3 (H3K9me3), deposition of which was decreased at the human TNF locus upon KAP1 knockdown.	Lysine	93-99	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	59-65
22995936-6	2012	This effect may be linked to methyltransferase activity of SETDB1, such as trimethylation of lysine 9 of histone 3 (H3K9me3), deposition of which was decreased at the human TNF locus upon KAP1 knockdown.	Lysine	93-99	tumor necrosis factor	Homo sapiens	173-176
22995936-6	2012	This effect may be linked to methyltransferase activity of SETDB1, such as trimethylation of lysine 9 of histone 3 (H3K9me3), deposition of which was decreased at the human TNF locus upon KAP1 knockdown.	Lysine	93-99	tripartite motif containing 28	Homo sapiens	188-192
22904200-3	2012	EZH2 is the catalytic component of the polycomb group repressive complex (PRC2), which selectively methylates histone H3 lysine 27 (H3K27).	Lysine	121-127	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
23071112-8	2012	Lysine at position 296 of Galpha(i2) was identified as the critical determinant of Nef-induced degradation.	Lysine	0-6	S100 calcium binding protein B	Homo sapiens	83-86
23233849-5	2012	By analyzing a further series of mutants, we found that Phe-to-Lys substitution (F318K) caused the most significant reduction in the EC(50) value of MCH for calcium mobilization without affecting receptor expression at the cell surface.	Lysine	63-66	oleoyl-ACP hydrolase	Rattus norvegicus	149-152
23127165-5	2012	Although the differences in primary structure between bovine insulin and the Lys(B31)-Arg(B32) analog of human insulin lie outside of the polypeptide"s critical amyloidogenic regions, they affect the secondary structure of fibrils, possibly the formation of intermolecular salt bridges, and the susceptibility to dissection and denaturation with dimethyl sulfoxide (DMSO).	Lysine	77-80	insulin	Homo sapiens	111-118
23060441-6	2012	The alpha1(V) collagenous COL1 domain is thought to contain greater numbers of post-translational modifications (PTMs) than do similar domains of other fibrillar collagen chains, PTMs consisting of hydroxylated prolines and lysines, the latter of which can be glycosylated.	Lysine	224-231	collagen type V alpha 1 chain	Homo sapiens	4-13
22955928-6	2012	These results are particularly important in view of HDAC6 inhibitors being currently used in clinical trials and represent the first example of cell signaling by lysine acetylation in platelet biology.	Lysine	162-168	histone deacetylase 6	Homo sapiens	52-57
23110300-3	2012	Moreover, the BaxC-KK peptide, as well as two mutants where the two lysines are replaced with glutamate (BaxC-EE) or leucine (BaxC-LL), have been shown to form relatively large pores in lipid membranes, composed of up to eight peptide molecules per pore.	Lysine	68-75	BCL2 associated X, apoptosis regulator	Homo sapiens	14-21
22906073-5	2012	This lysine residue is conserved in the active sites of the four human PYK isoenzymes, which were also found to be irreversibly inhibited by DBS.	Lysine	5-11	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	71-74
23091032-4	2012	In this study, we showed that this was due to the negative regulation of Jhd2 activity by histone H3 lysine 14 acetylation (H3K14ac), which colocalizes with H3K4me3 across the yeast genome.	Lysine	101-107	histone demethylase	Saccharomyces cerevisiae S288C	73-77
23285694-0	2012	Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts.	Lysine	31-34	tumor necrosis factor	Homo sapiens	65-74
23285694-0	2012	Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts.	Lysine	31-34	interleukin 6	Homo sapiens	85-89
22583696-9	2012	Since H4 and p53 both contain the target lysine in an unstructured part of the protein, we conclude that the long recognition sequence of SET8 makes it difficult to methylate a lysine in a folded region of a protein, because amino acid side chains essential for recognition will be buried.	Lysine	41-47	tumor protein p53	Homo sapiens	13-16
22403019-4	2012	Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10 mM) increased apoptosis (+30%; p &lt; 0.01 vs.C), as well as Bax and Apaf-1 expressions (+30-50% p &lt; 0.05), while downregulated Bcl-2 (-40% p &lt; 0.05).	Lysine	22-28	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
22966008-1	2012	The histone methyltransferase enhancer of zeste homolog 2 (Ezh2) mediates trimethylation of lysine 27 in histone 3, which acts as a repressive epigenetic mark.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-57
22966008-1	2012	The histone methyltransferase enhancer of zeste homolog 2 (Ezh2) mediates trimethylation of lysine 27 in histone 3, which acts as a repressive epigenetic mark.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
22966008-6	2012	To identify direct target genes of Ezh2, we performed chromatin immunoprecipitation experiments followed by whole-genome promoter arrays (chromatin immunoprecipitation-on-chip) and identified 5585 genes associated with trimethylation of lysine 27 in histone 3.	Lysine	237-243	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	35-39
22966008-7	2012	Comparative analysis with our mRNA expression data identified 276 genes that met our criteria for putative Ezh2 target genes, upregulation by &gt;2-fold after Ezh2 silencing and association with trimethylation of lysine 27 in histone 3.	Lysine	213-219	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	107-111
22966008-9	2012	Epigenetic regulation of several of these genes by Ezh2 was specifically confirmed by polymerase chain reaction analysis of DNA enrichment after chromatin immunoprecipitation using an antibody specific for trimethylation of lysine 27 in histone 3.	Lysine	224-230	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	51-55
22403019-4	2012	Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10 mM) increased apoptosis (+30%; p &lt; 0.01 vs.C), as well as Bax and Apaf-1 expressions (+30-50% p &lt; 0.05), while downregulated Bcl-2 (-40% p &lt; 0.05).	Lysine	22-28	apoptotic peptidase activating factor 1	Homo sapiens	173-179
22403019-4	2012	Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10 mM) increased apoptosis (+30%; p &lt; 0.01 vs.C), as well as Bax and Apaf-1 expressions (+30-50% p &lt; 0.05), while downregulated Bcl-2 (-40% p &lt; 0.05).	Lysine	22-28	BCL2 apoptosis regulator	Homo sapiens	235-240
22403019-5	2012	Apoptosis induced by high Lysine was no longer observed after addition of caspase-9 and caspase-3 inhibitors while caspase-8 inhibitor had no protective effect.	Lysine	26-32	caspase 3	Homo sapiens	88-97
22403019-6	2012	High Lysine induced elevations in ROS generation and NADPH oxidase subunits mRNAs (p22 (phox) +106 +- 23%, p67 (phox) +108 +- 22% and gp91 (phox) +75 +- 4% p &lt; 0.05-0.01).	Lysine	5-11	CD33 molecule	Homo sapiens	107-110
22924711-7	2012	LPS increased p38 MAPK and JNK phosphorylation at 4 and 2-4 h, respectively, whereas treatment reduced p38 MAPK and JNK phosphorylation only at 2 h. In addition, treatment reversed the LPS-induced elevation of NF-kappaB p65 protein and phosphorylation at serine 468 and induced acetylation at lysine 310.	Lysine	293-299	mitogen-activated protein kinase 14	Homo sapiens	103-106
22924711-7	2012	LPS increased p38 MAPK and JNK phosphorylation at 4 and 2-4 h, respectively, whereas treatment reduced p38 MAPK and JNK phosphorylation only at 2 h. In addition, treatment reversed the LPS-induced elevation of NF-kappaB p65 protein and phosphorylation at serine 468 and induced acetylation at lysine 310.	Lysine	293-299	mitogen-activated protein kinase 8	Homo sapiens	116-119
22676916-5	2012	Mutagenesis studies on the fragments of Usp indicated that sumoylation can occur alternatively on several defined Lys residues, i.e. three (Lys16, Lys20, Lys37) in A/B region, one (Lys424) in E region and one (Lys506) in F region.	Lysine	114-117	ultraspiracle	Drosophila melanogaster	40-43
22305405-1	2012	There is evidence that the E3 ubiquitin ligases muscle ring finger-1 (MuRF1) and atrogin-1, which mediate the ubiquitination of certain proteins and thereby their proteolysis, are regulated by cyclical nutritional treatments varying in lysine content.	Lysine	236-242	tripartite motif containing 63	Homo sapiens	70-75
22676916-7	2012	This was also observed for Lys residues in carboxyl-terminal fragment of Usp, i.e. comprising E and F regions.	Lysine	27-30	ultraspiracle	Drosophila melanogaster	73-76
23023262-1	2012	EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27).	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
22951831-9	2012	Finally, we identified that IRF7 is sumoylated at lysine 452.	Lysine	50-56	interferon regulatory factor 7	Homo sapiens	28-32
23013607-14	2012	The poly-l-lysine-coated surfaces nonspecifically adsorbed both concanavalin A and bovine serum albumin, while the poly(p-acrylamidophenyl-alpha-mannoside)-immobilized surface preferentially adsorbed concanavalin A.	Lysine	4-17	albumin	Homo sapiens	90-103
23110793-5	2012	Also, literature data are equivocal on the correlation between EZH2 expression and the abundance of trimethylated histone 3 lysine 27 (H3K27me3) motifs in tumors.	Lysine	124-130	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	63-67
23101626-4	2012	By limiting PRC2 loading and histone 3 lysine-27 trimethylation, Utf1 sets proper activation thresholds for bivalent genes.	Lysine	39-45	undifferentiated embryonic cell transcription factor 1	Homo sapiens	65-69
23197690-8	2012	Moreover, when plated on poly-l-lysine/laminin-coated slides in the presence of FGF-2, human chromaffin progenitor cells were able to differentiate into two distinct neuron-like cell types, tyrosine hydroxylase (TH)(+)/beta-3-tubulin(+) cells and TH(-)/beta-3-tubulin(+) cells, and into chromaffin cells (TH(+)/PNMT(+)).	Lysine	25-38	fibroblast growth factor 2	Homo sapiens	80-85
23197690-8	2012	Moreover, when plated on poly-l-lysine/laminin-coated slides in the presence of FGF-2, human chromaffin progenitor cells were able to differentiate into two distinct neuron-like cell types, tyrosine hydroxylase (TH)(+)/beta-3-tubulin(+) cells and TH(-)/beta-3-tubulin(+) cells, and into chromaffin cells (TH(+)/PNMT(+)).	Lysine	25-38	tyrosine hydroxylase	Homo sapiens	190-210
23041319-5	2012	S. cerevisiae Hsp90 is acetylated on lysine 27 and 270, and key KDACs for drug resistance are Hda1 and Rpd3.	Lysine	37-43	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	103-107
22942287-6	2012	Endopeptidase cleavage at Lys(91) generates a cleaved globular gCTRP12 isoform, the expression of which is increased by insulin.	Lysine	26-29	insulin	Homo sapiens	120-127
22930759-5	2012	TRalpha was sumoylated at lysines 283 and 389, and TRbeta at lysines 50, 146, and 443.	Lysine	61-68	T cell receptor beta locus	Homo sapiens	51-57
23045678-4	2012	ChIP assays showed increased levels of histone 3 lysine 9 acetylation and histone 3 lysine 4 trimethylation of Grm1 in hippocampus from the adult offspring of high-LG compared with low-LG mothers.	Lysine	84-90	glutamate metabotropic receptor 1	Rattus norvegicus	111-115
23083715-1	2012	High unitary Cl(-) conductance in the cystic fibrosis transmembrane conductance regulator Cl(-) channel requires a functionally unique, positively charged lysine residue (K95) in the inner vestibule of the channel pore.	Lysine	155-161	CF transmembrane conductance regulator	Homo sapiens	38-89
22683437-2	2012	Other individual reports identified lysine acetylation as a PTM regulating transcription factors and co-activators including p53, c-Myc, PGC1alpha and Ku70.	Lysine	36-42	tumor protein p53	Homo sapiens	125-128
22287205-1	2012	Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription.	Lysine	146-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-29
22287205-1	2012	Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription.	Lysine	146-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
22683437-2	2012	Other individual reports identified lysine acetylation as a PTM regulating transcription factors and co-activators including p53, c-Myc, PGC1alpha and Ku70.	Lysine	36-42	PPARG coactivator 1 alpha	Homo sapiens	137-146
22908229-0	2012	HIF1alpha protein stability is increased by acetylation at lysine 709.	Lysine	59-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
22771573-8	2012	However, above 400 muM [NTP], the concentration of lysine required to elicit transcription termination rises, moving into the riboswitch into a kinetic control regime.	Lysine	51-57	latexin	Homo sapiens	19-22
22908229-6	2012	Mechanistically, p300 specifically acetylates HIF1alpha at Lys-709, which increases the protein stability and decreases polyubiquitination in both normoxia and hypoxia.	Lysine	59-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-55
22908229-10	2012	Taken together, these data demonstrate a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation.	Lysine	152-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-84
22908229-10	2012	Taken together, these data demonstrate a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation.	Lysine	152-155	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-121
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Lysine	141-144	transportin 3	Homo sapiens	124-131
22420465-8	2012	All four deiminated arginines and one acetylated lysine were first experimentally revealed in this study for bovine MBP.	Lysine	49-55	myelin basic protein	Bos taurus	116-119
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Lysine	157-160	transportin 3	Homo sapiens	124-131
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Lysine	157-160	transportin 3	Homo sapiens	124-131
23062350-5	2012	In the complex with the most conformational entropy retention (CaM in complex with the neuronal nitric oxide synthase binding sequence), Lys-148 at the C-terminus of CaM forms transient salt bridges alternating between Glu side chains in the N-domain, the central linker, and the binding target.	Lysine	137-140	calmodulin 1	Homo sapiens	63-66
22902619-7	2012	Loss of Lys-30 ubiquitination of SLP-76 results in enhanced anti-CD3 antibody-induced ERK and JNK activation.	Lysine	8-11	mitogen-activated protein kinase 1	Homo sapiens	86-89
22902619-7	2012	Loss of Lys-30 ubiquitination of SLP-76 results in enhanced anti-CD3 antibody-induced ERK and JNK activation.	Lysine	8-11	mitogen-activated protein kinase 8	Homo sapiens	94-97
24900424-0	2012	SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington"s Disease.	Lysine	19-25	transglutaminase 2	Homo sapiens	59-77
23062350-5	2012	In the complex with the most conformational entropy retention (CaM in complex with the neuronal nitric oxide synthase binding sequence), Lys-148 at the C-terminus of CaM forms transient salt bridges alternating between Glu side chains in the N-domain, the central linker, and the binding target.	Lysine	137-140	calmodulin 1	Homo sapiens	166-169
22821000-7	2012	Finally, MPTP-treated wild-type and Ranbp2                         (+/-) mice present distinct metabolic footprints in the brain or selective regions thereof, such as striatum, that are supportive of RanBP2-mediated regulation of interdependent metabolic pathways of lysine, cholesterol, free-fatty acids, or their beta-oxidation.	Lysine	267-273	RAN binding protein 2	Mus musculus	36-42
22821000-7	2012	Finally, MPTP-treated wild-type and Ranbp2                         (+/-) mice present distinct metabolic footprints in the brain or selective regions thereof, such as striatum, that are supportive of RanBP2-mediated regulation of interdependent metabolic pathways of lysine, cholesterol, free-fatty acids, or their beta-oxidation.	Lysine	267-273	RAN binding protein 2	Mus musculus	200-206
22836039-7	2012	Addition of lysine to the enzymatic modification of gluten normalized interferon gamma, antibodies, transglutaminase activity and immunohistochemical expression of transglutaminase type 2.	Lysine	12-18	interferon gamma	Homo sapiens	70-86
22488010-7	2012	Accordingly, neonatal activation of CAR led to a permanent increase of histone 3 lysine 4 mono-, di-, and trimethylation and decrease of H3K9 trimethylation within the Cyp2B10 locus.	Lysine	81-87	nuclear receptor subfamily 1, group I, member 3	Mus musculus	36-39
22891617-4	2012	In this study, we demonstrated for the first time that acetylation levels of histone H3 lysine 9 (H3K9) at the promoter regions of clock genes, such as Dbp, Per2, and Bmal1, in the adipose tissue of ob/ob mice were significantly reduced compared with those of its control C57BL/6J mice.	Lysine	88-94	D site albumin promoter binding protein	Mus musculus	152-155
22891617-4	2012	In this study, we demonstrated for the first time that acetylation levels of histone H3 lysine 9 (H3K9) at the promoter regions of clock genes, such as Dbp, Per2, and Bmal1, in the adipose tissue of ob/ob mice were significantly reduced compared with those of its control C57BL/6J mice.	Lysine	88-94	period circadian clock 2	Mus musculus	157-161
22493095-3	2012	Sumoylation of HDAC2 at lysine 462 allows binding of HDAC2 to p53.	Lysine	24-30	histone deacetylase 2	Homo sapiens	15-20
22493095-3	2012	Sumoylation of HDAC2 at lysine 462 allows binding of HDAC2 to p53.	Lysine	24-30	histone deacetylase 2	Homo sapiens	53-58
22493095-3	2012	Sumoylation of HDAC2 at lysine 462 allows binding of HDAC2 to p53.	Lysine	24-30	tumor protein p53	Homo sapiens	62-65
22493095-5	2012	Deacetylation of p53 at lysine 320 by sumoylated HDAC2 blocks recruitment of p53 into promoter-associated complexes and p53-dependent expression of genes for cell cycle control and apoptosis.	Lysine	24-30	tumor protein p53	Homo sapiens	17-20
22493095-5	2012	Deacetylation of p53 at lysine 320 by sumoylated HDAC2 blocks recruitment of p53 into promoter-associated complexes and p53-dependent expression of genes for cell cycle control and apoptosis.	Lysine	24-30	histone deacetylase 2	Homo sapiens	49-54
22493095-5	2012	Deacetylation of p53 at lysine 320 by sumoylated HDAC2 blocks recruitment of p53 into promoter-associated complexes and p53-dependent expression of genes for cell cycle control and apoptosis.	Lysine	24-30	tumor protein p53	Homo sapiens	77-80
22493095-5	2012	Deacetylation of p53 at lysine 320 by sumoylated HDAC2 blocks recruitment of p53 into promoter-associated complexes and p53-dependent expression of genes for cell cycle control and apoptosis.	Lysine	24-30	tumor protein p53	Homo sapiens	77-80
22766277-1	2012	Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3).	Lysine	154-160	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	57-84
22766277-1	2012	Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3).	Lysine	154-160	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	86-90
22865765-1	2012	The versatility of the pipecolic linker (Pip-linker) is illustrated by the synthesis of modified amino acids, C-terminal-modified pseudopeptides, and cyclic peptides, through side-chain anchoring of a lysine residue (see figure).	Lysine	201-207	prolactin induced protein	Homo sapiens	41-44
22961379-4	2012	Proper AGO1 and AGO2 recruitment to CD44 transcribed regions required the endonuclease Dicer and the chromobox protein HP1gamma, and resulted in increased histone H3 lysine 9 methylation on variant exons.	Lysine	166-172	argonaute RISC component 1	Homo sapiens	7-11
22961379-4	2012	Proper AGO1 and AGO2 recruitment to CD44 transcribed regions required the endonuclease Dicer and the chromobox protein HP1gamma, and resulted in increased histone H3 lysine 9 methylation on variant exons.	Lysine	166-172	argonaute RISC catalytic component 2	Homo sapiens	16-20
22696202-0	2012	Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage.	Lysine	25-31	tumor protein p53	Homo sapiens	43-46
22801425-6	2012	Further, Ca(2+)/CaM interacts with the highly conserved residues (Glu(319)-Lys(341)) toward the C-terminal end of the motif.	Lysine	75-78	calmodulin 1	Homo sapiens	16-19
22696202-0	2012	Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage.	Lysine	25-31	tumor protein p53	Homo sapiens	108-111
22696202-6	2012	In this study we have investigated whether the expression of BCR-ABL could influence the acetylation of p53, specifically at lysine 317/320 (K317/K320), which has been shown to regulate nuclear export and transcription-independent apoptotic activity of p53.	Lysine	125-131	tumor protein p53	Homo sapiens	104-107
22745382-6	2012	JMJD2B played an important role in CRC cell proliferation, apoptosis, cell cycle arrest and invasion, which could be modulated through upregulation of a subset of hypoxia-inducible genes expression by decreasing trimethylation of histone H3 lysine 9 on their promoters.	Lysine	241-247	lysine demethylase 4B	Homo sapiens	0-6
22361683-3	2012	A lysine-less NOXA (NOXA-LL) mutant, which is not ubiquitinated, is degraded at a similar rate to wild-type NOXA.	Lysine	2-8	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	14-18
22361683-3	2012	A lysine-less NOXA (NOXA-LL) mutant, which is not ubiquitinated, is degraded at a similar rate to wild-type NOXA.	Lysine	2-8	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	20-27
22361683-3	2012	A lysine-less NOXA (NOXA-LL) mutant, which is not ubiquitinated, is degraded at a similar rate to wild-type NOXA.	Lysine	2-8	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	20-24
22593014-6	2012	Moreover, site-directed mutagenesis demonstrated the involvement of lysines 517 and 526 of GLT-1 in the constitutive internalization of the transporter.	Lysine	68-75	solute carrier family 1 member 2	Homo sapiens	91-96
22691877-6	2012	The channel function of claudin-4 is conferred by a charged lysine residue (K65) in its extracellular loop.	Lysine	60-66	claudin 4	Homo sapiens	24-33
22684523-5	2012	We have found that anergy-induced deacetylation of the Il2 promoter permits binding of the histone methyl-transferase Suv39H1, which trimethylates lysine-9 of histone H3 (Me3H3-K9).	Lysine	147-153	interleukin 2	Homo sapiens	55-58
22684523-5	2012	We have found that anergy-induced deacetylation of the Il2 promoter permits binding of the histone methyl-transferase Suv39H1, which trimethylates lysine-9 of histone H3 (Me3H3-K9).	Lysine	147-153	SUV39H1 histone lysine methyltransferase	Homo sapiens	118-125
22778132-7	2012	Finally, we show that Ess1 is required for trimethylation of histone H3 lysine 4 (H3K4).	Lysine	72-78	peptidylprolyl isomerase ESS1	Saccharomyces cerevisiae S288C	22-26
22699452-1	2012	Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a potential therapeutic target in solid cancers and more recently in acute myeloid leukemia.	Lysine	0-6	lysine (K)-specific demethylase 1A	Mus musculus	36-40
22699452-1	2012	Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a potential therapeutic target in solid cancers and more recently in acute myeloid leukemia.	Lysine	0-6	lysine (K)-specific demethylase 1A	Mus musculus	41-46
22575419-0	2012	Investigation of the mechanism(s) involved in decreasing increased fibrinogen activity in hyperglycemic conditions using L-lysine supplementation.	Lysine	121-129	fibrinogen beta chain	Homo sapiens	67-77
22864287-0	2012	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.	Lysine	43-49	tumor protein p53	Homo sapiens	32-35
22864287-0	2012	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.	Lysine	43-49	tumor protein p53	Homo sapiens	92-95
22575419-3	2012	In this study, the inhibitory effect of L-Lysine (Lys) on the nonenzymatic glycation of fibrinogen was investigated in both in vitro and in vivo conditions.	Lysine	40-48	fibrinogen beta chain	Homo sapiens	88-98
22575419-3	2012	In this study, the inhibitory effect of L-Lysine (Lys) on the nonenzymatic glycation of fibrinogen was investigated in both in vitro and in vivo conditions.	Lysine	42-45	fibrinogen beta chain	Homo sapiens	88-98
22575419-4	2012	MATERIALS AND METHODS: Fibrinogen was incubated with glucose in the presence or absence of Lys.	Lysine	91-94	fibrinogen beta chain	Homo sapiens	23-33
22863776-2	2012	Rpd3S recognizes methylation of histone H3 at lysine 36 (H3K36me), which is required for its deacetylation activity.	Lysine	46-52	histone deacetylase 1	Homo sapiens	0-4
22939621-3	2012	Analysis of histone methyltransferases (HMTs) showed that elimination of two HMTs, MET-2 and SET-25, mimics the loss of SAM synthetase, abrogating the perinuclear attachment of heterochromatic transgenes and of native chromosomal arms rich in histone H3 lysine 9 methylation.	Lysine	254-260	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	83-88
22939621-3	2012	Analysis of histone methyltransferases (HMTs) showed that elimination of two HMTs, MET-2 and SET-25, mimics the loss of SAM synthetase, abrogating the perinuclear attachment of heterochromatic transgenes and of native chromosomal arms rich in histone H3 lysine 9 methylation.	Lysine	254-260	Histone-lysine N-methyltransferase set-25	Caenorhabditis elegans	93-99
22847419-4	2012	The Rossmann fold containing NAD(+) binding region on GAPDH is responsible for the interaction with TERC, whereas a lysine residue in the GAPDH catalytic domain is required for inhibiting telomerase activity and disrupting telomere maintenance.	Lysine	116-122	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	54-59
22343013-10	2012	Tau reductions facilitated by DnaJA1 were dependent on the integrity of lysines known to be poly-ubiquitinated in human Alzheimer"s brain.	Lysine	72-79	DnaJ heat shock protein family (Hsp40) member A1	Homo sapiens	30-36
22659170-6	2012	AIRE with mutations that mimicked acetylated K243 and K253 in the SAND domain had reduced transactivation activity and accumulated into fewer and larger nuclear bodies, whereas mutations that mimicked the unacetylated lysines were functionally similar to wild-type AIRE.	Lysine	218-225	autoimmune regulator	Homo sapiens	0-4
22801502-3	2012	Here we show in mice and humans that the histone H3 methylated Lys 27 (H3K27) demethylase Utx (also known as Kdm6a) regulates the efficient induction, rather than maintenance, of pluripotency.	Lysine	63-66	lysine demethylase 6A	Homo sapiens	109-114
22793878-0	2012	Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin.	Lysine	97-103	albumin	Homo sapiens	136-149
22778253-7	2012	Here, we show that HDAC6 can be acetylated by p300 on five clusters of lysine residues.	Lysine	71-77	histone deacetylase 6	Homo sapiens	19-24
22732184-6	2012	In this regard, we and others have shown that MnSOD is regulated, at least in part, by the deacetylation of specific conserved lysines in a reaction catalyzed by the mitochondrial sirtuin, Sirt3.	Lysine	127-134	sirtuin 3	Homo sapiens	189-194
22847417-0	2012	Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.	Lysine	123-129	ubiquilin 1	Homo sapiens	0-11
22847417-0	2012	Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.	Lysine	123-129	amyloid beta precursor protein	Homo sapiens	22-47
22847419-4	2012	The Rossmann fold containing NAD(+) binding region on GAPDH is responsible for the interaction with TERC, whereas a lysine residue in the GAPDH catalytic domain is required for inhibiting telomerase activity and disrupting telomere maintenance.	Lysine	116-122	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	138-143
22847417-7	2012	These effects were mediated by ubiquilin-1-stimulated K63-linked polyubiquitination of lysine 688 in the APP intracellular domain.	Lysine	87-93	ubiquilin 1	Homo sapiens	31-42
22561048-10	2012	Similarly, xenin-25(Lys(13)PAL) potentiated (p&lt;0.05) the gluco-regulatory effect of (D-Ala(2))GIP.	Lysine	20-23	gastric inhibitory polypeptide	Mus musculus	97-100
22692198-4	2012	Here we show that, in the absence of Tyr-211 phosphorylation, PCNA is subject to polyubiquitylation at Lys-164 by the CUL4A E3 ligase, resulting in the degradation of PCNA.	Lysine	103-106	cullin 4A	Homo sapiens	118-123
22871331-2	2012	Polycomb group proteins EED, SUZ12, and EZH2 have been shown to mediate methylation of the lysine 27 residue of histone protein H3 (H3K27), an epigenetic mark that is linked with transcriptional repression.	Lysine	91-97	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	40-44
22871331-2	2012	Polycomb group proteins EED, SUZ12, and EZH2 have been shown to mediate methylation of the lysine 27 residue of histone protein H3 (H3K27), an epigenetic mark that is linked with transcriptional repression.	Lysine	91-97	H3 clustered histone 14	Homo sapiens	128-137
22798408-3	2012	Vernalization involves the epigenetic silencing of the floral repressor FLC via a conserved Polycomb (PRC2) mechanism involving trimethylation of Lys(27) on histone H3 (H3K27me3).	Lysine	146-149	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	72-75
22797359-8	2012	Immunodepletion of both tPA and lysine-binding proteins from bile fully abolished the lytic activity, suggesting that tPA and plasminogen present in human bile are responsible for the lysis-promoting effect.	Lysine	32-38	plasminogen activator, tissue type	Homo sapiens	118-121
22522052-3	2012	We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production.	Lysine	117-120	mitogen-activated protein kinase 3	Homo sapiens	309-315
22595241-1	2012	The Rtf1 subunit of the Paf1 complex is required for specific histone modifications, including histone H2B lysine 123 monoubiquitylation.	Lysine	107-113	Paf1p	Saccharomyces cerevisiae S288C	24-28
22372591-9	2012	However, cystine, lysine and tyrosine were shown to change in correlation with insulin sensitivity and high-density lipoprotein cholesterol levels in response to testosterone, indicating that those responses were somehow related to each other.	Lysine	18-24	insulin	Homo sapiens	79-86
22370893-2	2012	The histone H3 lysine 27 (H3K27) tri-methylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and is frequently up-regulated in human cancers.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	57-84
22370893-2	2012	The histone H3 lysine 27 (H3K27) tri-methylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and is frequently up-regulated in human cancers.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	86-90
22661693-9	2012	Significantly, the invariant lysine 55 residue was only essential for activity in the full-length PknK protein, and the truncated mutant proteins were active.	Lysine	29-35	serine/threonine-protein kinase PknK	Mycobacterium tuberculosis H37Rv	98-102
22505016-1	2012	Recently, we identified a somatic mutation in AKT1, which results in a glutamic acid to lysine substitution (p.Glu17Lys or E17K).	Lysine	88-94	AKT serine/threonine kinase 1	Homo sapiens	46-50
22547391-5	2012	PCAF associates with p27 through its catalytic domain and acetylates p27 at lysine 100.	Lysine	76-82	zinc ribbon domain containing 2	Homo sapiens	69-72
22467095-8	2012	5hmC increment following TET2 re-activation was associated with the reduction of histone H3 tri-methylation at lysine 9 (H3K9me3), which may contribute with DNA de-methylation reported elsewhere to recast a permissive epigenetic "landscape" for FoxO3a transcriptional activity.	Lysine	111-117	forkhead box O3	Homo sapiens	245-251
22622284-1	2012	Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a pivotal role in cancer stem cell (CSC) self-renewal through methylation of histone H3 lysine-27 (H3K27me3).	Lysine	214-220	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	78-105
22622284-1	2012	Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a pivotal role in cancer stem cell (CSC) self-renewal through methylation of histone H3 lysine-27 (H3K27me3).	Lysine	214-220	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	107-111
22645302-6	2012	Acetylated lysine 27 of histone 3 covered the HIF1 binding sites, and HIF1 functioned as an enhancer of SLC2A3 by interaction with lysine (K)-specific demethylase 3A (KDM3A).	Lysine	131-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-74
22579713-6	2012	GVS had a direct effect on the NFE2 promoters, as demonstrated by specific enrichment of associated histone H3 acetylated at lysine 9.	Lysine	125-131	nuclear factor, erythroid 2	Homo sapiens	31-35
22679021-0	2012	Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.	Lysine	19-22	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	120-125
22659026-3	2012	Analysis of two selected neuroprotective genes, iNOS and HIF-1alpha, showed marked increase in lysine 4 di-methylation and decrease in lysine 9 di-methylation of H3 histone.	Lysine	95-101	nitric oxide synthase 2	Rattus norvegicus	48-52
22659026-3	2012	Analysis of two selected neuroprotective genes, iNOS and HIF-1alpha, showed marked increase in lysine 4 di-methylation and decrease in lysine 9 di-methylation of H3 histone.	Lysine	135-141	nitric oxide synthase 2	Rattus norvegicus	48-52
22679021-3	2012	A deubiquitinating enzyme OTUB1 suppresses Lys-63-linked ubiquitination of chromatin surrounding DSBs by binding UBC13 to inhibit its E2 activity independently of the isopeptidase activity.	Lysine	43-46	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	26-31
22679021-4	2012	OTUB1 strongly suppresses UBC13-dependent Lys-63-linked tri-Ub production, whereas it allows di-Ub production in vitro.	Lysine	42-45	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	0-5
22679021-9	2012	The designed OTUB1 mutants cannot inhibit Lys-63-linked Ub chain formation in vitro and histone ubiquitination and 53BP1 assembly around DSB sites in vivo.	Lysine	42-45	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	13-18
22679021-10	2012	Finally, we propose a model for how capping of di-Ub by the OTUB1-UBC13-MMS2/UEV1a complex efficiently inhibits Lys-63-linked tri-Ub formation.	Lysine	112-115	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	60-65
22467861-10	2012	p39 had a greater propensity to accumulate in the nucleus than p35, and phosphorylation at Thr84, specific to p39, regulated the potential nuclear localization activity of the Lys cluster in p39.	Lysine	176-179	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	0-3
22683268-7	2012	We mapped the acetylation of H3 lysine 9 (H3K9ac) upon deletion of multiple subunits of Set3C and Rpd3(L)C and of ubH2B effectors.	Lysine	32-38	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	98-102
22669975-5	2012	Pellino 2 (but not Pellino 1) knockdown abolished IL-1- and LPS-induced Lys-63-linked IRAK1 ubiquitination with reduced Lys-48-linked IRAK1 ubiquitination.	Lysine	72-75	pellino E3 ubiquitin protein ligase family member 2	Homo sapiens	0-9
22669975-5	2012	Pellino 2 (but not Pellino 1) knockdown abolished IL-1- and LPS-induced Lys-63-linked IRAK1 ubiquitination with reduced Lys-48-linked IRAK1 ubiquitination.	Lysine	120-123	pellino E3 ubiquitin protein ligase family member 2	Homo sapiens	0-9
22536950-3	2012	G9a (also named euchromatin histone methyltransferase 2 (EHMT2)) catalyzes methylation of lysine 9 on histone H3 (H3K9), a modification linked to aberrant silencing of tumor-suppressor genes, among others.	Lysine	90-96	TSC complex subunit 1	Homo sapiens	168-184
22765480-13	2012	This lysine residue has been found to be critical for ACSL1 activity, and its modification has the potential to lead to biological consequences such as cardiac hypertrophy or thermogenesis dysregulation.	Lysine	5-11	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	54-59
22467861-10	2012	p39 had a greater propensity to accumulate in the nucleus than p35, and phosphorylation at Thr84, specific to p39, regulated the potential nuclear localization activity of the Lys cluster in p39.	Lysine	176-179	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	110-113
22467861-10	2012	p39 had a greater propensity to accumulate in the nucleus than p35, and phosphorylation at Thr84, specific to p39, regulated the potential nuclear localization activity of the Lys cluster in p39.	Lysine	176-179	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	110-113
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	tripartite motif containing 31	Homo sapiens	10-21
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Lysine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	140-153
22364122-5	2012	In particular, a glucose-lysine (Glu-Lys) mixture heated for 60 min had marked intracellular antioxidant activity and nitric oxide (NO) and interleukin-8 (IL-8) inhibitory activities compared to other MRPs (P &lt; 0.05).	Lysine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	tripartite motif containing 31	Homo sapiens	23-26
22820736-5	2012	However, whether lysine methylation plays a role in modulating FoxO3 activity has never been examined.	Lysine	17-23	forkhead box O3	Homo sapiens	63-68
22820736-7	2012	Using a combination of tandem mass spectrometry and methyl-specific antibodies, we find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1.	Lysine	136-142	forkhead box O3	Homo sapiens	109-114
22681518-1	2012	The maternally inherited 8344 A&gt;G mutation in the mitochondrial Lys tRNA is classically associated with the myoclonic epilepsy, ragged-red muscle fiber (MERRF) syndrome.	Lysine	67-70	mitochondrially encoded tRNA glycine	Homo sapiens	71-75
22731716-3	2012	Using an in vitro SUMOylation assay, we identified K218 as a conjugation site on claudin-2; mutation of that lysine to arginine blocked SUMOylation.	Lysine	109-115	claudin 2	Homo sapiens	81-90
22406003-0	2012	Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation.	Lysine	40-46	tumor necrosis factor	Homo sapiens	64-72
22406003-5	2012	Here we report that TNFalpha induces TAK1 Lys(48) linked polyubiquitination and degradation at the later time course.	Lysine	42-45	tumor necrosis factor	Homo sapiens	20-28
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	92-98	tumor necrosis factor	Homo sapiens	30-38
22406003-8	2012	As expected, TAK1 K72R mutation inhibits TNFalpha-induced Lys(48)-linked TAK1 polyubiquitination and degradation.	Lysine	58-61	tumor necrosis factor	Homo sapiens	41-49
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	92-98	tumor necrosis factor	Homo sapiens	203-211
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	47-50	tumor necrosis factor	Homo sapiens	30-38
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	47-50	tumor necrosis factor	Homo sapiens	203-211
22573887-3	2012	Binding of sAnk1.5 to KCTD6, and its subsequent turnover is regulated through posttranslational modification by nedd8, ubiquitin, and acetylation of C-terminal lysine residues.	Lysine	160-166	potassium channel tetramerization domain containing 6	Homo sapiens	22-27
22577163-6	2012	The enzyme modulation by C-peptide was abolished when C-terminal basic lysine residue (K434) of the enzyme was replaced by neutral alanine or acidic glutamate, but not with basic arginine.	Lysine	71-77	insulin	Homo sapiens	25-34
22577163-8	2012	Addition of a lysine analogue to the assay and A31 cell culture abrogated the enzyme modulation and MAP kinase activation by C-peptide, respectively.	Lysine	14-20	insulin	Homo sapiens	125-134
22532692-9	2012	More importantly, mutations of the arginine and lysine to alanine or glutamic acid in the receptor-binding region ablated the heparin-binding activity of apoE, as determined by an in vitro heparin pulldown assay.	Lysine	48-54	apolipoprotein E	Homo sapiens	154-158
22609005-4	2012	Thus high SCN(-) levels protect against HOCl- and MPO-mediated damage to methionine, tryptophan, lysine, histidine, and tyrosine residues on proteins.	Lysine	97-103	myeloperoxidase	Homo sapiens	50-53
22552582-1	2012	Acetylation of the tumor suppressor gene p53 at the carboxy-terminal lysine (Lys) residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis.	Lysine	69-75	tumor protein p53	Homo sapiens	41-44
22552582-1	2012	Acetylation of the tumor suppressor gene p53 at the carboxy-terminal lysine (Lys) residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis.	Lysine	77-80	tumor protein p53	Homo sapiens	41-44
22211425-5	2012	Sequence-based typing studies subsequently identified a G&gt;A mutation at Nucleotide 1960 (a glutamic acid &gt; lysine substitution at Position 628) in the 11th exon of the GPIIIa gene.	Lysine	113-119	integrin subunit beta 3	Homo sapiens	174-180
22600735-2	2012	Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification.	Lysine	26-32	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	178-181
22600735-2	2012	Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification.	Lysine	26-32	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	312-315
22600735-2	2012	Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification.	Lysine	147-153	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	178-181
22600735-2	2012	Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification.	Lysine	147-153	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	312-315
22600735-4	2012	In our previous study, we developed the acetylation set enrichment based (ASEB) computer program to predict which KAT-families are responsible for the acetylation of a given protein or lysine site.	Lysine	185-191	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	114-117
22476218-5	2012	Many genes that are responsive to this mutation in the HSI2 PHD-like domain are enriched in histone H3 trimethylation on lysine 27 residues (H3K27me3), a repressive epigenetic mark.	Lysine	121-127	B3 domain-containing transcription repressor VAL1	Arabidopsis thaliana	55-59
22498042-7	2012	Efficient retention of STIM1 in the ER during interphase depends on its lysine-rich domain and a di-arginine ER retention signal.	Lysine	72-78	stromal interaction molecule 1	Homo sapiens	23-28
22546239-9	2012	However, mutation of the Lys found in rat RAMP1 to Glu enhanced AM potency.	Lysine	25-28	receptor activity modifying protein 1	Rattus norvegicus	42-47
22792074-0	2012	FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.	Lysine	27-33	BTB domain and CNC homolog 1	Homo sapiens	6-11
22539352-1	2012	RAP80 (receptor-associated protein 80) is a ubiquitin-binding protein that can specifically recognize and bind to Lys-63-linked polyubiquitin chains, thus targeting the BRCA1-A complex to DNA damage sites.	Lysine	114-117	ubiquitin interaction motif containing 1	Mus musculus	0-5
22539352-1	2012	RAP80 (receptor-associated protein 80) is a ubiquitin-binding protein that can specifically recognize and bind to Lys-63-linked polyubiquitin chains, thus targeting the BRCA1-A complex to DNA damage sites.	Lysine	114-117	ubiquitin interaction motif containing 1	Mus musculus	7-37
22555612-2	2012	Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1.	Lysine	61-67	PR/SET domain 1	Homo sapiens	18-25
23213454-2	2012	Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains linked via lysine-48 as well as lysine-63 residues.	Lysine	94-100	ariadne RBR E3 ubiquitin protein ligase 2	Homo sapiens	0-6
22555612-3	2012	Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells.	Lysine	20-26	PR/SET domain 1	Homo sapiens	12-19
22555612-3	2012	Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells.	Lysine	20-26	histone deacetylase 2	Homo sapiens	134-139
22635276-5	2012	Mutation of the MDC1 Lys 1840 (K1840R) results in impaired CtIP, replication protein A, and Rad51 accumulation at sites of DNA damage and defective homologous recombination (HR).	Lysine	21-24	RB binding protein 8, endonuclease	Homo sapiens	59-63
22544757-5	2012	This YAP acetylation occurs on specific and highly conserved C-terminal lysine residues and is mediated by the nuclear acetyltransferases CBP (CREB binding protein) and p300.	Lysine	72-78	CREB binding protein	Homo sapiens	138-141
22544757-5	2012	This YAP acetylation occurs on specific and highly conserved C-terminal lysine residues and is mediated by the nuclear acetyltransferases CBP (CREB binding protein) and p300.	Lysine	72-78	CREB binding protein	Homo sapiens	143-163
23213454-2	2012	Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains linked via lysine-48 as well as lysine-63 residues.	Lysine	115-121	ariadne RBR E3 ubiquitin protein ligase 2	Homo sapiens	0-6
22681888-3	2012	We now report that one such modification, monoubiquitylation of histone H2B on lysine 120 (H2Bub1), catalyzed by the E3 ligase RNF20, increases during ESC differentiation and is required for efficient execution of this process.	Lysine	79-85	ring finger protein 20	Homo sapiens	127-132
22584054-4	2012	We identify a lysine residue of Bcd as the primary sumoylation site.	Lysine	14-20	bicoid	Drosophila melanogaster	32-35
22673569-4	2012	NIRF interacts with cyclins, CDKs, p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA.	Lysine	92-98	ubiquitin like with PHD and ring finger domains 2	Homo sapiens	0-4
22591353-2	2012	Because there is no tRNA-Dnmt2 cocrystal structure available, we have mapped the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants.	Lysine	151-157	tRNA aspartic acid methyltransferase 1	Homo sapiens	102-107
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	42-45	beta-secretase 1	Homo sapiens	101-106
22006429-7	2012	Notably, multiple mutations were identified in phosphoinositide-3-kinase (PI3K), catalytic, alpha polypeptide (PIK3CA) (H1047R, E lysine at codon 545 [E545K], and H proline at codon 701 [H701P]) that were not observed previously in osteosarcoma.	Lysine	130-136	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	111-117
22683789-1	2012	Aspartate-semialdehyde dehydrogenase (Asd; ASADH; EC 1.2.1.11) is the enzyme that lies at the first branch point in the biosynthetic pathway of important amino acids including lysine and methionine and the cell-wall component diaminopimelate (DAP).	Lysine	176-182	aspartate-semialdehyde dehydrogenase	Mycobacterium tuberculosis H37Rv	0-36
22722204-5	2012	Here we show that PGC7 protects 5mC from Tet3-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 lysine 9 (H3K9me2) in mice.	Lysine	142-148	tet methylcytosine dioxygenase 3	Mus musculus	41-45
22299711-0	2012	Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.	Lysine	0-3	beta-secretase 1	Homo sapiens	71-76
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	42-45	amyloid beta precursor protein	Homo sapiens	152-157
22299711-0	2012	Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.	Lysine	13-16	beta-secretase 1	Homo sapiens	71-76
22273601-3	2012	Signals comparable to those obtained with BSA were observed with poly(L-Trp, L-Lys), poly(L-Trp, L-Arg) or poly(L-Trp, L-Orn) at pH 7.0.	Lysine	77-82	albumin	Homo sapiens	42-45
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	29-32	beta-secretase 1	Homo sapiens	54-59
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	29-32	beta-secretase 1	Homo sapiens	101-106
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	29-32	amyloid beta precursor protein	Homo sapiens	152-157
22299711-9	2012	Site-directed mutagenesis at Lys(203) and Lys(382) of BACE1 abolished the proteasomal degradation of BACE1 and affected APP processing at beta site and Abeta production.	Lysine	42-45	beta-secretase 1	Homo sapiens	54-59
22493065-0	2012	Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.	Lysine	112-118	Utx histone demethylase	Drosophila melanogaster	20-23
22484288-8	2012	In addition, this His--&gt;Lys variant exhibited potent growth inhibitory activity (ID(50) 25-40 mum) against several human cancer cell lines and endothelial cells that was absent in both natural peptides.	Lysine	27-30	latexin	Homo sapiens	97-100
22273601-9	2012	As a matter of fact, HSA and BSA contain an internal tryptophan in close proximity to lysine and arginine residues and therefore suitable for pi-cation interactions.	Lysine	86-92	albumin	Homo sapiens	29-32
22273601-12	2012	Based on preliminary results that have shown that LIOAS signal at 532 nm depended on the aggregation state of BSA and/or on the oxidation state of its Cys-34, we postulate that the LIOAS signal observed with proteins and tryptophan-containing polypeptides are related to Trp-Lys or Trp-Arg interactions and that the intensity of the signal depends on the strength of such interactions.	Lysine	275-278	albumin	Homo sapiens	110-113
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-88
22419549-4	2012	Lysine acetylation involves the loss of favorable electrostatic interactions between DNA and NF-kappaB, which is partially compensated by the reduction of the desolvation free-energy of the two binding partners.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	93-102
22547799-2	2012	Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors.	Lysine	21-27	signal transducer and activator of transcription 3	Homo sapiens	78-83
22592635-7	2012	To investigate the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt, a group of rats was subjected to pretreatment with an inhibitor of PI3K/Akt (LY 29004, 3 mg/kg i.p.)	Lysine	153-155	AKT serine/threonine kinase 1	Rattus norvegicus	148-151
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	97-103	vascular endothelial growth factor A	Homo sapiens	22-26
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	97-103	vascular endothelial growth factor A	Homo sapiens	218-252
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	97-103	vascular endothelial growth factor A	Homo sapiens	254-258
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	194-200	vascular endothelial growth factor A	Homo sapiens	22-26
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	194-200	vascular endothelial growth factor A	Homo sapiens	218-252
22537066-10	2012	We employed a peptide-VEGF model system to discover that a 19mer peptide ligand, which carried a lysine-tagged dinitrofluorobenzene group, became attached stably and with good yield to a unique lysine residue on human vascular endothelial growth factor (VEGF), even in the presence of 70% fetal bovine serum.	Lysine	194-200	vascular endothelial growth factor A	Homo sapiens	254-258
22408254-7	2012	Mutation of lysine 19 in recombinant hGLYATL2 to glutamine (K19Q) and arginine (K19R) resulted in a 50-80% lower production of N-oleoyl glycine and N-arachidonoylglycine, indicating that lysine 19 is important for enzyme function.	Lysine	12-18	glycine-N-acyltransferase like 2	Homo sapiens	37-45
22541069-6	2012	DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.	Lysine	87-93	D4Z4 binding element transcript	Homo sapiens	0-5
22408254-7	2012	Mutation of lysine 19 in recombinant hGLYATL2 to glutamine (K19Q) and arginine (K19R) resulted in a 50-80% lower production of N-oleoyl glycine and N-arachidonoylglycine, indicating that lysine 19 is important for enzyme function.	Lysine	187-193	glycine-N-acyltransferase like 2	Homo sapiens	37-45
22483618-0	2012	Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.	Lysine	32-38	lysyl oxidase like 2	Homo sapiens	0-20
22408254-0	2012	Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules.	Lysine	11-17	glycine-N-acyltransferase like 2	Homo sapiens	58-90
22408254-0	2012	Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules.	Lysine	11-17	glycine-N-acyltransferase like 2	Homo sapiens	92-100
22408254-6	2012	Lysine 19 is a conserved residue in human glycine N-acyltransferase-like 2 (hGLYATL2) and in several other species, showing that this residue may be important for enzyme function.	Lysine	0-6	glycine-N-acyltransferase like 2	Homo sapiens	42-74
22408254-11	2012	In conclusion, acetylation of lysine(s) in hGLYATL2 regulates the enzyme activity, thus linking post-translational modification of proteins with the production of biological signaling molecules, the N-acyl glycines.	Lysine	30-36	glycine-N-acyltransferase like 2	Homo sapiens	43-51
22408254-6	2012	Lysine 19 is a conserved residue in human glycine N-acyltransferase-like 2 (hGLYATL2) and in several other species, showing that this residue may be important for enzyme function.	Lysine	0-6	glycine-N-acyltransferase like 2	Homo sapiens	76-84
22507986-0	2012	Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: a mass spectrometric and isotope labeling study.	Lysine	67-73	fibrinogen beta chain	Homo sapiens	29-39
22578539-2	2012	(2012) demonstrate that LOXL2 deaminates trimethylated histone 3 lysine 4 (H3K4me3), which uncovers a new chromatin modification and a new enzymatic mechanism with the potential to regulate additional lysine residues.	Lysine	65-71	lysyl oxidase like 2	Homo sapiens	24-29
22578539-2	2012	(2012) demonstrate that LOXL2 deaminates trimethylated histone 3 lysine 4 (H3K4me3), which uncovers a new chromatin modification and a new enzymatic mechanism with the potential to regulate additional lysine residues.	Lysine	201-207	lysyl oxidase like 2	Homo sapiens	24-29
22507986-11	2012	Thus, fibrinogen is acetylated at several lysine residues, some of which are involved in the cross-linking of fibrinogen.	Lysine	42-48	fibrinogen beta chain	Homo sapiens	6-16
22507986-11	2012	Thus, fibrinogen is acetylated at several lysine residues, some of which are involved in the cross-linking of fibrinogen.	Lysine	42-48	fibrinogen beta chain	Homo sapiens	110-120
22301686-1	2012	AIMS: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver.	Lysine	115-121	nitric oxide synthase 2	Rattus norvegicus	217-248
21963854-6	2012	p53 pre-methylated at lysine-372 (p53K372 mono-methylation) by SET7 protects p53 from E6-induced degradation.	Lysine	22-28	tumor protein p53	Homo sapiens	0-3
21963854-6	2012	p53 pre-methylated at lysine-372 (p53K372 mono-methylation) by SET7 protects p53 from E6-induced degradation.	Lysine	22-28	tumor protein p53	Homo sapiens	34-37
22301686-1	2012	AIMS: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver.	Lysine	115-121	nitric oxide synthase 2	Rattus norvegicus	250-254
22207202-0	2012	Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.	Lysine	56-62	CREB binding protein	Homo sapiens	108-116
21926398-3	2012	PcG member EZH2 mediates gene silencing through histone-H3 lysine-27 methylation.	Lysine	59-65	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	11-15
22207202-7	2012	Here, we use mutagenesis to show that a lysine residue at position 34 within AD1 of E12/E47 is acetylated by CBP/p300 and PCAF.	Lysine	40-46	amyloid beta precursor protein	Homo sapiens	77-80
22207202-7	2012	Here, we use mutagenesis to show that a lysine residue at position 34 within AD1 of E12/E47 is acetylated by CBP/p300 and PCAF.	Lysine	40-46	CREB binding protein	Homo sapiens	109-117
22378382-2	2012	FLC activation by FRI is accompanied by an increase in specific histone modifications, such as tri-methylation of histone H3 at lysine 4 (H3K4me3), and requires three H3K4 methyltransferases, the Drosophila Trithorax-class Arabidopsis trithorax1 (ATX1) and ATX2, and yeast Set1-class ATX-related7/set domain group25 (ATXR7/SDG25).	Lysine	128-134	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	0-3
22309213-1	2012	SIRT3 (sirtuin 3) modulates respiration via the deacetylation of lysine residues in electron transport chain proteins.	Lysine	65-71	sirtuin 3	Homo sapiens	0-5
22309213-1	2012	SIRT3 (sirtuin 3) modulates respiration via the deacetylation of lysine residues in electron transport chain proteins.	Lysine	65-71	sirtuin 3	Homo sapiens	7-16
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	127-131
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	140-145
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	147-152
22357270-5	2012	Gene repression by EBNA 3C was accompanied by decreased histone H3 lysine 9/14 acetylation and increased histone H3 lysine 27 trimethylation.	Lysine	67-73	EBNA-3C	Human gammaherpesvirus 4	19-26
22357270-5	2012	Gene repression by EBNA 3C was accompanied by decreased histone H3 lysine 9/14 acetylation and increased histone H3 lysine 27 trimethylation.	Lysine	116-122	EBNA-3C	Human gammaherpesvirus 4	19-26
22311776-5	2012	We show that changes of lysine residues of the NLS (Nuclear Localization Signal) sequence of CRY2 to arginine residues partially impair the nuclear importation of the CRY2K541R and CRY2K554/5R mutant proteins, resulting in reduced phosphorylation, physiological activities, and degradation in response to blue light.	Lysine	24-30	cryptochrome 2	Arabidopsis thaliana	93-97
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c, somatic	Homo sapiens	19-31
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c, somatic	Homo sapiens	182-194
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c, somatic	Homo sapiens	182-194
22549955-1	2012	Monoubiquitination of histone H2B on Lys 123 (H2BK123ub) is a transient histone modification considered to be essential for establishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.	Lysine	37-40	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	170-174
22549955-1	2012	Monoubiquitination of histone H2B on Lys 123 (H2BK123ub) is a transient histone modification considered to be essential for establishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.	Lysine	37-40	DOT1 like histone lysine methyltransferase	Homo sapiens	187-191
22445450-9	2012	In the striatum, Lys administration provoked a marked increase of lipid peroxidation, DCFH oxidation, SOD and GR activities, as well as significant reductions of GSH levels and GPx activity, with no alteration of sulfhydryl content, CAT and G6PD activities.	Lysine	17-20	catalase	Mus musculus	233-236
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	31-37	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	16-20
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	31-37	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	88-93
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	31-37	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	98-103
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	144-147	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	16-20
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	144-147	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	88-93
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	144-147	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	98-103
22266653-7	2012	Overall, our findings illustrate the function of WDR5 in scaffolding the SET1 family of KMTs and further emphasize on the important role of WDR5 in regulating global histone H3 Lys-4 methylation.	Lysine	177-180	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	73-77
22266653-7	2012	Overall, our findings illustrate the function of WDR5 in scaffolding the SET1 family of KMTs and further emphasize on the important role of WDR5 in regulating global histone H3 Lys-4 methylation.	Lysine	177-180	WD repeat domain 5	Homo sapiens	140-144
22483804-2	2012	In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1-MLL4) whose specific functions are largely unknown.	Lysine	30-36	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	158-163
22483804-2	2012	In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1-MLL4) whose specific functions are largely unknown.	Lysine	30-36	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	168-173
22237799-6	2012	We show here that metanephric p53 is phosphorylated and acetylated on key serine and lysine residues, respectively, in a temporal profile which correlates with the maturational changes in total p53 levels and DNA-binding activity.	Lysine	85-91	tumor protein p53	Homo sapiens	30-33
21892211-4	2012	Binding of EZH2 to the 5"-end of KLF2 is also associated with a gain of trimethylated lysine 27 histone H3 and a depletion of phosphorylated serine 2 of RNA polymerase.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	11-15
21892211-4	2012	Binding of EZH2 to the 5"-end of KLF2 is also associated with a gain of trimethylated lysine 27 histone H3 and a depletion of phosphorylated serine 2 of RNA polymerase.	Lysine	86-92	Kruppel like factor 2	Homo sapiens	33-37
22500771-3	2012	In the recent solution NMR structure of the DAP12-NKG2C immunoreceptor transmembrane helix complex, five functionally required interfacial residues (two Asps and two Thrs in the DAP12 dimer and one Lys in NKG2C) display a surprising arrangement in which one Asp side chain faces the membrane hydrophobic core.	Lysine	198-201	killer cell lectin like receptor C2	Homo sapiens	50-55
22451931-5	2012	Cellular expression of caspase-7 lacking the critical lysine residues resulted in less-efficient PARP and p23 cleavage compared with cells expressing the wild-type peptidase.	Lysine	54-60	poly(ADP-ribose) polymerase 1	Homo sapiens	97-101
22412156-0	2012	Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.	Lysine	11-17	interferon alpha 1	Homo sapiens	69-79
22412156-4	2012	We identify di-methylation of histone H3 at lysine 9 (H3K9me2) as a suppressor of IFN and IFN-inducible antiviral gene expression.	Lysine	44-50	interferon alpha 1	Homo sapiens	82-85
22412156-4	2012	We identify di-methylation of histone H3 at lysine 9 (H3K9me2) as a suppressor of IFN and IFN-inducible antiviral gene expression.	Lysine	44-50	interferon alpha 1	Homo sapiens	90-93
22181833-3	2012	We have used four representative CR domains from the principal ligand-binding cluster of LRP to determine the energetics of interaction with well-defined small ligands that include methyl esters of lysine, arginine, histidine and aspartate, as well as N-terminally blocked lysine methyl ester.	Lysine	198-204	LDL receptor related protein 1	Homo sapiens	89-92
22320423-0	2012	Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multidrug-resistant cells.	Lysine	18-24	ATP binding cassette subfamily B member 1	Homo sapiens	56-60
22320423-4	2012	By studying a breast carcinoma model cell line and its MDR1-overexpressing derivative, we show that the histone 3 lysine 9 (H3K9) acetylation level is elevated 100-fold in the promoter and first exon of the MDR1 gene in the drug-resistant cell line compared to the drug-sensitive cell line.	Lysine	114-120	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
22320423-4	2012	By studying a breast carcinoma model cell line and its MDR1-overexpressing derivative, we show that the histone 3 lysine 9 (H3K9) acetylation level is elevated 100-fold in the promoter and first exon of the MDR1 gene in the drug-resistant cell line compared to the drug-sensitive cell line.	Lysine	114-120	ATP binding cassette subfamily B member 1	Homo sapiens	207-211
22320423-5	2012	The acetylation level of the other examined lysine residues (H3K4, H3K14, H4K8, and H4K12) is weakly or not at all elevated in the MDR1 locus, although their acetylation is generally increased genome-wide in the drug-resistant cell.	Lysine	44-50	ATP binding cassette subfamily B member 1	Homo sapiens	131-135
22252741-8	2012	In addition, chromatin immunoprecipitation revealed that JMJD3-kd could inhibit several NF-kappaB-regulated inflammatory genes by recruiting repressive histone-3 lysine-27 trimethylation to their promoters.	Lysine	162-168	nuclear factor kappa B subunit 1	Homo sapiens	88-97
22402663-0	2012	Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death.	Lysine	0-6	forkhead box O3	Homo sapiens	22-27
22476432-2	2012	In mammals, histone H3 lysine 9 (H3K9)-specific histone methyltransferases (HMTases), such as G9a, SETDB1, and SUV39H, play critical roles, but the contribution of H3K9-specific HMTases in Drosophila remains to be clarified, especially in male sperm.	Lysine	23-29	eggless	Drosophila melanogaster	99-105
22402663-3	2012	Here, we demonstrate that the methyltransferase Set9 methylates FOXO3 at lysine 270.	Lysine	73-79	forkhead box O3	Homo sapiens	64-69
22406531-5	2012	Here, we have determined that methylation of histone H3 on lysine 9 (H3K9me2) is critical for promoter DNA methylation of E-cadherin in three TGF-beta-induced EMT model cell lines, as well as in CLBC cell lines.	Lysine	59-65	cadherin 1	Homo sapiens	122-132
22402663-5	2012	Accordingly, lysine methylation reduces oxidative stress-induced and FOXO3-mediated Bim expression and neuronal apoptosis in neurons.	Lysine	13-19	forkhead box O3	Homo sapiens	69-74
22402663-6	2012	Collectively, these findings define a novel modification of FOXO3 and show that lysine methylation negatively regulates FOXO3-mediated transcription and neuronal apoptosis.	Lysine	80-86	forkhead box O3	Homo sapiens	60-65
22402663-6	2012	Collectively, these findings define a novel modification of FOXO3 and show that lysine methylation negatively regulates FOXO3-mediated transcription and neuronal apoptosis.	Lysine	80-86	forkhead box O3	Homo sapiens	120-125
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Lysine	88-91	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
20978925-8	2012	CG200745 increased acetylation of p53 lysine residues K320, K373, and K382.	Lysine	38-44	tumor protein p53	Homo sapiens	34-37
22406531-5	2012	Here, we have determined that methylation of histone H3 on lysine 9 (H3K9me2) is critical for promoter DNA methylation of E-cadherin in three TGF-beta-induced EMT model cell lines, as well as in CLBC cell lines.	Lysine	59-65	A-kinase anchoring protein 13	Homo sapiens	195-199
22689617-1	2012	Mass spectrometry was used to probe the preferred locations of trans-4-hydroxy-2-nonenal (HNE) addition to the cysteine, histidine, and lysine residues of human serum albumin (HSA).	Lysine	136-142	albumin	Homo sapiens	161-174
22569052-11	2012	OPSCC tumours positive for p16 had global elevations of histone H4 monomethylated lysine 20 (H4K20me1) and H3 trimethylated lysine 27 (H3K27me3) with depletions of H4 trimethylated lysine 20 (H4K20me3).	Lysine	82-88	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-30
22569052-11	2012	OPSCC tumours positive for p16 had global elevations of histone H4 monomethylated lysine 20 (H4K20me1) and H3 trimethylated lysine 27 (H3K27me3) with depletions of H4 trimethylated lysine 20 (H4K20me3).	Lysine	124-130	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-30
22569052-11	2012	OPSCC tumours positive for p16 had global elevations of histone H4 monomethylated lysine 20 (H4K20me1) and H3 trimethylated lysine 27 (H3K27me3) with depletions of H4 trimethylated lysine 20 (H4K20me3).	Lysine	124-130	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-30
21979880-4	2012	SUV39H1, the main methyl-transferase for lysine 9 tri-methylation on histone H3, interacts with oncogenes involved in AML and acts as a transcriptional repressor for hematopoietic differentiation and immortalization.	Lysine	41-47	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
22334682-9	2012	The acetylation of this lysine also affects the stability of API5 in cells.	Lysine	24-30	apoptosis inhibitor 5	Homo sapiens	61-65
22298428-5	2012	Ankrd 13 proteins bound specifically to Lys-63-linked ubiquitin chains, which was consistent with a previous report that EGFR mainly undergoes Lys-63-linked polyubiquitination.	Lysine	40-43	epidermal growth factor receptor	Homo sapiens	121-125
22298428-5	2012	Ankrd 13 proteins bound specifically to Lys-63-linked ubiquitin chains, which was consistent with a previous report that EGFR mainly undergoes Lys-63-linked polyubiquitination.	Lysine	143-146	epidermal growth factor receptor	Homo sapiens	121-125
22298428-8	2012	We conclude that by binding to the Lys-63-linked polyubiquitin moiety of EGFR at the plasma membrane, Ankrd 13 proteins regulate the rapid internalization of ligand-activated EGFR.	Lysine	35-38	epidermal growth factor receptor	Homo sapiens	73-77
22298428-8	2012	We conclude that by binding to the Lys-63-linked polyubiquitin moiety of EGFR at the plasma membrane, Ankrd 13 proteins regulate the rapid internalization of ligand-activated EGFR.	Lysine	35-38	epidermal growth factor receptor	Homo sapiens	175-179
22522802-7	2012	Methyltransferase Rkm1 was found to monomethylate 40S ribosomal protein S18-A/B at lysine 48.	Lysine	83-89	protein-lysine N-methyltransferase	Saccharomyces cerevisiae S288C	18-22
22300764-0	2012	CNP-1 (ARRD-17), a novel substrate of calcineurin, is critical for modulation of egg-laying and locomotion in response to food and lysine sensation in Caenorhabditis elegans.	Lysine	131-137	Arrestin domain-containing protein 17	Caenorhabditis elegans	7-14
22479715-0	2004	(18)F-Fluoroethyl triazole-betaAG-[(d)-Phe(1)-c(Cys(2)-Tyr(3)-(d)-Trp(4)-Lys(5)-Thr(6)-Cys(7))Thr(8)] The (18)F-labeled fluoroethyl triazole (FET)-betaAG-[(d)-Phe(1)-c(Cys(2)-Tyr(3)-(d)-Trp(4)-Lys(5)-Thr(6)-Cys(7))Thr(8)] (TOCA or Tyr(3)-octreotide), abbreviated as (18)F-FET-betaAG-TOCA, is a Tyr(3)-octreotate analog that was synthesized for positron emission tomography of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) by targeting somatostatin receptors (SSTR, mainly SSTR-2) (1, 2).	Lysine	73-76	granulin precursor	Homo sapiens	422-425
22479715-0	2004	(18)F-Fluoroethyl triazole-betaAG-[(d)-Phe(1)-c(Cys(2)-Tyr(3)-(d)-Trp(4)-Lys(5)-Thr(6)-Cys(7))Thr(8)] The (18)F-labeled fluoroethyl triazole (FET)-betaAG-[(d)-Phe(1)-c(Cys(2)-Tyr(3)-(d)-Trp(4)-Lys(5)-Thr(6)-Cys(7))Thr(8)] (TOCA or Tyr(3)-octreotide), abbreviated as (18)F-FET-betaAG-TOCA, is a Tyr(3)-octreotate analog that was synthesized for positron emission tomography of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) by targeting somatostatin receptors (SSTR, mainly SSTR-2) (1, 2).	Lysine	73-76	somatostatin receptor 2	Homo sapiens	482-488
21837672-1	2012	BACKGROUND: Enhancer of zeste homolog 2 (EZH2) epigenetically silences many genes through the trimethylation of histone H3 lysine 27 and is implicated in tumor growth, invasion, and metastasis.	Lysine	123-129	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	12-39
22440088-4	2012	DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a pathway that controls methylation of the histone H3 globular domain at lysine 79 (H3K79), thereby modulating expression of the ENaCalpha subunit.	Lysine	119-125	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
22440088-4	2012	DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a pathway that controls methylation of the histone H3 globular domain at lysine 79 (H3K79), thereby modulating expression of the ENaCalpha subunit.	Lysine	119-125	MLLT3 super elongation complex subunit	Homo sapiens	7-12
22440088-4	2012	DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a pathway that controls methylation of the histone H3 globular domain at lysine 79 (H3K79), thereby modulating expression of the ENaCalpha subunit.	Lysine	119-125	sodium channel epithelial 1 subunit alpha	Homo sapiens	175-184
22275358-3	2012	The interaction of rhodopsin-attached phosphates with Lys-14 and Lys-15 in beta-strand I was shown to disrupt the interaction of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition into an active receptor-binding state.	Lysine	54-57	rhodopsin	Homo sapiens	19-28
22275358-3	2012	The interaction of rhodopsin-attached phosphates with Lys-14 and Lys-15 in beta-strand I was shown to disrupt the interaction of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition into an active receptor-binding state.	Lysine	65-68	rhodopsin	Homo sapiens	19-28
22267743-7	2012	Further mutational analysis identified Lys(157) within the putative NLS as being critical to nuclear localization of beta-arrestin-1.	Lysine	39-42	arrestin beta 1	Homo sapiens	117-132
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	44-50	forkhead box O3	Homo sapiens	91-96
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	44-50	forkhead box O3	Homo sapiens	134-139
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	44-50	forkhead box O3	Homo sapiens	134-139
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	264-270	forkhead box O3	Homo sapiens	91-96
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	264-270	forkhead box O3	Homo sapiens	134-139
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	264-270	forkhead box O3	Homo sapiens	134-139
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	102-108	calmodulin 1	Homo sapiens	30-33
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	102-108	estrogen receptor 1	Homo sapiens	121-129
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	102-108	estrogen receptor 1	Homo sapiens	251-259
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	131-134	calmodulin 1	Homo sapiens	30-33
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	131-134	estrogen receptor 1	Homo sapiens	121-129
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	131-134	estrogen receptor 1	Homo sapiens	251-259
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	141-144	calmodulin 1	Homo sapiens	30-33
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	141-144	estrogen receptor 1	Homo sapiens	121-129
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	141-144	calmodulin 1	Homo sapiens	30-33
22275375-6	2012	Exposed glutamate residues in CaM (Glu(11), Glu(14), Glu(84), and Glu(87)) form salt bridges with key lysine residues in ER-alpha (Lys(299), Lys(302), and Lys(303)), which are likely to prevent ubiquitination at these sites and inhibit degradation of ER-alpha.	Lysine	141-144	estrogen receptor 1	Homo sapiens	121-129
21837672-1	2012	BACKGROUND: Enhancer of zeste homolog 2 (EZH2) epigenetically silences many genes through the trimethylation of histone H3 lysine 27 and is implicated in tumor growth, invasion, and metastasis.	Lysine	123-129	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	41-45
22267734-1	2012	The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (Abeta), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.	Lysine	217-223	beta-secretase 1	Homo sapiens	23-54
22267734-1	2012	The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (Abeta), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.	Lysine	217-223	beta-secretase 1	Homo sapiens	56-61
22267734-1	2012	The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (Abeta), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.	Lysine	217-223	amyloid beta precursor protein	Homo sapiens	160-165
22285752-4	2012	In other cells without adenovirus expression, the C-terminal domain of WTX binds to the DNA-binding domain of p53, enhances its binding to CBP, and increases CBP/p300-mediated acetylation of p53 at Lys 373/382.	Lysine	198-201	CREB binding protein	Homo sapiens	158-166
22285752-4	2012	In other cells without adenovirus expression, the C-terminal domain of WTX binds to the DNA-binding domain of p53, enhances its binding to CBP, and increases CBP/p300-mediated acetylation of p53 at Lys 373/382.	Lysine	198-201	tumor protein p53	Homo sapiens	191-194
22267734-1	2012	The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (Abeta), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.	Lysine	217-223	N-acetyltransferase 8 (putative)	Homo sapiens	255-261
22232552-3	2012	Thus Ala substitution of Lys(513), Lys(516), Glu(521), and Glu(535) all cause misfolding of MRP1 and target the protein for proteasome-mediated degradation.	Lysine	25-28	ATP binding cassette subfamily C member 1	Homo sapiens	92-96
22205704-11	2012	Well conserved residues were highlighted, and the potential strategic role of the lysine 31 residue of AvBD2 was emphasized.	Lysine	82-88	defensin beta 4A	Gallus gallus	103-108
22249179-5	2012	However, TIP60 maintained acetylated Lys-310 RelA/p65 levels in the TNF-alpha-dependent NF-kappaB signaling pathway.	Lysine	37-40	tumor necrosis factor	Homo sapiens	68-77
22227389-1	2012	Human tRNA(Lys3)(UUU) (htRNA(Lys3)(UUU)) decodes the lysine codons AAA and AAG during translation and also plays a crucial role as the primer for HIV-1 (human immunodeficiency virus type 1) reverse transcription.	Lysine	53-59	mitochondrially encoded tRNA glycine	Homo sapiens	6-15
22144423-2	2012	EZH2 silences gene expression through trimethylating lysine 27 on histone H3 (H3K27Me3).	Lysine	53-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
22178192-8	2012	Tandem mass spectrometric analyses revealed that these reactive carbonyls target specific Lys residues in the C-terminus of apoA-I.	Lysine	90-93	apolipoprotein A1	Homo sapiens	124-130
21749932-0	2012	Lysine residues of ABCA1 are required for the interaction with apoA-I.	Lysine	0-6	apolipoprotein A1	Homo sapiens	63-69
21749932-5	2012	The apoA-I binding to ABCA1 and the cross-linking between them were inhibited by the highly charged molecules heparin and poly-L-lysine.	Lysine	122-135	apolipoprotein A1	Homo sapiens	4-10
21749932-8	2012	These results suggest that lysine residues in the extracellular domains of ABCA1 contribute to the interaction with apoA-I.	Lysine	27-33	apolipoprotein A1	Homo sapiens	116-122
22185822-5	2012	Moreover, we found that XIAP-induced ubiquitination and degradation is prevented by removal of the first four amino acids in the N-terminus of ARTS, which contains a single lysine residue at position 3.	Lysine	173-179	septin 4	Homo sapiens	143-147
22435549-1	2012	A role for polyubiquitination in the activation of inhibitor of NF-kappaB (IkappaB) kinase (IKK) through a proteasome-independent mechanism was first reported in 1996, but the physiological significance of this finding was not clear until 2000 when TRAF6 was found to be a ubiquitin E3 ligase that catalyzes lysine-63 (K63) polyubiquitination.	Lysine	308-314	nuclear factor kappa B subunit 1	Homo sapiens	64-90
22284438-9	2012	Additional studies performed on UCHL3 by mutating the Gln to Glu (strong C-H   O acceptor but oxyanion destabilizer) and to Lys (strong oxyanion stabilizer but lacking C-H   O hydrogen-bonding capability) suggest that the C-H   O hydrogen bond could contribute to catalysis.	Lysine	124-127	ubiquitin C-terminal hydrolase L3	Homo sapiens	32-37
22184422-7	2012	Dentilisin was found to inactivate LL-37 by cleaving it at the Lys, Phe, Gln, and Val residues.	Lysine	63-66	cathelicidin antimicrobial peptide	Homo sapiens	35-40
22213354-0	2012	Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry.	Lysine	16-22	fibrinogen beta chain	Homo sapiens	65-75
22213354-2	2012	To test this hypothesis, mass spectrometric methods were developed to quantify chemical modification of lysine residues following adsorption of fibrinogen to biomaterials.	Lysine	104-110	fibrinogen beta chain	Homo sapiens	144-154
21841824-8	2012	This binding activates a series of repressive histone modification marks including histone 3 lysine 27 trimethylation (H3K27me3) to make the changes stable, and if overturned reduces CCRCC cell proliferation due to excessive HIF-1alpha expression level.	Lysine	93-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	225-235
22320917-1	2012	BACKGROUND AND AIM: Transglutaminase 2 (TG2), catalyzing crosslinking between lysine and glutamine residues, is involved in many liver diseases.	Lysine	78-84	transglutaminase 2	Homo sapiens	20-38
22320917-1	2012	BACKGROUND AND AIM: Transglutaminase 2 (TG2), catalyzing crosslinking between lysine and glutamine residues, is involved in many liver diseases.	Lysine	78-84	transglutaminase 2	Homo sapiens	40-43
22252319-4	2012	Rather, by promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.	Lysine	33-39	Paf1p	Saccharomyces cerevisiae S288C	60-64
22279139-7	2012	Subsequent chromatin immunoprecipitation analysis further demonstrated that the binding of p300/CBP-associated factor, a coactivator of SREBP-1c, and histone H3 lysine 14 acetylation at the FAS, SCD1, and ACC1 promoters were significantly reduced in the livers of APOE2 mice and HepG2 cells treated with MOEO compared with their controls.	Lysine	161-167	apolipoprotein E	Homo sapiens	264-269
22323599-0	2012	Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).	Lysine	122-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	46-50
22308438-6	2012	We cross-linked TRiC under native conditions with a cross-linker that is primarily reactive toward exposed lysine side chains that are spatially close in the context of the particle.	Lysine	107-113	MARVEL domain containing 2	Homo sapiens	16-20
22323599-1	2012	Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational modification mediated by the histone methyltransferase EZH2.	Lysine	32-38	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	142-146
22323599-9	2012	Structural modeling of WT and mutant EZH2 suggested that the A677G mutation acquires the ability to methylate H3K27me2 through enlargement of the lysine tunnel while preserving activity with H3K27me0/me1 substrates through retention of the Y641 residue that is crucial for orientation of these smaller substrates.	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	37-41
22262660-3	2012	In this study, we evaluated the effects of airway activation of FPRs by their synthetic agonist, Trp-Lys-Tyr-Met-Val-D-Met (W-peptide), on the development of Th1 and Th17 cell responses in a noneosinophilic asthma mouse model.	Lysine	101-104	negative elongation factor complex member C/D, Th1l	Mus musculus	158-161
22190683-1	2012	Dot1-like protein (DOT1L) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 of histone H3 (H3K79).	Lysine	99-105	DOT1 like histone lysine methyltransferase	Homo sapiens	0-17
22190683-1	2012	Dot1-like protein (DOT1L) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 of histone H3 (H3K79).	Lysine	99-105	DOT1 like histone lysine methyltransferase	Homo sapiens	19-24
22242891-0	2012	Improved synthesis of lysine- and arginine-derived Amadori and Heyns products and in vitro measurement of their angiotensin I-converting enzyme inhibitory activity.	Lysine	22-28	angiotensin I converting enzyme	Homo sapiens	112-143
22868801-8	2012	Nepsilon-Hcy-Lys levels correlated with PON1 (r=-0.62, p&lt;0.0001), ADMA (r=0.58, p&lt;0.0001) and PAI-1 (r=0.59, p&lt;0.0001).	Lysine	13-16	paraoxonase 1	Homo sapiens	40-44
21518270-5	2012	All TRPC channels have a Homer-binding ligand and two conserved negative charges that interact with two terminal lysines of the stromal interacting molecule 1 (STIM1).	Lysine	113-120	stromal interaction molecule 1	Homo sapiens	128-158
22224594-1	2012	Tissue transglutaminase 2 (TG2) is a multifunctional protein primarily known for its calcium-dependent enzymatic protein cross-linking activity via isopeptide bond formation between glutamine and lysine residues.	Lysine	196-202	transglutaminase 2	Homo sapiens	27-30
22053931-8	2012	Mutation of this site thus inhibited ubiquitylation of and stabilized p27(Kip1), suggesting that this lysine residue is the target site of p27(Kip1) for ubiquitin conjugation in vivo.	Lysine	102-108	zinc ribbon domain containing 2	Homo sapiens	70-73
22053931-8	2012	Mutation of this site thus inhibited ubiquitylation of and stabilized p27(Kip1), suggesting that this lysine residue is the target site of p27(Kip1) for ubiquitin conjugation in vivo.	Lysine	102-108	zinc ribbon domain containing 2	Homo sapiens	139-142
21518270-5	2012	All TRPC channels have a Homer-binding ligand and two conserved negative charges that interact with two terminal lysines of the stromal interacting molecule 1 (STIM1).	Lysine	113-120	stromal interaction molecule 1	Homo sapiens	160-165
22094330-9	2012	To identify which lysines are critical for FoxO3 activity we have generated different FoxO3 mutants that either mimic or prevent lysine acetylation.	Lysine	18-25	forkhead box O3	Homo sapiens	43-48
22094330-9	2012	To identify which lysines are critical for FoxO3 activity we have generated different FoxO3 mutants that either mimic or prevent lysine acetylation.	Lysine	18-24	forkhead box O3	Homo sapiens	43-48
22094330-12	2012	Between the different lysines, lysine 262 is critical for translocation of FoxO3.	Lysine	22-29	forkhead box O3	Homo sapiens	75-80
22094330-12	2012	Between the different lysines, lysine 262 is critical for translocation of FoxO3.	Lysine	22-28	forkhead box O3	Homo sapiens	75-80
22191802-2	2012	A synthetic covalent bond between the UV-photoactivated epirubicin-(C(3)-amide) intermediate and the e-amine of lysine residues within the amino acid sequence of anti-HER2/neu monoclonal immunoglobulin was subsequently created by exposure to UV light (354 nm) for 15 minutes.	Lysine	112-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	167-171
21805137-1	2012	Transglutaminase 2 (TG2) is a multifunctional calcium-dependent enzyme which catalyzes the post-translational protein crosslinking with formation of intra- or inter-molecular epsilon(gamma-glutamyl)lysine bonds or polyamine incorporation.	Lysine	198-204	transglutaminase 2	Homo sapiens	0-18
21805137-1	2012	Transglutaminase 2 (TG2) is a multifunctional calcium-dependent enzyme which catalyzes the post-translational protein crosslinking with formation of intra- or inter-molecular epsilon(gamma-glutamyl)lysine bonds or polyamine incorporation.	Lysine	198-204	transglutaminase 2	Homo sapiens	20-23
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Lysine	125-128	BCL2 apoptosis regulator	Homo sapiens	83-88
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Lysine	125-128	BCL2 like 1	Homo sapiens	97-103
22222205-3	2012	HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8.	Lysine	184-190	histone deacetylase 1	Homo sapiens	0-5
22585859-6	2012	In the death-inducing signaling complex, the C-terminal zinc finger (Znf) domain of the A20 ubiquitin ligase mediates receptor-interacting protein 1 polyubiquitination through lysine-63-linked polyubiquitin chains, which bind to the caspase-8 protease domain and inhibit caspase-8 dimerization, cleavage, and the initiation of TRAIL-induced apoptosis in glioblastoma-derived cell lines and tumor-initiating cells.	Lysine	176-182	TNF superfamily member 10	Homo sapiens	327-332
22389394-2	2012	NF-kappaB and ubiquitylation initially became linked when it was recognised that lysine (K)48-linked ubiquitin chains are involved in the processing of NF-kappaB precursors and the degradation of inhibitor of kappa B (IkappaB) proteins.	Lysine	81-87	nuclear factor kappa B subunit 1	Homo sapiens	0-9
22112863-7	2012	Furthermore, we also demonstrated that phosphorylation of p53 at Thr18 is required for p53 acetylation at lysine 373/382 and for p21 expression in response to depsipeptide treatment.	Lysine	106-112	tumor protein p53	Homo sapiens	58-61
22112863-7	2012	Furthermore, we also demonstrated that phosphorylation of p53 at Thr18 is required for p53 acetylation at lysine 373/382 and for p21 expression in response to depsipeptide treatment.	Lysine	106-112	tumor protein p53	Homo sapiens	87-90
22117218-6	2012	Furthermore, during male PGC development, H3 lysine-4 trimethylation becomes biallelically enriched at "maternal" ICRs, which are protected against DNA methylation, and whose promoters are active in the male germ cells.	Lysine	45-51	progastricsin (pepsinogen C)	Mus musculus	25-28
22170213-2	2012	It has been widely accepted that Lys-48 (K48)-linked polyubiquitination plays a critical role in NF-kappaB signalling by targeting inhibitor of NF-kappaB (IkappaB), thereby leading to its degradation by the proteasome.	Lysine	33-36	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22170213-2	2012	It has been widely accepted that Lys-48 (K48)-linked polyubiquitination plays a critical role in NF-kappaB signalling by targeting inhibitor of NF-kappaB (IkappaB), thereby leading to its degradation by the proteasome.	Lysine	33-36	nuclear factor kappa B subunit 1	Homo sapiens	144-153
22389394-2	2012	NF-kappaB and ubiquitylation initially became linked when it was recognised that lysine (K)48-linked ubiquitin chains are involved in the processing of NF-kappaB precursors and the degradation of inhibitor of kappa B (IkappaB) proteins.	Lysine	81-87	nuclear factor kappa B subunit 1	Homo sapiens	152-161
22053081-7	2012	Chromatin immunoprecipitation (ChIP) analysis revealed that Ago1 was selectively associated with the Ccnb1 promoter and miR-744 increased enrichment of RNA polymerase II (RNAP II) and trimethylation of histone 3 at lysine 4 (H3K4me3) at the Ccnb1 transcription start site.	Lysine	215-221	microRNA 744	Mus musculus	120-127
22113972-5	2012	Ubiquitination experiments using biotinylated ubiquitin showed that the WSTF PHD_EL5 RING finger is poly-ubiquitinated via residue Lys(63) of ubiquitin.	Lysine	131-134	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	72-76
22196887-2	2012	A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine 27 of histone H3 (H3K27me2/3).	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
20641774-0	2004	(111)In-Diethylenetriaminepentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 Glucagon-like peptide-1 (GLP-1, 30 amino acids) is secreted from enteroendocrine cells of the distal small intestine in response to food ingestion (1).	Lysine	62-65	glucagon	Homo sapiens	80-103
20641774-0	2004	(111)In-Diethylenetriaminepentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 Glucagon-like peptide-1 (GLP-1, 30 amino acids) is secreted from enteroendocrine cells of the distal small intestine in response to food ingestion (1).	Lysine	62-65	glucagon	Homo sapiens	105-110
22209848-6	2012	Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues, which serve as ubiquitin acceptors, accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.	Lysine	65-71	WRN helicase interacting protein 1	Homo sapiens	8-14
22209848-6	2012	Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues, which serve as ubiquitin acceptors, accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.	Lysine	65-71	WRN helicase interacting protein 1	Homo sapiens	200-206
22209848-6	2012	Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues, which serve as ubiquitin acceptors, accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.	Lysine	65-71	WRN helicase interacting protein 1	Homo sapiens	200-206
22196887-2	2012	A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine 27 of histone H3 (H3K27me2/3).	Lysine	146-152	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	25-52
22286100-3	2012	Lys 11-linked ubiquitin chains have been implicated in degradation of APC/C substrates, but the Lys 11-chain-forming E2 UBE2S is not essential for mitotic exit, raising questions about the nature of the ubiquitin signal that targets APC/C substrates for degradation.	Lysine	96-99	ubiquitin conjugating enzyme E2 S	Homo sapiens	120-125
22286100-5	2012	When the number of ubiquitylatable lysines in cyclin B1 is restricted, Lys 11-linked ubiquitin polymers elaborated by UBE2S become increasingly important.	Lysine	35-42	ubiquitin conjugating enzyme E2 S	Homo sapiens	118-123
22215600-6	2012	In addition to mediating histone H3 lysine-9 di-methylation (H3K9me2) on MyoD target promoters, endogenous G9a interacts with MyoD in precursor cells and directly methylates it at lysine 104 (K104) to constrain its transcriptional activity.	Lysine	36-42	myogenic differentiation 1	Homo sapiens	73-77
22180156-0	2012	Convergent chemical synthesis of [lysine(24,38,83)] human erythropoietin.	Lysine	34-40	erythropoietin	Homo sapiens	58-72
22200570-5	2012	By coupling several techniques, we demonstrated that the homocysteinylation of lysine residues increase the neurotoxicity of the Abeta peptide by stabilizing soluble oligomeric intermediates.	Lysine	79-85	amyloid beta precursor protein	Homo sapiens	129-134
22148500-2	2012	MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all derivatives was lysine 97.	Lysine	137-143	lysozyme	Homo sapiens	87-95
22044919-2	2012	Given that SIRT1 inhibits the transactivation potential of NF-kappaB by deacetylating acetylated lysines in p65, the NF-kappaB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes.	Lysine	97-104	nuclear factor kappa B subunit 1	Homo sapiens	59-68
22214662-3	2012	Here, we report that RAX/PACT interacts with the SUMO E2 ligase Ubc9 to stimulate p53-Ubc9 association and reversible p53 sumoylation on lysine 386.	Lysine	137-143	tumor protein p53	Homo sapiens	118-121
22156497-6	2012	Notably, we discovered that an unusual RKR motif (Arg(39)-Lys(40)-Arg(41)), conserved only in GzmH, helps define the S3" and S4" binding regions, indicating the preference for acidic residues at the P3" and P4" sites.	Lysine	58-61	granzyme H	Homo sapiens	94-98
22178397-6	2012	Upon heat shock, HSF triggers these PARP activities mechanistically by directing Tip60 acetylation of histone H2A lysine 5 at the 5" end of Hsp70, where inactive PARP resides before heat shock.	Lysine	114-120	Tat interactive protein 60kDa	Drosophila melanogaster	81-86
22020126-0	2012	MYST protein acetyltransferase activity requires active site lysine autoacetylation.	Lysine	61-67	acetyltransferase	Saccharomyces cerevisiae S288C	13-30
22244335-1	2012	Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both the histone methyltransferase COMPASS complex and the cleavage and polyadenylation factor(CPF).	Lysine	167-173	WD repeat domain 82 pseudogene 1	Homo sapiens	207-211
22244335-1	2012	Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both the histone methyltransferase COMPASS complex and the cleavage and polyadenylation factor(CPF).	Lysine	167-173	nuclear receptor subfamily 5 group A member 2	Homo sapiens	323-326
22102414-3	2012	We carefully examined the DNA substrate specificity of purified recombinant human ChlR1 protein and the biochemical effect of a patient-derived mutation, a deletion of a single lysine (K897del) in the extreme C terminus of ChlR1.	Lysine	177-183	DEAD/H-box helicase 11	Homo sapiens	223-228
22020126-2	2012	Here, we demonstrate that MYST protein acetyltransferase activity requires active site lysine autoacetylation.	Lysine	87-93	acetyltransferase	Saccharomyces cerevisiae S288C	39-56
22225877-4	2012	Acetylation of GP Lys(470) enhances its interaction with the PP1 substrate-targeting subunit, G(L), and PP1, thereby promoting GP dephosphorylation and inactivation.	Lysine	18-21	inorganic pyrophosphatase 1	Homo sapiens	61-64
22020126-5	2012	Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro.	Lysine	128-134	histone acetyltransferase	Saccharomyces cerevisiae S288C	192-197
22225877-4	2012	Acetylation of GP Lys(470) enhances its interaction with the PP1 substrate-targeting subunit, G(L), and PP1, thereby promoting GP dephosphorylation and inactivation.	Lysine	18-21	inorganic pyrophosphatase 1	Homo sapiens	104-107
22020126-5	2012	Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro.	Lysine	128-134	histone acetyltransferase	Saccharomyces cerevisiae S288C	199-203
22194015-1	2012	During the last decade, we saw an explosion of studies investigating the role of lysine methylation/demethylation of histones and non-histone proteins, such as p53, NF-kappaB, and E2F1.	Lysine	81-87	tumor protein p53	Homo sapiens	160-163
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	44-47	transforming growth factor beta 1	Homo sapiens	3-10
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	80-83	transforming growth factor beta 1	Homo sapiens	3-10
22069318-6	2012	Polyubiquitination of TAK1 also occurred at Lys-34 in cells stimulated by TNF-alpha and LPS, which activates TLR4, as well as in HepG2 and prostate cancer cells stimulated with TGFbeta, which in all cases resulted in NF-kappaB activation.	Lysine	44-47	tumor necrosis factor	Homo sapiens	74-83
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	15-21	zinc finger and BTB domain containing 17	Homo sapiens	80-84
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	15-21	tumor necrosis factor	Homo sapiens	124-133
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	15-21	mitogen-activated protein kinase 8	Homo sapiens	142-146
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	30-36	zinc finger and BTB domain containing 17	Homo sapiens	80-84
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	30-36	tumor necrosis factor	Homo sapiens	124-133
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Lysine	30-36	mitogen-activated protein kinase 8	Homo sapiens	142-146
22994729-1	2012	The enhancer of zeste homolog 2 (EZH2) methyl transferase and histone 3 lysine 27 (H3K27me3) protein can repress gene transcription, and their aberrant expression has been observed in various human cancers.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
21811504-2	2012	Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	88-92
22186018-5	2012	Using chromatin immunoprecipitation assay, we demonstrate that Pygo2 directly occupies the promoters of multiple histone genes and enhances the acetylation of lysine 56 in histone H3 (H3K56Ac), previously shown to facilitate yeast histone gene transcription at these promoters.	Lysine	159-165	pygopus family PHD finger 2	Homo sapiens	63-68
23275693-5	2012	The involvement of residues like LYS-591, ARG-609, SER-611, GLU-612, SER-613, SER-636 and VAL-637 seems to play an important role in binding of curcumin natural derivatives and its amino acids conjugates with Src Homology (SH2) domain of Stat3 monomer.	Lysine	33-36	signal transducer and activator of transcription 3	Homo sapiens	238-243
22562205-1	2012	The regulated removal of the gene-silencing epigenetic mark, trimethylation of lysine 27 of histone H3 (H3K27me3), has been shown to be critical for tissue-specific activation of developmental genes; however, the extent of embryonic expression of its demethylases, JMJD3 and UTX, has remained unclear.	Lysine	79-85	lysine demethylase 6A S homeolog	Xenopus laevis	275-278
23075766-11	2012	CONCLUSION: The present study provides the direct evidence that SIRT1 can inhibit TNF-alpha- induced CD40 expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-kB at lysine 310, which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1.	Lysine	197-203	tumor necrosis factor	Homo sapiens	82-91
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Lysine	287-293	l(2)46Co	Drosophila melanogaster	374-381
22291472-5	2012	Insulin detemir is a neutral, soluble, long-acting insulin analog in which threonine-30 of the insulin B-chain is deleted, and the C-terminal lysine is acetylated with myristic acid, a C14 fatty acid chain.	Lysine	142-148	insulin	Homo sapiens	0-7
22100383-3	2012	In the N-terminal lobe, the anion-binding residue Arg was substituted with Lys, which represents a common feature in fish and implies a selective preference in the transferrin evolutionary process.	Lysine	75-78	transferrin	Homo sapiens	164-175
22489133-9	2012	Furthermore, methylation potential of human FoxO3 at arginine and lysine residues and crosstalk between methylation and phosphorylation have also been described.	Lysine	66-72	forkhead box O3	Homo sapiens	44-49
23125524-6	2012	Plg-R(KT) exposes a C-terminal lysine on the cell surface in an orientation to bind plasminogen and promote plasminogen activation.	Lysine	31-37	plasminogen receptor with a C-terminal lysine	Homo sapiens	0-9
22949852-5	2012	Histone H3 was found to be trimethylated at lysine 27 by BPA effect on EZH2 in a human breast cancer cell line and mice.	Lysine	44-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	71-75
21964354-3	2012	Although over 20 lysine (K)-acetyl-transferases (KATs) have been characterized, which KAT is responsible for a given protein or lysine site acetylation is mostly unknown.	Lysine	17-23	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	49-52
21964354-4	2012	In this work, we collected KAT-specific acetylation sites manually and analyzed sequence features surrounding the acetylated lysine of substrates from three main KAT families (CBP/p300, GCN5/PCAF, and the MYST family).	Lysine	125-131	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	162-165
21964354-4	2012	In this work, we collected KAT-specific acetylation sites manually and analyzed sequence features surrounding the acetylated lysine of substrates from three main KAT families (CBP/p300, GCN5/PCAF, and the MYST family).	Lysine	125-131	CREB binding protein	Homo sapiens	176-184
21964354-5	2012	We found that each of the three KAT families acetylates lysines with different sequence features.	Lysine	56-63	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	32-35
21964354-6	2012	Based on these differences, we developed a computer program, Acetylation Set Enrichment Based method to predict which KAT-families are responsible for acetylation of a given protein or lysine site.	Lysine	185-191	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	118-121
22389628-4	2012	In response to retinoic acid, CBP/p300 acetylates p53 at lysine 373, which leads to dissociation from E3-ubiquitin ligases HDM2 and TRIM24.	Lysine	57-63	tumor protein p53	Homo sapiens	50-53
22990868-2	2012	Here we identify dimethylation of HSP70 at Lys-561 by SETD1A.	Lysine	43-46	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	54-60
21908408-1	2012	The MYST HAT Sas2 is part of the SAS-I complex that acetylates histone H4 lysine 16 (H4 K16Ac) and blocks the propagation of heterochromatin at the telomeres of Saccharomyces cerevisiae.	Lysine	74-80	histone acetyltransferase	Saccharomyces cerevisiae S288C	13-17
22567014-8	2012	Histone demethylases such as JMJD2B and histone methyltransferases are enzymes which demethylate lysine residues on histones H3 and/or H4.	Lysine	97-103	lysine demethylase 4B	Homo sapiens	29-35
22457632-3	2012	In Arabidopsis, Polycomb Repressor Complex 2 (PRC2), made of PcG proteins, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and PRC1-like proteins catalyze H2AK119 ubiquitination.	Lysine	103-109	cellulose synthase 6	Arabidopsis thaliana	142-146
23166515-1	2012	Heterochromatin protein 1 (HP1) proteins, recognized readers of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me), are important regulators of heterochromatin-mediated gene silencing and chromosome structure.	Lysine	115-121	Suppressor of variegation 205	Drosophila melanogaster	0-25
23166515-1	2012	Heterochromatin protein 1 (HP1) proteins, recognized readers of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me), are important regulators of heterochromatin-mediated gene silencing and chromosome structure.	Lysine	115-121	Suppressor of variegation 205	Drosophila melanogaster	27-30
23285160-0	2012	Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.	Lysine	71-77	arachidonate 15-lipoxygenase	Homo sapiens	30-45
23285160-4	2012	In the present study, we compared the histone 3 lysine 4 (H3-K4) methylation status of the 15-LOX-1 promoter region of the two Hodgkin lymphoma (HL) cell lines L1236 and L428 with abundant and undetectable 15-LOX-1 expression, respectively.	Lysine	48-54	arachidonate 15-lipoxygenase	Homo sapiens	91-99
23056207-2	2012	In prostate cancer, aggressive cases over-express Tip60 which functions as an androgen receptor co-activator via direct acetylation of lysine residues within the KLKK motif of the receptor hinge region.	Lysine	135-141	androgen receptor	Homo sapiens	78-95
23209566-0	2012	Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.	Lysine	21-27	transformation related protein 53 binding protein 1	Mus musculus	46-51
23209566-1	2012	Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires gammaH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me).	Lysine	193-199	transformation related protein 53 binding protein 1	Mus musculus	15-20
23209566-1	2012	Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires gammaH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me).	Lysine	193-199	H2A.X variant histone	Mus musculus	80-89
23209566-1	2012	Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires gammaH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me).	Lysine	193-199	mediator of DNA damage checkpoint 1	Mus musculus	90-94
23209566-1	2012	Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires gammaH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me).	Lysine	193-199	ring finger protein 8	Mus musculus	95-99
23185522-4	2012	To overcome this limitation, we have modified recombinant human TIMP-1 (rhTIMP-1) by PEGylation on lysine residues.	Lysine	99-105	TIMP metallopeptidase inhibitor 1	Homo sapiens	64-70
23155442-4	2012	One sensitizer identified as a conserved determinant of therapeutic success of HDACi was UTX (KDM6A), which demonstrates a functional relationship between protein acetylation and lysine-specific methylation.	Lysine	179-185	lysine demethylase 6A	Homo sapiens	89-92
23155442-4	2012	One sensitizer identified as a conserved determinant of therapeutic success of HDACi was UTX (KDM6A), which demonstrates a functional relationship between protein acetylation and lysine-specific methylation.	Lysine	179-185	lysine demethylase 6A	Homo sapiens	94-99
23077658-1	2012	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that epigenetically silences gene transcription through histone H3 lysine trimethylation (H3K27me3).	Lysine	171-177	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
23077658-1	2012	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that epigenetically silences gene transcription through histone H3 lysine trimethylation (H3K27me3).	Lysine	171-177	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Lysine	15-22	cyclin-dependent kinase 4	Mus musculus	85-89
23024815-0	2012	The histone H4 lysine 20 monomethyl mark, set by PR-Set7 and stabilized by L(3)mbt, is necessary for proper interphase chromatin organization.	Lysine	15-21	lethal (3) malignant brain tumor	Drosophila melanogaster	75-82
22973438-0	2012	Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network.	Lysine	52-58	peroxisome proliferator activated receptor alpha	Mus musculus	89-137
22860050-7	2012	We identified p65 lysines (K) 122 and 123 as target residues mediating the CCTeta-driven termination of NF-kappaB-dependent transcription.	Lysine	18-25	nuclear factor kappa B subunit 1	Homo sapiens	104-113
22905217-4	2012	Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression.	Lysine	26-33	histone deacetylase 1	Homo sapiens	208-213
22720038-3	2012	This Usp46 mutation has a 3-bp deletion coding for lysine in the open reading frame, and we indicated that Usp46 is implicated in the regulation of the GABAergic system.	Lysine	51-57	ubiquitin specific peptidase 46	Mus musculus	5-10
22693575-9	2012	Finally, mutation of these critical lysines in full length E-cadherin had similar effects on protein stability as WT-JMD.	Lysine	36-43	cadherin 1	Homo sapiens	59-69
22792278-2	2012	Dihydrodipicolinate synthase (DHDPS) and dihydrodipicolinate reductase (DHDPR) catalyse the first two committed steps of lysine biosynthesis.	Lysine	121-127	dihydrodipicolinate synthase 1	Arabidopsis thaliana	0-28
22715377-9	2012	Cells expressing p65(S547A) have a higher level of histone H3 acetylated on Lys(9) at the IL8 promoter, which is in agreement with the higher gene induction observed.	Lysine	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	90-93
22720038-3	2012	This Usp46 mutation has a 3-bp deletion coding for lysine in the open reading frame, and we indicated that Usp46 is implicated in the regulation of the GABAergic system.	Lysine	51-57	ubiquitin specific peptidase 46	Mus musculus	107-112
22666422-2	2012	MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K4me3).	Lysine	122-128	multiple endocrine neoplasia 1	Mus musculus	0-4
22666422-2	2012	MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K4me3).	Lysine	122-128	multiple endocrine neoplasia 1	Mus musculus	13-18
22666422-2	2012	MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K4me3).	Lysine	122-128	lysine (K)-specific methyltransferase 2A	Mus musculus	33-37
22666422-2	2012	MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K4me3).	Lysine	122-128	lysine (K)-specific methyltransferase 2B	Mus musculus	38-42
22563434-4	2012	Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2).	Lysine	36-42	interferon gamma	Homo sapiens	66-75
21911017-1	2011	We report an efficient strategy to conjugate methacrylamide moieties to the lysine units of lysozyme for co-polymerization and subsequent triggered release from hydrogels.	Lysine	76-82	lysozyme	Homo sapiens	92-100
22563434-4	2012	Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2).	Lysine	36-42	interferon gamma	Homo sapiens	157-173
22563434-4	2012	Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2).	Lysine	36-42	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	324-328
22247766-5	2012	These lysine mutations did not affect the level of expression of Foxp3 but inhibited IL-2 promoter remodeling and had important and differing effects on Treg-associated gene expression.	Lysine	6-12	interleukin 2	Homo sapiens	85-89
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	168-174	multiple endocrine neoplasia 1	Mus musculus	67-72
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	272-278	multiple endocrine neoplasia 1	Mus musculus	67-72
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	272-278	multiple endocrine neoplasia 1	Mus musculus	67-72
22072716-3	2011	Representative enzymes from this group, Ubp15 from yeast and its human ortholog USP7, rapidly remove mono- and diubiquitin from substrates but are slow to remove longer Lys(48)-linked chains.	Lysine	169-172	ubiquitin-specific protease UBP15	Saccharomyces cerevisiae S288C	40-45
22106309-4	2011	However, our results show that GLS1 differs from PFKFB3 in that its recognition by APC/C-Cdh1 requires the presence of both a Lys-Glu-Asn box (KEN box) and a destruction box (D box) rather than a KEN box alone.	Lysine	126-129	cadherin 1	Homo sapiens	89-93
21965678-5	2011	SUMO conjugation on Lys-509, which is located within the SUMO consensus site, together with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, probably by recruiting HDAC2 onto the PS2 promoter.	Lysine	20-23	taste 2 receptor member 64 pseudogene	Homo sapiens	159-162
21965678-5	2011	SUMO conjugation on Lys-509, which is located within the SUMO consensus site, together with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, probably by recruiting HDAC2 onto the PS2 promoter.	Lysine	20-23	histone deacetylase 2	Homo sapiens	201-206
21965678-5	2011	SUMO conjugation on Lys-509, which is located within the SUMO consensus site, together with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, probably by recruiting HDAC2 onto the PS2 promoter.	Lysine	20-23	taste 2 receptor member 64 pseudogene	Homo sapiens	216-219
22016387-5	2011	Arp2/3-5 (actin-related protein 2/3 subunit 5) and coronin 1A were polyubiquitinated by GRAIL via Lys-48 and Lys-63 linkages.	Lysine	98-101	coronin 1A	Homo sapiens	51-61
22133676-2	2011	Jumonji domain containing 2B (JMJD2B) is a newly identified histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3.	Lysine	181-187	lysine demethylase 4B	Homo sapiens	0-28
22133676-2	2011	Jumonji domain containing 2B (JMJD2B) is a newly identified histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3.	Lysine	181-187	lysine demethylase 4B	Homo sapiens	30-36
22016387-5	2011	Arp2/3-5 (actin-related protein 2/3 subunit 5) and coronin 1A were polyubiquitinated by GRAIL via Lys-48 and Lys-63 linkages.	Lysine	109-112	coronin 1A	Homo sapiens	51-61
22021076-4	2011	One of these ubiquitination events depends on lysines 13 and 20 and forces rapid Pex18p turnover by proteasomal degradation.	Lysine	46-53	Pex18p	Saccharomyces cerevisiae S288C	81-87
22100894-2	2011	In this study, we show that p300 acetylates Notch1 ICD in cell culture assay and in vitro, and conserved lysines located within the Notch C-terminal nuclear localization signal are essential for Notch acetylation.	Lysine	105-112	notch receptor 1	Homo sapiens	132-137
22030396-6	2011	Uncoupling FKBP38 from Hsp90 by substituting a conserved lysine in the TPR domain modestly enhances CFTR maturation and further reduces its synthesis.	Lysine	57-63	CF transmembrane conductance regulator	Homo sapiens	100-104
22002246-3	2011	Here we report that DOT1L, the non-SET domain containing methyltransferase that modifies Lys-79, is localized across IRF1 in the uninduced state and is not further recruited by IFN-gamma induction.	Lysine	89-92	DOT1 like histone lysine methyltransferase	Homo sapiens	20-25
22123949-4	2011	SUV39H1 is the principal enzyme responsible for trimethylation of histone H3 at lysine 9, a molecular mark associated with transcriptional silencing.	Lysine	80-86	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
22123949-7	2011	Degradation of SUV39H1 by Siah facilitates histone H3 on lysine 9 acetylation, CREB binding to DNA, enhanced expression of CREB-regulated genes and neurite outgrowth.	Lysine	57-63	SUV39H1 histone lysine methyltransferase	Homo sapiens	15-22
21787808-5	2011	Based on peptide 1 and the analogue cyclo(3-5)[Sar(1), Asp(3), Lys(5)]-AII characterized by Matsoukas et al., we analyzed the agonistic and antagonistic activities, respectively, through a new monocyclic peptide series synthesized by using the following combinations of residues as bridgehead elements for the lactam bond formation: D- or L-Asp combined with D- or L-Lys or L-Glu combined with L-Orn.	Lysine	63-66	angiotensinogen	Homo sapiens	71-74
22020933-5	2011	NHE1-phosphoinositide binding was enhanced by acidic pH, and abolished by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic interactions.	Lysine	83-86	solute carrier family 9 member A1	Homo sapiens	0-4
22020933-5	2011	NHE1-phosphoinositide binding was enhanced by acidic pH, and abolished by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic interactions.	Lysine	83-86	solute carrier family 9 member A1	Homo sapiens	74-78
22079090-4	2011	Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TRbeta1 within the E2F1 gene promoter.	Lysine	36-42	histamine N-methyltransferase L homeolog	Xenopus laevis	71-74
21834846-5	2011	Interestingly, UTX-1 belongs to a conserved family of histone demethylases specific for lysine 27 of histone H3 (H3K27me3), a mark associated with repressed chromatin.	Lysine	88-94	JmjC domain-containing protein	Caenorhabditis elegans	15-20
21985982-4	2011	Examination of a panel of individual or clustered lysine mutants demonstrated that lysine 613 (K613) in the cytoplasmic tail of Dll1 is a key residue necessary for transcellular activation of Notch signaling.	Lysine	83-89	notch receptor 1	Homo sapiens	192-197
21679053-5	2011	CA XIII formed more adducts (up to 25) than it contains lysine residues (n = 16) in its primary structure.	Lysine	56-62	carbonic anhydrase 13	Homo sapiens	0-7
22199132-2	2011	We synthesized novel internally quenched fluorogenic (IQF) substrates for ACE based on the cleavage site of an angiotensin I, introducing N-methyl anthranic acid (Nma) and N(epsilon)-2,4-dinitrophenyl-lysine (Lys(Dnp))at the N- and C-terminal regions.	Lysine	209-212	angiotensin I converting enzyme	Homo sapiens	74-77
22199132-2	2011	We synthesized novel internally quenched fluorogenic (IQF) substrates for ACE based on the cleavage site of an angiotensin I, introducing N-methyl anthranic acid (Nma) and N(epsilon)-2,4-dinitrophenyl-lysine (Lys(Dnp))at the N- and C-terminal regions.	Lysine	209-212	angiotensinogen	Homo sapiens	111-124
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Lysine	38-41	angiotensin I converting enzyme	Homo sapiens	227-230
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Lysine	64-67	angiotensin I converting enzyme	Homo sapiens	227-230
22199132-8	2011	The newly developed IQF substrate, Nma-Phe-His-Lys(Dnp), is a valuable tool for ACE and carboxypeptidase studies.	Lysine	47-50	angiotensin I converting enzyme	Homo sapiens	80-83
21925125-7	2011	RESULTS: We found that CD44 binds directly to HER2, which up-regulates the expression of metastasis-associated protein-1, induces deacetylation of histone H3 lysine 9, and suppresses transcription of microRNA139 (miR-139) to inhibit expression of its target gene, C-X-C chemokine receptor type 4 (CXCR4).	Lysine	158-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-50
21890497-1	2011	MTU1 (TRMU) is a mitochondrial enzyme responsible for the 2-thiolation of the wobble U in tRNA(Lys), tRNA(Glu) and tRNA(Gln), a post-transcriptional modification believed to be important for accurate and efficient synthesis of the 13 respiratory chain subunits encoded by mtDNA.	Lysine	95-98	tRNA mitochondrial 2-thiouridylase	Homo sapiens	0-4
21890497-1	2011	MTU1 (TRMU) is a mitochondrial enzyme responsible for the 2-thiolation of the wobble U in tRNA(Lys), tRNA(Glu) and tRNA(Gln), a post-transcriptional modification believed to be important for accurate and efficient synthesis of the 13 respiratory chain subunits encoded by mtDNA.	Lysine	95-98	tRNA mitochondrial 2-thiouridylase	Homo sapiens	6-10
21597459-5	2011	Hades polyubiquitinates p53 in vitro independent of Mdm2 and targets a critical lysine residue in p53 (lysine 24) distinct from those targeted by Mdm2.	Lysine	80-86	tumor protein p53	Homo sapiens	24-27
21597459-5	2011	Hades polyubiquitinates p53 in vitro independent of Mdm2 and targets a critical lysine residue in p53 (lysine 24) distinct from those targeted by Mdm2.	Lysine	80-86	tumor protein p53	Homo sapiens	98-101
21597459-5	2011	Hades polyubiquitinates p53 in vitro independent of Mdm2 and targets a critical lysine residue in p53 (lysine 24) distinct from those targeted by Mdm2.	Lysine	103-109	tumor protein p53	Homo sapiens	24-27
21597459-5	2011	Hades polyubiquitinates p53 in vitro independent of Mdm2 and targets a critical lysine residue in p53 (lysine 24) distinct from those targeted by Mdm2.	Lysine	103-109	tumor protein p53	Homo sapiens	98-101
22384690-0	2011	Transformation of LRP gene into Brassica napus mediated by Agrobacterium tumefaciens to enhance lysine content in seeds.	Lysine	96-102	40S ribosomal protein SA	Brassica napus	18-21
21321941-5	2011	Mechanistically, we observed more HDAC1 recruitment and a weaker association of histone 4 lysine 5 acetylation at the Fgf4 enhancer in P19 cells compared to F9 cells.	Lysine	90-96	fibroblast growth factor 4	Mus musculus	118-122
21858699-1	2011	The possible hydrolysis of substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met) in presence of the osteoblastic cell line SaOS-2 was measured by capillary electrophoresis coupled to mass detection.	Lysine	48-51	tachykinin precursor 1	Homo sapiens	27-38
21934067-3	2011	Proteolysis of CRP yields the C-terminal peptide Lys(201)-Pro-Gln-Leu-Trp-Pro(206).	Lysine	49-52	C-reactive protein	Homo sapiens	15-18
21934067-8	2011	Substitution of Lys(201), Gln(203), or Trp(205) with Ala in CRP peptide 201-206 resulted in loss of the biological activities, whereas peptides in which Pro(202), Leu(204), or Pro(206) was substituted with Ala retained biological activity.	Lysine	16-19	C-reactive protein	Homo sapiens	60-63
21899893-6	2011	METHODS: Human lung epithelial NCI-H292 cells were stimulated with a TLR2 agonist Palmitoyl (3)-Cys-Ser-Lys (4)-OH (Pam(3)CSK(4)).	Lysine	104-107	toll like receptor 2	Homo sapiens	69-73
22036612-7	2011	In contrast, a positive correlation between AIRE expression and histone H3 lysine 4 trimethylation, an active chromatin mark, was found in the AIRE promoter in human and mouse TECs.	Lysine	75-81	autoimmune regulator	Homo sapiens	44-48
22036612-7	2011	In contrast, a positive correlation between AIRE expression and histone H3 lysine 4 trimethylation, an active chromatin mark, was found in the AIRE promoter in human and mouse TECs.	Lysine	75-81	autoimmune regulator	Homo sapiens	143-147
22312702-5	2011	The PEG-ylated L-asparaginase consisted of different isomers from mono to multi PEG-ylated depending upon the number of Lysine residues (14 in case of L-asparaginase) with about 5% as native protein.	Lysine	120-126	asparaginase and isoaspartyl peptidase 1	Homo sapiens	15-29
22207391-2	2011	Our system contains a lysine-based (micro-, e-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea motif exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety.	Lysine	22-28	folate hydrolase 1	Homo sapiens	85-89
22207391-2	2011	Our system contains a lysine-based (micro-, e-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea motif exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety.	Lysine	98-101	folate hydrolase 1	Homo sapiens	85-89
22131404-4	2011	Our studies reveal that SIRT1 also offers protection against polyQ-expanded AR by deacetylating the AR at lysines 630/632/633.	Lysine	106-113	androgen receptor	Homo sapiens	76-78
22242002-2	2011	In Neurospora crassa, heterochromatin formation requires methylation of histone H3 at lysine 9 (H3K9) by the SET domain protein DIM-5.	Lysine	86-92	H3 clustered histone 14	Homo sapiens	80-82
22131404-4	2011	Our studies reveal that SIRT1 also offers protection against polyQ-expanded AR by deacetylating the AR at lysines 630/632/633.	Lysine	106-113	androgen receptor	Homo sapiens	100-102
22131404-7	2011	Moreover, genetic mutation to inhibit polyQ-expanded AR acetylation of lysines 630/632/633 substantially decreased its aggregation and completely abrogated its toxicity in cell lines and motor neurons.	Lysine	71-78	androgen receptor	Homo sapiens	53-55
22010849-3	2011	Unexpectedly, the conjugation method did not affect the binding efficacy of scFv, suggesting a structural role of lysines in the scFv molecule.	Lysine	114-121	immunglobulin heavy chain variable region	Homo sapiens	129-133
21868378-0	2011	Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid beta peptide length: support for a sequential model of gamma-secretase intramembrane proteolysis and regulation by the amyloid beta precursor protein (APP) juxtamembrane region.	Lysine	0-6	amyloid beta precursor protein	Homo sapiens	206-236
21868378-5	2011	We have identified an amino acid in the juxtamembrane region of APP, lysine 624, on the basis of APP695 numbering (position 28 relative to Abeta) that plays a critical role in determining the final length of Abeta peptides released by gamma-secretase.	Lysine	69-75	amyloid beta precursor protein	Homo sapiens	139-144
21868378-5	2011	We have identified an amino acid in the juxtamembrane region of APP, lysine 624, on the basis of APP695 numbering (position 28 relative to Abeta) that plays a critical role in determining the final length of Abeta peptides released by gamma-secretase.	Lysine	69-75	amyloid beta precursor protein	Homo sapiens	208-213
21921037-1	2011	Setdb1/Eset is a histone H3 lysine 9 (H3K9)-specific methyltransferase that associates with various transcription factors to regulate gene expression via chromatin remodeling.	Lysine	28-34	SET domain, bifurcated 1	Mus musculus	0-6
21921037-1	2011	Setdb1/Eset is a histone H3 lysine 9 (H3K9)-specific methyltransferase that associates with various transcription factors to regulate gene expression via chromatin remodeling.	Lysine	28-34	SET domain, bifurcated 1	Mus musculus	7-11
21965659-7	2011	Importantly, we identified a cluster of three membrane-proximal betac lysine residues (Lys(457), Lys(461), and Lys(467)) whose presence was required for both JAK1/2 binding to betac and receptor ubiquitination.	Lysine	70-76	Janus kinase 1	Homo sapiens	158-162
21965659-7	2011	Importantly, we identified a cluster of three membrane-proximal betac lysine residues (Lys(457), Lys(461), and Lys(467)) whose presence was required for both JAK1/2 binding to betac and receptor ubiquitination.	Lysine	87-90	Janus kinase 1	Homo sapiens	158-162
21965659-7	2011	Importantly, we identified a cluster of three membrane-proximal betac lysine residues (Lys(457), Lys(461), and Lys(467)) whose presence was required for both JAK1/2 binding to betac and receptor ubiquitination.	Lysine	97-100	Janus kinase 1	Homo sapiens	158-162
21965659-7	2011	Importantly, we identified a cluster of three membrane-proximal betac lysine residues (Lys(457), Lys(461), and Lys(467)) whose presence was required for both JAK1/2 binding to betac and receptor ubiquitination.	Lysine	97-100	Janus kinase 1	Homo sapiens	158-162
21940822-3	2011	Recently, we identified a novel transmembrane plasminogen receptor, Plg-R(KT), which exposes a C-terminal lysine on the cell surface.	Lysine	106-112	plasminogen receptor, C-terminal lysine transmembrane protein	Mus musculus	68-77
22099308-0	2011	NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.	Lysine	42-48	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
22099308-3	2011	Here, we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2.	Lysine	50-56	nuclear receptor binding SET domain protein 2	Homo sapiens	121-125
21926431-4	2011	Here, we have identified and characterized lysine-based sorting signals that determine the restricted localization of DHHC4 and DHHC6 to ER membranes.	Lysine	43-49	zinc finger DHHC-type palmitoyltransferase 4	Homo sapiens	118-123
22086334-2	2011	Here we show that G9a or G9a-like protein (GLP) dimethylate the amino-terminal lysine 44 (K44) of mouse Dnmt3a (equivalent to K47 of human DNMT3A) in vitro and in cells overexpressing G9a or GLP.	Lysine	79-85	DNA methyltransferase 3A	Mus musculus	104-110
21926431-4	2011	Here, we have identified and characterized lysine-based sorting signals that determine the restricted localization of DHHC4 and DHHC6 to ER membranes.	Lysine	43-49	zinc finger DHHC-type palmitoyltransferase 6	Homo sapiens	128-133
21908427-6	2011	The ANXA2 subunit of AIIt functions to stabilize and anchor S100A10 to the plasma membrane, whereas the S100A10 subunit initiates the fibrinolytic cascade by colocalizing with the urokinase type plasminogen activator and receptor complex and also providing a common binding site for both tissue-type plasminogen activator and plasminogen via its C-terminal lysine residue.	Lysine	357-363	S100 calcium binding protein A10	Homo sapiens	104-111
22102238-1	2011	Dihydrodipicolinate synthase (DHDPS; EC 4.2.1.52) catalyzes the first committed step of the lysine-biosynthetic pathway in plants and bacteria.	Lysine	92-98	dihydrodipicolinate synthase 1	Arabidopsis thaliana	0-28
21880715-2	2011	Here we report that SMYD2 prefers to methylate p53 Lys-370 over histone substrates in vitro.	Lysine	51-54	tumor protein p53	Homo sapiens	47-50
21880715-3	2011	Consistently, the level of endogenous p53 Lys-370 monomethylation is significantly elevated when SMYD2 is overexpressed in vivo.	Lysine	42-45	tumor protein p53	Homo sapiens	38-41
21917920-0	2011	HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia.	Lysine	42-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-33
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Lysine	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Lysine	28-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-178
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Lysine	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Lysine	45-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-178
21880715-10	2011	Meanwhile, mutation of EDEE residues impairs both the binding and the enzymatic activity of SMYD2 to p53 Lys-370.	Lysine	105-108	tumor protein p53	Homo sapiens	101-104
21880715-11	2011	These data together reveal the molecular basis of SMYD2 in specifically recognizing and regulating functions of p53 tumor suppressor through Lys-370 monomethylation.	Lysine	141-144	tumor protein p53	Homo sapiens	112-115
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	mitogen-activated protein kinase 8	Homo sapiens	186-189
22053792-3	2011	Miz-1 differentiation-associated target genes specifically lack acetylated lysine 9 and trimethylated lysine 4 of histone H3 (AcH3K9 and H3K4me3) 9 histone marks, consistent with a repressed transcriptional state.	Lysine	75-81	zinc finger and BTB domain containing 17	Homo sapiens	0-5
22053792-3	2011	Miz-1 differentiation-associated target genes specifically lack acetylated lysine 9 and trimethylated lysine 4 of histone H3 (AcH3K9 and H3K4me3) 9 histone marks, consistent with a repressed transcriptional state.	Lysine	102-108	zinc finger and BTB domain containing 17	Homo sapiens	0-5
22102238-1	2011	Dihydrodipicolinate synthase (DHDPS; EC 4.2.1.52) catalyzes the first committed step of the lysine-biosynthetic pathway in plants and bacteria.	Lysine	92-98	dihydrodipicolinate synthase 1	Arabidopsis thaliana	30-35
22102238-2	2011	Since (S)-lysine biosynthesis does not occur in animals, DHDPS is an attractive target for rational antibiotic and herbicide design.	Lysine	6-16	dihydrodipicolinate synthase 1	Arabidopsis thaliana	57-62
22080598-2	2011	In vegetative organs, LEC2 expression is negatively regulated by Polycomb Repressive Complex2 (PRC2) that catalyzes histone H3 Lys 27 trimethylation (H3K27me3) and plays a crucial role in developmental phase transitions.	Lysine	127-130	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	22-26
21873498-1	2011	Histone methylation, a determinant of chromatin structure and gene transcription, was thought to be irreversible, but recent evidence suggests that lysine-specific demethylase-1 (LSD1, Kdm1a) induces demethylation of histone H3 lysine 4 (H3K4) or H3K9 and thereby alters gene transcription.	Lysine	148-154	lysine (K)-specific demethylase 1A	Mus musculus	179-183
21873498-1	2011	Histone methylation, a determinant of chromatin structure and gene transcription, was thought to be irreversible, but recent evidence suggests that lysine-specific demethylase-1 (LSD1, Kdm1a) induces demethylation of histone H3 lysine 4 (H3K4) or H3K9 and thereby alters gene transcription.	Lysine	148-154	lysine (K)-specific demethylase 1A	Mus musculus	185-190
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 3	Mus musculus	74-82
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 3	Mus musculus	100-104
22033337-4	2011	Our results show that virus infection induces p53 acetylation at lysine 379, and that this modification is absolutely required for p53-dependent transcriptional transactivation of both, pro-apoptotic and IFN-stimulated genes induced by virus infection, and for p53-mediated control of virus replication.	Lysine	65-71	tumor protein p53	Homo sapiens	46-49
22033337-4	2011	Our results show that virus infection induces p53 acetylation at lysine 379, and that this modification is absolutely required for p53-dependent transcriptional transactivation of both, pro-apoptotic and IFN-stimulated genes induced by virus infection, and for p53-mediated control of virus replication.	Lysine	65-71	tumor protein p53	Homo sapiens	131-134
22033337-4	2011	Our results show that virus infection induces p53 acetylation at lysine 379, and that this modification is absolutely required for p53-dependent transcriptional transactivation of both, pro-apoptotic and IFN-stimulated genes induced by virus infection, and for p53-mediated control of virus replication.	Lysine	65-71	interferon alpha 1	Homo sapiens	204-207
22033337-4	2011	Our results show that virus infection induces p53 acetylation at lysine 379, and that this modification is absolutely required for p53-dependent transcriptional transactivation of both, pro-apoptotic and IFN-stimulated genes induced by virus infection, and for p53-mediated control of virus replication.	Lysine	65-71	tumor protein p53	Homo sapiens	131-134
21302286-9	2011	In addition, it was trans-stimulated (~7.8-fold) by L-lysine in absence of insulin, but unaltered (~1.4-fold) in presence of insulin.	Lysine	52-60	insulin	Homo sapiens	75-82
21302286-11	2011	Insulin increased NO synthesis and caused endothelium-dependent vessel relaxation and reduced U46619-induced contraction, effects blocked by NEM and L-lysine, and dependent on extracellular L-arginine.	Lysine	149-157	insulin	Homo sapiens	0-7
21903722-2	2011	We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog 2 (EZH2), resulting in declining levels of trimethylation of histone 3 on lysine 27 (H3K27me3) at the proximal promoters of key decidual marker genes PRL and IGFBP1.	Lysine	176-182	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	105-109
22045334-7	2011	We have mapped Smurf2-induced Smad3 ubiquitination sites to lysine residues at the MH2 domain, and demonstrate that Smad3 ubiquitination inhibits the formation of Smad3 complexes.	Lysine	60-66	SMAD specific E3 ubiquitin protein ligase 2	Mus musculus	15-21
22002947-0	2011	Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.	Lysine	32-35	lysine demethylase 6A	Homo sapiens	56-59
22002947-0	2011	Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.	Lysine	32-35	lysine demethylase 6A	Homo sapiens	60-65
21884823-0	2011	Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice.	Lysine	30-36	negative elongation factor complex member C/D, Th1l	Mus musculus	83-86
21884823-0	2011	Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice.	Lysine	30-36	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	107-116
21708268-0	2011	Preparation of monomeric B27 Lys destripeptide insulin by intein mediated expression in Escherichia coli.	Lysine	29-32	melanocortin 2 receptor accessory protein	Homo sapiens	25-28
21708268-0	2011	Preparation of monomeric B27 Lys destripeptide insulin by intein mediated expression in Escherichia coli.	Lysine	29-32	insulin	Homo sapiens	47-54
21708268-1	2011	The B27K-DTrI insulin (human insulin with B28-30 removed and B27 Thr replaced by Lys) was reported to have superior monomeric property with 80% insulin activity in vivo.	Lysine	81-84	insulin	Homo sapiens	14-21
21708268-1	2011	The B27K-DTrI insulin (human insulin with B28-30 removed and B27 Thr replaced by Lys) was reported to have superior monomeric property with 80% insulin activity in vivo.	Lysine	81-84	insulin	Homo sapiens	29-36
21708268-1	2011	The B27K-DTrI insulin (human insulin with B28-30 removed and B27 Thr replaced by Lys) was reported to have superior monomeric property with 80% insulin activity in vivo.	Lysine	81-84	melanocortin 2 receptor accessory protein	Homo sapiens	4-7
21708268-1	2011	The B27K-DTrI insulin (human insulin with B28-30 removed and B27 Thr replaced by Lys) was reported to have superior monomeric property with 80% insulin activity in vivo.	Lysine	81-84	insulin	Homo sapiens	29-36
21922608-5	2011	Recruitment of Nurr1, a transcription factor crucial for midbrain DA neuron development, to the promoter of TH gene was enhanced by depolarization, along with increases of histone 3 acetylation (H3Ac) and trimethylation of histone3 on lysine 4 (H3K4m3), and decreases of H3K9m3 and H3K27m3 in the consensus Nurr1 binding regions of TH promoter.	Lysine	235-241	tyrosine hydroxylase	Homo sapiens	108-110
21916458-6	2011	Mass spectrometry and solution-state NMR demonstrated binding of CLR01 to the Lys residues in Abeta at the earliest stages of assembly.	Lysine	78-81	amyloid beta precursor protein	Homo sapiens	94-99
21878652-9	2011	Ecm29 was enriched on proteasomes of pocket lysine mutants, as well as those of rpt4-Delta1 and rpt6-Delta1 mutants, in which the C-terminal residue, thought to contact the pocket lysine, is deleted.	Lysine	44-50	Ecm29 proteasome adaptor and scaffold	Homo sapiens	0-5
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Lysine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	108-121
21936573-2	2011	Crude MRPs derived from Glu-Lys showed the greatest capacity (P &lt; 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells.	Lysine	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
21878652-9	2011	Ecm29 was enriched on proteasomes of pocket lysine mutants, as well as those of rpt4-Delta1 and rpt6-Delta1 mutants, in which the C-terminal residue, thought to contact the pocket lysine, is deleted.	Lysine	180-186	Ecm29 proteasome adaptor and scaffold	Homo sapiens	0-5
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	TNFAIP3 interacting protein 1	Homo sapiens	0-5
21979373-2	2011	Chd1 binds to nucleosomes trimethylated at histone 3 Lys 4 (H3K4me3) near the beginning of active genes but not to bivalent domains also containing H3K27me3.	Lysine	53-56	chromodomain helicase DNA binding protein 1	Mus musculus	0-4
21501700-7	2011	Tandem mass spectrometry and investigations of mutated forms of apoA-I demonstrate that tyrosine residues in apoA-I are chlorinated in a site-specific manner by chloramine intermediates on suitably juxtaposed lysine residues.	Lysine	209-215	apolipoprotein A1	Homo sapiens	109-115
21532618-5	2011	EZH2 represses rap1GAP by facilitating the trimethylation of histone 3 at lysine 27, a mark of gene repression, and also hypermethylation of rap1GAP promoter.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21983563-3	2011	RNA polymerase II large subunit (Pol II) and bromodomain protein 4 (BRD4) were recruited to the locus in a different sequential order on interphase initiation versus post-mitotic re-activation resulting from the recognition by BRD4 of increased levels of histone H4 Lys 5 acetylation (H4K5ac) on the previously activated locus.	Lysine	266-269	bromodomain containing 4	Homo sapiens	45-66
21899370-1	2011	The endocannabinoid hydrolyzing enzyme FAAH uses a nonclassical catalytic triad (namely, Ser-Ser-Lys instead of Ser-Asp-His) to cleave its endogenous substrates.	Lysine	97-100	fatty acid amide hydrolase	Homo sapiens	39-43
21862595-0	2011	Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-beta-Smad pathway.	Lysine	10-16	interleukin 2	Homo sapiens	63-76
21862595-0	2011	Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-beta-Smad pathway.	Lysine	10-16	interleukin 2	Homo sapiens	78-82
21862595-0	2011	Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-beta-Smad pathway.	Lysine	10-16	interleukin 2	Homo sapiens	126-130
21983563-3	2011	RNA polymerase II large subunit (Pol II) and bromodomain protein 4 (BRD4) were recruited to the locus in a different sequential order on interphase initiation versus post-mitotic re-activation resulting from the recognition by BRD4 of increased levels of histone H4 Lys 5 acetylation (H4K5ac) on the previously activated locus.	Lysine	266-269	bromodomain containing 4	Homo sapiens	68-72
21983563-3	2011	RNA polymerase II large subunit (Pol II) and bromodomain protein 4 (BRD4) were recruited to the locus in a different sequential order on interphase initiation versus post-mitotic re-activation resulting from the recognition by BRD4 of increased levels of histone H4 Lys 5 acetylation (H4K5ac) on the previously activated locus.	Lysine	266-269	bromodomain containing 4	Homo sapiens	227-231
21856302-0	2011	The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states.	Lysine	71-77	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
21856302-2	2011	These mutations were shown to change the substrate specificity of EZH2 for various methylation states of lysine 27 on histone H3 (H3K27).	Lysine	105-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	66-70
21791603-4	2011	Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.	Lysine	114-120	tumor protein p53	Homo sapiens	50-53
21740311-6	2011	It was also demonstrated that oxidized fibrinogen is bound to apolipoprotein(a) of lipoprotein(a) via lysine binding sites.	Lysine	102-108	fibrinogen beta chain	Homo sapiens	39-49
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21777709-7	2011	Chromatin immunoprecipitation assay demonstrated an increased association of both RNA polymerase II (Pol II) and ATF4 at the Atf3 promoter in LP offspring, while acetylated histone H4, tri-methyl histone H3 at lysine 9, ATF4, ATF3, C/EBPbeta, and CHOP, but not Pol II, were all increased at the Asns promoter in LP offspring.	Lysine	210-216	activating transcription factor 4	Rattus norvegicus	113-117
23071946-7	2011	Amino acids like alanine, glycine, lysine, serine and 4-hydroxy proline showed strong stabilizing effect on catalase during lyophilization by protecting catalase activity above 95%, whereas valine and cysteine hydrochloride showed destabilizing effect on catalase.	Lysine	35-41	catalase	Homo sapiens	108-116
23071946-7	2011	Amino acids like alanine, glycine, lysine, serine and 4-hydroxy proline showed strong stabilizing effect on catalase during lyophilization by protecting catalase activity above 95%, whereas valine and cysteine hydrochloride showed destabilizing effect on catalase.	Lysine	35-41	catalase	Homo sapiens	153-161
23071946-7	2011	Amino acids like alanine, glycine, lysine, serine and 4-hydroxy proline showed strong stabilizing effect on catalase during lyophilization by protecting catalase activity above 95%, whereas valine and cysteine hydrochloride showed destabilizing effect on catalase.	Lysine	35-41	catalase	Homo sapiens	153-161
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	tumor protein p53	Homo sapiens	50-53
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	50-53
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	97-100
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	tumor protein p53	Homo sapiens	50-53
21871446-6	2011	Furthermore, supplementation of endothelial cells with extracellular L-arginine enhanced insulin-stimulated NO synthesis, an effect reversed by co-incubation with the L-arginine transport inhibitor, L-lysine.	Lysine	199-207	insulin	Homo sapiens	89-96
22028615-7	2011	WHSC1 interacts with some proteins related to the WNT pathway including beta-catenin and transcriptionally regulates CCND1, the target gene of the beta-catenin/Tcf-4 complex, through histone H3 at lysine 36 trimethylation.	Lysine	197-203	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
21795702-6	2011	Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro.	Lysine	62-65	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	14-18
21795702-6	2011	Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro.	Lysine	62-65	dynactin subunit 6	Homo sapiens	98-101
21757724-7	2011	Using chromatin immunoprecipitation, we demonstrated that IRF-1 binds to the 5" TG promoter motif, and the transcription factor binding correlates with active chromatin structure and is marked by enrichment of mono-methylated Lys-4 residue of histone H3, a signature of active transcriptional enhancers.	Lysine	226-229	interferon regulatory factor 1	Homo sapiens	58-63
21868449-6	2011	We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140.	Lysine	142-148	cyclin dependent kinase 8	Homo sapiens	75-80
21868449-7	2011	We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter.	Lysine	47-53	cyclin dependent kinase 8	Homo sapiens	155-159
21868449-7	2011	We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter.	Lysine	47-53	cyclin dependent kinase 8	Homo sapiens	172-176
21823679-8	2011	Comparison of the results obtained using alpha-lactalbumin and the dipeptide made clear that the Maillard reaction rate is determined by a number of factors, including saccharide reactivity and lysine accessibility.	Lysine	194-200	lactalbumin alpha	Homo sapiens	41-58
21760613-3	2011	We used an integrated approach to investigate the dynamics of the conserved methylation of histone H3 Lys 79 (H3K79) by Dot1.	Lysine	102-105	DOT1 like histone lysine methyltransferase	Homo sapiens	120-124
21780790-1	2011	Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53.	Lysine	8-14	tumor protein p53	Homo sapiens	251-254
21728379-1	2011	The elucidation of extra-nuclear lysine acetylation has been of growing interest, as the cosubstrate for acetylation, acetyl CoA, is at a key metabolic intersection.	Lysine	33-39	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1	Mus musculus	125-128
21737840-9	2011	The facilitation of GGR is achieved through enabling monoubiquitination of histone H2B lysine 123 by Bre1, which in turn permits di- and trimethylation of histone H3 lysine 79 by Dot1.	Lysine	87-93	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	179-183
21737840-9	2011	The facilitation of GGR is achieved through enabling monoubiquitination of histone H2B lysine 123 by Bre1, which in turn permits di- and trimethylation of histone H3 lysine 79 by Dot1.	Lysine	166-172	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	179-183
22977606-2	2011	Enhancer of zeste homolog 2 (EZH2) is the target of miR-101 and a member of the polycomb repressive complex 2, which is involved in the methylation of histone H3 at lysine 27 (H3K27).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
22977606-2	2011	Enhancer of zeste homolog 2 (EZH2) is the target of miR-101 and a member of the polycomb repressive complex 2, which is involved in the methylation of histone H3 at lysine 27 (H3K27).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
21642393-7	2011	Comparative modeling with OATP1A2 and OATP2B1 revealed that the pore size around this lysine residue is larger in OATP1A2 and smaller in OATP2B1 compared with OATP1B3, which could be related to the respective substrate spectra.	Lysine	86-92	solute carrier organic anion transporter family member 1B3	Homo sapiens	159-166
21708170-2	2011	In vitro experiments have shown that the proline-glutamic acid-valine-lysine (PEVK) rich element of titin interacts with actin, causing a viscous force in the sarcomere.	Lysine	70-76	titin	Mus musculus	100-105
21642393-0	2011	Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3.	Lysine	68-74	solute carrier organic anion transporter family member 1B3	Homo sapiens	87-129
21654327-2	2011	In cultured endothelial cells, 2 atherogenic stimuli, hydrogen peroxide and tumor necrosis factor-alpha, increased the acetylation of p53 lysine-382, and caspase-3 cleavage, an indicator of apoptotic signaling.	Lysine	138-144	tumor necrosis factor	Mus musculus	76-103
21715480-4	2011	Knockdown of EZH2, a key component of the Polycomb repressive complex 2 (PRC2) silencing machinery, and the enzyme which is required for trimethyl histone lysine 27 (H3K27me3) synthesis induced up to 40% of the latent HIV proviruses.	Lysine	155-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	13-17
21642393-8	2011	Cell surface expression of L399&gt;A and L399&gt;R was decreased to 16 and 72% compared with wild-type OATP1B3 (p &lt; 0.001), respectively, indicating that the positive charge of lysine at position 399 is necessary for an unimpaired cell surface expression.	Lysine	180-186	solute carrier organic anion transporter family member 1B3	Homo sapiens	103-110
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	mitogen-activated protein kinase 1	Homo sapiens	174-211
21820311-5	2011	Here, we show that deposition of histone 3 lysine 9 by the methyltransferase dSETDB1 (egg) is required for piRNA cluster transcription.	Lysine	43-49	eggless	Drosophila melanogaster	77-84
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	mitogen-activated protein kinase 1	Homo sapiens	213-216
21832969-4	2011	These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT&gt;GAG; Asp&gt;Glu) and 420 (ACG&gt;AAG; Thr&gt;Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.	Lysine	144-147	D-box binding PAR bZIP transcription factor	Homo sapiens	67-70
21832969-6	2011	RESULTS: On statistical analysis, we observed that the DBP 420 variant Lys is less frequent in IBD cases than in non-IBD controls (allele frequencies, P=0.034; homozygous carrier genotype frequencies, P=0.006).	Lysine	71-74	D-box binding PAR bZIP transcription factor	Homo sapiens	55-58
21832969-8	2011	Although the DBP position 416 alone was not found to be significantly associated with IBD, the haplotype DBP_2, consisting of 416 Asp and 420 Lys, was more frequent in the non-IBD population, particularly notably when compared with the UC group (Odds ratio, 4.390).	Lysine	142-145	D-box binding PAR bZIP transcription factor	Homo sapiens	105-108
21665952-8	2011	Replacing Lys(159)/Lys(190) residues of ChREBP with alanine resulted in loss of importin-alpha binding, glucose-stimulated transcriptional activity and nuclear localization.	Lysine	10-13	MLX interacting protein-like	Rattus norvegicus	40-46
21855805-2	2011	In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines.	Lysine	70-76	tumor protein p53	Homo sapiens	63-66
21855805-2	2011	In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines.	Lysine	70-76	tumor protein p53	Homo sapiens	82-85
21855806-3	2011	Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash et al., 2008).	Lysine	82-88	tumor protein p53	Homo sapiens	42-45
21855806-3	2011	Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash et al., 2008).	Lysine	82-88	tumor protein p53	Homo sapiens	78-81
21841797-1	2011	The lysyl-tRNA synthetase paralog PoxA modifies elongation factor P (EF-P) with alpha-lysine at low efficiency.	Lysine	80-92	lysyl-tRNA synthetase 1	Homo sapiens	4-25
21665952-8	2011	Replacing Lys(159)/Lys(190) residues of ChREBP with alanine resulted in loss of importin-alpha binding, glucose-stimulated transcriptional activity and nuclear localization.	Lysine	19-22	MLX interacting protein-like	Rattus norvegicus	40-46
21788519-6	2011	Repression of NRT2.1 transcription by high N supply is associated with an HNI9/AtIWS1-dependent increase in histone H3 lysine 27 trimethylation at the NRT2.1 locus.	Lysine	119-125	nitrate transporter 2:1	Arabidopsis thaliana	14-18
21788519-6	2011	Repression of NRT2.1 transcription by high N supply is associated with an HNI9/AtIWS1-dependent increase in histone H3 lysine 27 trimethylation at the NRT2.1 locus.	Lysine	119-125	nitrate transporter 2:1	Arabidopsis thaliana	14-20
21794016-8	2011	These results indicate that low lysine concentrations in culture medium inhibit differentiation of 3T3-L1 preadipocytes through inhibiting the mRNA expressions of PPARgamma and C/EBPalpha.	Lysine	32-38	CCAAT enhancer binding protein alpha	Sus scrofa	177-187
21763278-16	2011	In HEK 293 cells, furin cleaved pro-BNP at Arg-76 whereas in cardiomyocytes corin cleaved pro-BNP at multiple residues including Arg-73, Arg-76 and Lys-79.	Lysine	148-151	corin, serine peptidase	Homo sapiens	76-81
21794016-6	2011	mRNA expressions of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) were lower in cells cultured in low lysine medium.	Lysine	171-177	CCAAT enhancer binding protein alpha	Sus scrofa	85-121
21425435-6	2011	We further hypothesized that IUGR would, in a gender-specific manner, alter the levels of MeCP2 components in association with changes in PPARgamma mRNA, MeCP2 occupancy at the PPARgamma promoters, and PPARgamma histone 3 lysine 9 trimethylation (H3K9Me3).	Lysine	222-228	methyl CpG binding protein 2	Rattus norvegicus	90-95
21794016-6	2011	mRNA expressions of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) were lower in cells cultured in low lysine medium.	Lysine	171-177	CCAAT enhancer binding protein alpha	Sus scrofa	123-133
21606950-3	2011	Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase Dnmt3a by binding to its plant homeodomain (PHD).	Lysine	44-50	DNA methyltransferase 3A	Mus musculus	128-134
21656660-7	2011	Activation of nongenomic ER signaling via the phosphotidylinositol-3-kinase (PI3K) pathway activates the kinase AKT/PKB in the developing reproductive tract, which phosphorylates the histone lysine methyltransferase (HKMT) EZH2, the key "installer" of epigenetic histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	191-197	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	223-227
21734572-7	2011	SUMMARY: Glycation of LDL occurs chiefly because of the nonenzymatic reaction of glucose and its metabolites with the free amino groups of lysine of which apolipoprotein B is rich.	Lysine	139-145	apolipoprotein B	Homo sapiens	155-171
21599834-7	2011	We optimized a P1 Lys-containing substrate to enhance sensitivity towards CG and prevent cleavage by chymase and beta2-tryptase.	Lysine	18-21	chymase 1	Homo sapiens	101-108
21642861-8	2011	Interestingly, p53 acetylation at lysine 382 was significantly increased, and c-myc expression simultaneously down-regulated in cotreated cells.	Lysine	34-40	tumor protein p53	Homo sapiens	15-18
21746811-3	2011	In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (Smu) bearing H3K9me3 (trimethylated histone H3 at lysine 9) in vivo.	Lysine	236-242	tripartite motif containing 28	Homo sapiens	65-69
21746811-3	2011	In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (Smu) bearing H3K9me3 (trimethylated histone H3 at lysine 9) in vivo.	Lysine	236-242	tripartite motif containing 28	Homo sapiens	71-103
21642861-10	2011	Furthermore, c-myc down-regulation and apoptotic cell death coinduced by IR and HDACI were suppressed in cells transfected with mutant K382R p53 and C135Y p53 displaying loss of acetylation at lysine 382 and DNA-binding activity, respectively.	Lysine	193-199	tumor protein p53	Homo sapiens	141-144
21642861-10	2011	Furthermore, c-myc down-regulation and apoptotic cell death coinduced by IR and HDACI were suppressed in cells transfected with mutant K382R p53 and C135Y p53 displaying loss of acetylation at lysine 382 and DNA-binding activity, respectively.	Lysine	193-199	tumor protein p53	Homo sapiens	155-158
21515635-7	2011	Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues.	Lysine	248-254	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	154-159
21808242-2	2011	The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).	Lysine	255-258	signal transducer and activator of transcription 3	Homo sapiens	120-125
21633971-6	2011	Furthermore, the basic Lys and Arg are enriched within SNARE N-terminal flanking regions.	Lysine	23-26	small NF90 (ILF3) associated RNA E	Homo sapiens	55-60
21679093-5	2011	A highly positively charged substrate, Ac-Val-Arg-Leu-Lys-His-Arg-Lys-Leu-Arg-pNA, containing the peptide surrounding the phosphorylated histidine in ion channel KCa3.1 was chemically phosphorylated using phosphoramidate.	Lysine	54-57	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	162-168
21632534-7	2011	We find that inhibition of the chain trimming activity of the 26 S proteasome with Ub aldehyde significantly inhibits degradation of Ub4 (Lys-48)-UbcH10 and causes accumulation of free Ub4 (generated from chain amputation) that can be retained on the proteasome.	Lysine	138-141	ubiquitin conjugating enzyme E2 C	Homo sapiens	146-152
21746928-0	2011	Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.	Lysine	11-17	zinc metallopeptidase, STE24	Mus musculus	105-113
21632534-8	2011	Also, a non-trimmable Lys-48-mimic Ub4 efficiently targets UbcH10 to the 26 S proteasome, but it cannot support efficient degradation of UbcH10 compared with regular Lys-48 Ub4.	Lysine	22-25	ubiquitin conjugating enzyme E2 C	Homo sapiens	59-65
21775285-3	2011	We show that Akt and PDK1 are acetylated at lysine residues in their pleckstrin homology domains, which mediate PIP(3) binding.	Lysine	44-50	thymoma viral proto-oncogene 1	Mus musculus	13-16
21774827-2	2011	Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of histone 3 (H3K9me3), but the mechanism of H3K9me3-dependent repression remains unknown.	Lysine	104-110	SET domain, bifurcated 1	Mus musculus	73-79
21645662-6	2011	Drug-LZM products had been prepared by first coupling BOC-l-methionine hydroxysuccinimide ester (BOCmet) to lysine residues of LZM followed by conjugation with the kinase inhibitors LY364947, erlotinib, or Y27632 via a platinum(II)-based linker.	Lysine	108-114	lysozyme	Homo sapiens	5-8
21645662-6	2011	Drug-LZM products had been prepared by first coupling BOC-l-methionine hydroxysuccinimide ester (BOCmet) to lysine residues of LZM followed by conjugation with the kinase inhibitors LY364947, erlotinib, or Y27632 via a platinum(II)-based linker.	Lysine	108-114	lysozyme	Homo sapiens	127-130
21775285-3	2011	We show that Akt and PDK1 are acetylated at lysine residues in their pleckstrin homology domains, which mediate PIP(3) binding.	Lysine	44-50	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	21-25
21708125-3	2011	Among the point-mutations, an acetylation site at lysine 458 was found significant in the HNF4alpha-mediated transcriptional control.	Lysine	50-56	hepatocyte nuclear factor 4 alpha	Homo sapiens	90-99
21684259-1	2011	In budding yeast, there are five JmjC domain-containing proteins, Jhd1, Jhd2, Rph1, Ecm5, and Gis1, which have been suggested to directly remove histone lysine methylation via a hydroxylation reaction.	Lysine	153-159	histone demethylase	Saccharomyces cerevisiae S288C	72-76
21586571-0	2011	Peptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction.	Lysine	57-64	tumor protein p53	Homo sapiens	80-83
21586571-0	2011	Peptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction.	Lysine	57-64	tumor protein p53	Homo sapiens	124-127
21586571-7	2011	Acetylation of lysine 382/381 enhanced the binding of this peptide to PC4 by about an order of magnitude.	Lysine	15-21	SUB1 regulator of transcription	Homo sapiens	70-73
21586571-9	2011	Intermolecular nuclear Overhauser effect placed aspartate 76 in the vicinity of lysine 381, indicating that the region around residues 73-76 of PC4 is important for p53 recognition.	Lysine	80-86	SUB1 regulator of transcription	Homo sapiens	144-147
21586571-9	2011	Intermolecular nuclear Overhauser effect placed aspartate 76 in the vicinity of lysine 381, indicating that the region around residues 73-76 of PC4 is important for p53 recognition.	Lysine	80-86	tumor protein p53	Homo sapiens	165-168
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	tumor protein p53	Homo sapiens	39-42
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	SUB1 regulator of transcription	Homo sapiens	94-97
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	tumor protein p53	Homo sapiens	136-139
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	tumor protein p53	Homo sapiens	136-139
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	SUB1 regulator of transcription	Homo sapiens	185-188
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	SUB1 regulator of transcription	Homo sapiens	185-188
21586571-10	2011	We conclude that the 380-386 region of p53 interacts with the region around residues 73-76 of PC4, and acetylation of lysine 382/381 of p53 may play an important role in modulating p53-PC4 interaction and as a consequence PC4 mediated activation of p53 target genes.	Lysine	118-124	tumor protein p53	Homo sapiens	136-139
21741597-1	2011	The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene.	Lysine	14-20	DOT1 like histone lysine methyltransferase	Homo sapiens	50-55
21726816-2	2011	MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail.	Lysine	108-114	male-specific lethal 1	Drosophila melanogaster	20-24
21733196-6	2011	CGGBP1 depletion also increased the expression of cell cycle regulatory genes CDKN1A and GAS1, associated with reductions in histone H3 lysine 9 trimethylation in their promoters.	Lysine	136-142	CGG triplet repeat binding protein 1	Homo sapiens	0-6
21684259-1	2011	In budding yeast, there are five JmjC domain-containing proteins, Jhd1, Jhd2, Rph1, Ecm5, and Gis1, which have been suggested to directly remove histone lysine methylation via a hydroxylation reaction.	Lysine	153-159	histone demethylase GIS1	Saccharomyces cerevisiae S288C	94-98
21605328-0	2011	Epigenetic, polymorphic and mutational (Alphaalpha167Arg Lys) contribution to a functionally abnormal fibrinogen.	Lysine	57-60	fibrinogen beta chain	Homo sapiens	102-112
21600186-3	2011	To examine the contribution of each active site to the enzymatic activity of ALAS/ALAS, the catalytic lysine, which also covalently binds the PLP cofactor, was substituted with alanine in one of the active sites.	Lysine	102-108	5'-aminolevulinate synthase 1	Homo sapiens	77-81
21600186-3	2011	To examine the contribution of each active site to the enzymatic activity of ALAS/ALAS, the catalytic lysine, which also covalently binds the PLP cofactor, was substituted with alanine in one of the active sites.	Lysine	102-108	5'-aminolevulinate synthase 1	Homo sapiens	82-86
21565980-3	2011	SIRT1, the main member of the sirtuin family, inactivates p53 by deacetylating a critical lysine residue.	Lysine	90-96	tumor protein p53	Homo sapiens	58-61
21724828-2	2011	Since the discovery ~10 years ago that Dot1 and its mammalian homolog, DOT1L (DOT1-Like), possess histone methyltransferase activity toward histone H3 Lys 79, great progress has been made in characterizing their enzymatic activities and the role of Dot1/DOT1L-mediated H3K79 methylation in transcriptional regulation, cell cycle regulation, and the DNA damage response.	Lysine	151-154	DOT1 like histone lysine methyltransferase	Homo sapiens	39-43
21724828-2	2011	Since the discovery ~10 years ago that Dot1 and its mammalian homolog, DOT1L (DOT1-Like), possess histone methyltransferase activity toward histone H3 Lys 79, great progress has been made in characterizing their enzymatic activities and the role of Dot1/DOT1L-mediated H3K79 methylation in transcriptional regulation, cell cycle regulation, and the DNA damage response.	Lysine	151-154	DOT1 like histone lysine methyltransferase	Homo sapiens	71-76
21724828-2	2011	Since the discovery ~10 years ago that Dot1 and its mammalian homolog, DOT1L (DOT1-Like), possess histone methyltransferase activity toward histone H3 Lys 79, great progress has been made in characterizing their enzymatic activities and the role of Dot1/DOT1L-mediated H3K79 methylation in transcriptional regulation, cell cycle regulation, and the DNA damage response.	Lysine	151-154	DOT1 like histone lysine methyltransferase	Homo sapiens	78-87
21504520-8	2011	In MTD, Ppargamma is epigenetically repressed by induction of methyl-CpG binding protein 2 and its enrichment to the promoter and polycomb repressive complex-facilitated histone H3 lysine 27 di/tri-methylation at the 3" exons.	Lysine	181-187	peroxisome proliferator activated receptor gamma	Homo sapiens	8-17
21529950-6	2011	Based on distance geometry method and intermolecular interaction theory, the key residue Lys(68) in C5a identified by F20 was predicted.	Lysine	89-92	complement C5a receptor 1	Homo sapiens	100-103
21443952-5	2011	These comprehensive analyses have revealed (i) that RAD6 serves as the cognate E2 for the BRE1 complex in human cells, as previously established in yeast, (ii) that RAD6, through direct interaction with the BRE1 complex, ubiquitylates chromatinized H2B at lysine 120 and (iii) that PAF1 complex-mediated transcription is required for efficient H2B ubiquitylation.	Lysine	256-262	ring finger protein 20	Homo sapiens	90-94
21443952-5	2011	These comprehensive analyses have revealed (i) that RAD6 serves as the cognate E2 for the BRE1 complex in human cells, as previously established in yeast, (ii) that RAD6, through direct interaction with the BRE1 complex, ubiquitylates chromatinized H2B at lysine 120 and (iii) that PAF1 complex-mediated transcription is required for efficient H2B ubiquitylation.	Lysine	256-262	Paf1p	Saccharomyces cerevisiae S288C	282-286
21566084-5	2011	Maximal binding of GATA4 precedes ERalpha binding, and GATA4 is necessary for histone 3 lysine 4 dimethylation at ERalpha binding sites, suggesting that GATA4 is a pioneer factor for ERalpha.	Lysine	88-94	estrogen receptor 1	Homo sapiens	114-121
21566084-5	2011	Maximal binding of GATA4 precedes ERalpha binding, and GATA4 is necessary for histone 3 lysine 4 dimethylation at ERalpha binding sites, suggesting that GATA4 is a pioneer factor for ERalpha.	Lysine	88-94	estrogen receptor 1	Homo sapiens	114-121
21555453-4	2011	The transcription factor GATA1 can be acetylated at lysine residues adjacent to the zinc finger domains, and this acetylation is essential for the normal chromatin occupancy of GATA1.	Lysine	52-58	GATA binding protein 1	Homo sapiens	25-30
21529950-7	2011	The mutant experimental results showed that the residue Lys(68) was the critical residue of C5a for it"s bioactivity and F20 binding activity.	Lysine	56-59	complement C5a receptor 1	Homo sapiens	92-95
21555453-4	2011	The transcription factor GATA1 can be acetylated at lysine residues adjacent to the zinc finger domains, and this acetylation is essential for the normal chromatin occupancy of GATA1.	Lysine	52-58	GATA binding protein 1	Homo sapiens	177-182
21508930-2	2011	We show that CBP is critical for the in vivo acetylation of lysines on histones H2B, H3, and H4.	Lysine	60-67	CREB binding protein	Homo sapiens	13-16
21518767-3	2011	In this study, we demonstrate that two lysine residues (Lys-153 and Lys-157) in the C-terminal region of the yeast E2-conjugating enzyme Ubc9 are the major and minor autosumoylation sites, respectively.	Lysine	39-45	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	137-141
21341993-4	2011	Poly-l-lysine-coated VEGF/alginate microspheres were combined with demineralized bone matrices into composites, and the in vitro release of VEGF from these composites was evaluated under periodic compression.	Lysine	0-13	vascular endothelial growth factor A	Homo sapiens	21-25
21341993-4	2011	Poly-l-lysine-coated VEGF/alginate microspheres were combined with demineralized bone matrices into composites, and the in vitro release of VEGF from these composites was evaluated under periodic compression.	Lysine	0-13	vascular endothelial growth factor A	Homo sapiens	140-144
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	141-147	nuclear receptor subfamily 2 group C member 2	Homo sapiens	87-90
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	141-147	nuclear receptor subfamily 2 group C member 2	Homo sapiens	301-304
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	141-147	nuclear receptor subfamily 2 group C member 2	Homo sapiens	301-304
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	156-162	nuclear receptor subfamily 2 group C member 2	Homo sapiens	87-90
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	156-162	nuclear receptor subfamily 2 group C member 2	Homo sapiens	301-304
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	156-162	nuclear receptor subfamily 2 group C member 2	Homo sapiens	301-304
21527774-0	2011	The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.	Lysine	34-40	cytochrome c, somatic	Homo sapiens	52-64
21527774-4	2011	Site-specific BQ-lysine adducts are found on residues in cytochrome c that are necessary for protein-protein interactions, and these adducts contribute to interferences in its ability to facilitate apoptosome formation.	Lysine	17-23	cytochrome c, somatic	Homo sapiens	57-69
21521686-4	2011	The longer mBMAL1 fragment (BMAL490) includes Lys-537, which is rhythmically acetylated by mCLOCK in vivo.	Lysine	46-49	circadian locomotor output cycles kaput	Mus musculus	91-97
21531708-1	2011	WD repeat-containing protein 5 (WDR5) is a common component of mammalian mixed lineage leukemia methyltransferase family members and is important for histone H3 lysine 4 methylation (H3K4me), which has been implicated in control of activation of cell lineage genes during embryogenesis.	Lysine	161-167	WD repeat domain 5	Homo sapiens	0-30
21531708-1	2011	WD repeat-containing protein 5 (WDR5) is a common component of mammalian mixed lineage leukemia methyltransferase family members and is important for histone H3 lysine 4 methylation (H3K4me), which has been implicated in control of activation of cell lineage genes during embryogenesis.	Lysine	161-167	WD repeat domain 5	Homo sapiens	32-36
21518767-3	2011	In this study, we demonstrate that two lysine residues (Lys-153 and Lys-157) in the C-terminal region of the yeast E2-conjugating enzyme Ubc9 are the major and minor autosumoylation sites, respectively.	Lysine	56-59	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	137-141
21518767-3	2011	In this study, we demonstrate that two lysine residues (Lys-153 and Lys-157) in the C-terminal region of the yeast E2-conjugating enzyme Ubc9 are the major and minor autosumoylation sites, respectively.	Lysine	68-71	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	137-141
21518767-4	2011	Surprisingly, mutation of Lys-157 (ubc9(K157R)) significantly stimulates the level of Ubc9 autosumoylation at Lys-153.	Lysine	26-29	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	35-39
21518767-4	2011	Surprisingly, mutation of Lys-157 (ubc9(K157R)) significantly stimulates the level of Ubc9 autosumoylation at Lys-153.	Lysine	26-29	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	86-90
21518767-4	2011	Surprisingly, mutation of Lys-157 (ubc9(K157R)) significantly stimulates the level of Ubc9 autosumoylation at Lys-153.	Lysine	110-113	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	35-39
21518767-4	2011	Surprisingly, mutation of Lys-157 (ubc9(K157R)) significantly stimulates the level of Ubc9 autosumoylation at Lys-153.	Lysine	110-113	E2 SUMO-conjugating protein UBC9	Saccharomyces cerevisiae S288C	86-90
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	18-21	albumin	Homo sapiens	81-88
21680843-4	2011	Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.	Lysine	155-161	poly(ADP-ribose) polymerase 1	Homo sapiens	114-119
21680843-4	2011	Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.	Lysine	155-161	poly(ADP-ribose) polymerase 1	Homo sapiens	146-151
21680843-4	2011	Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.	Lysine	155-161	poly(ADP-ribose) polymerase 1	Homo sapiens	146-151
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21502321-7	2011	Although certain acetylations present a repressive impact on PRMT1-mediated methylation (type I methylation), lysine acetylation generally is correlated with enhanced methylation by PRMT5 (type II dimethylation).	Lysine	110-116	protein arginine methyltransferase 5	Homo sapiens	182-187
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21329771-5	2011	Here we show that Lys-4, Lys-12, Lys-137, Lys-159, Lys-205, and Lys-212 of human albumin are susceptible to N-homocysteinylation in vitro and provide evidence that two of those residues, Lys-137 and Lys-212, in addition to Lys-525, are N-homocysteinylated in vivo in human plasma.	Lysine	25-28	albumin	Homo sapiens	81-88
21460230-3	2011	We have developed a novel IGF-I variant by site-specific addition of polyethylene glycol (PEG) to lysine 68 (PEG-IGF-I).	Lysine	98-104	insulin like growth factor 1	Homo sapiens	26-31
21460230-3	2011	We have developed a novel IGF-I variant by site-specific addition of polyethylene glycol (PEG) to lysine 68 (PEG-IGF-I).	Lysine	98-104	insulin like growth factor 1	Homo sapiens	113-118
21367571-12	2011	This report demonstrates for the first time that (1) GCN5 differentially affects expression of multiple genes, (2) ethanol-induced histone H3-lysine 9 acetylation is mediated via GCN5, and (3) GCN5 is involved in ethanol-induced expression of the putative choline transporter SLC44A2.	Lysine	142-148	solute carrier family 44 member 2	Homo sapiens	276-283
21467042-1	2011	Partial digestion of fibrin by plasmin exposes C-terminal lysine residues, which comprise new binding sites for both plasminogen and tissue-type plasminogen activator (tPA).	Lysine	58-64	plasminogen activator, tissue type	Homo sapiens	133-166
21402181-6	2011	In contrast, microcapsules containing poly-L-lysine (PLL) induced elevated levels of sTCC, Bb, C3a and C5a, surface active C3 convertase and leukocyte adhesion.	Lysine	38-51	complement C5a receptor 1	Homo sapiens	103-106
21293030-0	2011	The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility.	Lysine	84-90	lysine (K)-specific demethylase 4D	Mus musculus	41-46
21493592-2	2011	In muscle myoblast cells, ectopic expression of the histone H3 lysine 9 (H3K9) methytransferase KMT1A blocks differentiation by repressing a myogenic gene expression program.	Lysine	63-69	SUV39H1 histone lysine methyltransferase	Homo sapiens	96-101
21463657-5	2011	Overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity.	Lysine	114-120	tumor protein p53	Homo sapiens	107-110
21512140-1	2011	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
21826189-0	2011	Regulation of p53 function by lysine methylation.	Lysine	30-36	tumor protein p53	Homo sapiens	14-17
21512140-1	2011	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
21540640-4	2011	In this study, we report that transcription of RunX1T1 was confirmed to be positively regulated by SMAD4 in IOSE cells and epigenetically silenced in a panel of ovarian cancer cell lines by promoter hypermethylation and histone methylation at H3 lysine 9.	Lysine	246-252	RUNX1 translocation partner 1	Mus musculus	47-54
20497197-2	2011	[(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation.	Lysine	27-30	prepronociceptin	Homo sapiens	36-41
20497197-2	2011	[(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation.	Lysine	27-30	prepronociceptin	Homo sapiens	64-67
21826189-2	2011	In addition to histones, several other nuclear factors such as the tumor suppressor and transcription factor p53 undergo lysine methylation, suggesting that this modification may be a common mechanism for modulating protein-protein interactions and key cellular signaling pathways.	Lysine	121-127	tumor protein p53	Homo sapiens	109-112
21826189-3	2011	This article focuses on how lysine methylation events on the C-terminal tail of p53 are generated, sensed and transduced to modulate p53 functions.	Lysine	28-34	tumor protein p53	Homo sapiens	80-83
21826189-3	2011	This article focuses on how lysine methylation events on the C-terminal tail of p53 are generated, sensed and transduced to modulate p53 functions.	Lysine	28-34	tumor protein p53	Homo sapiens	133-136
21540074-7	2011	Fbxl10 encodes a demethylase specific to the histone H3 mono/di-methylated at lysine 36 (H3K36me1/me2) and forms complexes with polycomb-group proteins, essential regulators of HSCs.	Lysine	78-84	lysine (K)-specific demethylase 2B	Mus musculus	0-6
21444723-0	2011	Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.	Lysine	27-33	mitogen-activated protein kinase 14	Homo sapiens	71-74
21830492-3	2011	In our group, we have shown that when covalently coupled to Poly-Glutamic Acid (PGA) the incorporation of an anti-inflammatory hormone (melanocortin, a-MSH) into the multilayered films Poly-L-Lysine (PLL)/PGA increases the anti-inflammatory reaction of pulp fibroblasts and macrophages stimulated by LPS (Lipo-Polysaccharides).	Lysine	185-198	proopiomelanocortin	Homo sapiens	152-155
21511880-6	2011	Transient recruitment of the histone acetyl transferase complex cAMP response element-binding protein (CREB) binding protein (CBP)/p300 is found to precisely track the ultradian hormone rhythm, resulting in transient localized net changes in lysine acetylation at GC-regulatory regions after each pulse.	Lysine	242-248	CREB binding protein	Homo sapiens	103-124
21444723-4	2011	We identified two acetylated lysine residues, K152 and K53, located in the substrate binding domain and in the ATP-binding pocket of p38, respectively.	Lysine	29-35	mitogen-activated protein kinase 14	Homo sapiens	133-136
21511880-6	2011	Transient recruitment of the histone acetyl transferase complex cAMP response element-binding protein (CREB) binding protein (CBP)/p300 is found to precisely track the ultradian hormone rhythm, resulting in transient localized net changes in lysine acetylation at GC-regulatory regions after each pulse.	Lysine	242-248	CREB binding protein	Homo sapiens	126-129
21527503-7	2011	In addition, progestin prevented dissociation of the corepressors Yin and Yang 1 and histone deacetylase 3 from the promoter, and demethylation of lysine 9 of histone 3 induced by PRL and glucocorticoids.	Lysine	147-153	prolactin	Homo sapiens	180-183
21444723-5	2011	Acetylation of lysine 53 enhanced the activity of p38 by increasing its affinity for ATP binding.	Lysine	15-21	mitogen-activated protein kinase 14	Homo sapiens	50-53
21444723-7	2011	Thus, our data show, for the first time, that p38 activity is critically regulated by, in addition to phosphorylation, reversible acetylation of a lysine residue, which is conserved in other kinases, implying the possibility of a similar mechanism regulating their activity.	Lysine	147-153	mitogen-activated protein kinase 14	Homo sapiens	46-49
21536911-3	2011	The hematopoietic transcription factor GATA1 is acetylated at conserved lysines that are required for its stable association with chromatin.	Lysine	72-79	GATA binding protein 1	Homo sapiens	39-44
21571640-7	2011	The inhibition by GM3 was released by either removing the neuraminic acid of the GM3 headgroup or by mutating a membrane proximal lysine of EGFR (K642G).	Lysine	130-136	epidermal growth factor receptor	Homo sapiens	140-144
21525412-0	2011	Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration.	Lysine	15-21	tumor protein p53	Homo sapiens	29-32
21596426-2	2011	The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3).	Lysine	101-107	bromodomain PHD finger transcription factor	Homo sapiens	31-35
21460225-0	2011	Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.	Lysine	109-115	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	44-48
21460225-3	2011	Dot1, a histone methyltransferase required for methylation of histone H3 lysine 79 (H3K79), has been shown to confer yeast cells with resistance to DNA-damaging agents and play a role in activation of DNA damage checkpoints.	Lysine	73-79	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
21596310-5	2011	L3MBTL2-specific RNAi resulted in increased expression of target genes that exhibited a significant reduction in H2A lysine 119 monoubiquitination.	Lysine	117-123	L3MBTL histone methyl-lysine binding protein 2	Homo sapiens	0-7
21454694-5	2011	An additional mutation that reduced the affinity of CPM for C-terminal Arg and increased the affinity for C-terminal Lys inhibited the B1R response to bradykinin (with C-terminal Arg) but generated a response to Lys(9)-bradykinin.	Lysine	117-120	bradykinin receptor B1	Homo sapiens	135-138
21454694-5	2011	An additional mutation that reduced the affinity of CPM for C-terminal Arg and increased the affinity for C-terminal Lys inhibited the B1R response to bradykinin (with C-terminal Arg) but generated a response to Lys(9)-bradykinin.	Lysine	117-120	kininogen 1	Homo sapiens	151-161
21525412-3	2011	We prepared p53 specifically acetylated at Lys120, AcK120p53, by in vivo incorporation of acetylated lysine to study biophysical and structural consequences of acetylation that may shed light on its biological role.	Lysine	101-107	tumor protein p53	Homo sapiens	12-15
21482738-3	2011	In this report, we extend the role of ubiquitination at this lysine residue from Nef-mediated CD4 downregulation to Nef-mediated MHC-I downregulation and from HIV Nef to SIV Nef.	Lysine	61-67	S100 calcium binding protein B	Homo sapiens	81-84
21482738-3	2011	In this report, we extend the role of ubiquitination at this lysine residue from Nef-mediated CD4 downregulation to Nef-mediated MHC-I downregulation and from HIV Nef to SIV Nef.	Lysine	61-67	CD4 molecule	Homo sapiens	94-97
21482738-3	2011	In this report, we extend the role of ubiquitination at this lysine residue from Nef-mediated CD4 downregulation to Nef-mediated MHC-I downregulation and from HIV Nef to SIV Nef.	Lysine	61-67	S100 calcium binding protein B	Homo sapiens	116-119
21402695-7	2011	Examination of the sulfate-binding site analysis reveals two key lysine residues, Lys-28 and Lys-85, within the C2 domain that are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca(2+)-independent localization mechanism for Smurf1.	Lysine	65-71	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	145-151
21402695-7	2011	Examination of the sulfate-binding site analysis reveals two key lysine residues, Lys-28 and Lys-85, within the C2 domain that are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca(2+)-independent localization mechanism for Smurf1.	Lysine	65-71	ras homolog family member A	Homo sapiens	253-257
21454479-6	2011	In addition, loss of the histone chaperone Hif1p, when combined with an allele of H3 that mutates lysines 14 and 23 to arginine, has a pronounced effect on chromatin reassembly that is similar to that observed in an asf1Delta.	Lysine	98-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
21402695-7	2011	Examination of the sulfate-binding site analysis reveals two key lysine residues, Lys-28 and Lys-85, within the C2 domain that are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca(2+)-independent localization mechanism for Smurf1.	Lysine	65-71	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	330-336
21402695-7	2011	Examination of the sulfate-binding site analysis reveals two key lysine residues, Lys-28 and Lys-85, within the C2 domain that are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca(2+)-independent localization mechanism for Smurf1.	Lysine	82-85	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	145-151
21402695-7	2011	Examination of the sulfate-binding site analysis reveals two key lysine residues, Lys-28 and Lys-85, within the C2 domain that are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca(2+)-independent localization mechanism for Smurf1.	Lysine	93-96	SMAD specific E3 ubiquitin protein ligase 1	Homo sapiens	145-151
21388951-9	2011	Src transformation significantly decreased the acetylation levels of histone H4 and increased the trimethylation levels of histone H3 lysine 27 in the cbp promoter.	Lysine	134-140	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	14-18
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	cyclin dependent kinase inhibitor 2A	Homo sapiens	109-112
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	cyclin dependent kinase inhibitor 2A	Homo sapiens	113-118
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	cyclin dependent kinase inhibitor 1A	Homo sapiens	124-127
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	cyclin dependent kinase inhibitor 1A	Homo sapiens	128-132
21572997-4	2011	Enrichment of EZH2, the key factor that methylates histone H3 lysine 9 and 27 residues, was decreased on the p16(INK4A) and p21(CIP1/WAF1) promoter regions.	Lysine	62-68	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-137
21502526-4	2011	Nearly all FAAH inhibitors known to date attain their binding potency through a reversible or irreversible covalent modification of the nucleophile Ser241 in the unusual Ser-Ser-Lys catalytic triad.	Lysine	178-181	fatty acid amide hydrolase	Homo sapiens	11-15
21217779-6	2011	The CBP/p300 proteins were recruited to sites of DSBs and their ablation suppressed acetylation of lysine 18 within histone H3, and lysines 5, 8, 12, and 16 within histone H4, at the DSB sites.	Lysine	99-105	CREB binding protein	Homo sapiens	4-12
21217779-6	2011	The CBP/p300 proteins were recruited to sites of DSBs and their ablation suppressed acetylation of lysine 18 within histone H3, and lysines 5, 8, 12, and 16 within histone H4, at the DSB sites.	Lysine	132-139	CREB binding protein	Homo sapiens	4-12
21228036-0	2011	Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.	Lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	18-45
21573132-1	2011	Tumor suppressor gene CYLD is a deubiquitinating enzyme which negatively regulates various signaling pathways by removing the lysine 63-linked polyubiquitin chains from several specific substrates.	Lysine	126-132	TSC complex subunit 1	Homo sapiens	0-16
21412053-4	2011	TRAF6 also possesses E3 ubiquitin ligase activity causing lysine-63-linked polyubiquitination of target proteins.	Lysine	58-64	TNF receptor-associated factor 6	Mus musculus	0-5
21406961-2	2011	Mutation of the critical glutamate in Repeat III in the a 1S subunit of the skeletal L-type channel (Ca(v)1.1) to lysine virtually eliminates passage of Ca(2+) during step depolarizations.	Lysine	114-120	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	101-109
21460798-7	2011	Specific lysine insertion mutations within Acm1 promoted its ubiquitination by APC(Cdh1) whereas lysine removal from the APC substrate Hsl1 converted it into a potent APC(Cdh1) inhibitor.	Lysine	97-103	decapping enzyme, scavenger	Homo sapiens	135-139
21460798-8	2011	These findings suggest that tight Cdh1 binding combined with the inaccessibility of ubiquitinatable lysines contributes to pseudosubstrate inhibition of APC(Cdh1).	Lysine	100-107	cadherin 1	Homo sapiens	157-161
21433294-1	2011	Two MRI contrast agents (CAs) composed of Gd-DO3A conjugated to amino acid building blocks derived from glutamic acid (CA1) and lysine (CA2) have been synthesized by using novel alkyne and propionate linkers, and subsequently characterized.	Lysine	128-134	carbonic anhydrase 2	Rattus norvegicus	136-139
21367748-3	2011	EZH2, together with SUZ12 and EED, forms the polycomb repressive complex 2 (PRC2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	128-134	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21406964-4	2011	Increased enrichment of Polycomb Repressive Complex 2 (PRC2) and trimethylated Histone H3 Lys 27 (H3K27me3) at FLC chromatin is necessary for the stable maintenance of FLC repression by vernalization.	Lysine	90-93	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	111-114
21406964-4	2011	Increased enrichment of Polycomb Repressive Complex 2 (PRC2) and trimethylated Histone H3 Lys 27 (H3K27me3) at FLC chromatin is necessary for the stable maintenance of FLC repression by vernalization.	Lysine	90-93	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	168-171
21228036-1	2011	BACKGROUND: Enhancer of zeste homolog 2 is a component of the Polycomb repressive complex 2 that mediates chromatin-based gene silencing through trimethylation of lysine 27 on histone H3.	Lysine	163-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	12-39
21228036-4	2011	RESULTS: Significantly higher levels of Enhancer of zeste homolog 2 and RING1 and YY1 binding protein transcripts with enhanced levels of trimethylation of lysine 27 on histone H3 were found in adult T-cell leukemia/lymphoma cells compared with those in normal CD4(+) T cells.	Lysine	156-162	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	40-67
21228036-4	2011	RESULTS: Significantly higher levels of Enhancer of zeste homolog 2 and RING1 and YY1 binding protein transcripts with enhanced levels of trimethylation of lysine 27 on histone H3 were found in adult T-cell leukemia/lymphoma cells compared with those in normal CD4(+) T cells.	Lysine	156-162	YY1 transcription factor	Homo sapiens	82-85
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	arrestin beta 2	Homo sapiens	66-80
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	arrestin beta 2	Homo sapiens	170-184
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	arrestin beta 2	Homo sapiens	170-184
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	arrestin beta 2	Homo sapiens	170-184
21388957-6	2011	G116A mutation alone or combined with deletion of Lys(117) in GEC1 (GEC1-A) or Leu(117) in GABARAP (GABARAP-A) blocked their C-terminal cleavage, indicating that the conserved Gly(116) is necessary for C-terminal modification.	Lysine	50-53	GABA type A receptor associated protein like 1	Homo sapiens	62-66
21637793-2	2011	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown, in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	Lysine	252-258	homeobox C cluster	Homo sapiens	76-80
21428295-3	2011	Starting with the selective V1b agonist [deamino-Cys(1),Leu(4),Lys(8)]vasopressin (d[Leu(4),Lys(8)]VP) synthesized earlier, we added blue, green, or red fluorophores to the lysine residue at position 8 either directly or by the use of linkers of different lengths.	Lysine	63-66	arginine vasopressin	Homo sapiens	70-81
21428295-3	2011	Starting with the selective V1b agonist [deamino-Cys(1),Leu(4),Lys(8)]vasopressin (d[Leu(4),Lys(8)]VP) synthesized earlier, we added blue, green, or red fluorophores to the lysine residue at position 8 either directly or by the use of linkers of different lengths.	Lysine	92-95	arginine vasopressin	Homo sapiens	70-81
21513889-3	2011	p53 activation is dependent on lysine acetylation by the lysine acetyltransferase and transcriptional coactivator CREB-binding protein (CBP) and on acetylation-directed CBP recruitment for p53 target gene expression.	Lysine	31-37	tumor protein p53	Homo sapiens	0-3
21378168-1	2011	Tumor suppressor menin, the product of the MEN1 gene, plays a key role in controlling histone 3 lysine 4 trimethylation (H3K4me3) and gene transcription, which can regulate proliferation, apoptosis, and differentiation.	Lysine	96-102	menin 1	Homo sapiens	17-22
21378168-1	2011	Tumor suppressor menin, the product of the MEN1 gene, plays a key role in controlling histone 3 lysine 4 trimethylation (H3K4me3) and gene transcription, which can regulate proliferation, apoptosis, and differentiation.	Lysine	96-102	menin 1	Homo sapiens	43-47
21513889-3	2011	p53 activation is dependent on lysine acetylation by the lysine acetyltransferase and transcriptional coactivator CREB-binding protein (CBP) and on acetylation-directed CBP recruitment for p53 target gene expression.	Lysine	31-37	CREB binding protein	Homo sapiens	114-134
21321111-5	2011	The Akt Ser-473 phosphorylation promotes a Lys-48-linked polyubiquitination of Akt, resulting in its rapid proteasomal degradation.	Lysine	43-46	AKT serine/threonine kinase 1	Homo sapiens	4-7
21513889-3	2011	p53 activation is dependent on lysine acetylation by the lysine acetyltransferase and transcriptional coactivator CREB-binding protein (CBP) and on acetylation-directed CBP recruitment for p53 target gene expression.	Lysine	31-37	CREB binding protein	Homo sapiens	136-139
21321111-5	2011	The Akt Ser-473 phosphorylation promotes a Lys-48-linked polyubiquitination of Akt, resulting in its rapid proteasomal degradation.	Lysine	43-46	AKT serine/threonine kinase 1	Homo sapiens	79-82
21513889-3	2011	p53 activation is dependent on lysine acetylation by the lysine acetyltransferase and transcriptional coactivator CREB-binding protein (CBP) and on acetylation-directed CBP recruitment for p53 target gene expression.	Lysine	31-37	CREB binding protein	Homo sapiens	169-172
21504832-4	2011	Herein, we report that SirT1 controls global levels of Suv39h1 by increasing its half-life through inhibition of Suv39h1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2.	Lysine	121-127	SUV39H1 histone lysine methyltransferase	Homo sapiens	55-62
21504832-4	2011	Herein, we report that SirT1 controls global levels of Suv39h1 by increasing its half-life through inhibition of Suv39h1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2.	Lysine	121-127	SUV39H1 histone lysine methyltransferase	Homo sapiens	113-120
21526172-4	2011	The NT of Gap1 contains the acceptor lysines for ubiquitylation and its CT includes a sequence essential to exit from the endoplasmic reticulum (ER).	Lysine	37-44	amino acid permease GAP1	Saccharomyces cerevisiae S288C	10-14
21417280-1	2011	Proteins which bind methylated lysines ("readers" of the histone code) are important components in the epigenetic regulation of gene expression and can also modulate other proteins that contain methyl-lysine such as p53 and Rb.	Lysine	31-38	tumor protein p53	Homo sapiens	216-219
21473784-8	2011	Interestingly, we also discovered the association of NFI with the tri-methylation of lysine 9 of histone H3, a chromatin marker previously associated with the protection against silencing of telomeric genes by NFI.	Lysine	85-91	nuclear factor I C	Homo sapiens	53-56
21366335-3	2011	In alpha-amylases and ACE, removal of chloride from the binding site triggers formation of a salt bridge between the positively charged Arg or Lys residue involved in chloride binding and a nearby carboxylate residue.	Lysine	143-146	angiotensin I converting enzyme	Homo sapiens	22-25
21310926-6	2011	The functions of Kdm2b/Jhdm1b are mediated by its silencing of p15(Ink4b) expression through active demethylation of histone H3 lysine 36 dimethyl.	Lysine	128-134	cyclin dependent kinase inhibitor 2B	Homo sapiens	63-66
21310926-6	2011	The functions of Kdm2b/Jhdm1b are mediated by its silencing of p15(Ink4b) expression through active demethylation of histone H3 lysine 36 dimethyl.	Lysine	128-134	cyclin dependent kinase inhibitor 2B	Homo sapiens	67-72
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-208	nuclear receptor subfamily 3 group C member 1	Homo sapiens	177-200
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-207	nuclear receptor subfamily 3 group C member 1	Homo sapiens	177-200
21473784-8	2011	Interestingly, we also discovered the association of NFI with the tri-methylation of lysine 9 of histone H3, a chromatin marker previously associated with the protection against silencing of telomeric genes by NFI.	Lysine	85-91	nuclear factor I C	Homo sapiens	210-213
21423168-8	2011	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	Lysine	114-120	WD repeat domain 5	Homo sapiens	63-67
21188584-16	2011	MTP, MDP, and lysine-less PGN bind to TLR-2, 87-113.	Lysine	14-20	toll like receptor 2	Homo sapiens	38-43
21423168-8	2011	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	Lysine	114-120	WD repeat domain 5	Homo sapiens	37-41
21176092-10	2011	Furthermore, Sirt1 and HNF-1alpha co-localize on two HNF-1alpha binding sites on the Crp promoter, leading to decreased acetylation of lysine 16 of histone H4 at these sites only in response to nutrient restriction.	Lysine	135-141	HNF1 homeobox A	Homo sapiens	23-33
21176092-10	2011	Furthermore, Sirt1 and HNF-1alpha co-localize on two HNF-1alpha binding sites on the Crp promoter, leading to decreased acetylation of lysine 16 of histone H4 at these sites only in response to nutrient restriction.	Lysine	135-141	HNF1 homeobox A	Homo sapiens	53-63
21176092-10	2011	Furthermore, Sirt1 and HNF-1alpha co-localize on two HNF-1alpha binding sites on the Crp promoter, leading to decreased acetylation of lysine 16 of histone H4 at these sites only in response to nutrient restriction.	Lysine	135-141	C-reactive protein	Homo sapiens	85-88
21130870-0	2011	TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-kappaB activation.	Lysine	5-8	interleukin 1 beta	Mus musculus	45-53
21130870-0	2011	TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-kappaB activation.	Lysine	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
21130870-4	2011	However, the lysine site that mediates Lys63-linked TAK1 polyubiquitination in IL-1beta signaling is still controversial.	Lysine	13-19	interleukin 1 beta	Mus musculus	79-87
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	interleukin 1 beta	Mus musculus	71-79
21278251-4	2011	We have previously demonstrated that the second PHD finger of CHD4 binds peptides corresponding to the N terminus of histone H3 methylated at Lys(9).	Lysine	142-145	chromodomain helicase DNA binding protein 4	Homo sapiens	62-66
21168128-7	2011	RESULT(S): The patient had KS as a result of two missense mutations at exon 11 of KAL1 gene, 1690 G&gt;A and 1765 G&gt;A, a G A transition in codons 514 and 539, which resulted in the replacement of lysine by glutamic acid, respectively.	Lysine	199-205	anosmin 1	Homo sapiens	82-86
21306562-5	2011	Site-directed mutagenesis of the catalytic tetrad of AKR1B1, composed of Tyr, Lys, His and Asp, revealed that the triad of Asp43, Lys77 and His110, but not Tyr48, acts as a proton donor in most AKR activities, and is crucial for PGD(2) and PGF(2alpha) synthase activities.	Lysine	78-81	aldo-keto reductase family 1 member B	Homo sapiens	53-59
21241820-1	2011	Enhancer of zeste homolog 2 (EZH2) is a subunit of the Polycomb-Repressive Complex 2 (PRC2), which catalyses the trimethylation of histone H3 on Lys 27 (H3K27) and involves in genes repression.	Lysine	145-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
21241820-1	2011	Enhancer of zeste homolog 2 (EZH2) is a subunit of the Polycomb-Repressive Complex 2 (PRC2), which catalyses the trimethylation of histone H3 on Lys 27 (H3K27) and involves in genes repression.	Lysine	145-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
21278251-5	2011	Here, we determine the solution structure of PHD2 in complex with H3K9me3, revealing the molecular basis of histone recognition, including a cation-pi recognition mechanism for methylated Lys(9).	Lysine	188-191	egl-9 family hypoxia inducible factor 1	Homo sapiens	45-49
21465572-2	2011	In response to oxidative, nitrosative, and electrophilic insults, p53 undergoes post-translational modifications, such as oxidation and covalent modification of cysteines, nitration of tyrosines, acetylation of lysines, phosphorylation of serine/threonine residues, etc.	Lysine	211-218	tumor protein p53	Homo sapiens	66-69
21320024-5	2011	We also found that LSD1 demethylates E2F1 at lysine 185 and reduces E2F1-mediated cell death.	Lysine	45-51	lysine (K)-specific demethylase 1A L homeolog	Xenopus laevis	19-23
21247904-1	2011	EZH2, a catalytic subunit of Polycomb-repressive complex 2 (PRC2), is a histone lysine methyltransferase that methylates lysine 27 of histone H3, resulting in gene silencing.	Lysine	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21321083-4	2011	Recently, we showed that CpG island hypermethylation and epigenetic silencing of TMS1/ASC in human breast cancers are accompanied by a local shift from histone H4 lysine 16 acetylation (H4K16Ac) to H4 lysine 20 trimethylation (H4K20me3).	Lysine	163-169	PYD and CARD domain containing	Homo sapiens	81-85
21321083-4	2011	Recently, we showed that CpG island hypermethylation and epigenetic silencing of TMS1/ASC in human breast cancers are accompanied by a local shift from histone H4 lysine 16 acetylation (H4K16Ac) to H4 lysine 20 trimethylation (H4K20me3).	Lysine	163-169	PYD and CARD domain containing	Homo sapiens	86-89
21321083-4	2011	Recently, we showed that CpG island hypermethylation and epigenetic silencing of TMS1/ASC in human breast cancers are accompanied by a local shift from histone H4 lysine 16 acetylation (H4K16Ac) to H4 lysine 20 trimethylation (H4K20me3).	Lysine	201-207	PYD and CARD domain containing	Homo sapiens	81-85
21321083-4	2011	Recently, we showed that CpG island hypermethylation and epigenetic silencing of TMS1/ASC in human breast cancers are accompanied by a local shift from histone H4 lysine 16 acetylation (H4K16Ac) to H4 lysine 20 trimethylation (H4K20me3).	Lysine	201-207	PYD and CARD domain containing	Homo sapiens	86-89
21256156-1	2011	Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far.	Lysine	130-136	metadherin	Homo sapiens	54-79
21256156-1	2011	Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far.	Lysine	130-136	metadherin	Homo sapiens	81-86
21256156-1	2011	Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far.	Lysine	130-136	metadherin	Homo sapiens	163-168
21303901-4	2011	VPA seems to stabilize a specific acetyl modification (lysine 120) of the p53 tumor suppressor protein, resulting in an increase in its proapoptotic function at the mitochondrial membrane.	Lysine	55-61	tumor protein p53	Homo sapiens	74-77
21306448-2	2011	However, many bacteria, among them most of the major human pathogens, achieve CAMP resistance by MprF, a unique enzyme that modifies anionic phospholipids with l-lysine or l-alanine thereby introducing positive charges into the membrane surface and reducing the affinity for CAMPs.	Lysine	160-168	cathelicidin antimicrobial peptide	Homo sapiens	78-82
21220424-5	2011	In addition, HDAC6 deacetylates Tat at Lys-28 and thereby suppresses Tat-mediated transactivation of the HIV-1 promoter.	Lysine	39-42	histone deacetylase 6	Homo sapiens	13-18
21255632-3	2011	Using a recombinant bacterial expression assay we validated in vitro SUMOylation of the C-terminal domain of mGluR7 by both SUMO-1 and SUMO-2 and show that a single lysine residue (K889) in mGluR7 is required for SUMOylation.	Lysine	165-171	glutamate receptor, ionotropic, kainate 3	Mus musculus	109-115
21220424-7	2011	These findings establish HDAC6 as a Tat deacetylase and support a model in which Lys-28 deacetylation decreases Tat transactivation activity through affecting the ability of Tat to form a ribonucleoprotein complex with cyclin T1 and the transactivation-responsive RNA.	Lysine	81-84	histone deacetylase 6	Homo sapiens	25-30
21233208-5	2011	LC-MS/MS analysis and co-immunoprecipitation revealed that the target protein of DB16-1 was human LYRIC (lysine-rich CEACAM1 co-isolated).	Lysine	105-111	metadherin	Homo sapiens	98-103
21220424-7	2011	These findings establish HDAC6 as a Tat deacetylase and support a model in which Lys-28 deacetylation decreases Tat transactivation activity through affecting the ability of Tat to form a ribonucleoprotein complex with cyclin T1 and the transactivation-responsive RNA.	Lysine	81-84	cyclin T1	Homo sapiens	219-228
21057544-1	2011	Inducible acetylation of p53 at lysine residues has a great impact on regulating the transactivation of this protein, which is associated with cell growth arrest and/or apoptosis under various stress conditions.	Lysine	32-38	tumor protein p53	Homo sapiens	25-28
21445315-4	2011	Thus, in brm mutant plants FLC expression is elevated, and FLC chromatin exhibits increased levels of histone H3 lysine 4 tri-methylation and decreased levels of H3 lysine 27 tri-methylation, indicating that BRM imposes a repressive chromatin configuration at the FLC locus.	Lysine	113-119	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	59-62
21445315-4	2011	Thus, in brm mutant plants FLC expression is elevated, and FLC chromatin exhibits increased levels of histone H3 lysine 4 tri-methylation and decreased levels of H3 lysine 27 tri-methylation, indicating that BRM imposes a repressive chromatin configuration at the FLC locus.	Lysine	113-119	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	59-62
21445315-4	2011	Thus, in brm mutant plants FLC expression is elevated, and FLC chromatin exhibits increased levels of histone H3 lysine 4 tri-methylation and decreased levels of H3 lysine 27 tri-methylation, indicating that BRM imposes a repressive chromatin configuration at the FLC locus.	Lysine	165-171	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	59-62
21445315-4	2011	Thus, in brm mutant plants FLC expression is elevated, and FLC chromatin exhibits increased levels of histone H3 lysine 4 tri-methylation and decreased levels of H3 lysine 27 tri-methylation, indicating that BRM imposes a repressive chromatin configuration at the FLC locus.	Lysine	165-171	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	59-62
21177244-4	2011	Ala substitution of Lys(513), Lys(516), Glu(521), and Glu(535) markedly reduced MRP1 levels.	Lysine	20-23	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
21406556-8	2011	Interestingly, Cdc45 recruitment upon checkpoint bypass was accompanied by the restoration of global Cdk2 kinase activity and decrease in both global and origin-bound histone H3 Lys 4 trimethylation (H3K4me3), consistent with the suggestion that both of these factors are important for Cdc45 recruitment.	Lysine	178-181	cell division cycle 45	Homo sapiens	15-20
21322568-8	2011	MS analysis of the stacked spots revealed lactosylation of 9/15 lysines in beta-lactoglobulin and 8/12 lysines in alpha-lactalbumin.	Lysine	103-110	lactalbumin alpha	Homo sapiens	114-131
21325892-9	2011	Hypoxia prevents IkappaBalpha de-sumoylation of Sumo-2/3 chains on critical lysine residues, normally required for K-48 linked polyubiquitination.	Lysine	76-82	NFKB inhibitor alpha	Homo sapiens	17-29
20885444-4	2011	Mutation of Bax at lysine 128 (BaxK128E) abrogated its effects on Kv1.3 and the induction of apoptotic changes in mitochondria.	Lysine	19-25	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	66-71
21196497-6	2011	Mutating lysine to alanine or to arginine at Lys(588) and Lys(591) of Nrf2 resulted in decreased Nrf2-dependent gene transcription and abrogated the transcription-activating effect of CREB-binding protein.	Lysine	9-15	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
21196497-6	2011	Mutating lysine to alanine or to arginine at Lys(588) and Lys(591) of Nrf2 resulted in decreased Nrf2-dependent gene transcription and abrogated the transcription-activating effect of CREB-binding protein.	Lysine	9-15	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
21196497-6	2011	Mutating lysine to alanine or to arginine at Lys(588) and Lys(591) of Nrf2 resulted in decreased Nrf2-dependent gene transcription and abrogated the transcription-activating effect of CREB-binding protein.	Lysine	9-15	CREB binding protein	Homo sapiens	184-204
21196497-6	2011	Mutating lysine to alanine or to arginine at Lys(588) and Lys(591) of Nrf2 resulted in decreased Nrf2-dependent gene transcription and abrogated the transcription-activating effect of CREB-binding protein.	Lysine	45-48	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
21148411-8	2011	AII-induced ERK activation was reduced by &gt;65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1).	Lysine	195-201	angiotensinogen	Homo sapiens	0-3
21148411-8	2011	AII-induced ERK activation was reduced by &gt;65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1).	Lysine	195-201	mitogen-activated protein kinase 1	Homo sapiens	12-15
21376237-5	2011	The recognition of the acceptor ubiquitin surface around Lys11, but not around other lysines, generates a catalytically competent active site, which is composed of residues of both Ube2S and ubiquitin.	Lysine	85-92	ubiquitin conjugating enzyme E2 S	Homo sapiens	181-186
20977952-7	2011	The poly(HEMA)-lysine-modified surface was shown to reduce non-specific (fibrinogen) adsorption while binding plasminogen from plasma with high affinity.	Lysine	15-21	fibrinogen beta chain	Homo sapiens	73-83
21151202-1	2011	p53, NFkappaB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones.	Lysine	91-97	tumor protein p53	Homo sapiens	0-3
20885444-6	2011	To gain insight into the mechanism of Bax-Kv1.3 interaction, we mutated Glu158 of Bcl-x(L) (corresponding to K128 in Bax) to lysine.	Lysine	125-131	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	42-47
21151202-1	2011	p53, NFkappaB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones.	Lysine	91-97	nuclear factor kappa B subunit 1	Homo sapiens	5-13
21151202-1	2011	p53, NFkappaB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones.	Lysine	91-97	signal transducer and activator of transcription 3	Homo sapiens	15-20
21098725-2	2011	The IL-22-induced effects are mediated by STAT3, whose activity is proportional to acetylation in lysine (Lys)685 and phosphorylation in tyrosine (Tyr)705.	Lysine	98-104	signal transducer and activator of transcription 3	Homo sapiens	42-47
20962594-4	2011	HP1 contains a chromodomain that binds to di- and- tri-methylated lysine 9 of histone H3.	Lysine	66-72	Suppressor of variegation 205	Drosophila melanogaster	0-3
21098725-2	2011	The IL-22-induced effects are mediated by STAT3, whose activity is proportional to acetylation in lysine (Lys)685 and phosphorylation in tyrosine (Tyr)705.	Lysine	106-109	signal transducer and activator of transcription 3	Homo sapiens	42-47
21135039-1	2011	The SET1 family of methyltransferases carries out the bulk of histone H3 Lys-4 methylation in vivo.	Lysine	73-76	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	4-8
21098725-3	2011	Lys 685 acetylation of STAT3 is inhibited by sirtuin (SIRT)1, a class III deacetylase promoting keratinocyte differentiation.	Lysine	0-3	signal transducer and activator of transcription 3	Homo sapiens	23-28
21144910-4	2011	We now addressed the role of the two critical lysines not only in LRP binding but also in LRP-dependent endocytosis.	Lysine	46-53	LDL receptor related protein 1	Homo sapiens	66-69
21144910-4	2011	We now addressed the role of the two critical lysines not only in LRP binding but also in LRP-dependent endocytosis.	Lysine	46-53	LDL receptor related protein 1	Homo sapiens	90-93
21144910-3	2011	LDL receptor-related protein (LRP) mediates the cellular uptake of a multitude of ligands, some of which bind LRP with a relatively low affinity suggesting a suboptimal positioning of the two critical lysines.	Lysine	201-208	LDL receptor related protein 1	Homo sapiens	0-28
21144910-3	2011	LDL receptor-related protein (LRP) mediates the cellular uptake of a multitude of ligands, some of which bind LRP with a relatively low affinity suggesting a suboptimal positioning of the two critical lysines.	Lysine	201-208	LDL receptor related protein 1	Homo sapiens	30-33
21149597-5	2011	To shed light into the physiological role of YopE inactivation, we mutagenized the lysine polyubiquitin acceptor sites of YopE in the Y. enterocolitica serogroup O8 virulence plasmid.	Lysine	83-89	yopE	Yersinia enterocolitica	45-49
21149597-5	2011	To shed light into the physiological role of YopE inactivation, we mutagenized the lysine polyubiquitin acceptor sites of YopE in the Y. enterocolitica serogroup O8 virulence plasmid.	Lysine	83-89	yopE	Yersinia enterocolitica	122-126
21317535-5	2011	Expression of CSN6 appeared to prevent MDM2 autoubiquitination at lysine 364, resulting in stabilization of MDM2 and degradation of p53.	Lysine	66-72	COP9 signalosome subunit 6	Homo sapiens	14-18
21263074-9	2011	AAT decreased IkappaBalpha polyubiquitination linked through ubiquitin lysine residue 48 and increased ubiquitination linked through lysine residue 63.	Lysine	71-77	serpin family A member 1	Homo sapiens	0-3
21263074-9	2011	AAT decreased IkappaBalpha polyubiquitination linked through ubiquitin lysine residue 48 and increased ubiquitination linked through lysine residue 63.	Lysine	71-77	NFKB inhibitor alpha	Homo sapiens	14-26
21263074-9	2011	AAT decreased IkappaBalpha polyubiquitination linked through ubiquitin lysine residue 48 and increased ubiquitination linked through lysine residue 63.	Lysine	133-139	serpin family A member 1	Homo sapiens	0-3
21263074-10	2011	Moreover, lysine reside 63-linked Ub-IkappaBalpha degradation was substantially slower than lysine residue 48-linked Ub-IkappaBalpha in the presence of AAT, correlating altered ubiquitination with a prolonged IkappaBalpha t(1/2).	Lysine	10-16	NFKB inhibitor alpha	Homo sapiens	37-49
21273441-2	2011	We report that the androgen receptor (AR) is methylated at lysine-630 by Set9, which was originally identified as a histone H3K4 monomethyltransferase.	Lysine	59-65	androgen receptor	Homo sapiens	19-36
21321280-6	2011	METHODS: A series of recombinant derivatives of the HER2-binding Z(HER2)(:342) Affibody molecule with a C-terminal chelating sequence, -GXXC (X denoting glycine, serine, lysine, or glutamate), was designed.	Lysine	170-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-56
21214565-4	2011	As this motif is different in the two CBR subtypes, we mutated lysine 402 of CB(1)R into glycine, to obtain a cholesterol recognition/interaction amino acid sequence and consensus similar to that of CB(2)R. Both mutated and wild-type receptors were transiently expressed in human neuronal SH-SY5Y cells, and their localization and functioning were investigated using biochemical assays and immunofluorescence labelling.	Lysine	63-69	cannabinoid receptor 1	Homo sapiens	77-83
21273441-2	2011	We report that the androgen receptor (AR) is methylated at lysine-630 by Set9, which was originally identified as a histone H3K4 monomethyltransferase.	Lysine	59-65	androgen receptor	Homo sapiens	38-40
21148314-7	2011	Furthermore, brefeldin A and wortmannin treatment suggested that Lys-590 is required for BOR1 translocation from an early endosomal compartment to multivesicular bodies.	Lysine	65-68	HCO3- transporter family	Arabidopsis thaliana	89-93
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	101-104
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	185-199
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	201-204
20959290-4	2011	Methylation of the AR on lysine 632 is necessary for enhancing transcriptional activity of the receptor by facilitating both inter-domain communication between the N- and C-termini and recruitment to androgen-target genes.	Lysine	25-31	androgen receptor	Homo sapiens	19-21
21276103-0	2011	Transcription-dependence of histone H3 lysine 27 trimethylation at the Arabidopsis polycomb target gene FLC.	Lysine	39-45	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	104-107
21131586-3	2011	We found that tumor necrosis factor-alpha (TNF-alpha) SUMOylated MK2 at lysine (K)-339 affected EC actin filament organization and migration.	Lysine	72-78	tumor necrosis factor	Homo sapiens	14-41
21131586-3	2011	We found that tumor necrosis factor-alpha (TNF-alpha) SUMOylated MK2 at lysine (K)-339 affected EC actin filament organization and migration.	Lysine	72-78	tumor necrosis factor	Homo sapiens	43-52
21190999-3	2011	Surprisingly, B-cell lymphoma cell lines and lymphoma samples harboring heterozygous EZH2(Y641) mutations have increased levels of histone H3 Lys-27-specific trimethylation (H3K27me3).	Lysine	142-145	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	85-89
21177251-3	2011	Under low K(+) conditions, UbKO, a lysine-less mutant Ub that only supports monoubiquitination, preferentially interacted and selectively enhanced degradation of the mature hERG channels.	Lysine	35-41	ETS transcription factor ERG	Homo sapiens	173-177
21183685-2	2011	Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(428) promotes trafficking of activated receptors to the lysosomes for degradation.	Lysine	75-78	erythropoietin	Homo sapiens	66-69
21271695-5	2011	Utilizing a target structure-guided and computer-aided rational design approach, we developed a series of cyclic peptides with affinity for CBP BRD significantly greater than those of its biological ligands, including lysine-acetylated histones and tumor suppressor p53.	Lysine	218-224	CREB binding protein	Homo sapiens	140-143
21271695-6	2011	The best cyclopeptide of the series exhibited a K(d) of 8.0 muM, representing a 24-fold improvement in affinity over that of the linear lysine 382-acetylated p53 peptide.	Lysine	136-142	tumor protein p53	Homo sapiens	158-161
21177250-6	2011	Biomechanical studies revealed that lysine acetylation significantly decreased the K(m) for the actin-activated ATPase activity of both alpha- and beta-MHC isoforms.	Lysine	36-42	myosin heavy chain 6	Homo sapiens	136-155
21278485-1	2011	Histone H3 lysine 27 trimethylation (H3K27me3) catalyzed by the enzymatic subunit EZH2 in the Polycomb repressive complex 2 (PRC2) is essential for cells to "memorize" gene expression patterns through cell divisions and plays an important role in establishing and maintaining cell identity during development.	Lysine	11-17	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	82-86
21282606-0	2011	Nepsilon-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.	Lysine	9-15	gap junction protein, alpha 1	Mus musculus	93-104
21169561-3	2011	Pax3 acetylation on C-terminal lysine residues K437 and K475 may be critical for proper regulation of Hes1 and Neurog2.	Lysine	31-37	paired box 3	Mus musculus	0-4
21148320-7	2011	Specifically, acetylation of p53 at lysine 120, a DNA-binding domain residue mutated in human cancer, is essential for triggering apoptosis.	Lysine	36-42	tumor protein p53	Homo sapiens	29-32
21135092-6	2011	Filter binding assays demonstrated that deletion of the lysine-rich sequence at the C terminus of Rrp47 blocked RNA binding in vitro.	Lysine	56-62	Lrp1p	Saccharomyces cerevisiae S288C	98-103
21148320-9	2011	This analysis revealed that histone deacetylase 1 is predominantly responsible for the deacetylation of Lys(120).	Lysine	104-107	histone deacetylase 1	Homo sapiens	28-49
21167174-3	2011	PHF2, via its PHD, binds Lys4-trimethylated histone 3 in submicromolar affinity and has been reported to have the demethylase activity of monomethylated lysine 9 of histone 3 in vivo.	Lysine	153-159	PHD finger protein 2	Homo sapiens	0-4
21208003-7	2011	Coarse-grained and atomistic simulations furthermore elucidated the important role of lysine in facilitating Cyt C adsorption to MPMN surfaces.	Lysine	86-92	cytochrome c, somatic	Homo sapiens	109-114
20978007-6	2011	Sirt1 siRNA enhanced TF protein and mRNA expression, and this effect was reduced in NFkappaB/p65(-/-) mouse embryonic fibroblasts reconstituted with non-acetylatable Lys(310)-mutant NFkappaB/p65.	Lysine	166-169	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-92
21291527-1	2011	BACKGROUND: Methylation of histone H3 lysine 79 (H3K79) by Dot1 is highly conserved among species and has been associated with both gene repression and activation.	Lysine	38-44	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	59-63
21142150-2	2011	Residues Lys 24 and 32 in TSP1 and amino acids 24-26 and 32-34 in CRT have been shown through biochemical and cell-based approaches to be critical for TSP1-CRT binding and signaling.	Lysine	9-12	thrombospondin 1	Homo sapiens	26-30
21142150-2	2011	Residues Lys 24 and 32 in TSP1 and amino acids 24-26 and 32-34 in CRT have been shown through biochemical and cell-based approaches to be critical for TSP1-CRT binding and signaling.	Lysine	9-12	calreticulin	Homo sapiens	66-69
21142150-2	2011	Residues Lys 24 and 32 in TSP1 and amino acids 24-26 and 32-34 in CRT have been shown through biochemical and cell-based approaches to be critical for TSP1-CRT binding and signaling.	Lysine	9-12	thrombospondin 1	Homo sapiens	151-155
21142150-2	2011	Residues Lys 24 and 32 in TSP1 and amino acids 24-26 and 32-34 in CRT have been shown through biochemical and cell-based approaches to be critical for TSP1-CRT binding and signaling.	Lysine	9-12	calreticulin	Homo sapiens	156-159
21284855-4	2011	RESULTS: Using NMR spectroscopy we have determined distinct conformational changes in TDG upon either covalent sumoylation on lysine 330 or intermolecular SUMO-1 binding through a unique SUMO-binding motif (SBM) localized in the C-terminal region of TDG.	Lysine	126-132	thymine DNA glycosylase	Homo sapiens	86-89
21472584-6	2011	ECD of several b-ions from Substance P (RPKPQQFFGLM-NH(2)) showed series of c(m)-Lys fragment ions which suggested that the macro-cyclic structure may also be formed by connecting the C-terminal carbonyl group and the epsilon-amino group of the lysine side chain.	Lysine	81-84	tachykinin precursor 1	Homo sapiens	27-38
21189329-7	2011	The increased TGF-beta signaling due to SMAD7 reduction could be effectively inhibited by a novel clinically relevant TBRI (ALK5 kinase) inhibitor, LY-2157299.	Lysine	148-150	transforming growth factor, beta receptor I	Mus musculus	124-128
21289070-2	2011	One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L.	Lysine	31-34	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	90-94
21289070-2	2011	One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L.	Lysine	31-34	DOT1 like histone lysine methyltransferase	Homo sapiens	157-162
21472584-6	2011	ECD of several b-ions from Substance P (RPKPQQFFGLM-NH(2)) showed series of c(m)-Lys fragment ions which suggested that the macro-cyclic structure may also be formed by connecting the C-terminal carbonyl group and the epsilon-amino group of the lysine side chain.	Lysine	245-251	tachykinin precursor 1	Homo sapiens	27-38
21304947-2	2011	The chromo domain protein like heterochromatin protein1 (LHP1) is a subunit of a plant PRC1-like complex in Arabidopsis thaliana and recognizes histone H3 lysine 27 trimethylation, a silencing epigenetic mark deposited by the PRC2 complex.	Lysine	155-161	cellulose synthase 6	Arabidopsis thaliana	87-91
21257055-9	2011	In support of the increased yields of milk protein and lactose, mammary uptake of the group 2 AA (Ile, Leu, Lys, and Val) increased and the uptake:output ratio tended to increase from 1.04 to 1.23.	Lysine	108-111	Weaning weight-maternal milk	Bos taurus	38-42
21209336-8	2011	First, Urm1 is appended to lysine residues of three components that function in its own pathway (i.e., MOCS3, ATPBD3, and CTU2).	Lysine	27-33	cytosolic thiouridylase subunit 2	Homo sapiens	122-126
21245294-4	2011	This is caused by transcriptional induction of the KDM6A and KDM6B histone 3 lysine 27-specific demethylases.	Lysine	77-83	lysine demethylase 6A	Homo sapiens	51-56
21280121-4	2011	We here present a structure model of Arabidopsis thaliana Hsp21, obtained by homology modeling, single-particle electron microscopy, and lysine-specific chemical crosslinking.	Lysine	137-143	heat shock protein 21	Arabidopsis thaliana	58-63
21248752-4	2011	These genes encode enzymes that demethylate (UTX, JARID1C) or methylate (SETD2) key lysine residues of histone H3.	Lysine	84-90	lysine demethylase 6A	Homo sapiens	45-48
21283586-3	2011	The mechanism for this alkalinization-dependent gating has been proposed to be the neutralization of the side chain of a single arginine (lysine in TALK-2) residue near the pore of TASK-2, which occurs with the unusual pK(a) of 8.0.	Lysine	138-144	potassium two pore domain channel subfamily K member 17	Homo sapiens	148-154
21597201-2	2011	A [Lys(49)]PLA(2) called BPII induced cell death in human leukemia cells.	Lysine	3-6	phospholipase A2 group IB	Homo sapiens	11-17
20862685-1	2011	OBJECTIVE: To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes.	Lysine	49-55	interleukin 1 beta	Homo sapiens	80-97
20862685-1	2011	OBJECTIVE: To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes.	Lysine	49-55	interleukin 1 beta	Homo sapiens	99-107
20862685-1	2011	OBJECTIVE: To investigate the role of histone H3 lysine 4 (H3K4) methylation in interleukin-1beta (IL-1beta)-induced cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in human osteoarthritic (OA) chondrocytes.	Lysine	49-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	117-133
21307598-6	2011	In this study, we report that setd3 had lysine specificity toward histone H3K36.	Lysine	40-46	SET domain containing 3, actin histidine methyltransferase	Danio rerio	30-35
21238919-1	2011	The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	51-55
21167713-6	2011	Furthermore, we find that the binding of histone-interaction domains from BPTF, CHD1, and RAG2 to H3 lysine 4 trimethylation is also influenced by combinatorial PTMs.	Lysine	101-107	bromodomain PHD finger transcription factor	Homo sapiens	74-78
21127216-2	2011	In Arabidopsis, winter cold triggers enrichment of tri-methylated histone H3 Lys(27) at chromatin of the floral repressor, FLOWERING LOCUS C (FLC), and results in epigenetically stable repression of FLC.	Lysine	77-80	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	123-140
21127216-2	2011	In Arabidopsis, winter cold triggers enrichment of tri-methylated histone H3 Lys(27) at chromatin of the floral repressor, FLOWERING LOCUS C (FLC), and results in epigenetically stable repression of FLC.	Lysine	77-80	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	199-202
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	mitogen-activated protein kinase 8	Homo sapiens	134-137
20837137-0	2011	TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	5-11	transforming growth factor beta 1	Homo sapiens	32-40
20837137-0	2011	TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	5-11	mitogen-activated protein kinase 8	Homo sapiens	99-102
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	mitogen-activated protein kinase 14	Homo sapiens	142-145
20837137-3	2011	However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 polyubiquitination acceptor site in TGF-beta signaling pathway.	Lysine	34-40	transforming growth factor beta 1	Homo sapiens	116-124
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	transforming growth factor beta 1	Homo sapiens	55-63
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Lysine	228-234	protein regulator of cytokinesis 1	Mus musculus	120-131
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Lysine	228-234	cyclin dependent kinase inhibitor 2A	Mus musculus	170-173
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Lysine	228-234	cyclin dependent kinase inhibitor 2A	Mus musculus	174-179
21109933-2	2011	CYLD is a deubiquitinating enzyme acting as a negative regulator of the nuclear factor kappaB (NF-kappaB) signaling pathway by removing lysine-63-linked polyubiquitin chains from NF-kappaB activating proteins.	Lysine	136-142	nuclear factor kappa B subunit 1	Homo sapiens	95-104
21164265-3	2011	We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor.	Lysine	280-286	nuclear receptor subfamily 3 group C member 1	Homo sapiens	237-239
21164265-3	2011	We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor.	Lysine	308-314	nuclear receptor subfamily 3 group C member 1	Homo sapiens	237-239
21070394-2	2011	We have previously demonstrated the role of histone H3 methylation at lysine 27 (H3K27) by EZH2 methyltransferase in the regulation of gene expression during the critical period for the establishment of thermal control in chicks.	Lysine	70-76	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	91-95
21779481-12	2011	Induction of EPO under hypoxia was accompanied by increased histone H3 acetylation and reduced histone H3 lysine 9 trimethylation.	Lysine	106-112	erythropoietin	Homo sapiens	13-16
21109933-2	2011	CYLD is a deubiquitinating enzyme acting as a negative regulator of the nuclear factor kappaB (NF-kappaB) signaling pathway by removing lysine-63-linked polyubiquitin chains from NF-kappaB activating proteins.	Lysine	136-142	nuclear factor kappa B subunit 1	Homo sapiens	179-188
21197464-4	2011	JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27).	Lysine	176-182	protein regulator of cytokinesis 1	Mus musculus	64-68
21197464-4	2011	JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27).	Lysine	176-182	cyclin dependent kinase inhibitor 2A	Mus musculus	116-119
21197464-4	2011	JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27).	Lysine	176-182	cyclin dependent kinase inhibitor 2A	Mus musculus	120-125
20615470-3	2011	Lysine 51 is a highly conserved residue located in the RNA-binding region of Tat and the target of lysine methyltransferases KMT1E (SETDB1) and KMT7 (Set7/9).	Lysine	0-6	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	125-130
20821734-3	2011	Herein, we show that Tat acetylation at lysine-28 (K28) enhances its interaction with microtubules and increases its activity to promote microtubule assembly, by lowering the critical concentration of tubulin for polymerization into microtubules.	Lysine	40-46	keratin 28	Homo sapiens	51-54
20844090-3	2011	Lysine residues are potential sites for post-translational modification of IRF-7, and were suggested to be critical for its activity.	Lysine	0-6	interferon regulatory factor 7	Homo sapiens	75-80
20844090-4	2011	In this study, we analysed the 15 lysine residues for their effects on IRF-7 function by site-directed mutagenesis.	Lysine	34-40	interferon regulatory factor 7	Homo sapiens	71-76
20844090-7	2011	These findings demonstrate that the lysine residues of IRF-7 play important roles in mediating IFN synthesis and modulating viral lytic replication.	Lysine	36-42	interferon regulatory factor 7	Homo sapiens	55-60
22472282-7	2011	After lysine sufficiency, the expression of atrogin-1/MAFbx mRNA was decreased in gastrocnemius muscle (p&lt;0.05).	Lysine	6-12	F-box protein 32	Rattus norvegicus	44-53
22472282-7	2011	After lysine sufficiency, the expression of atrogin-1/MAFbx mRNA was decreased in gastrocnemius muscle (p&lt;0.05).	Lysine	6-12	F-box protein 32	Rattus norvegicus	54-59
20615470-3	2011	Lysine 51 is a highly conserved residue located in the RNA-binding region of Tat and the target of lysine methyltransferases KMT1E (SETDB1) and KMT7 (Set7/9).	Lysine	0-6	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	132-138
20306300-1	2011	The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin.	Lysine	137-143	lysyl oxidase like 2	Homo sapiens	4-24
21796528-4	2011	We have shown that AR is modified by SUMO-1 at two conserved lysine residues in its N-terminal domain.	Lysine	61-67	androgen receptor	Homo sapiens	19-21
20306300-1	2011	The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin.	Lysine	137-143	lysyl oxidase like 2	Homo sapiens	26-31
21818326-6	2011	This missense mutation replaces a glutamic acid residue with a lysine residue in the predicted protein, Polycystin 1.	Lysine	63-69	polycystin 1, transient receptor potential channel interacting	Canis lupus familiaris	104-116
20931131-1	2011	Upon genomic insult, the tumor suppressor p53 is phosphorylated and acetylated at specific serine and lysine residues, increasing its stability and transactivation function.	Lysine	102-108	tumor protein p53	Homo sapiens	42-45
21131960-1	2011	Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription.	Lysine	152-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-29
21131960-1	2011	Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription.	Lysine	152-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
21131967-0	2011	Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	26-35
21131967-0	2011	Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.	Lysine	0-6	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	52-57
21131967-0	2011	Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	148-157
22140559-6	2011	Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity.	Lysine	146-149	epidermal growth factor receptor	Homo sapiens	12-44
22140559-6	2011	Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity.	Lysine	146-149	epidermal growth factor receptor	Homo sapiens	46-50
22194861-1	2011	Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification.	Lysine	197-203	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	26-30
22043315-0	2011	Lysine 92 amino acid residue of USP46, a gene associated with "behavioral despair" in mice, influences the deubiquitinating enzyme activity.	Lysine	0-6	ubiquitin specific peptidase 46	Mus musculus	32-37
22043315-3	2011	Mice with a lysine codon (Lys 92) deletion in USP46 exhibited loss of "behavioral despair" under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system.	Lysine	12-18	ubiquitin specific peptidase 46	Mus musculus	46-51
22043315-3	2011	Mice with a lysine codon (Lys 92) deletion in USP46 exhibited loss of "behavioral despair" under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system.	Lysine	26-29	ubiquitin specific peptidase 46	Mus musculus	46-51
22043315-10	2011	These results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.	Lysine	31-34	ubiquitin specific peptidase 46	Mus musculus	50-55
21949728-6	2011	These data show that upon stimulation with IL-4 and an anti-CD40 antibody that mimics T cell help, the nucleosomes of the switch regions are highly modified on histone H3, accumulating acetylation marks and tri-methylation of lysine 4.	Lysine	226-232	interleukin 4	Homo sapiens	43-47
21876767-4	2011	KZNFs bind the KAP1 protein and direct KAP1 to specific DNA sequences where it suppresses gene expression by inducing localized heterochromatin characterized by histone 3 lysine 9 trimethylation (H3me3K9).	Lysine	171-177	tripartite motif containing 28	Homo sapiens	15-19
21876767-4	2011	KZNFs bind the KAP1 protein and direct KAP1 to specific DNA sequences where it suppresses gene expression by inducing localized heterochromatin characterized by histone 3 lysine 9 trimethylation (H3me3K9).	Lysine	171-177	tripartite motif containing 28	Homo sapiens	39-43
21931855-3	2011	It has been previously suggested that SUMOylation of lysine 51 (K51) of Nkx2-5 is essential for its DNA binding and transcriptional activation.	Lysine	53-59	NK2 homeobox 5	Homo sapiens	72-78
21701597-3	2011	Three PRC2 complexes have been identified and characterized in Arabidopsis; of these, the EMF and VRN complexes suppress flowering by catalyzing the trimethylation of lysine 27 on histone H3 of FLOWER LOCUS T (FT) and FLOWER LOCUS C (FLC).	Lysine	167-173	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	218-232
21701597-3	2011	Three PRC2 complexes have been identified and characterized in Arabidopsis; of these, the EMF and VRN complexes suppress flowering by catalyzing the trimethylation of lysine 27 on histone H3 of FLOWER LOCUS T (FT) and FLOWER LOCUS C (FLC).	Lysine	167-173	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	234-237
21687692-9	2011	Most of the reactive lysine and glutamine residues in SLPI are located in its first N-terminal elafin-like domain, while in trappin-2, they are located in both the N-terminal cementoin domain and the elafin moiety.	Lysine	21-27	secretory leukocyte peptidase inhibitor	Homo sapiens	54-58
21738601-0	2011	A ribosomal misincorporation of Lys for Arg in human triosephosphate isomerase expressed in Escherichia coli gives rise to two protein populations.	Lysine	32-35	triosephosphate isomerase 1	Homo sapiens	53-78
21058683-3	2010	As an example, reverse transcription of the HIV genome is primed by a human lysine-specific tRNA (tRNA(Lys3)) that is packaged (into the virion) by the HIV Gag protein with lysyl-tRNA synthetase (LysRS).	Lysine	76-82	mitochondrially encoded tRNA glycine	Homo sapiens	98-108
20943667-1	2010	SmyD1 is a cardiac- and muscle-specific histone methyltransferase that methylates histone H3 at lysine 4 and regulates gene transcription in early heart development.	Lysine	96-102	SET and MYND domain containing 1	Homo sapiens	0-5
20943667-5	2010	Importantly, our structural and functional analysis suggests that SmyD1 appears to be regulated by an autoinhibition mechanism, and that unusually spacious target lysine-access channel and the presence of the CTD domain both negatively contribute to the regulation of this cardiovascularly relevant methyltransferase.	Lysine	163-169	SET and MYND domain containing 1	Homo sapiens	66-71
21695268-11	2011	Thus, whereas arginine and lysine substitutions in Cgap1p and Yap1p proteins were reported as responsible for a specific YRE-O or YRE-A preference, our analyses rather suggest that the ancestral yeast AP-1 protein could recognize both YRE-O and YRE-A motifs and that the arginine/lysine exchange is not the only determinant of the specialization of modern Yaps for one motif or another.	Lysine	27-33	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	62-67
21695268-11	2011	Thus, whereas arginine and lysine substitutions in Cgap1p and Yap1p proteins were reported as responsible for a specific YRE-O or YRE-A preference, our analyses rather suggest that the ancestral yeast AP-1 protein could recognize both YRE-O and YRE-A motifs and that the arginine/lysine exchange is not the only determinant of the specialization of modern Yaps for one motif or another.	Lysine	280-286	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	62-67
21041298-4	2010	Our molecular analyses revealed that, in response to angiogenic signals, HIRA is induced in endothelial cells and mediates incorporation of lysine 56 acetylated histone H3.3 (H3acK56) at the chromatin domain of Vegfr1.	Lysine	140-146	fms related receptor tyrosine kinase 1	Homo sapiens	211-217
20940304-5	2010	CIP75 also binds to free monoubiquitin and lysine 48-linked tetraubiquitin chains in vitro and binds to ubiquitinated proteins in cellular lysates.	Lysine	43-49	ubiquilin 4	Homo sapiens	0-5
21172655-0	2010	Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.	Lysine	57-63	superoxide dismutase 2, mitochondrial	Mus musculus	78-83
20952395-1	2010	The multi-functional histone variant Htz1 (Saccharomyces cerevisiae H2A.Z) is acetylated on up to four N-terminal lysines at positions 3, 8, 10, and 14.	Lysine	114-121	histone H2AZ	Saccharomyces cerevisiae S288C	37-41
20952395-10	2010	In addition, each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetylated when this agent is removed.	Lysine	34-40	histone H2AZ	Saccharomyces cerevisiae S288C	18-22
21058683-3	2010	As an example, reverse transcription of the HIV genome is primed by a human lysine-specific tRNA (tRNA(Lys3)) that is packaged (into the virion) by the HIV Gag protein with lysyl-tRNA synthetase (LysRS).	Lysine	76-82	lysyl-tRNA synthetase 1	Homo sapiens	173-194
21058683-3	2010	As an example, reverse transcription of the HIV genome is primed by a human lysine-specific tRNA (tRNA(Lys3)) that is packaged (into the virion) by the HIV Gag protein with lysyl-tRNA synthetase (LysRS).	Lysine	76-82	lysyl-tRNA synthetase 1	Homo sapiens	196-201
21098266-6	2010	Molecularly, Sirt6 deletion results in striking hyperacetylation of histone H3 lysine 9 (H3K9) and lysine 56 (H3K56), two chromatin marks implicated in the regulation of gene activity and chromatin structure, in various brain regions including those involved in neuroendocrine regulation.	Lysine	79-85	sirtuin 6	Mus musculus	13-18
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	MLLT3 super elongation complex subunit	Homo sapiens	140-143
21167755-3	2010	RAUL limited type I IFN production by directly catalyzing lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed by proteasome-dependent degradation.	Lysine	58-64	interferon alpha 1	Homo sapiens	20-23
21167755-3	2010	RAUL limited type I IFN production by directly catalyzing lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed by proteasome-dependent degradation.	Lysine	58-64	interferon regulatory factor 7	Homo sapiens	102-132
21167755-3	2010	RAUL limited type I IFN production by directly catalyzing lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed by proteasome-dependent degradation.	Lysine	58-64	interferon regulatory factor 7	Homo sapiens	134-138
21098664-7	2010	We conclude that the lysine methylation of promoter-bound STAT3 leads to biologically important down-regulation of the dependent responses and that SET9, which is known to help provide an activating methylation mark to H3K4, is recruited to the newly activated SOCS3 promoter by STAT3.	Lysine	21-27	signal transducer and activator of transcription 3	Homo sapiens	58-63
21179466-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Using a transgenic RNA-interference strategy to selectively silence CBP, Psn, and Notch in adult Drosophila, we provide evidence for the first time that Psn is required for normal CBP levels and for maintaining specific global acetylations at lysine 8 of histone 4 (H4K8ac) in the central nervous system (CNS).	Lysine	275-281	Presenilin	Drosophila melanogaster	185-188
21098266-6	2010	Molecularly, Sirt6 deletion results in striking hyperacetylation of histone H3 lysine 9 (H3K9) and lysine 56 (H3K56), two chromatin marks implicated in the regulation of gene activity and chromatin structure, in various brain regions including those involved in neuroendocrine regulation.	Lysine	99-105	sirtuin 6	Mus musculus	13-18
20824693-1	2010	An efficient strategy is reported to introduce methacrylamide groups on the lysine residues of a model protein (lysozyme) for immobilization and triggered release from a hydrogel network.	Lysine	76-82	lysozyme	Homo sapiens	112-120
21151599-14	2010	FDP-lysine accumulation was associated with the induction of HO-1, no change in GFAP, a decrease in protein levels of the potassium channel subunit Kir4.1, and upregulation of transcripts for VEGF, IL-6, and TNF-alpha.	Lysine	4-10	vascular endothelial growth factor A	Homo sapiens	192-196
21078963-0	2010	Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	48-52
21078963-1	2010	EZH2, the catalytic subunit of the PRC2 complex, catalyzes the mono- through trimethylation of lysine 27 on histone H3 (H3K27).	Lysine	95-101	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21151599-14	2010	FDP-lysine accumulation was associated with the induction of HO-1, no change in GFAP, a decrease in protein levels of the potassium channel subunit Kir4.1, and upregulation of transcripts for VEGF, IL-6, and TNF-alpha.	Lysine	4-10	interleukin 6	Homo sapiens	198-202
21151599-14	2010	FDP-lysine accumulation was associated with the induction of HO-1, no change in GFAP, a decrease in protein levels of the potassium channel subunit Kir4.1, and upregulation of transcripts for VEGF, IL-6, and TNF-alpha.	Lysine	4-10	tumor necrosis factor	Homo sapiens	208-217
21109198-6	2010	SIRT3 deacetylates two critical lysine residues on SOD2 and promotes its antioxidative activity.	Lysine	32-38	superoxide dismutase 2, mitochondrial	Mus musculus	51-55
21212461-0	2010	Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.	Lysine	66-72	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	58-62
21212461-3	2010	Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding site of cyclosporine A, a CypD inhibitor.	Lysine	132-138	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	108-121
21212461-3	2010	Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding site of cyclosporine A, a CypD inhibitor.	Lysine	132-138	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	123-127
21212461-3	2010	Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding site of cyclosporine A, a CypD inhibitor.	Lysine	132-138	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	194-198
21154170-1	2010	Dulaglutide (LY-2189265) is a novel, long-acting glucagon-like peptide 1 (GLP-1) analog being developed by Eli Lilly for the treatment of type 2 diabetes mellitus (T2DM).	Lysine	13-15	glucagon	Homo sapiens	49-72
21154170-1	2010	Dulaglutide (LY-2189265) is a novel, long-acting glucagon-like peptide 1 (GLP-1) analog being developed by Eli Lilly for the treatment of type 2 diabetes mellitus (T2DM).	Lysine	13-15	glucagon	Homo sapiens	74-79
21123648-1	2010	Ezh2 functions as a histone H3 Lys 27 (H3K27) methyltransferase when comprising the Polycomb-Repressive Complex 2 (PRC2).	Lysine	31-34	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	56-62	glutathione peroxidase	Saccharomyces cerevisiae S288C	86-91
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	56-62	glutathione peroxidase	Saccharomyces cerevisiae S288C	111-116
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	72-78	glutathione peroxidase	Saccharomyces cerevisiae S288C	86-91
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	72-78	glutathione peroxidase	Saccharomyces cerevisiae S288C	111-116
21078122-7	2010	These observations strongly suggest that lysine 339 and its flanking amino acid stretches are involved in the interaction between Ure2p and Ssa1p.	Lysine	41-47	glutathione peroxidase	Saccharomyces cerevisiae S288C	130-135
20930066-3	2010	Here, we examined the role of epigenetic chromatin marks such as histone H3 lysine methylation (H3Kme) in TGF-beta1-induced gene expression in rat mesangial cells under normal and high-glucose (HG) conditions.	Lysine	76-82	transforming growth factor, beta 1	Rattus norvegicus	106-115
20919753-8	2010	The docking studies show binding of BH3 domain at Lys 110, Trp-111, Pro-115, Glu-119 and Asp-127 in the groove of BH 1, 2 and 3 domains of Bcl-2L10.	Lysine	50-53	BCL2 like 10	Homo sapiens	139-147
21115697-0	2010	A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.	Lysine	9-15	stromal interaction molecule 1	Homo sapiens	84-89
21084562-2	2010	In contrast to yeast, flies, and humans where a single Dot1 enzyme is responsible for all methylation of H3 lysine 79 (H3K79), African trypanosomes express two DOT1 proteins that methylate histone H3K76 (corresponding to H3K79 in other organisms) in a cell-cycle-regulated manner.	Lysine	108-114	DOT1 like histone lysine methyltransferase	Homo sapiens	55-59
21084562-2	2010	In contrast to yeast, flies, and humans where a single Dot1 enzyme is responsible for all methylation of H3 lysine 79 (H3K79), African trypanosomes express two DOT1 proteins that methylate histone H3K76 (corresponding to H3K79 in other organisms) in a cell-cycle-regulated manner.	Lysine	108-114	DOT1 like histone lysine methyltransferase	Homo sapiens	160-164
21115743-2	2010	When present in PRC2, EZH2 catalyzes trimethylation on lysine 27 residue of histone H3 (H3K27Me3), resulting in epigenetic silencing of gene expression.	Lysine	55-61	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
21085495-3	2010	We have focused our interest on the epigenetic modulator HP1gamma (Heterochromatin Protein 1, isoform gamma) that binds histones H3 methylated at lysine 9 (meH3K9) and is highly plastic in its distribution and association with the transcriptional regulation of specific genes during cell fate transitions.	Lysine	146-152	chromobox 3	Mus musculus	57-65
20619282-0	2010	Lysine 419 targets human glucocorticoid receptor for proteasomal degradation.	Lysine	0-6	nuclear receptor subfamily 3 group C member 1	Homo sapiens	25-48
20837482-3	2010	In this study, we performed extensive substituted cysteine-scanning mutagenesis analysis of the C-terminal region of NBCe1-A covering amino acids Ala(800)-Lys(967).	Lysine	155-158	solute carrier family 4 member 4	Homo sapiens	117-124
21124883-2	2010	The Notch1 receptor was proposed to be monoubiquitinated before its gamma-secretase cleavage; the targeted lysine has been localized to its submembrane domain.	Lysine	107-113	notch receptor 1	Homo sapiens	4-10
21124902-1	2010	Histone H3 lysine 4 (K4) methylation is a prevalent mark associated with transcription activation and is mainly catalyzed by the MLL/SET1 family histone methyltransferases.	Lysine	11-17	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	133-137
21041680-4	2010	One interesting example of the complexity of ubiquitin signaling is the Saccharomyces cerevisiae transcription factor Met4, which is regulated by a single lysine-48 linked polyubiquitin chain that can directly repress activity of Met4 or induce degradation by the proteasome.	Lysine	155-161	Met4p	Saccharomyces cerevisiae S288C	118-122
21041680-4	2010	One interesting example of the complexity of ubiquitin signaling is the Saccharomyces cerevisiae transcription factor Met4, which is regulated by a single lysine-48 linked polyubiquitin chain that can directly repress activity of Met4 or induce degradation by the proteasome.	Lysine	155-161	Met4p	Saccharomyces cerevisiae S288C	230-234
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	keratin 25	Homo sapiens	74-77
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	keratin 32	Homo sapiens	92-95
20798234-2	2010	Disruptor of telomere silencing 1-like (DOT1L) is a unique histone methyltransferase that specifically methylates histone H3 at lysine 79.	Lysine	128-134	DOT1 like histone lysine methyltransferase	Homo sapiens	40-45
20798234-8	2010	These data suggest a model whereby DOT1L-dependent lysine 79 of histone H3 methylation serves as a critical regulator of a differentiation switch during early hematopoiesis, regulating steady-state levels of GATA2 and PU.1 transcription, thus controlling numbers of circulating erythroid and myeloid cells.	Lysine	51-57	DOT1 like histone lysine methyltransferase	Homo sapiens	35-40
20826784-3	2010	Here we show that nuclear accumulation of survivin is promoted by CREB-binding protein (CBP)-dependent acetylation on lysine 129 (129K, Lys-129).	Lysine	118-124	CREB binding protein	Homo sapiens	66-86
20826784-3	2010	Here we show that nuclear accumulation of survivin is promoted by CREB-binding protein (CBP)-dependent acetylation on lysine 129 (129K, Lys-129).	Lysine	118-124	CREB binding protein	Homo sapiens	88-91
20962278-3	2010	PRLR-recruited CREB-binding protein (CBP) acetylates multiple lysine sites randomly distributed along the cytoplasmic loop of PRLR.	Lysine	62-68	CREB binding protein	Homo sapiens	15-35
20826784-3	2010	Here we show that nuclear accumulation of survivin is promoted by CREB-binding protein (CBP)-dependent acetylation on lysine 129 (129K, Lys-129).	Lysine	136-139	CREB binding protein	Homo sapiens	66-86
20826784-3	2010	Here we show that nuclear accumulation of survivin is promoted by CREB-binding protein (CBP)-dependent acetylation on lysine 129 (129K, Lys-129).	Lysine	136-139	CREB binding protein	Homo sapiens	88-91
20974913-10	2010	These novel findings uncover an exclusive role for H3 lysine 14 acetylation in facilitating the ATP-independent and transcription-independent disassembly of promoter nucleosomes by Nap1.	Lysine	54-60	nucleosome assembly protein 1 like 1	Homo sapiens	181-185
21062452-1	2010	BACKGROUND: In male Drosophila melanogaster, the male specific lethal (MSL) complex is somehow responsible for a two-fold increase in transcription of most X-linked genes, which are enriched for histone H4 acetylated at lysine 16 (H4K16ac).	Lysine	220-226	male-specific lethal 1	Drosophila melanogaster	71-74
20962278-3	2010	PRLR-recruited CREB-binding protein (CBP) acetylates multiple lysine sites randomly distributed along the cytoplasmic loop of PRLR.	Lysine	62-68	CREB binding protein	Homo sapiens	37-40
20855524-5	2010	ANCCA preferentially associates via its bromodomain with H3 acetylated at lysine 14 (H3K14ac) and is required for key cell cycle gene expression and cancer cell proliferation.	Lysine	74-80	ATPase family AAA domain containing 2	Homo sapiens	0-5
21115916-3	2010	RESULTS: LY/Api synergistically induced apoptosis in leukaemia cells, especially CD34(+)CD38(-) leukaemia cells.	Lysine	9-11	CD34 molecule	Homo sapiens	81-85
20861184-3	2010	It has also been shown that MDR1 activation is accompanied by increased methylation on lysine 4 of histone H3 (H3K4).	Lysine	87-93	ATP binding cassette subfamily B member 1	Homo sapiens	28-32
20833801-2	2010	In this study, the ldcA gene (lysine decarboxylase A; PA1818), previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism in this organism.	Lysine	167-175	lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA	Pseudomonas aeruginosa PAO1	19-23
20833801-3	2010	LdcA was purified to homogeneity from a recombinant strain of Escherichia coli, and the results of enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-lysine, but not L-arginine, as a substrate.	Lysine	194-202	lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA	Pseudomonas aeruginosa PAO1	0-4
20805357-5	2010	Moreover, HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo.	Lysine	81-87	YY1 transcription factor	Homo sapiens	52-55
20805357-5	2010	Moreover, HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo.	Lysine	81-87	BRCA1 associated protein 1	Homo sapiens	169-173
20935635-1	2010	The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing.	Lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-63
20935635-1	2010	The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing.	Lysine	118-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	65-69
21060834-0	2010	Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.	Lysine	64-70	cyclin dependent kinase inhibitor 2A	Homo sapiens	80-83
20732871-5	2010	Cells lacking Leo1 have reduced Paf1C recruitment as well as decreased levels of histone H3 and trimethylated H3 Lys(4) within transcribed chromatin.	Lysine	113-116	Leo1p	Saccharomyces cerevisiae S288C	14-18
20738173-1	2010	The pathway involving Bre1-dependent monoubiquitination of histone H2B lysine 123, which leads to Dot1-dependent methylation of histone H3 lysine 79 (H3K79me2), has been implicated in survival after exposure to ionizing radiation in Saccharomyces cerevisiae.	Lysine	71-77	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	98-102
20738173-1	2010	The pathway involving Bre1-dependent monoubiquitination of histone H2B lysine 123, which leads to Dot1-dependent methylation of histone H3 lysine 79 (H3K79me2), has been implicated in survival after exposure to ionizing radiation in Saccharomyces cerevisiae.	Lysine	139-145	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	98-102
20801885-6	2010	The interaction with beta-COP was reduced by mutating a dibasic motif at Lys(54) in the Na,K-ATPase alpha-subunit.	Lysine	73-76	COPI coat complex subunit beta 2	Homo sapiens	21-29
20933424-2	2010	In animals, the two best-characterized PcG complexes are PRC2 and PRC1, which respectively possess histone 3 lysine 27 (H3K27) trimethyltransferase [2-4] and histone 2A lysine 119 (H2AK119) E3 ubiquitin ligase activities [5-7].	Lysine	109-115	cellulose synthase 6	Arabidopsis thaliana	66-70
20933424-2	2010	In animals, the two best-characterized PcG complexes are PRC2 and PRC1, which respectively possess histone 3 lysine 27 (H3K27) trimethyltransferase [2-4] and histone 2A lysine 119 (H2AK119) E3 ubiquitin ligase activities [5-7].	Lysine	169-175	cellulose synthase 6	Arabidopsis thaliana	66-70
20833138-3	2010	Here we identify that lysine specific demethylase 1, (LSD1) is responsible for removing the repressive histone codes during C2C12 mouse myoblast differentiation.	Lysine	22-28	lysine (K)-specific demethylase 1A	Mus musculus	54-58
20650902-10	2010	On the other hand, point mutations of residues in the C-terminal leucine-rich repeat domain of Tmod3 (Lys-317 in the fifth leucine-rich repeat beta-sheet and Lys-344 or Arg-345/Arg-346 in the C-terminal alpha6-helix) significantly reduced pointed end-capping and nucleation without altering actin monomer binding.	Lysine	102-105	tropomodulin 3	Homo sapiens	95-100
20650902-10	2010	On the other hand, point mutations of residues in the C-terminal leucine-rich repeat domain of Tmod3 (Lys-317 in the fifth leucine-rich repeat beta-sheet and Lys-344 or Arg-345/Arg-346 in the C-terminal alpha6-helix) significantly reduced pointed end-capping and nucleation without altering actin monomer binding.	Lysine	158-161	tropomodulin 3	Homo sapiens	95-100
20678559-9	2010	Finally, o,p"-DDT induction of aromatase was inhibited by various inhibitors [COX-2 (by NS-398), PKA (H-89), PI3-K/Akt (LY 294002), EP2 (AH6809), and EP4 receptor (AH23848)].	Lysine	120-122	AKT serine/threonine kinase 1	Homo sapiens	115-118
20966256-5	2010	Pias1 deletion caused promoter demethylation, reduced histone H3 methylation at Lys(9), and enhanced promoter accessibility.	Lysine	80-83	protein inhibitor of activated STAT 1	Mus musculus	0-5
20592021-9	2010	The labeling data account for 51 of the 73 lysine residues of C1r and C1s.	Lysine	43-49	complement C1r	Homo sapiens	62-65
20921420-5	2010	A positively charged lysine residue at position 65 of claudin-4 was critical for its anion selectivity.	Lysine	21-27	claudin 4	Mus musculus	54-63
20592021-9	2010	The labeling data account for 51 of the 73 lysine residues of C1r and C1s.	Lysine	43-49	complement C1s	Homo sapiens	70-73
20675387-0	2010	Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.	Lysine	130-136	p53	Drosophila melanogaster	11-14
20667822-5	2010	The cofactor and substrate binding sites of human TKT bear high resemblance to those of other TKTs but also feature unique properties, including two lysines and a serine that interact with the beta-phosphate of ThDP.	Lysine	149-156	transketolase	Homo sapiens	50-53
20720257-10	2010	Serum ferritin (P = 0.045) and C-reactive protein (P = 0.018) decreased in lysine-supplemented women but increased in placebo-supplemented women.	Lysine	75-81	C-reactive protein	Homo sapiens	31-49
20809635-8	2010	The negatively charged residues of the EEVD motif in the octapeptide form electrostatic interactions with the positively charged Lys residues of CTD.	Lysine	129-132	CTD	Homo sapiens	145-148
20569236-5	2010	Short-term p16 expression increases the amount of histone H3 trimethylated on lysine 27 (H3K27) bound to the hTERT promoter, resulting in transcriptional silencing, likely mediated by polycomb complexes.	Lysine	78-84	cyclin dependent kinase inhibitor 2A	Homo sapiens	11-14
20674515-6	2010	We demonstrate that the Dot1-dependent status of H3K79 methylation modulates the resistance to the alkylating agent MMS, which depends on PCNA ubiquitylation at lysine 164.	Lysine	161-167	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	24-28
20705923-6	2010	METHODS AND RESULTS: Low concentrations of aspirin induce lysine acetylation of eNOS, stimulating eNOS enzymatic activity and endothelial NO production in a cyclooxygenase-1-independent fashion.	Lysine	58-64	nitric oxide synthase 3	Homo sapiens	80-84
20609472-3	2010	Animal derived tissue transglutaminase (tTG) and recombinant human transglutaminase (hTG) enzymes were used for coupling two classes of protein polymers containing either lysine or glutamine, which have the recognition substrates for enzymatic crosslinking evenly spaced along the protein backbone.	Lysine	171-177	transglutaminase 2	Homo sapiens	15-38
20609472-3	2010	Animal derived tissue transglutaminase (tTG) and recombinant human transglutaminase (hTG) enzymes were used for coupling two classes of protein polymers containing either lysine or glutamine, which have the recognition substrates for enzymatic crosslinking evenly spaced along the protein backbone.	Lysine	171-177	transglutaminase 2	Homo sapiens	40-43
20705923-0	2010	Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.	Lysine	118-124	nitric oxide synthase 3	Homo sapiens	140-173
20705923-5	2010	OBJECTIVE: To determine the role of lysine acetylation of endothelial nitric oxide synthase (eNOS) in the regulation of endothelial NO production by low-dose aspirin and to examine whether the lysine deacetylase histone deacetylase (HDAC)3 antagonizes the effect of low-dose aspirin on endothelial NO production by reversing acetylation of functionally critical eNOS lysine residues.	Lysine	36-42	nitric oxide synthase 3	Homo sapiens	58-91
20705923-5	2010	OBJECTIVE: To determine the role of lysine acetylation of endothelial nitric oxide synthase (eNOS) in the regulation of endothelial NO production by low-dose aspirin and to examine whether the lysine deacetylase histone deacetylase (HDAC)3 antagonizes the effect of low-dose aspirin on endothelial NO production by reversing acetylation of functionally critical eNOS lysine residues.	Lysine	36-42	nitric oxide synthase 3	Homo sapiens	93-97
20705923-9	2010	Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production.	Lysine	0-6	calmodulin 1	Homo sapiens	18-28
20705923-9	2010	Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production.	Lysine	0-6	nitric oxide synthase 3	Bos taurus	61-65
20705923-9	2010	Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production.	Lysine	0-6	nitric oxide synthase 3	Bos taurus	105-109
20705923-9	2010	Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production.	Lysine	0-6	calmodulin	Bos taurus	113-123
20705923-9	2010	Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production.	Lysine	0-6	nitric oxide synthase 3	Bos taurus	105-109
20705923-10	2010	HDAC3 inhibits aspirin-stimulated (1) lysine acetylation of eNOS, (2) eNOS enzymatic activity, (3) eNOS-derived NO, and (4) binding of eNOS to calmodulin.	Lysine	38-44	nitric oxide synthase 3	Homo sapiens	60-64
20705923-11	2010	Conversely, downregulation of HDAC3 promotes lysine acetylation of eNOS and endothelial NO generation.	Lysine	45-51	nitric oxide synthase 3	Homo sapiens	67-71
20705923-12	2010	CONCLUSIONS: Lysine acetylation of eNOS is a posttranslational protein modification supporting low-dose aspirin-induced vasoprotection.	Lysine	13-19	nitric oxide synthase 3	Homo sapiens	35-39
20601085-3	2010	The GAPDH-Siah interaction depends on the integrity of lysine 227 in human GAPDH, being the mutant K227A unable to associate with Siah.	Lysine	55-61	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	4-9
20601085-3	2010	The GAPDH-Siah interaction depends on the integrity of lysine 227 in human GAPDH, being the mutant K227A unable to associate with Siah.	Lysine	55-61	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-80
20601085-8	2010	By spot mapping analysis we first identified Lys 117 and 251 as the putative GAPDH residues that could be acetylated by PCAF.	Lysine	45-48	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	77-82
20601085-10	2010	Finally, we identified Lys 227 as a third GAPDH residue whose acetylation is needed for its transport from cytoplasm to the nucleus.	Lysine	23-26	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
20601085-11	2010	Thus, results reported here indicate that nuclear translocation of GAPDH is mediated by acetylation of three specific Lys residues (117, 227 and 251 in human cells).	Lysine	118-121	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	67-72
20826464-2	2010	We have recently described a new form of post-translational regulation of the membrane protein beta-site APP cleaving enzyme 1 (BACE1) involving transient lysine acetylation in the lumen of the endoplasmic reticulum (ER).	Lysine	155-161	beta-secretase 1	Homo sapiens	95-126
20826464-2	2010	We have recently described a new form of post-translational regulation of the membrane protein beta-site APP cleaving enzyme 1 (BACE1) involving transient lysine acetylation in the lumen of the endoplasmic reticulum (ER).	Lysine	155-161	beta-secretase 1	Homo sapiens	128-133
20682767-6	2010	We show that ZFP91 interacts with and promotes the Lys(63)-linked ubiquitination of NIK and subsequent processing of p100 to p52.	Lysine	51-54	zinc finger protein 91	Homo sapiens	13-18
20525793-0	2010	PARP1 ADP-ribosylates lysine residues of the core histone tails.	Lysine	22-28	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
20558222-8	2010	This process was inhibited by substrates of cationic amino acid transporter (CAT)s, such as L-arginine, L-lysine, and L-ornithine.	Lysine	104-112	catalase	Rattus norvegicus	77-80
20686027-8	2010	Concordant with prior studies, a lysine at position 26 proved essential for A3G neutralization.	Lysine	33-39	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	76-79
20696840-7	2010	We show that this results from IkappaBalpha sumoylation by Sumo-2/3 on critical lysine residues, normally required for K-48-linked polyubiquitination.	Lysine	80-86	NFKB inhibitor alpha	Homo sapiens	31-43
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	53-56	mitogen-activated protein kinase kinase 7	Homo sapiens	19-22
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	53-56	mitogen-activated protein kinase 1	Homo sapiens	23-26
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	mitogen-activated protein kinase kinase 7	Homo sapiens	19-22
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	mitogen-activated protein kinase 1	Homo sapiens	23-26
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	mitogen-activated protein kinase kinase 7	Homo sapiens	19-22
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	mitogen-activated protein kinase 1	Homo sapiens	23-26
20525793-6	2010	Taken together, our computational and experimental results provide strong evidence that PARP1 modifies important regulatory lysines of the core histone tails.	Lysine	124-131	poly(ADP-ribose) polymerase 1	Homo sapiens	88-93
20669242-5	2010	These domains are known to recognize methylated lysine or arginine residues and could contribute to targeting of Pcl-PRC2.	Lysine	48-54	Polycomblike	Drosophila melanogaster	113-116
20603168-4	2010	Increasing the cationicity of alyteserin-1c by the substitution Glu(4) Lys enhanced the potency against MDRAB (MIC=1.25-5 muM; MBC=1.25-5 muM) as well as decreasing hemolytic activity (HC(50)&gt;400 muM).	Lysine	71-74	latexin	Homo sapiens	122-125
20603168-4	2010	Increasing the cationicity of alyteserin-1c by the substitution Glu(4) Lys enhanced the potency against MDRAB (MIC=1.25-5 muM; MBC=1.25-5 muM) as well as decreasing hemolytic activity (HC(50)&gt;400 muM).	Lysine	71-74	latexin	Homo sapiens	138-141
20603168-4	2010	Increasing the cationicity of alyteserin-1c by the substitution Glu(4) Lys enhanced the potency against MDRAB (MIC=1.25-5 muM; MBC=1.25-5 muM) as well as decreasing hemolytic activity (HC(50)&gt;400 muM).	Lysine	71-74	latexin	Homo sapiens	138-141
20669242-7	2010	Pcl-Tudor contains an atypical, incomplete aromatic cage that does not interact with known Tudor domain ligands, such as methylated lysines or arginines.	Lysine	132-139	Polycomblike	Drosophila melanogaster	0-9
20581860-5	2010	We also found that WDR5, an adaptor protein essential for lysine 4 trimethylation of histone H3 (H3K4me3) by MLL, colocalizes and interacts with MOZ.	Lysine	58-64	WD repeat domain 5	Homo sapiens	19-23
20558618-4	2010	MLL fusion proteins associated with human leukemia contain the menin interaction peptide and frequently recruit H3K79 (histone H3 lysine 79) methylation activity.	Lysine	130-136	menin 1	Homo sapiens	63-68
20832726-2	2010	Methylation of lysine 9 on histone H3 (H3K9) is widely associated with transcriptional silencing, and its disappearance is linked to the activation of several inflammatory genes by NF-kappaB.	Lysine	15-21	nuclear factor kappa B subunit 1	Homo sapiens	181-190
21160808-12	2010	The tumor sequencing results revealed an identical missense mutation in codon 642 of c-kit exon 13 leading to the replacement of lysine by glutamic acid and a silent germ-line mutation in exon 12 of the PDGFRA gene concerning whole blood, normal mucosa and tumors.	Lysine	129-135	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	85-90
20715035-0	2010	Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains.	Lysine	56-62	bromodomain containing 4	Homo sapiens	74-78
20678485-0	2010	A lysine-rich region in Dot1p is crucial for direct interaction with H2B ubiquitylation and high level methylation of H3K79.	Lysine	2-8	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	24-29
20816089-3	2010	Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.	Lysine	250-256	nuclear respiratory factor 1	Mus musculus	57-61
20816089-3	2010	Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.	Lysine	250-256	sirtuin 6	Mus musculus	69-74
20816089-3	2010	Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.	Lysine	250-256	sirtuin 6	Mus musculus	123-128
20798045-4	2010	Loss of function of Ezh2 removes the repressive mark of trimethylated histone H3 at lysine 27 (H3K27me3) in cortical progenitor cells and also prevents its establishment in postmitotic neurons.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	20-24
20678485-2	2010	Dot1p is a histone H3 lysine 79 (H3K79) methyltransferase, but H3K79 trimethylation (H3K79me3) by Dot1p requires histone H2B monoubiquitylation (H2Bub) as a pre-requisite.	Lysine	22-28	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-5
20678485-6	2010	In addition, we demonstrate that a lysine-rich region (aa 101-140) in the first half of DNA binding domain of the Dot1p is critical in interaction with ubiquitin as well as binding to nucleosome core.	Lysine	35-41	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	114-119
20678485-8	2010	Taken together, our results indicate that a direct interaction between the lysine-rich region of Dot1p and the ubiquitin of H2Bub is required for H2Bub-mediated trans-tail regulation.	Lysine	75-81	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	97-102
20378569-6	2010	NOXA had a short half life (approximately 1-2 h) and was ubiquitinated on at least three primary lysine residues, resulting in proteasomal-dependent degradation.	Lysine	97-103	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	0-4
21171714-7	2010	With poly-L-lysine as the underlying layer, biologically significant differences (greater than twofold) in the expression of VWF, VEGFR, VEGFA, endoglin, and ICAM1 were observed among the three glycosaminoglycans.	Lysine	5-18	von Willebrand factor	Homo sapiens	125-128
21171714-7	2010	With poly-L-lysine as the underlying layer, biologically significant differences (greater than twofold) in the expression of VWF, VEGFR, VEGFA, endoglin, and ICAM1 were observed among the three glycosaminoglycans.	Lysine	5-18	vascular endothelial growth factor A	Homo sapiens	137-142
20549206-2	2010	In this study, we sought to determine critical roles of host IFN-alpha and IFN-gamma pathways in the enhanced therapeutic efficacy mediated by peptide vaccines and polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in the murine central nervous system (CNS) GL261 glioma.	Lysine	222-228	interferon gamma	Mus musculus	75-84
20551307-8	2010	Analysis of structural models of CFTR identified that although Lys(584) interacts with residue Leu(581) in human CFTR Glu(584) interacts with Phe(581) in mouse CFTR.	Lysine	63-66	CF transmembrane conductance regulator	Homo sapiens	33-37
20576306-4	2010	RESULTS: Immunoprecipitation experiments using differently mutated human CYP2E1s revealed that conformational anti-CYP2E1 antibodies targeted two epitopes located on the molecule surface in an area between Lys(324)-Glu(346) at J-K"" helices overlapping.	Lysine	206-209	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	73-79
20576306-4	2010	RESULTS: Immunoprecipitation experiments using differently mutated human CYP2E1s revealed that conformational anti-CYP2E1 antibodies targeted two epitopes located on the molecule surface in an area between Lys(324)-Glu(346) at J-K"" helices overlapping.	Lysine	206-209	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	115-121
20521085-4	2010	Further investigation allowed us to determine that Lys 315 of AtHsfA2 is the main SUMOylation site.	Lysine	51-54	heat shock transcription factor A2	Arabidopsis thaliana	62-69
20551307-8	2010	Analysis of structural models of CFTR identified that although Lys(584) interacts with residue Leu(581) in human CFTR Glu(584) interacts with Phe(581) in mouse CFTR.	Lysine	63-66	CF transmembrane conductance regulator	Homo sapiens	113-117
20659425-1	2010	Transglutaminase 2 (TGase2) is a calcium-dependent, cross-linking enzyme that catalyzes iso-peptide bond formation between peptide-bound lysine and glutamine residues.	Lysine	137-143	transglutaminase 2	Homo sapiens	0-18
20650264-1	2010	Utx is a candidate tumor suppressor gene that encodes histone H3 lysine 27 (H3K27) demethylase.	Lysine	65-71	lysine demethylase 6A	Homo sapiens	0-3
20600126-7	2010	Additionally, Met292 (TM7) equivalent to Lys(7.45) (Ballesteros numbering scheme) involved in covalently attaching retinal in rhodopsin is shown to be in close proximity to Trp(9).	Lysine	41-44	rhodopsin	Homo sapiens	126-135
20659425-1	2010	Transglutaminase 2 (TGase2) is a calcium-dependent, cross-linking enzyme that catalyzes iso-peptide bond formation between peptide-bound lysine and glutamine residues.	Lysine	137-143	transglutaminase 2	Homo sapiens	20-26
20703075-4	2010	We previously reported that the highly conserved p53 Arg(R)-174 is substituted by lysine (K) in Spalax, identical to a tumor-associated mutation.	Lysine	82-88	tumor protein p53	Homo sapiens	49-52
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 12	Homo sapiens	0-5
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 12	Homo sapiens	140-145
20631708-3	2010	Here we show that mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations.	Lysine	56-62	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	110-136
20631708-3	2010	Here we show that mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations.	Lysine	56-62	TRITHORAX-RELATED PROTEIN 5	Arabidopsis thaliana	138-143
20472054-9	2010	The actions of IsoKs are consistent with interactions with cytochrome c, a protein rich in lysine residues.	Lysine	91-97	cytochrome c, somatic	Homo sapiens	59-71
20472054-10	2010	Direct reaction of IsoKs with select lysines in cytochrome c was demonstrated using high-resolution mass spectrometry.	Lysine	37-44	cytochrome c, somatic	Homo sapiens	48-60
20614940-1	2010	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	8-14	tumor protein p53	Homo sapiens	124-127
20614940-1	2010	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	69-75	tumor protein p53	Homo sapiens	124-127
20601953-4	2010	EZH2 encodes the catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved histone H3 lysine 27 (H3K27) methyltransferase that influences stem cell renewal by epigenetic repression of genes involved in cell fate decisions.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
20678632-1	2010	The macrocyclic calixarenes and crown ethers have recently been found to form hydrophobic complexes with the cationic protein cytochrome c (Cyt-c), by recognizing lysine residues on the protein surface.	Lysine	163-169	cytochrome c, somatic	Homo sapiens	126-138
20678632-1	2010	The macrocyclic calixarenes and crown ethers have recently been found to form hydrophobic complexes with the cationic protein cytochrome c (Cyt-c), by recognizing lysine residues on the protein surface.	Lysine	163-169	cytochrome c, somatic	Homo sapiens	140-145
20399881-10	2010	These data indicate that cCAT-2A is a low affinity, high velocity transporter for lysine and arginine and is the cCAT-2 isoform responsible for lysine and arginine transport in avian skeletal muscle.	Lysine	82-88	solute carrier family 7 member 2	Gallus gallus	25-31
20399881-10	2010	These data indicate that cCAT-2A is a low affinity, high velocity transporter for lysine and arginine and is the cCAT-2 isoform responsible for lysine and arginine transport in avian skeletal muscle.	Lysine	144-150	solute carrier family 7 member 2	Gallus gallus	25-31
20484053-9	2010	Instead, we found that BACE1 is ubiquitinated at lysine 501 and is mainly monoubiquitinated and Lys-63-linked polyubiquitinated.	Lysine	49-55	beta-secretase 1	Homo sapiens	23-28
20639885-1	2010	The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former"s N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2-p53 association.	Lysine	167-173	tumor protein p53	Homo sapiens	136-139
20639885-1	2010	The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former"s N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2-p53 association.	Lysine	167-173	tumor protein p53	Homo sapiens	136-139
20484053-9	2010	Instead, we found that BACE1 is ubiquitinated at lysine 501 and is mainly monoubiquitinated and Lys-63-linked polyubiquitinated.	Lysine	96-99	beta-secretase 1	Homo sapiens	23-28
20484055-5	2010	Tubulin hyperacetylation on lysine 40 enhances kinesin-1 and JIP-1 recruitment on microtubules and allows JNK phosphorylation and activation.	Lysine	28-34	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	61-66
20484055-5	2010	Tubulin hyperacetylation on lysine 40 enhances kinesin-1 and JIP-1 recruitment on microtubules and allows JNK phosphorylation and activation.	Lysine	28-34	mitogen-activated protein kinase 8	Homo sapiens	106-109
20580719-0	2010	A bacterial ortholog of class II lysyl-tRNA synthetase activates lysine.	Lysine	65-71	lysyl-tRNA synthetase 1	Homo sapiens	33-54
20670893-6	2010	XPA can be acetylated at lysines 63 and 67.	Lysine	25-32	XPA, DNA damage recognition and repair factor	Homo sapiens	0-3
20975703-0	2010	Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin.	Lysine	86-89	calmodulin 1	Homo sapiens	0-10
20975703-0	2010	Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin.	Lysine	86-89	calmodulin 1	Homo sapiens	97-107
20975703-1	2010	Calmodulin (CaM) is a key mediator of calcium-dependent signalling and is subject to regulatory post-translational modifications, including trimethylation of Lys-115.	Lysine	158-161	calmodulin 1	Homo sapiens	0-10
20975703-1	2010	Calmodulin (CaM) is a key mediator of calcium-dependent signalling and is subject to regulatory post-translational modifications, including trimethylation of Lys-115.	Lysine	158-161	calmodulin 1	Homo sapiens	12-15
20489198-5	2010	We have found that a short N-terminal lysine-rich domain conserved in members of the ROS1/DME family mediates strong methylation-independent binding of ROS1 to DNA and is required for efficient activity on 5-meC.G, but not for T.G processing.	Lysine	38-44	demeter-like 1	Arabidopsis thaliana	85-89
20489198-5	2010	We have found that a short N-terminal lysine-rich domain conserved in members of the ROS1/DME family mediates strong methylation-independent binding of ROS1 to DNA and is required for efficient activity on 5-meC.G, but not for T.G processing.	Lysine	38-44	demeter-like 1	Arabidopsis thaliana	152-156
20488183-2	2010	Here, we report that H2AX is constitutively acetylated on lysine 36 (H2AXK36Ac) by the CBP/p300 acetyltransferases.	Lysine	58-64	CREB binding protein	Homo sapiens	87-95
20444690-3	2010	The key structural differences between this new structure and previously published structures are two new hydrogen bonds at positions Ile(37) and Glu(38) in strand C and Lys(66) in strand E, and a hydrophobic pocket around the center of the protein found in Ctid-beta2m.	Lysine	170-173	beta-2-microglobulin	Gallus gallus	263-269
20603076-3	2010	Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a.	Lysine	75-81	RuvB like AAA ATPase 2	Homo sapiens	19-25
20644511-5	2010	In particular, the C-terminal PHD domain, found in a RBP2 oncogenic fusion in human leukemia, binds to trimethylated lysine 4 in histone H3 (H3K4me3).	Lysine	117-123	retinol binding protein 2	Homo sapiens	53-57
20400660-8	2010	The data showed that the adduct was formed via Michael addition with the epsilon-amine of lysine attacking to the beta-carbon of the amide moiety of HKI-272.	Lysine	90-96	hexokinase 1	Homo sapiens	149-152
19784770-6	2010	Immunohistochemical examination of high-grade invasive ductal and lobular breast cancer with our polyclonal antibodies against a peptide (-Met-Ser-Ile-Tyr-Ser-Asp-Lys-Ser-Ile-His-) in the extracellular domain of the NMDAR1 receptor gave specific positive staining for the receptor in all 10 cases examined.	Lysine	163-166	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	216-222
20173184-2	2010	The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains and nuclear localization signal sequences, are present throughout the molecule.	Lysine	67-73	apolipoprotein B	Homo sapiens	45-53
20173184-4	2010	Synthetic peptides representing two apo B100 regions with prominent Arg/Lys clusters were shown to bind DNA.	Lysine	72-75	apolipoprotein B	Homo sapiens	36-44
20484414-5	2010	Purified PCAF acetylated the DNA-binding domain of ERRalpha on four highly-conserved lysines.	Lysine	85-92	estrogen related receptor, alpha	Mus musculus	51-59
20439492-9	2010	The defects in adherens junction protein distribution required integrin signaling as E-cadherin and p120-catenin were restored at cell/cell contacts when cells were plated on poly-l-lysine.	Lysine	175-188	cadherin 1	Homo sapiens	85-95
20463090-2	2010	For example, vernalization (the promotion of flowering by cold temperatures) epigenetically silences FLC expression through repressive histone modifications such as histone H3 lysine-9 dimethylation (H3K9me2) and H3K27me3.	Lysine	176-182	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	101-104
20299342-5	2010	Indeed, SU(VAR)3-7 is sumoylated at lysine K839; this modification is required for localization of SU(VAR)3-7 at pericentric heterochromatin, chromosome 4, and telomeres.	Lysine	36-42	Suppressor of variegation 3-7	Drosophila melanogaster	8-18
20575085-4	2010	The emergence of CBP in chromosomal domains is temporally coincident with the establishments of acetylated lysine 18 (AcH3/K18), lysine 23 (AcH3/K23) and dimethylated arginine 17 (dime-H3/R17) of histone H3 at meiotic stages from germinal vesicle breakdown (GVBD) to metaphase I (MI).	Lysine	107-113	CREB binding protein	Homo sapiens	17-20
20575085-4	2010	The emergence of CBP in chromosomal domains is temporally coincident with the establishments of acetylated lysine 18 (AcH3/K18), lysine 23 (AcH3/K23) and dimethylated arginine 17 (dime-H3/R17) of histone H3 at meiotic stages from germinal vesicle breakdown (GVBD) to metaphase I (MI).	Lysine	129-135	CREB binding protein	Homo sapiens	17-20
20353940-9	2010	Intriguingly, Cdc34 Tyr(210) was required for the transfer of the donor ubiquitin to a receptor lysine on either IkappaBalpha or a ubiquitin in a manner that depended on the neddylated RING sub-complex of the SCF.	Lysine	96-102	NFKB inhibitor alpha	Homo sapiens	113-125
20481588-9	2010	Thus, the methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and we suggest designating the yeast enzyme Ntm1 and the human enzyme NTMT1.	Lysine	88-91	N-terminal Xaa-Pro-Lys N-methyltransferase 1	Homo sapiens	178-183
20507154-11	2010	To better understand these results, we have also used the multilayered polyelectrolyte films as a reservoir for PGA-alpha-MSH by using not only PLL (poly-l-lysine) but also the Dendri Graft poly-l-lysines (DGL(G4)) to be able to adsorb more PGA-alpha-MSH.	Lysine	149-162	proopiomelanocortin	Homo sapiens	116-125
20346425-3	2010	SART1 contains lysines on positions 94, 141, 709 and 742 that are situated in tetrameric sumoylation consensus sites.	Lysine	15-22	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	0-5
20346425-5	2010	We found that Lys(94) and Lys(141) of SART1 were preferentially conjugated to SUMO-2 monomers and multimers in vitro.	Lysine	14-17	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	38-43
20346425-5	2010	We found that Lys(94) and Lys(141) of SART1 were preferentially conjugated to SUMO-2 monomers and multimers in vitro.	Lysine	26-29	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	38-43
20346425-6	2010	In agreement with these results, mutation of Lys(94) and Lys(141), but not Lys(709) and Lys(742), resulted in a reduced sumoylation of SART1 in HeLa cells.	Lysine	45-48	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	135-140
20346425-6	2010	In agreement with these results, mutation of Lys(94) and Lys(141), but not Lys(709) and Lys(742), resulted in a reduced sumoylation of SART1 in HeLa cells.	Lysine	57-60	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	135-140
20346425-6	2010	In agreement with these results, mutation of Lys(94) and Lys(141), but not Lys(709) and Lys(742), resulted in a reduced sumoylation of SART1 in HeLa cells.	Lysine	57-60	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	135-140
20346425-6	2010	In agreement with these results, mutation of Lys(94) and Lys(141), but not Lys(709) and Lys(742), resulted in a reduced sumoylation of SART1 in HeLa cells.	Lysine	57-60	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	135-140
20346425-7	2010	A detailed characterization of the four sumoylation sites of SART1 using full-length recombinant SART1 and a peptide sumoylation approach indicated that positively charged amino acids adjacent to the tetrameric sumoylation consensus site enhance the sumoylation of Lys(94).	Lysine	265-268	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	Homo sapiens	61-66
20403980-4	2010	The results showed that blockade of PKB activity caused significant reduction of CK release and cell death, a benefit that was as potent as ischaemic preconditioning and could be reproduced by blockade of phosphatidylinositol 3-kinase (PI-3K) with wortmannin and LY 294002.	Lysine	263-265	AKT serine/threonine kinase 1	Homo sapiens	36-39
20404349-2	2010	Menin up-regulates certain cyclin-dependent kinase inhibitors through increasing histone H3 lysine 4 (H3K4) methylation and inhibits G(0)/G(1) to S phase transition.	Lysine	92-98	menin 1	Homo sapiens	0-5
20541999-0	2010	Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.	Lysine	73-79	cyclin dependent kinase inhibitor 2A	Homo sapiens	132-137
20541999-1	2010	Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins.	Lysine	139-145	cyclin dependent kinase inhibitor 2B	Homo sapiens	18-23
20541999-1	2010	Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins.	Lysine	139-145	cyclin dependent kinase inhibitor 2A	Homo sapiens	28-33
20551174-3	2010	Binding of Myc to Miz1 is continuously required to repress CKI expression and inhibit accumulation of trimethylated histone H3 at Lys 9 (H3K9triMe), a hallmark of cellular senescence, in T-cell lymphomas.	Lysine	130-133	protein inhibitor of activated STAT 2	Homo sapiens	18-22
20378541-6	2010	Liquid chromatography-electrospray ionization-tandem mass spectrometry of MDA-modified apoA-I revealed that Lys residues at specific sites had been modified.	Lysine	108-111	apolipoprotein A1	Homo sapiens	87-93
20378541-8	2010	Lys residues in the C terminus of apoA-I were targeted for cross-linking in high yield, and this process may hinder the interaction of apoA-I with lipids and ABCA1, two key steps in reverse cholesterol transport.	Lysine	0-3	apolipoprotein A1	Homo sapiens	34-40
20378541-8	2010	Lys residues in the C terminus of apoA-I were targeted for cross-linking in high yield, and this process may hinder the interaction of apoA-I with lipids and ABCA1, two key steps in reverse cholesterol transport.	Lysine	0-3	apolipoprotein A1	Homo sapiens	135-141
20378541-10	2010	Taken together, our observations indicate that MDA damages apoA-I by a pathway that generates lysine adducts at specific sites on the protein.	Lysine	94-100	apolipoprotein A1	Homo sapiens	59-65
20042191-7	2010	The low, relative to the high, Lys:Arg ratio diet resulted in lower postprandial VLDL cholesterol (-24%, P=0.001) and triglycerides (-23%, P=0.001), and small but significant differences in fasting (-3%, P=0.003) and postprandial (-3%, P=0.018) apo AI, and fasting adiponectin concentrations (+7%, P=0.035).	Lysine	31-34	adiponectin, C1Q and collagen domain containing	Homo sapiens	265-276
20382965-8	2010	Notably, Western blot displayed a significant increase in nuclear NF-kappaB p50 and the immunoprecipitation demonstrated a remarkable acetylation of NF-kappaB p50 at lysine residues following HDAC inhibition.	Lysine	166-172	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-162
20642005-12	2004	A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11).	Lysine	52-55	proopiomelanocortin	Homo sapiens	25-34
20388487-6	2010	Furthermore, HDAC2 phosphorylation was required for HDAC2 interaction with transcription factors, co-repressor complex formation, CBP recruitment, acetylation on lysine residues and modulates transrepression activity.	Lysine	162-168	histone deacetylase 2	Homo sapiens	13-18
20388487-6	2010	Furthermore, HDAC2 phosphorylation was required for HDAC2 interaction with transcription factors, co-repressor complex formation, CBP recruitment, acetylation on lysine residues and modulates transrepression activity.	Lysine	162-168	histone deacetylase 2	Homo sapiens	52-57
20395008-2	2010	Among polycomb repressive complexes (PRCs), PRC2 initiates gene silencing by methylating histone H3 lysine 27, and PRC1 maintains gene silencing through mono-ubiquitination of histone H2A lysine 119.	Lysine	188-194	protein regulator of cytokinesis 1	Mus musculus	115-119
20012900-8	2010	Furthermore, PON1 is a multifunctional antioxidant enzyme that can also detoxify the homocysteine metabolite, homocysteine thiolactone (HTL), which can pathologically cause protein damage by homocysteinylation of the lysine residues, thereby leading to atherosclerosis.	Lysine	217-223	paraoxonase 1	Homo sapiens	13-17
20053926-3	2010	Here, we show that the expression of claudin-3 and claudin-4 is repressed in ovarian epithelial cells in association with promoter "bivalent" histone modifications, containing both the activating trimethylated histone H3 lysine 4 (H3K4me3) mark and the repressive mark of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	221-227	claudin 4	Homo sapiens	51-60
20053926-3	2010	Here, we show that the expression of claudin-3 and claudin-4 is repressed in ovarian epithelial cells in association with promoter "bivalent" histone modifications, containing both the activating trimethylated histone H3 lysine 4 (H3K4me3) mark and the repressive mark of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	297-303	claudin 4	Homo sapiens	51-60
20075941-4	2010	The suppressive action of NO on Nanog gene depends on the activation of p53 repressor protein by covalent modifications, such as pSer15, pSer315, pSer392 and acetyl Lys 379.	Lysine	165-168	Nanog homeobox	Mus musculus	32-37
20497763-10	2010	FS is one of the pre-mRNA splicing diseases, in which the occurrence of symptoms is associated with a decrease in the ratio of the lysine-threonine-serine (+/- KTS) isoform of the WT1 protein.	Lysine	131-137	WT1 transcription factor	Homo sapiens	180-183
20392835-7	2010	Furthermore, addition of T(3) triggered alterations in covalent histone modifications at the PLB promoter that are associated with gene silencing, namely a pronounced decrease in both histone H3 acetylation and histone H3 lysine 4 methylation.	Lysine	222-228	phospholamban	Mus musculus	93-96
20435908-4	2010	To gain insights into this question, we have studied the function of heterochromatin protein 1 (HP1), which is a reader of repressive methylation at histone H3 lysine 9, in genome-wide organization of replication.	Lysine	160-166	Suppressor of variegation 205	Drosophila melanogaster	69-94
20435908-4	2010	To gain insights into this question, we have studied the function of heterochromatin protein 1 (HP1), which is a reader of repressive methylation at histone H3 lysine 9, in genome-wide organization of replication.	Lysine	160-166	Suppressor of variegation 205	Drosophila melanogaster	96-99
20110441-0	2010	2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles.	Lysine	48-54	apolipoprotein B	Homo sapiens	71-79
20110441-3	2010	In the present study, high-resolution 2D-NMR spectroscopy has been employed to characterize the surface-exposed lysine residues of the apolipoprotein (apo)B-100 protein in both LDL(-) and LDL(+) subfractions.	Lysine	112-118	apolipoprotein B	Homo sapiens	135-160
20110441-8	2010	Because the abundance of normal Lys is similar in LDL(+) and LDL(-), the intermediate Lys in the apoB-100 molecule of LDL(-) should come from a group of active Lys in LDL(+) particles that have a less basic microenvironment in the LDL(-) particle.	Lysine	86-89	apolipoprotein B	Homo sapiens	97-105
20110441-8	2010	Because the abundance of normal Lys is similar in LDL(+) and LDL(-), the intermediate Lys in the apoB-100 molecule of LDL(-) should come from a group of active Lys in LDL(+) particles that have a less basic microenvironment in the LDL(-) particle.	Lysine	86-89	apolipoprotein B	Homo sapiens	97-105
20368352-7	2010	Mechanistically, ATDC binds p53, and this interaction is potentially fine-tuned by posttranslational acetylation of lysine 116 on ATDC.	Lysine	116-122	tumor protein p53	Homo sapiens	28-31
20215116-5	2010	Two lysines (Lys-503 and Lys-608) of TCERG1 are the major sumoylation sites.	Lysine	4-11	transcription elongation regulator 1	Homo sapiens	37-43
20308061-4	2010	TGF-beta1 binding is predicted to alter LAP conformation, exposing ionic residues (Arg(45), Arg(50), Lys(56), and Arg(58)) on the other side of the alpha-helix, which form the binding site for latent TGF-beta-binding proteins.	Lysine	101-104	transforming growth factor beta 1	Homo sapiens	0-9
20505083-1	2010	Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored.	Lysine	55-61	SET domain, bifurcated 1	Mus musculus	83-89
20505083-1	2010	Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored.	Lysine	55-61	SET domain, bifurcated 1	Mus musculus	122-127
20143318-6	2010	Substrate channeling between the enzymes was observed when NSE with its active regions Leu(11)-Asn(16), Arg(49)-Lys(59), and Gly(155)-Ala(158) covered the Ser(14)-Leu(30) loop of dPGM-B.	Lysine	112-115	enolase 2	Homo sapiens	59-62
20215116-5	2010	Two lysines (Lys-503 and Lys-608) of TCERG1 are the major sumoylation sites.	Lysine	13-16	transcription elongation regulator 1	Homo sapiens	37-43
20215116-5	2010	Two lysines (Lys-503 and Lys-608) of TCERG1 are the major sumoylation sites.	Lysine	25-28	transcription elongation regulator 1	Homo sapiens	37-43
20215116-7	2010	However, mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity.	Lysine	39-45	transcription elongation regulator 1	Homo sapiens	64-70
20307547-7	2010	The signature HKKme2 motif of p53, which defines specificity, is identified through a combination of NMR resonance perturbations, mutagenesis, measurements of binding affinities and docking simulations, and analysis of the crystal structures of 53BP1 bound to p53 peptides containing other dimethyl-lysine marks, p53K370me2 (p53 dimethylated at Lys370) and p53K372me2 (p53 dimethylated at Lys372).	Lysine	299-305	tumor protein p53	Homo sapiens	260-263
20307547-7	2010	The signature HKKme2 motif of p53, which defines specificity, is identified through a combination of NMR resonance perturbations, mutagenesis, measurements of binding affinities and docking simulations, and analysis of the crystal structures of 53BP1 bound to p53 peptides containing other dimethyl-lysine marks, p53K370me2 (p53 dimethylated at Lys370) and p53K372me2 (p53 dimethylated at Lys372).	Lysine	299-305	tumor protein p53	Homo sapiens	260-263
20215116-7	2010	However, mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity.	Lysine	39-45	transcription elongation regulator 1	Homo sapiens	152-158
20307547-7	2010	The signature HKKme2 motif of p53, which defines specificity, is identified through a combination of NMR resonance perturbations, mutagenesis, measurements of binding affinities and docking simulations, and analysis of the crystal structures of 53BP1 bound to p53 peptides containing other dimethyl-lysine marks, p53K370me2 (p53 dimethylated at Lys370) and p53K372me2 (p53 dimethylated at Lys372).	Lysine	299-305	tumor protein p53	Homo sapiens	260-263
20220134-5	2010	Chimeras of RIIIK and RIIIJ tested on the human Kv1.2 channels revealed that Lys-9 from kappaM-RIIIJ is a determinant of its higher potency against hKv1.2.	Lysine	77-80	potassium voltage-gated channel subfamily A member 2	Homo sapiens	48-53
20307547-7	2010	The signature HKKme2 motif of p53, which defines specificity, is identified through a combination of NMR resonance perturbations, mutagenesis, measurements of binding affinities and docking simulations, and analysis of the crystal structures of 53BP1 bound to p53 peptides containing other dimethyl-lysine marks, p53K370me2 (p53 dimethylated at Lys370) and p53K372me2 (p53 dimethylated at Lys372).	Lysine	299-305	tumor protein p53	Homo sapiens	30-33
20220134-5	2010	Chimeras of RIIIK and RIIIJ tested on the human Kv1.2 channels revealed that Lys-9 from kappaM-RIIIJ is a determinant of its higher potency against hKv1.2.	Lysine	77-80	potassium voltage-gated channel subfamily A member 2	Homo sapiens	148-154
20337411-4	2010	Results showed that mutations of Lys 24 and Lys 32 in TSP1 to Ala and of amino acids 24-26 and 32-34 in CRT to Ala significantly weakened the binding of TSP1 and CRT, which is consistent with experimental results.	Lysine	33-36	thrombospondin 1	Homo sapiens	153-157
20470363-10	2010	Additionally we examined co-localization of GLT25D1 with MBL and lysyl hydroxylase 3 (LH3, PLOD3), which is a protein able to catalyze hydroxylation of lysine residues before they can be glycosylated.	Lysine	152-158	collagen beta(1-O)galactosyltransferase 1	Homo sapiens	44-51
20220135-2	2010	We have earlier shown that a proinflammatory signal triggered by one of these peptides, Gln(9)-Lys(25), is mediated by FPR1, a member of the formyl peptide receptor family expressed in human neutrophils.	Lysine	95-98	formyl peptide receptor 1	Homo sapiens	119-123
20337411-4	2010	Results showed that mutations of Lys 24 and Lys 32 in TSP1 to Ala and of amino acids 24-26 and 32-34 in CRT to Ala significantly weakened the binding of TSP1 and CRT, which is consistent with experimental results.	Lysine	33-36	calreticulin	Homo sapiens	162-165
20337411-4	2010	Results showed that mutations of Lys 24 and Lys 32 in TSP1 to Ala and of amino acids 24-26 and 32-34 in CRT to Ala significantly weakened the binding of TSP1 and CRT, which is consistent with experimental results.	Lysine	44-47	thrombospondin 1	Homo sapiens	153-157
20337411-4	2010	Results showed that mutations of Lys 24 and Lys 32 in TSP1 to Ala and of amino acids 24-26 and 32-34 in CRT to Ala significantly weakened the binding of TSP1 and CRT, which is consistent with experimental results.	Lysine	44-47	calreticulin	Homo sapiens	162-165
20216569-2	2010	It has been shown that GH release can be promoted by administration of various amino acids (AAs), such as arginine and lysine, that are present in soy protein.	Lysine	119-125	growth hormone 1	Homo sapiens	23-25
20167237-8	2010	Mutation of both lysine residues is sufficient to abrogate the sumoylation of LRBP.	Lysine	17-23	mevalonate kinase	Rattus norvegicus	78-82
20074640-5	2010	However, we demonstrate that a region consisting of the ERK1/2 docking domain, ERK1/2 phosphorylation sites and either of the two potential ubiquitin-acceptor lysine residues is sufficient to allow poly-ubiquitination and turnover of BIM.	Lysine	159-165	mitogen-activated protein kinase 3	Homo sapiens	56-62
20074640-5	2010	However, we demonstrate that a region consisting of the ERK1/2 docking domain, ERK1/2 phosphorylation sites and either of the two potential ubiquitin-acceptor lysine residues is sufficient to allow poly-ubiquitination and turnover of BIM.	Lysine	159-165	mitogen-activated protein kinase 3	Homo sapiens	79-85
20309721-4	2010	Metnase methylates histone H3 lysine 36 (H3K36), improves the integration of foreign DNA, and enhances DNA double-strand break (DSB) repair by the non-homologous end joining (NHEJ) pathway, potentially dependent on its interaction with DNA Ligase IV.	Lysine	30-36	SET domain and mariner transposase fusion gene	Homo sapiens	0-7
20079745-1	2010	Ca(2+) desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with the deletion of lysine 210 (DeltaK210) in cardiac troponin T (cTnT).	Lysine	169-175	troponin T2, cardiac type	Homo sapiens	195-213
20079745-1	2010	Ca(2+) desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with the deletion of lysine 210 (DeltaK210) in cardiac troponin T (cTnT).	Lysine	169-175	troponin T2, cardiac type	Homo sapiens	215-219
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Lysine	84-90	growth hormone 1	Homo sapiens	108-110
20147392-4	2010	Overexpression of APOBEC3G or lysine-free APOBEC3G stabilized HIV-1 Vif, indicating that APOBEC3G degradation is independent of the degradation of Vif.	Lysine	30-36	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	42-50
20147392-4	2010	Overexpression of APOBEC3G or lysine-free APOBEC3G stabilized HIV-1 Vif, indicating that APOBEC3G degradation is independent of the degradation of Vif.	Lysine	30-36	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	42-50
20147392-5	2010	Furthermore, an in vivo polyubiquitination assay showed that lysine-free APOBEC3G was also polyubiquitinated.	Lysine	61-67	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	73-81
20351197-3	2010	In response to both 17beta-estradiol (E2) and the xenoestrogen diethylstilbestrol, ER signaling via phosphatidylinositol 3-kinase/protein kinase B phosphorylates EZH2 at S21, reducing levels of trimethylation of lysine 27 on histone H3 in hormone-responsive cells.	Lysine	212-218	estrogen receptor 1	Homo sapiens	83-85
20351197-3	2010	In response to both 17beta-estradiol (E2) and the xenoestrogen diethylstilbestrol, ER signaling via phosphatidylinositol 3-kinase/protein kinase B phosphorylates EZH2 at S21, reducing levels of trimethylation of lysine 27 on histone H3 in hormone-responsive cells.	Lysine	212-218	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	162-166
20351197-4	2010	During windows of uterine development that are susceptible to developmental reprogramming, activation of this ER signaling pathway by diethylstilbestrol resulted in phosphorylation of EZH2 and reduced levels of trimethylation of lysine 27 on histone H3 in chromatin of the developing uterus.	Lysine	229-235	estrogen receptor 1	Homo sapiens	110-112
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Lysine	84-90	insulin like growth factor 1	Homo sapiens	111-116
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Lysine	92-95	growth hormone 1	Homo sapiens	108-110
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Lysine	92-95	insulin like growth factor 1	Homo sapiens	111-116
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Lysine	25-31	apolipoprotein E	Mus musculus	44-48
20177150-6	2010	The nuclear export induced by the re-addition of serum or growth factors was prevented by LY 294002 and SH-5, inhibitors of phosphoinositide 3-kinase (PI3K) and Akt/protein kinase B, respectively, suggesting an involvement of the PI3K signaling pathway in the nuclear export of GAPDH.	Lysine	90-92	AKT serine/threonine kinase 1	Homo sapiens	161-164
20177150-6	2010	The nuclear export induced by the re-addition of serum or growth factors was prevented by LY 294002 and SH-5, inhibitors of phosphoinositide 3-kinase (PI3K) and Akt/protein kinase B, respectively, suggesting an involvement of the PI3K signaling pathway in the nuclear export of GAPDH.	Lysine	90-92	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	278-283
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Lysine	25-31	apolipoprotein E	Mus musculus	209-213
20218969-6	2010	Reductive methylation of lysine residues in apoE, which abolished its receptor-binding capability without affecting its ability to interact with HSPGs (heparin sulfate proteoglycans), inhibited the ability of apoE to suppress macrophage responses to LPS, but had no effect on apoE suppression of poly(I-C)-induced macrophage activation.	Lysine	25-31	apolipoprotein E	Mus musculus	209-213
20196770-6	2010	Site-directed mutagenesis of the acceptor lysine residue ablated conjugation of PDE4 with SUMO, suggesting the presence of a single SUMO site in the first subdomain of the conserved PDE4 catalytic unit.	Lysine	42-48	phosphodiesterase 4A	Homo sapiens	80-84
20361782-4	2010	The MD simulations and concomitant binding energy calculations allow identification of preferred binding configurations of the oxidized and reduced Cyt which are established via different lysine residues and, thus, correspond to different orientations and dipole moments.	Lysine	188-194	cytochrome c, somatic	Homo sapiens	148-151
20196770-6	2010	Site-directed mutagenesis of the acceptor lysine residue ablated conjugation of PDE4 with SUMO, suggesting the presence of a single SUMO site in the first subdomain of the conserved PDE4 catalytic unit.	Lysine	42-48	phosphodiesterase 4A	Homo sapiens	182-186
20329706-9	2010	Lysine side chains in EHD1 EH create a region of strong positive surface potential near the NPF binding pocket.	Lysine	0-6	EH domain containing 1	Homo sapiens	22-26
20442859-3	2010	However, using a combination of genetic, biochemical and morphological methodologies, we find that CD4 degradation induced by Vpu is dependent on a key component of the ERAD machinery, the VCP-UFD1L-NPL4 complex, as well as on SCF(beta-TrCP)-dependent ubiquitination of the CD4 cytosolic tail on lysine and serine/threonine residues.	Lysine	296-302	CD4 molecule	Homo sapiens	99-102
20048150-7	2010	Using BMP-6/7 chimeras, we identified lysine 60 as a key residue conferring noggin resistance within the BMP-6 protein.	Lysine	38-44	bone morphogenetic protein 6	Homo sapiens	6-11
20048150-7	2010	Using BMP-6/7 chimeras, we identified lysine 60 as a key residue conferring noggin resistance within the BMP-6 protein.	Lysine	38-44	bone morphogenetic protein 6	Homo sapiens	105-110
20032457-7	2010	Finally, we also show that Abro1, another BRISC subunit, binds directly to Brcc36 and that the Brcc36-Abro1 heterodimer includes a minimal complex with Lys(63)-specific DUB activity.	Lysine	152-155	abraxas 2, BRISC complex subunit	Homo sapiens	27-32
20351264-9	2010	Sequences similar to the Ist2 lysine-rich tail are found in mammalian STIM proteins that reversibly induce the formation of cER under calcium control.	Lysine	30-36	Ist2p	Saccharomyces cerevisiae S288C	25-29
20139424-1	2010	Set2-mediated H3 Lys(36) methylation is a histone modification that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histone deacetylase complex to repress intragenic cryptic transcription.	Lysine	17-20	histone deacetylase 1	Homo sapiens	150-154
20139424-1	2010	Set2-mediated H3 Lys(36) methylation is a histone modification that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histone deacetylase complex to repress intragenic cryptic transcription.	Lysine	17-20	cripto, FRL-1, cryptic family 1	Homo sapiens	206-213
20139424-3	2010	In the current study, we demonstrate that mutation of the lysine 44 residue in histone H4 or the Set2 mutant lacking the histone H4 interaction motif leads to intragenic cryptic transcripts, indicating that the Set2 and histone H4 interaction is important to repress intragenic cryptic transcription.	Lysine	58-64	cripto, FRL-1, cryptic family 1	Homo sapiens	170-177
20183851-0	2010	Peptide architecture: adding an alpha-helix to the PYY lysine side chain provides nanomolar binding and body-weight-lowering effects.	Lysine	55-61	peptide YY	Homo sapiens	51-54
20405012-4	2010	We demonstrate that Gro colocalizes with Rpd3 to the chromatin of a target gene and that this is accompanied by the deacetylation of specific lysines within the N-terminal tails of histones H3 and H4.	Lysine	142-149	groucho	Drosophila melanogaster	20-23
20139424-3	2010	In the current study, we demonstrate that mutation of the lysine 44 residue in histone H4 or the Set2 mutant lacking the histone H4 interaction motif leads to intragenic cryptic transcripts, indicating that the Set2 and histone H4 interaction is important to repress intragenic cryptic transcription.	Lysine	58-64	cripto, FRL-1, cryptic family 1	Homo sapiens	278-285
20032457-7	2010	Finally, we also show that Abro1, another BRISC subunit, binds directly to Brcc36 and that the Brcc36-Abro1 heterodimer includes a minimal complex with Lys(63)-specific DUB activity.	Lysine	152-155	abraxas 2, BRISC complex subunit	Homo sapiens	102-107
20159987-3	2010	The ubiquitin chains assembled on Pex29 in vivo by Ufd2 mainly contain Lys-48 linkages.	Lysine	71-74	ubiquitin-ubiquitin ligase UFD2	Saccharomyces cerevisiae S288C	51-55
20079467-3	2010	A substitution for a lysine residue at position 420 in Gc2 prevents this isoform from being glycosylated at that position.	Lysine	21-27	solute carrier family 25 member 18	Homo sapiens	55-58
20368990-4	2010	Hypoxia induced acetylation of the EPO gene 5" promoter at histone 4 and lysine 23 of histone 3.	Lysine	73-79	erythropoietin	Homo sapiens	35-38
20371724-3	2010	Following treatment with the pan-histone deacetylase inhibitor panobinostat (Novartis Pharmaceuticals), or knockdown of HDAC6 by short hairpin RNA, GRP78 is acetylated in 11 lysine residues, which dissociates GRP78 from PERK.	Lysine	174-180	heat shock protein family A (Hsp70) member 5	Homo sapiens	148-153
20068133-4	2010	RESULTS: Advanced glycation end product (AGE) content of apolipoprotein B100 of LDL from type 2 diabetic patients was higher than from healthy subjects: arginine-derived AGE, 15.8 vs. 5.3 mol% (P &lt; 0.001); and lysine-derived AGE, 2.5 vs. 1.5 mol% (P &lt; 0.05).	Lysine	213-219	apolipoprotein B	Homo sapiens	57-76
20305384-2	2010	Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a (which methylates histone H3 on lysine 9), the relationship between DNA methylation and repressive histone marks has not been fully studied.	Lysine	137-143	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	100-104
20305384-2	2010	Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a (which methylates histone H3 on lysine 9), the relationship between DNA methylation and repressive histone marks has not been fully studied.	Lysine	188-194	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	100-104
20071582-11	2010	While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction.	Lysine	50-53	interferon alpha 1	Homo sapiens	140-143
20127678-5	2010	We also demonstrated that lysine-33 is the dominant, if not the only, SUMO acceptor site of c-Maf.	Lysine	26-32	MAF bZIP transcription factor	Homo sapiens	92-97
20127678-9	2010	We conclude that SUMOylation at lysine-33 is a functionally critical post-translational modification event of c-Maf in Th cells.	Lysine	32-38	MAF bZIP transcription factor	Homo sapiens	110-115
20230194-4	2010	AREAS COVERED IN THIS REVIEW: The histone methyltransferase DOT1L is responsible for methylation of histone H3 at lysine 79 and is involved in the pathobiology of several leukemias, the majority of which are characterized by chromosomal translocations involving the mixed lineage leukemia (MLL) gene.	Lysine	114-120	DOT1 like histone lysine methyltransferase	Homo sapiens	60-65
20236180-5	2010	On the other hand, alanine-scanning mutagenesis identified the N-terminal lysine residues, which may be involved in Holliday junction binding by human SPF45.	Lysine	74-80	RNA binding motif protein 17	Homo sapiens	151-156
20118233-2	2010	Lysine methylation has recently emerged as a key post-translational modification that alters the activity of p53.	Lysine	0-6	tumor protein p53	Homo sapiens	109-112
20431927-1	2010	Methylation of lysine 79 on histone H3 (H3K79) is mediated by a methyltransferase called Dot1-like protein (DOT1L).	Lysine	15-21	DOT1 like histone lysine methyltransferase	Homo sapiens	89-106
20431927-1	2010	Methylation of lysine 79 on histone H3 (H3K79) is mediated by a methyltransferase called Dot1-like protein (DOT1L).	Lysine	15-21	DOT1 like histone lysine methyltransferase	Homo sapiens	108-113
20089860-5	2010	The ubiquitination of Fsp27 is regulated by three lysine residues located in the C-terminal region.	Lysine	50-56	cell death-inducing DFFA-like effector c	Mus musculus	22-27
20089860-6	2010	Substitution of these lysine residues with alanines greatly increased Fsp27 stability and enhanced lipid storage in adipocytes.	Lysine	22-28	cell death-inducing DFFA-like effector c	Mus musculus	70-75
20113438-0	2010	A lysine-63-linked ubiquitin chain-forming conjugase, UBC13, promotes the developmental responses to iron deficiency in Arabidopsis roots.	Lysine	2-8	ubiquitin-conjugating enzyme 13	Arabidopsis thaliana	54-59
20118233-3	2010	Here, we describe a novel lysine methylation site in p53 that is carried out by two homologous histone methyltransferases, G9a and Glp.	Lysine	26-32	tumor protein p53	Homo sapiens	53-56
20118233-4	2010	G9a and Glp specifically methylate p53 at Lys(373), resulting mainly in dimethylation.	Lysine	42-45	tumor protein p53	Homo sapiens	35-38
20118233-5	2010	During DNA damage, the overall level of p53 modified at Lys(373)me2 does not increase, despite the dramatic increase in total p53, indicating that Lys(373)me2 correlates with inactive p53.	Lysine	56-59	tumor protein p53	Homo sapiens	40-43
20080105-3	2010	Here, we report that knockdown of PC4 dramatically alters heterochromatin organization of the genome, accompanied by increased H3K9 (histone H3 at lysine residue 9)/14 acetylation, H3K4 trimethylation and reduction in the level of H3K9 dimethylation.	Lysine	147-153	SUB1 regulator of transcription	Homo sapiens	34-37
20368093-11	2010	The insulin immunohistochemical intensities of islet B cells were significantly stronger in high-dose LMH group than those in model group (P &lt; 0.05).	Lysine	102-105	insulin	Gallus gallus	4-11
20368093-12	2010	In addition, we found that the levels of endogenous insulin were significantly higher and the blood glucose levels were significantly lower in high-dose LMH group than those in model group (P &lt; 0.05).	Lysine	153-156	insulin	Gallus gallus	52-59
20368093-0	2010	Effects of L-lysine monohydrochloride on insulin and blood glucose levels in spinal cord injured rats.	Lysine	11-37	insulin	Gallus gallus	41-48
20175993-4	2010	In this study, we attempted to create a lysine-deficient LIGHT mutant that could be PEGylated site-specifically and would have lower affinity for DcR3.	Lysine	40-46	TNF receptor superfamily member 6b	Homo sapiens	146-150
20106972-7	2010	Indeed, our NMR solution structure of the EHD1 EH-domain in complex with the MICAL-L1 NPFEEEEED peptide indicates that the first two flanking Glu residues lie in a position favorable to form salt bridges with Lys residues within the EH-domain.	Lysine	209-212	EH domain containing 1	Homo sapiens	42-46
19996088-4	2010	Second, we show that Glu-plasminogen bound to carboxy-terminal lysine residues in platelets, fibrin, or extracellular matrix components (fibronectin, laminin) is transformed into plasmin by uPA expressed on monocytes or endothelial cell-derived microparticles but not by tissue-type plasminogen activator (tPA) expressed on neurons.	Lysine	63-69	fibronectin 1	Homo sapiens	137-148
20641976-20	2004	A cyclic peptide, Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys (R832), was identified with phage screening against VCAM-1 (12).	Lysine	34-37	vascular cell adhesion molecule 1	Homo sapiens	106-112
20231316-5	2010	Methylation of histone H3 Lys 4 is dynamically erased and re-established at RBP-J sites upon inhibition and reactivation of Notch signaling.	Lysine	26-29	RIM-binding protein	Drosophila melanogaster	76-79
20231316-5	2010	Methylation of histone H3 Lys 4 is dynamically erased and re-established at RBP-J sites upon inhibition and reactivation of Notch signaling.	Lysine	26-29	Notch	Drosophila melanogaster	124-129
19996088-6	2010	Altogether, these data indicate that cellular uPA but not tPA expressed by distinct cells is specifically involved in the recognition of conformational changes and activation of Glu-plasminogen bound to other biologic surfaces via a lysine-dependent mechanism.	Lysine	233-239	plasminogen activator, urokinase	Homo sapiens	46-49
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	145-151	fibrinogen beta chain	Homo sapiens	46-56
20151114-6	2010	Among lactosylation sites identified only on tryptic peptides, i.e., those reasonably related to intact protein lactosylation, two lysines residues were found for alpha-La, both located in accessible regions of its tertiary structure.	Lysine	131-138	lactalbumin alpha	Homo sapiens	163-171
19969553-7	2010	Furthermore, downregulation of EZH2 by omega-3 PUFAs was accompanied by a decrease in histone 3 lysine 27 trimethylation (H3K27me3) activity of EZH2 and upregulation of E-cadherin and insulin-like growth factor binding protein 3, which are known targets of EZH2.	Lysine	96-102	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	31-35
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	166-172	fibrinogen beta chain	Homo sapiens	46-56
20485928-1	2010	OBJECTIVE: The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries.	Lysine	118-121	lactotransferrin	Homo sapiens	63-79
20485928-5	2010	The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1.	Lysine	13-16	lactotransferrin	Homo sapiens	4-7
20485928-7	2010	CONCLUSIONS: Lactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.	Lysine	43-46	lactotransferrin	Homo sapiens	13-29
20124097-3	2010	Each CD4-CD8 peptide pair was then covalently linked to an N(epsilon)-palmitoyl-lysine residue via a functional base lysine amino group to construct CD4-CD8 lipopeptides.	Lysine	80-86	CD4 molecule	Homo sapiens	5-8
19787286-7	2010	In regard to the mechanism of mucin expression, we have recently reported that MUC1, MUC2, MUC4, and MUC5AC gene expression is regulated by epigenetics (DNA methylation and histone H3 lysine 9 modification) in cancer cell lines, including PDAC cells.	Lysine	184-190	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	85-89
20007604-5	2010	Further, histone H3 lysine 36 methylation that occurs at the active coding sequence stimulates the recruitment of Rad26p.	Lysine	20-26	DNA-dependent ATPase RAD26	Saccharomyces cerevisiae S288C	114-120
19522661-7	2010	Rh-Epo association to the negatively charged head groups via lysine and arginine initiates this transformation.	Lysine	61-67	erythropoietin	Homo sapiens	3-6
19798749-10	2010	We also demonstrated mediation of TDP-43 polyubiquitination by lysine 48 of ubiquitin, indicating a degradation signal in both TDP-43 types.	Lysine	63-69	TAR DNA binding protein	Homo sapiens	34-40
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-80
19966277-3	2010	Here, we report that protein kinase C alpha (PKCalpha) interacts with TDG and phosphorylates amino-terminal serine residues adjacent to lysines acetylated by CREB-binding protein (CBP) and p300 (CBP/p300).	Lysine	136-143	protein kinase C alpha	Homo sapiens	21-43
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	0-6	tumor necrosis factor	Mus musculus	74-101
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	0-6	interleukin 1 beta	Mus musculus	107-124
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	47-53	tumor necrosis factor	Mus musculus	74-101
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	47-53	interleukin 1 beta	Mus musculus	107-124
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	49-52	tumor necrosis factor	Mus musculus	20-28
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	49-52	interleukin 1 beta	Mus musculus	33-41
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	95-98	tumor necrosis factor	Mus musculus	20-28
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	95-98	interleukin 1 beta	Mus musculus	33-41
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	30-33	tumor necrosis factor	Mus musculus	213-221
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	30-33	interleukin 1 beta	Mus musculus	226-234
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	75-78	tumor necrosis factor	Mus musculus	213-221
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	75-78	interleukin 1 beta	Mus musculus	226-234
20123894-1	2010	The Polycomb group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the Polycomb-Repressive Complex 2 (PRC2) including the histone H3 Lys 27 (H3K27) methyltransferase Ezh2.	Lysine	215-218	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	248-252
19880496-6	2010	Using site-directed mutagenesis, we were able to determine that c-Mpl is ubiquitinated on both of its intracellular lysine (K) residues (K(553) and K(573)).	Lysine	116-122	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	64-69
19966277-3	2010	Here, we report that protein kinase C alpha (PKCalpha) interacts with TDG and phosphorylates amino-terminal serine residues adjacent to lysines acetylated by CREB-binding protein (CBP) and p300 (CBP/p300).	Lysine	136-143	protein kinase C alpha	Homo sapiens	45-53
19966277-3	2010	Here, we report that protein kinase C alpha (PKCalpha) interacts with TDG and phosphorylates amino-terminal serine residues adjacent to lysines acetylated by CREB-binding protein (CBP) and p300 (CBP/p300).	Lysine	136-143	CREB binding protein	Homo sapiens	158-178
19966277-3	2010	Here, we report that protein kinase C alpha (PKCalpha) interacts with TDG and phosphorylates amino-terminal serine residues adjacent to lysines acetylated by CREB-binding protein (CBP) and p300 (CBP/p300).	Lysine	136-143	CREB binding protein	Homo sapiens	180-183
20042602-5	2010	HP1-BP74 middle region (BP74Md), composed of 178 amino acid residues (Lys(97)-Lys(274)), formed a chromatosome-like structure with reconstituted mononucleosomes and protected the linker DNA from micrococcal nuclease digestion by approximately 25 bp.	Lysine	70-73	heterochromatin protein 1 binding protein 3	Homo sapiens	0-8
20042602-5	2010	HP1-BP74 middle region (BP74Md), composed of 178 amino acid residues (Lys(97)-Lys(274)), formed a chromatosome-like structure with reconstituted mononucleosomes and protected the linker DNA from micrococcal nuclease digestion by approximately 25 bp.	Lysine	78-81	heterochromatin protein 1 binding protein 3	Homo sapiens	0-8
20188666-3	2010	Here we show that Gcn5, a KAT that functions in transcription, works in parallel with Rtt109, the H3 lysine 56 KAT, to promote RC nucleosome assembly.	Lysine	101-107	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	26-29
20188666-3	2010	Here we show that Gcn5, a KAT that functions in transcription, works in parallel with Rtt109, the H3 lysine 56 KAT, to promote RC nucleosome assembly.	Lysine	101-107	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	111-114
19897580-5	2010	Here we use the exquisite sensitivity of multidimensional protein identification technology and an inducible progenitor cell line to identify a novel differentiation-induced integral membrane plasminogen receptor that exposes a C-terminal lysine on the cell surface, Plg-R(KT) (C9orf46 homolog).	Lysine	239-245	plasminogen receptor with a C-terminal lysine	Homo sapiens	267-276
19897580-5	2010	Here we use the exquisite sensitivity of multidimensional protein identification technology and an inducible progenitor cell line to identify a novel differentiation-induced integral membrane plasminogen receptor that exposes a C-terminal lysine on the cell surface, Plg-R(KT) (C9orf46 homolog).	Lysine	239-245	plasminogen receptor with a C-terminal lysine	Homo sapiens	278-285
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-148
20004207-1	2010	Yeast Saccharomyces cerevisiae MTO2, MTO1, and MSS1 genes encoded highly conserved tRNA modifying enzymes for the biosynthesis of carboxymethylaminomethyl (cmnm)(5)s(2)U(34) in mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln).	Lysine	196-199	tRNA modification protein MTO1	Saccharomyces cerevisiae S288C	37-41
20004207-8	2010	The synthetic enhancement combinations likely resulted from the completely abolished modification at U(34) of tRNA(Lys), tRNA(Glu), and tRNA(Gln), caused by the combination of eliminating the 2-thiouridylation by the mto2 mutation with the absence of the cmnm(5)U(34) by the mto1 or mss1 mutation.	Lysine	115-118	tRNA modification protein MTO1	Saccharomyces cerevisiae S288C	275-279
20181089-3	2010	The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription.	Lysine	170-176	proteasome 26S subunit, ATPase 5	Homo sapiens	15-19
20063892-1	2010	The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity.	Lysine	90-97	CREB binding protein	Homo sapiens	41-44
20181089-6	2010	In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1.	Lysine	29-35	proteasome 26S subunit, ATPase 5	Homo sapiens	185-189
20181089-6	2010	In addition, we show that H3 lysine 27 trimethylation, which is inversely correlated with H3 lysine 4 trimethylation, is significantly elevated in the presence of diminished 19S ATPase Sug1.	Lysine	93-99	proteasome 26S subunit, ATPase 5	Homo sapiens	185-189
20047279-9	2010	From this library, we found an improved clone, scFv#m2-c4 (K(a) = 6.3 x 10(8) M(-1); Lys(H19)Arg, Tyr(H56)Phe, Ser(H84)Pro, Glu(H85)Gly, Gln(L27)Arg, Leu(L36)Met, Ser(L63)Gly, and Ser(L77)Gly).	Lysine	85-88	immunglobulin heavy chain variable region	Homo sapiens	47-51
20008554-3	2010	In this study, we found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation.	Lysine	73-79	caspase recruitment domain family member 11	Homo sapiens	56-62
19851871-3	2010	LRG and Apaf-1 share partial amino acid sequences, compete for binding Cyt c, and are inhibited by modification at lysine 72 in Cyt c.	Lysine	115-121	leucine rich alpha-2-glycoprotein 1	Homo sapiens	0-3
19851871-3	2010	LRG and Apaf-1 share partial amino acid sequences, compete for binding Cyt c, and are inhibited by modification at lysine 72 in Cyt c.	Lysine	115-121	apoptotic peptidase activating factor 1	Homo sapiens	8-14
19851871-3	2010	LRG and Apaf-1 share partial amino acid sequences, compete for binding Cyt c, and are inhibited by modification at lysine 72 in Cyt c.	Lysine	115-121	cytochrome c, somatic	Homo sapiens	128-133
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	241-244	cyclin A2	Homo sapiens	229-237
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cyclin A2	Homo sapiens	229-237
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cyclin A2	Homo sapiens	229-237
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cyclin A2	Homo sapiens	229-237
20074040-5	2010	Interestingly, these four lysine residues in cyclin A also participate in the regulation of cyclin A-Cdk (cyclin-dependent kinase) activity by modulating its interaction with Cdks.	Lysine	26-32	cyclin A2	Homo sapiens	45-53
20074040-5	2010	Interestingly, these four lysine residues in cyclin A also participate in the regulation of cyclin A-Cdk (cyclin-dependent kinase) activity by modulating its interaction with Cdks.	Lysine	26-32	cyclin A2	Homo sapiens	92-100
20100277-0	2010	Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3.	Lysine	23-29	solute carrier organic anion transporter family member 1B3	Homo sapiens	107-149
20100277-4	2010	EXPERIMENTAL APPROACH: Residues Lys28, Lys41 and Arg580 in OATP1B3 were substituted by alanine, arginine, glutamine, glycine or lysine.	Lysine	128-134	solute carrier organic anion transporter family member 1B3	Homo sapiens	59-66
19927155-7	2010	We find that direct binding of p53 to importin-alpha3 depends on the positive charge contributed by lysine residues 319-321 within NLS I.	Lysine	100-106	tumor protein p53	Homo sapiens	31-34
19927155-11	2010	Thus, under normal growth conditions, ubiquitination of Lys 319-321 negatively regulates p53-importin-alpha3 binding, thereby restraining p53 import.	Lysine	56-59	tumor protein p53	Homo sapiens	89-92
19927155-11	2010	Thus, under normal growth conditions, ubiquitination of Lys 319-321 negatively regulates p53-importin-alpha3 binding, thereby restraining p53 import.	Lysine	56-59	tumor protein p53	Homo sapiens	138-141
20093773-4	2010	Here we have demonstrated that c-Myb is recruited to the MLL histone methyl transferase complex by menin, a protein important for MLL-associated leukemic transformation, and that it contributes substantially to MLL-mediated methylation of histone H3 at lysine 4 (H3K4).	Lysine	253-259	menin 1	Homo sapiens	99-104
19917601-3	2010	We find that C-peptide binds to histones and enhances acetylation of lysine residue 16 of histone H4 at the promoter region of genes for ribosomal RNA.	Lysine	69-75	insulin	Homo sapiens	13-22
20648246-6	2010	In addition, a relative increase in trimethylated histone H3 lysine 9 (H3K9M3)-associated DNA starting exactly at the translocation breakpoint and going 2.5 Mb beyond the LRFN5 gene was found.	Lysine	61-67	leucine rich repeat and fibronectin type III domain containing 5	Homo sapiens	171-176
20648246-7	2010	At the LRFN5 promoter, there was a distinct peak of trimethylated histone H3 lysine 27 (H3K27M3)-associated DNA in addition to a diminished trimethylated histone H3 lysine 4 (H3K4M3) level.	Lysine	77-83	leucine rich repeat and fibronectin type III domain containing 5	Homo sapiens	7-12
20648246-7	2010	At the LRFN5 promoter, there was a distinct peak of trimethylated histone H3 lysine 27 (H3K27M3)-associated DNA in addition to a diminished trimethylated histone H3 lysine 4 (H3K4M3) level.	Lysine	165-171	leucine rich repeat and fibronectin type III domain containing 5	Homo sapiens	7-12
19998405-2	2010	TGM2 promotes formation of soluble and insoluble high molecular weight aggregates by catalyzing a covalent linkage between peptide-bound Q residues in polyQ proteins and a peptide-bound Lys residue.	Lysine	186-189	transglutaminase 2	Homo sapiens	0-4
19998405-4	2010	We investigated whether acetylation of Lys-residues by sulfosuccinimidyl acetate (SNA) or aspirin (ASA) would alter the crosslinking activity of TGM2.	Lysine	39-42	transglutaminase 2	Homo sapiens	145-149
19998405-7	2010	Hence, acetylation of Lys-residues may modulate the enzymatic function of TGM2 in vivo and offer a novel approach to treatment of TGM2 mediated disorders.	Lysine	22-25	transglutaminase 2	Homo sapiens	74-78
19998405-7	2010	Hence, acetylation of Lys-residues may modulate the enzymatic function of TGM2 in vivo and offer a novel approach to treatment of TGM2 mediated disorders.	Lysine	22-25	transglutaminase 2	Homo sapiens	130-134
19948738-3	2010	A conserved charged residue (Lys(842)) lies within a putative CaM binding helix in the middle of the AI.	Lysine	29-32	calmodulin 1	Homo sapiens	62-65
19881540-2	2010	In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the DNMT inhibitor, 5-aza-2"-deoxycytidine, induced p15INK4B and E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 (H3K9) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters.	Lysine	267-273	cyclin dependent kinase inhibitor 2B	Homo sapiens	88-96
20043883-0	2010	Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression.	Lysine	26-32	solute carrier family 2 member 5	Homo sapiens	96-102
19881540-2	2010	In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the DNMT inhibitor, 5-aza-2"-deoxycytidine, induced p15INK4B and E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 (H3K9) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters.	Lysine	267-273	cadherin 1	Homo sapiens	101-111
19881540-2	2010	In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the DNMT inhibitor, 5-aza-2"-deoxycytidine, induced p15INK4B and E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 (H3K9) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters.	Lysine	267-273	cyclin dependent kinase inhibitor 2B	Homo sapiens	179-187
19881540-2	2010	In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the DNMT inhibitor, 5-aza-2"-deoxycytidine, induced p15INK4B and E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 (H3K9) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters.	Lysine	267-273	cyclin dependent kinase inhibitor 2B	Homo sapiens	179-187
19880524-2	2010	Here we present evidence that hypoxia causes a rapid decrease in the transcription of the eNOS/NOS3 gene, accompanied by decreased acetylation and lysine 4 (histone H3) methylation of eNOS proximal promoter histones.	Lysine	147-153	nitric oxide synthase 3	Homo sapiens	90-94
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Lysine	221-227	angiotensinogen	Homo sapiens	13-19
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Lysine	221-227	PPARG coactivator 1 alpha	Homo sapiens	45-56
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Lysine	221-227	PPARG coactivator 1 alpha	Homo sapiens	197-208
20045648-5	2010	We have taken advantage of the amino acid difference between the BACE1 and BACE2 at the S2" pocket (BACE1 Pro(70) changed to BACE2 Lys(86)) to build ligands with &gt;500-fold selectivity against BACE2.	Lysine	131-134	beta-secretase 1	Homo sapiens	65-70
19880524-2	2010	Here we present evidence that hypoxia causes a rapid decrease in the transcription of the eNOS/NOS3 gene, accompanied by decreased acetylation and lysine 4 (histone H3) methylation of eNOS proximal promoter histones.	Lysine	147-153	nitric oxide synthase 3	Homo sapiens	95-99
19880524-2	2010	Here we present evidence that hypoxia causes a rapid decrease in the transcription of the eNOS/NOS3 gene, accompanied by decreased acetylation and lysine 4 (histone H3) methylation of eNOS proximal promoter histones.	Lysine	147-153	nitric oxide synthase 3	Homo sapiens	184-188
20064247-3	2010	RESULTS: In this study, we describe that site-specific mutation of p65 at lysines 314 and 315 enhances gene expression of a subset of NF-kappaB target genes including Mmp10 and Mmp13.	Lysine	74-81	matrix metallopeptidase 13	Homo sapiens	177-182
20064247-0	2010	Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression.	Lysine	22-28	nuclear factor kappa B subunit 1	Homo sapiens	55-64
20064247-2	2010	We have earlier reported that p65, a subunit of NF-kappaB, is acetylated in vitro and in vivo at three different lysines (K310, K314 and K315) by the histone acetyltransferase p300.	Lysine	113-120	nuclear factor kappa B subunit 1	Homo sapiens	48-57
20064247-3	2010	RESULTS: In this study, we describe that site-specific mutation of p65 at lysines 314 and 315 enhances gene expression of a subset of NF-kappaB target genes including Mmp10 and Mmp13.	Lysine	74-81	nuclear factor kappa B subunit 1	Homo sapiens	134-143
19875981-3	2010	Sas2 acetylates histone H4 lysine 16 (H4K16), and telomere shortening in tlc1 mutants was accompanied by a selective and Sas2-dependent increase in subtelomeric H4K16 acetylation.	Lysine	27-33	histone acetyltransferase	Saccharomyces cerevisiae S288C	0-4
20593461-2	2010	The Lys(Thz) residue was incorporated into the murine chemokine RANTES to demonstrate its compatibility with Boc/Bzl solid phase peptide synthesis, native chemical ligation, and disulfide bond formation.	Lysine	4-7	chemokine (C-C motif) ligand 5	Mus musculus	64-70
20006587-4	2010	Deletion of a short lysine-rich domain that contains the major SUMO acceptor sites of CBP abrogated its ability to be SUMO modified, and prevented its association with endogenous SUMO-1/PML speckles in vivo.	Lysine	20-26	CREB binding protein	Homo sapiens	86-89
20080798-0	2010	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.	Lysine	60-66	nuclear factor kappa B subunit 1	Homo sapiens	14-23
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	nuclear factor kappa B subunit 1	Homo sapiens	14-23
20080798-8	2010	We conclude that reversible lysine methylation of NF-kappaB is an important element in the complex regulation of this key transcription factor.	Lysine	28-34	nuclear factor kappa B subunit 1	Homo sapiens	50-59
21192791-3	2010	In order to provide more insight into the epigenetic mechanisms leading to the deregulation of autoimmune-related genes in SLE, we asked whether RFX1 is involved in regulating histone 3 lysine 9 (H3K9) tri-methylation at the CD11a and CD70 promoters in SLE CD4(+) T cells.	Lysine	186-192	regulatory factor X1	Homo sapiens	145-149
21209387-5	2010	The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining gene expression.	Lysine	15-21	lysine demethylase 6A	Homo sapiens	56-59
20157260-7	2010	This was accompanied by significant changes in brain fatty acid composition in AbetaPP/PS1 mice that led to a lower membrane peroxidizability index and to reduced protein oxidative damage, as revealed by reduced percentages of the oxidative stress markers: glutamic semialdehyde, aminoadipic semialdehyde, Nepsilon-carboxymethyl-lysine, Nepsilon-carboxyethyl-lysine, and Nepsilon-malondialdehyde-lysine.	Lysine	329-335	histocompatibility 2, class II antigen A, beta 1	Mus musculus	79-86
24363709-1	2010	The non-enzymatic carbamylation of low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and cyanate derived from urea.	Lysine	168-174	apolipoprotein B	Homo sapiens	115-131
20353353-4	2010	We report a Thai family with a compound heterozygosity for Hb Tak [beta147 (+ AC)] and Hb E [beta26(B8)Glu-->Lys] which displayed an asymptomatic erythrocytosis.	Lysine	109-112	cyclin dependent kinase 9	Homo sapiens	62-65
19887647-3	2010	Here we show that ER-alpha proteins with single or double lysine mutations of these motifs (including K303R, a cancer-associated mutant) are resistant to inhibition by BRCA1, even though the mutant ER-alpha proteins retain the ability to bind to BRCA1.	Lysine	58-64	estrogen receptor 1	Homo sapiens	18-26
19864419-7	2010	Endogenous and overexpressed Nedd4 polyubiquitinate Spry2 via Lys(48) on ubiquitin and decrease its stability.	Lysine	62-65	sprouty RTK signaling antagonist 2	Homo sapiens	52-57
19857530-7	2010	Lys 305 of p53 was identified as one of the Ub acceptor sites using this strategy.	Lysine	0-3	tumor protein p53	Homo sapiens	11-14
19861417-7	2009	Persistent DHCR24 overexpression did not alter the phosphorylation status of p53 but resulted in decreased acetylation of p53 at lysine residues 373 and 382 in the nucleus after treatment with hydrogen peroxide.	Lysine	129-135	tumor protein p53	Homo sapiens	122-125
20072656-8	2010	Mass spectrometry performed on immunoprecipitated GRP78 identified lysine-585 as a specific vorinostat-induced acetylation site of GRP78.	Lysine	67-73	heat shock protein family A (Hsp70) member 5	Homo sapiens	50-55
20072656-8	2010	Mass spectrometry performed on immunoprecipitated GRP78 identified lysine-585 as a specific vorinostat-induced acetylation site of GRP78.	Lysine	67-73	heat shock protein family A (Hsp70) member 5	Homo sapiens	131-136
19906698-5	2010	The major SUMO attachment site in Sgs1 is lysine 621, which lies between the Top3 binding domain and the DNA helicase domain.	Lysine	42-48	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	34-38
20499681-2	2010	Hint1 catalyses the process of hydrolysis of the P-N bond in AMP-lysine, AMP-alanine, AMP-NH2.	Lysine	65-71	histidine triad nucleotide binding protein 1	Homo sapiens	0-5
20046871-7	2009	Additionally, we found that Ap2delta is necessary for the recruitment of Ash2l-containing complexes to this promoter and that this recruitment leads to trimethylation of lysine 4 of histone H3 (H3K4me3).	Lysine	170-176	transcription factor AP-2 delta	Homo sapiens	28-36
19828451-5	2009	In contrast, in BD2 the N-terminal linker sequence was found to interact with the binding site for acetylated lysines of the adjacent molecule to form continuous strings in the crystal lattice.	Lysine	110-117	defensin beta 4A	Homo sapiens	16-19
19828451-7	2009	Isothermal titration calorimetry revealed best binding of BD1 to H3 and of BD2 to H4 acetylated lysine sequences, suggesting alternating histone recognition specificities.	Lysine	96-102	defensin beta 4A	Homo sapiens	75-78
19828451-8	2009	Intriguingly, an acetylated lysine motif from cyclin T1 bound similarly well to BD2.	Lysine	28-34	cyclin T1	Homo sapiens	46-55
19828451-8	2009	Intriguingly, an acetylated lysine motif from cyclin T1 bound similarly well to BD2.	Lysine	28-34	defensin beta 4A	Homo sapiens	80-83
20018712-8	2009	The methylation activity of Dnmt3a largely depends on the Dnmt3L"s PHD domain recognizing the histone H3 tail with unmethylated lysine 4.	Lysine	128-134	DNA methyltransferase 3A	Mus musculus	28-34
20064471-5	2009	Moreover, we show that Itch/AIP4 can also stabilize the TGIF protein in response to TNF-alpha by triggering its monoubiquitination at lysine 259, thereby revealing the existence of a functional network that can evolve into a positive feedback loop for ensuring effective execution of the TNF-alpha apoptotic signaling.	Lysine	134-140	itchy E3 ubiquitin protein ligase	Homo sapiens	23-27
20028503-1	2009	BACKGROUND: Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing.	Lysine	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	68-95
20028503-1	2009	BACKGROUND: Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing.	Lysine	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	97-101
20064471-5	2009	Moreover, we show that Itch/AIP4 can also stabilize the TGIF protein in response to TNF-alpha by triggering its monoubiquitination at lysine 259, thereby revealing the existence of a functional network that can evolve into a positive feedback loop for ensuring effective execution of the TNF-alpha apoptotic signaling.	Lysine	134-140	itchy E3 ubiquitin protein ligase	Homo sapiens	28-32
20064471-5	2009	Moreover, we show that Itch/AIP4 can also stabilize the TGIF protein in response to TNF-alpha by triggering its monoubiquitination at lysine 259, thereby revealing the existence of a functional network that can evolve into a positive feedback loop for ensuring effective execution of the TNF-alpha apoptotic signaling.	Lysine	134-140	TGFB induced factor homeobox 1	Homo sapiens	56-60
20064471-5	2009	Moreover, we show that Itch/AIP4 can also stabilize the TGIF protein in response to TNF-alpha by triggering its monoubiquitination at lysine 259, thereby revealing the existence of a functional network that can evolve into a positive feedback loop for ensuring effective execution of the TNF-alpha apoptotic signaling.	Lysine	134-140	tumor necrosis factor	Homo sapiens	84-93
20064471-5	2009	Moreover, we show that Itch/AIP4 can also stabilize the TGIF protein in response to TNF-alpha by triggering its monoubiquitination at lysine 259, thereby revealing the existence of a functional network that can evolve into a positive feedback loop for ensuring effective execution of the TNF-alpha apoptotic signaling.	Lysine	134-140	tumor necrosis factor	Homo sapiens	288-297
19858201-6	2009	Also, Lys-63 tetraubiquitin-conjugated UbcH10 is rapidly deubiquitinated into the monoubiquitinated form, whereas Lys-48 tetraubiquitin targets UbcH10 for degradation.	Lysine	6-9	ubiquitin conjugating enzyme E2 C	Homo sapiens	39-45
19858201-6	2009	Also, Lys-63 tetraubiquitin-conjugated UbcH10 is rapidly deubiquitinated into the monoubiquitinated form, whereas Lys-48 tetraubiquitin targets UbcH10 for degradation.	Lysine	6-9	ubiquitin conjugating enzyme E2 C	Homo sapiens	144-150
19858201-6	2009	Also, Lys-63 tetraubiquitin-conjugated UbcH10 is rapidly deubiquitinated into the monoubiquitinated form, whereas Lys-48 tetraubiquitin targets UbcH10 for degradation.	Lysine	114-117	ubiquitin conjugating enzyme E2 C	Homo sapiens	39-45
19858201-6	2009	Also, Lys-63 tetraubiquitin-conjugated UbcH10 is rapidly deubiquitinated into the monoubiquitinated form, whereas Lys-48 tetraubiquitin targets UbcH10 for degradation.	Lysine	114-117	ubiquitin conjugating enzyme E2 C	Homo sapiens	144-150
19799855-3	2009	A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.	Lysine	116-122	chorionic somatomammotropin hormone 2	Homo sapiens	205-208
19927120-1	2009	TAB2 and TAB3 activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain.	Lysine	120-123	mitogen-activated protein kinase 8	Homo sapiens	27-48
19732783-4	2009	Yeast Sas2p is orthologous to human MYST1, a histone 4 lysine 16 (H4K16) acetyltransferase.	Lysine	55-61	histone acetyltransferase	Saccharomyces cerevisiae S288C	6-11
19799855-3	2009	A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.	Lysine	161-167	chorionic somatomammotropin hormone 2	Homo sapiens	205-208
19822520-6	2009	HDAC2 is not acetylated by p300, although 5 of 6 acetylated lysine residues in HDAC1 are also present in HDAC2.	Lysine	60-66	histone deacetylase 2	Homo sapiens	0-5
19955365-0	2009	Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.	Lysine	46-52	ataxin 7	Homo sapiens	34-42
19822520-6	2009	HDAC2 is not acetylated by p300, although 5 of 6 acetylated lysine residues in HDAC1 are also present in HDAC2.	Lysine	60-66	histone deacetylase 1	Homo sapiens	79-84
19822520-6	2009	HDAC2 is not acetylated by p300, although 5 of 6 acetylated lysine residues in HDAC1 are also present in HDAC2.	Lysine	60-66	histone deacetylase 2	Homo sapiens	105-110
19955365-4	2009	Here, we show that mutating lysine 257 (K257), an amino acid adjacent to the caspase-7 cleavage site of ataxin-7 regulates turnover of the truncation product in a repeat-dependent manner.	Lysine	28-34	ataxin 7	Homo sapiens	104-112
19955385-9	2009	Blocking ER with ICI 182,780 or mGluR1a with LY 367385 prevented ERalpha trafficking to and from the membrane.	Lysine	45-47	estrogen receptor 1	Homo sapiens	65-72
19808676-4	2009	The NSD2 complex purified from human cells and recombinant NSD2 both exhibit specific targeting of histone H3 lysine 36 (H3K36) when provided with nucleosome substrates, but histone H4 lysine 44 is the primary target in the case of octamer substrates, irrespective of the histones being native or recombinant.	Lysine	110-116	nuclear receptor binding SET domain protein 2	Homo sapiens	4-8
19808676-4	2009	The NSD2 complex purified from human cells and recombinant NSD2 both exhibit specific targeting of histone H3 lysine 36 (H3K36) when provided with nucleosome substrates, but histone H4 lysine 44 is the primary target in the case of octamer substrates, irrespective of the histones being native or recombinant.	Lysine	110-116	nuclear receptor binding SET domain protein 2	Homo sapiens	59-63
19808676-4	2009	The NSD2 complex purified from human cells and recombinant NSD2 both exhibit specific targeting of histone H3 lysine 36 (H3K36) when provided with nucleosome substrates, but histone H4 lysine 44 is the primary target in the case of octamer substrates, irrespective of the histones being native or recombinant.	Lysine	185-191	nuclear receptor binding SET domain protein 2	Homo sapiens	4-8
19879767-0	2009	Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.	Lysine	45-48	prepronociceptin	Homo sapiens	53-63
19879767-1	2009	[Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin.	Lysine	9-12	prepronociceptin	Homo sapiens	17-27
19879767-6	2009	These results suggest that Asp206 and Tyr207 are directly involved in the interaction with nociceptin-[Arg(14),Lys(15)].	Lysine	111-114	prepronociceptin	Homo sapiens	91-101
19879767-7	2009	Trp208Ala was found to bind strongly both nociceptin and [Arg(14),Lys(15)]nociceptin, although it elicited no biological activity.	Lysine	66-69	prepronociceptin	Homo sapiens	74-84
19748709-1	2009	A series of oligomeric formylpeptides were synthesized by cross-linking the prototype fMLP using a Lys residue.	Lysine	99-102	formyl peptide receptor 1	Homo sapiens	86-90
19524336-2	2009	The intake of protein as well as the specific amino acids arginine and lysine potently stimulate GH secretion.	Lysine	71-77	growth hormone 1	Homo sapiens	97-99
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Lysine	25-31	small ubiquitin-like modifier 2	Mus musculus	110-116
19850744-6	2009	In the presence of ATRA, lysine 166 (K166) and K171 of RARA were modified at a physiological concentration of SUMO-2, whereas in the absence of ATRA, K399 was the only site that was modified, but at a higher SUMO-2 concentration.	Lysine	25-31	small ubiquitin-like modifier 2	Mus musculus	208-214
19692349-7	2009	Furthermore, myotubes formed in culture from human laminin-alpha2-deficient patient myoblasts produced high levels of activated caspase-3 when grown on poly-L-lysine, but not when grown on a laminin-alpha2-containing substrate or when treated with BIPs.	Lysine	152-165	caspase 3	Homo sapiens	128-137
19934278-1	2009	Polycomb protein EZH2-mediated gene silencing is implicated in breast tumorigenesis through methylation of histone H3 on Lysine 27 (H3K27).	Lysine	121-127	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	17-21
20046085-2	2009	This variant arises from a Lys --&gt; Asn substitution due to a mutation of AAA to AAC or AAT at codon 133 of the beta-globin gene.	Lysine	27-30	serpin family A member 1	Homo sapiens	90-93
19801601-6	2009	In this cell line, the propionylated form of Lys(23) accounted for 7%, a level at least 6-fold higher than in other leukemia cell lines (HL-60 and THP-1) or non-leukemia cell lines (HeLa and IMR-90).	Lysine	45-48	GLI family zinc finger 2	Homo sapiens	147-152
19951915-5	2009	In this paper, we identify Ube2j2 as the primary cellular E2 recruited by the mK3 ligase, and this E2-E3 pair is capable of conjugating Ub on lysine or serine residues of substrates.	Lysine	142-148	ubiquitin-conjugating enzyme E2J 2	Mus musculus	27-33
19951915-5	2009	In this paper, we identify Ube2j2 as the primary cellular E2 recruited by the mK3 ligase, and this E2-E3 pair is capable of conjugating Ub on lysine or serine residues of substrates.	Lysine	142-148	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	78-81
19951915-6	2009	However, surprisingly, Ube2j2-mK3 preferentially promotes ubiquitination of hydroxylated amino acids via ester bonds even when lysine residues are present on wild-type substrates, thus establishing physiological relevance of this novel ubiquitination strategy.	Lysine	127-133	ubiquitin-conjugating enzyme E2J 2	Mus musculus	23-29
19951915-6	2009	However, surprisingly, Ube2j2-mK3 preferentially promotes ubiquitination of hydroxylated amino acids via ester bonds even when lysine residues are present on wild-type substrates, thus establishing physiological relevance of this novel ubiquitination strategy.	Lysine	127-133	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	30-33
19883617-3	2009	Lysine 217 of FXR is the major acetylation site targeted by p300 and SIRT1.	Lysine	0-6	nuclear receptor subfamily 1, group H, member 4	Mus musculus	14-17
19749796-5	2009	Notably, menin binds the PTN locus and enhances Polycomb gene Enhancer of Zeste homolog 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27m3), a negative mark for gene transcription but does not affect histone H3K4 methylation that is usually upregulated by menin in endocrine cells.	Lysine	117-123	menin 1	Homo sapiens	9-14
19749796-5	2009	Notably, menin binds the PTN locus and enhances Polycomb gene Enhancer of Zeste homolog 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27m3), a negative mark for gene transcription but does not affect histone H3K4 methylation that is usually upregulated by menin in endocrine cells.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	62-89
19749796-5	2009	Notably, menin binds the PTN locus and enhances Polycomb gene Enhancer of Zeste homolog 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27m3), a negative mark for gene transcription but does not affect histone H3K4 methylation that is usually upregulated by menin in endocrine cells.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	91-95
19887642-0	2009	HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain.	Lysine	81-87	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	49-57
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	75-78	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	32-35
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	32-35
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	193-196
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	32-35
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	193-196
19844166-3	2009	Importantly, our previous work and the work presented here demonstrate that CDK9 functions to guide a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3.	Lysine	199-205	cyclin dependent kinase 9	Homo sapiens	76-80
19864627-0	2009	Regulation of NF-kappaB activity through lysine monomethylation of p65.	Lysine	41-47	nuclear factor kappa B subunit 1	Homo sapiens	14-23
19864627-3	2009	Here, we report a novel mechanism of NF-kappaB regulation through lysine monomethylation by SET9 methyltransferase.	Lysine	66-72	nuclear factor kappa B subunit 1	Homo sapiens	37-46
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	88-94	tumor necrosis factor	Homo sapiens	13-16
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	109-115	tumor necrosis factor	Homo sapiens	13-16
19622798-6	2009	PARP1 is sumoylated at the single lysine residue K486 within its automodification domain.	Lysine	34-40	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
19884255-3	2009	Loss of histone H3 Lys 9 (H3K9) methyltransferases, particularly SetDB1, had the most profound effects on ES cells.	Lysine	19-22	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	65-71
19841226-10	2009	Lysine was the first limiting amino acid for milk protein synthesis when CM or DDGS were fed, whereas methionine was first limiting when the combination diets were fed.	Lysine	0-6	Weaning weight-maternal milk	Bos taurus	45-49
20024960-6	2009	DEB increased the acetylation of p53 at lys-382, dramatically reduced complex formation between p53 and its regulator protein mdm2 and induced the phosphorylation of p53 at serines 15, 20, 37, 46, and 392 in human lymphoblasts.	Lysine	40-43	tumor protein p53	Homo sapiens	33-36
19740772-6	2009	Results of chromatin immunoprecipitation experiments indicate that in dAda2b mutants, the lysine 9-acetylated histone H3 levels are decreased both at dSAGA up- and down-regulated genes.	Lysine	90-96	transcriptional Adaptor 2b	Drosophila melanogaster	70-76
19787243-0	2009	Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells.	Lysine	20-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	106-109
19642109-3	2009	The vertical dimension and the bearing volume of the DNA binding domain (DBD) of p53, anchored to functionalized gold substrate through exposed lysine residues, alone and after deposing AZ, have been measured by TM-AFM.	Lysine	144-150	tumor protein p53	Homo sapiens	81-84
19740772-0	2009	The loss of histone H3 lysine 9 acetylation due to dSAGA-specific dAda2b mutation influences the expression of only a small subset of genes.	Lysine	23-29	transcriptional Adaptor 2b	Drosophila melanogaster	66-72
19778927-1	2009	Dot1 is a conserved histone methyltransferase that methylates histone H3 on lysine 79.	Lysine	76-82	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
19740772-1	2009	In Drosophila, the dADA2b-containing dSAGA complex is involved in histone H3 lysine 9 and 14 acetylation.	Lysine	77-83	transcriptional Adaptor 2b	Drosophila melanogaster	19-25
19740772-2	2009	Curiously, although the lysine 9- and 14-acetylated histone H3 levels are drastically reduced in dAda2b mutants, these animals survive until a late developmental stage.	Lysine	24-30	transcriptional Adaptor 2b	Drosophila melanogaster	97-103
19755537-6	2009	clf-59 mutants have elevated levels of trimethylation on lysine 27 of histone H3 (H3K27me3) at FLC.	Lysine	57-63	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	95-98
19706600-3	2009	Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation.	Lysine	98-104	tumor necrosis factor	Mus musculus	49-57
20099524-1	2009	Eight short peptides containing L-lysine and epsilon-aminocaproic acid were obtained and their effect on the amidolytic activities of plasmin, thrombin and trypsin was examined.	Lysine	32-40	coagulation factor II, thrombin	Homo sapiens	143-151
19706600-3	2009	Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation.	Lysine	98-104	tumor necrosis factor	Mus musculus	207-215
19706600-0	2009	Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation.	Lysine	75-81	tumor necrosis factor	Mus musculus	0-27
19706600-3	2009	Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation.	Lysine	98-104	tumor necrosis factor	Mus musculus	20-47
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Lysine	64-70	tumor necrosis factor	Mus musculus	102-110
19737936-6	2009	The JNK substrate Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated lysines 140 and 143, and promoted MKK4 degradation.	Lysine	115-122	mitogen-activated protein kinase 8	Homo sapiens	4-7
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Lysine	64-70	tumor necrosis factor	Mus musculus	152-160
19737936-6	2009	The JNK substrate Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated lysines 140 and 143, and promoted MKK4 degradation.	Lysine	115-122	itchy E3 ubiquitin protein ligase	Homo sapiens	18-22
19843460-5	2009	Titin exon microarray analysis showed increased expression of a large group of exons in neonatal muscle, when compared to adult muscle transcripts, with the majority of upregulated exons coding for the elastic proline-glutamate-valine-lysine (PEVK) region of titin.	Lysine	235-241	titin	Mus musculus	0-5
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	tumor protein p53	Homo sapiens	110-113
19523458-1	2009	C-terminal acylation of Lys(37) with myristic (MYR; tetradecanoic acid), palmitic (PAL; hexadecanoic acid) and stearic (octadecanoic acid) fatty acids with or without N-terminal acetylation was employed to develop long-acting analogues of the glucoregulatory hormone, glucose-dependent insulinotropic polypeptide (GIP).	Lysine	24-27	gastric inhibitory polypeptide	Mus musculus	268-312
19523458-1	2009	C-terminal acylation of Lys(37) with myristic (MYR; tetradecanoic acid), palmitic (PAL; hexadecanoic acid) and stearic (octadecanoic acid) fatty acids with or without N-terminal acetylation was employed to develop long-acting analogues of the glucoregulatory hormone, glucose-dependent insulinotropic polypeptide (GIP).	Lysine	24-27	gastric inhibitory polypeptide	Mus musculus	314-317
19523458-4	2009	GIP(Lys(37)MYR) and N-AcGIP(Lys(37)MYR) elicited protracted glucose-lowering effects when administered 24h prior to an intraperitoneal glucose load.	Lysine	4-7	gastric inhibitory polypeptide	Mus musculus	0-3
19523458-5	2009	Daily administration of GIP(Lys(37)MYR) and N-AcGIP(Lys(37)MYR) to ob/ob mice for 24 days decreased glucose and significantly improved plasma insulin, glucose tolerance and beta-cell glucose responsiveness.	Lysine	28-31	gastric inhibitory polypeptide	Mus musculus	24-27
20641841-0	2004	(111)In-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-Phe(4-NO2)-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2 Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1).	Lysine	94-97	growth hormone 1	Homo sapiens	170-182
20641841-0	2004	(111)In-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-Phe(4-NO2)-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2 Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1).	Lysine	94-97	insulin	Homo sapiens	194-201
19523989-2	2009	Preproinsulin for PIns was cloned and expressed using a bacterial expression system at a high level (72.1%) as fusion protein carrying a modified thioredoxin N-terminal region (1-21) linked to N-terminus of proinsulin by a lysine residue.	Lysine	223-229	insulin	Homo sapiens	0-13
19826484-2	2009	Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.	Lysine	80-86	Tec1p	Saccharomyces cerevisiae S288C	42-46
19826488-5	2009	hARD1, which is known to have the activity of protein lysine epsilon-acetylation, bound to and acetylated MLCK activated by Ca(2+) signaling, and by so doing deactivated MLCK, which led to a reduction in the phosphorylation of MLC.	Lysine	54-60	modulator of VRAC current 1	Homo sapiens	106-109
19825182-2	2009	This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH).	Lysine	123-129	deoxyhypusine synthase	Homo sapiens	151-173
19666177-0	2009	Unique clinicopathological features and PrP profiles in the first autopsied case of dura mater graft-associated Creutzfeldt-Jakob disease with codon 219 lysine allele observed in Japanese population.	Lysine	153-159	prion protein	Homo sapiens	40-43
19666177-1	2009	Polymorphism at codon 219 lysine in prion protein (PrP) is considered to affect the clinicopathological features of prion diseases including Creutzfeldt-Jakob disease (CJD) and to have an inhibiting effect on the pathogenesis of these diseases.	Lysine	26-32	prion protein	Homo sapiens	51-54
19666177-2	2009	We describe the first autopsied case of dura mater graft-associated CJD (dCJD) with heterozygosity of lysine at codon 219 in PrP observed in a Japanese subject.	Lysine	102-108	prion protein	Homo sapiens	125-128
19666177-5	2009	Thus, these findings can be unique to dCJD with codon 219 lysine allele, and this allele may influence the clinicopathological features and PrP profiles in dCJD.	Lysine	58-64	prion protein	Homo sapiens	140-143
19825828-4	2009	Through the use of the Ubc13-Uev1A E2 complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling.	Lysine	65-71	TNF receptor-associated factor 6	Mus musculus	100-150
19825828-4	2009	Through the use of the Ubc13-Uev1A E2 complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling.	Lysine	65-71	TNF receptor-associated factor 6	Mus musculus	152-157
19825828-6	2009	We also showed that the lysine-124 residue of TRAF6 was critical for efficient Act1-mediated ubiquitination of TRAF6 and for the ability of TRAF6 to mediate IL-17-induced activation of nuclear factor kappaB.	Lysine	24-30	TNF receptor-associated factor 6	Mus musculus	46-51
19825828-6	2009	We also showed that the lysine-124 residue of TRAF6 was critical for efficient Act1-mediated ubiquitination of TRAF6 and for the ability of TRAF6 to mediate IL-17-induced activation of nuclear factor kappaB.	Lysine	24-30	TNF receptor-associated factor 6	Mus musculus	111-116
19825828-6	2009	We also showed that the lysine-124 residue of TRAF6 was critical for efficient Act1-mediated ubiquitination of TRAF6 and for the ability of TRAF6 to mediate IL-17-induced activation of nuclear factor kappaB.	Lysine	24-30	TNF receptor-associated factor 6	Mus musculus	111-116
19557426-3	2009	The Dido gene codes for three proteins that recognize trimethylated histone H3 lysine 4 through their amino-terminal plant homeodomain domain.	Lysine	79-85	death inducer-obliterator 1	Mus musculus	4-8
19809202-7	2009	We found that Gap1 was removed from the plasma membrane in the presence of ethanol in a Rsp5-dependent manner, and that the disappearance of Gap1 required Ubc4 and involved the lysine residues of ubiquitin.	Lysine	177-183	amino acid permease GAP1	Saccharomyces cerevisiae S288C	141-145
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	124-127	casein beta	Bos taurus	11-23
19662020-5	2009	Ternary drug-receptor interactions, which occur between the hydroxyl group of olmesartan and Tyr(113) and between the carboxyl group of olmesartan and Lys(199) and His(256), were essential for the potent inverse agonist action olmesartan exerts against stretch-induced ERK activation and the constitutive activity of the AT(1)-N111G mutant receptor.	Lysine	151-154	mitogen-activated protein kinase 1	Homo sapiens	269-272
19562690-6	2009	p38 MAPK-NF-kappaB signaling pathway and histone H3 lysine (K) nine modifications are involved in TXNIP-induced inflammation.	Lysine	52-58	thioredoxin interacting protein	Homo sapiens	98-103
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	50-53	casein beta	Bos taurus	11-23
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	124-127	casein beta	Bos taurus	85-97
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	50-53	casein beta	Bos taurus	85-97
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	124-127	casein beta	Bos taurus	11-23
19762820-6	2009	Similarly, milk protein responses to supplemental Lys decreased from 5.0 to 3.2 g of milk protein per gram of metabolizable Lys intake as Lys intake varied from 80 to 203 g per cow per day.	Lysine	124-127	casein beta	Bos taurus	85-97
19762820-7	2009	Assuming Met and Lys concentrations of 2.76 and 7.63 g/100 g of milk protein, respectively, the implied marginal efficiencies of metabolizable AA use for MPY decreased from 44 to 12% for Met and from 39 to 25% for Lys over the range of metabolizable AA intakes.	Lysine	17-20	casein beta	Bos taurus	64-76
19762820-7	2009	Assuming Met and Lys concentrations of 2.76 and 7.63 g/100 g of milk protein, respectively, the implied marginal efficiencies of metabolizable AA use for MPY decreased from 44 to 12% for Met and from 39 to 25% for Lys over the range of metabolizable AA intakes.	Lysine	214-217	casein beta	Bos taurus	64-76
19851738-6	2009	A transient expression of HsdM-EGFP in COS-1 cells exhibited exclusively a nuclear localization of the fusion proteins, whereas the fusion proteins of HsdM with substitutions in residues lysine to alanine in the NLS sequences, (7)AAAKAAA(13), were localized in the cytoplasm.	Lysine	187-193	Type I restriction modification system, methylase protein	Klebsiella pneumoniae	151-155
19567366-7	2009	Thus, analysis of fibroblast growth factor-2 bound to heparin and incubated with N-hydroxysuccinimide acetate showed that lysines involved in the sugar binding are protected against chemical modification.	Lysine	122-129	fibroblast growth factor 2	Homo sapiens	18-44
19798443-3	2009	According to the model, histone methyltransferase enzymes (HMTases) methylate the histone H3 at lysine 9 (H3K9me), creating selective binding sites for itself and the chromodomain of HP1a.	Lysine	96-102	Suppressor of variegation 205	Drosophila melanogaster	183-187
19667075-7	2009	A role of Cdk7 in regulating elongation is further suggested by enhanced histone H4 acetylation and diminished histone H4 trimethylation on lysine 36-two marks of elongation-within genes when the kinase was inhibited.	Lysine	140-146	cyclin dependent kinase 7	Homo sapiens	10-14
19581932-3	2009	Importantly, treatment with the specific SUV39H1 inhibitor, chaetocin, repressed histone H3 lysine 9 trimethylation at the p21 gene promoter, stimulated p21 gene expression and induced cell cycle arrest.	Lysine	92-98	SUV39H1 histone lysine methyltransferase	Homo sapiens	41-48
19855050-0	2009	ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.	Lysine	62-68	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	123-140
19855050-2	2009	FLC activation by FRI involves methylation of Lys 4 of histone H3 (H3K4) at FLC chromatin.	Lysine	46-49	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	0-3
19855050-2	2009	FLC activation by FRI involves methylation of Lys 4 of histone H3 (H3K4) at FLC chromatin.	Lysine	46-49	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	76-79
20137623-10	2009	Bioinformatics analysis found that C5orf21 gene was located in chromosome 5q15 and C5orf21 protein contained Arb2 domain associated with histone H3 lysine 9 methylation.	Lysine	148-154	arrestin beta 2	Homo sapiens	109-113
19581932-3	2009	Importantly, treatment with the specific SUV39H1 inhibitor, chaetocin, repressed histone H3 lysine 9 trimethylation at the p21 gene promoter, stimulated p21 gene expression and induced cell cycle arrest.	Lysine	92-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	123-126
19782019-2	2009	(2009) described distinct distributions and regulation of Dot1-dependent methylation states at lysine 79 on histone H3 and showed cell-cycle regulation of K79 dimethylation on genes expressed during the G1/S phase.	Lysine	95-101	DOT1 like histone lysine methyltransferase	Homo sapiens	58-62
19660591-0	2009	Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence.	Lysine	12-18	hemagglutinin-neuraminidase	Mumps orthorubulavirus	36-63
19660591-5	2009	Some studies have specifically implicated variants containing a lysine residue at amino acid position 335 in the hemagglutinin-neuraminidase (HN) protein with neurotoxicity, whereas a glutamic acid residue at this position was associated with attenuation.	Lysine	64-70	hemagglutinin-neuraminidase	Mumps orthorubulavirus	113-140
19531064-0	2009	Role of the RING-CH domain of viral ligase mK3 in ubiquitination of non-lysine and lysine MHC I residues.	Lysine	72-78	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	43-46
19625249-4	2009	Conserved lysine residue 183 located in the activation domain of PGC-1alpha was identified as the major site of SUMO conjugation.	Lysine	10-16	PPARG coactivator 1 alpha	Homo sapiens	65-75
19564335-6	2009	Using chromatin immunoprecipitation we show that the eIF2alpha-dependent translationally regulated gene ATF4 binds directly to the CA9 promoter and is associated with loss of the transcriptional repressive histone 3 lysine 27 tri-methylation mark.	Lysine	216-222	activating transcription factor 4	Mus musculus	104-108
18646203-4	2009	The result is a lysine-derivatized surface in which the epsilon-amino groups of the lysine are free to participate in binding plasminogen and tissue plasminogen activator (t-PA).	Lysine	16-22	plasminogen activator, tissue type	Homo sapiens	142-176
18646203-4	2009	The result is a lysine-derivatized surface in which the epsilon-amino groups of the lysine are free to participate in binding plasminogen and tissue plasminogen activator (t-PA).	Lysine	84-90	plasminogen activator, tissue type	Homo sapiens	142-176
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	multiple endocrine neoplasia 1	Mus musculus	0-5
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	multiple endocrine neoplasia 1	Mus musculus	26-30
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	multiple endocrine neoplasia 1	Mus musculus	32-67
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	lysine (K)-specific methyltransferase 2A	Mus musculus	154-158
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	lysine (K)-specific methyltransferase 2A	Mus musculus	160-184
19596783-1	2009	Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 of histone H3 (H3K4).	Lysine	273-279	lysine (K)-specific methyltransferase 2B	Mus musculus	186-190
19729656-3	2009	S1P specifically bound to the histone deacetylases HDAC1 and HDAC2 and inhibited their enzymatic activity, preventing the removal of acetyl groups from lysine residues within histone tails.	Lysine	152-158	histone deacetylase 1	Homo sapiens	51-56
19531064-0	2009	Role of the RING-CH domain of viral ligase mK3 in ubiquitination of non-lysine and lysine MHC I residues.	Lysine	83-89	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	43-46
19531064-7	2009	We found that although a conserved W present in all viral RING-CH domains is critical for mK3 function, sequences outside the RING-CH domain determine whether and which non-lysine substrate residues can be ubiquitinated by mK3.	Lysine	173-179	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	223-226
19589778-6	2009	Kinetic analyses revealed differential contributions toward the functional activity of Hgt1p by these residues and identified Asn-124 in transmembrane domain 1 (TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop region 537-568 containing the highly conserved proline-rich motif to be essential for the transport activity of the protein.	Lysine	228-231	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	87-92
19589784-2	2009	Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair.	Lysine	70-73	FA complementation group I	Homo sapiens	35-40
19589784-4	2009	We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro.	Lysine	55-58	FA complementation group I	Homo sapiens	25-30
19589784-4	2009	We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro.	Lysine	55-58	ubiquitin conjugating enzyme E2 T	Homo sapiens	70-75
19580779-0	2009	Multiple roles of the active site lysine of Dopa decarboxylase.	Lysine	34-40	dopa decarboxylase	Homo sapiens	44-62
19713527-3	2009	We found that the protein kinase Akt undergoes lysine-63 chain ubiquitination, which is important for Akt membrane localization and phosphorylation.	Lysine	47-53	AKT serine/threonine kinase 1	Homo sapiens	33-36
19713527-3	2009	We found that the protein kinase Akt undergoes lysine-63 chain ubiquitination, which is important for Akt membrane localization and phosphorylation.	Lysine	47-53	AKT serine/threonine kinase 1	Homo sapiens	102-105
19520086-11	2009	The rotation of this glutamate into salt-bridging distance with a lysine moiety correlates with an enhanced enthalpic contribution to binding for these highly potent thrombin binders.	Lysine	66-72	coagulation factor II, thrombin	Homo sapiens	166-174
19409431-3	2009	Tailor-designed l-lysine peptides (K4 and K20) were employed to modify the surface charge of PLGA foams using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide cross linkers and the effects of charge modification of PLGA were examined in three main aspects: DNA adsorption, DNA release properties and DNA transfection.	Lysine	18-24	keratin 20	Homo sapiens	42-45
19506301-2	2009	In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death.	Lysine	129-132	poly(ADP-ribose) polymerase 1	Homo sapiens	115-121
19555118-7	2009	Based on similarities with visual arrestin, Lys-10 and Lys-11 likely function as phospho sensors in arrestin2 to initially discriminate the phosphorylation status of target receptors.	Lysine	44-47	arrestin beta 1	Homo sapiens	100-109
19555118-7	2009	Based on similarities with visual arrestin, Lys-10 and Lys-11 likely function as phospho sensors in arrestin2 to initially discriminate the phosphorylation status of target receptors.	Lysine	55-58	arrestin beta 1	Homo sapiens	100-109
19555118-8	2009	Analysis of the arrestin2 structure reveals that Arg-7, Lys-10, and Lys-11 are in close proximity to Glu-389 and Asp-390, suggesting that these residues may form intramolecular interactions.	Lysine	56-59	arrestin beta 1	Homo sapiens	16-25
19397901-14	2009	The data presented herein indicate that GA causes post-translational modification of lysine and arginine residues, which are central to many events involving fibrinogen to fibrin conversion, as well as to fibrinolysis.	Lysine	85-91	fibrinogen beta chain	Homo sapiens	158-168
19509293-3	2009	PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression.	Lysine	87-93	protein arginine methyltransferase 6	Homo sapiens	0-5
19555118-8	2009	Analysis of the arrestin2 structure reveals that Arg-7, Lys-10, and Lys-11 are in close proximity to Glu-389 and Asp-390, suggesting that these residues may form intramolecular interactions.	Lysine	68-71	arrestin beta 1	Homo sapiens	16-25
19553295-3	2009	OBJECTIVES: The objectives were to determine the effect of lysine ingestion on insulin and glucagon concentrations and whether the effect is moderated by glucose ingestion.	Lysine	59-65	insulin	Homo sapiens	79-86
19553295-12	2009	CONCLUSIONS: Lysine ingestion results in a small decrease in serum glucose and an increase in glucagon and insulin concentrations.	Lysine	13-19	insulin	Homo sapiens	107-114
19553295-10	2009	Lysine alone increased the insulin area response modestly; the insulin increase when lysine was ingested with glucose was similar to that when only glucose was ingested.	Lysine	0-6	insulin	Homo sapiens	27-34
19368695-2	2009	Repression of FLC occurs in response to prolonged cold exposure (vernalization) and is associated with an enrichment of the repressive histone modification trimethylated H3 lysine 27 (H3K27me3) and a depletion of the active histone modification H3K4me3 at FLC chromatin.	Lysine	173-179	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	14-17
19577933-0	2009	Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.	Lysine	92-95	prepronociceptin	Homo sapiens	101-111
19578370-2	2009	Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that the NAD(+)-dependent deacetylase SIRT1 (sirtuin-1) removes the acetyl group from K633.	Lysine	130-136	bromodomain adjacent to zinc finger domain 2A	Homo sapiens	83-87
19473976-1	2009	Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413).	Lysine	69-72	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	29-33
19820304-4	2009	This complex catalyses the tri-methylation of histone H3 lysine 27 (H3K27me3), a repressive chromatin mark that increases at the FLC locus as a result of vernalization.	Lysine	57-63	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	129-132
19638198-1	2009	BACKGROUND: Methylation of lysine 79 on histone H3 by Dot1 is required for maintenance of heterochromatin structure in yeast and humans.	Lysine	27-33	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	54-58
19473976-1	2009	Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413).	Lysine	61-68	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	29-33
19500310-1	2009	Human leukocyte antigen (HLA)-DRB1*1611 has one nucleotide change at codon 14 (GAG--&gt;AAG) from DRB1*160201, resulting in a coding change from Glu to Lys.	Lysine	152-155	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-34
19491097-0	2009	GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.	Lysine	85-91	PPARG coactivator 1 beta	Homo sapiens	67-76
19473976-1	2009	Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413).	Lysine	78-81	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	29-33
19491097-4	2009	Here, we show that PGC-1beta is acetylated on at least 10 lysine residues distributed along the length of the protein by the acetyl transferase general control of amino-acid synthesis (GCN5) and that this acetylation reaction is reversed by the deacetylase sirtuin 1 (SIRT1).	Lysine	58-64	PPARG coactivator 1 beta	Homo sapiens	19-28
19473976-1	2009	Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413).	Lysine	78-81	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	29-33
19473976-1	2009	Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys(38), Lys(45), Lys(282), and Lys(413).	Lysine	78-81	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	29-33
19494119-3	2009	We and others identified acetylation of the p53 DNA binding domain at lysine 120 as a critical event in apoptosis induction.	Lysine	70-76	tumor protein p53	Homo sapiens	44-47
19473976-7	2009	Additional mutagenesis revealed that DIDS cross-links MCT1 to its ancillary protein embigin using either Lys(38) or Lys(290) of MCT1 and Lys(160) or Lys(164) of embigin.	Lysine	105-108	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	54-58
19494119-4	2009	Although initial studies showed that Lys-120 acetylation plays a role in p53 function in the nucleus, we report here a role for Lys-120 acetylation in transcription-independent apoptosis.	Lysine	37-40	tumor protein p53	Homo sapiens	73-76
19494119-5	2009	We demonstrate that the Lys-120-acetylated isoform of p53 is enriched at mitochondria.	Lysine	24-27	tumor protein p53	Homo sapiens	54-57
19473976-7	2009	Additional mutagenesis revealed that DIDS cross-links MCT1 to its ancillary protein embigin using either Lys(38) or Lys(290) of MCT1 and Lys(160) or Lys(164) of embigin.	Lysine	116-119	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	54-58
19494119-9	2009	These data support a model whereby Lys-120 acetylation contributes to both the transcription-dependent and -independent apoptotic pathways induced by p53.	Lysine	35-38	tumor protein p53	Homo sapiens	150-153
19473976-7	2009	Additional mutagenesis revealed that DIDS cross-links MCT1 to its ancillary protein embigin using either Lys(38) or Lys(290) of MCT1 and Lys(160) or Lys(164) of embigin.	Lysine	116-119	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	54-58
19473976-7	2009	Additional mutagenesis revealed that DIDS cross-links MCT1 to its ancillary protein embigin using either Lys(38) or Lys(290) of MCT1 and Lys(160) or Lys(164) of embigin.	Lysine	116-119	malignant T-cell amplified sequence 1 S homeolog	Xenopus laevis	54-58
19473974-10	2009	Based on the location of these sites and available structural information, we propose a refined model of C1 assembly where the CUB(1)-EGF-CUB(2) interaction domains of C1r and C1s are entirely clustered inside C1q and interact through six binding sites with reactive lysines of the C1q stems.	Lysine	267-274	complement C1r	Homo sapiens	168-171
19483727-2	2009	Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112.	Lysine	126-133	cyclin A2	Homo sapiens	73-81
19483727-9	2009	All these results indicate that cyclin A acetylation at specific lysines is crucial for cyclin A stability and also has a function in the regulation of cycA-cdk activity.	Lysine	65-72	cyclin A2	Homo sapiens	32-40
19483727-9	2009	All these results indicate that cyclin A acetylation at specific lysines is crucial for cyclin A stability and also has a function in the regulation of cycA-cdk activity.	Lysine	65-72	cyclin A2	Homo sapiens	88-96
19473974-10	2009	Based on the location of these sites and available structural information, we propose a refined model of C1 assembly where the CUB(1)-EGF-CUB(2) interaction domains of C1r and C1s are entirely clustered inside C1q and interact through six binding sites with reactive lysines of the C1q stems.	Lysine	267-274	complement C1s	Homo sapiens	176-179
19443658-3	2009	The leukemogenic CALM-AF10 fusion protein is capable of interacting with the histone H3 lysine 79 (H3K79)-specific methyltransferase hDOT1L through the fused AF10 moiety.	Lysine	88-94	DOT1 like histone lysine methyltransferase	Homo sapiens	133-139
19617712-4	2009	Here we report that human double minute-2 protein (HDM2), a p53-specific E3 ubiquitin ligase, specifically ubiquitinates HEXIM1 through the lysine residues located within the basic region of HEXIM1.	Lysine	140-146	HEXIM P-TEFb complex subunit 1	Homo sapiens	121-127
19617712-4	2009	Here we report that human double minute-2 protein (HDM2), a p53-specific E3 ubiquitin ligase, specifically ubiquitinates HEXIM1 through the lysine residues located within the basic region of HEXIM1.	Lysine	140-146	tumor protein p53	Homo sapiens	60-63
19617712-4	2009	Here we report that human double minute-2 protein (HDM2), a p53-specific E3 ubiquitin ligase, specifically ubiquitinates HEXIM1 through the lysine residues located within the basic region of HEXIM1.	Lysine	140-146	HEXIM P-TEFb complex subunit 1	Homo sapiens	191-197
19422794-3	2009	Here, we show that calpain-2, a protease involved in cell motility, can be SUMO modified at lysine residue 390.	Lysine	92-98	calpain 2	Homo sapiens	19-28
19553542-4	2009	Immunoblotting demonstrates that c-Maf can be modified at lysine 33 by SUMO-1 (small ubiquitin-like modifier 1).	Lysine	58-64	small ubiquitin-like modifier 1	Mus musculus	71-77
19553542-4	2009	Immunoblotting demonstrates that c-Maf can be modified at lysine 33 by SUMO-1 (small ubiquitin-like modifier 1).	Lysine	58-64	small ubiquitin-like modifier 1	Mus musculus	79-110
19422794-4	2009	Converting the SUMO acceptor lysine residue to arginine residue significantly attenuated calpain-2 activity, correlating well with a loss of calpain-2-elicited cell motility.	Lysine	29-35	calpain 2	Homo sapiens	89-98
19422794-4	2009	Converting the SUMO acceptor lysine residue to arginine residue significantly attenuated calpain-2 activity, correlating well with a loss of calpain-2-elicited cell motility.	Lysine	29-35	calpain 2	Homo sapiens	141-150
19439417-2	2009	Similar to other members of the short chain alcohol dehydrogenase/reductase family of enzymes, POR contains a conserved Tyr and Lys residue in the enzyme active site, which are implicated in a proposed reaction mechanism involving proton transfer from the Tyr hydoxyl group to Pchlide.	Lysine	128-131	cytochrome p450 oxidoreductase	Homo sapiens	95-98
19462393-1	2009	A mechanism for triflusal-induced photoallergy involving complexation of 2-hydroxy-4-trifluoromethylbenzoic acid with site I of human serum albumin and subsequent formation of a covalent adduct by photoreaction between a metabolite and a neighboring lysine residue is proposed.	Lysine	250-256	albumin	Homo sapiens	134-147
19572292-4	2009	Addition of 3.0 g citraconic anhydride per g protein into the reaction solution led to the citraconylation of lysine residues in human proinsulin and reduction of relative des-threonine insulin content from 13.5 to 1.0%.	Lysine	110-116	insulin	Homo sapiens	135-145
19572292-4	2009	Addition of 3.0 g citraconic anhydride per g protein into the reaction solution led to the citraconylation of lysine residues in human proinsulin and reduction of relative des-threonine insulin content from 13.5 to 1.0%.	Lysine	110-116	insulin	Homo sapiens	138-145
19572292-5	2009	After the enzymatic hydrolysis of the citraconylated proinsulin, 100% of lysine residues can be decitraconylated and restored by adjusting pH to 2-3 at 25 degrees C. Combination of hydrogen peroxide addition and citraconylation of proinsulin expressed in recombinant Escherichia coli remarkably improved the conversion yield of insulin from 52.7 to 77.7%.	Lysine	73-79	insulin	Homo sapiens	53-63
19572292-5	2009	After the enzymatic hydrolysis of the citraconylated proinsulin, 100% of lysine residues can be decitraconylated and restored by adjusting pH to 2-3 at 25 degrees C. Combination of hydrogen peroxide addition and citraconylation of proinsulin expressed in recombinant Escherichia coli remarkably improved the conversion yield of insulin from 52.7 to 77.7%.	Lysine	73-79	insulin	Homo sapiens	231-241
19572292-5	2009	After the enzymatic hydrolysis of the citraconylated proinsulin, 100% of lysine residues can be decitraconylated and restored by adjusting pH to 2-3 at 25 degrees C. Combination of hydrogen peroxide addition and citraconylation of proinsulin expressed in recombinant Escherichia coli remarkably improved the conversion yield of insulin from 52.7 to 77.7%.	Lysine	73-79	insulin	Homo sapiens	56-63
19572292-6	2009	Consequently, citraconylation of lysine residues blocked the unexpected cleavage of human proinsulin by trypsin, minimized the formation of des-threonine insulin and hence increased the production yield of active insulin.	Lysine	33-39	insulin	Homo sapiens	90-100
19572292-6	2009	Consequently, citraconylation of lysine residues blocked the unexpected cleavage of human proinsulin by trypsin, minimized the formation of des-threonine insulin and hence increased the production yield of active insulin.	Lysine	33-39	insulin	Homo sapiens	93-100
19572292-6	2009	Consequently, citraconylation of lysine residues blocked the unexpected cleavage of human proinsulin by trypsin, minimized the formation of des-threonine insulin and hence increased the production yield of active insulin.	Lysine	33-39	insulin	Homo sapiens	154-161
19432880-4	2009	In addition, the Mdmx mutant cooperates with Mdm2 to induce ubiquitination of p53 at C-terminal lysine residues, and the integrity of the C-terminal lysines was partly required for the cooperative inhibition.	Lysine	96-102	tumor protein p53	Homo sapiens	78-81
19432880-4	2009	In addition, the Mdmx mutant cooperates with Mdm2 to induce ubiquitination of p53 at C-terminal lysine residues, and the integrity of the C-terminal lysines was partly required for the cooperative inhibition.	Lysine	149-156	tumor protein p53	Homo sapiens	78-81
19483673-6	2009	Two lysine residues in the YB-1 carboxy-terminal domain are crucial for its release, probably because of post-translational modifications.	Lysine	4-10	Y-box binding protein 1	Homo sapiens	27-31
19398503-3	2009	We have previously shown that mutations of Lys(332) in transmembrane helix (TM) 6 and Trp(1246) in TM17 cause different substrate-selective losses in MRP1 transport activity.	Lysine	43-46	ATP binding cassette subfamily B member 1	Homo sapiens	150-154
19498464-1	2009	Trimethylation of lysine 9 in histone H3 (H3K9me3) enrichment is a characteristic of pericentric heterochromatin.	Lysine	18-24	H3 clustered histone 14	Homo sapiens	38-40
19498464-1	2009	Trimethylation of lysine 9 in histone H3 (H3K9me3) enrichment is a characteristic of pericentric heterochromatin.	Lysine	18-24	H3 clustered histone 14	Homo sapiens	42-49
19414603-4	2009	The histone H4 Lys 20 (H4K20) monomethyltransferase PR-Set7/Setd8 gene is upregulated by PPAR gamma during adipogenesis, and the knockdown of PR-Set7/Setd8 suppressed adipogenesis.	Lysine	15-18	peroxisome proliferator activated receptor gamma	Homo sapiens	89-99
19403684-5	2009	We also show that both CD4 and Nef are ubiquitinated on lysine residues, but this modification is dispensable for Nef-induced targeting of CD4 to the MVB pathway.	Lysine	56-62	CD4 molecule	Homo sapiens	23-26
19403684-5	2009	We also show that both CD4 and Nef are ubiquitinated on lysine residues, but this modification is dispensable for Nef-induced targeting of CD4 to the MVB pathway.	Lysine	56-62	S100 calcium binding protein B	Homo sapiens	31-34
19535349-8	2009	In particular, histone H3 specific methylation at lysine 79 catalyzed by DOT1L has been recognized as a hallmark of chromatin activated by MLL fusion proteins.	Lysine	50-56	DOT1 like histone lysine methyltransferase	Homo sapiens	73-78
19522825-3	2009	As part of a protein complex that writes a trimethyl mark on lysine 4 of histone H3 (H3K4me3), menin is involved in activating gene transcription.	Lysine	61-67	menin 1	Homo sapiens	95-100
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	signal transducer and activator of transcription 3	Homo sapiens	79-84
19416725-5	2009	This suggests that acetylation at Lys-120 of p53 negatively regulates a signaling pathway leading to NFAT activation.	Lysine	34-37	tumor protein p53	Homo sapiens	45-48
19427866-2	2009	We show here that the nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains.	Lysine	47-53	ubiquitin B	Homo sapiens	72-87
21475861-9	2009	In a recent study using protein-specific anti-acetyl lysine antibodies and immunological methods, we demonstrated the ability of aspirin to acetylate the tumor suppressor protein p53.	Lysine	53-59	tumor protein p53	Homo sapiens	179-182
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	signal transducer and activator of transcription 3	Homo sapiens	125-130
19523899-5	2009	Crystal structures of both Gab2 epitopes complexed with Grb2SH3C reveal that Gab2b contains a 3(10) helix that positions the arginine and lysine of the core-binding motif RxxK in parallel orientation.	Lysine	138-144	GRB2 associated binding protein 2	Homo sapiens	27-31
19516333-5	2009	Antagonizing activities of Sir2 and Sas2, a histone acetyltransferase, regulate the replicative lifespan through histone H4 lysine 16 at subtelomeric regions.	Lysine	124-130	histone acetyltransferase	Saccharomyces cerevisiae S288C	36-40
19339512-7	2009	Such PRL effects on paracellular transport were completely abolished by inhibitors of PI3K (LY-294002) and ROCK (Y-27632).	Lysine	92-94	prolactin	Homo sapiens	5-8
19486666-11	2009	To alleviate the desolvation cost, in MCP and MCP-GpA dimers, Lys-40 gets deprotonated.	Lysine	62-65	glycophorin A (MNS blood group)	Homo sapiens	46-53
19351806-9	2009	Visfatin increased total Akt and Ser(473)-phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser(1177); these effects were blocked by LY-2940002.	Lysine	156-158	AKT serine/threonine kinase 1	Homo sapiens	25-28
19351806-9	2009	Visfatin increased total Akt and Ser(473)-phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser(1177); these effects were blocked by LY-2940002.	Lysine	156-158	AKT serine/threonine kinase 1	Homo sapiens	50-53
19327396-6	2009	Insulin induces dose dependent changes in Lysine 4 and 9 methylation, Ser 10 phosphorylation and acetylation of histone H3.	Lysine	42-48	insulin	Homo sapiens	0-7
19351806-9	2009	Visfatin increased total Akt and Ser(473)-phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser(1177); these effects were blocked by LY-2940002.	Lysine	156-158	nitric oxide synthase 3	Homo sapiens	91-95
19369477-1	2009	The human cytomegalovirus (CMV) pp65 protein contains two bipartite nuclear localization signals (NLSs) at amino acids (aa) 415 to 438 and aa 537 to 561 near the carboxy terminus of CMV pp65 and a phosphate binding site related to kinase activity at lysine-436.	Lysine	250-256	lymphocyte cytosolic protein 1	Mus musculus	32-36
19458056-7	2009	RESULTS: The ERalpha promoter in the ERalpha-negative lines MDA-MB-231, MCF10A, and MCF7-5C show CpG island methylation, histone 3 lysine 9 deacetylation, and decreased chromatin accessibility compared with ERalpha-positive cell lines MCF7 and T47-D.	Lysine	131-137	estrogen receptor 1	Homo sapiens	13-20
19458056-7	2009	RESULTS: The ERalpha promoter in the ERalpha-negative lines MDA-MB-231, MCF10A, and MCF7-5C show CpG island methylation, histone 3 lysine 9 deacetylation, and decreased chromatin accessibility compared with ERalpha-positive cell lines MCF7 and T47-D.	Lysine	131-137	estrogen receptor 1	Homo sapiens	37-44
19458056-7	2009	RESULTS: The ERalpha promoter in the ERalpha-negative lines MDA-MB-231, MCF10A, and MCF7-5C show CpG island methylation, histone 3 lysine 9 deacetylation, and decreased chromatin accessibility compared with ERalpha-positive cell lines MCF7 and T47-D.	Lysine	131-137	estrogen receptor 1	Homo sapiens	37-44
19131354-10	2009	One (p.K301M) produced a lysine to methionine change in the third interactive SH3 domain (position 301) and resulted in the defective CD2-CD2AP interaction and clustering; the other (c.1573delAGA) caused the deletion of the glutamic acid in position 525 in the COOH-terminal region of binding with nephrin and was associated with down-modulation of CD2AP, podocin and nephrin glomerular expression.	Lysine	25-31	NPHS2 stomatin family member, podocin	Homo sapiens	356-363
19272447-2	2009	Nvarepsilon-(propanoyl)lysine (propionyllysine, or PRL) is formed from the reaction of the oxidized products of n-3 PUFAs and lysine.	Lysine	23-29	prolactin	Homo sapiens	51-54
19593652-7	2009	Molecular modeling of human cyt c shows that the omega loop where the lysine residue is located apparently further away from heme in human cyt c than in yeast iso-1 and horse heart cyt c.	Lysine	70-76	cytochrome c, somatic	Homo sapiens	28-33
19593652-7	2009	Molecular modeling of human cyt c shows that the omega loop where the lysine residue is located apparently further away from heme in human cyt c than in yeast iso-1 and horse heart cyt c.	Lysine	70-76	cytochrome c, somatic	Homo sapiens	139-144
19593652-7	2009	Molecular modeling of human cyt c shows that the omega loop where the lysine residue is located apparently further away from heme in human cyt c than in yeast iso-1 and horse heart cyt c.	Lysine	70-76	cytochrome c, somatic	Homo sapiens	139-144
19460296-6	2009	Furthermore, the mto1 strains exhibited a marked reduction in the aminoacylation levels of mitochondrial tRNA(Lys), tRNA(Leu), tRNA(Arg) but almost no effect in those of tRNA(His).	Lysine	110-113	tRNA modification protein MTO1	Saccharomyces cerevisiae S288C	17-21
19386364-0	2009	Copper.Lys-Gly-His-Lys mediated cleavage of tRNA(Phe): studies of reaction mechanism and cleavage specificity.	Lysine	7-10	mitochondrially encoded tRNA glycine	Homo sapiens	44-53
19359250-6	2009	Consistent with a methyltransferase-independent function for Rmt3 in small ribosomal subunit production, the expression of an Rps2 variant in which the identified methylarginine residues were substituted with lysines showed normal levels of 40 S subunit.	Lysine	209-216	ribosomal protein S2	Homo sapiens	126-130
21136982-4	2009	Here, in vitro studies on HSA have shown by MS that the modification of protein lysine residues occurs in a dose-, time- and site-dependent manner.	Lysine	80-86	albumin	Homo sapiens	26-29
19366580-5	2009	Using a recombinant infectious clone of RP-9, we found that a single Glu--&gt;Lys mutation at residue 138 of the envelope protein (E-E138K) rendered the mutated RP-9 sensitive to the antiviral effect of IFN-alpha.	Lysine	78-81	interferon alpha 1	Homo sapiens	203-212
19413317-2	2009	Among the compounds thus designed and synthesized, we found that 2k, which contains an ethoxycarbonyl group at the alpha position to the acetamide of acetylated lysine substrate analogue 1, showed potent inhibitory activity in an in vitro assay using recombinant SIRT1, with high selectivity over SIRT2 and SIRT3.	Lysine	161-167	sirtuin 3	Homo sapiens	307-312
19439100-11	2009	Both methionine-lysine-bradykinin and labradimil increased the blood half-life of Gd-DTPA sufficiently enough to increase significantly the tumor tissue Gd-DTPA area under the time-concentration curve.	Lysine	16-22	kininogen 1	Homo sapiens	23-33
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	46-52	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	33-37
19164286-7	2009	Using this approach, we identified the glutamine and lysine residues involved in tTG-catalyzed intramolecular cross-linking of alpha-syn.	Lysine	53-59	transglutaminase 2	Homo sapiens	81-84
19334741-1	2009	Lysine methylation is an important post-translational modification that affects protein function; for example, the transcriptional activity of the p53 tumor suppressor protein.	Lysine	0-6	tumor protein p53	Homo sapiens	147-150
19334741-3	2009	The method, which relies on the synthesis of (13)C-enriched alkylating agents, was applied to the production of 15-residue p53 peptides variously methylated at lysine analogue 370.	Lysine	160-166	tumor protein p53	Homo sapiens	123-126
19446523-4	2009	The structure reveals a detailed network of interactions between the protein and the amino-terminal residues of histone H3, and particularly key electrostatic interactions of a conserved aspartic acid 297 in AIRE with the unmodified lysine 4 of histone H3 (H3K4).	Lysine	233-239	autoimmune regulator	Homo sapiens	208-212
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	58-61	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	33-37
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	58-61	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	152-156
19270680-0	2009	CBP/p300-mediated acetylation of histone H3 on lysine 56.	Lysine	47-53	CREB binding protein	Homo sapiens	0-8
19281183-3	2009	Cc2672 was shown to catalyze the hydrolysis of l-Xaa-l-Arg/Lys dipeptides and the N-acetyl and N-formyl derivatives of lysine and arginine.	Lysine	59-62	Xaa-Pro dipeptidase	Caulobacter vibrioides CB15	0-6
19454348-1	2009	The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity.	Lysine	37-43	interferon alpha 1	Homo sapiens	144-167
19281183-3	2009	Cc2672 was shown to catalyze the hydrolysis of l-Xaa-l-Arg/Lys dipeptides and the N-acetyl and N-formyl derivatives of lysine and arginine.	Lysine	119-125	Xaa-Pro dipeptidase	Caulobacter vibrioides CB15	0-6
19281183-5	2009	The N-methyl phosphonate derivative of l-lysine was a potent competitive inhibitor of Cc2672 with a K(i) value of 120 nM.	Lysine	39-47	Xaa-Pro dipeptidase	Caulobacter vibrioides CB15	86-92
19390154-6	2009	The Arg292--&gt;Lys mutation reduces the electrostatic interactions of the enzyme with the acidic group at C2 for all inhibitors that have been studied (SIA, DAN, 4AM, ZMR, G20, G28, G39 and BCZ), but enhances the interactions with the glycerol group at C6 for inhibitors that contain it.	Lysine	16-19	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
19141540-0	2009	Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.	Lysine	146-152	nuclear receptor subfamily 3 group C member 1	Homo sapiens	90-113
19383828-12	2009	Two lysine-rich regions (NLS-1 and NLS-3) can target LYRIC/AEG-1 to subcellular compartments whereas NLS-2 is modified by ubiquitin in the cytoplasm.	Lysine	4-10	major facilitator superfamily domain containing 2A	Homo sapiens	25-30
19383828-12	2009	Two lysine-rich regions (NLS-1 and NLS-3) can target LYRIC/AEG-1 to subcellular compartments whereas NLS-2 is modified by ubiquitin in the cytoplasm.	Lysine	4-10	metadherin	Homo sapiens	53-58
19383828-12	2009	Two lysine-rich regions (NLS-1 and NLS-3) can target LYRIC/AEG-1 to subcellular compartments whereas NLS-2 is modified by ubiquitin in the cytoplasm.	Lysine	4-10	metadherin	Homo sapiens	59-64
19292763-7	2009	This is a novel epitope, because the clone responds to proinsulin but not to insulin, T cell recognition requires the last two residues of the C-peptide (Lys, Arg) and recognition does not depend upon a vicinal disulphide bond between the A6 and A7 cysteines.	Lysine	154-157	insulin	Homo sapiens	58-65
19141540-6	2009	CLOCK and GR interacted with each other physically, and CLOCK suppressed binding of GR to its DNA recognition sequences by acetylating multiple lysine residues located in its hinge region.	Lysine	144-150	nuclear receptor subfamily 3 group C member 1	Homo sapiens	84-86
19264595-4	2009	We show that, while NS2-lysine mutagenesis of protease-inactive NS2/3 results in a partial stabilization of this protein, the increased NS2/3 levels do not rescue the inability of NS2/3 protease inactive replicons to replicate, suggesting that uncleaved NS2/3 is unable to functionally replace NS3 in RNA replication.	Lysine	24-30	NS2	Homo sapiens	20-23
19264595-4	2009	We show that, while NS2-lysine mutagenesis of protease-inactive NS2/3 results in a partial stabilization of this protein, the increased NS2/3 levels do not rescue the inability of NS2/3 protease inactive replicons to replicate, suggesting that uncleaved NS2/3 is unable to functionally replace NS3 in RNA replication.	Lysine	24-30	NS2	Homo sapiens	64-69
19264595-4	2009	We show that, while NS2-lysine mutagenesis of protease-inactive NS2/3 results in a partial stabilization of this protein, the increased NS2/3 levels do not rescue the inability of NS2/3 protease inactive replicons to replicate, suggesting that uncleaved NS2/3 is unable to functionally replace NS3 in RNA replication.	Lysine	24-30	NS2	Homo sapiens	64-67
19359474-4	2009	Mutational analyses were combined with this prototypic structure for the (6-4) PHR/clock CRY cluster to identify structural and functional motifs: phosphate-binding and Pro-Lys-Leu protrusion motifs constricting access to the substrate-binding cavity above FAD, sulfur loop near the external end of the Trp electron-transfer pathway, and previously undefined C-terminal helix.	Lysine	173-176	MYC binding protein 2	Homo sapiens	79-82
19330029-3	2009	Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types.	Lysine	64-70	lysine demethylase 6A	Homo sapiens	88-91
19255092-7	2009	The tandem chromodomains of CHD8 bind in vitro specifically to histone H3 di-methylated at lysine 4.	Lysine	91-97	chromodomain helicase DNA binding protein 8	Homo sapiens	28-32
19265193-1	2009	Acetylation of p53 at carboxyl-terminal lysine residues enhances its transcriptional activity associated with cell cycle arrest and apoptosis.	Lysine	40-46	tumor protein p53	Homo sapiens	15-18
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	44-47	tumor protein p53	Homo sapiens	25-28
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	44-47	BCL2 associated X, apoptosis regulator	Homo sapiens	132-135
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	52-55	tumor protein p53	Homo sapiens	25-28
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	52-55	BCL2 associated X, apoptosis regulator	Homo sapiens	132-135
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	52-55	tumor protein p53	Homo sapiens	25-28
19265193-2	2009	Here we demonstrate that p53 acetylation at Lys-320/Lys-373/Lys-382 is also required for its transcription-independent functions in BAX activation, reactive oxygen species production, and apoptosis in response to the histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid and LAQ824.	Lysine	52-55	BCL2 associated X, apoptosis regulator	Homo sapiens	132-135
19273602-5	2009	We have identified multiple acetylated lysine residues within the Nrf2 Neh1 DNA-binding domain.	Lysine	39-45	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
19273602-6	2009	Combined lysine-to-arginine mutations on the acetylation sites, with no effects on Nrf2 protein stability, compromised the DNA-binding activity of Nrf2 in a promoter-specific manner.	Lysine	9-15	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
19251700-5	2009	SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR.	Lysine	25-31	histone deacetylase 5	Homo sapiens	110-115
19262565-0	2009	Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.	Lysine	57-63	nuclear factor kappa B subunit 1	Homo sapiens	23-32
19233846-5	2009	Moreover, at the promoter of the gene for p16(Ink4a) in Jdp2(-/-) MEF, the extent of methylation of lysine 27 of histone H3 (H3K27), which is important for gene silencing, increased.	Lysine	100-106	cyclin dependent kinase inhibitor 2A	Mus musculus	42-45
19233846-5	2009	Moreover, at the promoter of the gene for p16(Ink4a) in Jdp2(-/-) MEF, the extent of methylation of lysine 27 of histone H3 (H3K27), which is important for gene silencing, increased.	Lysine	100-106	cyclin dependent kinase inhibitor 2A	Mus musculus	46-51
19168731-8	2009	Mass spectrometric analyses of IL-4 and IL-5 showed that hydrolysis by RgpA-Kgp complexes was C terminal to Arg and Lys residues of the cytokines.	Lysine	116-119	interleukin 4	Homo sapiens	31-35
19272776-2	2009	Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-activity relationships against HDAC1 and HDAC6 isotypes as well as 293T cells.	Lysine	83-89	histone deacetylase 1	Homo sapiens	150-155
19272776-2	2009	Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-activity relationships against HDAC1 and HDAC6 isotypes as well as 293T cells.	Lysine	83-89	histone deacetylase 6	Homo sapiens	160-165
19377285-4	2009	Based on studies in our laboratory, we have recently proposed a model for how the methylated lysine 27 of histone H3 (H3K27) can be stably transmitted through the cell division cycle.	Lysine	93-99	H3 clustered histone 14	Homo sapiens	114-116
19377285-4	2009	Based on studies in our laboratory, we have recently proposed a model for how the methylated lysine 27 of histone H3 (H3K27) can be stably transmitted through the cell division cycle.	Lysine	93-99	H3 clustered histone 14	Homo sapiens	118-123
19189944-1	2009	Methylation of histone H3 lysine 9 (H3K9) is a key feature of silent chromatin and plays an important role in stabilizing the interaction of heterochromatin protein 1 (HP1) with chromatin.	Lysine	26-32	Suppressor of variegation 205	Drosophila melanogaster	141-166
19189944-1	2009	Methylation of histone H3 lysine 9 (H3K9) is a key feature of silent chromatin and plays an important role in stabilizing the interaction of heterochromatin protein 1 (HP1) with chromatin.	Lysine	26-32	Suppressor of variegation 205	Drosophila melanogaster	168-171
19296689-1	2009	The effect of introducing positive charges (lysines) in human cytochrome c (cyt c) on the redox properties and reaction rates of cyt c with superoxide radicals was studied.	Lysine	44-51	cytochrome c, somatic	Homo sapiens	62-74
19296689-1	2009	The effect of introducing positive charges (lysines) in human cytochrome c (cyt c) on the redox properties and reaction rates of cyt c with superoxide radicals was studied.	Lysine	44-51	cytochrome c, somatic	Homo sapiens	76-81
19296689-1	2009	The effect of introducing positive charges (lysines) in human cytochrome c (cyt c) on the redox properties and reaction rates of cyt c with superoxide radicals was studied.	Lysine	44-51	cytochrome c, somatic	Homo sapiens	129-134
19227973-0	2009	Lysine-81 and threonine-82 on maize beta-glucosidase isozyme Glu1 are the key amino acids involved in beta-glucosidase aggregating factor binding.	Lysine	0-6	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	Zea mays	61-65
19436139-3	2009	Additionally, we revealed that decrease of adiponectin gene expression by treatment with TNFalpha, an inducer of insulin resistance in adipocytes, was associated with decreased acetylation of histone H3 at lysine 9 on the gene, but not methylations.	Lysine	206-212	tumor necrosis factor	Mus musculus	89-97
19367731-5	2009	RESULTS: The essential Cys36 and four lysine residues in adiponectin, and transmembrane-spanning domains in AdipoR1 and AdipoR2 appear well conserved.	Lysine	38-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	57-68
19307613-7	2009	beta-Casein f(69-209), originating from the early hydrolysis of Lys(68)-Ser(69) by plasmin, has no counterpart in bovine milk.	Lysine	64-67	casein beta	Bos taurus	0-11
19188440-7	2009	HCF-1 is K48 and K63 ubiquitinated, with a major site of linkage at lysines 1807 and 1808 in the HCF-1(C) subunit.	Lysine	68-75	host cell factor C1	Mus musculus	0-5
19118899-5	2009	Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1.	Lysine	37-43	karyopherin subunit alpha 1	Homo sapiens	18-23
19139279-4	2009	Here, we demonstrate that Mot1 is SUMOylated in vivo and that disrupting the Slx5-Slx8 pathway by mutation of the target lysines in Mot1, by deletion of SLX5 or the ubiquitin E2 UBC4, or by inhibition of the proteosome suppresses mot1-301 mutant phenotypes and increases the stability of the Mot1-301 protein.	Lysine	121-128	SUMO-targeted ubiquitin ligase complex subunit SLX8	Saccharomyces cerevisiae S288C	82-86
19343071-3	2009	GCN5 specifically acetylates CDC6 at three lysine residues flanking its cyclin-docking motif, and this modification is crucial for the subsequent phosphorylation of the protein by Cyclin A-CDKs at a specific residue close to the acetylation site.	Lysine	43-49	cell division cycle 6	Homo sapiens	29-33
19295512-6	2009	Here we show that STAT3 phosphorylation and function in the liver were tightly regulated by the nutritional status of an animal, through SirT1-mediated deacetylation of key STAT3 lysine sites.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	18-23
19295512-6	2009	Here we show that STAT3 phosphorylation and function in the liver were tightly regulated by the nutritional status of an animal, through SirT1-mediated deacetylation of key STAT3 lysine sites.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	173-178
19223465-1	2009	PR-Set7/Set8/KMT5A is the sole enzyme known to catalyze monomethylation of histone H4 lysine 20 (H4K20) and is present only in multicellular organisms that compact a large fraction of their DNA.	Lysine	86-92	lysine methyltransferase 5A	Mus musculus	0-7
19223465-1	2009	PR-Set7/Set8/KMT5A is the sole enzyme known to catalyze monomethylation of histone H4 lysine 20 (H4K20) and is present only in multicellular organisms that compact a large fraction of their DNA.	Lysine	86-92	lysine methyltransferase 5A	Mus musculus	13-18
19212323-9	2009	In differentiating wild-type subventricular zone cells, Mash1, Olig2 and Dlx2 loci have high levels of histone 3 trimethylated at lysine 4 (H3K4me3), consistent with their transcription.	Lysine	130-136	oligodendrocyte transcription factor 2	Mus musculus	63-68
19233651-3	2009	We performed a 4-year clinical and audiological follow up in a family carrying the 8363G&gt;A mutation in the mitochondrial transfer ribonucleic acid lysine (tRNA(Lys)) gene who displayed a progressive neuromuscular disease.	Lysine	150-156	mitochondrially encoded tRNA glycine	Homo sapiens	158-167
19351588-6	2009	Further methyltransferase assays focusing on the six lysine residues showed that K78 and K89 are preferentially methylated in full-length PCAF in vitro.	Lysine	53-59	keratin 78	Homo sapiens	81-84
19308286-6	2009	Moreover, our results demonstrated that FoxO1 acetylation is required for the depsipeptide-induced activation of Bim and apoptosis, using transfection with a plasmid containing FoxO1 mutated at lysine sites and a luciferase reporter assay.	Lysine	194-200	forkhead box O1	Homo sapiens	40-45
19361442-6	2009	The carboxylate residues that coordinate two Ca(2+) in the NCX1-CBD1 structure are neutralized by two Lys residues in CALX1.1-CBD2.	Lysine	102-105	solute carrier family 8 member A1	Homo sapiens	59-63
19155214-0	2009	Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.	Lysine	11-17	histone deacetylase 1	Homo sapiens	75-79
18954305-3	2009	Biochemical analysis reveals that OTUB1 has a preference for cleaving Lys(48)-linked polyubiquitin chains over Lys(63)-linked polyubiquitin chains, and it is capable of cleaving NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8), but not SUMO (small ubiquitin-related modifier) 1/2/3 and ISG15 (interferon-stimulated gene 15) conjugates.	Lysine	70-73	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	34-39
19221494-4	2009	p53 activity is influenced by post-translational modifications, including phosphorylation and lysine methylation.	Lysine	94-100	tumor protein p53	Homo sapiens	0-3
19074424-0	2009	The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.	Lysine	35-41	coagulation factor II, thrombin	Homo sapiens	103-111
19199479-1	2009	Introduction of lipoamino acid (LAA), Lys-palmitoyl, and cationization into a series of galanin analogues yielded systemically active anticonvulsant compounds.	Lysine	38-41	galanin and GMAP prepropeptide	Mus musculus	88-95
19046801-12	2009	Mutations of p53 determined in NHL cases (30%) were of Arg-176 (1/20: 5%), Phe-238 (1/20: 5%), Ser-249 (2/20; 10%), Lys-249 (1/20: 5%) and Phe-250 (1/20: 5%).	Lysine	116-119	tumor protein p53	Homo sapiens	13-16
19117940-2	2009	Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta.	Lysine	76-82	major histocompatibility complex, class II, DR beta 1	Homo sapiens	134-144
19117940-3	2009	We show that lysine residue 219 in the cytoplasmic tail of DRalpha is also subject to polyubiquitination.	Lysine	13-19	solute carrier family 26 member 3	Homo sapiens	59-66
19117940-6	2009	In contrast, although lysine 219 is absolutely required for modification of DRalpha, other features of the DRalpha tail act to limit the extent of ubiquitination.	Lysine	22-28	solute carrier family 26 member 3	Homo sapiens	76-83
22444306-7	2009	Milk protein concentration and casein yield tended (P &lt; 0.10) to decrease with Lys deletion, while Lys secretion in milk protein was lowered (P &lt; 0.05).	Lysine	82-85	casein beta	Bos taurus	0-12
22444306-11	2009	Nonetheless, while Lys deletion decreased mammary uptake by 10.1 mmol/h, Lys in milk protein secretion was reduced by only 3.9 mmol/h.	Lysine	73-76	casein beta	Bos taurus	80-92
18991813-9	2009	On the basis of our results, a catalytic mechanism is proposed for hPHPT1: the imidazole ring of His(53) serves as a general base to activate a water molecule, and the activated water would attack the substrate as a nucleophile in the catalysis; the positively charged side chain of Lys(21) can help stabilize the transition state.	Lysine	283-286	phosphohistidine phosphatase 1	Homo sapiens	67-73
18954305-3	2009	Biochemical analysis reveals that OTUB1 has a preference for cleaving Lys(48)-linked polyubiquitin chains over Lys(63)-linked polyubiquitin chains, and it is capable of cleaving NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8), but not SUMO (small ubiquitin-related modifier) 1/2/3 and ISG15 (interferon-stimulated gene 15) conjugates.	Lysine	111-114	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	34-39
18954305-5	2009	Mutational analysis suggested that a narrow P1" site, as observed in OTUB1, correlates with its ability to preferentially cleave Lys(48)-linked ubiquitin chains.	Lysine	129-132	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	69-74
19074527-1	2009	Cytochrome P450 (P450) 2B6 metabolizes a number of clinically relevant drugs and is one of the most highly polymorphic human P450 enzymes, with the Lys(262)--&gt;Arg substitution being especially common in several genetic variants.	Lysine	148-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26
19252254-3	2009	The most common mutation found is the Asn540Lys (asparagine to lysine transition-N540K) in the intracellular tyrosine-kinase (TK1) region.	Lysine	63-69	thymidine kinase 1	Homo sapiens	126-129
19106109-0	2009	p53 Oligomerization is essential for its C-terminal lysine acetylation.	Lysine	52-58	tumor protein p53	Homo sapiens	0-3
19208765-4	2009	Binding of the Ist2 sorting signal to lipids and rapid and efficient transport of Ist2 from perinuclear to cortical ER depend on a cluster of lysine residues, the formation of an amphipathic alpha-helix and a patch of hydrophobic side chains positioned at one side of the amphipathic alpha-helix.	Lysine	142-148	Ist2p	Saccharomyces cerevisiae S288C	15-19
19208765-4	2009	Binding of the Ist2 sorting signal to lipids and rapid and efficient transport of Ist2 from perinuclear to cortical ER depend on a cluster of lysine residues, the formation of an amphipathic alpha-helix and a patch of hydrophobic side chains positioned at one side of the amphipathic alpha-helix.	Lysine	142-148	Ist2p	Saccharomyces cerevisiae S288C	82-86
19103749-1	2009	Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression of inflammatory genes.	Lysine	60-66	nuclear factor kappa B subunit 1	Homo sapiens	35-44
19103749-1	2009	Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression of inflammatory genes.	Lysine	60-66	nuclear factor kappa B subunit 1	Homo sapiens	122-131
19103749-2	2009	In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310.	Lysine	75-81	bromodomain containing 4	Homo sapiens	51-55
19103749-3	2009	Brd4 enhances transcriptional activation of NF-kappaB and the expression of a subset of NF-kappaB-responsive inflammatory genes in an acetylated lysine-310-dependent manner.	Lysine	145-151	bromodomain containing 4	Homo sapiens	0-4
19103749-3	2009	Brd4 enhances transcriptional activation of NF-kappaB and the expression of a subset of NF-kappaB-responsive inflammatory genes in an acetylated lysine-310-dependent manner.	Lysine	145-151	nuclear factor kappa B subunit 1	Homo sapiens	44-53
19103749-3	2009	Brd4 enhances transcriptional activation of NF-kappaB and the expression of a subset of NF-kappaB-responsive inflammatory genes in an acetylated lysine-310-dependent manner.	Lysine	145-151	nuclear factor kappa B subunit 1	Homo sapiens	88-97
19103749-4	2009	Bromodomains of Brd4 and acetylated lysine-310 of RelA are both required for the mutual interaction and coactivation function of Brd4.	Lysine	36-42	bromodomain containing 4	Homo sapiens	129-133
19103749-6	2009	Our results identify Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA.	Lysine	105-111	bromodomain containing 4	Homo sapiens	21-25
19103749-6	2009	Our results identify Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA.	Lysine	105-111	nuclear factor kappa B subunit 1	Homo sapiens	52-61
19166815-2	2009	We created mutants at the target sites (lysines 2 and 81) in the tailless HMGB1 modified by the histone acetyltransferase CBP.	Lysine	40-47	CREB binding protein	Homo sapiens	122-125
19250910-7	2009	Interestingly, processing requires multiple monoubiquitinations, because progressive elimination of lysines in p105 is accompanied by gradual inhibition of p50 generation.	Lysine	100-107	nuclear factor kappa B subunit 1	Homo sapiens	111-115
19106109-1	2009	Acetylation of multiple lysine residues in the p53 plays critical roles in the protein stability and transcriptional activity of p53.	Lysine	24-30	tumor protein p53	Homo sapiens	47-50
19106109-1	2009	Acetylation of multiple lysine residues in the p53 plays critical roles in the protein stability and transcriptional activity of p53.	Lysine	24-30	tumor protein p53	Homo sapiens	129-132
19106109-3	2009	We found that p53 mutants that are defective in tetramer formation are also defective in C-terminal lysine residue acetylation.	Lysine	100-106	tumor protein p53	Homo sapiens	14-17
19106109-4	2009	Consistently, we found that several cancer-derived p53 mutants that bear mutations in the tetramerization domain cannot form oligomers and are defective in C-terminal lysine acetylation, and these mutants are inactive in p21 transactivation.	Lysine	167-173	tumor protein p53	Homo sapiens	51-54
19188499-4	2009	In Gfi1(-/-) Th2 cells, the Rorc, Il23r, and Cd103 loci showed histone 3 lysine 4 trimethylation modifications that were lacking in wild-type Th2 cells, implying that Gfi-1 is critical for epigenetic regulation of Th17 and iTreg cell-related genes in Th2 cells.	Lysine	73-79	interleukin 23 receptor	Mus musculus	34-39
19179064-0	2009	Modifications of p53: competing for the lysines.	Lysine	40-47	tumor protein p53	Homo sapiens	17-20
19179283-3	2009	The widely used mouse strain C57BL/6J, harbors a SERT haplotype defined by 2 nonsynonymous coding variants [Gly-39 and Lys-152 (GK)].	Lysine	119-122	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	49-53
19103149-5	2009	Nuclear localization of TFPI-2 required a NLS sequence located in its Lys/Arg-rich C-terminal tail comprising residues 191-211, as a TFPI-2 construct lacking the C-terminal tail failed to localize to the nucleus.	Lysine	70-73	tissue factor pathway inhibitor 2	Homo sapiens	24-30
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	79-82	tumor protein p53	Homo sapiens	0-3
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	91-94	tumor protein p53	Homo sapiens	0-3
19100731-4	2009	TNF-alpha-induced hepatocyte DNA synthesis and proliferation were blocked by AG1478 (10(-7) M), PD98059 (10(-6) M), LY 294002 (10(-7) M), and rapamycin (100 ng/ml).	Lysine	116-118	tumor necrosis factor	Rattus norvegicus	0-9
19179064-2	2009	In addition to a multitude of phosphorylated serines and threonines, many of the lysine residues in p53 can be modified to regulate activity, stability and subcellular localization of the protein.	Lysine	81-87	tumor protein p53	Homo sapiens	100-103
19179064-3	2009	This complexity is amplified by the variety of modifications that can target the same lysine residue - often with opposing effects on p53 function.	Lysine	86-92	tumor protein p53	Homo sapiens	134-137
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	124-127	transmembrane p24 trafficking protein 2	Homo sapiens	64-67
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	121-127	CD4 molecule	Homo sapiens	44-47
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	121-127	CD4 molecule	Homo sapiens	165-168
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	121-127	CD4 molecule	Homo sapiens	165-168
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	237-243	CD4 molecule	Homo sapiens	44-47
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	237-243	CD4 molecule	Homo sapiens	165-168
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	237-243	CD4 molecule	Homo sapiens	165-168
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	124-127	tumor protein p53	Homo sapiens	97-100
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	132-135	transmembrane p24 trafficking protein 2	Homo sapiens	64-67
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	132-135	tumor protein p53	Homo sapiens	97-100
19041150-6	2009	In addition, an association of JNK1 activation with the histone H3 lysines 4 and 9 tri-methylation was observed in the HCC tissues, which leads to an elevated expression of genes regulating cell growth and a decreased expression of the genes for cell differentiation and the p450 family members in HCC.	Lysine	67-74	mitogen-activated protein kinase 8	Homo sapiens	31-35
19017645-2	2009	The DNA binding property of HSF2 is modulated by the post-translational modification of a specific lysine residue in its DNA binding domain by small ubiquitin-like modifier (SUMO), but the consequences of SUMOylation and its underlying molecular mechanism remain unclear.	Lysine	99-105	heat shock transcription factor 2	Homo sapiens	28-32
18818687-6	2009	This complex regulates targeted histone H3 Lys-79 methylation of chromatin associated with the ENaCalpha promoter, thereby suppressing its transcriptional activity.	Lysine	43-46	sodium channel epithelial 1 subunit alpha	Homo sapiens	95-104
18818687-7	2009	Aldosterone disrupts the Dot1a-Af9 interaction by serum- and glucocorticoid-induced kinase-1 phosphorylation of Af9, and inhibits Dot1a and Af9 expression, resulting in histone H3 Lys-79 hypomethylation at specific subregions, and derepression of the ENaCalpha promoter.	Lysine	180-183	MLLT3 super elongation complex subunit	Homo sapiens	31-34
18818687-7	2009	Aldosterone disrupts the Dot1a-Af9 interaction by serum- and glucocorticoid-induced kinase-1 phosphorylation of Af9, and inhibits Dot1a and Af9 expression, resulting in histone H3 Lys-79 hypomethylation at specific subregions, and derepression of the ENaCalpha promoter.	Lysine	180-183	MLLT3 super elongation complex subunit	Homo sapiens	112-115
18818687-7	2009	Aldosterone disrupts the Dot1a-Af9 interaction by serum- and glucocorticoid-induced kinase-1 phosphorylation of Af9, and inhibits Dot1a and Af9 expression, resulting in histone H3 Lys-79 hypomethylation at specific subregions, and derepression of the ENaCalpha promoter.	Lysine	180-183	MLLT3 super elongation complex subunit	Homo sapiens	112-115
18840871-3	2009	In the present study we determined the effect of insulin on the secretome by comparing incorporation rates of (13)C-labeled lysine in the presence and absence of insulin.	Lysine	124-130	insulin	Homo sapiens	49-56
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Lysine	131-134	parathyroid hormone	Rattus norvegicus	38-41
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Lysine	131-134	parathyroid hormone	Rattus norvegicus	56-59
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Lysine	135-138	parathyroid hormone	Rattus norvegicus	38-41
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Lysine	135-138	parathyroid hormone	Rattus norvegicus	56-59
19013489-6	2009	The aim of the present study was to synthesize, by the solid phase peptide synthesis method, PTH fragments including the -Arg-Lys-Lys- sequence and test their influence on blood pressure and calcium plasma concentration in rats.	Lysine	126-129	parathyroid hormone	Rattus norvegicus	93-96
19013489-6	2009	The aim of the present study was to synthesize, by the solid phase peptide synthesis method, PTH fragments including the -Arg-Lys-Lys- sequence and test their influence on blood pressure and calcium plasma concentration in rats.	Lysine	130-133	parathyroid hormone	Rattus norvegicus	93-96
19013489-8	2009	The presence of strong alkali sequence -Arg-Lys-Lys- in PTH(25-30) fragment is not sufficient to induce hypertension either in physiological or pharmacological doses in rats.	Lysine	44-47	parathyroid hormone	Rattus norvegicus	56-59
19013489-8	2009	The presence of strong alkali sequence -Arg-Lys-Lys- in PTH(25-30) fragment is not sufficient to induce hypertension either in physiological or pharmacological doses in rats.	Lysine	48-51	parathyroid hormone	Rattus norvegicus	56-59
19033885-8	2009	Molecular modeling suggested that the glutamic acid-233 forms a salt bridge with lysine-23 in the N-terminal domain of RAD51D, and the glycine substitution may disrupt an interdomain interaction.	Lysine	81-87	RAD51 paralog D	Homo sapiens	119-125
19015641-4	2009	The somatic E884K substitution appears to be relatively infrequent and resulted in a mutant lysine residue that disrupts an ion pair with residue R958 in the EGFR kinase domain C-lobe, an interaction that is highly conserved within the human kinome as demonstrated by our sequence analysis and structure analysis.	Lysine	92-98	epidermal growth factor receptor	Homo sapiens	158-162
19011241-2	2009	Specifically, nascent BACE1 is transiently acetylated in seven lysine residues clustered in a highly disordered region of the protein that faces the lumen of the endoplasmic reticulum (ER)/ER Golgi intermediate compartment (ER/ERGIC).	Lysine	63-69	beta-secretase 1	Homo sapiens	22-27
19059208-2	2009	We have reported that Ymer interacts with A20 and lysine (K)-63-linked polyubiquitin chain and that Ymer inhibits NF-kappaB signaling in collaboration with A20.	Lysine	50-56	coiled-coil domain containing 50	Homo sapiens	22-26
19061335-8	2009	When NGF was released from lysine-conjugated pHEMA hydrogels, a significant increase in process growth was observed.	Lysine	27-33	nerve growth factor	Homo sapiens	5-8
19015261-6	2009	We have further identified two functional degradation motifs in Sgo1; that is, a KEN (Lys-Glu-Asn) box and a destruction box (D box).	Lysine	86-89	pericentrin	Homo sapiens	81-84
19084395-3	2009	Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.	Lysine	91-97	histone deacetylase 1	Homo sapiens	126-131
19084395-3	2009	Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.	Lysine	91-97	histone deacetylase 6	Homo sapiens	136-141
18781627-6	2009	It is consistent with the initial experimental rate data for individual lysine residues for cytochrome C.	Lysine	72-78	cytochrome c, somatic	Homo sapiens	92-104
19135889-0	2009	SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.	Lysine	23-29	sirtuin 6	Mus musculus	0-5
19135889-4	2009	SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters.	Lysine	76-82	sirtuin 6	Mus musculus	0-5
19056850-7	2009	On the other hand, the methylation levels of lysine 20 (K20) on histone H4 showed a significant correlation with HP1gamma expression in both these preadipocyte cells and normal tissue samples.	Lysine	45-51	keratin 20	Homo sapiens	56-59
19595309-5	2009	There are, however, still many open questions regarding, for example, whether sirtuins deacetylate those lysine residues in p53 that are critical for its activity.	Lysine	105-111	tumor protein p53	Homo sapiens	124-127
19475480-4	2009	Infection with viruses containing a lysine at NP 184 induced earlier mortality in chickens, increased virus titers and nitric oxide levels in tissues, and resulted in up-regulated host immune genes, such as alpha-interferon (IFN-alpha), gamma-interferon (IFN-gamma), orthomyxovirus resistance gene 1 (Mx1), and inducible nitric oxide synthase (iNOS).	Lysine	36-42	nitric oxide synthase 2	Gallus gallus	311-342
19475480-4	2009	Infection with viruses containing a lysine at NP 184 induced earlier mortality in chickens, increased virus titers and nitric oxide levels in tissues, and resulted in up-regulated host immune genes, such as alpha-interferon (IFN-alpha), gamma-interferon (IFN-gamma), orthomyxovirus resistance gene 1 (Mx1), and inducible nitric oxide synthase (iNOS).	Lysine	36-42	nitric oxide synthase 2	Gallus gallus	344-348
18781627-10	2009	Molecular dynamics simulations showed that for cytochrome C, in general, the two lysines come closer for the observed cross-links as compared to the false positive ones.	Lysine	81-88	cytochrome c, somatic	Homo sapiens	47-59
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Lysine	53-59	coagulation factor II, thrombin	Homo sapiens	203-211
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Lysine	53-59	coagulation factor II, thrombin	Homo sapiens	274-282
19356119-9	2009	Upon examination of the sequence homology and the three-dimensional structures of human PXR and a dog PXR model, only two different amino acids (met323/val and arg410/lys) were found in the ligand-binding domain.	Lysine	167-170	nuclear receptor subfamily 1 group I member 2	Homo sapiens	88-91
18824138-1	2009	The Rad6-Rad18 complex mono-ubiquitinates proliferating cell nuclear antigen (PCNA) at the lysine 164 residue after DNA damage and promotes DNA polymerase eta (Poleta)- and Polzeta/Rev1-dependent DNA synthesis.	Lysine	91-97	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	9-14
18787108-6	2009	CTRP9 is a secreted glycoprotein with multiple post-translational modifications in its collagen domain that include hydroxylated prolines and hydroxylated and glycosylated lysines.	Lysine	172-179	C1q and tumor necrosis factor related protein 9	Mus musculus	0-5
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	195-201	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	42-47
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	195-201	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	221-227
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	195-201	cytochrome P450, family 2, subfamily f, polypeptide 4	Rattus norvegicus	298-304
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	195-201	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	221-226
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	203-206	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	42-47
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	203-206	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	221-227
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	203-206	cytochrome P450, family 2, subfamily f, polypeptide 4	Rattus norvegicus	298-304
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	203-206	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	221-226
20495683-1	2009	Bromodomain-containing protein 4 (Brd4) contains two tandem bromodomains (BD1 and BD2) that bind preferentially to acetylated lysine residues found in histones and nonhistone proteins.	Lysine	126-132	bromodomain containing 4	Homo sapiens	0-32
20495683-1	2009	Bromodomain-containing protein 4 (Brd4) contains two tandem bromodomains (BD1 and BD2) that bind preferentially to acetylated lysine residues found in histones and nonhistone proteins.	Lysine	126-132	bromodomain containing 4	Homo sapiens	34-38
20495683-1	2009	Bromodomain-containing protein 4 (Brd4) contains two tandem bromodomains (BD1 and BD2) that bind preferentially to acetylated lysine residues found in histones and nonhistone proteins.	Lysine	126-132	defensin beta 1	Homo sapiens	74-77
19109177-3	2009	Recent studies have revealed the essential role of Lys(55) in the collagenous region of MBL in the interaction with the MASPs and calreticulin (CRT).	Lysine	51-54	calreticulin	Homo sapiens	130-142
20495683-1	2009	Bromodomain-containing protein 4 (Brd4) contains two tandem bromodomains (BD1 and BD2) that bind preferentially to acetylated lysine residues found in histones and nonhistone proteins.	Lysine	126-132	defensin beta 4A	Homo sapiens	82-85
19109177-3	2009	Recent studies have revealed the essential role of Lys(55) in the collagenous region of MBL in the interaction with the MASPs and calreticulin (CRT).	Lysine	51-54	calreticulin	Homo sapiens	144-147
19109177-8	2009	Likewise, binding of each ficolin to CRT was inhibited by mutation of Lys to Ala or Glu, but not to Arg.	Lysine	70-73	calreticulin	Homo sapiens	37-40
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	49-52	calreticulin	Homo sapiens	127-130
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	24-27	calreticulin	Homo sapiens	127-130
19784597-4	2009	We recently identified propanoyl-lysine (propionyl-lysine, PRL) from the reaction of an n-3 FA and a lysine residue.	Lysine	33-39	prolactin	Homo sapiens	59-62
18753126-3	2009	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Lysine	91-97	tumor protein p53	Homo sapiens	134-137
18753126-3	2009	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Lysine	91-97	CREB binding protein	Homo sapiens	149-169
18820126-5	2009	Mutating this lysine in the full-length D(2) receptor to cysteine decreased the ability of the D(2) receptor to mediate agonist-induced arrestin 3 translocation to the membrane and decreased agonist-induced receptor internalization in human embryonic kidney 293 cells.	Lysine	14-20	arrestin 3	Homo sapiens	136-146
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	41-47	lysine (K)-specific demethylase 1A	Mus musculus	72-76
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	41-47	lysine (K)-specific demethylase 1A	Mus musculus	92-96
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	41-47	lysine (K)-specific demethylase 1A	Mus musculus	101-105
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	41-70
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	72-76
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	92-96
19098913-3	2009	Here we study the biological function of lysine-specific demethylase 1 (LSD1, also known as KDM1 and AOF2), which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	158-164	lysine (K)-specific demethylase 1A	Mus musculus	101-105
19565999-4	2009	The simulation process was guided in the main by cross-linking studies which proposed that Lys-13 of cytochrome c is paired with Asp-158 of COX.	Lysine	91-94	cytochrome c, somatic	Homo sapiens	101-113
18939950-4	2009	Using site-directed mutagenesis, we determined that single arginine/lysine residues within the cytoplasmic tail are sufficient to promote rapid Golgi targeting of Golgi-resident N-acetylglucosaminyltransferase I (GnTI) and alpha-mannosidase II (GMII).	Lysine	68-74	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	163-211
18939950-4	2009	Using site-directed mutagenesis, we determined that single arginine/lysine residues within the cytoplasmic tail are sufficient to promote rapid Golgi targeting of Golgi-resident N-acetylglucosaminyltransferase I (GnTI) and alpha-mannosidase II (GMII).	Lysine	68-74	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	213-217
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Lysine	82-85	prepronociceptin	Homo sapiens	39-44
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Lysine	82-85	prepronociceptin	Homo sapiens	90-95
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Lysine	82-85	prepronociceptin	Homo sapiens	90-95
19440361-10	2009	We showed that mutation of K99 clearly diminished USP25-dependent rescue of the specific substrate MyBPC1 from proteasome degradation, thereby supporting a new mechanistic model, in which USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains.	Lysine	299-305	myosin binding protein C1	Homo sapiens	99-105
19340297-3	2009	In particular, we show that CDKN1C is targeted by histone methyltransferase EZH2-mediated histone H3 lysine 27 trimethylation (H3K27me3), and can be strongly activated by inhibition of EZH2 in synergy with histone deacetylase inhibitor.	Lysine	101-107	cyclin dependent kinase inhibitor 1C	Homo sapiens	28-34
19340297-3	2009	In particular, we show that CDKN1C is targeted by histone methyltransferase EZH2-mediated histone H3 lysine 27 trimethylation (H3K27me3), and can be strongly activated by inhibition of EZH2 in synergy with histone deacetylase inhibitor.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	76-80
19340297-3	2009	In particular, we show that CDKN1C is targeted by histone methyltransferase EZH2-mediated histone H3 lysine 27 trimethylation (H3K27me3), and can be strongly activated by inhibition of EZH2 in synergy with histone deacetylase inhibitor.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	185-189
19372732-1	2009	The human PrP gene (PRNP) has two major polymorphic codons: 129 for methionine (M) or valine (V) and 219 for glutamate (E) or lysine (K).	Lysine	126-132	prion protein	Homo sapiens	10-13
19372732-1	2009	The human PrP gene (PRNP) has two major polymorphic codons: 129 for methionine (M) or valine (V) and 219 for glutamate (E) or lysine (K).	Lysine	126-132	prion protein	Homo sapiens	20-24
18990703-9	2008	Inhibition of Parp-1 activity (by 3-AB) reduced histone 3 lysine 9 acetylation and blocked Parp-1 binding to the BRCA2 promoter.	Lysine	58-64	poly(ADP-ribose) polymerase 1	Homo sapiens	14-20
18950638-1	2008	Transglutaminase 2 (TGase 2) catalyzes covalent isopeptide bond formation between glutamine and lysine residues.	Lysine	96-102	transglutaminase 2	Homo sapiens	0-18
18950638-1	2008	Transglutaminase 2 (TGase 2) catalyzes covalent isopeptide bond formation between glutamine and lysine residues.	Lysine	96-102	transglutaminase 2	Homo sapiens	20-27
19053766-4	2008	Ac-Trp-[Arg(24),Lys(25),Asp(31),Pro(34),Phe(35)]CGRP(8-37)-NH(2), 5 (K(i) = 0.06 nM) had the highest CGRP(1) receptor affinity.	Lysine	16-19	calcitonin related polypeptide alpha	Homo sapiens	48-52
18957409-1	2008	We show that the Saccharomyces cerevisiae ribosomal protein Rpl42ab (the identical product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.	Lysine	144-147	ribosomal 60S subunit protein L42A	Saccharomyces cerevisiae S288C	98-104
19111657-4	2008	Furthermore, addition of the FANCI protein enhances monoubiquitination and also restricts it to the in vivo substrate lysine residue on FANCD2.	Lysine	118-124	FA complementation group I	Homo sapiens	29-34
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	296-299	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	60-67
18957409-1	2008	We show that the Saccharomyces cerevisiae ribosomal protein Rpl42ab (the identical product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.	Lysine	155-158	ribosomal 60S subunit protein L42A	Saccharomyces cerevisiae S288C	98-104
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	296-299	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	221-228
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	296-299	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	60-67
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	49-56	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	60-67
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	284-287	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	60-67
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	284-287	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	221-228
18955483-4	2008	Our findings are (i) that at least 11 of the 167 lysines in IP(3)R1 can be ubiquitinated and that these are clustered in the regulatory domain and are found in surface regions, (ii) that at least approximately 40% of the IP(3)R1-associated ubiquitin is monoubiquitin, (iii) that both Lys(48) and Lys(63) linkages are abundant in attached ubiquitin chains, and (iv) that Lys(63) linkages accumulate most rapidly.	Lysine	296-299	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	221-228
18840606-1	2008	WDR5 is a component of the mixed lineage leukemia (MLL) complex, which methylates lysine 4 of histone H3, and was identified as a methylated Lys-4 histone H3-binding protein.	Lysine	82-88	WD repeat domain 5	Homo sapiens	0-4
18840612-0	2008	Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.	Lysine	63-69	tumor protein p53	Homo sapiens	43-46
18806826-1	2008	Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 methylation.	Lysine	155-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
18806826-1	2008	Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 methylation.	Lysine	155-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
18840612-3	2008	Recently, lysine methylation has been shown also to play a role in regulating non-histone proteins, including the tumor suppressor protein p53 (Huang, J., and Berger, S. L. (2008) Curr.	Lysine	10-16	tumor protein p53	Homo sapiens	139-142
18806826-5	2008	Here, we demonstrate that EZH2 mediates transcriptional silencing of the tumor suppressor gene E-cadherin by trimethylation of H3 lysine 27.	Lysine	130-136	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	26-30
18806826-5	2008	Here, we demonstrate that EZH2 mediates transcriptional silencing of the tumor suppressor gene E-cadherin by trimethylation of H3 lysine 27.	Lysine	130-136	cadherin 1	Homo sapiens	95-105
18840612-8	2008	Here, we identify a novel p53 species that is dimethylated at lysine 382 (p53K382me2) and show that the tandem Tudor domain of the DNA damage response mediator 53BP1 acts as an "effector" for this mark.	Lysine	62-68	tumor protein p53	Homo sapiens	26-29
18842586-7	2008	The presence of Wrnip1 into these heterogeneous subnuclear structures requires its ubiquitin-binding zinc finger (UBZ) domain, which is able to interact with different ubiquitin (Ub) signals, including mono-Ub and chains linked via lysine 48 and 63.	Lysine	232-238	WRN helicase interacting protein 1	Homo sapiens	16-22
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Lysine	94-97	immunglobulin heavy chain variable region	Homo sapiens	71-75
19061644-0	2008	Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.	Lysine	49-55	Lysine (K)-specific demethylase 4A	Drosophila melanogaster	91-96
19026640-3	2008	We showed that NFATc4 protein was predominantly ubiquitinated through the formation of Lysine 48-linked polyubiquitin chains, and this modification decreased NFATc4 protein levels and its transcriptional activity.	Lysine	87-93	nuclear factor of activated T cells 4	Homo sapiens	15-21
19026640-3	2008	We showed that NFATc4 protein was predominantly ubiquitinated through the formation of Lysine 48-linked polyubiquitin chains, and this modification decreased NFATc4 protein levels and its transcriptional activity.	Lysine	87-93	nuclear factor of activated T cells 4	Homo sapiens	158-164
19006282-0	2008	Coordination properties of lysine interacting with Co(I) and Co(II).	Lysine	27-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
19061644-0	2008	Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.	Lysine	49-55	Suppressor of variegation 205	Drosophila melanogaster	0-26
18680101-4	2008	A C-terminal D(Cys-Ser-Lys-Cys) cyclized peptide analog of insulin-like growth factor 1 (IGF1) was included to enable receptor-mediated cellular uptake.	Lysine	23-26	insulin like growth factor 1	Homo sapiens	59-87
18718449-0	2008	Itch self-polyubiquitylation occurs through lysine-63 linkages.	Lysine	44-50	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Lysine	21-24	insulin	Homo sapiens	121-128
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Lysine	61-64	insulin	Homo sapiens	121-128
19551948-9	2008	In this work we demonstrate dosing of Lucifer Yellow CH, LY, a charged fluorescent dye, into individual a7r5 vascular smooth muscle cells with a DMB.	Lysine	57-59	RT1 class II, locus DMb	Rattus norvegicus	145-148
19029828-4	2008	Lysines 46 and 112 are preferred sites of ubiquitin conjugation in p18(Ink4c), although substitution of these and other lysine residues with arginine, particularly in combination, triggers protein misfolding and accelerates p18(Ink4c) degradation.	Lysine	0-7	cyclin dependent kinase inhibitor 2C	Homo sapiens	67-70
18952440-1	2008	To elucidate the receptor-bound conformation of glucagon-like peptide-1 (GLP-1), a series of conformationally constrained GLP-1 analogues were synthesized by introducing lactam bridges between Lys(i) and Glu(i)(+4) to form alpha-helices at various positions.	Lysine	193-196	glucagon	Homo sapiens	48-71
18952440-1	2008	To elucidate the receptor-bound conformation of glucagon-like peptide-1 (GLP-1), a series of conformationally constrained GLP-1 analogues were synthesized by introducing lactam bridges between Lys(i) and Glu(i)(+4) to form alpha-helices at various positions.	Lysine	193-196	glucagon	Homo sapiens	73-78
18784356-4	2008	In wild-type S100A4 protein, the presence of the C-terminal lysine, residue 101, enhances the rate of association between S100A4 and NMMHC-IIA.	Lysine	60-66	myosin heavy chain 9	Homo sapiens	133-142
19029828-4	2008	Lysines 46 and 112 are preferred sites of ubiquitin conjugation in p18(Ink4c), although substitution of these and other lysine residues with arginine, particularly in combination, triggers protein misfolding and accelerates p18(Ink4c) degradation.	Lysine	0-7	cyclin dependent kinase inhibitor 2C	Homo sapiens	71-76
18723033-1	2008	EZH2 is the catalytic subunit of Polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that targets lysine-27 of histone H3.	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
18760861-7	2008	Chromatin immunoprecipitation (ChIP) assay experiments, after Tat treatment, revealed IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) in this region, presumably leading to chromatin remodeling.	Lysine	199-202	CREB binding protein	Homo sapiens	99-107
18628788-5	2008	Epigenetic analysis of the FMR1 gene demonstrated the lack of DNA methylation and a methylation pattern of lysines 4 and 27 on histone H3 similar to that of normal controls, in accordance with normal transcription levels and consistent with a euchromatic configuration.	Lysine	107-114	fragile X messenger ribonucleoprotein 1	Homo sapiens	27-31
19133078-3	2008	We found that Hsp90 is polymorphic for only two nonsynonymous changes in the coding region, both of which are deletions of a lysine residue.	Lysine	125-131	Heat shock protein 83	Drosophila melanogaster	14-19
18809684-3	2008	We reported that the TNFalpha transcription is disrupted in endotoxin tolerant THP-1 human promonocyte due to changes in transcription factor binding and enrichment with histone H3 dimethylated on lysine 9 (H3K9).	Lysine	197-203	tumor necrosis factor	Homo sapiens	21-29
18824541-7	2008	Mutagenesis of these two lysines abolished IRF-5 ubiquitination, nuclear translocation, and the IFNA promoter-inducing activity but not the IRF-5-TRAF6 interaction.	Lysine	25-32	IFN1@	Homo sapiens	96-100
18830798-9	2008	FLC chromatin from adf9-1 plants contained reduced levels of histone H3 lysine 4 trimethylation and lysine 9 and 14 acetylation, as well as increased nucleosome occupancy consistent with a less active chromatin state.	Lysine	72-78	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	0-3
18830798-9	2008	FLC chromatin from adf9-1 plants contained reduced levels of histone H3 lysine 4 trimethylation and lysine 9 and 14 acetylation, as well as increased nucleosome occupancy consistent with a less active chromatin state.	Lysine	72-78	actin depolymerizing factor 9	Arabidopsis thaliana	19-23
18830798-9	2008	FLC chromatin from adf9-1 plants contained reduced levels of histone H3 lysine 4 trimethylation and lysine 9 and 14 acetylation, as well as increased nucleosome occupancy consistent with a less active chromatin state.	Lysine	100-106	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	0-3
18830798-9	2008	FLC chromatin from adf9-1 plants contained reduced levels of histone H3 lysine 4 trimethylation and lysine 9 and 14 acetylation, as well as increased nucleosome occupancy consistent with a less active chromatin state.	Lysine	100-106	actin depolymerizing factor 9	Arabidopsis thaliana	19-23
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	WD repeat domain 5	Homo sapiens	123-127
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	WD repeat domain 5	Homo sapiens	129-148
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	151-156
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	158-190
18805448-7	2008	Two families of variants of GLT-1 were prepared with various lysine residues mutated to arginine.	Lysine	61-67	solute carrier family 1 member 2	Homo sapiens	28-33
18805448-8	2008	Analyses of these constructs indicated that redundant lysine residues in the carboxyl terminus were sufficient for the appearance of ubiquitinated product and degradation of GLT-1.	Lysine	54-60	solute carrier family 1 member 2	Homo sapiens	174-179
18807245-3	2008	In this paper, we describe a new [(3)H]labeled NOP antagonist, [Nphe(1),4"-(3)H-Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) ([(3)H]UFP-101).	Lysine	95-98	prepronociceptin	Homo sapiens	47-50
18807245-3	2008	In this paper, we describe a new [(3)H]labeled NOP antagonist, [Nphe(1),4"-(3)H-Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) ([(3)H]UFP-101).	Lysine	95-98	prepronociceptin	Homo sapiens	103-108
18694457-4	2008	Histone H3 lysine-27 di- and tri-methylation are paternally enriched at the imprinted loci Mez1, ZmFie1 and Nrp1.	Lysine	11-17	NAM-related protein 1	Zea mays	108-112
18809684-3	2008	We reported that the TNFalpha transcription is disrupted in endotoxin tolerant THP-1 human promonocyte due to changes in transcription factor binding and enrichment with histone H3 dimethylated on lysine 9 (H3K9).	Lysine	197-203	GLI family zinc finger 2	Homo sapiens	79-84
18761350-1	2008	Tissue transglutaminase (TG2) catalyzes the Ca(2+)-dependent posttranslational modification of proteins via formation of isopeptide bonds between their glutamine and lysine residues.	Lysine	166-172	transglutaminase 2	Homo sapiens	0-23
18620544-0	2008	Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-kappaB family member RelB.	Lysine	18-24	RELB proto-oncogene, NF-kB subunit	Homo sapiens	130-134
18620544-9	2008	Interestingly, basal RelB polyubiquitination depends neither on Lys(48) nor on Lys(63) conjugates, but might involve unconventional ubiquitin conjugates.	Lysine	64-67	RELB proto-oncogene, NF-kB subunit	Homo sapiens	21-25
18620544-9	2008	Interestingly, basal RelB polyubiquitination depends neither on Lys(48) nor on Lys(63) conjugates, but might involve unconventional ubiquitin conjugates.	Lysine	79-82	RELB proto-oncogene, NF-kB subunit	Homo sapiens	21-25
18620544-10	2008	Mapping of the ubiquitination target sites in RelB revealed the existence of various lysine residues, which serve as ubiquitination acceptors.	Lysine	85-91	RELB proto-oncogene, NF-kB subunit	Homo sapiens	46-50
18620544-11	2008	However, only the substitution of Lys(273/274) and Lys(305/308) significantly decreased the basal RelB activity and the ubiquitin-induced augmentation of the RelB activity.	Lysine	34-37	RELB proto-oncogene, NF-kB subunit	Homo sapiens	98-102
18620544-11	2008	However, only the substitution of Lys(273/274) and Lys(305/308) significantly decreased the basal RelB activity and the ubiquitin-induced augmentation of the RelB activity.	Lysine	34-37	RELB proto-oncogene, NF-kB subunit	Homo sapiens	158-162
18620544-11	2008	However, only the substitution of Lys(273/274) and Lys(305/308) significantly decreased the basal RelB activity and the ubiquitin-induced augmentation of the RelB activity.	Lysine	51-54	RELB proto-oncogene, NF-kB subunit	Homo sapiens	98-102
18620544-11	2008	However, only the substitution of Lys(273/274) and Lys(305/308) significantly decreased the basal RelB activity and the ubiquitin-induced augmentation of the RelB activity.	Lysine	51-54	RELB proto-oncogene, NF-kB subunit	Homo sapiens	158-162
18799463-6	2008	We found that: 1) histone H3 and H4 acetylation in the 15-LOX-1 promoter through KAT3B was critical to 15-LOX-1 transcriptional activation; 2) 15-LOX-1 transcription was activated independently from STAT-6; and 3) dimethyl-histone H3 lysine 9 (H3K9me2) demethylation in the 15-LOX-1 promoter via the histone lysine demethylase KDM3A was an early and specific histone modification and was necessary for activation of transcription.	Lysine	234-240	arachidonate 15-lipoxygenase	Homo sapiens	55-63
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	85-88	signal transducer and activator of transcription 3	Mus musculus	32-37
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	96-99	signal transducer and activator of transcription 3	Mus musculus	32-37
18977325-3	2008	ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias.	Lysine	43-49	lysine (K)-specific methyltransferase 2A	Mus musculus	103-106
18977328-4	2008	The molecular target of E6 in the NF-kappaB pathway is the CYLD lysine 63 (K63) deubiquitinase, a negative regulator of the NF-kappaB pathway.	Lysine	64-70	nuclear factor kappa B subunit 1	Homo sapiens	34-43
18977328-4	2008	The molecular target of E6 in the NF-kappaB pathway is the CYLD lysine 63 (K63) deubiquitinase, a negative regulator of the NF-kappaB pathway.	Lysine	64-70	nuclear factor kappa B subunit 1	Homo sapiens	124-133
18931660-3	2008	Here we provide a model to explain how trimethylated Lys 27 of histone 3 (H3K27me3), which is catalysed by the EZH2-containing Polycomb Repressive Complex 2 (PRC2), is maintained in proliferating cells.	Lysine	53-56	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	111-115
18768590-1	2008	WNK3, a member of the With No Lysine (K) family of protein serine/threonine kinases, was shown to regulate members of the SLC12A family of cation-chloride cotransporters and the renal outer medullary K+ channel ROMK and Cl(-) channel SLC26A9.	Lysine	30-36	WNK lysine deficient protein kinase 3 S homeolog	Xenopus laevis	0-4
18688016-3	2008	METHODS AND RESULTS: Mass spectrometry detected the presence of tryptophan, methionine, tyrosine, and lysine oxidation in apoAI recovered from human atheroma.	Lysine	102-108	apolipoprotein A1	Homo sapiens	122-127
18697203-7	2008	For the repression, acetylation of the C-terminal lysines of p53 is important, and both acetyl-K373p53 and methyl-K370p53 became bound to the promoter.	Lysine	50-57	tumor protein p53	Homo sapiens	61-64
18818087-1	2008	Nociceptin is an endogenous ligand that activates a G protein-coupled receptor ORL1 and contains two indispensable Arg-Lys (RK) dipeptide units at positions 8-9 and 12-13.	Lysine	119-122	prepronociceptin	Homo sapiens	0-10
18922786-6	2008	A study now demonstrates that MKP-1 is also acetylated on a key lysine residue following stimulation of TLRs.	Lysine	64-70	dual specificity phosphatase 1	Homo sapiens	30-35
18491415-0	2008	NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution.	Lysine	67-70	insulin	Homo sapiens	47-54
18675254-3	2008	Sumoylation of these lysine residues is associated with decreased levels of Abeta aggregates.	Lysine	21-27	amyloid beta precursor protein	Homo sapiens	76-81
18619497-6	2008	We further demonstrated that the sumoylation of CEBPD lysine 120 is also detectable in HepG2 cells, and this modification functions for binding of the recruits, HDAC1 and HDAC3.	Lysine	54-60	histone deacetylase 1	Homo sapiens	161-166
18667223-4	2008	In this work, matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry combined with enzymatic digestion analysis was used to identify the reactive lysine residues of horse spleen apoferritin when conjugated with N-hydroxysuccinimide reagents.	Lysine	180-186	ferritin heavy chain	Equus caballus	212-223
18513492-8	2008	Mutation or methylation of lysine 9, a mark well known for repression, abrogates histone methylation by MeCP2 but not by the p33ING2 complex.	Lysine	27-33	methyl-CpG binding protein 2	Homo sapiens	104-109
18667223-0	2008	Characterization of horse spleen apoferritin reactive lysines by MALDI-TOF mass spectrometry combined with enzymatic digestion.	Lysine	54-61	ferritin heavy chain	Equus caballus	33-44
18625888-4	2008	Interestingly, the relative level of H3 lysine 4 dimethylation to trimethylation at B-specific loci was high in multipotent CD34(+)CD38(lo) progenitors and decreased as they become actively transcribed in B-lineage cells.	Lysine	40-46	CD34 molecule	Homo sapiens	124-128
18655826-5	2008	We then delineated signal transduction from Erk2-mediated phosphorylation of RIP140 that enhanced its recruiting p300 for subsequent lysine acetylation, and demonstrated the kinetics of activation of this signal transduction pathway in differentiating adipocytes.	Lysine	133-139	mitogen-activated protein kinase 1	Homo sapiens	44-48
18655826-0	2008	Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation.	Lysine	14-20	mitogen-activated protein kinase 1	Homo sapiens	67-71
18655826-7	2008	These results demonstrate the signal transduction pathway, initiated from Erk2 activation for specific threonine phosphorylation, followed by p300 recruitment for lysine acetylation, which ultimately enhances the gene-repressive activity of RIP140 and its functional role in fat accumulation in differentiated adipocytes.	Lysine	163-169	mitogen-activated protein kinase 1	Homo sapiens	74-78
18721140-11	2008	These and other results suggested that the nonapeptide generated by matrilysin treatment might be anchored to the cell membrane, possibly by binding to intact annexin II, and interact with tPA via its C-terminal lysine.	Lysine	212-218	plasminogen activator, tissue type	Homo sapiens	189-192
18724273-0	2008	PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse.	Lysine	33-39	lysine methyltransferase 5A	Mus musculus	0-7
18852122-4	2008	Mutagenesis of these AR residues in helix 4, as well as mutation of lysine 720 in helix 3 (predicted to interact with the CoRNR box), markedly impaired AR recruitment of NCoR, indicating that N1 CoRNR box binding is being stabilized by these ionic interactions in the AR ligand-binding domain coactivator/corepressor binding site.	Lysine	68-74	androgen receptor	Homo sapiens	152-154
18797952-0	2008	Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification.	Lysine	0-6	transforming growth factor beta 1	Homo sapiens	35-42
18797952-4	2008	To fill this gap, we conducted a phylogenetic analysis of lysine conservation and context in TGFbeta and Wnt pathway receptors and signal transducers and suggest numerous high-probability candidates for posttranslational modification.	Lysine	58-64	transforming growth factor beta 1	Homo sapiens	93-100
18710948-0	2008	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.	Lysine	31-37	interferon regulatory factor 7	Homo sapiens	47-51
18710948-9	2008	Most important, we determine that the last three C-terminal lysine sites (positions 444, 446, and 452) of human IRF7 variant A are essential for activation of IRF7; these are the first such sites identified.	Lysine	60-66	interferon regulatory factor 7	Homo sapiens	112-116
18710948-9	2008	Most important, we determine that the last three C-terminal lysine sites (positions 444, 446, and 452) of human IRF7 variant A are essential for activation of IRF7; these are the first such sites identified.	Lysine	60-66	interferon regulatory factor 7	Homo sapiens	159-163
18662994-5	2008	Sug1 binds to acetylated histone H3 and, in the absence of Sug1, histone H3 acetylation is dramatically decreased at the proximal promoter, with a preferential loss of acetylation at H3 lysine 18.	Lysine	186-192	proteasome 26S subunit, ATPase 5	Homo sapiens	0-4
18846226-0	2008	Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II.	Lysine	39-45	kismet	Drosophila melanogaster	11-17
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	46-49	transforming growth factor beta 1	Homo sapiens	14-22
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	87-90	transforming growth factor beta 1	Homo sapiens	14-22
18846226-7	2008	The presence of two chromodomains in KIS-L suggested that its recruitment or function might be regulated by the methylation of histone H3 lysine 4 by the trithorax group proteins ASH1 and TRX.	Lysine	138-144	kismet	Drosophila melanogaster	37-42
18755837-1	2008	We recently showed that the gamma-subunit of Kluyveromyces lactis killer toxin (gamma-toxin) is a tRNA endonuclease that cleaves tRNA(mcm5s2UUC Glu), tRNA(mcm5s2UUU Lys), and tRNA(mcm5s2UUG Gln) 3" of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U).	Lysine	165-168	trnT	Kluyveromyces lactis	98-102
18755837-1	2008	We recently showed that the gamma-subunit of Kluyveromyces lactis killer toxin (gamma-toxin) is a tRNA endonuclease that cleaves tRNA(mcm5s2UUC Glu), tRNA(mcm5s2UUU Lys), and tRNA(mcm5s2UUG Gln) 3" of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U).	Lysine	165-168	trnT	Kluyveromyces lactis	129-133
18755837-1	2008	We recently showed that the gamma-subunit of Kluyveromyces lactis killer toxin (gamma-toxin) is a tRNA endonuclease that cleaves tRNA(mcm5s2UUC Glu), tRNA(mcm5s2UUU Lys), and tRNA(mcm5s2UUG Gln) 3" of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U).	Lysine	165-168	trnT	Kluyveromyces lactis	129-133
18755837-1	2008	We recently showed that the gamma-subunit of Kluyveromyces lactis killer toxin (gamma-toxin) is a tRNA endonuclease that cleaves tRNA(mcm5s2UUC Glu), tRNA(mcm5s2UUU Lys), and tRNA(mcm5s2UUG Gln) 3" of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U).	Lysine	165-168	trnT	Kluyveromyces lactis	129-133
18650421-9	2008	Microarray profiling revealed that, in TNF-alpha-stimulated monocytes, the induction of 25% NF-kappaB downstream genes, including the histone H3-lysine 27 demethylase JMJD3, was attenuated by SET7/9 depletion.	Lysine	145-151	tumor necrosis factor	Mus musculus	39-48
18706439-2	2008	We discovered a novel C312A transversion in exon 2 of the human GUCA1A gene, replacing Asn-104 (N104) in GCAP1 with Lys (K), in two affected members of a family with dominant cone dystrophy.	Lysine	116-119	guanylate cyclase activator 1A	Homo sapiens	64-70
18706439-2	2008	We discovered a novel C312A transversion in exon 2 of the human GUCA1A gene, replacing Asn-104 (N104) in GCAP1 with Lys (K), in two affected members of a family with dominant cone dystrophy.	Lysine	116-119	guanylate cyclase activator 1A	Homo sapiens	105-110
18650434-4	2008	Examination of the S100A1-RyRP12 complex revealed residues of the helical RyRP12 peptide (Lys-3616, Trp-3620, Lys-3622, Leu-3623, Leu-3624, and Lys-3626) that are involved in favorable hydrophobic and electrostatic interactions with Ca(2+)-S100A1.	Lysine	90-93	S100 calcium binding protein A1	Homo sapiens	19-25
18818304-7	2008	Mutation of Bax at K128, which corresponds to a conserved lysine in Kv1.3-inhibiting toxins, abrogated its effects on both Kv1.3 and mitochondria.	Lysine	58-64	BCL2 associated X, apoptosis regulator	Homo sapiens	12-15
18650421-9	2008	Microarray profiling revealed that, in TNF-alpha-stimulated monocytes, the induction of 25% NF-kappaB downstream genes, including the histone H3-lysine 27 demethylase JMJD3, was attenuated by SET7/9 depletion.	Lysine	145-151	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-101
18688044-4	2008	Chromatin immunoprecipitation assays showed that levels of histone H3 lysine 4 dimethylation (H3K4me2), a key chromatin mark associated with active gene expression, were significantly elevated at the promoters of the inflammatory genes monocyte chemoattractant protein-1 and interleukin-6 in db/db VSMCs relative to db/+ cells.	Lysine	70-76	interleukin 6	Mus musculus	275-288
18791070-3	2008	Here, we show that the hERG1 polymorphism at codon 897, which is read as a Thr instead of a Lys, creates a phosphorylation site for the Akt protein kinase on the Kv11.1 channel protein.	Lysine	92-95	AKT serine/threonine kinase 1	Homo sapiens	136-139
18758443-2	2008	The Zn(2+)-dependent DUBs AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving Lys 63-linked polyubiquitin chains from internalized receptors.	Lysine	98-101	STAM binding protein	Homo sapiens	26-30
18758443-2	2008	The Zn(2+)-dependent DUBs AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving Lys 63-linked polyubiquitin chains from internalized receptors.	Lysine	98-101	STAM binding protein like 1	Homo sapiens	35-42
18758443-3	2008	Here we report the crystal structures of the human AMSH-LP DUB domain alone and in complex with a Lys 63-linked di-ubiquitin at 1.2 A and 1.6 A resolutions, respectively.	Lysine	98-101	STAM binding protein like 1	Homo sapiens	51-58
18758443-7	2008	This is the first reported structure of a DUB in complex with an isopeptide-linked ubiquitin chain, which reveals the mechanism for Lys 63-linkage-specific deubiquitination by AMSH family members.	Lysine	132-135	STAM binding protein	Homo sapiens	176-180
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Lysine	117-120	tumor protein p53	Homo sapiens	75-78
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Lysine	162-165	tumor protein p53	Homo sapiens	75-78
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	tumor protein p53	Homo sapiens	97-100
18777595-8	2008	LY 294002 significantly reduced the contents of PI 3-K and p-Akt.	Lysine	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
18787701-1	2008	Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79).	Lysine	75-81	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
18581285-7	2008	Lysine methylation enhances or suppresses p53 transcriptional activity depending on the methylation site.	Lysine	0-6	tumor protein p53	Homo sapiens	42-45
18176935-0	2008	Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.	Lysine	26-32	H3 clustered histone 14	Homo sapiens	47-49
18469044-7	2008	1 showed that the SID of Lys in DDGS from MN2 (72.8%) was greater (P &lt; 0.01) than in DDGS from MN1 (66.8%), IL1 (66.8%), and KY (65.8%) but not different from IL2 (70.1%).	Lysine	25-28	IL2	Sus scrofa	162-165
18564219-3	2008	It is well established that in the presence of thrombin-activated factor XIII (FXIIIa), alpha2AP becomes covalently ligated to the distal alpha chains of fibrin or fibrinogen at lysine 303 (two potential sites per molecule).	Lysine	178-184	fibrinogen beta chain	Homo sapiens	164-174
18176935-1	2008	Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing.	Lysine	15-21	H3 clustered histone 14	Homo sapiens	36-38
18176935-1	2008	Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing.	Lysine	15-21	H3 clustered histone 14	Homo sapiens	40-45
18176935-1	2008	Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark that mediates gene silencing.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
18719106-6	2008	HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-linked polyubiquitination of PCNA.	Lysine	77-83	SNF2 histone linker PHD RING helicase	Homo sapiens	11-16
18701950-1	2008	Two structural changes of poly-L-lysine have been studied by various spectroscopic techniques; one is a structural change of a random coil sample in solution to a mixture of alpha-helix and beta-sheet during rapid freezing in the lyophilizing process, and the other is a pressure-induced structural change from an alpha-helix to a beta-sheet structure for a lyophilized sample.	Lysine	26-39	amyloid beta precursor protein	Homo sapiens	329-335
18579533-2	2008	Nkx2.5 was modified by SUMO on its 51st amino acid, a lysine residue conserved across species but absent in other nk-2 members.	Lysine	54-60	NK2 homeobox 5	Homo sapiens	0-6
18579533-3	2008	Conversion of this lysine to an arginine (K51R) substantially reduced Nkx2.5 DNA binding and also its transcriptional activity.	Lysine	19-25	NK2 homeobox 5	Homo sapiens	70-76
18701507-0	2008	Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.	Lysine	34-40	PYD and CARD domain containing	Homo sapiens	78-82
18724933-1	2008	The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold.	Lysine	121-127	male-specific lethal 1	Drosophila melanogaster	15-18
18701507-0	2008	Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.	Lysine	34-40	PYD and CARD domain containing	Homo sapiens	83-86
18701507-3	2008	Here, we establish an important role for histone H4 lysine 16 acetylation (H4K16Ac) and the histone acetyltransferase hMOF in the regulation of TMS1/ASC, a proapoptotic gene that undergoes epigenetic silencing in human cancers.	Lysine	52-58	PYD and CARD domain containing	Homo sapiens	144-148
18701507-3	2008	Here, we establish an important role for histone H4 lysine 16 acetylation (H4K16Ac) and the histone acetyltransferase hMOF in the regulation of TMS1/ASC, a proapoptotic gene that undergoes epigenetic silencing in human cancers.	Lysine	52-58	PYD and CARD domain containing	Homo sapiens	149-152
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	15-18	prepronociceptin	Homo sapiens	51-56
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	15-18	prepronociceptin	Homo sapiens	246-249
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	43-46	prepronociceptin	Homo sapiens	51-56
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	43-46	prepronociceptin	Homo sapiens	214-224
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	43-46	prepronociceptin	Homo sapiens	225-236
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	43-46	prepronociceptin	Homo sapiens	246-249
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	15-18	prepronociceptin	Homo sapiens	214-224
18624395-2	2008	cyclo[D-Asp(7),Lys(10)]- and cyclo[Asp (6),Lys(10)]N/OFQ(1-13)NH2 exhibit high affinity (Ki = 0.27 and 0.34 nM, respectively) and high potency in the GTPgammaS assay (EC 50 = 1.6 and 4.1 nM, respectively) at human nociceptin/orphanin FQ peptide (NOP) receptors.	Lysine	15-18	prepronociceptin	Homo sapiens	225-236
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Lysine	58-64	RELB proto-oncogene, NF-kB subunit	Homo sapiens	18-22
18550520-3	2008	We have tested this hypothesis by performing facial axotomies on cytochrome c knock-in mice containing a point mutation in the genomic locus of cytochrome c resulting in a lysine to alanine conversion at position 72 of the protein.	Lysine	172-178	cytochrome c, somatic	Homo sapiens	144-156
18439917-4	2008	Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter.	Lysine	124-130	tumor necrosis factor	Homo sapiens	54-62
18439917-4	2008	Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter.	Lysine	124-130	mitogen-activated protein kinase kinase 4	Homo sapiens	77-81
18439917-4	2008	Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter.	Lysine	124-130	mitogen-activated protein kinase 8	Homo sapiens	82-86
18439917-4	2008	Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter.	Lysine	124-130	tumor necrosis factor	Homo sapiens	157-165
18637669-8	2008	PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator.	Lysine	178-184	folate hydrolase 1	Homo sapiens	0-4
18637669-8	2008	PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator.	Lysine	178-184	folate hydrolase 1	Homo sapiens	76-80
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Lysine	58-64	RELB proto-oncogene, NF-kB subunit	Homo sapiens	103-107
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Lysine	58-64	karyopherin subunit alpha 1	Homo sapiens	111-126
18455220-6	2008	RESULTS: Cytokines with positively charged beads caused greater eosinophil peroxidase release (lysine coated, 44.2 nmol/L; compound 48/80, 40.0 nmol/L; or EDN coated, 49.1 nmol/L) than cytokines alone (14.9 nmol/L).	Lysine	95-101	eosinophil peroxidase	Homo sapiens	64-85
18676811-3	2008	The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that deacetylation of the histone variant Htz1p at Lys 14 is mediated by Hda1p.	Lysine	175-178	histone H2AZ	Saccharomyces cerevisiae S288C	166-171
18519590-6	2008	Chromatin immunoprecipitation assays demonstrated that Snail1 increases the binding of Suz12 to the CDH1 promoter and the trimethylation of lysine 27 in histone H3.	Lysine	140-146	snail family transcriptional repressor 1	Homo sapiens	55-61
18507738-4	2008	p39 and p35 contain localization motifs, such as a second Gly for myristoylation and Lys clusters in the N-terminal p10 region.	Lysine	85-88	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	0-3
18507738-4	2008	p39 and p35 contain localization motifs, such as a second Gly for myristoylation and Lys clusters in the N-terminal p10 region.	Lysine	85-88	S100 calcium binding protein A10	Homo sapiens	116-119
18507738-8	2008	Plasma membrane targeting depends on the amino acid sequence containing the Lys-cluster in the N-terminal p10 region.	Lysine	76-79	S100 calcium binding protein A10	Homo sapiens	106-109
18613717-5	2008	The polyubiquitin chains conjugated to WRNIP1 are linked through lysines 11, 48, and 63.	Lysine	65-72	WRN helicase interacting protein 1	Homo sapiens	39-45
18480409-3	2008	Substitution of all lysine residues in the intracellular part of FGFR1 resulted in inactivation of the tyrosine kinase domain of the receptor.	Lysine	20-26	fibroblast growth factor receptor 1	Homo sapiens	65-70
18480409-4	2008	However, several multilysine FGFR1 mutants, where up to 26 of 29 lysines in the intracellular part of the receptor were mutated, retained tyrosine kinase activity.	Lysine	65-72	fibroblast growth factor receptor 1	Homo sapiens	29-34
18654986-5	2008	In MS analysis of tryptic peptides derived from the equally mixed three cell populations, the lysine-containing peptides originated from two LPS-stimulated cell populations can be clearly distinguished by their different mass shifts from the unstimulated and unlabeled counterpart.	Lysine	94-100	toll-like receptor 4	Mus musculus	141-144
18456371-3	2008	NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys(129)-Arg(130) and Arg(145)-Arg(146) sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated).	Lysine	75-78	pro-melanin concentrating hormone	Homo sapiens	38-41
18550230-3	2008	We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to generate potent immune responses in mice.	Lysine	101-114	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	83-92
18644123-0	2008	Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS.	Lysine	74-80	poly(ADP-ribose) polymerase 2	Homo sapiens	51-57
18644123-5	2008	In contrast, lysine 36, which is located within a predicted classical monopartite NLS, was required for PARP-2 nuclear localization.	Lysine	13-19	poly(ADP-ribose) polymerase 2	Homo sapiens	104-110
18644123-7	2008	CONCLUSION: Our results provide strong evidence that lysine 36 of PARP-2 is a critical residue for proper nuclear targeting of PARP-2 and consequently for the execution of its biological functions.	Lysine	53-59	poly(ADP-ribose) polymerase 2	Homo sapiens	66-72
18644123-7	2008	CONCLUSION: Our results provide strong evidence that lysine 36 of PARP-2 is a critical residue for proper nuclear targeting of PARP-2 and consequently for the execution of its biological functions.	Lysine	53-59	poly(ADP-ribose) polymerase 2	Homo sapiens	127-133
18524409-3	2008	In one vector lysine residues were dispersed (KHKHKHKHKK)(6)-FGF2, whereas in the other they were in clusters (KKKHHHHKKK)(6)-FGF2.	Lysine	14-20	fibroblast growth factor 2	Homo sapiens	61-65
18450745-0	2008	Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.	Lysine	73-79	chromodomain Y-linked 1B	Homo sapiens	19-44
18450745-9	2008	The CDY chromodomain exhibits discriminatory binding to lysine-methylated ARK(S/T) motifs, whereas the CDYL2 chromodomain binds with comparable strength to multiple ARK(S/T) motifs.	Lysine	56-62	chromodomain Y-linked 1B	Homo sapiens	4-7
21828684-3	2008	The electrostatic interaction between positively charged L-lysine capped gold nanoparticles and negatively charged human serum albumin at physiological pH led to the assembly of the gold nanoparticles into hollow spheres.	Lysine	57-65	albumin	Homo sapiens	127-134
18435604-6	2008	Both beta-arrestin 2 mutants displayed limited capacity to co-immunoprecipitate ERK1/2 and further spot-immobilized peptide arrays indicated each of Lys(285), Arg(286) and particularly Lys(295) to be important for this interaction.	Lysine	149-152	arrestin beta 2	Homo sapiens	5-20
18492769-8	2008	Glucagon also, like insulin, enhanced the phosphorylation of Akt/PKB, a downstream target of PI3K, and these effects were also abolished by LY-294002.	Lysine	140-142	AKT serine/threonine kinase 1	Rattus norvegicus	61-68
18435604-6	2008	Both beta-arrestin 2 mutants displayed limited capacity to co-immunoprecipitate ERK1/2 and further spot-immobilized peptide arrays indicated each of Lys(285), Arg(286) and particularly Lys(295) to be important for this interaction.	Lysine	185-188	arrestin beta 2	Homo sapiens	5-20
18584348-0	2008	Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines.	Lysine	12-15	cadherin 1	Homo sapiens	81-91
18406180-7	2008	In addition to phosphorylation, C/EBP alpha is modified, post-translationally by a small ubiquitin-related modifier (SUMO) at a lysine residue (K159), which lies within the growth inhibitory region of the C/EBP alpha protein.	Lysine	128-134	CCAAT enhancer binding protein alpha	Homo sapiens	32-43
18406180-7	2008	In addition to phosphorylation, C/EBP alpha is modified, post-translationally by a small ubiquitin-related modifier (SUMO) at a lysine residue (K159), which lies within the growth inhibitory region of the C/EBP alpha protein.	Lysine	128-134	CCAAT enhancer binding protein alpha	Homo sapiens	205-216
18502945-4	2008	EZH2, as a protein of the PcG complex, PRC2, has an important role in the propagation of epigenetic memory through deposition of the repressive mark, histone H3, lysine 27, tri-methylation (H3K27me3).	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
18418832-2	2008	The dipeptide mimetic, which respectively displayed the side chains of tryptophan and lysine at the nitrogen and O6 atoms of the iminosugar scaffold is a ligand (K(i)=3.2 microM) for the human somatostatin receptor subtype 4 (hSSTR4) but has lower affinity (K(i)&gt;100 microM) for hSSTR5.	Lysine	86-92	somatostatin receptor 4	Homo sapiens	226-232
18495509-11	2008	These results provide insight into the role of the cCAT-2 gene and its regulation of lysine and arginine utilization in aves.	Lysine	85-91	solute carrier family 7 member 2	Gallus gallus	51-57
18381652-0	2008	PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster.	Lysine	89-96	solute carrier family 1 member 2	Rattus norvegicus	33-37
18381652-4	2008	In this article, we show that this internalization process is dependent on the ubiquitylation of lysine residues located in the C-terminal tail of GLT1.	Lysine	97-103	solute carrier family 1 member 2	Rattus norvegicus	147-151
18381652-7	2008	The elimination of lysines from the C-terminus of the transporter (lysines 497, 517, 526, 550, 558, 570, and 573) blocked GLT1 ubiquitylation and endocytosis.	Lysine	19-26	solute carrier family 1 member 2	Rattus norvegicus	122-126
18381652-7	2008	The elimination of lysines from the C-terminus of the transporter (lysines 497, 517, 526, 550, 558, 570, and 573) blocked GLT1 ubiquitylation and endocytosis.	Lysine	67-74	solute carrier family 1 member 2	Rattus norvegicus	122-126
18381652-8	2008	However, reintroduction of lysine 517 alone into this mutant was sufficient to restore PMA dependent ubiquitylation and internalization of GLT1.	Lysine	27-33	solute carrier family 1 member 2	Rattus norvegicus	139-143
18388150-0	2008	Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome.	Lysine	37-44	estrogen receptor 1	Homo sapiens	0-23
18381652-10	2008	These data suggest that the activation of PKC induces the ubiquitylation of these C-terminal lysine residues in GLT1 and that this modification mediates the interaction of the transporter with the endocytic machinery.	Lysine	93-99	solute carrier family 1 member 2	Rattus norvegicus	112-116
18713402-4	2008	ACI1 encodes a nuclear protein with a lysine-rich domain and a C-terminal serine-rich domain.	Lysine	38-44	ALC-interacting protein 1	Arabidopsis thaliana	0-4
23055876-5	2008	RESULTS: THE FOLLOWING DRUGS WERE DEEMED COMPATIBLE WITH IBUPROFEN LYSINE: ceftazidime, epinephrine, furosemide, heparin lock flush, diluted insulin, morphine sulfate, phenobarbital, potassium chloride, and sodium bicarbonate.	Lysine	67-73	insulin	Homo sapiens	141-148
18397234-4	2008	METHODS: We studied a total of nine polymorphisms of the IRF-7 gene including SNP1047A/G (Lys/Glu) and SNP2157A/G (Gln/Arg) using the Taqman allelic discrimination and sequencing techniques in 406 Japanese patients with chronic HCV infection.	Lysine	90-93	interferon regulatory factor 7	Homo sapiens	57-62
18562671-2	2008	Dot1 methylates lysine 79 of histone H3.	Lysine	16-22	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
18388150-2	2008	Dynamic interactions between ERalpha and the protein degradation machinery facilitate the down-regulation process by targeting receptor lysine residues for polyubiquitination.	Lysine	136-142	estrogen receptor 1	Homo sapiens	29-36
18388150-4	2008	Two receptor lysines, K302 and K303, located in the hinge-region of ERalpha, serve multiple regulatory functions, and we examined whether these might also regulate receptor polyubiquitination, turnover, and receptor-protein interactions.	Lysine	13-20	estrogen receptor 1	Homo sapiens	68-75
18388150-8	2008	Furthermore, ERalpha-AA was resistant to ICI-induced polyubiquitination, suggesting that these lysines are polyubiquitinated in response to the antiestrogen and demonstrate a novel role for these two lysines in the mechanism of action of ICI-induced receptor down-regulation.	Lysine	95-102	estrogen receptor 1	Homo sapiens	13-20
18388150-8	2008	Furthermore, ERalpha-AA was resistant to ICI-induced polyubiquitination, suggesting that these lysines are polyubiquitinated in response to the antiestrogen and demonstrate a novel role for these two lysines in the mechanism of action of ICI-induced receptor down-regulation.	Lysine	200-207	estrogen receptor 1	Homo sapiens	13-20
18439419-2	2008	In this study, we found that the treatment with a p44/42 MAPK inhibitor, PD98059, induced di-methylation at lysine 9 on the upstream/transcriptional regions of the GLUT5 gene.	Lysine	108-114	solute carrier family 2 member 5	Homo sapiens	164-169
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-31
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	CREB binding protein	Homo sapiens	87-107
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	CREB binding protein	Homo sapiens	109-112
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	CREB binding protein	Homo sapiens	222-225
18439419-4	2008	These results suggest that the histone H3 di-methylation at lysine 9, as well as acetylation at lysine 9/14, may be indispensable for coordinated induction of the GLUT5 gene by p44/42 MAP kinase inhibition and the glucocorticoid hormone.	Lysine	60-66	solute carrier family 2 member 5	Homo sapiens	163-168
18439419-4	2008	These results suggest that the histone H3 di-methylation at lysine 9, as well as acetylation at lysine 9/14, may be indispensable for coordinated induction of the GLUT5 gene by p44/42 MAP kinase inhibition and the glucocorticoid hormone.	Lysine	96-102	solute carrier family 2 member 5	Homo sapiens	163-168
18523266-7	2008	The protein stability, Ser(392) phosphorylation and Lys(373)/Lys(382) acetylation of p53 were enhanced by MG132.	Lysine	52-55	tumor protein p53	Homo sapiens	85-88
18588675-3	2008	The two best-characterized PcG complexes are the PcG repressive complex 1 (PRC1) and 2 (PRC2) that respectively possess histone 2A lysine 119 E3 ubiquitin ligase and histone 3 lysine 27 methyltransferase activities.	Lysine	131-137	fascetto	Drosophila melanogaster	75-79
18512960-13	2008	The average value of the experimental DeltaG(E)() for the six lysine methyl transfer reactions catalyzed by vSET, LSMT, and SET7/9 with p53 as a substrate is 22.1 +/- 1.0 kcal/mol, and the computed average (DeltaG(C)()) is 22.2 +/- 0.8 kcal/mol.	Lysine	62-68	tumor protein p53	Homo sapiens	136-139
18559531-3	2008	Knockdown of histone deacetylase (HDAC) 6, which deacetylates lysine residues in hsp90, induces reversible hyperacetylation and attenuates ATP binding and chaperone function of hsp90.	Lysine	62-68	histone deacetylase 6	Homo sapiens	13-41
18559531-4	2008	Here, using mass spectrometry, we identified seven lysine residues in hsp90alpha that are hyperacetylated after treatment of eukaryotic cells with a pan-HDAC inhibitor that also inhibits HDAC6.	Lysine	51-57	histone deacetylase 6	Homo sapiens	187-192
18523251-0	2008	Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.	Lysine	0-6	CD4 molecule	Homo sapiens	83-86
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Lysine	4-10	S100 calcium binding protein B	Homo sapiens	173-176
18523266-7	2008	The protein stability, Ser(392) phosphorylation and Lys(373)/Lys(382) acetylation of p53 were enhanced by MG132.	Lysine	61-64	tumor protein p53	Homo sapiens	85-88
18523251-9	2008	Lysine-free Nef mutant reintroduced with lysine 144 (DeltaK10 + K144) was shown active in CD4 down-regulation.	Lysine	0-6	S100 calcium binding protein B	Homo sapiens	12-15
18462753-7	2008	These data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2"-phosphoryl moiety of NADP(+) and a threonine/lysine pair on ALDH(C).	Lysine	173-179	aldehyde dehydrogenase family protein	Paraburkholderia xenovorans LB400	188-192
18523251-9	2008	Lysine-free Nef mutant reintroduced with lysine 144 (DeltaK10 + K144) was shown active in CD4 down-regulation.	Lysine	0-6	CD4 molecule	Homo sapiens	90-93
18523251-9	2008	Lysine-free Nef mutant reintroduced with lysine 144 (DeltaK10 + K144) was shown active in CD4 down-regulation.	Lysine	41-47	S100 calcium binding protein B	Homo sapiens	12-15
18523251-9	2008	Lysine-free Nef mutant reintroduced with lysine 144 (DeltaK10 + K144) was shown active in CD4 down-regulation.	Lysine	41-47	CD4 molecule	Homo sapiens	90-93
18523251-10	2008	These data suggest that ubiquitination of Nef, particularly diubiquitination of the lysine 144, is necessary for Nef-mediated CD4 down-regulation.	Lysine	84-90	S100 calcium binding protein B	Homo sapiens	42-45
18523251-10	2008	These data suggest that ubiquitination of Nef, particularly diubiquitination of the lysine 144, is necessary for Nef-mediated CD4 down-regulation.	Lysine	84-90	S100 calcium binding protein B	Homo sapiens	113-116
18523251-10	2008	These data suggest that ubiquitination of Nef, particularly diubiquitination of the lysine 144, is necessary for Nef-mediated CD4 down-regulation.	Lysine	84-90	CD4 molecule	Homo sapiens	126-129
18449190-3	2008	One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4).	Lysine	63-69	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	248-252
18449190-3	2008	One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4).	Lysine	96-102	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	248-252
20641421-4	2004	VIP (HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2) is a hydrophobic, basic peptide that contains three lysine residues (1520, and 21, ), two arginine residues (12 and 14, ), two tyrosine residues (10 and 22, ), an essential histidine residue at the N terminus, and an amidated C-terminus (10).	Lysine	91-97	vasoactive intestinal peptide	Homo sapiens	0-3
18449190-3	2008	One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4).	Lysine	96-102	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	248-252
18519690-8	2008	This SS18-SSX binding correlates with trimethylation of Lys(27) of histone H3 (H3K27-M3) and recruitment of polycomb group proteins to this promoter.	Lysine	56-59	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	5-9
18457426-1	2008	Structural and mutagenesis data have indicated that the 220-loop of thrombin is stabilized by a salt-bridge between Glu-217 and Lys-224, thereby facilitating the octahedral coordination of Na (+) with contributions from two carbonyl O atoms of Arg-221a and Lys-224.	Lysine	128-131	coagulation factor II, thrombin	Homo sapiens	68-76
18457426-1	2008	Structural and mutagenesis data have indicated that the 220-loop of thrombin is stabilized by a salt-bridge between Glu-217 and Lys-224, thereby facilitating the octahedral coordination of Na (+) with contributions from two carbonyl O atoms of Arg-221a and Lys-224.	Lysine	257-260	coagulation factor II, thrombin	Homo sapiens	68-76
18457426-8	2008	These results suggest that, similar to thrombin, an ionic interaction between Glu-217 and Lys-224 stabilizes the 220-loop of fXa for binding Na (+).	Lysine	90-93	coagulation factor II, thrombin	Homo sapiens	39-47
26621236-14	2008	A case study of the catalytic lysine residue in 2-deoxyribose-5-phosphate aldolase (DERA) is also presented.	Lysine	30-36	deoxyribose-phosphate aldolase	Homo sapiens	48-82
26621236-14	2008	A case study of the catalytic lysine residue in 2-deoxyribose-5-phosphate aldolase (DERA) is also presented.	Lysine	30-36	deoxyribose-phosphate aldolase	Homo sapiens	84-88
18991196-3	2008	In contrast, corticotropin (ACTH) treatment was associated with increased alanine and phenylalanine, and decreased taurine compared to controls and untreated OMS, and increased glutamine, lysine, ornithine, and tyrosine compared to untreated OMS.	Lysine	188-194	proopiomelanocortin	Homo sapiens	28-32
18364376-9	2008	RESULTS: Addition of calcitonin screening to current American Thyroid Association guidelines for the evaluation of thyroid nodules would cost $11,793 per LYS ($10,941-$12,646).	Lysine	154-157	calcitonin related polypeptide alpha	Homo sapiens	21-31
18337589-6	2008	S246 GR phosphorylation by JNK facilitated subsequent GR sumoylation at lysines 297 and 313.	Lysine	72-79	nuclear receptor subfamily 3 group C member 1	Homo sapiens	5-7
18337589-6	2008	S246 GR phosphorylation by JNK facilitated subsequent GR sumoylation at lysines 297 and 313.	Lysine	72-79	mitogen-activated protein kinase 8	Homo sapiens	27-30
18337589-6	2008	S246 GR phosphorylation by JNK facilitated subsequent GR sumoylation at lysines 297 and 313.	Lysine	72-79	nuclear receptor subfamily 3 group C member 1	Homo sapiens	54-56
18488044-4	2008	A comprehensive mutation-based structure-function analysis correlating transcriptional repression, ubiquitin-conjugating enzyme 9 (UBC9) binding and SUMOylation shows that the PHD finger and the bromodomain of KAP1 cooperate as one functional unit to facilitate lysine SUMOylation, which is required for KAP1 co-repressor activity in gene silencing.	Lysine	262-268	tripartite motif containing 28	Homo sapiens	210-214
18391024-1	2008	Dot1 methylates histone H3 lysine 79 (H3K79) on the nucleosome core and is involved in Sir protein-mediated silencing.	Lysine	27-33	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	0-4
18991196-5	2008	The ACTH dose-association was most apparent for alanine and phosphoethanolamine, but lysine and ornithine were also higher in the high-dose ACTH group.	Lysine	85-91	proopiomelanocortin	Homo sapiens	140-144
18332147-9	2008	By mutational analysis, we demonstrate, for the first time, that nuclear translocation occurs via nuclear localization signal (NLS) within residues Arg(471)-Lys(472) in CRMP2 sequence.	Lysine	157-160	dihydropyrimidinase like 2	Homo sapiens	169-174
18400224-2	2008	A novel breakdown product arising from the hydrolysis of water buffalo beta-casein, originated by the presence of a plasmin-sensitive Lys bond at position 68 was identified, which was not present in bovine beta-casein.	Lysine	134-137	beta-casein	Bubalus bubalis	71-82
18467490-6	2008	Chromatin immunoprecipitation (ChIP) experiments indicated that histone 3 lysine 9 (H3K9) methylation status was changed in elf6 and ref6 mutants, consistent with recent findings that many Jmj proteins are histone demethylases.	Lysine	74-80	Zinc finger (C2H2 type) family protein / transcription factor jumonji (jmj) family protein	Arabidopsis thaliana	124-128
18483254-4	2008	Ik1 decreases methylation and increases acetylation of histone H3 (Lys(9)) at the LDL-R promoter.	Lysine	67-70	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	0-3
18406507-11	2008	Acetylation of p53 at Lys 382 was not affected by these inhibitors, suggesting that acetylation stabilizes p53 in response to DNA damage.	Lysine	22-25	tumor protein p53	Homo sapiens	15-18
18406507-7	2008	Activation of p53 was evidenced by its phosphorylation at serine 15 (Ser15) and acetylation at lysine 382 (Lys382).	Lysine	95-101	tumor protein p53	Homo sapiens	14-17
18234834-1	2008	It has been found that with mutation of two surface residues (Lys(22) --&gt; Glu and His(104) --&gt; Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement of catalytic activity in the chemical step.	Lysine	62-65	purine nucleoside phosphorylase	Homo sapiens	115-146
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	Rac family small GTPase 2	Homo sapiens	36-39
18022807-2	2008	TEL is modified by SUMOylation, and the lysine (Lys 99) that is conjugated to SUMO is required for TEL nuclear export.	Lysine	40-46	ETS variant transcription factor 6	Homo sapiens	99-102
18022807-2	2008	TEL is modified by SUMOylation, and the lysine (Lys 99) that is conjugated to SUMO is required for TEL nuclear export.	Lysine	48-51	ETS variant transcription factor 6	Homo sapiens	99-102
18022807-6	2008	However, impairment of both SUMOylation of Lys 99 and p38-dependent phosphorylation of Ser 257 of TEL were required to impair the re-localization of TEL in response to cellular stress induced by high salt, identifying two separate nuclear export pathways.	Lysine	43-46	ETS variant transcription factor 6	Homo sapiens	149-152
18326044-5	2008	It is currently accepted that this enzyme polyubiquitylates A3G on lysine residues, resulting in its degradation by proteasomes.	Lysine	67-73	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	60-63
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	Rac family small GTPase 2	Homo sapiens	151-154
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	Rac family small GTPase 2	Homo sapiens	36-39
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	Rac family small GTPase 2	Homo sapiens	151-154
18356165-5	2008	HDAC6 deacetylates beta-catenin at lysine 49, a site frequently mutated in anaplastic thyroid cancer, and inhibits beta-catenin phosphorylation at serine 45.	Lysine	35-41	histone deacetylase 6	Homo sapiens	0-5
18313392-2	2008	In the present study, we revealed by ChIP assay using a cryostat sectioning technique that binding of the di-acetylated histone H3 at lysine 9/14 and the transcriptional factor Cdx-2 to the promoter region on the SI gene, as well as mRNA, increased in the transient process.	Lysine	134-140	caudal type homeo box 2	Rattus norvegicus	177-182
18451980-6	2008	In addition, reduced or increased amounts of SU(VAR)3-7 result in redistribution of the DCC proteins MSL1 and MSL2, and of Histone 4 acetylation of lysine 16, indicating that a wild-type dose of SU(VAR)3-7 is required for X-restricted DCC targeting.	Lysine	148-154	Suppressor of variegation 3-7	Drosophila melanogaster	45-55
18171325-1	2008	In the present study we show that the interaction of the CaM (calmodulin)-binding domain (Lys(3614)-Asn(3643)) with the Cys(4114)-Asn(4142) region (a region included in the CaM-like domain) serves as an intrinsic regulator of the RyR1 (type-1 ryanodine receptor).	Lysine	90-93	ryanodine receptor 1	Homo sapiens	230-234
18029035-0	2008	Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain.	Lysine	89-95	coiled-coil domain containing 50	Homo sapiens	15-19
18029035-0	2008	Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain.	Lysine	89-95	nuclear factor kappa B subunit 1	Homo sapiens	38-47
18029035-4	2008	Ymer, which has been reported to be highly phosphorylated on tyrosine residues via EGF stimulation, bound to lysine (K)-63-linked polyubiquitin chain on receptor-interacting serine/threonine-protein kinase 1 (RIP1), which is essential for NF-kappaB signaling in collaboration with A20.	Lysine	109-115	coiled-coil domain containing 50	Homo sapiens	0-4
18029035-4	2008	Ymer, which has been reported to be highly phosphorylated on tyrosine residues via EGF stimulation, bound to lysine (K)-63-linked polyubiquitin chain on receptor-interacting serine/threonine-protein kinase 1 (RIP1), which is essential for NF-kappaB signaling in collaboration with A20.	Lysine	109-115	nuclear factor kappa B subunit 1	Homo sapiens	239-248
17710556-2	2008	Recently analyzed H3K9 methyltransferases (HMTases) as SUV39H1, Clr4p, DIM-5, Su(var)3-9 or SUVH2 are responsible for the establishment of histone H3 lysine 9 methylation (H3K9me), which is intimately connected with heterochromatinization.	Lysine	150-156	SUV39H1 histone lysine methyltransferase	Homo sapiens	55-62
18393372-8	2008	Using the chromatin immunoprecipitation assay, we found that LPS increased the binding of trimethylated histone 3 lysine 4 (H3K4) to the TNFalpha promoter, and this was completely blocked by either SAMe or MTA pretreatment.	Lysine	114-120	tumor necrosis factor	Mus musculus	137-145
18424718-3	2008	We show here that JunB is conjugated with small ubiquitin-like modifier (SUMO) on lysine 237 in resting and activated primary T cells and T cell lines.	Lysine	82-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22
18347056-0	2008	Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster.	Lysine	51-57	male-specific lethal 1	Drosophila melanogaster	123-126
18347056-2	2008	Transcription-coupled methylation of histone H3 lysine 36 is enriched toward the 3" end of active genes, similar to the MSL proteins.	Lysine	48-54	male-specific lethal 1	Drosophila melanogaster	120-123
18305112-2	2008	Here, we report that ARF associates with COMMD1 and promotes Lys(63)-mediated polyubiquitination of COMMD1 in a p53-independent manner.	Lysine	61-64	copper metabolism domain containing 1	Homo sapiens	100-106
18305112-2	2008	Here, we report that ARF associates with COMMD1 and promotes Lys(63)-mediated polyubiquitination of COMMD1 in a p53-independent manner.	Lysine	61-64	tumor protein p53	Homo sapiens	112-115
18305112-6	2008	Interestingly, we found that ARF promotes the polyubiquitination of COMMD1 through Lys(63) of ubiquitin but not the polyubiquitination of Lys(48), which does not target COMMD1 for proteasome-dependent proteolysis.	Lysine	83-86	copper metabolism domain containing 1	Homo sapiens	68-74
18305112-8	2008	Together, these data suggest that the ability to promote Lys(63)-mediated polyubiquitination of COMMD1 is a novel property of ARF independent of p53.	Lysine	57-60	copper metabolism domain containing 1	Homo sapiens	96-102
18305112-8	2008	Together, these data suggest that the ability to promote Lys(63)-mediated polyubiquitination of COMMD1 is a novel property of ARF independent of p53.	Lysine	57-60	tumor protein p53	Homo sapiens	145-148
18646558-1	2008	Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.	Lysine	27-33	coagulation factor II, thrombin	Homo sapiens	251-259
18319067-4	2008	Both mutations that affect mt-tRNA(Lys) (8363G&gt;A, 8344A&gt;G) resulted in severe combined deficiency of complexes I and IV, compared to an isolated severe defect of complex I in the 3243A&gt;G sample (mt-tRNA(LeuUUR).	Lysine	35-38	mitochondrially encoded tRNA glycine	Homo sapiens	30-34
18319067-4	2008	Both mutations that affect mt-tRNA(Lys) (8363G&gt;A, 8344A&gt;G) resulted in severe combined deficiency of complexes I and IV, compared to an isolated severe defect of complex I in the 3243A&gt;G sample (mt-tRNA(LeuUUR).	Lysine	35-38	mitochondrially encoded tRNA glycine	Homo sapiens	207-211
18304667-4	2008	Calculation of the variation in electrostatic free energy with pH indicated that deprotonation of Tyr, Lys and Arg side-chains at high pH would destabilize PrtG.	Lysine	103-106	protogenin	Homo sapiens	156-160
18171325-8	2008	These results suggest that the Lys(3614)-Asn(3643) and Cys(4114)-Asn(4142) regions of RyR1 interact with each other in a Ca2+- and agonist-dependent manner, and this serves as a mechanism of Ca2+- and agonist-dependent activation of the RyR1 Ca2+ channel.	Lysine	31-34	ryanodine receptor 1	Homo sapiens	86-90
18171325-8	2008	These results suggest that the Lys(3614)-Asn(3643) and Cys(4114)-Asn(4142) regions of RyR1 interact with each other in a Ca2+- and agonist-dependent manner, and this serves as a mechanism of Ca2+- and agonist-dependent activation of the RyR1 Ca2+ channel.	Lysine	31-34	ryanodine receptor 1	Homo sapiens	237-241
18160584-3	2008	The inhibitory concentrations 50% of lysine against urokinase or tissue-type plasminogen activator is 2.0 or 4.2 mM, against epsilon-amino-caproic acid 0.7 or 1.5 mM, against tranexamic acid 0.03 or 0.17 mM, respectively.	Lysine	37-43	plasminogen activator, tissue type	Homo sapiens	65-98
18201968-7	2008	We also found that suppression of STAT3, Oct-3/4, or Eed causes induction of differentiation-associated genes as well as loss of Lys(27)-trimethylated histone H3 at the promoter regions of the differentiation-associated genes.	Lysine	129-132	signal transducer and activator of transcription 3	Mus musculus	34-39
18327913-1	2008	We have investigated the contributions of hydrophobic residues, the conserved and variable proline residues, and the conserved lysine residues to the affinity and kinetics of thymosin beta4 (Tbeta4) binding to MgATP-actin monomers.	Lysine	127-133	thymosin beta 4 X-linked	Homo sapiens	175-189
18327913-1	2008	We have investigated the contributions of hydrophobic residues, the conserved and variable proline residues, and the conserved lysine residues to the affinity and kinetics of thymosin beta4 (Tbeta4) binding to MgATP-actin monomers.	Lysine	127-133	thymosin beta 4 X-linked	Homo sapiens	191-197
18298454-5	2008	In addition, Caco-2 cells had the same response to Toll-like receptor 2 (TLR2) ligand, Pam(3)Cys-Ser-(Lys)(4) as they did to LTA.	Lysine	102-105	toll like receptor 2	Homo sapiens	51-71
18339539-3	2008	In particular, the tumor suppressor and transcription factor p53 has provided a model for lysine methylation on a non-histone protein.	Lysine	90-96	tumor protein p53	Homo sapiens	61-64
18358708-3	2008	Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased HDAC1-C/EBPbeta interaction upon GCN5-mediated lysine acetylation, and the ability of sumoylation to inhibit C/EBPalpha-SWI/SNF interaction.	Lysine	180-186	histone deacetylase 1	Homo sapiens	133-138
18298454-5	2008	In addition, Caco-2 cells had the same response to Toll-like receptor 2 (TLR2) ligand, Pam(3)Cys-Ser-(Lys)(4) as they did to LTA.	Lysine	102-105	toll like receptor 2	Homo sapiens	73-77
18195007-6	2008	Lastly, a lysine replacement mutant recently reported to bind to negatively charged liposomes in a curvature-independent manner showed normal cellular distribution, suggesting that Golgi targeting of Arf-GAP1 may involve factors other than sensing lipid packing.	Lysine	10-16	ADP ribosylation factor GTPase activating protein 1	Homo sapiens	200-208
18285465-1	2008	The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia.	Lysine	15-21	DOT1 like histone lysine methyltransferase	Homo sapiens	43-48
18285465-1	2008	The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia.	Lysine	15-21	DOT1 like histone lysine methyltransferase	Homo sapiens	49-53
18250157-0	2008	Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.	Lysine	25-32	cyclin dependent kinase 9	Homo sapiens	58-83
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Lysine	235-241	cyclin dependent kinase 9	Homo sapiens	138-142
18428040-13	2008	For KALP the fit is more problematic due to the large solvation energies of the charged lysine residues.	Lysine	88-94	anosmin 2, pseudogene	Homo sapiens	4-8
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	CREB binding protein	Homo sapiens	122-142
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	CREB binding protein	Homo sapiens	144-147
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	CREB binding protein	Homo sapiens	122-142
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	CREB binding protein	Homo sapiens	144-147
18063693-4	2008	Arginine substitution of the sumoylatable lysine residue or alanine substitution of a nearby phosphorylatable serine residue (serine 19 in ERRalpha) increased the transcriptional activity of both ERRalpha and -gamma.	Lysine	42-48	estrogen related receptor, alpha	Mus musculus	196-215
18156491-3	2008	MMSET possesses methyltransferase activity for core histone H3 lysine 4 and histone 4 lysine 20, whereas MMSET made in cells only modified H4.	Lysine	63-69	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
18156491-3	2008	MMSET possesses methyltransferase activity for core histone H3 lysine 4 and histone 4 lysine 20, whereas MMSET made in cells only modified H4.	Lysine	86-92	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
18296633-5	2008	Using MyoD and Id1 mutants deficient in either N terminus-dependent or internal lysine-dependent ubiquitination, we further show that these ubiquitination pathways of MyoD degradation are regulated differently from those of Id1 degradation.	Lysine	80-86	myogenic differentiation 1	Homo sapiens	167-171
18063724-9	2008	Mutation of Cys610 in hSGLT1 to lysine resulted in an increased IC(50) for all inhibitors.	Lysine	32-38	solute carrier family 5 member 1	Homo sapiens	22-28
18275854-3	2008	In addition, AtGRX4 reduced iron accumulation and rescued the lysine auxotrophy of grx5 cells.	Lysine	62-68	glutaredoxin 4	Arabidopsis thaliana	13-19
18275854-3	2008	In addition, AtGRX4 reduced iron accumulation and rescued the lysine auxotrophy of grx5 cells.	Lysine	62-68	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	83-87
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	46-50
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	cadherin 1	Homo sapiens	103-113
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	cadherin 1	Homo sapiens	274-284
18369442-6	2008	Reactivation of silenced FMR1 alleles was accompanied by an increase in histone H3 lysine 9 acetylation as well as an increase in the amount of histone H4 that is acetylated at lysine 16 (H4K16) by the histone acetyltransferase, hMOF.	Lysine	83-89	fragile X messenger ribonucleoprotein 1	Homo sapiens	25-29
18369442-6	2008	Reactivation of silenced FMR1 alleles was accompanied by an increase in histone H3 lysine 9 acetylation as well as an increase in the amount of histone H4 that is acetylated at lysine 16 (H4K16) by the histone acetyltransferase, hMOF.	Lysine	177-183	fragile X messenger ribonucleoprotein 1	Homo sapiens	25-29
18079109-5	2008	The UBA domain of CIP75 is the main element mediating the interaction with Cx43, whereas the CIP75-interacting region in Cx43 resides in the PY motif and multiphosphorylation sites located between Lys 264 and Asn 302.	Lysine	197-200	ubiquilin 4	Homo sapiens	93-98
18172012-5	2008	Here, we report that RE-IIBP is up-regulated in the blood cells of leukemia patients, and we characterized the histone H3 lysine 27 (H3-K27) methyltransferase activity of RE-IIBP.	Lysine	122-128	nuclear receptor binding SET domain protein 2	Homo sapiens	21-28
18172012-5	2008	Here, we report that RE-IIBP is up-regulated in the blood cells of leukemia patients, and we characterized the histone H3 lysine 27 (H3-K27) methyltransferase activity of RE-IIBP.	Lysine	122-128	nuclear receptor binding SET domain protein 2	Homo sapiens	171-178
18375656-5	2008	In the atx1 mutant, FLC levels are reduced and the FLC chromatin is depleted of trimethylated, but not dimethylated, histone 3 lysine 4, suggesting a specific trimethylation function of ATX1.	Lysine	127-133	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	51-54
18093968-5	2008	Two SecS monomers interact intimately and together build up two identical active sites around PLP in a Schiff-base linkage with lysine 284.	Lysine	128-134	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	Mus musculus	4-8
18063813-2	2008	These lysines are essential for a rapid conversion of plasminogen to plasmin by tissue type plasminogen activator.	Lysine	6-13	plasminogen activator, tissue type	Homo sapiens	80-113
17724462-1	2008	EZH2 is a Polycomb group (PcG) protein that promotes the late-stage development of cancer by silencing a specific set of genes, at least in part through trimethylation of associated histone H3 on Lys 27 (H3K27).	Lysine	196-199	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
18177638-2	2008	We examined whether the actin-binding proteins cortactin, vinculin and filamin A are involved in the formation of the earliest extensions of cells spreading over collagen or poly-L-lysine-coated smooth and beaded substrates.	Lysine	174-187	filamin A	Homo sapiens	71-80
18166065-2	2008	Covalent immobilization of cyt c was achieved by the formation of an amide bond between the carboxylic groups of the conducting polymer and amines groups of lysine in cyt c.	Lysine	157-163	cytochrome c, somatic	Homo sapiens	27-32
18206295-6	2008	Interestingly, the total amount of Akt/PKB protein was dramatically increased in the presence of LY 294002.	Lysine	97-99	thymoma viral proto-oncogene 1	Mus musculus	35-42
18166065-2	2008	Covalent immobilization of cyt c was achieved by the formation of an amide bond between the carboxylic groups of the conducting polymer and amines groups of lysine in cyt c.	Lysine	157-163	cytochrome c, somatic	Homo sapiens	167-172
18184610-1	2008	Tissue transglutaminase (tTG) is a Ca(2+)-dependent enzyme catalyzing the formation of covalent crosslinks between peptide-bound glutamine and lysine residues.	Lysine	143-149	transglutaminase 2	Homo sapiens	0-23
18177270-7	2008	Hydroxylation and glycosylation of several conserved lysine residues in the collagenous domain of adiponectin are necessary for the intracellular assembly and stabilization of its high-order oligomeric structures.	Lysine	53-59	adiponectin, C1Q and collagen domain containing	Homo sapiens	98-109
18184610-1	2008	Tissue transglutaminase (tTG) is a Ca(2+)-dependent enzyme catalyzing the formation of covalent crosslinks between peptide-bound glutamine and lysine residues.	Lysine	143-149	transglutaminase 2	Homo sapiens	25-28
17977830-6	2008	This specific p53 phosphorylation at Ser(15) in turn results in acetylation of p53 at Lys(320) and Lys(373)/Lys(382) through transcriptional cofactors p300/CBP-associated factor and p300, respectively.	Lysine	86-89	tumor protein p53	Homo sapiens	14-17
18182242-4	2008	We previously developed a highly potent and selective BK B1R receptor antagonist, B9958 (Lys-Lys-[Hyp3, CpG5, d-Tic7, CpG8]des-Arg9-BK) (Hyp, trans-4-hydroxyproline; CpG, alpha-cyclopentylglycine; Tic, tetrahydroisoquinoline-3-carboxylic acid).	Lysine	89-92	bradykinin receptor B1	Homo sapiens	54-60
18182242-4	2008	We previously developed a highly potent and selective BK B1R receptor antagonist, B9958 (Lys-Lys-[Hyp3, CpG5, d-Tic7, CpG8]des-Arg9-BK) (Hyp, trans-4-hydroxyproline; CpG, alpha-cyclopentylglycine; Tic, tetrahydroisoquinoline-3-carboxylic acid).	Lysine	93-96	bradykinin receptor B1	Homo sapiens	54-60
18182242-5	2008	We now report on new BK B1R antagonist analogs of B9958 with N-terminal basic residues in the d-configuration, or Lys-, Orn- derivatives (NiK, epsilon-nicotinoyllysine; PzO, 3-pyrazinoylornithine) and/or having hindered unusual amino acids at position 5 (Igl, alpha-(2-indanyl)glycine).	Lysine	114-117	bradykinin receptor B1	Homo sapiens	21-27
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	216-219
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	216-219
17977830-6	2008	This specific p53 phosphorylation at Ser(15) in turn results in acetylation of p53 at Lys(320) and Lys(373)/Lys(382) through transcriptional cofactors p300/CBP-associated factor and p300, respectively.	Lysine	86-89	tumor protein p53	Homo sapiens	79-82
17977830-6	2008	This specific p53 phosphorylation at Ser(15) in turn results in acetylation of p53 at Lys(320) and Lys(373)/Lys(382) through transcriptional cofactors p300/CBP-associated factor and p300, respectively.	Lysine	99-102	tumor protein p53	Homo sapiens	14-17
17977830-6	2008	This specific p53 phosphorylation at Ser(15) in turn results in acetylation of p53 at Lys(320) and Lys(373)/Lys(382) through transcriptional cofactors p300/CBP-associated factor and p300, respectively.	Lysine	99-102	tumor protein p53	Homo sapiens	14-17
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	165-168	tumor protein p53	Homo sapiens	6-9
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	165-168	tumor protein p53	Homo sapiens	158-161
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	174-177	tumor protein p53	Homo sapiens	6-9
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	174-177	tumor protein p53	Homo sapiens	158-161
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	174-177	tumor protein p53	Homo sapiens	6-9
17977830-7	2008	These p53 posttranslational modifications are directly responsible for 5-aza-CdR induced p21(Waf1/Cip1) expression because the binding activity of acetylated p53 at Lys(320)/Lys(373)/Lys(382) to the p21(Waf1/Cip1) promoter, as well as p21(Waf1/Cip1) expression itself are significantly increased after 5-aza-CdR treatment.	Lysine	174-177	tumor protein p53	Homo sapiens	158-161
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	74-77	tumor protein p53	Homo sapiens	23-26
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	74-77	tumor protein p53	Homo sapiens	216-219
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	74-77	tumor protein p53	Homo sapiens	216-219
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	23-26
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	216-219
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	216-219
17977830-8	2008	It is of interest that p53 phosphorylation at Ser(15) and acetylations at Lys(320)/Lys(373)/Lys(382) mutually interact in the 5-aza-CdR induced p21(Waf1/Cip1) expression shown by transfection of artificially mutated p53 expression vectors including S15A, K320R, and K373R/K382R into p53-null H1299 cells.	Lysine	83-86	tumor protein p53	Homo sapiens	23-26
18192848-9	2008	Acetylation of p53 at the Sirt1-specific lysine 373/382 site was markedly decreased.	Lysine	41-47	sirtuin 1	Rattus norvegicus	26-31
18231594-5	2008	We find that expression of the human p53-Mdm2 module in yeast is sufficient to faithfully recapitulate key aspects of p53 regulation in higher eukaryotes, such as Mdm2-dependent targeting of p53 for degradation, sumoylation at lysine 386 and further regulation of this process by p14(ARF).	Lysine	227-233	tumor protein p53	Homo sapiens	37-40
18077552-5	2008	We show that Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation.	Lysine	35-41	leucine rich repeat and sterile alpha motif containing 1	Homo sapiens	13-16
18281509-4	2008	We show that AG regulatory sequences are required for its ectopic expression in both emf1 and emf2 mutants and that EMF2 is required for trimethylation of histone 3 lysine 27 on the AG chromatin.	Lysine	165-171	VEFS-Box of polycomb protein	Arabidopsis thaliana	116-120
18006692-10	2008	His107 (EC2-BRS-3) for lysine (H107K) (EC2-GRPR) decreased affinity (25- and 0-fold) for peptides 4 and 1; however, it could not be activated by either peptide.	Lysine	23-29	gastrin releasing peptide receptor	Homo sapiens	43-47
18231594-5	2008	We find that expression of the human p53-Mdm2 module in yeast is sufficient to faithfully recapitulate key aspects of p53 regulation in higher eukaryotes, such as Mdm2-dependent targeting of p53 for degradation, sumoylation at lysine 386 and further regulation of this process by p14(ARF).	Lysine	227-233	tumor protein p53	Homo sapiens	118-121
18231594-5	2008	We find that expression of the human p53-Mdm2 module in yeast is sufficient to faithfully recapitulate key aspects of p53 regulation in higher eukaryotes, such as Mdm2-dependent targeting of p53 for degradation, sumoylation at lysine 386 and further regulation of this process by p14(ARF).	Lysine	227-233	tumor protein p53	Homo sapiens	118-121
18178621-4	2008	As a result of vernalization, levels of lysine-9 and lysine-27 trimethylation on histone 3, modifications that are characteristic of facultative heterochromatin in plants, increase at FLC chromatin.	Lysine	40-46	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	184-187
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Lysine	114-117	proopiomelanocortin	Homo sapiens	143-179
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Lysine	114-117	proopiomelanocortin	Homo sapiens	181-190
18039665-1	2008	VEK-30, a 30-amino acid internal peptide present within a streptococcal M-like plasminogen (Pg)-binding protein (PAM) from Gram-positive group-A streptococci (GAS), represents an epitope within PAM that shows high affinity for the lysine binding site (LBS) of the kringle-2 (K2) domain of human (h)Pg.	Lysine	231-237	N-methylpurine-DNA glycosylase	Mus musculus	92-94
18178621-4	2008	As a result of vernalization, levels of lysine-9 and lysine-27 trimethylation on histone 3, modifications that are characteristic of facultative heterochromatin in plants, increase at FLC chromatin.	Lysine	53-59	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	184-187
18273892-6	2008	In follow-up work devised to explore the potential benefit of contacting additional cell surface EPO receptors, we designed a tetrameric template consisting of lysine-based dimers joined via commercial PEG linkers of various molecular weights.	Lysine	160-166	erythropoietin	Homo sapiens	97-100
17988081-2	2008	In this paper, we describe the posttranslational modification of different IgGs via the Lys or Gln side chains catalyzed by bacterial and human tissue transglutaminase (BTGase and TG2).	Lysine	88-91	transglutaminase 2	Homo sapiens	144-167
18067580-2	2008	Hypusine is formed by post-translational modification of one specific lysine (Lys50 for human eIF5A) by deoxyhypusine synthase and deoxyhypusine hydroxylase.	Lysine	70-76	deoxyhypusine synthase	Homo sapiens	104-126
17994216-7	2008	Among growth factors, only human growth hormone (hGH) and the glucagon-like peptide-1 analogue liraglutide enhanced proliferation of rat beta cells, with a significant increase on both poly-L-lysine and ECM.	Lysine	185-198	growth hormone 1	Homo sapiens	33-47
17994216-7	2008	Among growth factors, only human growth hormone (hGH) and the glucagon-like peptide-1 analogue liraglutide enhanced proliferation of rat beta cells, with a significant increase on both poly-L-lysine and ECM.	Lysine	185-198	glucagon	Homo sapiens	62-85
18076215-1	2008	Insulin glulisine injection [3(B)-Lys, 29(B)-Glu-human insulin] is the newest human insulin analogue product for the control of mealtime blood sugar.	Lysine	34-37	insulin	Homo sapiens	0-7
18007656-3	2008	We show that RAD16 is required for ultraviolet-dependent hyperacetylation of histone H3 (Lys 9 and Lys 14) at the MFA2 promoter and throughout the genome.	Lysine	89-92	DNA repair protein RAD16	Saccharomyces cerevisiae S288C	13-18
18007656-3	2008	We show that RAD16 is required for ultraviolet-dependent hyperacetylation of histone H3 (Lys 9 and Lys 14) at the MFA2 promoter and throughout the genome.	Lysine	99-102	DNA repair protein RAD16	Saccharomyces cerevisiae S288C	13-18
18093184-0	2008	Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process.	Lysine	75-78	mitogen-activated protein kinase 8	Homo sapiens	93-96
18436469-0	2008	Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.	Lysine	18-25	poly(ADP-ribose) polymerase 2	Homo sapiens	39-45
18436469-3	2008	Site directed mutagenesis indicated that lysines 36 and 37, located in the nuclear localization signal of PARP-2, are the main targets for PCAF and GCN5L activity in vitro.	Lysine	41-48	poly(ADP-ribose) polymerase 2	Homo sapiens	106-112
18436469-5	2008	Finally, PARP-2 with mutated lysines 36 and 37 showed reduced auto-mono-ADP-ribosylation when compared to wild type PARP-2.	Lysine	29-36	poly(ADP-ribose) polymerase 2	Homo sapiens	9-15
18436469-5	2008	Finally, PARP-2 with mutated lysines 36 and 37 showed reduced auto-mono-ADP-ribosylation when compared to wild type PARP-2.	Lysine	29-36	poly(ADP-ribose) polymerase 2	Homo sapiens	116-122
17967882-1	2008	Methylation of histone H4 at lysine 20 (K20) has been implicated in transcriptional activation, gene silencing, heterochromatin formation, mitosis, and DNA repair.	Lysine	29-35	keratin 20	Homo sapiens	40-43
17951556-4	2008	Our analysis of the effects of a deubiquitinating enzyme, Ubp2, demonstrated that an accumulation of Lys-63-linked polyubiquitin chains results in processed forms of two substrates, Sla1 and Ygr068c.	Lysine	101-104	Src like adaptor	Homo sapiens	182-186
17631966-7	2008	Protein sequencing of IgE fragments cleaved by highly pure preparations of the chymotrypsin-like enzyme revealed that cleavage also occurred post Lys residues within kappa light chain dimers (LELK/GA).	Lysine	146-149	immunoglobulin heavy constant epsilon	Homo sapiens	22-25
17959710-5	2008	The fact that the Ile6.40(420)Arg/Lys/Glu mutant receptors are highly active CAM H(1)Rs leads us to suggest that a positively charged residue, presumably the highly conserved Arg3.50 from the DRY motif, interacts in a direct or an indirect (through other side chains or/and internal water molecules) manner with the acidic Asp2.50..Asn7.49 pair for receptor activation.	Lysine	34-37	beta-secretase 1	Homo sapiens	323-327
17885205-3	2008	After receptor cleavage and Edman sequencing, it was shown that Asn(28) of VIP is in contact with Lys(127) in the receptor N-ted.	Lysine	98-101	vasoactive intestinal peptide	Homo sapiens	75-78
18852888-3	2008	RIZ1 (PRDM2 or KMT8) is a tumor suppressor and functions in transcriptional repression by methylating histone H3 lysine 9.	Lysine	113-119	PR domain containing 2, with ZNF domain	Mus musculus	0-4
18852888-3	2008	RIZ1 (PRDM2 or KMT8) is a tumor suppressor and functions in transcriptional repression by methylating histone H3 lysine 9.	Lysine	113-119	PR domain containing 2, with ZNF domain	Mus musculus	6-11
18852898-3	2008	In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci.	Lysine	94-100	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	135-138
18852888-3	2008	RIZ1 (PRDM2 or KMT8) is a tumor suppressor and functions in transcriptional repression by methylating histone H3 lysine 9.	Lysine	113-119	PR domain containing 2, with ZNF domain	Mus musculus	15-19
18852898-3	2008	In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci.	Lysine	193-199	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	135-138
18852888-8	2008	Higher RIZ1 activity was associated with greater H3 lysine 9 methylation in RIZ1 target genes as shown by chromatin immunoprecipitation analysis.	Lysine	52-58	PR domain containing 2, with ZNF domain	Mus musculus	7-11
18852898-3	2008	In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci.	Lysine	193-199	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	143-146
18852888-8	2008	Higher RIZ1 activity was associated with greater H3 lysine 9 methylation in RIZ1 target genes as shown by chromatin immunoprecipitation analysis.	Lysine	52-58	PR domain containing 2, with ZNF domain	Mus musculus	76-80
18629373-4	2008	In the fasting state, LYs compared with LYr not only evoked a &gt;2-fold increase in plasma lycopene but also increased plasma beta-carotene and alpha-tocopherol (p &lt; 0.01), though LYs did not affect plasma nitrate/nitrite (biomarker of nitric oxide), malondialdehyde (biomarker of lipid oxidative stress), vascular- and intercellular-adhesion molecules or C-reactive protein (biomarkers of inflammation).	Lysine	22-25	C-reactive protein	Homo sapiens	360-378
19112497-6	2008	Likewise, lysine-deficient TRAF6 was found to interact with the TAK1-TAB1-TAB2 complex, but surprisingly was also found to be fully competent to activate TAK1, as well as NFkappaB and AP-1 reporters.	Lysine	10-16	nuclear factor kappa B subunit 1	Homo sapiens	171-179
19112497-7	2008	Furthermore, lysine-deficient TRAF6 rescued IL-1-mediated NFkappaB and MAPK activation, as well as IL-6 elaboration in retrovirally-rescued TRAF6-deficient fibroblasts.	Lysine	13-19	nuclear factor kappa B subunit 1	Homo sapiens	58-66
19112497-8	2008	Lysine-deficient TRAF6 also rescued RANKL-mediated NFkappaB and MAPK activation, and osteoclastogenesis in retrovirally-rescued TRAF6-deficient bone marrow macrophages.	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	51-59
17766101-4	2007	To optimize the adhesion of P450scc to APA, a layer of poly-L-lysine, a poly-cathion, was successfully implemented as intermediate organic structure.	Lysine	55-68	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	28-35
17951578-5	2007	Interestingly, propionyl- and butyryl-lysine peptides were found to bind tighter to Hst2 compared with acetyl-lysine peptide and showed measurable rates of catalysis with Hst2, Sirt1, Sirt2, and Sirt3, suggesting propionyl- and butyryl-lysine proteins may be sirtuin substrates in vivo.	Lysine	38-44	sirtuin 3	Homo sapiens	195-200
18077430-5	2007	We found that the JAZF1-JJAZ1 fusion restored levels of the polycomb protein EZH2 and histone 3 lysine 27 trimethylation, which were reduced by knockdown of endogenous JJAZ1.	Lysine	96-102	JAZF zinc finger 1	Homo sapiens	18-23
18075593-4	2007	Here we show that CLOCK also acetylates a non-histone substrate: its own partner, BMAL1, is specifically acetylated on a unique, highly conserved Lys 537 residue.	Lysine	146-149	circadian locomotor output cycles kaput	Mus musculus	18-23
18045085-1	2007	A macrocyclic calix[6]arene carboxylic acid derivative is found to extract lysine-rich protein cytochrome c from aqueous media into organic media through the complexation between the calixarene molecules and lysine residues on the surface of the protein.	Lysine	75-81	cytochrome c, somatic	Homo sapiens	95-107
17991829-6	2007	DUBA selectively cleaved the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signaling complex containing TANK-binding kinase 1.	Lysine	29-35	OTU deubiquitinase 5	Homo sapiens	0-4
20641698-15	2004	(12) showed that the kidney uptake of a short linear DOTA-alpha-MSH analog (DOTA-NAPamide) could be considerably reduced by neutralizing the charge of the Lys(11) residue.	Lysine	155-158	proopiomelanocortin	Homo sapiens	58-67
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	91-97	transglutaminase 2	Homo sapiens	0-23
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	91-97	transglutaminase 2	Homo sapiens	25-28
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	155-163	transglutaminase 2	Homo sapiens	0-23
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	155-163	transglutaminase 2	Homo sapiens	25-28
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	157-163	transglutaminase 2	Homo sapiens	0-23
17869334-3	2007	Tissue transglutaminase (tTG), a Ca2+-dependent enzyme that catalyzes the reaction between lysine and glutamine residues to form a epsilon(gamma-glutaminyl) lysine isopeptide bond, was incubated with cartilage in the presence of lysine (FKG-NH2) and glutamine (GQQQLG-NH2) peptides as well as peptide functionalized poly(ethylene glycol) (PEG).	Lysine	157-163	transglutaminase 2	Homo sapiens	25-28
18045085-1	2007	A macrocyclic calix[6]arene carboxylic acid derivative is found to extract lysine-rich protein cytochrome c from aqueous media into organic media through the complexation between the calixarene molecules and lysine residues on the surface of the protein.	Lysine	208-214	cytochrome c, somatic	Homo sapiens	95-107
17889218-5	2007	Although Lys-modified notexin retained full PLA(2) activity, a notable decrease in membrane-damaging activity was observed.	Lysine	9-12	phospholipase A2 group IB	Homo sapiens	44-50
17765667-4	2007	This analysis led to the identification of a critical hot-spot for DNA substrate recognition composed of two neighboring lysines at codons 141 and 179 of the human XPA sequence.	Lysine	121-128	XPA, DNA damage recognition and repair factor	Homo sapiens	164-167
17898049-5	2007	Treatment of E7-expressing cells with interferon ultimately resulted in cellular senescence through a process that is dependent upon acetylation of p53 by p300/CBP at lysine 382.	Lysine	167-173	tumor protein p53	Homo sapiens	148-151
17898049-5	2007	Treatment of E7-expressing cells with interferon ultimately resulted in cellular senescence through a process that is dependent upon acetylation of p53 by p300/CBP at lysine 382.	Lysine	167-173	CREB binding protein	Homo sapiens	160-163
17898049-8	2007	Finally, p53 acetylation at lysine 382 was found not to be an essential determinant of other types of senescence such as that induced by overexpression of Ras in human fibroblasts.	Lysine	28-34	tumor protein p53	Homo sapiens	9-12
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	tumor protein p53	Homo sapiens	268-271
17931351-7	2007	Chromatin immunoprecipitation assays revealed association with dimethyl histone H3 lysine 9 (H3K9me2), a heterochromatic marker, within the phyA" coding region.	Lysine	83-89	phytochrome A	Arabidopsis thaliana	140-144
17901401-5	2007	The insulin gene in islets displays high levels of histone modifications (H4 hyperacetylation and dimethylation of H3 lysine 4) typical of active genes.	Lysine	118-124	insulin	Homo sapiens	4-11
18085569-2	2007	We show that bradykinin and three modified peptides containing the basic residue arginine or lysine form stable interactions with single-stranded oligonucleotides.	Lysine	93-99	kininogen 1	Homo sapiens	13-23
17938208-5	2007	CHD8 binds to histone H3 di- and trimethylated on lysine 4.	Lysine	50-56	chromodomain helicase DNA binding protein 8	Homo sapiens	0-4
18042460-2	2007	Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark.	Lysine	107-113	bromodomain PHD finger transcription factor	Homo sapiens	32-36
17985933-9	2007	Residues Lys 7 and Arg 5 play important roles in the interaction with MEK5 PB1.	Lysine	9-12	mitogen-activated protein kinase kinase 5	Homo sapiens	70-74
17963781-3	2007	Here we report that the alpha-NH(2) group of the N terminus and the epsilon-NH(2) groups of internal lysine residues 116, 118 and 269 (K116, K118 and K269) of Smad1 are ubiquitin acceptor sites mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP).	Lysine	101-107	ST13 Hsp70 interacting protein	Homo sapiens	231-256
17901049-7	2007	Mutations of four lysine residues to alanine in IRS-2 protein, on the other hand, led to its reduced basal level acetylation and insulin-induced tyrosine phosphorylation.	Lysine	18-24	insulin	Homo sapiens	129-136
17948050-8	2007	Malt1 mutants that lack C-terminal ubiquitin acceptor lysines are impaired in rescuing NF-kappaB signaling and IL-2 production in Malt1-/- T cells.	Lysine	54-61	interleukin 2	Homo sapiens	111-115
17908689-7	2007	We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target genes, suggesting that acetylation is important for KLF4-mediated transactivation.	Lysine	130-137	CREB binding protein	Homo sapiens	81-84
18006806-1	2007	The Polycomb Group (PcG) protein EZH2 is a critical component of a multiprotein complex that methylates Lys(27) of histone 3 (H3K27), which consequently leads to the repression of target gene expression.	Lysine	104-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
18006819-0	2007	The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.	Lysine	4-10	fms related receptor tyrosine kinase 1	Homo sapiens	18-63
18006819-3	2007	We further identified the methylated residue at VEGFR1 lysine 831, which is located in the kinase domain and is conserved among VEGFR1 orthologues.	Lysine	55-61	fms related receptor tyrosine kinase 1	Homo sapiens	48-54
18006819-3	2007	We further identified the methylated residue at VEGFR1 lysine 831, which is located in the kinase domain and is conserved among VEGFR1 orthologues.	Lysine	55-61	fms related receptor tyrosine kinase 1	Homo sapiens	128-134
18004385-4	2007	SUV39H1 is the principal enzyme responsible for the accumulation of histone H3 containing a tri-methyl group at its lysine 9 position (H3K9me3) in regions of heterochromatin.	Lysine	116-122	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
17936785-7	2007	The suppressor mutations allowed export of the native Esherichia coli Tat substrate trimethylamine N-oxide reductase with a twin-lysine substitution in its signal sequence.	Lysine	129-135	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	70-73
17980595-0	2007	Vernalization-induced trimethylation of histone H3 lysine 27 at FLC is not maintained in mitotically quiescent cells.	Lysine	51-57	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	64-67
17980595-3	2007	Plant polycomb proteins FIE, VRN2, CLF, and SWN, together with VIN3, form a complex that adds histone H3 lysine 27 methylation at FLC in vernalized plants.	Lysine	105-111	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	24-27
17980595-3	2007	Plant polycomb proteins FIE, VRN2, CLF, and SWN, together with VIN3, form a complex that adds histone H3 lysine 27 methylation at FLC in vernalized plants.	Lysine	105-111	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	130-133
18004385-7	2007	Here we show that the mammalian histone methyltransferase SUV39H1 is itself targeted by the histone deacetylase SIRT1 and that SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain.	Lysine	175-181	SUV39H1 histone lysine methyltransferase	Homo sapiens	58-65
18004385-7	2007	Here we show that the mammalian histone methyltransferase SUV39H1 is itself targeted by the histone deacetylase SIRT1 and that SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain.	Lysine	175-181	SUV39H1 histone lysine methyltransferase	Homo sapiens	127-134
17927217-3	2007	By substituting Ser-49 and three other residues in the Ca2+-binding loop of AtnL, we obtained the first two enzymatically active mutants of Lys-49/Ser-49 sPLA2 homologues.	Lysine	140-143	phospholipase A2 group X	Homo sapiens	154-159
17996705-3	2007	Here we show that the acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains.	Lysine	41-47	tumor protein p53	Homo sapiens	60-63
17927217-8	2007	Our results indicate that, in evolution, Lys-49 and Ser-49 sPLA2 myotoxins have lost their Ca2+-binding ability and enzymatic activity through subtle changes in the Ca2+-binding network without affecting the rest of the catalytic machinery, thereby optimizing their Ca2+-independent membrane-damaging ability and myotoxic activity.	Lysine	41-44	phospholipase A2 group X	Homo sapiens	59-64
17996705-4	2007	UV irradiation of cells diacetylates p53 at lysines 373 and 382, which in turn recruits TAF1 to a distal p53-binding site on the p21 promoter prior to looping to the core promoter.	Lysine	44-51	tumor protein p53	Homo sapiens	37-40
17603054-9	2007	The first gene defect was identified in a patient with associated right renal agenesis who had two point mutations in the KAL1 gene: the first was a G to A transition in exon 11, turning codon 514 encoding glutamic acid into lysine; and the second was a G to A transition in exon 13, turning codon 660 encoding alanine into threonine.	Lysine	225-231	anosmin 1	Homo sapiens	122-126
17620057-8	2007	Deacetylated lysine residues within Rb formed a domain similar to the SIRT1-targeted domain of the p53 tumour suppressor protein.	Lysine	13-19	tumor protein p53	Homo sapiens	99-102
17425515-0	2007	A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.	Lysine	21-27	beta-secretase 1	Homo sapiens	106-111
17425515-3	2007	In the present study we report that BACE1 is acetylated on seven lysine residues of the N-terminal portion of the nascent protein.	Lysine	65-71	beta-secretase 1	Homo sapiens	36-41
17425515-7	2007	Site-directed mutagenesis indicates that lysine acetylation is necessary for nascent BACE1 to leave the ER and move ahead in the secretory pathway, and for the molecular stabilization of the protein.	Lysine	41-47	beta-secretase 1	Homo sapiens	85-90
17785452-6	2007	The DLG motif works to correctly position the lysines within the Nrf2 Neh2 domain for efficient ubiquitination.	Lysine	46-53	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
17922839-9	2007	Because conservative Lys residues located in the beta5-beta7 loop and in the beta7 strand appear to play an important role in the structure and properties of HSP22, mutations in this part of the small heat shock protein molecule might have a deleterious effect and often correlate with the development of different congenital diseases.	Lysine	21-24	heat shock protein family B (small) member 8	Homo sapiens	158-163
17440973-5	2007	PIAS1 enhanced the SUMOylation at lysine 396 of mouse SOX9.	Lysine	34-40	protein inhibitor of activated STAT 1	Mus musculus	0-5
17875926-3	2007	Here we report that the protein encoded by YJR119c (termed KDM5), coding for one of five predicted jumonji domain proteins in yeast, specifically demethylates trimethylated histone H3 lysine 4 (H3K4me3), H3K4me2, and H3K4me1 in vitro.	Lysine	184-190	histone demethylase	Saccharomyces cerevisiae S288C	59-63
17884024-4	2007	In the present study we mutated the equivalent lysine in the rat AMPA receptor subunit GluR1 flip to alanine (K445A) and assessed changes in nucleotide affinity from the displacement of [(3)H]fluorowillardiine.	Lysine	47-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
17868694-6	2007	The active site of hQPRTase is located at an alpha/beta open sandwich structure that serves as a cup for the alpha/beta barrel of the adjacent subunit with a QA binding site consisting of three arginine residues (R102, R138 and R161) and two lysine residues (K139 and K171).	Lysine	242-248	quinolinate phosphoribosyltransferase	Homo sapiens	19-27
17914575-6	2007	A comparison with the wild-type after 1 nano-second molecular dynamic simulation analysis revealed a significant structural change (over 4A displacement) in the contact loop Lys-Ser-Val which lies upstream and next to the mutated site in the TP53, that sterically prevents its DNA-binding activity.	Lysine	174-177	tumor protein p53	Homo sapiens	242-246
17924656-9	2007	We demonstrate that ActRIIbE76K and ActRII bind BMP-3 with similar affinity, indicating BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb.	Lysine	151-154	activin A receptor type 2A	Homo sapiens	20-26
17935739-9	2007	Pre-treatment with Wortmannin, LY 294002, PD 098,059 and SB 203580 caused a significant decrease in nitrite production, NOS type II protein expression and NOS type II mRNA expression induced by leptin and interferon-gamma co-stimulation.	Lysine	31-33	nitric oxide synthase 2, inducible	Mus musculus	120-131
17935739-9	2007	Pre-treatment with Wortmannin, LY 294002, PD 098,059 and SB 203580 caused a significant decrease in nitrite production, NOS type II protein expression and NOS type II mRNA expression induced by leptin and interferon-gamma co-stimulation.	Lysine	31-33	nitric oxide synthase 2, inducible	Mus musculus	155-166
17935739-9	2007	Pre-treatment with Wortmannin, LY 294002, PD 098,059 and SB 203580 caused a significant decrease in nitrite production, NOS type II protein expression and NOS type II mRNA expression induced by leptin and interferon-gamma co-stimulation.	Lysine	31-33	interferon gamma	Mus musculus	205-221
17940017-4	2007	To examine whether this internalization was mediated by the residual ubiquitination, systematic mutagenesis of lysine residues in the kinase domain of the EGFR was performed to generate a receptor mutant that is not ubiquitinated.	Lysine	111-117	epidermal growth factor receptor	Homo sapiens	155-159
17940017-5	2007	Mutations of a number of lysines inhibited kinase activity of the EGFR, thus leading to the inhibition of receptor internalization.	Lysine	25-32	epidermal growth factor receptor	Homo sapiens	66-70
17925448-4	2007	Of the four genes identified, three, SET1, SWD1, and SWD3, encode components of the Set1 complex, which catalyzes the methylation of histone H3 on lysine 4 (H3-K4), a highly conserved modification that occurs in the coding sequences of transcribed genes.	Lysine	147-153	Swd3p	Saccharomyces cerevisiae S288C	53-57
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Lysine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17940047-2	2007	Recently, to elucidate the oligomerization pathway, we studied Abeta monomer folding and identified a decapeptide segment of Abeta, (21)Ala-(22)Glu-(23)Asp-(24)Val-(25)Gly-(26)Ser-(27)Asn-(28)Lys-(29)Gly-(30)Ala, within which turn formation appears to nucleate monomer folding.	Lysine	192-195	amyloid beta precursor protein	Homo sapiens	125-130
17675297-5	2007	Recombinant forms of Pellino1 and Pellino2 and both spliced variants of Pellino3 are shown in an in vitro ubiquitination assay to be E3 ligases that catalyze Lys(63)-linked polyubiquitination, with Pellino3 exhibiting the greatest ligase activity.	Lysine	158-161	pellino E3 ubiquitin protein ligase family member 2	Homo sapiens	34-42
17937819-5	2007	Replacement of cytosolic lysine residues reduced but did not prevent Vpu-mediated CD4 degradation and ubiquitination, suggesting that Vpu-mediated CD4 degradation is not entirely dependent on the ubiquitination of cytosolic lysines and as such might also involve ubiquitination of other sites.	Lysine	25-31	CD4 molecule	Homo sapiens	147-150
17845900-6	2007	Efficacy of a nutrient mixture (NM) containing lysine, proline, ascorbic acid, and green tea extract has been demonstrated for reducing VEGF and MMPs secretion by various cells.	Lysine	47-53	vascular endothelial growth factor A	Homo sapiens	136-140
17936708-7	2007	Mutational analysis demonstrates that while Ring1B is required for E3 function, Mel-18 directs this activity to H2A lysine 119 in chromatin.	Lysine	116-122	polycomb group ring finger 2	Homo sapiens	80-86
17713478-5	2007	Here we show that the human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3.	Lysine	101-104	lysine demethylase 6A	Homo sapiens	60-63
17917251-5	2007	Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation.	Lysine	80-83	interleukin 6	Homo sapiens	98-102
17917251-5	2007	Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation.	Lysine	80-83	AKT serine/threonine kinase 1	Homo sapiens	116-119
17917251-0	2007	LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.	Lysine	46-49	interleukin 6	Homo sapiens	9-13
17670826-8	2007	(i) Electrophoretic band shift and primer binding site assays show that hA3G reduces the annealing of tRNA(3)(Lys) 44 and 60%, respectively, but does not disrupt the annealed complex once formed.	Lysine	110-113	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	72-76
17917251-0	2007	LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.	Lysine	46-49	signal transducer and activator of transcription 3	Homo sapiens	37-42
17917251-0	2007	LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.	Lysine	46-49	AKT serine/threonine kinase 1	Homo sapiens	67-70
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	65-71	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	65-71	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	97-100	signal transducer and activator of transcription 3	Homo sapiens	79-84
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	97-100	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	97-100	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	154-157	signal transducer and activator of transcription 3	Homo sapiens	79-84
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	154-157	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	154-157	signal transducer and activator of transcription 3	Homo sapiens	131-136
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	89-92	signal transducer and activator of transcription 3	Homo sapiens	69-74
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	89-92	signal transducer and activator of transcription 3	Homo sapiens	191-196
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	200-203	signal transducer and activator of transcription 3	Homo sapiens	69-74
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	200-203	signal transducer and activator of transcription 3	Homo sapiens	191-196
17917251-4	2007	Moreover, acetylation of STAT3 at Lys-685 was suppressed by PI3K inhibitor LY294002, or a dominant negative Akt.	Lysine	34-37	signal transducer and activator of transcription 3	Homo sapiens	25-30
17917251-4	2007	Moreover, acetylation of STAT3 at Lys-685 was suppressed by PI3K inhibitor LY294002, or a dominant negative Akt.	Lysine	34-37	AKT serine/threonine kinase 1	Homo sapiens	108-111
17917251-5	2007	Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation.	Lysine	80-83	signal transducer and activator of transcription 3	Homo sapiens	57-62
18035832-6	2007	These observations are supported by computer modelling studies which suggest that the aldehyde group of (8) may covalently bind to a lysine residue in the SH2-kinase linker region situated in the proximity of the SH3 domain, which could promote a conformational change resulting in increased Src activity.	Lysine	133-139	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	292-295
17854217-7	2007	The high sensitivity of this technique is indicated by the fact that all 19 lysines in cytochrome c were detected as a cross-link product and 33% of all the Lys pairs within 20 A were also observed as a cross-link.	Lysine	76-83	cytochrome c, somatic	Homo sapiens	87-99
17728347-1	2007	Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling.	Lysine	139-146	bromodomain, testis-specific	Mus musculus	0-4
17709386-1	2007	Treatment of Saccharomyces cerevisiae cells with DNA-damaging agents elicits lysine 164-linked PCNA monoubiquitination by Rad6-Rad18.	Lysine	77-83	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	127-132
17646389-2	2007	Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53.	Lysine	29-35	tumor protein p53	Homo sapiens	51-54
17960133-0	2007	A substitution of arginine to lysine at the COOH-terminus of MIP caused a different binocular phenotype in a congenital cataract family.	Lysine	30-36	major intrinsic protein of lens fiber	Homo sapiens	61-64
17646389-2	2007	Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53.	Lysine	29-35	tumor protein p53	Homo sapiens	168-171
17646389-5	2007	Significantly, we show that lysine methylation of p53 is important for its subsequent acetylation, resulting in stabilization of the p53 protein.	Lysine	28-34	tumor protein p53	Homo sapiens	50-53
17646389-5	2007	Significantly, we show that lysine methylation of p53 is important for its subsequent acetylation, resulting in stabilization of the p53 protein.	Lysine	28-34	tumor protein p53	Homo sapiens	133-136
17646389-8	2007	Collectively, these results suggest that the cross talk between lysine methylation and acetylation is critical for p53 activation in response to DNA damage and that Set7/9 may play an important role in tumor suppression.	Lysine	64-70	tumor protein p53	Homo sapiens	115-118
17673466-8	2007	We identified acidic residues in the V5 domain that, when mutated to alanines or lysines, rendered PKC alpha sensitive to diacylglycerol.	Lysine	81-88	protein kinase C alpha	Homo sapiens	99-108
17673466-10	2007	Simultaneous reversal of the charges of the acidic residues in the V5 and the lysines in the C2 domain gave rise to a PKC alpha that was insensitive to diacylglycerol.	Lysine	78-85	protein kinase C alpha	Homo sapiens	118-127
17682057-4	2007	We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNMT1) complexes to Cyp1a1 promoter chromatin and inhibits histone marks induced by AHR-mediated gene transactivation, including phosphorylation of histone H3 Ser-10, trimethylation of H3 Lys-4, and various acetylation marks in histones H3 and H4.	Lysine	275-278	histone deacetylase 1	Homo sapiens	34-55
17682057-4	2007	We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNMT1) complexes to Cyp1a1 promoter chromatin and inhibits histone marks induced by AHR-mediated gene transactivation, including phosphorylation of histone H3 Ser-10, trimethylation of H3 Lys-4, and various acetylation marks in histones H3 and H4.	Lysine	275-278	histone deacetylase 1	Homo sapiens	81-86
17631495-8	2007	Surprisingly, PGC-1beta coactivation of tamoxifen-bound ERalpha depends partially on one of the LXXLL motifs of PGC-1beta and on Lys(362) of the ERalpha LBD (i.e. surfaces implicated in agonist-dependent interactions).	Lysine	129-132	PPARG coactivator 1 beta	Homo sapiens	14-23
17711305-4	2007	Competing with repair processes, oxidized CaM is a substrate for a peptidase activity that results in the selective cleavage of the C-terminal lysine (i.e., Lys148) that is expected to diminish CaM function.	Lysine	143-149	calmodulin 1	Homo sapiens	42-45
17711305-4	2007	Competing with repair processes, oxidized CaM is a substrate for a peptidase activity that results in the selective cleavage of the C-terminal lysine (i.e., Lys148) that is expected to diminish CaM function.	Lysine	143-149	calmodulin 1	Homo sapiens	194-197
17713929-0	2007	Alkaline conformational transition and gated electron transfer with a Lys 79 --&gt; his variant of iso-1-cytochrome c.	Lysine	70-73	cytochrome c, somatic	Homo sapiens	105-117
17713929-1	2007	To probe the mechanism of the alkaline conformational transition and its effect on the dynamics of gated electron transfer (ET) reactions, a Lys 79 --&gt; His (K79H) variant of iso-1-cytochrome c has been prepared.	Lysine	141-144	cytochrome c, somatic	Homo sapiens	183-195
17609214-7	2007	Two positively charged residues in this domain, one of which is conserved in all putative CerS in all organisms, are essential for activity since site-directed mutagenesis of either (Lys-134 and Lys-140 in CerS5) results in an approximately 50% loss of activity, whereas mutation of both leads to a complete loss of activity.	Lysine	183-186	ceramide synthase 5	Homo sapiens	206-211
17609214-7	2007	Two positively charged residues in this domain, one of which is conserved in all putative CerS in all organisms, are essential for activity since site-directed mutagenesis of either (Lys-134 and Lys-140 in CerS5) results in an approximately 50% loss of activity, whereas mutation of both leads to a complete loss of activity.	Lysine	195-198	ceramide synthase 5	Homo sapiens	206-211
17631495-8	2007	Surprisingly, PGC-1beta coactivation of tamoxifen-bound ERalpha depends partially on one of the LXXLL motifs of PGC-1beta and on Lys(362) of the ERalpha LBD (i.e. surfaces implicated in agonist-dependent interactions).	Lysine	129-132	estrogen receptor 1	Homo sapiens	56-63
17631495-8	2007	Surprisingly, PGC-1beta coactivation of tamoxifen-bound ERalpha depends partially on one of the LXXLL motifs of PGC-1beta and on Lys(362) of the ERalpha LBD (i.e. surfaces implicated in agonist-dependent interactions).	Lysine	129-132	estrogen receptor 1	Homo sapiens	145-152
17646159-4	2007	We found increased TNFalpha mRNA levels in endotoxin-responsive cells that was preceded by dissociation of heterochromatin-binding protein 1alpha, demethylation of nucleosomal histone H3 lysine 9 (H3(Lys(9))), increased phosphorylation of the adjacent serine 10 (H3(Ser(10))), and recruitment of NF-kappaB RelA/p65 to the TNFalpha promoter.	Lysine	187-193	tumor necrosis factor	Homo sapiens	19-27
17636263-3	2007	Removal of this bond in thrombin produces an approximately 100-fold loss of activity toward several chromogenic and natural substrates carrying Arg or Lys at P1.	Lysine	151-154	coagulation factor II, thrombin	Homo sapiens	24-32
17785715-3	2007	A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs.	Lysine	102-105	toll like receptor 2	Homo sapiens	113-117
17646159-4	2007	We found increased TNFalpha mRNA levels in endotoxin-responsive cells that was preceded by dissociation of heterochromatin-binding protein 1alpha, demethylation of nucleosomal histone H3 lysine 9 (H3(Lys(9))), increased phosphorylation of the adjacent serine 10 (H3(Ser(10))), and recruitment of NF-kappaB RelA/p65 to the TNFalpha promoter.	Lysine	200-203	tumor necrosis factor	Homo sapiens	19-27
17646165-3	2007	We demonstrated that Ubc9, the E2 component of the sumoylation machinery, specifically interacts with the N-terminal domain of GCMa and promotes GCMa sumoylation on lysine 156.	Lysine	165-171	lesswright	Drosophila melanogaster	21-25
17805299-8	2007	These observations show that p53 is dynamically regulated by lysine methylation and demethylation and that the methylation status at a single lysine residue confers distinct regulatory output.	Lysine	61-67	tumor protein p53	Homo sapiens	29-32
17805299-8	2007	These observations show that p53 is dynamically regulated by lysine methylation and demethylation and that the methylation status at a single lysine residue confers distinct regulatory output.	Lysine	142-148	tumor protein p53	Homo sapiens	29-32
17803944-3	2007	Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --&gt; lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3.	Lysine	110-116	Blm10p	Saccharomyces cerevisiae S288C	190-195
17805299-1	2007	p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation.	Lysine	127-133	tumor protein p53	Homo sapiens	0-3
17785715-3	2007	A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs.	Lysine	102-105	interferon gamma	Homo sapiens	186-202
17785715-3	2007	A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs.	Lysine	102-105	interferon gamma	Homo sapiens	204-213
17785715-3	2007	A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs.	Lysine	102-105	toll like receptor 1	Homo sapiens	250-254
17537656-2	2007	The predicted prepro-NPY peptide contained a putative signal peptide of 28 amino acids and a mature NPY of 36 amino acids, followed by the proteolytic processing site Gly-Lys-Arg and 35 amino acids that comprise the C-terminal peptide of NPY.	Lysine	171-174	neuropeptide Y	Rattus norvegicus	21-24
17701905-4	2007	In addition, we have detected a heterozygous transition (c.481G--&gt;A) in exon 3 of CHMP4B cosegregating with autosomal dominant posterior polar cataracts in a Japanese family that was predicted to result in the missense substitution of lysine for a conserved glutamic acid residue at codon 161 (p.E161K).	Lysine	238-244	charged multivesicular body protein 4B	Homo sapiens	85-91
17468230-3	2007	We evaluated the contributions of hydrophobic residues throughout Tbeta4, the conserved and variable proline residues, and the conserved lysine residues to the kinetics and thermodynamics of Tbeta4 binding to MgATP-actin monomers.	Lysine	137-143	thymosin beta 4 X-linked	Homo sapiens	191-197
17567947-2	2007	The studied thymosin beta(4) variants included substitutions of the lysine residues within the basic cluster (14-KSKLKK-19) and the actin-binding motif (17-LKKTETQ-23).	Lysine	68-74	thymosin beta 4 X-linked	Homo sapiens	12-28
17696781-4	2007	We report here that the slower migrating form is the result of sumoylation at a single lysine residue within the transcriptional activation domain of ZXDC.	Lysine	87-93	ZXD family zinc finger C	Homo sapiens	150-154
18690035-2	2007	Our recent findings suggest that PIP(2) gating and pH gating are controlled by an intra-subunit H-bond at the helix-bundle crossing between a lysine in TM1 and a backbone carbonyl group in TM2.	Lysine	142-148	prolactin induced protein	Homo sapiens	33-36
17425675-4	2007	The high lysine content of both proteins and an RNA binding motif in the Nop6p amino acid sequence suggest RNA-binding functions for both factors.	Lysine	9-15	Nop6p	Saccharomyces cerevisiae S288C	73-78
17938767-7	2007	TAFIa, the product of TAFI activation, removes lysine residues from fibrin, which are essential for the binding of t-PA, plasminogen, and plasmin to fibrin.	Lysine	47-53	plasminogen activator, tissue type	Homo sapiens	115-119
17606597-9	2007	We determined two unique N-terminal lysines (K62 and K75) in serogroup O8 YopE, not present in serogroup O9 YopE, that served as polyubiquitin acceptor sites.	Lysine	36-43	yopE	Yersinia enterocolitica	74-78
17606597-10	2007	Insertion of either lysine in serotype O9 YopE enabled its ubiquitination and destabilization.	Lysine	20-26	yopE	Yersinia enterocolitica	42-46
17694090-6	2007	One of the key factors that might have contributed to this preservation is the intimate relationship between some members of this group of proteins (SirT1, SirT2 and SirT3) and deacetylation of a specific residue in histone H4, lysine 16 (H4K16).	Lysine	228-234	sirtuin 3	Homo sapiens	166-171
17580098-2	2007	(Ala(2,8,9,19,24.25.27), Nle(17), Lys(28))VIP, (A-NL-K)VIP, was synthesized and Lys(28) was coupled to a linker, N-methyl-amino-ethyl-glycine, L2, which formed a carbamate bond with CPT.	Lysine	34-37	vasoactive intestinal polypeptide	Mus musculus	42-45
17580098-2	2007	(Ala(2,8,9,19,24.25.27), Nle(17), Lys(28))VIP, (A-NL-K)VIP, was synthesized and Lys(28) was coupled to a linker, N-methyl-amino-ethyl-glycine, L2, which formed a carbamate bond with CPT.	Lysine	80-83	vasoactive intestinal polypeptide	Mus musculus	42-45
17580098-2	2007	(Ala(2,8,9,19,24.25.27), Nle(17), Lys(28))VIP, (A-NL-K)VIP, was synthesized and Lys(28) was coupled to a linker, N-methyl-amino-ethyl-glycine, L2, which formed a carbamate bond with CPT.	Lysine	80-83	vasoactive intestinal polypeptide	Mus musculus	55-58
17685644-0	2007	Effects of mutational (Lys to Ala) surface charge changes on the redox properties of electrode-immobilized cytochrome c.	Lysine	23-26	cytochrome c, somatic	Homo sapiens	107-119
17685644-1	2007	Untrimethylated yeast iso-1-cytochrome c (cytc) and its single and multiple Lys to Ala variants at the surface lysines 72, 73, and 79 were adsorbed on carboxyalkanethiol self-assembled monolayers (SAMs) on gold, and the thermodynamics and kinetics of the heterogeneous protein-electrode electron-transfer (ET) reaction were determined by voltammetry.	Lysine	111-118	cytochrome c, somatic	Homo sapiens	28-40
17707234-4	2007	We find that SET8 specifically monomethylates p53 at lysine 382 (p53K382me1).	Lysine	53-59	tumor protein p53	Homo sapiens	46-49
17699856-6	2007	Silencing of PRDM5 was mediated by either DNA methylation or trimethylation of Lys(27) of histone H3.	Lysine	79-82	PR/SET domain 5	Homo sapiens	13-18
17699856-9	2007	CONCLUSIONS: Our data suggest that epigenetic alteration of PRDM5 (e.g., methylation of its 5"-CpG island or trimethylation of Lys(27) of histone H3) likely plays a key role in the progression of gastrointestinal cancers and may be a useful molecular marker.	Lysine	127-130	PR/SET domain 5	Homo sapiens	60-65
17707234-0	2007	Modulation of p53 function by SET8-mediated methylation at lysine 382.	Lysine	59-65	tumor protein p53	Homo sapiens	14-17
20641724-16	2004	showed that the kidney uptake of a short linear DOTA-alpha-MSH analog (DOTA-NAPamide) could be considerably reduced by neutralizing the charge of the Lys(11) residue.	Lysine	150-153	proopiomelanocortin	Homo sapiens	53-62
17660709-9	2007	Immunofluorescence microscopy revealed that HT2 mAb stained the perinuclear cytoplasm of ER-stressed HeLa cells, which was similar to the staining pattern with anti-KDEL (Lys-Asp-Glu-Leu) mAb that recognizes the ER.	Lysine	171-174	hypothermia due to alcohol sensitivity 2	Mus musculus	44-47
17544373-5	2007	Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus.	Lysine	153-159	cyclin dependent kinase inhibitor 2A	Homo sapiens	181-184
17628030-6	2007	The albumin-bound form of the prodrug was shown to be efficiently cleaved by cathepsin B and plasmin as well as in an ovarian carcinoma homogenate (OVCAR-3) liberating a methotrexate-lysine derivative.	Lysine	183-189	albumin	Homo sapiens	4-11
17561456-1	2007	We have previously produced two bioactive lysine-deficient mutants of TNF-alpha (mutTNF-K90R,-K90P) and found that these mutants have bioactivity superior to wild-type TNF (wtTNF).	Lysine	42-48	tumor necrosis factor	Homo sapiens	70-79
17561456-1	2007	We have previously produced two bioactive lysine-deficient mutants of TNF-alpha (mutTNF-K90R,-K90P) and found that these mutants have bioactivity superior to wild-type TNF (wtTNF).	Lysine	42-48	tumor necrosis factor	Homo sapiens	70-73
17517433-10	2007	The ERM domain of STIM1 binds to TRPC channels and a lysine-rich region participates in the gating of SOCs and TRPC1.	Lysine	53-59	stromal interaction molecule 1	Homo sapiens	18-23
17881328-2	2007	It differs from human insulin in that the amino acid threonine in position B30 has been removed and a 14-carbon fatty acid (myristic acid) has been acylated to lysine at B29.	Lysine	160-166	insulin	Homo sapiens	22-29
17483134-3	2007	Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail.	Lysine	142-148	sialic acid binding Ig like lectin 15	Homo sapiens	0-9
17483134-6	2007	Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule.	Lysine	108-114	sialic acid binding Ig like lectin 15	Homo sapiens	0-9
17483134-6	2007	Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule.	Lysine	108-114	hematopoietic cell signal transducer	Homo sapiens	94-99
17503466-3	2007	The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a conserved lysine residue with a serine.	Lysine	119-125	voltage-dependent anion channel 1	Mus musculus	29-34
17503466-3	2007	The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a conserved lysine residue with a serine.	Lysine	119-125	voltage-dependent anion channel 1	Mus musculus	36-42
17553927-6	2007	Finally, we show that down-regulation of Gap1 caused by lack of SL biogenesis involves the ubiquitination of the protein on lysines normally not accessible to ubiquitination and close to the membrane.	Lysine	124-131	amino acid permease GAP1	Saccharomyces cerevisiae S288C	41-45
17582505-1	2007	Transglutaminase 2 (TG2) is a multi-domain, multi-functional enzyme that post-translationally modifies proteins by catalyzing the formation of intermolecular isopeptide bonds between glutamine and lysine side-chains.	Lysine	197-203	transglutaminase 2	Homo sapiens	0-18
17582505-1	2007	Transglutaminase 2 (TG2) is a multi-domain, multi-functional enzyme that post-translationally modifies proteins by catalyzing the formation of intermolecular isopeptide bonds between glutamine and lysine side-chains.	Lysine	197-203	transglutaminase 2	Homo sapiens	20-23
17678539-5	2007	However, due to the distinct characteristics of A12L proteolysis such as the localization of both the A12L full-length protein and its cleavage product in mature virions and two putative cleavage sites (Ala-Gly-Lys) located at internal and C-terminal region of A12L ORF, it was of interest to examine the A12L proteolysis for better understanding of regulation and function of VV proteolysis.	Lysine	211-214	core protein	Vaccinia virus	48-52
17658762-6	2007	These adducts could have significant effects considering that His-33, Lys-72, and Lys-100 are present in clusters of basic amino acid residues, which are believed to participate in the interaction of cytochrome c with cardiolipin in the inner mitochondrial membrane and cytochrome c oxidase.	Lysine	70-73	cytochrome c, somatic	Homo sapiens	200-212
17658762-6	2007	These adducts could have significant effects considering that His-33, Lys-72, and Lys-100 are present in clusters of basic amino acid residues, which are believed to participate in the interaction of cytochrome c with cardiolipin in the inner mitochondrial membrane and cytochrome c oxidase.	Lysine	82-85	cytochrome c, somatic	Homo sapiens	200-212
17658762-6	2007	These adducts could have significant effects considering that His-33, Lys-72, and Lys-100 are present in clusters of basic amino acid residues, which are believed to participate in the interaction of cytochrome c with cardiolipin in the inner mitochondrial membrane and cytochrome c oxidase.	Lysine	82-85	cytochrome c, somatic	Homo sapiens	270-282
17553875-4	2007	An in vitro cleavage assay revealed that cathepsin L cleaves the capsid protein between amino acid residues Lys(18) and Arg(19), which are well conserved among the mosquito-borne flaviviruses.	Lysine	108-111	cathepsin L	Homo sapiens	41-52
17548468-4	2007	Here we report that the small ubiquitin-like protein SUMO-1 can modify MafB in vitro and in vivo on lysines 32 and 297.	Lysine	100-107	MAF bZIP transcription factor B	Homo sapiens	71-75
17592039-6	2007	Deletion of the TUC1 gene together with a deletion of the ELP3 gene, which results in the lack of the mcm(5) side chain, removes all modifications from the wobble uridine derivatives of the cytoplasmic tRNAs specific for Gln, Lys, and Glu, and is lethal to the cell.	Lysine	226-229	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	58-62
17662948-5	2007	Mutation of two specific lysine residues in the C-terminal region of Pax3 reduced the extent of its monoubiquitination and susceptibility to proteasomal degradation, whereas introduction of a key lysine into the C-terminal region of Pax7 rendered that protein susceptible to monoubiquitination and proteasomal degradation.	Lysine	25-31	paired box 3	Homo sapiens	69-73
17614368-3	2007	In the present study, we examined whether ubiquitination of presenilin-2 (PS2) is required for interaction with ubiquilin-1 by mutating lysine residues that may be targets for ubiquitination in the presenilin loop and carboxyl terminus regions.	Lysine	136-142	presenilin 2	Homo sapiens	60-72
17614368-4	2007	Mutation of two lysine residues in the PS2-loop region suggested that ubiquitination is not required for interaction with ubiquilin-1 and may, in fact, even negatively regulate the interaction.	Lysine	16-22	presenilin 2	Homo sapiens	39-42
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Lysine	61-67	presenilin 2	Homo sapiens	105-108
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Lysine	61-67	presenilin 2	Homo sapiens	224-227
17652514-2	2007	Whereas suppressor of variegation 3-9 [SU(VAR)3-9], a histone methyltransferase, is mainly responsible for lysine 9 of histone H3 (H3K9) methylation of the chromocenter and consequent binding of the heterochromatin-protein HP1, the enzyme for painting of the fourth chromosome by H3K9 methylation has been elusive.	Lysine	107-113	Suppressor of variegation 205	Drosophila melanogaster	223-226
17662948-5	2007	Mutation of two specific lysine residues in the C-terminal region of Pax3 reduced the extent of its monoubiquitination and susceptibility to proteasomal degradation, whereas introduction of a key lysine into the C-terminal region of Pax7 rendered that protein susceptible to monoubiquitination and proteasomal degradation.	Lysine	196-202	paired box 3	Homo sapiens	69-73
17478422-9	2007	Mutation of the three key lysine residues did not alter the stability of Smad2 or the ability of Smad2 to form a complex with Smad4 on promoter DNA, but it prevented nuclear accumulation of Smad2 and subsequent TGFbeta and activin responses.	Lysine	26-32	transforming growth factor beta 1	Homo sapiens	211-218
17673261-3	2007	TG2 may catalyze the replacement reaction between Lys residues in protein and polyamines.	Lysine	50-53	transglutaminase 2	Homo sapiens	0-3
17643371-4	2007	Trimethylated histone H3 lysine 9 (H3-K9) was found to associate with the histone trimethyltransferase Suv39h1 and DNA methyltransferase Dnmt3a in the methylated 14-3-3sigma locus.	Lysine	25-31	SUV39H1 histone lysine methyltransferase	Homo sapiens	103-110
17452463-7	2007	Through both in vitro and in vivo assays, we identified lysine 44 of CDK9 as a major acetylation site.	Lysine	56-62	cyclin dependent kinase 9	Homo sapiens	69-73
17590016-1	2007	The transcriptional coactivator paralogues p300 and CBP contain acetyltransferase domains (HAT) and catalyze the lysine acetylation of histones and other proteins as an important aspect of their functions.	Lysine	113-119	CREB binding protein	Homo sapiens	52-55
17452329-8	2007	1) Arg-containing HNP1 and (Lys--&gt;Arg)hBD1 are functionally better than Lys-HNP1 and hBD1, respectively; the difference between Arg and Lys is more evident in the alpha-defensin than in the beta-defensin and is more evident at low salt concentrations than at high salt concentrations.	Lysine	28-31	defensin beta 1	Homo sapiens	41-45
18051779-1	2007	INTRODUCTION: The non-enzymatic glycation of Low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and glucose.	Lysine	178-184	apolipoprotein B	Homo sapiens	125-141
17580963-6	2007	Acrolein caused oxidative modification of apoE3-NT as detected by Western blot with acrolein-lysine-specific antibodies, and tertiary conformational alterations.	Lysine	93-99	apolipoprotein E	Homo sapiens	42-47
17630506-1	2007	p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation.	Lysine	33-40	tumor protein p53	Homo sapiens	0-3
17630506-1	2007	p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation.	Lysine	33-40	tumor protein p53	Homo sapiens	131-134
17481605-3	2007	The fMLP-OMe analogues synthesized, with the general formula for-Met-Leu-Phe-Xaa-Lys(OMe)-Phe-Leu-Met-for (Xaa=Gly, beta-Ala, gamma-aminobutyric acid, 5-aminovaleric acid, and 6-aminocaproic acid), were constituted by two fMLP units linked by a Lys residue, with an amino acid spacer between them.	Lysine	81-84	formyl peptide receptor 1	Homo sapiens	4-8
17495236-4	2007	Chromatin immunoprecipitation (ChIP) assays showed that Ang II increased Histone H3 Lysine (K9/14) acetylation on the IL-6 promoter.	Lysine	84-90	angiotensinogen	Rattus norvegicus	56-62
17495236-4	2007	Chromatin immunoprecipitation (ChIP) assays showed that Ang II increased Histone H3 Lysine (K9/14) acetylation on the IL-6 promoter.	Lysine	84-90	keratin 9	Rattus norvegicus	92-97
17495236-4	2007	Chromatin immunoprecipitation (ChIP) assays showed that Ang II increased Histone H3 Lysine (K9/14) acetylation on the IL-6 promoter.	Lysine	84-90	interleukin 6	Rattus norvegicus	118-122
17616667-4	2007	Regardless of transcriptional status, the Snail promoter displays three constitutive DNase hypersensitive sites (HS) and a moderate level of histone H3 Lys(4) dimethylation.	Lysine	152-155	snail family transcriptional repressor 1	Homo sapiens	42-47
17601884-1	2007	The collagenous region of adiponectin is glycosylated in vitro with glucosylgalactosyl moieties on four conserved lysines.	Lysine	114-121	adiponectin, C1Q and collagen domain containing	Homo sapiens	26-37
17604720-5	2007	HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus.	Lysine	109-115	homeobox D cluster	Homo sapiens	137-141
17559584-2	2007	This allele is identical to the HLA-B*3308 allele except for one point mutation in exon 2 at codon 66 (AAA--&gt;AAT), resulting in an amino acid change from lysine (K) to asparagine (N).	Lysine	157-163	serpin family A member 1	Homo sapiens	112-115
17426036-6	2007	Using the dimeric E2, UbcH13/Uev1a, they attach Lys(63) chains, but with UbcH1 (E2-25K), MuRF1 synthesizes Lys(48) chains on the substrate.	Lysine	107-110	tripartite motif containing 63	Homo sapiens	89-94
17477906-3	2007	A mutant p21(Cip1) in which all six lysines were changed to arginines was protected against H(2)O(2) treatment.	Lysine	36-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	13-17
17442499-1	2007	Nardilysin is a metalloendopeptidase that in vitro cleaves peptides such as dynorphin-A, somatostatin-28, alpha-neoendorphin and glucagon at the N-terminus of arginine and lysine residues in dibasic moieties.	Lysine	172-178	nardilysin convertase	Homo sapiens	0-10
17565699-4	2007	Analysis of the effect of NF90ctv-TAR RNA interaction in vivo showed significant inhibition of Tat-transactivation of HIV-1 LTR in cells expressing NF90ctv, as well as changes in histone H3 lysine-4 and lysine-9 methylation of HIV chromatin that are consistent with the epigenetic changes in transcriptionally repressed gene.	Lysine	190-196	RNA binding motif protein 8A	Homo sapiens	34-37
17565699-4	2007	Analysis of the effect of NF90ctv-TAR RNA interaction in vivo showed significant inhibition of Tat-transactivation of HIV-1 LTR in cells expressing NF90ctv, as well as changes in histone H3 lysine-4 and lysine-9 methylation of HIV chromatin that are consistent with the epigenetic changes in transcriptionally repressed gene.	Lysine	203-209	RNA binding motif protein 8A	Homo sapiens	34-37
17449468-5	2007	The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively.	Lysine	61-64	tumor necrosis factor	Homo sapiens	219-222
17449468-5	2007	The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively.	Lysine	61-64	nuclear factor kappa B subunit 1	Homo sapiens	241-250
17327486-6	2007	The kinin agonists BK and Lys-des[Arg(9)]-BK up-regulated the expression of their respective receptors.	Lysine	26-29	kininogen 1	Homo sapiens	42-44
17573780-0	2007	RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.	Lysine	76-82	retinol binding protein 2	Homo sapiens	0-4
17213811-8	2007	Additionally, silenced Ep-CAM gene in cancer cells was enriched for hypermethylated histone 3 lysine 9.	Lysine	94-100	epithelial cell adhesion molecule	Homo sapiens	23-29
17466390-6	2007	Desensitization was impaired by the nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC) and PKG inhibitors L-NAME, LY 83583 and KT5823, respectively, indicating that homologous desensitization of TP alpha involves nitric oxide generation and signalling.	Lysine	123-125	nitric oxide synthase 2	Homo sapiens	36-57
17466390-6	2007	Desensitization was impaired by the nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC) and PKG inhibitors L-NAME, LY 83583 and KT5823, respectively, indicating that homologous desensitization of TP alpha involves nitric oxide generation and signalling.	Lysine	123-125	plasminogen activator, tissue type	Homo sapiens	204-212
17534149-6	2007	We and others have recently identified a novel modification on p53, acetylation of lysine 120 within the DNA binding domain.	Lysine	83-89	tumor protein p53	Homo sapiens	63-66
17534149-8	2007	We demonstrate here that both the DNA damage response pathway and the p19ARF/oncogene stress pathway induce the acetylation of p53 at lysine 120.	Lysine	134-140	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-76
17534149-8	2007	We demonstrate here that both the DNA damage response pathway and the p19ARF/oncogene stress pathway induce the acetylation of p53 at lysine 120.	Lysine	134-140	tumor protein p53	Homo sapiens	127-130
17371849-6	2007	Increased expression of Nppb and Nppa correlates with increased histone H4 acetylation and histone H3 lysine 4 methylation of promoter-proximal regions of these genes.	Lysine	102-108	natriuretic peptide B	Rattus norvegicus	24-28
17428000-5	2007	In this study, we generated a chemically modified human growth hormone (hGH) by incorporation of a palmitoyl moiety on the N(epsilon) group of a lysine residue.	Lysine	145-151	growth hormone 1	Homo sapiens	56-70
17471463-10	2007	Interestingly, TMS1 promoter methylation-associated gene silencing was accompanied by histone H3 Lysine 9 (H3K9) hypoacetylation and trimethylation.	Lysine	97-103	PYD and CARD domain containing	Homo sapiens	15-19
17510366-2	2007	RNA polymerase II signals for deacetylation through the methylation of histone H3 lysine 36 (H3K36), which provides the recruitment signal for the Rpd3S histone deacetylase complex (HDAC).	Lysine	82-88	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	147-151
17542650-6	2007	Previous studies have shown that SETDB1 can trimethylate H3 on lysine 9, using in vitro or artificial tethering assays.	Lysine	63-69	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	33-39
17474717-6	2007	Here we show that 4 lysine residues (Lys8 or -13, Lys86 or -87, Lys99, and Lys100) of cytochrome c are susceptible to N-homocysteinylation.	Lysine	20-26	cytochrome c, somatic	Homo sapiens	86-98
17474717-7	2007	We also show that N-homocysteinylation of 1 mol of lysine/mol of protein affects the redox state of the heme ligand of cytochrome c by rendering it reduced.	Lysine	51-57	cytochrome c, somatic	Homo sapiens	119-131
17502423-0	2007	Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.	Lysine	40-46	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	124-127
17502423-4	2007	In total, our data demonstrate that mK3-mediated ubiquitination can occur via serine, threonine, or lysine residues on the HC tail, each of which is sufficient to induce the rapid degradation of HC.	Lysine	100-106	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	36-39
17389749-4	2007	This Ser (S78) is adjacent to several positively charged residues (Arg or Lys), which we show here are involved in nuclear localization of HNF4alpha and are conserved in nearly all other NRs, along with the Ser/threonine (Thr).	Lysine	74-77	hepatocyte nuclear factor 4 alpha	Homo sapiens	139-148
17418100-3	2007	One of the mitogen-activated protein kinase kinase kinses (MAP3Ks) members, TAK1, plays a critical role in cytokine-induced activation of NFkappaB, which involves lysine 63-linked (K63) polyubiquitination of NEMO, a noncatalytic subunit of the IkappaB kinase complex.	Lysine	163-169	nuclear factor kappa B subunit 1	Homo sapiens	138-146
17355966-7	2007	In vitro assays demonstrate that the Set1B complex is a histone methyltransferase that produces trimethylated histone H3 at Lys(4).	Lysine	124-127	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	37-42
17428436-4	2007	All analogues demonstrated a decreased potency in cAMP production (EC(50) 1.47 to 11.02 nM; p&lt;0.01 to p&lt;0.001) with (Lys(3))GIP and (Phe(3))GIP significantly inhibiting GIP-stimulated cAMP production (p&lt;0.05).	Lysine	123-126	gastric inhibitory polypeptide	Rattus norvegicus	130-133
17428436-5	2007	In BRIN-BD11 cells, (Lys(3))GIP, (Phe(3))GIP, (Trp(3))GIP and (Tyr(3))GIP did not stimulate insulin secretion with both (Lys(3))GIP and (Phe(3))GIP significantly inhibiting GIP-stimulated insulin secretion (p&lt;0.05).	Lysine	21-24	gastric inhibitory polypeptide	Rattus norvegicus	28-31
17371868-5	2007	Mutant p53 ubiquitination occurred at lysines in both the DNA-binding domain (DBD) and C terminus.	Lysine	38-45	tumor protein p53	Homo sapiens	7-10
17371868-6	2007	Interestingly, Lys to Arg mutations that inhibited ubiquitination restored nuclear localization to mutant p53 but had no apparent effect on p53 conformation.	Lysine	15-18	tumor protein p53	Homo sapiens	106-109
17353187-6	2007	HSCO specifically associates with histone deacetylase 1 (HDAC1) independently of Mdm2 and facilitates deacetylation of p53 at Lys-373/382 by HDAC1.	Lysine	126-129	histone deacetylase 1	Homo sapiens	34-55
17353187-6	2007	HSCO specifically associates with histone deacetylase 1 (HDAC1) independently of Mdm2 and facilitates deacetylation of p53 at Lys-373/382 by HDAC1.	Lysine	126-129	histone deacetylase 1	Homo sapiens	57-62
17353187-6	2007	HSCO specifically associates with histone deacetylase 1 (HDAC1) independently of Mdm2 and facilitates deacetylation of p53 at Lys-373/382 by HDAC1.	Lysine	126-129	tumor protein p53	Homo sapiens	119-122
17353187-6	2007	HSCO specifically associates with histone deacetylase 1 (HDAC1) independently of Mdm2 and facilitates deacetylation of p53 at Lys-373/382 by HDAC1.	Lysine	126-129	histone deacetylase 1	Homo sapiens	141-146
17428436-2	2007	Here we report the enzyme resistance and biological activity of several Glu(3)-substituted analogues of GIP namely; (Ala(3))GIP, (Lys(3))GIP, (Phe(3))GIP, (Trp(3))GIP and (Tyr(3))GIP.	Lysine	130-133	gastric inhibitory polypeptide	Rattus norvegicus	104-107
17353273-4	2007	We have identified lysine 288 as the major sumoylation site of YY1.	Lysine	19-25	YY1 transcription factor	Homo sapiens	63-66
17478130-4	2007	We show that long chain acyl-CoA synthetase 1 is acetylated at both the N-terminal end and at a lysine residue and tyrosine residues are found to be phosphorylated and nitrated.	Lysine	96-102	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	13-45
17074388-2	2007	The p15 CpG island region was surrounded with both the acetylated histone H3 (AcH3) and dimethylated histone H3-lysine 9 (MeH3K9) in bone marrow cells of AML patients, whereas with AcH3 alone in normal marrow cells.	Lysine	112-118	cyclin dependent kinase inhibitor 2B	Homo sapiens	4-7
17251325-0	2007	Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5.	Lysine	116-123	solute carrier family 4 member 4	Homo sapiens	99-106
17428030-6	2007	Coacervation of the VEGF-bound dextran sulfate with selected polycations (chitosan, polyethylenimine, or poly-L-lysine) produced nanoparticles approximately 250 nm in diameter with high VEGF encapsulation efficiency (50-85%).	Lysine	105-118	vascular endothelial growth factor A	Homo sapiens	20-24
17428030-6	2007	Coacervation of the VEGF-bound dextran sulfate with selected polycations (chitosan, polyethylenimine, or poly-L-lysine) produced nanoparticles approximately 250 nm in diameter with high VEGF encapsulation efficiency (50-85%).	Lysine	105-118	vascular endothelial growth factor A	Homo sapiens	186-190
17301132-9	2007	Codons for methionine, lysine, histidine, or glutamic acid are found prior to the Gag-Pol frameshift site.	Lysine	23-29	Gag-Pol	Human immunodeficiency virus 1	82-89
17267393-5	2007	We confirmed, by in vitro labeling and peptide mapping by mass spectrometry, that two previously known acetyltransferases, p300 and CREB-binding protein, could catalyze lysine propionylation and lysine butyrylation in histones.	Lysine	169-175	CREB binding protein	Homo sapiens	132-152
17267393-5	2007	We confirmed, by in vitro labeling and peptide mapping by mass spectrometry, that two previously known acetyltransferases, p300 and CREB-binding protein, could catalyze lysine propionylation and lysine butyrylation in histones.	Lysine	195-201	CREB binding protein	Homo sapiens	132-152
17427264-3	2007	A Maillard reaction mixture (25 mM D-ribose/L-lysine, 30 min at 120 degrees C) increased NF-kappaB translocation 18-fold (in PBS) or six-fold (in medium).	Lysine	44-52	nuclear factor kappa B subunit 1	Homo sapiens	89-98
17347654-5	2007	Moreover, we identify the sumoylation site Lys-388 of PR as the target of CUEDC2-promoted ubiquitination.	Lysine	43-46	CUE domain containing 2	Homo sapiens	74-80
17447102-8	2007	Finally, by comparing gene expression changes in the htb1 ( K123R ) strain with those in a strain deleted for rad6, we conclude that lysine 123 affects transcription primarily because of it being a site of ubiquitylation.	Lysine	133-139	histone H2B	Saccharomyces cerevisiae S288C	53-57
17374386-3	2007	This review (written in the early 2006) described structural aspects of methylation of histone lysine residues by two enzyme families with entirely different structural scaffolding (the SET proteins and Dot1p), and the protein motifs that recognize (decode) these methyl-lysine signals.	Lysine	95-101	DOT1 like histone lysine methyltransferase	Homo sapiens	203-208
17389990-1	2007	Horse spleen apoferritin, the hollow protein shell derived from ferritin, a special biological nanoparticle, can be chemoselectively modified at the lysine residues, which affords a robust scaffold for further chemical reactions including Cu(i)-catalyzed azide-alkyne cycloaddition reaction and atom transfer radical polymerization reaction.	Lysine	149-155	ferritin heavy chain	Equus caballus	13-24
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	83-89	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	156-159	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	166-169	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	166-169	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	166-169	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	166-169	tripartite motif containing 28	Homo sapiens	64-72
17298944-3	2007	A combined analysis of deletion and punctual mutants identified TIF1beta as a multilysine acceptor for SUMO which specifically targets six lysine residues (Lys(554), Lys(575), Lys(676), Lys(750), Lys(779), and Lys(804)) within the TIF1beta C-terminal repressive region.	Lysine	166-169	tripartite motif containing 28	Homo sapiens	64-72
17298944-6	2007	TIF1beta homodimerization properties and interaction with the KRAB domain are preserved in the mutants with lysine to arginine substitutions as confirmed by in vivo bioluminescence resonance energy transfer (BRET).	Lysine	108-114	tripartite motif containing 28	Homo sapiens	0-8
17307730-7	2007	Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age-related increase in p53 expression, and increased the rate of p53 degradation.	Lysine	77-83	tumor protein p53	Homo sapiens	50-53
17307730-7	2007	Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age-related increase in p53 expression, and increased the rate of p53 degradation.	Lysine	77-83	tumor protein p53	Homo sapiens	146-149
17307730-7	2007	Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age-related increase in p53 expression, and increased the rate of p53 degradation.	Lysine	77-83	tumor protein p53	Homo sapiens	146-149
17347654-6	2007	CUEDC2 decreases the sumoylation while promoting ubiquitination on Lys-388 of PRB.	Lysine	67-70	CUE domain containing 2	Homo sapiens	0-6
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Lysine	80-86	endothelin 1	Homo sapiens	124-136
17389369-7	2007	Comparison of two crystal structures of the Skp1-Fbs1 complex revealed the relative motion of a linker segment between the F-box and the SBD domains, which might underlie the ability of the complex to recognize different acceptor lysine residues for ubiquitination.	Lysine	230-236	F-box protein 2	Homo sapiens	49-53
17389396-3	2007	In addition to members of the Set1 complex that mediate histone H3 lysine 4 methylation (H3K4me), we found that deleting members of the CCR4/NOT mRNA processing complex exhibit synthetic phenotypes when combined with proteasome mutants.	Lysine	67-73	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	30-34
17413098-10	2007	CONCLUSION: A mixture of leucine, isoleucine, valine, lysine, and threonine resulted in glycemic and insulinemic responses closely mimicking those seen after whey ingestion in the absence of an additional effect of GIP and glucagon-like peptide 1.	Lysine	54-60	gastric inhibitory polypeptide	Homo sapiens	215-218
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Lysine	80-86	endothelin 1	Homo sapiens	138-142
17413098-10	2007	CONCLUSION: A mixture of leucine, isoleucine, valine, lysine, and threonine resulted in glycemic and insulinemic responses closely mimicking those seen after whey ingestion in the absence of an additional effect of GIP and glucagon-like peptide 1.	Lysine	54-60	glucagon	Homo sapiens	223-246
17510493-6	2007	In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects.	Lysine	46-54	chromogranin A	Homo sapiens	122-136
17310239-5	2007	Ubc7 is autoubiquitinated by a novel mechanism wherein the catalytic cysteine, instead of a lysine residue, provides the polyubiquitin chain acceptor site, and this cysteine-linked chain functions as a degradation signal.	Lysine	92-98	E2 ubiquitin-conjugating protein UBC7	Saccharomyces cerevisiae S288C	0-4
17244610-6	2007	Mutation of this Lys plus four additional residues, predicted to be neighbors in an assumed alpha-helical TMD arrangement, abrogated the TAP2-stabilizing capacity of Tpn.	Lysine	17-20	TAP binding protein	Mus musculus	166-169
17390403-6	2007	In order to evaluate the nutritional quality of a protein, the concomitant analysis of free - and nutritionally available - lysine and the amount of lysine reacted to form the respective MRP is essential, even for mildly processed foods.	Lysine	149-155	ATP binding cassette subfamily C member 1	Homo sapiens	187-190
17548299-2	2007	Besides, one lysine within histone H4(K20) has been shown to be methylated by specific histone lysine methyltransferase.	Lysine	13-19	keratin 20	Homo sapiens	38-41
17341815-0	2007	Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells.	Lysine	42-48	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	56-86
17289077-6	2007	The second site contains a lysine and arginine-rich motif that is highly conserved between the two T cyclins.	Lysine	27-33	cyclin T1	Homo sapiens	101-108
17227771-5	2007	Employing site-directed mutagenesis studies, we identified lysine residues 4432 and 4435 and arginine 4442 as key amino acids important for ectodomain shedding of LRP1B.	Lysine	59-65	LDL receptor related protein 1B	Homo sapiens	163-168
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	56-62	nuclear factor kappa B subunit 1	Homo sapiens	115-124
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	56-62	nuclear factor kappa B subunit 1	Homo sapiens	177-186
17335352-7	2007	HP1 target genes are also marked by the histone variant H3.3 and dimethylated histone 3 lysine 4 (H3K4me2), which are both typical of active chromatin.	Lysine	88-94	Suppressor of variegation 205	Drosophila melanogaster	0-3
17259173-5	2007	Newborn brain from eed heterozygotes and eed;Mll double heterozygotes exhibited decreased trimethylation at lysine 27 of histone H3, as well as hyperacetylation of histone H4.	Lysine	108-114	lysine (K)-specific methyltransferase 2A	Mus musculus	45-48
17320161-0	2007	RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.	Lysine	76-82	eukaryotic translation initiation factor 4H1	Drosophila melanogaster	0-4
17320161-3	2007	Here we demonstrate that the JARID1 proteins RBP2, PLU1, and SMCX are histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4).	Lysine	136-142	eukaryotic translation initiation factor 4H1	Drosophila melanogaster	45-49
17229735-4	2007	Replacement of the two arginine residues in a Tat-specific precursor protein by lysine-glutamine resulted in an export-defective mutant precursor that was no longer accepted by the wild-type translocase.	Lysine	80-86	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	46-49
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	13-19	tumor necrosis factor	Homo sapiens	76-79
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	13-19	nuclear factor kappa B subunit 1	Homo sapiens	115-124
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	13-19	nuclear factor kappa B subunit 1	Homo sapiens	177-186
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	56-62	tumor necrosis factor	Homo sapiens	76-79
17327678-3	2007	The protonation of a hydrogen-bonded pair of lysines, Lys206 and Lys296, adjacent to the N-lobe iron site of Tf has been proposed to create a repulsive interaction that stimulates domain opening and iron release.	Lysine	45-52	transferrin	Homo sapiens	109-111
17341815-2	2007	We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level.	Lysine	86-92	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	106-112
17341815-3	2007	We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.	Lysine	33-36	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	87-93
17341815-3	2007	We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.	Lysine	42-45	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	87-93
17341815-3	2007	We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.	Lysine	42-45	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	87-93
17178770-10	2007	From these results, it is expected that CYP3A7 can recognize specific substrates using the lysines in F-G loops.	Lysine	91-98	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	40-46
17216278-4	2007	Glycation of apoA-I was quantified as the reduction in detectable arginine, lysine and tryptophan residues.	Lysine	76-82	apolipoprotein A1	Homo sapiens	13-19
17216278-9	2007	RESULTS: Methylglyoxal-mediated modifications of the arginine, lysine and tryptophan residues in lipid-free and lipid-associated apoA-I were time- and concentration-dependent.	Lysine	63-69	apolipoprotein A1	Homo sapiens	129-135
17267293-0	2007	Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae.	Lysine	26-32	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	39-44
17267293-2	2007	In particular, factors that are involved in the methylation of lysine-79 of histone H3 by Dot1p have been implicated in both processes, suggesting a bipartite function for this modification.	Lysine	63-69	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	90-95
17267293-3	2007	We find that a dot1 null mutation and a histone H3 point mutation at lysine-79 cause increased sensitivity to UV radiation, suggesting that lysine-79 methylation is important for efficient repair of UV damage.	Lysine	140-146	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	15-19
17267293-4	2007	Epistasis analysis between dot1 and various UV repair genes indicates that lysine-79 methylation plays overlapping roles within the nucleotide excision, post-replication and recombination repair pathways, as well as RAD9-mediated checkpoint function.	Lysine	75-81	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	27-31
17179081-7	2007	Partial spo1Delta complementation by PLB3 (encoding a unique PLB capable of cleaving PI) and relatively strong Spo1 binding to PI(4)P derivatives (via a novel N-terminal lysine-rich fragment essential for Spo1 function) are consistent with this view.	Lysine	170-176	putative carboxylic ester hydrolase	Saccharomyces cerevisiae S288C	111-115
17352742-6	2007	Chromatin immunoprecipitation assay revealed that histone H3 and H4 are highly acetylated, and H3 lysine (K) 4 is hypermethylated at the Nanog locus in ES cells.	Lysine	98-104	Nanog homeobox	Mus musculus	137-142
17328786-4	2007	In vivo studies in C57BL/6 mice showed that injection of DNA encoding ovalbumin (OVA) complexed to oxidized or reduced mannan-poly-L-lysine induced CD8 and CD4 T-cell responses as well as antibody responses leading to protection of mice from OVA+ tumours.	Lysine	126-139	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	70-79
17328786-4	2007	In vivo studies in C57BL/6 mice showed that injection of DNA encoding ovalbumin (OVA) complexed to oxidized or reduced mannan-poly-L-lysine induced CD8 and CD4 T-cell responses as well as antibody responses leading to protection of mice from OVA+ tumours.	Lysine	126-139	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	81-84
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Lysine	112-115	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Lysine	112-115	GLI family zinc finger 2	Homo sapiens	44-49
17081611-8	2007	Parotid saliva augmented IL-8 production of THP-1 cells stimulated with a synthetic TLR2 ligand, Pam(3)Cys-Ser-(Lys)(4) (Pam(3)CSK(4)).	Lysine	112-115	toll like receptor 2	Homo sapiens	84-88
16987993-3	2007	In this study, suspended gastric carcinoma cells showed higher basal and transforming growth factor-beta1 (TGFbeta1)-mediated acetylations of histone 3 (H3) and Lys(9) of H3 and levels of integrin-linked kinase (ILK) mRNA and protein than did fibronectin-adherent cells did.	Lysine	161-164	transforming growth factor beta 1	Homo sapiens	73-105
16924240-4	2007	Expression of ubiquitin derivatives with all lysines mutated except K48 or K63 demonstrated that K48-linked p53-ubiquitin conjugates were specifically induced after DNA damage.	Lysine	45-52	tumor protein p53	Homo sapiens	108-111
17135271-5	2007	Here we show that an intact RING domain of TRAF6 in conjunction with the E2 enzyme Ubc13/Uev1A is necessary for Lys-63-linked auto-ubiquitination of TRAF6 and for its ability to activate IKK and NF-kappaB.	Lysine	112-115	TNF receptor-associated factor 6	Mus musculus	43-48
17324262-6	2007	In some cervical cancer cell lines, these drugs led to increased transcription of p53, and increased its stabilization due to acetylation at lysines 273 and 282, which allowed a higher bax-protein transactivating effect.	Lysine	141-148	BCL2 associated X, apoptosis regulator	Homo sapiens	185-188
17121856-6	2007	Furthermore, the co-activator complexes initiate the recruitment of the components of the basal transcription apparatus to the basal promoter with markedly different outcomes because only Ac-Lys-373 p53 promotes the assembly of the basal transcriptional apparatus on the p21 promoter.	Lysine	191-194	tumor protein p53	Homo sapiens	199-202
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	163-166	kininogen 1	Homo sapiens	68-78
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	249-252	kininogen 1	Homo sapiens	68-78
17158446-6	2007	By varying time and the concentrations of lysine, Mg(2+), or LysRS, the adenylation of Hint was found to be dependent on the formation of lysyl-AMP.	Lysine	42-48	histidine triad nucleotide binding protein 1	Homo sapiens	87-91
17135271-5	2007	Here we show that an intact RING domain of TRAF6 in conjunction with the E2 enzyme Ubc13/Uev1A is necessary for Lys-63-linked auto-ubiquitination of TRAF6 and for its ability to activate IKK and NF-kappaB.	Lysine	112-115	TNF receptor-associated factor 6	Mus musculus	149-154
17135271-7	2007	Notably, we map the auto-ubiquitination site of TRAF6 to a single Lys residue, which if mutated renders TRAF6 unable to activate transforming growth factor-beta-activated kinase 1 and IKK and to cause spontaneous osteoclast differentiation.	Lysine	66-69	TNF receptor-associated factor 6	Mus musculus	48-53
17135271-7	2007	Notably, we map the auto-ubiquitination site of TRAF6 to a single Lys residue, which if mutated renders TRAF6 unable to activate transforming growth factor-beta-activated kinase 1 and IKK and to cause spontaneous osteoclast differentiation.	Lysine	66-69	TNF receptor-associated factor 6	Mus musculus	104-109
17135271-10	2007	These data establish a signaling cascade in which regulated site-specific Lys-63-linked TRAF6 auto-ubiquitination is the critical upstream mediator of IKK.	Lysine	74-77	TNF receptor-associated factor 6	Mus musculus	88-93
16987993-3	2007	In this study, suspended gastric carcinoma cells showed higher basal and transforming growth factor-beta1 (TGFbeta1)-mediated acetylations of histone 3 (H3) and Lys(9) of H3 and levels of integrin-linked kinase (ILK) mRNA and protein than did fibronectin-adherent cells did.	Lysine	161-164	transforming growth factor beta 1	Homo sapiens	107-115
16987993-7	2007	Chromatin immunoprecipitations with anti-acetylated H3, Lys(9)-acetylated H3, or p300/CBP antibody resulted in more coprecipitated ILK promoter, correlated with enhanced ILK mRNA and protein levels, in suspended cells.	Lysine	56-59	integrin linked kinase	Homo sapiens	131-134
16987993-7	2007	Chromatin immunoprecipitations with anti-acetylated H3, Lys(9)-acetylated H3, or p300/CBP antibody resulted in more coprecipitated ILK promoter, correlated with enhanced ILK mRNA and protein levels, in suspended cells.	Lysine	56-59	integrin linked kinase	Homo sapiens	170-173
17237426-4	2007	In the present study, we found that the fiber-modified Ad vector containing poly-lysine peptides in the fiber knob showed much lower serum IL-6 and aspartate aminotransferase levels (as a maker of liver toxicity) than the conventional Ad vector after i.v.	Lysine	81-87	interleukin 6	Homo sapiens	139-143
17064838-0	2007	A theoretical elucidation of bilirubin interaction with HSA"s lysines: first electrostatic binding site in IIA subdomain.	Lysine	62-69	albumin	Homo sapiens	56-59
17064838-1	2007	The electrostatic interaction of amino acid lysines 190, 195 and 199 of human serum albumin (HSA) with bilirubin have been investigated using molecular dynamic simulations, QM and QM/MM minimization methods.	Lysine	44-51	albumin	Homo sapiens	78-91
17064838-1	2007	The electrostatic interaction of amino acid lysines 190, 195 and 199 of human serum albumin (HSA) with bilirubin have been investigated using molecular dynamic simulations, QM and QM/MM minimization methods.	Lysine	44-51	albumin	Homo sapiens	93-96
17212354-0	2007	Histone H1-like, lysine-rich low complexity amino acid extensions in mosquito ribosomal proteins RpL23a and RpS6 have evolved independently.	Lysine	17-23	Ribosomal protein L23A	Drosophila melanogaster	97-103
17212354-4	2007	RpL23a proteins in Aedes and Anopheles mosquitoes are rich in lysine (approximately 25%), alanine (approximately 21%), and proline (approximately 8%), have a mass of approximately 40 kDa, a pI of 11.4 to 11.5, and contain an N-terminal extension of approximately 260 amino acid residues.	Lysine	62-68	Ribosomal protein L23A	Drosophila melanogaster	0-6
17245431-6	2007	In addition, DNA-bound CTIP2 also associates with the histone methyltransferase SUV39H1, which increases local histone H3 lysine 9 methylation.	Lysine	122-128	SUV39H1 histone lysine methyltransferase	Homo sapiens	80-87
17438944-2	2007	The erythropoietin (EPO) microparticles are using human serum albumin (HSA) and poly-L-lysine (PK) as the protection complex to increased EPO integrity, entrapped efficiency and active EPO release by w/o/w solvent evaporation techniques.	Lysine	80-93	erythropoietin	Homo sapiens	4-18
17438944-2	2007	The erythropoietin (EPO) microparticles are using human serum albumin (HSA) and poly-L-lysine (PK) as the protection complex to increased EPO integrity, entrapped efficiency and active EPO release by w/o/w solvent evaporation techniques.	Lysine	80-93	erythropoietin	Homo sapiens	20-23
17438944-2	2007	The erythropoietin (EPO) microparticles are using human serum albumin (HSA) and poly-L-lysine (PK) as the protection complex to increased EPO integrity, entrapped efficiency and active EPO release by w/o/w solvent evaporation techniques.	Lysine	80-93	erythropoietin	Homo sapiens	138-141
17438944-2	2007	The erythropoietin (EPO) microparticles are using human serum albumin (HSA) and poly-L-lysine (PK) as the protection complex to increased EPO integrity, entrapped efficiency and active EPO release by w/o/w solvent evaporation techniques.	Lysine	80-93	erythropoietin	Homo sapiens	138-141
17110383-6	2007	KLK14 displayed trypsin-like specificity with high selectivity for P1-Arg over Lys.	Lysine	79-82	kallikrein related peptidase 14	Homo sapiens	0-5
16862174-4	2007	A major acetylation site of Smad3 by p300/CBP is Lys-378 in the MH2 domain (Smad3C) known to be critical for the regulation of transcriptional activity.	Lysine	49-52	CREB binding protein	Homo sapiens	42-45
16862177-4	2007	In the present study, we report that for efficient ubiquitination of HIF-1alpha to occur, three conserved lysines are required in both the HIF-1alpha and endothelial Per-ARNT-Sim domain protein (EPAS) sequences.	Lysine	106-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
16862177-4	2007	In the present study, we report that for efficient ubiquitination of HIF-1alpha to occur, three conserved lysines are required in both the HIF-1alpha and endothelial Per-ARNT-Sim domain protein (EPAS) sequences.	Lysine	106-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
17438944-4	2007	METHODS: The model protein FITC-ovalbumin and EPO are protected by human serum albumin and poly-L-lysine complex and encapsulated in 50:50 poly(DL-lactide-co-glycolide) by a w/o/w solvent evaporation method.	Lysine	91-104	erythropoietin	Homo sapiens	46-49
17240993-1	2007	Tissue transglutaminase (TGase) is a Ca2+-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues and is allosterically regulated by GTP.	Lysine	190-193	transglutaminase 2	Homo sapiens	0-23
17098746-6	2007	This is consistent with recent studies showing that a lysine to arginine mutation at Lys-320 significantly enhances p53 function, although Lys-320 was originally identified as an acetylation site involving PCAF-mediated activation of p53.	Lysine	54-60	tumor protein p53	Homo sapiens	116-119
16979252-6	2007	Cytochemical studies with 4",6-diamidino-2-phenylindole (DAPI) staining of nuclei and immunofluorescence for secreted foreign human erythropoietin (hEPO) from recombinant S2 cells and quantitative comparative analyses of S2 cell binding ability with Cell-Tak and poly-L-lysine, the main cell adhesion agent, were performed to demonstrate successful usage of recombinant Mgfp-5 for cell biological applications.	Lysine	263-276	erythropoietin	Homo sapiens	148-152
17071614-7	2007	We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein.	Lysine	70-73	defensin beta 1	Homo sapiens	104-108
17071614-7	2007	We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein.	Lysine	79-82	defensin beta 1	Homo sapiens	104-108
17071614-7	2007	We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein.	Lysine	79-82	defensin beta 1	Homo sapiens	104-108
17079232-3	2007	Through a combination of proteomic screening and site-directed mutagenesis approaches, we have identified lysines 554, 779, and 804 as the major sumoylation sites in KAP1.	Lysine	106-113	tripartite motif containing 28	Homo sapiens	166-170
17098746-6	2007	This is consistent with recent studies showing that a lysine to arginine mutation at Lys-320 significantly enhances p53 function, although Lys-320 was originally identified as an acetylation site involving PCAF-mediated activation of p53.	Lysine	54-60	tumor protein p53	Homo sapiens	234-237
17098746-6	2007	This is consistent with recent studies showing that a lysine to arginine mutation at Lys-320 significantly enhances p53 function, although Lys-320 was originally identified as an acetylation site involving PCAF-mediated activation of p53.	Lysine	85-88	tumor protein p53	Homo sapiens	116-119
17098746-6	2007	This is consistent with recent studies showing that a lysine to arginine mutation at Lys-320 significantly enhances p53 function, although Lys-320 was originally identified as an acetylation site involving PCAF-mediated activation of p53.	Lysine	85-88	tumor protein p53	Homo sapiens	234-237
17102136-6	2007	Substitution of 4 closely spaced amino acid residues of the haptoglobin beta-chain (valine 259, glutamate 261, lysine 262, and threonine 264) abrogated the high affinity receptor binding.	Lysine	111-117	haptoglobin	Homo sapiens	60-71
17202337-6	2007	The lysine residue in the transmembrane region of MAIR-II was involved in the association with FcRgamma chain as well as DAP12.	Lysine	4-10	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	95-103
17257442-11	2007	CONCLUSION: We show that the majority of lysine-dependent plasminogen binding to breast cancer cells is ultimately regulated by plasmin activity and is dependent on the presence of significant levels of active uPA.	Lysine	41-47	plasminogen activator, urokinase	Homo sapiens	210-213
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	82-88	SMAD family member 7	Homo sapiens	118-123
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	99-102	SMAD family member 7	Homo sapiens	118-123
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 12	Homo sapiens	75-80
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 5	Homo sapiens	81-85
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 5	Homo sapiens	146-150
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 12	Homo sapiens	155-160
17114793-6	2007	Rab38(CAKS) is not methylated in vivo, presumably because of the inhibitory action of the lysine residue within the AAX motif for cleavage by Rce1.	Lysine	90-96	Ras converting CAAX endopeptidase 1	Homo sapiens	142-146
17197424-7	2007	A lysine residue in TALK-2 fulfills the same role but with a largely unchanged pKa, which correlates with an environment that stabilizes its positive charge.	Lysine	2-8	potassium two pore domain channel subfamily K member 17	Homo sapiens	20-26
17222361-4	2007	RESULTS: Among the 46 specimens of NPC, 2 (4.3%) had point mutation in PIK3CA exon 9 [T1563G (521Asn--&gt;Lys) and A1646G (549Asp--&gt;Gly)], 18 had multiple mutations in PIK3CA exon 9 (A1634C-G1658C-del 1659T), which might be the homologous sequence of Cat Eye Syndrome region on 22q11.2; none had mutation in PIK3CA exon 20.	Lysine	106-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	71-77
17634147-8	2007	The WT1-ZF form lacking the lysine-threonine-serine (KTS) insert (ZF - KTS) can bind to the majority of WT1 consensus sites throughout the WT1 promoter region, while the ZF containing the insert (ZF + KTS) form only binds to sites in the proximal promoter.	Lysine	28-34	WT1 transcription factor	Homo sapiens	4-7
17634147-8	2007	The WT1-ZF form lacking the lysine-threonine-serine (KTS) insert (ZF - KTS) can bind to the majority of WT1 consensus sites throughout the WT1 promoter region, while the ZF containing the insert (ZF + KTS) form only binds to sites in the proximal promoter.	Lysine	28-34	WT1 transcription factor	Homo sapiens	104-107
17634147-8	2007	The WT1-ZF form lacking the lysine-threonine-serine (KTS) insert (ZF - KTS) can bind to the majority of WT1 consensus sites throughout the WT1 promoter region, while the ZF containing the insert (ZF + KTS) form only binds to sites in the proximal promoter.	Lysine	28-34	WT1 transcription factor	Homo sapiens	104-107
17210717-6	2007	Interestingly, the levels of trimethylation of histone H3 on lysine 9, which usually marks inactive chromatin regions and was associated with the p16 promoter in silenced T24 cells, did not change after drug treatments.	Lysine	61-67	cyclin dependent kinase inhibitor 2A	Homo sapiens	146-149
17060459-5	2007	TDG is also posttranslationally modified by covalent conjugation of SUMO-1 (sumoylation) to lysine 341.	Lysine	92-98	thymine DNA glycosylase	Homo sapiens	0-3
18419267-3	2007	The Lys-14 residue of histone H3 is a preferential target of CLOCK-mediated acetylation.	Lysine	4-7	circadian locomotor output cycles kaput	Mus musculus	61-66
17284929-0	2007	Lys, pro and trp are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens.	Lysine	0-3	coagulation factor II, thrombin	Homo sapiens	106-121
17284929-14	2007	CONCLUSIONS: The lysine, proline and tryptophan residues located on the N-terminal region of fungal serine proteases are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens.	Lysine	17-23	coagulation factor II, thrombin	Homo sapiens	100-115
17962312-6	2007	The automethylation motif of G9a flanking target K239 (ARKT) has similarity with histone H3 lysine 9 regions (ARKS), and is identical to amino acids residues in EuHMT (ARKT) and mAM (ARKT).	Lysine	92-98	PZP, alpha-2-macroglobulin like	Mus musculus	178-181
17088385-1	2007	A comparative global proteomic screen identified factors required for COMPASS (complex of proteins associated with Set1)-mediated mono-, di-, and trimethylation of the fourth lysine of histone H3 (H3K4), which included components of a cyclin-dependent protein kinase (Ctk complex) that phosphorylates the C-terminal domain of the largest subunit of RNA polymerase II (Pol II).	Lysine	175-181	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	115-119
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Lysine	86-92	insulin	Homo sapiens	0-7
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Lysine	171-174	lysozyme	Homo sapiens	25-33
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Lysine	171-174	lysozyme	Homo sapiens	57-65
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Lysine	86-92	insulin	Homo sapiens	45-52
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Lysine	145-151	insulin	Homo sapiens	0-7
17703632-6	2007	Insulin glulisine (Apidra) is a rapid-acting insulin analogue created by substituting lysine for asparagine at position B3 and glutamic acid for lysine at position B29 on the B chain of human insulin.	Lysine	145-151	insulin	Homo sapiens	45-52
18458408-14	2006	The TGF-beta(1) gene transfected MSCs/poly-L-lysine coated PLA composite allografts used in this study are effective for articular cartilage repair.	Lysine	38-51	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	4-15
17034816-0	2006	A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L.	Lysine	8-14	G protein nucleolar 3 like	Homo sapiens	128-133
17034816-6	2006	We demonstrate here that GNL3L is transported into the nucleolus by a novel lysine-rich nucleolar localization signal (NoLS) residing within 1-50 amino acid residues.	Lysine	76-82	G protein nucleolar 3 like	Homo sapiens	25-30
17034816-8	2006	We show for the first time that the lysine-rich targeting signal interacts with the nuclear transport receptor, importin-beta and transports GNL3L into the nucleolus.	Lysine	36-42	G protein nucleolar 3 like	Homo sapiens	141-146
17148662-2	2006	Mutations in OPTN such as Glu50--&gt;Lys (E50K) have been reported in patients, particularly those with normal pressure glaucoma.	Lysine	37-40	optineurin	Homo sapiens	13-17
17097055-6	2006	Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer.	Lysine	39-45	small ubiquitin-like modifier 1	Mus musculus	9-15
17097055-6	2006	Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer.	Lysine	39-45	fibroblast growth factor 4	Mus musculus	105-109
17072594-1	2006	Fructosamine-3-kinase (FN3K) mediates the regeneration of lysine from fructosamines formed on proteins as a result of the "early" Maillard reaction.	Lysine	58-64	fructosamine 3 kinase	Homo sapiens	0-21
17072594-1	2006	Fructosamine-3-kinase (FN3K) mediates the regeneration of lysine from fructosamines formed on proteins as a result of the "early" Maillard reaction.	Lysine	58-64	fructosamine 3 kinase	Homo sapiens	23-27
17030603-7	2006	In dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected.	Lysine	53-60	transcriptional Adaptor 2a	Drosophila melanogaster	3-9
17049505-6	2006	l-Lysine up-regulated p53, p21, and Bax protein levels and a down-regulation of Bcl-2alpha in all the cell lines tested.	Lysine	0-8	tumor protein p53	Homo sapiens	22-25
17049505-6	2006	l-Lysine up-regulated p53, p21, and Bax protein levels and a down-regulation of Bcl-2alpha in all the cell lines tested.	Lysine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	36-39
17079264-3	2006	Previous work has shown that the upregulation of FLC in FRI- or AP-mutant backgrounds is correlated to an increase in histone H3 lysine 4 (H3K4) trimethylation at the FLC locus.	Lysine	129-135	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	49-52
17079264-3	2006	Previous work has shown that the upregulation of FLC in FRI- or AP-mutant backgrounds is correlated to an increase in histone H3 lysine 4 (H3K4) trimethylation at the FLC locus.	Lysine	129-135	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	167-170
17362353-1	2006	We have identified dEset, the fly homolog of human SETDB1 and mouse ESET histone lysine methyltransferases (HKMTases) that methylates the lysine 9 residue of histone 3 (H3-K9) and negatively regulates transcription of target genes.	Lysine	81-87	eggless	Drosophila melanogaster	19-24
17362353-1	2006	We have identified dEset, the fly homolog of human SETDB1 and mouse ESET histone lysine methyltransferases (HKMTases) that methylates the lysine 9 residue of histone 3 (H3-K9) and negatively regulates transcription of target genes.	Lysine	81-87	eggless	Drosophila melanogaster	68-72
17230638-4	2006	Neural precursor cells from the midkine-deficient brain spread poorly and grew less effectively on a substratum coated with poly-l-lysine than the cells on midkine-coated substratum.	Lysine	124-137	midkine	Homo sapiens	32-39
17105585-7	2006	Patients with DRB1*03-DRB1*04 who had 3-4 alleles encoding lysine at position DRbeta71 within the class II molecule of the major histocompatibility complex developed cirrhosis more commonly (75% vs 9%, P = 0.05) and had a higher frequency of hepatic-related death or liver transplantation (40% vs 0%, P = 0.04) than patients with fewer alleles.	Lysine	59-65	major histocompatibility complex, class II, DR beta 1	Homo sapiens	14-18
17105585-7	2006	Patients with DRB1*03-DRB1*04 who had 3-4 alleles encoding lysine at position DRbeta71 within the class II molecule of the major histocompatibility complex developed cirrhosis more commonly (75% vs 9%, P = 0.05) and had a higher frequency of hepatic-related death or liver transplantation (40% vs 0%, P = 0.04) than patients with fewer alleles.	Lysine	59-65	major histocompatibility complex, class II, DR beta 1	Homo sapiens	22-26
17030603-7	2006	In dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected.	Lysine	172-179	transcriptional Adaptor 2a	Drosophila melanogaster	3-9
17030603-7	2006	In dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected.	Lysine	172-179	transcriptional Adaptor 2b	Drosophila melanogaster	133-139
17030603-8	2006	The data presented here, together with our earlier data on the function of dAda2b, provide evidence that related Ada2 proteins of Drosophila, together with Gcn5 HAT, are involved in the acetylation of specific lysine residues in the N-terminal tails of nucleosomal H3 and H4.	Lysine	210-216	transcriptional Adaptor 2b	Drosophila melanogaster	75-81
17108971-2	2006	The tumour suppressor p53 (refs 4-7) is one of only a few non-histone proteins known to be regulated by lysine methylation.	Lysine	104-110	tumor protein p53	Homo sapiens	22-25
17172412-2	2006	The polycomb repressive complex 2 complex possesses histone methyltransferase activity mediated by the Su(var)3-9, enhancer of zeste, and trithorax domain of EZH2, which methylates histone H3 on lysine (K)-27 (H3K27).	Lysine	195-201	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	158-162
16767160-4	2006	The acetylation site was determined to be lysine-697, which is located adjacent to the C-terminal Cdc4 phospho-degron (CPD).	Lysine	42-48	F-box and WD-40 domain protein 7	Mus musculus	98-102
17108971-3	2006	Here we report a lysine methyltransferase, Smyd2, that methylates a previously unidentified site, Lys 370, in p53.	Lysine	98-101	tumor protein p53	Homo sapiens	110-113
17108971-4	2006	This methylation site, in contrast to the known site Lys 372, is repressing to p53-mediated transcriptional regulation.	Lysine	53-56	tumor protein p53	Homo sapiens	79-82
17108971-8	2006	In addition, we show that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and Smyd2.	Lysine	51-54	tumor protein p53	Homo sapiens	150-153
16916529-5	2006	Within this domain, highly conserved lysine and arginine residues significantly contributed to Nef"s membrane association and localization.	Lysine	37-43	S100 calcium binding protein B	Homo sapiens	95-98
16916529-7	2006	Importantly, two lysines at positions 4 and 7 were not essential for the overall membrane association but critically contributed to Nef"s incorporation into lipid raft domains.	Lysine	17-24	S100 calcium binding protein B	Homo sapiens	132-135
17108971-8	2006	In addition, we show that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and Smyd2.	Lysine	74-77	tumor protein p53	Homo sapiens	150-153
16916529-8	2006	Cell surface receptor downmodulation was largely unaffected by mutations of all N-terminal basic residues, while the association of Nef with Pak2 kinase activity and its ability to augment virion infectivity correlated with its lysine-mediated raft incorporation.	Lysine	228-234	S100 calcium binding protein B	Homo sapiens	132-135
17108971-9	2006	Thus, similar to histones, p53 is subject to both activating and repressing lysine methylation.	Lysine	76-82	tumor protein p53	Homo sapiens	27-30
16987819-9	2006	The complex formed by LSD1 with histone deacetylases 1/2 may function as a "double-blade razor" that first eliminates the acetyl groups from acetylated Lys residues and then removes the methyl group from Lys4.	Lysine	152-155	histone deacetylase 1	Homo sapiens	32-56
16919702-4	2006	It has now been demonstrated here that acetylation of a lysine, equivalent to position 261 in Ad12 E1A and position 285 in Ad5E1A, in a synthetic peptide disrupts the binding to CtBP1 and CtBP2 and alters the K(i) of the peptide, indicative of a reduction in the affinity of the peptide for CtBP1 and CtBP2, but only to a rather limited extent (less than 2-fold).	Lysine	56-62	C-terminal binding protein 2	Homo sapiens	188-193
16919702-4	2006	It has now been demonstrated here that acetylation of a lysine, equivalent to position 261 in Ad12 E1A and position 285 in Ad5E1A, in a synthetic peptide disrupts the binding to CtBP1 and CtBP2 and alters the K(i) of the peptide, indicative of a reduction in the affinity of the peptide for CtBP1 and CtBP2, but only to a rather limited extent (less than 2-fold).	Lysine	56-62	C-terminal binding protein 2	Homo sapiens	301-306
16987813-2	2006	TGase 2 catalyzes covalent isopeptide bond formation between the peptide bound-glutamine and the lysine residues.	Lysine	97-103	transglutaminase 2	Homo sapiens	0-7
17012228-9	2006	Site-directed mutagenesis studies showed that Lys-386 of p53, the SUMO-1 modification site, is also the modification site for SUMO-2/3.	Lysine	46-49	tumor protein p53	Homo sapiens	57-60
16921172-0	2006	Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation.	Lysine	92-98	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	32-36
16921172-1	2006	Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4).	Lysine	135-141	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	0-4
16921172-1	2006	Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4).	Lysine	135-141	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	88-92
16987813-4	2006	Although there appeared to be no requirement for specific lysine residues, we found a considerably higher preference for the use of lysine residues at positions 21, 22, and 177 in TGase 2-mediated cross-linking of I-kappaBalpha.	Lysine	132-138	transglutaminase 2	Homo sapiens	180-187
16987813-4	2006	Although there appeared to be no requirement for specific lysine residues, we found a considerably higher preference for the use of lysine residues at positions 21, 22, and 177 in TGase 2-mediated cross-linking of I-kappaBalpha.	Lysine	132-138	NFKB inhibitor alpha	Homo sapiens	214-227
17114581-5	2006	This response was correlated with the rate of accumulation of FLC histone H3 Lys 27 trimethylation (H3K27me3).	Lysine	77-80	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	62-65
16987813-6	2006	Furthermore, the depletion of free I-kappaBalpha in EcR/TG cells was completely rescued in vivo by transfection of mutant I-kappaBalphas in glutamine sites (Q266G, Q267G, and Q313G) as well as in a lysine site (K177G).	Lysine	198-204	NFKB inhibitor alpha	Homo sapiens	35-48
17110336-3	2006	E4F1 stimulates oligo-ubiquitylation in the hinge region of p53 on lysine residues distinct from those targeted by Hdm2 and previously described to be acetylated by the acetyltransferase PCAF.	Lysine	67-73	tumor protein p53	Homo sapiens	60-63
17066076-2	2006	MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters by methylation of lysine 9 of histone H3.	Lysine	151-157	methyl-CpG binding domain protein 1	Homo sapiens	0-4
17066076-2	2006	MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters by methylation of lysine 9 of histone H3.	Lysine	151-157	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	63-69
17066076-4	2006	Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1.	Lysine	177-183	methyl-CpG binding domain protein 1	Homo sapiens	18-22
17066076-4	2006	Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1.	Lysine	177-183	protein inhibitor of activated STAT 3	Homo sapiens	105-110
16873541-8	2006	Chronic treatment with leptin reduced thymic apoptosis, an effect that was not inhibited by the JAK inhibitor AG(490) but was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY(294002) and an antisense oligonucleotide to IRS-1.	Lysine	197-199	insulin receptor substrate 1	Rattus norvegicus	244-249
17085592-6	2006	Mechanistically, the dsRNA-induced gene activation requires the Argonaute 2 (Ago2) protein and is associated with a loss of lysine-9 methylation on histone 3 at dsRNA-target sites.	Lysine	124-130	argonaute RISC catalytic component 2	Homo sapiens	64-75
17085592-6	2006	Mechanistically, the dsRNA-induced gene activation requires the Argonaute 2 (Ago2) protein and is associated with a loss of lysine-9 methylation on histone 3 at dsRNA-target sites.	Lysine	124-130	argonaute RISC catalytic component 2	Homo sapiens	77-81
17063450-6	2006	Furthermore, each sugar moiety produced indicative lysine-derived immonium ions that were successfully used in a precursor ion scan analysis to identify Amadori peptides in a tryptic digest of bovine serum albumin (BSA) glycated with D-glucose.	Lysine	51-57	albumin	Homo sapiens	200-213
17028573-5	2006	Furthermore, AIP4-generated polyubiquitin chains are mainly conjugated through lysine 29 of ubiquitin in vivo, indicating a link between this type of chain and lysosomal degradation.	Lysine	79-85	itchy E3 ubiquitin protein ligase	Homo sapiens	13-17
17081058-0	2006	Mass spectrometry-based glycoproteomic approach involving lysine derivatization for structural characterization of recombinant human erythropoietin.	Lysine	58-64	erythropoietin	Homo sapiens	133-147
17081058-1	2006	Lysine-containing peptides comprising glycosylation sites derived from recombinant human erythropoietin (rHuEPO) by trypsin or Lys-C and PNGase F dual digestion were derivatized with 2-methoxy-4,5-dihydro-1H-imidazole and its deuterated analogues.	Lysine	0-6	erythropoietin	Homo sapiens	89-103
16887934-5	2006	In normoxia, hydroxylation of two proline residues and acetylation of a lysine residue at the oxygen-dependent degradation domain (ODDD) of HIF-1alpha trigger its association with pVHL E3 ligase complex, leading to HIF-1alpha degradation via ubiquitin-proteasome pathway.	Lysine	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-150
17313100-3	2006	The intra-molecular bridge is generated by the loss of an ammonia molecule between the unique Ione-pair donating nucleophile Lys-6 and one acceptor among the seven glutamine residues of statherin.	Lysine	125-128	statherin	Homo sapiens	186-195
16923962-4	2006	SIRT1 binds and deacetylates the AR at a conserved lysine motif.	Lysine	51-57	androgen receptor	Homo sapiens	33-35
16923962-5	2006	Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.	Lysine	127-133	androgen receptor	Homo sapiens	47-49
16887934-5	2006	In normoxia, hydroxylation of two proline residues and acetylation of a lysine residue at the oxygen-dependent degradation domain (ODDD) of HIF-1alpha trigger its association with pVHL E3 ligase complex, leading to HIF-1alpha degradation via ubiquitin-proteasome pathway.	Lysine	72-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	215-225
16923962-5	2006	Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.	Lysine	127-133	androgen receptor	Homo sapiens	124-126
16899318-3	2006	In this study, we examined the feasibility of FITC-labeled poly-L-lysine-CF3 (PLK-CF3) using glial cells.	Lysine	59-72	coagulation factor III	Mus musculus	73-76
16923967-0	2006	The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.	Lysine	86-92	Yng1p	Saccharomyces cerevisiae S288C	4-9
16923967-6	2006	Using the toxicity of YNG1 overexpression as a tool, we showed that Yng1p interacts with the amino-terminal tail of histone H3 and that this interaction can be disrupted by loss of lysine 4 methylation within this tail.	Lysine	181-187	Yng1p	Saccharomyces cerevisiae S288C	68-73
16923967-7	2006	Additionally, we mapped the region of Yng1p required for overexpression of toxicity to the PHD finger, showed that this region capable of binding lysine 4-methylated histone H3 in vitro, and demonstrated that mutations of the PHD finger that abolish binding in vitro are no longer toxic in vivo.	Lysine	146-152	Yng1p	Saccharomyces cerevisiae S288C	38-43
16923967-8	2006	These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation.	Lysine	159-165	Yng1p	Saccharomyces cerevisiae S288C	48-53
17075129-1	2006	Understanding substrate specificity and identification of natural targets of transglutaminase 2 (TG2), the ubiquitous multifunctional cross-linking enzyme, which forms isopeptide bonds between protein-linked glutamine and lysine residues, is crucial in the elucidation of its physiological role.	Lysine	222-228	transglutaminase 2	Homo sapiens	77-95
17075129-1	2006	Understanding substrate specificity and identification of natural targets of transglutaminase 2 (TG2), the ubiquitous multifunctional cross-linking enzyme, which forms isopeptide bonds between protein-linked glutamine and lysine residues, is crucial in the elucidation of its physiological role.	Lysine	222-228	transglutaminase 2	Homo sapiens	97-100
17034130-9	2006	Negative charge density in the neighborhood of position 88 (a Lys insertion in thrombin) is found to be a determinant for thrombin recognition.	Lysine	62-65	coagulation factor II, thrombin	Homo sapiens	79-87
17034130-9	2006	Negative charge density in the neighborhood of position 88 (a Lys insertion in thrombin) is found to be a determinant for thrombin recognition.	Lysine	62-65	coagulation factor II, thrombin	Homo sapiens	122-130
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Lysine	318-321	metallothionein 1A	Homo sapiens	59-63
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Lysine	318-321	metallothionein 1A	Homo sapiens	193-197
16936141-7	2006	As a consequence, growth of the gto1 mutant is delayed in growth medium without lysine, serine, or threonine, and the mutant cells have low levels of reduced glutathione.	Lysine	80-86	omega-class glutathione transferase	Saccharomyces cerevisiae S288C	32-36
16857189-0	2006	The N-terminal lysine residue-rich domain II and the 340-430 amino acid segment of eukaryotic initiation factor 2-associated glycoprotein p67 are the binding sites for the gamma-subunit of eIF2.	Lysine	15-21	eukaryotic translation initiation factor 2 subunit gamma	Homo sapiens	189-193
16857189-5	2006	Further mutational analyses provided evidence that the N-terminal lysine-rich domain II and the 340-430 amino acid segment of p67 interact strongly with the C-terminal 409-472 amino acid segment of eIF2gamma.	Lysine	66-72	CD33 molecule	Homo sapiens	126-129
16857189-5	2006	Further mutational analyses provided evidence that the N-terminal lysine-rich domain II and the 340-430 amino acid segment of p67 interact strongly with the C-terminal 409-472 amino acid segment of eIF2gamma.	Lysine	66-72	eukaryotic translation initiation factor 2 subunit gamma	Homo sapiens	198-207
17032155-2	2006	We coupled anti-PSMA monoclonal antibody with poly-L-lysine and then incubated it with plasmids.	Lysine	46-59	folate hydrolase 1	Homo sapiens	16-20
17024155-6	2006	In this capacity menin is a regulator of expression of the cyclin-dependent-kinase inhibitors p18INK4C and p27Kip1; furthermore, menin serves as a co-activator of estrogen receptor mediated transcription, by recruiting methyltransferase activity to lysine 4 of histone 3 at the estrogen responsive TFF1(pS2) gene promoter.	Lysine	249-255	menin 1	Homo sapiens	17-22
17024155-6	2006	In this capacity menin is a regulator of expression of the cyclin-dependent-kinase inhibitors p18INK4C and p27Kip1; furthermore, menin serves as a co-activator of estrogen receptor mediated transcription, by recruiting methyltransferase activity to lysine 4 of histone 3 at the estrogen responsive TFF1(pS2) gene promoter.	Lysine	249-255	cyclin dependent kinase inhibitor 2C	Homo sapiens	94-102
17024155-6	2006	In this capacity menin is a regulator of expression of the cyclin-dependent-kinase inhibitors p18INK4C and p27Kip1; furthermore, menin serves as a co-activator of estrogen receptor mediated transcription, by recruiting methyltransferase activity to lysine 4 of histone 3 at the estrogen responsive TFF1(pS2) gene promoter.	Lysine	249-255	menin 1	Homo sapiens	129-134
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Lysine	212-218	coagulation factor II, thrombin	Homo sapiens	58-66
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Lysine	212-218	coagulation factor II, thrombin	Homo sapiens	154-162
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Lysine	220-223	coagulation factor II, thrombin	Homo sapiens	58-66
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Lysine	220-223	coagulation factor II, thrombin	Homo sapiens	154-162
16916794-3	2006	Substitution of specific lysine residues in Dpb3p, highlighted by homology modeling of Dpb3p-Dpb4p based on the structure of the histone H2A-H2B dimer, indicated that they play roles in binding of dsDNA by Dpb3p-Dpb4p, in a manner similar to the histone-DNA interaction.	Lysine	25-31	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	93-98
16916794-3	2006	Substitution of specific lysine residues in Dpb3p, highlighted by homology modeling of Dpb3p-Dpb4p based on the structure of the histone H2A-H2B dimer, indicated that they play roles in binding of dsDNA by Dpb3p-Dpb4p, in a manner similar to the histone-DNA interaction.	Lysine	25-31	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	212-217
16916794-5	2006	Furthermore, additional amino acid substitutions to lysines in Dpb4p, to compensate for the loss of positive charges in the Dpb3p mutants, resulted in simultaneous restoration of dsDNA-binding activity by Pol epsilon and telomeric silencing.	Lysine	52-59	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	63-68
16926151-6	2006	Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity as measured by an increased acetylation of RelA/p65 at Lys(310), a modification that is required for full NF-kappaB transcription.	Lysine	146-149	AKT serine/threonine kinase 1	Homo sapiens	0-3
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	AKT serine/threonine kinase 1	Homo sapiens	38-41
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	BCL2 related protein A1	Homo sapiens	287-292
17054391-13	2006	Furthermore, we find that CBP has a significantly higher probability of being close to its known in vivo substrate histone H4 lysine 5 compared with the closely related H4 lysine 12.	Lysine	126-132	CREB binding protein	Homo sapiens	26-29
17054391-13	2006	Furthermore, we find that CBP has a significantly higher probability of being close to its known in vivo substrate histone H4 lysine 5 compared with the closely related H4 lysine 12.	Lysine	172-178	CREB binding protein	Homo sapiens	26-29
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Lysine	35-38	peroxisome proliferator activated receptor gamma	Homo sapiens	218-266
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Lysine	35-38	peroxisome proliferator activated receptor gamma	Homo sapiens	268-277
16899318-3	2006	In this study, we examined the feasibility of FITC-labeled poly-L-lysine-CF3 (PLK-CF3) using glial cells.	Lysine	59-72	coagulation factor III	Mus musculus	82-85
16951351-4	2006	Surprisingly, the Lys at the P2 position appears to play a dual role by participating in peptide binding via interactions with DRB1-His81 and Asn82, and TCR interaction, based on functional assays.	Lysine	18-21	major histocompatibility complex, class II, DR beta 1	Homo sapiens	127-131
16920285-9	2006	Among the 17 glycation sites, only lysine 525 of human serum albumin has been found in vivo in diabetic patients by Shaklai et al.	Lysine	35-41	albumin	Homo sapiens	55-68
16809339-7	2006	EPR and structural data suggest that membrane interaction of COX-2 is also aided by partitioning of 4 aromatic amino acids, Phe(59), Phe(66), Tyr(76), and Phe(84) to the interfacial region, and by the electrostatic interactions of two basic amino acids, Arg(62) and Lys(64), with the phospholipid head groups.	Lysine	266-269	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
16946699-4	2006	The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4.	Lysine	236-242	WD repeat domain 5	Homo sapiens	27-31
16946699-4	2006	The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4.	Lysine	236-242	WD repeat domain 5	Homo sapiens	137-141
16953564-2	2006	Three regions in TIM exhibit conformational transitions on the micros-ms time scale as detected by chemical exchange broadening effects in NMR spectroscopy: residue Lys 84 on helix C, located at the dimeric interface; active site loop 6; and helix G. The results indicate that the conformational exchange process affecting the residues of loop 6 is the correlated opening and closing of the loop.	Lysine	165-168	triosephosphate isomerase 1	Homo sapiens	17-20
16936264-5	2006	The generation of the anti-apoptotic signal on binding of TNF-alpha to the TNF receptor (TNFR)1 has been shown to be associated with the recruitment of TRAF2 to the TNFR1 in a process that requires ubiquitination of TRAF2 with lysine-63-linked polyubiquitin chains.	Lysine	227-233	tumor necrosis factor	Homo sapiens	58-67
16829529-7	2006	AtGRXcp expression can also suppress iron accumulation and partially rescue the lysine auxotrophy of yeast grx5 cells.	Lysine	80-86	monothiol glutaredoxin GRX5	Saccharomyces cerevisiae S288C	107-111
16946709-4	2006	We also demonstrate that acetylation of lysine 320 (K320) of p53 is specifically involved in the promotion of neurite outgrowth and in the regulation of the expression of Coronin 1b and Rab13.	Lysine	40-46	RAB13, member RAS oncogene family	Mus musculus	186-191
16906149-9	2006	Activity of STIM1 requires an ERM domain, which mediates the selective binding of STIM1 to TRPC1, 2 and 4, but not to TRPC3, 6 or 7, and a cationic lysine-rich region, which is essential for gating of TRPC1.	Lysine	148-154	stromal interaction molecule 1	Homo sapiens	12-17
17055289-5	2006	In TNF proteins, the cationic groups Lys preferred to be in helix while Arg preferred to be in strand regions while in Interleukins the Arg residues preferred to be in helix and Lys preferred to be in strand regions.	Lysine	37-40	tumor necrosis factor	Homo sapiens	3-6
17055289-5	2006	In TNF proteins, the cationic groups Lys preferred to be in helix while Arg preferred to be in strand regions while in Interleukins the Arg residues preferred to be in helix and Lys preferred to be in strand regions.	Lysine	178-181	tumor necrosis factor	Homo sapiens	3-6
16918599-10	2006	Similar to the primary tumour, the cell line showed p53 overexpression and had p53 mutation at codon 132: AAG (lys)--&gt;AAT (asp).	Lysine	111-114	tumor protein p53	Homo sapiens	79-82
16862162-1	2006	The Ubc13 E2 ubiquitin-conjugating enzyme is key in the process of "tagging" target proteins with lysine 63-linked polyubiquitin chains, which are essential for the transmission of immune receptor signals culminating in activation of the transcription factor NF-kappaB.	Lysine	98-104	nuclear factor kappa B subunit 1	Homo sapiens	259-268
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Lysine	13-19	Cbf2p	Saccharomyces cerevisiae S288C	76-81
16790436-4	2006	Both motifs recognize overlapping surfaces on Keap1, and the seven lysine residues of Nrf2 that act as ubiquitin acceptors lie between them.	Lysine	67-73	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
16790436-6	2006	This two-site interaction between Keap1 and Nrf2 constrains the mobility of the target lysine residues in the Neh2 domain, increasing their average concentration in the vicinity of the Rbx-bound ubiquitin-conjugating enzyme, and thus the rate at which the transcription factor is ubiquitylated.	Lysine	87-93	kelch like ECH associated protein 1	Homo sapiens	34-39
16790436-6	2006	This two-site interaction between Keap1 and Nrf2 constrains the mobility of the target lysine residues in the Neh2 domain, increasing their average concentration in the vicinity of the Rbx-bound ubiquitin-conjugating enzyme, and thus the rate at which the transcription factor is ubiquitylated.	Lysine	87-93	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
16828461-8	2006	These findings imply that SUMO-1 modification on lysine 75 may participate in regulating SOD1 stability and its aggregation process.	Lysine	49-55	superoxide dismutase 1	Homo sapiens	89-93
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Lysine	13-19	Cbf2p	Saccharomyces cerevisiae S288C	131-136
16882721-1	2006	The Rtf1 subunit of the Paf1 complex is required for proper monoubiquitination of histone H2B and methylation of histone H3 on lysines 4 (H3K4) and 79 in yeast Saccharomyces cerevisiae.	Lysine	127-134	Paf1p	Saccharomyces cerevisiae S288C	24-28
16757475-3	2006	Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the presence of MCAF1.	Lysine	182-188	methyl-CpG binding domain protein 1	Homo sapiens	132-136
16757475-3	2006	Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the presence of MCAF1.	Lysine	182-188	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	140-146
16912182-6	2006	More interestingly, the expression level of acetyltransferase cyclic AMP-responsive element binding protein-binding protein (CBP) is also increased in the Etk transgenic prostate as well as in a prostate cancer cell line overexpressing Etk, concomitant with elevated histone 3 acetylation at lysine 18 (H3K18Ac).	Lysine	292-298	CREB binding protein	Homo sapiens	125-128
16569758-2	2006	Control fetuses responded to both leucine and lysine infusions with increased arterial plasma insulin concentrations (average increase: 0.13 +/- 0.05 ng/ml leucine; 0.99 +/- 0.26 ng/ml lysine).	Lysine	46-52	insulin	Homo sapiens	94-101
16735510-4	2006	Multiple lysine residues, located within the tyrosine kinase domain of EGFR, serve as attachment sites for Nedd8.	Lysine	9-15	epidermal growth factor receptor	Homo sapiens	71-75
16737969-8	2006	In ZO1-PDZ1, an Asp residue makes favorable interactions with both Tyr(-1) and Lys/Arg(-3).	Lysine	79-82	tight junction protein 1	Homo sapiens	3-11
16737969-9	2006	In contrast, Erbin-PDZ contains an Arg at the equivalent position, and this side chain cannot accommodate either Tyr(-1) or Lys/Arg(-3) but, instead, interacts favorably with Glu/Asp(-3).	Lysine	124-127	erbb2 interacting protein	Homo sapiens	13-22
16569758-3	2006	In vivo lysine-stimulated insulin secretion was decreased by chronic (0.37 +/- 0.18 ng/ml) and acute (0.27 +/- 0.19 ng/ml) hypoglycemia.	Lysine	8-14	insulin	Homo sapiens	26-33
16569758-5	2006	Isolated pancreatic islets from chronically hypoglycemic fetuses had normal insulin and DNA content but decreased fractional insulin release when stimulated with glucose, leucine, arginine, or lysine.	Lysine	193-199	insulin	Homo sapiens	125-132
16750914-7	2006	MS/MS experiments revealed two lysine residues in the central alpha-helix of calmodulin as well as three lysine residues both in the C-terminal and N-terminal lobes of calmodulin to be cross-linked with one single lysine residue of the adenylyl cyclase 8 peptide.	Lysine	105-111	calmodulin 1	Homo sapiens	168-178
16861923-9	2006	Using a set of p63 deletion mutants, we have identified a region and two critical lysine residues of p63, associated to human Split-Hand and Foot Malformation-4 (SHFM-4) syndrome, which are involved in the mechanism of Itch-mediated p63 degradation.	Lysine	82-88	itchy E3 ubiquitin protein ligase	Homo sapiens	219-223
16866357-10	2006	Possible consequences of Tyr-97 phosphorylation with respect to cardiolipin binding and of location of Tyr-97 in close proximity to Lys-7, a crucial residue for interaction with Apaf-1 during apoptosis, are discussed.	Lysine	132-135	apoptotic peptidase activating factor 1	Homo sapiens	178-184
16783012-4	2006	This substitution appears to abolish all DNA damage-tolerance activities normally carried out by the RAD6/RAD18 pathway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-dependent component of this pathway, but has little effect on the growth rate, suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA.	Lysine	372-378	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	106-111
16750914-7	2006	MS/MS experiments revealed two lysine residues in the central alpha-helix of calmodulin as well as three lysine residues both in the C-terminal and N-terminal lobes of calmodulin to be cross-linked with one single lysine residue of the adenylyl cyclase 8 peptide.	Lysine	31-37	calmodulin 1	Homo sapiens	77-87
16750914-7	2006	MS/MS experiments revealed two lysine residues in the central alpha-helix of calmodulin as well as three lysine residues both in the C-terminal and N-terminal lobes of calmodulin to be cross-linked with one single lysine residue of the adenylyl cyclase 8 peptide.	Lysine	105-111	calmodulin 1	Homo sapiens	168-178
16702602-4	2006	ABCG1 and ABCG1-K120M, a WalkerA lysine mutant, were localized to the plasma membrane in HEK293 cells stably expressing ABCG1 and formed a homodimer.	Lysine	33-39	ATP binding cassette subfamily G member 1	Homo sapiens	10-15
16702602-4	2006	ABCG1 and ABCG1-K120M, a WalkerA lysine mutant, were localized to the plasma membrane in HEK293 cells stably expressing ABCG1 and formed a homodimer.	Lysine	33-39	ATP binding cassette subfamily G member 1	Homo sapiens	10-15
16675661-5	2006	Substituting each of the four negatively charged glutamate residues that form the ion selectivity filter with neutral glutamine or positively charged lysine residues results in mutant channels whose DHP binding affinities are decreased up to 10-fold and are up to 150-fold less sensitive to Ca(2+) than wild-type channels.	Lysine	150-156	dihydropyrimidinase	Homo sapiens	199-202
16717091-2	2006	Endogenous EZH2, a polycomb group enzyme that methylates lysine 27 on histone H3, co-immunoprecipitates with CLOCK and BMAL1 throughout the circadian cycle in liver nuclear extracts.	Lysine	57-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	11-15
16891020-5	2006	Antisurvival and antiproliferative effects of EGFR-tk inhibition plus/minus irradiation were counteracted by adhesion to Fn relative to the control substratum, poly-L-lysine.	Lysine	160-173	epidermal growth factor receptor	Homo sapiens	46-50
16732292-3	2006	Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain.	Lysine	0-6	malic enzyme 2	Homo sapiens	82-85
16737973-7	2006	Further analysis of various RyR1 mutants containing successively smaller numbers of these mutations identified 2 amino acid residues (Gln(4020) and Lys(4021)) that, when mutated to their RyR3 counterparts (Leu(3873) and Gln(3874)), abolished 4-CmC activation of RyR1.	Lysine	148-151	ryanodine receptor 1	Homo sapiens	28-32
16737973-11	2006	Secondary structure modeling in the vicinity of the Gln(4020)-Lys(4021) dipeptide suggests that the region contains a surface-exposed region adjacent to a hydrophobic segment, indicating that both hydrophilic and hydrophobic regions of RyR1 are necessary for 4-CmC binding to the channel and/or to translate allosteric 4-CmC binding into channel activation.	Lysine	62-65	ryanodine receptor 1	Homo sapiens	236-240
16679316-5	2006	Subsequent tandem mass spectrometric (MS/MS) analysis of the selected cross-linked peptide candidates led to the identification of two intermolecular cross-links, Lys(428)(CYP2E1)-Asp(53)(b(5)) and Lys(434)(CYP2E1)-Glu(56)(b(5)), which provides the first direct experimental evidence for the interacting orientations of a microsomal P450 and its redox partner.	Lysine	163-166	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	172-178
16679316-5	2006	Subsequent tandem mass spectrometric (MS/MS) analysis of the selected cross-linked peptide candidates led to the identification of two intermolecular cross-links, Lys(428)(CYP2E1)-Asp(53)(b(5)) and Lys(434)(CYP2E1)-Glu(56)(b(5)), which provides the first direct experimental evidence for the interacting orientations of a microsomal P450 and its redox partner.	Lysine	163-166	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	207-213
16679316-5	2006	Subsequent tandem mass spectrometric (MS/MS) analysis of the selected cross-linked peptide candidates led to the identification of two intermolecular cross-links, Lys(428)(CYP2E1)-Asp(53)(b(5)) and Lys(434)(CYP2E1)-Glu(56)(b(5)), which provides the first direct experimental evidence for the interacting orientations of a microsomal P450 and its redox partner.	Lysine	198-201	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	172-178
16728394-7	2006	A striking feature is the replacement of a conserved Glu in PKA by Gln (Epac1) or Lys (Epac2).	Lysine	82-85	Rap guanine nucleotide exchange factor 4	Homo sapiens	87-92
16858404-1	2006	Suv39h1 is a histone H3 lysine-9 (H3-K9) specific methyltransferase (HMT) that is associated with gene silencing through chromatin modification.	Lysine	24-30	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
16732292-6	2006	So far, all characterized histone demethylases show enzymatic activity towards lysine residues modified in the me1 or me2 state, leaving open the possibility that me3 constitutes an irreversible modification.	Lysine	79-85	malic enzyme 2	Homo sapiens	118-121
16732293-2	2006	Tri- and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is required for the binding of the repressive protein HP1 and is associated with heterochromatin formation and transcriptional repression in a variety of species.	Lysine	26-32	malic enzyme 2	Homo sapiens	50-61
16579792-6	2006	The p53(F270A:6KR) chimaeric mutant (where 6KR refers to the simultaneous mutation of lysine residues at positions 370, 372, 373, 381, 382 and 386 to arginine) maintains the high-molecular-mass covalent adducts and is modified in an MDM2-dependent manner.	Lysine	86-92	tumor protein p53	Homo sapiens	4-7
16497729-0	2006	Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor.	Lysine	50-57	estrogen receptor 1	Homo sapiens	15-38
16819929-8	2006	The activity of the synthetic histatin 5 in which all of the Lys and Arg were substituted by Ala was at the same level as histatin 5.	Lysine	61-64	histatin 3	Homo sapiens	30-40
16788062-3	2006	The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo.	Lysine	71-74	sirtuin 3	Homo sapiens	26-31
16790548-12	2006	Lys-635 of mouse AceCS2 was identified as the targeted residue.	Lysine	0-3	acyl-CoA synthetase short-chain family member 1	Mus musculus	17-23
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	interleukin 6	Mus musculus	190-193
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	tumor necrosis factor	Mus musculus	250-254
16785530-7	2006	Indeed, forced expression of c-MIR in several B cell lines down-regulated the surface expression of MHC II, and down-regulation was found to depend on the presence of a single lysine residue in the cytoplasmic tail of the I-A beta-chain.	Lysine	176-182	histocompatibility 2, class II antigen A, beta 1	Mus musculus	222-230
16785530-8	2006	In a reconstitution system using 293T cells, we found that the lysine residue at position 225 in the I-A beta-chain was ubiquitinated by c-MIR.	Lysine	63-69	amyloid beta precursor protein	Homo sapiens	103-109
16705060-6	2006	TNF-alpha treatment decreased ATGL transcript in a time-dependent manner that paralleled TNF-alpha downregulation of PPARgamma with a maximal decrease noted by 6 h. TNF-alpha effects on ATGL were attenuated by pretreatment with PD-98059, LY-294002, or rapamycin, suggesting involvement of the p44/42 MAP kinase, PI 3-kinase, and p70 ribosomal protein S6 kinase signals.	Lysine	238-240	tumor necrosis factor	Mus musculus	0-9
16551273-0	2006	Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis.	Lysine	47-53	ATP binding cassette subfamily B member 1	Homo sapiens	155-159
16497729-2	2006	Using mutagenesis and mass spectrometry, we identified two conserved lysine residues in ERalpha (Lys266 and Lys268) that are the primary targets of p300-mediated acetylation.	Lysine	69-75	estrogen receptor 1	Homo sapiens	88-95
16497729-5	2006	Acetylation at Lys266 and Lys268, or substitution of the same residues with glutamine (i.e. K266/268Q), a residue that mimics acetylated lysine, enhances the DNA binding activity of ERalpha in EMSAs.	Lysine	137-143	estrogen receptor 1	Homo sapiens	182-189
16497731-0	2006	Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications.	Lysine	54-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
16636049-1	2006	Mammalian transglutaminase (TGase) catalyzes covalent cross-linking of peptide-bound lysine residues or incorporation of primary amines to limited glutamine residues in substrate proteins.	Lysine	85-91	coagulation factor XIII A chain	Homo sapiens	10-26
16636049-1	2006	Mammalian transglutaminase (TGase) catalyzes covalent cross-linking of peptide-bound lysine residues or incorporation of primary amines to limited glutamine residues in substrate proteins.	Lysine	85-91	coagulation factor XIII A chain	Homo sapiens	28-33
16751394-0	2006	The double lysine motif of tapasin is a retrieval signal for retention of unstable MHC class I molecules in the endoplasmic reticulum.	Lysine	11-17	TAP binding protein	Homo sapiens	27-34
16814719-4	2006	Here we show that physiological levels of nucleotides inhibit the CC-initiated apoptosome formation and caspase-9 activation by directly binding to CC on several key lysine residues and thus preventing CC interaction with Apaf-1.	Lysine	166-172	cytochrome c, somatic	Homo sapiens	66-68
16814719-4	2006	Here we show that physiological levels of nucleotides inhibit the CC-initiated apoptosome formation and caspase-9 activation by directly binding to CC on several key lysine residues and thus preventing CC interaction with Apaf-1.	Lysine	166-172	cytochrome c, somatic	Homo sapiens	148-150
16814719-4	2006	Here we show that physiological levels of nucleotides inhibit the CC-initiated apoptosome formation and caspase-9 activation by directly binding to CC on several key lysine residues and thus preventing CC interaction with Apaf-1.	Lysine	166-172	cytochrome c, somatic	Homo sapiens	148-150
16678126-5	2006	We have previously shown that signal-induced degradation of p105 requires ubiquitination on multiple lysines.	Lysine	101-108	nuclear factor kappa B subunit 1	Homo sapiens	60-64
16621799-0	2006	Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex.	Lysine	55-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	104-115
16621799-3	2006	We have shown previously that several conserved lysine residues (positions 68, 71, 80, and 104) within the collagenous domain of adiponectin are modified by hydroxylation and glycosylation (Wang, Y., Xu, A., Knight, C., Xu, L. Y., and Cooper, G. J.	Lysine	48-54	adiponectin, C1Q and collagen domain containing	Homo sapiens	129-140
16621799-14	2006	Taken together, these data suggest that hydroxylation and glycosylation of the lysine residues within the collagenous domain of adiponectin are critically involved in regulating the formation of its HMW oligomeric complex and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes.	Lysine	79-85	adiponectin, C1Q and collagen domain containing	Homo sapiens	128-139
16621799-14	2006	Taken together, these data suggest that hydroxylation and glycosylation of the lysine residues within the collagenous domain of adiponectin are critically involved in regulating the formation of its HMW oligomeric complex and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes.	Lysine	79-85	insulin	Homo sapiens	257-264
16621799-14	2006	Taken together, these data suggest that hydroxylation and glycosylation of the lysine residues within the collagenous domain of adiponectin are critically involved in regulating the formation of its HMW oligomeric complex and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes.	Lysine	79-85	adiponectin, C1Q and collagen domain containing	Homo sapiens	289-300
16751394-1	2006	Tapasin (tpn), an essential component of the MHC class I (MHC I) loading complex, has a canonical double lysine motif acting as a retrieval signal, which mediates retrograde transport of escaped endoplasmic reticulum (ER) proteins from the Golgi back to the ER.	Lysine	105-111	TAP binding protein	Homo sapiens	0-7
16774039-7	2006	Analysis of mutated forms of apoA-I has implicated lysine residues in the regiospecific chlorination of tyrosine.	Lysine	51-57	apolipoprotein A1	Homo sapiens	29-35
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	aryl hydrocarbon receptor nuclear translocator like 2	Homo sapiens	139-144
16840830-8	2006	The Turkish patient and her affected relatives all had a heterozygous A to G transition at codon 557 (AAG--&gt;GAG) of exon 10 of MEN1 that results in a replacement of lysine by glutamic acid.	Lysine	168-174	menin 1	Homo sapiens	130-134
16556651-10	2006	Further, individually mutating each of the hydrophilic residues on the S5P alpha-helix of hERG to a charged residue had significant effects on the voltage dependence of inactivation and the two residues with the greatest affect when mutated to a lysine, N588 and Q592, both lie on the same face of the S5P alpha -helix.	Lysine	246-252	ETS transcription factor ERG	Homo sapiens	90-94
16629671-5	2006	Disruption of SET1 resulted in complete loss of methylation of histone 3 at lysine residue 4, hyperfilamentous growth under embedded conditions, less negative cell surface charges and diminished adherence to epithelial cells, effects that were reversed upon gene re-insertion at a disrupted locus.	Lysine	76-82	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	14-18
16731913-0	2006	Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.	Lysine	29-35	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	41-45
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Lysine	66-69	toll-like receptor 4	Mus musculus	149-152
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Lysine	66-69	toll-like receptor 4	Mus musculus	157-161
16671751-3	2006	In an earlier work we have measured the proximity of the lysine (K6) side chain in an SN-15 peptide fragment of the salivary protein statherin adsorbed to the Phosphorus-rich surface of HAP using solid-state NMR recoupling experiments.	Lysine	57-63	statherin	Homo sapiens	133-142
17127468-4	2006	Effect of the protein hydrolysates on the CaM structure was greater with the fraction that contained higher contents of arginine and lysine when compared with the fraction with lower levels of these two amino acids.	Lysine	133-139	calmodulin 1	Homo sapiens	42-45
16611979-0	2006	Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo.	Lysine	108-114	SAGA histone acetyltransferase complex subunit SGF11	Saccharomyces cerevisiae S288C	75-81
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	76-79	GATA zinc finger domain containing 2A	Homo sapiens	5-13
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	87-90	GATA zinc finger domain containing 2A	Homo sapiens	5-13
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	87-90	GATA zinc finger domain containing 2A	Homo sapiens	5-13
16713561-2	2006	The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation.	Lysine	52-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-117
16520378-8	2006	The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM.	Lysine	82-85	STAM binding protein	Homo sapiens	118-122
16513638-5	2006	Ubiquitination of CaR was observed in the presence of the proteasomal inhibitor MG132; mutation of all putative intracellular loop and carboxyl-terminal lysine residues abolished ubiquitination of CaR.	Lysine	153-159	calcium sensing receptor	Homo sapiens	197-200
16464585-3	2006	Structure-activity relationship study indicated that C3 side chain of Orn as compared to C4 side chain of Lys at P1" position was better suited to inhibit ACE, with propionic acid (C3) derived heterocyclics and unnatural amino acids.	Lysine	106-109	angiotensin I converting enzyme	Homo sapiens	155-158
16603398-2	2006	Here, we present evidence that TNFalpha induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is required for the activation of IkappaB kinase (IKK) and NF-kappaB.	Lysine	82-85	tumor necrosis factor	Homo sapiens	31-39
16604209-3	2006	The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 via a 6-aminohexanoic acid residue as a spacer.	Lysine	23-29	CD40 ligand	Homo sapiens	75-80
16584196-1	2006	The kinetics and thermodynamics of the alkaline and acid conformational transitions of a Lys 79 --&gt; Ala/Asn 52 --&gt; Gly (A79G52) variant of iso-1-cytochrome c are studied.	Lysine	89-92	cytochrome c, somatic	Homo sapiens	151-163
16459334-5	2006	By performing alanine-scanning mutagenesis we identified a dilysine sequence (Lys(212)-Lys(216)) proximal to the transmembrane domain (TMD) that is important for both alpha-chain cell-surface expression and intracellular stability.	Lysine	78-81	Fc gamma receptor and transporter	Homo sapiens	167-178
16459334-5	2006	By performing alanine-scanning mutagenesis we identified a dilysine sequence (Lys(212)-Lys(216)) proximal to the transmembrane domain (TMD) that is important for both alpha-chain cell-surface expression and intracellular stability.	Lysine	87-90	Fc gamma receptor and transporter	Homo sapiens	167-178
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Lysine	32-35	Fc gamma receptor and transporter	Homo sapiens	122-133
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Lysine	32-35	Fc gamma receptor and transporter	Homo sapiens	302-313
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Lysine	41-44	Fc gamma receptor and transporter	Homo sapiens	122-133
16459334-6	2006	Furthermore, co-mutation of the Lys(212)-Lys(216) residues with the -3/-7 dilysine signal produced a dramatic increase in alpha-chain surface expression that was further increased by co-mutation of the lone charged residue (Asp(192)) in the TMD thereby defining three regions that function to regulate alpha-chain transport and in a highly synergistic manner.	Lysine	41-44	Fc gamma receptor and transporter	Homo sapiens	302-313
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Lysine	9-12	cytochrome c, somatic	Homo sapiens	118-130
16584196-12	2006	Both the Lys 79 --&gt; Ala and Asn 52 --&gt; Gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c.	Lysine	9-12	cytochrome c, somatic	Homo sapiens	212-224
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Lysine	52-58	cytochrome c, somatic	Homo sapiens	242-254
16600877-0	2006	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.	Lysine	71-77	WD repeat domain 5	Homo sapiens	101-105
16497665-5	2006	Using site-directed mutagenesis, we now demonstrate that lysine residues direct tyrosine chlorination in apoA-I.	Lysine	57-63	apolipoprotein A1	Homo sapiens	105-111
16671360-6	2006	Although mouse p19Arf contains only a single lysine residue and human p14ARF has none, both proteins are N-terminally ubiquitinated and degraded in proteasomes.	Lysine	45-51	cyclin dependent kinase inhibitor 2A	Mus musculus	15-21
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Lysine	168-174	uncharacterized protein	Drosophila melanogaster	87-90
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	80-83	tumor protein p53	Homo sapiens	222-225
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53	Homo sapiens	88-91
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53	Homo sapiens	222-225
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53	Homo sapiens	88-91
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53	Homo sapiens	222-225
16689930-9	2006	We propose a model for co-ordinated changes in PC4 cofactor functions, mediated by phosphorylation status-dependent gradual masking of the lysine-rich region causing shielding or exposure of interaction surfaces.	Lysine	139-145	SUB1 regulator of transcription	Homo sapiens	47-50
16549805-2	2006	In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination of Lys-156 and Lys-158 in Insig-1.	Lysine	117-120	insulin induced gene 2	Homo sapiens	81-88
16416505-4	2006	The carrier was designed to have the structure of (KHKHKHKHKK)6-FGF2 where lysine (K) residues would allow complexation with plasmid DNA, basic fibroblast growth factor (FGF2) to target cells over-expressing FGF2 receptors (FGFR), and histidine (H) residues to facilitate escape from the endosomal compartments.	Lysine	75-81	fibroblast growth factor 2	Homo sapiens	64-68
16436515-4	2006	First, it induced the acetylation of p53 at lysine 320 and its dephosphorylation at serine 392 but not p53 activity.	Lysine	44-50	tumor protein p53	Homo sapiens	37-40
16547522-0	2006	Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].	Lysine	11-14	nuclear factor kappa B subunit 1	Homo sapiens	70-79
16547522-2	2006	Almost all NF-kappaB activation pathways converge on IkappaB kinase (IKK), which phosphorylates IkappaB resulting in Lys 48-linked polyubiquitination of IkappaB and its degradation.	Lysine	117-120	nuclear factor kappa B subunit 1	Homo sapiens	11-20
16479534-5	2006	In the case of calpain-2, a single iteration step involving LC-MS, provided the definitive residue specificity from which a highly sensitive fluorogenic substrate, (FAM)-Gly-Gly-Gly-Gln-Leu-Tyr-Gly-Gly-DPA-Arg-Arg-Lys-(TAMRA), was then designed.	Lysine	214-217	calpain 2	Homo sapiens	15-24
16537920-0	2006	Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).	Lysine	22-28	tumor protein p53	Homo sapiens	15-18
16537920-0	2006	Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).	Lysine	22-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	109-112
16537920-0	2006	Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).	Lysine	22-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	113-117
16537920-0	2006	Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).	Lysine	22-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	118-122
16537920-4	2006	That p53 was acetylated after depsipeptide treatment was tested by sequential immunoprecipitation/Western immunoblot analysis with anti-acetylated lysines and anti-p53 antibodies.	Lysine	147-154	tumor protein p53	Homo sapiens	5-8
16549805-2	2006	In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination of Lys-156 and Lys-158 in Insig-1.	Lysine	129-132	insulin induced gene 2	Homo sapiens	81-88
16428384-2	2006	Murine thrombin has Asp-222 in the Na+ binding site of the human enzyme replaced by Lys.	Lysine	84-87	coagulation factor II	Mus musculus	7-15
16428381-1	2006	Drosophila peptidoglycan recognition protein (PGRP)-LCx and -LCa are receptors that preferentially recognize meso-diaminopimelic acid (DAP)-type peptidoglycan (PGN) present in Gram-negative bacteria over lysine-type PGN of gram-positive bacteria and initiate the IMD signaling pathway, whereas PGRP-LE plays a synergistic role in this process of innate immune defense.	Lysine	204-210	Peptidoglycan recognition protein LE	Drosophila melanogaster	294-301
16543219-4	2006	Here we show that NuA4 acetylates Htz1 Lys 14 (K14) after the histone is assembled into chromatin by the SWR-C. K14 mutants exhibit specific defects in chromosome transmission without affecting transcription, telomeric silencing, or DNA repair.	Lysine	39-42	histone H2AZ	Saccharomyces cerevisiae S288C	34-38
16543144-2	2006	To elucidate the role of EGFR ubiquitination, tandem mass spectrometry was used to identify six distinct lysine residues within the kinase domain of the EGFR, which can be conjugated to ubiquitin following growth factor stimulation.	Lysine	105-111	epidermal growth factor receptor	Homo sapiens	25-29
16543144-2	2006	To elucidate the role of EGFR ubiquitination, tandem mass spectrometry was used to identify six distinct lysine residues within the kinase domain of the EGFR, which can be conjugated to ubiquitin following growth factor stimulation.	Lysine	105-111	epidermal growth factor receptor	Homo sapiens	153-157
16543144-3	2006	Substitution of these lysine residues with arginines resulted in a dramatic decrease in overall ubiquitination but preserved normal tyrosine phosphorylation of EGFR.	Lysine	22-28	epidermal growth factor receptor	Homo sapiens	160-164
16543150-3	2006	We find a stable association of the histone H4 lysine 16-specific acetyltransferase MOF with the RNA/protein containing MSL complex as well as with an evolutionary conserved complex.	Lysine	47-53	male-specific lethal 1	Drosophila melanogaster	120-123
16543223-4	2006	Using mass spectrometric analysis, we determined that Htz1 is acetylated at Lys 3, Lys 8, Lys 10, and Lys 14 within its N-terminal tail, with K14 being the most abundant acetylated site.	Lysine	76-79	histone H2AZ	Saccharomyces cerevisiae S288C	54-58
16543223-7	2006	In support of our genome-wide analysis, we found that the acetylatable lysines of Htz1 are required for its full deposition during nucleosome reassembly upon repression of PHO5.	Lysine	71-78	histone H2AZ	Saccharomyces cerevisiae S288C	82-86
16519522-3	2006	In this study, a recombinant purified SUV39H1 is used for substrate specificity and steady-state kinetic analysis with peptides representing the un- or dimethylated lysine 9 histone H3 tail or full-length human recombinant H3 (rH3).	Lysine	165-171	SUV39H1 histone lysine methyltransferase	Homo sapiens	38-45
16406070-4	2006	Bicoid is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the critical 50th position (K50) of the homeodomain sequence, a residue required for DNA and RNA recognition; Bcd also has an arginine residue at the 54th position (R54), which is essential for RNA recognition.	Lysine	85-91	bicoid	Drosophila melanogaster	0-6
16406070-4	2006	Bicoid is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the critical 50th position (K50) of the homeodomain sequence, a residue required for DNA and RNA recognition; Bcd also has an arginine residue at the 54th position (R54), which is essential for RNA recognition.	Lysine	85-91	bicoid	Drosophila melanogaster	213-216
16254126-7	2006	A synthetic tripalmitoylated cysteine-, serine-, and lysine-containing peptide (Pam) and LPS from Porphyromonas gingivalis, two TLR2 ligands, also stimulated IL-6 expression.	Lysine	53-59	interleukin 6	Mus musculus	158-162
16509590-6	2006	A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH.	Lysine	221-225	toll like receptor 2	Homo sapiens	106-110
16509590-6	2006	A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH.	Lysine	221-225	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
16503640-10	2006	Finally, cells lacking both Dot1p, the methyltransferase that methylates H3 lysine 79, and Cac1p, the large subunit of CAF-1, exhibited a dramatic loss of telomeric silencing and increased sensitivity to DNA damaging agents.	Lysine	76-82	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	28-33
16619521-8	2006	Pre-exposing T47D cells to Qu (25 microM) or LY (10 microM) abrogated EGF-induced Akt/PKB phosphorylation at Ser-473.	Lysine	45-47	AKT serine/threonine kinase 1	Homo sapiens	82-85
16619521-8	2006	Pre-exposing T47D cells to Qu (25 microM) or LY (10 microM) abrogated EGF-induced Akt/PKB phosphorylation at Ser-473.	Lysine	45-47	AKT serine/threonine kinase 1	Homo sapiens	86-89
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Lysine	187-190	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	50-53
16476977-7	2006	Thirdly, the requirement of the arginine and lysine clusters for Nef-mediated CD4 down modulation was shown to correlate precisely with membrane association.	Lysine	45-51	S100 calcium binding protein B	Homo sapiens	65-68
16476977-7	2006	Thirdly, the requirement of the arginine and lysine clusters for Nef-mediated CD4 down modulation was shown to correlate precisely with membrane association.	Lysine	45-51	CD4 molecule	Homo sapiens	78-81
16354653-3	2006	Previously, we found that in Selenomonas ruminantium, a strictly anaerobic and Gram-negative bacterium, a drastic degradation of lysine decarboxylase (LDC; EC 4.1.1.18), which has decarboxylase activities toward both L-lysine and L-ornithine with similar K(m) values, occurs upon entry into the stationary phase of cell growth by protease together with a protein of 22 kDa (P22).	Lysine	217-225	dynein cytoplasmic 1 heavy chain 1	Mus musculus	374-377
16356938-6	2006	The N-terminal domain of CtBP2 contains three Lys residues.	Lysine	46-49	C-terminal binding protein 2	Homo sapiens	25-30
16356938-8	2006	Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear to be acetylated, acetylation of Lys-10 is critical for nuclear localization.	Lysine	19-22	C-terminal binding protein 2	Homo sapiens	35-40
16356938-8	2006	Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear to be acetylated, acetylation of Lys-10 is critical for nuclear localization.	Lysine	42-45	C-terminal binding protein 2	Homo sapiens	35-40
16356938-8	2006	Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear to be acetylated, acetylation of Lys-10 is critical for nuclear localization.	Lysine	42-45	C-terminal binding protein 2	Homo sapiens	35-40
16356938-8	2006	Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear to be acetylated, acetylation of Lys-10 is critical for nuclear localization.	Lysine	42-45	C-terminal binding protein 2	Homo sapiens	35-40
16356938-8	2006	Although all three Lys residues of CtBP2 (Lys-6, Lys-8, and Lys-10) appear to be acetylated, acetylation of Lys-10 is critical for nuclear localization.	Lysine	42-45	C-terminal binding protein 2	Homo sapiens	35-40
16356938-9	2006	CtBP2 with a single amino acid substitution at Lys-10 (K10R) is predominantly localized in the cytoplasm.	Lysine	47-50	C-terminal binding protein 2	Homo sapiens	0-5
16356938-11	2006	Furthermore, lack of acetylation at Lys-10 renders CtBP2 to be more efficient in repression of the E-cadherin promoter.	Lysine	36-39	C-terminal binding protein 2	Homo sapiens	51-56
16356938-11	2006	Furthermore, lack of acetylation at Lys-10 renders CtBP2 to be more efficient in repression of the E-cadherin promoter.	Lysine	36-39	cadherin 1	Homo sapiens	99-109
16376303-1	2006	Mouse ARD1 (mARD1) has been reported to negatively regulate the hypoxia-inducible factor 1alpha (HIF-1alpha) protein by acetylating a lysine residue and enhancing HIF-1alpha ubiquitination and degradation.	Lysine	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-95
16376303-1	2006	Mouse ARD1 (mARD1) has been reported to negatively regulate the hypoxia-inducible factor 1alpha (HIF-1alpha) protein by acetylating a lysine residue and enhancing HIF-1alpha ubiquitination and degradation.	Lysine	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
16583725-10	2006	This G to A transition changes a highly conserved glutamic acid residue to a lysine residue in domain II S2 of the P/Q-type calcium channel alpha1A subunit.	Lysine	77-83	serpin family A member 1	Homo sapiens	140-147
16451070-6	2006	A protracted glucose-lowering effect was observed 24 h following GIP(Lys(37)PAL) administration.	Lysine	69-72	gastric inhibitory polypeptide	Mus musculus	65-68
16139409-11	2006	The oxygen-dependent HIF-1alpha regulation requiring both proline hydroxylation and lysine acetylation may be more complicated than the iron-dependent regulation requiring only proline hydroxylation.	Lysine	84-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
16497154-6	2006	The receptor binds [3H]Lys-des-Arg9-bradykinin in a saturable manner (K(d) 0.36 nM) and exhibits a pharmacological profile similar to that of human B(1)R.	Lysine	23-26	kininogen 1	Homo sapiens	36-46
16272441-2	2006	Tbeta(4) binding increases the distance between probes attached to Gln-41 and Cys-374 of actin by 2 A and decreases the distance between the purine base of bound ATP (epsilonATP) and Lys-61 by 1.9 A, whereas the distance between Cys-374 and Lys-61 is minimally affected.	Lysine	183-186	thymosin beta 4 X-linked	Homo sapiens	0-8
16272441-2	2006	Tbeta(4) binding increases the distance between probes attached to Gln-41 and Cys-374 of actin by 2 A and decreases the distance between the purine base of bound ATP (epsilonATP) and Lys-61 by 1.9 A, whereas the distance between Cys-374 and Lys-61 is minimally affected.	Lysine	241-244	thymosin beta 4 X-linked	Homo sapiens	0-8
16427628-2	2006	We showed that all RET-PTC-1 mutants in which the C in this motif (C376) was replaced with glycine, lysine, threonine or serine lost their activity in vitro.	Lysine	100-106	patched 1	Homo sapiens	23-28
16417904-0	2006	Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine.	Lysine	124-130	myeloperoxidase	Homo sapiens	0-15
16467084-9	2006	Purified hK11 possesses trypsin-like activity and cleaves synthetic peptides after arginine but not lysine residues.	Lysine	100-106	kallikrein related peptidase 11	Homo sapiens	9-13
16322504-5	2006	Using a chromatin immunoprecipitation method we demonstrate that the dramatic increase of patatin gene expression during the transition from stolons to tubers coincides with an increase of histone H4 lysine acetylation.	Lysine	200-206	Patatin class I	Solanum tuberosum	90-97
16441657-5	2006	A subgroup of beta-ketoacyl-ACP synthases, including mitochondrial beta-ketoacyl-ACP synthase, bacterial plus plastid beta-ketoacyl-ACP synthases I and II, and a domain of human fatty acid synthase, have a Cys-His-His triad and also a completely conserved Lys in the active site.	Lysine	256-259	3-oxoacyl-ACP synthase, mitochondrial	Homo sapiens	14-40
16406639-1	2006	The effect of a lysine-deficient diet on cationic amino acid transporter (CAT1-3) mRNA expression was determined in broiler chickens.	Lysine	16-22	solute carrier family 7 member 1	Gallus gallus	74-80
16406639-7	2006	The summed amount of high affinity CAT-1 and CAT-3 mRNA expression in chicks fed a lysine adequate diet was highly correlated (r2=0.51; P&lt;0.001) to a tissue"s growth during a lysine deficiency or feed restriction.	Lysine	83-89	solute carrier family 7 member 1	Gallus gallus	35-40
16406639-7	2006	The summed amount of high affinity CAT-1 and CAT-3 mRNA expression in chicks fed a lysine adequate diet was highly correlated (r2=0.51; P&lt;0.001) to a tissue"s growth during a lysine deficiency or feed restriction.	Lysine	178-184	solute carrier family 7 member 1	Gallus gallus	35-40
16452303-3	2006	In the first step, deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the epsilon-amino group of one specific lysine residue of the eIF5A precursor to form a deoxyhypusine intermediate.	Lysine	176-182	deoxyhypusine synthase	Homo sapiens	19-41
16293626-0	2006	DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines.	Lysine	116-123	tumor protein p53	Homo sapiens	101-104
16449638-8	2006	Neddylation of Cul3 on Lys 712 is required for Keap1-dependent ubiquitination of Nrf2 in vivo.	Lysine	23-26	kelch like ECH associated protein 1	Homo sapiens	47-52
16449638-8	2006	Neddylation of Cul3 on Lys 712 is required for Keap1-dependent ubiquitination of Nrf2 in vivo.	Lysine	23-26	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
16449642-5	2006	This effect is mediated by the previously described association of PML-RAR with chromatin-modifying enzymes (histone deacetylases and DNA methyltransferases) and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3.	Lysine	253-259	SUV39H1 histone lysine methyltransferase	Homo sapiens	210-217
16321856-6	2006	The c-kit mutations in exon 11 occurred at codon 558 (AAG --&gt; TAG; Lys --&gt; Stop) and at codon 571 (CTA --&gt; ATA; Leu --&gt; Ile), respectively, while the mutation in exon 13 occurred at codon 634 (CGG --&gt; CGA; Arg --&gt; Arg).	Lysine	70-73	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
16339075-8	2006	The reloading defect observed in Brd4+/- cells coincided with selective hypoacetylation of lysine residues on H3 and H4.	Lysine	91-97	bromodomain containing 4	Homo sapiens	33-37
16293626-5	2006	The C-terminal lysines of p53, which are acetylated and methylated, are required for HDAC4 recruitment and transcriptional repression.	Lysine	15-22	tumor protein p53	Homo sapiens	26-29
16337145-9	2006	Our study shows that ZNF76, a TBP-interacting transcriptional modulator, is regulated by both lysine modifications and alternative splicing.	Lysine	94-100	zinc finger protein 76	Homo sapiens	21-26
16519407-2	2006	L-lysine ligand was coupled to the spacer and its selective affinity for low-density lipoprotein-cholesterol (LDL-C) was determined.	Lysine	0-8	component of oligomeric golgi complex 2	Homo sapiens	73-108
16291740-2	2006	Upon p53 activation, however, these lysines become acetylated by p300/CREB-binding protein.	Lysine	36-43	CREB binding protein	Homo sapiens	70-90
16291740-4	2006	This activity is independent of MDM2 but requires a p53 nuclear export signal and acetylation of multiple lysines by p300.	Lysine	106-113	tumor protein p53	Homo sapiens	52-55
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-77	tumor protein p53	Homo sapiens	129-132
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-77	tumor protein p53	Homo sapiens	209-212
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-76	tumor protein p53	Homo sapiens	129-132
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-76	tumor protein p53	Homo sapiens	209-212
16291740-6	2006	Our study suggested a threshold mechanism whereby the degree of acetylation regulates p53 nucleus-cytoplasm trafficking by neutralizing a lysine-dependent charge patch, which in turn, controls oligomerization-dependent p53 nuclear export.	Lysine	138-144	tumor protein p53	Homo sapiens	86-89
16291740-6	2006	Our study suggested a threshold mechanism whereby the degree of acetylation regulates p53 nucleus-cytoplasm trafficking by neutralizing a lysine-dependent charge patch, which in turn, controls oligomerization-dependent p53 nuclear export.	Lysine	138-144	tumor protein p53	Homo sapiens	219-222
16409643-5	2006	Here we examined the ability of Tax to interact with a histone methyltransferase SUV39H1 that methylates histone H3 lysine 9 (H3K9) and represses transcription of genes, and studied the functional effects of the interaction on HTLV-1 gene expression.	Lysine	116-122	SUV39H1 histone lysine methyltransferase	Homo sapiens	81-88
16148030-3	2006	Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin suppressed both thrombin-induced VSMC DNA synthesis and migration.	Lysine	44-46	AKT serine/threonine kinase 1	Homo sapiens	17-20
16148030-3	2006	Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin suppressed both thrombin-induced VSMC DNA synthesis and migration.	Lysine	44-46	mechanistic target of rapamycin kinase	Homo sapiens	21-25
16148030-3	2006	Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin suppressed both thrombin-induced VSMC DNA synthesis and migration.	Lysine	44-46	coagulation factor II, thrombin	Homo sapiens	85-93
16291740-0	2006	Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.	Lysine	43-49	tumor protein p53	Homo sapiens	69-72
16291740-1	2006	The basal level of the tumor suppressor p53 is regulated by MDM2-mediated ubiquitination at specific lysines, which leads to p53 nuclear export and degradation.	Lysine	101-108	tumor protein p53	Homo sapiens	40-43
16291740-1	2006	The basal level of the tumor suppressor p53 is regulated by MDM2-mediated ubiquitination at specific lysines, which leads to p53 nuclear export and degradation.	Lysine	101-108	tumor protein p53	Homo sapiens	125-128
16291740-2	2006	Upon p53 activation, however, these lysines become acetylated by p300/CREB-binding protein.	Lysine	36-43	tumor protein p53	Homo sapiens	5-8
16284078-0	2006	An amino-terminal lysine residue of rat connexin40 that is required for spermine block.	Lysine	18-24	gap junction protein, alpha 5	Rattus norvegicus	40-50
16519407-2	2006	L-lysine ligand was coupled to the spacer and its selective affinity for low-density lipoprotein-cholesterol (LDL-C) was determined.	Lysine	0-8	component of oligomeric golgi complex 2	Homo sapiens	110-115
16495141-3	2006	Acetylation of lysine residues lowered the isoelectric point of apoAI, altered its secondary and tertiary structure, and led to a 40% decrease in cholesterol acceptor activity, while maintaining 93% of its lipid binding activity.	Lysine	15-21	apolipoprotein A1	Homo sapiens	64-69
16495141-0	2006	Apolipoprotein A-I lysine modification: effects on helical content, lipid binding and cholesterol acceptor activity.	Lysine	19-25	apolipoprotein A1	Homo sapiens	0-18
16495141-4	2006	Exhaustive lysine acetoacetylation lowered apoAI"s isoelectric point, profoundly disrupted its secondary and tertiary structure, and led to 90% and 82% reductions in cholesterol acceptor and lipid binding activities, respectively.	Lysine	11-17	apolipoprotein A1	Homo sapiens	43-48
16495141-1	2006	We examined the role of the positively charged lysine residues in apoAI by chemical modification.	Lysine	47-53	apolipoprotein A1	Homo sapiens	66-71
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	73-79	apolipoprotein A1	Homo sapiens	67-72
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	73-79	apolipoprotein A1	Homo sapiens	222-227
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	228-234	apolipoprotein A1	Homo sapiens	67-72
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	228-234	apolipoprotein A1	Homo sapiens	222-227
16497162-8	2006	The decreased affinity displayed by the ATH1 homeodomain correlates with the presence of valine (instead of lysine as in STM) at position 54.	Lysine	108-114	homeobox protein ATH1	Arabidopsis thaliana	40-44
16426974-1	2006	Lysine acetylation of human tumor suppressor p53 in response to cellular stress signals is required for its function as a transcription factor that regulates cell cycle arrest, senescence, or apoptosis.	Lysine	0-6	tumor protein p53	Homo sapiens	45-48
17106577-4	2006	We found that the ability of peptides to block Abeta channel activity could be lost by replacement of histidines 13 and 14 by alanine or lysine.	Lysine	137-143	amyloid beta precursor protein	Homo sapiens	47-52
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Lysine	298-301	endothelin 1	Homo sapiens	38-42
15976810-2	2006	Here, we report that DJ-1 was sumoylated on a lysine residue at amino-acid number 130 (K130) by PIASxalpha or PIASy.	Lysine	46-52	protein inhibitor of activated STAT 2	Homo sapiens	96-106
16426974-2	2006	Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage.	Lysine	43-49	tumor protein p53	Homo sapiens	65-68
16426974-2	2006	Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage.	Lysine	43-49	CREB binding protein	Homo sapiens	121-124
16426974-2	2006	Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage.	Lysine	43-49	tumor protein p53	Homo sapiens	155-158
16546436-8	2006	Protein mutation analysis revealed that a Lys-rich motif of N protein acted as a nuclear localization signal and was essential for the activation of COX-2.	Lysine	42-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
16403019-7	2006	Furthermore, we show by in vitro binding assays that AIRE interacts with multiple members of the nuclear transport receptor importin alpha family, mainly alpha1, alpha3, and alpha5, and that these interactions depend on the intactness of the Arg-Lys-rich NLS of AIRE.	Lysine	246-249	autoimmune regulator	Homo sapiens	53-57
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Lysine	201-204	tumor necrosis factor	Homo sapiens	13-16
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Lysine	201-204	tumor necrosis factor	Homo sapiens	51-54
16753968-3	2006	On the contrary, (a) when phosphatidylserine vesicles were used, lysozyme induces an increase of turbidity and a shift toward larger vesicle sizes; and (b) the addition of histone H1 or poly-L-lysine produces an aggregative behavior both in oleate and in phosphatidylserine vesicles.	Lysine	186-199	lysozyme	Homo sapiens	65-73
16354696-5	2006	However, depletion of Paf1 reduces trimethylation of histone H3 at lysine 4 in the Hsp70 promoter region and significantly decreases the recruitment of chromatin-associated factors Spt6 and FACT, suggesting that Paf1 may manifest its effects on transcription through modulating chromatin structure.	Lysine	67-73	antimeros	Drosophila melanogaster	22-26
16354677-3	2006	Treatment with EX-527 dramatically increased acetylation at lysine 382 of p53 after different types of DNA damage in primary human mammary epithelial cells and several cell lines.	Lysine	60-66	tumor protein p53	Homo sapiens	74-77
16210244-5	2006	In this study we used green fluorescent protein-tagged macroH2A1.2 to determine that Lys(115) is a site of ubiquitination.	Lysine	85-88	macroH2A.1 histone	Homo sapiens	55-66
16407062-6	2006	The second, more flexible repeat is responsible for interacting both with methylated lysine and with 82-FIP, one of the FMRP nuclear partners.	Lysine	85-91	fragile X messenger ribonucleoprotein 1	Homo sapiens	120-124
16446403-3	2006	Lysine residues at the COOH-terminal region of p53 are implicated as sites for ubiquitination and other post-translational modifications.	Lysine	0-6	tumor protein p53	Homo sapiens	47-50
16446403-8	2006	In contrast, several conserved lysine residues in the DNA-binding domain are critical for p53 ubiquitination.	Lysine	31-37	tumor protein p53	Homo sapiens	90-93
16877877-11	2006	Thrombin activatable fibrinolysis inhibitor is a carboxypeptidase that cleaves the carboxylic lysine residues on fibrin, thereby abolishing the critical binding site for tPA-plasminogen decreasing plasmin formation.	Lysine	94-100	coagulation factor II, thrombin	Homo sapiens	0-8
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	96-99	protein inhibitor of activated STAT 3	Homo sapiens	41-46
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	103-106	protein inhibitor of activated STAT 3	Homo sapiens	41-46
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	103-106	protein inhibitor of activated STAT 3	Homo sapiens	41-46
16344468-1	2005	In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating cell nuclear antigen (PCNA) at Lys-164.	Lysine	157-160	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	36-41
16222244-3	2005	For example, heterochromatin protein 1 (HP1) binds to histone H3 when its lysine 9 residue has been tri-methylated by the methyltransferase Suv39h (refs 2-6).	Lysine	74-80	SUV39H1 histone lysine methyltransferase	Homo sapiens	140-146
16337599-3	2005	hBRE1 specifically increases the global level of H2B ubiquitylation at lysine 120 and enhances activator-dependent transcription.	Lysine	71-77	ring finger protein 20	Homo sapiens	0-5
16204234-4	2005	Here we show that PARP-1 is acetylated in vivo at specific lysine residues by p300/CREB-binding protein upon stimulation.	Lysine	59-65	poly(ADP-ribose) polymerase 1	Homo sapiens	18-24
16204234-4	2005	Here we show that PARP-1 is acetylated in vivo at specific lysine residues by p300/CREB-binding protein upon stimulation.	Lysine	59-65	CREB binding protein	Homo sapiens	83-103
16288922-7	2005	Moreover, our structure-based analysis reveals that individual mutation of the conserved Arg294 and Arg295 that likely comprise the phosphothreonine-binding pocket in PAC-1 to either alanine or lysine results in a nearly complete loss of its phosphatase activity even in the presence of ERK2.	Lysine	194-200	mitogen-activated protein kinase 1	Homo sapiens	287-291
16155004-4	2005	Based on the solution structure of HB-GAM, we have recently shown that HB-GAM consists of two beta-sheet domains flanked by flexible lysine-rich N- and C-terminal tails with no apparent structure.	Lysine	133-139	pleiotrophin	Homo sapiens	71-77
16122376-8	2005	Furthermore, peptides containing lysine at position -2 or -3 N-terminal to the target tyrosine were found to be poor EGFR kinase substrates, and substitution of these lysines with glutamine decreased the K(m) and increased the k(cat) for these substrates.	Lysine	33-39	epidermal growth factor receptor	Homo sapiens	117-121
16332963-4	2005	Metnase methylates histone H3 lysines 4 and 36, which are associated with open chromatin.	Lysine	30-37	SET domain and mariner transposase fusion gene	Homo sapiens	0-7
16207715-5	2005	In vivo sumoylation assays confirmed that lysines 244, 263, and 353 of PLAG1 and lysines 250, 269, and 356 of PLAGL2 are indeed sumoylation sites.	Lysine	42-49	PLAG1 zinc finger	Homo sapiens	71-76
16207715-11	2005	Finally, mutation of three lysine residues in sumoylation motifs significantly impairs the transformation ability of PLAG1 and PLAGL2, suggesting the essential roles of these sites in the oncogenic potential of PLAG proteins.	Lysine	27-33	PLAG1 zinc finger	Homo sapiens	117-122
16245011-4	2005	The ADGF proteins share a novel amino acid motif, "MPKG," within which the proline and lysine residues are also conserved in the ADAL and ADA subfamilies.	Lysine	87-93	adenosine deaminase like	Homo sapiens	129-133
16306263-5	2005	To validate this concept, we prepared a low-density lipoprotein (LDL)-based folate receptor (FR)-targeted agent by conjugating folic acid to the Lys residues of the apolipoprotein B (apoB)-100 protein.	Lysine	145-148	apolipoprotein B	Homo sapiens	165-192
16246115-2	2005	In presynaptic nerve termini, RIM1alpha interacts with a series of presynaptic proteins, including the synaptic vesicle GTPase Rab3 and the active zone proteins Munc13, liprins and ELKS (a protein rich in glutamate, leucine, lysine and serine).	Lysine	225-231	regulating synaptic membrane exocytosis 1	Mus musculus	30-39
16260194-4	2005	In yeast, the homolog of DPY-30, Saf19p, functions as a member of histone 3 lysine 4 methylation complex, which is the key part of epigenetic developmental control.	Lysine	76-82	Sdc1p	Saccharomyces cerevisiae S288C	33-39
16316977-8	2005	Substitution of the lysine by serine or aspartate abolished the "open-lock" characteristic and converted AKT2 into an inward-rectifying channel.	Lysine	20-26	potassium transport 2/3	Arabidopsis thaliana	105-109
16316977-10	2005	We conclude that the lysine residue K197 sensitizes AKT2 to phosphoregulation.	Lysine	21-27	potassium transport 2/3	Arabidopsis thaliana	52-56
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Lysine	170-176	estrogen receptor 1	Homo sapiens	156-163
16183991-4	2005	Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway.	Lysine	73-79	amyloid beta precursor protein	Homo sapiens	30-35
16183991-4	2005	Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway.	Lysine	73-79	nuclear factor kappa B subunit 1	Homo sapiens	105-114
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Lysine	170-176	MYB binding protein 1a	Homo sapiens	330-334
16380505-5	2005	We show that BMP-2 induces the phosphorylation of mTOR in A549 and H1299 lung cancer cell lines, which is attenuated by the PI3K antagonists LY-294002 and wortmannin.	Lysine	141-143	mechanistic target of rapamycin kinase	Homo sapiens	50-54
16287851-3	2005	By in vitro sumoylation reaction and DNA transfection experiments, we show that the sumoylation occurs at lysine 368 (K368) of human p45/NF-E2.	Lysine	106-112	nuclear factor, erythroid 2	Homo sapiens	133-142
16287853-0	2005	Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.	Lysine	56-62	nuclear factor kappa B subunit 1	Homo sapiens	80-89
16422104-2	2005	The recombinant human tumor necrosis factor-alpha monoclonal antibody (rHTNF-alpha McAb) was wrapped on the polystyrene microsphere (PSM) carrier connecting poly-L-lysine (PLL) beforehand.	Lysine	157-170	tumor necrosis factor	Homo sapiens	22-49
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	31-37	Atg19p	Saccharomyces cerevisiae S288C	0-6
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	31-37	Atg19p	Saccharomyces cerevisiae S288C	118-124
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	48-51	Atg19p	Saccharomyces cerevisiae S288C	0-6
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	48-51	Atg19p	Saccharomyces cerevisiae S288C	118-124
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	61-64	Atg19p	Saccharomyces cerevisiae S288C	0-6
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	61-64	Atg19p	Saccharomyces cerevisiae S288C	118-124
16307923-8	2005	RNF20 overexpression leads to elevated H2B monoubiquitination, subsequently higher levels of methylation at H3 lysines 4 and 79, and stimulation of HOX gene expression.	Lysine	111-118	ring finger protein 20	Homo sapiens	0-5
16287980-2	2005	Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine residues 999, 1034, and 1057 both in vitro and in vivo.	Lysine	192-198	CREB binding protein	Homo sapiens	19-39
16287980-2	2005	Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine residues 999, 1034, and 1057 both in vitro and in vivo.	Lysine	192-198	CREB binding protein	Homo sapiens	41-44
16287980-3	2005	Mutation of the SUMO acceptor lysine residues either individually or in combination enhanced CBP transcriptional activity, and expression of a SUMO protease SENP2 potentiated the transcriptional activity of CBP wild-type but not its sumoylation mutant, indicating that SUMO modification negatively regulates CBP transcriptional activity.	Lysine	30-36	CREB binding protein	Homo sapiens	93-96
16307923-9	2005	In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression.	Lysine	127-134	ring finger protein 20	Homo sapiens	30-35
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	79-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-29
16274242-0	2005	Thermodynamics and kinetics of formation of the alkaline state of a Lys 79--&gt;Ala/Lys 73--&gt;His variant of iso-1-cytochrome c.	Lysine	68-71	cytochrome c, somatic	Homo sapiens	117-129
16274242-0	2005	Thermodynamics and kinetics of formation of the alkaline state of a Lys 79--&gt;Ala/Lys 73--&gt;His variant of iso-1-cytochrome c.	Lysine	84-87	cytochrome c, somatic	Homo sapiens	117-129
16274242-1	2005	The alkaline transition kinetics of a Lys 73--&gt;His (H73) variant of iso-1-cytochrome c are triggered by three ionizable groups [Martinez, R. E., and Bowler, B. E. (2004) J.	Lysine	38-41	cytochrome c, somatic	Homo sapiens	77-89
16147996-9	2005	Inhibition of this binding by acetylation and cyclohexanedione treatment of LDL showed that the positively charged amino acids of apolipoprotein B-100, lysine, and arginine, respectively, mediated the ionic interaction.	Lysine	152-158	apolipoprotein B	Homo sapiens	130-150
16271867-5	2005	Histone H3 methylation at lysine 4 was increased and histone H3 methylation at lysine 9 was decreased at the 35S promoter in the ros1rpa2 mutant compared to the ros1 background.	Lysine	79-85	demeter-like 1	Arabidopsis thaliana	129-137
16271867-5	2005	Histone H3 methylation at lysine 4 was increased and histone H3 methylation at lysine 9 was decreased at the 35S promoter in the ros1rpa2 mutant compared to the ros1 background.	Lysine	79-85	demeter-like 1	Arabidopsis thaliana	129-133
16286008-0	2005	Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.	Lysine	49-55	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	81-85
16275913-1	2005	WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion transport pathways to maintain homeostasis during physiological perturbation.	Lysine	28-34	WNK lysine deficient protein kinase 1 S homeolog	Xenopus laevis	0-4
16148010-5	2005	Both PIASxalpha/ARIP3 and the closely related PIASxbeta isoform specifically enhanced sumoylation of FLI-1 at Lys(67), located in its N-terminal activation domain.	Lysine	110-113	protein inhibitor of activated STAT 2	Homo sapiens	5-15
16148010-5	2005	Both PIASxalpha/ARIP3 and the closely related PIASxbeta isoform specifically enhanced sumoylation of FLI-1 at Lys(67), located in its N-terminal activation domain.	Lysine	110-113	protein inhibitor of activated STAT 2	Homo sapiens	16-21
16148010-5	2005	Both PIASxalpha/ARIP3 and the closely related PIASxbeta isoform specifically enhanced sumoylation of FLI-1 at Lys(67), located in its N-terminal activation domain.	Lysine	110-113	protein inhibitor of activated STAT 2	Homo sapiens	46-55
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	79-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-34
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	79-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-39
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	153-159	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-29
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	153-159	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-34
16262255-9	2005	Furthermore, we show that p21(Cip1/WAF1) can be ubiquitinated at four distinct lysine residues located in the carboxyl-terminal region but not two other lysine residues in the N-terminal region.	Lysine	153-159	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-39
16269333-2	2005	Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain.	Lysine	99-105	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	42-48
16176806-7	2005	However, the phosphorylation of c-Jun NH(2)-terminal kinase 1 (JNK1) was found to increase in both triptolide- and LY-294002-treated cells.	Lysine	115-117	mitogen-activated protein kinase 8	Homo sapiens	32-61
16176806-7	2005	However, the phosphorylation of c-Jun NH(2)-terminal kinase 1 (JNK1) was found to increase in both triptolide- and LY-294002-treated cells.	Lysine	115-117	mitogen-activated protein kinase 8	Homo sapiens	63-67
16135513-0	2005	Role of an S4-S5 linker lysine in the trafficking of the Ca(2+)-activated K(+) channels IK1 and SK3.	Lysine	24-30	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	88-91
15944210-10	2005	Rapid ERK1/2 activation that preceded FAK and paxillin activation was detected upon VSM cell adhesion to poly-l-lysine, and this response was inhibited by CaMKII gene silencing.	Lysine	105-118	mitogen-activated protein kinase 3	Homo sapiens	6-12
16336179-5	2005	We applied a chemical cross-linking technique to study the proximity of some Lys and Cys residues of NF-kappaB p50 subunit with certain reactive nucleotides into its recognition site.	Lysine	77-80	nuclear factor kappa B subunit 1	Homo sapiens	101-114
16012169-6	2005	Matrix-assisted laser desorption ionization time-of-flight analysis revealed that Lys-22, Lys-27, His-33, and Lys-87 cyt c residues were the main targets for carbethoxylation performed at low pH values (&lt;7.5).	Lysine	82-85	cytochrome c, somatic	Homo sapiens	117-122
16222728-4	2005	Muramyl dipeptide (1, MDP), the DAP-containing muramyl tripeptide 3, and the lysine-containing muramyl tripeptides 4 and 5 induced TNF-alpha gene expression without TNF-alpha protein production in a human monocytic cell line.	Lysine	77-83	tumor necrosis factor	Homo sapiens	131-140
16285960-6	2005	RESULTS: Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 terminus are acetylated by p300.	Lysine	13-16	signal transducer and activator of transcription 3	Mus musculus	58-63
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	signal transducer and activator of transcription 3	Mus musculus	28-33
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	signal transducer and activator of transcription 3	Mus musculus	122-127
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	interleukin 6	Mus musculus	152-156
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	angiotensinogen	Homo sapiens	165-169
16126721-4	2005	Tandem mass spectrometric analysis demonstrated that lysine 226, located near the center of helix 10 in apoA-I, was the major site modified by acrolein.	Lysine	53-59	apolipoprotein A1	Homo sapiens	104-110
16126721-7	2005	In the crystal structure of truncated apoA-I, Glu-234 lies adjacent to Lys-226, suggesting that negatively charged residues might direct the modification of specific lysine residues in proteins.	Lysine	71-74	apolipoprotein A1	Homo sapiens	38-44
16126721-7	2005	In the crystal structure of truncated apoA-I, Glu-234 lies adjacent to Lys-226, suggesting that negatively charged residues might direct the modification of specific lysine residues in proteins.	Lysine	166-172	apolipoprotein A1	Homo sapiens	38-44
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	96-99	coagulation factor II, thrombin	Homo sapiens	13-21
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	118-121	coagulation factor II, thrombin	Homo sapiens	13-21
15961505-6	2005	Using a series of mutants, we demonstrated that ERalpha is sumoylated at conserved lysine residues within the hinge region.	Lysine	83-89	estrogen receptor 1	Homo sapiens	48-55
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Lysine	9-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	161-164
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Lysine	9-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-169
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Lysine	9-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	170-174
16087677-9	2005	In thrombin proteolysates of the syndecan-4 ectodomain, the cleavage site Lys(114) downward arrowArg(115) was also identified.	Lysine	74-77	coagulation factor II, thrombin	Homo sapiens	3-11
16012169-8	2005	Thus, at low pH, protonation of these invariant and highly conserved amino acid residues produced a second positively charged region opposite to the Lys-72 and Lys-73 region in the cyt c structure.	Lysine	149-152	cytochrome c, somatic	Homo sapiens	181-186
16012169-8	2005	Thus, at low pH, protonation of these invariant and highly conserved amino acid residues produced a second positively charged region opposite to the Lys-72 and Lys-73 region in the cyt c structure.	Lysine	160-163	cytochrome c, somatic	Homo sapiens	181-186
16091367-11	2005	MPO-induced modification also targeted apoAI tryptophan and lysine residues.	Lysine	60-66	myeloperoxidase	Homo sapiens	0-3
16224021-0	2005	Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.	Lysine	63-69	AKT serine/threonine kinase 1	Homo sapiens	0-3
16224021-0	2005	Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.	Lysine	63-69	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
16224021-1	2005	Enhancer of Zeste homolog 2 (EZH2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3.	Lysine	152-158	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
16224021-1	2005	Enhancer of Zeste homolog 2 (EZH2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3.	Lysine	152-158	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
16224021-2	2005	Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes.	Lysine	173-179	AKT serine/threonine kinase 1	Homo sapiens	19-22
16224021-2	2005	Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	38-42
16224021-2	2005	Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	114-118
16007161-3	2005	Based on the differential effects of HBx natural variants, we determined that Lys-130 in the transactivation domain of HBx is critical for the E-cadherin repression.	Lysine	78-81	cadherin 1	Homo sapiens	143-153
16195383-6	2005	Chromatin immunoprecipitation studies reveal that menin directly associates with regions of the p27 and p18 promoters and increases methylation of lysine 4 (Lys-4) in histone H3 associated with these promoters.	Lysine	147-153	multiple endocrine neoplasia 1	Mus musculus	50-55
16195383-6	2005	Chromatin immunoprecipitation studies reveal that menin directly associates with regions of the p27 and p18 promoters and increases methylation of lysine 4 (Lys-4) in histone H3 associated with these promoters.	Lysine	157-160	multiple endocrine neoplasia 1	Mus musculus	50-55
16195383-7	2005	Moreover, H3 Lys-4 methylation associated with p27 and p18 is reduced in islet tumors from Men1 mutant mice.	Lysine	13-16	multiple endocrine neoplasia 1	Mus musculus	91-95
16162643-0	2005	Structure-sweetness relationship in egg white lysozyme: role of lysine and arginine residues on the elicitation of lysozyme sweetness.	Lysine	64-70	lysozyme	Homo sapiens	46-54
16096638-4	2005	Snail"s lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT.	Lysine	8-14	snail family transcriptional repressor 1	Homo sapiens	0-5
16096638-4	2005	Snail"s lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT.	Lysine	8-14	snail family transcriptional repressor 1	Homo sapiens	53-58
16096638-4	2005	Snail"s lysine residues 98 and 137 are essential for Snail stability, functional cooperation with LOXL2/3 and induction of EMT.	Lysine	8-14	lysyl oxidase like 2	Homo sapiens	98-103
16123593-9	2005	Cyclin A lacking the three lysine residues was degraded slower than the wild-type protein.	Lysine	27-33	cyclin A2	Homo sapiens	0-8
16162643-0	2005	Structure-sweetness relationship in egg white lysozyme: role of lysine and arginine residues on the elicitation of lysozyme sweetness.	Lysine	64-70	lysozyme	Homo sapiens	115-123
16162643-3	2005	Alanine substitution of lysine residues demonstrated that two out of six lysine residues, Lys13 and Lys96, are required for lysozyme sweetness, while the remaining four lysine residues do not play a significant role in the perception of sweetness.	Lysine	73-79	lysozyme	Homo sapiens	124-132
16162643-3	2005	Alanine substitution of lysine residues demonstrated that two out of six lysine residues, Lys13 and Lys96, are required for lysozyme sweetness, while the remaining four lysine residues do not play a significant role in the perception of sweetness.	Lysine	73-79	lysozyme	Homo sapiens	124-132
16191191-5	2005	In contrast to Cdk2-cyclin A, which has a well-defined consensus target site ((S/T)PX(K/R)) that strongly favors substrates containing a lysine at the +3 position of substrates, Cdk2-Speedy/Ringo A2 displayed a broad substrate specificity at this position.	Lysine	137-143	cyclin A2	Homo sapiens	20-28
16179605-5	2005	We found that mutation of the conserved arginine at position 179 of the PLD1 PX domain to lysine or to alanine (R179A or R179K, respectively) disrupts PtdIns(3,4,5)P3 binding.	Lysine	90-96	phospholipase D1	Homo sapiens	72-76
16166626-3	2005	Mutations that affect Dot1 function such as Rad6-Bre1/Paf1 pathway gene deletions or mutation of H2B Lys 123 or H3 Lys 79 share dot1Delta checkpoint defects.	Lysine	101-104	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	22-26
16166626-3	2005	Mutations that affect Dot1 function such as Rad6-Bre1/Paf1 pathway gene deletions or mutation of H2B Lys 123 or H3 Lys 79 share dot1Delta checkpoint defects.	Lysine	115-118	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	22-26
16166626-6	2005	In human cells, H3 Lys 79 methylation by hDOT1L likely mediates recruitment of the signaling protein 53BP1 via its paired tudor domains to double-strand breaks (DSBs).	Lysine	19-22	DOT1 like histone lysine methyltransferase	Homo sapiens	41-47
16166626-6	2005	In human cells, H3 Lys 79 methylation by hDOT1L likely mediates recruitment of the signaling protein 53BP1 via its paired tudor domains to double-strand breaks (DSBs).	Lysine	19-22	BP1	Homo sapiens	103-106
16227196-11	2005	Epsilon aminocaproic acid and tranexamic acid are lysine analogs that reduce bleeding by inhibiting the conversion of plasminogen to plasmin, a serine protease responsible for breaking down fibrinogen to fibrin.	Lysine	50-56	coagulation factor II, thrombin	Homo sapiens	144-159
16091423-9	2005	Alignment of the amino acid sequence of the intracellular part of the four FGFRs revealed several lysines conserved in FGFR1-3 but absent in FGFR4.	Lysine	98-105	fibroblast growth factor receptor 1	Homo sapiens	119-124
16122695-7	2005	The interaction between CtBP and CBP is functionally important and leads to impairment of histone H3 acetylation by CBP at specific lysine residues (Lys9, Lys14, and Lys18) in a dose-dependent and NADH-dependent manner.	Lysine	132-138	CREB binding protein	Homo sapiens	33-36
16122695-7	2005	The interaction between CtBP and CBP is functionally important and leads to impairment of histone H3 acetylation by CBP at specific lysine residues (Lys9, Lys14, and Lys18) in a dose-dependent and NADH-dependent manner.	Lysine	132-138	CREB binding protein	Homo sapiens	116-119
16131544-2	2005	Competitive binding analysis and mutagenesis reveals a unique BTLA binding site centered on a critical lysine residue in cysteine-rich domain 1 of HVEM.	Lysine	103-109	TNF receptor superfamily member 14	Homo sapiens	147-151
16148131-3	2005	In this study we present evidence that the hyporesponsiveness of the human iNOS promoter is based in part on epigenetic silencing, specifically hypermethylation of CpG dinucleotides and histone H3 lysine 9 methylation.	Lysine	197-203	nitric oxide synthase 2	Homo sapiens	75-79
16148131-8	2005	Using chromatin immunoprecipitation, we found that the human iNOS promoter was basally enriched with di- and trimethylation of H3 lysine 9 in endothelial cells, and this did not change with cytokine addition.	Lysine	130-136	nitric oxide synthase 2	Homo sapiens	61-65
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	140-144
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	interleukin 4	Homo sapiens	218-221
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	interleukin 13	Homo sapiens	222-226
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	275-279
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	interleukin 4	Homo sapiens	300-303
16009709-3	2005	Here, using chromatin immunoprecipitation and real time reverse transcription PCR we identify the Polycomb family histone methyltransferase EZH2 as the enzyme responsible for methylating lysine 27 of histone H3 at the Il4-Il13 locus of T(H)1 but not T(H)2 cells, implicating EZH2 in the mechanism of Il4 and Il13 transcriptional silencing.	Lysine	187-193	interleukin 13	Homo sapiens	308-312
16135789-4	2005	Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha).	Lysine	22-28	tumor necrosis factor	Mus musculus	149-176
15890677-3	2005	In this report, we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro, and potently stimulates Foxo1-induced transcription of IGF-binding protein-1 in transient transfection experiments.	Lysine	70-77	forkhead box O1	Homo sapiens	113-118
15890677-3	2005	In this report, we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro, and potently stimulates Foxo1-induced transcription of IGF-binding protein-1 in transient transfection experiments.	Lysine	70-77	forkhead box O1	Homo sapiens	165-170
16023247-8	2005	We have found that Loxl2 is able to oxidize lysine residues of collagen, and behaves in that respect similarly to Lox.	Lysine	44-50	lysyl oxidase like 2	Homo sapiens	19-24
16135789-2	2005	Acetylation at lysines 218, 221, and 310 differentially regulates RelA"s DNA binding activity, assembly with IkappaBalpha, and transcriptional activity.	Lysine	15-22	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	109-121
16135789-4	2005	Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha).	Lysine	22-28	tumor necrosis factor	Mus musculus	178-187
16135789-7	2005	Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene.	Lysine	135-141	tumor necrosis factor	Mus musculus	102-111
16109848-3	2005	Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine residue (Lys259) in vivo.	Lysine	130-136	circadian locomotor output cycles kaput	Mus musculus	77-82
15958389-6	2005	HIPK2 with a mutated SUMO acceptor lysine residue was refractory to inhibition of HIPK2-mediated JNK activation by SUMO-1.	Lysine	35-41	mitogen-activated protein kinase 8	Homo sapiens	97-100
16042383-0	2005	Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex.	Lysine	90-96	coagulation factor II, thrombin	Homo sapiens	148-159
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	forkhead box O1	Homo sapiens	28-33
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	forkhead box O1	Homo sapiens	51-55
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	CREB binding protein	Homo sapiens	186-207
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	CREB binding protein	Homo sapiens	209-212
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	forkhead box O1	Homo sapiens	345-350
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	28-33
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	51-55
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	CREB binding protein	Homo sapiens	186-207
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	CREB binding protein	Homo sapiens	209-212
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	345-350
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	28-33
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	51-55
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	CREB binding protein	Homo sapiens	186-207
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	CREB binding protein	Homo sapiens	209-212
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	forkhead box O1	Homo sapiens	345-350
16076959-4	2005	Here, we show that the positive charge of these lysines in Foxo1 contributes to its DNA-binding, and acetylation at these residues by CBP attenuates its ability to bind cognate DNA sequence.	Lysine	48-55	forkhead box O1	Homo sapiens	59-64
16076959-4	2005	Here, we show that the positive charge of these lysines in Foxo1 contributes to its DNA-binding, and acetylation at these residues by CBP attenuates its ability to bind cognate DNA sequence.	Lysine	48-55	CREB binding protein	Homo sapiens	134-137
16094449-7	2005	Another histone methyltransferase, Dot1, methylates lysine 79 of histone H3 and is also essential for proper silencing of genes near telomeres, the rDNA loci, and the mating type loci.	Lysine	52-58	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	35-39
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	112-115	insulin like growth factor 1	Homo sapiens	299-304
15894420-3	2005	When receptor bound, on the other hand, significant differences in the conformational dynamics of the reporter groups were observed with the C-terminal Lys(69) derivative displaying by far the greatest mobility strongly suggesting that the C-terminal domain of the bound neurotoxin is highly mobile and does not participate in the toxin-nAChR binding surface.	Lysine	152-155	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	337-342
15986205-3	2005	Trimethylation of histone H3 on lysine 27, mediated by a PcG protein complex consisting of Eed, Ezh2, and Suz12, is integral in differentiation, stem cell self-renewal, and tumorigenesis.	Lysine	32-38	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	96-100
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	112-115	insulin like growth factor 1	Homo sapiens	410-415
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	131-134	insulin like growth factor 1	Homo sapiens	299-304
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	131-134	insulin like growth factor 1	Homo sapiens	410-415
15997205-11	2005	Alanine scanning mutagenesis of thirteen lysine residues in ASM demonstrated that 93lysine residue plays a critical role in ASM targeting since the K93A mutant had reduced intracellular activity, but enhanced secreted activity that was zinc responsive.	Lysine	41-47	sphingomyelin phosphodiesterase 1	Homo sapiens	60-63
16111893-4	2005	Acetylation of discrete lysine residues in RelA modulates distinct functions of NF-kappaB, including transcriptional activation, DNA binding, and assembly with its inhibitor IkappaBalpha.	Lysine	24-30	nuclear factor kappa B subunit 1	Homo sapiens	80-89
16111893-4	2005	Acetylation of discrete lysine residues in RelA modulates distinct functions of NF-kappaB, including transcriptional activation, DNA binding, and assembly with its inhibitor IkappaBalpha.	Lysine	24-30	NFKB inhibitor alpha	Homo sapiens	174-186
15997205-11	2005	Alanine scanning mutagenesis of thirteen lysine residues in ASM demonstrated that 93lysine residue plays a critical role in ASM targeting since the K93A mutant had reduced intracellular activity, but enhanced secreted activity that was zinc responsive.	Lysine	41-47	sphingomyelin phosphodiesterase 1	Homo sapiens	124-127
15927961-5	2005	Mutagenesis of a conserved, C-terminal lysine residue (197) relocalized the enzyme to the Golgi, demonstrating that Lys-197 is essential for targeting PEMT to the ER.	Lysine	39-45	phosphatidylethanolamine N-methyltransferase	Mus musculus	151-155
15950946-3	2005	A MORi3 peptide with a Lys &gt; Ala substitution--shown to reduce CaM-binding of intact MOR--bound fivefold less avidly than the wild-type peptide.	Lysine	23-26	calmodulin 1	Homo sapiens	66-69
15886205-4	2005	Analysis of the c-FLIP(S)-specific ubiquitylation revealed two lysines, 192 and 195, C-terminal to the death effector domains, as principal ubiquitin acceptors in c-FLIP(S) but not in c-FLIP(L).	Lysine	63-70	CASP8 and FADD like apoptosis regulator	Homo sapiens	163-169
15886205-4	2005	Analysis of the c-FLIP(S)-specific ubiquitylation revealed two lysines, 192 and 195, C-terminal to the death effector domains, as principal ubiquitin acceptors in c-FLIP(S) but not in c-FLIP(L).	Lysine	63-70	CASP8 and FADD like apoptosis regulator	Homo sapiens	163-169
15886205-5	2005	Furthermore the c-FLIP(S)-specific tail of 19 amino acids, adjacent to the two target lysines, was demonstrated to be the key element determining the isoform-specific instability of c-FLIP(S).	Lysine	86-93	CASP8 and FADD like apoptosis regulator	Homo sapiens	16-22
15886205-5	2005	Furthermore the c-FLIP(S)-specific tail of 19 amino acids, adjacent to the two target lysines, was demonstrated to be the key element determining the isoform-specific instability of c-FLIP(S).	Lysine	86-93	CASP8 and FADD like apoptosis regulator	Homo sapiens	182-188
15936721-5	2005	LINCR preferentially interacted with the ubiquitin-conjugating enzyme UbcH6 and preferentially generated polyubiquitin chains linked via non-canonical lysine residues.	Lysine	151-157	neuralized E3 ubiquitin protein ligase 3	Homo sapiens	0-5
15936721-5	2005	LINCR preferentially interacted with the ubiquitin-conjugating enzyme UbcH6 and preferentially generated polyubiquitin chains linked via non-canonical lysine residues.	Lysine	151-157	ubiquitin conjugating enzyme E2 E1	Homo sapiens	70-75
15927961-5	2005	Mutagenesis of a conserved, C-terminal lysine residue (197) relocalized the enzyme to the Golgi, demonstrating that Lys-197 is essential for targeting PEMT to the ER.	Lysine	116-119	phosphatidylethanolamine N-methyltransferase	Mus musculus	151-155
16024656-4	2005	RNAi against hSki8 or hCtr9 reduces the cellular levels of other hPAF subunits and of mono- and trimethylated H3-Lys 4 and dimethylated H3-Lys 79.	Lysine	113-116	CTR9 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	22-27
16039595-3	2005	Previous reports have indicated that ubiquitylation of histone H2B K123 is required for methylation of lysines 4 and 79 of histone H3 by the methyltransferases Set1 and Dot1, respectively.	Lysine	103-110	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	160-164
16039595-3	2005	Previous reports have indicated that ubiquitylation of histone H2B K123 is required for methylation of lysines 4 and 79 of histone H3 by the methyltransferases Set1 and Dot1, respectively.	Lysine	103-110	DOT1 like histone lysine methyltransferase	Homo sapiens	169-173
16024656-4	2005	RNAi against hSki8 or hCtr9 reduces the cellular levels of other hPAF subunits and of mono- and trimethylated H3-Lys 4 and dimethylated H3-Lys 79.	Lysine	139-142	CTR9 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	22-27
15870073-6	2005	Alanine scanning mutagenesis revealed a discrete domain within loop 2 that contributes to GRK2 binding, and the mutation of either lysine 691 or 692 to an alanine within this domain resulted in a loss of GRK2 binding to both mGluR1a and mGluR1b.	Lysine	131-137	G protein-coupled receptor kinase 2	Homo sapiens	204-208
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	104-107	Cd48 molecule	Rattus norvegicus	11-15
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	157-160	Cd48 molecule	Rattus norvegicus	11-15
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	157-160	Cd48 molecule	Rattus norvegicus	223-227
15970672-1	2005	Methylation of histone lysine residues in eukaryotic chromatin has been an exciting area of research ever since the first histone methyltransferase enzyme, Suv39h, was found to methylate lysine 9 of histone H3 in 2000.	Lysine	23-29	SUV39H1 histone lysine methyltransferase	Homo sapiens	156-162
15970672-1	2005	Methylation of histone lysine residues in eukaryotic chromatin has been an exciting area of research ever since the first histone methyltransferase enzyme, Suv39h, was found to methylate lysine 9 of histone H3 in 2000.	Lysine	187-193	SUV39H1 histone lysine methyltransferase	Homo sapiens	156-162
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Lysine	157-163	epidermal growth factor receptor	Homo sapiens	37-41
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Lysine	157-163	epidermal growth factor receptor	Homo sapiens	51-55
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Lysine	157-163	epidermal growth factor receptor	Homo sapiens	119-123
15878871-12	2005	Single mutations at amino acid positions Lys(114), Asp(169), Thr(173), Tyr(175), and Leu(176) affected C1q binding to CRP.	Lysine	41-44	C-reactive protein	Homo sapiens	118-121
15870070-3	2005	Within endothelial cells, but not a variety of nonendothelial cells, the nucleosomes that encompassed the eNOS core promoter and proximal downstream coding regions were highly enriched in acetylated histones H3 and H4 and methylated lysine 4 of histone H3.	Lysine	233-239	nitric oxide synthase 3	Homo sapiens	106-110
15870070-8	2005	H3 lysine 4 methylation was also essential for eNOS expression, since treatment of endothelial cells with methylthioadenosine, a known lysine 4 methylation inhibitor, decreased eNOS RNA levels, H3 lysine 4 methylation, and RNA polymerase II loading at the eNOS proximal promoter.	Lysine	3-9	nitric oxide synthase 3	Homo sapiens	47-51
15870070-8	2005	H3 lysine 4 methylation was also essential for eNOS expression, since treatment of endothelial cells with methylthioadenosine, a known lysine 4 methylation inhibitor, decreased eNOS RNA levels, H3 lysine 4 methylation, and RNA polymerase II loading at the eNOS proximal promoter.	Lysine	135-141	nitric oxide synthase 3	Homo sapiens	47-51
15870073-7	2005	Mutation of either Lys(691) or Lys(692) prevented GRK2-mediated attenuation of mGluR1b signaling, whereas the mutation of only Lys(692) prevented GRK2-mediated inhibition of mGluR1a signaling.	Lysine	19-22	G protein-coupled receptor kinase 2	Homo sapiens	50-54
15870073-7	2005	Mutation of either Lys(691) or Lys(692) prevented GRK2-mediated attenuation of mGluR1b signaling, whereas the mutation of only Lys(692) prevented GRK2-mediated inhibition of mGluR1a signaling.	Lysine	31-34	G protein-coupled receptor kinase 2	Homo sapiens	50-54
15870073-7	2005	Mutation of either Lys(691) or Lys(692) prevented GRK2-mediated attenuation of mGluR1b signaling, whereas the mutation of only Lys(692) prevented GRK2-mediated inhibition of mGluR1a signaling.	Lysine	31-34	G protein-coupled receptor kinase 2	Homo sapiens	50-54
15972682-6	2005	Chromatin immunoprecipitation assay demonstrated that TNF-alpha also induced selective histone H4 acetylation on lysines 5 and 12 at the eotaxin promoter site and p65 binding to the eotaxin promoter, resulting in eotaxin gene transcription.	Lysine	113-120	tumor necrosis factor	Homo sapiens	54-63
15972587-4	2005	DMP1 and BSP, each containing both glutamine and lysine residues critical for crosslink formation, readily formed polymers in vitro when incubated with TG2.	Lysine	49-55	transglutaminase 2	Homo sapiens	152-155
15972682-6	2005	Chromatin immunoprecipitation assay demonstrated that TNF-alpha also induced selective histone H4 acetylation on lysines 5 and 12 at the eotaxin promoter site and p65 binding to the eotaxin promoter, resulting in eotaxin gene transcription.	Lysine	113-120	C-C motif chemokine ligand 11	Homo sapiens	137-144
15817634-5	2005	Critical glutamate, aspartate, lysine, arginine and histidine residues in ILs/ELs and TMs were detected that were essential for kNBC1-mediated Na(+)-dependent base transport.	Lysine	31-37	solute carrier family 4 member 4	Homo sapiens	128-133
15920479-4	2005	Strains lacking Sas2 histone acetylase or the histone methylases that modify lysines 4 (Set1) or 79 (Dot1) of H3 display accelerated Sir3 accumulation at HMR or its spreading away from the telomere, suggesting that these histone modifications exert distinct inhibitory effects on heterochromatin formation.	Lysine	77-84	histone acetyltransferase	Saccharomyces cerevisiae S288C	16-20
15953362-4	2005	Employing both in vitro and in vivo approaches, tau was found to be a substrate of the TRAF6, possessing lysine 63 polyubiquitin chains.	Lysine	105-111	TNF receptor-associated factor 6	Mus musculus	87-92
15824120-10	2005	Ataxin-1 SUMOylation was mapped to at least five lysine residues.	Lysine	49-55	ataxin 1	Homo sapiens	0-8
15817459-9	2005	We further unveiled that the methylation status of Lys-27 but not Lys-9 of H3 in hDAB2IP promoter region is consistent with the hDAB2IP levels in both normal prostatic epithelial cells and PCa cells.	Lysine	51-54	DAB2 interacting protein	Homo sapiens	81-88
15817459-9	2005	We further unveiled that the methylation status of Lys-27 but not Lys-9 of H3 in hDAB2IP promoter region is consistent with the hDAB2IP levels in both normal prostatic epithelial cells and PCa cells.	Lysine	51-54	DAB2 interacting protein	Homo sapiens	128-135
15941828-4	2005	Like Set1, MLL1 localizes with RNA polymerase II (Pol II) to the 5" end of actively transcribed genes, where histone H3 lysine 4 trimethylation occurs.	Lysine	120-126	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	5-9
15824120-11	2005	Lys(16), Lys(194) preceding the polyglutamine tract, Lys(610)/Lys(697) in the C-terminal ataxin high mobility group domain, and Lys(746) all contribute to ataxin-1 SUMOylation.	Lysine	0-3	ataxin 1	Homo sapiens	155-163
15831498-2	2005	We have recently demonstrated that the inhibitory Smad7 interacts with the acetyl transferase p300 and that p300 acetylates Smad7 on two lysine residues.	Lysine	137-143	SMAD family member 7	Homo sapiens	50-55
16037261-5	2005	Tandem mass spectrometric analysis demonstrated that lysine residues were the only amino acids in apoA-I that were modified by acrolein.	Lysine	53-59	apolipoprotein A1	Homo sapiens	98-104
15831498-2	2005	We have recently demonstrated that the inhibitory Smad7 interacts with the acetyl transferase p300 and that p300 acetylates Smad7 on two lysine residues.	Lysine	137-143	SMAD family member 7	Homo sapiens	124-129
15831498-3	2005	These lysine residues are critical for Smurf-mediated ubiquitination of Smad7, and acetylation protects Smad7 from TGFbeta-induced degradation.	Lysine	6-12	SMAD family member 7	Homo sapiens	72-77
15850772-9	2005	Collectively, these findings demonstrate that inactivation of MAPK, Akt, and activation of the JNK pathway contributes to the induction of apoptosis induced by fludarabine/LY.	Lysine	172-174	AKT serine/threonine kinase 1	Homo sapiens	68-71
15850772-9	2005	Collectively, these findings demonstrate that inactivation of MAPK, Akt, and activation of the JNK pathway contributes to the induction of apoptosis induced by fludarabine/LY.	Lysine	172-174	mitogen-activated protein kinase 8	Homo sapiens	95-98
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Lysine	127-133	histidine triad nucleotide binding protein 1	Homo sapiens	93-97
15890278-3	2005	Using data from c-AMP assays in combination with structural analysis of melanocortin receptor/ligand models, we conclude that a lysine residue at the C-terminus of the His-Phe-Arg-Trp core sequence of melanocortin hormone is an important determinant for receptor selectivity in the both cyclic and linear MSH analogues.	Lysine	128-134	msh homeobox 2	Homo sapiens	305-308
16021577-4	2005	The deletion leads to the replacement of a valine and a lysine by a glutamate in the BRAF activation segment (BRAF(VK600-1E)), thus mimicking partially the 2 BRAF mutations previously described.	Lysine	56-62	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	85-89
16021577-4	2005	The deletion leads to the replacement of a valine and a lysine by a glutamate in the BRAF activation segment (BRAF(VK600-1E)), thus mimicking partially the 2 BRAF mutations previously described.	Lysine	56-62	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
16021577-4	2005	The deletion leads to the replacement of a valine and a lysine by a glutamate in the BRAF activation segment (BRAF(VK600-1E)), thus mimicking partially the 2 BRAF mutations previously described.	Lysine	56-62	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
15910735-0	2005	Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1.	Lysine	12-18	LDL receptor related protein 1	Homo sapiens	88-138
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	45-48	LDL receptor related protein 1	Homo sapiens	101-151
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	45-48	LDL receptor related protein 1	Homo sapiens	153-158
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	59-62	LDL receptor related protein 1	Homo sapiens	101-151
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	59-62	LDL receptor related protein 1	Homo sapiens	153-158
15908806-2	2005	Some individuals possess a nonsynonymous variant in the ABCG2 gene at nucleotide 421, substituting lysine for glutamine on position 141 at exon 5.	Lysine	99-105	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	56-61
15907489-0	2005	Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.	Lysine	10-16	transforming growth factor beta 1	Homo sapiens	56-87
15985705-4	2005	DNQX (10 microM), an AMPA/kainate receptor antagonist, partly attenuated the toxic effects of QA, whereas LY 367 385 (100 microM), a selective mGluR1a antagonist, completely reversed the above effect.	Lysine	106-108	glutamate metabotropic receptor 1	Rattus norvegicus	143-149
15895993-5	2005	Analysis of the NMR structure of the PITX2 homeodomain indicates that the lysine at position 50 makes contacts with two guanines on the antisense strand of the DNA, adjacent to the TAAT core DNA sequence, consistent with the structure of EnQ50K.	Lysine	74-80	paired like homeodomain 2	Homo sapiens	37-42
15907489-9	2005	Thus, the lysine residues of Smad3 MH2 domain play important roles in the transcriptional regulation of TGF-beta signals through TbetaR-I.	Lysine	10-16	transforming growth factor beta 1	Homo sapiens	104-112
15898716-3	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	27-35
15755742-5	2005	Specifically, we find that XendoU residues Glu-161, Glu-167, His-162, His-178, and Lys-224 are essential for RNA cleavage, which occurs in the presence of manganese ions.	Lysine	83-86	endonuclease, poly(U) specific like L homeolog	Xenopus laevis	27-33
15826653-7	2005	Rather, the lysine substitutions alter the delicate balance between the ORF1 protein"s melting and reannealing activities, thereby reducing its nucleic acid chaperone activity.	Lysine	12-18	ORF1	Homo sapiens	72-76
15588254-2	2005	Fatty acid-free or -bound HSA was modified with lysine-specific cross-linkers and digested with trypsin.	Lysine	48-54	albumin	Homo sapiens	26-29
15588254-5	2005	Our data also indicated that the side chains of Lys-205 (IIA) and Lys-466 (IIIA) moved closer towards each other upon binding AA or DHA, but not OA, suggesting that the conformations of HSA when bound to mono- and poly-unsaturated fatty acids are distinctively different.	Lysine	48-51	albumin	Homo sapiens	186-189
15588254-5	2005	Our data also indicated that the side chains of Lys-205 (IIA) and Lys-466 (IIIA) moved closer towards each other upon binding AA or DHA, but not OA, suggesting that the conformations of HSA when bound to mono- and poly-unsaturated fatty acids are distinctively different.	Lysine	66-69	albumin	Homo sapiens	186-189
15898716-3	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	49-57
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	Sp3 transcription factor	Homo sapiens	44-47
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	Sp3 transcription factor	Homo sapiens	71-74
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	Sp3 transcription factor	Homo sapiens	71-74
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	Sp3 transcription factor	Homo sapiens	71-74
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	Sp3 transcription factor	Homo sapiens	44-47
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	Sp3 transcription factor	Homo sapiens	71-74
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	Sp3 transcription factor	Homo sapiens	71-74
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	Sp3 transcription factor	Homo sapiens	71-74
15898716-3	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	49-57
15898717-4	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	27-35
15898717-4	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	49-57
15898717-4	2005	This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a).	Lysine	139-145	interferon alpha 1	Homo sapiens	49-57
15845458-3	2005	To address this hypothesis, based upon our quantitative structure-activity relationship data, a total of 107 potential xenobiotic mimics were coupled to the lysine residue of the immunodominant 15 amino acid peptide of the PDC-E2 inner lipoyl domain and spotted on microarray slides.	Lysine	157-163	dihydrolipoamide S-acetyltransferase	Homo sapiens	223-229
15820770-2	2005	There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: GAT--&gt;GAG substitution replaces aspartic acid by glutamic acid in codon 416; and ACG--&gt;AAG substitution in codon 420 leads to an exchange of threonine for lysine.	Lysine	256-262	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
15772853-1	2005	Length variation in the human mtDNA intergenic region between the cytochrome oxidase II (COII) and tRNA lysine (tRNA(lys)) genes has been widely studied in world populations.	Lysine	104-110	mitochondrially encoded tRNA glycine	Homo sapiens	112-121
15831463-6	2005	Mutation of these lysines affects MEF2 DNA binding and transcriptional activity, as well as its synergistic effect with myogenin in myogenic conversion assays.	Lysine	18-25	myocyte enhancer factor 2C	Mus musculus	34-38
15817227-4	2005	Transcriptional desilencing in these rha-1(tm329) mutants was associated with a loss of lysine 9 methylation on histone H3 that is normally associated with silenced chromatin.	Lysine	88-94	ATP-dependent RNA helicase A;RNA helicase	Caenorhabditis elegans	37-42
15713663-12	2005	Chromatin immunoprecipitation assay demonstrated that cyclin D1 enhanced recruitment of HDAC1 and HDAC3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H3 and histone H3 lysine 9.	Lysine	267-273	peroxisome proliferator activated receptor alpha	Mus musculus	149-153
15902492-5	2005	We also demonstrated that replacement of specific lysine residues in histones H3 and H4 by arginine affected the complementation capacity of both the yeast gene (yELP3) and the chimeric yhELP3 in the elp3Deltastrain.	Lysine	50-56	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	162-167
15902492-6	2005	Specifically, mutation of lysine-14 of H3 (H3 K14R) or lysine-8 of H4 (H4 K8R) reduced the ability of yELP3 and yhELP3 to complement the elp3Delta mutant, whereas simultaneous mutation of both sites (H3 K14R/H4 K8R) almost completely abolished complementation.	Lysine	26-32	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	102-107
15902492-6	2005	Specifically, mutation of lysine-14 of H3 (H3 K14R) or lysine-8 of H4 (H4 K8R) reduced the ability of yELP3 and yhELP3 to complement the elp3Delta mutant, whereas simultaneous mutation of both sites (H3 K14R/H4 K8R) almost completely abolished complementation.	Lysine	55-61	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	102-107
15853904-2	2005	HLA-A*6824 differs from A*680102 by a single nucleotide change at position 275 in exon 2, which results in a conservative amino acid substitution from lysine to arginine in the peptide-binding groove at codon 68.	Lysine	151-157	major histocompatibility complex, class I, A	Homo sapiens	0-5
15835896-8	2005	When radiolabeled FGF-1 with mutated NLS1 or the first lysine cluster of NLS2 was added to NIH/3T3 cells, it was translocated into the cytosol, but not transported efficiently to the nucleus.	Lysine	55-61	fibroblast growth factor 1	Mus musculus	18-23
15837927-4	2005	We found that Abeta(21-30) folds into a loop-like conformation driven by an effective hydrophobic attraction between Val-24 and the butyl portion of the Lys-28 side chain.	Lysine	153-156	amyloid beta precursor protein	Homo sapiens	14-19
15823605-9	2005	Substitution of the aspartic acid at position 61 and glutamic acid at position 63 in the SIV(cpz) ANT Vpu within with lysine residues abolished the ability of this protein to down-modulate cell surface expression of CD4.	Lysine	118-124	CD4 molecule	Homo sapiens	216-219
15780627-1	2005	Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative alpha-N-Boc-Lys-CH(2)-CH(2)-dansyl into the protein substrate N,N-dimethylated-casein.	Lysine	241-244	transglutaminase 2	Homo sapiens	106-113
15699045-7	2005	We now report that lysines at positions 11 and 12 in beta-arrestin2 are specific and required sites for its AngII-mediated sustained ubiquitination.	Lysine	19-26	arrestin beta 2	Homo sapiens	53-67
15699045-14	2005	In contrast, a quintuple lysine mutant (beta-arrestin2(K18R,K107R,K108R,K207R,K296R)) is impaired in endosomal trafficking in response to V2R but not AT1aR stimulation.	Lysine	25-31	arrestin beta 2	Homo sapiens	40-54
15699045-15	2005	Our findings delineate a novel regulatory mechanism for 7TMR signaling, dictated by the ubiquitination of beta-arrestin on specific lysines that become accessible for modification due to the specific receptor-bound conformational states of beta-arrestin2.	Lysine	132-139	arrestin beta 2	Homo sapiens	240-254
15851025-3	2005	The yeast Dot1 and its human counterpart, hDOT1L, methylate lysine 79 located within the globular domain of histone H3.	Lysine	60-66	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	10-14
15851025-3	2005	The yeast Dot1 and its human counterpart, hDOT1L, methylate lysine 79 located within the globular domain of histone H3.	Lysine	60-66	DOT1 like histone lysine methyltransferase	Homo sapiens	42-48
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	mitogen-activated protein kinase 3	Homo sapiens	196-200
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	mitogen-activated protein kinase kinase 7	Homo sapiens	202-205
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	mitogen-activated protein kinase 3	Homo sapiens	210-216
15780627-1	2005	Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative alpha-N-Boc-Lys-CH(2)-CH(2)-dansyl into the protein substrate N,N-dimethylated-casein.	Lysine	241-244	transglutaminase 2	Homo sapiens	115-138
15846102-1	2005	We have previously shown that the HDAC inhibitors (HDACI) activate the p53 molecule through acetylation of 320 and 373 lysine residues, upregulate PIG3 and NOXA and induce apoptosis in cancer cells expressing wild and pseudo-wild type p53 genes (Terui T, et al.	Lysine	119-125	tumor protein p53	Homo sapiens	71-74
15899702-3	2005	Cathepsin L, cathepsin K, plasmin, trypsin and tryptase were able to release elafin by cleaving the Lys 38 -Ala 39 peptide bond in trappin-2.	Lysine	100-103	cathepsin L	Homo sapiens	0-11
16705796-4	2005	ARD-1, the acetyltransferase, acetylates HIF-1a at lysine 532, which enhances the interaction of HIF-1a with pVHL.	Lysine	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-47
16705796-4	2005	ARD-1, the acetyltransferase, acetylates HIF-1a at lysine 532, which enhances the interaction of HIF-1a with pVHL.	Lysine	51-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-103
15767411-7	2005	Surprisingly, although the cytosolic tail of class I is required for rapid mK3-mediated degradation, we observed that a class I mutant lacking lysine residues in its cytosolic tail was ubiquitinated and degraded in the presence of mK3 in a manner indistinguishable from wild-type class I molecules.	Lysine	143-149	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	75-78
15677454-5	2005	We found that Tal1/SCL could complex with the histone H3 lysine 9 (H3K9)-specific methyltransferase Suv39H1.	Lysine	57-63	SUV39H1 histone lysine methyltransferase	Homo sapiens	100-107
15729708-4	2005	Activation of the DOTA molecule, resulting in 1,4,7,10-tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid mono-(N-hydroxysuccinimidyl) ester (DOTA-NHS), allows conjugation with the anti-PSMA antibody through lysine residues in the antibody.	Lysine	210-216	folate hydrolase 1	Homo sapiens	188-192
15876410-1	2005	We have tested the effects of two Eli-Lilly compounds, LY 117, 018 and raloxifene, on E2-regulated and IGF-I-induced proliferation or AP-1 activity in human breast cancer cells.	Lysine	55-57	insulin like growth factor 1	Homo sapiens	103-108
15767411-7	2005	Surprisingly, although the cytosolic tail of class I is required for rapid mK3-mediated degradation, we observed that a class I mutant lacking lysine residues in its cytosolic tail was ubiquitinated and degraded in the presence of mK3 in a manner indistinguishable from wild-type class I molecules.	Lysine	143-149	mitogen-activated protein kinase-activated protein kinase 3	Mus musculus	231-234
15769141-3	2005	The rate of lactosylation could be described by an acid dissociation curve corresponding to pK(a) of the epsilon-amino group of lysine in alpha-lactalbumin.	Lysine	128-134	lactalbumin alpha	Homo sapiens	138-155
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	Lysine	186-190	kininogen 1	Homo sapiens	26-28
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	Lysine	186-190	interleukin 1 beta	Homo sapiens	36-44
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	Lysine	186-190	tumor necrosis factor	Homo sapiens	49-57
15664665-4	2005	The stimulatory effect of BK on the IL-1beta- or TNFalpha-stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys-(des-arg9, Leu8)-BK had no effect.	Lysine	186-190	bradykinin receptor B1	Homo sapiens	163-174
15649887-4	2005	A major site of Stat3 that is acetylated by its coactivator, p300/CREB-binding protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.	Lysine	157-163	signal transducer and activator of transcription 3	Homo sapiens	16-21
15649887-4	2005	A major site of Stat3 that is acetylated by its coactivator, p300/CREB-binding protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.	Lysine	157-163	CREB binding protein	Homo sapiens	66-86
15649887-4	2005	A major site of Stat3 that is acetylated by its coactivator, p300/CREB-binding protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.	Lysine	157-163	CREB binding protein	Homo sapiens	88-91
15769141-5	2005	Second-order rate constants for protonated and unprotonated lysine in alpha-lactalbumin both showed Arrhenius behavior, and using transition-state theory, DeltaH# = 31 +/- 2 kJ/mol and DeltaS# = -266 +/- 48 J/(mol .	Lysine	60-66	lactalbumin alpha	Homo sapiens	70-87
15590655-4	2005	An additional step, the disruption of an electrostatic bond formed between Asp-33 (halpha1) and Lys-64 (BH3), allows the mitochondria addressing of Bax.	Lysine	96-99	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151
15769141-8	2005	On the basis of the marked differences in activation parameters, initial formation of a lactosylamine is suggested as rate-determining for reaction between lactose and a protonated lysine in alpha-lactalbumin, while subsequent water elimination to form a Schiff base becomes rate-determining for the unprotonated form.	Lysine	181-187	lactalbumin alpha	Homo sapiens	191-208
15744310-5	2005	We find that once SIRT1 is induced, it interacts with and deacetylates PGC-1alpha at specific lysine residues in an NAD(+)-dependent manner.	Lysine	94-100	PPARG coactivator 1 alpha	Homo sapiens	71-81
15743186-3	2005	On the basis of these findings, we combined in the N/OFQ-NH(2) template the chemical modifications Arg(14)-Lys(15) and (pF)Phe(4) that increase the agonist potency with those conferring partial agonist (Phe(1)Psi(CH(2)NH)Gly(2)) or pure antagonist (Nphe(1)) properties.	Lysine	107-110	prepronociceptin	Homo sapiens	51-56
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	37-40	CORD1	Homo sapiens	24-28
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	50-53	CORD1	Homo sapiens	24-28
15745743-1	2005	Tissue transglutaminase (TGase) is a Ca(2+)-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues.	Lysine	192-195	transglutaminase 2	Homo sapiens	0-23
15542598-6	2005	We found that thrombin proteolyzed tau at multiple arginine and lysine sites.	Lysine	64-70	coagulation factor II, thrombin	Homo sapiens	14-22
15723520-5	2005	The 21 lysine residues within apoA-I were treated with homo bifunctional chemical cross-linkers capable of covalently bridging two lysine residues residing within a defined spacer arm length.	Lysine	7-13	apolipoprotein A1	Homo sapiens	30-36
15723520-5	2005	The 21 lysine residues within apoA-I were treated with homo bifunctional chemical cross-linkers capable of covalently bridging two lysine residues residing within a defined spacer arm length.	Lysine	131-137	apolipoprotein A1	Homo sapiens	30-36
15713636-3	2005	In this study, we show that an intergenic cis-acting element in the mouse lambda5-VpreB1 locus is marked by histone H3 acetylation and histone H3 lysine 4 methylation at a discrete site in embryonic stem (ES) cells.	Lysine	146-152	pre-B lymphocyte gene 2	Mus musculus	74-81
15723520-8	2005	Using the cross-linker spacer arm length as a constraint for identified Lys pairs, a molecular model was built for the lipid-free apoA-I monomer based on homology with proteins of similar sequence and known three-dimensional structures.	Lysine	72-75	apolipoprotein A1	Homo sapiens	130-136
15881673-10	2005	Mutation of two lysine residues greatly reduced the amount of the sumoylated form of OZF though their surrounding sequences differ from the consensus sequence reported for most proteins modified by SUMO-1 conjugation.	Lysine	16-22	zinc finger protein 146	Homo sapiens	85-88
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Lysine	161-164	parathyroid hormone	Rattus norvegicus	15-34
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Lysine	161-164	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	130-135
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Lysine	165-168	parathyroid hormone	Rattus norvegicus	15-34
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Lysine	165-168	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	130-135
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Lysine	2-5	cytochrome c, somatic	Homo sapiens	43-55
15709747-2	2005	A Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the Red substructure of cytochrome c through the pH and guanidine hydrochloride (gdnHCl) dependence of the His 73-mediated alkaline conformational transition.	Lysine	2-5	cytochrome c, somatic	Homo sapiens	145-157
15748688-3	2005	The 67 amino acid carboxyl-terminal domain (P67) of human propionyl-CoA carboxylase alpha subunit can be metabolically biotinylated at a fixed lysine residue.	Lysine	143-149	CD33 molecule	Homo sapiens	44-47
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	Lysine	142-144	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
15837518-8	2005	Finally, the transglutaminase, Factor XIIIa, covalently binds specific glutamine residues in one fibrin molecule to lysine residues in another via isopeptide bonds, stabilizing the clot against mechanical, chemical, and proteolytic insults.	Lysine	116-122	coagulation factor XIII A chain	Homo sapiens	31-43
15494207-6	2005	Substitution of arginine for lysine at one putative site of sumoylation, lysine(551), blocked sumoylation of all Sp3 isoforms in vivo and led to a marginal increase in Sp3-mediated trans-activation in insect and mammalian cells.	Lysine	29-35	Sp3 transcription factor	Homo sapiens	113-116
15494207-6	2005	Substitution of arginine for lysine at one putative site of sumoylation, lysine(551), blocked sumoylation of all Sp3 isoforms in vivo and led to a marginal increase in Sp3-mediated trans-activation in insect and mammalian cells.	Lysine	29-35	Sp3 transcription factor	Homo sapiens	168-171
15494207-6	2005	Substitution of arginine for lysine at one putative site of sumoylation, lysine(551), blocked sumoylation of all Sp3 isoforms in vivo and led to a marginal increase in Sp3-mediated trans-activation in insect and mammalian cells.	Lysine	73-79	Sp3 transcription factor	Homo sapiens	113-116
15531760-8	2005	Finally the purified recombinant SCF(MAFbx) complex (SCF, Skp1, Cdc53/Cullin 1, F-box protein) mediated MyoD ubiquitination in vitro in a lysine-dependent pathway.	Lysine	138-144	myogenic differentiation 1	Homo sapiens	104-108
15531760-9	2005	Mutation of the lysine 133 in MyoD prevented its ubiquitination by the recombinant SCF(MAFbx) complex.	Lysine	16-22	myogenic differentiation 1	Homo sapiens	30-34
15701846-2	2005	Recently, a polymorphic variant in the EGFR gene that leads to an arginine-to-lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified.	Lysine	78-84	epidermal growth factor receptor	Homo sapiens	39-43
15701846-2	2005	Recently, a polymorphic variant in the EGFR gene that leads to an arginine-to-lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified.	Lysine	78-84	epidermal growth factor receptor	Homo sapiens	162-166
15653507-0	2005	Stat3 dimerization regulated by reversible acetylation of a single lysine residue.	Lysine	67-73	signal transducer and activator of transcription 3	Homo sapiens	0-5
15653507-2	2005	We show that in response to cytokine treatment, Stat3 is also acetylated on a single lysine residue, Lys685.	Lysine	85-91	signal transducer and activator of transcription 3	Homo sapiens	48-53
15567154-3	2005	When the A6-d-ANase gene was expressed in the Escherichia coli dnaK mutant dnaK756, little activity was observed in the soluble fraction, and it was restored by the coexpression of DnaKJE or the substitution of the R354 residue of A6-d-ANase for lysine.	Lysine	246-252	molecular chaperone DnaK	Achromobacter xylosoxidans	63-67
15629688-11	2005	In a second study, apoE was detectable in plasma of five mice treated with alginate poly-l-lysine beads, 4 and 7 days post-implantation, though not at day 14.	Lysine	84-97	apolipoprotein E	Mus musculus	19-23
15677493-4	2005	In this study, we determined in vivo the insulin receptor signaling characteristics activated by insulin glulisine (Lys(B3), Glu(B29)) at the level of insulin receptor phosphorylation, insulin receptor substrate phosphorylation, and downstream signaling elements such as phosphatidylinositol (PI) 3-kinase, AKT, and mitogen-activated protein kinase.	Lysine	116-119	insulin	Homo sapiens	41-48
15677493-4	2005	In this study, we determined in vivo the insulin receptor signaling characteristics activated by insulin glulisine (Lys(B3), Glu(B29)) at the level of insulin receptor phosphorylation, insulin receptor substrate phosphorylation, and downstream signaling elements such as phosphatidylinositol (PI) 3-kinase, AKT, and mitogen-activated protein kinase.	Lysine	116-119	insulin	Homo sapiens	97-104
15677493-4	2005	In this study, we determined in vivo the insulin receptor signaling characteristics activated by insulin glulisine (Lys(B3), Glu(B29)) at the level of insulin receptor phosphorylation, insulin receptor substrate phosphorylation, and downstream signaling elements such as phosphatidylinositol (PI) 3-kinase, AKT, and mitogen-activated protein kinase.	Lysine	116-119	insulin	Homo sapiens	97-104
15677493-4	2005	In this study, we determined in vivo the insulin receptor signaling characteristics activated by insulin glulisine (Lys(B3), Glu(B29)) at the level of insulin receptor phosphorylation, insulin receptor substrate phosphorylation, and downstream signaling elements such as phosphatidylinositol (PI) 3-kinase, AKT, and mitogen-activated protein kinase.	Lysine	116-119	insulin	Homo sapiens	97-104
15712295-5	2005	However, long preincubation with antiestrogens LY(156,758) and ICI(164,384) decreased MeHg-induced foci formation, Ca(2+) mobilization, and Erk1/2 activation, confirming involvement of ERs.	Lysine	47-49	mitogen-activated protein kinase 3	Homo sapiens	140-146
15634919-3	2005	In this study, we have assessed the influence of a conserved lysine at position 408, which lies in the tapasin transmembrane/cytoplasmic domain.	Lysine	61-67	TAP binding protein	Homo sapiens	103-110
15634919-5	2005	In addition to affecting TAP interaction with tapasin, the substitution of alanine, but not tryptophan, for the lysine at tapasin position 408 increased the amount of tapasin found in association with the open, peptide-free form of the HLA-B8 H chain.	Lysine	112-118	TAP binding protein	Homo sapiens	122-129
15634919-5	2005	In addition to affecting TAP interaction with tapasin, the substitution of alanine, but not tryptophan, for the lysine at tapasin position 408 increased the amount of tapasin found in association with the open, peptide-free form of the HLA-B8 H chain.	Lysine	112-118	TAP binding protein	Homo sapiens	122-129
15516695-9	2005	On the other hand, Lys(149) is close to a cluster of acidic amino acids near the FMN binding site of CPR.	Lysine	19-22	cytochrome p450 oxidoreductase	Homo sapiens	101-104
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	6-9	cytochrome p450 oxidoreductase	Homo sapiens	52-55
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	6-9	cytochrome p450 oxidoreductase	Homo sapiens	144-147
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	19-22	cytochrome p450 oxidoreductase	Homo sapiens	52-55
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	19-22	cytochrome p450 oxidoreductase	Homo sapiens	144-147
15869391-4	2005	This review describes structural aspects of methylation of histone lysine residues by two enzyme families with entirely different structural scaffolding (the SET proteins and Dot1p) and methylation of protein arginine residues by PRMTs.	Lysine	67-73	DOT1 like histone lysine methyltransferase	Homo sapiens	175-180
15651848-4	2005	GSBQ formed adducts with cytochrome c at pH 6 on several histidine and lysine residues.	Lysine	71-77	cytochrome c, somatic	Homo sapiens	25-37
15656571-2	2005	It can efficiently react with the lysine residues of recombinant human serum albumin (rHSA), giving a new albumin-heme conjugate [rHSA(FeP-Glu)].	Lysine	34-40	albumin	Homo sapiens	71-84
15608118-7	2005	However, small but significant differences are observed; in contrast to the minor groove recognition of TRF1, in which an arginine residue recognizes the TT sequence, a lysine residue of TRF2 interacts with the TT part.	Lysine	169-175	telomeric repeat binding factor 1	Homo sapiens	104-108
15371351-1	2005	We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine (K)79 residue of histone H3.	Lysine	172-178	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	120-124
15371366-7	2005	The DOT1 gene is of interest because its only known function is to methylate one lysine residue in the core of the histone H3 protein.	Lysine	81-87	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	4-8
15703453-4	2005	The lysine (K) at position 71 as in DRB1*0406 has been reported to be associated with rheumatoid arthritis (RA) and insulin dependent diabetes mellitus (IDDM).	Lysine	4-10	major histocompatibility complex, class II, DR beta 1	Homo sapiens	36-40
15715085-2	2005	Our laboratory previously demonstrated that huntingtin protein colocalizes with transglutaminase 2 and its product, the epsilon-(gamma-glutamyl)lysine bond in intranuclear inclusions in HD frontal cortex.	Lysine	144-150	transglutaminase 2	Homo sapiens	80-98
15574370-8	2005	The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of tPA-dependent plasmin production.	Lysine	22-29	S100 calcium binding protein A10	Homo sapiens	33-40
15574370-9	2005	Carboxypeptidases cleave the carboxyl-terminal lysines of S100A10, resulting in a loss of binding and activity.	Lysine	47-54	S100 calcium binding protein A10	Homo sapiens	58-65
15630020-4	2005	His2Av mutants show reduced acetylation of histone H4 at Lys 12, decreased methylation of histone H3 at Lys 9, and a reduction in HP1 recruitment to the centromeric region.	Lysine	57-60	Histone H2A variant	Drosophila melanogaster	0-6
15630020-4	2005	His2Av mutants show reduced acetylation of histone H4 at Lys 12, decreased methylation of histone H3 at Lys 9, and a reduction in HP1 recruitment to the centromeric region.	Lysine	104-107	Histone H2A variant	Drosophila melanogaster	0-6
15630020-6	2005	The results suggest an ordered cascade of events leading to the establishment of heterochromatin and requiring the recruitment of the histone H2Av variant followed by H4 Lys 12 acetylation as necessary steps before H3 Lys 9 methylation and HP1 recruitment can take place.	Lysine	170-173	Histone H2A variant	Drosophila melanogaster	134-146
15630020-6	2005	The results suggest an ordered cascade of events leading to the establishment of heterochromatin and requiring the recruitment of the histone H2Av variant followed by H4 Lys 12 acetylation as necessary steps before H3 Lys 9 methylation and HP1 recruitment can take place.	Lysine	170-173	Suppressor of variegation 205	Drosophila melanogaster	240-243
15630020-6	2005	The results suggest an ordered cascade of events leading to the establishment of heterochromatin and requiring the recruitment of the histone H2Av variant followed by H4 Lys 12 acetylation as necessary steps before H3 Lys 9 methylation and HP1 recruitment can take place.	Lysine	218-221	Histone H2A variant	Drosophila melanogaster	134-146
15921168-4	2005	Direct DNA sequence analysis of selectively amplified segments of the alpha1 and alpha2 genes showed that codon 7 of the alpha2-globin gene was heterozygous for AAG (Lys) and GAG (Glu).	Lysine	166-169	glycoprotein hormone subunit alpha 2	Homo sapiens	81-87
15613337-4	2005	Sequence analysis of the F1L open reading frame revealed a C-terminal motif composed of a 12-amino-acid transmembrane domain flanked by positively charged lysines, followed by an 8-amino-acid hydrophilic tail.	Lysine	155-162	Hypothetical protein	Vaccinia virus	25-28
15613337-6	2005	In addition, mutation of lysines 219 and 222 downstream of the C-terminal transmembrane domain resulted in altered localization of F1L to the endoplasmic reticulum.	Lysine	25-32	Hypothetical protein	Vaccinia virus	131-134
15466860-7	2004	Polyubiquitylation of FEZ1 by E4B required Lys(27) of ubiquitin.	Lysine	43-46	fasciculation and elongation protein zeta 1	Homo sapiens	22-26
15650327-0	2004	Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.	Lysine	60-66	4-aminobutyrate aminotransferase	Homo sapiens	41-58
16181986-10	2005	CONCLUSIONS: Acetylation of lysine residues in the fibrinogen molecule may explain the alterations in its clotting property, resulting in altered fibrin gel permeability.	Lysine	28-34	fibrinogen beta chain	Homo sapiens	51-61
15596546-2	2004	In Drosophila, PRC2 methylates histone H3 on lysine 27, and this epigenetic mark facilitates recruitment of PRC1.	Lysine	45-51	fascetto	Drosophila melanogaster	108-112
15633743-3	2004	The PEGylation sites of all isomers of PEG-GRF (1-29) conjugates were identified by determining the molecular masses of the Lys-C digested fragments with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Lysine	124-127	growth hormone releasing hormone	Homo sapiens	43-46
15456790-5	2004	Ala substitution of Glu-248 and Lys-251 as well as of Lys-324, Lys-342, Lys-420, and Phe-421 severely decreased or abolished CYP2E1 recognition by the majority of both the halothane hepatitis and alcoholic liver disease sera, whereas the other substitutions had only minor effects.	Lysine	32-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	125-131
15623605-2	2004	EXPERIMENTAL DESIGN: Using the phage display technique, we created a lysine-deficient mutant TNF-alpha (mTNF-K90R).	Lysine	69-75	tumor necrosis factor	Homo sapiens	93-102
15518912-2	2004	We previously reported that the replacement of Lys by Arg, and Met by Leu in VIP (IK312532; [Arg15, 20, 21, Leu17]-VIP) resulted in a significant improvement in metabolic stability and biological activity.	Lysine	47-50	vasoactive intestinal peptide	Rattus norvegicus	77-80
15518912-2	2004	We previously reported that the replacement of Lys by Arg, and Met by Leu in VIP (IK312532; [Arg15, 20, 21, Leu17]-VIP) resulted in a significant improvement in metabolic stability and biological activity.	Lysine	47-50	vasoactive intestinal peptide	Rattus norvegicus	115-118
15568807-0	2004	High-resolution X-ray structure of the unexpectedly stable dimer of the [Lys(-2)-Arg(-1)-des(17-21)]endothelin-1 peptide.	Lysine	73-76	endothelin 1	Homo sapiens	100-112
15351781-4	2004	In a model of the rhodopsin-arrestin complex, the phosphates point in the direction of arrestin and form a continuous negatively charged surface, which is stabilized by a number of positively charged lysine and arginine residues of arrestin.	Lysine	200-206	rhodopsin	Homo sapiens	18-27
15456790-5	2004	Ala substitution of Glu-248 and Lys-251 as well as of Lys-324, Lys-342, Lys-420, and Phe-421 severely decreased or abolished CYP2E1 recognition by the majority of both the halothane hepatitis and alcoholic liver disease sera, whereas the other substitutions had only minor effects.	Lysine	54-57	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	125-131
15456790-5	2004	Ala substitution of Glu-248 and Lys-251 as well as of Lys-324, Lys-342, Lys-420, and Phe-421 severely decreased or abolished CYP2E1 recognition by the majority of both the halothane hepatitis and alcoholic liver disease sera, whereas the other substitutions had only minor effects.	Lysine	54-57	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	125-131
15506960-4	2004	For example, the 11-cis retinal chromophore of rhodopsin forms a protonated Schiff base linkage to a lysine in TM7, deep within the helical bundle, and small ligands, such as amine neurotransmitters and non-peptide analogues of peptide hormones, also bind within the corresponding region of their cognate receptors.	Lysine	101-107	rhodopsin	Homo sapiens	47-56
15574338-6	2004	Our results underscore the importance of N-acetylation in restricting N-ubiquitylation and show, in particular, that ubiquitylation of endogenous p21 either at internal lysines or on the N terminus is unlikely to control its degradation by the proteasome.	Lysine	169-176	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-149
15506920-3	2004	We have determined the X-ray crystal structure of a Sir2 homologue from yeast Hst2 (yHst2), in various liganded forms, including the yHst2/acetyl-Lys-16 histone H4/NAD(+) ternary complex; we have also performed related biochemical studies to address the conserved mode of catalysis by these enzymes as well as the distinguishing features that allow different members of the family to target their respective cognate substrates.	Lysine	146-149	histone deacetylase HST2	Saccharomyces cerevisiae S288C	78-82
15558739-2	2004	Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the lysine residue, including acylation of fatty acids or xenobiotics and ubiquitinylation.	Lysine	161-167	dihydrolipoamide S-acetyltransferase	Homo sapiens	23-29
20368827-8	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Lysine	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
15558739-3	2004	More importantly, the immunogenicity can be affected by derivatization of the lysine residue, as the recognition of lipoylated PDC-E2 by patient autoantibodies is enhanced compared with octanoylated PDC-E2.	Lysine	78-84	dihydrolipoamide S-acetyltransferase	Homo sapiens	127-133
15558739-3	2004	More importantly, the immunogenicity can be affected by derivatization of the lysine residue, as the recognition of lipoylated PDC-E2 by patient autoantibodies is enhanced compared with octanoylated PDC-E2.	Lysine	78-84	dihydrolipoamide S-acetyltransferase	Homo sapiens	199-205
15558739-5	2004	The only purported regulatory system that prevents the accumulation of potentially autoreactive PDC-E2 is glutathionylation, in which the lysine-lipoic acid moiety is further modified with glutathione during apoptosis.	Lysine	138-144	dihydrolipoamide S-acetyltransferase	Homo sapiens	96-102
15558739-8	2004	In this review the authors survey the data available on the biochemical life of PDC-E2, with particular emphasis on the lysine residue and its known interactions with machinery involved in various posttranslational modifications.	Lysine	120-126	dihydrolipoamide S-acetyltransferase	Homo sapiens	80-86
15557191-10	2004	These results indicate that the extracellular TLR4 domain-MD-2 complex is capable of binding LPS, and that the extracellular TLR4 domain consisting of Glu(24)-Lys(631) enables MD-2 binding and LPS recognition to TLR4.	Lysine	159-162	toll-like receptor 4	Rattus norvegicus	125-129
15375179-2	2004	We previously reported that a lysine-rich, alpha-helical peptide spanning human apoB amino acids 4372-4392 was an effective inhibitor of Lp(a) assembly in vitro.	Lysine	30-36	apolipoprotein B	Homo sapiens	80-84
15572695-4	2004	Keap1 assembles into a functional E3 ubiquitin ligase complex with Cul3 and Rbx1 that targets multiple lysine residues located in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation both in vivo and in vitro.	Lysine	103-109	kelch like ECH associated protein 1	Homo sapiens	0-5
15542849-6	2004	Finally, we have located a key lysine residue that is both a substrate for CBP acetylation and required for Sin3A interaction.	Lysine	31-37	CREB binding protein	Homo sapiens	75-78
15572695-4	2004	Keap1 assembles into a functional E3 ubiquitin ligase complex with Cul3 and Rbx1 that targets multiple lysine residues located in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation both in vivo and in vitro.	Lysine	103-109	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
15477010-8	2004	The cyt c-derived protein radicals formed by HOCl were located on lysine and tyrosine residues, with lysine predominating.	Lysine	66-72	cytochrome c, somatic	Homo sapiens	4-9
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	149-152	tumor protein p53	Homo sapiens	83-86
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	149-152	tumor protein p53	Homo sapiens	235-238
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	185-188	tumor protein p53	Homo sapiens	83-86
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	185-188	tumor protein p53	Homo sapiens	235-238
15557533-0	2004	Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP.	Lysine	63-66	prion protein	Homo sapiens	87-91
15557533-0	2004	Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP.	Lysine	67-70	prion protein	Homo sapiens	87-91
15525938-0	2004	Regulation of p53 activity through lysine methylation.	Lysine	35-41	tumor protein p53	Homo sapiens	14-17
15525938-3	2004	Here we report a novel mechanism of p53 regulation through lysine methylation by Set9 methyltransferase.	Lysine	59-65	tumor protein p53	Homo sapiens	36-39
15520273-6	2004	ELF7 and ELF8 are required for the enhancement of histone 3 trimethylation at Lys 4 in FLC chromatin.	Lysine	78-81	binding protein	Arabidopsis thaliana	9-13
15477010-8	2004	The cyt c-derived protein radicals formed by HOCl were located on lysine and tyrosine residues, with lysine predominating.	Lysine	101-107	cytochrome c, somatic	Homo sapiens	4-9
15520273-6	2004	ELF7 and ELF8 are required for the enhancement of histone 3 trimethylation at Lys 4 in FLC chromatin.	Lysine	78-81	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	87-90
15477010-9	2004	Cyt c-derived protein aggregates induced by HOCl involved primarily lysine residues and hydrophobic interaction.	Lysine	68-74	cytochrome c, somatic	Homo sapiens	0-5
15465032-7	2004	Thereafter, using a series of lysine mutants in the ODD domain, we found that HIF-1alpha was sumoylated at Lys(391) and Lys(477), suggesting that sumoylation at these two lysine residues enhances HIF-1alpha stability by possibly modulating other post-translational modifications.	Lysine	30-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
15326185-4	2004	Exposure of cells to 36 mm glucose over 96 h caused an mRNA-dependent increase in tTg activity with a 25% increase in extracellular matrix (ECM)-associated tTg and a 150% increase in ECM epsilon(gamma-glutamyl)lysine cross-linking.	Lysine	210-216	transglutaminase 2	Homo sapiens	82-85
15280381-1	2004	Set1p methylates lysine 4 of histone H3 and can activate transcription by recruiting the chromatin-remodeling factor Isw1p.	Lysine	17-23	chromatin-remodeling ATPase ISW1	Saccharomyces cerevisiae S288C	117-122
15465032-7	2004	Thereafter, using a series of lysine mutants in the ODD domain, we found that HIF-1alpha was sumoylated at Lys(391) and Lys(477), suggesting that sumoylation at these two lysine residues enhances HIF-1alpha stability by possibly modulating other post-translational modifications.	Lysine	107-110	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Lysine	124-127	Serpin 42Da	Drosophila melanogaster	69-74
15465032-7	2004	Thereafter, using a series of lysine mutants in the ODD domain, we found that HIF-1alpha was sumoylated at Lys(391) and Lys(477), suggesting that sumoylation at these two lysine residues enhances HIF-1alpha stability by possibly modulating other post-translational modifications.	Lysine	120-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
15465032-7	2004	Thereafter, using a series of lysine mutants in the ODD domain, we found that HIF-1alpha was sumoylated at Lys(391) and Lys(477), suggesting that sumoylation at these two lysine residues enhances HIF-1alpha stability by possibly modulating other post-translational modifications.	Lysine	171-177	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	89-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	89-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	98-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	98-101	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
15520190-5	2004	We find here that both WT1 isoforms are directly sumoylated on lysine residues 73 and 177.	Lysine	63-69	WT1 transcription factor	Homo sapiens	23-26
15368273-0	2004	Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity.	Lysine	55-61	toll like receptor 2	Homo sapiens	129-149
15322122-1	2004	To further understand the role that the hepatitis B virus X-associated protein 2 (XAP2) plays in regulating aryl hydrocarbon receptor (AhR) function, a point mutation was introduced at tyrosine 408 of the AhR, changing the residue to an alanine or lysine.	Lysine	248-254	aryl hydrocarbon receptor interacting protein	Homo sapiens	82-86
15507114-3	2004	We have found PPARgamma2 and its isoform, PPARgamma1, to be modified by small ubiquitin-related modifier (SUMO)-1 in vivo, at a lysine residue in the repression domain.	Lysine	128-134	small ubiquitin-like modifier 1	Mus musculus	78-113
15326173-0	2004	Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine.	Lysine	98-104	metacaspase 9	Arabidopsis thaliana	31-36
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Lysine	32-38	one cut homeobox 1	Homo sapiens	16-20
15383321-3	2004	In this paper, we describe a novel protein LYsine-RIch CEACAM1 co-isolated (LYRIC) that is widely expressed and highly conserved between species.	Lysine	43-49	metadherin	Homo sapiens	76-81
15280358-9	2004	ZNF76 is sumoylated by PIAS1 at lysine 411, which is in the minimal TBP-interacting region.	Lysine	32-38	zinc finger protein 76	Homo sapiens	0-5
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Lysine	32-38	CREB binding protein	Homo sapiens	84-87
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Lysine	32-38	one cut homeobox 1	Homo sapiens	123-127
15280365-5	2004	The UbL domain of A1Up is ubiquitinated by both Lys(48)-linked and Lys(63)-linked chains.	Lysine	48-51	ubiquilin 4	Homo sapiens	18-22
15453706-0	2004	ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f(47-51)].	Lysine	65-68	angiotensin I converting enzyme	Homo sapiens	0-3
15273251-8	2004	Acetylation of Lys(43) also reduces the interaction between NF-E4 and HDAC1, potentially maximizing the activating ability of the factor at the gamma-promoter.	Lysine	15-18	histone deacetylase 1	Homo sapiens	70-75
15449938-0	2004	Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.	Lysine	14-20	NK2 homeobox 1	Homo sapiens	74-104
15449938-7	2004	Site-specific mutagenesis identifies that the lysine residue at position 182 in the TTF-1 HD is acetylated in respiratory epithelial cells.	Lysine	46-52	NK2 homeobox 1	Homo sapiens	84-89
15529550-3	2004	Lipid oxidation results in the generation of aldehydes that substitute lysine residues in the apolipoprotein B-100 moiety.	Lysine	71-77	apolipoprotein B	Homo sapiens	94-114
15467435-12	2004	However, higher cell densities were associated with increased acetylation of histone 3 at lysine 9 in RARbeta1 but not in RARbeta2.	Lysine	90-96	retinoic acid receptor beta	Homo sapiens	102-110
15254040-0	2004	The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system.	Lysine	111-117	cyclin dependent kinase inhibitor 2A	Homo sapiens	29-32
15254040-0	2004	The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system.	Lysine	111-117	cyclin dependent kinase inhibitor 2A	Homo sapiens	33-38
15254040-7	2004	Here we demonstrate that an important group of proteins that are targeted via N-terminal ubiquitination are the naturally occurring lysine-less proteins such as the human papillomavirus (HPV)-58 E7 oncoprotein and the cell cycle inhibitor and tumor suppressor p16(INK4a).	Lysine	132-138	cyclin dependent kinase inhibitor 2A	Homo sapiens	260-263
15254040-7	2004	Here we demonstrate that an important group of proteins that are targeted via N-terminal ubiquitination are the naturally occurring lysine-less proteins such as the human papillomavirus (HPV)-58 E7 oncoprotein and the cell cycle inhibitor and tumor suppressor p16(INK4a).	Lysine	132-138	cyclin dependent kinase inhibitor 2A	Homo sapiens	264-269
15280365-5	2004	The UbL domain of A1Up is ubiquitinated by both Lys(48)-linked and Lys(63)-linked chains.	Lysine	67-70	ubiquilin 4	Homo sapiens	18-22
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Lysine	165-171	hemolytic complement	Mus musculus	227-230
15231870-10	2004	Our results demonstrate that the binding site residues at position lysine 74 in mGluR4, glutamine 58 in mGluR6, and asparagine 74 in mGluR7 are key determinants of agonist affinity and that additional residues situated outside of the binding pocket, including those present in the extreme amino terminus, also contribute to agonist affinity and the pharmacological profiles of the group III mGluRs.	Lysine	67-73	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	80-86
15293224-4	2004	Here, we demonstrate that p34(cdc2) kinase activity and protein synthesis are responsible for the activation of histone deacetylases and the inhibition of histone acetyltransferases (HATs), respectively, resulting in deacetylation of histone H4 at lysine-12 (H4K12) during mouse oocyte meiosis.	Lysine	248-254	alpha- and gamma-adaptin binding protein	Mus musculus	26-29
15258251-7	2004	We found that lysine 204 of Galpha13 is important for interaction with the RGS domain of p115 or LARG and for the GTPase-activating protein activity of these proteins.	Lysine	14-20	paired like homeodomain 2	Homo sapiens	75-78
15258251-9	2004	We conclude that lysine 204 of Galpha13 is important for interaction with RGS-RhoGEFs and is critically involved in the regulation of their activity.	Lysine	17-23	paired like homeodomain 2	Homo sapiens	74-77
15231870-10	2004	Our results demonstrate that the binding site residues at position lysine 74 in mGluR4, glutamine 58 in mGluR6, and asparagine 74 in mGluR7 are key determinants of agonist affinity and that additional residues situated outside of the binding pocket, including those present in the extreme amino terminus, also contribute to agonist affinity and the pharmacological profiles of the group III mGluRs.	Lysine	67-73	glutamate receptor, ionotropic, kainate 3	Mus musculus	133-139
15456858-4	2004	In contrast, we find that the effect of rpd3 gene disruption on global gene expression is considerably reduced in either a histone H3Delta1-28 (H3 lacking the amino-terminal 28 amino acids) or a histone H4(K5,8,12,16Q) (H4 with lysine residues 5, 8, 12, and 16 changed to glutamine residues) background compared to the wild-type background, indicating a requirement for one or both of these histone tails in Rpd3p-mediated regulation for many genes.	Lysine	228-234	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	40-44
15367670-6	2004	Characterization of the Kap121p-Nop1p and Kap121p-Sof1p interactions demonstrated that, in addition to lysine-rich nuclear localization signals (NLSs), Kap121p recognizes a unique class of signals distinguished by the abundance of arginine and glycine residues and consequently termed rg-NLSs.	Lysine	103-109	rRNA-processing protein SOF1	Saccharomyces cerevisiae S288C	50-55
15362870-0	2004	Identification of factor XIIIA-reactive glutamine acceptor and lysine donor sites within fibronectin-binding protein (FnbA) from Staphylococcus aureus.	Lysine	63-69	fibronectin 1	Homo sapiens	89-100
15556297-3	2004	PAPA-1 was found to be localized in the nucleolus in transfected HeLa cells, and the lysine/histidine cluster was essential for nucleolar localization of PAPA-1.	Lysine	85-91	INO80 complex subunit B	Homo sapiens	154-160
15362870-4	2004	In this study, the above probes were utilized for site-specific labeling and identification of reactive Gln and Lys residues targeted by factor XIIIa in rFnbA.	Lysine	112-115	coagulation factor XIII A chain	Homo sapiens	137-149
15245332-2	2004	In the present paper, we have characterized maize (Zea mays L.) photosynthetic NADP(+)-ME mutants in which conserved basic residues (lysine and arginine) were changed by site-directed mutagenesis.	Lysine	133-139	NADP-dependent malic enzyme	Zea mays	79-89
15247275-9	2004	Lys(119) and Arg(129) are the key amino acid residues in both nuclear and nucleolar localization, whereas Lys(128) regulates only nucleolar localization of 18-kDa FGF-2.	Lysine	106-109	fibroblast growth factor 2	Homo sapiens	163-168
15233625-5	2004	The free side chain of lysine, replacing the isoleucine residue at P6 position in the angiotensinogen sequence, contributed to the increased value for k(cat).	Lysine	23-29	angiotensinogen	Homo sapiens	86-101
15245332-3	2004	Kinetic characterization and oxaloacetate partition ratio of the NADP(+)-ME K255I (Lys-255--&gt;Ile) mutant suggest that the mutated lysine residue is implicated in catalysis and substrate binding.	Lysine	83-86	NADP-dependent malic enzyme	Zea mays	65-75
15313417-7	2004	Point mutations at the lysine residue within the acetylation motif of the AR and ERalpha have been identified in prostate cancer as well as in breast cancer tissue.	Lysine	23-29	estrogen receptor 1	Homo sapiens	74-88
15245332-3	2004	Kinetic characterization and oxaloacetate partition ratio of the NADP(+)-ME K255I (Lys-255--&gt;Ile) mutant suggest that the mutated lysine residue is implicated in catalysis and substrate binding.	Lysine	133-139	NADP-dependent malic enzyme	Zea mays	65-75
15325847-4	2004	In this study, we observed that the stimulation of FPRL1 by Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) caused serine phosphorylation but not tyrosine phosphorylation of STAT3 in a pertussis toxin-sensitive manner.	Lysine	64-67	signal transducer and activator of transcription 3	Homo sapiens	161-166
15245332-7	2004	On the other hand, Lys-435 and/or Lys-436 are implicated in the coenzyme specificity (NADP(+) versus NAD(+)) of maize NADP(+)-ME by interacting with the 2"-phosphate group of the ribose ring.	Lysine	19-22	NADP-dependent malic enzyme	Zea mays	118-128
15245332-7	2004	On the other hand, Lys-435 and/or Lys-436 are implicated in the coenzyme specificity (NADP(+) versus NAD(+)) of maize NADP(+)-ME by interacting with the 2"-phosphate group of the ribose ring.	Lysine	34-37	NADP-dependent malic enzyme	Zea mays	118-128
15350139-3	2004	To identify key domains of IGF-1 involved in the interaction with IGFBP-2 and IGFBP-3, we employed IGF-1 selectively biotinylated on residues Gly 1, Lys 27, Lys 65, and Lys 68.	Lysine	149-152	insulin like growth factor 1	Homo sapiens	27-32
15350139-9	2004	In BIAcore analysis, IGFBP-2 and IGFBP-3 bound only to the N(epsilon)(Lys65/68b)-IGF-1-coated flowcell of a biosensor chip, confirming the inaccessibility of Gly 1 and Lys 27 when IGF-1 is bound to IGFBP-2 and IGFBP-3.	Lysine	70-73	insulin like growth factor 1	Homo sapiens	81-86
15448012-2	2004	In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13.	Lysine	145-151	interleukin 13	Mus musculus	32-37
15448012-2	2004	In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13.	Lysine	145-151	interleukin 13	Mus musculus	45-50
15448012-2	2004	In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13.	Lysine	145-151	interleukin 13	Mus musculus	45-50
15448012-2	2004	In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13.	Lysine	145-151	interleukin 13	Mus musculus	45-50
15448012-2	2004	In addition, we have shown that IL-13 mutant IL-13E13K, in which glutamic acid (E) residue at position 13 of IL-13 molecule was substituted by a lysine (K), is a powerful antagonist of IL-13 and binds to IL-13 receptor with a higher affinity compared with wild-type IL-13.	Lysine	145-151	interleukin 13	Mus musculus	45-50
15350139-3	2004	To identify key domains of IGF-1 involved in the interaction with IGFBP-2 and IGFBP-3, we employed IGF-1 selectively biotinylated on residues Gly 1, Lys 27, Lys 65, and Lys 68.	Lysine	157-160	insulin like growth factor 1	Homo sapiens	27-32
15350139-3	2004	To identify key domains of IGF-1 involved in the interaction with IGFBP-2 and IGFBP-3, we employed IGF-1 selectively biotinylated on residues Gly 1, Lys 27, Lys 65, and Lys 68.	Lysine	157-160	insulin like growth factor 1	Homo sapiens	27-32
15311210-4	2004	Synthetic siRNAs targeted to CpG islands of an E-cadherin promoter induced significant DNA methylation and histone H3 lysine 9 methylation in both MCF-7 and normal mammary epithelial cells.	Lysine	118-124	cadherin 1	Homo sapiens	47-57
15377163-8	2004	When HSA was incubated with MCI without GSH, three peptides modified at histidine residues were characterized while when HSA was incubated in the presence of GSH, five peptides modified at histidine and lysine residues were identified.	Lysine	203-209	albumin	Homo sapiens	5-8
15377163-11	2004	Comparison of HSA-MCI and HSA-MCI-GSH samples confirmed that the presence of GSH increased the modification of lysine residues.	Lysine	111-117	albumin	Homo sapiens	14-17
15377163-11	2004	Comparison of HSA-MCI and HSA-MCI-GSH samples confirmed that the presence of GSH increased the modification of lysine residues.	Lysine	111-117	albumin	Homo sapiens	26-29
15379716-7	2004	The active form, TAFIa, inhibits fibrinolysis by cleaving off C-terminal lysine residues from partially degraded fibrin that stimulates the tissue-type plasminogen activator-mediated conversion of plasminogen to plasmin.	Lysine	73-79	plasminogen activator, tissue type	Homo sapiens	140-173
15279952-2	2004	The first step in the post-translational biosynthesis of hypusine, the transfer of an aminobutyl moiety from the polyamine substrate spermidine to the -amino group of a specific lysine residue in the eIF-5A precursor, is catalyzed by the enzyme deoxyhypusine synthase.	Lysine	178-184	deoxyhypusine synthase	Homo sapiens	245-267
15312251-2	2004	We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.	Lysine	54-60	PDB1	Homo sapiens	134-137
15312251-11	2004	We conclude that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to the development of sporadic PDB and familial PDB that is not caused by SQSTM1 mutations.	Lysine	57-63	PDB1	Homo sapiens	138-141
15296952-7	2004	Examples are given for Poly-L-lysine alone or in combination with receptor specific targeting ligands such as asialoglycoprotein, galactose, growth factors or transferrin.	Lysine	23-36	transferrin	Homo sapiens	159-170
15518711-4	2004	Using glutaraldehyde and lysine we constructed crosslinked hemoglobin, containing SOD and catalase, and assessed its ability to protect against ischemia/reperfusion injury during transplantation.	Lysine	25-31	catalase	Homo sapiens	59-98
15199058-0	2004	The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition.	Lysine	18-21	immunoglobulin heavy constant epsilon	Homo sapiens	35-51
15327775-0	2004	Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.	Lysine	66-72	methyl-CpG binding domain protein 1	Homo sapiens	27-31
15327775-0	2004	Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.	Lysine	66-72	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	78-84
15159396-11	2004	E255I-Kex2 exhibited significantly decreased recognition of P(4) Arg in a tetrapeptide substrate with Lys at P(1), although the general pattern of selectivity for aliphatic residues at P(4) remained unchanged.	Lysine	102-105	exosome component 10	Homo sapiens	60-64
15208321-10	2004	By mutating predicted SUMO consensus sites, we defined two important target lysines for SUMOylation in PLAG1, Lys-244 and Lys-263.	Lysine	76-83	PLAG1 zinc finger	Homo sapiens	103-108
15180994-4	2004	Methylation of lysine 4 of H3 via Set1, a component of the Saccharomyces cerevisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquitination Rad6-Bre1 complexes, which are required for the expression of a subset of genes.	Lysine	15-21	Paf1p	Saccharomyces cerevisiae S288C	148-152
15208321-10	2004	By mutating predicted SUMO consensus sites, we defined two important target lysines for SUMOylation in PLAG1, Lys-244 and Lys-263.	Lysine	110-113	PLAG1 zinc finger	Homo sapiens	103-108
15208321-10	2004	By mutating predicted SUMO consensus sites, we defined two important target lysines for SUMOylation in PLAG1, Lys-244 and Lys-263.	Lysine	122-125	PLAG1 zinc finger	Homo sapiens	103-108
15302922-9	2004	Lys-174 was found critical for apaf1 expression inactivation.	Lysine	0-3	apoptotic peptidase activating factor 1	Homo sapiens	31-36
15302922-10	2004	A DNA-free p53 structure model predicts that Arg-174 is important for dimerization, whereas Spalax Lys-174 prevents such interactions.	Lysine	99-102	tumor protein p53	Homo sapiens	11-14
15274630-6	2004	These differences result from the exposure or sequestration of specific cysteine or lysine residues when the enzyme is activated, either physiologically with thrombin or nonproteolytically by exposure to calcium.	Lysine	84-90	coagulation factor II, thrombin	Homo sapiens	158-166
15258597-5	2004	The amino-terminal domain of A20, which is a de-ubiquitinating (DUB) enzyme of the OTU (ovarian tumour) family, removes lysine-63 (K63)-linked ubiquitin chains from receptor interacting protein (RIP), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex.	Lysine	120-126	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	239-253
15258597-5	2004	The amino-terminal domain of A20, which is a de-ubiquitinating (DUB) enzyme of the OTU (ovarian tumour) family, removes lysine-63 (K63)-linked ubiquitin chains from receptor interacting protein (RIP), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex.	Lysine	120-126	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	255-260
15276160-0	2004	Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts.	Lysine	78-84	cytochrome c, somatic	Homo sapiens	16-28
15269344-6	2004	We show that the recruitment of G9a to the human p21(waf1/cdi1) promoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter.	Lysine	202-205	cyclin dependent kinase inhibitor 1A	Homo sapiens	49-52
15070828-7	2004	Ovine TKDP-3 and bovine TKDP-4 had P1 lysines and inhibited trypsin and plasmin with K(i) values only approximately 10-fold higher than that of BPTI.	Lysine	38-45	trophoblast Kunitz domain protein 1	Bos taurus	6-12
15215206-4	2004	HP1 associates with centric heterochromatin through an interaction with methylated lysine 9 of histone H3, a modification generated by SU(VAR)3-9.	Lysine	83-89	Suppressor of variegation 205	Drosophila melanogaster	0-3
15289458-5	2004	Mouse p19Arf, although highly basic (22% arginine content), contains only a single lysine residue absent from human p14ARF, and substitution of arginine for lysine in mouse p19Arf had no effect on its rate of degradation.	Lysine	157-163	cyclin dependent kinase inhibitor 2A	Mus musculus	173-179
15289458-6	2004	Mouse p19Arf (either wild-type or lacking lysine) and human p14ARF undergo N-terminal polyubiquitination, a process that has not as yet been documented in naturally occurring lysine-less proteins.	Lysine	42-48	cyclin dependent kinase inhibitor 2A	Mus musculus	6-12
15289458-6	2004	Mouse p19Arf (either wild-type or lacking lysine) and human p14ARF undergo N-terminal polyubiquitination, a process that has not as yet been documented in naturally occurring lysine-less proteins.	Lysine	175-181	cyclin dependent kinase inhibitor 2A	Mus musculus	6-12
15289458-6	2004	Mouse p19Arf (either wild-type or lacking lysine) and human p14ARF undergo N-terminal polyubiquitination, a process that has not as yet been documented in naturally occurring lysine-less proteins.	Lysine	175-181	cyclin dependent kinase inhibitor 2A	Homo sapiens	60-66
15299065-2	2004	METHODS: Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer.	Lysine	106-112	vasoactive intestinal peptide	Homo sapiens	40-43
15299065-2	2004	METHODS: Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer.	Lysine	114-117	vasoactive intestinal peptide	Homo sapiens	40-43
15154005-9	2004	Activating mutations of KIT were found in 14 (50%) GISTs, the majority being within exon 11 (n=11; 39.2%), and the other comprised exon 9 AY 502-503 duplications (n=2; 7.2%) and exon 17 Lys --&gt; Aln822 missense mutations (n=1; 3.6%).	Lysine	186-189	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	24-27
15297722-3	2004	Among phage libraries displaying various mutant TNF-alphas, we isolated some lysine-deficient super mutant TNF-alphas, typified by mTNF-alpha-K90R, with higher TNF-receptor affinities and stronger bioactivity in vitro, in spite of the importance of lysine residues for trimer formation and receptor binding.	Lysine	77-83	tumor necrosis factor	Homo sapiens	48-51
15297722-3	2004	Among phage libraries displaying various mutant TNF-alphas, we isolated some lysine-deficient super mutant TNF-alphas, typified by mTNF-alpha-K90R, with higher TNF-receptor affinities and stronger bioactivity in vitro, in spite of the importance of lysine residues for trimer formation and receptor binding.	Lysine	77-83	tumor necrosis factor	Homo sapiens	107-110
15297722-3	2004	Among phage libraries displaying various mutant TNF-alphas, we isolated some lysine-deficient super mutant TNF-alphas, typified by mTNF-alpha-K90R, with higher TNF-receptor affinities and stronger bioactivity in vitro, in spite of the importance of lysine residues for trimer formation and receptor binding.	Lysine	77-83	tumor necrosis factor	Homo sapiens	107-110
15297722-3	2004	Among phage libraries displaying various mutant TNF-alphas, we isolated some lysine-deficient super mutant TNF-alphas, typified by mTNF-alpha-K90R, with higher TNF-receptor affinities and stronger bioactivity in vitro, in spite of the importance of lysine residues for trimer formation and receptor binding.	Lysine	249-255	tumor necrosis factor	Homo sapiens	107-110
15297722-3	2004	Among phage libraries displaying various mutant TNF-alphas, we isolated some lysine-deficient super mutant TNF-alphas, typified by mTNF-alpha-K90R, with higher TNF-receptor affinities and stronger bioactivity in vitro, in spite of the importance of lysine residues for trimer formation and receptor binding.	Lysine	249-255	tumor necrosis factor	Homo sapiens	107-110
15264846-3	2004	Here, we show that silicas synthesized with poly-L-lysine in a alpha-helix conformation possess cylindrical pores that are approximately 1.5 nm in size, whereas silicas synthesized with poly-L-lysine in a beta-sheet conformation possess larger pores, the size of which are a function of the poly-L-lysine concentration, or in other words the size of the aggregate.	Lysine	186-199	amyloid beta precursor protein	Homo sapiens	203-209
15264846-3	2004	Here, we show that silicas synthesized with poly-L-lysine in a alpha-helix conformation possess cylindrical pores that are approximately 1.5 nm in size, whereas silicas synthesized with poly-L-lysine in a beta-sheet conformation possess larger pores, the size of which are a function of the poly-L-lysine concentration, or in other words the size of the aggregate.	Lysine	186-199	amyloid beta precursor protein	Homo sapiens	203-209
15152005-8	2004	Analysis of charged residues in the N-terminal domain revealed an essential role of Lys(35)/Lys(36) and Glu(25)/Glu(26) on enzymatic activity, suggesting that these residues are responsible for the observed stabilizing effect of the N-terminal membrane anchor on the catalytic domain of 11beta-HSD1.	Lysine	84-87	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	287-298
15143057-7	2004	Interestingly, in the PKCiota PB1 domain a conserved lysine residue was located on the side opposite to the OPCA motif-presenting surface, suggesting dual roles for the PKCiota PB1 domain in that it could interact with either the conserved lysine residue or the acidic residues on the OPCA motif of the target PB1 domains.	Lysine	53-59	ATPase plasma membrane Ca2+ transporting 3	Homo sapiens	108-112
15143057-7	2004	Interestingly, in the PKCiota PB1 domain a conserved lysine residue was located on the side opposite to the OPCA motif-presenting surface, suggesting dual roles for the PKCiota PB1 domain in that it could interact with either the conserved lysine residue or the acidic residues on the OPCA motif of the target PB1 domains.	Lysine	53-59	ATPase plasma membrane Ca2+ transporting 3	Homo sapiens	285-289
15143057-7	2004	Interestingly, in the PKCiota PB1 domain a conserved lysine residue was located on the side opposite to the OPCA motif-presenting surface, suggesting dual roles for the PKCiota PB1 domain in that it could interact with either the conserved lysine residue or the acidic residues on the OPCA motif of the target PB1 domains.	Lysine	240-246	ATPase plasma membrane Ca2+ transporting 3	Homo sapiens	108-112
15143057-7	2004	Interestingly, in the PKCiota PB1 domain a conserved lysine residue was located on the side opposite to the OPCA motif-presenting surface, suggesting dual roles for the PKCiota PB1 domain in that it could interact with either the conserved lysine residue or the acidic residues on the OPCA motif of the target PB1 domains.	Lysine	240-246	ATPase plasma membrane Ca2+ transporting 3	Homo sapiens	285-289
15226371-9	2004	Reattachment to immobilized fibronectin resulted in a gradual recovery of Rho-kinase-induced ppMLC(T18/S19) that is absent from the cells attached to poly-L-lysine.	Lysine	150-163	fibronectin 1	Homo sapiens	28-39
15196993-0	2004	Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base.	Lysine	114-120	cystathionine beta-synthase	Homo sapiens	71-98
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Lysine	118-121	Serpin 42Da	Drosophila melanogaster	23-28
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Lysine	118-121	Serpin 42Da	Drosophila melanogaster	93-98
15123625-3	2004	Sumoylation of PPARgamma mainly occurs at a lysine residue within the activation function 1 domain.	Lysine	44-50	peroxisome proliferator activated receptor gamma	Homo sapiens	15-24
15107829-4	2004	Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes.	Lysine	76-82	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-6
15123687-9	2004	Mutations of the lysine residues at the AR acetylation site reduced trichostatin A (TSA) responsiveness and ligand-induced phosphorylation of the AR.	Lysine	17-23	androgen receptor	Homo sapiens	40-42
15123687-9	2004	Mutations of the lysine residues at the AR acetylation site reduced trichostatin A (TSA) responsiveness and ligand-induced phosphorylation of the AR.	Lysine	17-23	androgen receptor	Homo sapiens	146-148
15123687-12	2004	Together these studies suggest that acetylation and phosphorylation of the AR are linked events and that the conserved AR lysine motif contributes to a select subset of pathways governing AR activity.	Lysine	122-128	androgen receptor	Homo sapiens	75-77
15123687-12	2004	Together these studies suggest that acetylation and phosphorylation of the AR are linked events and that the conserved AR lysine motif contributes to a select subset of pathways governing AR activity.	Lysine	122-128	androgen receptor	Homo sapiens	119-121
15248023-3	2004	ATF-lys10 was composed of the amino-terminal fragment of urokinase and ten lysines at the carboxyl terminus.	Lysine	75-82	glial cell derived neurotrophic factor	Homo sapiens	0-3
15231737-9	2004	Importantly, recruitment of Suz12, Ezh2 and Eed to target promoters coincides with methylation of histone H3 on Lys 27.	Lysine	112-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	35-39
15298182-4	2004	Using two different protocols of solid-phase peptide synthesis, two fluorescent octapeptides were prepared corresponding to the position B23-B30 of human insulin, each with a different fluorescent label, NBD or MCA, on the epsilon-amino group of lysine.	Lysine	246-252	insulin	Homo sapiens	154-161
15208638-0	2004	Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.	Lysine	80-83	Met4p	Saccharomyces cerevisiae S288C	63-67
15208638-3	2004	Here we show that a single ubiquitin chain is attached to Met4 through lysine at position 163.	Lysine	71-77	Met4p	Saccharomyces cerevisiae S288C	58-62
15208638-4	2004	Inhibition of Met4 ubiquitination by mutating lysine to arginine at this position constitutively activates, but does not stabilize, Met4.	Lysine	46-52	Met4p	Saccharomyces cerevisiae S288C	14-18
15208638-6	2004	Surprisingly, the ubiquitin chain attached to Met4 is linked through Lys 48 in ubiquitin, a ubiquitin chain structure that is usually required for substrate targeting to the 26S proteasome.	Lysine	69-72	Met4p	Saccharomyces cerevisiae S288C	46-50
15242590-3	2004	We show that a phenylalanine in the +3 position from the phosphoserine of BACH1 is bound to a conserved hydrophobic pocket formed between the two BRCT domains and that recognition of the phosphate group is mediated by lysine and serine side chains from the amino-terminal BRCT domain.	Lysine	218-224	BTB domain and CNC homolog 1	Homo sapiens	74-79
15189996-10	2004	Therefore, we identified and describe a novel chimeric SPE3-LYS9 gene, which may link spermidine and lysine biosynthesis in C. neoformans.	Lysine	101-107	spermidine synthase	Saccharomyces cerevisiae S288C	55-59
15173587-3	2004	Here, we demonstrate that the erythroid transcription factor GATA-1 is sumoylated in vitro and in vivo and map the single lysine residue involved in SUMO-1 attachment.	Lysine	122-128	GATA binding protein 1	Homo sapiens	61-67
15069073-1	2004	Tissue transglutaminase (TG2) is a ubiquitous enzyme that cross-links glutamine residues with lysine residues, resulting in protein polymerization, cross-linking of dissimilar proteins, and incorporation of diamines and polyamines into proteins.	Lysine	94-100	transglutaminase 2	Homo sapiens	0-23
15157086-7	2004	In contrast, UCH-L3 exhibited minor amino acid preferences at P2" " and P4" " and a 10-fold preference for the basic residues Arg and Lys at P3" ".	Lysine	134-137	ubiquitin C-terminal hydrolase L3	Homo sapiens	13-19
15255178-4	2004	Cleavage of prohormone processing sites by secretory vesicle cathepsin L occurs at the NH2-terminal side of dibasic residues, as well as between the dibasic residues, resulting in peptide intermediates with Arg or Lys extensions at their NH2-termini.	Lysine	214-217	cathepsin L	Homo sapiens	61-72
15078870-2	2004	In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center.	Lysine	65-68	leukotriene A4 hydrolase	Homo sapiens	34-50
15078870-10	2004	In conclusion, Arg(563) and Lys(565) possess distinct roles as carboxylate recognition sites for two chemically different substrates, each of which is turned over in separate enzymatic reactions catalyzed by LTA(4) hydrolase.	Lysine	28-31	leukotriene A4 hydrolase	Homo sapiens	208-224
15107469-2	2004	Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corresponding lysine residues from Cx43 eliminated the block by 2 mm spermine, reduced the transjunctional voltage (V(j)) gating sensitivity, and reduced the unitary conductance of this Cx40E9,13K gap junction channel protein.	Lysine	132-138	gap junction protein, alpha 1	Mus musculus	153-157
15150234-5	2004	A change of an invariant lysine within the putative catalytic domain abolishes this kinase activity, indicating that Stk uses a phosphotransfer mechanism similar to the mechanism used by eukaryotic PKs.	Lysine	25-31	serine/threonine protein kinase	Escherichia phage 933W	117-120
15214256-9	2004	Transferrin levels increased significantly in men, women, and children in the lysine group as compared with those in the control group.	Lysine	78-84	transferrin	Homo sapiens	0-11
15214256-11	2004	Men, women, and children in the lysine-supplemented families had significant increases in CD4, CD8, and complement C3 as compared with controls.	Lysine	32-38	CD4 molecule	Homo sapiens	90-93
15031320-1	2004	The androgen receptor (AR) can be small ubiquitin-like modifier (SUMO)-ylated in its amino-terminal domain at lysines 385 and 511.	Lysine	110-117	androgen receptor	Homo sapiens	4-21
15031320-1	2004	The androgen receptor (AR) can be small ubiquitin-like modifier (SUMO)-ylated in its amino-terminal domain at lysines 385 and 511.	Lysine	110-117	androgen receptor	Homo sapiens	23-25
15007390-0	2004	Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer.	Lysine	92-98	cyclin dependent kinase inhibitor 1C	Homo sapiens	23-29
15117318-5	2004	The serine and lysine of the BACE peptide point their side chains towards the solvent.	Lysine	15-21	beta-secretase 1	Homo sapiens	29-33
15131699-5	2004	The C-terminal hydrophobic tails of two Bcl-x(L) molecules are involved in homodimer formation, and analysis of mutants demonstrates that the C-terminal lysine residue and the G138 residue lining the BH3-binding pocket are required for homodimerization.	Lysine	153-159	BCL2 like 1	Homo sapiens	40-48
15157743-2	2004	A comparison of the amino acid sequence for MGST1 revealed one difference in exon 2 between the 129/SvJ strain (arginine at position 5) and the sequence previously reported for the Balb/c strain (lysine).	Lysine	196-202	microsomal glutathione S-transferase 1	Mus musculus	44-49
15137766-1	2004	Deuterium kinetic solvent isotope effects for the human alpha-thrombin-catalyzed hydrolysis of (1) substrates with selected P(1)-P(3) sites, Z-Pro-Arg-7-amido-4-methylcoumarin (7-AMC), N-t-Boc-Val-Pro-Arg-7-AMC, Bz-Phe-Val-Arg-4-nitroanilide (pNA), and H-D-Phe-L-Pip-Arg-pNA, are (DOD)k(cat) = (2.8-3.3) +/- 0.1 and (DOD)(k(cat)/K(m)) = (0.8-2.1) +/- 0.1 and (2) internally fluorescence-quenched substrates (a) (AB)Val-Phe-Pro-Arg-Ser-Phe-Arg-Leu-Lys(DNP)-Asp-OH, an optimal sequence, and (b) (AB)Val-Ser-Pro-Arg-Ser-Phe-Gln-Lys(DNP)-Asp-OH, recognition sequence for factor VIII, are (DOD)k(cat) = 2.2 +/- 0.2 and (DOD)(k(cat)/K(m)) = (0.8-0.9) +/- 0.1, at the pL (L = H, D) maximum, 8.4-9.0, and (25.0-26.0) +/- 0.1 degrees C. The most plausible models fitting the partial isotope effect (proton inventory) data have been selected on the basis of lowest values of the reduced chi squared and consistency of fractionation factors at all substrate concentrations, assuming rate-determining acylation.	Lysine	447-450	coagulation factor II, thrombin	Homo sapiens	62-70
15128805-4	2004	The structures confirm the presence of primary anchor residues P2-Ile/-Val and P9-/P10-Lys, and also clearly reveal the presence of secondary anchor residues P6-Ser for reverse transcriptase and P7-Met for Nef.	Lysine	87-90	S100 calcium binding protein B	Homo sapiens	206-209
15111055-8	2004	Together with previous crystal structure data, the new functional data provide a mechanistic understanding of the conserved histidine, lysine and asparagine residues found among all PLD family members.	Lysine	135-141	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	182-185
15016834-1	2004	Previous studies on the membrane-cytoplasm interphase of human integrin subunits have shown that a conserved lysine in subunits alpha(2), alpha(5), beta(1), and beta(2) is embedded in the plasma membrane in the absence of interacting proteins (Armulik, A., Nilsson, I., von Heijne, G., and Johansson, S. (1999) in J. Biol.	Lysine	109-115	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	148-155
15016834-10	2004	To test the proposed "piston" model for signaling, we forced this region at the C-terminal end of the alpha(5) and beta(1) TM domains out of the membrane into the cytosol by replacing Lys-Leu with Lys-Lys.	Lysine	184-187	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	115-122
15016834-10	2004	To test the proposed "piston" model for signaling, we forced this region at the C-terminal end of the alpha(5) and beta(1) TM domains out of the membrane into the cytosol by replacing Lys-Leu with Lys-Lys.	Lysine	197-200	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	115-122
32688904-5	2004	The metabolism of lysine was also studied by analysis of the enzymes aspartate kinase, homoserine dehydrogenase, lysine 2-oxoglutarate reductase and saccharopine dehydrogenase, which exhibited major changes in activity, depending on the genotype, suggesting that the mutant genes may have distinct regulatory activities.	Lysine	18-24	bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic	Zea mays	69-111
15132742-4	2004	RESULTS: Mutations of a highly conserved DBD lysine (ERalpha.K206A/G), lead to super-activation of AP-1 through activation function dependent pathways, up to 200 fold.	Lysine	45-51	estrogen receptor 1	Homo sapiens	53-60
15132742-9	2004	This function, which requires the integrity of the conserved lysine, both allows for activation at AP-1 with anti-estrogens (with ERbeta and ERalpha DBD-LBD), and prevents ERalpha from becoming superactive at AP-1 with estrogens.	Lysine	61-67	estrogen receptor 1	Homo sapiens	141-148
15132742-9	2004	This function, which requires the integrity of the conserved lysine, both allows for activation at AP-1 with anti-estrogens (with ERbeta and ERalpha DBD-LBD), and prevents ERalpha from becoming superactive at AP-1 with estrogens.	Lysine	61-67	estrogen receptor 1	Homo sapiens	172-179
15331327-7	2004	These results indicate that Glu13 in IL-13 associates with IL-4Ralpha, and mutation to lysine decreases its binding ability to IL-4Ralpha chain.	Lysine	87-93	interleukin 13	Homo sapiens	37-42
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	168-171	dihydrodipicolinate synthase 1	Arabidopsis thaliana	61-89
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	E3 ubiquitin-protein ligase RAD18	Saccharomyces cerevisiae S288C	160-165
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	dihydrodipicolinate synthase 1	Arabidopsis thaliana	41-45
15100319-3	2004	In these experiments, we found activation of Akt in neutrophils stimulated with the TLR2-specific ligands peptidoglycan and the lipopeptide tri-palmitoyl-S-glyceryl-Cys-Ser-(Lys)(4) that occurred earlier and was of greater magnitude than that present after exposure to the TLR4 agonist LPS.	Lysine	174-177	AKT serine/threonine kinase 1	Homo sapiens	45-48
15100319-3	2004	In these experiments, we found activation of Akt in neutrophils stimulated with the TLR2-specific ligands peptidoglycan and the lipopeptide tri-palmitoyl-S-glyceryl-Cys-Ser-(Lys)(4) that occurred earlier and was of greater magnitude than that present after exposure to the TLR4 agonist LPS.	Lysine	174-177	toll like receptor 2	Homo sapiens	84-88
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	168-171	dihydrodipicolinate synthase 1	Arabidopsis thaliana	91-95
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	207-210	dihydrodipicolinate synthase 1	Arabidopsis thaliana	61-89
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	207-210	dihydrodipicolinate synthase 1	Arabidopsis thaliana	91-95
15122025-4	2004	To address these questions, we coexpressed a bacterial DHPS gene with an RNAi construct of AtLKR/SDH, both under control of the same seed-specific promoter, to restrict Lys synthesis and catabolism to the developing seeds.	Lysine	169-172	dihydrodipicolinate synthase 1	Arabidopsis thaliana	55-59
15122025-5	2004	Coexpression of these genes boosted seed Lys content and caused a significant, metabolically unanticipated increase in Met content, similarly to our previous report using plants expressing the bacterial DHPS on an AtLKR/SDH knockout background.	Lysine	41-44	dihydrodipicolinate synthase 1	Arabidopsis thaliana	203-207
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	87-90	dihydrodipicolinate synthase 1	Arabidopsis thaliana	41-45
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	dihydrodipicolinate synthase 1	Arabidopsis thaliana	41-45
14966128-5	2004	Examination of a series of wild type and mutant Stat3 proteins demonstrated loss of binding to pYXXQ-containing peptides only in Stat3 mutated at Lys-591 or Arg-609, whose side chains interact with the Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the +3 Gln side chain when the peptide ligand assumes a beta-turn.	Lysine	146-149	signal transducer and activator of transcription 3	Homo sapiens	48-53
14747465-1	2004	Lysine insertion during coded protein synthesis requires lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synthetase (LysRS).	Lysine	0-6	lysyl-tRNA synthetase 1	Homo sapiens	98-119
14747465-1	2004	Lysine insertion during coded protein synthesis requires lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synthetase (LysRS).	Lysine	0-6	lysyl-tRNA synthetase 1	Homo sapiens	121-126
15039546-6	2004	The other recombinant CP enabled virus movement only after the introduction of two point mutations (Glu--&gt;Lys and Lys--&gt;Arg at aa 62 and 65, respectively).	Lysine	109-112	golgi phosphoprotein 3	Homo sapiens	22-24
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	264-270	tumor necrosis factor	Homo sapiens	141-168
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	264-270	tumor necrosis factor	Homo sapiens	170-179
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	264-270	nuclear factor kappa B subunit 1	Homo sapiens	193-202
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	272-275	tumor necrosis factor	Homo sapiens	141-168
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	272-275	tumor necrosis factor	Homo sapiens	170-179
14976218-5	2004	We therefore carried out chromatin immunoprecipitation (ChIP) assays in monocytes to identify 1) chromatin factors bound to the promoters of tumor necrosis factor-alpha (TNF-alpha) and related NF-kappaB-regulated genes under HG or diabetic conditions, 2) specific lysine (Lys (K)) residues on histone H3 (HH3) and HH4 acetylated in this process.	Lysine	272-275	nuclear factor kappa B subunit 1	Homo sapiens	193-202
15099518-4	2004	We show that the Ezh2 complexes exhibit differential targeting of specific histones for lysine methylation dependent upon the context of the histone substrates.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	17-21
15048777-1	2004	Brownian dynamics simulations of computer models of GAPDH mutants interacting with F-actin emphasized the electrostatic nature of such interactions, and confirmed the importance of four previously identified lysine residues on the GAPDH structure in these interactions.	Lysine	208-214	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
15048777-1	2004	Brownian dynamics simulations of computer models of GAPDH mutants interacting with F-actin emphasized the electrostatic nature of such interactions, and confirmed the importance of four previously identified lysine residues on the GAPDH structure in these interactions.	Lysine	208-214	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	231-236
14987625-7	2004	The RyR channel agonists 4-chloro-m-cresol and poly-L-lysine significantly reduced the anesthetic potency of bupivacaine.	Lysine	47-60	ryanodine receptor 1, skeletal muscle	Mus musculus	4-7
15196462-0	2004	The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.	Lysine	51-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	22-26
15039546-6	2004	The other recombinant CP enabled virus movement only after the introduction of two point mutations (Glu--&gt;Lys and Lys--&gt;Arg at aa 62 and 65, respectively).	Lysine	117-120	golgi phosphoprotein 3	Homo sapiens	22-24
15003522-7	2004	Furthermore, lysine-121 in the inhibitory domain of KLF2 is critical for ubiquitin-conjugation.	Lysine	13-19	Kruppel like factor 2	Homo sapiens	52-56
14968111-5	2004	In both cases, however, HCV core protein increased the p53 DNA-binding affinity in gel retardation analyses, likely due to the hyperacetylation of p53 Lys(373) and Lys(382) residues.	Lysine	151-154	tumor protein p53	Homo sapiens	55-58
14968111-5	2004	In both cases, however, HCV core protein increased the p53 DNA-binding affinity in gel retardation analyses, likely due to the hyperacetylation of p53 Lys(373) and Lys(382) residues.	Lysine	151-154	tumor protein p53	Homo sapiens	147-150
14968111-5	2004	In both cases, however, HCV core protein increased the p53 DNA-binding affinity in gel retardation analyses, likely due to the hyperacetylation of p53 Lys(373) and Lys(382) residues.	Lysine	164-167	tumor protein p53	Homo sapiens	55-58
14722067-1	2004	We have recently identified in two unrelated patients with bleeding tendency a homozygous mutation causing a deletion of one of the two contiguous Lys(9)/Lys(10) residues in the A-chain of alpha-thrombin (DeltaK9).	Lysine	147-150	coagulation factor II, thrombin	Homo sapiens	195-203
14722067-1	2004	We have recently identified in two unrelated patients with bleeding tendency a homozygous mutation causing a deletion of one of the two contiguous Lys(9)/Lys(10) residues in the A-chain of alpha-thrombin (DeltaK9).	Lysine	154-157	coagulation factor II, thrombin	Homo sapiens	195-203
14722067-2	2004	We used in vitro expression analysis to clarify the role of the deletion of Lys(9) or Lys(10) in the thrombin function.	Lysine	76-79	coagulation factor II, thrombin	Homo sapiens	101-109
14722067-2	2004	We used in vitro expression analysis to clarify the role of the deletion of Lys(9) or Lys(10) in the thrombin function.	Lysine	86-89	coagulation factor II, thrombin	Homo sapiens	101-109
14676825-8	2004	In contrast, p105, the p100 homologue, lacks a similar Lys residue.	Lysine	55-58	nuclear factor kappa B subunit 1	Homo sapiens	13-17
15469705-5	2004	Additionally, rhodopsin completely protected against the DnsCl inactivation of T. These results demonstrated the existence of functional lysines on T that are located in the proximity of the interaction site with the photoreceptor protein.	Lysine	137-144	rhodopsin	Homo sapiens	14-23
14985084-1	2004	Recently, we created a lysine-deficient mutant tumor necrosis factor-alpha [mTNF-alpha-Lys(-)] with full bioactivity in vitro compared with wild-type TNF-alpha (wTNF-alpha), and site-specific PEGylation of mTNF-alpha-Lys(-) was found to selectively enhance its in vivo antitumor activity.	Lysine	23-29	tumor necrosis factor	Mus musculus	76-86
14985084-1	2004	Recently, we created a lysine-deficient mutant tumor necrosis factor-alpha [mTNF-alpha-Lys(-)] with full bioactivity in vitro compared with wild-type TNF-alpha (wTNF-alpha), and site-specific PEGylation of mTNF-alpha-Lys(-) was found to selectively enhance its in vivo antitumor activity.	Lysine	23-29	tumor necrosis factor	Homo sapiens	77-86
14985084-1	2004	Recently, we created a lysine-deficient mutant tumor necrosis factor-alpha [mTNF-alpha-Lys(-)] with full bioactivity in vitro compared with wild-type TNF-alpha (wTNF-alpha), and site-specific PEGylation of mTNF-alpha-Lys(-) was found to selectively enhance its in vivo antitumor activity.	Lysine	23-29	tumor necrosis factor	Mus musculus	206-216
14999100-4	2004	Here, we demonstrate that a single APOBEC3G residue, which is an aspartic acid in human APOBEC3G and a lysine in agm APOBEC3G, controls the ability of the HIV-1 Vif protein to bind and inactivate these host defense factors.	Lysine	103-109	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	35-43
14978281-6	2004	Replacement of Asp-128 in human APOBEC3G with the Lys-128 of AGM APOBEC3G caused the enzyme to switch its interaction, becoming sensitive to SIV(AGM) Vif and resistant to HIV-1 Vif.	Lysine	50-53	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	32-40
14978281-6	2004	Replacement of Asp-128 in human APOBEC3G with the Lys-128 of AGM APOBEC3G caused the enzyme to switch its interaction, becoming sensitive to SIV(AGM) Vif and resistant to HIV-1 Vif.	Lysine	50-53	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	65-73
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Lysine	97-100	coagulation factor II, thrombin	Homo sapiens	108-116
14978281-7	2004	Conversely, the reciprocal Lys to Asp switch in AGM APOBEC3G reversed its specificity for Vif.	Lysine	27-30	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	52-60
15004152-6	2004	Furthermore, specificity for RT1-Ac can be transferred from Ly-49W to Ly-49P, which is normally unable to recognize RT1-Ac, by substitution of three residues shared by Ly-49W and -G(BALB/c) but not Ly-49P.	Lysine	60-62	killer cell lectin-like receptor subfamily A, member 23	Mus musculus	168-174
15004152-6	2004	Furthermore, specificity for RT1-Ac can be transferred from Ly-49W to Ly-49P, which is normally unable to recognize RT1-Ac, by substitution of three residues shared by Ly-49W and -G(BALB/c) but not Ly-49P.	Lysine	70-72	killer cell lectin-like receptor subfamily A, member 23	Mus musculus	60-66
15004152-6	2004	Furthermore, specificity for RT1-Ac can be transferred from Ly-49W to Ly-49P, which is normally unable to recognize RT1-Ac, by substitution of three residues shared by Ly-49W and -G(BALB/c) but not Ly-49P.	Lysine	70-72	killer cell lectin-like receptor subfamily A, member 23	Mus musculus	168-174
15027030-9	2004	In addition we found that peptides corresponding to the Arg(255)-Ser(267), Lys(288)-Ser(298) or Pro(230)-Val(240) when presented in a multimeric form conjugated to branched chain polypeptide in uniformly oriented copies induced the release of TNFalpha, a pro-inflammatory cytokine from MonoMac monocyte cell line.	Lysine	75-78	tumor necrosis factor	Homo sapiens	243-251
15801461-5	2004	Electrostatic attachment of the protein involved ion-pair and hydrogen-bond interactions between the terminating carboxylic acid groups of the DDCA-functionalized ITO and the primary amine groups of the lysine residues of cytochrome c.	Lysine	203-209	cytochrome c, somatic	Homo sapiens	222-234
15127790-4	2004	In contrast, substitution of Trp for Lys and Thr at positions 2, 15 and 19 of HP(2-9)-ME(1-12), respectively (HM3 and HM4), decreased activity but increased hemolysis against human erythrocytes.	Lysine	37-40	cholinergic receptor muscarinic 4	Homo sapiens	118-121
15010069-6	2004	The other c-KIT mutations included exon 9 AY 502-503 duplication (n=4; 14%) and exon 13 Lys--&gt;Glu(642) missense mutation (n=1; 3%).	Lysine	88-91	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	10-15
15004521-1	2004	Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-kappaB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.	Lysine	41-47	nuclear factor kappa B subunit 1	Homo sapiens	100-109
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Lysine	188-191	TATA-box binding protein like 1	Homo sapiens	116-119
15031665-6	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Lysine	134-140	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
14645236-7	2004	In addition, an identified nuclear localization signal motif in the third intracellular loop of the apelin receptor was disrupted by a substituted glutamine in place of lysine.	Lysine	169-175	apelin	Homo sapiens	100-106
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	Janus kinase 1	Homo sapiens	70-74
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	protein kinase C alpha	Homo sapiens	153-161
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	178-183
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	signal transducer and activator of transcription 3	Homo sapiens	255-260
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	185-188	Janus kinase 1	Homo sapiens	70-74
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	185-188	protein kinase C alpha	Homo sapiens	153-161
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Lysine	180-183	TATA-box binding protein like 1	Homo sapiens	116-119
14597626-1	2004	Histone H3 methylated at lysine 4 (H3-meK4) co-localizes with hyperacetylated histones H3 and H4 in transcriptionally active chromatin, but mechanisms that establish H3-meK4 are poorly understood.	Lysine	25-31	mitogen-activated protein kinase kinase 4	Homo sapiens	38-42
14660664-8	2004	First, unlike villin headpiece that contains a single buried salt bridge, DHP contains a buried charged cluster comprising residues Glu(39), Arg(66), Lys(70), and the C-terminal carboxylate of Phe(76).	Lysine	150-153	dihydropyrimidinase	Homo sapiens	74-77
14660678-0	2004	Lysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein.	Lysine	0-6	apolipoprotein A1	Homo sapiens	71-89
14660678-11	2004	Molecular modeling of the YXXK motif in apolipoprotein A-I demonstrated that these tyrosine and lysine residues are adjacent on the same face of an amphipathic alpha-helix.	Lysine	96-102	apolipoprotein A1	Homo sapiens	40-58
14597626-1	2004	Histone H3 methylated at lysine 4 (H3-meK4) co-localizes with hyperacetylated histones H3 and H4 in transcriptionally active chromatin, but mechanisms that establish H3-meK4 are poorly understood.	Lysine	25-31	mitogen-activated protein kinase kinase 4	Homo sapiens	169-173
14594952-11	2004	In contrast, the mutants lysine 822 and 824 to alanine demonstrated the presence of an overlapping F-actin and PIP(2)-binding site in the actin cross-linking domain of villin.	Lysine	25-31	prolactin induced protein	Homo sapiens	111-114
14676184-1	2004	We report the selective inactivation of proteolytic antibodies (Abs) to an autoantigen, the neuropeptide vasoactive intestinal peptide (VIP), by a covalently reactive analog (CRA) of VIP containing an electrophilic phosphonate diester at the Lys(20) residue.	Lysine	242-245	vasoactive intestinal peptide	Homo sapiens	136-139
14676184-1	2004	We report the selective inactivation of proteolytic antibodies (Abs) to an autoantigen, the neuropeptide vasoactive intestinal peptide (VIP), by a covalently reactive analog (CRA) of VIP containing an electrophilic phosphonate diester at the Lys(20) residue.	Lysine	242-245	vasoactive intestinal peptide	Homo sapiens	183-186
14676184-8	2004	Catalytic hydrolysis of VIP by a polyclonal VIPase autoantibody preparation that cleaves multiple peptide bonds located between residues 7 and 22 essentially was inhibited completely by the VIP-CRA, suggesting that the electrophilic phosphonate at Lys(20) enjoys sufficient conformational freedom to react covalently with Abs that cleave different peptide bonds in VIP.	Lysine	248-251	vasoactive intestinal peptide	Homo sapiens	24-27
14676184-8	2004	Catalytic hydrolysis of VIP by a polyclonal VIPase autoantibody preparation that cleaves multiple peptide bonds located between residues 7 and 22 essentially was inhibited completely by the VIP-CRA, suggesting that the electrophilic phosphonate at Lys(20) enjoys sufficient conformational freedom to react covalently with Abs that cleave different peptide bonds in VIP.	Lysine	248-251	vasoactive intestinal peptide	Homo sapiens	44-47
14676184-8	2004	Catalytic hydrolysis of VIP by a polyclonal VIPase autoantibody preparation that cleaves multiple peptide bonds located between residues 7 and 22 essentially was inhibited completely by the VIP-CRA, suggesting that the electrophilic phosphonate at Lys(20) enjoys sufficient conformational freedom to react covalently with Abs that cleave different peptide bonds in VIP.	Lysine	248-251	vasoactive intestinal peptide	Homo sapiens	44-47
14712067-1	2004	We have shown that the human general transcriptional factor IB (TFIIB) auto-acetylates specifically at lysine 238 in the presence of acetyl coenzyme A in vitro.	Lysine	103-109	general transcription factor IIB	Homo sapiens	64-69
14722314-4	2004	Herein, we show that this increase in tRNA(Lys) incorporation into virions is dependent upon the ability of LysRS to bind to tRNA(Lys) but not upon its ability to aminoacylate the tRNA(Lys).	Lysine	43-46	lysyl-tRNA synthetase 1	Homo sapiens	108-113
14581473-2	2004	Studies have shown that the non-covalent step involves an interaction between the weak lysine-binding sites (WLBS) present within each of apo(a) kringle IV types 6, 7, and 8 (KIV(6-8)), and two lysine residues (Lys(680) and Lys(690)) within the NH(2) terminus of the apolipoprotein B-100 (apoB) component of low density lipoprotein.	Lysine	87-93	apolipoprotein B	Homo sapiens	267-287
14581473-2	2004	Studies have shown that the non-covalent step involves an interaction between the weak lysine-binding sites (WLBS) present within each of apo(a) kringle IV types 6, 7, and 8 (KIV(6-8)), and two lysine residues (Lys(680) and Lys(690)) within the NH(2) terminus of the apolipoprotein B-100 (apoB) component of low density lipoprotein.	Lysine	87-93	apolipoprotein B	Homo sapiens	289-293
14581473-8	2004	We also showed that KIV(7) and KIV(8) specifically bind with high affinity to apoB-derived peptides containing Lys(690) or Lys(680), respectively.	Lysine	111-114	apolipoprotein B	Homo sapiens	78-82
14581473-8	2004	We also showed that KIV(7) and KIV(8) specifically bind with high affinity to apoB-derived peptides containing Lys(690) or Lys(680), respectively.	Lysine	123-126	apolipoprotein B	Homo sapiens	78-82
14581473-9	2004	Taken together, our data demonstrate that specific interactions between apo(a) KIV(7) and KIV(8) and Lys(680) and Lys(690) in apoB mediate a high affinity non-covalent interaction between apo(a) and low density lipoprotein, which dictates the efficiency of covalent Lp(a) formation.	Lysine	101-104	apolipoprotein B	Homo sapiens	126-130
14670946-3	2004	Our studies now demonstrate that mutation of lysine residues in wild-type AR that are normally acetylated in a ligand-dependent manner mimics the effects of the expanded glutamine tract on receptor trafficking, misfolding, and aggregation.	Lysine	45-51	androgen receptor	Homo sapiens	74-76
14992727-3	2004	This menin-associated complex methylates histone H3 on lysine 4.	Lysine	55-61	menin 1	Homo sapiens	5-10
14769216-3	2004	Two kinds of polymerase chain reaction (PCR) for the site-direction mutagenesis were used to construct FALL-39 mutant expression vector, FALL-39-Lys-32 and FALL-39-Lys-24.	Lysine	145-148	cathelicidin antimicrobial peptide	Homo sapiens	103-110
14769216-3	2004	Two kinds of polymerase chain reaction (PCR) for the site-direction mutagenesis were used to construct FALL-39 mutant expression vector, FALL-39-Lys-32 and FALL-39-Lys-24.	Lysine	145-148	cathelicidin antimicrobial peptide	Homo sapiens	137-144
14769216-3	2004	Two kinds of polymerase chain reaction (PCR) for the site-direction mutagenesis were used to construct FALL-39 mutant expression vector, FALL-39-Lys-32 and FALL-39-Lys-24.	Lysine	145-148	cathelicidin antimicrobial peptide	Homo sapiens	137-144
14769216-5	2004	Effects of different solution on the antibacterial activity of FALL-39 and FALL-39-Lys-32 were observed by CFU determination.	Lysine	83-86	cathelicidin antimicrobial peptide	Homo sapiens	75-82
14769216-7	2004	RESULTS: Two site-specific mutants FALL-39-Lys-32 and FALL-39-Lys24 were obtained by PCR-induced mutagenesis.	Lysine	43-46	cathelicidin antimicrobial peptide	Homo sapiens	35-42
14769216-10	2004	The antibacterial assay showed that FALL-39-Lys-32 and FALL-39-Lys24 were more potential in the antibacterial activity against E coli ML35p and Pseudomonas aeruginosa ATCC27853 than that of FALL-39, and no increase in hemolysis was observed at the antibacterial concentrations.	Lysine	44-47	cathelicidin antimicrobial peptide	Homo sapiens	36-43
14769216-11	2004	The antibacterial activity of FALL-39-Lys-32 against E coli was more potent than that of FALL-39 in NaCl-containing LB medium, while its activity was almost the same as FALL-39 in SO4(2-) containing Medium E. CONCLUSION: PCR-based mutagenesis is a useful model system for studying the structure and function relationship of antimicrobial peptides.	Lysine	38-41	cathelicidin antimicrobial peptide	Homo sapiens	30-37
14759370-1	2004	Lysine acetylation of the tumor suppressor protein p53 in response to a wide variety of cellular stress signals is required for its activation as a transcription factor that regulates cell cycle arrest, senescence, or apoptosis.	Lysine	0-6	tumor protein p53	Homo sapiens	51-54
14759370-2	2004	Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382.	Lysine	165-171	CREB binding protein	Homo sapiens	83-86
14759370-2	2004	Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382.	Lysine	165-171	CREB binding protein	Homo sapiens	88-108
14759370-2	2004	Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382.	Lysine	165-171	tumor protein p53	Homo sapiens	132-135
14759370-4	2004	We further present the three-dimensional nuclear magnetic resonance structure of the CBP bromodomain in complex with a lysine 382-acetylated p53 peptide.	Lysine	119-125	CREB binding protein	Homo sapiens	85-88
14759370-4	2004	We further present the three-dimensional nuclear magnetic resonance structure of the CBP bromodomain in complex with a lysine 382-acetylated p53 peptide.	Lysine	119-125	tumor protein p53	Homo sapiens	141-144
14698304-0	2004	Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha.	Lysine	12-18	protein kinase C alpha	Homo sapiens	99-107
14698304-8	2004	Taken together, the results obtained showed that these lysine residues might be involved in two functions: one to establish an intramolecular interaction that keeps the enzyme in an inactive conformation; and the second, once the enzyme has been partially activated, to establish further interactions with diacylglycerol and/or acidic phospholipids, leading to the full activation of PKCalpha.	Lysine	55-61	protein kinase C alpha	Homo sapiens	384-392
14519104-8	2004	All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue.	Lysine	64-70	cullin RTT101	Saccharomyces cerevisiae S288C	22-29
14737116-7	2004	Efficient growth arrest by p16/Rb is dependent on histone H3 lysine 9 methylation, which provides a binding site for HP1.	Lysine	61-67	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-30
14519104-9	2004	These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p.	Lysine	32-38	NEDD8 family protein RUB1	Saccharomyces cerevisiae S288C	62-67
14519104-9	2004	These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p.	Lysine	32-38	cullin RTT101	Saccharomyces cerevisiae S288C	112-119
14519104-9	2004	These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p.	Lysine	32-38	NEDD8 family protein RUB1	Saccharomyces cerevisiae S288C	127-132
14705947-6	2004	On a molar basis, histones H(1) and H(3) were the most effective PARP-1 activators, and their action was abolished by acetylation of lysine end groups.	Lysine	133-139	poly(ADP-ribose) polymerase 1	Homo sapiens	65-71
14707061-4	2004	Physical linkage to DAP12 requires lysine-183 in the NKp44 transmembrane domain.	Lysine	35-41	natural cytotoxicity triggering receptor 2	Homo sapiens	53-58
14712277-5	2004	Here we show that vernalization causes changes in histone methylation in discrete domains within the FLC locus, increasing dimethylation of lysines 9 and 27 on histone H3.	Lysine	140-147	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	101-104
15123883-5	2004	Lysine at position 281, a basic residue, is more susceptible to acidification-induced blockade of the 5-HT(3)R channel.	Lysine	0-6	5-hydroxytryptamine receptor 3A	Homo sapiens	102-110
14570889-3	2004	Here we provide indirect but strong evidence for a malondialdehyde-derived cross-link requiring just one malondialdehyde molecule to link arginine and lysine, giving 2-ornithinyl-4-methyl(1epsilon-lysyl)1,3-imidazole following a 4-day incubation of albumin with 8 mm malondialdehyde.	Lysine	151-157	albumin	Homo sapiens	249-256
14584049-5	2004	Exposure of proliferating KCs to UV-light induces post-translational modifications of p53 including acetylation of lysine-382 residues.	Lysine	115-121	tumor protein p53	Homo sapiens	86-89
15068667-6	2004	We observed that Lys-105 and Arg-109 are critical for IL13 binding to IL13Ralpha2, indeed.	Lysine	17-20	interleukin 13	Homo sapiens	54-58
13130121-6	2004	Transgenic mice were created that expressed a mutant human apoB-100, apoB-100K4--&gt;S4, in which all four lysine residues in the 4,372-4,392 sequence were mutated to serines.	Lysine	107-113	apolipoprotein B	Homo sapiens	59-67
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Lysine	28-34	interleukin 13	Homo sapiens	0-4
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Lysine	28-34	interleukin 13	Homo sapiens	91-95
14506259-3	2003	The catalytic efficiency of CDK2-cyclin A is impaired 2000-, 10-, and 150-fold, when Pro+1, Lys+2, or Lys+3, respectively, is substituted with Ala in a short synthetic peptide substrate.	Lysine	92-95	cyclin A2	Homo sapiens	33-41
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Lysine	28-34	interleukin 13	Homo sapiens	91-95
15171252-6	2004	Distinct "hotspots" of histone H3 dimethylated at lysine 4 are localized at the ends of the active DJ domains of both the IgH and TCRbeta loci, suggesting they may serve as important marks for locus accessibility.	Lysine	50-56	T cell receptor beta locus	Homo sapiens	130-137
15171256-4	2004	Acetylation of these distinct lysine residues regulates different functions of NF-kappaB, including transcriptional activation, DNA binding affinity, I-kappaBalpha assembly and subcellular localization.	Lysine	30-36	nuclear factor kappa B subunit 1	Homo sapiens	79-88
15171256-4	2004	Acetylation of these distinct lysine residues regulates different functions of NF-kappaB, including transcriptional activation, DNA binding affinity, I-kappaBalpha assembly and subcellular localization.	Lysine	30-36	NFKB inhibitor alpha	Homo sapiens	150-163
15171256-5	2004	Specifically, acetylation of lysine 221 enhances DNA binding and impairs assembly with I-kappaBalpha while acetylation of lysine 310 is required for full transcriptional activity of RelA independent of changes in DNA binding or I-kappaBalpha binding.	Lysine	29-35	NFKB inhibitor alpha	Homo sapiens	87-100
15171256-7	2004	Deacetylation of lysine 221 promotes high-affinity binding of RelA to newly synthesized I-kappaBalpha proteins whose expression is activated by NF-kappaB.	Lysine	17-23	NFKB inhibitor alpha	Homo sapiens	88-101
15171256-7	2004	Deacetylation of lysine 221 promotes high-affinity binding of RelA to newly synthesized I-kappaBalpha proteins whose expression is activated by NF-kappaB.	Lysine	17-23	nuclear factor kappa B subunit 1	Homo sapiens	144-153
14728980-7	2004	Analysis of the chromatin state of the serpina3g promoter by the ChIP assay revealed that exposure of mouse fibroblast cells to Ni resulted in the methylation of H3 lysine 9 within its promoter, as well as a decrease in the phosphorylation of serine 10 of H3 and a marked decrease in the acetylation of H3 and H4.	Lysine	165-171	serine (or cysteine) peptidase inhibitor, clade A, member 3G	Mus musculus	39-48
14749535-1	2003	Deoxyhypusine is a modified lysine and formed posttranslationally to be the eukaryotic initiation factor eIF5A by deoxyhypusine synthase, employing spermidine as butylamine donor.	Lysine	28-34	deoxyhypusine synthase	Homo sapiens	114-136
14527952-6	2003	PLZF-mediated regulation of the cell cycle and transcriptional repression of the cyclin A2 gene were also dependent on sumoylation of PLZF on lysine 242.	Lysine	142-148	cyclin A2	Homo sapiens	81-90
14689561-1	2004	Upon hexanal-modification in the presence of NaCNBH(3), the oxidized B chain of insulin becomes mono- and further dialkylated on both the N-terminal and Lys(29) residues.	Lysine	153-156	insulin	Homo sapiens	80-87
14506259-4	2003	Yet, in physiological substrates of both CDK2-cyclin A and CDK2-cyclin E, it is found that Lys+2, and, occasionally, both Lys+2 and Lys+3 together are replaced with suboptimal determinants.	Lysine	91-94	cyclin A2	Homo sapiens	46-54
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	78-84	tumor protein p53	Homo sapiens	197-200
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	150-157	tumor protein p53	Homo sapiens	197-200
14661977-6	2003	Factor XIIIa catalyzes the incorporation of amine donor (dansylacadaverine) and amine acceptor (peptide patterned on the N-terminal sequence of fibronectin) synthetic probes into rFnbA, suggesting that it serves as a bifunctional substrate containing reactive glutamine and lysine residues.	Lysine	274-280	coagulation factor XIII A chain	Homo sapiens	0-12
14695212-0	2003	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.	Lysine	69-75	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	22-26
14695212-0	2003	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.	Lysine	69-75	tumor protein p53	Homo sapiens	50-53
14695184-8	2003	HIF-1alpha(785) escapes from lysine acetylation because of the loss of Lys(532) and was stabilized under normoxic conditions.	Lysine	29-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
14695184-8	2003	HIF-1alpha(785) escapes from lysine acetylation because of the loss of Lys(532) and was stabilized under normoxic conditions.	Lysine	71-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
14695212-3	2003	By Western blotting, using specific antibodies, we then demonstrated that residues 320, 373, and 382 lysines of p53 were acetylated in KATO-III cells transfected with wild-type p53 (KATO-III/p53) treated with a HDAC inhibitor.	Lysine	101-108	tumor protein p53	Homo sapiens	112-115
14695212-3	2003	By Western blotting, using specific antibodies, we then demonstrated that residues 320, 373, and 382 lysines of p53 were acetylated in KATO-III cells transfected with wild-type p53 (KATO-III/p53) treated with a HDAC inhibitor.	Lysine	101-108	tumor protein p53	Homo sapiens	177-180
14695212-3	2003	By Western blotting, using specific antibodies, we then demonstrated that residues 320, 373, and 382 lysines of p53 were acetylated in KATO-III cells transfected with wild-type p53 (KATO-III/p53) treated with a HDAC inhibitor.	Lysine	101-108	tumor protein p53	Homo sapiens	177-180
14701874-3	2003	We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1.	Lysine	110-117	SATB homeobox 2	Homo sapiens	14-19
14506238-7	2003	In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro.	Lysine	61-64	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	66-69
12949144-9	2003	In terms of the actin monomer, lysine 118 is near neither the binding sites of the major actin-binding proteins, myosin, tropomyosin, or the troponins, nor the actin polymerization sites.	Lysine	31-37	Actin 79B	Drosophila melanogaster	16-21
14517211-5	2003	The p53 accumulating in these cells was nuclear but was not phosphorylated at serines 6, 15, and 20, nor was it acetylated at lysines 373 or 382.	Lysine	126-133	tumor protein p53	Homo sapiens	4-7
14504272-5	2003	This technique identified nine peptides, which contained the acrolein adducts at Lys-29 and the N terminus, and revealed that the reaction of the insulin B chain with acrolein gave multiple adducts, including an unknown adduct containing two molecules of acrolein per lysine.	Lysine	268-274	insulin	Homo sapiens	146-153
14654786-7	2003	Silencing of CDKN2A in Tu159 cells is correlated with increased methylation of histone H3 at lysine 9 and decreased methylation at lysine 4 relative to the upstream p15 gene promoter.	Lysine	93-99	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-19
14654786-7	2003	Silencing of CDKN2A in Tu159 cells is correlated with increased methylation of histone H3 at lysine 9 and decreased methylation at lysine 4 relative to the upstream p15 gene promoter.	Lysine	131-137	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-19
12890648-6	2003	PT cells accumulated 109Cd7MT-1 in membrane vesicles associated with the late endo/lysosomal marker LAMP1 but less with the early endosomal marker Rab5a, which was abolished by chloroquine or LY-294002.	Lysine	192-194	RAB5A, member RAS oncogene family	Rattus norvegicus	147-152
12949144-7	2003	In both species, the isopeptide bond is formed between lysine 118 of the actin and the C-terminal glycine 76 of ubiquitin.	Lysine	55-61	Actin 79B	Drosophila melanogaster	73-78
14645664-4	2003	In particular, PKD had lower affinity than PKC for certain diacylglycerol analogs, which might be caused by a lysine residue at the 22 position of the PKD-C1b domain in place of the tryptophan residue at this position conserved in the PKCs.	Lysine	110-116	protein kinase C alpha	Homo sapiens	43-46
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Lysine	196-199	bone gamma-carboxyglutamate protein	Rattus norvegicus	142-153
14623192-8	2003	Analytical ultracentrifugation and lysine-specific cross-linking analysis of the apoE CT domain revealed predominant formation of dimeric and tetrameric species in aqueous buffers, and monomeric forms in 50% TFE.	Lysine	35-41	apolipoprotein E	Homo sapiens	81-85
14568189-8	2003	The activity of PKC and [Ca(2+)]i induced by CD40L were measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich histone and flow cytometric analysis loading with the Ca(2+) dye fluo3/Am, respectively.	Lysine	125-131	CD40 ligand	Homo sapiens	45-50
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	myeloperoxidase	Homo sapiens	17-20
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	tumor necrosis factor	Homo sapiens	63-66
12768249-7	2003	In addition, the micelle interaction domain is located on the front surface of Cyt-c, which includes a ring-like arrangement of lysine residues appropriate for binding one micelle.	Lysine	128-134	cytochrome c, somatic	Homo sapiens	79-84
14627807-0	2003	Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptor.	Lysine	37-43	androgen receptor	Homo sapiens	83-100
12941945-6	2003	However, mutants lacking the SUMO-specific isopeptidase Ulp2 accumulated high molecular weight SUMO-containing species, which formed only when the N-terminal lysines of SUMO were present, suggesting that they contained SUMO chains.	Lysine	158-165	SUMO protease ULP2	Saccharomyces cerevisiae S288C	56-60
14624621-9	2003	Using modifications of this synthetic strategy, the ri-PTD-4-G conjugate of bcl-2 antisense PNA was prepared using a lysine derivative of tetramethylrhodamine (TMR) for fluorescence microscopy.	Lysine	117-123	BCL2 apoptosis regulator	Homo sapiens	76-81
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Lysine	271-274	bone gamma-carboxyglutamate protein	Rattus norvegicus	142-153
14606683-1	2003	Using a combination of Cohn ethanol fractionation, virus inactivation, glycine and sodium chloride precipitation, and lysine-Sepharose affinity chromatography, a unique and rapid simplified method was developed to obtain highly purified fibrinogen for diagnostic use with both biological (Clauss method) and immunological (Jacobsson method) activity.	Lysine	118-124	fibrinogen beta chain	Homo sapiens	237-247
14560007-7	2003	The assay combines the spatial resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues.	Lysine	236-242	CREB binding protein	Homo sapiens	134-154
14560007-7	2003	The assay combines the spatial resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues.	Lysine	236-242	CREB binding protein	Homo sapiens	156-159
14584818-6	2003	L1-Fc micropatterned on a background of poly-L-lysine resulted in selective growth of the axons on the micropattern, whereas the somata and dendrites were unresponsive.	Lysine	40-53	L1 cell adhesion molecule	Homo sapiens	0-2
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Lysine	164-170	coagulation factor II, thrombin	Homo sapiens	20-28
14604530-4	2003	Comparison of the ternary complex with the yHst2/NAD(+) complex, also reported here, and nascent yHst2 structure also reveals that NAD(+) binding accompanies intramolecular loop rearrangement for more stable NAD(+) and acetyl-lysine binding, and that acetyl-lysine peptide binding induces a trimer-monomer protein transition involving nonconserved Sir2 residues.	Lysine	226-232	histone deacetylase HST2	Saccharomyces cerevisiae S288C	43-48
14604530-4	2003	Comparison of the ternary complex with the yHst2/NAD(+) complex, also reported here, and nascent yHst2 structure also reveals that NAD(+) binding accompanies intramolecular loop rearrangement for more stable NAD(+) and acetyl-lysine binding, and that acetyl-lysine peptide binding induces a trimer-monomer protein transition involving nonconserved Sir2 residues.	Lysine	226-232	histone deacetylase HST2	Saccharomyces cerevisiae S288C	97-102
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Lysine	164-170	coagulation factor II, thrombin	Homo sapiens	109-117
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Lysine	172-175	coagulation factor II, thrombin	Homo sapiens	20-28
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Lysine	172-175	coagulation factor II, thrombin	Homo sapiens	109-117
12964026-2	2003	Here, we show that CREB-binding protein (CBP) interacts with AFX via CH1 region and acetylates it at the three lysine residues (K186, K189, and K408).	Lysine	111-117	CREB binding protein	Homo sapiens	19-39
14583461-7	2003	We provide evidence that p53 influences histone H3 acetylation at lysine 9 (K9) and K14, whereas acetylation of K18 appears to be p53 independent.	Lysine	66-72	tumor protein p53	Homo sapiens	25-28
14523231-4	2003	In one family, we identified a T599 --&gt; A mutation changing an isoleucine into a lysine residue (I200K) within the glycine/serine (GS) domain of BMPR1B, a region involved in phosphorylation of the receptor.	Lysine	84-90	bone morphogenetic protein receptor type 1B	Homo sapiens	148-154
12918066-0	2003	Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors.	Lysine	24-27	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	67-72
12918066-8	2003	Trp-557 and/or Lys-558 were mutated in all 15 metastatic GISTs carrying c-kit mutations but only in a minority of nonmetastatic tumors.	Lysine	15-18	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	72-77
12844488-8	2003	However, the p53 mutation frequency increased with the increased number of the combined genotypes among XPD 312WT (Asp/Asp), XPD 751VT (Lys/Gln or Gln/Gln) or XRCC1 399VT (Arg/Gln or Gln/Gln) (P = 0.01, trend test).	Lysine	136-139	tumor protein p53	Homo sapiens	13-16
14572647-0	2003	The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists.	Lysine	23-26	glucagon	Homo sapiens	38-61
14572647-1	2003	Lysine-288 in the glucagon-like peptide-1 receptor was predicted to be ideally positioned to play a role in hormone binding.	Lysine	0-6	glucagon	Homo sapiens	18-41
14561230-6	2003	Results here are the first to show that the efficacy of ion channel activation is decreased by mutations of AQP1 at conserved residues in the C-terminal domain (aspartate D237 and lysine K243).	Lysine	180-186	aquaporin 1 (Colton blood group)	Homo sapiens	108-112
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Lysine	71-74	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Lysine	87-90	coagulation factor II, thrombin	Homo sapiens	13-21
14517253-4	2003	Loss of Lsh, in Lsh-deficient mice, results in accumulation of di- and tri-methylated histone 3 at lysine 4 (H3-K4me) at pericentromeric DNA and other repetitive sequences.	Lysine	99-105	helicase, lymphoid specific	Mus musculus	8-11
12964026-2	2003	Here, we show that CREB-binding protein (CBP) interacts with AFX via CH1 region and acetylates it at the three lysine residues (K186, K189, and K408).	Lysine	111-117	CREB binding protein	Homo sapiens	41-44
12734197-2	2003	The recent determination of the three-dimensional structures of FAAH and two distantly related bacterial amidase signature enzymes indicates that these enzymes employ an unusual serine-serine-lysine triad for catalysis (Ser-241/Ser-217/Lys-142 in FAAH).	Lysine	192-198	fatty acid amide hydrolase	Homo sapiens	64-68
14508232-4	2003	LPS-induced monocytic tissue factor (mTF) procoagulation was readily offset by poly-L-lysine (PLK), poly-L-arginine (PLR), or poly-L-ornithine (POR) included in single-stage clotting assays.	Lysine	79-92	melanotransferrin	Mus musculus	37-40
12734197-2	2003	The recent determination of the three-dimensional structures of FAAH and two distantly related bacterial amidase signature enzymes indicates that these enzymes employ an unusual serine-serine-lysine triad for catalysis (Ser-241/Ser-217/Lys-142 in FAAH).	Lysine	192-198	fatty acid amide hydrolase	Homo sapiens	247-251
12734197-7	2003	Interestingly, although structural evidence indicates that the impact of Lys-142 on catalysis probably occurs through the bridging Ser-217, the mutation of this latter residue to alanine impaired catalytic activity but left the amide/ester hydrolysis ratios of FAAH intact.	Lysine	73-76	fatty acid amide hydrolase	Homo sapiens	261-265
12734197-8	2003	Collectively, these findings suggest that FAAH possesses a specialized active site structure dedicated to a mechanism for competitive amide and ester hydrolysis where nucleophile attack and leaving group protonation occur in a coordinated manner dependent on Lys-142.	Lysine	259-262	fatty acid amide hydrolase	Homo sapiens	42-46
14522900-11	2003	In addition, we found that p33(ING1b) physically interacts with hSIR2, reverses its ability to induce the AFP promoter, and induces acetylation of p53 residues at Lys(373) and/or Lys(382).	Lysine	163-166	tumor protein p53	Homo sapiens	147-150
12974624-7	2003	The crystal structure suggests that a buried Lys(267) is transiently protonated during formyl transfer allowing for the stabilization of the oxyanion transition state and subsequent protonation of N10 on the tetrahydrofolate leaving group.	Lysine	45-48	nuclear receptor subfamily 4 group A member 1	Homo sapiens	197-200
12826664-1	2003	Association of the highly conserved heterochromatin protein, HP1, with the specialized chromatin of centromeres and telomeres requires binding to a specific histone H3 modification of methylation on lysine 9.	Lysine	199-205	Suppressor of variegation 205	Drosophila melanogaster	61-64
12970748-4	2003	Stable transfection of parental MCF-7 cells with a dominant-negative Akt mutant, as well as the PI 3-K inhibitors wortmannin and LY 294,002, blocked the effect of estradiol on ER-alpha expression and activity by 70-80 and 55-63%, respectively.	Lysine	129-131	estrogen receptor 1	Homo sapiens	176-184
12876294-1	2003	Monoubiquitination of histone H2B, catalyzed by Rad6-Bre1, is required for methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively.	Lysine	104-111	ring finger protein 20	Homo sapiens	53-57
12876294-1	2003	Monoubiquitination of histone H2B, catalyzed by Rad6-Bre1, is required for methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively.	Lysine	104-111	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	139-143
12876294-1	2003	Monoubiquitination of histone H2B, catalyzed by Rad6-Bre1, is required for methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively.	Lysine	104-111	DOT1 like histone lysine methyltransferase	Homo sapiens	175-180
12948639-0	2003	Identification and characterization of the last two unknown genes, dapC and dapF, in the succinylase branch of the L-lysine biosynthesis of Corynebacterium glutamicum.	Lysine	115-123	diaminopimelate epimerase	Corynebacterium glutamicum ATCC 13032	76-80
12948639-1	2003	The inspection of the complete genome sequence of Corynebacterium glutamicum ATCC 13032 led to the identification of dapC and dapF, the last two unknown genes of the succinylase branch of the L-lysine biosynthesis.	Lysine	192-200	diaminopimelate epimerase	Corynebacterium glutamicum ATCC 13032	126-130
12948639-9	2003	Overexpression of the dapF or the dapC gene in an industrial C. glutamicum strain resulted in an increased L-lysine production, indicating that both genes might be relevant targets for the development of improved production strains.	Lysine	107-115	diaminopimelate epimerase	Corynebacterium glutamicum ATCC 13032	22-26
12941761-2	2003	We assessed the signaling properties and mitogenic potency of two novel rapid-acting insulin analogs, Lys(B3),Glu(B29) insulin (HMR 1964) and Lys(B3),Ile(B28) insulin (HMR 1153) using myoblasts and cardiomyocytes.	Lysine	102-105	insulin	Homo sapiens	85-92
14686874-12	2003	The SNP detected at base pair 691 would encode for lysine or glutamine at amino acid 231 of LMW-uPA.	Lysine	51-57	plasminogen activator, urokinase	Homo sapiens	92-99
12923058-2	2003	Although DNA-binding sites have been defined for the uninterrupted WT1 zinc finger domains, the most prevalent isoforms of both WT1 and EWS-WT1 have an insertion of three amino acids [lysine, threonine, and serine (KTS)], which abrogates binding to known consensus sequences and transactivation of known target genes.	Lysine	184-190	WT1 transcription factor	Homo sapiens	128-131
12923058-2	2003	Although DNA-binding sites have been defined for the uninterrupted WT1 zinc finger domains, the most prevalent isoforms of both WT1 and EWS-WT1 have an insertion of three amino acids [lysine, threonine, and serine (KTS)], which abrogates binding to known consensus sequences and transactivation of known target genes.	Lysine	184-190	WT1 transcription factor	Homo sapiens	136-143
12919321-8	2003	It has been shown that these agents modify Arg, Lys and Trp residues of the apoB protein of LDL, with the extent of modification induced by the two aldehydes being more rapid than with glucose.	Lysine	48-51	apolipoprotein B	Homo sapiens	76-80
12908887-7	2003	Isoleucine, leucine, valine and lysine were the EAA with the greatest partitioning towards the mammary gland (up to 36 % of the whole-body flux), which could reflect a potentially limiting effect on milk protein synthesis.	Lysine	32-38	Weaning weight-maternal milk	Bos taurus	199-203
12920522-5	2003	Both subunits are acetylated at multiple lysine residues with the p300/CBP acetyltransferases playing a major role in this process in vivo.	Lysine	41-47	CREB binding protein	Homo sapiens	71-74
12920522-6	2003	Further, the acetylation of different lysines regulates different functions of NF-kappaB, including transcriptional activation, DNA binding affinity, IkappaBalpha assembly, and subcellular localization.	Lysine	38-45	nuclear factor kappa B subunit 1	Homo sapiens	79-88
12920522-6	2003	Further, the acetylation of different lysines regulates different functions of NF-kappaB, including transcriptional activation, DNA binding affinity, IkappaBalpha assembly, and subcellular localization.	Lysine	38-45	NFKB inhibitor alpha	Homo sapiens	150-162
12949372-6	2003	Using the breakpoint of a one-slope broken-line model, the lysine requirement was determined to be 4.88 +/- 0.96 g/kg of diet or 366 +/- 72 mg x hen(-1) x d(-1) with an upper 95% CI of 6.40 g/kg of diet or 480 mg x hen(-1) x d(-1).	Lysine	59-65	nescient helix-loop-helix 1	Homo sapiens	145-151
12766171-11	2003	Indeed, the transplanted lysyl-tRNA synthetase succeeds in suppressing a missense Lys --&gt; Asp mutation inserted into the beta-lactamase gene.	Lysine	82-85	lysyl-tRNA synthetase 1	Homo sapiens	25-46
12788913-3	2003	The synthesis of deoxyhypusine catalyzed by this enzyme involves transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in the eIF5A precursor protein to form a deoxyhypusine-containing eIF5A intermediate, eIF5A(Dhp).	Lysine	129-135	dihydropyrimidinase	Homo sapiens	236-239
12917624-5	2003	SUV39H1 methylates lysine 9 of the histone protein H3 leading to the formation of the high-affinity binding site on chromatin for proteins of the heterochromatin protein 1 family (HP1).	Lysine	19-25	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
12907337-8	2003	Staining of the biotinylated 31-43 A-gliadin peptide in the same area of tissue transglutaminase suggested the presence of lysine-donor substrates in intestinal mucosa.	Lysine	123-129	transglutaminase 2	Homo sapiens	73-96
12874219-5	2003	In these studies we mutated Arg(578) and Lys(579) of P2X(7), and the expression profile, channel activity, and pore formation of the mutant were characterized in transfected human embryonic kidney 293 cells.	Lysine	41-44	purinergic receptor P2X 7	Homo sapiens	53-59
12897054-3	2003	In Drosophila S2 cells, and on polytene chromosomes, methyl-Lys 27 and Pc are both excluded from areas that are enriched in methyl-Lys 9 and HP1.	Lysine	60-63	Suppressor of variegation 205	Drosophila melanogaster	141-144
12874219-3	2003	This domain is homologous to the LPS binding region of the LPS binding protein, and we demonstrated that two basic residues (Arg(578), Lys(579)) within this motif are essential for LPS binding to P2X(7) in vitro.	Lysine	135-138	purinergic receptor P2X 7	Homo sapiens	196-202
12874227-8	2003	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.	Lysine	38-41	killer cell lectin-like receptor, subfamily D, member 1	Mus musculus	80-84
12890027-5	2003	The increase of Int protein synthesis also takes place when the rare arginine codons AGA and AGG at positions 3 and 4 are changed to common arginine CGT or lysine AAA codons but not to rare isoleucine ATA codons.	Lysine	156-162	hypothetical protein	Escherichia coli	16-19
12869638-8	2003	Substitution of arginine for all eight lysines of p12 almost abolished its ubiquitination.	Lysine	39-46	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	50-53
12869638-9	2003	Any single lysine or lysine pair was sufficient for p12 ubiquitination.	Lysine	11-17	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	52-55
12869638-9	2003	Any single lysine or lysine pair was sufficient for p12 ubiquitination.	Lysine	21-27	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	52-55
12724314-0	2003	Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.	Lysine	83-89	tumor protein p53	Homo sapiens	61-64
12867029-0	2003	Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin.	Lysine	27-33	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-6
12734181-2	2003	The binding of CaM is mediated in part by the electrostatic interaction between residues Arg-464 and Lys-467 of SK2 and Glu-84 and Glu-87 of CaM.	Lysine	101-104	calmodulin 3	Homo sapiens	15-18
14536086-4	2003	Although recombinant ESET can methylate lysine 9 of histone H3 (H3-K9), its activity is severely compromised when compared to that of the ESET/mAM complex.	Lysine	40-46	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	21-25
12730231-9	2003	Removal of the carboxyl-terminal lysines from the S100A10 subunit attenuated t-PA and plasminogen binding to AIIt.	Lysine	33-40	S100 calcium binding protein A10	Homo sapiens	50-57
12724314-9	2003	Thus, p300 may further regulate the transcriptional activity of p53 through a novel acetylation site, Lys-305.	Lysine	102-105	tumor protein p53	Homo sapiens	64-67
12730231-9	2003	Removal of the carboxyl-terminal lysines from the S100A10 subunit attenuated t-PA and plasminogen binding to AIIt.	Lysine	33-40	plasminogen activator, tissue type	Homo sapiens	77-81
12730231-10	2003	These results show that the carboxyl-terminal lysines of S100A10 form t-PA and plasminogen-binding sites.	Lysine	46-53	S100 calcium binding protein A10	Homo sapiens	57-64
12730231-10	2003	These results show that the carboxyl-terminal lysines of S100A10 form t-PA and plasminogen-binding sites.	Lysine	46-53	plasminogen activator, tissue type	Homo sapiens	70-74
12726776-5	2003	Another is its intrinsic and associated enzymatic activity, which transfers an acetyl-base to the epsilon ( epsilon ) portion of lysine-residues in histones and certain nuclear proteins (factor acetyltransferases; FATs), such as p53, lymphoid enhancer-binding factor (LEF), and transcription factor IIE (TFIIE), which often results in increased transcriptional activity.	Lysine	129-135	tumor protein p53	Homo sapiens	229-232
12716906-3	2003	The application of a laminar flow (12 dyn/cm2) increased the deacetylation at Lys-320 and Lys-373 of p53 and the acetylation at Lys-382 in human umbilical vein endothelial cells.	Lysine	78-81	tumor protein p53	Homo sapiens	101-104
12716906-3	2003	The application of a laminar flow (12 dyn/cm2) increased the deacetylation at Lys-320 and Lys-373 of p53 and the acetylation at Lys-382 in human umbilical vein endothelial cells.	Lysine	90-93	tumor protein p53	Homo sapiens	101-104
12716906-3	2003	The application of a laminar flow (12 dyn/cm2) increased the deacetylation at Lys-320 and Lys-373 of p53 and the acetylation at Lys-382 in human umbilical vein endothelial cells.	Lysine	90-93	tumor protein p53	Homo sapiens	101-104
12716906-5	2003	Treating human umbilical vein endothelial cells with trichostatin A (TSA), an HDAC inhibitor, abolished the flow-induced p53 deacetylation at Lys-320 and Lys-373.	Lysine	142-145	tumor protein p53	Homo sapiens	121-124
12862420-7	2003	To mask the platelet-binding site of FN, PEG-propyl moieties (5000 Da) were covalently appended to lysine residues on the surface of FN, generating FNPEG-5K.	Lysine	99-105	fibronectin 1	Homo sapiens	133-135
12852836-4	2003	The activity of PKC and [Ca2+]i induced by CD40 ligand (CD40L) in PBMC were measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich histone and flow cytometric analysis loading with the Ca2+ dye Fluo-3/Am, respectively.	Lysine	145-151	CD40 ligand	Homo sapiens	43-54
12852836-4	2003	The activity of PKC and [Ca2+]i induced by CD40 ligand (CD40L) in PBMC were measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich histone and flow cytometric analysis loading with the Ca2+ dye Fluo-3/Am, respectively.	Lysine	145-151	CD40 ligand	Homo sapiens	56-61
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-30	plasminogen activator, tissue type	Homo sapiens	156-189
12801297-5	2003	This deletion is located in beta barrel 2 domain of the protein and results in translation of an aberrant FXIIIA molecule that lacks lysine residue either at positions 677 or 678.	Lysine	133-139	coagulation factor XIII A chain	Homo sapiens	106-112
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-30	plasminogen activator, tissue type	Homo sapiens	191-195
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-29	plasminogen activator, tissue type	Homo sapiens	156-189
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-29	plasminogen activator, tissue type	Homo sapiens	191-195
12871292-5	2003	Elimination of these lysines by TAFIa abrogates the fibrin cofactor function of t-PA-mediated plasminogen activation, resulting in a decreased rate of plasmin generation and thus downregulation of fibrinolysis.	Lysine	21-28	plasminogen activator, tissue type	Homo sapiens	80-84
12649291-5	2003	Replacement of Arg204 in ART2b with lysine, tyrosine, or glutamate abolished auto-ADP-ribosylation.	Lysine	36-42	ADP-ribosyltransferase 2b	Rattus norvegicus	25-30
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Lysine	120-126	coagulation factor II, thrombin	Homo sapiens	19-27
12778490-4	2003	For clone K3-2, from a different patient, the substitution of lysine for glutamine or isoleucine for leucine in the core region resulted in about 30-fold and 10-fold increases in the stimulatory capacity of the peptides, respectively.	Lysine	62-68	keratin 32	Homo sapiens	10-14
12663661-3	2003	In the present study, to investigate the mechanisms contributing to the modification of LDL, we analyzed oxidized cholesteryl esters generated during the autoxidation of LDL and characterized their covalent binding to the lysine residues of LDL apoB.	Lysine	222-228	apolipoprotein B	Homo sapiens	245-249
12788812-12	2003	(6) The tachykinin NK(2) receptor-selective agonist [Lys(5)MeLeu(9)Nle(10)]NKA(4-l0) was approximately equipotent with NKA, but the tachykinin NK(1) and NK(3) receptor-selective agonists [Sar(9)Met(O(2))(11)]SP and [MePhe(7)]NKB were ineffective in the myometrium from nonpregnant women.	Lysine	53-56	tachykinin precursor 1	Homo sapiens	75-78
12813029-3	2003	AIP1 binds to the C-terminal domain of ASK1 via a lysine-rich cluster within the N-terminal C2 domain.	Lysine	50-56	DAB2 interacting protein	Homo sapiens	0-4
12875878-13	2003	F15 also showed a high homology with the lysine-rich region of myotoxic PLA(2).	Lysine	41-47	phospholipase A2, group V	Mus musculus	72-77
12637503-0	2003	Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain.	Lysine	145-151	LDL receptor related protein 1	Homo sapiens	55-91
12758070-4	2003	We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13.	Lysine	56-62	CREB binding protein	Homo sapiens	14-17
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	95-101	LDL receptor related protein 1	Homo sapiens	225-228
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	112-115	LDL receptor related protein 1	Homo sapiens	225-228
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	124-127	LDL receptor related protein 1	Homo sapiens	225-228
12637503-6	2003	RAP molecules in which either of these two lysine residues was mutated still bound LRP but with reduced affinity.	Lysine	43-49	LDL receptor related protein 1	Homo sapiens	83-86
12757746-3	2003	This activity was shown to be associated with the proline-lysine-proline motif, which is responsible for the induction of mast cell degranulation by the mammalian bioactive peptide substance P.	Lysine	58-64	tachykinin precursor 1	Homo sapiens	181-192
12642487-3	2003	HP1 associates with centric regions through an interaction with methylated lysine nine of histone H3, a modification generated by the histone methyltransferase SU(VAR)3-9.	Lysine	75-81	Suppressor of variegation 205	Drosophila melanogaster	0-3
12750254-5	2003	p29ING4 and p28ING5 enhance p53 acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and p53 in vivo.	Lysine	47-50	inhibitor of growth family member 5	Homo sapiens	12-19
12750254-5	2003	p29ING4 and p28ING5 enhance p53 acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and p53 in vivo.	Lysine	47-50	tumor protein p53	Homo sapiens	28-31
12750254-5	2003	p29ING4 and p28ING5 enhance p53 acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and p53 in vivo.	Lysine	47-50	tumor protein p53	Homo sapiens	154-157
12875689-7	2003	CONCLUSIONS: Apo(a) induces SMCs growth by inhibiting the activation of latent TGF-beta(1), an activity that may involve the ability of apo(a) kringle IV-10 to bind lysine.	Lysine	165-171	transforming growth factor beta 1	Homo sapiens	79-90
12665803-0	2003	Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.	Lysine	30-36	tumor necrosis factor	Homo sapiens	47-56
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Lysine	97-103	fibroblast growth factor 1	Homo sapiens	35-61
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Lysine	97-103	fibroblast growth factor 1	Homo sapiens	63-68
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Lysine	97-103	coagulation factor II, thrombin	Homo sapiens	119-127
12665803-4	2003	We prepared phage libraries expressing TNF-alpha mutants in which all the lysine residues were replaced with other amino acids.	Lysine	74-80	tumor necrosis factor	Homo sapiens	39-48
12665803-5	2003	A fully bioactive lysine-deficient mutant TNF-alpha (mTNF-alpha-Lys(-)) was isolated by panning against TNF-alpha-neutralizing antibody despite reports that some lysine residues were essential for its bioactivity.	Lysine	18-24	tumor necrosis factor	Homo sapiens	42-51
12665803-5	2003	A fully bioactive lysine-deficient mutant TNF-alpha (mTNF-alpha-Lys(-)) was isolated by panning against TNF-alpha-neutralizing antibody despite reports that some lysine residues were essential for its bioactivity.	Lysine	18-24	tumor necrosis factor	Mus musculus	53-63
12665803-5	2003	A fully bioactive lysine-deficient mutant TNF-alpha (mTNF-alpha-Lys(-)) was isolated by panning against TNF-alpha-neutralizing antibody despite reports that some lysine residues were essential for its bioactivity.	Lysine	18-24	tumor necrosis factor	Homo sapiens	54-63
12665803-5	2003	A fully bioactive lysine-deficient mutant TNF-alpha (mTNF-alpha-Lys(-)) was isolated by panning against TNF-alpha-neutralizing antibody despite reports that some lysine residues were essential for its bioactivity.	Lysine	162-168	tumor necrosis factor	Homo sapiens	42-51
12586828-6	2003	By contrast, Dnmt1 -/- ES cells lack CpG methylation of the PWS-IC but have normal levels of H3 Lys-9 methylation of the PWS-IC and show normal monoallelic Snrpn expression.	Lysine	96-99	DNA methyltransferase (cytosine-5) 1	Mus musculus	13-18
12591926-6	2003	These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation.	Lysine	52-58	tumor necrosis factor	Homo sapiens	120-123
12591926-6	2003	These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation.	Lysine	52-58	mitogen-activated protein kinase 9	Homo sapiens	142-146
12588864-4	2003	Nuclear magnetic resonance measurements showed that, in apoE3-dimyristoyl phosphatidylcholine discs, Lys-143 and -146 in the N-terminal domain and Lys-233 in the C-terminal domain have unusually low pK(a) values, indicating high positive electrostatic potential around these residues.	Lysine	101-104	apolipoprotein E	Homo sapiens	56-61
12588864-6	2003	With lipidated apoE3, it is confirmed that the Lys-233 site is completely masked and the N-terminal site mediates heparin binding.	Lysine	47-50	apolipoprotein E	Homo sapiens	15-20
12588864-9	2003	However, Lys-233 may be involved in the binding of apoE to certain cell-surface sites, such as the protein core of biglycan.	Lysine	9-12	apolipoprotein E	Homo sapiens	51-55
12926382-2	2003	It is now shown that the presence of high exogenous concentrations of all-trans-retinal in photoreceptor outer segments leads to the formation of A2-rhodopsin (A2-Rh), an unprecedented fluorescent rhodopsin adduct which consists of bisretinoids (A2) linked to each of three lysine residues in rhodopsin (Rh) and which exhibits an emission spectrum similar to A2E.	Lysine	274-280	rhodopsin	Homo sapiens	149-158
12926382-2	2003	It is now shown that the presence of high exogenous concentrations of all-trans-retinal in photoreceptor outer segments leads to the formation of A2-rhodopsin (A2-Rh), an unprecedented fluorescent rhodopsin adduct which consists of bisretinoids (A2) linked to each of three lysine residues in rhodopsin (Rh) and which exhibits an emission spectrum similar to A2E.	Lysine	274-280	rhodopsin	Homo sapiens	197-206
12926382-2	2003	It is now shown that the presence of high exogenous concentrations of all-trans-retinal in photoreceptor outer segments leads to the formation of A2-rhodopsin (A2-Rh), an unprecedented fluorescent rhodopsin adduct which consists of bisretinoids (A2) linked to each of three lysine residues in rhodopsin (Rh) and which exhibits an emission spectrum similar to A2E.	Lysine	274-280	rhodopsin	Homo sapiens	197-206
12670868-3	2003	The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated.	Lysine	43-46	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	4-8
12501250-5	2003	Further, p53 trans-activation of the 14-3-3varsigma promoter was markedly repressed by Tat-histone acetyltransferase interactions, and p53 acetylation by p300/CREB-binding protein-associated factor on residue Lys(320) was diminished as a result of Tat-histone acetyltransferase binding in vivo and in vitro.	Lysine	209-212	tumor protein p53	Homo sapiens	9-12
12501250-7	2003	Finally, HIV-1-infected Molt-4 cells displayed reduced p53 acetylation on lysines 320 and 373 in response to UV irradiation.	Lysine	74-81	tumor protein p53	Homo sapiens	55-58
12643708-1	2003	Two novel mono-PEGylated derivatives of hGRF(1-29)-NH(2) [human growth hormone-releasing factor, fragment 1-29] have been synthesized by regio-specific conjugation of Lys(12) or Lys(21) to a monomethoxy-PEG(5000) chain (compounds Lys(12)PEG-GRF and Lys(21)PEG-GRF).	Lysine	167-170	growth hormone releasing hormone	Homo sapiens	64-95
12654817-4	2003	A complementation and sequence analysis revealed that the temperature-sensitive (Ts) phenotype of B-4551 was due to deletion of a lysine residue in the cryptococcal CCN1 gene.	Lysine	130-136	cellular communication network factor 1	Mus musculus	165-169
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Lysine	47-50	plasminogen activator, urokinase	Gallus gallus	34-37
12665567-5	2003	Western blotting and amino-terminal protein sequencing indicated that all lysine residues in the H3 and H4 amino-terminal tails were acetylated by CBP and enhanced by the addition of Zta.	Lysine	74-80	CREB binding protein	Homo sapiens	147-150
12671081-1	2003	To elucidate the relative significance of Lys synthesis and catabolism in determining Lys level in plant seeds, we expressed a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in a seed-specific manner in wild-type Arabidopsis as well as in an Arabidopsis knockout mutant in the Lys catabolism pathway.	Lysine	86-89	dihydrodipicolinate synthase 1	Arabidopsis thaliana	188-192
12671081-1	2003	To elucidate the relative significance of Lys synthesis and catabolism in determining Lys level in plant seeds, we expressed a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in a seed-specific manner in wild-type Arabidopsis as well as in an Arabidopsis knockout mutant in the Lys catabolism pathway.	Lysine	86-89	dihydrodipicolinate synthase 1	Arabidopsis thaliana	188-192
12671081-2	2003	Transgenic plants expressing the bacterial DHPS, or the knockout mutant, contained approximately 12-fold or approximately 5-fold higher levels, respectively, of seed free Lys than wild-type plants.	Lysine	171-174	dihydrodipicolinate synthase 1	Arabidopsis thaliana	43-47
12671081-4	2003	The dramatic increase in free Lys in the knockout mutant expressing the bacterial DHPS was associated with a significant reduction in the levels of Glu and Asp but also with an unexpected increase in the levels of Gln and Asn.	Lysine	30-33	dihydrodipicolinate synthase 1	Arabidopsis thaliana	82-86
12643708-1	2003	Two novel mono-PEGylated derivatives of hGRF(1-29)-NH(2) [human growth hormone-releasing factor, fragment 1-29] have been synthesized by regio-specific conjugation of Lys(12) or Lys(21) to a monomethoxy-PEG(5000) chain (compounds Lys(12)PEG-GRF and Lys(21)PEG-GRF).	Lysine	178-181	growth hormone releasing hormone	Homo sapiens	64-95
12643708-1	2003	Two novel mono-PEGylated derivatives of hGRF(1-29)-NH(2) [human growth hormone-releasing factor, fragment 1-29] have been synthesized by regio-specific conjugation of Lys(12) or Lys(21) to a monomethoxy-PEG(5000) chain (compounds Lys(12)PEG-GRF and Lys(21)PEG-GRF).	Lysine	178-181	growth hormone releasing hormone	Homo sapiens	64-95
12643708-1	2003	Two novel mono-PEGylated derivatives of hGRF(1-29)-NH(2) [human growth hormone-releasing factor, fragment 1-29] have been synthesized by regio-specific conjugation of Lys(12) or Lys(21) to a monomethoxy-PEG(5000) chain (compounds Lys(12)PEG-GRF and Lys(21)PEG-GRF).	Lysine	178-181	growth hormone releasing hormone	Homo sapiens	64-95
12626745-7	2003	TEL is posttranslationally modified by sumoylation at lysine 99 within a highly conserved domain (the "pointed" domain).	Lysine	54-60	ETS variant transcription factor 6	Homo sapiens	0-3
12626745-8	2003	Mutation of the sumo-acceptor lysine or mutations within the pointed domain that affect sumoylation impair nuclear export of TEL.	Lysine	30-36	ETS variant transcription factor 6	Homo sapiens	125-128
12626745-9	2003	Mutation of lysine 99 also results in an increase in TEL transcriptional repression, presumably because of decreased nuclear export.	Lysine	12-18	ETS variant transcription factor 6	Homo sapiens	53-56
12628190-1	2003	Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain.	Lysine	78-84	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
12633731-7	2003	The lysine residue(s) seems to locate closely to reacting residue(s) within apolipoprotein molecules in associates, however, with different package constraints for discoidal versus vesicular complexes with phospholipid.	Lysine	4-10	apolipoprotein E	Homo sapiens	76-90
12818257-0	2003	Comparison between the effects of the rapid recombinant insulin analog Lispro (Lys B28, Pro B29) and those of human regular insulin on platelet cyclic nucleotides and aggregation.	Lysine	79-82	insulin	Homo sapiens	56-63
12522143-8	2003	Competition studies using synthetic peptides suggested that LRP binding involves the FVIII-specific region Lys(1804)-Ala(1834) in the A3 domain.	Lysine	107-110	LDL receptor related protein 1	Homo sapiens	60-63
12522143-9	2003	In line with this observation, LRP binding was inhibited by a recombinant antibody fragment that specifically binds to the FVIII sequence Glu(1811)-Lys(1818).	Lysine	148-151	LDL receptor related protein 1	Homo sapiens	31-34
12522143-10	2003	The role of this sequence in LRP binding was further tested using a FVIII/FV chimera in which sequence Glu(1811)-Lys(1818) was replaced with the corresponding sequence of FV.	Lysine	113-116	LDL receptor related protein 1	Homo sapiens	29-32
12522143-12	2003	This suggests that multiple sites in FVIII contribute to high-affinity LRP binding, one of which is the FVIII A3 domain region Glu(1811)-Lys(1818).	Lysine	137-140	LDL receptor related protein 1	Homo sapiens	71-74
12588512-5	2003	The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT(1A)), LY 53857 (5-HT(2A+2C)), ICS 205-930 (5-HT(3+4)) and RS 23597 (5-HT(4)).	Lysine	134-136	arginine vasopressin	Homo sapiens	28-39
12675602-7	2003	Amino acid analysis of the products of the acid hydrolysis of CPA (both soluble and immobilized) showed that approximately four lysine residues were linked on the glyoxyl agarose beads, suggesting the existence of an intense multipoint covalent attachment between the enzyme and the support.	Lysine	128-134	carboxypeptidase A1	Homo sapiens	62-65
12588512-5	2003	The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT(1A)), LY 53857 (5-HT(2A+2C)), ICS 205-930 (5-HT(3+4)) and RS 23597 (5-HT(4)).	Lysine	134-136	5-hydroxytryptamine receptor 2A	Homo sapiens	144-151
12667454-2	2003	Methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively, is required for silencing of expression of genes located near chromosome telomeres in yeast.	Lysine	29-36	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	100-105
12631734-3	2003	To address this directly, mutant human proinsulin (Arg/Gly(32):Lys/Thr(64)), which cannot be cleaved by conversion endoproteases, was expressed in primary rat islet cells by recombinant adenovirus.	Lysine	63-66	insulin	Homo sapiens	39-49
12667454-3	2003	We report that the Paf1 protein complex, which is associated with the elongating RNA polymerase II, is required for methylation of lysines 4 and 79 of histone H3 and for silencing of expression of a telomere-associated gene.	Lysine	131-138	Paf1p	Saccharomyces cerevisiae S288C	19-23
12573244-2	2003	Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia.	Lysine	90-93	fibrinogen beta chain	Homo sapiens	101-111
12482845-8	2003	We propose that the electrostatic interactions in the first TPR motif made by Lys(8) or Asn(12) define part of the minimum interactions required for successful mSTI1-Hsc70 interaction.	Lysine	78-81	stress-induced phosphoprotein 1	Mus musculus	160-165
12590613-1	2003	Nardilysin (N-arginine dibasic convertase, EC 3.4.24.61) was first identified on the basis of its ability to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys.	Lysine	183-186	nardilysin convertase	Homo sapiens	0-41
12590613-4	2003	Nardilysin cleaves beta-endorphin at the monobasic site, Phe(17)-Lys(18), with a k(cat)/K(m) of 2 x 10(8) M(-)(1) min(-)(1).	Lysine	65-68	nardilysin convertase	Homo sapiens	0-10
12590613-4	2003	Nardilysin cleaves beta-endorphin at the monobasic site, Phe(17)-Lys(18), with a k(cat)/K(m) of 2 x 10(8) M(-)(1) min(-)(1).	Lysine	65-68	proopiomelanocortin	Homo sapiens	19-33
12590613-6	2003	Nardilysin also cleaves calcitonin at His-Arg and somatostatin-14 at Cys-Lys.	Lysine	73-76	nardilysin convertase	Homo sapiens	0-10
12482758-6	2003	AtGC1 contains the arginine or lysine that participates in hydrogen bonding with guanine and the cysteine that confers substrate specificity for GTP.	Lysine	31-37	guanylyl cyclase 1	Arabidopsis thaliana	0-5
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	231-237	myogenic differentiation 1	Homo sapiens	74-78
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	231-237	histone deacetylase 1	Homo sapiens	83-88
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	241-244	myogenic differentiation 1	Homo sapiens	74-78
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	241-244	histone deacetylase 1	Homo sapiens	83-88
12586367-5	2003	Accordingly, we confirm that the effect of E6 and p53 is independent of the six C-terminal lysine residues in p53, which have previously been described to play an important role for effective ubiquitination and degradation of 53 mediated by Mdm2.	Lysine	91-97	tumor protein p53	Homo sapiens	110-113
12574507-1	2003	Methylation of lysine-79 (K79) within the globular domain of histone H3 by Dot1 methylase is important for transcriptional silencing and for association of the Sir silencing proteins in yeast.	Lysine	15-21	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	75-79
12581743-1	2003	Eukaryotic initiation factor 2 (eIF2)-associated glycoprotein, p67, has protection of eIF2alpha phosphorylation (POEP) activity, and this activity requires lysine-rich domains I and II of p67.	Lysine	156-162	CD33 molecule	Homo sapiens	63-66
12581743-1	2003	Eukaryotic initiation factor 2 (eIF2)-associated glycoprotein, p67, has protection of eIF2alpha phosphorylation (POEP) activity, and this activity requires lysine-rich domains I and II of p67.	Lysine	156-162	CD33 molecule	Homo sapiens	188-191
12591902-10	2003	Mutation of the lysine residue within the transmembrane domain of CD158j abolished JNK activation, suggesting that an alternate adaptor molecule was being used.	Lysine	16-22	mitogen-activated protein kinase 8	Homo sapiens	83-86
12427740-4	2003	Here, we show that MeCP2 associates with histone methyltransferase activity in vivo and that this activity is directed against Lys(9) of histone H3.	Lysine	127-130	methyl-CpG binding protein 2	Homo sapiens	19-24
12426309-4	2003	We now identify a second site in A1 at Lys(36) that is cleaved by factor Xa.	Lysine	39-42	BCL2 related protein A1	Homo sapiens	33-35
12427740-6	2003	We asked if MeCP2 can deliver Lys(9) H3 methylation to the H19 gene, whose activity it represses.	Lysine	30-33	methyl-CpG binding protein 2	Homo sapiens	12-17
12397066-6	2003	Addition of a 6x Myc tag to the N terminus of MyoD can force degradation through the lysine-dependent pathway by preventing ubiquitination at the N-terminal site.	Lysine	85-91	myogenic differentiation 1	Homo sapiens	46-50
12446697-6	2003	The results presented here show that the single motor domain of Kar3 (Met(383)-Lys(729)) exhibits characteristics similar to monomeric Ncd.	Lysine	79-82	Kar3p	Saccharomyces cerevisiae S288C	64-68
12446697-6	2003	The results presented here show that the single motor domain of Kar3 (Met(383)-Lys(729)) exhibits characteristics similar to monomeric Ncd.	Lysine	79-82	non-claret disjunctional	Drosophila melanogaster	135-138
12595960-2	2003	In this study we have examined the effects of a novel N/OFQ analogue [Nphe(1),Arg(14),Lys(15)]N/OFQ NH(2) hereafter referred to as UFP-101.	Lysine	86-89	prepronociceptin	Homo sapiens	54-59
12595960-2	2003	In this study we have examined the effects of a novel N/OFQ analogue [Nphe(1),Arg(14),Lys(15)]N/OFQ NH(2) hereafter referred to as UFP-101.	Lysine	86-89	prepronociceptin	Homo sapiens	94-99
12595960-10	2003	When UFP-101 is compared with its template molecule [Nphe(1)]N/OFQ(1-13)NH(2), Arg(14),Lys(15) substitution produced approximately 1 log greater potency.	Lysine	87-90	prepronociceptin	Homo sapiens	61-66
12417586-6	2003	Here we describe the systematic substitution of the 13 lysine or arginine residues located within the general RNA-binding domain of hamster LysRS made of 70 residues.	Lysine	55-61	lysyl-tRNA synthetase 1	Homo sapiens	140-145
14579930-7	2003	(iii) Capsule membranes constructed with a conventional permeability interfered with diffusion of insulin, as illustrated by a lower response of islets in capsules with a 10-min poly-L-lysine (PLL) membrane than islets in capsules with a 5-min PLL membrane.	Lysine	178-191	insulin	Homo sapiens	98-105
14970677-7	2003	In MOGAT1, a missense mutation in exon 4 was found that causes a non-conservative substitution of cysteine170 (uncharged, hydrophobic) by lysine (positively charged, hydrophilic).	Lysine	138-144	monoacylglycerol O-acyltransferase 1	Bos taurus	3-9
12871065-4	2003	Consistent with such a role for uPAR in pericellular proteolysis is the observation that the membrane assembly of both plasminogen, via its lysine binding-sites, and of pro-uPA, via its tight binding to uPAR, is required to favor and confine plasminogen activation potential in proximity of the cell surface.	Lysine	140-146	plasminogen activator, urokinase	Homo sapiens	32-36
12871065-4	2003	Consistent with such a role for uPAR in pericellular proteolysis is the observation that the membrane assembly of both plasminogen, via its lysine binding-sites, and of pro-uPA, via its tight binding to uPAR, is required to favor and confine plasminogen activation potential in proximity of the cell surface.	Lysine	140-146	plasminogen activator, urokinase	Homo sapiens	32-35
12511547-3	2003	Moreover, recent association studies suggested that a G/T polymorphism with an amino acid substitution (Lys/Asn) at codon 198 in exon 5 of the ET-1 gene interacts with body mass index (BMI) in association with blood pressure.	Lysine	104-107	endothelin 1	Homo sapiens	143-147
12535539-4	2003	The RING finger of Bre1 is required for ubiquitination of histone H2B, methylation of lysine 4 and 79 of H3 and for telomeric silencing.	Lysine	86-92	ring finger protein 20	Homo sapiens	19-23
12502858-7	2003	The downregulation of both CD4 and MHC-I was dependent on the presence of lysine residues in their cytoplasmic tails.	Lysine	74-80	CD4 molecule	Homo sapiens	27-30
12482968-5	2003	In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities.	Lysine	155-161	aldo-keto reductase family 1 member B	Homo sapiens	15-22
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	153-156	cyclin dependent kinase inhibitor 2A	Homo sapiens	69-72
12613871-0	2003	Milk production, nutrient utilization, and endocrine responses to increased postruminal lysine and methionine supply in dairy cows.	Lysine	88-94	Weaning weight-maternal milk	Bos taurus	0-4
12643544-2	2003	The enzymes used were trypsin, Lys-C, and Asp-N, which cleave at arginine and lysine residues, lysine, and aspartic acid residues, respectively.	Lysine	78-84	asporin	Homo sapiens	42-47
12643544-2	2003	The enzymes used were trypsin, Lys-C, and Asp-N, which cleave at arginine and lysine residues, lysine, and aspartic acid residues, respectively.	Lysine	95-101	asporin	Homo sapiens	42-47
12576767-11	2003	Decreasing of acceptor activity of tRNA for lysine under experimental myocardial ischemia correlate with increasing of lysyl-tRNA synthetase activity in both studied seasons.	Lysine	44-50	lysine--tRNA ligase	Oryctolagus cuniculus	119-140
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	206-209	cyclin dependent kinase inhibitor 2A	Homo sapiens	69-72
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Lysine	165-171	CREB binding protein	Homo sapiens	4-7
12493838-2	2003	The replacement of a solvent-exposed lysine residue with glycine (Lys8Gly) in a helix of recombinant cytochrome c does not perturb the native structure, but it entropically potentiates main-chain flexibility and thus can promote local distortional motions and large-scale unfolding.	Lysine	37-43	cytochrome c, somatic	Homo sapiens	101-113
12493840-5	2003	Recently, the authors have shown that K191, K268, and K331, out of the 26 lysines present in glyceraldehyde-3-phosphate-dehydrogenase, are the reactive amine-donor sites forming cross-links with substance P, which bears the simplest Q(n) domain (n = 2).	Lysine	74-81	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	93-133
15526500-4	2003	The natural sequence in human insulin at this position is proline at B28 and lysine at B29.	Lysine	77-83	insulin	Homo sapiens	30-37
12421820-2	2002	Interestingly, both acetylation and ubiquitination can modify the same lysine residues at the C terminus of p53, implicating a role of acetylation in the regulation of p53 stability.	Lysine	71-77	tumor protein p53	Homo sapiens	108-111
12421820-2	2002	Interestingly, both acetylation and ubiquitination can modify the same lysine residues at the C terminus of p53, implicating a role of acetylation in the regulation of p53 stability.	Lysine	71-77	tumor protein p53	Homo sapiens	168-171
12559130-0	2003	Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists.	Lysine	0-6	vasoactive intestinal peptide receptor 1	Homo sapiens	68-82
12559130-1	2003	The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamine or of aspartate 196 by asparagine reduced the agonists" ability to stimulate adenylate cyclase activity; VIP behaved like a partial agonist and a partial agonist behaved as an antagonist.	Lysine	89-95	vasoactive intestinal peptide receptor 1	Homo sapiens	164-180
12374802-5	2002	The single lysine residue target for acetylation, lysine 92, is located in the DNA-binding domain and is conserved throughout the entire IRF family.	Lysine	11-17	tripartite motif containing 63	Homo sapiens	137-140
12374802-5	2002	The single lysine residue target for acetylation, lysine 92, is located in the DNA-binding domain and is conserved throughout the entire IRF family.	Lysine	50-56	tripartite motif containing 63	Homo sapiens	137-140
12374802-7	2002	However, a mutant that cannot be acetylated by PCAF due to a change in the surrounding amino acid context of lysine 92 showed increased DNA binding and activity compared with wild type IRF7.	Lysine	109-115	interferon regulatory factor 7	Homo sapiens	185-189
12486002-8	2002	Thus, differential lysine acetylation of Tat coordinates the interactions with its co-activators, cyclin T1 and PCAF.	Lysine	19-25	cyclin T1	Homo sapiens	98-107
12374802-9	2002	Together, our results strongly suggest that acetylation of lysine 92 negatively modulates IRF7 DNA binding.	Lysine	59-65	interferon regulatory factor 7	Homo sapiens	90-94
12377763-5	2002	Grafting the alpha(M)(Lys(245)-Arg(261)) sequence converted alpha(L)beta(2) into a fibrinogen-binding protein capable of mediating efficient and specific adhesion similar to that of wild-type alpha(M)beta(2).	Lysine	22-25	fibrinogen beta chain	Homo sapiens	83-93
12151603-4	2002	Recently, one mechanism of HP1 chromosome association was revealed; the amino-terminal chromo domain of HP1 interacts with methylated lysine nine of histone H3, consistent with the histone code hypothesis.	Lysine	134-140	Suppressor of variegation 205	Drosophila melanogaster	27-30
12151603-4	2002	Recently, one mechanism of HP1 chromosome association was revealed; the amino-terminal chromo domain of HP1 interacts with methylated lysine nine of histone H3, consistent with the histone code hypothesis.	Lysine	134-140	Suppressor of variegation 205	Drosophila melanogaster	104-107
12456660-2	2002	We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 310 for modification.	Lysine	136-143	CREB binding protein	Homo sapiens	37-40
12450380-4	2002	Two lysine residues, Lys 206 and Lys 296, which form a hydrogen-bonded dilysine pair in human Tf, have been shown to strongly influence iron release from the N-lobe.	Lysine	4-10	transferrin	Homo sapiens	94-96
12450380-4	2002	Two lysine residues, Lys 206 and Lys 296, which form a hydrogen-bonded dilysine pair in human Tf, have been shown to strongly influence iron release from the N-lobe.	Lysine	21-24	transferrin	Homo sapiens	94-96
12450380-4	2002	Two lysine residues, Lys 206 and Lys 296, which form a hydrogen-bonded dilysine pair in human Tf, have been shown to strongly influence iron release from the N-lobe.	Lysine	33-36	transferrin	Homo sapiens	94-96
12450380-8	2002	In each of the mutants, however, Lys 301 (equivalent to Lys 296 in Tf) changes its conformation to fill the space occupied by Arg 210 Neta2 in wild-type Lf(N), interacting with the two tyrosine ligands Tyr 92 and Tyr 192.	Lysine	33-36	transferrin	Homo sapiens	67-69
12450380-8	2002	In each of the mutants, however, Lys 301 (equivalent to Lys 296 in Tf) changes its conformation to fill the space occupied by Arg 210 Neta2 in wild-type Lf(N), interacting with the two tyrosine ligands Tyr 92 and Tyr 192.	Lysine	56-59	transferrin	Homo sapiens	67-69
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	64-67	transferrin	Homo sapiens	32-34
12452668-8	2002	It is suggested that the difference in the numbers of lysine residues targeted by GTGase and MTGase may be responsible for the difference in the polymerization process of alpha-lactalbumin between GTGase- and MTGase-catalyzed systems.	Lysine	54-60	lactalbumin alpha	Homo sapiens	171-188
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	64-67	transferrin	Homo sapiens	87-89
12491007-4	2002	We found that the level of Lys(+) reversion was increased in all MMR mutants, with the strongest effect observed in a MSH2 (MUTS homologue)-deprived strain.	Lysine	27-30	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	118-122
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	64-67	transferrin	Homo sapiens	87-89
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	76-79	transferrin	Homo sapiens	32-34
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	76-79	transferrin	Homo sapiens	87-89
12450380-9	2002	By comparison with other Lf and Tf structures, we conclude that Lys 301 (or Lys 296 in Tf) only occupies this site when residue 210 (206 in Tf) is nonpositive (neutral as in R210G and R210L or negative as in R210E).	Lysine	76-79	transferrin	Homo sapiens	87-89
12450380-10	2002	Thus, Lys 206 in the Tf dilysine pair is identified as having a depressed pK(a).	Lysine	6-9	transferrin	Homo sapiens	21-23
12489788-5	2002	Previous mutagenesis studies of the human B1 receptor have implicated extracellular domain (EC) IV in conferring this selectivity for des-Arg10 kallidin, by interacting with the N-terminal Lys residue of the peptide.	Lysine	189-192	bradykinin receptor B1	Homo sapiens	42-53
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	Lysine	167-180	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
12477798-6	2002	Mistargeting of the peroxisomal lysine pathway to the cytosol increases the active concentration of aminoadipate semialdehyde, which is no longer contained in the peroxisome and can now activate Lys14p at much lower levels than in wild-type yeasts.	Lysine	32-38	Lys14p	Saccharomyces cerevisiae S288C	195-201
12324470-7	2002	Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding.	Lysine	147-150	fibrinogen beta chain	Homo sapiens	177-187
12395425-10	2002	However, the studies that considered the effect of solvation lower the barrier for the pathway, which utilizes Lys-73 as a general base, thus creating a possibility of multiple mechanisms for the acylation step in the class A beta-lactamases.	Lysine	111-114	amyloid beta precursor protein	Homo sapiens	224-230
22905400-0	2002	Synthesis, conformation and vibrational dynamics of the peptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B.	Lysine	73-76	apolipoprotein B	Homo sapiens	105-121
22905400-1	2002	The collective normal modes of the hexapeptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B (apo B), have been obtained.	Lysine	56-59	apolipoprotein B	Homo sapiens	88-104
22905400-1	2002	The collective normal modes of the hexapeptide -Ser-Cys-Lys-Leu-Asp-Phe-, a fragment of apolipoprotein B (apo B), have been obtained.	Lysine	56-59	apolipoprotein B	Homo sapiens	106-111
12446790-4	2002	TFIIB with the G204D mutation [TFIIB(G204D)] was suppressed by hydrophobic substitutions at lysine 239 of TBP.	Lysine	92-98	general transcription factor IIB	Homo sapiens	0-5
12446790-4	2002	TFIIB with the G204D mutation [TFIIB(G204D)] was suppressed by hydrophobic substitutions at lysine 239 of TBP.	Lysine	92-98	general transcription factor IIB	Homo sapiens	31-36
12297497-5	2002	Cleavage of Lys(77)-Lys(78) dibasic site in CgA(1-115) was relatively rapid and associated with an increase of pro-adhesive effect.	Lysine	12-15	chromogranin A	Homo sapiens	44-47
12297497-5	2002	Cleavage of Lys(77)-Lys(78) dibasic site in CgA(1-115) was relatively rapid and associated with an increase of pro-adhesive effect.	Lysine	20-23	chromogranin A	Homo sapiens	44-47
12297498-7	2002	Complex formation results in the attachment of an atypical polyubiquitin chain to BAG-1, in which the individual ubiquitin moieties are linked through lysine 11.	Lysine	151-157	BAG cochaperone 1	Homo sapiens	82-87
12437345-1	2002	We characterized electron transfer (ET) from putidaredoxin (Pdx) to the mutants of cytochrome P450(cam) (P450(cam)), in which one of the residues located on the putative binding site to Pdx, Gln360, was replaced with Glu, Lys, and Leu.	Lysine	222-225	calmodulin 3	Homo sapiens	83-103
12437345-1	2002	We characterized electron transfer (ET) from putidaredoxin (Pdx) to the mutants of cytochrome P450(cam) (P450(cam)), in which one of the residues located on the putative binding site to Pdx, Gln360, was replaced with Glu, Lys, and Leu.	Lysine	222-225	calmodulin 3	Homo sapiens	99-102
12437345-2	2002	The kinetic analysis of the ET reactions from reduced Pdx to ferric P450(cam) (the first ET) and to ferrous oxygenated P450(cam) (the second ET) showed the dissociation constants (K(m)) that were moderately perturbed for the Lys and Leu mutants and the distinctly increased for the Glu mutant.	Lysine	225-228	calmodulin 3	Homo sapiens	61-77
12202476-6	2002	Mutagenesis of residues that surround Lys-54 and Lys-99 and demonstration of mannose phosphorylation of a glycosylated derivative of green fluorescent protein provide strong evidence that the cathepsin L phosphorylation signal is a simple structure composed of as few as two well placed lysine residues.	Lysine	38-41	cathepsin L	Homo sapiens	192-203
12437345-2	2002	The kinetic analysis of the ET reactions from reduced Pdx to ferric P450(cam) (the first ET) and to ferrous oxygenated P450(cam) (the second ET) showed the dissociation constants (K(m)) that were moderately perturbed for the Lys and Leu mutants and the distinctly increased for the Glu mutant.	Lysine	225-228	calmodulin 3	Homo sapiens	68-77
12426395-4	2002	The HDAC1 complex binds MDM2 in a p53-independent manner and deacetylates p53 at all known acetylated lysines in vivo.	Lysine	102-109	histone deacetylase 1	Homo sapiens	4-9
12426395-4	2002	The HDAC1 complex binds MDM2 in a p53-independent manner and deacetylates p53 at all known acetylated lysines in vivo.	Lysine	102-109	tumor protein p53	Homo sapiens	74-77
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	tumor protein p53	Homo sapiens	18-21
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	tumor protein p53	Homo sapiens	128-131
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	tumor protein p53	Homo sapiens	128-131
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	histone deacetylase 1	Homo sapiens	238-243
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	tumor protein p53	Homo sapiens	128-131
12485860-3	2002	Due to a charge reversal and clustering of three lysines in the exposed tip region of LK-805, we assumed that additional ionic interactions between the positively charged TNF analog and the negatively charged components of the cell surface were created, which might contribute to improved properties of LK-805.	Lysine	49-56	tumor necrosis factor	Mus musculus	171-174
12186871-3	2002	We replaced three charged amino acids, Lys(332), His(335), and Asp(336), predicted to be in the sixth transmembrane (TM6) helix of MRP1 with neutral and oppositely charged amino acids and determined the effect on substrate specificity and transport activity.	Lysine	39-42	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	145-148	N-myristoyltransferase 1	Homo sapiens	61-65
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	145-148	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	153-156	N-myristoyltransferase 1	Homo sapiens	61-65
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	153-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	153-156	N-myristoyltransferase 1	Homo sapiens	61-65
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Lysine	153-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Lysine	109-112	N-myristoyltransferase 1	Homo sapiens	244-248
12485916-0	2002	Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells.	Lysine	95-101	tumor necrosis factor	Homo sapiens	51-60
12186871-11	2002	The importance of Lys(332) and His(335) in determining substrate specificity and of Asp(336) in overall transport activity suggests that such interactions are critical for the binding and transport of LTC(4) and other substrates of MRP1.	Lysine	18-21	ATP binding cassette subfamily C member 1	Homo sapiens	232-236
12202476-6	2002	Mutagenesis of residues that surround Lys-54 and Lys-99 and demonstration of mannose phosphorylation of a glycosylated derivative of green fluorescent protein provide strong evidence that the cathepsin L phosphorylation signal is a simple structure composed of as few as two well placed lysine residues.	Lysine	49-52	cathepsin L	Homo sapiens	192-203
12202476-6	2002	Mutagenesis of residues that surround Lys-54 and Lys-99 and demonstration of mannose phosphorylation of a glycosylated derivative of green fluorescent protein provide strong evidence that the cathepsin L phosphorylation signal is a simple structure composed of as few as two well placed lysine residues.	Lysine	287-293	cathepsin L	Homo sapiens	192-203
12379744-2	2002	One such modification, methylated histone H3 at lysine-4 (H3-meK4), colocalizes with hyperacetylated histones H3 and H4 in mammalian chromatin.	Lysine	48-54	mitogen-activated protein kinase kinase 4	Homo sapiens	61-65
12379220-4	2002	The predicted full-length Drosophila rpL22 protein has an N-terminal extension rich in alanine, lysine, and proline that appears to be unique to Drosophila.	Lysine	96-102	Ribosomal protein L22	Drosophila melanogaster	37-42
12181318-3	2002	Here we report the mutation of Ser(214) in thrombin to Ala, Thr, Cys, Asp, Glu, and Lys.	Lysine	84-87	coagulation factor II, thrombin	Homo sapiens	43-51
12391296-1	2002	Histone acetyltransferases (HATs) use acetyl CoA to acetylate target lysine residues within histones and other transcription factors, such as the p53 tumor suppressor, to promote gene activation.	Lysine	69-75	tumor protein p53	Homo sapiens	146-149
12177057-1	2002	The visual pigment rhodopsin is characterized by an 11-cis retinal chromophore bound to Lys-296 via a protonated Schiff base.	Lysine	88-91	rhodopsin	Homo sapiens	19-28
12356736-3	2002	SUMO modification of Sp3 occurs at a single lysine located between the second glutamine-rich activation domain and the DNA-binding domain.	Lysine	44-50	Sp3 transcription factor	Homo sapiens	21-24
12095415-1	2002	Nardilysin (N-arginine dibasic convertase, or NRDc) is a cytosolic and cell-surface metalloendopeptidase that, in vitro, cleaves substrates upstream of Arg or Lys in basic pairs.	Lysine	159-162	nardilysin convertase	Homo sapiens	0-41
12095415-1	2002	Nardilysin (N-arginine dibasic convertase, or NRDc) is a cytosolic and cell-surface metalloendopeptidase that, in vitro, cleaves substrates upstream of Arg or Lys in basic pairs.	Lysine	159-162	nardilysin convertase	Homo sapiens	46-50
12154089-3	2002	Primarily because of the recent discovery of the SET domain-depending H3-specific histone methyltransferases SUV39H1 and Suv39h1, which selectively methylate lysine 9 of the H3 N terminus, this posttranslational modification has regained scientific interest.	Lysine	158-164	SUV39H1 histone lysine methyltransferase	Homo sapiens	109-116
12154089-3	2002	Primarily because of the recent discovery of the SET domain-depending H3-specific histone methyltransferases SUV39H1 and Suv39h1, which selectively methylate lysine 9 of the H3 N terminus, this posttranslational modification has regained scientific interest.	Lysine	158-164	SUV39H1 histone lysine methyltransferase	Homo sapiens	121-128
12161447-9	2002	Importantly, the RDM is similar to the recognition sequence for attachment of the ubiquitin-like protein, small ubiquitin-like modifier-1 (SUMO-1), and the conserved lysine residue of each C/EBP RDM served as an attachment site for SUMO-1.	Lysine	166-172	CCAAT enhancer binding protein alpha	Homo sapiens	189-194
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18 receptor 1	Homo sapiens	129-140
12232854-5	2002	In fragile X cells, there is a decrease in methylation of histone H3 at lysine 4 with a large increase in methylation at lysine 9, a change that is consistent with the model of FMR1"s switch from euchromatin to heterochromatin in the disease state.	Lysine	72-78	fragile X messenger ribonucleoprotein 1	Homo sapiens	177-181
12232854-5	2002	In fragile X cells, there is a decrease in methylation of histone H3 at lysine 4 with a large increase in methylation at lysine 9, a change that is consistent with the model of FMR1"s switch from euchromatin to heterochromatin in the disease state.	Lysine	121-127	fragile X messenger ribonucleoprotein 1	Homo sapiens	177-181
12379510-4	2002	A specific Pgp blocker, LY 335979, could block this polar transport of [(3)H]prednisolone.	Lysine	24-26	ATP binding cassette subfamily B member 1	Homo sapiens	11-14
12419227-4	2002	Removal of SUMO-1 from Sp3 by mutation of the SUMO acceptor lysines or expression of the SUMO-1 protease SuPr-1 converted Sp3 to a strong activator with a diffuse nuclear localization.	Lysine	60-67	Sp3 transcription factor	Homo sapiens	122-125
12242305-3	2002	Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase.	Lysine	137-144	histone deacetylase 5	Homo sapiens	37-42
12121981-1	2002	At the primary structure level, the 90-kDa heat shock protein (HSP90) is composed of three regions: the N-terminal (Met(1)-Arg(400)), middle (Glu(401)-Lys(615)), and C-terminal (Asp(621)-Asp(732)) regions.	Lysine	151-154	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	63-68
12395946-8	2002	This effect was particularly dramatic for the positively charged side-chains Arg, Lys and His, whose significant enhancement of hydrophobicity in the presence of the cyano column contrasted with their increase in hydrophilicity in the presence of the considerably more hydrophobic C18 stationary phase.	Lysine	82-85	Bardet-Biedl syndrome 9	Homo sapiens	281-284
12167634-0	2002	Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.	Lysine	104-110	DOT1 like histone lysine methyltransferase	Homo sapiens	64-68
12118014-8	2002	The converse double mutant, but neither single mutation alone, introduced into an exon B background (arginine to aspartic acid and cysteine to lysine) was able to restore the NCX1.4 regulatory phenotype.	Lysine	143-149	solute carrier family 8 member A1	Rattus norvegicus	175-179
12167634-1	2002	Dot1 is a non-SET domain protein that methylates histone H3 at lysine 79, a surface-exposed residue that lies within the globular domain.	Lysine	63-69	DOT1 like histone lysine methyltransferase	Homo sapiens	0-4
12220174-0	2002	The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.	Lysine	5-8	endothelin 1	Homo sapiens	33-45
12118014-9	2002	These data demonstrate that aspartic acid 610 and lysine 617 (using the rat NCX1.4 numbering scheme) are critical molecular determinants of the unique Ca(2+) regulatory properties of NCX1.4.	Lysine	50-56	solute carrier family 8 member A1	Rattus norvegicus	183-187
12196481-7	2002	However, the relative decrease in plasma glucagon concentrations during the 10 min after the glucose challenge was reduced in carriers of the Lys allele (10 +/- 3% decrease from baseline in Lys/Lys, 18 +/- 2% in Glu/Lys, and 20 +/- 2% in Glu/Glu; P = 0.01, ANOVA).	Lysine	142-145	glucagon	Homo sapiens	41-49
12105226-7	2002	Mutational analysis of Rab15 indicates that lysine at position 48 (K48Q) is important for the binding of Rab15-GDP to Mss4.	Lysine	44-50	RAB interacting factor	Homo sapiens	118-122
12230932-4	2002	p12 carrying a lysine residue (p12K) at position 88 of its sequence may be rapidly degraded in the cell via proteasome, whereas p12 with an arginine residue (p12R) at the same position is severalfold more stable.	Lysine	15-21	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	0-3
12230932-4	2002	p12 carrying a lysine residue (p12K) at position 88 of its sequence may be rapidly degraded in the cell via proteasome, whereas p12 with an arginine residue (p12R) at the same position is severalfold more stable.	Lysine	15-21	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	31-34
12084729-5	2002	We found that Schizosaccharomyces pombe Csk1, Candida albicans Cak1, and Arabidopsis thaliana Cak1At, like Cak1p, all displayed a preference for cyclin-free cdk substrates, were insensitive to the protein kinase inhibitor 5"-fluorosulfonylbenzoyladenosine (FSBA), and were insensitive to mutation of a highly conserved lysine residue found in the nucleotide binding pocket of all protein kinases.	Lysine	319-325	CDK-activating kinase 1AT	Arabidopsis thaliana	94-100
12207919-3	2002	Here, we detected and sequenced a p67(phox) homolog in Caco-2 almost identical to the neutrophil sequence, except for three nucleotide substitutions, two of which changed lysines 181 and 328 to arginines.	Lysine	171-178	CD33 molecule	Homo sapiens	34-37
12196481-7	2002	However, the relative decrease in plasma glucagon concentrations during the 10 min after the glucose challenge was reduced in carriers of the Lys allele (10 +/- 3% decrease from baseline in Lys/Lys, 18 +/- 2% in Glu/Lys, and 20 +/- 2% in Glu/Glu; P = 0.01, ANOVA).	Lysine	190-193	glucagon	Homo sapiens	41-49
12048190-0	2002	Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.	Lysine	9-15	karyopherin subunit alpha 1	Homo sapiens	97-113
12230559-3	2002	Purified human plasminogen lysine binding site-1 (kringles 1-3) exhibited a similar capacity to inhibit MDA-MB-231 invasion, impair t-PA and cell membrane-mediated plasminogen activation and impair laminin degradation by plasmin.	Lysine	27-33	plasminogen activator, tissue type	Homo sapiens	132-136
12408818-2	2002	Here we present evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in acetylation of Smad7 on two lysine residues in its N terminus.	Lysine	130-136	SMAD family member 7	Homo sapiens	30-35
12408818-2	2002	Here we present evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in acetylation of Smad7 on two lysine residues in its N terminus.	Lysine	130-136	SMAD family member 7	Homo sapiens	117-122
12408818-3	2002	Acetylation or mutation of these lysine residues stabilizes Smad7 and protects it from TGFbeta-induced degradation.	Lysine	33-39	SMAD family member 7	Homo sapiens	60-65
12408818-3	2002	Acetylation or mutation of these lysine residues stabilizes Smad7 and protects it from TGFbeta-induced degradation.	Lysine	33-39	transforming growth factor beta 1	Homo sapiens	87-94
12408818-4	2002	Furthermore, we demonstrate that the acetylated residues in Smad7 also are targeted by ubiquitination and that acetylation of these lysine residues prevents subsequent ubiquitination.	Lysine	132-138	SMAD family member 7	Homo sapiens	60-65
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	67-70	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	151-156
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	Rad2 family nuclease EXO1	Saccharomyces cerevisiae S288C	93-98
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	Rad2 family nuclease EXO1	Saccharomyces cerevisiae S288C	93-98
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	Rad2 family nuclease EXO1	Saccharomyces cerevisiae S288C	93-98
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Lysine	366-372	cannabinoid receptor 1	Homo sapiens	38-41
12060666-5	2002	Likewise, Lys-731 and Lys-788 mutants of GRIP1 have attenuated ability to enhance AR-dependent transcription and fail to synergize with PIASx beta-mediated activation of AR function, indicating that sumoylation modifies the ability of GRIP1 to function as a steroid receptor coactivator.	Lysine	22-25	androgen receptor	Homo sapiens	82-84
12060666-6	2002	The Lys-731 sumoylation site is conserved in SRC-3 and SRC-1, and the NIDs of the latter coactivators harbor one or two additional sites matching with the consensus sites for SUMO-1 attachment, respectively, suggesting a more general role for the modification in the regulation of SRC protein activity.	Lysine	4-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	55-60
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Lysine	0-3	androgen receptor	Homo sapiens	152-169
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Lysine	0-3	androgen receptor	Homo sapiens	171-173
12060666-5	2002	Likewise, Lys-731 and Lys-788 mutants of GRIP1 have attenuated ability to enhance AR-dependent transcription and fail to synergize with PIASx beta-mediated activation of AR function, indicating that sumoylation modifies the ability of GRIP1 to function as a steroid receptor coactivator.	Lysine	10-13	androgen receptor	Homo sapiens	82-84
12166938-11	2002	These studies suggested that the high CB1 affinity of the R,R stereoisomer is due to the ability of the headgroup to form an intramolecular hydrogen bond between the carboxamide oxygen and the headgroup hydroxyl that orients the C2 and C1" methyl groups to have hydrophobic interactions with valine 3.32(196), while the carboxamide oxygen forms a hydrogen bond with lysine 3.28(192) at CB1.	Lysine	366-372	cannabinoid receptor 1	Homo sapiens	386-389
12062854-2	2002	For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid--&gt;glutamic acid) and 420 (threonine--&gt;lysine) may affect genetic susceptibility to T2DM.	Lysine	172-178	D-box binding PAR bZIP transcription factor	Homo sapiens	74-77
12224426-2	2002	alpha-Lactalbumin, usually resistant to tryptic hydrolysis, aggregated after heating at &gt; or = 85 degrees C. After its denaturation, alpha-lactalbumin was susceptible to tryptic hydrolysis probably because of exposure of its previously hidden tryptic cleavage sites (Lys-X and Arg-X bonds).	Lysine	270-273	lactalbumin alpha	Homo sapiens	0-17
12215008-4	2002	WT1 is expressed in 4 isoforms as a result of 2 alternative messenger RNA splicing events, the more significant of which encodes the 3 amino acids lysine, threonine, and serine (KTS) between zinc fingers 3 and 4.	Lysine	147-153	WT1 transcription factor	Homo sapiens	0-3
12224426-2	2002	alpha-Lactalbumin, usually resistant to tryptic hydrolysis, aggregated after heating at &gt; or = 85 degrees C. After its denaturation, alpha-lactalbumin was susceptible to tryptic hydrolysis probably because of exposure of its previously hidden tryptic cleavage sites (Lys-X and Arg-X bonds).	Lysine	270-273	lactalbumin alpha	Homo sapiens	136-153
12127976-0	2002	Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.	Lysine	0-3	phospholipase A2 group IB	Homo sapiens	72-88
12144503-4	2002	Lys-substitution ([K(2, 13)]-CRAMP-18 or [K(9, 16)]-CRAMP-18) in the hydrophilic helix face produced a smaller response.	Lysine	0-3	cathelicidin antimicrobial peptide	Homo sapiens	29-34
12144503-4	2002	Lys-substitution ([K(2, 13)]-CRAMP-18 or [K(9, 16)]-CRAMP-18) in the hydrophilic helix face produced a smaller response.	Lysine	0-3	cathelicidin antimicrobial peptide	Homo sapiens	52-57
12130537-2	2002	In fission yeast, conserved heterochromatin-specific modifications of the histone H3 tail, involving deacetylation of Lys 9 and Lys 14 and subsequent methylation of Lys 9, promote the recruitment of a heterochromatin protein, Swi6, a homolog of the Drosophila heterochromatin protein 1.	Lysine	118-121	Suppressor of variegation 205	Drosophila melanogaster	260-285
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Lysine	39-42	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Lysine	39-42	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127
12130537-2	2002	In fission yeast, conserved heterochromatin-specific modifications of the histone H3 tail, involving deacetylation of Lys 9 and Lys 14 and subsequent methylation of Lys 9, promote the recruitment of a heterochromatin protein, Swi6, a homolog of the Drosophila heterochromatin protein 1.	Lysine	128-131	Suppressor of variegation 205	Drosophila melanogaster	260-285
12130537-2	2002	In fission yeast, conserved heterochromatin-specific modifications of the histone H3 tail, involving deacetylation of Lys 9 and Lys 14 and subsequent methylation of Lys 9, promote the recruitment of a heterochromatin protein, Swi6, a homolog of the Drosophila heterochromatin protein 1.	Lysine	128-131	Suppressor of variegation 205	Drosophila melanogaster	260-285
12095635-5	2002	These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition.	Lysine	75-78	coagulation factor II, thrombin	Homo sapiens	157-165
11973335-4	2002	We show that the CBP-mediated acetylation of beta-catenin occurs at a single site, lysine 49.	Lysine	83-89	CREB binding protein	Homo sapiens	17-20
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	10-17	histone deacetylase 2	Homo sapiens	131-136
12270762-6	2002	RESULTS: There were no sequence abnormalities in LCAT, but we found that he was a heterozygote for a novel APOA1 mutation in codon 107 (AAG-&gt;TGG), which predicted the replacement of lysine by tryptophan (K107W).	Lysine	185-191	apolipoprotein A1	Homo sapiens	107-112
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Lysine	40-46	growth hormone 1	Homo sapiens	76-90
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Lysine	40-46	growth hormone 1	Homo sapiens	92-94
12001173-4	2002	Direct capture of t-PA from cell culture broth was realized by using custom-made affinity membranes with lysine as a robust, small molecular weight affinity ligand.	Lysine	105-111	plasminogen activator, tissue type	Homo sapiens	18-22
11950839-4	2002	Ro106-9920 was observed to inhibit an ubiquitination activity that does not require betaTRCP but associates with IkappaB(alpha) and will ubiquitinate IkappaB(alpha) S32E,S36E (IkappaB(alpha)(ee)) specifically at lysine 21 or 22.	Lysine	212-218	NFKB inhibitor alpha	Homo sapiens	150-164
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	10-17	histone deacetylase 1	Homo sapiens	4-9
12139920-9	2002	Interestingly, there is a noteworthy up-regulation of somatodendritic MAPs such as high-molecular-weight MAP2 and mode II-phosphorylated MAP1B in neurons cultured on stably transfected 3T3 cells overexpressing ephrin-B1 compared with neurons plated on either control 3T3 cells or poly-L-lysine.	Lysine	280-293	ephrin B1	Mus musculus	210-219
11950839-4	2002	Ro106-9920 was observed to inhibit an ubiquitination activity that does not require betaTRCP but associates with IkappaB(alpha) and will ubiquitinate IkappaB(alpha) S32E,S36E (IkappaB(alpha)(ee)) specifically at lysine 21 or 22.	Lysine	212-218	NFKB inhibitor alpha	Homo sapiens	150-164
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	10-17	histone deacetylase 1	Homo sapiens	158-163
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	74-77	histone deacetylase 1	Homo sapiens	4-9
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	74-77	histone deacetylase 2	Homo sapiens	131-136
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	74-77	histone deacetylase 1	Homo sapiens	158-163
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	86-89	histone deacetylase 1	Homo sapiens	4-9
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	86-89	histone deacetylase 2	Homo sapiens	131-136
11960997-5	2002	The HDAC1 lysines targeted for modification were identified as C-terminal Lys-444 and Lys-476, which are also present in mammalian HDAC2 and lower vertebrate HDAC1/2 orthologs yet absent from other HDAC family members, pointing to a means of differential regulation among HDAC proteins.	Lysine	86-89	histone deacetylase 1	Homo sapiens	158-163
11960997-6	2002	Mutation of these target residues (lysine to arginine substitution) profoundly reduced HDAC1-mediated transcriptional repression in reporter assays without affecting HDAC1 ability to associate with mSin3A and eliminated HDAC1-induced cell cycle and apoptotic responses upon overexpression.	Lysine	35-41	histone deacetylase 1	Homo sapiens	87-92
12080090-0	2002	Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.	Lysine	0-6	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	63-67
12052712-2	2002	Electrophilically activated derivatives of low-molecular-weight monomethoxypoly(ethylene glycol) (mPEG) were chemically coupled to insulin via its amino groups at positions phenylalanine-B1 or lysine-B29, with an amide bond being formed between the polymer and protein.	Lysine	193-199	insulin	Homo sapiens	131-138
12080090-4	2002	In the yeast Saccharomyces cerevisiae, Lys 79 of histone H3 is methylated by Dot1, a protein shown previously to play a role in telomeric silencing.	Lysine	39-42	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	77-81
12080090-5	2002	Mutations of Lys 79 of histone H3 and mutations that abolish the catalytic activity of Dot1 impair telomeric silencing, suggesting that Dot1 mediates telomeric silencing largely through methylation of Lys 79.	Lysine	13-16	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	136-140
12080090-5	2002	Mutations of Lys 79 of histone H3 and mutations that abolish the catalytic activity of Dot1 impair telomeric silencing, suggesting that Dot1 mediates telomeric silencing largely through methylation of Lys 79.	Lysine	201-204	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	87-91
12080090-5	2002	Mutations of Lys 79 of histone H3 and mutations that abolish the catalytic activity of Dot1 impair telomeric silencing, suggesting that Dot1 mediates telomeric silencing largely through methylation of Lys 79.	Lysine	201-204	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	136-140
12080090-6	2002	This defect in telomeric silencing might reflect an interaction between Sir proteins and Lys 79, because dot1 and Lys 79 mutations weaken the interaction of Sir2 and Sir3 with the telomeric region in vivo.	Lysine	89-92	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	105-109
11927573-7	2002	Examination of the crystal structure reveals that the NH2-terminal extension in UbcH10 is disordered and that a conserved 3(10)-helix places a lysine residue near the active site.	Lysine	143-149	ubiquitin conjugating enzyme E2 C	Homo sapiens	80-86
12044149-2	2002	It was found that tryptophan-flanked (WALP) peptides and lysine-flanked (KALP) peptides both promote formation of nonlamellar phases in these lipid systems in a mismatch-dependent manner.	Lysine	57-63	anosmin 2, pseudogene	Homo sapiens	73-77
12086673-2	2002	We now find that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of the nucleosome core.	Lysine	48-54	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	17-22
12037013-5	2002	RESULTS: The N-terminal Met-Gly-Cys-X-Phe-Ser-Lys motif of human RP2 is necessary and sufficient for the protein"s plasma membrane localization.	Lysine	46-49	RP2 activator of ARL3 GTPase	Homo sapiens	65-68
12069854-6	2002	The prepared mutant protein proved to be useful as a tool to study the role of Lys-75 in apoE glycation.	Lysine	79-82	apolipoprotein E	Homo sapiens	89-93
12034572-1	2002	Plasma deficiency of alpha(1)-antitrypsin is most commonly due to the Z mutation ((342)Glu--&gt; Lys) and is associated with early-onset panlobular emphysema.	Lysine	97-100	serpin family A member 1	Homo sapiens	21-41
12069856-12	2002	Direct sequencing analysis of her apo E gene confirmed a homozygous one nucleotide change: G to A at nucleotide position of 2836 in the exon 3, resulting in Glu3--&gt;Lys mutation.	Lysine	167-170	apolipoprotein E	Homo sapiens	34-39
11919190-9	2002	However, TGF-beta induced rapid and prolonged lysine acetylation of Ets1.	Lysine	46-52	transforming growth factor beta 1	Homo sapiens	9-17
12050216-8	2002	The aldosterone response of cultured ZG cells to VIP or PACAP was unaffected by the PAC(1) receptor antagonist PACAP-(6-38) (PAC(1)-A), but was significantly decreased by the VPAC(1) receptor antagonist [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP-(3-7),GH-releasing factor-(8-27)-NH(2) (VPAC(1)-A).	Lysine	223-226	vasoactive intestinal peptide	Homo sapiens	49-52
12050205-7	2002	WT1 transcript analysis showed reversal of the normal positive/negative KTS (lysine, threonine, and serine) isoform ratio, confirming the diagnosis of FS.	Lysine	77-83	WT1 transcription factor	Homo sapiens	0-3
12038980-10	2002	Our data strongly suggest that the cloverleaf shape of other metazoan lysine tRNAs should also be stabilized by means of similar strategies to in the case of human tRNA(Lys3).	Lysine	70-76	mitochondrially encoded tRNA glycine	Homo sapiens	164-173
12050216-8	2002	The aldosterone response of cultured ZG cells to VIP or PACAP was unaffected by the PAC(1) receptor antagonist PACAP-(6-38) (PAC(1)-A), but was significantly decreased by the VPAC(1) receptor antagonist [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP-(3-7),GH-releasing factor-(8-27)-NH(2) (VPAC(1)-A).	Lysine	223-226	vasoactive intestinal peptide receptor 1	Homo sapiens	175-191
12050216-8	2002	The aldosterone response of cultured ZG cells to VIP or PACAP was unaffected by the PAC(1) receptor antagonist PACAP-(6-38) (PAC(1)-A), but was significantly decreased by the VPAC(1) receptor antagonist [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP-(3-7),GH-releasing factor-(8-27)-NH(2) (VPAC(1)-A).	Lysine	223-226	vasoactive intestinal peptide receptor 1	Homo sapiens	175-182
11994459-6	2002	Mutations of these lysine residues prevent the binding of PP2AA and enhance the inhibition of IL-2 gene transcription by CTLA-4, indicating that PP2A represses CTLA-4 function.	Lysine	19-25	interleukin 2	Homo sapiens	94-98
12086611-2	2002	Dot1p is a new type of methyltransferase that methylates lysine 79 in the histone H3 core only in its nucleosomal context and has a possible role in marking open chromatin regions.	Lysine	57-63	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
11988071-12	2002	Significant proportions of arginine and lysine-derived AGEs in albumin modified highly by methylglyoxal, and lysine-derived AGEs in albumin modified highly by glucose, remain to be identified.	Lysine	109-115	albumin	Homo sapiens	132-139
11912203-0	2002	Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin.	Lysine	54-60	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-110
11912203-6	2002	The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D).	Lysine	47-54	adiponectin, C1Q and collagen domain containing	Homo sapiens	123-134
11912203-9	2002	Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines.	Lysine	368-375	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
11912203-9	2002	Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines.	Lysine	368-375	insulin	Homo sapiens	208-215
11912203-10	2002	These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.	Lysine	181-188	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
12019170-10	2002	Modeling of p53 interaction with DNA suggests that R283H mutation may weaken the sequence-specific interaction of p53 lysine 120 with the BAX gene but not the CDKN1A p53-responsive elements.	Lysine	118-124	tumor protein p53	Homo sapiens	12-15
12019170-10	2002	Modeling of p53 interaction with DNA suggests that R283H mutation may weaken the sequence-specific interaction of p53 lysine 120 with the BAX gene but not the CDKN1A p53-responsive elements.	Lysine	118-124	tumor protein p53	Homo sapiens	114-117
12019170-10	2002	Modeling of p53 interaction with DNA suggests that R283H mutation may weaken the sequence-specific interaction of p53 lysine 120 with the BAX gene but not the CDKN1A p53-responsive elements.	Lysine	118-124	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
11861638-10	2002	In vitro experiments using furin and purified EC-SOD suggest that furin proteolytically cleaves EC-SOD in the middle of the polybasic region and then requires an additional carboxypeptidase to remove the remaining lysines and arginines.	Lysine	214-221	superoxide dismutase 3	Homo sapiens	46-52
12019170-10	2002	Modeling of p53 interaction with DNA suggests that R283H mutation may weaken the sequence-specific interaction of p53 lysine 120 with the BAX gene but not the CDKN1A p53-responsive elements.	Lysine	118-124	tumor protein p53	Homo sapiens	114-117
11982427-2	2002	Three MRPs, Xyl-Lys MRP, Glu-Lys MRP, and Fru-Lys MRP, were prepared by heating lysine with xylose, glucose, and fructose, respectively, at pH 9.0 and 100 degrees C for 3 h and called undialyzed MRPs.	Lysine	80-86	ATP binding cassette subfamily C member 1	Homo sapiens	6-9
11880373-3	2002	We found that enalaprilat and other ACE inhibitors in nanomolar concentrations activate human bradykinin B(1) receptors directly in the absence of ACE and the B(1) agonist des-Arg(10)-Lys(1)-bradykinin.	Lysine	184-187	angiotensin I converting enzyme	Homo sapiens	36-39
11880373-3	2002	We found that enalaprilat and other ACE inhibitors in nanomolar concentrations activate human bradykinin B(1) receptors directly in the absence of ACE and the B(1) agonist des-Arg(10)-Lys(1)-bradykinin.	Lysine	184-187	kininogen 1	Homo sapiens	94-104
11839747-5	2002	A prominent V-shaped groove formed by a surface loop, L1, connecting beta 1- and beta 2-strands and the lipoyl lysine beta-hairpin constitutes the functional pocket.	Lysine	111-117	L1 cell adhesion molecule	Homo sapiens	54-87
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Lysine	48-54	prolactin induced protein	Homo sapiens	128-131
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Lysine	78-84	prolactin induced protein	Homo sapiens	128-131
11964162-9	2002	Molecular modelling showed how the replacement Lys(111)--&gt;isoleucine in AVR2 alters the shape of the biotin-binding pocket and thus results in reversible binding.	Lysine	47-50	avidin related protein 2	Gallus gallus	75-79
11959547-3	2002	The 876-bp bla(CTX-M-17) gene differed from bla(CTX-M-14) by 2 nucleotides, which led to the single amino acid substitution Glu289--&gt;Lys.	Lysine	136-139	beta-lactamase CTX-M-14	Klebsiella pneumoniae	48-56
12009949-5	2002	Therefore, our data clearly suggests that supramolecular structure in the polyrotaxane conjugates contributes considerably to the inhibitory effect via multivalent binding of Val-Lys groups with hPEPT1.	Lysine	179-182	solute carrier family 15 member 1	Homo sapiens	195-201
11971970-3	2002	The AR is posttranslationally modified on lysine residues by acetylation and sumoylation.	Lysine	42-48	androgen receptor	Homo sapiens	4-6
11971970-12	2002	As AR lysine residue mutations that abrogate acetylation correlate with enhanced binding of the N-CoR repressor in cultured cells, the conserved AR motif may directly or indirectly regulate ligand-dependent corepressor disengagement and, thereby, ligand-dependent trans activation.	Lysine	6-12	androgen receptor	Homo sapiens	3-5
11981030-7	2002	Finally, substitution of lysine residues 302 and 303 of ERalpha for glycine rendered a mutant ERalpha unable to interact with CaM whose transactivation activity became insensitive to W7.	Lysine	25-31	estrogen receptor 1	Homo sapiens	56-63
11939791-2	2002	The interaction of the carboxyl-terminal lysine residues of the p11 subunit of AIIt with the lysine-binding kringle domains of plasminogen is believed to play a key role in plasminogen binding and stimulation of the tPA-catalyzed cleavage of plasminogen to plasmin.	Lysine	41-47	S100 calcium binding protein A10	Homo sapiens	64-67
11981030-7	2002	Finally, substitution of lysine residues 302 and 303 of ERalpha for glycine rendered a mutant ERalpha unable to interact with CaM whose transactivation activity became insensitive to W7.	Lysine	25-31	estrogen receptor 1	Homo sapiens	94-101
11847213-13	2002	Replacement of lysine 74 in rat RAMP1 with tryptophan (the homologous amino acid in the human receptor) resulted in a &gt; or =100-fold increase in antagonist affinities, similar to the K(i) values for the human receptor.	Lysine	15-21	receptor activity modifying protein 1	Rattus norvegicus	32-37
11939791-2	2002	The interaction of the carboxyl-terminal lysine residues of the p11 subunit of AIIt with the lysine-binding kringle domains of plasminogen is believed to play a key role in plasminogen binding and stimulation of the tPA-catalyzed cleavage of plasminogen to plasmin.	Lysine	93-99	S100 calcium binding protein A10	Homo sapiens	64-67
11939791-7	2002	Treatment of AIIt with carboxypeptidase resulted in loss of both carboxyl-terminal lysine residues from the p11 subunit, which correlated with a decrease in the k(cat) and an increase in the K(m) for plasminogen activation.	Lysine	83-89	S100 calcium binding protein A10	Homo sapiens	108-111
12182908-1	2002	The amino terminal fragment (ATF, Ser(1)-Lys(135)) of urokinase-type plasminogen activator (uPA) containing an epidermal growth factor-like (EGF) and kringle domain is critically involved in some important functions of uPA, such as receptor binding and chemotactic activity.	Lysine	41-44	plasminogen activator, urokinase	Homo sapiens	54-90
11925101-3	2002	It previously had been reported, using lysine-721 mutants (K721), that kinase domain function was required for ErbB-mediated cell transformation.	Lysine	39-45	epidermal growth factor receptor	Homo sapiens	111-115
11950211-7	2002	The l-lysine generated from N(epsilon)-(gamma-l-glutamyl)-l-lysine in an endpoint assay is converted to alpha-keto epsilon-aminocaproate semicarbazone in the presence of semicarbazide, excess l-lysine alpha-oxidase, and catalase.	Lysine	4-12	catalase	Rattus norvegicus	194-228
12182908-8	2002	These findings suggested that the inhibitory effects of ATF on sc-uPA activation by Lys-plasmin and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF (by its C-terminal Lys(135) and internal Lys/Arg residue) with the kringle 1-4 of plasmin and plasminogen, respectively.	Lysine	84-87	plasminogen activator, urokinase	Homo sapiens	66-69
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	43-46	tumor protein p53	Homo sapiens	0-3
12182908-8	2002	These findings suggested that the inhibitory effects of ATF on sc-uPA activation by Lys-plasmin and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF (by its C-terminal Lys(135) and internal Lys/Arg residue) with the kringle 1-4 of plasmin and plasminogen, respectively.	Lysine	108-111	plasminogen activator, urokinase	Homo sapiens	141-144
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	43-46	tumor protein p53	Homo sapiens	73-76
11952343-7	2002	The HHPA-adducts were localized to the N-terminal valine of the alpha- and beta-chains of Hb and to lysine residues at positions 7, 11, 16, and 40 of the alpha-chain and 8, 17, 59, 66, and 144 of the beta-chain.	Lysine	100-106	Fc gamma receptor and transporter	Homo sapiens	154-165
11971195-0	2002	Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells.	Lysine	9-15	tumor protein p53	Homo sapiens	47-50
11971195-1	2002	We have recently shown that lysine mutations in p53"s putative C-terminal acetylation sites result in increased stability and cytoplasmic distribution of the p53 protein in a human lung cancer cell line.	Lysine	28-34	tumor protein p53	Homo sapiens	48-51
11971195-1	2002	We have recently shown that lysine mutations in p53"s putative C-terminal acetylation sites result in increased stability and cytoplasmic distribution of the p53 protein in a human lung cancer cell line.	Lysine	28-34	tumor protein p53	Homo sapiens	158-161
11971195-2	2002	In the present study, we showed that when lysine residues 372, 373, 381, and 382 of p53 were substituted with alanine, the resulting A4 protein was resistant to MDM2-mediated proteosomal degradation but was highly sensitive to human papillomavirus E6-mediated proteolysis.	Lysine	42-48	tumor protein p53	Homo sapiens	84-87
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	30-33	tumor protein p53	Homo sapiens	0-3
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	30-33	tumor protein p53	Homo sapiens	73-76
11922623-6	2002	In both pepsinogen and progastricsin a lysine side-chain in the pro-segment forms a salt bridge to the two catalytic aspartates, occupying the position normally occupied by a catalytic water.	Lysine	39-45	progastricsin	Homo sapiens	23-36
12133291-2	2002	METHODS: Human proinsulin cDNA was cloned from its genomic gene and mutated by overlap extension PCR, introducing furin consensus cleavage sequences (Arg-Xaa-Lys/Arg-Arg).	Lysine	158-161	insulin	Homo sapiens	15-25
11866430-0	2002	Poly-L-lysine dissolves fibrillar aggregation of the Alzheimer beta-amyloid peptide in vitro.	Lysine	0-13	amyloid beta precursor protein	Homo sapiens	63-83
11960383-1	2002	Mutation of four lysine residues in the p53 C-terminal domain inhibits MDM2-dependent ubiquitination of p53 and alters its subcellular distribution.	Lysine	17-23	tumor protein p53	Homo sapiens	40-43
11960383-1	2002	Mutation of four lysine residues in the p53 C-terminal domain inhibits MDM2-dependent ubiquitination of p53 and alters its subcellular distribution.	Lysine	17-23	tumor protein p53	Homo sapiens	104-107
11960383-3	2002	In this study, we demonstrated that p53 with lysine residues 372, 373, 381, and 382 mutated to alanine (the A4 mutant) retained the transactivation activity of wild-type p53, although the transactivation activity of p21 promoter by the A4 mutant was slightly reduced.	Lysine	45-51	tumor protein p53	Homo sapiens	36-39
11960383-3	2002	In this study, we demonstrated that p53 with lysine residues 372, 373, 381, and 382 mutated to alanine (the A4 mutant) retained the transactivation activity of wild-type p53, although the transactivation activity of p21 promoter by the A4 mutant was slightly reduced.	Lysine	45-51	tumor protein p53	Homo sapiens	170-173
11960383-3	2002	In this study, we demonstrated that p53 with lysine residues 372, 373, 381, and 382 mutated to alanine (the A4 mutant) retained the transactivation activity of wild-type p53, although the transactivation activity of p21 promoter by the A4 mutant was slightly reduced.	Lysine	45-51	cyclin dependent kinase inhibitor 1A	Homo sapiens	216-219
11777905-2	2002	Complexes shown to contain HDAC1, HDAC3, HDAC6, and HDAC1+2 as their catalytic subunits have been used in an antibody-based assay that detects deacetylation of whole histones at defined lysines.	Lysine	186-193	histone deacetylase 1	Homo sapiens	52-59
11777905-4	2002	In comparison to HDAC1, HDAC3 preferentially deacetylated lysines 5 and 12 of H4 and lysine 5 of H2A.	Lysine	58-65	histone deacetylase 1	Homo sapiens	17-22
11777905-4	2002	In comparison to HDAC1, HDAC3 preferentially deacetylated lysines 5 and 12 of H4 and lysine 5 of H2A.	Lysine	58-64	histone deacetylase 1	Homo sapiens	17-22
11866428-1	2002	The OST48 subunit of the oligosaccharyltransferase complex is a type I membrane protein containing three lysines in its cytosolic domain.	Lysine	105-112	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	4-9
11866428-3	2002	Substitution of these lysines by arginine resulted in cell-surface expression of OST48, whereas ER residency was maintained when either Lys-5 or Lys-3 but not both was replaced with arginine.	Lysine	22-29	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	81-86
11958985-2	2002	From a screen lead, SAR efforts resulted in the preparation of LY 402913 (9h), which inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC(50)=0.90 microM), while showing no inherent cytotoxicity.	Lysine	63-65	ATP binding cassette subfamily C member 1	Homo sapiens	94-98
11958985-2	2002	From a screen lead, SAR efforts resulted in the preparation of LY 402913 (9h), which inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC(50)=0.90 microM), while showing no inherent cytotoxicity.	Lysine	63-65	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
11904408-0	2002	Solution NMR spectroscopy of [alpha -15N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence.	Lysine	156-159	rhodopsin	Homo sapiens	56-65
11904408-2	2002	Whereas rhodopsin contains 11 lysines, 8 in cytoplasmic loops and 1 each in the C-terminal peptide sequence and the intradiscal and transmembrane domains, only a single sharp peak was observed in dodecyl maltoside micelles.	Lysine	30-37	rhodopsin	Homo sapiens	8-17
11904408-7	2002	First, the signal is observed in HNCO spectra of rhodopsin, containing the labeled [(13)C]Ser-338/[(15)N]Lys-339 dipeptide.	Lysine	105-108	rhodopsin	Homo sapiens	49-58
11879917-1	2002	Several cyclic analogues of renin inhibitors, based on Glu-D-Phe-Lys motif have been investigated by NMR spectroscopy and molecular dynamics calculations (MD).	Lysine	65-68	renin	Homo sapiens	28-33
11970735-1	2002	Beta-endorphin and the synthetic beta-endorphin-like decapeptide Ser-Leu-Thr-Cys-Leu-Val-Lys-Gly-Phe-Tyr (referred to as immunorphin), corresponding to the sequence 364-373 of the CH3 domain of human immunoglobulin G heavy chain, were shown to stimulate concanavalin A-induced proliferation of T lymphocytes from the blood of healthy donors.	Lysine	89-92	proopiomelanocortin	Homo sapiens	33-47
11814862-1	2002	A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo(Lys(18)-Asp(22))[Ala(1),Nle(8),Lys(18),Asp(22),Leu(27)]hPTH(1-31)NH(2) (2, EC(50)=0.29nM).	Lysine	115-118	parathyroid hormone	Homo sapiens	53-57
11814862-1	2002	A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo(Lys(18)-Asp(22))[Ala(1),Nle(8),Lys(18),Asp(22),Leu(27)]hPTH(1-31)NH(2) (2, EC(50)=0.29nM).	Lysine	146-149	parathyroid hormone	Homo sapiens	53-57
11875102-2	2002	In the present report we describe a patient with isolated GH deficiency type IB who was heterozygous for two novel mutations in this gene: a missense mutation in codon 329 that replaces lysine with glutamic acid (K329E) and an A--&gt;C transversion (position -124) in one of the two sites of the promoter region that binds the pituitary-specific transcription factor Pit-1, which is required for GHRHR expression.	Lysine	186-192	POU class 1 homeobox 1	Homo sapiens	367-372
11872677-1	2002	NN304 [Lys(B29)-tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog designed to exhibit protracted glucose-lowering action.	Lysine	7-10	insulin	Homo sapiens	45-52
11872677-1	2002	NN304 [Lys(B29)-tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog designed to exhibit protracted glucose-lowering action.	Lysine	7-10	insulin	Homo sapiens	83-90
11882668-0	2002	Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains.	Lysine	21-27	CF transmembrane conductance regulator	Homo sapiens	35-86
11744707-4	2002	Lysines 74 and 405 are present on lobe I of mGluR4.	Lysine	0-7	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	44-50
11744707-8	2002	Mutation of lysine 74 in mGluR4, or the analogous lysine in mGluR8, to tyrosine (mimicking mGluR1 at this position) produced a large decrease in binding.	Lysine	12-18	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	25-31
11875102-2	2002	In the present report we describe a patient with isolated GH deficiency type IB who was heterozygous for two novel mutations in this gene: a missense mutation in codon 329 that replaces lysine with glutamic acid (K329E) and an A--&gt;C transversion (position -124) in one of the two sites of the promoter region that binds the pituitary-specific transcription factor Pit-1, which is required for GHRHR expression.	Lysine	186-192	growth hormone releasing hormone receptor	Homo sapiens	396-401
11748245-9	2002	Interpretation of these results in light of the high-resolution structures of (Ca(2+))(4)-CaM, free and complexed with the CaM-binding domain of MLCK, indicates that a surface domain containing Lys(30) and Gly(40) and residues from the C-terminal domain is created upon binding to MLCK, formation of which is required for activation of MLCK.	Lysine	194-197	calmodulin 1	Homo sapiens	90-93
11850619-4	2002	Such heterochromatin contains histones that are generally hypoacetylated and methylated by Suv39h methyltransferases at lysine 9 of histone H3 (H3-K9).	Lysine	120-126	SUV39H1 histone lysine methyltransferase	Homo sapiens	91-97
11943314-1	2002	Two bovine MHC class II alleles, BoLA-DRB3*0201 and BoLA-DRB3*3301, contain a three base pair deletion which results in the deletion of a lysine (K beta 65) in the antigen recognition site (ARS).	Lysine	138-144	major histocompatibility complex, class II, DRB3	Bos taurus	33-42
11943314-1	2002	Two bovine MHC class II alleles, BoLA-DRB3*0201 and BoLA-DRB3*3301, contain a three base pair deletion which results in the deletion of a lysine (K beta 65) in the antigen recognition site (ARS).	Lysine	138-144	major histocompatibility complex, class II, DRB3	Bos taurus	52-61
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	CREB binding protein	Homo sapiens	129-132
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	CREB binding protein	Homo sapiens	134-154
11952910-1	2002	Transcription of lysine genes in Saccharomyces cerevisiae is dependent on Lys14p and on alpha-aminoadipate semialdehyde (alphaAASA), an intermediate of the pathway.	Lysine	17-23	Lys14p	Saccharomyces cerevisiae S288C	74-80
11748245-9	2002	Interpretation of these results in light of the high-resolution structures of (Ca(2+))(4)-CaM, free and complexed with the CaM-binding domain of MLCK, indicates that a surface domain containing Lys(30) and Gly(40) and residues from the C-terminal domain is created upon binding to MLCK, formation of which is required for activation of MLCK.	Lysine	194-197	calmodulin 1	Homo sapiens	123-126
11673464-3	2002	Using in vitro mutagenesis and a yeast two-hybrid screening assay, we have isolated a mutant ARA54 (mt-ARA54) carrying a point mutation at amino acid 472 changing a glutamic acid to lysine, which acts as a dominant-negative inhibitor of AR transactivation.	Lysine	182-188	ring finger protein 14	Homo sapiens	93-98
11673464-3	2002	Using in vitro mutagenesis and a yeast two-hybrid screening assay, we have isolated a mutant ARA54 (mt-ARA54) carrying a point mutation at amino acid 472 changing a glutamic acid to lysine, which acts as a dominant-negative inhibitor of AR transactivation.	Lysine	182-188	ring finger protein 14	Homo sapiens	103-108
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	6-13	nuclear factor kappa B subunit 1	Homo sapiens	48-51
11673464-3	2002	Using in vitro mutagenesis and a yeast two-hybrid screening assay, we have isolated a mutant ARA54 (mt-ARA54) carrying a point mutation at amino acid 472 changing a glutamic acid to lysine, which acts as a dominant-negative inhibitor of AR transactivation.	Lysine	182-188	androgen receptor	Homo sapiens	93-95
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	6-13	nuclear factor kappa B subunit 1	Homo sapiens	114-117
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	15-18	nuclear factor kappa B subunit 1	Homo sapiens	48-51
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	15-18	nuclear factor kappa B subunit 1	Homo sapiens	114-117
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	24-27	nuclear factor kappa B subunit 1	Homo sapiens	48-51
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	24-27	nuclear factor kappa B subunit 1	Homo sapiens	48-51
11990002-15	2002	Taking into account the very high level of lactuloselysine in the M-SM sample studied, it may be concluded that in common foods such as milk, infant formulas, biscuits, bread, pasta, containing lower levels of blocked lysine, the nutritional loss is primarily due to the loss of lysine and to a less extent to the decrease in the digestibility of other essential AA.	Lysine	218-224	solute carrier family 45 member 1	Homo sapiens	176-181
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	177-184	nuclear factor kappa B subunit 1	Homo sapiens	48-51
11830467-4	2002	Sequencing of GPIIIa complementary DNA from an Oe(a) (+) individual showed deletion of a lysine residue at position 611 (DeltaLys(611)).	Lysine	89-95	integrin subunit beta 3	Homo sapiens	14-20
11772948-3	2002	We have entrapped these iNOS-expressing cells within a semipermeable alginate-poly-L-lysine membrane as a means of delivery to tumor sites in a nude mouse model.	Lysine	78-91	nitric oxide synthase 2, inducible	Mus musculus	24-28
11802720-2	2002	It functions by removing C-terminal lysine residues from partially degraded fibrin that are important in tissue-type plasminogen activator mediated plasmin formation.	Lysine	36-42	plasminogen activator, tissue type	Homo sapiens	105-138
11929601-6	2002	The ubiquitin independence of Ste3p ligand-dependent uptake was further indicated by analysis of receptor mutants having Lys-to-Arg substitutions at all possible ubiquitin acceptor sites.	Lysine	121-124	Ste3p	Saccharomyces cerevisiae S288C	30-35
11802729-10	2002	Moreover, human neutrophils used the myeloperoxidase-H(2)O(2) system to generate sulfinamides in model peptides containing lysine or arginine residues.	Lysine	123-129	myeloperoxidase	Homo sapiens	37-52
11706011-1	2002	Lysyl-tRNA synthetase from higher eukaryotes possesses a lysine-rich N-terminal polypeptide extension appended to a classical prokaryotic-like LysRS domain.	Lysine	57-63	lysyl-tRNA synthetase 1	Homo sapiens	0-21
11706011-1	2002	Lysyl-tRNA synthetase from higher eukaryotes possesses a lysine-rich N-terminal polypeptide extension appended to a classical prokaryotic-like LysRS domain.	Lysine	57-63	lysyl-tRNA synthetase 1	Homo sapiens	143-148
11706011-3	2002	A N-terminally truncated derivative of LysRS, LysRS-DeltaN, displayed a 100-fold lower apparent affinity for tRNA(3)Lys and a 3-fold increase in K(m) for tRNA(3)Lys in the aminoacylation reaction, as compared with the native enzyme.	Lysine	39-42	lysyl-tRNA synthetase 1	Homo sapiens	46-51
11706011-3	2002	A N-terminally truncated derivative of LysRS, LysRS-DeltaN, displayed a 100-fold lower apparent affinity for tRNA(3)Lys and a 3-fold increase in K(m) for tRNA(3)Lys in the aminoacylation reaction, as compared with the native enzyme.	Lysine	46-49	lysyl-tRNA synthetase 1	Homo sapiens	39-44
11742130-0	2002	Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase.	Lysine	51-57	transglutaminase 2	Homo sapiens	18-41
11786336-6	2002	We propose that the lysine-13 of mammalian cytochrome c facilitates the most efficient ET pathway to the carboxylate terminus and this proposal is supported by the ET reaction rate of a rat cytochrome c mutant (RC9-K13A) [Elektrokhimiya (2001) in press], in which lysine-13 is replaced by alanine.	Lysine	20-26	cytochrome c, somatic	Homo sapiens	43-55
11786336-6	2002	We propose that the lysine-13 of mammalian cytochrome c facilitates the most efficient ET pathway to the carboxylate terminus and this proposal is supported by the ET reaction rate of a rat cytochrome c mutant (RC9-K13A) [Elektrokhimiya (2001) in press], in which lysine-13 is replaced by alanine.	Lysine	20-26	cytochrome c, somatic	Homo sapiens	190-202
12438709-8	2002	A very rare polymorphism resulting in a conserved amino acid change Lys to Arg was found in PSCD2.	Lysine	68-71	cytohesin 2	Homo sapiens	92-97
12111653-0	2002	Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia.	Lysine	60-63	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	25-30
12111653-0	2002	Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia.	Lysine	60-63	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-30
11752097-0	2002	[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.	Lysine	9-12	prepronociceptin	Homo sapiens	17-27
11752097-1	2002	The nociceptin (NC)/orphanin FQ analog, [Arg(14),Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP(4)).	Lysine	49-52	prepronociceptin	Homo sapiens	4-14
11752097-1	2002	The nociceptin (NC)/orphanin FQ analog, [Arg(14),Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP(4)).	Lysine	49-52	prepronociceptin	Homo sapiens	20-31
11740489-3	2002	HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 at Ser 46, thus facilitating the CBP-mediated acetylation of p53 at Lys 382, and promoting p53-dependent gene expression.	Lysine	152-155	tumor protein p53	Homo sapiens	80-83
11740489-3	2002	HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 at Ser 46, thus facilitating the CBP-mediated acetylation of p53 at Lys 382, and promoting p53-dependent gene expression.	Lysine	152-155	CREB binding protein	Homo sapiens	117-120
11740489-3	2002	HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 at Ser 46, thus facilitating the CBP-mediated acetylation of p53 at Lys 382, and promoting p53-dependent gene expression.	Lysine	152-155	tumor protein p53	Homo sapiens	145-148
11740489-3	2002	HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 at Ser 46, thus facilitating the CBP-mediated acetylation of p53 at Lys 382, and promoting p53-dependent gene expression.	Lysine	152-155	tumor protein p53	Homo sapiens	145-148
12403639-1	2002	UNLABELLED: Insulin lispro is a recombinant insulin analogue with transposed amino acids (proline and lysine) at positions 28 and 29 near the C-terminus of the B-chain.	Lysine	102-108	insulin	Homo sapiens	12-19
11742130-9	2002	Here, we report that of the 26 lysines present in GAPDH, K191, K268, and K331 were the only amino-donor residues modified by tissue transglutaminase.	Lysine	31-38	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	50-55
11742130-9	2002	Here, we report that of the 26 lysines present in GAPDH, K191, K268, and K331 were the only amino-donor residues modified by tissue transglutaminase.	Lysine	31-38	transglutaminase 2	Homo sapiens	125-148
11812829-7	2001	Mutational studies demonstrate that a single lysine residue is responsible for the low transcriptional activity of Sp3 in vivo.	Lysine	45-51	Sp3 transcription factor	Homo sapiens	115-118
12125021-3	2002	Similarly, an octapeptide with a trimethylated epsilon-amino group derived from the solitary lysine residue of the B-chain of insulin also shows the same relative increase in signal intensity.	Lysine	93-99	insulin	Homo sapiens	126-133
11803535-6	2002	The lysine-lysine distance constraints obtained are discussed in the context of the known NMR and X-ray structures of cytochrome c.	Lysine	4-10	cytochrome c, somatic	Homo sapiens	118-130
11803535-6	2002	The lysine-lysine distance constraints obtained are discussed in the context of the known NMR and X-ray structures of cytochrome c.	Lysine	11-17	cytochrome c, somatic	Homo sapiens	118-130
11751634-0	2001	Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.	Lysine	11-17	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	47-51
11812829-8	2001	We show that Sp3, but not a mutant of Sp3 that lacks this lysine residue, is highly acetylated in vivo.	Lysine	58-64	Sp3 transcription factor	Homo sapiens	13-16
11724579-2	2001	Acetylated HMG1 was isolated from cells grown in the presence of sodium n-butyrate and identified as a monoacetylated protein, modified at lysine 2.	Lysine	139-145	high mobility group box 1 pseudogene 5	Homo sapiens	11-15
11724579-5	2001	Since the modified lysine lies adjacent to the HMG1 DNA-binding domain, the results obtained were attributed to acetylation-induced conformational change in HMG1.	Lysine	19-25	high mobility group box 1 pseudogene 5	Homo sapiens	47-51
11724579-5	2001	Since the modified lysine lies adjacent to the HMG1 DNA-binding domain, the results obtained were attributed to acetylation-induced conformational change in HMG1.	Lysine	19-25	high mobility group box 1 pseudogene 5	Homo sapiens	157-161
11726611-5	2001	Mutation screening of KERA revealed a novel single-nucleotide substitution at codon 215, which results in the substitution of lysine for threonine at the start of a highly conserved leucine-rich repeat motif.	Lysine	126-132	keratocan	Homo sapiens	22-26
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Lysine	86-89	thrombospondin 1	Homo sapiens	40-56
11705740-7	2001	The expression of constitutively active Akt rescues LY-294002-pretreated cells from TNF-alpha- and Fas-mediated apoptosis.	Lysine	52-54	thymoma viral proto-oncogene 1	Mus musculus	40-43
11705740-7	2001	The expression of constitutively active Akt rescues LY-294002-pretreated cells from TNF-alpha- and Fas-mediated apoptosis.	Lysine	52-54	tumor necrosis factor	Mus musculus	84-93
11742862-2	2001	Oxidation may lead to modification of the lysine residues of apolipoprotein B-100 of LDL, which normally mediate the binding of LDL to glycosaminoglycans.	Lysine	42-48	apolipoprotein B	Homo sapiens	61-81
11734662-1	2001	In this study, we investigated tissue-type plasminogen activator (tPA)-induced lysis of glutamic acid (glu)-plasminogen-containing or lysine (lys)-plasminogen-containing thrombin-induced fibrin clots.	Lysine	134-140	plasminogen activator, tissue type	Homo sapiens	66-69
11734662-1	2001	In this study, we investigated tissue-type plasminogen activator (tPA)-induced lysis of glutamic acid (glu)-plasminogen-containing or lysine (lys)-plasminogen-containing thrombin-induced fibrin clots.	Lysine	79-82	plasminogen activator, tissue type	Homo sapiens	31-64
11734662-1	2001	In this study, we investigated tissue-type plasminogen activator (tPA)-induced lysis of glutamic acid (glu)-plasminogen-containing or lysine (lys)-plasminogen-containing thrombin-induced fibrin clots.	Lysine	79-82	plasminogen activator, tissue type	Homo sapiens	66-69
11734662-1	2001	In this study, we investigated tissue-type plasminogen activator (tPA)-induced lysis of glutamic acid (glu)-plasminogen-containing or lysine (lys)-plasminogen-containing thrombin-induced fibrin clots.	Lysine	79-82	coagulation factor II, thrombin	Homo sapiens	170-178
11705946-4	2001	Also, Rac and Cdc42, but not Ras, were transglutaminated with lysine by DeltaDNT.	Lysine	62-68	cell division cycle 42	Bos taurus	14-19
11705946-5	2001	Transglutamination of the GTPase with L-lysine inhibited intrinsic and Rho-GAP-stimulated GTP hydrolysis of RhoA.	Lysine	38-46	ras homolog family member A	Bos taurus	108-112
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Lysine	44-50	ras homolog family member A	Bos taurus	103-107
11705946-9	2001	A comparison of putrescine, spermidine, and lysine as substrates for DNT-induced transglutamination of RhoA revealed that lysine is a preferred second substrate at least in vitro.	Lysine	122-128	ras homolog family member A	Bos taurus	103-107
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	46-52	tumor protein p53	Homo sapiens	26-29
11713475-4	2001	Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged "buttons").	Lysine	187-194	hepatocyte nuclear factor 4 alpha	Homo sapiens	118-121
11713475-4	2001	Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged "buttons").	Lysine	187-194	hepatocyte nuclear factor 4 alpha	Homo sapiens	149-152
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	46-52	tumor protein p53	Homo sapiens	126-129
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	46-52	tumor protein p53	Homo sapiens	126-129
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	256-263	tumor protein p53	Homo sapiens	26-29
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	256-263	tumor protein p53	Homo sapiens	126-129
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	256-263	tumor protein p53	Homo sapiens	126-129
11779497-1	2001	Methylation of histone H3 at lysine 9 by SUV39H1 and subsequent recruitment of the heterochromatin protein HP1 has recently been linked to gene silencing.	Lysine	29-35	SUV39H1 histone lysine methyltransferase	Homo sapiens	41-48
11738050-8	2001	Furthermore, wide clefts are uniquely formed between the two trimers of AUH and are highly positively charged with the Lys residues in alpha helix H1, which is located on the edge of the cleft and contains the majority of the R peptide.	Lysine	119-122	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	72-75
11738050-9	2001	A mutational analysis showed that the lysine residues in alpha helix H1 are essential to the RNA binding activity of AUH.	Lysine	38-44	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	117-120
11500494-4	2001	In this study, we show that Gap1 is ubiquitinated on two lysine residues in the cytosolic N terminus (positions 9 and 16).	Lysine	57-63	amino acid permease GAP1	Saccharomyces cerevisiae S288C	28-32
11500494-5	2001	A mutant Gap1 in which both lysines are mutated (Gap1(K9K16)) remains fully stable at the plasma membrane after NH(4)(+) addition.	Lysine	28-35	amino acid permease GAP1	Saccharomyces cerevisiae S288C	9-13
11500494-5	2001	A mutant Gap1 in which both lysines are mutated (Gap1(K9K16)) remains fully stable at the plasma membrane after NH(4)(+) addition.	Lysine	28-35	amino acid permease GAP1	Saccharomyces cerevisiae S288C	49-53
11555662-3	2001	GzmA cleaved the nucleosome assembly protein SET after Lys(176) and disrupted its nucleosome assembly activity.	Lysine	55-58	granzyme A	Bos taurus	0-4
11524424-11	2001	Further studies of Lys-197, Pro-261, and Lys-420, residues conserved in AGPase sequences, by site-directed mutagenesis suggested that the effectors 3-phosphoglyceric acid and P(i) interact at two closely located binding sites.	Lysine	19-22	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Solanum tuberosum	72-78
11524424-11	2001	Further studies of Lys-197, Pro-261, and Lys-420, residues conserved in AGPase sequences, by site-directed mutagenesis suggested that the effectors 3-phosphoglyceric acid and P(i) interact at two closely located binding sites.	Lysine	41-44	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Solanum tuberosum	72-78
11500494-7	2001	The Gap1(K9) and Gap1(K16) mutants, in which a single lysine is mutated, are down-regulated in response to NH(4)(+) although more slowly.	Lysine	54-60	amino acid permease GAP1	Saccharomyces cerevisiae S288C	4-8
11500494-7	2001	The Gap1(K9) and Gap1(K16) mutants, in which a single lysine is mutated, are down-regulated in response to NH(4)(+) although more slowly.	Lysine	54-60	amino acid permease GAP1	Saccharomyces cerevisiae S288C	17-21
11555652-9	2001	Mutation of Lys-426 within this PEST element both abrogated ligand-dependent down-regulation of glucocorticoid receptor protein and simultaneously enhanced glucocorticoid receptor-induced transcriptional activation of gene expression.	Lysine	12-15	nuclear receptor subfamily 3 group C member 1	Homo sapiens	96-119
11555652-9	2001	Mutation of Lys-426 within this PEST element both abrogated ligand-dependent down-regulation of glucocorticoid receptor protein and simultaneously enhanced glucocorticoid receptor-induced transcriptional activation of gene expression.	Lysine	12-15	nuclear receptor subfamily 3 group C member 1	Homo sapiens	156-179
11698451-6	2001	In the MRL/lpr mice, the catalytic subsets that existed in the initial repertoire were effectively captured by the phosphonyl oxygens in the TSA by interacting with the lysine at H95.	Lysine	169-175	Fas (TNF receptor superfamily member 6)	Mus musculus	11-14
11686679-12	2001	Upon association, five or six side chains in cytochrome c, likely those of lysine, each take up a H+ ion.	Lysine	75-81	cytochrome c, somatic	Homo sapiens	45-57
11713288-7	2001	Finally, the region between the DBD and the oligomerization domain of p53, specifically lysine 305, also plays a critical role in fully revealing p53NES.	Lysine	88-94	tumor protein p53	Homo sapiens	70-73
11495913-4	2001	Furthermore, interaction of p53 with the transcriptional coactivator p300 was induced, and Lys(382) of p53 was acetylated.	Lysine	91-94	tumor protein p53	Homo sapiens	28-31
11500500-4	2001	The formation of the high affinity complex required Arg-142, Lys-143, Arg-145, Lys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin fragment.	Lysine	61-64	apolipoprotein E	Homo sapiens	105-109
11500500-4	2001	The formation of the high affinity complex required Arg-142, Lys-143, Arg-145, Lys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin fragment.	Lysine	79-82	apolipoprotein E	Homo sapiens	105-109
11689210-1	2001	In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation.	Lysine	29-32	apolipoprotein A1	Homo sapiens	21-27
11689210-1	2001	In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation.	Lysine	29-32	apolipoprotein A1	Homo sapiens	70-76
11689210-1	2001	In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation.	Lysine	104-107	apolipoprotein A1	Homo sapiens	21-27
11712396-4	2001	Lys.Pro insulin and insulin aspart, rapid-acting insulin analogues, have demonstrated improved post-prandial glucose control in comparison with regular insulin, even although they are usually administered immediately prior to the meal.	Lysine	0-3	insulin	Homo sapiens	8-15
11712396-4	2001	Lys.Pro insulin and insulin aspart, rapid-acting insulin analogues, have demonstrated improved post-prandial glucose control in comparison with regular insulin, even although they are usually administered immediately prior to the meal.	Lysine	0-3	insulin	Homo sapiens	20-27
11495913-4	2001	Furthermore, interaction of p53 with the transcriptional coactivator p300 was induced, and Lys(382) of p53 was acetylated.	Lysine	91-94	tumor protein p53	Homo sapiens	103-106
11557524-5	2001	Substitution of Leu at position 1084 of rat MRP3 (which corresponds to Arg-1096 in rat MRP2) with Lys, but not with Val or Met, resulted in the loss of transport activity for TC and glucuronide conjugates.	Lysine	98-101	ATP binding cassette subfamily C member 3	Rattus norvegicus	44-48
11579203-5	2001	Truncation of the AT(1A) receptor to lysine(325) prevented AngII-induced phosphorylation and beta-arrestin 1 association as well as markedly inhibiting receptor internalization, indicating a close correlation between these receptor parameters.	Lysine	37-43	arrestin beta 1	Homo sapiens	93-108
11562448-9	2001	Transfection of cDNA for the dominant-negative mutant JNK-KR or stress-activated protein kinase kinase-1 Lys--&gt;Arg mutant (SEK1-KR), an immediate upstream kinase of JNK, significantly reduced AAP-induced JNK activation and cell death rate.	Lysine	105-108	mitogen-activated protein kinase kinase 4	Homo sapiens	64-104
11886082-0	2001	Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine.	Lysine	107-115	insulin	Homo sapiens	0-7
11473115-0	2001	Identification of a critical lysine residue in apolipoprotein B-100 that mediates noncovalent interaction with apolipoprotein(a).	Lysine	29-35	apolipoprotein B	Homo sapiens	47-67
11473115-6	2001	Lysine residues present in this sequence (Lys(680) and Lys(690)) were mutated to alanine in the context of apoB-18.	Lysine	0-6	apolipoprotein B	Homo sapiens	107-111
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	41-47	apolipoprotein B	Homo sapiens	60-68
11473115-6	2001	Lysine residues present in this sequence (Lys(680) and Lys(690)) were mutated to alanine in the context of apoB-18.	Lysine	0-3	apolipoprotein B	Homo sapiens	107-111
11473115-6	2001	Lysine residues present in this sequence (Lys(680) and Lys(690)) were mutated to alanine in the context of apoB-18.	Lysine	42-45	apolipoprotein B	Homo sapiens	107-111
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	41-47	apolipoprotein B	Homo sapiens	60-64
11473115-7	2001	We found that the apoB-18 species containing the Lys(680) mutation was incapable of binding to r-apo(a)-Sepharose columns, whereas the apoB-18 species containing the Lys(690) mutation exhibited slightly reduced binding to these columns.	Lysine	49-52	apolipoprotein B	Homo sapiens	18-22
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	197-203	apolipoprotein B	Homo sapiens	60-68
11473115-7	2001	We found that the apoB-18 species containing the Lys(680) mutation was incapable of binding to r-apo(a)-Sepharose columns, whereas the apoB-18 species containing the Lys(690) mutation exhibited slightly reduced binding to these columns.	Lysine	166-169	apolipoprotein B	Homo sapiens	135-139
11473115-8	2001	Taken together, our data indicate that Lys(680) is critical for the noncovalent interaction of apo(a) and apoB-100 that precedes covalent Lp(a) formation.	Lysine	39-42	apolipoprotein B	Homo sapiens	106-114
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	197-203	apolipoprotein B	Homo sapiens	60-64
11473115-3	2001	To identify specific lysine residues in the amino terminus of apoB that are required for the noncovalent interaction, we initially used an affinity chromatography method in which recombinant forms of apo(a) (r-apo(a)) were immobilized on Sepharose beads.	Lysine	21-27	apolipoprotein B	Homo sapiens	62-66
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	203-209	apolipoprotein B	Homo sapiens	62-66
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	203-209	apolipoprotein B	Homo sapiens	142-146
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	203-209	apolipoprotein B	Homo sapiens	142-146
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	251-257	apolipoprotein B	Homo sapiens	62-66
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	251-257	apolipoprotein B	Homo sapiens	142-146
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	251-257	apolipoprotein B	Homo sapiens	142-146
11432860-4	2001	A search for single substitutions to Gln among all conserved basic residues (Lys/Arg) in human ACE C-domain identified R1098Q as the sole mutant that lacked Cl(-) dependence.	Lysine	77-80	angiotensin I converting enzyme	Homo sapiens	95-98
11432854-2	2001	The conserved lysine in the Walker A motif of the ATP-binding domain encoded by the yeast RFC1, RFC2, RFC3, and RFC4 genes was mutated to glutamic acid.	Lysine	14-20	replication factor C subunit 3	Saccharomyces cerevisiae S288C	102-106
11432854-9	2001	Mutant RFC complexes containing rfc2-K71R or rfc3-K59R, carrying a conservative lysine --&gt; arginine mutation, had much milder clamp loading defects that could be partially (rfc2-K71R) or completely (rfc3-K59R) suppressed at high ATP concentrations.	Lysine	80-86	replication factor C subunit 3	Saccharomyces cerevisiae S288C	45-49
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Lysine	105-111	replication factor C subunit 3	Saccharomyces cerevisiae S288C	149-153
11524012-2	2001	HD1 deacetylates lysines 5 and 16 of H4 in the order K16 &gt; K5, while in the case of H3 the preferred order is K4 &gt;&gt; K18 approximately K9.	Lysine	17-24	histone deacetylase 1	Homo sapiens	0-3
11451953-1	2001	The smallest known open reading frame encodes the ribosomal protein L41, which in yeast is composed of only 24 amino acids, 17 of which are arginine or lysine.	Lysine	152-158	ribosomal protein L41	Homo sapiens	68-71
11523984-5	2001	However, when lipoprotein(a) was treated with a lysine analogue, 6-aminohexanoic acid, much of the apolipoprotein(a) separated from the apolipoprotein B-100.	Lysine	48-54	apolipoprotein B	Homo sapiens	136-156
11438549-7	2001	Mutation of Lys(624) to cysteine produced approximately 6-8-fold more A beta than cells expressing normal APP.	Lysine	12-15	amyloid beta precursor protein	Homo sapiens	70-76
11571656-3	2001	The same amino acid alteration was recently described for rat WNK1 (with no K=lysine) in which another nearby lysine residue was shown to confer kinase activity to the protein.	Lysine	110-116	WNK lysine deficient protein kinase 1	Rattus norvegicus	62-66
11487527-3	2001	Rabbit aortic SMCs express a baseline population of B(1)Rs that was up-regulated upon interleukin-1beta treatment ([(3)H]-Lys-des-Arg(9)-BK binding or mRNA concentration evaluated by RT - PCR; 4 or 3 h, respectively).	Lysine	122-125	interleukin-1 beta	Oryctolagus cuniculus	86-103
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	YY1 transcription factor	Homo sapiens	0-3
11522292-4	2001	Cleavage occurs at one site, between Ser-143 and Lys-144 of IGFBP-5.	Lysine	49-52	insulin like growth factor binding protein 5	Homo sapiens	60-67
11498590-3	2001	We show that the accurate execution of the IFN-beta transcriptional switch depends on the ordered acetylation of the high-mobility group I protein HMGI(Y) by PCAF/GCN5 and CBP, which acetylate HMGI(Y) at distinct lysine residues on endogenous promoters.	Lysine	213-219	CREB binding protein	Homo sapiens	172-175
11498590-4	2001	Whereas acetylation of HMGI(Y) by CBP at lysine-65 destabilizes the enhanceosome, acetylation of HMGI(Y) by PCAF/GCN5 at lysine-71 potentiates transcription by stabilizing the enhanceosome and preventing acetylation by CBP.	Lysine	41-47	CREB binding protein	Homo sapiens	34-37
11498592-5	2001	Our results show that Snf1 and the acetyltransferase Gcn5 function in an obligate sequence to enhance INO1 transcription by modifying histone H3 serine-10 and lysine-14.	Lysine	159-165	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	102-106
11522682-9	2001	Because the condensation of glucose and lysine residues is an ubiquitous and unavoidable process in homeothermic organisms, a deglycation system mediated by FN3K may be an important factor in protecting cells from the deleterious effects of nonenzymatic glycation.	Lysine	40-46	fructosamine 3 kinase	Homo sapiens	157-161
11520855-7	2001	In addition, our results reveal an inverse correlation between HDAC-1 recruitment and histone H4 acetylation on specific lysines.	Lysine	121-128	histone deacetylase 1	Homo sapiens	63-69
11418614-4	2001	Conversely, mutation of the lysine 1136 inhibited the ability of the cells to increase cyclin E and cdk2 expression, to maintain long term phosphorylation of the ERK MAPK, and to enter S-phase but had no effect on the ability of the cells to phosphorylate the p38 MAPK or to migrate on type I collagen in response to EGF.	Lysine	28-34	mitogen-activated protein kinase 14	Homo sapiens	260-263
11485557-5	2001	Five residues of GST I (Ser(11), His(40), Lys(41), Gln(53) and Ser(67)), which are located in the G-site, were individually replaced with alanine and their structural and functional roles in the 1-chloro-2,4-dinitrobenzene (CDNB) conjugation reaction were investigated.	Lysine	42-45	glutathione S-transferase 1	Zea mays	17-22
11478852-1	2001	Two residues have been shown to be critical for the kinase activity of the receptor for epidermal growth factor (EGF): lysine-721, which functions in the binding of ATP by correctly positioning the gamma-phosphate for phosphoryl transfer, and aspartate-813, which functions as the catalytic base of the kinase.	Lysine	119-125	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	88-111
11478852-1	2001	Two residues have been shown to be critical for the kinase activity of the receptor for epidermal growth factor (EGF): lysine-721, which functions in the binding of ATP by correctly positioning the gamma-phosphate for phosphoryl transfer, and aspartate-813, which functions as the catalytic base of the kinase.	Lysine	119-125	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	113-116
11478852-3	2001	However, studies performed in different laboratories had suggested that while EGF receptors mutated at lysine-721 are unable to stimulate significant increases of [(3)H]thymidine incorporation into DNA in response to EGF treatment, cells expressing EGF receptors mutated at aspartate-813 do stimulate significant incorporation of [(3)H]thymidine into DNA in response to EGF.	Lysine	103-109	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	78-81
11478852-4	2001	In the present study, EGF receptors mutated at lysine-721 or aspartate-813 (K721R and D813A, respectively), as well as wild-type EGF receptors, were expressed in the same cellular background, Chinese hamster ovary cells, and side-by-side experiments were performed to investigate possible signaling-related differences.	Lysine	47-53	LOW QUALITY PROTEIN: pro-epidermal growth factor	Cricetulus griseus	22-25
11481424-7	2001	Furthermore, p33ING2 expression increases the acetylation of p53 at Lys-382.	Lysine	68-71	tumor protein p53	Homo sapiens	61-64
11484059-2	2001	Lysine 9 of histone H3 is methylated by SUV39H1 (ref.	Lysine	0-6	SUV39H1 histone lysine methyltransferase	Homo sapiens	40-47
11531804-6	2001	We also report a novel amino acid substitution mutation in codon 192 of KRT2E (asparagine to lysine) in the conserved 1A helix initiation peptide of the protein in the patient with IBS.	Lysine	93-99	keratin 2	Homo sapiens	72-77
11523781-5	2001	Moreover, the rad1 ntg1 ntg2 strain is hypermutable (CanR and Lys+) upon exposure to H2O2, relative to WT, rad1 and ntg1 ntg2 strains.	Lysine	62-65	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	14-18
11500547-5	2001	This interaction was greatly reduced when lysine-462 of PRK1-K, believed to be essential for kinase activity, was replaced with arginine (the resulting protein is named PRK1-K462R).	Lysine	42-48	serine/threonine protein kinase PRK1	Saccharomyces cerevisiae S288C	56-60
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Lysine	285-288	ribonuclease pancreatic	Bos taurus	107-114
11500547-5	2001	This interaction was greatly reduced when lysine-462 of PRK1-K, believed to be essential for kinase activity, was replaced with arginine (the resulting protein is named PRK1-K462R).	Lysine	42-48	serine/threonine protein kinase PRK1	Saccharomyces cerevisiae S288C	169-173
11453652-2	2001	Arpp protein is composed of 333 amino acids and contains four ankyrin-like repeat motifs in the middle portion of the protein, a PEST-like sequence and a lysine-rich sequence similar to a nuclear localization signal in the N-terminal region, and a proline-rich region containing consensus phosphorylation sites in the C-terminal region.	Lysine	154-160	ankyrin repeat domain 2	Homo sapiens	0-4
11384967-4	2001	Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5.	Lysine	4-11	CREB binding protein	Homo sapiens	53-56
11384967-5	2001	The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat.	Lysine	29-36	CREB binding protein	Homo sapiens	45-48
11384967-6	2001	These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.	Lysine	58-65	CREB binding protein	Homo sapiens	198-201
11319229-3	2001	Furthermore, the C-terminal lysine residues of its p11 subunit play an essential role in the inhibition of fibrin clot lysis by AIIt.	Lysine	28-34	S100 calcium binding protein A10	Homo sapiens	51-54
11459667-0	2001	Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors.	Lysine	89-95	coagulation factor II, thrombin	Homo sapiens	114-122
11459667-1	2001	Seven non-natural analogues of arginine and lysine have been substituted in an established arginine-based thrombin inhibitor.	Lysine	44-50	coagulation factor II, thrombin	Homo sapiens	106-114
11316813-4	2001	Like Suv39 h1, the first identified lysine-preferring mammalian HMTase, G9a transfers methyl groups to the lysine residues of histone H3, but with a 10-20-fold higher activity.	Lysine	36-42	SUV39H1 histone lysine methyltransferase	Homo sapiens	5-13
11316813-6	2001	G9a was able to add methyl groups to lysine 27 as well as 9 in H3, compared with Suv39 h1, which was only able to methylate lysine 9.	Lysine	124-130	SUV39H1 histone lysine methyltransferase	Homo sapiens	81-89
11459451-3	2001	To determine the significance of that hydrophobicity, we have now synthesized dipeptide analogues conjugating the epsilon-amino group of Lys in Val-Lys with aliphatic carboxylic acids: acetic acid (C2), propanoic acid (C3), pentanoic acid (C5), hexanoic acid (C6), and decanoic acid (C10).	Lysine	137-140	homeobox C10	Homo sapiens	284-287
11425316-7	2001	All compounds enhanced the rate of aggregation of Abeta, with the magnitude of the effect increasing as the number of lysines in the disrupting element increased.	Lysine	118-125	amyloid beta precursor protein	Homo sapiens	50-55
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Lysine	110-116	neurotrophin 4	Homo sapiens	22-26
11432824-0	2001	Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.	Lysine	0-6	proteasome activator subunit 3	Homo sapiens	73-81
11732685-0	2001	Mutation of lysine residues of the 78-kDa gastrin-binding protein reduces gastrin binding.	Lysine	12-18	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	42-65
11479737-10	2001	DNA sequencing of APOH*4 carriers revealed a missense mutation in exon 6 (A--&gt;G) at codon 210, which replaces the amino acid lysine by glutamic acid.	Lysine	128-134	apolipoprotein H	Pan troglodytes	18-22
11699729-3	2001	It is now generally accepted that Lp(a) assembly is a two-step process in which the initial non-covalent interaction between apo(a) and apo B-100 is mediated by the weak lysine binding sites present in kringle IV types 6, 7 and 8 of apo(a).	Lysine	170-176	apolipoprotein B	Homo sapiens	136-145
11301317-4	2001	The PITX2 homeodomain has a lysine at position 50, which has been shown to impart the bicoid-type (TAATCC) DNA binding specificity to other homeodomain proteins.	Lysine	28-34	paired like homeodomain 2	Homo sapiens	4-9
11287425-7	2001	Analysis revealed that YB-1 affects the steady state equilibrium between the covalent hNth1-AP site Schiff base ES intermediate and the noncovalent ES intermediate containing the AP aldehydic sugar and the epsilon-amino group of the hNth1 active site lysine.	Lysine	251-257	Y-box binding protein 1	Homo sapiens	23-27
11408167-4	2001	Kinetic studies using agarose gel electrophoresis showed that cyclic peptide 7b and Lys-Trp-Lys possessed DNA nicking activity on natural supercoiled phi X174 DNA with nicking rate of 50.7 and 75.6 pM min(-1) at 65 degrees C, respectively, whereas cyclic peptide 7a and linear Lys-Tyr-Lys were devoid of the corresponding activity.	Lysine	92-95	CD59 molecule (CD59 blood group)	Homo sapiens	201-207
11732685-3	2001	In order to define the gastrin-binding sites of the GBP in greater detail, we have constructed a truncation mutant lacking residues 221-318 of the N-terminal domain and a series of point mutants in which the lysine residues in the first 220 residues of the N-terminal domain were mutated to arginine residues.	Lysine	208-214	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	52-55
11732685-6	2001	Mutation of the 17 lysines in residues 1-220 of the GBP decreased the affinity for gastrin between 1.7- and 3.5-fold and in some cases reduced, but did not abolish, the extent of covalent cross-linking.	Lysine	19-26	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	52-55
11732685-7	2001	We conclude that one or more lysine residues are involved in binding of gastrin to the GBP, but that no single lysine residue is the preferred target for covalent cross-linking of iodinated gastrin2,17 to the GBP.	Lysine	29-35	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	87-90
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Lysine	44-47	mitogen-activated protein kinase 1	Homo sapiens	157-161
11320079-11	2001	Expressed full-length FDH with the substitution of lysine for the His(106) completely lost both the hydrolase and dehydrogenase activities.	Lysine	51-57	aldehyde dehydrogenase 1 family member L1	Homo sapiens	22-25
11381133-6	2001	The substitution of key lysine residues in the Walker A motifs of TAP1 and TAP2 suggests that TAP1-mediated ATP hydrolysis is not essential for peptide translocation but that TAP2-mediated ATP hydrolysis is critical, not only for translocation, but for peptide binding.	Lysine	24-30	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	66-70
11381133-6	2001	The substitution of key lysine residues in the Walker A motifs of TAP1 and TAP2 suggests that TAP1-mediated ATP hydrolysis is not essential for peptide translocation but that TAP2-mediated ATP hydrolysis is critical, not only for translocation, but for peptide binding.	Lysine	24-30	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	94-98
11264294-6	2001	We showed that PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144.	Lysine	85-88	insulin like growth factor binding protein 5	Homo sapiens	44-51
11408167-4	2001	Kinetic studies using agarose gel electrophoresis showed that cyclic peptide 7b and Lys-Trp-Lys possessed DNA nicking activity on natural supercoiled phi X174 DNA with nicking rate of 50.7 and 75.6 pM min(-1) at 65 degrees C, respectively, whereas cyclic peptide 7a and linear Lys-Tyr-Lys were devoid of the corresponding activity.	Lysine	84-87	CD59 molecule (CD59 blood group)	Homo sapiens	201-207
11408167-4	2001	Kinetic studies using agarose gel electrophoresis showed that cyclic peptide 7b and Lys-Trp-Lys possessed DNA nicking activity on natural supercoiled phi X174 DNA with nicking rate of 50.7 and 75.6 pM min(-1) at 65 degrees C, respectively, whereas cyclic peptide 7a and linear Lys-Tyr-Lys were devoid of the corresponding activity.	Lysine	92-95	CD59 molecule (CD59 blood group)	Homo sapiens	201-207
11369796-3	2001	The pK(a) values of lysines (K) at positions 143 and 146 in the LDLR-binding region in DMPC-associated 22-kDa apoE fragments were 9.4 and 9.9 in apoE2, 9.5 and 9.2 in apoE3, and 9.9 and 9.4 in apoE4, respectively.	Lysine	20-27	apolipoprotein E	Homo sapiens	110-114
11369796-3	2001	The pK(a) values of lysines (K) at positions 143 and 146 in the LDLR-binding region in DMPC-associated 22-kDa apoE fragments were 9.4 and 9.9 in apoE2, 9.5 and 9.2 in apoE3, and 9.9 and 9.4 in apoE4, respectively.	Lysine	20-27	apolipoprotein E	Homo sapiens	145-150
11369796-3	2001	The pK(a) values of lysines (K) at positions 143 and 146 in the LDLR-binding region in DMPC-associated 22-kDa apoE fragments were 9.4 and 9.9 in apoE2, 9.5 and 9.2 in apoE3, and 9.9 and 9.4 in apoE4, respectively.	Lysine	20-27	apolipoprotein E	Homo sapiens	167-172
11369796-3	2001	The pK(a) values of lysines (K) at positions 143 and 146 in the LDLR-binding region in DMPC-associated 22-kDa apoE fragments were 9.4 and 9.9 in apoE2, 9.5 and 9.2 in apoE3, and 9.9 and 9.4 in apoE4, respectively.	Lysine	20-27	apolipoprotein E	Homo sapiens	193-198
11369801-7	2001	Cleavage in the middle of apoA-I occurs at distinct sites in 7.8-nm (Lys(118)) and 12.7-nm (Arg(123)) rHDL, indicating a different conformation in small and large rHDL particles.	Lysine	69-72	apolipoprotein A1	Homo sapiens	26-32
11356952-5	2001	The same result was achieved upon mutation of a single lysine residue of the NDK V3 loop to alanine (K319A) but not to arginine (K319R).	Lysine	55-61	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	77-80
11331368-6	2001	In vitro studies revealed that the ERK cascade could regulate the lysine acetylation of a 42 kDa lysine acetyltransferase substrate, suggesting a causal relationship between ERK activation and lysine acetyltransferase activity in insular cortex.	Lysine	66-72	mitogen-activated protein kinase 1	Homo sapiens	35-38
11407896-1	2001	Poly-l-lysine, with 40% of its amino groups substituted with lactose, is an effective vector to transfer the CFTR gene into CF airway epithelial cells and correct the chloride channel dysfunction.	Lysine	0-13	CF transmembrane conductance regulator	Homo sapiens	109-113
11477223-7	2001	Our results demonstrate that the strong lysine binding site in apo(a) KIV (10) is capable of mediating interactions with plasmin-modified fibrinogen in a lysine-dependent manner, and that this kringle can increase in vitro fibrin clot lysis time by approximately 43% at a concentration of 10 microM KIV (10).	Lysine	40-46	fibrinogen beta chain	Homo sapiens	138-148
11477223-7	2001	Our results demonstrate that the strong lysine binding site in apo(a) KIV (10) is capable of mediating interactions with plasmin-modified fibrinogen in a lysine-dependent manner, and that this kringle can increase in vitro fibrin clot lysis time by approximately 43% at a concentration of 10 microM KIV (10).	Lysine	154-160	fibrinogen beta chain	Homo sapiens	138-148
11477223-8	2001	The ability of the KIV (10) mutant derivatives to bind plasmin-modified fibrinogen correlated with their lysine binding capacity.	Lysine	105-111	fibrinogen beta chain	Homo sapiens	72-82
11477223-11	2001	Apo(a) KIV (7) contains a lysine- and proline-sensitive site capable of mediating binding to plasmin-modified fibrinogen, albeit with a lower apparent affinity than apo(a) KIV (10).	Lysine	26-32	fibrinogen beta chain	Homo sapiens	110-120
11279135-5	2001	p300, but not P/CAF, selectively and directly acetylated the ERalpha at lysine residues within the ERalpha hinge/ligand binding domain.	Lysine	72-78	estrogen receptor 1	Homo sapiens	61-68
11279135-5	2001	p300, but not P/CAF, selectively and directly acetylated the ERalpha at lysine residues within the ERalpha hinge/ligand binding domain.	Lysine	72-78	estrogen receptor 1	Homo sapiens	99-106
11279135-7	2001	These ERalpha lysine residues also regulated transcriptional activation by histone deacetylase inhibitors and p300.	Lysine	14-20	estrogen receptor 1	Homo sapiens	6-13
11278381-4	2001	Our results identify lysine 82 as the major site of SUMO-1 modification in HSF2, which is located in a "wing" within the DNA-binding domain of this protein.	Lysine	21-27	heat shock transcription factor 2	Homo sapiens	75-79
11279157-4	2001	Mass spectral analysis revealed that there are at least two lysine residues acetylated in PC4, as a result of which its DNA binding activity is stimulated.	Lysine	60-66	SUB1 regulator of transcription	Homo sapiens	90-93
11288181-0	2001	Replacement of thrombin residue G184 with Lys or Arg fails to mimic Na+ binding.	Lysine	42-45	coagulation factor II, thrombin	Homo sapiens	15-23
11288181-3	2001	Molecular modeling indicates that the G184K substitution in thrombin positions the protonated epsilon-amino group of the Lys side-chain to replace the bound Na+.	Lysine	121-124	coagulation factor II, thrombin	Homo sapiens	60-68
11331368-6	2001	In vitro studies revealed that the ERK cascade could regulate the lysine acetylation of a 42 kDa lysine acetyltransferase substrate, suggesting a causal relationship between ERK activation and lysine acetyltransferase activity in insular cortex.	Lysine	66-72	mitogen-activated protein kinase 1	Homo sapiens	174-177
11297527-7	2001	Site-directed mutagenesis suggested an important role for lysine 131 of CLP in mediating 5LO binding.	Lysine	58-64	arachidonate 5-lipoxygenase	Homo sapiens	89-92
11150296-0	2001	Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.	Lysine	9-15	interferon alpha 1	Homo sapiens	55-65
11150296-8	2001	The results suggest that two arginine/lysine-rich elements, one in each STAT monomer, are required for IFN-induced nuclear import of STAT dimers.	Lysine	38-44	interferon alpha 1	Homo sapiens	103-106
11426702-5	2001	K(M) and Vmax values, which were obtained for cow kappa-casein, showed that cow kappa-casein was a better susbstrate for trypsin than the others, suggesting that cow kappa-casein has a rich content of lysine, arginine, and aromatic amino acids by comparison with the others.	Lysine	201-207	casein kappa	Bos taurus	80-92
11311125-3	2001	We demonstrate that uPA, associated with the surface of U937 cells, undergoes plasmin-mediated cleavage of the Lys(46)-Ser(47) bond with elimination of the GFD.	Lysine	111-114	plasminogen activator, urokinase	Homo sapiens	20-23
11329144-4	2001	Mutation analysis of the ZNF189 gene in bladder cancer cell lines identified one amino acid substitution (lysine--&gt;isoleucine) at position 323 in exon 4.	Lysine	106-112	zinc finger protein 189	Homo sapiens	25-31
11377692-1	2001	The N-terminal region of bovine serum albumin (Asp-Thr-His-Lys) is known to provide a specific binding site for Cu(II) ions, with the histidine residue thought to be mainly responsible for the specificity.	Lysine	59-62	albumin	Homo sapiens	32-45
11306683-3	2001	This article explores the role of these residues in transport function by the development of cell lines in which arginines and lysines in RFC1 were replaced with leucine by site-directed mutagenesis.	Lysine	127-134	replication factor C (activator 1) 1	Mus musculus	138-142
11426702-5	2001	K(M) and Vmax values, which were obtained for cow kappa-casein, showed that cow kappa-casein was a better susbstrate for trypsin than the others, suggesting that cow kappa-casein has a rich content of lysine, arginine, and aromatic amino acids by comparison with the others.	Lysine	201-207	casein kappa	Bos taurus	80-92
11278633-8	2001	These results demonstrate that the alpha(M)(Lys(245)-Arg(261)) segment, a site of the major sequence and structure difference among alpha(M)I-, alpha(X)I-, and alpha(L)I-domains, is responsible for recognition of a small segment of fibrinogen, gammaThr(383)-Gly(395), by serving as ligand binding site.	Lysine	44-47	fibrinogen beta chain	Homo sapiens	232-242
11294645-2	2001	Here we show that the lysine-rich part of the linker region between A and B domains of HMG-1, the (85)TKKKFKD(91) sequence that is attached to the N-terminus of the B domain within HMG-1, is a prerequisite for a preferential binding of the B domain to supercoiled DNA.	Lysine	22-28	high mobility group box 1 pseudogene 5	Homo sapiens	87-92
11294645-2	2001	Here we show that the lysine-rich part of the linker region between A and B domains of HMG-1, the (85)TKKKFKD(91) sequence that is attached to the N-terminus of the B domain within HMG-1, is a prerequisite for a preferential binding of the B domain to supercoiled DNA.	Lysine	22-28	high mobility group box 1 pseudogene 5	Homo sapiens	181-186
11414735-6	2001	Porcine MDL-1 contains a conserved lysine in the transmembrane domain.	Lysine	35-41	C-type lectin domain containing 5A	Homo sapiens	8-13
11150308-0	2001	The lysine-rich C-terminal tail of heparin affin regulatory peptide is required for mitogenic and tumor formation activities.	Lysine	4-10	pleiotrophin	Homo sapiens	35-67
11150308-6	2001	Our data clearly indicate that the residues 111-136 of the lysine-rich C-terminal domain are involved in the mitogenic and tumor formation activities of HARP.	Lysine	59-65	pleiotrophin	Homo sapiens	153-157
11118430-6	2001	These studies showed that cationic residues, Lys(7), Lys(11), and Arg(34), constitute a part of the interfacial binding surface of hVPLA(2), which accounts for its moderate preference for anionic membranes.	Lysine	45-48	phospholipase A2 group V	Homo sapiens	131-139
11118430-6	2001	These studies showed that cationic residues, Lys(7), Lys(11), and Arg(34), constitute a part of the interfacial binding surface of hVPLA(2), which accounts for its moderate preference for anionic membranes.	Lysine	53-56	phospholipase A2 group V	Homo sapiens	131-139
11300748-5	2001	A three-step method was used to achieve high efficiency of transfection: (1) permeabilization of primary cells using a mild detergent, (2) association of plasmid DNAs with a polycationic (poly-l-lysine) core covalently linked to a receptor ligand (transferrin), (3) introduction of cationic liposomes to form the quaternary complex.	Lysine	188-201	transferrin	Homo sapiens	231-264
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	71-74	CREB binding protein	Homo sapiens	28-48
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	71-74	CREB binding protein	Homo sapiens	50-53
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	113-116	CREB binding protein	Homo sapiens	28-48
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	113-116	CREB binding protein	Homo sapiens	50-53
11259590-7	2001	Although site-specific DNA binding by EKLF is unaffected by the acetylation status of either of these lysines, directed mutagenesis of Lys-288 (but not Lys-302) decreases the ability of EKLF to transactivate the beta-globin promoter in vivo and renders it unable to be superactivated by coexpressed p300 or CBP.	Lysine	135-138	CREB binding protein	Homo sapiens	307-310
11154691-6	2001	Immunoprecipitation experiments with anti-acetyl lysine antibodies demonstrate that MafG is acetylated in vivo in erythroid cells.	Lysine	49-55	MAF bZIP transcription factor G	Homo sapiens	84-88
11298551-4	2001	Mutation analysis of the PPOX gene revealed an in-frame 12 bp insert (c. 657-658 ins AAGGCCAGCGCC) encoding lysine-alanine-serine-alanine (KASA), and a G to A transition at the splice donor site of exon 11 (IVS 11-1 G--&gt;A).	Lysine	108-114	protoporphyrinogen oxidase	Homo sapiens	25-29
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Lysine	126-134	aryl hydrocarbon receptor interacting protein	Homo sapiens	0-3
11099504-0	2001	Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.	Lysine	9-15	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	29-33
11099504-1	2001	We generated mutants of the transporter associated with antigen-processing subunits TAP1 and TAP2 that were altered at the conserved lysine residue in the Walker A motifs of the nucleotide binding domains (NBD).	Lysine	133-139	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	84-88
11102442-5	2001	The mutation to serine of Glu-504, a residue that is conserved in both mu- and m-calpain and interacts most notably with Lys-234, reduced the in vitro Ca(2+) requirement for activity by almost 50%.	Lysine	121-124	calpain 2	Homo sapiens	79-88
11102443-1	2001	Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84% identity) that catalyze release of acetyl groups from modified N-terminal lysines of core histones.	Lysine	155-162	histone deacetylase 1	Homo sapiens	30-35
11102443-1	2001	Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84% identity) that catalyze release of acetyl groups from modified N-terminal lysines of core histones.	Lysine	155-162	histone deacetylase 2	Homo sapiens	45-50
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	59-67	aryl hydrocarbon receptor interacting protein	Homo sapiens	122-125
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	59-67	aryl hydrocarbon receptor interacting protein	Homo sapiens	211-214
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	177-185	aryl hydrocarbon receptor interacting protein	Homo sapiens	122-125
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	177-185	aryl hydrocarbon receptor interacting protein	Homo sapiens	211-214
11319613-8	2001	These results indicate that AIP induces apoptosis in cells by two distinct mechanisms; one rapid and mediated by H2O2, the other delayed and mediated by deprivation of L-lysine, both of which utilize caspase-9/cytochrome c system.	Lysine	168-176	aryl hydrocarbon receptor interacting protein	Homo sapiens	28-31
11245429-7	2001	By analyzing the acetylation of specific lysine residues at the amino terminus of histone H4 (Ac-5, Ac-8, Ac-12, and Ac-16), we found that the enhancement of HDAC inhibitor-induced acetylation of histones in the DAC-pretreated cells was not lysine site specific.	Lysine	41-47	adenylate cyclase 5	Homo sapiens	94-98
11244108-3	2001	Elongation factor 1alpha (eEF1A) is one of these proteins, and its concentration is highly correlated with the Lys content of the endosperm.	Lysine	111-114	LOC541783	Zea mays	0-24
11042197-5	2001	Lys(193) is also required for a specific interaction with the zinc finger transcription factor GATA4.	Lysine	0-3	GATA binding protein 4	Mus musculus	95-100
11242053-3	2001	Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.	Lysine	88-94	SUV39H1 histone lysine methyltransferase	Homo sapiens	98-104
11314025-5	2001	Inhibition of focal contacts development by plating of cells onto poly-L-lysine abrogated both Erk1/2 and p53 activations in colcemid-treated cells, while plating of cells onto fibronectin caused transient up-regulation of p53 even in the absence of colcemid.	Lysine	66-79	mitogen-activated protein kinase 3	Homo sapiens	95-101
11314025-5	2001	Inhibition of focal contacts development by plating of cells onto poly-L-lysine abrogated both Erk1/2 and p53 activations in colcemid-treated cells, while plating of cells onto fibronectin caused transient up-regulation of p53 even in the absence of colcemid.	Lysine	66-79	tumor protein p53	Homo sapiens	106-109
11327820-4	2001	We have examined the role of two lysines, Lys206 and Lys296, that form a hydrogen-bonded pair close to the N-lobe binding site of human Tf and have been proposed to form a pH-sensitive trigger for iron release.	Lysine	33-40	transferrin	Homo sapiens	136-138
11073948-5	2001	Consistent with this observation, CBP acetylated c-Myb in vitro at Lys(438) and Lys(441) within the NRD.	Lysine	67-70	CREB binding protein	Homo sapiens	34-37
11050076-4	2001	It covalently labeled the CCK receptor either within the amino terminus (between Asn(10) and Lys(37)) or within the third extracellular loop (Glu(345)), as demonstrated by proteolytic peptide mapping, deglycosylation, micropurification, and Edman degradation sequencing.	Lysine	93-96	cholecystokinin	Homo sapiens	26-29
11314003-0	2001	A single Glu(62)-to-Lys(62) mutation in the Mos residues of the R7Delta447Gag-tMos protein causes the mutant virus to induce brain lesions.	Lysine	20-23	Moloney sarcoma oncogene	Mus musculus	44-47
11314003-3	2001	The genomes of the two viruses differ in a single base pair: the deduced Glu(62) of the Mos residue of the R7Delta447 Gag-tMos protein is changed to Lys(62).	Lysine	149-152	Moloney sarcoma oncogene	Mus musculus	88-91
11314003-3	2001	The genomes of the two viruses differ in a single base pair: the deduced Glu(62) of the Mos residue of the R7Delta447 Gag-tMos protein is changed to Lys(62).	Lysine	149-152	melanoma antigen	Mus musculus	118-121
11157981-3	2001	In this study we have identified a family of genes for enzymes responsible for hydroxylizing lysines in collagens as one group of likely cognate targets of PITX2 transcriptional regulation.	Lysine	93-100	paired like homeodomain 2	Homo sapiens	156-161
11239517-2	2001	There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: codons 416 GAT --&gt; GAG (Asp --&gt; Glu) and 420 ACG --&gt; AAG (Thr --&gt; Lys).	Lysine	173-176	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
11217815-2	2001	METHODS: First, the use of natural receptor for stem cell factor and transferrin receptor-targeted gene transfer using poly-L-lysine-based molecular conjugate vectors was evaluated in a panel of hematopoietic progenitor cell lines.	Lysine	119-132	transferrin	Homo sapiens	69-80
11321164-1	2001	Tissue transglutaminase forms cross-links between lysine and glutamine side-chains of polypeptide chains in a Ca2+-dependent reaction; its structural basis is still not clarified.	Lysine	50-56	transglutaminase 2	Homo sapiens	0-23
11054430-5	2001	Interestingly, nitrite concentrations as low as 12.5 and 25 microm significantly decreased MPO/H2O2)/Cl- -induced modification of apoB lysine residues, formation of N-chloramines, and increases in the relative electrophoretic mobility of LDL.	Lysine	135-141	myeloperoxidase	Homo sapiens	91-94
11297671-3	2001	In an attempt to decrease the aggregation of E.coli-derived EPO, the three asparagine residues at positions 24, 38 and 83 were mutated to lysine residues.	Lysine	138-144	erythropoietin	Homo sapiens	60-63
11013234-7	2001	The main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.	Lysine	191-197	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	32-37
11145944-9	2001	Reducing positive charges on lysine and arginine residues on HDL+E eliminated biglycan binding, suggesting an ionic interaction.	Lysine	29-35	biglycan	Homo sapiens	78-86
11013234-7	2001	The main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.	Lysine	234-240	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	32-37
11341924-0	2001	Replacement of Lys-75 of calmodulin affects its interaction with smooth muscle caldesmon.	Lysine	15-18	calmodulin 1	Homo sapiens	25-35
11042198-6	2001	Based on this model, two residues (Lys-183 and Asp-217) in the regulatory IDH1 subunit were predicted to be important in the catalytic site of IDH2.	Lysine	35-38	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	74-78
11042198-8	2001	Also based on this model, the two analogous residues (Lys-189 and Asp-222) of the catalytic IDH2 subunit were predicted to contribute to the regulatory site of IDH1.	Lysine	54-57	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	160-164
11460477-2	2001	We have characterized the lysine residues in fibrinogen to which PAI-2 is crosslinked by tissue transglutaminase and factor XIIIa.	Lysine	26-32	fibrinogen beta chain	Homo sapiens	45-55
11460480-7	2001	Thus, stromelysin-1 (MMP-3) cleaves a 55-kDa kringle 1-4 fragment, containing the lysine binding site(s) involved in cellular binding, from plasminogen and removes a 17-kDa NH2-terminal fragment, containing the cellular receptor binding site, from urokinase (u-PA).	Lysine	82-88	matrix metallopeptidase 3	Homo sapiens	6-19
11460480-7	2001	Thus, stromelysin-1 (MMP-3) cleaves a 55-kDa kringle 1-4 fragment, containing the lysine binding site(s) involved in cellular binding, from plasminogen and removes a 17-kDa NH2-terminal fragment, containing the cellular receptor binding site, from urokinase (u-PA).	Lysine	82-88	matrix metallopeptidase 3	Homo sapiens	21-26
11169624-5	2001	We have continued these studies and report that PTP1B is localized to the tips of growing neurites and that introduction of a noncatalytic mutant of PTP1B into PC12 cells results in inhibition of N-cadherin- and beta1-integrin-mediated neurite outgrowth but is without effect on neurite outgrowth on poly-L-lysine.	Lysine	300-313	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	149-154
11038348-9	2001	The decreased binding of RHA to p16(INK4a) in our cells, where the gene is transcriptionally inactive, is associated with decreased amounts of RHA that immunoprecipitate with acetylated lysine antibodies.	Lysine	186-192	Su(osk)P16	Drosophila melanogaster	32-35
11038348-9	2001	The decreased binding of RHA to p16(INK4a) in our cells, where the gene is transcriptionally inactive, is associated with decreased amounts of RHA that immunoprecipitate with acetylated lysine antibodies.	Lysine	186-192	cyclin dependent kinase inhibitor 2A	Homo sapiens	36-41
11993645-3	2001	A biopolymer membrane of poly-L-lysine confining XOD and AOD was cast on the monolayer of cytochrome c.	Lysine	25-38	cytochrome c, somatic	Homo sapiens	90-102
11313783-5	2001	To investigate the efficacy of the bystander effect in HSVtk/GCV gene therapy, the Cx 26 gene was introduced into UM-UC-3 and UM-UC-14 bladder cancer cell lines by an adenovirus poly-L-lysine conjugate using a multigenic expression plasmid that expressed both the HSVtk and Cx 26 genes.	Lysine	178-191	gap junction protein beta 2	Homo sapiens	83-88
11252719-6	2001	The CBP-associated HMT is specific for lysines 4 and 9 of histone H3, which are known to be methylated in living cells.	Lysine	39-46	CREB binding protein	Homo sapiens	4-7
11642611-8	2001	TCR transgenic T cells specific to cytochrome c peptide 88-104 acquired the capacity to respond to the low-affinity analogue at position 99 (lys--&gt;ala) if PAHA was present during their development.	Lysine	141-144	cytochrome c, somatic	Homo sapiens	35-47
11180563-5	2001	Kinetic rates for the binding of bovine pancreatic ribonuclease A (RNase A), monoacylated on its N-terminal lysine with fatty acids of 10, 12, 14, 16 or 18 carbon atoms, to phospholipids on hydrophobic sensor chips, were measured.	Lysine	108-114	ribonuclease pancreatic	Bos taurus	51-65
11180563-5	2001	Kinetic rates for the binding of bovine pancreatic ribonuclease A (RNase A), monoacylated on its N-terminal lysine with fatty acids of 10, 12, 14, 16 or 18 carbon atoms, to phospholipids on hydrophobic sensor chips, were measured.	Lysine	108-114	ribonuclease pancreatic	Bos taurus	67-74
11164277-3	2001	Concomitant incubation of a small cationic peptide (lysine(4)) with Abeta abrogated its ability to trigger the cleavage of high molecular weight kininogen, indicating that Abeta"s activity can be blocked by an inhibitory peptide.	Lysine	52-58	amyloid beta precursor protein	Homo sapiens	68-73
11135081-5	2001	The binding characteristics of IgA1 to HMCs in the presence of polycation (poly-L-lysine) or polyanion (heparin) were also investigated.	Lysine	75-88	MKKS centrosomal shuttling protein	Homo sapiens	39-43
11135081-16	2001	Preincubation with poly-L-lysine increased the binding of pIgA1 to HMCs.	Lysine	19-32	MKKS centrosomal shuttling protein	Homo sapiens	67-71
11164277-3	2001	Concomitant incubation of a small cationic peptide (lysine(4)) with Abeta abrogated its ability to trigger the cleavage of high molecular weight kininogen, indicating that Abeta"s activity can be blocked by an inhibitory peptide.	Lysine	52-58	amyloid beta precursor protein	Homo sapiens	172-177
11180537-4	2001	The deoxycholic acid was bound on substance P through the amino group at Arg-1 and/or Lys-3.	Lysine	86-89	tachykinin precursor 1	Homo sapiens	34-45
11121022-4	2000	Substitutions of sumoylated Lys residues enhanced transcriptional activity of AR without influencing its transrepressing activity.	Lysine	28-31	androgen receptor	Homo sapiens	78-80
11123933-7	2000	However, the N-termini of activated heavy membrane-bound and cytoplasmic caspase-3 are slightly different; peptide sequencing data indicate that the heavy membrane caspase-3 begins at Lys 14, whereas the cytoplasmic enzyme begins at Ser 10.	Lysine	184-187	caspase 3	Homo sapiens	73-82
11123933-7	2000	However, the N-termini of activated heavy membrane-bound and cytoplasmic caspase-3 are slightly different; peptide sequencing data indicate that the heavy membrane caspase-3 begins at Lys 14, whereas the cytoplasmic enzyme begins at Ser 10.	Lysine	184-187	caspase 3	Homo sapiens	164-173
11104695-1	2000	Deoxyhypusine synthase catalyses the NAD-dependent transfer of the butylamine moiety from the polyamine, spermidine, to a specific lysine residue of a single cellular protein, eukaryotic translation-initiation factor 5A (eIF5A) precursor.	Lysine	131-137	deoxyhypusine synthase	Homo sapiens	0-22
11121022-5	2000	Interestingly, the same Lys residues form the cores of the recently described transcriptional synergy control motifs in AR [Iniguez-Lluhi, J.	Lysine	24-27	androgen receptor	Homo sapiens	120-122
11097863-0	2000	Highly potent nociceptin analog containing the Arg-Lys triple repeat.	Lysine	51-54	prepronociceptin	Homo sapiens	14-24
11095743-11	2000	Rpd3p also appears to activate telomeric genes repressed by the silent information regulator (SIR) proteins directly, possibly by deacetylating lysine 12 of histone H4.	Lysine	144-150	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	0-5
11106777-2	2000	A fluorescent probe, fluorescein 5"-isothiocyanate (FITC), was used to modify a lysine residue of vacuolar H(+)-PPase.	Lysine	80-86	inorganic pyrophosphatase 1	Homo sapiens	112-117
11120354-3	2000	A lysine residue conserved between all DYRK kinase family members was found to be essential for the kinase function of HIPK2.	Lysine	2-8	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	39-43
11094089-0	2000	Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.	Lysine	9-15	tumor protein p53	Homo sapiens	54-57
11097863-1	2000	One of the structural characteristics of a neuropeptide nociceptin is the existence of Arg-Lys (RK) residues at positions 8-9 and 12-13; both RKs have been suggested to bind to the acidic amino acid cluster in the second extracellular loop of the seven transmembrane domain receptor ORL1.	Lysine	91-94	prepronociceptin	Homo sapiens	56-66
11106777-5	2000	A double-logarithmic plot of the apparent reaction rate constant against FITC concentration yielded a straight line with a slope of 0.89, suggesting that the alteration of a single lysine residue on the enzyme is sufficient to inhibit vacuolar H(+)-PPase.	Lysine	181-187	inorganic pyrophosphatase 1	Homo sapiens	249-254
11106777-9	2000	The enhancement of fluorescence intensity and the blue shift of the emission maximum of FITC after modification of vacuolar H(+)-PPase suggest that the FITC-labeled lysine residue is located in a relatively hydrophobic region.	Lysine	165-171	inorganic pyrophosphatase 1	Homo sapiens	129-134
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Lysine	69-72	prepronociceptin	Homo sapiens	12-22
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Lysine	89-92	prepronociceptin	Homo sapiens	12-22
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Lysine	89-92	prepronociceptin	Homo sapiens	100-110
11097863-5	2000	[Arg-Lys(14-15)]nociceptin was the first peptide analog found to be stronger than the parent nociceptin, and structure-activity studies have suggested that the incorporated Arg-Lys(14-15) interacts with either the receptor acidic amino acid cluster or the receptor aromatic amino acid residues.	Lysine	5-8	prepronociceptin	Homo sapiens	16-26
10995737-5	2000	Lysyl-tRNA synthetase aminoacylates CoA-SH with lysine, leucine, threonine, alanine, valine, and isoleucine.	Lysine	48-54	lysyl-tRNA synthetase 1	Homo sapiens	0-21
10978319-3	2000	The mutations at lysine 525 located at the C terminus of the calmodulin binding sequence of inducible nitric-oxide synthase were examined for the effects on the Ca(2+)-independent activity with chimeras containing the oxygenase or reductase domains of inducible or neuronal nitric-oxide synthases.	Lysine	17-23	calmodulin 1	Homo sapiens	61-71
10921925-6	2000	In apoE3.DMPC complexes, however, all eight lysines were resolved, and the pK(a) values were 9.2-11.1.	Lysine	44-51	apolipoprotein E	Homo sapiens	3-8
10921925-0	2000	Effects of lipid interaction on the lysine microenvironments in apolipoprotein E.	Lysine	36-42	apolipoprotein E	Homo sapiens	64-80
11063596-0	2000	pH dependence of formation of a partially unfolded state of a Lys 73 --&gt; His variant of iso-1-cytochrome c: implications for the alkaline conformational transition of cytochrome c.	Lysine	62-65	cytochrome c, somatic	Homo sapiens	97-109
11063596-0	2000	pH dependence of formation of a partially unfolded state of a Lys 73 --&gt; His variant of iso-1-cytochrome c: implications for the alkaline conformational transition of cytochrome c.	Lysine	62-65	cytochrome c, somatic	Homo sapiens	170-182
11063596-1	2000	The alkaline conformational transition of a lysine 73 --&gt; histidine variant of iso-1-cytochrome c has been studied.	Lysine	44-50	cytochrome c, somatic	Homo sapiens	88-100
10921925-8	2000	Shift reagent experiments with potassium ferricyanide showed that Lys-143 and Lys-146 were much more accessible to the ferricyanide anion in the apoE3.DMPC complex than in the lipid-free state.	Lysine	66-69	apolipoprotein E	Homo sapiens	145-150
10944517-7	2000	This difference in stop transfer activity was due to two residues that altered both the length and hydrophobicity of TM2 (Asn(49) and Lys(51) in AQP1 versus Met(48) and Leu(50) in AQP4).	Lysine	134-137	aquaporin 1 (Colton blood group)	Homo sapiens	145-149
10921925-1	2000	Lysines in apolipoprotein (apo) E are key factors in the binding of apoE to the low density lipoprotein receptor, and high affinity binding requires that apoE be associated with lipid.	Lysine	0-7	apolipoprotein E	Homo sapiens	11-33
10921925-1	2000	Lysines in apolipoprotein (apo) E are key factors in the binding of apoE to the low density lipoprotein receptor, and high affinity binding requires that apoE be associated with lipid.	Lysine	0-7	apolipoprotein E	Homo sapiens	68-72
10921925-2	2000	To gain insight into this effect, we examined the microenvironments of the eight lysines in the 22-kDa fragment of apoE3 (residues 1-191) in the lipid-free and lipid-associated states.	Lysine	81-88	apolipoprotein E	Homo sapiens	115-120
10944526-4	2000	In vitro, MyoD is acetylated both by CBP/p300 and by PCAF on two lysines located at the boundary of the DNA binding domain.	Lysine	65-72	myogenic differentiation 1	Homo sapiens	10-14
10921925-8	2000	Shift reagent experiments with potassium ferricyanide showed that Lys-143 and Lys-146 were much more accessible to the ferricyanide anion in the apoE3.DMPC complex than in the lipid-free state.	Lysine	78-81	apolipoprotein E	Homo sapiens	145-150
11060347-3	2000	There are two potential explanations for the preference of apoE7 for VLDL: lysine mutations, which occur in the major lipid-binding region (residues 244-272) of the carboxy-terminal domain of apoE7, could either directly determine the lipoprotein-binding preference or could interact with negatively charged residues in the amino-terminal domain, resulting in a domain interaction similar to that in apoE4 (interaction of Arg-61 with Glu-255), which is responsible for the apoE4 VLDL preference.	Lysine	75-81	apolipoprotein E	Homo sapiens	400-405
11137457-1	2000	Ophiobolin A, a fungal toxin that affects rice and maize, inhibits calmodulin by reacting with the lysine residues in calmodulin.	Lysine	99-105	calmodulin	Bos taurus	67-77
11137457-1	2000	Ophiobolin A, a fungal toxin that affects rice and maize, inhibits calmodulin by reacting with the lysine residues in calmodulin.	Lysine	99-105	calmodulin	Bos taurus	118-128
11137457-2	2000	Previous studies have shown that lysines 75, 77 and 148 in the calmodulin molecule were the binding sites for ophiobolin A, and that lysine 75 was the primary inhibitory site.	Lysine	33-40	calmodulin	Bos taurus	63-73
11137457-2	2000	Previous studies have shown that lysines 75, 77 and 148 in the calmodulin molecule were the binding sites for ophiobolin A, and that lysine 75 was the primary inhibitory site.	Lysine	33-39	calmodulin	Bos taurus	63-73
11137457-7	2000	It was found that when lysine 75 or 77 in the mutant calmodulin was reacted with ophiobolin A, the resulting calmodulin became a poor activator of phosphodiestease.	Lysine	23-29	calmodulin	Bos taurus	53-63
11137457-7	2000	It was found that when lysine 75 or 77 in the mutant calmodulin was reacted with ophiobolin A, the resulting calmodulin became a poor activator of phosphodiestease.	Lysine	23-29	calmodulin	Bos taurus	109-119
11137457-8	2000	These results provide further evidence that lysine 75 in calmodulin is the primary inhibitory site for ophiobolin A.	Lysine	44-50	calmodulin	Bos taurus	57-67
11029577-4	2000	Amyloid-beta peptide (Abeta) has a cluster of basic amino acids at the N-terminus (residues 13-16, His-His-Gln-Lys), which are considered critical for glycosaminoglycan interactions.	Lysine	111-114	amyloid beta precursor protein	Homo sapiens	22-27
11029577-8	2000	The results demonstrate that the His-His-Gln-Lys region of Abeta, and in particular His13, is an important structural domain, as Ala substitution produces a dysfunctional folding mutant.	Lysine	45-48	amyloid beta precursor protein	Homo sapiens	59-64
11060347-3	2000	There are two potential explanations for the preference of apoE7 for VLDL: lysine mutations, which occur in the major lipid-binding region (residues 244-272) of the carboxy-terminal domain of apoE7, could either directly determine the lipoprotein-binding preference or could interact with negatively charged residues in the amino-terminal domain, resulting in a domain interaction similar to that in apoE4 (interaction of Arg-61 with Glu-255), which is responsible for the apoE4 VLDL preference.	Lysine	75-81	apolipoprotein E	Homo sapiens	473-478
11060347-5	2000	ApoE7 and both mutants displayed a higher preference for the emulsion particles than did apoE3, indicating that the carboxy-terminal lysine mutations in apoE7 are directly responsible for its preference for VLDL.	Lysine	133-139	apolipoprotein E	Homo sapiens	89-94
11046142-0	2000	Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.	Lysine	20-26	tumor protein p53	Homo sapiens	43-46
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Lysine	25-31	tumor protein p53	Homo sapiens	100-103
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Lysine	25-31	tumor protein p53	Homo sapiens	124-127
11046142-8	2000	Those differences are also manifest in HeLa cells which express the human papillomavirus E6 protein, suggesting that p53 C-terminal lysine residues are also implicated in E6-AP-mediated ubiquitination.	Lysine	132-138	tumor protein p53	Homo sapiens	117-120
11046142-9	2000	These data suggest that p53 C-terminal lysine residues are the main sites of ubiquitin ligation, which target p53 for proteasome-mediated degradation.	Lysine	39-45	tumor protein p53	Homo sapiens	24-27
11046142-9	2000	These data suggest that p53 C-terminal lysine residues are the main sites of ubiquitin ligation, which target p53 for proteasome-mediated degradation.	Lysine	39-45	tumor protein p53	Homo sapiens	110-113
11046145-4	2000	Interestingly, CBP and PCAF acetylate CIITA at lysine residues within a nuclear localization signal.	Lysine	47-53	CREB binding protein	Homo sapiens	15-18
10915779-2	2000	Within this region of alpha(1S), a cluster of basic residues, Arg(681)-Lys(685), was previously reported to be indispensable for the activation of RyR1 in microsomal preparations and lipid bilayers.	Lysine	71-74	ryanodine receptor 1	Homo sapiens	147-151
22062075-4	2000	The aminopeptidase exhibited maximal activity against Met-, Lys-, Ala-, and Leu-7-amido-4-methyl-coumarin (-AMC), while Pro-AMC was not hydrolyzed.	Lysine	60-63	carboxypeptidase Q	Homo sapiens	4-18
10906670-0	2000	Time course of transforming growth factor-beta(1) (TGF-beta(1)) mRNA expression in the host reaction to alginate-poly-L-lysine microcapsules following implantations into rat epididymal fat pads.	Lysine	113-126	transforming growth factor, beta 1	Rattus norvegicus	15-49
10906670-0	2000	Time course of transforming growth factor-beta(1) (TGF-beta(1)) mRNA expression in the host reaction to alginate-poly-L-lysine microcapsules following implantations into rat epididymal fat pads.	Lysine	113-126	transforming growth factor, beta 1	Rattus norvegicus	51-62
11015196-6	2000	In addition, we demonstrate that some of the lysines in this alpha-helical region in actophorin are implicated in PIP(2) binding.	Lysine	45-52	prolactin induced protein	Homo sapiens	114-117
11013299-8	2000	Similar results were obtained by using a recombinant expression system for apo[a]: addition of a 4-fold molar excess of either LDL or fibronectin to conditioned medium containing metabolically labeled recombinant apo[a] reduced the Lys(+) fraction by 49 and 23%, respectively.	Lysine	232-235	fibronectin 1	Homo sapiens	134-145
11013299-9	2000	Taken together, our data suggest that the lysine-binding heterogeneity of plasma Lp[a] is not primarily an intrinsic property of the lipoprotein, but rather results in large part from its ability to noncovalently associate with abundant plasma components such as LDL and fibronectin.	Lysine	42-48	fibronectin 1	Homo sapiens	271-282
10974387-3	2000	Interleukin-6 (IL-6) was covalently conjugated via the formation of amino bonds between the lysine amino groups of IL-6 and PVP.	Lysine	92-98	interleukin 6	Mus musculus	0-13
10862775-6	2000	The results parallel the alanine scanning mutagenesis data, i.e. heparin binding to the alpha1(V) chain involved Arg(912), Arg(918), and Arg(921) and two additional neighboring basic residues, Lys(905) and Arg(909).	Lysine	193-196	collagen type V alpha 1 chain	Homo sapiens	88-97
10889192-5	2000	Inhibition of plasminogen and angiostatin binding to NG2 by 6-aminohexanoic acid suggests that lysine binding sites are involved in kringle interaction with NG2.	Lysine	95-101	chondroitin sulfate proteoglycan 4	Homo sapiens	53-56
10889192-5	2000	Inhibition of plasminogen and angiostatin binding to NG2 by 6-aminohexanoic acid suggests that lysine binding sites are involved in kringle interaction with NG2.	Lysine	95-101	chondroitin sulfate proteoglycan 4	Homo sapiens	157-160
10996851-7	2000	The PMA-induced ERK phosphorylation was inhibited by Ro 31-8220, LY 379196, rottlerin, and PD 98059, but unaffected by SB 203580 and wortmannin.	Lysine	65-67	mitogen-activated protein kinase 1	Homo sapiens	16-19
10973820-3	2000	To this goal, the analogues were designed to increase only net positively charge by Lys-substitution of positions 2, 9, 13, or 16 at the hydrophilic helix face of CRAMP-18 without any change at the hydrophobic helix face.	Lysine	84-87	cathelicidin antimicrobial peptide	Homo sapiens	163-168
10973820-4	2000	In particular, Lys-substitution (K(2)-CRAMP-18) of position 2 in CRAMP-18 induced the enhanced antibiotic activity without any increase in hemolysis.	Lysine	15-18	cathelicidin antimicrobial peptide	Homo sapiens	38-43
10973820-4	2000	In particular, Lys-substitution (K(2)-CRAMP-18) of position 2 in CRAMP-18 induced the enhanced antibiotic activity without any increase in hemolysis.	Lysine	15-18	cathelicidin antimicrobial peptide	Homo sapiens	65-70
10974387-3	2000	Interleukin-6 (IL-6) was covalently conjugated via the formation of amino bonds between the lysine amino groups of IL-6 and PVP.	Lysine	92-98	interleukin 6	Mus musculus	15-19
10974387-3	2000	Interleukin-6 (IL-6) was covalently conjugated via the formation of amino bonds between the lysine amino groups of IL-6 and PVP.	Lysine	92-98	interleukin 6	Mus musculus	115-119
10893241-5	2000	Site-directed mutagenesis showed that Lys-521 and Asn-534 were required for optimum calmodulin binding and that restoration of these amino acids to the counterpart PTPepsilon sequence could confer calmodulin binding.	Lysine	38-41	calmodulin 1	Homo sapiens	84-94
10878019-3	2000	We mutated the important contact sites Glu-89, Asn-90, and Asn-130 in RGS16 to lysine, aspartate, and alanine, respectively.	Lysine	79-85	regulator of G-protein signaling 16	Rattus norvegicus	70-75
10878019-7	2000	As Glu-89 in RGS16 is interacting with Lys-210 in Galpha(i1), this lysine was changed to glutamate for compensation.	Lysine	39-42	regulator of G-protein signaling 16	Rattus norvegicus	13-18
10878019-7	2000	As Glu-89 in RGS16 is interacting with Lys-210 in Galpha(i1), this lysine was changed to glutamate for compensation.	Lysine	67-73	regulator of G-protein signaling 16	Rattus norvegicus	13-18
10978526-5	2000	In addition, NBC4 lacks the lysine-rich C-terminus of NBC1 with which it is most homologous.	Lysine	28-34	solute carrier family 4 member 5	Homo sapiens	13-17
10978526-5	2000	In addition, NBC4 lacks the lysine-rich C-terminus of NBC1 with which it is most homologous.	Lysine	28-34	solute carrier family 4 member 4	Homo sapiens	54-58
10974387-4	2000	PVP-conjugated IL-6, in which 60% of the fourteen lysine amino groups of IL-6 were estimated to be coupled with PVP (M-PVP-IL-6), showed more than 50-fold greater thrombopoietic potency in vivo than native IL-6.	Lysine	50-56	interleukin 6	Mus musculus	15-19
11030562-4	2000	However, expression of a cDNA encoding a proinsulin-like molecule with deletion of threonine(B30) as a fusion protein with the S. cerevisiae alpha-factor prepro-peptide (leader), followed either by replacement of the human proinsulin C-peptide with a small C-peptide (e.g. AAK), or by direct fusion of lysine(B29) to glycine(A1), results in the efficient secretion of folded single-chain proinsulin-like molecules to the culture supernatant.	Lysine	302-308	insulin	Homo sapiens	41-51
10974387-4	2000	PVP-conjugated IL-6, in which 60% of the fourteen lysine amino groups of IL-6 were estimated to be coupled with PVP (M-PVP-IL-6), showed more than 50-fold greater thrombopoietic potency in vivo than native IL-6.	Lysine	50-56	interleukin 6	Mus musculus	73-77
10974387-4	2000	PVP-conjugated IL-6, in which 60% of the fourteen lysine amino groups of IL-6 were estimated to be coupled with PVP (M-PVP-IL-6), showed more than 50-fold greater thrombopoietic potency in vivo than native IL-6.	Lysine	50-56	interleukin 6	Mus musculus	73-77
10974387-4	2000	PVP-conjugated IL-6, in which 60% of the fourteen lysine amino groups of IL-6 were estimated to be coupled with PVP (M-PVP-IL-6), showed more than 50-fold greater thrombopoietic potency in vivo than native IL-6.	Lysine	50-56	interleukin 6	Mus musculus	73-77
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Lysine	57-63	erythropoietin	Homo sapiens	200-203
10956015-0	2000	Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met(145)-Lys(148).	Lysine	98-101	calmodulin 1	Homo sapiens	56-66
10987285-4	2000	Despite the recent biochemical evidence that maspin specifically inhibits tissue-type plasminogen activator that is associated with fibrinogen or poly-L-lysine, the molecular mechanism underlying the tumor-suppressive effect of maspin remains elusive.	Lysine	146-159	plasminogen activator, tissue type	Homo sapiens	74-107
10958685-0	2000	Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.	Lysine	122-129	histone deacetylase 2	Homo sapiens	39-60
10958685-0	2000	Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.	Lysine	122-129	interleukin 1 beta	Homo sapiens	70-87
10816585-1	2000	In this study, we identified lysine residues in the fibrinogen Aalpha chain that serve as substrates during transglutaminase (TG)-mediated cross-linking of plasminogen activator inhibitor 2 (PAI-2).	Lysine	29-35	fibrinogen beta chain	Homo sapiens	52-62
10833508-9	2000	The insensitive Kir3.2 was made sensitive to BDNF by adding a tyrosine (D41Y) and a lysine (P32K) upstream to generate a phosphorylation site motif analogous to that present in Kir3.4.	Lysine	84-90	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	16-22
10827082-7	2000	The amino acid substitutions in this chimera suggest that Ser(50) in the first transmembrane domain of mIP confers the broad ligand recognition of mIP and that Lys(75) and Leu(83) in the second transmembrane domain of mDP confer the high affinity to PGD(2) and the strict specificity of ligand binding of mDP, respectively.	Lysine	160-163	major intrinsic protein of lens fiber	Mus musculus	103-106
10926853-5	2000	A site-directed mutagenesis analysis of the binding region has revealed the critical importance of a single lysine residue (lysine 65 in human CRP1).	Lysine	108-114	cysteine rich protein 1	Homo sapiens	143-147
10926853-5	2000	A site-directed mutagenesis analysis of the binding region has revealed the critical importance of a single lysine residue (lysine 65 in human CRP1).	Lysine	124-130	cysteine rich protein 1	Homo sapiens	143-147
10926853-7	2000	The critical lysine residue localizes within a short alpha-helix, raising the possibility that mutagenesis-induced alterations in alpha-actinin-binding capacity might be attributed to the disruption of a key structural element.	Lysine	13-19	actinin alpha 1	Homo sapiens	130-143
10816596-7	2000	Sulfation at 2-O- and 6-O-positions was moreover a prerequisite for binding of heparin to a lysine-rich peptide corresponding to amino acids 160-177 in the extracellular domain of FGFR-1.	Lysine	92-98	fibroblast growth factor receptor 1	Gallus gallus	180-186
10816585-3	2000	A 30-residue peptide containing Lys-303 specifically competed with fibrinogen for cross-linking to alpha(2)-AP but not for cross-linking to PAI-2.	Lysine	32-35	fibrinogen beta chain	Homo sapiens	67-77
10823834-8	2000	Cells plated on poly-l-lysine (to prevent the formation of focal adhesions) showed activation only of JNK and p38.	Lysine	16-29	mitogen-activated protein kinase 8	Homo sapiens	102-105
10949293-3	2000	Here we show that human SUV39H1 and murine Suv39h1--mammalian homologues of Drosophila Su(var)3-9 and of Schizosaccharomyces pombe clr4--encode histone H3-specific methyltransferases that selectively methylate lysine 9 of the amino terminus of histone H3 in vitro.	Lysine	210-216	SUV39H1 histone lysine methyltransferase	Homo sapiens	24-31
10823834-8	2000	Cells plated on poly-l-lysine (to prevent the formation of focal adhesions) showed activation only of JNK and p38.	Lysine	16-29	mitogen-activated protein kinase 14	Homo sapiens	110-113
10924106-8	2000	A novel feature of BAF"s HhH motif is the occupation of the metal binding site by the epsilon-amino group of Lys 6, providing an alternative means of sequestering positive charge.	Lysine	109-112	BAF nuclear assembly factor 1	Homo sapiens	19-22
10823834-9	2000	ERK activation was partially restored by incubating cells plated on poly-l-lysine with collagen-coated beads before IL-1 stimulation.	Lysine	68-81	mitogen-activated protein kinase 1	Homo sapiens	0-3
10975256-1	2000	The Lys14 regulatory protein of Saccharomyces cerevisiae activates the expression of the LYS genes involved in the lysine biosynthetic pathway.	Lysine	89-92	Lys14p	Saccharomyces cerevisiae S288C	4-9
10956059-4	2000	Micro-LC/tandem MS analyses of tryptic as well as V8 protease digests identified one of the adducts to albumin as a urea resulting from intramolecular bridging of lysine residues 195 and 199.	Lysine	163-169	albumin	Homo sapiens	103-110
10801840-5	2000	Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor.	Lysine	205-208	vasoactive intestinal peptide	Homo sapiens	54-57
10801840-5	2000	Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor.	Lysine	214-217	vasoactive intestinal peptide	Homo sapiens	54-57
10975256-1	2000	The Lys14 regulatory protein of Saccharomyces cerevisiae activates the expression of the LYS genes involved in the lysine biosynthetic pathway.	Lysine	115-121	Lys14p	Saccharomyces cerevisiae S288C	4-9
10891493-6	2000	PCAF binds to the E1B 55-kDa protein and to a region near the C terminus of p53 encompassing Lys-320, the specific PCAF acetylation site.	Lysine	93-96	tumor protein p53	Homo sapiens	76-79
10889020-2	2000	The present study reports a third, novel "contact site" between hPTH1-Rc and Lys(27) of PTH(1-34).	Lysine	77-80	parathyroid hormone	Homo sapiens	65-68
10947940-5	2000	In rat blood, peptides with carboxy-terminal lysine or arginine residues protected the phage against complement-mediated inactivation by binding C-reactive protein.	Lysine	45-51	C-reactive protein	Rattus norvegicus	145-163
10959688-0	2000	Type 2M vWD resulting from a lysine deletion within a four lysine residue repeat in the A1 loop of von Willebrand factor.	Lysine	29-35	von Willebrand factor	Homo sapiens	99-120
10959688-0	2000	Type 2M vWD resulting from a lysine deletion within a four lysine residue repeat in the A1 loop of von Willebrand factor.	Lysine	59-65	von Willebrand factor	Homo sapiens	99-120
10959688-3	2000	We report here the identification, in two unrelated families from the UK and Algeria, of an in-frame 3 bp deletion, at the heterozygous state, resulting in the deletion of a lysine residue within a four lysine repeat at position 642-645 of the mature vWF subunit (del K 1405-1408 in pre-pro vWF).	Lysine	174-180	von Willebrand factor	Homo sapiens	251-254
10959688-3	2000	We report here the identification, in two unrelated families from the UK and Algeria, of an in-frame 3 bp deletion, at the heterozygous state, resulting in the deletion of a lysine residue within a four lysine repeat at position 642-645 of the mature vWF subunit (del K 1405-1408 in pre-pro vWF).	Lysine	174-180	von Willebrand factor	Homo sapiens	291-294
10959688-3	2000	We report here the identification, in two unrelated families from the UK and Algeria, of an in-frame 3 bp deletion, at the heterozygous state, resulting in the deletion of a lysine residue within a four lysine repeat at position 642-645 of the mature vWF subunit (del K 1405-1408 in pre-pro vWF).	Lysine	203-209	von Willebrand factor	Homo sapiens	251-254
10959688-3	2000	We report here the identification, in two unrelated families from the UK and Algeria, of an in-frame 3 bp deletion, at the heterozygous state, resulting in the deletion of a lysine residue within a four lysine repeat at position 642-645 of the mature vWF subunit (del K 1405-1408 in pre-pro vWF).	Lysine	203-209	von Willebrand factor	Homo sapiens	291-294
10935543-3	2000	A nonconservative asparagine to lysine substitution in AR residue 727 was encountered in a phenotypically normal man with subfertility and depressed spermatogenesis.	Lysine	32-38	androgen receptor	Homo sapiens	55-57
10889020-0	2000	Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor.	Lysine	116-119	parathyroid hormone	Homo sapiens	41-60
10889020-0	2000	Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor.	Lysine	116-119	parathyroid hormone	Homo sapiens	62-65
10889020-0	2000	Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor.	Lysine	116-119	parathyroid hormone	Homo sapiens	67-71
10889020-0	2000	Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor.	Lysine	116-119	parathyroid hormone 1 receptor	Homo sapiens	67-80
10889020-4	2000	The photoreactive PTH(1-34) analogue K27 contains a benzophenone (BP) moiety on Lys(27).	Lysine	80-83	parathyroid hormone	Homo sapiens	18-21
10889020-12	2000	Revealing proximity of Lys(27) (in PTH) to L(261) (in hPTH1-Rc) provides additional insight into the nature of the ligand-receptor bimolecular interface and clearly illustrates that the extracellular loops of the receptor contribute to the specificity of the PTH-PTH1-Rc interaction.	Lysine	23-26	parathyroid hormone	Homo sapiens	35-38
10889020-12	2000	Revealing proximity of Lys(27) (in PTH) to L(261) (in hPTH1-Rc) provides additional insight into the nature of the ligand-receptor bimolecular interface and clearly illustrates that the extracellular loops of the receptor contribute to the specificity of the PTH-PTH1-Rc interaction.	Lysine	23-26	parathyroid hormone	Homo sapiens	55-58
10889020-12	2000	Revealing proximity of Lys(27) (in PTH) to L(261) (in hPTH1-Rc) provides additional insight into the nature of the ligand-receptor bimolecular interface and clearly illustrates that the extracellular loops of the receptor contribute to the specificity of the PTH-PTH1-Rc interaction.	Lysine	23-26	parathyroid hormone	Homo sapiens	55-59
10889021-4	2000	Centrally located in the second helix is L(261), found to cross-link to Lys(27) of parathyroid hormone, PTH(1-34) [Greenberg, Z., Bisello, A., Mierke, D. F., Rosenblatt, M., and Chorev, M. (2000) Biochemistry 39, 8142-8152].	Lysine	72-75	parathyroid hormone	Homo sapiens	104-107
10910364-6	2000	p53 is acetylated at lysine 382 upon Ras expression, an event that is essential for its biological function.	Lysine	21-27	tumor protein p53	Homo sapiens	0-3
10891339-2	2000	For identification, site-directed mutants at lysines of FucT-IV and -VII were prepared and tested.	Lysine	45-52	fucosyltransferase 4	Homo sapiens	56-72
10904103-5	2000	The role of the protein moiety was evaluated by chemically modifying positively charged apoB residues (Lys, Arg, and Tyr) via copper-induced oxidation, cyclohexanedione, and tetranitromethane, respectively.	Lysine	103-106	apolipoprotein B	Homo sapiens	88-92
10777485-7	2000	We demonstrate that although ry(+)LAT1-mediated transport of [(14)C]l-leucine was accompanied by the cotransport of (22)Na(+), that of [(14)C]l-lysine was not.	Lysine	142-150	solute carrier family 7 member 5 L homeolog	Xenopus laevis	34-38
10866806-1	2000	Actin ADP-ribosylated at arginine 177 is unable to hydrolyze ATP, and the R177 side chain is in a position similar to that of the catalytically essential lysine 71 in heat shock cognate protein Hsc70, another member of the actin-fold family of proteins.	Lysine	154-160	actin	Saccharomyces cerevisiae S288C	0-5
10728833-12	2000	Histidine alkylation with p-bromophenacyl bromide and lysine acetylation with acetic anhydride, abolished both indirect hemolytic and myotoxic activities of LM-PLA2.	Lysine	54-60	phospholipase A2, group V	Mus musculus	160-164
10779504-3	2000	p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-terminal to the zinc finger DNA-binding domain.	Lysine	92-98	androgen receptor	Homo sapiens	67-69
10918489-3	2000	An HveA cDNA from CLL cells was found to encode Arg--&gt;Lys and Val--&gt;Iso substitutions at amino acids 17 and 241, respectively.	Lysine	57-60	TNF receptor superfamily member 14	Homo sapiens	3-7
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Lysine	10-17	apolipoprotein E	Homo sapiens	62-84
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Lysine	10-17	apolipoprotein E	Homo sapiens	125-129
10884290-6	2000	This reduction corresponds to a decrease in free energy of binding of approximately 600 cal/mol, consistent with the elimination of a hydrogen-bonded ion pair (salt bridge) between a lysine on apoE and an acidic residue on the LDLR.	Lysine	183-189	apolipoprotein E	Homo sapiens	193-197
10851020-3	2000	Sequence comparison revealed two pairs of lysine residues that are highly conserved in M-CK but are not present in B-CK.	Lysine	42-48	creatine kinase, M-type	Homo sapiens	87-91
10766755-0	2000	Structural requirements for N-trimethylation of lysine 115 of calmodulin.	Lysine	48-54	calmodulin 1	Homo sapiens	62-72
10766755-1	2000	Calmodulin is trimethylated at lysine 115 by a highly specific methyltransferase that utilizes S-adenosylmethionine as a co-substrate.	Lysine	31-37	calmodulin 1	Homo sapiens	0-10
10751404-7	2000	We also found that a conserved Lys residue required for PP5 binding to hsp90 was critical for the binding of FKBP52 but not for the binding of Hop to hsp90.	Lysine	31-34	FKBP prolyl isomerase 4	Homo sapiens	109-115
10764768-3	2000	Recently, site-directed mutagenesis studies of FAAH have targeted a limited number of conserved residues in the amidase signature sequence of the enzyme, identifying Ser-241 as the catalytic nucleophile and Lys-142 as an acid/base catalyst.	Lysine	207-210	fatty acid amide hydrolase	Homo sapiens	47-51
10945337-6	2000	The putative polypeptide is rich in lysine (K), glutamic acid (E) and aspartic acid (D), which constitute up to 70% of total amino acids, and was therefore designated as KED.	Lysine	36-42	DNA ligase 1-like	Nicotiana tabacum	170-173
10856268-2	2000	The in vitro and in vivo inhibitory potency of omapatrilat and the specific ACE inhibitor fosinopril toward the 2 active sites of ACE (called N- and C-domains) was investigated with the use of 3 substrates: angiotensin I, which is equally cleaved by the 2 ACE domains; hippuryl-histidyl-leucine, specific synthetic substrate of the C-domain in high- salt conditions; and a newly synthesized specific substrate of the N-domain designed by acetylating the lysine residue of AcSDKP.	Lysine	454-460	angiotensin I converting enzyme	Homo sapiens	130-133
10856268-2	2000	The in vitro and in vivo inhibitory potency of omapatrilat and the specific ACE inhibitor fosinopril toward the 2 active sites of ACE (called N- and C-domains) was investigated with the use of 3 substrates: angiotensin I, which is equally cleaved by the 2 ACE domains; hippuryl-histidyl-leucine, specific synthetic substrate of the C-domain in high- salt conditions; and a newly synthesized specific substrate of the N-domain designed by acetylating the lysine residue of AcSDKP.	Lysine	454-460	angiotensin I converting enzyme	Homo sapiens	130-133
10828094-9	2000	The binding of LDL to Lp[a]/apo[a] was inhibited by L-proline and lysine analogs, which are known to inhibit the non-covalent association between apo[a] and apoB.	Lysine	66-72	apolipoprotein B	Homo sapiens	157-161
10825373-4	2000	The NK(2) receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK(1) and NK(3) receptor-selective agonists, [Sar(9), Met(O(2))(11)]SP and [N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors.	Lysine	39-42	tachykinin precursor 1	Homo sapiens	65-68
10825373-4	2000	The NK(2) receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK(1) and NK(3) receptor-selective agonists, [Sar(9), Met(O(2))(11)]SP and [N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors.	Lysine	39-42	tachykinin precursor 1	Homo sapiens	219-221
10851091-4	2000	Within the INK4 family, this regulatory mode appears restricted to p19INK4d whose ubiquitination was dependent on the integrity of lysine 62, and binding to CDK4.	Lysine	131-137	cyclin dependent kinase inhibitor 2A	Homo sapiens	11-15
10825373-5	2000	The NK(2) receptor-selective antagonist, SR48968, produced concentration-related rightward shift in the log concentration curve to [Lys(5), MeLeu(9), Nle(10)]NKA(4-10).	Lysine	132-135	tachykinin precursor 1	Homo sapiens	158-161
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Lysine	115-118	thrombopoietin	Homo sapiens	29-32
10872807-4	2000	Analysis of point mutants within this loop region of PR65 identify lysine 416 as a residue critical for interaction with HSF2.	Lysine	67-73	heat shock transcription factor 2	Homo sapiens	121-125
10872807-6	2000	These results suggest that HSF2"s ability to interfere with catalytic subunit binding to PR65 is due to competition between HSF2 and catalytic subunit for at least one amino acid residue of PR65, lysine 416.	Lysine	196-202	heat shock transcription factor 2	Homo sapiens	27-31
10872807-6	2000	These results suggest that HSF2"s ability to interfere with catalytic subunit binding to PR65 is due to competition between HSF2 and catalytic subunit for at least one amino acid residue of PR65, lysine 416.	Lysine	196-202	heat shock transcription factor 2	Homo sapiens	124-128
10850803-7	2000	Substitutions of the lysine at equivalent positions in two other inhibitory serpins, human alpha1-antichymotrypsin and human antithrombin III, also increased stability and decreased inhibitory activity toward alpha-chymotrypsin and thrombin, respectively.	Lysine	21-27	coagulation factor II, thrombin	Homo sapiens	129-137
10820004-2	2000	We have investigated the structural consequences of the insertion of the Lys-Thr-Ser (KTS) sequence by preparing recombinant protein constructs of the four zinc finger DNA-binding domain of WT1 corresponding to the two isoforms with (+KTS) and without (-KTS) the insertion, which is located in the linker region between the third and fourth zinc fingers.	Lysine	73-76	WT1 transcription factor	Homo sapiens	190-193
10788439-9	2000	The SUMO-1 attachment site in p53 (Lys-386) resides within a region known to regulate the DNA binding activity of the protein.	Lysine	35-38	tumor protein p53	Homo sapiens	30-33
10819990-9	2000	We hypothesized that the area of Src that binds the Y + 3 residue contains either a positively charged lysine or an arginine, capable of ionic interactions with glutamic acid or cation-pi interactions with phenylalanine.	Lysine	103-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-36
10879487-1	2000	A synthetic gene encoding a single chain human insulin precursor [B-chain (1-29)-A-chain] linked to the C-terminal lysine of human epidermal growth factor (1-28) (EGF-SCI) was constructed.	Lysine	115-121	insulin	Homo sapiens	47-54
10852646-1	2000	UNLABELLED: The ACE inhibitor lisinopril is a lysine derivative of enalaprilat, the active metabolite of enalapril.	Lysine	46-52	angiotensin I converting enzyme	Homo sapiens	16-19
10787443-8	2000	We postulate that some oxidized phospholipids containing fatty acid aldehydes at the sn-2 position bind to lysine residues of apoB while others remain unreacted within the lipid phase.	Lysine	107-113	apolipoprotein B	Homo sapiens	126-130
10788472-6	2000	In addition to this domain structure, HB-GAM contains the N- and C-terminal lysine-rich sequences that lack a detectable structure and appear to form random coils.	Lysine	76-82	pleiotrophin	Homo sapiens	38-44
10783828-2	2000	The novel resistance modifying agents PSC 833, 280-446, and LY 335979 are primarily targeted at inhibition of Pgp, and their MRP inhibitory potential is largely unknown.	Lysine	60-62	ATP binding cassette subfamily B member 1	Homo sapiens	110-113
10753907-11	2000	The binding of botrocetin also activates the nearby VWF-binding site for GPIb that involves Lys(599) on helix 3.	Lysine	92-95	von Willebrand factor	Homo sapiens	52-55
11003924-0	2000	[Insulin Lispro (Lys B28, Pro B29) treatment in adolescents and young people with type 1 diabetes].	Lysine	17-20	insulin	Homo sapiens	1-8
11003924-1	2000	BACKGROUND: The human insulin analogue, Lispro (Lys B28, Pro B29), is more similar to normal pancreatic insulin response to ingestion.	Lysine	48-51	insulin	Homo sapiens	22-29
10830491-4	2000	Tryptic peptide analysis of the conjugate showed that Lys 33 in lysozyme is the residue mainly modified with mPEG-COONSu.	Lysine	54-57	lysozyme	Homo sapiens	64-72
10852380-6	2000	This implies that peptides carrying HLA-A*1101 anchor residues (Val, Ile, Phe or Tyr at P2 and Lys at the C-terminus) can bind to HLA-A*3303.	Lysine	95-98	major histocompatibility complex, class I, A	Homo sapiens	36-41
10784191-9	2000	Increasing lysine intake increased serum urea nitrogen (SUN) and postprandial insulin concentrations (P &lt; .05) during lactation but had no effect on plasma glucose concentrations (P &gt; .20).	Lysine	11-17	insulin	Homo sapiens	78-85
10784191-12	2000	Results indicate that, compared with medium lysine intake, low lysine intake increased muscle protein degradation and decreased concentrations of insulin, SUN, and estradiol and LH pulsatility.	Lysine	63-69	insulin	Homo sapiens	146-153
10784191-13	2000	In contrast, high lysine (protein) intake increased SUN, insulin, and IGF-I, but did not increase secretion of estradiol and LH compared with medium lysine intake.	Lysine	18-24	insulin	Homo sapiens	57-64
10784191-13	2000	In contrast, high lysine (protein) intake increased SUN, insulin, and IGF-I, but did not increase secretion of estradiol and LH compared with medium lysine intake.	Lysine	18-24	insulin like growth factor 1	Homo sapiens	70-75
10882110-2	2000	Here, it is shown that CBP can acetylate hepatocyte nuclear factor-4 (HNF-4), a member of the nuclear hormone receptor family, at lysine residues within the nuclear localization sequence.	Lysine	130-136	hepatocyte nuclear factor 4 alpha	Homo sapiens	70-75
10882110-2	2000	Here, it is shown that CBP can acetylate hepatocyte nuclear factor-4 (HNF-4), a member of the nuclear hormone receptor family, at lysine residues within the nuclear localization sequence.	Lysine	130-136	CREB binding protein	Homo sapiens	23-26
10852380-9	2000	The preference for Arg and Lys at the C-terminus by HLA-A*1101 and HLA-A*3303 respectively may be due to sequences of three residues (70, 97 and 114) forming the F-pocket of these HLA class I molecules.	Lysine	27-30	major histocompatibility complex, class I, A	Homo sapiens	52-57
10852380-9	2000	The preference for Arg and Lys at the C-terminus by HLA-A*1101 and HLA-A*3303 respectively may be due to sequences of three residues (70, 97 and 114) forming the F-pocket of these HLA class I molecules.	Lysine	27-30	major histocompatibility complex, class I, A	Homo sapiens	67-72
10852380-6	2000	This implies that peptides carrying HLA-A*1101 anchor residues (Val, Ile, Phe or Tyr at P2 and Lys at the C-terminus) can bind to HLA-A*3303.	Lysine	95-98	major histocompatibility complex, class I, A	Homo sapiens	130-135
10852380-8	2000	Thus, Arg at the C-terminus is much stronger anchor for HLA-A*3303 than Lys.	Lysine	72-75	major histocompatibility complex, class I, A	Homo sapiens	56-61
10706377-5	2000	The catalytically important residues (Arg-39, Ser-136, Tyr-149 and Lys-153) of MLCR were found in the peptide sequences of RHAR, despite the low residue identities between the two enzymes.	Lysine	67-70	carbonyl reductase 2	Mus musculus	79-83
10715115-8	2000	While His 19 of MGS and Lys 13 of TIM appear on the opposite face of the 2PG carboxylate plane, their relative location to the 2PG molecule is quite different, suggesting that they probably have different functions.	Lysine	24-27	triosephosphate isomerase 1	Homo sapiens	34-37
10694407-11	2000	The Lys(60F) side chain of thrombin moved significantly and formed a large nonpolar S1" subsite to accommodate the bulky P1" residue.	Lysine	4-7	coagulation factor II, thrombin	Homo sapiens	27-35
10677350-8	2000	Finally, mutation of a specific lysine residue in ZRT1 blocks both ubiquitination and endocytosis.	Lysine	32-38	high-affinity Zn(2+) transporter ZRT1	Saccharomyces cerevisiae S288C	50-54
10818267-13	2000	The selectivity observed with M. sexta particulates indicates a preferential involvement of oligobasic lysine-rich C-terminal sequences of IFN-gamma, while large insect tissue-related affinity differences point to involvement of diverse oligoacidic sequences in binding to protocerebrum and hemolymph sites.	Lysine	103-109	interferon gamma	Homo sapiens	139-148
10746547-5	2000	Administration of either of two NOS inhibitors, aminoguanidine (AG) or L-lysine,N6-1-iminoethyl-dihydrochloride, appears to abrogate in part the tumor growth inhibition observed when IL-10 is overexpressed as a transgene in two murine mammary tumor cell lines.	Lysine	71-79	interleukin 10	Mus musculus	183-188
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Lysine	197-204	transferrin	Homo sapiens	51-62
10684598-3	2000	Possible explanations for the release of iron from transferrin at low pH include protonation of a histidine ligand and the existence of a pH-sensitive "trigger" involving a hydrogen-bonded pair of lysines in the N-lobe of transferrin.	Lysine	197-204	transferrin	Homo sapiens	222-233
10660620-6	2000	Polymerase chain reaction amplification of cDNA in combination with genomic sequence analysis revealed a second gene, PILRbeta, coding for a putative activating receptor as suggested by a truncated cytoplasmic tail and a charged lysine residue in its transmembrane region.	Lysine	229-235	paired immunoglobin like type 2 receptor beta	Homo sapiens	118-126
10664464-3	2000	Arabidopsis Hcf136 is targeted exclusively by the Tat pathway in pea chloroplasts and no Sec-dependent transport is evident even when the twin-arginine is replaced by twin-lysine.	Lysine	172-178	photosystem II stability/assembly factor, chloroplast (HCF136)	Arabidopsis thaliana	12-18
10692330-1	2000	Myosin subfragment 1 (S1) can be specifically modified at Lys-553 with the fluorescent probe FHS (6-[fluorescein-5(and 6)-carboxamido]hexanoic acid succinimidyl ester) (Bertrand, R., J. Derancourt, and R. Kassab.	Lysine	58-61	proteasome 26S subunit, non-ATPase 1	Homo sapiens	0-24
18944613-9	2000	The amino acid positions 73, 102, 109, and 149 of the CP gene, where lysine, serine, arginine, and aspartic acid reside, respectively, were uniquely conserved for genotype I Taiwan isolates.	Lysine	69-75	golgi phosphoprotein 3	Homo sapiens	54-56
10660554-10	2000	We also show that the dilysine motif in OST48 functions as an ER localization motif because OST48 in which the two lysine residues are replaced by serine (OST48ss) is no longer retained in the ER and is found instead also at the plasma membrane.	Lysine	24-30	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	40-45
10660554-10	2000	We also show that the dilysine motif in OST48 functions as an ER localization motif because OST48 in which the two lysine residues are replaced by serine (OST48ss) is no longer retained in the ER and is found instead also at the plasma membrane.	Lysine	24-30	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	92-97
10816100-3	2000	While haem b is surrounded mainly by acidic amino acids, cytochrome c displays positive charged lysine groups around the haem site.	Lysine	96-102	cytochrome c, somatic	Homo sapiens	57-69
10709930-6	2000	Lysine uptake occurred by a transport mechanism with a Km of approximately 1.4 mM and a Vmax of 7.9 mmol x kg cell water(-1) x 30 min(-1).	Lysine	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	130-136
10644563-7	2000	The VIP(1)-R-selective ligand, [Lys(15),Arg(16),Leu(27)]VIP-(1-7)-GRF-(8-27), gave a monophasic pattern.	Lysine	32-35	vasoactive intestinal peptide	Rattus norvegicus	4-7
10739383-3	2000	This system, in the presence of 100 microM L-tyrosine, caused in the thrombin molecule loss of tryptophan and lysine residues and formation of dityrosine, chloramine and carbonyl groups.	Lysine	110-116	coagulation factor II, thrombin	Homo sapiens	69-77
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Lysine	158-164	apolipoprotein E	Homo sapiens	14-30
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Lysine	158-164	apolipoprotein E	Homo sapiens	32-36
10636847-6	2000	In addition, we show that GH internalization is independent of the presence of lysine residues in the cytosolic domain of the receptor, whereas its internalization can still be inhibited by proteasomal inhibitors.	Lysine	79-85	growth hormone 1	Homo sapiens	26-28
10633045-6	2000	For the p38-bound inhibitor, the anilino group was angled out of plane and was positioned between Lys-53 and Thr-106 in a manner similar to that observed for the aryl substituent of the pyridinylimidazole class of inhibitor.	Lysine	98-101	mitogen-activated protein kinase 14	Homo sapiens	8-11
10735543-1	2000	BACKGROUND: Previous in vitro experiments have indicated that if the ninth codon of the hepatitis C virus (HCV) core gene is mutated from arginine to lysine, a short 16-kDa (P16) instead of a 21-kDa (P21) core protein will be produced.	Lysine	150-156	cyclin dependent kinase inhibitor 2A	Homo sapiens	174-177
10664506-2	2000	S130K is a mutation of fibroblast growth factor-1 (FGF-1), with lysine replacing serine in the heparin-binding site.	Lysine	64-70	fibroblast growth factor 1	Homo sapiens	23-49
10664506-2	2000	S130K is a mutation of fibroblast growth factor-1 (FGF-1), with lysine replacing serine in the heparin-binding site.	Lysine	64-70	fibroblast growth factor 1	Homo sapiens	51-56
10639097-2	2000	Uniquely, 5-HT3 receptor subunits (5-HT3A and 5-HT3B) possess a positively charged lysine residue within the putative channel lining M2 domain (4" position).	Lysine	83-89	5-hydroxytryptamine receptor 3A	Homo sapiens	35-41
10623524-8	2000	A tight cluster of three lysine residues and one arginine residue atop beta-strands A and B, and identical among TIMP sequences, form the heart of a highly conserved electropositive patch that may interact with anionic components of the extracellular matrix.	Lysine	25-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	113-117
10644563-7	2000	The VIP(1)-R-selective ligand, [Lys(15),Arg(16),Leu(27)]VIP-(1-7)-GRF-(8-27), gave a monophasic pattern.	Lysine	32-35	vasoactive intestinal peptide	Rattus norvegicus	56-59
10644563-10	2000	At low concentrations (10 nM) of Ro-25-1553 and [Lys(15),Arg(16), Leu(27)]VIP-(1-7)-GRF(8-27), which only occupy VIP receptors, a 4-fold and a 56-fold increase in cAMP occurred, respectively.	Lysine	49-52	vasoactive intestinal peptide	Rattus norvegicus	74-77
10837052-12	2000	Notably, tTG can also cross-link glutamine residues of peptides to lysine residues in other proteins including tTG itself.	Lysine	67-73	transglutaminase 2	Homo sapiens	9-12
10837052-12	2000	Notably, tTG can also cross-link glutamine residues of peptides to lysine residues in other proteins including tTG itself.	Lysine	67-73	transglutaminase 2	Homo sapiens	111-114
10601259-3	1999	The alpha-carbon of the conserved lysine present near the C-terminal end of the transmembrane helix (Lys(1125) in alpha2, Lys(1022) in alpha5, Lys(752) in beta1, and Lys(724) in beta2) is buried in the plasma membrane, and the charged amino group most likely reaches into the polar head-group region of the lipid bilayer.	Lysine	34-40	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	155-160
10594033-0	2000	The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation.	Lysine	52-58	male-specific lethal 1	Drosophila melanogaster	15-18
10594033-4	2000	We have partially purified a complex containing MSL1, -2, and -3, MOF, MLE, and roX2 RNA and demonstrated that it exclusively acetylates H4 at lysine 16 on nucleosomal substrates.	Lysine	143-149	male-specific lethal 1	Drosophila melanogaster	48-64
10651742-0	2000	The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300-->Lys and Glu-309-->Lys substitutions.	Lysine	100-103	coagulation factor II, thrombin	Homo sapiens	4-15
10651742-0	2000	The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300-->Lys and Glu-309-->Lys substitutions.	Lysine	100-103	coagulation factor II, thrombin	Homo sapiens	49-60
10617692-0	2000	High-affinity binding of peptide agonists to the human B1 bradykinin receptor depends on interaction between the peptide N-terminal L-lysine and the fourth extracellular domain of the receptor.	Lysine	132-140	bradykinin receptor B1	Homo sapiens	55-77
10617692-2	2000	To reach this aim, we exploited the fact that high-affinity binding of kinin peptides to the human B1 receptor subtype requires a peptide N-terminal L-Lys, whereas high-affinity binding to the B2 receptor subtype does not require this residue.	Lysine	149-154	bradykinin receptor B1	Homo sapiens	99-110
10714610-7	2000	The cationic peptides, protamine and poly-L-lysine (each 300 microM), produced over 85% inhibition of 125I-bFGF binding to brain capillaries.	Lysine	37-50	fibroblast growth factor 2	Bos taurus	107-111
10714610-8	2000	Furthermore, glycosaminoglycans with a sulfate residue, chondroitin sulfate B and C (each 10 microg/mL) also inhibited the binding of 125I-bFGF The in vivo transcytosis of 125I-bFGF from the luminal side to the brain was also inhibited by the presence of heparin (10 microg/mL) and poly-L-lysine (300 microM), whereas neither hyaruronic acid (10 microg/mL) nor insulin (10 microM) had any effect.	Lysine	282-295	fibroblast growth factor 2	Bos taurus	139-143
10630376-1	1999	The biosynthesis of hypusine [Nepsilon-(4-amino-2-hydroxybutyl)-lysine] occurs in the eIF-5A precursor protein through two step posttranslational modification involving deoxyhypusine synthase which catalyzes transfer of the butylamine moiety of spermidine to the epsilon-amino group of a designated lysine residue and subsequent hydroxylation of this intermediate.	Lysine	64-70	deoxyhypusine synthase	Saccharomyces cerevisiae S288C	169-191
10601259-3	1999	The alpha-carbon of the conserved lysine present near the C-terminal end of the transmembrane helix (Lys(1125) in alpha2, Lys(1022) in alpha5, Lys(752) in beta1, and Lys(724) in beta2) is buried in the plasma membrane, and the charged amino group most likely reaches into the polar head-group region of the lipid bilayer.	Lysine	101-104	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	155-160
10600518-1	1999	Recent studies have implicated acetylation of several nuclear proteins such as histones and p53 on their epsilon-portion of lysine residues in eukaryotic transcription.	Lysine	124-130	tumor protein p53	Homo sapiens	92-95
10637513-6	1999	In contrast, integrin-linked kinase mutated in a lysine residue critical for function in protein kinases is inactive in these experiments, and furthermore, acts dominantly to block serine-473 phosphorylation induced by ErbB4.	Lysine	49-55	integrin linked kinase	Homo sapiens	13-35
10637513-8	1999	Mutation of this serine to aspartate or glutamate, but not alanine, in combination with the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of serine-473 of protein kinase B.	Lysine	105-111	integrin linked kinase	Homo sapiens	130-152
10585493-1	1999	We have previously shown that human cullin-2 (Cul-2) is covalently modified at Lys-689 by NEDD8 (Wada, H., Yeh, E. T. H., and Kamitani, T. (1999) Biochem.	Lysine	79-82	cullin 2	Homo sapiens	36-44
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Lysine	31-37	cyclin T1	Homo sapiens	154-163
10585493-1	1999	We have previously shown that human cullin-2 (Cul-2) is covalently modified at Lys-689 by NEDD8 (Wada, H., Yeh, E. T. H., and Kamitani, T. (1999) Biochem.	Lysine	79-82	cullin 2	Homo sapiens	46-51
10570056-8	1999	The antagonists [AcHis(1),D-Phe(2),Lys(15),Arg(16), Leu(27)]VIP(3-7)/GRF(8-27) and VIP(5-27) had comparable affinities for the wild-type receptors and for the two latter chimeras, supporting the hypothesis that these chimeras were properly folded but unable to reach the high-agonist-affinity, active receptor conformation in response to VIP binding.	Lysine	35-38	vasoactive intestinal peptide	Homo sapiens	60-63
10567233-2	1999	We prepared recombinant human H-FABP proteins with mutations in the hydrophobic patch (Phe(4), Trp(8) and Phe(64)), portal region (Phe(16)), hinge region (Leu(66), Gly(67)), second portal region (Glu(72)) and at the protein surface (Lys(21)) respectively.	Lysine	233-236	fatty acid binding protein 3	Homo sapiens	30-36
10583392-7	1999	In the carboxylate state, the structure is characterized by a salt-bridge between Arg(-1) and Asp8, which we identified previously in the [Lys(-2)-Arg(-1)]-endothelin-1 peptide (KR-ET-1).	Lysine	139-142	endothelin 1	Homo sapiens	156-168
10559333-4	1999	In addition, we showed that Rep1 and Rep2 proteins hydrolyze ATP, and by changing the key lysine residue in the proteins" nucleoside triphosphate binding sites, demonstrated that this ATPase activity is essential for multiplication of virus DNA in vivo.	Lysine	90-96	CHM like Rab escort protein	Homo sapiens	37-41
10551826-4	1999	To characterize further the function of these two domains, we demonstrate in this report that the previously described major nuclear localization signal works together with Lys(305)-Arg(306) to form a bipartite and functional nuclear localization sequence (NLS) for p53 nuclear import.	Lysine	173-176	tumor protein p53	Homo sapiens	266-269
10625451-4	1999	While His(4) or Gln(9) substitutions had little effect on IGFBP affinity, changing the negative charge of Glu(9) to a positive Lys(9) selectively decreased the affinities of IGFBP-2 and -6 by 140- and 30-fold, respectively.	Lysine	127-130	insulin-like growth factor binding protein 2	Rattus norvegicus	174-188
10563822-5	1999	For the Tyr63Leu mutant, a new low-spin signal resembling that of alkaline cytochrome c (a His-heme-Lys species) is resolved, suggesting that the E10 lysine now coordinates to the heme.	Lysine	100-103	cytochrome c, somatic	Homo sapiens	75-87
10563822-5	1999	For the Tyr63Leu mutant, a new low-spin signal resembling that of alkaline cytochrome c (a His-heme-Lys species) is resolved, suggesting that the E10 lysine now coordinates to the heme.	Lysine	150-156	cytochrome c, somatic	Homo sapiens	75-87
10562558-3	1999	A lysine residue at amino acid position 386 of p53 is required for this previously undescribed modification, strongly suggesting that this lysine residue serves as the major attachment site for SUMO-1.	Lysine	2-8	tumor protein p53	Homo sapiens	47-50
10562558-3	1999	A lysine residue at amino acid position 386 of p53 is required for this previously undescribed modification, strongly suggesting that this lysine residue serves as the major attachment site for SUMO-1.	Lysine	139-145	tumor protein p53	Homo sapiens	47-50
10558899-2	1999	The rat ATX1 homologue protein (Rah1p), which shows 35%, 38%, and 89% identities with Atx1p, CUC-1, and HAH1, respectively, conserves both the MTCXXC copper-binding site in the N terminus and the KTGK lysine-rich region in the C terminus.	Lysine	201-207	ribonuclease A family member 10	Rattus norvegicus	32-37
10542213-5	1999	Deamidase and transglutaminase activities were blocked in the mutant proteins Cys(1292) --&gt; Ala, His(1307) --&gt; Ala, and Lys(1310) --&gt; Ala of DeltaDNT.	Lysine	126-129	cathepsin A	Homo sapiens	0-9
10576765-2	1999	There are two known polymorphisms in exon 11 of the DBP gene that result in amino acid variants: at codons 416 GAT--&gt;GAG (Asp--&gt;Glu) and 420 ACG--&gt;AAG (Thr--&gt;Lys).	Lysine	170-173	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
10573382-6	1999	We observed a strong negative association between HLA-DRB1 alleles that encode lysine at position 71 in their beta-chain and susceptibility to ulcerative colitis.	Lysine	79-85	major histocompatibility complex, class II, DR beta 1	Homo sapiens	50-58
10619020-4	1999	Here, we provide a molecular explanation of this phenomenon and report that MyoD is directly acetylated by PCAF at evolutionarily conserved lysines.	Lysine	140-147	myogenic differentiation 1	Homo sapiens	76-80
10576165-7	1999	It was found that almost all of the lysines present in the acidic PRPs and statherin, and some of the lysines present in histatins, could participate in the crosslink reaction.	Lysine	36-43	statherin	Homo sapiens	75-84
10537045-3	1999	Further, the Gln and Lys residues in tau that are modified by tTG in vitro are located primarily within or adjacent to the microtubule-binding domains.	Lysine	21-24	transglutaminase 2	Homo sapiens	62-65
10517526-0	1999	Effect of lysine modification on the conformation and indomethacin binding properties of human serum albumin.	Lysine	10-16	albumin	Homo sapiens	95-108
10517526-1	1999	In order to study the involvement of lysine residues of human serum albumin (HSA) in the binding of indomethacin, HSA was treated with different molar excess of acetic anhydride, succinic anhydride and O-methylisourea which resulted in differently modified preparations: 30%, 62% and 87% acetylated, 20%, 34%, 64% and 78% succinylated and 21%, 43% and 86% guanidinated HSAs.	Lysine	37-43	albumin	Homo sapiens	62-75
10619020-6	1999	Importantly, conservative substitutions of acetylated lysines with nonacetylatable arginines impair the ability of MyoD to stimulate transcription and to induce muscle conversion indicating that acetylation of MyoD is functionally critical.	Lysine	54-61	myogenic differentiation 1	Homo sapiens	115-119
10619020-6	1999	Importantly, conservative substitutions of acetylated lysines with nonacetylatable arginines impair the ability of MyoD to stimulate transcription and to induce muscle conversion indicating that acetylation of MyoD is functionally critical.	Lysine	54-61	myogenic differentiation 1	Homo sapiens	210-214
10514289-6	1999	Substitution of the D-arginine residue by a L-lysine residue led to a 10-fold more potent bradykinin B(2) ligand [compound 22 (JMV1465) (K(i) 0.07 nM)], retaining full agonist activity on human umbilical vein.	Lysine	44-52	kininogen 1	Homo sapiens	90-100
10571985-4	1999	Conversion of this same lysine residue to glutamic acid (K142E) produced an enzyme that also displayed severely diminished catalytic activity, but one that now maintained FAAH"s ability to react with amides and esters at competitive rates.	Lysine	24-30	fatty acid amide hydrolase	Homo sapiens	171-175
10571985-5	1999	The significant catalytic defects exhibited by both the K142A and K142E mutants, in conjunction with their altered pH-rate profiles, support a role for lysine 142 as a general base involved in the activation of FAAH"s serine nucleophile.	Lysine	152-158	fatty acid amide hydrolase	Homo sapiens	211-215
10608719-3	1999	It results in the generation of aldehydes, which substitute lysine residues in the apolipoprotein B-100 moiety and thus in the generation of oxidized LDL.	Lysine	60-66	apolipoprotein B	Homo sapiens	83-103
10527866-3	1999	Because post-translational modifications that enhance their metal binding capacity should also increase their susceptibility to MCO, we have investigated the effect of lysine carboxymethylation on the oxidation of bovine serum albumin (BSA) by the Fe(3+)/ascorbate system.	Lysine	168-174	albumin	Homo sapiens	221-234
10497248-13	1999	However, residue Lys(5), but not Lys(6), turned out to be critical for the topology of 11beta-HSD1.	Lysine	17-20	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	87-98
10493908-8	1999	In contrast, the peptides with a position 2 (P2) lysine mutation, IGF-I(66-75)Lys(70) and IGF-II(63-72)Lys(67), were cleaved more efficiently by PC1 and furin compared with rPC4A.	Lysine	49-55	insulin like growth factor 1	Homo sapiens	66-71
10493908-8	1999	In contrast, the peptides with a position 2 (P2) lysine mutation, IGF-I(66-75)Lys(70) and IGF-II(63-72)Lys(67), were cleaved more efficiently by PC1 and furin compared with rPC4A.	Lysine	78-81	insulin like growth factor 1	Homo sapiens	66-71
10525358-2	1999	The primary structure of the peptide (Lys-Pro-Lys-Pro-His-Gln-Phe-Phe-Gly-Leu-Met.NH(2)) is the same in both species and contains 2 amino acid substitutions (Arg(1) --&gt; Lys and Gln(5) --&gt; His) compared with human substance P and 1 substitution (Arg(3) --&gt; Lys) compared with substance P from the trout (Teleostei).	Lysine	38-41	tachykinin precursor 1	Homo sapiens	219-236
10525358-2	1999	The primary structure of the peptide (Lys-Pro-Lys-Pro-His-Gln-Phe-Phe-Gly-Leu-Met.NH(2)) is the same in both species and contains 2 amino acid substitutions (Arg(1) --&gt; Lys and Gln(5) --&gt; His) compared with human substance P and 1 substitution (Arg(3) --&gt; Lys) compared with substance P from the trout (Teleostei).	Lysine	38-41	tachykinin precursor 1	Homo sapiens	219-230
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Lysine	87-90	tachykinin precursor 1	Homo sapiens	243-261
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Lysine	87-90	tachykinin precursor 1	Homo sapiens	392-410
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Lysine	102-105	tachykinin precursor 1	Homo sapiens	243-261
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Lysine	102-105	tachykinin precursor 1	Homo sapiens	392-410
10505700-2	1999	KTS (lysine-threonine-serine) splice site mutations in WT1 intron 9 have been described in patients with Frasier syndrome, another rare syndrome defined by focal and segmental glomerulosclerosis (FSGS), XY pseudohermaphroditism, and frequent occurrence of gonadoblastoma.	Lysine	5-11	WT1 transcription factor	Homo sapiens	55-58
10486321-6	1999	This mutation changes a methionine to a lysine residue in the middle of the first N-terminal membrane-spanning region of COX II.	Lysine	40-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-127
10491201-7	1999	Replacement of the His6 residue of alpha-MSH-ND by Gln, Asn, Arg or Lys decreased not only the receptor binding, but also the cAMP-generating activity in both the MC3R and the MC4R.	Lysine	68-71	melanocortin receptor 3	Cricetulus griseus	163-167
10521041-7	1999	Milk protein percentage tended to be higher when cows were fed diets supplemented with ruminally protected lysine and methionine; however, production of milk, milk fat, and milk lactose were not affected by any treatment.	Lysine	107-113	Weaning weight-maternal milk	Bos taurus	0-4
10501225-1	1999	In alpha1, beta2, and gamma2 subunits of the gamma-aminobutyric acid A (GABA(A)) receptor, a conserved lysine residue occupies the position in the middle of the predicted extracellular loop between the transmembrane M2 and M3 regions.	Lysine	103-109	tryptophanyl-tRNA synthetase 1	Homo sapiens	22-28
10582243-9	1999	The C-terminal glycine residue of a novel modifier protein Apg12p, a 186-amino-acid protein, is conjugated to a lysine residue of Apg5p, a 294-amino-acid protein, via an isopeptide bond.	Lysine	112-118	Atg5p	Saccharomyces cerevisiae S288C	130-135
10488098-3	1999	Mutant D, with changes at Arg(184), Lys(185), Arg(189), Arg(192), Arg(193), demonstrated a approximately 130-fold increased rate of thrombin inactivation that was unaffected by the presence of glycosaminoglycans.	Lysine	36-39	coagulation factor II, thrombin	Homo sapiens	132-140
10556557-5	1999	Based on the efficiency of resonance fluorescence energy transfer in the donor-acceptor pair, FITC-heme, we calculated the distance between Lys(338), selectively labeled with the dye, and the heme of P450scc.	Lysine	140-143	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	200-207
10480907-0	1999	Crucial role of Lys(423) in the electron transfer of neuronal nitric-oxide synthase.	Lysine	16-19	nitric oxide synthase 2	Homo sapiens	62-83
10480873-3	1999	To measure this moesin-specific activity, a nonradioactive enzyme-linked immunosorbent assay method was developed with the synthetic peptide Cys-Lys(555)-Tyr-Lys-Thr(P)-Leu-Arg(560) coupled to bovine serum albumin as the substrate and moesin phosphorylation state-specific polyclonal antibodies for the detection and quantitation of dephosphorylation.	Lysine	145-148	moesin	Homo sapiens	16-22
10480873-3	1999	To measure this moesin-specific activity, a nonradioactive enzyme-linked immunosorbent assay method was developed with the synthetic peptide Cys-Lys(555)-Tyr-Lys-Thr(P)-Leu-Arg(560) coupled to bovine serum albumin as the substrate and moesin phosphorylation state-specific polyclonal antibodies for the detection and quantitation of dephosphorylation.	Lysine	158-161	moesin	Homo sapiens	16-22
10517223-1	1999	Tissue transglutaminase (tTG) is a calcium-activated enzyme which can covalently crosslink the epsilon-amino group of a peptide-bound lysine into the gamma-carboxamide group of a peptide-bound glutamine, forming a epsilon-(-gamma-glutamyl)lysine isopeptide bond.	Lysine	134-140	transglutaminase 2	Homo sapiens	0-23
10517223-1	1999	Tissue transglutaminase (tTG) is a calcium-activated enzyme which can covalently crosslink the epsilon-amino group of a peptide-bound lysine into the gamma-carboxamide group of a peptide-bound glutamine, forming a epsilon-(-gamma-glutamyl)lysine isopeptide bond.	Lysine	239-245	transglutaminase 2	Homo sapiens	0-23
10517223-1	1999	Tissue transglutaminase (tTG) is a calcium-activated enzyme which can covalently crosslink the epsilon-amino group of a peptide-bound lysine into the gamma-carboxamide group of a peptide-bound glutamine, forming a epsilon-(-gamma-glutamyl)lysine isopeptide bond.	Lysine	239-245	transglutaminase 2	Homo sapiens	25-28
10517223-1	1999	Tissue transglutaminase (tTG) is a calcium-activated enzyme which can covalently crosslink the epsilon-amino group of a peptide-bound lysine into the gamma-carboxamide group of a peptide-bound glutamine, forming a epsilon-(-gamma-glutamyl)lysine isopeptide bond.	Lysine	134-140	transglutaminase 2	Homo sapiens	25-28
10464296-9	1999	These findings, together with those on the crystal structure of estrogen sulfotransferase and heparan sulfate N-deacetylase/sulfotransferase, suggest that Lys(128) may be close to the 3-hydroxyl group of beta-glucuronic acid in a HNK-1 acceptor.	Lysine	155-158	beta-1,3-glucuronyltransferase 1	Homo sapiens	230-235
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Lysine	131-134	coagulation factor II, thrombin	Homo sapiens	106-114
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Lysine	57-60	mitogen-activated protein kinase kinase 4	Homo sapiens	51-55
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Lysine	158-161	coagulation factor II, thrombin	Homo sapiens	106-114
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Lysine	158-161	coagulation factor II, thrombin	Homo sapiens	106-114
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Lysine	158-161	coagulation factor II, thrombin	Homo sapiens	106-114
10465285-17	1999	Subsequent N-terminal sequencing showed that the thrombin cleavage occurred between amino acid residues 53 (Lys) and 54 (Ala), resulting in the formation of a C-terminal, not an N-terminal, 16K fragment.	Lysine	108-111	coagulation factor II, thrombin	Homo sapiens	49-57
10433522-4	1999	In contrast, Ca+-signalling and spreading of the cells adhering to laminin or collagen type IV combined with poly-L-lysine was completely blocked by anti-beta1 mAb.	Lysine	109-122	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	154-159
10435998-11	1999	The net effect of increasing open state stability, either by PIP(2) or mutagenesis, is an apparent "uncoupling" of the Kir6.2 subunit from the regulatory input of SUR1, an action that can be partially reversed by screening negative charges on the membrane with poly-L-lysine.	Lysine	261-274	prolactin induced protein	Homo sapiens	61-64
10479347-0	1999	Preparation of a microcrystalline suspension formulation of Lys(B28)Pro(B29)-human insulin with ultralente properties.	Lysine	60-63	insulin	Homo sapiens	83-90
10479347-1	1999	The monomeric analogue, Lys(B28)Pro(B29)-human insulin (LysPro), has been crystallized using similar conditions employed to prepare extended-acting insulin ultralente formulations.	Lysine	24-27	insulin	Homo sapiens	47-54
10479347-1	1999	The monomeric analogue, Lys(B28)Pro(B29)-human insulin (LysPro), has been crystallized using similar conditions employed to prepare extended-acting insulin ultralente formulations.	Lysine	24-27	insulin	Homo sapiens	148-155
10471444-17	1999	Reduced relative electrophoretic mobility and increased trinitrobenzenesulfonic acid reactivity of LDL from treated rats (P&lt;0.01) also indicated that fewer lysine residues of apolipoprotein B were oxidatively modified in the presence of 1,4-DHP CCBs.	Lysine	159-165	apolipoprotein B	Rattus norvegicus	178-194
10452964-12	1999	The major glycated site of apoE was found to be Lys-75.	Lysine	48-51	apolipoprotein E	Homo sapiens	27-31
10400740-0	1999	A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.	Lysine	2-8	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	108-111
10400740-3	1999	p12(I) is ubiquitylated, and mutations of its unique carboxy-terminus lysine residue to an arginine greatly enhance its stability.	Lysine	70-76	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	0-3
10400740-4	1999	Interestingly, analysis of 53 independent HTLV-1 strains revealed that the natural p12(I) alleles found in ex vivo samples of tropical spastic paraparesis-HTLV-1-associated myelopathy patients contain a Lys at position 88 in some cases, whereas arginine is consistently found at position 88 in HTLV-1 strains from all adult T-cell leukemia-lymphoma (ATLL) cases and healthy carriers studied.	Lysine	203-206	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	83-86
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Lysine	57-60	mitogen-activated protein kinase 8	Homo sapiens	94-97
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Lysine	57-60	mitogen-activated protein kinase 8	Homo sapiens	125-128
10413500-11	1999	Molecular modeling showed that the heparin-binding domain of FGF-1 includes cysteine-131 and that cysteine-131, upon oxidation to cysteic acid during the iodination procedures, would interact with lysine-126 and lysine-132.	Lysine	197-203	fibroblast growth factor 1	Homo sapiens	61-66
10414533-2	1999	This partial cDNA shows 90% identity with mammalian GAD 65 and presents the Asn-Pro-His-Lys (NPHK) sequence corresponding to the pyridoxal-binding region of porcine DOPA decarboxylase or mammalian GAD.	Lysine	88-91	dopa decarboxylase	Homo sapiens	165-183
10437795-2	1999	Signal induced phosphorylation of IkappaBalpha on serine 32 and 36 targets the protein for ubiquitination on lysine 21 and 22.	Lysine	109-115	NFKB inhibitor alpha	Homo sapiens	34-46
10413500-11	1999	Molecular modeling showed that the heparin-binding domain of FGF-1 includes cysteine-131 and that cysteine-131, upon oxidation to cysteic acid during the iodination procedures, would interact with lysine-126 and lysine-132.	Lysine	212-218	fibroblast growth factor 1	Homo sapiens	61-66
10499291-1	1999	The acetylation of the hemeundecapeptide prepared by proteolysis of cytochrome c yields a species di(N-acetyl)-microperoxidase-11, NAcMP11, that is monomeric in aqueous solution at least for concentrations below 20 microM, in contrast to MP11 itself, which aggregates because of intermolecular coordination of Fe(III) by the N-terminal amino group or the amino group of the side chain of Lys-13.	Lysine	388-391	cytochrome c, somatic	Homo sapiens	68-80
10416603-2	1999	In this study, we combined this Adv (Adv-E1AdB) with a fiber mutation, F/K20, which has a stretch of 20 lysine residues added at the COOH-terminus of the fiber and shows high transduction efficiency to gliomas.	Lysine	104-110	keratin 20	Homo sapiens	73-76
10499291-1	1999	The acetylation of the hemeundecapeptide prepared by proteolysis of cytochrome c yields a species di(N-acetyl)-microperoxidase-11, NAcMP11, that is monomeric in aqueous solution at least for concentrations below 20 microM, in contrast to MP11 itself, which aggregates because of intermolecular coordination of Fe(III) by the N-terminal amino group or the amino group of the side chain of Lys-13.	Lysine	388-391	non-compact myelin associated protein	Homo sapiens	134-138
10407226-5	1999	DESIGN AND METHODS: [Leu(27)]-cyclo(Glu(22)-Lys(26))-hPTH-(1--31)NH(2) was delivered by Alzet minipumps to ovariectomized rats for 6 weeks after which histomorphometric indices (cancellous bone volume, trabecular thickness, mean trabecular number) of bone formation were measured in distal femurs.	Lysine	44-47	parathyroid hormone	Homo sapiens	53-57
10411468-4	1999	Conjugation of lysozyme with estrone glucuronide by the mixed anhydride procedure gave one major derivative exclusively acylated at lysine residue 33 whereas conjugation by the active ester method gave six derivatives which were acylated at one or more of lysine residues 33, 97, and 116.	Lysine	132-138	lysozyme	Homo sapiens	15-23
10411468-4	1999	Conjugation of lysozyme with estrone glucuronide by the mixed anhydride procedure gave one major derivative exclusively acylated at lysine residue 33 whereas conjugation by the active ester method gave six derivatives which were acylated at one or more of lysine residues 33, 97, and 116.	Lysine	256-262	lysozyme	Homo sapiens	15-23
10411468-6	1999	The correlation of the conjugate structures with the protein environments of the amino groups in the crystal structure of lysozyme suggested that the sites of acylation were determined not only by the chemical nature of the acylating reagent but also by the surface accessibility and nucleophilicity of the individual lysine residues.	Lysine	318-324	lysozyme	Homo sapiens	122-130
10407226-6	1999	RESULTS: Infusing low doses (0.05 and 0.1 nmole/100g body weight/day) of the hPTH analog, [Leu(27)]-cyclo(Glu(22)-Lys(26))-hPTH-(1--31)NH(2), for 6 weeks does not prevent the ovariectomy-induced loss of rat femoral cancellous bone volume, trabecular thickness or trabecular number.	Lysine	114-117	parathyroid hormone	Homo sapiens	77-81
10407226-6	1999	RESULTS: Infusing low doses (0.05 and 0.1 nmole/100g body weight/day) of the hPTH analog, [Leu(27)]-cyclo(Glu(22)-Lys(26))-hPTH-(1--31)NH(2), for 6 weeks does not prevent the ovariectomy-induced loss of rat femoral cancellous bone volume, trabecular thickness or trabecular number.	Lysine	114-117	parathyroid hormone	Homo sapiens	123-127
10445847-1	1999	The downregulation of tyrosine kinase receptors attenuates signalling and is thought to be dependent upon intrinsic receptor kinase activity, largely because down-regulation is inhibited by a kinase-inactivating mutation of an invariant lysine residue of the receptors for EGF, insulin, M-CSF and PDGF.	Lysine	237-243	insulin	Homo sapiens	278-285
10428170-11	1999	A five-nucleotide "AGGAA" deletion at codons 608 and 609 of the androgen receptor gene resulted in a missing arginine and lysine as well as a frameshift that introduced a stop codon 12 amino acid downstream from the mutation.	Lysine	122-128	androgen receptor	Homo sapiens	64-81
10387054-1	1999	Lysyl-tRNA synthetase (LysRS), a class II enzyme whose major function is to provide Lys-tRNALys for protein synthesis, also catalyzes aminoacylation of tRNALys with arginine, threonine, methionine, leucine, alanine, serine, and cysteine.	Lysine	0-3	lysyl-tRNA synthetase 1	Homo sapiens	23-28
10358030-4	1999	Substitution of Asp10 in [Nle4]Lys-gamma2-MSH for Gly10 from [Nle4]alpha-MSH, increased both activity and affinity for the MC4R while the MC3R remained unaffected.	Lysine	31-34	proopiomelanocortin	Homo sapiens	42-45
10364572-6	1999	Experimental results were compared with the predictions of a mechanical model in which the elastic titin segment behaves as two wormlike chains, the tandem immunoglobulin (Ig) segments and the PEVK segment (rich in proline [P], glutamate [E], valine [V], and lysine [K] residues), connected in series.	Lysine	259-265	titin	Rattus norvegicus	99-104
10390608-9	1999	Gene delivery to K562 haematopoietic leukaemic cells was achieved by using a transferrin-polycation (poly-L-lysine or protamine) conjugate.	Lysine	101-114	transferrin	Homo sapiens	77-88
10333484-0	1999	Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation.	Lysine	122-125	calmodulin 1	Homo sapiens	94-104
10380914-5	1999	We observed that wortmannin, LY 294002, and PD 098059 reduce basophil ERK-1,2 activation, thus implying that, with regard to arachidonic acid metabolism, MEK kinases are a downstream target for PI-3-kinase.	Lysine	29-31	mitogen-activated protein kinase 3	Homo sapiens	70-77
10336644-7	1999	We conclude that somatic forms of ACE should be considered as alternatives to CPs for the removal of basic residues from some Arg/Lys-extended peptides.	Lysine	130-133	angiotensin I converting enzyme	Homo sapiens	34-37
10380914-5	1999	We observed that wortmannin, LY 294002, and PD 098059 reduce basophil ERK-1,2 activation, thus implying that, with regard to arachidonic acid metabolism, MEK kinases are a downstream target for PI-3-kinase.	Lysine	29-31	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
10350607-6	1999	These results showed that Ser-158, Tyr-171, and Lys-175 contributed to the catalytic activity of SPR, and both Tyr-171 and Ser-158 are simultaneously necessary on proton transfer to the carbonyl functional groups of substrate.	Lysine	48-51	sepiapterin reductase	Mus musculus	97-100
10350461-1	1999	Trinitrophenylation of the reactive lysine (Lys84) in skeletal myosin subfragment 1 (S1) introduces a chiral probe (TNP) into an interface of the catalytic and lever arm domains of S1 [Muhlrad (1977) Biochim.	Lysine	36-42	proteasome 26S subunit, non-ATPase 1	Homo sapiens	85-87
10224068-7	1999	Formation of isolevuglandin-lysine adducts on apolipoprotein B was readily detected during oxidation of low density lipoprotein following enzymatic digestion of the protein to single amino acids.	Lysine	28-34	apolipoprotein B	Homo sapiens	46-62
10350461-1	1999	Trinitrophenylation of the reactive lysine (Lys84) in skeletal myosin subfragment 1 (S1) introduces a chiral probe (TNP) into an interface of the catalytic and lever arm domains of S1 [Muhlrad (1977) Biochim.	Lysine	36-42	proteasome 26S subunit, non-ATPase 1	Homo sapiens	181-183
10332684-1	1999	OBJECTIVE: To quantitate the contribution of postprandial blood glucose, which improves with the short-acting insulin analog lispro [Lys(B28),Pro(B29)] in type 1 diabetes, to the overall 24-h blood glucose concentration and the long-term HbA1c concentration under conditions of different postabsorptive blood glucose.	Lysine	133-136	insulin	Homo sapiens	110-117
10101221-2	1999	The antiinflammatory activity of manoalide is due to inhibition of PLA2, through irreversible binding to several lysine residues.	Lysine	113-119	phospholipase A2 group IB	Homo sapiens	67-71
10101221-5	1999	It appears that the minimum structural requirement for exhibiting manoalide-like PLA2 inhibition would be the presence in the inhibitor of functional groups able to seize the amino groups of PLA2 lysine residues with formation of stable covalent bonds.	Lysine	196-202	phospholipase A2 group IB	Homo sapiens	81-85
10101221-5	1999	It appears that the minimum structural requirement for exhibiting manoalide-like PLA2 inhibition would be the presence in the inhibitor of functional groups able to seize the amino groups of PLA2 lysine residues with formation of stable covalent bonds.	Lysine	196-202	phospholipase A2 group IB	Homo sapiens	191-195
10340621-0	1999	Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: ion-dipole interactions with lysine 60G.	Lysine	102-108	coagulation factor II, thrombin	Homo sapiens	52-60
10340621-2	1999	The interaction of a number of piperidine P2 functionalities with lysine 60G of thrombin is explored with reference to the crystal structure of inhibitor enzyme complexes.	Lysine	66-72	coagulation factor II, thrombin	Homo sapiens	80-88
10331397-13	1999	In contrast, the insulin effects on phenylalanine, leucine, and lysine transport were similar at rest and after exercise.	Lysine	64-70	insulin	Homo sapiens	17-24
10207063-6	1999	Lys residues within the peptide were critical for both p53 activation and core domain binding.	Lysine	0-3	tumor protein p53	Homo sapiens	55-58
10194416-0	1999	NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains.	Lysine	109-115	amino acid permease GAP1	Saccharomyces cerevisiae S288C	61-66
10194416-7	1999	In proline-grown wild-type and npi2/doa4 cells overproducing ubiquitin, Gap1p appears to be mono-ubiquitinated at two lysine acceptor sites.	Lysine	118-124	amino acid permease GAP1	Saccharomyces cerevisiae S288C	72-77
10194416-8	1999	Addition of NH4+ triggers rapid poly-ubiquitination of Gap1p, the poly-ubiquitin chains being specifically formed by linkage through the lysine 63 residue of ubiquitin.	Lysine	137-143	amino acid permease GAP1	Saccharomyces cerevisiae S288C	55-60
10207073-3	1999	Here we report that CBP, but not p/CAF, acetylates GATA-1 at two highly conserved lysine-rich motifs present at the C-terminal tails of both zinc fingers.	Lysine	82-88	CREB binding protein	Homo sapiens	20-23
10207073-3	1999	Here we report that CBP, but not p/CAF, acetylates GATA-1 at two highly conserved lysine-rich motifs present at the C-terminal tails of both zinc fingers.	Lysine	82-88	GATA binding protein 1	Homo sapiens	51-57
10341419-5	1999	In Saccharomyces cerevisiae, Kex1p can cleave lysine and arginine residues from the C-terminus of peptides and proteins.	Lysine	46-52	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	29-34
10361278-5	1999	Mutation of the Ino80p lysine residue corresponding to the NTP binding site of Snf2p led to a non-functional protein.	Lysine	23-29	chromatin-remodeling ATPase INO80	Saccharomyces cerevisiae S288C	16-22
10341419-6	1999	We hypothesized that the KEX1 homologue in P. pastoris is responsible for the loss of the C-terminal lysine of endostatin.	Lysine	101-107	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	25-29
10341419-9	1999	Disruption of the KEX1 reading frame allowed expression of murine and human endostatin with the C-terminal lysine.	Lysine	107-113	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	18-22
10206965-3	1999	To investigate the importance of this position, Glu300 of rat CPE was converted into Gln, Lys, or Tyr, and the proteins expressed in Sf9 cells using the baculovirus system.	Lysine	90-93	carboxypeptidase E	Rattus norvegicus	62-65
10350073-0	1999	Mutation of Lys-75 affects calmodulin conformation.	Lysine	12-15	calmodulin 1	Homo sapiens	27-37
10092517-6	1999	Mapping of the NEDD8-conjugation site revealed that Lys-689 in human cullin-2 is conjugated by NEDD8.	Lysine	52-55	cullin 2	Homo sapiens	69-77
10191270-4	1999	In order to circumvent these problems we have synthesized an SP-C analogue, named SP-C(LKS), which differs from SP-C mainly by the exchange of most of the Val residues in positions 16-28 with Leu residues to promote an alpha-helical conformation, and by the introduction of Lys residues at positions 17, 22 and 27 in order to locate positive charges around the helical circumference and thereby avoid self polymerization.	Lysine	274-277	surfactant protein C	Homo sapiens	61-65
10191270-4	1999	In order to circumvent these problems we have synthesized an SP-C analogue, named SP-C(LKS), which differs from SP-C mainly by the exchange of most of the Val residues in positions 16-28 with Leu residues to promote an alpha-helical conformation, and by the introduction of Lys residues at positions 17, 22 and 27 in order to locate positive charges around the helical circumference and thereby avoid self polymerization.	Lysine	274-277	surfactant protein C	Homo sapiens	82-86
10191270-4	1999	In order to circumvent these problems we have synthesized an SP-C analogue, named SP-C(LKS), which differs from SP-C mainly by the exchange of most of the Val residues in positions 16-28 with Leu residues to promote an alpha-helical conformation, and by the introduction of Lys residues at positions 17, 22 and 27 in order to locate positive charges around the helical circumference and thereby avoid self polymerization.	Lysine	274-277	surfactant protein C	Homo sapiens	82-86
10198256-7	1999	This multiprotein complex exhibits a kinase activity with a requirement for lysine 821 in the BUB1 kinase motif, resulting in BUB1 autophosphorylation and phosphorylation of associated MAD1.	Lysine	76-82	mitotic arrest deficient 1 like 1	Homo sapiens	185-189
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	NEDD8 family protein RUB1	Saccharomyces cerevisiae S288C	263-267
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	273-276	cullin 2	Homo sapiens	50-58
10198233-2	1999	TNF-alpha was chemically conjugated with the terminal carboxyl-bearing PVP at one end of its main chain, which was radically polymerized via the formation of an amide bond between the lysine amino groups of TNF-alpha and carboxyl group of PVP.	Lysine	184-190	tumor necrosis factor	Homo sapiens	0-9
10198233-2	1999	TNF-alpha was chemically conjugated with the terminal carboxyl-bearing PVP at one end of its main chain, which was radically polymerized via the formation of an amide bond between the lysine amino groups of TNF-alpha and carboxyl group of PVP.	Lysine	184-190	tumor necrosis factor	Homo sapiens	207-216
10198233-4	1999	In contrast, PVP-TNF-alpha in which 40% of TNF-alpha lysine residues were coupled with PVP (MPVP-TNF-alpha) exhibited the highest anti-tumor activity among the conjugated derivatives examined.	Lysine	53-59	tumor necrosis factor	Homo sapiens	17-26
10198233-4	1999	In contrast, PVP-TNF-alpha in which 40% of TNF-alpha lysine residues were coupled with PVP (MPVP-TNF-alpha) exhibited the highest anti-tumor activity among the conjugated derivatives examined.	Lysine	53-59	tumor necrosis factor	Homo sapiens	43-52
10198233-4	1999	In contrast, PVP-TNF-alpha in which 40% of TNF-alpha lysine residues were coupled with PVP (MPVP-TNF-alpha) exhibited the highest anti-tumor activity among the conjugated derivatives examined.	Lysine	53-59	tumor necrosis factor	Homo sapiens	43-52
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	cullin 2	Homo sapiens	50-58
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	cullin CDC53	Saccharomyces cerevisiae S288C	171-176
10363648-9	1999	Analysis of the ubiquitination site has revealed that the N-terminal residue of MyoD is sufficient and essential to promote conjugation and subsequent degradation of the protein: conjugation to internal Lys residues is not necessary.	Lysine	203-206	myogenic differentiation 1	Homo sapiens	80-84
10191282-3	1999	In solution, PLA2-Lp[a] was a monomer, and when assessed by sedimentation velocity it behaved like untreated Lp[a], in that it remained compact in NaCl solutions but assumed the extended form in the presence of 6-amino hexanoic acid, which was shown previously to have an affinity for the apo[a] lysine binding site II (LBS II) comprising kringles IV5-8.	Lysine	296-302	phospholipase A2 group IB	Homo sapiens	13-17
10103047-0	1999	In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.	Lysine	86-92	Lys14p	Saccharomyces cerevisiae S288C	144-150
10103047-1	1999	Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional activator Lys14p in the presence of alpha-aminoadipate semialdehyde (alphaAASA), an intermediate of the pathway acting as a coinducer.	Lysine	39-45	Lys14p	Saccharomyces cerevisiae S288C	136-142
10103047-8	1999	The data are consistent with the conclusion that inhibition by lysine of Lys14p activation results from the control of alphaAASA production through the feedback inhibition of homocitrate synthase activity.	Lysine	63-69	Lys14p	Saccharomyces cerevisiae S288C	73-79
10082131-6	1999	Caspase 3-like activity but not caspase 1-like activity was detected in adherent cells on both collagen-coated and poly-L-lysine-coated plates but not in suspended cells.	Lysine	115-128	caspase 3	Homo sapiens	0-9
10363586-1	1999	The Fab fragment of monoclonal antibody B4G7 against human epidermal growth factor (EGF) receptor was conjugated with cationic poly-L-lysine and the resulting conjugate was further complexed with reporter genes or therapeutic genes.	Lysine	127-140	epidermal growth factor receptor	Homo sapiens	59-97
10072758-9	1999	CnB-binding peptides are negatively charged with clusters of hydrophobic residues rich in phenylalanine, whereas the CaM-binding peptides are positively charged and often contain an Arg/Lys-Trp motif.	Lysine	186-189	calmodulin 1	Homo sapiens	117-120
10321742-1	1999	It has been reported that Lysine-305 is needed for the nuclear import of the p53 protein (Liang et al., 1998).	Lysine	26-32	tumor protein p53	Homo sapiens	77-80
10321742-2	1999	In the present study, further mutagenesis analyses were carried out between Lys-305 and the major nuclear localization signal (NLS I) of p53.	Lysine	76-79	tumor protein p53	Homo sapiens	137-140
10085102-9	1999	The predicted amino acid sequence showed 78% identity to human tapasin with identical consensus sequences of signal peptide, N-linked glycosylation site, transmembrane domain and double lysine motif.	Lysine	186-192	TAP binding protein	Homo sapiens	63-70
10049496-0	1999	A basic residue, Lys 782, composes part of the ATP-binding site on the epidermal growth factor receptor tyrosine kinase.	Lysine	17-20	epidermal growth factor receptor	Homo sapiens	71-103
12953991-0	1999	P53 gene of chang-liver cells (Atcc-Ccl13) exposed to aflatoxin B1 (Afb): the effect of lysine on mutation at codon 249 of exon 7.	Lysine	88-94	tumor protein p53	Homo sapiens	0-3
12953991-1	1999	The effect of different regimes of lysine-pre treatment on mutation at the 3rd nucleotide base of codon 249 which is located at the 7th exon of p53 gene of Chang-liver cells (CCIL13) exposed to aflatoxin B1 (AFB1) has been investigated.	Lysine	35-41	tumor protein p53	Homo sapiens	144-147
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Lysine	28-31	epidermal growth factor receptor	Homo sapiens	246-278
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Lysine	174-177	epidermal growth factor receptor	Homo sapiens	246-278
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Lysine	70-73	apolipoprotein A1	Homo sapiens	23-30
10092100-4	1999	We have designed an original in vivo gene transfer using a mixture of liposomes and poly-L-Lysine that greatly enhanced the transfection yield, and induced a fast and long-lasting expression of IL-10 on mouse thyroid follicular cells (TFC).	Lysine	84-97	interleukin 10	Mus musculus	194-199
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Lysine	86-89	apolipoprotein A1	Homo sapiens	23-30
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Lysine	86-89	apolipoprotein A1	Homo sapiens	23-30
9931257-8	1999	This amide positioning is unique to the chymase-related proteinases, and only chymases from primates possess a Lys residue at position 40.	Lysine	111-114	chymase 1	Homo sapiens	40-47
10221692-4	1999	Genetic analysis revealed a single nucleotide substitution on exon 4 in the hormone-binding domain of the androgen receptor (AR) gene, resulting in a change of codon 681 GAG (glutamic acid) to AAG (lysine).	Lysine	198-204	androgen receptor	Homo sapiens	106-123
10221692-4	1999	Genetic analysis revealed a single nucleotide substitution on exon 4 in the hormone-binding domain of the androgen receptor (AR) gene, resulting in a change of codon 681 GAG (glutamic acid) to AAG (lysine).	Lysine	198-204	androgen receptor	Homo sapiens	125-127
10069801-1	1999	We reported previously that a conformation-specific antibody, Ab P2, to a 16-amino acid peptide (Glu-Gly-Tyr-Lys-Lys-Lys-Tyr-Gln-Gln-Val-Asp-Glu-Glu-Phe-Leu-Arg) of the cytoplasmic domain of the beta-type platelet-derived growth factor receptor also recognizes the epidermal growth factor (EGF) receptor.	Lysine	109-112	platelet derived growth factor receptor beta	Homo sapiens	195-244
10069801-1	1999	We reported previously that a conformation-specific antibody, Ab P2, to a 16-amino acid peptide (Glu-Gly-Tyr-Lys-Lys-Lys-Tyr-Gln-Gln-Val-Asp-Glu-Glu-Phe-Leu-Arg) of the cytoplasmic domain of the beta-type platelet-derived growth factor receptor also recognizes the epidermal growth factor (EGF) receptor.	Lysine	109-112	epidermal growth factor receptor	Homo sapiens	265-303
10051546-3	1999	A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function.	Lysine	2-8	cannabinoid receptor 1	Homo sapiens	110-113
10026228-8	1999	Unexpectedly, mutation of an Asp-Lys-Asp motif within domain A identified a putative cytoplasmic membrane-associated export signal that mediates Cdx-3 compartmentalization.	Lysine	33-36	caudal type homeobox 4	Mus musculus	145-150
10049942-5	1999	The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor-associated polypeptide (KARAP)/DAP12.	Lysine	23-29	natural cytotoxicity triggering receptor 2	Homo sapiens	96-101
10350084-0	1999	The Arabidopsis thaliana dhdps gene encoding dihydrodipicolinate synthase, key enzyme of lysine biosynthesis, is expressed in a cell-specific manner.	Lysine	89-95	dihydrodipicolinate synthase 1	Arabidopsis thaliana	45-73
10350084-2	1999	The enzyme that catalyses this step, dihydrodipicolinate synthase (DHDPS), is inhibited by the end-product lysine and is therefore thought to have a regulatory control on lysine synthesis.	Lysine	107-113	dihydrodipicolinate synthase 1	Arabidopsis thaliana	37-65
10350084-2	1999	The enzyme that catalyses this step, dihydrodipicolinate synthase (DHDPS), is inhibited by the end-product lysine and is therefore thought to have a regulatory control on lysine synthesis.	Lysine	171-177	dihydrodipicolinate synthase 1	Arabidopsis thaliana	37-65
10022840-4	1999	PU.1-Pip interaction is shown to be template directed and involves two distinct protein-protein interaction surfaces: (i) the ets and IRF DNA-binding domains; and (ii) the phosphorylated PEST region of PU.1 and a lysine-requiring putative alpha-helix in Pip.	Lysine	213-219	prolactin induced protein	Homo sapiens	5-8
10022840-4	1999	PU.1-Pip interaction is shown to be template directed and involves two distinct protein-protein interaction surfaces: (i) the ets and IRF DNA-binding domains; and (ii) the phosphorylated PEST region of PU.1 and a lysine-requiring putative alpha-helix in Pip.	Lysine	213-219	prolactin induced protein	Homo sapiens	254-257
9885292-6	1999	MEC-12 is the only identified C. elegans alpha-tubulin that contains a lysine at position 40, a known site of post-translational acetylation.	Lysine	71-77	Detyrosinated tubulin alpha-3 chain	Caenorhabditis elegans	0-6
9931011-4	1999	Mutation of the lysine residue in the "Walker A" motif of either the first nucleotide binding fold (CFTRK464A) or the second nucleotide binding fold (CFTRK1250A) inhibited the ATPase activity of the purified intact CFTR protein significantly, by greater than 50%.	Lysine	16-22	CF transmembrane conductance regulator	Homo sapiens	100-104
9925654-0	1999	Characterization of apolipoprotein E7 (Glu(244)--&gt;Lys, Glu(245)---&gt;Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.	Lysine	53-56	apolipoprotein E	Homo sapiens	20-36
9925654-0	1999	Characterization of apolipoprotein E7 (Glu(244)--&gt;Lys, Glu(245)---&gt;Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.	Lysine	73-76	apolipoprotein E	Homo sapiens	20-36
9925654-13	1999	Characterization of apolipoprotein E7 (Glu(244)--&gt;Lys, Glu(245)---&gt;Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.	Lysine	53-56	apolipoprotein E	Homo sapiens	20-36
9925654-13	1999	Characterization of apolipoprotein E7 (Glu(244)--&gt;Lys, Glu(245)---&gt;Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.	Lysine	73-76	apolipoprotein E	Homo sapiens	20-36
9931508-8	1999	These Drosophila ribosomal protein L22 and L23a have additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which have a resemblance to the carboxy-terminal portion of histone H1.	Lysine	70-73	Ribosomal protein L22	Drosophila melanogaster	17-38
9891054-5	1999	In this study, we demonstrate that PCAF also acetylates p53 in vitro at a lysine residue distinct from that acetylated by p300 and thereby increases p53"s ability to bind to its cognate DNA site.	Lysine	74-80	tumor protein p53	Homo sapiens	56-59
9891054-5	1999	In this study, we demonstrate that PCAF also acetylates p53 in vitro at a lysine residue distinct from that acetylated by p300 and thereby increases p53"s ability to bind to its cognate DNA site.	Lysine	74-80	tumor protein p53	Homo sapiens	149-152
9891054-6	1999	We have generated antibodies to acetylated p53 peptides at either of the two lysine residues that are targeted by PCAF or p300 and have demonstrated that these antibodies are highly specific for both acetylation and the particular site.	Lysine	77-83	tumor protein p53	Homo sapiens	43-46
9891069-8	1999	We further observed that the HPK1 mutant HPK1-KD(M46), which encodes the kinase domain with a point mutation at lysine-46, and HPK1-PR blocked interleukin-2 (IL-2) induction in Jurkat T cells, suggesting that HPK1 signaling plays a critical role in IL-2 induction.	Lysine	112-118	interleukin 2	Homo sapiens	143-156
9891069-8	1999	We further observed that the HPK1 mutant HPK1-KD(M46), which encodes the kinase domain with a point mutation at lysine-46, and HPK1-PR blocked interleukin-2 (IL-2) induction in Jurkat T cells, suggesting that HPK1 signaling plays a critical role in IL-2 induction.	Lysine	112-118	interleukin 2	Homo sapiens	158-162
9931508-8	1999	These Drosophila ribosomal protein L22 and L23a have additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which have a resemblance to the carboxy-terminal portion of histone H1.	Lysine	70-73	Ribosomal protein L23A	Drosophila melanogaster	43-47
9878818-7	1999	The alpha-MSH is flanked at the C-terminus by Gly-Lys-Lys, representing an amidation signal.	Lysine	50-53	proopiomelanocortin	Homo sapiens	10-13
9882455-5	1999	Two sites in mCA V, Lys 91 and Tyr 131, located on the rim of the active-site cavity have been targeted for the introduction of these imidazole analogs.	Lysine	20-23	carbonic anhydrase 5a, mitochondrial	Mus musculus	13-18
9920725-2	1999	Specific changes by mutagenesis of a strictly conserved threonine (H) into lysine (K), proline (P) or alanine (A) at position 343 of the human VPAC1 receptor resulted in its constitutive activation with respect to cAMP production.	Lysine	75-81	vasoactive intestinal peptide receptor 1	Homo sapiens	143-157
9862972-0	1999	Role of the conserved lysine 80 in stabilisation of NF-kappaB p50 DNA binding.	Lysine	22-28	nuclear factor kappa B subunit 1	Homo sapiens	52-65
9862972-3	1999	However, it has been suggested that additional contacts which stabilise DNA binding are made by lysine residues located in the C-terminus of the flexible loop which connects A and B beta-sheets of the N-terminal domain of p50.	Lysine	96-102	nuclear factor kappa B subunit 1	Homo sapiens	222-225
9862972-7	1999	The lysine residue responsible for this interaction is K80 which is conserved in all NF-kappaB/Rel/Dorsal molecules.	Lysine	4-10	nuclear factor kappa B subunit 1	Homo sapiens	85-94
10028184-3	1999	The present study shows evidence for the formation of a covalent enzyme-substrate intermediate between a specific lysine residue (Lys350) of yeast deoxyhypusine synthase and the 4-aminobutyl moiety from spermidine.	Lysine	114-120	deoxyhypusine synthase	Saccharomyces cerevisiae S288C	147-169
9878818-7	1999	The alpha-MSH is flanked at the C-terminus by Gly-Lys-Lys, representing an amidation signal.	Lysine	54-57	proopiomelanocortin	Homo sapiens	10-13
10029200-7	1999	Structural analysis by mass spectrometry of the tryptic digestion fractions of adducted cyt c is consistent with several peptides bearing one-to-three acetaldehyde moieties on Lys residues, and three distinct Tyr/Trp-containing peptides: P[28-53], P[56-73], P[73-91] carrying one-to-two HER.	Lysine	176-179	cytochrome c, somatic	Homo sapiens	88-93
10614048-7	1999	MAS-NMR analysis of [15N]lysine-labelled rhodopsin reveals the presence of a "soft" counterion, requiring intermediate water molecules for stabilization.	Lysine	25-31	rhodopsin	Homo sapiens	41-50
10199666-7	1999	This Dap3(AMPA), Asp10 bridge was about as effective as two Lys(i), Asp(i+4) lactam bridges incorporated linking residues 3 and 7, and 10 and 14, in the same model peptide sequence.	Lysine	60-63	death associated protein 3	Homo sapiens	5-9
10234804-9	1999	The importance of enhanced cell-cell interaction in the chondroinductive effects of BMP-2 on high-density C3H10T1/2 cultures was further implicated by the additional promotion of chondrogenesis in the presence of the polycationic compound, poly-L-lysine, which has been previously reported to enhance cellular interactions and chondrogenesis in embryonic limb mesenchymal cells.	Lysine	240-253	bone morphogenetic protein 2	Mus musculus	84-89
9920509-7	1999	In competition experiments, LDL, apoE, polymers of lysine and arginine were all capable of preventing the lipase specific [125I]Lp(a) retention.	Lysine	51-57	apolipoprotein E	Homo sapiens	33-37
9894014-2	1999	Our previous studies indicated that p-hydroxyphenylacetaldehyde (pHA), the major product of L-tyrosine oxidation by the myeloperoxidase/hydrogen peroxide/chloride system of phagocytes, covalently modifies the epsilon-amino group of lysine residues at sites of inflammation.	Lysine	232-238	myeloperoxidase	Homo sapiens	120-135
10536878-5	1999	These data emphasize the hypothesis that ACE inhibitors act with mixed-type inhibition, which is consistent with their slow-tight binding to the ACE active center, also with binding of chloride on a critical lysine residue leading to a potential conformational change, and finally with the fact that ACE has two domains, each bearing one catalytic site.	Lysine	208-214	angiotensin I converting enzyme	Homo sapiens	41-44
10071778-2	1999	The peptidic oligomers were made by linking several copies of the alpha-MSH fragment analog Nle-Asp-His-[D-Phe]-Arg-Trp-Lys-NH2 to different templates through formation of oxime bonds.	Lysine	120-123	proopiomelanocortin	Homo sapiens	66-75
10071789-1	1999	This presentation will trace the serendipitous discovery of novel vasopressin (VP) hypotensive agonists d(CH2)5[D-Tyr(Et)2,X3]VAVP (where X = Arg, Lys).	Lysine	147-150	arginine vasopressin	Homo sapiens	66-77
10071789-1	1999	This presentation will trace the serendipitous discovery of novel vasopressin (VP) hypotensive agonists d(CH2)5[D-Tyr(Et)2,X3]VAVP (where X = Arg, Lys).	Lysine	147-150	arginine vasopressin	Homo sapiens	79-81
9852036-14	1998	Mutagenic analyses suggested that this conjugation was formed via an isopeptide bond between the C-terminal glycine of hApg12 and Lys-130 of hApg5.	Lysine	130-133	autophagy related 5	Homo sapiens	141-146
10051177-9	1999	Insulin lispro, a recombinant insulin analogue, is identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 in the C-terminus of the B chain.	Lysine	122-128	insulin	Homo sapiens	0-7
10209874-2	1999	Release of the C-terminal lysine from Lys-C peptides by carboxypeptidase B and subsequent N-terminal acetylation of the resulting peptides leads to predictable shifts of the C- and N-terminal fragment ions in Matrix-assisted laser desorption/ionisation time-of-flight post-source decay mass spectra and facilitates the correct assignment of mostly complete amino acid sequences for oligopeptides.	Lysine	26-32	Lysozyme C	Drosophila melanogaster	38-43
9852036-4	1998	The C-terminal glycine of a novel modifier protein, Apg12p, is conjugated to a lysine residue of Apg5p via an isopeptide bond.	Lysine	79-85	autophagy related 12	Homo sapiens	52-58
9852036-4	1998	The C-terminal glycine of a novel modifier protein, Apg12p, is conjugated to a lysine residue of Apg5p via an isopeptide bond.	Lysine	79-85	autophagy related 5	Homo sapiens	97-102
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Lysine	222-225	insulin like growth factor binding protein 5	Homo sapiens	60-67
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Lysine	222-225	insulin like growth factor binding protein 5	Homo sapiens	188-195
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Lysine	240-243	insulin like growth factor binding protein 5	Homo sapiens	60-67
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Lysine	240-243	insulin like growth factor binding protein 5	Homo sapiens	188-195
9836589-9	1998	In addition, a deletion mutant of the p11 subunit, missing the last two C-terminal lysine residues, retained only about 15% of the activity of the wild-type p11 subunit.	Lysine	83-89	S100 calcium binding protein A10	Homo sapiens	38-41
9837944-1	1998	Among the polar interactions occurring in pancreatic lipase/colipase binding, only one ion pair involving lysine 400 on lipase and glutamic acid 45 on colipase has been described.	Lysine	106-112	pancreatic lipase	Equus caballus	53-59
9836589-11	1998	These results, therefore, suggest that the C-terminal lysine residues of the p11 subunit bind plasminogen and participate in the stimulation of t-PA-dependent activation of plasminogen by AIIt.	Lysine	54-60	S100 calcium binding protein A10	Homo sapiens	77-80
9836589-11	1998	These results, therefore, suggest that the C-terminal lysine residues of the p11 subunit bind plasminogen and participate in the stimulation of t-PA-dependent activation of plasminogen by AIIt.	Lysine	54-60	plasminogen activator, tissue type	Homo sapiens	144-148
9792715-12	1998	These studies indicate that the DHPR II-III and III-IV loops bind to contiguous and possibly overlapping sites on RyR1 between Lys 954 and Asp1112.	Lysine	127-130	quinoid dihydropteridine reductase	Homo sapiens	32-36
9875639-8	1998	Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production.	Lysine	267-275	tumor necrosis factor	Rattus norvegicus	37-64
9813304-3	1998	Several minor variants of SP-C exist, formed from N-terminal truncation, lysine palmitoylation, methionine oxidation and C-terminal esterification.	Lysine	73-79	surfactant protein C	Homo sapiens	26-30
9894848-4	1998	The results confirmed a previous pool sequencing study of HLA-A*1101 binding self-peptides, which showed that Lys at the C-terminus and Val, Ile, Phe, Tyr, and Thr at P2 are anchor residues for HLA-A*1101.	Lysine	110-113	major histocompatibility complex, class I, A	Homo sapiens	58-63
9894848-4	1998	The results confirmed a previous pool sequencing study of HLA-A*1101 binding self-peptides, which showed that Lys at the C-terminus and Val, Ile, Phe, Tyr, and Thr at P2 are anchor residues for HLA-A*1101.	Lysine	110-113	major histocompatibility complex, class I, A	Homo sapiens	194-199
9792715-12	1998	These studies indicate that the DHPR II-III and III-IV loops bind to contiguous and possibly overlapping sites on RyR1 between Lys 954 and Asp1112.	Lysine	127-130	ryanodine receptor 1	Homo sapiens	114-118
9841654-2	1998	We conducted guanidylation on lysine residues of cytochrome c by replacing their amino groups with homoarginine to enhance the protein-surfactant interaction.	Lysine	30-36	cytochrome c, somatic	Homo sapiens	49-61
9833038-0	1998	A glutamate to lysine mutation at the end of 2B rod domain of keratin 2e gene in ichthyosis bullosa of Siemens.	Lysine	15-21	keratin 2	Homo sapiens	62-72
9833038-6	1998	This mutation results in substitution of the codon for glutamic acid by a codon for lysine in position 493 in K2e (E493K).	Lysine	84-90	keratin 2	Homo sapiens	110-113
9815171-3	1998	For labeling the lysine residues of the model protein bovine serum albumin, the technetium methyl ester was saponified and then transformed into its N-hydroxysuccinimidyl ester.	Lysine	17-23	albumin	Homo sapiens	61-74
9841654-6	1998	In addition, a kinetic study demonstrated that guanidylation of lysine accelerated the initial extraction rate of cytochrome c.	Lysine	64-70	cytochrome c, somatic	Homo sapiens	114-126
9917090-2	1998	Here, we describe an improved immunogene system, in which the antigen-binding (Fab) fragments of the monoclonal antibody (Ab) B4G7 against the human EGFR were conjugated with poly-L-lysine to form a gene delivery vehicle (designated Fab "immunoporter").	Lysine	175-188	epidermal growth factor receptor	Homo sapiens	149-153
9783802-7	1998	In the present work, we sought to identify mutations in the codons 12/13 and 61 of RAS gene and in the Lys-1423 codon of GRD-NF1, which are well known hot spots in these genes, in a group of 36 adults and ten children with chronic myelogenous leukemia in chronic phase and blast crisis.	Lysine	103-106	neurofibromin 1	Homo sapiens	125-128
9758677-1	1998	Palmitoyl derivatives of interferon alpha2b (p-IFNalpha) were prepared by covalent attachment of the fatty acid to lysine residues in the protein through a reaction with N-hydroxysuccinimide palmitate ester.	Lysine	115-121	interferon alpha 1	Homo sapiens	47-55
9786921-10	1998	Active lysine residues in apolipoprotein B-100 (apoB-100) appear to be involved in the binding of LDL to PG, and, in fact, quantitative 13C NMR analysis revealed that, in the fused LDL particles, the number of active lysine residues per apoB-100 moiety was increased.	Lysine	7-13	apolipoprotein B	Homo sapiens	26-46
9786921-10	1998	Active lysine residues in apolipoprotein B-100 (apoB-100) appear to be involved in the binding of LDL to PG, and, in fact, quantitative 13C NMR analysis revealed that, in the fused LDL particles, the number of active lysine residues per apoB-100 moiety was increased.	Lysine	7-13	apolipoprotein B	Homo sapiens	48-56
9786921-10	1998	Active lysine residues in apolipoprotein B-100 (apoB-100) appear to be involved in the binding of LDL to PG, and, in fact, quantitative 13C NMR analysis revealed that, in the fused LDL particles, the number of active lysine residues per apoB-100 moiety was increased.	Lysine	7-13	apolipoprotein B	Homo sapiens	237-245
9786921-10	1998	Active lysine residues in apolipoprotein B-100 (apoB-100) appear to be involved in the binding of LDL to PG, and, in fact, quantitative 13C NMR analysis revealed that, in the fused LDL particles, the number of active lysine residues per apoB-100 moiety was increased.	Lysine	217-223	apolipoprotein B	Homo sapiens	26-46
9786921-10	1998	Active lysine residues in apolipoprotein B-100 (apoB-100) appear to be involved in the binding of LDL to PG, and, in fact, quantitative 13C NMR analysis revealed that, in the fused LDL particles, the number of active lysine residues per apoB-100 moiety was increased.	Lysine	217-223	apolipoprotein B	Homo sapiens	48-56
9790668-5	1998	Using a panel of 55 surface mutants of recombinant thrombin, we now show that the epitope for the IgG most likely includes Arg-101, Arg-233, and Lys-236 in exosite II.	Lysine	145-148	coagulation factor II, thrombin	Homo sapiens	51-59
9742144-3	1998	Chimeras and point mutations showed that, of the 52 nonidentical residues, a single residue at position 490 (threonine in rSERT and lysine in hSERT) governs this difference.	Lysine	132-138	solute carrier family 6 member 4	Homo sapiens	142-147
10068041-4	1998	Inspection of the structure of the complex suggested that it might be possible to convert the scFv into a bond-specific protease by the introduction of three catalytic residues: a glutamate to increase the nucleophilicity of a nearby water molecule, a lysine to increase the polarizability of the carbonyl group and a histidine to provide a proton to convert the amine into a better leaving group.	Lysine	252-258	immunglobulin heavy chain variable region	Homo sapiens	94-98
9774340-8	1998	In striking contrast, wild-type MyoD, in which all the internal Lys residues have been retained but the N-terminus has been extended by fusion of a short peptide, is stable both in vivo and in vitro.	Lysine	64-67	myogenic differentiation 1	Homo sapiens	32-36
9750163-1	1998	We studied the roles of Thr-136 (T136) and Glu-137 (E137) in the biogenesis of medium chain acyl-CoA dehydrogenase (MCAD) by altering the former to Ser (T136S), Asp (T136D), or Leu (T136L) and the latter to Asp (E137D), Gln (E137Q), or Lys (E137K).	Lysine	236-239	acyl-CoA dehydrogenase medium chain	Homo sapiens	79-114
9750163-1	1998	We studied the roles of Thr-136 (T136) and Glu-137 (E137) in the biogenesis of medium chain acyl-CoA dehydrogenase (MCAD) by altering the former to Ser (T136S), Asp (T136D), or Leu (T136L) and the latter to Asp (E137D), Gln (E137Q), or Lys (E137K).	Lysine	236-239	acyl-CoA dehydrogenase medium chain	Homo sapiens	116-120
9737992-6	1998	The glycated bovine serum albumin showed increased electrophoretic mobility suggesting that the basic residues, such as lysine, were modified by methylglyoxal.	Lysine	120-126	albumin	Homo sapiens	20-33
9809067-2	1998	We show that CBP and P/CAF acetylate HMG I(Y), the essential architectural component required for enhanceosome assembly, at distinct lysine residues, causing distinct effects on transcription.	Lysine	133-139	CREB binding protein	Homo sapiens	13-16
9759731-6	1998	The carboxy-terminal glycine residue of Apg12, a 186-amino-acid protein, is conjugated to a lysine at residue 149 of Apg5, a 294-amino-acid protein.	Lysine	92-98	Atg5p	Saccharomyces cerevisiae S288C	117-121
9736730-3	1998	Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.	Lysine	197-203	lysyl-tRNA synthetase 1	Homo sapiens	107-128
9737865-4	1998	The microenvironments (pKa) of Lys residues in apo B-100 in small, dense, intermediate, and light human LDL subspecies have been compared by 13C NMR, and the net surface charge of these particles has been characterized.	Lysine	31-34	apolipoprotein B	Homo sapiens	47-56
9726998-7	1998	This binding required Ca2+/Mg2+ ions, was lysine-mediated, and was markedly decreased in the presence of GAG-depleted decorin, suggesting the ionic nature of the interaction likely involving apoB100 and the GAG component of decorin.	Lysine	42-48	apolipoprotein B	Homo sapiens	191-198
9744860-4	1998	p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear localization signal.	Lysine	16-19	tumor protein p53	Homo sapiens	58-61
9744860-6	1998	Using a polyclonal antisera specific for p53 that is phosphorylated or acetylated at specific residues, we show that Lys-382 of human p53 becomes acetylated and Ser-33 and Ser-37 become phosphorylated in vivo after exposing cells to UV light or ionizing radiation.	Lysine	117-120	tumor protein p53	Homo sapiens	41-44
9744860-6	1998	Using a polyclonal antisera specific for p53 that is phosphorylated or acetylated at specific residues, we show that Lys-382 of human p53 becomes acetylated and Ser-33 and Ser-37 become phosphorylated in vivo after exposing cells to UV light or ionizing radiation.	Lysine	117-120	tumor protein p53	Homo sapiens	134-137
9727001-4	1998	A lysine at the equivalent position is present in only one of the known Kir subunits, the newly identified Kir1.3, which is also poorly expressed in the recombinant system.	Lysine	2-8	potassium inwardly rectifying channel subfamily J member 15	Homo sapiens	107-113
9727001-8	1998	Thus we postulate that in Kir1.3 channels the extracellular positively charged lysine is of crucial functional importance.	Lysine	79-85	potassium inwardly rectifying channel subfamily J member 15	Homo sapiens	26-32
9724528-0	1998	Replacement of lysine 45 by uncharged residues modulates the redox-Bohr effect in tetraheme cytochrome c3 of Desulfovibrio vulgaris (Hildenborough).	Lysine	15-21	cytochrome c, somatic	Homo sapiens	92-104
9707432-2	1998	BMP-4 is synthesized as an inactive precursor that is proteolytically activated by cleavage following the amino acid motif -Arg-Ser-Lys-Arg-.	Lysine	132-135	bone morphogenetic protein 4 L homeolog	Xenopus laevis	0-5
9710596-4	1998	Specifically, we observe decreased acetylation of histones H3 and H4 (preferentially lysines 5 and 12) that depends on the DNA-binding repressor (Ume6), Sin3, and Rpd3.	Lysine	85-92	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	163-167
9755897-4	1998	The self-association properties of these analogs were compared to those of human insulin and the rapid-acting insulin analog Lys(B28)Pro(B29)-human insulin.	Lysine	125-128	insulin	Homo sapiens	110-117
9755897-4	1998	The self-association properties of these analogs were compared to those of human insulin and the rapid-acting insulin analog Lys(B28)Pro(B29)-human insulin.	Lysine	125-128	insulin	Homo sapiens	110-117
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	Rac family small GTPase 2	Homo sapiens	95-99
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	Rac family small GTPase 2	Homo sapiens	161-165
9707432-4	1998	The proprotein convertases (PCs) are a family of seven structurally related serine endoproteases, at least one of which, furin, cleaves after the amino acid motif -Arg-X-Arg/Lys-Arg-.	Lysine	174-177	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	121-126
9733949-1	1998	To identify the roles of the two nucleotide-binding folds (NBFs) in the function of human P-glycoprotein, a multidrug transporter, we mutated the key lysine residues to methionines and the cysteine residues to alanines in the Walker A (WA) motifs (the core consensus sequence) in the NBFs.	Lysine	150-156	ATP binding cassette subfamily B member 1	Homo sapiens	90-104
9819895-9	1998	Upon receiving a variety of signals, many of which are probably mediated by the generation of reactive oxygen species (ROS), I kappa B-alpha undergoes phosphorylation, is then ubiquitinated at nearby lysine residues and finally degraded by the proteasome, while still complexed with NF- kappa B.	Lysine	200-206	NFKB inhibitor alpha	Homo sapiens	125-140
9694859-0	1998	Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting.	Lysine	0-6	cathepsin L	Homo sapiens	92-103
9694859-5	1998	Structural comparisons of the two lysine residues with those required for phosphorylation of cathepsin L, using models generated from recently acquired crystal structures, revealed several relevant similarities.	Lysine	34-40	cathepsin L	Homo sapiens	93-104
9694859-6	1998	On both molecules, the lysine residues were positioned approximately 34 A apart (34.06 A for cathepsin D and 33.80 A for cathepsin L).	Lysine	23-29	cathepsin L	Homo sapiens	121-132
9733949-3	1998	Mutation of the WA lysine or NEM binding cysteine in either of the NBFs blocked vanadate-induced nucleotide trapping of P-glycoprotein.	Lysine	19-25	ATP binding cassette subfamily B member 1	Homo sapiens	120-134
9690232-1	1998	BACKGROUND: LGE2 is produced by the cyclooxygenase- or free radical-mediated modification of arachidonate and is formed during the oxidation of low density lipoprotein (LDL) with subsequent adduction to lysine residues in apo B.	Lysine	203-209	apolipoprotein B	Homo sapiens	222-227
9723718-0	1998	Discrimination of conformational states of mitochondrial cytochrome P-450scc by selective modification of several Lys residues.	Lysine	114-117	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	57-76
9668079-3	1998	The specific activities of the URA7-encoded and URA8-encoded enzymes with a Glu161 --&gt; Lys (E161K) mutation were 2-fold greater when compared with the wild-type enzymes.	Lysine	90-93	CTP synthase URA7	Saccharomyces cerevisiae S288C	31-35
9700070-5	1998	The amino acid sequence of the VSF-1 DNA-binding basic domain has a Lys at position -10 instead of a conserved Arg found in the other bZIP factors isolated so far.	Lysine	68-71	transcription factor VSF-1	Solanum lycopersicum	31-36
9700070-6	1998	This lysine was found to be required for specific recognition of the non-palindromic binding site: a mutant VSF-1 with a Lys-to-Arg substitution at position -10 bound with higher affinity to a palindromic sequence than the wild-type protein.	Lysine	5-11	transcription factor VSF-1	Solanum lycopersicum	108-113
9700070-6	1998	This lysine was found to be required for specific recognition of the non-palindromic binding site: a mutant VSF-1 with a Lys-to-Arg substitution at position -10 bound with higher affinity to a palindromic sequence than the wild-type protein.	Lysine	121-124	transcription factor VSF-1	Solanum lycopersicum	108-113
9716150-1	1998	Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys--&gt;Asn).	Lysine	150-153	fibrinogen beta chain	Homo sapiens	113-123
9677415-0	1998	Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.	Lysine	24-30	tumor protein p53	Homo sapiens	104-107
9677415-6	1998	Mutagenesis analysis demonstrated that a single amino acid mutation of Lys-305 (mt p53) caused cytoplasmic sequestration of the p53 protein in the MCF-7 and RKO cells, whereas the fusion protein was distributed in both the cytoplasm and the nucleus of SAOS-2 cells.	Lysine	71-74	tumor protein p53	Homo sapiens	83-86
9677415-6	1998	Mutagenesis analysis demonstrated that a single amino acid mutation of Lys-305 (mt p53) caused cytoplasmic sequestration of the p53 protein in the MCF-7 and RKO cells, whereas the fusion protein was distributed in both the cytoplasm and the nucleus of SAOS-2 cells.	Lysine	71-74	tumor protein p53	Homo sapiens	128-131
9677415-10	1998	Lys-305 is needed for nuclear import of p53 protein, and amino acid residues 326-355 can sequester mt p53 in the cytoplasm.	Lysine	0-3	tumor protein p53	Homo sapiens	40-43
9677415-10	1998	Lys-305 is needed for nuclear import of p53 protein, and amino acid residues 326-355 can sequester mt p53 in the cytoplasm.	Lysine	0-3	tumor protein p53	Homo sapiens	102-105
9657985-8	1998	In conclusion, LDL may be a physiological regulator of haemostatic mechanisms through the interactions of lysine-rich domains of apo B-100 with tissue factor.	Lysine	106-112	apolipoprotein B	Homo sapiens	129-138
9657985-2	1998	A lysine-rich sequence within apo B-100 (residues 3121-3217), which we have termed lysine-rich apo B-100-derived (KRAD)-98 peptide, may be responsible for its activity.	Lysine	2-8	apolipoprotein B	Homo sapiens	30-39
9657985-2	1998	A lysine-rich sequence within apo B-100 (residues 3121-3217), which we have termed lysine-rich apo B-100-derived (KRAD)-98 peptide, may be responsible for its activity.	Lysine	2-8	apolipoprotein B	Homo sapiens	95-104
9697854-2	1998	The interaction requires all three domains of NSF but occurs between residues Lys-844 and Gln-853 of rat GluR2, with Asn-851 playing a critical role.	Lysine	78-81	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	46-49
9657985-2	1998	A lysine-rich sequence within apo B-100 (residues 3121-3217), which we have termed lysine-rich apo B-100-derived (KRAD)-98 peptide, may be responsible for its activity.	Lysine	83-89	apolipoprotein B	Homo sapiens	30-39
9657985-2	1998	A lysine-rich sequence within apo B-100 (residues 3121-3217), which we have termed lysine-rich apo B-100-derived (KRAD)-98 peptide, may be responsible for its activity.	Lysine	83-89	apolipoprotein B	Homo sapiens	95-104
9710993-2	1998	The natural sequence in human insulin at these positions is proline at B28 and lysine at B29.	Lysine	79-85	insulin	Homo sapiens	30-37
9701810-1	1998	The expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer.	Lysine	43-49	Lys14p	Saccharomyces cerevisiae S288C	158-163
9701810-1	1998	The expression of the structural genes for lysine (LYS) biosynthesis is controlled by a pathway-specific regulation mediated by the transcriptional activator Lys14 in the presence of alpha-aminoadipate semialdehyde, an intermediate of the pathway acting as a co-inducer.	Lysine	51-54	Lys14p	Saccharomyces cerevisiae S288C	158-163
9701810-3	1998	Analysis of LYS promoters and insertions within an heterologous reporter gene have allowed the characterization of an upstream activating element (UASLYS) able to confer Lys14- and alpha-amino-adipate semialdehyde-dependent activation as well as apparent repression by lysine to another yeast gene.	Lysine	269-275	Lys14p	Saccharomyces cerevisiae S288C	170-175
9697854-2	1998	The interaction requires all three domains of NSF but occurs between residues Lys-844 and Gln-853 of rat GluR2, with Asn-851 playing a critical role.	Lysine	78-81	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	105-110
9642086-0	1998	An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.	Lysine	7-10	RNA binding motif protein 8A	Homo sapiens	62-65
9642086-5	1998	Alanine scanning of TR13 has revealed that mutations in either Lys or Arg residues result in altered TAR-binding, and molecular modelling/docking experiments have shown that the two Arg residues of TR13 can interact with two appropriately spaced guanine residues in the upper-stem/loop of TAR.	Lysine	63-66	RNA binding motif protein 8A	Homo sapiens	101-104
9628846-6	1998	Recombinant proteins with mutations of K423E, Q427E and K429E showed reduced affinity for C4BP compared to plasma protein S, recombinant wild type protein S, or E424K-protein S. These results suggest that Lys-423, Gln-427 and Lys-429 of protein S are important for normal binding to C4BP.	Lysine	205-208	complement component 4 binding protein alpha	Homo sapiens	90-94
9614060-6	1998	However, the apparent affinity for lysine transport was 2.4 times lower in Cat1(-/-) cells when compared with wild type cells, a property characteristic of Cat3-mediated transport.	Lysine	35-41	dominant cataract 3	Mus musculus	156-160
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Lysine	101-107	insulin	Homo sapiens	0-7
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Lysine	101-107	insulin	Homo sapiens	54-61
9677011-1	1998	Insulin lispro is a newly developed analogue of human insulin where the positions of the amino acids lysine and proline have been switched at the end of the B chain of the insulin molecule.	Lysine	101-107	insulin	Homo sapiens	172-179
9677011-2	1998	Insulin lispro with lysine at position B28 and proline at position B29 has a weaker tendency for self-association than human insulin.	Lysine	20-26	insulin	Homo sapiens	0-7
9603949-2	1998	Coagulation factor XIIIa, plasma transglutaminase (endo-gamma-glutamine:epsilon-lysine transferase EC 2.3.2.13) catalyzes isopeptide bond formation between glutamine and lysine residues and rapidly cross-links fibrin clots.	Lysine	80-86	coagulation factor XIII A chain	Homo sapiens	0-49
9601073-3	1998	Two-dimensional 1H-13C NMR spectroscopy of the complexes formed by the derivatized cytochromes with cytochrome b5 and cytochrome c peroxidase has been used to investigate the number and identity of lysine residues of cytochrome c that are involved in interprotein interactions of cytochrome c. The NMR data are incompatible with simple static models proposed previously for the complexes formed by these proteins, but are consistent with the presence of multiple, interconverting complexes of comparable stability, consistent with studies employing Brownian dynamics to model the complexes.	Lysine	198-204	cytochrome b5 type A	Bos taurus	100-113
9628846-6	1998	Recombinant proteins with mutations of K423E, Q427E and K429E showed reduced affinity for C4BP compared to plasma protein S, recombinant wild type protein S, or E424K-protein S. These results suggest that Lys-423, Gln-427 and Lys-429 of protein S are important for normal binding to C4BP.	Lysine	205-208	complement component 4 binding protein alpha	Homo sapiens	283-287
9628846-6	1998	Recombinant proteins with mutations of K423E, Q427E and K429E showed reduced affinity for C4BP compared to plasma protein S, recombinant wild type protein S, or E424K-protein S. These results suggest that Lys-423, Gln-427 and Lys-429 of protein S are important for normal binding to C4BP.	Lysine	226-229	complement component 4 binding protein alpha	Homo sapiens	90-94
9630655-20	1998	V1 agonist-induced accumulation of [3H]IP1 was blocked by a selective V1a vasopressin receptor antagonist, (Phenylac1, D-Tyr(Me)2, Arg6,8, Lys-NH29)-vasopressin.	Lysine	139-142	arginine vasopressin	Homo sapiens	74-85
9643364-2	1998	We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405, Arg 407, Lys 409, Lys 415, and Lys 416) of avian LPL with asparagine.	Lysine	123-126	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	190-193
9643364-7	1998	Mutation of previously identified heparin-binding regions of LPL results in a relatively small decrease in heparin-binding affinity, as compared with mutations in this carboxyl-terminal region, indicating that Lys 321, Arg 405, Arg 407, Lys 409, and Lys 416 constitute the major heparin-binding domain in LPL.	Lysine	210-213	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	61-64
9580670-6	1998	Secondly, sequence analysis, together with allele-specific PCR and the amplification-created restriction site (ACRS) technique, revealed a dinucleotide TC--&gt;AG mutation, which changed isoleucine to lysine in the predicted first transmembrane domain of the EDNRB protein.	Lysine	201-207	endothelin receptor type B	Equus caballus	259-264
9620315-3	1998	Immunodominant regions (autoepitopes) on the porcine-PDC-E2 component have been mapped to two regions around Lys-46 (outer lipoyl domain) and Lys-173 (inner lipoyl domain), which contained covalently bound lipoic acid prosthetic group.	Lysine	109-112	dihydrolipoamide S-acetyltransferase	Homo sapiens	53-59
9620315-3	1998	Immunodominant regions (autoepitopes) on the porcine-PDC-E2 component have been mapped to two regions around Lys-46 (outer lipoyl domain) and Lys-173 (inner lipoyl domain), which contained covalently bound lipoic acid prosthetic group.	Lysine	142-145	dihydrolipoamide S-acetyltransferase	Homo sapiens	53-59
9643364-7	1998	Mutation of previously identified heparin-binding regions of LPL results in a relatively small decrease in heparin-binding affinity, as compared with mutations in this carboxyl-terminal region, indicating that Lys 321, Arg 405, Arg 407, Lys 409, and Lys 416 constitute the major heparin-binding domain in LPL.	Lysine	237-240	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	61-64
9643364-7	1998	Mutation of previously identified heparin-binding regions of LPL results in a relatively small decrease in heparin-binding affinity, as compared with mutations in this carboxyl-terminal region, indicating that Lys 321, Arg 405, Arg 407, Lys 409, and Lys 416 constitute the major heparin-binding domain in LPL.	Lysine	237-240	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	61-64
9585580-3	1998	We have investigated the source of proton transfer in a truncated form of mCA V and identified several basic residues, including Lys 91 and Tyr 131, located near the mouth of the active-site cavity that contribute to proton transfer.	Lysine	129-132	carbonic anhydrase 5a, mitochondrial	Mus musculus	74-79
9630655-20	1998	V1 agonist-induced accumulation of [3H]IP1 was blocked by a selective V1a vasopressin receptor antagonist, (Phenylac1, D-Tyr(Me)2, Arg6,8, Lys-NH29)-vasopressin.	Lysine	139-142	arginine vasopressin	Rattus norvegicus	149-160
9565609-9	1998	By site-directed mutagenesis the invariant lysine residue in the NTP-binding motif of CSB was substituted with a physicochemically related arginine.	Lysine	43-49	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	86-89
9575231-1	1998	The transmembrane topology of the serotonin transporter (SERT) has been examined by measuring the reactivity of selected lysine and cysteine residues with extracellular reagents.	Lysine	121-127	solute carrier family 6 member 4	Homo sapiens	34-55
9575231-1	1998	The transmembrane topology of the serotonin transporter (SERT) has been examined by measuring the reactivity of selected lysine and cysteine residues with extracellular reagents.	Lysine	121-127	solute carrier family 6 member 4	Homo sapiens	57-61
9650825-12	1998	Progress has been made with AcLys-[D-betaNal7, Ile8]desArg9-bradykinin (R 715) and Lys-Lys-[Hyp3, Cpg5, D-Tic7,Cpg8]desArg9-bradykinin (B 9958) which are pure B1 antagonists in humans and rabbits; both peptides have shown resistance to degradation by peptidases and have little if any, residual agonistic activity on mouse and rat B1 receptors.	Lysine	30-33	kininogen 1	Homo sapiens	60-70
9654080-4	1998	The interaction of the didomain with DNA is stabilized by the presence of the basic region (approximately 20 residues, 9 of which are Lys) that links the second HMG box to the acidic tail in intact HMG1; this may be, at least in part, why this region also enhances supercoiling of relaxed circular DNA by the didomain and circularization of short DNA fragments (in the presence of ligase).	Lysine	134-137	high mobility group box 1 pseudogene 5	Homo sapiens	198-202
9572873-12	1998	Together with the characterization of the adduct released from the inactivated DDC, these data suggest that the enzyme is inactivated by trapping the coenzyme in a ternary adduct with ketone and the active site lysine.	Lysine	211-217	dopa decarboxylase	Homo sapiens	79-82
9705070-4	1998	However, bacterial-overexpressed transcriptional factor IIB (TFIIB) was able to bind to both AF-2 and lysine-264 mutant hVDRs in vitro.	Lysine	102-108	general transcription factor IIB	Homo sapiens	61-66
9572303-5	1998	Transfection of human embryonic kidney 293 cells with the rat liver isoform of NAD(P)H:quinone oxidoreductase resulted in robust NADPH- and LY 83583-dependent staining that was completely blocked by dicumarol and was not observed in untransfected cells.	Lysine	140-142	crystallin zeta	Rattus norvegicus	87-109
9558358-10	1998	Kinetic determination of Kd values required the use of a fluorescently labeled calmodulin, 2-chloro-(epsilon-amino-Lys75)-[6-(4-N, N-diethylamino-phenyl)-1,3,5-triazin-4-yl]-calmodulin (TA-calmodulin).1 Since, as here, Lys75 is a convenient labeling site on calmodulin for the introduction of fluorescent probes, the biological activity of the Lys-modified calmodulins was evaluated.	Lysine	115-118	calmodulin 1	Homo sapiens	79-89
9621240-7	1998	In contrast, for cows fed rations supplemented with both ruminally protected Lys and ruminally protected Met, the production of both milk protein (40 g/d) and fat (40 g/d) was numerically increased to an extent that was consistent with earlier reported studies, although calculations did not indicate that performance was limited by intestinal supplies of Lys or Met.	Lysine	77-80	casein beta	Bos taurus	133-145
9588171-5	1998	The conversion may be accomplished by another protease(s) with a trypsin-like cleavage specificity, since it is unlikely that the mature TESP1 and TESP2 are capable of splitting the Lys-Ile bond between the light and heavy chains.	Lysine	182-185	protease, serine 39	Mus musculus	137-142
9572144-8	1998	A deletion of RPD3 or SIN3, but not of the related histone-deacetylase gene HDA1, results in increased acetylation of the lysine 5 residue of H4 in the promoters of the UME6-regulated INO1, IME2 and SPO13 genes.	Lysine	122-128	protein kinase IME2	Saccharomyces cerevisiae S288C	190-194
9572144-0	1998	Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3.	Lysine	61-67	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	87-91
9553060-7	1998	MDR1 variants with mutations of key lysine residues to methionines in the N-terminal or C-terminal nucleotide binding domains (K433M, K1076M, and K433M/K1076M), which bind but do not hydrolyze ATP, do not show nucleotide trapping either with or without the transported drug substrates.	Lysine	36-42	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
9572144-8	1998	A deletion of RPD3 or SIN3, but not of the related histone-deacetylase gene HDA1, results in increased acetylation of the lysine 5 residue of H4 in the promoters of the UME6-regulated INO1, IME2 and SPO13 genes.	Lysine	122-128	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	14-18
9537584-4	1998	We used here the mutated IGF-I-R with a lysine to arginine residue 1003 substitution, called IGF-I-KR, which carries a mutation in the ATP-binding domain of the intracellular beta subunit, while the extracellular, ligand binding alpha subunit remains unchanged.	Lysine	40-46	insulin like growth factor 1	Homo sapiens	25-30
9537584-4	1998	We used here the mutated IGF-I-R with a lysine to arginine residue 1003 substitution, called IGF-I-KR, which carries a mutation in the ATP-binding domain of the intracellular beta subunit, while the extracellular, ligand binding alpha subunit remains unchanged.	Lysine	40-46	insulin like growth factor 1	Homo sapiens	93-98
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	mitogen-activated protein kinase 1	Homo sapiens	46-49
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	34-37	parathyroid hormone	Homo sapiens	14-17
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	34-37	parathyroid hormone	Homo sapiens	189-192
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	46-49	parathyroid hormone	Homo sapiens	14-17
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	46-49	parathyroid hormone	Homo sapiens	189-192
9512553-8	1998	The naturally occurring WT1 isoforms with insertion of lysine, threonine and serine between zinc fingers three and four were unable to bind the selected RNAs.	Lysine	55-61	WT1 transcription factor	Homo sapiens	24-27
9507015-6	1998	Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression.	Lysine	17-30	mitogen-activated protein kinase 1	Homo sapiens	117-120
9556305-3	1998	All patients carried a mutation of an evolutionarily conserved asparagine residue to a lysine at position 480 (N480K) in the olfactomedin-homology domain, which is encoded by the third exon of the GLC1A gene.	Lysine	87-93	myocilin	Homo sapiens	197-202
9614577-5	1998	Complexes of the chimeric protein and plasmid DNA carrying a luciferase reporter gene, after condensation with poly-L-lysine resulted in an up to 150-fold increase in reporter gene expression in EGF receptor expressing cells in comparison to poly-L-lysine-DNA complexes alone.	Lysine	111-124	epidermal growth factor receptor	Homo sapiens	195-207
9614577-5	1998	Complexes of the chimeric protein and plasmid DNA carrying a luciferase reporter gene, after condensation with poly-L-lysine resulted in an up to 150-fold increase in reporter gene expression in EGF receptor expressing cells in comparison to poly-L-lysine-DNA complexes alone.	Lysine	242-255	epidermal growth factor receptor	Homo sapiens	195-207
9555005-2	1998	Oxidation of HDL3 was monitored by measuring the following parameters: (i) formation of conjugated dienes, (ii) production of thiobarbituric acid reactive substances (TBARS), (iii) decrease in reactive lysine and (iv) tryptophan residues, (v) change in particle charge and (vi) diameter, and (vii) oligomerisation of apoA-I and apoA-II.	Lysine	202-208	HDL3	Homo sapiens	13-17
9521691-0	1998	Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein.	Lysine	0-6	apolipoprotein B	Homo sapiens	54-70
9521691-10	1998	These studies indicated that lysine and arginine, but not aspartic and glutamic acid, residues are critical for apoB-MTP interactions, whereas histidine residues are not as critical.	Lysine	29-35	apolipoprotein B	Homo sapiens	112-116
9494104-10	1998	Both the Yap3 and Mkc7 proteases preferred to cleave at a single Glu-Lys downward arrow-Glu-Arg site.	Lysine	69-72	Yap3p	Saccharomyces cerevisiae S288C	9-13
9494104-11	1998	Analysis of secondary cleavage sites showed that Yap3 preferred to cleave after either Lys or Arg and Mkc7 after Lys.	Lysine	87-90	Yap3p	Saccharomyces cerevisiae S288C	49-53
9494104-11	1998	Analysis of secondary cleavage sites showed that Yap3 preferred to cleave after either Lys or Arg and Mkc7 after Lys.	Lysine	113-116	Yap3p	Saccharomyces cerevisiae S288C	49-53
9468544-7	1998	AIIt also stimulated the t-PA-dependent activation of [Lys]plasminogen about 28-fold.	Lysine	55-58	plasminogen activator, tissue type	Homo sapiens	25-29
9480926-10	1998	The COT peptide containing the FDNB-labelled lysine was isolated and sequenced.	Lysine	45-51	carnitine O-octanoyltransferase	Homo sapiens	4-7
9523665-1	1998	OBJECTIVE: To characterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK), Lys-bradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin, and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, noncholinergic (NANC) neurons supplying the cavernosal tissue.	Lysine	151-154	kininogen 1	Homo sapiens	155-165
9523665-1	1998	OBJECTIVE: To characterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK), Lys-bradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin, and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, noncholinergic (NANC) neurons supplying the cavernosal tissue.	Lysine	151-154	kininogen 1	Homo sapiens	155-165
9523665-1	1998	OBJECTIVE: To characterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK), Lys-bradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin, and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, noncholinergic (NANC) neurons supplying the cavernosal tissue.	Lysine	151-154	kininogen 1	Homo sapiens	155-165
9531056-8	1998	The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches.	Lysine	4-10	phospholipase A2 group IB	Homo sapiens	74-78
9531056-8	1998	The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches.	Lysine	126-132	phospholipase A2 group IB	Homo sapiens	154-158
9513600-12	1998	A complete [i-(i + 3)] scan of cyclo(i,i + 3)[MeTyr1,Ala15,Glui,Lys(i + 3),Nle27]-hGHRH(1-29)-NH2 was then produced in order to test the effects of a Glu-to-Lys lactam bridge at all points in the peptide.	Lysine	64-67	growth hormone releasing hormone	Homo sapiens	82-87
9480885-7	1998	Expression of rat jejunal 4F2hc in oocytes induced the lysine-inhibitable Na+-dependent influx of leucine and the leucine-inhibitable Na+-independent influx of lysine.	Lysine	55-61	solute carrier family 3 member 2	Rattus norvegicus	26-31
9480885-7	1998	Expression of rat jejunal 4F2hc in oocytes induced the lysine-inhibitable Na+-dependent influx of leucine and the leucine-inhibitable Na+-independent influx of lysine.	Lysine	160-166	solute carrier family 3 member 2	Rattus norvegicus	26-31
9499087-10	1998	CD4 degradation was also prevented by altering the four Lys residues in its cytosolic domain to Arg, suggesting a role for ubiquitination of one or more of these residues in the process of degradation.	Lysine	56-59	CD4 molecule	Homo sapiens	0-3
9544457-0	1998	Genetic variation in human serum albumin: a 313 Lys--&gt;Asn mutation in albumin reading identified by PCR analysis.	Lysine	48-51	albumin	Homo sapiens	33-40
9544457-0	1998	Genetic variation in human serum albumin: a 313 Lys--&gt;Asn mutation in albumin reading identified by PCR analysis.	Lysine	48-51	albumin	Homo sapiens	73-80
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Lysine	56-59	mitogen-activated protein kinase kinase 4	Homo sapiens	51-55
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Lysine	123-126	angiotensin I converting enzyme	Homo sapiens	242-245
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Lysine	123-126	kininogen 1	Homo sapiens	294-304
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Lysine	123-126	angiotensin I converting enzyme	Homo sapiens	337-340
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Lysine	56-59	mitogen-activated protein kinase 8	Homo sapiens	95-98
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Lysine	56-59	mitogen-activated protein kinase 8	Homo sapiens	125-128
9446578-10	1998	The ability of S100A11 to form multimers indicates that it also has a reactive lysine residue that functions as an amine donor.	Lysine	79-85	S100 calcium binding protein A11	Homo sapiens	15-22
9530523-8	1998	The results of these experiments demonstrate that: (1) there were mutations in p53 exon 5 and 8 in 35% (14 out of 40 samples) of human renal cancer tissues as revealed by PCR-SSCP analysis; (2) DNA sequencing of samples showing frame-shift have hot spot of p53 mutation on exon 8 at codon 244 (GGC--&gt;TGC) and exon 5 at codon 132 [AAG (Lys)--&gt;AGG (Arg)].	Lysine	338-341	tumor protein p53	Homo sapiens	79-82
9532503-4	1998	Milk yield increased with the corn distillers grains (34.3, 34.0, 35.3, and 36.7 kg/d for cows fed diets 1 through 4, respectively), especially when supplemented with ruminally protected Lys and Met.	Lysine	187-190	Weaning weight-maternal milk	Bos taurus	0-4
9430693-6	1998	delta hgprt transfectants containing amplified copies of a mutated HGPRT construct in which the Ser-Lys-Val COOH-terminal targeting signal had been deleted expressed HGPRT throughout the parasite, including subcellular organelles such as the nucleus and flagellum.	Lysine	100-103	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	6-11
9464251-5	1998	One case of exceptionally severe atherosclerosis combined with extensive intimal amyloid deposits showed an apoA1 deletion corresponding to Lys 107.	Lysine	140-143	apolipoprotein A1	Homo sapiens	108-113
9526032-0	1998	Ferrocyanide-peroxidase activity of cytochrome c oxidase Redox interaction of mitochondrial cytochrome c oxidase (COX) with ferrocyanide/ferricyanide couple is greatly accelerated by polycations, such as poly-l-lysine [Musatov et al.	Lysine	204-217	cytochrome c, somatic	Homo sapiens	36-48
9526032-0	1998	Ferrocyanide-peroxidase activity of cytochrome c oxidase Redox interaction of mitochondrial cytochrome c oxidase (COX) with ferrocyanide/ferricyanide couple is greatly accelerated by polycations, such as poly-l-lysine [Musatov et al.	Lysine	204-217	cytochrome c, somatic	Homo sapiens	92-104
9490000-7	1998	In combination with an X-ray crystal structure of human lysozyme, it is concluded that the adsorbing site of human lysozyme is at the back of the active site and that Arg-14, Lys-1, Arg-10 and Lys-13 play important roles in binding.	Lysine	193-196	lysozyme	Homo sapiens	115-123
9430678-7	1998	In synapsin I, the Ca2+ requirement for ATP binding is mediated by a single, evolutionarily conserved glutamate residue (Glu373) at a position where synapsin II contains a lysine residue.	Lysine	172-178	synapsin II	Homo sapiens	149-160
9430693-6	1998	delta hgprt transfectants containing amplified copies of a mutated HGPRT construct in which the Ser-Lys-Val COOH-terminal targeting signal had been deleted expressed HGPRT throughout the parasite, including subcellular organelles such as the nucleus and flagellum.	Lysine	100-103	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	67-72
9425043-2	1998	The basic amphiphilic segment Arg645-Arg-Arg-His-Ile-Val-Arg-Lys-Arg-Thr654-Leu-Arg-Arg-Le u-Leu-Gln 660, located within the cytoplasmic juxtamembrane domain of this receptor, was purified as a fusion protein with glutathione S-transferase and shown to bind calmodulin in a Ca2+-dependent manner.	Lysine	61-64	calmodulin 1	Homo sapiens	258-268
9472779-7	1998	Laminating the surface of the beads with poly-L-lysine and alginate provided an even more mechanically stable device that lasted for &gt;2 months instead of &lt;14 days in vivo and delivered &gt;20 ng of human growth hormone/ml of plasma within the first week.	Lysine	41-54	growth hormone 1	Homo sapiens	210-224
9422720-1	1998	Mutants of hexokinase I (Arg539 --&gt; Lys, Thr661 --&gt; Ala, Thr661 --&gt; Val, Gly534 --&gt; Ala, Gly679 --&gt; Ala, and Gly862 --&gt; Ala), located putatively in the vicinity of the ATP binding pocket, were constructed, purified to homogeneity, and studied by circular dichroism (CD) spectroscopy, fluorescence spectroscopy, and initial velocity kinetics.	Lysine	39-42	hexokinase 1	Homo sapiens	11-23
9454691-8	1998	Moreover, alteration of a lysine residue 18 amino acids from the recognized peptide prevented the interaction of MAb 13924 with the UL9 C-terminal DNA-binding domain.	Lysine	26-32	DNA replication origin-binding helicase	Human alphaherpesvirus 1	132-135
9922802-2	1998	Peroxidation of lipids in LDL, either initiated by radicals or catalysed by myeloperoxidase, results in the generation of aldehydes which substitute lysine residues in the apolipoprotein B-100 moiety and thus in the generation of oxidised LDL.	Lysine	149-155	myeloperoxidase	Homo sapiens	76-91
9922802-2	1998	Peroxidation of lipids in LDL, either initiated by radicals or catalysed by myeloperoxidase, results in the generation of aldehydes which substitute lysine residues in the apolipoprotein B-100 moiety and thus in the generation of oxidised LDL.	Lysine	149-155	apolipoprotein B	Homo sapiens	172-192
9522110-1	1998	The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin.	Lysine	47-50	insulin	Homo sapiens	14-21
9522110-1	1998	The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin.	Lysine	47-50	insulin	Homo sapiens	31-38
9522110-1	1998	The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin.	Lysine	47-50	insulin	Homo sapiens	31-38
9522110-1	1998	The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin.	Lysine	47-50	insulin	Homo sapiens	31-38
9504425-0	1998	Fluorescein 5"-isothiocyanate-modified Na+, K+ -ATPase, at Lys-501 of the alpha-chain, accepts ATP independent of pyridoxal 5"-diphospho-5"-adenosine modification at Lys-480.	Lysine	59-62	Fc gamma receptor and transporter	Homo sapiens	74-85
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Lysine	58-61	interleukin 1 beta	Homo sapiens	120-137
9506823-1	1998	The synthetic nonapeptide Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys corresponding to the amino acid sequence 163-171 of human interleukin-1beta (IL-1beta) has been reported to retain considerable immunostimulatory activity of the native protein without the induction of the inflammatory or pyrogenic responses.	Lysine	58-61	interleukin 1 beta	Homo sapiens	139-147
9504425-0	1998	Fluorescein 5"-isothiocyanate-modified Na+, K+ -ATPase, at Lys-501 of the alpha-chain, accepts ATP independent of pyridoxal 5"-diphospho-5"-adenosine modification at Lys-480.	Lysine	166-169	Fc gamma receptor and transporter	Homo sapiens	74-85
9460938-1	1998	Mutants of tobacco vein mottling virus (TVMV) with substitutions of Lys or Arg for Asp in the DAG motif at position 5 in the coat protein (CP) failed to infect tobacco plants systemically, but replicated and produced virions in protoplasts.	Lysine	68-71	golgi phosphoprotein 3	Homo sapiens	125-137
12174270-0	1998	Preparation and Biological Activity of [B(1)Ala, B(2)Ala, B(3)Lys]-Insulin.	Lysine	62-65	insulin	Homo sapiens	67-74
9443739-5	1998	The activities for plasmin of the plasmin inhibitor and bovine pancreatic trypsin inhibitor were reduced by conjugation, presumably because of a sensitive lysine residue in the structure of each of these two peptides.	Lysine	155-161	trophoblast Kunitz domain protein 1	Bos taurus	74-91
10608044-2	1998	Aspirin can nonenzymatically acetylate fibrinogen"s lysine residues, the functional groups most susceptible to oxidative modification.	Lysine	52-58	fibrinogen beta chain	Homo sapiens	39-49
10608044-5	1998	Exposure of fibrinogen to aspirin led to acetylation of lysine residues and inhibition of oxidation.	Lysine	56-62	fibrinogen beta chain	Homo sapiens	12-22
12174270-2	1998	[B(1)Ala, B(2)Ala, B(3)Lys]-Insulin retains full in vivo activity and receptor binding activity as insulin, but its lipogenesis activity and immunoactivity are 70 % and 0.88 % of those of insulin respectively.	Lysine	23-26	insulin	Homo sapiens	28-35
12174270-2	1998	[B(1)Ala, B(2)Ala, B(3)Lys]-Insulin retains full in vivo activity and receptor binding activity as insulin, but its lipogenesis activity and immunoactivity are 70 % and 0.88 % of those of insulin respectively.	Lysine	23-26	insulin	Homo sapiens	99-106
12174270-2	1998	[B(1)Ala, B(2)Ala, B(3)Lys]-Insulin retains full in vivo activity and receptor binding activity as insulin, but its lipogenesis activity and immunoactivity are 70 % and 0.88 % of those of insulin respectively.	Lysine	23-26	insulin	Homo sapiens	188-195
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Lysine	130-133	serpin family A member 1	Homo sapiens	154-157
9405486-3	1997	We recently reported biochemical evidence for a covalent enzyme-substrate intermediate involving a specific lysine residue (Lys329) in human deoxyhypusine synthase (Wolff, E. C., Folk, J. E., and Park, M. H. (1997) J. Biol.	Lysine	108-114	deoxyhypusine synthase	Homo sapiens	141-163
9405486-6	1997	In an effort to evaluate the role of this enzyme-substrate intermediate in catalysis, we carried out site-directed mutagenesis (Lys to Arg and/or Ala) of the conserved lysine residues in human deoxyhypusine synthase.	Lysine	128-131	deoxyhypusine synthase	Homo sapiens	193-215
9405486-6	1997	In an effort to evaluate the role of this enzyme-substrate intermediate in catalysis, we carried out site-directed mutagenesis (Lys to Arg and/or Ala) of the conserved lysine residues in human deoxyhypusine synthase.	Lysine	168-174	deoxyhypusine synthase	Homo sapiens	193-215
9398287-5	1997	Prothrombin contains +3 charge groups (Lys-2, Lys-11, Arg-10) that are absent from the GLA domain (residues 1-35) of protein Z, while protein Z contains -4 charge groups (Gla-11, Asp-34, Asp-35) that are absent in prothrombin.	Lysine	39-42	coagulation factor II, thrombin	Homo sapiens	0-11
9391065-1	1997	Two different mutations of the active-site Lys-296 in rhodopsin, K296E and K296M, have been found to cause autosomal dominant retinitis pigmentosa (ADRP).	Lysine	43-46	rhodopsin	Homo sapiens	54-63
9391065-3	1997	Previous work has highlighted the potential of retinylamine analogs as active-site directed inactivators of constitutively active mutants of rhodopsin with the idea that these or related compounds might be used therapeutically for cases of ADRP involving mutations of the active-site Lys.	Lysine	284-287	rhodopsin	Homo sapiens	141-150
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Lysine	21-24	angiotensin I converting enzyme	Homo sapiens	9-12
9548480-7	1997	In contrast, the leech alpha-MSH was flanked at its C-terminal by the Gly-Arg-Lys amidation signal.	Lysine	78-81	proopiomelanocortin	Homo sapiens	23-32
9401778-9	1997	A role for cyclic GMP as a mediator of chemotaxis was supported by the finding that the guanylyl cyclase inhibitor LY 83583 (100 microM) completely inhibited chemotaxis and suppressed the maximal response; EC50 for fMLP 32.53 +/- 11.18 and 85.21 +/- 15.14 pmol/10(6) cells with and without LY 83583, respectively.	Lysine	115-117	formyl peptide receptor 1	Homo sapiens	215-219
9409221-10	1997	Modification of LDL arginine and lysine residues abolished the ability of the lipoprotein to interact with APG, a finding that supports the hypothesis that the interaction is dependent on key positively charged amino acids on apoB.	Lysine	33-39	apolipoprotein B	Homo sapiens	226-230
9426183-9	1997	Upon receiving a variety of signals, many of which are probably mediated by the generation of reactive oxygen species (ROS), IkappaB-alpha undergoes phosphorylation at serine residues by a ubiquitin-dependent protein kinase, is then ubiquitinated at nearby lysine residues and finally degraded by the proteasome, probably while still complexed with NF-kappaB.	Lysine	257-263	NFKB inhibitor alpha	Homo sapiens	125-138
9400368-9	1997	The presence of Lys 40 in S1" of human chymase explains its preference for Asp/Glu at P1".	Lysine	16-19	chymase 1	Homo sapiens	39-46
9768470-6	1997	Purified human fibrinogen, together with 15-nm colloidal gold particles serving as an internal calibration standard, were adhered to a poly-L-lysine substrate on freshly cleaved mica.	Lysine	135-148	fibrinogen beta chain	Homo sapiens	15-25
9360549-8	1997	The tryptophan (Trp) at position 291 and lysine (Lys) at position 382 in human DAX-1 protein are highly conserved among other related orphan nuclear receptor superfamily members.	Lysine	41-47	nuclear receptor subfamily 0 group B member 1	Homo sapiens	79-84
9520124-4	1997	We also determined that r-apo(a) binds directly to a synthetic apoB peptide spanning amino acid residues 3732-3745; this interaction appeared to be mediated by sequences present in apo(a) kringle IV types 8 and 9, and could be inhibited by arginine, lysine and proline.	Lysine	250-256	apolipoprotein B	Homo sapiens	63-67
9362376-6	1997	The cluster mannoside with six mannose residues connected with a backbone of five lysine groups (M6L5) was, like unlabeled t-PA, able to inhibit 125I-t-PA degradation in the nmol/L range, while the mannoside M5L4 inhibited 125I-t-PA degradation in the micromol/L range.	Lysine	82-88	plasminogen activator, tissue type	Homo sapiens	150-154
9362376-6	1997	The cluster mannoside with six mannose residues connected with a backbone of five lysine groups (M6L5) was, like unlabeled t-PA, able to inhibit 125I-t-PA degradation in the nmol/L range, while the mannoside M5L4 inhibited 125I-t-PA degradation in the micromol/L range.	Lysine	82-88	plasminogen activator, tissue type	Homo sapiens	150-154
9434806-0	1997	Safety and efficacy of [Lys(B28), Pro(B29)]-human insulin in patients with diabetes mellitus.	Lysine	24-27	MIS18 kinetochore protein A	Homo sapiens	28-31
9434806-0	1997	Safety and efficacy of [Lys(B28), Pro(B29)]-human insulin in patients with diabetes mellitus.	Lysine	24-27	insulin	Homo sapiens	50-57
9360549-8	1997	The tryptophan (Trp) at position 291 and lysine (Lys) at position 382 in human DAX-1 protein are highly conserved among other related orphan nuclear receptor superfamily members.	Lysine	49-52	nuclear receptor subfamily 0 group B member 1	Homo sapiens	79-84
9360549-11	1997	These findings suggest that: 1) Trp at position 291 and Lys at position 382, located in the C-terminal presumptive ligand binding domain, are important to the functional role of the DAX-1 protein in adrenal embryogenesis and/or in hypothalamic-pituitary activity; and 2) molecular analysis of the DAX-1 gene may help genetic counseling, even in cases with deletion mutation, because a detection of de novo deletion may exclude another affected or carrier child.	Lysine	56-59	nuclear receptor subfamily 0 group B member 1	Homo sapiens	182-187
9343429-5	1997	In contrast, substitution of a lysine residue in the N-terminal arm of the Phox1 homeodomain appeared to abolish DNA binding without affecting activity in vivo.	Lysine	31-37	paired related homeobox 1	Homo sapiens	75-80
9390440-8	1997	This notion is further supported by the fact that in floury2, another high-Lys mutant, the content of eEF1A increases with the dosage of the floury2 gene.	Lysine	75-78	prolamin 22 kDa alpha zein z1C2	Zea mays	53-60
9390440-8	1997	This notion is further supported by the fact that in floury2, another high-Lys mutant, the content of eEF1A increases with the dosage of the floury2 gene.	Lysine	75-78	prolamin 22 kDa alpha zein z1C2	Zea mays	141-148
9334265-2	1997	In oocyte injection assays, CAT3 cRNA exhibited a saturable, sodium ion-independent transport activity with high affinity for L-arginine and L-lysine (Km = 40-60 and 115-165 microM, respectively).	Lysine	141-149	dominant cataract 3	Mus musculus	28-32
9357532-0	1997	Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu-Lys bridges.	Lysine	74-77	corticotropin releasing hormone	Rattus norvegicus	12-42
9392078-1	1997	In Saccharomyces cerevisiae, an intermediate of the lysine pathway, alpha-aminoadipate semialdehyde (alpha AASA), acts as a coinducer for the transcriptional activation of LYS genes by Lys14p.	Lysine	52-58	Lys14p	Saccharomyces cerevisiae S288C	185-191
9392078-5	1997	The effects of lys80 mutations on LYS genes expression were dependent on the integrity of the activation system (Lys14p and alpha AASA).	Lysine	34-37	Lys14p	Saccharomyces cerevisiae S288C	113-119
9268623-4	1997	Lungfish insulin also contains amino acid substitutions such as Gly --&gt; Ala at position B-21, Glu --&gt; Asp at position B-22, and a Lys --&gt; Ser residue at position B-30, previously found in insulins from amphibia.	Lysine	136-139	insulin	Homo sapiens	9-16
9336414-5	1997	RESULTS: Pauciarticular, but not polyarticular, JRA patient sera were found to recognize a lysine-rich major epitope (KKGKKKDP), which is located in the linker region of the HMG box domains of the HMG-2 nonhistone chromosomal protein.	Lysine	91-97	high mobility group box 2	Homo sapiens	197-202
9364984-3	1997	PNS-substrates which contain Lys in the P1 position are specific for Lys-plasmin and are either not hydrolyzed or hydrolyzed at a relatively low rate by factor Xa, thrombin, or urokinase-type plasminogen activator (uPA).	Lysine	29-32	plasminogen activator, urokinase	Homo sapiens	177-213
9364984-3	1997	PNS-substrates which contain Lys in the P1 position are specific for Lys-plasmin and are either not hydrolyzed or hydrolyzed at a relatively low rate by factor Xa, thrombin, or urokinase-type plasminogen activator (uPA).	Lysine	29-32	plasminogen activator, urokinase	Homo sapiens	215-218
9307017-11	1997	Evidence of an essential lysine residue located in or near the coenzyme binding site has been obtained from chemical modification of aldose reductase with pyridoxal 5"-phosphate.	Lysine	25-31	aldo-keto reductase family 1 member B	Homo sapiens	133-149
9275185-7	1997	Interestingly, deletion of amino acids 353-835 in the putative C-terminal regulatory region, or mutation of Lys-35 in the putative ATP-binding domain, markedly reduced the ability of GLK to activate JNK.	Lysine	108-111	mitogen-activated protein kinase 8	Homo sapiens	199-202
9352079-4	1997	The experimental results and theoretical analysis suggested that the main contribution to heat stabilization of CPA is related to intramolecular electrostatic interactions and Arginine and/or Lysine are the putative groups able to bind phosphate and stabilize the enzyme molecule against thermal denaturation.	Lysine	192-198	carboxypeptidase A1	Homo sapiens	112-115
9375972-18	1997	Contrastingly, L-lysine has no effects in the absence of endotoxin and thus appears to act as a selective modulator of iNOS activity.	Lysine	15-23	nitric oxide synthase 2	Rattus norvegicus	119-123
9339963-1	1997	Insulin lispro, a recombinant insulin analogue, is identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 in the C-terminus of the B chain.	Lysine	122-128	insulin	Homo sapiens	0-7
9410884-1	1997	Tissue transglutaminase (tTgase, type II) is a Ca2+-dependent GTP binding protein which crosslinks proteins via (epsilon)((gamma)-glutamyl)lysine bridges.	Lysine	139-145	transglutaminase 2	Homo sapiens	0-23
9287308-2	1997	Rhodopsin consists of the opsin apoprotein and its 11-cis-retinal chromophore, which is covalently bound to a specific lysine residue by a stable protonated Schiff base linkage.	Lysine	119-125	rhodopsin	Homo sapiens	0-9
9283096-2	1997	Previous studies of fluoresceinated transferrin have suggested Lys 569 as a kinetically active site in the C-terminal lobe of the protein.	Lysine	63-66	transferrin	Homo sapiens	36-47
9410552-4	1997	The Lilly Laboratories, by inverting the amino acids lysine and proline in positions 28 and 29 in the B chain, have created an insulin (Lispro) which more rapidly dissociates into monomers after injection.	Lysine	53-59	insulin	Homo sapiens	127-134
9294870-0	1997	Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.	Lysine	66-72	superoxide dismutase 1	Homo sapiens	126-152
15991899-1	1997	Insulin lispro (Humalog) is a biosynthetic insulin analogue in which the positions of proline and lysine are reversed in the C-terminal portion of the B chain.	Lysine	98-104	insulin	Homo sapiens	0-7
15991899-1	1997	Insulin lispro (Humalog) is a biosynthetic insulin analogue in which the positions of proline and lysine are reversed in the C-terminal portion of the B chain.	Lysine	98-104	insulin	Homo sapiens	43-50
9294870-1	1997	Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide, Lys-136, along with the adjacent residues Glu-132 and Glu-133, forms a proposed electrostatic triad contributing to substrate recognition.	Lysine	221-224	superoxide dismutase 1	Homo sapiens	24-50
9294870-1	1997	Key charged residues in Cu,Zn superoxide dismutase (Cu,Zn SOD) promote electrostatic steering of the superoxide substrate to the active site Cu ion, resulting in dismutation of superoxide to oxygen and hydrogen peroxide, Lys-136, along with the adjacent residues Glu-132 and Glu-133, forms a proposed electrostatic triad contributing to substrate recognition.	Lysine	221-224	superoxide dismutase 1	Homo sapiens	52-61
9294870-8	1997	Multiple-site titration analysis showed that deprotonation events throughout the enzyme are likely responsible for the gradual decrease in SOD activity above pH 9.5 and predicted a pKa value of 11.7 for Lys-136.	Lysine	203-206	superoxide dismutase 1	Homo sapiens	139-142
9277436-2	1997	A molecular conjugate consisting of a synthetic peptide (C1315) based on the SECR binding motif of human alpha 1-AT covalently coupled to poly-L-lysine was used to introduce reporter genes into hepatoma cell lines in culture.	Lysine	138-151	serpin family A member 1	Homo sapiens	105-115
9305622-0	1997	Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.	Lysine	0-6	plasminogen activator, tissue type	Homo sapiens	56-59
9305622-0	1997	Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.	Lysine	0-6	plasminogen activator, tissue type	Homo sapiens	107-110
9305787-1	1997	Custom designed analogs of the natural anti-bacterial peptide cecropin B (CB) have been synthesized; cecropin B-1 (CB-1) was constructed by replacing the C-terminal segment (residues 26 to 35) with the N-terminal sequence of CB (positions 1 to 10 which include five lysine residues).	Lysine	266-272	cannabinoid receptor 1	Homo sapiens	101-119
9261142-6	1997	The increased electrophoretic mobility of oxidized LDL reflects modification of the lysine residues of apolipoprotein B-100 (apoB-100).	Lysine	84-90	apolipoprotein B	Homo sapiens	103-123
9261142-6	1997	The increased electrophoretic mobility of oxidized LDL reflects modification of the lysine residues of apolipoprotein B-100 (apoB-100).	Lysine	84-90	apolipoprotein B	Homo sapiens	125-133
9261142-9	1997	In contrast, if the lysine residues of apoB-100 were methylated to shield them against oxidative modification, subsequent treatment of LDL with copper sulfate failed to reduce the degree of LDL binding to proteoglycans.	Lysine	20-26	apolipoprotein B	Homo sapiens	39-47
9261142-12	1997	The present results show that, after modification of the lysine residues of apoB-100 during oxidation, the binding of LDL to proteoglycans is decreased, and suggest that oxidation of LDL tends to lead to intracellular rather than extracellular accumulation of LDL during atherogenesis.	Lysine	57-63	apolipoprotein B	Homo sapiens	76-84
9202012-0	1997	p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues.	Lysine	182-188	myeloperoxidase	Homo sapiens	78-93
9288920-13	1997	Thus, the involvement of lysine residues in the gating of the RyR channel is proposed.	Lysine	25-31	ryanodine receptor 1	Homo sapiens	62-65
9211897-3	1997	HDL and dimyristoyl phosphatidylcholine binding assays using the variant apoA-I forms have shown that replacement of specific carboxyl-terminal hydrophobic residues Leu222, Phe225, and Phe229 with lysines, as well as replacement of Leu211, Leu214, Leu218, and Leu219 with valines, diminished the ability of apoA-I to bind to HDL and to lyse dimyristoyl phosphatidylcholine liposomes.	Lysine	197-204	apolipoprotein A1	Homo sapiens	73-79
9202012-6	1997	The compound Nepsilon-(2-(p-hydroxyphenyl)ethyl)lysine (pHA-lysine) was likewise identified in acid hydrolysates of bovine serum albumin (BSA) that were first exposed to myeloperoxidase, H2O2, L-tyrosine, and Cl- and then reduced with NaCNBH3.	Lysine	48-54	albumin	Homo sapiens	123-136
9202012-6	1997	The compound Nepsilon-(2-(p-hydroxyphenyl)ethyl)lysine (pHA-lysine) was likewise identified in acid hydrolysates of bovine serum albumin (BSA) that were first exposed to myeloperoxidase, H2O2, L-tyrosine, and Cl- and then reduced with NaCNBH3.	Lysine	48-54	myeloperoxidase	Homo sapiens	170-185
9202012-11	1997	pHA-lysine formation required L-tyrosine and cell activation; it was inhibited by peroxidase inhibitors and catalase, implicating myeloperoxidase and H2O2 in the reaction pathway.	Lysine	4-10	myeloperoxidase	Homo sapiens	130-145
9271317-2	1997	The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT, with promiscuous binding to multiple MHC class II alleles, reduces the incidence, onset and severity of disease in the BIO.D2 --&gt; BALB/c model of lethal GVHD.	Lysine	58-63	galactose mutarotase	Homo sapiens	89-93
9210374-7	1997	Stimulation of CED-3-dependent apoptosis by CED-4 was accompanied by accelerated processing of CED-3, which was dependent on the presence of a wild-type CED-3 prodomain and a conserved lysine residue within a putative ATP/GTP-binding motif of CED-4.	Lysine	185-191	Cell death protein 3 subunit p17	Caenorhabditis elegans	15-20
9210374-7	1997	Stimulation of CED-3-dependent apoptosis by CED-4 was accompanied by accelerated processing of CED-3, which was dependent on the presence of a wild-type CED-3 prodomain and a conserved lysine residue within a putative ATP/GTP-binding motif of CED-4.	Lysine	185-191	Cell death protein 3 subunit p17	Caenorhabditis elegans	95-100
9210374-7	1997	Stimulation of CED-3-dependent apoptosis by CED-4 was accompanied by accelerated processing of CED-3, which was dependent on the presence of a wild-type CED-3 prodomain and a conserved lysine residue within a putative ATP/GTP-binding motif of CED-4.	Lysine	185-191	Cell death protein 3 subunit p17	Caenorhabditis elegans	95-100
9282167-5	1997	Finally, we show that incorporation of transferrin into an artificial virus consisting of poly-L-lysine-condensed DNA coated with a lipid shell (LPDII formulation) results in ligand-directed delivery of DNA to myogenic cells.	Lysine	90-103	transferrin	Homo sapiens	39-50
9215742-5	1997	This protein, GAL4/Inv, together with poly-L-lysine, formed complexes with a chloramphenicol acetyltransferase (CAT) reporter plasmid that contains eight repeats of the GAL4 consensus recognition sequence.	Lysine	38-51	putative invertase	Escherichia coli	19-22
9271318-1	1997	When examining anchor residues of a peptide 0405BP2 (1SPGTGAYYVLLN12) that was eluted from purified HLA-DR4 molecules (DRA/DRB1*0405), we found that heptamer peptides K7YYVLLN12 and K7YAALAN12 could bind to DR4 with the same affinity as 0405BP2, where artificially added Lys increases the solubility of peptides, and 7Y, 10L and 12N function as major anchor residues.	Lysine	271-274	solute carrier family 26 member 3	Homo sapiens	119-122
9271318-1	1997	When examining anchor residues of a peptide 0405BP2 (1SPGTGAYYVLLN12) that was eluted from purified HLA-DR4 molecules (DRA/DRB1*0405), we found that heptamer peptides K7YYVLLN12 and K7YAALAN12 could bind to DR4 with the same affinity as 0405BP2, where artificially added Lys increases the solubility of peptides, and 7Y, 10L and 12N function as major anchor residues.	Lysine	271-274	major histocompatibility complex, class II, DR beta 1	Homo sapiens	123-127
9188485-0	1997	Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase.	Lysine	43-49	deoxyhypusine synthase	Homo sapiens	63-85
9211344-6	1997	In vitro glyoxylate inhibited VDR binding to the osteocalcin and osteopontin VDREs as assessed by electrophoretic mobility shift assay and the inhibition was reversed when glyoxylate was preincubated with lysine.	Lysine	205-211	bone gamma-carboxyglutamate protein	Rattus norvegicus	49-60
9192697-1	1997	The maize floury2 mutation results in the formation of a soft, starchy endosperm with a reduced amount of prolamin (zein) proteins and twice the lysine content of the wild type.	Lysine	145-151	prolamin 22 kDa alpha zein z1C2	Zea mays	10-17
9241594-8	1997	The first-limiting amino acid for milk protein synthesis was lysine for control diets and methionine for diets with supplemental fat.	Lysine	61-67	casein beta	Bos taurus	34-46
9241597-7	1997	For both cannulated and intact cows, Lys supplementation increased the percentage of milk protein, and milk protein yield was increased by Lys in intact cows.	Lysine	37-40	casein beta	Bos taurus	85-97
9241597-7	1997	For both cannulated and intact cows, Lys supplementation increased the percentage of milk protein, and milk protein yield was increased by Lys in intact cows.	Lysine	139-142	casein beta	Bos taurus	103-115
9188485-2	1997	Deoxyhypusine synthase catalyzes the formation of deoxyhypusine by conjugation of the butylamine moiety of spermidine to the epsilon-amino group of one specific lysine residue of the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein.	Lysine	161-167	deoxyhypusine synthase	Homo sapiens	0-22
9162088-8	1997	When both of the lysines of gammaB-crystallin were mutated to threonines (gammaB-K2T/K163T), the quantity of cross-linked products was greatly reduced, indicating that, despite the fact that the alpha-amino group is a major glycated site, epsilon-amino groups play a predominant role in cross-linking.	Lysine	17-24	crystallin gamma B	Bos taurus	28-45
9177225-4	1997	The gene encoding the C18-defined antigen was identified as a mutated form of a mouse mitogen-activated protein kinase, ERK2, and a peptide incorporating the resulting amino acid substitution (lysine to glutamine) was efficiently recognized by C18.	Lysine	193-199	mitogen-activated protein kinase 1	Mus musculus	120-124
9178696-8	1997	CONCLUSIONS: DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.	Lysine	169-175	major histocompatibility complex, class II, DR beta 1	Homo sapiens	13-17
9178696-8	1997	CONCLUSIONS: DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.	Lysine	169-175	major histocompatibility complex, class II, DR beta 1	Homo sapiens	27-31
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Lysine	129-132	histatin 3	Homo sapiens	9-11
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Lysine	129-132	histatin 3	Homo sapiens	16-18
9220009-3	1997	A change from a lysine in the N-terminus of BlaI to an alanine or deletion of the C-terminal 23 amino acids severely reduces its DNA-binding ability, demonstrating the functional importance of both the N- and C-termini.	Lysine	16-22	Beta-lactamase repressor BlaI	Staphylococcus aureus	44-48
9162088-11	1997	Our results also show that Lys-2 and Lys-163 play almost equal roles in cross-linking of gammaB-crystallin.	Lysine	27-30	crystallin gamma B	Bos taurus	89-106
9162088-11	1997	Our results also show that Lys-2 and Lys-163 play almost equal roles in cross-linking of gammaB-crystallin.	Lysine	37-40	crystallin gamma B	Bos taurus	89-106
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Lysine	189-192	coagulation factor II, thrombin	Homo sapiens	64-72
9153272-3	1997	A plausible mechanism for this inhibitory effect of thrombin involves TAFI (thrombin-activatable fibrinolysis inhibitor, procarboxypeptidase B) which, upon activation, may inhibit fibrinolysis by removing carboxy-terminal lysines from fibrin.	Lysine	222-229	coagulation factor II, thrombin	Homo sapiens	52-60
9153260-8	1997	Thrombin specifically cleaved chicken OPN at two sites: between Arg-22 and Ser-23, which generated the 5-kDa N-terminal end fragment, and another between Lys-138 and Ala-139, which generated the 30- and 20-kDa fragments.	Lysine	154-157	secreted phosphoprotein 1	Gallus gallus	38-41
9150244-2	1997	Analysis of the primary structure of Apo B-100 showed a higher than expected occurrence of lysine groups in the receptor-binding region.	Lysine	91-97	apolipoprotein B	Homo sapiens	37-46
9182989-0	1997	Human ribosomal protein L7 binds RNA with an alpha-helical arginine-rich and lysine-rich domain.	Lysine	77-83	ribosomal protein L7	Homo sapiens	6-26
9110988-8	1997	Lysine at helix position -1 of zinc finger 4 was conserved in all selected tz4-7 fusions.	Lysine	0-6	Yip1 domain family member 4	Homo sapiens	36-44
9153421-6	1997	After carbodiimide-mediated cross-linking, Lys-3 of thymosin beta 4 was cross-linked to Glu-167 of actin, and Lys-18 of thymosin beta 4 was cross-linked to one of the the N-terminal acidic residues of actin (Asp-1-Glu-4); the cross-linked actin residues lie within subdomains 3 and 1, respectively.	Lysine	43-46	thymosin beta 4 X-linked	Homo sapiens	52-67
9153421-6	1997	After carbodiimide-mediated cross-linking, Lys-3 of thymosin beta 4 was cross-linked to Glu-167 of actin, and Lys-18 of thymosin beta 4 was cross-linked to one of the the N-terminal acidic residues of actin (Asp-1-Glu-4); the cross-linked actin residues lie within subdomains 3 and 1, respectively.	Lysine	110-113	thymosin beta 4 X-linked	Homo sapiens	120-135
9153421-8	1997	After transglutaminase-mediated cross-linking, Lys-38 of thymosin beta 4 was cross-linked to Gln-41 of actin, placing the C-terminal region of thymosin beta 4 in contact with subdomain 2 on the pointed end; thymosin beta 4 may sterically block actin polymerization at the pointed end as well as the barbed end of the monomer.	Lysine	47-50	thymosin beta 4 X-linked	Homo sapiens	57-72
9153421-8	1997	After transglutaminase-mediated cross-linking, Lys-38 of thymosin beta 4 was cross-linked to Gln-41 of actin, placing the C-terminal region of thymosin beta 4 in contact with subdomain 2 on the pointed end; thymosin beta 4 may sterically block actin polymerization at the pointed end as well as the barbed end of the monomer.	Lysine	47-50	thymosin beta 4 X-linked	Homo sapiens	143-158
9153421-8	1997	After transglutaminase-mediated cross-linking, Lys-38 of thymosin beta 4 was cross-linked to Gln-41 of actin, placing the C-terminal region of thymosin beta 4 in contact with subdomain 2 on the pointed end; thymosin beta 4 may sterically block actin polymerization at the pointed end as well as the barbed end of the monomer.	Lysine	47-50	thymosin beta 4 X-linked	Homo sapiens	143-158
9111052-3	1997	Studies with peptide analogs showed that a lysine residue at position 1 (based on the lysylbradykinin sequence) of ligands was essential for high affinity binding to the human B1 receptor.	Lysine	43-49	bradykinin receptor B1	Homo sapiens	176-187
9150244-3	1997	In order to demonstrate the participation of lysine groups of Apo B-100 in the inhibition of thromboplastin, thromboplastin and Apo B-100 were incubated together in the presence of poly-L-lysine, poly-L-arginine, lysine and arginine monomers.	Lysine	45-51	apolipoprotein B	Homo sapiens	62-71
9150244-3	1997	In order to demonstrate the participation of lysine groups of Apo B-100 in the inhibition of thromboplastin, thromboplastin and Apo B-100 were incubated together in the presence of poly-L-lysine, poly-L-arginine, lysine and arginine monomers.	Lysine	45-51	apolipoprotein B	Homo sapiens	128-137
9150244-3	1997	In order to demonstrate the participation of lysine groups of Apo B-100 in the inhibition of thromboplastin, thromboplastin and Apo B-100 were incubated together in the presence of poly-L-lysine, poly-L-arginine, lysine and arginine monomers.	Lysine	188-194	apolipoprotein B	Homo sapiens	62-71
9150244-4	1997	The inhibition of thromboplastin by Apo B-100 was completely suppressed in the presence of poly-L-lysine.	Lysine	91-104	apolipoprotein B	Homo sapiens	36-45
9083028-7	1997	A CCK-BR mutant was further constructed by replacing five amino acids, Gly-Leu-Ser-Arg-(Arg)-Leu, in the first intracellular loop with the corresponding five CCK-AR specific amino acids, Ile-Arg-Asn-Lys-(Arg)-Met.	Lysine	199-202	cholecystokinin B receptor	Homo sapiens	2-8
9092503-10	1997	Our data suggests that an as yet uncharacterized endopeptidase(s) in the S. cerevisiae secretory pathway is responsible for the lysine-specific cleavage of pro-CCK.	Lysine	128-134	cholecystokinin	Homo sapiens	160-163
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Lysine	73-76	inorganic pyrophosphatase 1	Homo sapiens	47-50
9092533-5	1997	Recent observations suggest that phosphorylation of serines 32 and 36 and subsequent ubiquitination of lysines 21 and 22 of IkappaBalpha control its signal-induced degradation.	Lysine	103-110	NFKB inhibitor alpha	Homo sapiens	124-136
9149966-2	1997	Supplementation of Met and Lys increased the milk yield of cows previously fed the low RUP diet, but milk yields before and after amino acid (AA) supplementation were similar for cows previously fed the high RUP diet.	Lysine	27-30	Weaning weight-maternal milk	Bos taurus	45-49
9143230-12	1997	Heparin (50 U/ml) and dextran sulfate (200 mg/ml) restored endothelium-dependent relaxations to bradykinin (10(-10)-10(-6) M) in arteries exposed to poly-L-arginine (10(-6) M) or poly-L-lysine (10(-6) M).	Lysine	179-192	kininogen 1	Canis lupus familiaris	96-106
9092833-1	1997	To elucidate the minimum requirement of amino acid residues for the active center in human adenylate kinase (hAK1), we carried out random site-directed mutagenesis of key lysine residues (K9, K21, K27, K31, K63, K131, and K194), which were conserved in mammalian AK1 species, with the pMEX8-hAK1 plasmid [Ayabe, T., et al.	Lysine	171-177	adenylate kinase 1	Homo sapiens	109-113
9092833-1	1997	To elucidate the minimum requirement of amino acid residues for the active center in human adenylate kinase (hAK1), we carried out random site-directed mutagenesis of key lysine residues (K9, K21, K27, K31, K63, K131, and K194), which were conserved in mammalian AK1 species, with the pMEX8-hAK1 plasmid [Ayabe, T., et al.	Lysine	171-177	adenylate kinase 1	Homo sapiens	110-113
9092833-16	1997	Hence, hydrophilic lysine residues in hAK1 would appear to be essential for substrate-enzyme interaction with the coordination of some arginine residues, reported previously [Kim, H. J., et al.	Lysine	19-25	adenylate kinase 1	Homo sapiens	38-42
9143230-11	1997	Poly-L-arginine (10(-6) M) and poly-L-lysine (10(-6) M) abolished endothelium-dependent relaxations in response to bradykinin (10(-10)-10(-6) M) or calcium ionophore A23187 (10(-9)-10(-6) M).	Lysine	31-44	kininogen 1	Canis lupus familiaris	115-125
9118961-9	1997	Conversely, a catalytically inactive mutant that carried a lysine to alanine substitution within the kinase domain, displayed dominant-negative features and protected cells from interferon-gamma-induced cell death.	Lysine	59-65	interferon gamma	Homo sapiens	178-194
9122211-3	1997	In this report, we systematically analyze four positions in this region (Lys-147, Cys-149, Lys-151, and Glu-152) that together have been shown previously to be important for yeast TFIIB"s function in vivo.	Lysine	73-76	general transcription factor IIB	Homo sapiens	180-185
9092710-1	1997	A synthetic twenty-one amino acid peptide (AcE4K) based on the amino acid sequence of the influenza HA2 fusion peptide was coupled to a distearoylglycerol lipid anchor by amidation of an N-terminal lysine side chain.	Lysine	198-204	keratin 32	Homo sapiens	100-103
9089338-6	1997	Further investigation of the structure-activity profile following modification of the substituted phenylurea moiety appended off the lysine revealed that moving certain substituents, e.g. nitro or acetyl, from the 2- or 3-position on the phenyl ring to the 4-position, a relatively minor and subtle structural modification within the tetrapeptide, resulted in loss of CCK-A receptor selectivity and development of a trend toward CCK-B selectivity.	Lysine	133-139	cholecystokinin B receptor	Homo sapiens	429-434
9122211-3	1997	In this report, we systematically analyze four positions in this region (Lys-147, Cys-149, Lys-151, and Glu-152) that together have been shown previously to be important for yeast TFIIB"s function in vivo.	Lysine	91-94	general transcription factor IIB	Homo sapiens	180-185
9038186-8	1997	Mapping, isolation, and Edman degradation of the ATP-protectable peptide from [3H]PLP-inactivated borohydride-reduced mevalonate kinase allow assignment of lysine 13, a residue invariant in known mevalonate kinase sequences, as the modification site.	Lysine	156-162	mevalonate kinase	Rattus norvegicus	118-135
9119020-3	1997	When mutant cDNAs were expressed in Chinese hamster ovary (CHO)-K1 cells, they failed to be processed at the mutated processing signal, suggesting that the Arg-Ser-Lys-Arg motifs of preproendothelin-1 are recognized by CHO-K1 furin-like convertase.	Lysine	164-167	endothelin 1	Homo sapiens	182-200
9066781-1	1997	Deoxyhypusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (elF-5A) precursor using spermidine as the substrate.	Lysine	51-57	deoxyhypusine synthase	Homo sapiens	0-22
9038186-0	1997	Identification and functional characterization of an active-site lysine in mevalonate kinase.	Lysine	65-71	mevalonate kinase	Rattus norvegicus	75-92
9038186-6	1997	Recombinant rat mevalonate kinase was inactivated by the lysine-specific reagent, pyridoxal phosphate (PLP).	Lysine	57-63	mevalonate kinase	Rattus norvegicus	16-33
9038186-8	1997	Mapping, isolation, and Edman degradation of the ATP-protectable peptide from [3H]PLP-inactivated borohydride-reduced mevalonate kinase allow assignment of lysine 13, a residue invariant in known mevalonate kinase sequences, as the modification site.	Lysine	156-162	mevalonate kinase	Rattus norvegicus	196-213
9047300-1	1997	A 19-amino acid residue peptide, Gly-Trp-Leu-Lys-Ile-Lys-Ala-Ala-Met-Arg-Trp-Gly-Phe-Phe-Val-Arg-Lys-Lys- Ala, corresponding to the basic amphiphilic alpha-helix (BAA) motif at the C-terminus of a recombinant tobacco calmodulin-binding protein, TCB60, was synthesized.	Lysine	53-56	calmodulin	Nicotiana tabacum	217-227
9047300-1	1997	A 19-amino acid residue peptide, Gly-Trp-Leu-Lys-Ile-Lys-Ala-Ala-Met-Arg-Trp-Gly-Phe-Phe-Val-Arg-Lys-Lys- Ala, corresponding to the basic amphiphilic alpha-helix (BAA) motif at the C-terminus of a recombinant tobacco calmodulin-binding protein, TCB60, was synthesized.	Lysine	53-56	calmodulin	Nicotiana tabacum	217-227
15810427-3	1997	The results indicated that the lysine residues in cytochrome C molecules combine with cystine slowly.	Lysine	31-37	cytochrome c, somatic	Homo sapiens	50-62
9032461-7	1997	To identify amino acid residues of hs-PLA2 that are involved in its unique substrate specificity, we mutated two residues, Glu-56 and Lys-69, which were shown to interact with the phospholipid head group in the X-ray-crystallographic structure of the hs-PLA2-transition-state-analogue complex.	Lysine	134-137	phospholipase A2 group IB	Homo sapiens	35-42
9032461-7	1997	To identify amino acid residues of hs-PLA2 that are involved in its unique substrate specificity, we mutated two residues, Glu-56 and Lys-69, which were shown to interact with the phospholipid head group in the X-ray-crystallographic structure of the hs-PLA2-transition-state-analogue complex.	Lysine	134-137	phospholipase A2 group IB	Homo sapiens	38-42
9032461-9	1997	Thus it appears that Lys-69 is at least partially involved in the PA specificity of hs-PLA2 and Glu-56 in the distinction between PE and PC.	Lysine	21-24	phospholipase A2 group IB	Homo sapiens	84-91
9157850-3	1997	The values of rate constants of the digestions of the most easily hydrolyzable bonds (those formed by the pairs of the basic amino acid residues) in proinsulin were found to be of the same order as those formed by the separate lysine residues (Lys7) and those formed by the four basic amino acid residues of the C-terminal cluster of melittin.	Lysine	227-233	insulin	Homo sapiens	149-159
9033392-0	1997	Contribution of lysine 60f to S1" specificity of thrombin.	Lysine	16-22	coagulation factor II, thrombin	Homo sapiens	49-57
9033392-2	1997	To test this proposal, we prepared a Lys--&gt;Ala (K60fA) mutant of recombinant thrombin and determined whether this mutation enhanced the reactivity of thrombin with a variant inhibitor [antithrombin (AT)-Denver] and a substrate (protein C) containing poorly recognized P1" Leu residues.	Lysine	37-40	coagulation factor II, thrombin	Homo sapiens	80-88
9007203-1	1997	We previously reported the antiviral capacity of human serum albumin (HSA), which was modified by the introduction of a single (Suc-HSA) or two carboxylic groups (Aco-HSA) per lysine residue, yielding strongly negatively charged polypeptides.	Lysine	176-182	albumin	Homo sapiens	55-68
9058277-9	1997	For all diets, Met, Lys, and Phe were the first three limiting essential amino acids for milk protein synthesis.	Lysine	20-23	Weaning weight-maternal milk	Bos taurus	89-93
8999939-6	1997	In comparing sequence alignments and molecular models for IL-2 and IL-15, it was noted that lysine residues resided in regions of IL-15 that may have selectively disrupted receptor subunit binding.	Lysine	92-98	interleukin 2	Homo sapiens	58-62
8999895-7	1997	Specific glutamines or lysines of involucrin were used to cross-link the different proteins, such as glutamines 495 and 496 to desmoplakin, glutamine 288 to keratins, and lysines 468, 485, and 508 and glutamines 465 and 489 for interchain involucrin cross-links.	Lysine	23-30	involucrin	Homo sapiens	34-44
8999895-7	1997	Specific glutamines or lysines of involucrin were used to cross-link the different proteins, such as glutamines 495 and 496 to desmoplakin, glutamine 288 to keratins, and lysines 468, 485, and 508 and glutamines 465 and 489 for interchain involucrin cross-links.	Lysine	171-178	involucrin	Homo sapiens	34-44
9024120-5	1997	The percent decrease in relaxation at 1 nmol/L of corticotropin-releasing factor was about 88% with deendothelization, 100% with N omega-nitro-L-arginine methyl ester, 76% with LY-83,583, and 100% with alpha-helical corticotropin-releasing factor 9-41.	Lysine	177-179	corticotropin releasing hormone	Rattus norvegicus	50-80
9584848-1	1997	The active site lysine residue, K256, involved in Schiff"s base linkage with pyridoxal-5"-phosphate (PLP) in sheep liver recombinant serine hydroxymethyltransferase (rSHMT) was changed to glutamine or arginine by site-directed mutagenesis.	Lysine	16-22	serine hydroxymethyltransferase 1	Rattus norvegicus	166-171
18475763-2	1997	Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found.	Lysine	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
9028697-2	1997	OBJECTIVE: To evaluate the efficacy of the insulin analog lispro (Lys B28, Pro B29) in severe insulin resistance caused by human insulin antibodies.	Lysine	66-69	insulin	Homo sapiens	43-50
9028697-2	1997	OBJECTIVE: To evaluate the efficacy of the insulin analog lispro (Lys B28, Pro B29) in severe insulin resistance caused by human insulin antibodies.	Lysine	66-69	insulin	Homo sapiens	94-101
9028697-2	1997	OBJECTIVE: To evaluate the efficacy of the insulin analog lispro (Lys B28, Pro B29) in severe insulin resistance caused by human insulin antibodies.	Lysine	66-69	insulin	Homo sapiens	94-101
9112755-8	1997	The adaptation of the CaM molecule for binding the peptide requires disruption of its central helical linker between residues Lys-75 and Glu-82.	Lysine	126-129	calmodulin 1	Homo sapiens	22-25
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Lysine	61-64	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Lysine	69-72	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Lysine	69-72	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9306430-6	1997	The results of this study therefore identify two lysines of the NBD A- and C-motifs that are critical for MRP-mediated multidrug resistance.	Lysine	49-56	ATP binding cassette subfamily C member 1	Homo sapiens	106-109
9044254-4	1997	We also demonstrate that the regulation of the GSH1 gene by H2O2 depends upon the presence of the amino acids glutamate, glutamine and lysine in the media.	Lysine	135-141	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	47-51
9092208-6	1996	One female patient had familial CJD with a glutamate--&gt;lysine mutation at codon 200 of the prion protein (PrP) gene PRNP.	Lysine	58-64	prion protein	Homo sapiens	109-112
9437709-5	1997	Python neurokinin A (His-Lys-Thr-Asp-Ser-Phe-Val-Gly- Leu-Met.NH2) is identical to human/chicken/alligator neurokinin A.	Lysine	25-28	tachykinin precursor 1	Homo sapiens	7-19
8987991-6	1996	In contrast, tryptic digestions at Lys-61 and -68 occurred at the same rate for yeast and alpha-actin filaments.	Lysine	35-38	actin	Saccharomyces cerevisiae S288C	96-101
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Lysine	141-144	integrin subunit beta 3	Homo sapiens	47-53
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Lysine	141-144	integrin subunit beta 3	Homo sapiens	150-156
8943303-1	1996	Tissue transglutaminase (TGase II) is a Ca2+- and thiol-dependent enzyme that catalyzes the post-translational modification of proteins via the formation of epsilon(gamma-glutamyl) lysine bonds.	Lysine	181-187	transglutaminase 2	Homo sapiens	0-23
8997495-6	1996	Detection of [14C]-lysine-SPI-6 and SPI-58 in the serum free culture medium from ovine chondrocytes cultured in alginate beads in the presence of [14C]-lysine indicated that these SPIs were chondrocyte biosynthetic products.	Lysine	19-25	chromogranin A	Bos taurus	26-29
8977462-9	1996	In summary, the results of our study indicate that apo(a) kringle IV types 7 and 8 are required for maximal efficiency of Lp(a) formation, likely by virtue of their ability to mediate lysine-dependent non-covalent interactions with apoB-100 that precede disulfide bond formation.	Lysine	184-190	apolipoprotein B	Homo sapiens	232-240
8952483-9	1996	The hamster lysyl-tRNA synthetase efficiently aminoacylates both mammalian and yeast tRNA(Lys), whereas the yeast enzyme aminoacylates mammalian tRNA(Lys) with a catalytic efficiency 20-fold lower, as compared to its cognate tRNA.	Lysine	90-93	lysine--tRNA ligase	Cricetulus griseus	12-33
8952483-9	1996	The hamster lysyl-tRNA synthetase efficiently aminoacylates both mammalian and yeast tRNA(Lys), whereas the yeast enzyme aminoacylates mammalian tRNA(Lys) with a catalytic efficiency 20-fold lower, as compared to its cognate tRNA.	Lysine	150-153	lysine--tRNA ligase	Cricetulus griseus	12-33
8922361-1	1996	Insulin lispro [Lys (B28), Pro (B29) human insulin] is a rapidly absorbed analog that has diminished tendency to self-associate.	Lysine	16-19	insulin	Homo sapiens	0-7
8922361-1	1996	Insulin lispro [Lys (B28), Pro (B29) human insulin] is a rapidly absorbed analog that has diminished tendency to self-associate.	Lysine	16-19	MIS18 kinetochore protein A	Homo sapiens	21-24
8945538-4	1996	The m21 (with Lys-13 replaced by Thr [Lys-13--&gt;Thr]) and m71 (Lys-13--&gt;Glu) variants are significantly less effective than recombinant histatin-5 in killing Candida albicans, suggesting that Lys-13 is critical for candidacidal activity.	Lysine	14-17	histatin 3	Homo sapiens	141-151
9068370-6	1996	The molar potencies (EC50) of BK, TK and close analogs were: BK = 4.5 +/- 0.5 nM (n = 6), Lys-BK = 6.5 +/- 0.7 nM (n = 3), TK = 38.8 +/- 6.6 nM (n = 8), Met-Lys-BK = 41.5 +/- 13.4 nM (n = 4), Des-Arg9-BK = 2093 +/- 626 nM (n = 4).	Lysine	90-93	kininogen 1	Homo sapiens	30-32
8945538-4	1996	The m21 (with Lys-13 replaced by Thr [Lys-13--&gt;Thr]) and m71 (Lys-13--&gt;Glu) variants are significantly less effective than recombinant histatin-5 in killing Candida albicans, suggesting that Lys-13 is critical for candidacidal activity.	Lysine	38-41	histatin 3	Homo sapiens	141-151
8945538-4	1996	The m21 (with Lys-13 replaced by Thr [Lys-13--&gt;Thr]) and m71 (Lys-13--&gt;Glu) variants are significantly less effective than recombinant histatin-5 in killing Candida albicans, suggesting that Lys-13 is critical for candidacidal activity.	Lysine	38-41	histatin 3	Homo sapiens	141-151
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Lysine	9-12	TNF receptor superfamily member 6b	Homo sapiens	4-7
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Lysine	9-12	histatin 3	Homo sapiens	104-114
8945538-10	1996	Collectively, the data suggest that in addition to the helical conformation, specific residues such as Lys-13 and Arg-22 in the sequence of histatin-5 are, indeed, important for candidacidal activity.	Lysine	103-106	histatin 3	Homo sapiens	140-150
8994386-2	1996	KELTAE represents the C-terminal hexapeptide of WE-14, and SREWEDS (residue 316 human CgA Lys/Arg substitution) represents the C-terminal heptapeptide of the Intervening Peptide, located between pancreastatin and WE-14.	Lysine	90-93	chromogranin A	Homo sapiens	86-89
8950190-9	1996	However, the Lys-62--&gt;Arg substitution decreased translational accuracy and caused antibiotic sensitivity both in nonsuppressor and in SUP44 haploids.	Lysine	13-16	ribosomal 40S subunit protein S2	Saccharomyces cerevisiae S288C	138-143
8946838-5	1996	We previously reported that Tat is a direct angiogenic factor and noted the Tat arginine- and lysine-rich sequence is similar to that of other potent angiogenic growth factors, such as vascular endothelial growth factor-A (VEGF-A).	Lysine	94-100	vascular endothelial growth factor A	Homo sapiens	223-229
8911353-4	1996	RESULTS: The SLC3A1 gene has been shown to code for a protein that, when expressed in Xenopus oocytes, confers on these cells the ability to transport cystine, arginine, lysine and ornithine.	Lysine	170-176	solute carrier family 3 (amino acid transporter heavy chain), member 1 L homeolog	Xenopus laevis	13-19
8970159-4	1996	On poly-L-lysine-coated dishes, cell surface NG2 is associated with radial processes extending from the cell periphery.	Lysine	3-16	chondroitin sulfate proteoglycan 4	Homo sapiens	45-48
8970159-5	1996	Spreading on fibronectin/poly-L-lysine mixtures, as well as on matrix components such as laminin, tenascin, and type VI collagen, produces cells with mosaic characteristics, i.e., NG2 is associated with both types of structures.	Lysine	25-38	chondroitin sulfate proteoglycan 4	Homo sapiens	180-183
8906836-6	1996	To test whether intracellular signal transduction occurs, an IFN-gamma variant was constructed with the carboxyl-terminal endoplasmic reticulum retention signal Lys-Asp-Glu-Leu (KDEL).	Lysine	161-164	interferon gamma	Mus musculus	61-70
8955878-1	1996	To elucidate lysine residues in the N-terminal domain of human cytosolic adenylate kinase (hAK1, EC 2.7.4.3), random site-directed mutagenesis of K9, K27, and K31 residues was performed, and six mutants were analyzed by steady-state kinetics.	Lysine	13-19	adenylate kinase 1	Homo sapiens	91-95
8922738-23	1996	In contrast, guanylate cyclase inhibition with either LY 83,583 (10 microM) or methylene blue (10 microM) blocked completely the desensitization of intact rings to vasopressin.	Lysine	54-56	arginine vasopressin	Rattus norvegicus	164-175
8887633-1	1996	Signal-induced degradation of I(kappa)B(alpha) via the ubiquitin-proteasome pathway requires phosphorylation on residues serine 32 and serine 36 followed by ubiquitination on lysines 21 and 22.	Lysine	175-182	NFKB inhibitor alpha	Homo sapiens	30-46
8920857-0	1996	Glu227--&gt;Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.	Lysine	12-15	major histocompatibility complex, class I, A	Homo sapiens	51-97
8887676-7	1996	Lysine residues in p50 that were protected from modification by DNA were also protected from modification by I(kappa)B(gamma) but not I(kappa)B(alpha).	Lysine	0-6	nuclear factor kappa B subunit 1	Homo sapiens	19-22
9048422-4	1996	The McAP precursor contains an amino Cys(St-Bu) and an internal Lys(Ser).	Lysine	64-67	bromodomain containing 4	Homo sapiens	4-8
8921841-10	1996	Re-Hst5 variants with either Glu or Lys/Arg substitutions demonstrated significantly lower candidacidal activity in both assays, while the variant with His mutated showed essentially no activity at physiological concentrations.	Lysine	36-39	histatin 3	Homo sapiens	3-7
8900171-2	1996	A dynamic molecular model of FGF-1 docked into a duplex of the FGF receptor ectodomain and a hexadecameric heparin chain suggests that the NYKKPKL sequence does not directly interact with heparin or the receptor, but rather the lysine-leucine residues within the sequence indirectly stabilize a major receptor-binding domain.	Lysine	228-234	fibroblast growth factor 1	Homo sapiens	29-34
8873615-10	1996	The interaction of vWF with heparin was significantly reduced by substitution of Lys residues 642-645, indicating that these residues may form part of a heparin-binding domain in the carboxy-terminal half of the Cys509-Cys695 loop.	Lysine	81-84	von Willebrand factor	Homo sapiens	19-22
8902274-6	1996	Sequencing of the 14C-labeled tryptic peptides indicated that the acetaminophen bound to lysine 103 of Q2, lysines 202, 209 or 210 and 354 of Q5 and lysines 233 or 239 of calreticulin.	Lysine	149-156	calreticulin	Mus musculus	171-183
8798697-7	1996	Another mutation, with the adjacent lysine (Lys209) changed to Leu209-ATX, possesses normal motility stimulation with sustained phosphodiesterase activity but exhibits no detectable phosphorylation.	Lysine	36-42	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	70-73
8879195-6	1996	Analysis of the cDNA and genomic DNA of this patient showed that the patient is a compound heterozygote for a triplet nucleotide deletion in the p67-phox gene, predicting an in-frame deletion of lysine 58 in the p67-phox protein and a larger deletion of 11-13 kb in the other allele.	Lysine	195-201	CD33 molecule	Homo sapiens	145-148
9254513-3	1996	The increased proteolysis of lysine-rich histones (H1, H2A, H2B) was shown in swimming rats previously stimulated by prodigiosan.	Lysine	29-35	histone cluster 3, H2a	Rattus norvegicus	55-63
8957067-1	1996	We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native TNF-alpha.	Lysine	128-134	tumor necrosis factor	Homo sapiens	52-79
8957067-1	1996	We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native TNF-alpha.	Lysine	128-134	tumor necrosis factor	Homo sapiens	86-95
8957067-1	1996	We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native TNF-alpha.	Lysine	128-134	tumor necrosis factor	Homo sapiens	118-127
8957067-1	1996	We previously reported that the optimally PEGylated tumor necrosis factor-alpha (MPEG-TNF-alpha), in which 56% of the TNF-alpha-lysine amino groups were coupled with polyethylene glycol (PEG), had about 100-fold greater anti-tumor effect than native TNF-alpha.	Lysine	128-134	tumor necrosis factor	Homo sapiens	118-127
8823308-2	1996	We have investigated a family with partial AIS affecting three generations and have identified a G to A substitution in the AR gene at the fourth position 3" from the A of the ATG initiation codon changing the second amino acid residue from glutamic acid to lysine (EK2).	Lysine	258-264	androgen receptor	Homo sapiens	124-126
8798661-2	1996	We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mechanism.	Lysine	59-62	protein kinase C alpha	Homo sapiens	145-148
8787749-4	1996	Here we report experiments that show that the MSL proteins first associate with the male X chromosome as early as blastoderm stage, slightly earlier than the histone H4 isoform acetylated at lysine 16 is detected on the X chromosome.	Lysine	191-197	male-specific lethal 1	Drosophila melanogaster	46-49
8790154-0	1996	Fibrinogen Matsumoto II: gamma 308 Asn--&gt;Lys (AAT--&gt;AAG) mutation associated with bleeding tendency.	Lysine	44-47	serpin family A member 1	Homo sapiens	49-52
8790154-4	1996	Fibrinogen gamma-chain gene of the propositus was heterozygous for a missense mutation that resulted in Asn--&gt;Lys substitution at codon 308.	Lysine	113-116	fibrinogen gamma chain	Homo sapiens	0-22
21143275-4	1996	Asp(281) and Lys(199) of the rat AT(1) receptor ion-pair with Arg(2) and the Phe(3) alpha-COOH of angiotensin II (AngII), respectively, and the Asp(281) /Arg(2) interaction is critical for full agonist activity.	Lysine	13-16	angiotensinogen	Rattus norvegicus	98-112
21143275-6	1996	Agonist activity of AngII also requires an interaction of the Phe(2) side chain with His(256), which is achieved by docking of the alpha-COOH with Lys(199).	Lysine	147-150	angiotensinogen	Rattus norvegicus	20-25
8822928-2	1996	Upon activation by thrombin, activated TAFI (TAFIa) attenuates fibrinolysis, presumably by catalyzing the removal of C-terminal lysines from partially degraded fibrin.	Lysine	128-135	coagulation factor II, thrombin	Homo sapiens	19-27
8790354-6	1996	We propose that one site, containing residues Arg-150 and Lys-152, binds initially to EPO receptor on the cell surface.	Lysine	58-61	erythropoietin	Homo sapiens	86-89
8933727-8	1996	Treatment of crosslinked RNase A and its His, Lys and Lys-His derivatives for 5 min at 97 degrees C in a dithiothreitol-sodium dodecyl sulfate mixture efficiently ruptured a major part of the photodynamically formed crosslinks; treatment with the detergent alone had no effect.	Lysine	46-49	ribonuclease pancreatic	Bos taurus	25-32
8899531-5	1996	Milk fat yield was affected quadratically because it was greater when 0 or 150% of the deficiency of Met and Lys was supplied.	Lysine	109-112	Weaning weight-maternal milk	Bos taurus	0-4
8899531-6	1996	Percentages of CP and casein N in milk increased linearly as cows were fed increasing amounts of ruminally protected Met and Lys.	Lysine	125-128	Weaning weight-maternal milk	Bos taurus	34-38
8819479-2	1996	MPEG-TNF-alpha, especially, in which 56% of the lysine amino groups of TNF-alpha are coupled with PEG, exhibits 100-fold more antitumor activity in vivo than native TNF-alpha in the Meth-A murine sarcoma model.	Lysine	48-54	tumor necrosis factor	Mus musculus	5-14
8819479-2	1996	MPEG-TNF-alpha, especially, in which 56% of the lysine amino groups of TNF-alpha are coupled with PEG, exhibits 100-fold more antitumor activity in vivo than native TNF-alpha in the Meth-A murine sarcoma model.	Lysine	48-54	tumor necrosis factor	Mus musculus	71-80
8819479-2	1996	MPEG-TNF-alpha, especially, in which 56% of the lysine amino groups of TNF-alpha are coupled with PEG, exhibits 100-fold more antitumor activity in vivo than native TNF-alpha in the Meth-A murine sarcoma model.	Lysine	48-54	tumor necrosis factor	Mus musculus	71-80
8769411-7	1996	The critical nature of the fourth residue from the COOH terminus of the catalase PTS (lysine) is emphasized by the fact that substitution of this residue with a variety of other amino acids abolished or reduced peroxisomal targeting.	Lysine	86-92	catalase	Homo sapiens	72-80
8702589-7	1996	Recombinant human PGHS-2 with Val509 mutated to either Ile (the corresponding residue in PGHS-1), Ala, Glu, or Lys was expressed by transient transfection of COS-1 cells to evaluate the effects of the mutations on cyclooxygenase activity and on inhibition by four agents reported to be selective for PGHS-2 (NS398, nimesulide, DuP697, and SC58125).	Lysine	111-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-24
8883274-8	1996	In the variant gamma 337 Asn--&gt;Lys, the thrombin time was abnormally prolonged at 0.01 mM Ca2+, but it was normalized at 1 mM calcium.	Lysine	34-37	coagulation factor II, thrombin	Homo sapiens	43-51
8702612-0	1996	Identification of the alpha chain lysine donor sites involved in factor XIIIa fibrin cross-linking.	Lysine	34-40	coagulation factor XIII A chain	Homo sapiens	65-77
8702612-1	1996	Biochemical studies of fibrin cross-linking were conducted to identify the specific Aalpha chain lysine residues that potentially serve as Factor XIIIa amine donor substrates during alpha polymer formation.	Lysine	97-103	coagulation factor XIII A chain	Homo sapiens	139-151
8702612-2	1996	A previously characterized Factor XIIIa fibrin lysine labeling system was employed to localize sites of donor activity based on their covalent incorporation of a synthetic peptide acceptor substrate analog modelled after the NH2-terminal cross-linking domain of alpha2 antiplasmin.	Lysine	47-53	coagulation factor XIII A chain	Homo sapiens	27-39
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Lysine	367-373	catalase	Homo sapiens	197-205
8663495-2	1996	We previously reported that the amino acid sequence of leukocyte defensins resembles the lysine-binding site in the kringles of plasminogen and that defensin inhibits fibrinolysis mediated by tissue-type plasminogen activator (tPA) and plasminogen.	Lysine	89-95	plasminogen activator, tissue type	Homo sapiens	227-230
8889808-0	1996	Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analyses.	Lysine	35-38	carbonyl reductase 2	Mus musculus	63-86
8863157-6	1996	In the PAX3 gene, variation was detected at several sites including a Thr/Lys amino acid substitution in exon 6.	Lysine	74-77	paired box 3	Homo sapiens	7-11
8877726-7	1996	Furthermore, some IL-6 variants with lysine 54 replacements could be used to construct muteins that retained receptor binding but failed to activate gp130.	Lysine	37-43	interleukin 6	Homo sapiens	18-22
8844858-1	1996	An intricate architecture of covalent bonds and noncovalent interactions appear to position the side chain of Lys 41 properly within the active site of bovine pancreatic ribonuclease A (RNase A).	Lysine	110-113	ribonuclease pancreatic	Bos taurus	170-184
8844858-1	1996	An intricate architecture of covalent bonds and noncovalent interactions appear to position the side chain of Lys 41 properly within the active site of bovine pancreatic ribonuclease A (RNase A).	Lysine	110-113	ribonuclease pancreatic	Bos taurus	186-193
8663445-4	1996	We have studied the role of Lys-54 and Thr-55 in MgATP binding in the 6-phosphofructo-2-kinase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by site-directed mutagenesis.	Lysine	28-31	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	115-167
8767485-10	1996	The Arg/Lys sequence at position 25-30, which resembles the binding site of apoE, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor efficiently.	Lysine	8-11	apolipoprotein E	Rattus norvegicus	76-80
8924627-1	1996	The topography of the binding site of a monoclonal anti-substance P antibody directed toward the C-terminal pentapeptide of substance P, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, was analyzed further using a wide range of constrained analogues of substance P.	Lysine	145-148	tachykinin precursor 1	Homo sapiens	56-67
8924627-1	1996	The topography of the binding site of a monoclonal anti-substance P antibody directed toward the C-terminal pentapeptide of substance P, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, was analyzed further using a wide range of constrained analogues of substance P.	Lysine	145-148	tachykinin precursor 1	Homo sapiens	124-135
8924627-1	1996	The topography of the binding site of a monoclonal anti-substance P antibody directed toward the C-terminal pentapeptide of substance P, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, was analyzed further using a wide range of constrained analogues of substance P.	Lysine	145-148	tachykinin precursor 1	Homo sapiens	124-135
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Lysine	38-41	neurotensin	Homo sapiens	0-11
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Lysine	38-41	neurotensin	Homo sapiens	13-15
8755736-14	1996	On the basis of these and other data, we propose that the CHO cell MPSP that solubilizes ACE (1) only cleaves proteins embedded in a membrane; (2) requires an accessible stalk and cleaves at a minimum distance from both the membrane and proximal extracellular domain; (3) positions itself primarily with respect to the proximal extracellular domain; and (4) may have a weak preference for cleavage at Arg/Lys-X bonds.	Lysine	405-408	angiotensin-converting enzyme	Cricetulus griseus	89-92
8840095-0	1996	Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: using the rapid acting insulin analogue [Lys(B28), Pro(B29)] human insulin.	Lysine	120-123	insulin	Homo sapiens	102-109
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Lysine	65-68	insulin	Homo sapiens	31-38
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Lysine	65-68	insulin	Homo sapiens	48-55
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Lysine	65-68	insulin	Homo sapiens	48-55
8840095-1	1996	The time-action profile of the insulin analogue insulin lispro ([Lys(B28), Pro(B29)] human insulin) with its rapid onset and short duration of action might be more suitable to limit hyperglycaemic excursions after a meal rich in rapidly absorbable carbohydrates in comparison to regular human insulin.	Lysine	65-68	insulin	Homo sapiens	48-55
8683586-0	1996	Measurement and modelling of sequence-specific pKa values of lysine residues in calbindin D9k.	Lysine	61-67	S100 calcium binding protein G	Homo sapiens	80-93
8649776-2	1996	By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S.	Lysine	191-194	tumor protein p53	Homo sapiens	116-119
8662686-2	1996	Competition experiments with methylamine-treated alpha2-macroglobulin for binding to the multifunctional alpha2-macroglobulin receptor identify two Lys residues (residues 1370 and 1374 in human alpha2-macroglobulin) spaced by three amino acid residues as crucial for receptor binding.	Lysine	148-151	LDL receptor related protein 1	Homo sapiens	105-134
8675013-5	1996	This lysine residue is highly conserved in the zinc-binding region (ZBR) of the intracellular receptor (IR) superfamily; when it was mutated in MR and RARbeta, the resulting receptors similarly activated transcription at response elements that their wild-type counterparts repressed or were inactive.	Lysine	5-11	retinoic acid receptor, beta	Rattus norvegicus	151-158
8662595-4	1996	The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.	Lysine	101-104	LIF receptor subunit alpha	Homo sapiens	73-79
8643504-11	1996	In summary, our data support the idea that PC2 cleaves the 7B2 CT peptide at its internal Lys-Lys site within secretory granules; deactivation of the cleavage product is then accomplished by CPE, thus providing an efficient mechanism for intracellular inactivation of the CT peptide.	Lysine	90-93	proprotein convertase subtilisin/kexin type 2	Mus musculus	43-46
8643504-11	1996	In summary, our data support the idea that PC2 cleaves the 7B2 CT peptide at its internal Lys-Lys site within secretory granules; deactivation of the cleavage product is then accomplished by CPE, thus providing an efficient mechanism for intracellular inactivation of the CT peptide.	Lysine	94-97	proprotein convertase subtilisin/kexin type 2	Mus musculus	43-46
8639522-3	1996	We have used biochemical and structural methods to investigate the function of this lysine (K52) in phosphoryl transfer reactions catalyzed by the MAP kinase ERK2.	Lysine	84-90	mitogen-activated protein kinase 1	Homo sapiens	158-162
8735629-17	1996	Compared to the rabbit B1 receptor, the human B1 receptor shows low sensitivity to peptides that lack the N-terminal Lys.	Lysine	117-120	bradykinin receptor B1	Homo sapiens	46-57
8619628-1	1996	We showed that filaggrin linker segment peptide (FLSP) is a glutamine-rich substrate of epidermal transglutaminase (TGase), conjugating enzymatically with a phosphorylated cystatin alpha (P-cystatin alpha) which is a lysine-rich substrate of the enzyme.	Lysine	217-223	filaggrin	Rattus norvegicus	15-24
8661009-7	1996	Another unexpected finding is that the deduced amino acid sequences of PON2 in human, mouse, dog, turkey, and chicken and of human PON3 are all missing the amino acid residue 105, which is lysine in human PON1.	Lysine	189-195	paraoxonase 1	Homo sapiens	205-209
8612813-1	1996	Deoxyhypusine synthase catalyzes the first of two steps in the biosynthesis of hypusine, a modification of a specific lysine residue in the precursor of eukaryotic translation initiation factor 5A.	Lysine	118-124	deoxyhypusine synthase	Saccharomyces cerevisiae S288C	0-22
8796271-0	1996	Met-Lys-bradykinin-Ser, the kinin released from human kininogen by human pepsin.	Lysine	4-7	kininogen 1	Homo sapiens	8-18
8673107-3	1996	Sequencing of the loricrin gene revealed an insertion that shifts the translation frame of the C-terminal Gly- and Gln/Lys-rich domains, and is likely to impair cornification.	Lysine	119-122	loricrin cornified envelope precursor protein	Homo sapiens	18-26
8613982-11	1996	Modeling studies show that the covalently bound kringle 2 domain in full-length t-PA could interact with an extended hydrophobic groove in the catalytic domain; in such a docking geometry its "lysine binding site" and the "fibrin binding patch" of the catalytic domain are in close proximity.	Lysine	193-199	plasminogen activator, tissue type	Homo sapiens	80-84
8804580-0	1996	The functional involvement of Lys-38 in the heavy subunit of rat kidney gamma-glutamylcysteine synthetase: chemical modification and mutagenesis studies.	Lysine	30-33	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	72-105
8615810-1	1996	Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor by transferring an aminobutyl moiety from spermidine to the epsilon-amino group of a unique lysine residue.	Lysine	259-265	deoxyhypusine synthase	Homo sapiens	0-22
8669984-7	1996	Interestingly, the aromatic side chains of the CCK-B antagonist Boc-Trp-Phg-Asp-(1-Nal)-N(Me)2 in its preferential conformation, overlap their corresponding moieties in the two non peptide CCK-B antagonists L-362,260 and LY-288,513.	Lysine	221-223	cholecystokinin B receptor	Homo sapiens	47-52
8804580-4	1996	Chromatographic analysis on the tryptic hydrolyzates of trinitrophenylated (TNP) derivatives showed that Lys-38 in the gamma GCS heavy subunit was significantly modified in the presence of Mg2+.	Lysine	105-108	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	119-128
8804580-6	1996	These results suggest that the positively charged Lys-38 may be involved in the binding of glutamate to gamma GCS.	Lysine	50-53	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	104-113
8657102-10	1996	As substitution of a conserved lysine residue slows down the ubiquitination and degradation of IkappaBalpha without affecting its phosphorylation, polyubiquitination is required for inducible IkappaB degradation.	Lysine	31-37	NFKB inhibitor alpha	Homo sapiens	95-107
8636149-7	1996	In contrast, CHO cells expressing an insulin receptor mutated at the ATP binding site (Lys-1030 --&gt; Arg) showed no insulin-stimulated autophosphorylation or phosphorylation of IRS-1.	Lysine	87-90	insulin	Cricetulus griseus	37-44
8615021-2	1996	In view of this, we have designed and synthesized a construction referred to as "template assembled synthetic peptide" (TASP), in which a lysine-rich short polypeptide was used as a template to covalently anchor arrays of tripeptides, such as RPR, RPK, or KPR.	Lysine	138-144	pyruvate kinase L/R	Homo sapiens	248-251
8830326-1	1996	A variant human epidermal growth factor (EGF) receptor (HER) with a transition (G to A) at codon 497, resulting in a substitution of a lysine for an arginine, was recently demonstrated in several human pancreatic cancer cell lines.	Lysine	135-141	epidermal growth factor receptor	Homo sapiens	16-54
8630665-10	1996	Our results also show that the binding of kringle IV-10 to PM- fibrinogen is more complex than that to Lys, in that the former requires an additional binding site or sites outside the Lys-binding site.	Lysine	184-187	fibrinogen beta chain	Homo sapiens	63-73
8626444-7	1996	Specific amino acid residues critical for CaM binding by eNOS are also identified in this study as Phe-498, Lys-499, and Leu-511 in the bovine eNOS sequence.	Lysine	108-111	nitric oxide synthase 3	Bos taurus	57-61
8626444-7	1996	Specific amino acid residues critical for CaM binding by eNOS are also identified in this study as Phe-498, Lys-499, and Leu-511 in the bovine eNOS sequence.	Lysine	108-111	nitric oxide synthase 3	Bos taurus	143-147
8621379-5	1996	The mitogenic effect was specific for the NLS of FGF-1 because a peptide with double point mutations at lysine residues was inactive in stimulating DNA synthesis.	Lysine	104-110	fibroblast growth factor 1	Mus musculus	49-54
8599213-5	1996	Mutation of lysine residues within the C-terminus of p53 resulted in resistance to E6-mediated degradation in vitro, although the ability of the two proteins to form a complex was not affected.	Lysine	12-18	tumor protein p53	Homo sapiens	53-56
8799278-0	1996	Primary sequence and glycation at lysine-548 of bovine serum albumin.	Lysine	34-40	albumin	Homo sapiens	55-68
8728315-7	1996	The low affinity binding component present in both fibroblasts and HepG2 cells likely corresponds to the plasminogen receptor, as binding of r-apo[a] to these sites was specifically decreased by the addition of plasminogen or the lysine analogue epsilon-aminocaproic acid, but not by the addition of tissue-type plasminogen activator.	Lysine	230-236	plasminogen activator, tissue type	Homo sapiens	300-333
8652569-9	1996	These results suggest that apo(a) is maintained in a compact state through interactions between weak lysine binding sites and multiple lysines on apoB and/or apo(a), and that these interactions can be disrupted by 6-AHA, a lysine analog.	Lysine	135-142	apolipoprotein B	Homo sapiens	146-150
8626758-5	1996	YAP3p generated Met-enkephalin-Lys-Lys from amidorphin showing that cleavage by this enzyme can occur at a lone pair of Lys residues.	Lysine	31-34	Yap3p	Saccharomyces cerevisiae S288C	0-5
8626776-12	1996	Additionally, we present an extensive mutagenic analysis of P-selectin Lys-113, a residue that has previously been implicated in P-selectin binding to both sLeX and 3-sulfated galactosylceramide (sulfatide).	Lysine	71-74	selectin P	Rattus norvegicus	60-70
8626776-12	1996	Additionally, we present an extensive mutagenic analysis of P-selectin Lys-113, a residue that has previously been implicated in P-selectin binding to both sLeX and 3-sulfated galactosylceramide (sulfatide).	Lysine	71-74	selectin P	Rattus norvegicus	129-139
8652569-9	1996	These results suggest that apo(a) is maintained in a compact state through interactions between weak lysine binding sites and multiple lysines on apoB and/or apo(a), and that these interactions can be disrupted by 6-AHA, a lysine analog.	Lysine	135-141	apolipoprotein B	Homo sapiens	146-150
8577707-7	1996	After membrane insertion, TNF exhibits a trimeric configuration in which the carboxyl termini are no longer exposed; however, the proximal salt-bridged Lys-11 residues as well as regional surface amino acids (Glu-23, Arg-32, and Arg-44) are notably more accessible to proteases.	Lysine	152-155	tumor necrosis factor	Homo sapiens	26-29
8547351-4	1996	The incorporation of Carbobenzoxy-Gln-Gly into alpha-lactalbumin through the enzyme reaction was investigated to determine the amounts of lysine residues which are present at molecular surface and available to the enzyme.	Lysine	138-144	lactalbumin alpha	Homo sapiens	47-64
8576235-7	1996	Point mutants in which arginine 172 or lysine 184 of alpha-actinin were replaced by isoleucine reduced the inhibitory effect on PLC activity by nearly half.	Lysine	39-45	actinin, alpha 4	Gallus gallus	53-66
8619913-2	1996	Polyacrylamide gel electrophoresis and gel filtration showed that heat denaturation converted ovalbumin to high Mr polymers, whereas formaldehyde/lysine-treated ovalbumin remained monomeric with only a small proportion forming oligomers.	Lysine	146-152	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	161-170
8745400-2	1996	It is known that in TIM, three residues, Lys 13 (loop 1), His 95 (loop 4), and Glu 167 (loop 6) are the crucial catalytic residues.	Lysine	41-44	triosephosphate isomerase 1	Homo sapiens	20-23
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Lysine	104-110	vasoactive intestinal peptide	Rattus norvegicus	49-52
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Lysine	104-110	vasoactive intestinal peptide	Rattus norvegicus	171-174
8549832-1	1996	Deoxyhypusine synthase is essentially required for the post-translational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A, which appears to be pivotal for cell proliferation.	Lysine	126-132	deoxyhypusine synthase	Homo sapiens	0-22
8576261-4	1996	Recombinant human E2EPF catalyzed multiubiquitin chain formation exclusively through Lys-11 of ubiquitin while recombinant yeast RAD6 formed chains linked only through Lys-6.	Lysine	85-88	ubiquitin conjugating enzyme E2 S	Homo sapiens	18-23
8619815-4	1996	Immunoblotting analyses, using anti-hexitol lysine IgG, indicated that glycated Cu.Zn-SOD contains Amadori products.	Lysine	44-50	superoxide dismutase 1	Rattus norvegicus	80-89
8573586-0	1996	Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes.	Lysine	22-28	fatty acid binding protein 3	Homo sapiens	76-108
8573586-7	1996	To directly examine the role of charged lysine residues on the HFABP surface in specific interactions with membranes, chemical modification and selective mutagenesis of HFABP were used.	Lysine	40-46	fatty acid binding protein 3	Homo sapiens	63-68
8573586-8	1996	All surface lysine residues were neutralized by acetylation of recombinant HFABP with acetic anhydride.	Lysine	12-18	fatty acid binding protein 3	Homo sapiens	75-80
9010602-10	1996	Only one of these regions is polar and highly hydrated in unbound hemoprotein; 2) interactions of the polar regions of 2B4 and NCPR are necessary to bring CPM-labelled cysteine of NCPR in short distance of the heme of 2B4; and 3) some of the lysine residues located in the proximity of the polar binding regions are apparently involved in the formation of the internal salt bridges in the molecule of 2B4.	Lysine	242-248	cytochrome p450 oxidoreductase	Homo sapiens	127-131
8787920-2	1996	The nucleotide sequence of blaTEM-28 differed from that of blaTEM-1 by two base changes, resulting in amino acid substitutions of Arg-164 to His and Glu-240 to Lys.	Lysine	160-163	beta-lactamase	Escherichia coli	59-67
9010602-10	1996	Only one of these regions is polar and highly hydrated in unbound hemoprotein; 2) interactions of the polar regions of 2B4 and NCPR are necessary to bring CPM-labelled cysteine of NCPR in short distance of the heme of 2B4; and 3) some of the lysine residues located in the proximity of the polar binding regions are apparently involved in the formation of the internal salt bridges in the molecule of 2B4.	Lysine	242-248	cytochrome p450 oxidoreductase	Homo sapiens	180-184
8530448-0	1995	Urokinase-type plasminogen activator-induced monocyte adhesion requires a carboxyl-terminal lysine and cAMP-dependent signal transduction.	Lysine	92-98	plasminogen activator, urokinase	Homo sapiens	0-36
8530448-8	1995	Moreover, when a carboxyl-terminal lysine analog was added, the proadhesive effect of carboxypeptidase B-treated u-PA or ATF was restored.	Lysine	35-41	plasminogen activator, urokinase	Homo sapiens	113-117
12237715-1	1996	A synthetic gene of human tumor necrosis factor alpha (hTNF-alpha) was mutated by polymerase chain reaction using a multi-site mutated primer with the Arg-2 codon (CGT) replaced by a lysine codon (AAA).	Lysine	183-189	tumor necrosis factor	Homo sapiens	55-65
8530448-7	1995	When u-PA or ATF was treated with immobilized carboxypeptidase B, its proadhesive effect was abolished, implicating the involvement of carboxyl-terminal lysine residues (Lys158 on u-PA and Lys135 on ATF).	Lysine	153-159	plasminogen activator, urokinase	Homo sapiens	5-9
7499219-2	1995	Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner.	Lysine	64-70	angiotensinogen	Rattus norvegicus	0-6
8719938-2	1995	The authors studied the influence of TGF-beta 1 on the modification of lysine residues of collagen I.	Lysine	71-77	transforming growth factor beta 1	Homo sapiens	37-47
8869642-11	1995	Indeed, lysine analogue (epsilon-amino-caproic acid) sensitive binding of isolated t-PA kringle 2 domain to u-PA could be observed.	Lysine	8-14	plasminogen activator, tissue type	Homo sapiens	83-87
8869642-11	1995	Indeed, lysine analogue (epsilon-amino-caproic acid) sensitive binding of isolated t-PA kringle 2 domain to u-PA could be observed.	Lysine	8-14	plasminogen activator, urokinase	Homo sapiens	108-112
7479976-4	1995	Here we provide evidence that lysine residues 21 and 22 serve as the primary sites for signal-induced ubiquitination of I kappa B alpha.	Lysine	30-36	NFKB inhibitor alpha	Homo sapiens	120-135
7479976-5	1995	Conservative Lys--&gt;Arg substitutions at both Lys-21 and Lys-22 produce dominant-negative mutants of I kappa B alpha in vivo.	Lysine	13-16	NFKB inhibitor alpha	Homo sapiens	103-118
7479976-5	1995	Conservative Lys--&gt;Arg substitutions at both Lys-21 and Lys-22 produce dominant-negative mutants of I kappa B alpha in vivo.	Lysine	48-51	NFKB inhibitor alpha	Homo sapiens	103-118
7479976-5	1995	Conservative Lys--&gt;Arg substitutions at both Lys-21 and Lys-22 produce dominant-negative mutants of I kappa B alpha in vivo.	Lysine	48-51	NFKB inhibitor alpha	Homo sapiens	103-118
7479976-7	1995	Moreover, these Lys--&gt;Arg mutations prevent signal-dependent degradation of I kappa B alpha in vivo and ubiquitin conjugation in vitro.	Lysine	16-19	NFKB inhibitor alpha	Homo sapiens	79-94
7479976-8	1995	We conclude that site-specific ubiquitination of phosphorylated I kappa B alpha at Lys-21 and/or Lys-22 is an obligatory step in the activation of NF-kappa B.	Lysine	83-86	NFKB inhibitor alpha	Homo sapiens	64-79
7479976-8	1995	We conclude that site-specific ubiquitination of phosphorylated I kappa B alpha at Lys-21 and/or Lys-22 is an obligatory step in the activation of NF-kappa B.	Lysine	83-86	nuclear factor kappa B subunit 1	Homo sapiens	147-157
7479976-8	1995	We conclude that site-specific ubiquitination of phosphorylated I kappa B alpha at Lys-21 and/or Lys-22 is an obligatory step in the activation of NF-kappa B.	Lysine	97-100	nuclear factor kappa B subunit 1	Homo sapiens	147-157
8529662-4	1995	Sequence analysis showed that ERp57/GRP58 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals.	Lysine	70-73	protein disulfide isomerase family A member 3	Homo sapiens	30-35
8529662-4	1995	Sequence analysis showed that ERp57/GRP58 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals.	Lysine	70-73	protein disulfide isomerase family A member 3	Homo sapiens	36-41
7574712-4	1995	Sequencing of the radiolabeled tryptic peptide indicated that methoxychlor bound to cysteine 372 or 375 or to lysine 376 of 5"-ID1.	Lysine	110-116	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	127-130
8722069-1	1995	OBJECTIVE: To compare postprandial metabolic control after subcutaneous injection of a short-acting insulin analog [Lys(B289),Pro(B29)] (Lispro) or human regular insulin (Humulin R U-100 [Hum-R]) in insulin-dependent diabetes mellitus (IDDM) of short duration with residual beta-cell function.	Lysine	116-119	insulin	Homo sapiens	100-107
7573557-2	1995	A peptide with substance P-like immunoreactivity was isolated from an extract of bowfin stomach and its primary structure was established as Ser-Lys-Ser-His-Gln-Phe-Tyr-Gly-Leu-Met-NH2.	Lysine	145-148	tachykinin precursor 1	Homo sapiens	15-26
7567989-0	1995	Elongation factor 1 alpha concentration is highly correlated with the lysine content of maize endosperm.	Lysine	70-76	LOC541783	Zea mays	0-25
7583555-3	1995	In the first step, a loose complex is formed involving kringle-4 motifs in apo(a) and one or more Lys side chains in apoB-100.	Lysine	98-101	apolipoprotein B	Homo sapiens	117-125
7554377-11	1995	One serum with anti-MPO antibodies bound to Lys-C and Glu-C-digested MPO in dot blots.	Lysine	44-47	myeloperoxidase	Homo sapiens	20-23
7650066-3	1995	A seven residue peptide containing residues 368-374, Val Tyr Tyr Val Gly Arg Lys, was demonstrated to be capable of inducing chemotactic migration of human peripheral blood neutrophils, monocytes, monocyte leukemia cell line THP-1, and infant foreskin fibroblasts.	Lysine	77-80	GLI family zinc finger 2	Homo sapiens	225-230
7650691-3	1995	Incorporation of the Lys(Tac) side chain into 3 produced the novel agonist analog 7 (EC50 = 28 nM in the GPGB) with excellent affinity for both human CCK-A (IC50 = 12 nM) and CCK-B (IC50 = 17 nM) receptors.	Lysine	21-24	cholecystokinin B receptor	Homo sapiens	175-180
24169890-1	1995	The levels of certain essential amino acids, in particular cysteine, lysine and methionine, in the seed storage protein of a commercial spring variety of rape, Brassica napus, have been increased by the introduction of an antisense gene for cruciferin, which is the most abundant storage protein in rapeseed.	Lysine	69-75	cruciferin	Brassica napus	241-251
24169890-7	1995	Amino-acid analysis of the seed storage protein revealed that T1 seeds with reduced amounts of cruciferin contained higher relative levels of three essential amino acids, namely, lysine, methionine and cysteine, with increases of 10%, 8% and 32% over the respective levels in non-transgenic seeds (B. napus cv Westar).	Lysine	179-185	cruciferin	Brassica napus	95-105
7657661-0	1995	Role of glycine 1 and lysine 2 in the glycation of bovine gamma B-crystallin.	Lysine	22-28	crystallin gamma B	Bos taurus	58-76
7657661-5	1995	Glycation of gamma B-crystallin by [14C]glucose was reduced significantly due to the mutation of Lys-2, supporting the view that Lys-2 is a major glycation site.	Lysine	97-100	crystallin gamma B	Bos taurus	13-31
7657661-5	1995	Glycation of gamma B-crystallin by [14C]glucose was reduced significantly due to the mutation of Lys-2, supporting the view that Lys-2 is a major glycation site.	Lysine	129-132	crystallin gamma B	Bos taurus	13-31
7657661-9	1995	Glycation with DL-glyceraldehyde showed an important role for both Gly-1 and Lys-2 in the glycation-mediated gamma B-crystallin cross-linking.	Lysine	77-80	crystallin gamma B	Bos taurus	109-127
7667299-3	1995	Differential lysine-specific peptide mapping of unmodified and suicide-inactivated LTA4 hydrolase has been used to identify a henicosapeptide, encompassing the amino acid residues 365-385 of human LTA4 hydrolase, which is involved in the binding of LTA4, LTA4 methyl ester, and LTA4 ethyl ester to the native enzyme.	Lysine	13-19	leukotriene A4 hydrolase	Homo sapiens	83-97
7667299-3	1995	Differential lysine-specific peptide mapping of unmodified and suicide-inactivated LTA4 hydrolase has been used to identify a henicosapeptide, encompassing the amino acid residues 365-385 of human LTA4 hydrolase, which is involved in the binding of LTA4, LTA4 methyl ester, and LTA4 ethyl ester to the native enzyme.	Lysine	13-19	leukotriene A4 hydrolase	Homo sapiens	197-211
7667299-4	1995	A modified form of this peptide, generated by lysine-specific digestion of LTA4 hydrolase inactivated by LTA4 ethyl ester, could be isolated for complete Edman degradation.	Lysine	46-52	leukotriene A4 hydrolase	Homo sapiens	75-89
7629198-6	1995	This differing pH dependence of binding suggests that a lysine residue is involved in proteoglycan association with fibrillar A beta, whereas a protonated histidine appears to be needed for binding of the glycoconjugates to non-fibrillar peptide.	Lysine	56-62	amyloid beta precursor protein	Homo sapiens	126-132
7582980-0	1995	Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.	Lysine	75-81	coagulation factor II, thrombin	Homo sapiens	44-52
7627718-6	1995	Chemical modification of LDL apoB lysines or arginines markedly reduced the ability of the lipoprotein to block the binding of 125I-LDL to LPL-containing matrix, suggesting that apoB positively charged amino acids are involved in the interaction.	Lysine	34-41	apolipoprotein B	Homo sapiens	29-33
7627718-6	1995	Chemical modification of LDL apoB lysines or arginines markedly reduced the ability of the lipoprotein to block the binding of 125I-LDL to LPL-containing matrix, suggesting that apoB positively charged amino acids are involved in the interaction.	Lysine	34-41	apolipoprotein B	Homo sapiens	178-182
7581003-1	1995	Recombinant A17 Lys human insulin precursor expressed in yeast cells was isolated from the culture medium.	Lysine	16-19	insulin	Homo sapiens	26-33
7636189-1	1995	Crystallographic analysis of HLA-DR1 molecules reveals a "dimer of dimers" with two reciprocal salt bridges between Glu 88 and Lys 111 of the two DR alpha chains.	Lysine	127-130	solute carrier family 26 member 3	Homo sapiens	146-154
7641799-1	1995	The small cell lung carcinoma cell line U-1690 bound beta-endorphin via nonopioid binding sites also recognized by the C-terminal part of this opioid peptide Lys-Lys-Gly-Glu, but not by opiate alkaloids such as naloxone and morphine or other opioid peptides.	Lysine	158-161	proopiomelanocortin	Homo sapiens	53-67
7641799-1	1995	The small cell lung carcinoma cell line U-1690 bound beta-endorphin via nonopioid binding sites also recognized by the C-terminal part of this opioid peptide Lys-Lys-Gly-Glu, but not by opiate alkaloids such as naloxone and morphine or other opioid peptides.	Lysine	162-165	proopiomelanocortin	Homo sapiens	53-67
7635945-4	1995	DNA sequence analysis of the mutant apoE gene revealed a single-point mutation that resulted in the substitution of glutamic acid (GAG) for lysine (AAG) at residue 146 in the proposed receptor-binding domain of apoE.	Lysine	140-146	apolipoprotein E	Homo sapiens	36-40
7635945-4	1995	DNA sequence analysis of the mutant apoE gene revealed a single-point mutation that resulted in the substitution of glutamic acid (GAG) for lysine (AAG) at residue 146 in the proposed receptor-binding domain of apoE.	Lysine	140-146	apolipoprotein E	Homo sapiens	211-215
7631779-7	1995	In the presence of insulin, cellular ATP levels were significantly increased by L-Arg, L-Glu, and L-Lys as well.	Lysine	98-103	insulin	Homo sapiens	19-26
7624327-0	1995	A defective signal peptide in the maize high-lysine mutant floury 2.	Lysine	45-51	prolamin 22 kDa alpha zein z1C2	Zea mays	59-67
7624327-1	1995	The maize floury 2 (fl2) mutation enhances the lysine content of the grain, but the soft texture of the endosperm makes it unsuitable for commercial production.	Lysine	47-53	prolamin 22 kDa alpha zein z1C2	Zea mays	10-18
7624327-1	1995	The maize floury 2 (fl2) mutation enhances the lysine content of the grain, but the soft texture of the endosperm makes it unsuitable for commercial production.	Lysine	47-53	prolamin 22 kDa alpha zein z1C2	Zea mays	20-23
8591044-7	1995	In the structures with inhibitor bound, the catalytic lysine (Lys13 in loop-1) and the catalytic histidine (His95 in loop-4) adopt conformations similar to those observed in wild-type TIM, but very different from the monoTIM structure.	Lysine	54-60	triosephosphate isomerase 1	Homo sapiens	184-187
7622471-6	1995	The C-terminal peptide contains only two basic residues, a Lys and an Arg (assumed to be analogous to Lys68 and Arg74 of hC5a), which could act as counter-ions for Glu199 of the receptor.	Lysine	59-62	complement C5a receptor 1	Homo sapiens	121-125
7622471-9	1995	Furthermore, the equivalent C-terminal peptide to hC5a des-Arg74 (i.e. lacking the C-terminal Arg) could partially activate the wild type but not the mutant receptor, whereas the converse peptide, containing Arg but containing Met instead of Lys, had equal potencies for both wild type and mutant receptors.	Lysine	242-245	complement C5a receptor 1	Homo sapiens	50-54
7793988-9	1995	A significant decrease in binding of EC-derived perlecan to A beta (1-28) was observed when a sequence within the putative heparin-binding motif of A beta (His13His14Gln15Lys16) was replaced by the uncharged peptide sequence, Gly13Gly14Gln15Gly16, indicating a perlecan binding site on A beta near the postulated alpha-secretase site (at Lys-16).	Lysine	171-174	amyloid beta precursor protein	Homo sapiens	60-66
8537329-1	1995	Maturation of human Protein C (HPC) precursor to a zymogen in the liver requires endoproteolytic cleavages after a basic dipeptide, Lys-2-Arg-1 in the propeptide and Lys156-Arg157 connecting the light and heavy chain.	Lysine	132-135	arginase 1	Sus scrofa	138-143
8537329-6	1995	Since rHPC was found to be stable both in milk and after purification, it is possible that these new cleavages on the amino side of arginine at dipeptide sites Lys-2-Arg-1, Lys151-Arg152, and Lys156-Arg157 could have occurred in the mammary gland.	Lysine	160-163	arginase 1	Sus scrofa	166-171
7554236-2	1995	However, recent studies indicate that the extent of inhibition is minimized when cells were cultured on poly-L-lysine-coated or laminin-coated versus uncoated plates, suggesting that the role of GAP-43 in neuritogenesis may be specifically related to membrane adhesiveness.	Lysine	104-117	growth associated protein 43	Mus musculus	195-201
7598715-7	1995	Differently than estrogen, LY 139478 at high dose significantly reduced IL-6 release by these cells.	Lysine	27-29	interleukin 6	Homo sapiens	72-76
7793988-9	1995	A significant decrease in binding of EC-derived perlecan to A beta (1-28) was observed when a sequence within the putative heparin-binding motif of A beta (His13His14Gln15Lys16) was replaced by the uncharged peptide sequence, Gly13Gly14Gln15Gly16, indicating a perlecan binding site on A beta near the postulated alpha-secretase site (at Lys-16).	Lysine	171-174	amyloid beta precursor protein	Homo sapiens	148-154
7793988-9	1995	A significant decrease in binding of EC-derived perlecan to A beta (1-28) was observed when a sequence within the putative heparin-binding motif of A beta (His13His14Gln15Lys16) was replaced by the uncharged peptide sequence, Gly13Gly14Gln15Gly16, indicating a perlecan binding site on A beta near the postulated alpha-secretase site (at Lys-16).	Lysine	171-174	amyloid beta precursor protein	Homo sapiens	148-154
7539426-8	1995	Mutations at Glu-596 and Lys-599 decreased binding of VWF to GPIb without affecting its binding to botrocetin, suggesting that this segment interacts directly with GPIb.	Lysine	25-28	von Willebrand factor	Homo sapiens	54-57
7760048-4	1995	Recent studies by two different laboratories have demonstrated the presence of a cdc2-like kinase [cyclin-dependent kinase-5 (cdk5)] in nervous tissue that selectively phosphorylates KSPXKX and XS/TXK motifs in NF-H and lysine-rich histone (H1).	Lysine	220-226	TXK tyrosine kinase	Rattus norvegicus	197-200
7796890-6	1995	Inhibition of plasminogen activation occurred with plasminogen activator inhibitor-1, anti-catalytic anti-tissue-plasminogen activator antibody, epsilon-aminocaproic acid, which inhibits the binding of plasminogen through its lysine binding sites, and amiloride, which specifically inhibits urokinase.	Lysine	226-232	serpin family E member 1	Rattus norvegicus	51-84
7626508-6	1995	The introduction of amino-acid substitutions between Lys-134 and Phe-148 of SHBG has also indicated that residues including and immediately N-terminal of Met-139 may influence steroid-binding specificity, while those immediately C-terminal of Met-139 represent at least a part of the dimerization domain.	Lysine	53-56	sex hormone binding globulin	Homo sapiens	76-80
7718556-1	1995	Addition of the Lys(-2)-Arg(-1) dipeptide, present in the precursor protein, to the N-terminus of endothelin-1 (ET-1), to form a 23-residue peptide (KR-ET-1) has been shown to greatly improve formation of native disulfide bridges and to dramatically decrease biological activity.	Lysine	16-19	endothelin 1	Homo sapiens	98-110
7603451-1	1995	A polyclonal antibody to the human adenosine A2b receptor (A2bR) was produced by immunizing a chicken with a multiple antigenic peptide consisting of eight copies of a 16-amino acid peptide, corresponding to the presumed second extracellular loop of the A2bR, linked to a branched lysine core.	Lysine	281-287	adenosine A2b receptor	Homo sapiens	35-57
7734321-2	1995	Natural human TNF-alpha was chemically conjugated with monomethoxy polyethylene glycol (PEG) using succinimidyl coupling of lysine amino groups of TNF-alpha.	Lysine	124-130	tumor necrosis factor	Homo sapiens	14-23
7734321-2	1995	Natural human TNF-alpha was chemically conjugated with monomethoxy polyethylene glycol (PEG) using succinimidyl coupling of lysine amino groups of TNF-alpha.	Lysine	124-130	tumor necrosis factor	Homo sapiens	147-156
7641075-0	1995	Role of lysine residues in the nucleotides binding to bovine liver high-Km aldehyde reductase.	Lysine	8-14	aldo-keto reductase family 1 member B1	Bos taurus	75-93
7658163-2	1995	When PLA2 from the venom of Agkistrodon piscivorus piscivorus was pretreated with 4-nitro-3-octanoyl-oxybenzoic acid to acylate epsilon-amino groups of two lysines (Lys-7 and Lys-10) and the resulting acylated enzyme was covalently coupled onto carbonyldiimidazole-activated cross-linked agarose beads, the immobilized acylated enzyme showed high retention of activity toward various aggregated phospholipids.	Lysine	156-163	phospholipase A2 group IB	Homo sapiens	5-9
7721771-0	1995	Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA"s lysine binding site.	Lysine	108-114	plasminogen activator, tissue type	Homo sapiens	0-33
7721771-0	1995	Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA"s lysine binding site.	Lysine	108-114	plasminogen activator, tissue type	Homo sapiens	35-38
7721771-0	1995	Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA"s lysine binding site.	Lysine	108-114	plasminogen activator, urokinase	Homo sapiens	55-91
7721771-0	1995	Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA"s lysine binding site.	Lysine	108-114	plasminogen activator, urokinase	Homo sapiens	93-96
7721731-1	1995	alpha 1-Antitrypsin plasma deficiency variants which form hepatic inclusion bodies within the endoplasmic pathway include the common Z variant (Glu342--&gt;Lys) and the rarer alpha 1-antitrypsin Siiyama (Ser53--&gt;Phe).	Lysine	156-159	serpin family A member 1	Homo sapiens	0-19
7734321-6	1995	PEG-TNF-alpha s, in which 29% and 56% of lysine residues were coupled to PEG, had anti-tumour activity approximately 4 and 100 times greater than unmodified TNF-alpha in the murine Meth-A fibrosarcoma model.	Lysine	41-47	tumor necrosis factor	Homo sapiens	4-13
7612412-13	1995	Seronegative (prognostically good) and seropositive (prognostically worse) patients can be distinguished by the arginine versus lysine substitution at position 71 of the HLA-DRB1 gene.	Lysine	128-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	170-178
7721771-0	1995	Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA"s lysine binding site.	Lysine	108-114	plasminogen activator, tissue type	Homo sapiens	102-105
7721771-5	1995	We found that occupation of the lysine binding site of tPA by a lysine or arginine side chain from the urokinase moiety is responsible for the high temperature transition as well as for the failure of the chimeras to exhibit the expected fibrin binding properties.	Lysine	32-38	plasminogen activator, tissue type	Homo sapiens	55-58
7721771-5	1995	We found that occupation of the lysine binding site of tPA by a lysine or arginine side chain from the urokinase moiety is responsible for the high temperature transition as well as for the failure of the chimeras to exhibit the expected fibrin binding properties.	Lysine	64-70	plasminogen activator, tissue type	Homo sapiens	55-58
7721771-7	1995	This intermolecular interaction was strongly inhibited by epsilon-aminocaproic acid indicating that the lysine binding site of tPA is involved.	Lysine	104-110	plasminogen activator, tissue type	Homo sapiens	127-130
7718556-1	1995	Addition of the Lys(-2)-Arg(-1) dipeptide, present in the precursor protein, to the N-terminus of endothelin-1 (ET-1), to form a 23-residue peptide (KR-ET-1) has been shown to greatly improve formation of native disulfide bridges and to dramatically decrease biological activity.	Lysine	16-19	endothelin 1	Homo sapiens	112-116
7893672-0	1995	Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.	Lysine	87-93	coagulation factor II, thrombin	Homo sapiens	40-48
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Lysine	132-135	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Lysine	132-135	proprotein convertase subtilisin/kexin type 2	Bos taurus	10-13
7613467-7	1995	The catalytic activities of the recombinant proteins were analyzed with chromogenic substrates containing lysine in the P1, P2, or P3 positions.	Lysine	106-112	exosome component 10	Homo sapiens	120-133
7873546-2	1995	To explore the heparin-binding site of the inhibitor, we have modified the lysine and arginine residues of MPI and its isolated C-terminal domain by using 4-N,N-(dimethylamino)azobenzene-4"-isothiocyano-2"-sulfonic acid (S-DABITC) [Chang, J. Y.	Lysine	75-81	secretory leukocyte peptidase inhibitor	Homo sapiens	107-110
7890036-3	1995	In the present study, we labeled the Lys residues of apo AI with 13C by reductive methylation and used 13C NMR to confirm the formation of a native-like structure of apo AI in this environment.	Lysine	37-40	apolipoprotein A1	Homo sapiens	53-59
7890036-3	1995	In the present study, we labeled the Lys residues of apo AI with 13C by reductive methylation and used 13C NMR to confirm the formation of a native-like structure of apo AI in this environment.	Lysine	37-40	apolipoprotein A1	Homo sapiens	166-172
7749849-2	1995	Glucose was incorporated into Lp(a) in proportions that mirrored the distribution of lysines between apolipoprotein (apo) B-100 and apo(a).	Lysine	85-92	apolipoprotein B	Homo sapiens	101-127
7873546-10	1995	Modification of a limited number of lysine and arginine residues in full-length MPI led to a 6-fold decrease in affinity for heparin.	Lysine	36-42	secretory leukocyte peptidase inhibitor	Homo sapiens	80-83
7873546-12	1995	Amino acid sequencing unambiguously identified the heparin-protected lysines as Lys 13 and Lys 87, located on the N-terminal and C-terminal domains of MPI, respectively.	Lysine	69-76	secretory leukocyte peptidase inhibitor	Homo sapiens	151-154
7873546-12	1995	Amino acid sequencing unambiguously identified the heparin-protected lysines as Lys 13 and Lys 87, located on the N-terminal and C-terminal domains of MPI, respectively.	Lysine	80-83	secretory leukocyte peptidase inhibitor	Homo sapiens	151-154
7873546-12	1995	Amino acid sequencing unambiguously identified the heparin-protected lysines as Lys 13 and Lys 87, located on the N-terminal and C-terminal domains of MPI, respectively.	Lysine	91-94	secretory leukocyte peptidase inhibitor	Homo sapiens	151-154
7663397-8	1995	Weak interactions of the enzymes with thrombin receptor and inhibitor were ascribed to the incomplete formation of a lysine-cation cluster necessary for electrostatic molecular recognition.	Lysine	117-123	coagulation factor II, thrombin	Homo sapiens	38-46
7873582-1	1995	Factor XIIIa belongs to a family of ubiquitous transglutaminases, which catalyze formation of covalent bonds between the epsilon-amino group of specific lysines and the gamma-carboxyl group of glutamines.	Lysine	153-160	coagulation factor XIII A chain	Homo sapiens	0-12
7852411-1	1995	Tissue plasminogen activator (tPA) was fractionated using lysine-Sepharose affinity chromatography.	Lysine	58-64	plasminogen activator, tissue type	Homo sapiens	0-34
7814414-0	1995	Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.	Lysine	12-18	insulin	Homo sapiens	69-76
7541791-4	1995	These findings suggest that Lys-27, Lys-47, and Arg-28 residues may be related to the direct binding to nAChR, and that there is no involvement of Lys-27 in the antigenic determinants of cobrotoxin.	Lysine	28-31	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	104-109
7529879-1	1995	The L5178Y murine lymphoma subline LY-R is twofold more resistant to killing by ionizing radiation than the subline LY-S.	Lysine	116-120	lymphoma resistance	Mus musculus	35-39
7529879-2	1995	In contrast, LY-R cells are more sensitive to killing by hydrogen peroxide: at 37 degrees C LY-R cells are 1.4 times more sensitive to the killing effect of H2O2 than LY-S cells.	Lysine	167-171	lymphoma resistance	Mus musculus	13-17
7543205-3	1995	Here the labelling efficiency of a recombinant anti-human alpha-fetoprotein (hAFP) Fab fragment has been improved by increasing its lysine content by protein engineering.	Lysine	132-138	alpha fetoprotein	Homo sapiens	58-75
7758222-14	1995	It could, however, be explained by glycation of lysine residues in apolipoprotein A-I, which is the most potent activator of LCAT.	Lysine	48-54	apolipoprotein A1	Homo sapiens	67-85
7896081-3	1995	Oligonucleotide mediated site-directed mutagenesis of PIS at codon 114 revealed that mutant genes with codons for Ala, Thr and Leu could support yeast cell growth in vivo, but those for Asp, Lys and Tyr could not.	Lysine	191-194	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	54-57
7829248-2	1995	TGase2 catalyzes an acyl-transfer reaction between peptide-bound glutamine residues and primary amines, including the epsilon-amino group of lysine residues.	Lysine	141-147	transglutaminase 2	Homo sapiens	0-6
7818548-4	1995	A kinase-negative point mutant of nPKC epsilon, where Lys at the ATP binding site is altered to Arg, does not cause this enhancement of NF-kappa B activation.	Lysine	54-57	protein kinase C, epsilon	Rattus norvegicus	34-46
7814414-1	1995	Recently we reported the deletion of Lys-121 in one allele of the insulin receptor gene from a child with severe insulin resistance.	Lysine	37-40	insulin	Homo sapiens	66-73
7587650-4	1995	Several linear peptides, incorporating the critical core-D-Trp-Lys-sequence of all active analogues, exhibit selectivity for either sstr3, sstr5 or both, but little affinity for the other three.	Lysine	63-66	somatostatin receptor 5	Rattus norvegicus	139-144
7735231-7	1995	Peptide A-2 contains triple lysine residues and constitutes a hydrophilic region.	Lysine	28-34	ATPase H+ transporting V0 subunit a2	Homo sapiens	8-11
7484384-0	1995	Lysine residues in the coenzyme-binding region of mouse lung carbonyl reductase.	Lysine	0-6	carbonyl reductase 2	Mus musculus	56-79
8568566-0	1995	Thrombin inhibitors based on ketone derivatives of arginine and lysine.	Lysine	64-70	coagulation factor II, thrombin	Homo sapiens	0-8
7601731-8	1995	Infusion of 2,3-DHP resulted in a plasma 2,3-DHP content of 9.4 mumol/L and increased plasma THR, ARG, VAL, PHE, ILE, LEU, and LYS concentrations (P &lt; .10).	Lysine	127-130	dihydropyrimidinase	Homo sapiens	16-19
7703285-7	1995	Cotransfection by [Lys]21kD-SP-A-DNA and [Lys]10kD-SP-B resulted in an additive level of reporter gene (CAT) expression.	Lysine	19-22	catalase	Homo sapiens	104-107
7703285-7	1995	Cotransfection by [Lys]21kD-SP-A-DNA and [Lys]10kD-SP-B resulted in an additive level of reporter gene (CAT) expression.	Lysine	42-45	catalase	Homo sapiens	104-107
7811262-1	1994	It has been recently reported that the 72 kDa proteolytic enzyme gelatinase A/type IV collagenase/matrix metalloproteinase 2 (MMP2) hydrolyzed the Lys 16-Leu 17 peptide bond of a synthetic decapeptide (YEVHHQKLVFF) representing the soluble A beta sequence of amino acid residues 10-20.	Lysine	147-150	amyloid beta precursor protein	Homo sapiens	240-246
8529100-4	1995	MATERIALS AND METHODS: Nuclear localization signals (NLS) in general and the HIV-1 MA p17 NLS in particular are characterized by a stretch of positively charged amino acids including one or more lysine residues.	Lysine	195-201	family with sequence similarity 72 member B	Homo sapiens	86-89
8817679-5	1995	Mutation of the lysine 211 resulted in no change in the affinity of IGFBP-5 for ECM or heparin Sepharose; however, it resulted in a major reduction in affinity for IGF-I following heparin binding.	Lysine	16-22	insulin like growth factor 1	Homo sapiens	164-169
7989377-10	1994	This fragment contains a single lysine residue (Lys324) which is only labeled by [35S]oGTP gamma S. Lys324 is unique to Gs alpha and lies within its effector binding region.	Lysine	32-38	GNAS complex locus	Homo sapiens	120-128
7949104-9	1994	The R-PK activity is expected to be severely affected, because the mutated amino acid residue is located between the 313 Lys and the 315 Glu, which are very important for acid-base catalysis and magnesium binding, respectively.	Lysine	121-124	pyruvate kinase L/R	Homo sapiens	4-8
7991593-9	1994	A highly basic, lysine-rich motif of the predicted ELL protein is homologous to similar regions of several proteins, including the DNA-binding domain of poly(ADP-ribose) polymerase.	Lysine	16-22	poly(ADP-ribose) polymerase 1	Homo sapiens	153-180
7982963-6	1994	Substitution of a lysine residue at position 2 in this peptide by tyrosine abolished the specificity difference by increasing the affinities of the DnaK and hsc70 proteins 5- and 20-fold, respectively, and that of BiP by greater than 2 orders of magnitude.	Lysine	18-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	214-217
7699134-0	1994	Effects of graded amounts of duodenal infusions of lysine on the mammary uptake of major milk precursors in dairy cows.	Lysine	51-57	Weaning weight-maternal milk	Bos taurus	89-93
7699134-9	1994	Infusions of Lys tended to increase the efficiency of N utilization and the mammary extraction rates of AA to synthesize more milk proteins.	Lysine	13-16	Weaning weight-maternal milk	Bos taurus	126-130
7981216-0	1994	Lysine 182 of endothelin B receptor modulates agonist selectivity and antagonist affinity: evidence for the overlap of peptide and non-peptide ligand binding sites.	Lysine	0-6	endothelin receptor type B	Homo sapiens	14-35
7982943-7	1994	Automated sequence analysis showed that both modified peptide fractions were derived from the same sequence in AST IV: 63-Leu-Glu-Lys-Cys-Gly-Arg-68.	Lysine	130-133	sulfotransferase family 1A member 1	Rattus norvegicus	111-117
7961906-1	1994	An ion-counterion interaction between the lysine of the NKXD motif in the GTPase domain and an aspartate in the inserted helical domain of alpha subunits of heterotrimeric G proteins, Lys-278 and Asp-158, respectively, of Gs alpha is shown to be essential for activation by AlF4- and partially so for interaction with beta gamma dimers and activation by GTP and receptor.	Lysine	42-48	GNAS complex locus	Homo sapiens	222-230
7961906-1	1994	An ion-counterion interaction between the lysine of the NKXD motif in the GTPase domain and an aspartate in the inserted helical domain of alpha subunits of heterotrimeric G proteins, Lys-278 and Asp-158, respectively, of Gs alpha is shown to be essential for activation by AlF4- and partially so for interaction with beta gamma dimers and activation by GTP and receptor.	Lysine	184-187	GNAS complex locus	Homo sapiens	222-230
7998944-4	1994	In the first step, one of the unique kringle-IVs (K-IVs) in apo-a binds to a Lys residue of apoB; in the second step, Cys-4057 of K-IV type-9 (T-9) forms a disulphide bridge with Cys-3734 of LDL.	Lysine	77-80	apolipoprotein B	Homo sapiens	92-96
7873669-3	1994	They couple with simple amines (n-butylamine and tert-butylamine) and to lysine side chains of proteins (bovine serum albumin and lysozyme) with varying yields.	Lysine	73-79	albumin	Homo sapiens	112-125
7873669-3	1994	They couple with simple amines (n-butylamine and tert-butylamine) and to lysine side chains of proteins (bovine serum albumin and lysozyme) with varying yields.	Lysine	73-79	lysozyme	Homo sapiens	130-138
7873669-5	1994	Differences in reactivity for bovine serum albumin and lysozyme can be explained in terms of differences of isoelectric point and steric local environment around the reactive lysine residue.	Lysine	175-181	albumin	Homo sapiens	37-50
7873669-5	1994	Differences in reactivity for bovine serum albumin and lysozyme can be explained in terms of differences of isoelectric point and steric local environment around the reactive lysine residue.	Lysine	175-181	lysozyme	Homo sapiens	55-63
7713281-0	1994	Lack of in vitro complement activation by the human insulin analogue LYS(b28)PRO(B29)	Lysine	69-72	MIS18 kinetochore protein A	Homo sapiens	73-76
7962321-7	1994	These findings suggest that deletion of lysine-121 in conjunction with a presumed, but thus far unidentified, second mutant allele contributed significantly to the lethal insulin-resistant state in this patient with leprechaunism.	Lysine	40-46	insulin	Homo sapiens	171-178
7961669-2	1994	We have previously shown that a decapeptide sequence between Lys-243 and Glu-252 (KYSFNYDGSE) in the third immunoglobulin (Ig)-like domain of chick neural cell adhesion molecule NCAM is directly involved in NCAM-to-NCAM binding.	Lysine	61-64	neural cell adhesion molecule 1	Mus musculus	207-211
7961669-2	1994	We have previously shown that a decapeptide sequence between Lys-243 and Glu-252 (KYSFNYDGSE) in the third immunoglobulin (Ig)-like domain of chick neural cell adhesion molecule NCAM is directly involved in NCAM-to-NCAM binding.	Lysine	61-64	neural cell adhesion molecule 1	Mus musculus	207-211
7980464-2	1994	Near the thrombin cleavage site in protein C is a cluster of basic residues, at positions P5" (Lys-174), P8" (Arg-177) and P9" (Arg-178).	Lysine	95-98	coagulation factor II, thrombin	Homo sapiens	9-17
7929426-7	1994	The secondary FGFR binding site on bFGF has an approximately 250-fold lower affinity and is composed of amino acids Lys-110, Tyr-111, and Trp-114 in a surface-exposed type I beta-turn (formerly known as the putative receptor binding loop).	Lysine	116-119	fibroblast growth factor 2	Homo sapiens	35-39
7929350-5	1994	We have examined by site-specific mutagenesis of a recombinant PLA2 that is identical to an enzyme in human synovial fluid (containing His-6, Arg-7, Lys-10, and Lys-15 and a global net charge of +15) the role of basic residues in this region in PLA2 action against PLA-deficient (pldA-) E. coli.	Lysine	149-152	phospholipase A2 group IB	Homo sapiens	63-67
7918471-3	1994	We here present direct evidence that HNE derivatization of LDL forms Michael addition-type adducts of HNE with histidine and lysine residues of apolipoprotein B-100 (apoB) and also demonstrate the utility of an antibody specific to the HNE adducts generated in the LDL treated with HNE or oxidatively modified by Cu2+ or cultured endothelial cells.	Lysine	125-131	apolipoprotein B	Homo sapiens	144-164
7918471-3	1994	We here present direct evidence that HNE derivatization of LDL forms Michael addition-type adducts of HNE with histidine and lysine residues of apolipoprotein B-100 (apoB) and also demonstrate the utility of an antibody specific to the HNE adducts generated in the LDL treated with HNE or oxidatively modified by Cu2+ or cultured endothelial cells.	Lysine	125-131	apolipoprotein B	Homo sapiens	166-170
7929356-4	1994	The amino acids are localized in three loops, which form a putative ridge on the most exposed side of the Fc epsilon 3 domain of IgE and include Arg-408, Ser-411, Lys-415, Glu-452, Arg-465, and Met-469.	Lysine	163-166	immunoglobulin heavy constant epsilon	Homo sapiens	129-132
7958904-5	1994	A Lys--&gt;Met mutation created in vitro in the kinase domain led to the loss of rescuing activity and was dominant negative, indicating that the kinase domain of Unc-51 is essential for the function.	Lysine	2-5	Serine/threonine-protein kinase unc-51	Caenorhabditis elegans	163-169
7919379-5	1994	Total blockage of Epo secretion induced by the endoplasmic reticulum-retention amino acids Lys-Asp-Glu-Leu (KDEL) signals in 11 lines prevented autonomous proliferation, whereas a leaky retention system, observed in 3 other lines, resulted in limited autocrine stimulation without true long-term autonomous proliferation.	Lysine	91-94	erythropoietin	Homo sapiens	18-21
7929297-3	1994	The basis for the specificity of this modification with respect to the substrate protein was investigated using fragments of eIF-5A precursor protein, each containing this lysine residue, as substrates for deoxyhypusine synthase, the first enzyme in hypusine synthesis.	Lysine	172-178	deoxyhypusine synthase	Homo sapiens	206-228
7944392-0	1994	Site-directed mutagenesis of a reactive lysyl residue (Lys-247) of Rubisco activase.	Lysine	55-58	ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic	Nicotiana tabacum	67-83
7841367-1	1994	We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways.	Lysine	135-138	proopiomelanocortin	Homo sapiens	107-121
7841367-1	1994	We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways.	Lysine	139-142	proopiomelanocortin	Homo sapiens	107-121
7929288-2	1994	Maturation of the insulin proreceptor in a late Golgi compartment requires cleavage at an Arg-Lys-Arg-Arg processing site, suggesting involvement of furin, a transmembrane serine protease of the Kex2 family of processing enzymes.	Lysine	94-97	insulin	Homo sapiens	18-25
7530934-2	1994	The results show that pyridoxal 5"-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.	Lysine	130-136	CD4 molecule	Homo sapiens	57-60
7944392-4	1994	To further explore the role of Lys-247 in catalysis, this species-invariant residue of Rubisco activase was changed to Arg, Cys, and Gln by mutagenesis of a cDNA clone of the mature form of the tobacco enzyme.	Lysine	31-34	ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic	Nicotiana tabacum	87-103
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	78-81	T cell receptor beta locus	Homo sapiens	102-110
7843797-6	1994	Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen.	Lysine	0-6	fibrinogen beta chain	Homo sapiens	100-110
7843797-6	1994	Lysine as well as the lysine analog 6-aminohexanoic acid (AHA) decreased the inhibitory capacity of fibrinogen.	Lysine	22-28	fibrinogen beta chain	Homo sapiens	100-110
7935367-0	1994	Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation.	Lysine	28-34	Lys14p	Saccharomyces cerevisiae S288C	103-108
7935367-1	1994	The product of the LYS14 gene of Saccharomyces cerevisiae activates the transcription of at least four genes involved in lysine biosynthesis.	Lysine	121-127	Lys14p	Saccharomyces cerevisiae S288C	19-24
8083199-6	1994	The data also show that one source of the large enhancement of kcat/Km for the mutant containing Asp-198 in human carbonic anhydrase III is the presence of both Asp-198 and Lys-64; when Lys-64 was replaced with Ala, a reduction of catalytic activity was observed.	Lysine	173-176	carbonic anhydrase 3	Homo sapiens	114-136
7945192-9	1994	Pulse-chase experiments using [3H]lysine indicated that turnover rates of Cu,Zn-superoxide dismutase in K562 cells were not affected by growth in copper-enriched medium, whereas turnover of total protein was significantly enhanced as a function of metal supplementation.	Lysine	34-40	superoxide dismutase 1	Homo sapiens	74-100
8086489-3	1994	Previously we have reported the involvement of Lys-140 located in the C-terminus of the second transmembrane region of the ETA receptor for ET-1 binding (Eur.	Lysine	47-50	endothelin 1	Homo sapiens	140-144
8086489-8	1994	These results demonstrate that Lys-161 of the receptor is important for high affinity binding with ET-3 which, in part, confers the non-selective binding characteristics of the ETB receptor for ET isopeptides.	Lysine	31-34	endothelin receptor type B	Homo sapiens	177-180
7839726-1	1994	We studied a 45-69 lipopeptide obtained by N-terminal modification with a N epsilon-palmitoyl lysine residue of the 45-69 peptide derived from the nef protein of HIV.	Lysine	94-100	S100 calcium binding protein B	Homo sapiens	147-150
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	82-85	T cell receptor beta locus	Homo sapiens	102-110
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	82-85	T cell receptor beta locus	Homo sapiens	102-110
8080281-0	1994	Myristoylation of protein at a distinct position allows its phosphorylation by protein kinase C. A hydrophilic enzyme, lysozyme, was myristoylated in vitro by the N-hydroxysuccinimide ester of myristic acid and three monomyristoylated lysozymes modified at a distinct position (at Lys-13, Lys-33, Lys-97) were isolated by two-step column chromatography.	Lysine	281-284	lysozyme	Homo sapiens	119-127
8080281-0	1994	Myristoylation of protein at a distinct position allows its phosphorylation by protein kinase C. A hydrophilic enzyme, lysozyme, was myristoylated in vitro by the N-hydroxysuccinimide ester of myristic acid and three monomyristoylated lysozymes modified at a distinct position (at Lys-13, Lys-33, Lys-97) were isolated by two-step column chromatography.	Lysine	289-292	lysozyme	Homo sapiens	119-127
8080281-0	1994	Myristoylation of protein at a distinct position allows its phosphorylation by protein kinase C. A hydrophilic enzyme, lysozyme, was myristoylated in vitro by the N-hydroxysuccinimide ester of myristic acid and three monomyristoylated lysozymes modified at a distinct position (at Lys-13, Lys-33, Lys-97) were isolated by two-step column chromatography.	Lysine	289-292	lysozyme	Homo sapiens	119-127
8063741-11	1994	Annexin-II-mediated enhancement of t-PA-dependent plasminogen activation was 90-95% inhibited by epsilon-aminocaproic acid or by pretreatment of Ann-II with carboxypeptidase B, indicating a carboxyl-terminal lysine-dependent interaction.	Lysine	208-214	plasminogen activator, tissue type	Homo sapiens	35-39
8058339-0	1994	Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).	Lysine	21-24	DNA damage inducible transcript 3	Homo sapiens	58-62
8058339-0	1994	Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).	Lysine	21-24	DNA damage inducible transcript 3	Homo sapiens	64-71
8058339-3	1994	This alteration, though not responsible for the Li-Fraumeni phenotype, resulted in a glutamic acid to lysine switch within the leucine zipper domain, at a residue conserved between CHOP and its potential target molecules and between the human and hamster sequences.	Lysine	102-108	DNA damage inducible transcript 3	Homo sapiens	181-185
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Lysine	46-49	matrix metallopeptidase 3	Homo sapiens	199-204
7841520-5	1994	Vma21p contains a dilysine motif at the carboxy terminus, and mutation of these lysine residues abolishes retention in the endoplasmic reticulum and results in delivery of Vma21p to the vacuole, the default compartment for yeast membrane proteins.	Lysine	20-26	Vma21p	Saccharomyces cerevisiae S288C	0-6
8074690-1	1994	We have previously demonstrated that antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier inhibited neurite outgrowth in NB2a/d1 neuroblastoma cells, and that culturing of these cells on adhesive substrates such as laminin or poly-L-lysine overcame this restriction.	Lysine	275-288	growth associated protein 43	Mus musculus	82-88
8063713-9	1994	The third substrate, NFF-3 (Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2), was hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but there was no significant hydrolysis by MMP-1 and MMP-2.	Lysine	40-43	matrix metallopeptidase 3	Homo sapiens	109-114
8049209-8	1994	Missense mutation analysis indicates that the Lys and Arg residues are essential for calmodulin binding to the synthetic peptide RYR1 PM3.	Lysine	46-49	calmodulin 1	Homo sapiens	85-95
7804168-8	1994	t-PA binding could be reduced about 40% by the addition of 10 mmol l-1 of the lysine analogue epsilon-aminocaproic acd (EACA) whereas no inhibitory effect could be demonstrated with arginine.	Lysine	78-84	plasminogen activator, tissue type	Homo sapiens	0-4
8049245-2	1994	Exposure of HGL to trypsin led to the production of three identified fragments (H1, H2 and H3) resulting from cleavage sites at Lys-4 and Arg-229.	Lysine	128-131	lipase F, gastric type	Homo sapiens	12-15
7832981-0	1994	Reductive methylation and pKa determination of the lysine side chains in calbindin D9k.	Lysine	51-57	S100 calcium binding protein G	Homo sapiens	73-86
8040332-6	1994	Although loss of reactive lysine groups could be due to either oxidative modification or nonenzymatic glycation of apolipoprotein B-100, inhibition of lipid peroxidation by the metal chelator, diethylenetriamine pentaacetic acid, blocked the changes in free lysines.	Lysine	26-32	apolipoprotein B	Homo sapiens	115-135
7832981-1	1994	The Lys residues in the 75-residue Ca(2+)-binding protein calbindin D9k were reductively methylated with 13C-enriched formaldehyde.	Lysine	4-7	S100 calcium binding protein G	Homo sapiens	58-71
7832981-5	1994	The pKa values of the individual Lys residues in Ca(2+)-calbindin D9k and apo-calbindin D9k were obtained by combining pH titration experiments and (1H, 13C)-HMQC NMR spectroscopy.	Lysine	33-36	S100 calcium binding protein G	Homo sapiens	56-69
7832981-5	1994	The pKa values of the individual Lys residues in Ca(2+)-calbindin D9k and apo-calbindin D9k were obtained by combining pH titration experiments and (1H, 13C)-HMQC NMR spectroscopy.	Lysine	33-36	S100 calcium binding protein G	Homo sapiens	78-91
7832981-6	1994	Each Lys residue in the Ca(2+)- and apo-forms of calbindin D9k has a unique pKa value.	Lysine	5-8	S100 calcium binding protein G	Homo sapiens	49-62
7832981-8	1994	Although apo-calbindin D9k has a very similar structure compared to Ca(2+)-calbindin D9k, the removal of two Ca2+ ions from the protein leads to an increase of the pKa values of the Lys residues.	Lysine	182-185	S100 calcium binding protein G	Homo sapiens	13-26
7990980-6	1994	It is concluded that linkage at the B29-lysines, and not at the B1-phenylalanine, leads to partial agonism of dimerized insulin derivatives, regardless of the length of the crosslinker.	Lysine	40-47	CD79B antigen	Mus musculus	36-39
8041717-5	1994	Frog DBI contains two paired basic amino acids (Lys-Lys) at positions 14-15 and 62-63 and a single cysteine within the biologically active region of the molecule.	Lysine	48-51	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	5-8
7971711-3	1994	In contrast, Phe-B1 and Lys-B29 diacylated insulins were more susceptible to hydrolysis than native insulin.	Lysine	24-27	insulin	Homo sapiens	43-50
8041717-5	1994	Frog DBI contains two paired basic amino acids (Lys-Lys) at positions 14-15 and 62-63 and a single cysteine within the biologically active region of the molecule.	Lysine	52-55	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	5-8
8048626-4	1994	The fractional synthesis rates of fibrinogen and albumin calculated using the isotopic enrichments of apoB-bound lysine, leucine, and alanine as the precursor were similar to those based on plasma alanine.	Lysine	113-119	apolipoprotein B	Homo sapiens	102-106
7958544-0	1994	Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM.	Lysine	133-136	insulin	Homo sapiens	115-122
7958544-0	1994	Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM.	Lysine	133-136	MIS18 kinetochore protein A	Homo sapiens	137-140
7912697-9	1994	Other motifs found in the Atpk1 protein include two putative autophosphorylation sites, a pseudosubstrate site, two acidic domains, a lysine-rich domain, and two putative PEST sequences, which may contribute to the regulation of protein kinase activity.	Lysine	134-140	protein-serine kinase 1	Arabidopsis thaliana	26-31
7518267-0	1994	Lysine residues in bee venom phospholipase A2 are important for binding to human monoclonal or polyclonal antibodies of the IgG4 isotope.	Lysine	0-6	phospholipase A2 group IB	Homo sapiens	29-45
7518267-2	1994	Lysine residues of PLA have been specifically modified by acetylation or acylation by treatment with citraconic anhydride of their epsilon-amino groups to analyze their role in antigen-antibody binding.	Lysine	0-6	phospholipase A2 group IB	Homo sapiens	19-22
7518267-5	1994	The data indicate the importance of lysine residues as being part of B cell epitopes in PLA-specific antibodies of the IgG4 isotype, but less so for those of the IgE isotype.	Lysine	36-42	phospholipase A2 group IB	Homo sapiens	88-91
7959867-5	1994	Both PHA-activated CD4+ and CD8+ T cells have increased lysine transport through y+, and in seven out of eight experiments, more activity was seen in the CD8+ fraction.	Lysine	56-62	CD4 molecule	Homo sapiens	19-22
8206999-9	1994	This revealed that CaM residues Thr-110, Leu-112, and Lys-115 were critical for full smMLCK activation and could not be substituted by the corresponding cTnC residue (Gln, Thr, and Thr, respectively).	Lysine	54-57	calmodulin 1	Homo sapiens	19-22
7911508-4	1994	In contrast, incubation with the D2 agonists [LY 171555, (+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine, RU 24213] increased the soluble and decreased the particulate PKC activity.	Lysine	46-48	proline rich transmembrane protein 2	Homo sapiens	165-168
8011637-6	1994	Lysines in this region were mutated to glutamates, and the kinetics for the inhibition of thrombin by mutant proteins were determined.	Lysine	0-7	coagulation factor II	Rattus norvegicus	90-98
8091399-3	1994	t-PA inhibited WP aggregation only in the presence of lys- or glu-plasminogen.	Lysine	54-57	plasminogen activator, tissue type	Homo sapiens	0-4
8091399-5	1994	t-PA alone also decreased 14C-serotonin release from WP, and lys- as well as glu-plasminogen reversed this effect of low concentrations of t-PA in WP.	Lysine	61-64	plasminogen activator, tissue type	Homo sapiens	139-143
8077841-14	1994	Lysine-Sepharose chromatography of plasma yielded retained products that contained apo[a] and apoB-100 but not apoB-38.9.	Lysine	0-6	apolipoprotein B	Homo sapiens	94-98
8202484-7	1994	Sca-2 is a member of the Ly-6 family, a group of small cysteine-rich cell surface proteins that are anchored in the membrane by a glycosyl-phosphatidylinositol moiety.	Lysine	25-27	lymphocyte antigen 6 complex, locus E	Mus musculus	0-5
7980208-8	1994	RESULTS: Investigation showed that the proband was homozygous for the Pi Null Bellingham variant of alpha-1-antitrypsin due to the mutation Lys 217 (AAG) to Stop (TAG).	Lysine	140-143	serpin family A member 1	Homo sapiens	100-119
8077841-14	1994	Lysine-Sepharose chromatography of plasma yielded retained products that contained apo[a] and apoB-100 but not apoB-38.9.	Lysine	0-6	apolipoprotein B	Homo sapiens	94-102
7850269-2	1994	This mutation predicts a substitution of lysine for threonine at one of the glycosylation sites in the rhodopsin molecule (Thr4Lys).	Lysine	41-47	rhodopsin	Homo sapiens	103-112
8196623-2	1994	The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the third and fourth WT1 zinc fingers which disrupts binding to a previously defined WT1-EGR1 binding site.	Lysine	81-87	WT1 transcription factor	Homo sapiens	169-172
8196623-2	1994	The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the third and fourth WT1 zinc fingers which disrupts binding to a previously defined WT1-EGR1 binding site.	Lysine	81-87	WT1 transcription factor	Homo sapiens	233-236
8189069-4	1994	The interaction of PLA2 with these two Abs has previously been shown to depend on the conformation of the Ag and to be sensitive to lysine modifications.	Lysine	132-138	phospholipase A2 group IB	Homo sapiens	19-23
7850270-1	1994	A mutation in codon 181 (Glu--&gt;Lys) of the rhodopsin gene in a Japanese family.	Lysine	34-37	rhodopsin	Homo sapiens	46-55
7850270-2	1994	The PCR/restriction endonuclease digestion (RE) assay and PCR/SSCP analysis of the rhodopsin gene in 13 Japanese families with autosomal dominant retinitis pigmentosa (ad RP) revealed a G-A substitution of the first nucleotide of codon 181, replacing Glu (GAG) with Lys (AAG), in one family.	Lysine	266-269	rhodopsin	Homo sapiens	83-92
7961591-4	1994	On the other hand, dextran sulfate and poly-L-lysine with chain lengths of &gt; 20.5 kDa inhibited the EGF-R kinase activity.	Lysine	39-52	epidermal growth factor receptor	Homo sapiens	103-108
8182054-5	1994	Biochemical modification of lysine residues on cathepsin L with sulfo-N-hydroxysuccinimide acetate prevented the enzyme from being phosphorylated, indicating that lysine is an important component of the signal.	Lysine	28-34	cathepsin L	Homo sapiens	47-58
8182054-5	1994	Biochemical modification of lysine residues on cathepsin L with sulfo-N-hydroxysuccinimide acetate prevented the enzyme from being phosphorylated, indicating that lysine is an important component of the signal.	Lysine	163-169	cathepsin L	Homo sapiens	47-58
8168934-5	1994	We propose that the portion of the first N-terminal extracellular loop of the FMLP receptor containing residues Arg-84 and Lys-85 contributes significantly to the active site in ligand-receptor binding.	Lysine	123-126	formyl peptide receptor 1	Homo sapiens	78-91
7961591-7	1994	The compounds enhancing the EGF-R activity, such as poly-L-lysine, protamine, and poly-L-arginine, down-modulated the autophosphorylation reaction.	Lysine	52-65	epidermal growth factor receptor	Homo sapiens	28-33
8168623-2	1994	The mutations in both strains alter the initiating methionine codon in the ATP5 gene: ATG to ATA (Ile) and AAG (Lys).	Lysine	112-115	F1F0 ATP synthase subunit 5	Saccharomyces cerevisiae S288C	75-79
7909358-2	1994	Using altered DNA specificity Bicoid mutants and appropriate reporter genes, we show that Bicoid distinguishes among related DNA-binding sites in vivo by a specific contact between amino acid 9 of its recognition alpha-helix (lysine 50 of the homeodomain) and bp 7 of the site.	Lysine	226-232	bicoid	Drosophila melanogaster	90-96
8176707-7	1994	Modeled structures of several isocoumarins noncovalently complexed with human alpha-thrombin suggest that H-bonding between the 7-substituent and the Lys-60F NH3+ relates to the inhibitory potency.	Lysine	150-153	coagulation factor II, thrombin	Homo sapiens	84-92
8142399-14	1994	The P1 Arg and Lys mutants also significantly inhibited thrombin, factor XIa, activated protein C, plasmin, factor XIIa, kallikrein, and bovine trypsin and chymotrypsin but did not inhibit tissue factor.factor VIIa, t-PA, or HLE.	Lysine	15-18	plasminogen activator, tissue type	Bos taurus	216-220
8155694-0	1994	Involvement of lysine residues of goat serum albumin in high-affinity binding of bilirubin.	Lysine	15-21	albumin	Homo sapiens	45-52
8155694-7	1994	These results prove the involvement of lysine residues in bilirubin-albumin interaction.	Lysine	39-45	albumin	Homo sapiens	68-75
8006045-2	1994	The data indicate that the sulfonated material has a high affinity for both fibrinogen and plasminogen, but that the ratio of plasminogen to fibrinogen is greater on the lysine-derivatized surface.	Lysine	170-176	fibrinogen beta chain	Homo sapiens	141-151
7511933-8	1994	Sera from apoE-deficient mice also contained circulating autoantibodies to MDA-lysine, and both early and advanced lesions were rich in murine immunoglobulins.	Lysine	79-85	apolipoprotein E	Mus musculus	10-14
8006045-4	1994	The plasmin activity of plasminogen adsorbed to the lysine-derivatized silica glass and its sulfonated precursor was assessed by both a chromogenic substrate assay and a radioimmunoassay for the plasmin cleavage product of fibrinogen, the B beta 1-42 peptide.	Lysine	52-58	fibrinogen beta chain	Homo sapiens	223-233
7913755-3	1994	CJD in this community segregates with a point mutation at codon 200 of the PrP gene which causes the substitution of lysine for glutamate.	Lysine	117-123	prion protein	Homo sapiens	75-78
7912945-11	1994	The results showed a point mutation in the PrP gene at codon 200; GAG to AAG (Glu--&gt;Lys).	Lysine	87-90	prion protein	Homo sapiens	43-46
8073394-0	1994	Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis.	Lysine	22-28	plasminogen activator, tissue type	Homo sapiens	42-46
8146151-6	1994	For [Lys]10kDa-SP-B.pCPA-RSV preparations, CAT activity was readily detectable above the background of [Lys]3.3kDa-SP-B or unmodified SP-B.	Lysine	5-8	surfactant protein B	Bos taurus	15-19
8146151-9	1994	Addition of replication-defective adenovirus to the [Lys]10kDa-SP-B.pCPA-RSV complex enhanced CAT activity about 30-fold with respect to that produced by the [Lys]10kDa-SP-B.pCPA-RSV complex alone.	Lysine	53-56	surfactant protein B	Bos taurus	63-67
8146151-9	1994	Addition of replication-defective adenovirus to the [Lys]10kDa-SP-B.pCPA-RSV complex enhanced CAT activity about 30-fold with respect to that produced by the [Lys]10kDa-SP-B.pCPA-RSV complex alone.	Lysine	53-56	surfactant protein B	Bos taurus	169-173
8146151-13	1994	Results of FTIR indicated that the conformation of [Lys]10kDa-SP-B was comprised primarily of alpha-helical structure compared with a predominantly aggregated structure of unmodified poly(lysine).	Lysine	52-55	surfactant protein B	Bos taurus	62-66
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Lysine	142-145	vasoactive intestinal polypeptide	Mus musculus	76-79
8073394-1	1994	The lysine analogues epsilon-aminocaproic acid (EACA) and trans-4-amino-methyl cyclohexane carboxylic acid (AMCA) are used to prevent excessive bleeding in patients with coagulopathies, such as hemophilia and thrombocytopenia, or in those who have received tissue plasminogen activator (t-PA).	Lysine	4-10	plasminogen activator, tissue type	Homo sapiens	257-291
8073394-3	1994	The present study utilized blood from normal volunteers and 125I-fibrinogen in a dilute whole blood clot assay to determine the relative concentrations of lysine analogues required for inhibition of clot lysis induced by exogenous t-PA.	Lysine	155-161	plasminogen activator, tissue type	Homo sapiens	231-235
8073394-8	1994	The data suggest that lysine analogues, even at low concentrations, reduce the rate of t-PA induced whole blood clot lysis by several mechanisms.	Lysine	22-28	plasminogen activator, tissue type	Homo sapiens	87-91
8031876-3	1994	In an effort to prolong its in vivo residence time even further, we have modified CD4-IgG chemically by attaching monomethoxypoly(ethylene glycol) (MePEG) moieties to lysine residues via reductive alkylation.	Lysine	167-173	CD4 molecule	Homo sapiens	82-85
8123667-1	1994	Calmodulin (lysine 115) N-methyltransferase was purified from the cytosolic fraction of Paramecium tetraurelia by sequential dialysis, cellulose phosphate chromatography, Reactive Red 120 agarose chromatography, and calmodulin-Sepharose affinity chromatography.	Lysine	12-18	calmodulin 1	Homo sapiens	0-10
8123667-4	1994	The enzyme formed a mixture of mono-, di-, and trimethyllysine residues at lysine 115 of calmodulin in vitro, had a Km for the methyl donor, S-adenosyl methionine (AdoMet), of about 1 microM and a pH optimum of about 7.5.	Lysine	56-62	calmodulin 1	Homo sapiens	89-99
8123667-11	1994	Only calmodulins with an unmethylated lysine at residue 115, including cam2 calmodulin, were substrates.	Lysine	38-44	calmodulin 1	Homo sapiens	5-15
8123669-5	1994	Peptide mapping analysis revealed that PEG-PPG binding sites were mainly determined to be Lys 35, 46, 61, 98, 120 and 135 in A-chain and Lys 211, 300, 318, 338, 348, 383 and 404 in B-chain.	Lysine	90-93	serglycin	Homo sapiens	43-46
8123669-5	1994	Peptide mapping analysis revealed that PEG-PPG binding sites were mainly determined to be Lys 35, 46, 61, 98, 120 and 135 in A-chain and Lys 211, 300, 318, 338, 348, 383 and 404 in B-chain.	Lysine	137-140	serglycin	Homo sapiens	43-46
7907550-2	1994	Since the filaggrin linker segment peptide was efficiently conjugated with P-cystatin alpha and was mediated by epidermal TGase in the presence of Ca2+ ions, filaggrin is a candidate for the glutamine-rich linkage protein to conjugate with lysine-rich P-cystatin alpha.	Lysine	240-246	filaggrin	Rattus norvegicus	10-19
7907550-2	1994	Since the filaggrin linker segment peptide was efficiently conjugated with P-cystatin alpha and was mediated by epidermal TGase in the presence of Ca2+ ions, filaggrin is a candidate for the glutamine-rich linkage protein to conjugate with lysine-rich P-cystatin alpha.	Lysine	240-246	filaggrin	Rattus norvegicus	158-167
8107847-8	1994	This demonstrates the proximity of Asp 90 and Lys 296 in the three-dimensional structure of rhodopsin and suggests that the constitutively activating mutations operate by a common molecular mechanism, disrupting a salt bridge between Lys 296 and the Schiff base counterion, Glu 113.	Lysine	46-49	rhodopsin	Homo sapiens	92-101
8152418-7	1994	Streptomycin resistance is associated with an A--&gt;C change at codon 87 of rps12 (converting a lysine into a glutamine), three codons upstream from a mutation earlier reported for Nicotiana.	Lysine	97-103	rps12	Solanum nigrum	77-82
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Lysine	76-79	eukaryotic translation elongation factor 2	Rattus norvegicus	148-167
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Lysine	76-79	eukaryotic translation elongation factor 2	Rattus norvegicus	169-173
8117101-2	1994	Interaction of Pg with small ligands such as lysine or macromolecular ligands such as fibrin induces a dramatic conformational change in the zymogen which enhances its efficacy as a t-PA substrate, thereby increasing catalytic efficiency of the activation reaction.	Lysine	45-51	plasminogen activator, tissue type	Homo sapiens	182-186
8119968-3	1994	Using site-directed mutagenesis, we have introduced furin consensus cleavage sequences (Arg-X-Lys-Arg) into the human proinsulin cDNA.	Lysine	94-97	insulin	Homo sapiens	118-128
8106489-6	1994	By comparison of the 1H-13C heteronuclear multiple quantum coherence spectra of 13C-dimethylated calmodulin samples from bovine testis and E. coli, the resonance for Lys-115 in bacterially expressed calmodulin could be identified.	Lysine	166-169	calmodulin	Bos taurus	97-107
8106489-6	1994	By comparison of the 1H-13C heteronuclear multiple quantum coherence spectra of 13C-dimethylated calmodulin samples from bovine testis and E. coli, the resonance for Lys-115 in bacterially expressed calmodulin could be identified.	Lysine	166-169	calmodulin	Bos taurus	199-209
8106489-7	1994	pH titration experiments showed that epsilon-NH2 group of Lys-115 has a normal pKa value both in the apo and Ca2+ forms of the protein and in a complex of calmodulin with a 22-residue calmodulin-binding peptide derived from myosin light chain kinase.	Lysine	58-61	calmodulin	Bos taurus	155-165
8106489-7	1994	pH titration experiments showed that epsilon-NH2 group of Lys-115 has a normal pKa value both in the apo and Ca2+ forms of the protein and in a complex of calmodulin with a 22-residue calmodulin-binding peptide derived from myosin light chain kinase.	Lysine	58-61	calmodulin	Bos taurus	184-194
8107847-8	1994	This demonstrates the proximity of Asp 90 and Lys 296 in the three-dimensional structure of rhodopsin and suggests that the constitutively activating mutations operate by a common molecular mechanism, disrupting a salt bridge between Lys 296 and the Schiff base counterion, Glu 113.	Lysine	234-237	rhodopsin	Homo sapiens	92-101
8116235-4	1994	Domain-swapping and site-directed mutagenesis experiments indicated that codon 9 of the core protein coding sequence played a crucial role on the synthesis of the core protein: a lysine codon at this position led to the synthesis of P16 and an arginine codon at this position led to the synthesis of P21.	Lysine	179-185	cyclin dependent kinase inhibitor 2A	Homo sapiens	233-236
8112348-6	1994	The binding of t-PA to fibrin and to immobilized FCB-2 was partially inhibited by the lysine analogue 6-aminohexanoic acid (Ki = 123 +/- 47 microM and 364 microM, respectively) but was not modified by carboxypeptidase B, thus indicating involvement of internal lysine residues.	Lysine	86-92	plasminogen activator, tissue type	Homo sapiens	15-19
7906267-0	1994	Mutation of Glu-80--&gt;Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex.	Lysine	24-27	coagulation factor II, thrombin	Homo sapiens	115-123
8112348-6	1994	The binding of t-PA to fibrin and to immobilized FCB-2 was partially inhibited by the lysine analogue 6-aminohexanoic acid (Ki = 123 +/- 47 microM and 364 microM, respectively) but was not modified by carboxypeptidase B, thus indicating involvement of internal lysine residues.	Lysine	261-267	plasminogen activator, tissue type	Homo sapiens	15-19
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	11-17	plasminogen activator, tissue type	Homo sapiens	130-134
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	11-17	plasminogen activator, tissue type	Homo sapiens	250-254
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	130-134
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	130-134
8112348-9	1994	Altogether, these data indicate that the mechanism of binding of t-PA to fibrin involves mainly a lysine-independent interaction with the D region which is contributed by sequences present in FCB-5 and FCB-2; contribution to binding by a lysine-dependent interaction was detected only in FCB-2 and is probably of minor relevance as suggested by the limited effect of 6-aminohexanoic acid.	Lysine	98-104	plasminogen activator, tissue type	Homo sapiens	65-69
8112348-9	1994	Altogether, these data indicate that the mechanism of binding of t-PA to fibrin involves mainly a lysine-independent interaction with the D region which is contributed by sequences present in FCB-5 and FCB-2; contribution to binding by a lysine-dependent interaction was detected only in FCB-2 and is probably of minor relevance as suggested by the limited effect of 6-aminohexanoic acid.	Lysine	238-244	plasminogen activator, tissue type	Homo sapiens	65-69
8275497-1	1994	We investigated the expression of p53 in paraformaldehyde-lysine-periodate fixed normal and chronic myelogenous leukemia (CML) hemopoietic cells with flow cytometry and two monoclonal antibodies, PAb1801 and the mutant-conformation-associated PAb240.	Lysine	58-64	tumor protein p53	Homo sapiens	34-37
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Lysine	37-40	coagulation factor II, thrombin	Homo sapiens	61-69
8307029-1	1994	The Saccharomyces cerevisiae KEX1 gene encodes a carboxypeptidase involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1 and K2 killer toxins and alpha-factor (mating pheromone).	Lysine	111-117	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	29-33
8307029-11	1994	Insect-cell-derived Kex1 delta p processes alpha-factor-Lys-Arg, a known natural substrate, to mature active alpha-factor in a manner similar to the membrane-associated full-length enzyme.	Lysine	56-59	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	20-24
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Lysine	50-53	coagulation factor II, thrombin	Homo sapiens	61-69
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Lysine	50-53	coagulation factor II, thrombin	Homo sapiens	208-216
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	211-214	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	211-214	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	211-214	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	220-223	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	220-223	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Lysine	220-223	coagulation factor II, thrombin	Homo sapiens	107-115
7858176-5	1994	The epidemiological data suggests a very high familial incidence of CJD in this population and a molecular genetic research elucidated that CJD segregates with a point mutation at codon 200 of the PrP gene resulting in the substitution of Lysine for Glutamate.	Lysine	239-245	prion protein	Homo sapiens	197-200
8190118-1	1994	The role of the primary amino groups of lysine sidechains in Ca2+ binding to calreticulin was evaluated by chemical modification of the amino group with 2,4,6-trinitrobenzenesulfonic acid (TNBS).	Lysine	40-46	calreticulin	Homo sapiens	77-89
7762422-2	1994	Fluorescein isothiocyanate derivatization of human lactotransferrin on Lys-264 as well as covalent addition of sulfosuccinimidyl 2-(p-azidosalicylamido)ethyl-1,3"- dithiopropionate (SASD)* on Lys-74 inhibits the binding of the glycoprotein to both human PHA-activated lymphocytes and non-activated platelets.	Lysine	71-74	lactotransferrin	Homo sapiens	51-67
7762422-3	1994	This suggests that the cell binding site of lactotransferrin is located in the vicinity of the lysine residues 74 &amp; 264 and does not occur either through electrostatic or lectin interactions.	Lysine	95-101	lactotransferrin	Homo sapiens	44-60
7762422-4	1994	In contrast, the derivatization of lactotransferrin using sulfosuccinimidyl 6-(4"-azido-2"-nitrophenyl-amino) hexanoate (sulfo-SANPAH), on Lys-281 does not modify the binding parameters of lactotransferrin to the cells.	Lysine	139-142	lactotransferrin	Homo sapiens	35-51
8190118-8	1994	In the C-domain of calreticulin, which contains the low affinity/high capacity Ca2+ binding sites, acidic residues are interspersed at regular intervals with one or more positively charged lysine and arginine residues.	Lysine	189-195	calreticulin	Homo sapiens	19-31
8190118-9	1994	Our results indicate that the aminogroups of the lysine sidechains in the C-domain of calreticulin have a role in the low affinity/high capacity Ca2+ binding that is characteristic of this region of the protein and which is proposed to contribute significantly to the capacity of the endoplasmic reticulum Ca2+ store.	Lysine	49-55	calreticulin	Homo sapiens	86-98
8187235-9	1994	Since plasminogen bound to carboxy-terminal lysines of progressively degraded fibrin or membranes is readily transformed into plasmin by fibrin-bound t-PA, this mechanism represents the most important pathway for the acceleration and amplification of fibrinolysis.	Lysine	44-51	plasminogen activator, tissue type	Homo sapiens	150-154
7903302-11	1993	The Arg-Lys sequence at positions 25-31, which resembles the binding site of apolipoprotein E, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor with high efficiency.	Lysine	8-11	apolipoprotein E	Rattus norvegicus	77-93
8264648-0	1994	Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes.	Lysine	27-33	neurofibromin 1	Homo sapiens	42-55
8264648-1	1994	Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1.	Lysine	0-6	neurofibromin 1	Homo sapiens	15-28
8264648-1	1994	Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1.	Lysine	0-6	neurofibromin 1	Homo sapiens	69-72
8264648-1	1994	Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1.	Lysine	0-6	neurofibromin 1	Homo sapiens	115-118
8264648-4	1994	Functional assays using yeast ira complementation have revealed that lysine is the only amino acid that produced functional NF1.	Lysine	69-75	neurofibromin 1	Homo sapiens	124-127
8264648-8	1994	This was first indicated by the finding that defective NF1s due to an alteration of lysine 1423 to other amino acids can be rescued by a second site intragenic mutation at residue 1434.	Lysine	84-90	neurofibromin 1	Homo sapiens	55-58
8187245-3	1994	The latter is a highly electropositive surface near the C-terminal helix of thrombin abundant in arginine and lysine residues.	Lysine	110-116	coagulation factor II, thrombin	Homo sapiens	76-84
8187245-9	1994	The Lys35 is located on a turn of the helix, which causes it to project into solvent space in the fragment 2-thrombin complex, thereby devastating the cationic center of the lysine binding site.	Lysine	174-180	coagulation factor II, thrombin	Homo sapiens	109-117
8001706-4	1994	Lys B28-Pro B29 analogue is under clinical investigation to answer the following questions: does this analogue administered immediately before meal al decrease glycaemic excursions and the number of hypoglycemic episodes after meals compared to regular insulin administered 30 minutes before meal?	Lysine	0-3	insulin	Homo sapiens	253-260
8258344-7	1993	Evidence from mouse cells transfected with mutant B27 genes suggests that a unique lysine at position 70 in the wild-type molecule increases reactivity to thiol-reactive metabolites.	Lysine	83-89	melanocortin 2 receptor accessory protein	Homo sapiens	50-53
7902354-8	1993	These results directly demonstrate that Tyr-236 and Lys-154 are indeed critical for the catalytic activity, lisinopril inhibition, and NaCl activation of ACET.	Lysine	52-55	angiotensin I converting enzyme	Homo sapiens	154-158
8136018-11	1993	alpha-Thrombin with chemically modified lysines in both anion-binding exosite-I and -II has no heparin accelerated thrombin inhibition by either AT or HC.	Lysine	40-47	coagulation factor II, thrombin	Homo sapiens	6-14
8136018-12	1993	Thrombin lysine-modified in the presence of heparin has protected residues in anion-binding exosite-II and the loss of heparin-accelerated inhibition by HC is greater than that by AT.	Lysine	9-15	coagulation factor II, thrombin	Homo sapiens	0-8
8136020-0	1993	Carbon-13 NMR studies of the lysine side chains of calmodulin and its proteolytic fragments.	Lysine	29-35	calmodulin	Bos taurus	51-61
8136020-1	1993	The pH-titration and dynamic behaviour of the seven lysine side chains in bovine calmodulin were studied by carbon-13 NMR.	Lysine	52-58	calmodulin	Bos taurus	81-91
8226847-7	1993	The titration behavior of apoA-I Lys residues is generally similar in the presence and absence of cholesterol, except that 4 Lys residues titrate at a significantly higher pH in the presence of cholesterol.	Lysine	33-36	apolipoprotein A1	Homo sapiens	26-32
8218271-7	1993	We propose that uptake of the Fe(3+)-transferrin complex into an acidic endosome (viz., pH approximately 5.0) via receptor-mediated endocytosis will result in the protonation of both lysine residues.	Lysine	183-189	transferrin	Homo sapiens	37-48
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Lysine	94-97	fibroblast growth factor 2	Homo sapiens	152-156
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Lysine	94-97	fibroblast growth factor 2	Homo sapiens	246-250
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Lysine	178-181	fibroblast growth factor 2	Homo sapiens	152-156
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Lysine	178-181	fibroblast growth factor 2	Homo sapiens	152-156
8226847-7	1993	The titration behavior of apoA-I Lys residues is generally similar in the presence and absence of cholesterol, except that 4 Lys residues titrate at a significantly higher pH in the presence of cholesterol.	Lysine	125-128	apolipoprotein A1	Homo sapiens	26-32
8240272-5	1993	In the pancreas, there were unmodified, mono- and di-phosphorylated forms of the fragment chromogranin A(248-313) with Arg and Glu at positions 293 and 301 respectively; in addition, there were small amounts of monophosphorylated peptide with an alternative primary sequence of His and Lys at 293 and 301 respectively.	Lysine	286-289	chromogranin A	Bos taurus	90-104
7694154-2	1993	Mutations at Lys 335 and Arg 347 in the sixth predicted transmembrane helix of CFTR alter its halide selectivity in whole-cell studies and its single channel conductance, but the physical basis of these alterations is unknown and permeation in CFTR is poorly understood.	Lysine	13-16	CF transmembrane conductance regulator	Homo sapiens	79-83
7694154-2	1993	Mutations at Lys 335 and Arg 347 in the sixth predicted transmembrane helix of CFTR alter its halide selectivity in whole-cell studies and its single channel conductance, but the physical basis of these alterations is unknown and permeation in CFTR is poorly understood.	Lysine	13-16	CF transmembrane conductance regulator	Homo sapiens	244-248
8130075-2	1993	Addition of poly-L-lysine allowed for the stoichiometric tyrosyl phosphorylation of calmodulin in a dose-dependent fashion (EC50 approximately 83 nM) with the single target residue identified at tyr99.	Lysine	12-25	calmodulin 1	Homo sapiens	84-94
8130075-3	1993	Higher concentrations of poly-L-lysine elicited the dose-dependent inhibition of calmodulin phosphorylation (IC50 approximately 0.7 microM) by a process which did not apparently involve either stimulation of calmodulin phosphatase activity or diminished receptor kinase activity.	Lysine	25-38	calmodulin 1	Homo sapiens	81-91
8130075-3	1993	Higher concentrations of poly-L-lysine elicited the dose-dependent inhibition of calmodulin phosphorylation (IC50 approximately 0.7 microM) by a process which did not apparently involve either stimulation of calmodulin phosphatase activity or diminished receptor kinase activity.	Lysine	25-38	calmodulin 1	Homo sapiens	208-218
8130075-6	1993	Reduction in the chain length of poly-L-lysine species attenuated their ability to promote calmodulin phosphorylation with L-lysine proving to be ineffective.	Lysine	33-46	calmodulin 1	Homo sapiens	91-101
8130075-6	1993	Reduction in the chain length of poly-L-lysine species attenuated their ability to promote calmodulin phosphorylation with L-lysine proving to be ineffective.	Lysine	38-46	calmodulin 1	Homo sapiens	91-101
8130075-7	1993	Optimal promotion of calmodulin phosphorylation was achieved at an apparently constant ratio of calmodulin to poly-L-lysine of approximately 1:4 over a 100-fold range of calmodulin concentrations.	Lysine	110-123	calmodulin 1	Homo sapiens	21-31
8130075-8	1993	Poly-L-lysine promoted the precipitation and subsequent resolubilization of calmodulin in a fashion whose biphasic dose-dependence paralleled that seen for its action in promoting calmodulin"s phosphorylation.	Lysine	0-13	calmodulin 1	Homo sapiens	76-86
8130075-8	1993	Poly-L-lysine promoted the precipitation and subsequent resolubilization of calmodulin in a fashion whose biphasic dose-dependence paralleled that seen for its action in promoting calmodulin"s phosphorylation.	Lysine	0-13	calmodulin 1	Homo sapiens	180-190
8130075-9	1993	NaCl attenuated, in apparently identical dose-dependent fashions, poly-L-lysine"s ability to both elicit the precipitation of calmodulin and to promote its phosphorylation.	Lysine	66-79	calmodulin 1	Homo sapiens	126-136
8130075-10	1993	The presence of added Ca2+ led to a small potentiation of poly-L-lysine-dependent calmodulin phosphorylation at low concentrations, with inhibition occurring at higher concentrations where Ca2+ was shown to block calmodulin precipitation by poly-L-lysine.	Lysine	58-71	calmodulin 1	Homo sapiens	82-92
8130075-10	1993	The presence of added Ca2+ led to a small potentiation of poly-L-lysine-dependent calmodulin phosphorylation at low concentrations, with inhibition occurring at higher concentrations where Ca2+ was shown to block calmodulin precipitation by poly-L-lysine.	Lysine	58-71	calmodulin 1	Homo sapiens	213-223
8130075-10	1993	The presence of added Ca2+ led to a small potentiation of poly-L-lysine-dependent calmodulin phosphorylation at low concentrations, with inhibition occurring at higher concentrations where Ca2+ was shown to block calmodulin precipitation by poly-L-lysine.	Lysine	241-254	calmodulin 1	Homo sapiens	82-92
8130075-10	1993	The presence of added Ca2+ led to a small potentiation of poly-L-lysine-dependent calmodulin phosphorylation at low concentrations, with inhibition occurring at higher concentrations where Ca2+ was shown to block calmodulin precipitation by poly-L-lysine.	Lysine	241-254	calmodulin 1	Homo sapiens	213-223
8114758-4	1993	To test whether the positively charged lysine residues, and thus an amphiphilic helix, in the carboxyl terminal region of the rat LHR (rLHR) are indeed important in the activation of Gs by the rLHR, a mutant rLHR was constructed in which lysines 541, 544, and 557 were simultaneously substituted with alanines.	Lysine	39-45	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	130-133
8284112-4	1993	Both normal MCAD cDNA and a mutant MCAD cDNA containing the common, disease-causing A to G transition at position 985 (A985G), which alters a lysine to a glutamic acid (K304E), were inserted into expression vectors.	Lysine	142-148	acyl-CoA dehydrogenase medium chain	Homo sapiens	35-39
8407909-7	1993	Results indicated that B chain Lys-21 and Lys-65, both located within the anion-binding exosite, are situated within or in close proximity to the aptamer-binding site of human alpha-thrombin.	Lysine	31-34	coagulation factor II, thrombin	Homo sapiens	182-190
7692962-4	1993	Following limited digestion with trypsin, the 14-kDa SH2 domains of Src and PI 3-kinase p85 were split at a lysine within the flexible, phosphotyrosine-binding (BC) loop into 5- and 9-kDa fragments.	Lysine	108-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
8407909-7	1993	Results indicated that B chain Lys-21 and Lys-65, both located within the anion-binding exosite, are situated within or in close proximity to the aptamer-binding site of human alpha-thrombin.	Lysine	42-45	coagulation factor II, thrombin	Homo sapiens	182-190
8407909-4	1993	To identify lysine residues of thrombin that participated in the binding of the thrombin aptamer, thrombin was modified with fluorescein 5"-isothiocyanate in the presence or absence of the thrombin aptamer, reduced, carboxymethylated, and digested with endoproteinase Arg-C.	Lysine	12-18	coagulation factor II, thrombin	Homo sapiens	31-39
8407909-4	1993	To identify lysine residues of thrombin that participated in the binding of the thrombin aptamer, thrombin was modified with fluorescein 5"-isothiocyanate in the presence or absence of the thrombin aptamer, reduced, carboxymethylated, and digested with endoproteinase Arg-C.	Lysine	12-18	coagulation factor II, thrombin	Homo sapiens	80-88
8292717-6	1993	Since such a mutation constitutes a new plasmin cleavage site as first reported for fibrinogen Kyoto I, it may modify interactions of plasminogen and t-PA with carboxy-terminal lysine residues.	Lysine	177-183	plasminogen activator, tissue type	Homo sapiens	150-154
8407909-4	1993	To identify lysine residues of thrombin that participated in the binding of the thrombin aptamer, thrombin was modified with fluorescein 5"-isothiocyanate in the presence or absence of the thrombin aptamer, reduced, carboxymethylated, and digested with endoproteinase Arg-C.	Lysine	12-18	coagulation factor II, thrombin	Homo sapiens	80-88
8407909-4	1993	To identify lysine residues of thrombin that participated in the binding of the thrombin aptamer, thrombin was modified with fluorescein 5"-isothiocyanate in the presence or absence of the thrombin aptamer, reduced, carboxymethylated, and digested with endoproteinase Arg-C.	Lysine	12-18	coagulation factor II, thrombin	Homo sapiens	80-88
8239271-3	1993	The major secretase cleavage (site I) takes place between A beta 16 and 17, while the minor cleavage (site II) takes place after A beta Lys 28 and may produce potentially amyloidogenic secreted APP.	Lysine	136-139	amyloid beta precursor protein	Homo sapiens	129-135
8375390-1	1993	A porcine pancreatic phospholipase A2 mutant was constructed in which all nine lysines were replaced by arginines.	Lysine	79-86	phospholipase A2 group IB	Homo sapiens	21-37
8360181-6	1993	Solution phase fibronectin binding to immobilized plasminogen was mediated primarily via lysine binding site-dependent interactions with plasminogen kringles 1-4.	Lysine	89-95	fibronectin 1	Homo sapiens	15-26
8375390-0	1993	Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule.	Lysine	148-154	phospholipase A2 group IB	Homo sapiens	32-48
8395505-0	1993	Introduction of lysine and clot binding properties in the kringle one domain of tissue-type plasminogen activator.	Lysine	16-22	plasminogen activator, tissue type	Homo sapiens	80-113
8358734-10	1993	The neurofibromatosis 1 (NF1) gene is frequently abnormal in another neural disorder, neurofibromatosis type 1; in addition, a potential mutational hot spot of NF1 at lysine at codon 1423 has been identified in several types of tumors.	Lysine	167-173	neurofibromin 1	Homo sapiens	4-23
8358734-10	1993	The neurofibromatosis 1 (NF1) gene is frequently abnormal in another neural disorder, neurofibromatosis type 1; in addition, a potential mutational hot spot of NF1 at lysine at codon 1423 has been identified in several types of tumors.	Lysine	167-173	neurofibromin 1	Homo sapiens	25-28
8358734-10	1993	The neurofibromatosis 1 (NF1) gene is frequently abnormal in another neural disorder, neurofibromatosis type 1; in addition, a potential mutational hot spot of NF1 at lysine at codon 1423 has been identified in several types of tumors.	Lysine	167-173	neurofibromin 1	Homo sapiens	86-110
8358734-10	1993	The neurofibromatosis 1 (NF1) gene is frequently abnormal in another neural disorder, neurofibromatosis type 1; in addition, a potential mutational hot spot of NF1 at lysine at codon 1423 has been identified in several types of tumors.	Lysine	167-173	neurofibromin 1	Homo sapiens	160-163
8375393-6	1993	Binding of t-PA to carboxy-terminal lysine residues of degraded fibrin was shown to be efficiently competed by physiological concentrations of plasminogen (2 microM), indicating that the affinity of t-PA for these residues was lower than that of plasminogen (Kd = 0.66 +/- 0.22 microM) and unrelated to the high affinity of t-PA for specific binding sites on intact fibrin.	Lysine	36-42	plasminogen activator, tissue type	Homo sapiens	11-15
8375393-6	1993	Binding of t-PA to carboxy-terminal lysine residues of degraded fibrin was shown to be efficiently competed by physiological concentrations of plasminogen (2 microM), indicating that the affinity of t-PA for these residues was lower than that of plasminogen (Kd = 0.66 +/- 0.22 microM) and unrelated to the high affinity of t-PA for specific binding sites on intact fibrin.	Lysine	36-42	plasminogen activator, tissue type	Homo sapiens	199-203
8375393-6	1993	Binding of t-PA to carboxy-terminal lysine residues of degraded fibrin was shown to be efficiently competed by physiological concentrations of plasminogen (2 microM), indicating that the affinity of t-PA for these residues was lower than that of plasminogen (Kd = 0.66 +/- 0.22 microM) and unrelated to the high affinity of t-PA for specific binding sites on intact fibrin.	Lysine	36-42	plasminogen activator, tissue type	Homo sapiens	199-203
8376962-3	1993	By restriction enzyme analysis and sequencing of HDAg-coding region cDNA clones, we found that this HDV isolate bears a novel mutation (T to A) at nucleotide 1013 which converts the amber stop codon (TAG) to a codon for lysine (AAG).	Lysine	220-226	delta antigen	Hepatitis delta virus	49-53
8344413-4	1993	Cathepsin B prefers large hydrophobic residues in the P1" position of a substrate while cathepsin L has an opposite trend, favoring amino acids with small (Ala, Ser) or long but non-branched (Asn, Gln, Lys) side chains.	Lysine	202-205	cathepsin L	Homo sapiens	88-99
8186718-0	1993	Merrf family with 8344 mutation in tRNA (lys).	Lysine	41-44	mitochondrially encoded tRNA glycine	Homo sapiens	35-39
8284256-3	1993	The primary structure of the peptide (pGlu-Leu-His-Val-Asn-Lys-Ala-Arg-Arg-Pro-Tyr-Ile-Leu) is identical to that of chicken neurotensin.	Lysine	59-62	neurotensin	Gallus gallus	124-135
8344203-6	1993	The native proinsulin structure was B-chain-Arg-Arg-C-peptide-Lys-Arg-A-chain.	Lysine	62-65	insulin	Homo sapiens	11-21
8323289-0	1993	Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.	Lysine	8-14	cytochrome p450 oxidoreductase	Homo sapiens	106-137
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Lysine	187-190	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Lysine	213-216	insulin	Homo sapiens	20-30
8401214-6	1993	In this regard, similar results were obtained for a 17-residue synthetic peptide, peptide H1, which corresponds to an N-terminal region of mIL-6 (residues Val-27-Lys-43).	Lysine	162-165	interleukin 6	Mus musculus	139-144
8340428-5	1993	This enzyme also cleaved the N,N"-diacetylchitobiose moiety of the sugar chain of human transferrin tetraglycopeptide Asn-Tyr-Asn(GlcNAc)2(Man)3(GlcNAc)2(Gal)2-Lys to yield equimolar amounts of peptide Asn-Tyr-Asn(GlcNAc)Lys and sugar chain (Gal)2(GlcNAc)2(Man)3(GlcNAc).	Lysine	160-163	transferrin	Homo sapiens	88-99
7763945-2	1993	The enzyme showed a high affinity toward the Pro-X (X = Gln, Lys, Leu or Arg) bonds of substance P, dynorphin A (1-13), neurotensin and chicken brain pentapeptide, and the R-R bonds in dynorphin A and neurotensin.	Lysine	61-64	neurotensin	Gallus gallus	120-131
7763945-2	1993	The enzyme showed a high affinity toward the Pro-X (X = Gln, Lys, Leu or Arg) bonds of substance P, dynorphin A (1-13), neurotensin and chicken brain pentapeptide, and the R-R bonds in dynorphin A and neurotensin.	Lysine	61-64	neurotensin	Gallus gallus	201-212
8101305-2	1993	We report a severely insulin resistant newborn baby, the offspring of consainguineous parents, who was homozygous for a nonsense mutation (Lys 121-Amber) in this gene.	Lysine	139-142	insulin	Homo sapiens	21-28
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Lysine	78-84	cytochrome p450 oxidoreductase	Homo sapiens	154-185
8323289-9	1993	These results support the hypothesis of a predominant role of lysine residues of P450 in the electrostatic interaction with NADPH-cytochrome P450 reductase.	Lysine	62-68	cytochrome p450 oxidoreductase	Homo sapiens	124-155
8408173-3	1993	Ten patients with symmetric injuries were treated with intravenous triglycyl-lysine-vasopressin after excision of half of their burn wound.	Lysine	77-83	arginine vasopressin	Homo sapiens	84-95
8407882-8	1993	The reaction between cytochrome aco3 and eucaryotic cytochromes c was completely inhibited by poly-L-lysine.	Lysine	94-107	iron responsive element binding protein 2	Homo sapiens	32-36
8407882-9	1993	In contrast, poly-L-lysine was indispensable for sufficient reaction between the oxidase and Bacillus YN-2000 cytochrome c-553, the physiological electron donor.	Lysine	13-26	cytochrome c, somatic	Homo sapiens	110-122
8370641-1	1993	Reaction of ovine prolactin (oPRL) with a 150-fold molar excess of N-acetylimidazole over protein content resulted in the modification of 2.5 tyrosine residues and 1.2 lysine residues.	Lysine	168-174	prolactin	Homo sapiens	18-27
8505330-3	1993	We demonstrate that the in-frame deletion of 60 amino acids, from Asn204 to Glu263 in DAB389-IL-2, results in complete loss of cytotoxic activity, whereas when the amphipathic regions from Asp208 to Ser220 and Ala244 to His258 are replaced with idealized amphipathic helices composed of repeating Glu, Lys, and Leu residues, the mutant fusion toxin has low but detectable activity.	Lysine	302-305	interleukin 2	Homo sapiens	93-97
7920995-2	1993	Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied.	Lysine	66-69	growth hormone 1	Homo sapiens	16-18
8315224-3	1993	We investigated whether oral arginine/lysine could be used to increase basal IGF-I and GH levels in non-obese old men (age 69 +/- 5 years; mean +/- SD) to values similar to those of untreated young men (age 26 +/- 4 years).	Lysine	38-44	insulin like growth factor 1	Homo sapiens	77-82
8315224-3	1993	We investigated whether oral arginine/lysine could be used to increase basal IGF-I and GH levels in non-obese old men (age 69 +/- 5 years; mean +/- SD) to values similar to those of untreated young men (age 26 +/- 4 years).	Lysine	38-44	growth hormone 1	Homo sapiens	87-89
8315224-9	1993	The correlation (p &lt; .005) between measured increments in serum arginine and increases in serum GH after a single dose of arginine/lysine was similar in old and young groups.	Lysine	134-140	growth hormone 1	Homo sapiens	99-101
8371068-4	1993	Increases in electrophoretic mobility and blockage of exposed lysine residues on apoB were approximately additive for LDL modified at pH 7.4 with 6 mM HNE and MDA up to 20 mM compared to LDL modified individually with HNE or individually with MDA.	Lysine	62-68	apolipoprotein B	Homo sapiens	81-85
8321021-2	1993	In these cases, Lys 1423 in the GTPase-activating protein (GAP)-related domain of NF1 is substituted which causes a significant reduction of intrinsic GAP activity.	Lysine	16-19	neurofibromin 1	Homo sapiens	82-85
8415574-1	1993	Thrombin displays remarkable specificity, effecting the removal of fibrinopeptides A and B of fibrinogen through the selective cleavage of two Arg-Gly bonds between the 181 Arg/Lys-Xaa bonds in fibrinogen.	Lysine	177-180	coagulation factor II, thrombin	Homo sapiens	0-8
8099582-8	1993	Taking all the data together it can be concluded that both pp-vWF and laminin have glutamine and lysine residues responsive to FXIIIa and make copolymers by virtue of FXIIIa.	Lysine	97-103	von Willebrand factor	Homo sapiens	62-65
8486721-4	1993	In the present report, we have extensively dissected this subfragment of the propeptide and found that the pentapeptide Lys-Thr-Thr-Lys-Ser (residues 212-216) is the minimum sequence necessary for potent stimulation of collagen and fibronectin production in a variety of mesenchymal cells.	Lysine	120-123	fibronectin 1	Homo sapiens	232-243
8373732-3	1993	Recently, we identified three NH2-terminal lysine residues, crucial for pp60v-src membrane association.	Lysine	43-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-81
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Lysine	33-36	vasoactive intestinal peptide	Rattus norvegicus	18-21
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Lysine	33-36	vasoactive intestinal peptide	Rattus norvegicus	53-56
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Lysine	33-36	vasoactive intestinal peptide	Rattus norvegicus	53-56
8098040-2	1993	Using site-directed mutagenesis, it is shown that replacement of the absolutely conserved amino acid residue Lys-3 by arginine or isoleucine destabilizes the GroEL particle and that the replacement Lys-3--&gt;Glu completely blocks its formation.	Lysine	109-112	GroEL	Escherichia coli	158-163
8387813-3	1993	The latter is a highly electropositive surface near the C-terminal helix of thrombin abundant in arginine and lysine residues.	Lysine	110-116	coagulation factor II, thrombin	Homo sapiens	76-84
8486721-4	1993	In the present report, we have extensively dissected this subfragment of the propeptide and found that the pentapeptide Lys-Thr-Thr-Lys-Ser (residues 212-216) is the minimum sequence necessary for potent stimulation of collagen and fibronectin production in a variety of mesenchymal cells.	Lysine	132-135	fibronectin 1	Homo sapiens	232-243
8387813-9	1993	Lys35 is located on a turn of the helix, which causes it to project into solvent space in the fragment 2-thrombin complex, thereby devastating any vestige of the cationic center of the lysine binding site.	Lysine	185-191	coagulation factor II, thrombin	Homo sapiens	105-113
8332551-5	1993	In addition, the gamma-MSH sequence, contrary to salmon POMC, is present and contains three substitutions, namely a Ser, an Asn, and a Lys residue substituting the normally occurring mammalian Gly, Asp, and Arg residue, respectively.	Lysine	135-138	proopiomelanocortin	Homo sapiens	17-26
8318457-4	1993	A mutant IL-2 molecule, Lys-20 IL-2 which is known to be defective of p75 interaction, was unable to stimulate cells expressing only p75: p55 co-expression could restore its activity.	Lysine	24-27	interleukin 2	Homo sapiens	9-13
8318457-4	1993	A mutant IL-2 molecule, Lys-20 IL-2 which is known to be defective of p75 interaction, was unable to stimulate cells expressing only p75: p55 co-expression could restore its activity.	Lysine	24-27	interleukin 2	Homo sapiens	31-35
8318457-5	1993	Under conditions of low p75 expression, Lys-20 IL-2 could act as an antagonist of wild-type IL-2 action.	Lysine	40-43	interleukin 2	Homo sapiens	47-51
8318457-5	1993	Under conditions of low p75 expression, Lys-20 IL-2 could act as an antagonist of wild-type IL-2 action.	Lysine	40-43	interleukin 2	Homo sapiens	92-96
8473297-3	1993	Non-conservative mutations of Lys-893 (K893I) and Asp-993 (D993A) completely inactivate human PARP, whereas conservative and nonconservative mutations of Asp-914 (D914E and D914A, respectively) and Lys-953 (K953R and K953I, respectively) partially alter PARP activity.	Lysine	30-33	poly(ADP-ribose) polymerase 1	Homo sapiens	94-98
7690980-1	1993	The insertion of two lysine residues (cleavage sites of cathepsin B) at the boundary of a peptide recognized by B cells (BD) and a class-II- presentable sequence (TDh) enhanced the anti-BD antibody induction capacity of this type of peptide construct, as well as production of IL2.	Lysine	21-27	interleukin 2	Homo sapiens	277-280
8473297-4	1993	The consequences of conservative substitution of Lys-893 and Asp-993 on the kinetic properties of human poly(ADP-ribose) polymerase enzyme and the polymer it synthesizes suggest that these 2 amino acids are directly involved in the covalent attachment of the first ADP-ribosyl residue from NAD+ onto the acceptor amino acid.	Lysine	49-52	poly(ADP-ribose) polymerase 1	Homo sapiens	104-131
8467951-2	1993	To investigate whether a direct protein-protein interaction between apoA-I and lecithin:cholesterol acyltransferase (LCAT) is necessary for the activation of the enzyme, apoA-I was labelled with N-methylisatoic anhydride at lysine residues.	Lysine	224-230	apolipoprotein A1	Homo sapiens	68-74
8469290-3	1993	A wealth of biochemical data is available for rhodopsin: 11-cis retinal is bound to lysine 296 in helix VII; glutamic acid 113 on helix III is the counterion to the protonated Schiff"s base; a disulphide bridge, cystine 110-187, connects helix III to the second extracellular loop e2 (refs 13, 14); the carboxy terminus has two palmitoylated cysteines forming a cytoplasmic loop i4 (ref.	Lysine	84-90	rhodopsin	Homo sapiens	46-55
8477720-2	1993	Sorbitol dehydrogenase is more sensitive to proteolysis than alcohol dehydrogenase, but both enzymes show limited cleavage with Lys-specific and Glu-specific proteases.	Lysine	128-131	sorbitol dehydrogenase	Homo sapiens	0-22
8477720-3	1993	With the former, the major cleavage in both proteins involves Lys-Lys-Pro segments, at positions 247-248 in alcohol dehydrogenase, surface-positioned after the most distal beta-strand in the coenzyme-binding domain, and at 61-62 in sorbitol dehydrogenase, at another surface in the catalytic domain.	Lysine	62-65	sorbitol dehydrogenase	Homo sapiens	232-254
8477720-3	1993	With the former, the major cleavage in both proteins involves Lys-Lys-Pro segments, at positions 247-248 in alcohol dehydrogenase, surface-positioned after the most distal beta-strand in the coenzyme-binding domain, and at 61-62 in sorbitol dehydrogenase, at another surface in the catalytic domain.	Lysine	66-69	sorbitol dehydrogenase	Homo sapiens	232-254
8463515-7	1993	The BEC were inversely related to liver alcohol dehydrogenase (ADH) activities which were significantly lower in WG, LS and CS groups than in the NS group.	Lysine	117-119	aldo-keto reductase family 1 member A1	Rattus norvegicus	63-66
8454345-1	1993	Most strains of group B streptococci (GBS) elaborate a cell surface-associated enzyme that rapidly inactivates the human complement-derived chemoattractants C5a and C5adesarg by cleaving the His-Lys bond at positions 67 and 68 in the C5a molecule.	Lysine	195-198	complement C5a receptor 1	Homo sapiens	157-160
8454345-1	1993	Most strains of group B streptococci (GBS) elaborate a cell surface-associated enzyme that rapidly inactivates the human complement-derived chemoattractants C5a and C5adesarg by cleaving the His-Lys bond at positions 67 and 68 in the C5a molecule.	Lysine	195-198	complement C5a receptor 1	Homo sapiens	165-168
8388368-6	1993	When the side-chain of Lys at the 11-position was not protected, alpha-MSH was obtained only in 35% yield, and was contaminated with products of secondary hydrolysis.	Lysine	23-26	proopiomelanocortin	Homo sapiens	65-74
8466482-2	1993	A transition (G to A) was identified at codon 497 of EGFR cDNA, resulting in the substitution of a lysine for an arginine.	Lysine	99-105	epidermal growth factor receptor	Homo sapiens	53-57
7679724-2	1993	In the present study, a peptide fragment of beta A4 (beta A4 25-35; Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2), which contains the conserved C-terminal sequence of substance P (X-Gly-Leu-Met-NH2), and the neuropeptide substance P (SP) were examined for their ability to modulate nicotine-evoked secretion from cultured bovine adrenal chromaffin cells.	Lysine	80-83	tachykinin precursor 1	Bos taurus	170-181
8466542-13	1993	Studies in the intact organ and in purified liver lysosomal lysates indicate that after internalization of Nap20-HSA the conjugate is proteolytically degraded leading to the formation of the lysine conjugate of Nap.	Lysine	191-197	albumin	Homo sapiens	113-116
8463155-12	1993	Increasing lysine level resulted in increased BWT of the femur and decreased ash content of rib, femur, and metacarpal (linear, P &lt; .10).	Lysine	11-17	BONEWT	Sus scrofa	46-49
8501135-3	1993	Elution of tPA from the cell layers indicated that polylysine (5 micrograms/ml) and tranexamic acid (10 mM), an analog of lysine, were the most efficient agents for disrupting the interaction between tPA and cell surface component(s).	Lysine	55-61	plasminogen activator, tissue type	Homo sapiens	11-14
8501135-3	1993	Elution of tPA from the cell layers indicated that polylysine (5 micrograms/ml) and tranexamic acid (10 mM), an analog of lysine, were the most efficient agents for disrupting the interaction between tPA and cell surface component(s).	Lysine	55-61	plasminogen activator, tissue type	Homo sapiens	200-203
7679724-2	1993	In the present study, a peptide fragment of beta A4 (beta A4 25-35; Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2), which contains the conserved C-terminal sequence of substance P (X-Gly-Leu-Met-NH2), and the neuropeptide substance P (SP) were examined for their ability to modulate nicotine-evoked secretion from cultured bovine adrenal chromaffin cells.	Lysine	80-83	tachykinin precursor 1	Bos taurus	224-235
8483792-3	1993	Peptides to which the sequence of Arg-Gly-Asp-Val (RGDV) had been added at the carboxy-terminus of (Lys-Arg)n, Lysn, or Argn also inhibited vWF binding.	Lysine	100-103	von Willebrand factor	Homo sapiens	140-143
8483792-5	1993	These findings indicate that the general formulae (Lys-Arg)n, Lysn, and Argn with an RGDV sequence inhibit the binding of fibrinogen to activated platelets as well as the binding of vWF to GPIb.	Lysine	51-54	von Willebrand factor	Homo sapiens	182-185
8429005-2	1993	We have employed site-directed mutagenesis to dissect one of the proposed heparin binding domains of avian LPL, which contains the sequence Arg-Lys-Asn-Arg (amino acids 281-284).	Lysine	144-147	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	107-110
7679099-8	1993	These effects were severely decreased in clones expressing human IGF-I receptors in which the lysine residue in the ATP-binding site of the tyrosine kinase domain had been mutated to alanine or arginine.	Lysine	94-100	insulin like growth factor 1	Homo sapiens	65-70
8488752-3	1993	Aminopeptidase activities were studied by measuring the rate of hydrolysis of the artificial substrates Lys-, Arg-, Asp- and Tyr-2-naphthylamides (fluorimetrically detected in triplicate).	Lysine	104-107	carboxypeptidase Q	Homo sapiens	0-14
8437136-1	1993	The putative D2 dopamine receptor agonist quinpirole (LY 171,555) has been extensively used in a variety of in vivo and in vitro studies of D2 receptor-mediated effects and may have even higher affinity for the recently described D3 dopamine receptor.	Lysine	54-56	dopamine receptor D3	Rattus norvegicus	230-250
8148156-1	1993	Residues 27-31 (Lys-Asp-Pro-Lys-Arg) of the 155-amino acid form of basic fibroblast growth factor (bFGF) are in good agreement with a consensus sequence for nuclear translocation.	Lysine	16-19	fibroblast growth factor 2	Homo sapiens	67-97
8380333-0	1993	Destabilizing effects of replacing a surface lysine of cytochrome c with aromatic amino acids: implications for the denatured state.	Lysine	45-51	cytochrome c, somatic	Homo sapiens	55-67
8380333-1	1993	A series of mutations at the highly solvent-exposed lysine 73 of iso-1-cytochrome c have been prepared by site-directed mutagenesis.	Lysine	52-58	cytochrome c, somatic	Homo sapiens	71-83
8116491-11	1993	Milk protein concentration may be improved by various combinations of ruminally protected methionine and lysine if these amino acids are limiting in the diet.	Lysine	105-111	Weaning weight-maternal milk	Bos taurus	0-4
8405571-7	1993	All the mentioned proteins were protected from losing their biological functions by excess of specific amino acids with affinity to hypochlorite: Alpha-1 antiproteinase by excess of N-acetylmethionine, lysozyme by N-acetylmethionine and N-acetyl glycyltryptophane, albumin by N-acetyl derivatives of methionine, cysteine, tryptophane and lysine, whereas ribonuclease was protected from denaturation by all above mentioned amino acid derivatives.	Lysine	338-344	serpin family A member 1	Homo sapiens	146-168
8416959-8	1993	The kinetic data obtained reveals that Kex1p preferentially cleaves the COOH-terminal arginine of peptides over the COOH-terminal lysine.	Lysine	130-136	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	39-44
8416959-9	1993	Insect-derived Kex1p processes alpha-factor-Lys-Arg, its known natural substrate, to mature active alpha-factor, and this maturation event takes place in a sequential manner.	Lysine	44-47	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	15-20
8148156-1	1993	Residues 27-31 (Lys-Asp-Pro-Lys-Arg) of the 155-amino acid form of basic fibroblast growth factor (bFGF) are in good agreement with a consensus sequence for nuclear translocation.	Lysine	16-19	fibroblast growth factor 2	Homo sapiens	99-103
8148156-2	1993	To evaluate the role of this sequence in mediating the intracellular localization and biological activity of bFGF, basic residues Lys-27, Lys-30, and Arg-31 were changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	130-133	fibroblast growth factor 2	Homo sapiens	109-113
8148156-2	1993	To evaluate the role of this sequence in mediating the intracellular localization and biological activity of bFGF, basic residues Lys-27, Lys-30, and Arg-31 were changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	138-141	fibroblast growth factor 2	Homo sapiens	109-113
1472504-11	1992	The tertiary structure of the alpha-chain induces a considerable degree of catalytic activity to the microenvironment of Lys-16(alpha) to isomerize the aldimine adduct at this site.	Lysine	121-124	Fc gamma receptor and transporter	Homo sapiens	30-41
8100980-2	1993	In this study, we found that low concentrations of the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY) stimulate PRL secretion in female rats, assessed by reverse hemolytic plaque assay.	Lysine	121-123	prolactin	Rattus norvegicus	135-138
8100980-6	1993	Low concentrations of LY (10(-12), 10(-10) M) with TRH (10(-7) M) produced an additive effect on TRH-induced PRL release.	Lysine	22-24	prolactin	Rattus norvegicus	109-112
8387235-4	1993	By inspection of the three-dimensional structure of the portion of the PPAR ligand-binding domain, a putative binding site for peroxisome proliferators, consisting of one isoleucine, one lysine and two phenylalanine moieties (residues 354, 358, 359 and 361, respectively), has been identified.	Lysine	187-193	peroxisome proliferator activated receptor alpha	Mus musculus	71-75
1464597-11	1992	The titration behavior of apoA-I Lys residues is the same in small and large spherical particles, indicating that apoA-I conformation is similar on the two particles.	Lysine	33-36	apolipoprotein A1	Homo sapiens	26-32
1283743-3	1992	As a result of this study a series of low-energy conformations were identified showing a common folding pattern with residues Val-3, Pro-4, His-5 and Lys-6 forming a beta turn.	Lysine	150-153	amyloid beta precursor protein	Homo sapiens	164-170
1460031-10	1992	We conclude that the residues Lys-57, Arg-58, and Trp-67 contribute to the structure of the PCh-binding site of human CRP.	Lysine	30-33	C-reactive protein	Homo sapiens	118-121
1493798-4	1992	Chemical modification of lysine and arginine residues of TSP, but not treatment of the molecule with neuraminidase, resulted in a pronounced loss of binding at the cell surface.	Lysine	25-31	thrombospondin 1	Homo sapiens	57-60
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Lysine	205-208	complement C5a receptor 1	Homo sapiens	40-43
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Lysine	205-208	complement C5a receptor 1	Homo sapiens	151-154
1452354-1	1992	Compositional analysis of streptococcal C5a peptidase (SCPA) cleavage products from a synthetic peptide corresponding to the 20 C-terminal residues of C5a demonstrated that the target cleavage site is His-Lys rather than Lys-Asp, as previously suggested.	Lysine	221-224	complement C5a receptor 1	Homo sapiens	151-154
1452354-2	1992	A C5a peptide analog with Lys replaced by Gln was also subject to cleavage by SCPA.	Lysine	26-29	complement C5a receptor 1	Homo sapiens	2-5
1466663-5	1992	The number of reactive lysine residues in apo B was decreased by Cu-catalyzed LDL oxidation, acetylation, maleylation and by malondialdehyde conjugation.	Lysine	23-29	apolipoprotein B	Homo sapiens	42-47
1466663-14	1992	Rather it seems dependent upon the net charge of the apo B protein and probably involves the modification of critical lysine residues.	Lysine	118-124	apolipoprotein B	Homo sapiens	53-58
1335425-2	1992	However the surface potential is slightly decreased (approximately 3 mV) when PLP(Lys 86)-cytochrome c and PLP(Lys 79)-cytochrome c were added.	Lysine	82-85	cytochrome c, somatic	Homo sapiens	90-102
1335425-2	1992	However the surface potential is slightly decreased (approximately 3 mV) when PLP(Lys 86)-cytochrome c and PLP(Lys 79)-cytochrome c were added.	Lysine	111-114	cytochrome c, somatic	Homo sapiens	119-131
1416988-11	1992	Therefore, under optimized in vitro conditions, the substrate recognition sequence for Pim-1 kinase is (Arg/Lys)3-X-Ser/Thr*-X", where X" is likely neither a basic nor a large hydrophobic residue.	Lysine	108-111	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	87-92
1362901-7	1992	Interestingly, replacement of Glu63 of c-HaRas by Lys reduces its intrinsic GTPase activity and abolishes the GTPase activation by both NF1C and GAP1C.	Lysine	50-53	nuclear factor I C	Homo sapiens	136-140
1360025-4	1992	When Lys(Ac) was substituted for Arg9, kappa opioid receptor affinity was enhanced and kappa receptor selectivity was retained.	Lysine	5-8	kappa-type opioid receptor	Cavia porcellus	39-60
1343568-3	1992	In this study, we investigate the effect of lysine modification on calmodulin function.	Lysine	44-50	calmodulin 1	Homo sapiens	67-77
1343568-4	1992	Azidosalicylate reagents containing different "linker arm" lengths, between the photoactive terminus and an amine-reactive N-hydroxysuccinimidyl ester moiety were used to modify calmodulin lysines at three different positions in a calcium-dependent manner.	Lysine	189-196	calmodulin 1	Homo sapiens	178-188
1466764-8	1992	These data show that the structural integrity surrounding and perhaps including the Asn-Tyr-Pro-Lys region may be crucial for the biological activity of rIL-1 beta and may be important for the binding of IL-1 to its receptor.	Lysine	96-99	interleukin 1 beta	Rattus norvegicus	153-163
1454065-14	1992	Peptides such as (EYA)2EYKEYA or EYAEYK(EYA)2 with lysine substitution in the middle of the sequence were non immunogeneic.	Lysine	51-57	EYA transcriptional coactivator and phosphatase 2	Mus musculus	18-23
1474122-5	1992	Strong peptide-peptide interactions, occurring through interchain hydrophobic forces, resulted in a presenting face to the C18 group, consisting primarily of lysine residues and, in turn, in early retention times.	Lysine	158-164	Bardet-Biedl syndrome 9	Homo sapiens	123-126
1429612-0	1992	Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorus.	Lysine	59-62	phospholipase A2 group IB	Homo sapiens	66-82
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Lysine	115-118	insulin	Homo sapiens	88-95
1406679-5	1992	Phosphorylation of the conserved serine 15 in human p53 peptides depended on the presence of an adjacent glutamine, and phosphorylation was inhibited by the presence of a nearby lysine.	Lysine	178-184	tumor protein p53	Homo sapiens	52-55
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Lysine	119-122	albumin	Homo sapiens	12-15
1391954-0	1992	Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA--&gt;stop TAA).	Lysine	97-100	fibrinogen beta chain	Homo sapiens	0-10
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Lysine	119-122	albumin	Homo sapiens	32-35
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Lysine	140-143	albumin	Homo sapiens	12-15
1417976-2	1992	The mutants Alb Milano Fast and Alb Vanves possess single amino acid substitutions close to the C-terminus, namely 573 Lys--&gt;Glu and 574 Lys--&gt;Asn, respectively.	Lysine	140-143	albumin	Homo sapiens	32-35
1328207-1	1992	A methionine aminopeptidase that specifically removes methionine residues from peptides with amino-terminal sequences of Met-Ala-, Met-Val-, Met-Ser-, Met-Gly-, and Met-Pro- but not Met-Leu- or Met-Lys- has been isolated to homogeneity from porcine liver by a procedure involving five chromatographic steps.	Lysine	198-201	aminopeptidase	Saccharomyces cerevisiae S288C	13-27
1402651-0	1992	Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.	Lysine	76-82	tumor necrosis factor	Homo sapiens	26-53
1400583-0	1992	Lysine residues form an integral component of a novel NH2-terminal membrane targeting motif for myristylated pp60v-src.	Lysine	0-6	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
1400583-3	1992	Using chimeric src proteins, peptides identical or related to the NH2 terminus of src, and site-directed mutagenesis, we demonstrate that NH2-terminal lysines in conjunction with myristate are essential for membrane localization.	Lysine	151-158	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-18
1400583-3	1992	Using chimeric src proteins, peptides identical or related to the NH2 terminus of src, and site-directed mutagenesis, we demonstrate that NH2-terminal lysines in conjunction with myristate are essential for membrane localization.	Lysine	151-158	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
1397292-1	1992	The amino acid sequence, Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1, is thought to be a consensus processing site for a constitutive secretory pathway in non-endocrine cells.	Lysine	35-38	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	39-50
1420959-5	1992	The orientation of the lysine side chains within preferential geometries of the individual templates is analyzed and a tentative evaluation for their potential to stabilize TASP molecules of 4-helix bundle topology is given.	Lysine	23-29	LanC like 2	Homo sapiens	173-177
1452413-6	1992	Peptide TTKD section (the fragment 77-80 of murine Thy-1-antigen) contained in C- and N-terminus amino acids (T and D) which stimulated the antibody production and phagocytosis, and lysine (K) which stimulated phagocytosis only, enhanced both processes.	Lysine	182-188	thymus cell antigen 1, theta	Mus musculus	51-64
1429881-2	1992	In the case of endothelin receptors, however, a lysine residue replaces this conserved aspartic acid residue.	Lysine	48-54	endothelin 1	Rattus norvegicus	15-25
1402651-6	1992	As the TNF precursor does not contain an NH2-terminal glycine, we hypothesized that myristyl acylation occurs on the N-epsilon-NH2 groups of lysine, of which two are present in the propiece (K19K20).	Lysine	141-147	tumor necrosis factor	Homo sapiens	7-10
1419804-3	1992	Sequencing identified two potential missense mutations resulting in the amino acid substitutions Arg 834--&gt;Gln and Glu 875--&gt;Lys in the mature vWF subunit within an area of vWF where mutations in type IIA vWD have been reported.	Lysine	131-134	von Willebrand factor	Homo sapiens	149-152
1333213-5	1992	In general, the nitroxide immobilization was greater for spin-labeled thrombin complexes with HV2-Lys 47 vs. HV1.	Lysine	98-101	coagulation factor II, thrombin	Homo sapiens	70-78
1333213-6	1992	The two fluorophore moieties, dansyl and anthraniloyl, were also sensitive to differences in HV1 and HV2-Lys 47 binding, including interactions with loop 145-150 of the thrombin structure where the epsilon- and zeta-thrombin cleavages exist.	Lysine	105-108	coagulation factor II, thrombin	Homo sapiens	169-177
1327110-1	1992	Fluorescein isothiocyanate derivatization of the human lactotransferrin on Lys-264 inhibits the binding of the protein of human PHA-activated lymphocytes [Legrand, D., Mazurier, J., Maes, P., Rochard, E., Montreuil, J., &amp; Spik, G. (1991) Biochem.	Lysine	75-78	lactotransferrin	Homo sapiens	55-71
1327110-8	1992	SASD, which binds to Lys-74, was able to inhibit the binding of lactotransferrin to the cell receptor, in contrast to Lys-281-binding sulfo-SANPAH.	Lysine	21-24	lactotransferrin	Homo sapiens	64-80
1326525-3	1992	N-tert-Butoxycarbonyl- (N-t-Boc) 125I-tyrosine or [35S]methionine were conjugated to the 8th amino acid of lysine- (LVP) or deamino-ornithine-vasopressin via active succinimidyl esters.	Lysine	107-114	arginine vasopressin	Homo sapiens	142-153
1356370-1	1992	Two critical amino acids in the visual pigment rhodopsin are Lys-296, the site of attachment of retinal to the protein through a protonated Schiff base linkage, and Glu-113, the Schiff base counterion.	Lysine	61-64	rhodopsin	Homo sapiens	47-56
1458057-3	1992	When ET-1 was reacted with succinimidyl-6-(biotinamido)hexanoate in an organic solvent, ET-1 was exclusively modified at lysine 9.	Lysine	121-127	endothelin 1	Homo sapiens	5-9
1458057-3	1992	When ET-1 was reacted with succinimidyl-6-(biotinamido)hexanoate in an organic solvent, ET-1 was exclusively modified at lysine 9.	Lysine	121-127	endothelin 1	Homo sapiens	88-92
1417818-2	1992	Mutation of Lys199 to Gln in the intramembrane domain strongly reduced the affinity to both [125I] Ang II and [125I]-1Sar, 8Ile-Ang II whereas mutation of two other Lys had little effect, indicating involvement of Lys199 in binding ligands.	Lysine	12-15	angiotensinogen	Rattus norvegicus	99-105
1417818-2	1992	Mutation of Lys199 to Gln in the intramembrane domain strongly reduced the affinity to both [125I] Ang II and [125I]-1Sar, 8Ile-Ang II whereas mutation of two other Lys had little effect, indicating involvement of Lys199 in binding ligands.	Lysine	12-15	angiotensinogen	Rattus norvegicus	128-134
1356443-9	1992	This substitution demonstrates that Lys-146 is essential for the binding of apo E to the receptor.	Lysine	36-39	apolipoprotein E	Homo sapiens	76-81
1326962-8	1992	The binding of 125I-t-PA to endothelial cells was reduced in the presence of an excess amount of t-PA, plasminogen and 6-aminohexanoic acid, indicating that the binding sites were also recognized by plasminogen, and that t-PA and plasminogen were bound via lysine binding sites in the molecule.	Lysine	257-263	plasminogen activator, tissue type	Homo sapiens	20-24
1326962-8	1992	The binding of 125I-t-PA to endothelial cells was reduced in the presence of an excess amount of t-PA, plasminogen and 6-aminohexanoic acid, indicating that the binding sites were also recognized by plasminogen, and that t-PA and plasminogen were bound via lysine binding sites in the molecule.	Lysine	257-263	plasminogen activator, tissue type	Homo sapiens	97-101
1326962-8	1992	The binding of 125I-t-PA to endothelial cells was reduced in the presence of an excess amount of t-PA, plasminogen and 6-aminohexanoic acid, indicating that the binding sites were also recognized by plasminogen, and that t-PA and plasminogen were bound via lysine binding sites in the molecule.	Lysine	257-263	plasminogen activator, tissue type	Homo sapiens	97-101
1525179-2	1992	We have shown that t-PA dissociates from 1-3-1 in the presence of the lysine analogue 6-aminohexanoic acid (6-AHA).	Lysine	70-76	plasminogen activator, tissue type	Homo sapiens	19-23
1419804-3	1992	Sequencing identified two potential missense mutations resulting in the amino acid substitutions Arg 834--&gt;Gln and Glu 875--&gt;Lys in the mature vWF subunit within an area of vWF where mutations in type IIA vWD have been reported.	Lysine	131-134	von Willebrand factor	Homo sapiens	179-182
1450522-2	1992	The sequence -Thr-Pro-Ala-Pro-Lys-, as found in p53 protein, was also phosphorylated by this enzyme, but less efficiently than in the sequence described above.	Lysine	30-33	tumor protein p53	Homo sapiens	48-51
1505778-8	1992	The primary glycation sites in EC-SOD are thus lysine-211 and lysine-212 in the putative heparin-binding domain in the carboxyterminal end.	Lysine	47-53	superoxide dismutase 3	Homo sapiens	31-37
1505778-8	1992	The primary glycation sites in EC-SOD are thus lysine-211 and lysine-212 in the putative heparin-binding domain in the carboxyterminal end.	Lysine	62-68	superoxide dismutase 3	Homo sapiens	31-37
1512296-15	1992	As with L1 and Ng-CAM, the two chains of Bravo are generated from an intact polypeptide by cleavage at identical locations and conserved sites within all three molecules (Ser-Arg/Lys-Arg).	Lysine	179-182	L1 cell adhesion molecule	Gallus gallus	15-21
1417919-4	1992	Chemical modification of this aminopeptidase by several amino acid-modifying agents indicated essential lysine, histidine, arginine, cysteine, and tyrosine residues.	Lysine	104-110	carboxypeptidase Q	Homo sapiens	30-44
1387328-7	1992	A comparison of the pea dehydrin sequence with sequences from other species revealed conserved amino acid regions: an N-terminal DEYGNP and a lysine-rich block (KIKEKLPG), both of which are present in two copies.	Lysine	142-148	dehydrin	Zea mays	24-32
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	84-90	superoxide dismutase 3	Homo sapiens	12-18
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	60-63	superoxide dismutase 3	Homo sapiens	12-18
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	101-104	superoxide dismutase 3	Homo sapiens	12-18
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	101-104	superoxide dismutase 3	Homo sapiens	12-18
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	139-145	superoxide dismutase 3	Homo sapiens	12-18
1637178-7	1992	Recombinant EC-SOD C treated with trypsin or endoproteinase Lys C, which lost three lysine residues (Lys-211, Lys-212, and Lys-220) or one lysine residue (Lys-220) at the C-terminal end, had no or weak affinity for the heparin HPLC column, respectively.	Lysine	101-104	superoxide dismutase 3	Homo sapiens	12-18
1637178-8	1992	The proteinase-treated r-EC-SOD C also lost triple arginine residues which are adjacent to double lysine residues.	Lysine	98-104	superoxide dismutase 3	Homo sapiens	25-31
1637178-10	1992	It appeared that the proteolytic cleavage of the exteriorized lysine- and arginine-rich C-terminal end in vivo is a more important contributory factor to the formation of EC-SOD B and/or EC-SOD A.	Lysine	62-68	superoxide dismutase 3	Homo sapiens	171-177
1637178-10	1992	It appeared that the proteolytic cleavage of the exteriorized lysine- and arginine-rich C-terminal end in vivo is a more important contributory factor to the formation of EC-SOD B and/or EC-SOD A.	Lysine	62-68	superoxide dismutase 3	Homo sapiens	187-193
1321590-0	1992	Presence of an essential lysine residue in a GDP-fucose protected site of the alpha 1----3fucosyltransferase from human small cell lung carcinoma NCl-H69 cells.	Lysine	25-31	fucosyltransferase 11	Homo sapiens	78-108
1325656-2	1992	VU-1 calmodulin, similar to endogenous plant calmodulin, possesses a lysine residue at position 115 and undergoes posttranslational methylation.	Lysine	69-75	calmodulin	Nicotiana tabacum	5-15
1325656-2	1992	VU-1 calmodulin, similar to endogenous plant calmodulin, possesses a lysine residue at position 115 and undergoes posttranslational methylation.	Lysine	69-75	calmodulin	Nicotiana tabacum	45-55
1515063-1	1992	An aminopeptidase hydrolyzing 2-naphthylamides of Lys, Arg, Leu, Met, Phe and Tyr, as well as different di- to tridecapeptides, was purified from the cytosol of human erythrocytes.	Lysine	50-53	carboxypeptidase Q	Homo sapiens	3-17
1333234-7	1992	The removal of the positive charge on any one lysine weakens the binding to cytochrome c oxidase by at least 1 kcal (1 cal = 4.1868 J).	Lysine	46-52	cytochrome c, somatic	Homo sapiens	76-88
1333234-8	1992	The presence of bimane at lysines 13 and 87 clearly forces the separation of the cytochrome c and oxidase, but this does not occur with the other complexes.	Lysine	26-33	cytochrome c, somatic	Homo sapiens	81-93
1333234-9	1992	The bimane-modified lysine-13 protein, and to a lesser extent that modified at lysine 8, show the interesting effect of enhanced complex formation with cytochrome c oxidase when subjected to pressure, possibly because of entrapment of water at the newly created interface of the complex.	Lysine	20-26	cytochrome c, somatic	Homo sapiens	152-164
1333234-9	1992	The bimane-modified lysine-13 protein, and to a lesser extent that modified at lysine 8, show the interesting effect of enhanced complex formation with cytochrome c oxidase when subjected to pressure, possibly because of entrapment of water at the newly created interface of the complex.	Lysine	79-85	cytochrome c, somatic	Homo sapiens	152-164
1353610-4	1992	The new crystal structures of human SOD show that amino-acid site chains that are implicated in electrostatic guidance (Glu 132, Glu 133 and Lys 136) form a hydrogen-bonding network.	Lysine	141-144	superoxide dismutase 1	Homo sapiens	36-39
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	32-35	catalase	Homo sapiens	188-196
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	62-65	catalase	Homo sapiens	188-196
1497755-1	1992	Light-induced H+ release and reuptake as well as surface potential changes inherent in the bacterio-rhodopsin reaction cycle were measured between 10 degrees C and 50 degrees C. Signals of optical pH indicators covalently bound to Lys-129 at the extracellular surface of bacteriorhodopsin were compared with absorbance changes of probes residing in the aqueous bulk phase.	Lysine	231-234	rhodopsin	Homo sapiens	100-109
1352391-3	1992	In Libyan Jews, CJD segregates with a point mutation at codon 200 of the PrP gene, resulting in the substitution of lysine for glutamate.	Lysine	116-122	prion protein	Homo sapiens	73-76
1391615-4	1992	In this study, covalent CS2 binding in a lysine-containing dipeptide and in bovine serum albumin (BSA) in vitro was characterized.	Lysine	41-47	chorionic somatomammotropin hormone 2	Homo sapiens	24-27
1321046-18	1992	The random polymer of Glu, Lys, Ala, Tyr (2:5:6:1), which was not phosphorylated by the EGF-R kinase, dramatically activates autophosphorylation of the EGF-R.	Lysine	27-30	epidermal growth factor receptor	Homo sapiens	152-157
1421808-8	1992	Our studies indicate that Lys-NH2 at the C-terminus of GH-RH(1-29) and/or beta-Ala, GABA (gamma-aminobutyric acid), and Phe in position 15 are disadvantageous, but potent GH-RH analogs can result from the combination of agmatine in position 29 with other substitutions.	Lysine	26-29	growth hormone releasing hormone	Homo sapiens	55-60
1421808-8	1992	Our studies indicate that Lys-NH2 at the C-terminus of GH-RH(1-29) and/or beta-Ala, GABA (gamma-aminobutyric acid), and Phe in position 15 are disadvantageous, but potent GH-RH analogs can result from the combination of agmatine in position 29 with other substitutions.	Lysine	26-29	growth hormone releasing hormone	Homo sapiens	171-176
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	24-27	fibroblast growth factor 2	Homo sapiens	146-176
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	24-27	fibroblast growth factor 2	Homo sapiens	178-182
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	33-36	fibroblast growth factor 2	Homo sapiens	146-176
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Lysine	33-36	fibroblast growth factor 2	Homo sapiens	178-182
1601889-6	1992	We hypothesize that this distribution of glutamine residues together with the elongated shape of the molecule permits optimal interaction of involucrin glutamyl side chains with the lysine residues of other para-membranous proteins during transglutaminase-mediated cross-linking.	Lysine	182-188	involucrin	Homo sapiens	141-151
1375718-3	1992	Substitution of one of these residues (Lys-280) from tsLA90src with its wild-type homolog (Glu-280) caused a reversion to a wild-type src phenotype.	Lysine	39-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-62
1394685-1	1992	Poly-L-lysine with molecular masses of 3.3-290 kDa increased the amidolytic activities of leukocyte elastase and cathepsin G at low concentration, but had little effect on the activities of pancreatic elastase, alpha-chymotrypsin, plasmin and thrombin.	Lysine	0-13	coagulation factor II, thrombin	Homo sapiens	243-251
1352271-3	1992	In the GC2 phenotype, amino acid 420 is a lysine residue, and in the both common GC1 phenotypes, it is a threonine residue.	Lysine	42-48	solute carrier family 25 member 18	Homo sapiens	7-10
1349282-0	1992	The carboxy-terminal lysine of alpha B-crystallin is an amine-donor substrate for tissue transglutaminase.	Lysine	21-27	transglutaminase 2	Homo sapiens	82-105
1568468-11	1992	These in vitro and in vivo observations strongly suggest that MDP-Lys(L18) indirectly enhances the proliferation and differentiation of mouse CFU-Meg via colony-stimulating factor(s) other than IL-1, probably as a result of the stimulation of macrophages to produce IL-6.	Lysine	66-69	interleukin 6	Mus musculus	266-270
1567199-5	1992	Since cysteine residues have been suggested to be important for the catalysis of flavoproteins and a lysine residue at position 76 in NAD(P)H:quinone oxidoreductase has been proposed to be involved in electron transfer of the enzyme, we investigated the roles of lysine 76 and cysteine 179 of this enzyme in catalysis by site-directed mutagenesis.	Lysine	101-107	crystallin zeta	Rattus norvegicus	142-164
1571548-9	1992	A conservative substitution of the P4 arginine by lysine resulted in a decrease in vWF processing by PACE, as did a nonconservative substitution to alanine.	Lysine	50-56	von Willebrand factor	Homo sapiens	83-86
1379290-1	1992	Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS).	Lysine	78-91	interferon alpha 1	Homo sapiens	0-10
1379290-1	1992	Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS).	Lysine	78-91	interferon alpha 1	Homo sapiens	12-15
1568247-3	1992	We describe an amino acid substitution in the NF1 GRD, altering Lys-1423, that has occurred in three tumor types: colon adenocarcinoma, myelodysplastic syndrome, and anaplastic astrocytoma, and in one family with neurofibromatosis 1.	Lysine	64-67	neurofibromin 1	Homo sapiens	46-49
1568247-3	1992	We describe an amino acid substitution in the NF1 GRD, altering Lys-1423, that has occurred in three tumor types: colon adenocarcinoma, myelodysplastic syndrome, and anaplastic astrocytoma, and in one family with neurofibromatosis 1.	Lysine	64-67	neurofibromin 1	Homo sapiens	213-232
1372009-1	1992	We have shown previously that a deletion mutant of human heparin-binding growth factor (HBGF)-1, HBGF-1U, lacking the sequence Asn-Tyr-Lys-Lys-Pro-Lys-Leu is capable of initiating c-fos mRNA expression and polypeptide phosphorylation on tyrosine residues at concentrations that do not induce either DNA synthesis or cell proliferation (1).	Lysine	135-138	fibroblast growth factor 1	Homo sapiens	57-95
1551909-6	1992	Electrophoretic studies confirmed that P1-Lys and P1-His can form sodium dodecyl sulfate-resistant complexes with C1s.	Lysine	42-45	complement C1s	Homo sapiens	114-117
1625324-1	1992	The effect of mutation of either Lys 558 or Lys 869 or both on mouse erythroid band 3 protein (AE1)-mediated 36Cl- efflux and its inhibition by pyridoxal 5-phosphate (P5-P), DNDS and H2DIDS were studied.	Lysine	33-36	solute carrier family 4 (anion exchanger), member 1	Mus musculus	95-98
1625324-1	1992	The effect of mutation of either Lys 558 or Lys 869 or both on mouse erythroid band 3 protein (AE1)-mediated 36Cl- efflux and its inhibition by pyridoxal 5-phosphate (P5-P), DNDS and H2DIDS were studied.	Lysine	44-47	solute carrier family 4 (anion exchanger), member 1	Mus musculus	95-98
1304352-3	1992	In the presence of Ca2+, yeast calmodulin is sequentially cleaved at arginine 126, then lysine 115, and finally at lysine 77.	Lysine	88-94	calmodulin	Saccharomyces cerevisiae S288C	31-41
1304352-3	1992	In the presence of Ca2+, yeast calmodulin is sequentially cleaved at arginine 126, then lysine 115, and finally at lysine 77.	Lysine	115-121	calmodulin	Saccharomyces cerevisiae S288C	31-41
1304352-5	1992	In the presence of EGTA, yeast calmodulin is more susceptible to proteolysis and is preferentially cleaved at Lys-106.	Lysine	110-113	calmodulin	Saccharomyces cerevisiae S288C	31-41
1304352-8	1992	Furthermore, whereas wild-type calmodulin is cut at Lys-106 only in the presence of EGTA, this cleavage site is accessible in the mutants in the presence of Ca2+ as well.	Lysine	52-55	calmodulin	Saccharomyces cerevisiae S288C	31-41
1556130-6	1992	Lastly, attachment of the specific ER retention signal KDEL (Lys-Asp-Glu-Leu) to the carboxyl terminus of LPL also resulted in intracellularly retained enzyme that was fully active.	Lysine	61-64	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	106-109
1565649-7	1992	We investigated the role of the vicinal cysteines and the lysine residue in the vWf propolypeptide by site-directed mutagenesis and expression of the resulting constructs in mammalian cells.	Lysine	58-64	von Willebrand factor	Homo sapiens	80-83
1368489-3	1992	Inactivation of L-asparaginase is associated with a single cleavage adjacent to lysine-29 that results in loss of an N-terminal fragment with a calculated MW of 2,647.	Lysine	80-86	asparaginase and isoaspartyl peptidase 1	Homo sapiens	16-30
1312009-1	1992	A soluble construct consisting of a plasmid carrying the gene of the SV40 large T-antigen and an insulin-poly-L-lysine conjugate is able to selectively transfect PLC/PRF/5 human hepatoma cells which possess insulin receptors.	Lysine	105-118	insulin	Homo sapiens	97-104
1312009-1	1992	A soluble construct consisting of a plasmid carrying the gene of the SV40 large T-antigen and an insulin-poly-L-lysine conjugate is able to selectively transfect PLC/PRF/5 human hepatoma cells which possess insulin receptors.	Lysine	105-118	insulin	Homo sapiens	207-214
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Lysine	202-208	interleukin 1 beta	Homo sapiens	18-36
1532325-2	1992	Recombinant human interleukin-1 beta (h-IL-1 beta) was chemically modified with 4-(N,N-dimethylamino)-4"-isothiocyanatoazobenzene-2"-sulfonic acid (S-DABITC), a water-soluble color reagent specific for lysine labeling.	Lysine	202-208	interleukin 1 beta	Homo sapiens	40-49
1372554-10	1992	Here we show that poly(lysine), but neither NaCl nor heparin, specifically enhances the phosphorylation efficiency of lyn TPK for the peptide EDNEYTA (src peptide).	Lysine	23-29	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	118-121
1372009-1	1992	We have shown previously that a deletion mutant of human heparin-binding growth factor (HBGF)-1, HBGF-1U, lacking the sequence Asn-Tyr-Lys-Lys-Pro-Lys-Leu is capable of initiating c-fos mRNA expression and polypeptide phosphorylation on tyrosine residues at concentrations that do not induce either DNA synthesis or cell proliferation (1).	Lysine	139-142	fibroblast growth factor 1	Homo sapiens	57-95
1309738-4	1992	This effect is not induced by poly-L-lysine, a homopolypeptide which is known to bind to the cytochrome c binding domain of cytochrome c oxidase.	Lysine	30-43	cytochrome c, somatic	Homo sapiens	93-105
1312118-2	1992	BSC40 cells lack a processing endoprotease of the neuropeptide precursor, pro-opiomelanocortin (POMC), which possesses multiple cleavage sites at pairs of basic residues, Lys-Arg and Arg-Arg, a motif similar to that found in the cleavage site of the F0 proteins.	Lysine	171-174	proopiomelanocortin	Homo sapiens	96-100
1740158-4	1992	Sequence similarity (24% identity) with mammalian glutamate decarboxylase was found to be limited to a 55-residue sequence around the lysine residue that binds the coenzyme.	Lysine	134-140	glutamate-ammonia ligase	Homo sapiens	50-73
1370824-2	1992	Site-directed mutagenesis of the 3 lysine residues of the reductase, previously implicated in the formation of active-site charge pairs with carboxylate residues of cytochrome b5, was then used to obtain the purified catalytic domains of flavoproteins modified at each of these sites.	Lysine	35-41	cytochrome b5 type A	Bos taurus	165-178
1735430-6	1992	A chimeric enzyme, made of the amino-terminal moiety of rat liver aspartyl-tRNA synthetase fused to the catalytic domain of yeast lysyl-tRNA synthetase, has been expressed in Lys-101 cells, a CHO cell line with a temperature-sensitive lysyl-tRNA synthetase.	Lysine	175-178	aspartyl-tRNA synthetase 1	Rattus norvegicus	66-90
1735430-6	1992	A chimeric enzyme, made of the amino-terminal moiety of rat liver aspartyl-tRNA synthetase fused to the catalytic domain of yeast lysyl-tRNA synthetase, has been expressed in Lys-101 cells, a CHO cell line with a temperature-sensitive lysyl-tRNA synthetase.	Lysine	175-178	lysine--tRNA ligase	Cricetulus griseus	130-151
1377415-3	1992	Stimuli used to promote secretion of prostacyclin and vWF were human alpha-thrombin, histamine, protamine sulphate, poly-L-lysine and phorbol myristate acetate.	Lysine	116-129	von Willebrand factor	Homo sapiens	54-57
1377416-0	1992	Characterization of human tissue-type plasminogen activator with monoclonal antibodies: mapping of epitopes and binding sites for fibrin and lysine.	Lysine	141-147	plasminogen activator, tissue type	Homo sapiens	26-59
1377416-10	1992	Many antibodies quench also binding of t-PA to lysine-Sepharose.	Lysine	47-53	plasminogen activator, tissue type	Homo sapiens	39-43
1543503-0	1992	Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase.	Lysine	49-52	aldo-keto reductase family 1 member B	Homo sapiens	66-82
1531337-0	1992	Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103.	Lysine	89-95	interleukin 1 beta	Homo sapiens	39-57
1531337-10	1992	Thus, Cys-8 or Lys-103 modification of rIL-1 beta by acrylodan also does not interfere with the ability of the molecule to bind to its receptor.	Lysine	15-18	interleukin 1 beta	Rattus norvegicus	39-49
1531338-1	1992	We have determined the fluorescence properties of two covalently attached acrylodan derivatives of recombinant human interleukin-1 beta, namely the Cys-8 and Lys-103 adducts.	Lysine	158-161	interleukin 1 beta	Homo sapiens	117-135
1311948-2	1992	This polymorphism gives rise to two apo B alleles, one (E+) encoding glutamic acid and the other (E-) encoding lysine at position 4,154 in apo B-100, the protein of low density lipoprotein (LDL).	Lysine	111-117	apolipoprotein B	Homo sapiens	36-41
1311948-2	1992	This polymorphism gives rise to two apo B alleles, one (E+) encoding glutamic acid and the other (E-) encoding lysine at position 4,154 in apo B-100, the protein of low density lipoprotein (LDL).	Lysine	111-117	apolipoprotein B	Homo sapiens	139-148
1310101-4	1992	The I-Ek MHC class II molecules were immunoprecipitated from B cells that had processed the model protein antigen cytochrome c radiolabeled across its entire length by reductive methylation of lysine residues and covalently coupled to Ig-specific antibodies, allowing internalization after binding to surface Ig.	Lysine	193-199	cytochrome c, somatic	Homo sapiens	114-126
1535317-9	1992	Vasopressin responses to m-CPP were entirely antagonised by the 5-HT1/5-HT2 antagonist metergoline, partially by the 5-HT2/5-HT1C antagonists ritanserin and LY 53857, but not by the 5-HT2 antagonist ketanserin.	Lysine	157-159	arginine vasopressin	Rattus norvegicus	0-11
1309738-4	1992	This effect is not induced by poly-L-lysine, a homopolypeptide which is known to bind to the cytochrome c binding domain of cytochrome c oxidase.	Lysine	30-43	cytochrome c, somatic	Homo sapiens	124-136
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Lysine	55-58	interleukin 1 beta	Homo sapiens	106-115
1309292-0	1992	Direct identification of lysine-33 as the principal cationic center of the omega-amino acid binding site of the recombinant kringle 2 domain of tissue-type plasminogen activator.	Lysine	25-31	plasminogen activator, tissue type	Homo sapiens	144-177
1732513-4	1992	Of the charged amino acids in the C"" and D strands of the amino-terminal domain of CD4, alteration of only two, lysine 46 and arginine 59, dramatically disrupted ability to bind gp120.	Lysine	113-119	CD4 molecule	Homo sapiens	84-87
1281611-1	1992	A human urine serine proteinase chymotrypsin like hydrolyzes the peptide bonds: Phe-Ser (kinin); Gly-Gly, Leu-Arg, Phe-Lys (neuropeptides) and Gln-Gln (substance P).	Lysine	119-122	tachykinin precursor 1	Homo sapiens	152-163
1585417-7	1992	of Lysine induces a significant increment of thymulin blood level both in elderly and in cancer patients and at peripheral level, an increase of CD4+ lymphocyte subpopulation.	Lysine	3-9	CD4 molecule	Homo sapiens	145-148
1762917-1	1991	Zinc binding domains and the conserved Thr-Gly-Glu-Lys (TGEK) tetrapeptide in the N-terminal half of transcription factor IIIA (TFIIIA) were subjected to in vitro mutagenesis to biochemically assess their role in factor interaction with the 5S gene internal control region (ICR).	Lysine	51-54	general transcription factor IIIA	Homo sapiens	101-126
1762917-1	1991	Zinc binding domains and the conserved Thr-Gly-Glu-Lys (TGEK) tetrapeptide in the N-terminal half of transcription factor IIIA (TFIIIA) were subjected to in vitro mutagenesis to biochemically assess their role in factor interaction with the 5S gene internal control region (ICR).	Lysine	51-54	general transcription factor IIIA	Homo sapiens	128-134
1748675-9	1991	These results indicate that lysine 262 in aldose reductase and aldehyde reductase is crucial to their catalytic activity by affecting co-factor binding.	Lysine	28-34	aldo-keto reductase family 1 member B	Homo sapiens	42-58
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Lysine	63-66	interleukin 1 beta	Homo sapiens	106-115
1816326-3	1991	This latter effect appears related to increased exposure of arginine- and lysine-rich segments of apoB-100.	Lysine	74-80	apolipoprotein B	Homo sapiens	98-106
1783373-4	1991	The ATP-binding site in the catalytic half of the HK1 protein resembles nucleotide-binding regions from protein kinases, with the single amino acid replacement (lysine to glutamate) in the ATP-binding site of the amino half explaining the loss of HK1 catalytic function in the regulatory domain.	Lysine	161-167	hexokinase 1	Homo sapiens	50-53
1783373-4	1991	The ATP-binding site in the catalytic half of the HK1 protein resembles nucleotide-binding regions from protein kinases, with the single amino acid replacement (lysine to glutamate) in the ATP-binding site of the amino half explaining the loss of HK1 catalytic function in the regulatory domain.	Lysine	161-167	hexokinase 1	Homo sapiens	247-250
1812403-0	1991	The hormone-binding site of neurophysins: binding of vasopressin to the N-terminal sub-domain dissected from human MSEL-neurophysin through endopeptidase Lys-C. Human MSEL-neurophysin has been dissected into two halves by endopeptidase Lys-C, taking advantage of a peculiar Lys59-Ala60 bond.	Lysine	154-157	arginine vasopressin	Homo sapiens	53-64
1667880-3	1991	In the recently discovered family of self-cleaving proteins exemplified by the LexA repressor of Escherichia coli, instead of the imidazole of a histidine, the active-site general-base catalyst was found to be the epsilon-amino of a lysine.	Lysine	233-239	DNA repair system	Escherichia coli	79-83
1751517-12	1991	In parallel with its actions on ASC/asc harmaline competitively inhibited lysine uptake by human cells in sucrose medium.	Lysine	74-80	PYD and CARD domain containing	Homo sapiens	32-35
1751517-12	1991	In parallel with its actions on ASC/asc harmaline competitively inhibited lysine uptake by human cells in sucrose medium.	Lysine	74-80	PYD and CARD domain containing	Homo sapiens	36-39
1939225-3	1991	After single mutation of each of the 5 His residues at positions 363, 368, 373, 391, and 400 by Ser, Cys, or Lys, measurable levels of 5-lipoxygenase activity could be recovered in Escherichia coli only for the Ser363 and Cys363 mutants, with most amino acid substitutions causing a decrease in the levels of expression of the soluble protein.	Lysine	109-112	arachidonate 5-lipoxygenase	Homo sapiens	135-149
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	74-77	interleukin 1 beta	Homo sapiens	10-18
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	78-81	interleukin 1 beta	Homo sapiens	10-18
1835838-3	1991	The human IL1 beta molecule contains a seven-amino-acid sequence (-Pro208-Lys-Lys-Lys-Met-Glu-Lys-) that shows some sequence identity with the nuclear localization sequence of the simian-virus-40 large T-antigen.	Lysine	78-81	interleukin 1 beta	Homo sapiens	10-18
1939204-11	1991	A comparison of the overlapping sequence between these two peptides suggests that this calmodulin binding site is localized in a 7-residue segment, 659Trp-Glu-Lys-Gly-Asn-Val-Phe665.	Lysine	159-162	calmodulin 1	Homo sapiens	87-97
1667689-6	1991	The major form of Anolis alpha-MSH is nonacetylated and has the following novel primary sequence: Ser-Tyr-Ala-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro(Val-amide).	Lysine	138-141	alpha-msh	Anolis carolinensis	25-34
1657983-12	1991	These results suggest that t-PA-R can bind both t-PA and Lys-PLG in a manner that mimics the EC surface.	Lysine	57-60	plasminogen activator, tissue type	Homo sapiens	27-31
1939180-2	1991	Similar Ca2(+)-dependent proteases are also present in pancreatic secretory granules and cleave proinsulin at two sites, Arg-Arg and Lys-Arg.	Lysine	133-136	insulin	Homo sapiens	96-106
1939157-3	1991	The 84-residue form of bovine MGP predicted from the message structure could not be detected in the bone extracellular matrix extracts, and it therefore seems probable that the lysine at position 84 was removed by the action of a carboxypeptidase B-like enzyme prior to secretion.	Lysine	177-183	matrix Gla protein	Bos taurus	30-33
1834252-0	1991	The binding domain of von Willebrand factor to sulfatides is distinct from those interacting with glycoprotein Ib, heparin, and collagen and resides between amino acid residues Leu 512 and Lys 673.	Lysine	189-192	von Willebrand factor	Homo sapiens	22-43
1930145-5	1991	Addition of heparin decreased the glycation in vitro, and EC-SOD C modified with the lysine-specific reagent trinitrobenzenesulphonic acid could not be glycated in vitro.	Lysine	85-91	superoxide dismutase 3	Homo sapiens	58-64
1657140-7	1991	The amino acid sequence accounting for 42% of rabbit paraoxonase was determined by (1) gas-phase sequencing of the intact protein and (2) peptide fragments from lysine and arginine digests.	Lysine	161-167	paraoxonase 1	Homo sapiens	53-64
1918053-7	1991	These midchain reversals include the lysine and asparagine residues proposed to be involved in heparin binding and N-glycosylation, respectively, to laminin peptide F-9.	Lysine	37-43	coagulation factor IX	Homo sapiens	165-168
1656023-9	1991	The pA2 value of Lys-Lys-[Hyp3-Thi5,8D-Phe7]-BK was 6.92 +/- 0.17.	Lysine	17-20	kininogen 1	Homo sapiens	45-47
1656023-9	1991	The pA2 value of Lys-Lys-[Hyp3-Thi5,8D-Phe7]-BK was 6.92 +/- 0.17.	Lysine	21-24	kininogen 1	Homo sapiens	45-47
1909577-0	1991	Biological activity of a fluorescein human growth hormone derivative prepared by specific covalent labeling of lysine-70.	Lysine	111-117	growth hormone 1	Homo sapiens	43-57
1664037-5	1991	It is suggested that modifications to the B29 lysine residue might play a crucial role in stabilising the interaction of conjugated insulin with its cognate receptor.	Lysine	46-52	insulin	Homo sapiens	132-139
1844820-0	1991	Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.	Lysine	73-76	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-38
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Lysine	71-74	fibrinogen beta chain	Homo sapiens	112-122
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Lysine	71-74	fibrinogen beta chain	Homo sapiens	155-165
1680852-17	1991	These results demonstrate that Lys-91 is important for receptor modulation in the stimulation of cAMP synthesis.	Lysine	31-34	cathelicidin antimicrobial peptide	Homo sapiens	97-101
1832675-5	1991	Actin binds to tissue plasminogen activator (t-Pa) (Kd = 0.55 microM), at least partially via lysine-binding sites.	Lysine	94-100	plasminogen activator, tissue type	Homo sapiens	15-49
1909577-8	1991	The present study indicates that out of the seven amino groups of human growth hormone, the epsilon-amino group of lysine-70 is excessively reactive toward FITC.	Lysine	115-121	growth hormone 1	Homo sapiens	72-86
1909331-5	1991	In purified systems, both t-PA and plasminogen bound to immobilized amphoterin, and their binding was inhibited by the lysine analogue epsilon-aminocaproic acid.	Lysine	119-125	plasminogen activator, tissue type	Homo sapiens	26-30
1885583-20	1991	In previous studies, amino acid analysis, which also included acid treatment, indicated that MLG-modified cobra phospholipase A2 contained 2.8 mol of Lys less than the native enzyme.	Lysine	150-153	phospholipase A2 group IB	Homo sapiens	112-128
1909331-9	1991	The results indicate that t-PA and plasminogen form through their lysine-binding sites a complex with amphoterin, which results in acceleration of plasminogen activation and effective degradation of amphoterin.	Lysine	66-72	plasminogen activator, tissue type	Homo sapiens	26-30
1958318-10	1991	The loss of an alpha 1/beta 2-contact by the exchanges alpha 92(FG4)Arg----Leu and beta 43(CD2)Glu----Lys might be responsible for the easy dissociation of the tetrameric hemoglobin molecule.	Lysine	102-105	T-cell surface antigen CD2	Latimeria chalumnae	91-94
1883381-6	1991	ARAP contains 10 cysteines and 30 basic amino acids (23 lysines and 7 arginines).	Lysine	56-63	midkine	Homo sapiens	0-4
1714722-2	1991	Results obtained from both peptide mapping and fast atom bombardment mass spectrometry indicate that tyrosine 67 in the sequence -Thr-Thr-His-Tyr67-Gly-Ser-Leu-Pro-Gln-Lys- in bovine MBP is the specific phosphorylation site.	Lysine	168-171	myelin basic protein	Bos taurus	183-186
1908186-3	1991	Lysine concentration dependence data were fit by a two-system model with Km values of 1.0 +/- 0.8 and 223 +/- 57 microM and Vmax values of 0.06 +/- 0.03 and 24.0 +/- 5.8 pmol.mg protein-1.min-1.	Lysine	0-6	CD59 molecule (CD59 blood group)	Homo sapiens	188-193
1662203-10	1991	Cytochrome c-553 reacted with cytochrome c oxidase of the bacterium and the reaction was greatly accelerated in the presence of poly-L-lysine.	Lysine	128-141	cytochrome c, somatic	Homo sapiens	0-12
1662203-10	1991	Cytochrome c-553 reacted with cytochrome c oxidase of the bacterium and the reaction was greatly accelerated in the presence of poly-L-lysine.	Lysine	128-141	cytochrome c, somatic	Homo sapiens	30-42
2065053-2	1991	This binding has been shown to shield five spatially distant lysines of the thrombin B-chain (Lys21, Lys65, Lys77, Lys106, and Lys107).	Lysine	61-68	coagulation factor II, thrombin	Homo sapiens	76-84
1677358-6	1991	In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT).	Lysine	134-140	apolipoprotein A4	Homo sapiens	41-48
1648965-7	1991	From an inspection of the ferric transferrin crystal structure, the most likely anion binding residues in the cleft are Arg-632 and Lys-534 in the C-terminal lobe and Lys-206 and Lys-296 in the N-terminal lobe.	Lysine	132-135	transferrin	Homo sapiens	33-44
1648965-7	1991	From an inspection of the ferric transferrin crystal structure, the most likely anion binding residues in the cleft are Arg-632 and Lys-534 in the C-terminal lobe and Lys-206 and Lys-296 in the N-terminal lobe.	Lysine	167-170	transferrin	Homo sapiens	33-44
1648965-7	1991	From an inspection of the ferric transferrin crystal structure, the most likely anion binding residues in the cleft are Arg-632 and Lys-534 in the C-terminal lobe and Lys-206 and Lys-296 in the N-terminal lobe.	Lysine	167-170	transferrin	Homo sapiens	33-44
2071607-6	1991	DIDS covalently and selectively modified lysine 90 of soluble CD4 and abolished the gp120-binding and antiviral properties of the recombinant protein.	Lysine	41-47	CD4 molecule	Homo sapiens	62-65
1712984-5	1991	These data indicate that CFTR is a cAMP-regulated chloride channel and that lysines 95 and 335 determine anion selectivity.	Lysine	76-83	CF transmembrane conductance regulator	Homo sapiens	25-29
2065053-4	1991	The major object of this study is to investigate how the decreased activity of the modified hirudin C-terminal peptide is reflected by the change of its binding properties to these five lysines of thrombin.	Lysine	186-193	coagulation factor II, thrombin	Homo sapiens	197-205
2065053-7	1991	Our results demonstrated the following: (1) the anticoagulant activities of hirudin C-terminal peptides were quantitatively related to their abilities to shield the five identified lysines of thrombin.	Lysine	181-188	coagulation factor II, thrombin	Homo sapiens	192-200
2065053-10	1991	(2) All active hirudin C-terminal peptides regardless of their sizes and potencies were shown to be capable of shielding the five lysines of thrombin.	Lysine	130-137	coagulation factor II, thrombin	Homo sapiens	141-149
1793433-4	1991	Proteolytic modification of cytochrome P-450scc and structural analysis indicate that a lysine residue of the C-terminal sequence of cytochrome P-450scc is accessible to FITC.	Lysine	88-94	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	28-47
1793433-4	1991	Proteolytic modification of cytochrome P-450scc and structural analysis indicate that a lysine residue of the C-terminal sequence of cytochrome P-450scc is accessible to FITC.	Lysine	88-94	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	133-152
1889345-2	1991	The serum and urinary levels of glycated albumin were measured by enzyme-immunoassay with monoclonal antibody to glucitol-lysine residues in human glycated albumin.	Lysine	122-128	albumin	Homo sapiens	41-48
1889345-2	1991	The serum and urinary levels of glycated albumin were measured by enzyme-immunoassay with monoclonal antibody to glucitol-lysine residues in human glycated albumin.	Lysine	122-128	albumin	Homo sapiens	156-163
1711072-10	1991	B27-HS now reveals that Lys at position 70 is specific for B27 but Asn at position 97 is not.	Lysine	24-27	melanocortin 2 receptor accessory protein	Homo sapiens	0-3
2055204-3	1991	We have studied the processing of a C-peptide-deleted precursor of neuropeptide Y (NPY) in which the precursor terminates in the sequence Gly-Lys-Arg and does not require any dibasic specific endoproteolytic processing.	Lysine	142-145	pro-neuropeptide Y	Cricetulus griseus	67-81
2055204-3	1991	We have studied the processing of a C-peptide-deleted precursor of neuropeptide Y (NPY) in which the precursor terminates in the sequence Gly-Lys-Arg and does not require any dibasic specific endoproteolytic processing.	Lysine	142-145	pro-neuropeptide Y	Cricetulus griseus	83-86
1711072-10	1991	B27-HS now reveals that Lys at position 70 is specific for B27 but Asn at position 97 is not.	Lysine	24-27	melanocortin 2 receptor accessory protein	Homo sapiens	59-62
2051232-3	1991	Alanine, hydroxyproline and lysine also increased plasma GIP, but insulin concentrations were unchanged.	Lysine	28-34	gastric inhibitory polypeptide	Mus musculus	57-60
1905958-7	1991	Sequencing by Edman degradation over 24 cycles confirmed the identity of the peptide, and by analysis of a portion of the PTH-derivatives showed fluorescence at cycle 11, a lysine residue.	Lysine	173-179	parathyroid hormone	Homo sapiens	122-125
1726506-4	1991	Lysine, as a modifier of electrostatic charge at cell surface, instead of neuraminidase was used to clarify whether the enzyme yields a specific or non-specific influence on CEA expression.	Lysine	0-6	CEA cell adhesion molecule 3	Homo sapiens	174-177
2026586-5	1991	The N-terminal amino acid sequence, Arg-Ala-Pro-Lys-Glu-Val-Pro-Leu-, is different from the N-terminal sequence of any other cytochrome P-450s so far reported.	Lysine	48-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Lysine	320-323	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	288-291
1720827-5	1991	In this study, it is shown that a synthetic peptide, Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu, which corresponds to amino acid residues 4-14 of bovine myelin basic protein, is the most specific and convenient substrate for selective assay of protein kinase C among various phosphate acceptor proteins and peptides.	Lysine	57-60	myelin basic protein	Bos taurus	154-174
1720827-5	1991	In this study, it is shown that a synthetic peptide, Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu, which corresponds to amino acid residues 4-14 of bovine myelin basic protein, is the most specific and convenient substrate for selective assay of protein kinase C among various phosphate acceptor proteins and peptides.	Lysine	85-88	myelin basic protein	Bos taurus	154-174
1832010-4	1991	Regenerating adult axons elongate on a poly-L-lysine/laminin substratum with a speed about one order of magnitude slower than that of embryonic axons.	Lysine	39-52	laminin, beta 2 (laminin S)	Gallus gallus	53-60
1674745-7	1991	A second G to A substitution at amino acid 13 led to the exchange of lysine (AAG) for glutamic acid (GAG), thereby adding 2 positive charge units to the protein and producing the apoE-5 variant.	Lysine	69-75	apolipoprotein E	Homo sapiens	179-183
2026596-2	1991	Insulin stimulated pyruvate dehydrogenase activity in cells that expressed normal insulin receptors (RAT 1 HIRc, and CHO-WT and CHO-T cells), or receptors in which lysine 1018 in the ATP-binding site of the tyrosine kinase domain was exchanged for alanine (RAT 1 A/K1018 and CHO-mut cells).	Lysine	164-170	insulin	Homo sapiens	0-7
1656982-14	1991	Triply substituted modified cytochrome c by pyridoxal phosphate at lysine residues (Lys-79, 86 and one to be identified) abolishes both complex formations and electron transfer activity with succinate cytochrome c reductase or cytochrome oxidase.	Lysine	67-73	cytochrome c, somatic	Homo sapiens	28-40
1656982-14	1991	Triply substituted modified cytochrome c by pyridoxal phosphate at lysine residues (Lys-79, 86 and one to be identified) abolishes both complex formations and electron transfer activity with succinate cytochrome c reductase or cytochrome oxidase.	Lysine	67-73	cytochrome c, somatic	Homo sapiens	201-213
1656982-14	1991	Triply substituted modified cytochrome c by pyridoxal phosphate at lysine residues (Lys-79, 86 and one to be identified) abolishes both complex formations and electron transfer activity with succinate cytochrome c reductase or cytochrome oxidase.	Lysine	84-87	cytochrome c, somatic	Homo sapiens	28-40
1656982-14	1991	Triply substituted modified cytochrome c by pyridoxal phosphate at lysine residues (Lys-79, 86 and one to be identified) abolishes both complex formations and electron transfer activity with succinate cytochrome c reductase or cytochrome oxidase.	Lysine	84-87	cytochrome c, somatic	Homo sapiens	201-213
2012808-7	1991	The insertion at amino acid 379 occurs immediately after a triplet of lysine residues, suggesting that this region might be involved in an essential step in the mechanism of CE and TG transfer, such as the binding of CETP to phosphatidylcholine molecules in the lipoprotein surface.	Lysine	70-76	cholesteryl ester transfer protein	Homo sapiens	217-221
1709427-2	1991	The lysine in position 3 of SP was substituted by arginine and an amino terminal extension (NTE-SP) was added consisting of Lys-Tyr-Gly-Gly-Gly-Gly-Gly-Gly.	Lysine	4-10	tachykinin precursor 1	Homo sapiens	28-30
1903067-5	1991	When the same assay was conducted with fragment X or fragment D of fibrinogen, the kinetic constants increased 3.2 and 2.9-times, respectively, whereas no enhancement was obtained by fragment E. Neither lysine analogues nor monoclonal antibody toward domains of finger and epidermal growth factor of tPA quench the enhancement by fibrinogen.	Lysine	203-209	fibrinogen beta chain	Homo sapiens	67-77
2018799-7	1991	Competitive binding experiments with agarose-bound heparin and soluble GAG also suggest that after formation of insoluble complexes with arterial CSPG and resolubilization the exposure of Lys, Arg-rich segments of apoB-100 is increased.	Lysine	188-191	apolipoprotein B	Homo sapiens	214-222
1901803-1	1991	Chemical modification studies suggest that two residues of bovine pancreatic ribonuclease A (RNase A), Lys-41 and Asp-121, are important for catalysis.	Lysine	103-106	ribonuclease pancreatic	Bos taurus	77-91
1902818-9	1991	All the experiments are consistent with the contention that the G985 mutation, resulting in a lysine to glutamate shift at position 329 in the MCAD polypeptide chain, is the genetic cause of MCAD deficiency in this family.	Lysine	94-100	acyl-CoA dehydrogenase medium chain	Homo sapiens	143-147
1901803-1	1991	Chemical modification studies suggest that two residues of bovine pancreatic ribonuclease A (RNase A), Lys-41 and Asp-121, are important for catalysis.	Lysine	103-106	ribonuclease pancreatic	Bos taurus	93-100
1905550-0	1991	Effects of monoclonal antibodies on tissue-type plasminogen activator (t-PA) binding to lysine, fibrin and heparin and on fibrin-mediated enhancement of one-chain t-PA amidolytic activity.	Lysine	88-94	plasminogen activator, tissue type	Homo sapiens	36-69
1905550-0	1991	Effects of monoclonal antibodies on tissue-type plasminogen activator (t-PA) binding to lysine, fibrin and heparin and on fibrin-mediated enhancement of one-chain t-PA amidolytic activity.	Lysine	88-94	plasminogen activator, tissue type	Homo sapiens	71-75
1905550-1	1991	The effects of 4 monoclonal antibodies against human tissue-type plasminogen activator (t-PA) on binding of t-PA to lysine, fibrin, and heparin, and on fibrin-mediated activation of one-chain t-PA-amidolytic activity were investigated.	Lysine	116-122	plasminogen activator, tissue type	Homo sapiens	53-86
1905550-1	1991	The effects of 4 monoclonal antibodies against human tissue-type plasminogen activator (t-PA) on binding of t-PA to lysine, fibrin, and heparin, and on fibrin-mediated activation of one-chain t-PA-amidolytic activity were investigated.	Lysine	116-122	plasminogen activator, tissue type	Homo sapiens	88-92
1905550-1	1991	The effects of 4 monoclonal antibodies against human tissue-type plasminogen activator (t-PA) on binding of t-PA to lysine, fibrin, and heparin, and on fibrin-mediated activation of one-chain t-PA-amidolytic activity were investigated.	Lysine	116-122	plasminogen activator, tissue type	Homo sapiens	108-112
1905550-1	1991	The effects of 4 monoclonal antibodies against human tissue-type plasminogen activator (t-PA) on binding of t-PA to lysine, fibrin, and heparin, and on fibrin-mediated activation of one-chain t-PA-amidolytic activity were investigated.	Lysine	116-122	plasminogen activator, tissue type	Homo sapiens	108-112
1905550-3	1991	All 4 monoclonal antibodies inhibited binding of intact t-PA to lysine-Sepharose and fibrin, and they suppressed fibrin-mediated activation of one-chain t-PA-amidolytic activity.	Lysine	64-70	plasminogen activator, tissue type	Homo sapiens	56-60
1905550-4	1991	Binding analysis demonstrated that mAB 25 inhibited t-PA binding to lysine-Sepharose and to fibrin as well as fibrin-mediated enhancement of one-chain t-PA-amidolytic activity in a competitive manner with inhibitor constants of 5 nmol/l, 3 nmol/l and 10 nmol/l, respectively.	Lysine	68-74	plasminogen activator, tissue type	Homo sapiens	52-56
1905550-5	1991	It was also shown that free lysine counteracts the association of t-PA with the antibodies.	Lysine	28-34	plasminogen activator, tissue type	Homo sapiens	66-70
1905550-7	1991	Since t-PA possesses two homologous kringle domains which contain fibrin (lysine) binding sites, the results underline the importance of a lysine binding site for fibrin binding by intact t-PA and show that the binding of the enzyme to fibrin and lysine is mediated by the same binding site of a kringle domain.	Lysine	74-80	plasminogen activator, tissue type	Homo sapiens	6-10
1905550-7	1991	Since t-PA possesses two homologous kringle domains which contain fibrin (lysine) binding sites, the results underline the importance of a lysine binding site for fibrin binding by intact t-PA and show that the binding of the enzyme to fibrin and lysine is mediated by the same binding site of a kringle domain.	Lysine	139-145	plasminogen activator, tissue type	Homo sapiens	6-10
1905550-7	1991	Since t-PA possesses two homologous kringle domains which contain fibrin (lysine) binding sites, the results underline the importance of a lysine binding site for fibrin binding by intact t-PA and show that the binding of the enzyme to fibrin and lysine is mediated by the same binding site of a kringle domain.	Lysine	139-145	plasminogen activator, tissue type	Homo sapiens	6-10
1647952-6	1991	It was also found that unlike normal tissue a fraction of the C-terminal VIP precursor peptide, preproVIP 156-170, was having its C-terminal lysine residue removed during processing.	Lysine	141-147	vasoactive intestinal peptide	Homo sapiens	73-76
1999411-3	1991	We now show that of five pancreatic PLA-2 ("Group I" enzymes) tested from different species of mammals, the human enzyme that is most basic both globally (pI 8.7) and locally (Arg-6, Lys-7, and Lys-10) is active toward BPI-treated E. coli (approximately 1-2% activity of the most active Group II PLA-2) whereas the other four PLA-2 are essentially inactive (less than 0.1%).	Lysine	183-186	phospholipase A2 group IB	Homo sapiens	36-41
2006161-3	1991	Endoproteinase Lys-C or a baby hamster kidney cell protease cleaves angiogenin at the peptide bond either between Lys-60 and Asn-61 or between Glu-67 and Asn-68, respectively.	Lysine	15-18	ribonuclease A family member k6	Gallus gallus	68-78
1999411-3	1991	We now show that of five pancreatic PLA-2 ("Group I" enzymes) tested from different species of mammals, the human enzyme that is most basic both globally (pI 8.7) and locally (Arg-6, Lys-7, and Lys-10) is active toward BPI-treated E. coli (approximately 1-2% activity of the most active Group II PLA-2) whereas the other four PLA-2 are essentially inactive (less than 0.1%).	Lysine	194-197	phospholipase A2 group IB	Homo sapiens	36-41
1999411-4	1991	The cDNA of the pig pancreatic PLA-2 (pI 6.4; Arg-6, Ser-7, Lys-10) has been modified by site-specific mutagenesis and the wild-type and mutant PLA-2 have been expressed in and purified from either E. coli or Saccharomyces cerevisiae to determine more precisely the structural determinants of PLA-2 activity toward BPI-treated E. coli.	Lysine	60-63	phospholipase A2, major isoenzyme	Sus scrofa	31-36
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Lysine	27-33	phospholipase A2, major isoenzyme	Sus scrofa	89-94
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Lysine	27-33	phospholipase A2 group IB	Homo sapiens	188-193
1847886-3	1991	HDL3 was glycosylated in vitro to achieve up to 40-50% reductions in free-lysine residues.	Lysine	74-80	HDL3	Homo sapiens	0-4
1847464-10	1991	In this way we identified a functional nuclear localization signal, Leu-Lys-Arg-Pro-Arg-Ser-Pro-Ser-Ser, encompassing amino acids 379 to 386 of the EBNA-1 protein.	Lysine	72-75	EBNA-1	Human gammaherpesvirus 4	148-154
1711526-4	1991	In this report, we summarize evidence that indicates that the heparin-binding and mitogenic activities of HBGF-1 can be dissociated from the receptor-binding activities of the growth factor by site-directed mutagenesis of a single lysine residue.	Lysine	231-237	fibroblast growth factor 1	Homo sapiens	106-112
1899618-2	1991	We have investigated the role of two basic residues near the active site of human carbonic anhydrase III (HCA III), lysine 64 and arginine 67, to determine whether they can account for some of the unique properties of this isozyme.	Lysine	116-122	carbonic anhydrase 3	Homo sapiens	82-104
1848169-13	1991	In order to explain the low fractional clearance of PGC compared with that of PGA and the less marked effect of arginine or lysine infusion on the fractional clearance of PGC, an additional PGC-specific binding site has to be postulated.	Lysine	124-130	progastricsin	Homo sapiens	171-174
1848169-13	1991	In order to explain the low fractional clearance of PGC compared with that of PGA and the less marked effect of arginine or lysine infusion on the fractional clearance of PGC, an additional PGC-specific binding site has to be postulated.	Lysine	124-130	progastricsin	Homo sapiens	171-174
1881392-3	1991	When the alcohol concentration in aqueous solution was elevated, the number of epsilon-amino groups of lysine residues in human serum albumin exposed to the solvent rose from 6-7 in aqueous solution to maximum 20 groups in the aqueous-alcohol solution, respectively.	Lysine	103-109	albumin	Homo sapiens	134-141
1648717-2	1991	The lysine13 of a GRP-27 was substituted by arginine and lysine was added to the amino terminus.	Lysine	4-10	gastrin releasing peptide	Mus musculus	18-21
2000396-2	1991	Seven other truncation mutants of CD4 were expressed well on the cell surface, thus suggesting that the C-terminal amino acids of CD4.Q421stop (-Ser-Glu-Lys-Lys-Thr-Cys) may have the sequence information for ER retention.	Lysine	153-156	CD4 molecule	Homo sapiens	34-37
2000396-2	1991	Seven other truncation mutants of CD4 were expressed well on the cell surface, thus suggesting that the C-terminal amino acids of CD4.Q421stop (-Ser-Glu-Lys-Lys-Thr-Cys) may have the sequence information for ER retention.	Lysine	153-156	CD4 molecule	Homo sapiens	130-142
2000396-2	1991	Seven other truncation mutants of CD4 were expressed well on the cell surface, thus suggesting that the C-terminal amino acids of CD4.Q421stop (-Ser-Glu-Lys-Lys-Thr-Cys) may have the sequence information for ER retention.	Lysine	157-160	CD4 molecule	Homo sapiens	34-37
2000396-2	1991	Seven other truncation mutants of CD4 were expressed well on the cell surface, thus suggesting that the C-terminal amino acids of CD4.Q421stop (-Ser-Glu-Lys-Lys-Thr-Cys) may have the sequence information for ER retention.	Lysine	157-160	CD4 molecule	Homo sapiens	130-142
2000396-6	1991	Thus lysine at the third position and a positively charged amino acid either at the fourth or fifth position from the C terminus are sufficient for ER retention of this CD4 mutant, and possibly all transmembrane proteins.	Lysine	5-11	CD4 molecule	Homo sapiens	169-172
1990431-2	1991	The retinal chromophore in rhodopsin is bound by means of a protonated Schiff base linkage to the epsilon-amino group of Lys-296.	Lysine	121-124	rhodopsin	Homo sapiens	27-36
1899564-3	1991	The arginine/lysine preference was determined with three pairs of tripeptidyl-p-nitroanilide substrates having either arginine or lysine in the P1 position and varied from 5.2 to 14.1 for u-PA and from 55.6 to 99.8 for t-PA.	Lysine	13-19	plasminogen activator, urokinase	Homo sapiens	188-192
1899564-3	1991	The arginine/lysine preference was determined with three pairs of tripeptidyl-p-nitroanilide substrates having either arginine or lysine in the P1 position and varied from 5.2 to 14.1 for u-PA and from 55.6 to 99.8 for t-PA.	Lysine	13-19	plasminogen activator, tissue type	Homo sapiens	219-223
1899564-5	1991	However, u-PA had a significantly lower arginine/lysine preference than t-PA, indicating that u-PA represents a less specific proteinase.	Lysine	49-55	plasminogen activator, urokinase	Homo sapiens	9-13
1824817-2	1991	These charge alterations were accomplished either by insertion of new Lys residues or by substitution of Lys residues for Glu in two of the seven calmodulin alpha-helices.	Lysine	105-108	calmodulin 1	Homo sapiens	146-156
1780610-1	1991	Results of PrP gene analysis in 5 of 9 members from a Jewish Tunisian family with Creutzfeldt-Jakob disease (CJD) showed a mutation at codon 200 involving substitution of lysine (Lys200) for glutamic acid (Glu200).	Lysine	171-177	prion protein	Homo sapiens	11-14
1817672-0	1991	A new radioimmunoassay for the determination of the angiotensin-converting enzyme inhibitor perindopril and its active metabolite in plasma and urine: advantages of a lysine derivative as immunogen to improve the assay specificity.	Lysine	167-173	angiotensin I converting enzyme	Homo sapiens	52-81
1894196-7	1991	The interaction of hirudin (specifically the region of Lys-47) with the basic specificity pocket of thrombin may contribute to the binding but is not essential for its inhibitory activity.	Lysine	55-58	coagulation factor II, thrombin	Homo sapiens	100-108
2045542-3	1991	Both sVT and sIT precursors were found to contain a signal peptide and hormone that is connected to a neurophysin by a Gly-Lys-Arg sequence.	Lysine	123-126	signaling threshold regulating transmembrane adaptor 1	Homo sapiens	13-16
1647004-1	1991	Lysine occupies position 13 in the parathyroid hormone (PTH) antagonist, [Nle8,18,Tyr34]bPTH(7-34)NH2.	Lysine	0-6	parathyroid hormone	Homo sapiens	35-54
1647004-1	1991	Lysine occupies position 13 in the parathyroid hormone (PTH) antagonist, [Nle8,18,Tyr34]bPTH(7-34)NH2.	Lysine	0-6	parathyroid hormone	Homo sapiens	56-59
1647004-2	1991	Acylation of the epsilon-amino group in lysine 13 by a hydrophobic moiety is well tolerated in terms of bioactivity: the analog [Nle8,18, D-Trp12,Lys 13 (epsilon-3-phenylpropanoyl),Tyr34]bPTH(7-34)NH2 is equivalent to the parent peptide in its affinity for PTH receptors and its ability to inhibit PTH-stimulated adenylate cyclase in both kidney- and bone-based assays.	Lysine	40-46	parathyroid hormone	Homo sapiens	188-191
1647004-2	1991	Acylation of the epsilon-amino group in lysine 13 by a hydrophobic moiety is well tolerated in terms of bioactivity: the analog [Nle8,18, D-Trp12,Lys 13 (epsilon-3-phenylpropanoyl),Tyr34]bPTH(7-34)NH2 is equivalent to the parent peptide in its affinity for PTH receptors and its ability to inhibit PTH-stimulated adenylate cyclase in both kidney- and bone-based assays.	Lysine	40-46	parathyroid hormone	Homo sapiens	257-260
2257621-3	1990	Accordingly, we expressed in L cells mutant uvomorulin with a replacement of Asp to Lys or Ala.	Lysine	84-87	cadherin 1	Homo sapiens	44-54
2260977-7	1990	The alpha-MSH sequence is C-terminally flanked by the Gly-Lys-Lys amidation signal while the joining peptide is not amidate.	Lysine	58-61	proopiomelanocortin	Homo sapiens	10-13
2260977-7	1990	The alpha-MSH sequence is C-terminally flanked by the Gly-Lys-Lys amidation signal while the joining peptide is not amidate.	Lysine	62-65	proopiomelanocortin	Homo sapiens	10-13
2250008-4	1990	The enzyme, named prorenin converting enzyme, specifically cleaves the peptide bond on the COOH-side of the Arg residue at the Lys-Arg pair of mouse Ren 2 prorenin, but does not cleave mouse Ren 1 and human prorenins.	Lysine	127-130	renin 1 structural	Mus musculus	149-152
2250008-7	1990	The results also demonstrated that the presence of a Pro residue next to the Lys-Arg pair prevents the processing of Ren 1 prorenin.	Lysine	77-80	renin 1 structural	Mus musculus	117-120
1701753-0	1990	Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2.	Lysine	29-35	dihydrolipoamide S-acetyltransferase	Homo sapiens	77-83
1701753-6	1990	Because lipoic acid is covalently bound to the zeta-amino group of the lysine residue of PDC-E2, the mutants were designed to replace the lysine residue in the lipoyl domain with glutamine, a negatively charged amino acid; histidine, a positively charged amino acid; and tyrosine, an aromatic amino acid.	Lysine	71-77	dihydrolipoamide S-acetyltransferase	Homo sapiens	89-95
1701753-6	1990	Because lipoic acid is covalently bound to the zeta-amino group of the lysine residue of PDC-E2, the mutants were designed to replace the lysine residue in the lipoyl domain with glutamine, a negatively charged amino acid; histidine, a positively charged amino acid; and tyrosine, an aromatic amino acid.	Lysine	138-144	dihydrolipoamide S-acetyltransferase	Homo sapiens	89-95
1963688-0	1990	Involvement of aspartic and glutamic residues in kringle-2 of tissue-type plasminogen activator in lysine binding, fibrin binding and stimulation of activity as revealed by chemical modification and oligonucleotide-directed mutagenesis.	Lysine	99-105	plasminogen activator, tissue type	Homo sapiens	62-95
1963688-1	1990	Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	55-88
1963688-1	1990	Modification of glutamic and aspartic acid residues of tissue-type plasminogen activator (t-PA) with 1-ethyl-3(3-dimethyl-aminopropyl)-carbodiimide leads to a decrease in affinity for lysine and fibrin, to a decrease of plasminogen activation activity in the presence of a fibrin mimic, but leaves amidolytic activity and plasminogen activation without fibrin mimic unaffected.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	90-94
1963688-2	1990	Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in K2 of t-PA are involved in stimulation of activity, lysine binding and fibrin binding.	Lysine	175-181	plasminogen activator, tissue type	Homo sapiens	60-64
1963688-2	1990	Experiments with kringle-2 ligands and a deletion mutant of t-PA (K2P) suggests that glutamic or aspartic acid residues in K2 of t-PA are involved in stimulation of activity, lysine binding and fibrin binding.	Lysine	175-181	plasminogen activator, tissue type	Homo sapiens	129-133
1707854-0	1990	Monoclonal antibodies to monomeric rat liver metallothionein-I: the immunoreactivity of lysine residues in metallothionein.	Lysine	88-94	metallothionein 1	Rattus norvegicus	45-62
2121735-5	1990	In addition, sequence similarities obtained with the NAD(P)+ amino acid dehydrogenases suggest that (i) lysine 893 may interact with the substrates of poly(ADP-ribose)polymerase and (ii) the COOH-terminal part of the 40-kDa fragment may also contain a Rossman fold structure.	Lysine	104-110	poly(ADP-ribose) polymerase 1	Homo sapiens	151-177
2174048-8	1990	Lysine and epsilon-aminocaproic acid could inhibit the binding of plasminogens and plasminogen derivatives with fibrin and block the enhancement effect of fibrinogen degradation products on plasminogen activation.	Lysine	0-6	fibrinogen beta chain	Homo sapiens	155-165
1699952-6	1990	27:671-678) implicated lysine 132 in HBGF-1 (acidic fibroblast growth factor) as being important to the heparin-binding, receptor-binding, and mitogenic activities of the protein.	Lysine	23-29	fibroblast growth factor 1	Homo sapiens	37-43
1699952-8	1990	Replacement of this lysine with glutamic acid reduces the apparent affinity of HBGF-1 for immobilized heparin (elutes at 0.45 M NaCl vs. 1.1 M NaCl for wild-type).	Lysine	20-26	fibroblast growth factor 1	Homo sapiens	79-85
2228236-4	1990	Amino acid sequence analysis of the hybrid protein yielded the sequence Ser-Thr-Gln-Ser-Asn-Lys-Lys, indicating that STb-PhoA was processed during export in a fashion identical to that of native STb (Y. M. Kupersztoch, K. Tachias, C. R. Moomaw, L. A. Dreyfus, R. G. Urban, C. Slaughter, and S. Whipp, J. Bacteriol.	Lysine	96-99	alkaline phosphatase, biomineralization associated	Rattus norvegicus	121-125
2145980-9	1990	The stimulatory effects of fibrin and partially plasmin-degraded fibrin on one-chain t-PA are suppressed by epsilon-aminocaproic acid and by a monoclonal antibody directed against the lysine binding site of t-PA.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	85-89
2145980-9	1990	The stimulatory effects of fibrin and partially plasmin-degraded fibrin on one-chain t-PA are suppressed by epsilon-aminocaproic acid and by a monoclonal antibody directed against the lysine binding site of t-PA.	Lysine	184-190	plasminogen activator, tissue type	Homo sapiens	207-211
2145980-10	1990	The latter findings support the notion that fibrin activation of one-chain t-PA is mediated by the lysine binding site on kringel domains of the enzyme.	Lysine	99-105	plasminogen activator, tissue type	Homo sapiens	75-79
2170375-10	1990	A domain on the GRP molecule involving Lys-13 or Arg-17 was identified which promoted binding to the GRP receptor under conditions of low ionic strength.	Lysine	39-42	gastrin releasing peptide	Mus musculus	16-19
2170375-10	1990	A domain on the GRP molecule involving Lys-13 or Arg-17 was identified which promoted binding to the GRP receptor under conditions of low ionic strength.	Lysine	39-42	gastrin releasing peptide	Mus musculus	101-104
1963299-0	1990	Inhibitory activity and protein binding of L-lysine derivatives as angiotensin converting enzyme inhibitors.	Lysine	43-51	angiotensin I converting enzyme	Homo sapiens	67-96
2172007-8	1990	This demonstrates that only a single lysine residue in calmodulin is conjugated to ubiquitin.	Lysine	37-43	calmodulin 1	Homo sapiens	55-65
2401289-7	1990	Probably, pyridoxal 5"-phosphate forms a Schiff base with a critical lysine group of the ecdysteroid receptor, presumably at its DNA-binding site.	Lysine	69-75	Ecdysone receptor	Drosophila melanogaster	89-109
2123232-0	1990	Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics.	Lysine	46-52	apolipoprotein A1	Homo sapiens	81-109
2123232-4	1990	The absolute production rates of very low density lipoprotein apoB-100 were 11.4 +/- 5.8 (leucine), 11.2 +/- 6.8 (valine), and 11.1 +/- 5.4 (lysine) mg per kg per day (mean +/- SDM).	Lysine	141-147	apolipoprotein B	Homo sapiens	62-70
2123232-5	1990	The absolute production rates for low density lipoprotein apoB-100 were 8.0 +/- 4.7 (leucine), 7.5 +/- 3.8 (valine), and 7.5 +/- 4.2 (lysine) mg per kg per day.	Lysine	134-140	apolipoprotein B	Homo sapiens	58-66
2123232-6	1990	The absolute production rates for high density lipoprotein apoA-I were 9.7 +/- 0.2 (leucine), 9.4 +/- 1.7 (valine, and 9.1 +/- 1.3 (lysine) mg per kg per day.	Lysine	132-138	apolipoprotein A1	Homo sapiens	59-65
1964787-1	1990	The results presented here indicate that there are two slowly exchanging conformational isomers in unfolded bovine pancreatic ribonuclease A (RNase A) in the vicinity of Lys-41.	Lysine	170-173	ribonuclease pancreatic	Bos taurus	126-140
1964787-1	1990	The results presented here indicate that there are two slowly exchanging conformational isomers in unfolded bovine pancreatic ribonuclease A (RNase A) in the vicinity of Lys-41.	Lysine	170-173	ribonuclease pancreatic	Bos taurus	142-149
1964787-4	1990	These results were obtained from a chemically modified form of the protein, CL(7-41) RNase A, that has a dinitrophenyl cross-link between the epsilon-amino groups of Lys-7 and Lys-41.	Lysine	166-169	ribonuclease pancreatic	Bos taurus	85-92
1964787-4	1990	These results were obtained from a chemically modified form of the protein, CL(7-41) RNase A, that has a dinitrophenyl cross-link between the epsilon-amino groups of Lys-7 and Lys-41.	Lysine	176-179	ribonuclease pancreatic	Bos taurus	85-92
2394713-7	1990	It has a neutral pH optimum and cleaves COOH-terminal Arg or Lys in bradykinin and in shorter peptides.	Lysine	61-64	kininogen 1	Canis lupus familiaris	68-78
2279848-3	1990	These two segments are homologous to two corresponding regions in the two purine nucleotide binding proteins, bacterial elongation factor (EF-tu) (Val 12-Thr 28 corresponds to segment 1; His 78-Ile 92 corresponds to segment 2) and adenylate kinase (ADK) (Lys 9-Cys 25 corresponds to segment 1 and Tyr 95-Arg 107 corresponds to segment 2).	Lysine	255-258	Tu translation elongation factor, mitochondrial	Homo sapiens	139-144
1699121-3	1990	In contrast, the N-terminal SP1-4 fragment (Arg-Pro-Lys-Pro) suppressed the response at a dose of 0.1 microgram/ml, but stimulated it slightly at higher doses (1-5 micrograms/ml).	Lysine	52-55	Sp1 transcription factor	Homo sapiens	28-33
2387866-2	1990	C1-r alpha extended from residues 1 to 208 of C1-r A chain, with at least two cleavage sites within disulfide loops, after lysine 134 and arginine 202.	Lysine	123-129	complement C1r	Homo sapiens	0-4
2117549-4	1990	The activities of lysine catabolizing enzymes such as AadAT, lysine alpha-ketoglutarate reductase and saccharopine dehydrogenase in the bovine tissues were significantly lower than those found in rat tissues.	Lysine	18-24	aminoadipate aminotransferase	Bos taurus	54-59
2143185-9	1990	In contrast, partial inhibition by Glu-plasminogen of t-PA K2 domain-mediated fibrin binding is observed that is dependent on carboxyl-terminal lysines, exposed in fibrin upon limited plasmin digestion.	Lysine	144-151	plasminogen activator, tissue type	Homo sapiens	54-58
2143185-12	1990	It is concluded that t-PA and Glu-plasminogen can bind to the same carboxyl-terminal lysines in limitedly digested fibrin, whereas binding sites composed of intrachain lysines are unique both for the K2 domain of t-PA and the Glu-plasminogen kringles.	Lysine	85-92	plasminogen activator, tissue type	Homo sapiens	21-25
2119800-0	1990	Affinity labeling of lysine-149 in the anion-binding exosite of human alpha-thrombin with an N alpha-(dinitrofluorobenzyl)hirudin C-terminal peptide.	Lysine	21-27	coagulation factor II, thrombin	Homo sapiens	76-84
1698454-0	1990	Mutagenesis of residues flanking Lys-40 enhances the enzymatic activity and reduces the angiogenic potency of angiogenin.	Lysine	33-36	ribonuclease A family member k6	Gallus gallus	110-120
1698454-1	1990	The primary structure of the blood vessel inducing protein angiogenin is 35% identical with that of pancreatic ribonuclease (RNase) and contains counterparts for the critical RNase active-site residues His-12, Lys-41, and His-119.	Lysine	210-213	ribonuclease A family member k6	Gallus gallus	59-69
1698454-3	1990	Comparison of the amino acid sequences of RNase and angiogenin reveals several striking differences in the region flanking the active-site lysine, including a deletion and a transposition of aspartic acid and proline residues.	Lysine	139-145	ribonuclease A family member k6	Gallus gallus	52-62
1698454-7	1990	Thus, non-active-site residues near Lys-40 in angiogenin appear to play a significant role in determining enzymatic specificity and reactivity as well as angiogenic potency.	Lysine	36-39	ribonuclease A family member k6	Gallus gallus	46-56
2115513-2	1990	The variant cDNAs were designed to increase the fibrin affinity of t-PA by mutagenesis in the kringle domains of specific amino acids which are assumed to constitute the lysine-binding site.	Lysine	170-176	plasminogen activator, tissue type	Homo sapiens	67-71
2223769-3	1990	Mutations to neutralize the basic charge at Arg 72 (R72Q) and to both neutralize and reverse the charge at Lys 344 (K344Q, K344E) resulted in alteration of NADH oxidation rates in the reconstituted physiological electron-transfer system, which is rate limited by putidaredoxin-cytochrome P-450cam electron transfer.	Lysine	107-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	277-293
2226525-6	1990	With controlled proteolytic hydrolysis, we found that the interaction of LDL with CSPG modifies the surface accessibility of a apoB-100 segments containing arginine and lysine.	Lysine	169-175	apolipoprotein B	Homo sapiens	127-135
2293020-6	1990	Using these methods we have analyzed samples of DNA prepared from a patient with complete androgen resistance and have detected a single nucleotide substitution at nucleotide 1924 in exon 3 of the androgen receptor gene that results in the conversion of a lysine codon into a premature termination codon at amino acid position 588.	Lysine	256-262	androgen receptor	Homo sapiens	197-214
2384157-1	1990	A glutamic acid to lysine change in the Z variant of human alpha 1-antitrypsin is associated with a failure to secrete the protein from synthesising cells.	Lysine	19-25	serpin family A member 1	Homo sapiens	59-78
2119800-7	1990	Automated Edman degradation of the peptide fragments allowed identification of Lys-149 of human thrombin as the major site of DNFB-Hir54-64 derivatization.	Lysine	79-82	coagulation factor II, thrombin	Homo sapiens	96-104
2187871-8	1990	Factor eIF-4D is the only known mammalian protein that undergoes a unique post-translational modification of Lys-50 to the amino acid hypusine, and interestingly the same lysine is also present in the ANB1 gene product.	Lysine	171-177	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	201-205
2113057-6	1990	The k1 value for tcwt-rtPA was not influenced by the presence of epsilon-aminocaproic acid, suggesting that the lysine-binding site associated with the kringle 2 (K2) region of tPA does not modulate the rate of its initial interaction with rPAI-1.	Lysine	112-118	plasminogen activator, tissue type	Homo sapiens	23-26
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Lysine	97-100	insulin	Homo sapiens	3-10
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	198-201	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	206-209	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	206-209	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2159332-2	1990	Cytochrome c derivatives labeled at single lysine amino groups with ruthenium bisbipyridine dicarboxybipyridine were prepared as previously described [Pan, L.P., Durham, B., Wolinska, J., &amp; Millett, F. (1988) Biochemistry 27, 7180-7184].	Lysine	43-49	cytochrome c, somatic	Homo sapiens	0-12
2110481-3	1990	In contrast, two basic amino acid transport systems in a gap1 mutant of Saccharomyces cerevisiae are influenced by NH4+ ions in such a way that only the Jmax decreases while the KT of L-lysine transport is unchanged.	Lysine	184-192	amino acid permease GAP1	Saccharomyces cerevisiae S288C	57-61
2110898-0	1990	Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s.	Lysine	47-50	complement C1s	Homo sapiens	78-81
2112946-0	1990	Quenching of the amidolytic activity of one-chain tissue-type plasminogen activator by mutation of lysine-416.	Lysine	99-105	plasminogen activator, tissue type	Homo sapiens	50-83
2112946-2	1990	The hypothesis that lysine residues 277 or 416 may be involved in stabilization of an active conformation of one-chain t-PA via salt-bridge formation with aspartic acid residue 477 was tested by site-directed mutagenesis.	Lysine	20-26	plasminogen activator, tissue type	Homo sapiens	119-123
2112946-6	1990	The amidolytic activity of [R275G]t-PA was comparable to that of authentic one-chain t-PA, and so was the activity of [R275L,K277L]t-PA, in which additional substitution of lysine residue 277 was carried out.	Lysine	173-179	plasminogen activator, tissue type	Homo sapiens	34-38
2112946-8	1990	In contrast, substitution of lysine residue 416 to obtain [K416S]t-PA and [K416S,H417T]t-PA resulted in substantial quenching of amidolytic one-chain activity.	Lysine	29-35	plasminogen activator, tissue type	Homo sapiens	65-69
2112946-8	1990	In contrast, substitution of lysine residue 416 to obtain [K416S]t-PA and [K416S,H417T]t-PA resulted in substantial quenching of amidolytic one-chain activity.	Lysine	29-35	plasminogen activator, tissue type	Homo sapiens	87-91
2112946-10	1990	Involvement of lysine residue 416 in one-chain t-PA activity was also indicated by decreased activities of [K416S]t-PA and [K416S,H417T]t-PA with plasminogen as the substrate.	Lysine	15-21	plasminogen activator, tissue type	Homo sapiens	47-51
2112946-10	1990	Involvement of lysine residue 416 in one-chain t-PA activity was also indicated by decreased activities of [K416S]t-PA and [K416S,H417T]t-PA with plasminogen as the substrate.	Lysine	15-21	plasminogen activator, tissue type	Homo sapiens	114-118
2112946-10	1990	Involvement of lysine residue 416 in one-chain t-PA activity was also indicated by decreased activities of [K416S]t-PA and [K416S,H417T]t-PA with plasminogen as the substrate.	Lysine	15-21	plasminogen activator, tissue type	Homo sapiens	114-118
2348567-7	1990	G-Fbg measured by this method correlated significantly with the amount of furosine that was a specific product by hydrolysis of glycated lysine residue.	Lysine	137-143	fibrinogen beta chain	Homo sapiens	2-5
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Lysine	107-110	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Lysine	107-110	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Lysine	107-110	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Lysine	107-110	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Lysine	128-131	insulin	Homo sapiens	46-53
2334677-6	1990	CDPK phosphorylated lysine-rich histone III-S and chicken gizzard myosin light chains but did not phosphorylate arginine-rich histone, phosvitin, casein, protamine, or Kemptide.	Lysine	20-26	calcium-dependent protein kinase 1	Glycine max	0-4
2129390-5	1990	In the presence of fibrinogen, activation rates for both Lys and Glu-plasminogen were increased.	Lysine	57-60	fibrinogen beta chain	Homo sapiens	19-29
2317208-3	1990	The results provide strong evidence that codon 501 in albumin Kashmir is AAG (lysine) instead of GAG (glutamic acid), thus confirming the protein sequences reported.	Lysine	78-84	albumin	Homo sapiens	54-61
2111340-3	1990	Infusion with Methionine plus lysine increased milk protein content when cows fed either diet but increased milk fat content and yield only when the soybean meal diet was fed.	Lysine	30-36	casein beta	Bos taurus	47-59
2407296-8	1990	The other pigeon metallothionein has lysine at its carboxyl terminus and is devoid of arginine.	Lysine	37-43	metallothionein 4	Gallus gallus	17-32
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	48-50	ADP-ribosyltransferase 1	Mus musculus	0-5
2083242-7	1990	These studies show that lysine residues of bovine serum albumin are not important in bromophenol blue binding.	Lysine	24-30	albumin	Homo sapiens	50-63
2105083-7	1990	A peptide analogous to the calcium binding regions of calmodulin, Asp-Lys-Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys-Glu, is also converted, upon heating, to chromatographically different forms in reversed-phase chromatography.	Lysine	70-73	calmodulin 1	Homo sapiens	54-64
2302415-7	1990	Owing to the intricate contact between the lipidic core and the apolipoproteins, the Trp residues of human serum LDL and HDL3 are very rapidly oxidized, i.e., at least one order of magnitude faster than Tyr HDL and Lys LDL, which are believed to be involved in the binding of these lipoproteins to their cell receptors.	Lysine	215-218	HDL3	Homo sapiens	121-125
2105240-0	1990	The cosubstrate NADP(H) protects lysine 601 in the porcine NADPH-cytochrome P-450 reductase against pyridoxylation.	Lysine	33-39	cytochrome p450 oxidoreductase	Homo sapiens	59-91
2119550-0	1990	Enhancement of aldose reductase activity by modification of an active site lysine: a possible mechanism for in vivo activation.	Lysine	75-81	aldo-keto reductase family 1 member B	Homo sapiens	15-31
2119550-1	1990	Reaction of aldose reductase (ALR2) from pig muscle with pyridoxal 5"-phosphate (pyridoxal-P) and other lysine modifying reagents resulted in activation of the enzyme.	Lysine	104-110	aldo-keto reductase family 1 member B	Sus scrofa	12-28
2119550-1	1990	Reaction of aldose reductase (ALR2) from pig muscle with pyridoxal 5"-phosphate (pyridoxal-P) and other lysine modifying reagents resulted in activation of the enzyme.	Lysine	104-110	aldo-keto reductase family 1 member B	Sus scrofa	30-34
1971226-3	1990	The incorporation of serine protease inhibitors within the experimental procedures suggested that Thy-1 bound to the lysine-containing, protein-binding domain of t-PA thus leaving the active site available to interact with other proteins.	Lysine	117-123	Thy-1 cell surface antigen	Rattus norvegicus	98-103
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	amyloid beta precursor protein	Homo sapiens	62-68
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	histocompatibility 2, class II antigen A, beta 1	Mus musculus	207-213
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	144-146	ADP-ribosyltransferase 1	Mus musculus	0-5
2300531-10	1990	Incubation of TG with poly-L-lysine also resulted in irreversible binding but to a lesser extent than with HSA.	Lysine	22-35	albumin	Homo sapiens	107-110
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	histocompatibility 2, class II antigen A, beta 1	Mus musculus	207-213
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	histocompatibility 2, class II antigen A, beta 1	Mus musculus	207-213
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	histocompatibility 2, class II antigen A, beta 1	Mus musculus	207-213
2404065-11	1990	Sequence comparison of DR beta, DP beta, DQ beta, E beta, and A beta chains in this region revealed a single residue (position 12) conserved in most chains and differing in a nonconservative fashion between A beta d vs A beta b or k. A beta d has the conserved lysine at this position, whereas A beta b has methionine and A beta k has glutamine.	Lysine	261-267	amyloid beta precursor protein	Homo sapiens	207-213
2404065-12	1990	To test whether this residue actually was important physiologically, a lysine codon was created in a recombinant A beta gene possessing the amino-terminal sequence of the kappa haplotype, and the ability of this mutant chain to be expressed with various mouse A alpha-chains was examined.	Lysine	71-77	histocompatibility 2, class II antigen A, beta 1	Mus musculus	113-119
2100004-1	1990	Conformation of the renin inhibitor peptide, Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys (RIP) has been studied in aqueous solution and in lipid bilayers using 500 MHz 1H NMR spectroscopy.	Lysine	81-84	renin	Homo sapiens	20-25
2106595-4	1990	Lysine- and zinc- chelating affinity chromatography revealed that the peak C consist with the light chain (L-chain) of t-PA.	Lysine	0-6	plasminogen activator, tissue type	Homo sapiens	119-123
21043983-4	1990	Binding of LDL by platelets was rapid and apparently mediated by recognition of positively charged arginine and lysine residues within the protein constituent (apoB) of LDL, findings previously reported as characteristics of LDL stimulation of platelet aggregation.	Lysine	112-118	apolipoprotein B	Homo sapiens	160-164
33971063-1	2021	The lysine methyltransferase SETDB1, an enzyme responsible for methylation of histone H3 at lysine 9, plays a key role in H3K9 tri-methylation dependent silencing of endogenous retroviruses and developmental genes.	Lysine	4-10	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	29-35
33971063-1	2021	The lysine methyltransferase SETDB1, an enzyme responsible for methylation of histone H3 at lysine 9, plays a key role in H3K9 tri-methylation dependent silencing of endogenous retroviruses and developmental genes.	Lysine	92-98	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	29-35
33940558-3	2021	In response to DNA strand breaks, PARP1 covalently attaches ADP-ribose moieties to arginine, glutamate, aspartate, cysteine, lysine, and serine acceptor sites on both itself and other proteins.	Lysine	125-131	poly(ADP-ribose) polymerase 1	Homo sapiens	34-39
32795105-1	2021	The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation.	Lysine	81-87	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	4-8
33793773-7	2021	Mutagenesis of certain conserved lysines near the dimer interface restored the levels of Msh2 in the absence of Msh6, further supporting a dimer stabilization mechanism.	Lysine	33-40	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	89-93
33808501-9	2021	The PLLA/HAP scaffolds modified with l-lysine stimulated hFOB 1.19 osteoblasts proliferation.	Lysine	37-45	BAG cochaperone 1	Homo sapiens	9-12
33821003-4	2021	Here, we show that PRC1-mediated formation of lysine 119-monoubiquititinated histone H2A (H2AK119ub1) confers maternally heritable H3K27me3.	Lysine	46-52	protein regulator of cytokinesis 1	Mus musculus	19-23
33821005-1	2021	Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A at lysine 119 (H2AK119ub1) and trimethylated histone H3 at lysine 27 (H3K27me3), respectively.	Lysine	178-184	protein regulator of cytokinesis 1	Mus musculus	39-45
33821005-1	2021	Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A at lysine 119 (H2AK119ub1) and trimethylated histone H3 at lysine 27 (H3K27me3), respectively.	Lysine	234-240	protein regulator of cytokinesis 1	Mus musculus	39-45
27452519-3	2017	Among different covalent modifications found on p53 the most controversial one is lysine methylation.	Lysine	82-88	tumor protein p53	Homo sapiens	48-51
33802888-6	2021	Co-crystal structures of these five inhibitors with human Brd4 bromodomain demonstrated that it has a key binding mode occupying the hydrophobic pocket, which is known to be the acetylated lysine binding site.	Lysine	189-195	bromodomain containing 4	Homo sapiens	58-62
33589814-2	2021	We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the complex selectively ubiquitylates lysines 125, 127 and 129 in the flexible C-terminal tail of H2A in a fully human system.	Lysine	216-223	ubiquitin conjugating enzyme E2 D3	Homo sapiens	70-79
33589814-2	2021	We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the complex selectively ubiquitylates lysines 125, 127 and 129 in the flexible C-terminal tail of H2A in a fully human system.	Lysine	216-223	ubiquitin conjugating enzyme E2 D3	Homo sapiens	80-86
33234150-6	2020	We reveal that POL2A inhibits DNA methylation and histone H3 lysine 9 methylation.	Lysine	61-67	DNA polymerase epsilon catalytic subunit	Arabidopsis thaliana	15-20
32494966-6	2020	Vasohibin-1 was associated with Ly (P = 0.003) and pT (P = 0.037), whereas vasohibin-2 was associated with Ly (P < 0.001), V (P < 0.001) and pStage (P < 0.001).	Lysine	107-109	vasohibin 2	Homo sapiens	75-86
33800594-1	2021	Activation of trimethylation of histone 3 lysine 27 (H3K27me3) by EZH2, a component of the Polycomb repressive complex 2 (PRC2), is suggested to play a role in endometriosis.	Lysine	42-48	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	66-70
32859246-0	2020	Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer.	Lysine	0-6	lactate dehydrogenase A	Homo sapiens	58-81
32859246-11	2020	We demonstrated that CPT1A functions as a lysine succinyltransferase that interacts with and succinylates LDHA.	Lysine	42-48	carnitine palmitoyltransferase 1A	Homo sapiens	21-26
32859246-11	2020	We demonstrated that CPT1A functions as a lysine succinyltransferase that interacts with and succinylates LDHA.	Lysine	42-48	lactate dehydrogenase A	Homo sapiens	106-110
29137412-6	2017	Additionally, RNA immunoprecipitation (RIP) assays showed that SNHG15 epigenetically repressed the P15 and Kruppel-like factor 2 (KLF2) expression via binding to enhancer of zeste homolog 2 (EZH2), and chromatin immunoprecipitation assays (CHIP) assays demonstrated that EZH2 was capable of binding to promoter regions of P15 and KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	356-362	cyclin dependent kinase inhibitor 2B	Homo sapiens	99-128
29137412-6	2017	Additionally, RNA immunoprecipitation (RIP) assays showed that SNHG15 epigenetically repressed the P15 and Kruppel-like factor 2 (KLF2) expression via binding to enhancer of zeste homolog 2 (EZH2), and chromatin immunoprecipitation assays (CHIP) assays demonstrated that EZH2 was capable of binding to promoter regions of P15 and KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	356-362	Kruppel like factor 2	Homo sapiens	130-134
29137412-6	2017	Additionally, RNA immunoprecipitation (RIP) assays showed that SNHG15 epigenetically repressed the P15 and Kruppel-like factor 2 (KLF2) expression via binding to enhancer of zeste homolog 2 (EZH2), and chromatin immunoprecipitation assays (CHIP) assays demonstrated that EZH2 was capable of binding to promoter regions of P15 and KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	356-362	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	162-189
29137412-6	2017	Additionally, RNA immunoprecipitation (RIP) assays showed that SNHG15 epigenetically repressed the P15 and Kruppel-like factor 2 (KLF2) expression via binding to enhancer of zeste homolog 2 (EZH2), and chromatin immunoprecipitation assays (CHIP) assays demonstrated that EZH2 was capable of binding to promoter regions of P15 and KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	356-362	cyclin dependent kinase inhibitor 2B	Homo sapiens	99-102
23236377-0	2012	Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.	Lysine	28-34	sirtuin 3	Homo sapiens	104-109
26260510-1	2015	The histone acetyltransferase Sas2 is part of the SAS-I complex and acetylates lysine 16 of histone H4 (H4 K16Ac) in the genome of Saccharomyces cerevisiae.	Lysine	79-85	histone acetyltransferase	Saccharomyces cerevisiae S288C	30-34
7683862-13	1993	Chemical modification with group-specific reagents revealed that the integrity of carboxyl groups of the sarcolectin-binding protein and of lysine/arginine groups of sarcolectin are primarily important to maintain binding capacity.	Lysine	140-146	keratin 7	Homo sapiens	166-177
9562653-2	1997	The oxidation involves the degradation of polyunsaturated fatty acids, the formation of lysolecithin, oxysterols and aldehyde modification of lysine residues on Apo B100.	Lysine	142-148	apolipoprotein B	Homo sapiens	161-169
34864207-3	2022	There are indications that OSBP, besides acting as a cholesterol/phosphatidylinositol 4-phosphate (PI4P) exchanger at the endoplasmic reticulum (ER)-trans-Golgi network (TGN) membrane contact sites (MCS), also exchanges these lipids at ER-lysosome (Lys) contacts, increasing Lys cholesterol content.	Lysine	275-278	oxysterol binding protein	Homo sapiens	27-31
34958884-6	2022	The suicide-nanoplasmids were formulated with a targeted K16-lysine domain, analyzed for size, and characterized by electron microscopy.	Lysine	61-67	keratin 16	Mus musculus	57-60
34741939-5	2022	The inhibition of mitochondrial activity and increase in HDAC2 and MTA3 dysregulated the lysine acetylation levels of histone and global proteins.	Lysine	89-95	histone deacetylase 2	Mus musculus	57-62
34497325-2	2022	Polycomb group ring finger protein 1 (Pcgf1) is a component of PRC1.1, a non-canonical PRC1 that monoubiquitylates H2A at lysine 119 (H2AK119ub1).	Lysine	122-128	protein regulator of cytokinesis 1	Mus musculus	87-91
34973392-6	2022	The ATAD2 proteolysis was accompanied by a decrease in the amount of acetylated histone H3 lysine 27 and inhibited cell cycle progression from the early to late S phase under severe hypoxia.	Lysine	91-97	ATPase family AAA domain containing 2	Homo sapiens	4-9
34915417-5	2022	Enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which functions to methylate histone H3 lysine 27 to silence gene transcription.	Lysine	141-147	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34915417-5	2022	Enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which functions to methylate histone H3 lysine 27 to silence gene transcription.	Lysine	141-147	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34896331-11	2022	More importantly, NaB promoted the levels of histone 3 lysine 9 acetylation (H3K9Ac) and histone 3 lysine 27 acetylation (H3K27Ac) at PGC-1alpha promoter region, indicating that NaB promotes PGC-1alpha expression via histone acetylation modification.	Lysine	99-105	PPARG coactivator 1 alpha	Rattus norvegicus	134-144
34896750-0	2022	BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS.	Lysine	39-45	albumin	Homo sapiens	55-68
34939412-3	2022	Based on the previously identified Nepsilon-4-(4-iodophenyl)butanoyl-lysine scaffold, we designed "clickable" lysine-derived albumin binders (cLABs) and determined their dissociation constants toward albumin by novel assay methods.	Lysine	110-116	albumin	Homo sapiens	125-132
34801472-7	2022	Chromatin immunoprecipitation (ChIP) results showed that SETDB1 regulates the expression of Snai1 by catalyzing the histone H3 lysine 9 trimethylation (H3K9me3) of Snai1, the main transcription factor that initiates the process of EMT, and thus, indirectly regulates E-cadherin.	Lysine	127-133	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	57-63
34801472-7	2022	Chromatin immunoprecipitation (ChIP) results showed that SETDB1 regulates the expression of Snai1 by catalyzing the histone H3 lysine 9 trimethylation (H3K9me3) of Snai1, the main transcription factor that initiates the process of EMT, and thus, indirectly regulates E-cadherin.	Lysine	127-133	snail family transcriptional repressor 1	Homo sapiens	92-97
34801472-7	2022	Chromatin immunoprecipitation (ChIP) results showed that SETDB1 regulates the expression of Snai1 by catalyzing the histone H3 lysine 9 trimethylation (H3K9me3) of Snai1, the main transcription factor that initiates the process of EMT, and thus, indirectly regulates E-cadherin.	Lysine	127-133	snail family transcriptional repressor 1	Homo sapiens	164-169
34801472-7	2022	Chromatin immunoprecipitation (ChIP) results showed that SETDB1 regulates the expression of Snai1 by catalyzing the histone H3 lysine 9 trimethylation (H3K9me3) of Snai1, the main transcription factor that initiates the process of EMT, and thus, indirectly regulates E-cadherin.	Lysine	127-133	cadherin 1	Homo sapiens	267-277
34971314-4	2022	In combination with chemical derivatization with fluorenylmethoxycarbonyl chloride to form a hydrophobic conjugate, the developed LC-MS/MS method allows sensitive detection of AP site-Lys cross-links down to sub-1 adduct per 106 nt.	Lysine	184-187	SUB1 regulator of transcription	Homo sapiens	208-213
34939412-3	2022	Based on the previously identified Nepsilon-4-(4-iodophenyl)butanoyl-lysine scaffold, we designed "clickable" lysine-derived albumin binders (cLABs) and determined their dissociation constants toward albumin by novel assay methods.	Lysine	110-116	albumin	Homo sapiens	200-207
34806773-0	2022	Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes.	Lysine	28-34	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	53-59
34843930-2	2022	Enhancer of zeste homology 2 (EZH2), a component of the Polycomb Repressive Complex 2 (PRC2), catalyzes the trimethylation of the downstream gene in the tri-methylates histone three lysine 27 (H3K27me3) position, which causes chromatin pyknosis, and thus, silences the expression of related genes.	Lysine	182-188	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	30-34
34800176-2	2022	The PSMA ligand developed based on the Glu-urea-Lys structure was linked to FITC by aminocaproic acid (Ahx) to obtain PSMA-FITC.	Lysine	48-51	folate hydrolase 1	Homo sapiens	4-8
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Lysine	15-28	poly(ADP-ribose) polymerase 1	Homo sapiens	106-111
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Lysine	15-28	poly(ADP-ribose) polymerase 1	Homo sapiens	121-126
34762160-6	2022	Indeed, recent findings have shown that the characteristic global loss of the repressive histone 3 lysine 27 trimethylation (H3K27me3) mark in PFA ependymoma is caused by aberrant expression of the enhancer of zeste homolog inhibitory protein (EZHIP) or in rare cases by H3K27M mutations, which both inhibit EZH2 thereby preventing the polycomb repressive complex 2 (PRC2) from spreading H3K27me3.	Lysine	99-105	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	308-312
34843930-2	2022	Enhancer of zeste homology 2 (EZH2), a component of the Polycomb Repressive Complex 2 (PRC2), catalyzes the trimethylation of the downstream gene in the tri-methylates histone three lysine 27 (H3K27me3) position, which causes chromatin pyknosis, and thus, silences the expression of related genes.	Lysine	182-188	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-28
34928233-4	2022	AIMS: To explore whether homebox D3 binding to lysine (K)-specific demethylase 5C promoted malignant progression of diffuse large B-cell lymphoma by decreasing p53 expression.	Lysine	47-53	tumor protein p53	Homo sapiens	160-163
34782742-1	2022	Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation.	Lysine	115-121	nuclear receptor binding SET domain protein 2	Homo sapiens	0-48
34782742-1	2022	Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation.	Lysine	115-121	nuclear receptor binding SET domain protein 2	Homo sapiens	50-54
34951099-1	2022	ALKBH4 is a versatile demethylase capable of catalyzing the demethylation of monomethylated lysine-84 on actin and N6 -methyladenine in DNA.	Lysine	92-98	alkB homolog 4, lysine demethylase	Homo sapiens	0-6
34949673-9	2022	Mechanistically, enrichment of PXR and trimethylation of histone 3 lysine 4 (H3K4me3) in the CYP3A4 promoter was increased, and trimethylation of histone 3 lysine 27 (H3K27me3) was decreased after HNF4A-AS1 knockdown.	Lysine	67-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
34949673-9	2022	Mechanistically, enrichment of PXR and trimethylation of histone 3 lysine 4 (H3K4me3) in the CYP3A4 promoter was increased, and trimethylation of histone 3 lysine 27 (H3K27me3) was decreased after HNF4A-AS1 knockdown.	Lysine	67-73	HNF4A antisense RNA 1	Homo sapiens	197-206
34949673-9	2022	Mechanistically, enrichment of PXR and trimethylation of histone 3 lysine 4 (H3K4me3) in the CYP3A4 promoter was increased, and trimethylation of histone 3 lysine 27 (H3K27me3) was decreased after HNF4A-AS1 knockdown.	Lysine	156-162	HNF4A antisense RNA 1	Homo sapiens	197-206
34905354-6	2021	Surprisingly, N6-lactoyl lysine was the major AGE, and based on model incubations, we propose that approximately 90% must be explained by the nonenzymatic acylation of lysine through S-lactoylglutathione, which was quantitated for the first time in meat herein.	Lysine	168-174	renin binding protein	Homo sapiens	46-49
34890965-6	2022	Epigenetic repression of CDK4 and CDK6 by nafamostat mesylate induced apoptosis and suppressed the metastasis of ERPBC through the deacetylation of Histone 3 Lysine 27.	Lysine	158-164	cyclin dependent kinase 6	Homo sapiens	34-38
34964862-4	2022	Mutational analysis identified lysine residue 89 in RMDN3 as a site of ubiquitination by MITOL.	Lysine	31-37	regulator of microtubule dynamics 3	Homo sapiens	52-57
34324684-1	2021	Trimethylation of histone H3 at K9 by the lysine methyltransferase, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) plays a pivotal role in silencing tissue-specific genes and retrotransposable elements.	Lysine	42-48	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	126-132
34928233-16	2022	CONCLUSION: Homebox D3 up-regulating lysine (K)-specific demethylase 5C promotes malignant progression of diffuse large B-cell lymphoma by decreasing p53 expression.	Lysine	37-43	tumor protein p53	Homo sapiens	150-153
34984308-9	2021	Further, lysine acetylation sites and HDAC enzyme prediction revealed the involvement of 15 and 27 potential lysine residues of CREB1 and HINFP, respectively.	Lysine	109-115	histone H4 transcription factor	Homo sapiens	138-143
34904415-5	2021	Mechanistically, our ChIP-seq data showed that ERalpha directly binds to the estrogen response element (ERE) site within the ApoA-I gene and establishes an acetylation of histone 3 lysine 27 (H3K27ac)-enriched chromatin microenvironment.	Lysine	181-187	estrogen receptor 1	Homo sapiens	47-54
34774865-5	2021	The AGE adducts identified at Lys-87 were carboxymethyllysine and carboxyethyllysine, while those detected at Lys-133 included pyrraline-carboxymethyllysine and carboxyethyllysine, respectively.	Lysine	30-33	renin binding protein	Homo sapiens	4-7
34801827-2	2021	In these procedure, p300/CBP could catalyze the acetylation of lysine 27 on histone 3 (H3K27ac), and had been reported to mediate tumorigenesis and development in a variety of tumors by enhancing chromatin transcription activity.	Lysine	63-69	CREB binding protein	Homo sapiens	25-28
34904415-5	2021	Mechanistically, our ChIP-seq data showed that ERalpha directly binds to the estrogen response element (ERE) site within the ApoA-I gene and establishes an acetylation of histone 3 lysine 27 (H3K27ac)-enriched chromatin microenvironment.	Lysine	181-187	apolipoprotein A1	Homo sapiens	125-131
34944023-6	2021	Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappaB and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays.	Lysine	165-171	SET and MYND domain containing 1	Homo sapiens	88-93
34970534-1	2021	Lysyl oxidase-like 2 (LOXL2) is a metalloenzyme that catalyzes the oxidative deamination epsilon-amino group of lysine.	Lysine	112-118	lysyl oxidase like 2	Homo sapiens	0-20
34970534-1	2021	Lysyl oxidase-like 2 (LOXL2) is a metalloenzyme that catalyzes the oxidative deamination epsilon-amino group of lysine.	Lysine	112-118	lysyl oxidase like 2	Homo sapiens	22-27
34944023-6	2021	Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappaB and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays.	Lysine	165-171	interleukin 6	Homo sapiens	208-212
34944023-6	2021	Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappaB and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays.	Lysine	165-171	interleukin 6	Homo sapiens	262-266
34944490-2	2021	LOXL2 catalyzes the oxidative deamination of lysine and hydroxylysine residues in extracellular matrix (ECM) proteins to promote crosslinking of these proteins, and thereby plays a major role in ECM remodeling.	Lysine	45-51	lysyl oxidase like 2	Homo sapiens	0-5
34880421-6	2021	Once freed from PEPD, p53 mutants undergo multiple posttranslational modifications, especially lysine 373 acetylation, which cause them to refold and regain tumor suppressor activities that are typically displayed by p53.	Lysine	95-101	tumor protein p53	Homo sapiens	22-25
34880421-6	2021	Once freed from PEPD, p53 mutants undergo multiple posttranslational modifications, especially lysine 373 acetylation, which cause them to refold and regain tumor suppressor activities that are typically displayed by p53.	Lysine	95-101	tumor protein p53	Homo sapiens	217-220
34880332-6	2021	The nuclear SIRT3 did not act as deacetylase but exerted de-2-hydroxyisobutyrylase activity on lysine residues of histone proteins.	Lysine	95-101	sirtuin 3	Homo sapiens	12-17
34880332-7	2021	Extra-nuclear SIRT3 regulated lysine 2-hydroxyisobutyrylation (Khib) levels of phosphofructokinase (PFK) and Sirt3 deficiency increased PFK Khib levels, inducing a glycolysis boost.	Lysine	30-36	sirtuin 3	Homo sapiens	14-19
34666004-5	2021	The BDR proteins physically interact with FPA,7 one of approximately two dozen genes collectively referred to as the autonomous floral-promotion pathway,8 which are necessary for the repression of the flowering time gene FLOWERING LOCUS C (FLC).9-11 In early-flowering strains, FLC expression is repressed by repressive histone modifications, such as histone H3 lysine 27 trimethylation (H3K27me3), thereby allowing the plants to flower early.	Lysine	362-368	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	221-238
34947995-3	2021	In this study, we investigated the posttranslationally modified p53, including p53 acetylated at lysine 382 (K382), p53 phosphorylated at serine 46 (S46), and the p53 cofactor TTC5/STRAP (Tetratricopeptide repeat domain 5/ Stress-responsive activator of p300-TTC5) proteins in lung cancer.	Lysine	97-103	tumor protein p53	Homo sapiens	79-82
34666004-5	2021	The BDR proteins physically interact with FPA,7 one of approximately two dozen genes collectively referred to as the autonomous floral-promotion pathway,8 which are necessary for the repression of the flowering time gene FLOWERING LOCUS C (FLC).9-11 In early-flowering strains, FLC expression is repressed by repressive histone modifications, such as histone H3 lysine 27 trimethylation (H3K27me3), thereby allowing the plants to flower early.	Lysine	362-368	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	240-243
34666004-5	2021	The BDR proteins physically interact with FPA,7 one of approximately two dozen genes collectively referred to as the autonomous floral-promotion pathway,8 which are necessary for the repression of the flowering time gene FLOWERING LOCUS C (FLC).9-11 In early-flowering strains, FLC expression is repressed by repressive histone modifications, such as histone H3 lysine 27 trimethylation (H3K27me3), thereby allowing the plants to flower early.	Lysine	362-368	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	278-281
34571271-3	2021	In order to interfere with the inhibitory function of FGL1 and PD-L1 proteins, we designed a new type of reactive oxygen species (ROS)-sensitive nanoparticles to load FGL1 siRNA (siFGL1) and PD-L1 siRNA (siPD-L1), which was formed from a stimuli-responsive polymer with a poly-L-lysine-thioketal and modified cis-aconitate to facilitate endosomal escape.	Lysine	272-285	fibrinogen like 1	Sus scrofa	54-58
34792071-2	2021	Modification occurred site-selectively on Lys (>>Ser) residues proximal to the respective aptamer-thrombin interface, was selective for thrombin in the presence of other proteins, and the activity of both DNA-catalysts could be controlled by an external trigger.	Lysine	42-45	coagulation factor II, thrombin	Homo sapiens	98-106
34792071-2	2021	Modification occurred site-selectively on Lys (>>Ser) residues proximal to the respective aptamer-thrombin interface, was selective for thrombin in the presence of other proteins, and the activity of both DNA-catalysts could be controlled by an external trigger.	Lysine	42-45	coagulation factor II, thrombin	Homo sapiens	136-144
34857028-3	2021	Aberrant expression and somatic mutations affecting genes involved in the regulation of tri-methylation of the lysine (K) 27 on histone 3 H3 (H3K27me3) are common in cancer.	Lysine	111-117	H3.4 histone	Homo sapiens	128-140
34862383-4	2021	Among the 20 amino acids, deprivation of glutamine, arginine, methionine, and lysine induced AKT activation.	Lysine	78-84	AKT serine/threonine kinase 1	Homo sapiens	93-96
34648748-3	2021	We show that, when activated in germ cells, HSF-1 recruits MET-2, the putative histone 3 lysine 9 (H3K9) methyltransferase responsible for repressive H3K9me2 (H3K9 dimethyl) marks in chromatin, and negatively bookmarks the insulin receptor daf-2 and other HSF-1 target genes.	Lysine	89-95	Histone-lysine N-methyltransferase met-2	Caenorhabditis elegans	59-64
34571271-3	2021	In order to interfere with the inhibitory function of FGL1 and PD-L1 proteins, we designed a new type of reactive oxygen species (ROS)-sensitive nanoparticles to load FGL1 siRNA (siFGL1) and PD-L1 siRNA (siPD-L1), which was formed from a stimuli-responsive polymer with a poly-L-lysine-thioketal and modified cis-aconitate to facilitate endosomal escape.	Lysine	272-285	CD274 molecule	Sus scrofa	63-68
34571271-3	2021	In order to interfere with the inhibitory function of FGL1 and PD-L1 proteins, we designed a new type of reactive oxygen species (ROS)-sensitive nanoparticles to load FGL1 siRNA (siFGL1) and PD-L1 siRNA (siPD-L1), which was formed from a stimuli-responsive polymer with a poly-L-lysine-thioketal and modified cis-aconitate to facilitate endosomal escape.	Lysine	272-285	fibrinogen like 1	Sus scrofa	167-171
34571271-3	2021	In order to interfere with the inhibitory function of FGL1 and PD-L1 proteins, we designed a new type of reactive oxygen species (ROS)-sensitive nanoparticles to load FGL1 siRNA (siFGL1) and PD-L1 siRNA (siPD-L1), which was formed from a stimuli-responsive polymer with a poly-L-lysine-thioketal and modified cis-aconitate to facilitate endosomal escape.	Lysine	272-285	CD274 molecule	Sus scrofa	191-196
34806925-8	2021	Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	50-77
34676431-0	2021	Lysine reactivity profiling reveals molecular insights into human serum albumin-small-molecule drug interactions.	Lysine	0-6	albumin	Homo sapiens	66-79
34478776-6	2021	A region was revealed within the Abeta sequence, in which proteolytic cleavage (Lys-28) and oxidation (Met-35) lead to a loss of their ability to inhibit the interaction of trypsin with alpha2M.	Lysine	80-83	amyloid beta precursor protein	Homo sapiens	33-38
34806925-8	2021	Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	79-83
34806925-8	2021	Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	97-101
34783291-0	2021	Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.	Lysine	13-19	AKT serine/threonine kinase 1	Homo sapiens	182-185
34783291-0	2021	Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.	Lysine	13-19	mechanistic target of rapamycin kinase	Homo sapiens	186-215
34851506-0	2022	Ezh2 promotes TRbeta lysine methylation-mediated degradation in hepatocellular carcinoma.	Lysine	21-27	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
34455704-0	2021	Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants.	Lysine	40-46	cytochrome c, somatic	Homo sapiens	62-74
34455704-2	2021	Lysine acetylation in particular plays a key role in interactions between respiratory cytochrome c and its metabolic partners.	Lysine	0-6	cytochrome c, somatic	Homo sapiens	86-98
34455704-3	2021	To date, in vivo acetylation of lysines at positions 8 and 53 has specifically been identified in mammalian cytochrome c, but little is known about the structural basis of acetylation-induced functional changes.	Lysine	32-39	cytochrome c, somatic	Homo sapiens	108-120
34661323-4	2021	Toward this goal, the current study generated a mouse line in which lysine 13, which is critical for the nuclear localization of PTEN, is changed to arginine in the lipid-binding domain using the CRISPR-Ca9 gene-editing system.	Lysine	68-74	phosphatase and tensin homolog	Mus musculus	129-133
34455704-4	2021	Here, we independently replaced these two residues in recombinant human cytochrome c with glutamine to mimic lysine acetylation, and then characterized the structure and function of the resulting K8Q and K53Q mutants.	Lysine	109-115	cytochrome c, somatic	Homo sapiens	72-84
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	25-52
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	275-279
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	25-52
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	54-58
34272738-9	2021	RNF5 directly bound to HRD1 and promoted its lysine 48 (K48)- and K33-linked ubiquitination and subsequent proteasomal degradation.	Lysine	45-51	ring finger protein 5	Mus musculus	0-4
34272738-9	2021	RNF5 directly bound to HRD1 and promoted its lysine 48 (K48)- and K33-linked ubiquitination and subsequent proteasomal degradation.	Lysine	45-51	synovial apoptosis inhibitor 1, synoviolin	Mus musculus	23-27
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	275-279
33820450-1	2021	Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription.	Lysine	57-63	bromodomain containing 4	Homo sapiens	0-32
34736895-3	2021	We show here that Rif1 depletion promotes the formation of a unique Zscan4 enhancer structure harboring both histone H3 lysine 27 acetylation (H3K27ac) and moderate levels of silencing chromatin mark H3K9me3.	Lysine	120-126	replication timing regulatory factor 1	Mus musculus	18-22
34396798-2	2021	We are aimed to explore the effects of lysine-specific demethylase 1 (LSD1) in TGF-beta1-treated HK-2 cells and in rats with unilateral ureteral obstruction (UUO), and to investigate the underlying molecular mechanism.	Lysine	39-45	transforming growth factor, beta 1	Rattus norvegicus	79-88
34768127-9	2021	The acetylation level of lysine 142 in HSP90B1 was found to be obvious in the UC colon, and point mutation of HSP90B1-K142ac would result in the decreasing secretion of TNF-alpha and IL-2 in LPS-stimulated cultured cells.	Lysine	25-31	tumor necrosis factor	Mus musculus	169-178
33820450-1	2021	Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription.	Lysine	57-63	bromodomain containing 4	Homo sapiens	34-38
33820450-1	2021	Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription.	Lysine	57-63	defensin beta 1	Homo sapiens	135-138
33820450-1	2021	Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on the N-terminal tails of histones through two bromodomains (BD1 and BD2) to regulate gene transcription.	Lysine	57-63	defensin beta 4A	Homo sapiens	143-146
33820450-5	2021	Co-crystal structures show 3",4",7,8-tetrahydroxyflavone binds to the acetylated lysine binding pocket of BRD4-BD1 or BRD4-BD2, but establishes more interactions with BRD4-BD2 than BRD4-BD1.	Lysine	81-87	bromodomain containing 4	Homo sapiens	106-110
33820450-5	2021	Co-crystal structures show 3",4",7,8-tetrahydroxyflavone binds to the acetylated lysine binding pocket of BRD4-BD1 or BRD4-BD2, but establishes more interactions with BRD4-BD2 than BRD4-BD1.	Lysine	81-87	defensin beta 1	Homo sapiens	111-114
33820450-5	2021	Co-crystal structures show 3",4",7,8-tetrahydroxyflavone binds to the acetylated lysine binding pocket of BRD4-BD1 or BRD4-BD2, but establishes more interactions with BRD4-BD2 than BRD4-BD1.	Lysine	81-87	bromodomain containing 4	Homo sapiens	118-122
33820450-5	2021	Co-crystal structures show 3",4",7,8-tetrahydroxyflavone binds to the acetylated lysine binding pocket of BRD4-BD1 or BRD4-BD2, but establishes more interactions with BRD4-BD2 than BRD4-BD1.	Lysine	81-87	defensin beta 4A	Homo sapiens	123-126
34619345-3	2021	Here, we investigated the function and mechanisms of DHA as a vascular protective agent in DR. DHA exerted its protective effect on vascular injuries in diabetic mice and inhibited cell proliferation and tube formation in human retinal microvascular endothelial cells by decreasing the level of fatty acid synthase (FASN), enhancing the malonylation of mTOR at lysine 1218 (K1218) and attenuating the activation of mTOR complex 1 (mTORC1).	Lysine	361-367	mechanistic target of rapamycin kinase	Homo sapiens	353-357
34376807-1	2021	Enhancer of zeste homolog 2 (EZH2) is a catalytic component of the polycomb repressive complex 2 (PRC2) which reduces gene expression via trimethylation of a lysine residue of histone 3 (H3K27me3).	Lysine	158-164	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34376807-1	2021	Enhancer of zeste homolog 2 (EZH2) is a catalytic component of the polycomb repressive complex 2 (PRC2) which reduces gene expression via trimethylation of a lysine residue of histone 3 (H3K27me3).	Lysine	158-164	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34880642-8	2021	The enrichment of histone H3 lysine 14 acetylation (H3K14ac) and RNA polymerase II (RNA pol II) on HMGB1 promoter was inhibited by the knockdown of KAT7.	Lysine	29-35	lysine acetyltransferase 7	Rattus norvegicus	148-152
34798872-8	2021	Mechanistically, Cb1 enhanced JAK2 ubiquitination and decreased JAK2 and STAT4 expression, where STAT4 improved Runx3 expression by regulating histone H3 lysine 4 trimethylation level.	Lysine	154-160	signal transducer and activator of transcription 4	Rattus norvegicus	97-102
34942999-3	2021	We investigated whether glucose affects lysine-specific demethylase 1 (LSD1) expression and the responsible molecular mechanisms.	Lysine	40-46	lysine (K)-specific demethylase 1A	Mus musculus	71-75
34755724-2	2021	Here, a model LLPS system coupled with a sequential glycolytic enzymatic reaction was developed to reproduce the dynamic control of liquid droplets; (i) the droplets, which consist of poly-L-lysine and nucleotides, compartmentalize two different enzymes (hexokinase and glucose-6-phosphate dehydrogenase) individually, accelerating the overall reaction, and (ii) each enzymatic reaction triggers the formation, dissolution and long-term retention of the droplets by converting the scaffold nucleotides.	Lysine	184-197	hexokinase 1	Homo sapiens	255-265
34798872-8	2021	Mechanistically, Cb1 enhanced JAK2 ubiquitination and decreased JAK2 and STAT4 expression, where STAT4 improved Runx3 expression by regulating histone H3 lysine 4 trimethylation level.	Lysine	154-160	RUNX family transcription factor 3	Rattus norvegicus	112-117
34830351-2	2021	Furthermore, we aimed to characterize a possible interaction between PPARgamma and H3K4me3 (trimethylated lysine 4 of the histone H3), respectively H3K9ac (acetylated lysine 9 of the histone H3), to illuminate the role of histone modifications in a defective trophoblast invasion in preeclampsia (PE).	Lysine	106-112	peroxisome proliferator activated receptor gamma	Homo sapiens	69-78
34371167-4	2021	A macrotheranostic probe (denoted as PLCy) based on conjugating CyNH2 with an acetylated lysine group was developed with masked fluorescence and cytotoxicity, which could both be unmasked through sequential activation by cancer cells overexpressing histone deacetylases (HDACs) and cathepsin L (CTSL) enzymes for selective cancer cell mitochondria-targeted imaging and therapy.	Lysine	89-95	cathepsin L	Homo sapiens	282-293
34748334-4	2021	We demonstrate the strategy by probing the possible transient salt bridge partner of lysine 28 (K28) in the oligomeric states of amyloid beta-40 (Abeta40), the putative toxic species in Alzheimer"s disease.	Lysine	85-91	keratin 28	Homo sapiens	96-99
34767831-4	2022	To investigate this, we examined two independent CKD cohorts for carbamylation of circulating sortilin and detected increased carbamylated sortilin lysine residues in the extracellular domain of sortilin with kidney function decline using targeted mass spectrometry.	Lysine	148-154	sortilin 1	Homo sapiens	139-147
34767831-4	2022	To investigate this, we examined two independent CKD cohorts for carbamylation of circulating sortilin and detected increased carbamylated sortilin lysine residues in the extracellular domain of sortilin with kidney function decline using targeted mass spectrometry.	Lysine	148-154	sortilin 1	Homo sapiens	195-203
34772733-1	2022	Gene expression is regulated by promoters and enhancers marked by histone H3-lysine-27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HATs), EP300 and CBP.	Lysine	77-83	CREB binding protein	Homo sapiens	194-197
34758305-4	2021	We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).	Lysine	24-30	sirtuin 3	Homo sapiens	132-141
34758305-4	2021	We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).	Lysine	24-30	sirtuin 3	Homo sapiens	143-148
34371167-4	2021	A macrotheranostic probe (denoted as PLCy) based on conjugating CyNH2 with an acetylated lysine group was developed with masked fluorescence and cytotoxicity, which could both be unmasked through sequential activation by cancer cells overexpressing histone deacetylases (HDACs) and cathepsin L (CTSL) enzymes for selective cancer cell mitochondria-targeted imaging and therapy.	Lysine	89-95	cathepsin L	Homo sapiens	295-299
34759321-4	2021	This PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with the stable deposition of histone H3 lysine 4 trimethylation by the methyltransferase Set1A (as part of the COMPASS complex (Set1A/COMPASS)).	Lysine	137-143	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	186-191
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	210-216	CREB binding protein	Homo sapiens	237-242
34841684-2	2021	Recently, some particular non-histone proteins have been elucidated to be methylated by SMYD2, a SET and MYND domain protein with lysine methyltransferase activity.	Lysine	130-136	SET and MYND domain containing 2	Mus musculus	88-93
34841684-10	2021	Furthermore, as the lysine-specific demethylase, LSD1 could resist methylation on TRAF2 induced by SMYD2.	Lysine	20-26	lysine (K)-specific demethylase 1A	Mus musculus	49-53
34841684-10	2021	Furthermore, as the lysine-specific demethylase, LSD1 could resist methylation on TRAF2 induced by SMYD2.	Lysine	20-26	SET and MYND domain containing 2	Mus musculus	99-104
34720086-3	2021	Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine (SAM).	Lysine	86-92	cullin 4A	Homo sapiens	49-58
34720086-3	2021	Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine (SAM).	Lysine	86-92	DnaJ heat shock protein family (Hsp40) member A1	Homo sapiens	196-229
34390468-3	2021	To investigate the possible regulatory effects of SUMOylation on TDP-43 activity and trafficking, we first assessed that TDP-43 is SUMO-conjugated in the nuclear compartment both covalently and non-covalently in the RRM1 domain at the predicted lysine 136 and SUMO-interacting motif (SIM, 106-110 residues), respectively.	Lysine	245-251	TAR DNA binding protein	Homo sapiens	121-127
34519605-1	2021	BACKGROUND: Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on histones to facilitate the epigenetic regulation of many genes, and it plays a key role in many cancer types.	Lysine	69-75	bromodomain containing 4	Homo sapiens	12-44
34519605-1	2021	BACKGROUND: Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on histones to facilitate the epigenetic regulation of many genes, and it plays a key role in many cancer types.	Lysine	69-75	bromodomain containing 4	Homo sapiens	46-50
34759321-4	2021	This PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with the stable deposition of histone H3 lysine 4 trimethylation by the methyltransferase Set1A (as part of the COMPASS complex (Set1A/COMPASS)).	Lysine	137-143	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	225-230
34759379-5	2021	In phases also containing RNA polymerase II CTD, many residue types form contacts, including both cation-pi and hydrogen-bonding interactions formed by the conserved human CTD lysines.	Lysine	176-183	CTD	Homo sapiens	172-175
34771652-0	2021	Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis.	Lysine	11-17	L1 cell adhesion molecule	Homo sapiens	42-47
34560329-7	2021	RESULTS: Expression profile of histone methyltransferases in the placentas using quantitative RT-PCR revealed that the mRNA expression levels of histone 3 lysine 4 (H3K4) methyltransferases, SETD1A and SMYD3, were significantly increased in placentas from PE patients.	Lysine	155-161	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	191-197
34725436-1	2021	Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes.	Lysine	54-60	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	5-9
34694864-0	2021	GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.	Lysine	113-119	solute carrier family 8 member A3	Homo sapiens	148-152
34694864-0	2021	GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.	Lysine	113-119	solute carrier family 8 member A3	Homo sapiens	154-174
34769235-2	2021	Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latter of which is supported by structural studies.	Lysine	19-25	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	45-48
34716527-1	2021	BACKGROUND: Kdm6b, a specific histone 3 lysine 27 (H3K27) demethylase, has been reported to be implicated in a variety of developmental processes including cell differentiation and cell fate determination and multiple organogenesis.	Lysine	40-46	lysine (K)-specific demethylase 6B, b	Danio rerio	12-17
34733415-3	2021	Here, for the first time, we elucidate the functional significance of three DVL-1 lysines (K/Lys) which are subject to post-translational acetylation.	Lysine	82-89	dishevelled segment polarity protein 1	Homo sapiens	76-81
34664960-1	2021	The enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-33
34664960-1	2021	The enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	35-39
34698830-7	2022	Moreover, the level of a repressive epigenetic mark, trimethylation of histone H3 at lysine 27 (H3K27me3), was significantly decreased in 4x Col-0 but not in 4x Ler, potentially leading to different transcription levels of FLC and flowering time in 4x Col-0 and 4x Ler.	Lysine	85-91	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	223-226
34764950-2	2021	Our previous work indicated that the enhancer of zeste homolog 2 (Ezh2) is a negative regulator of early NK cell differentiation and function through trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	179-185	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	37-64
34764950-2	2021	Our previous work indicated that the enhancer of zeste homolog 2 (Ezh2) is a negative regulator of early NK cell differentiation and function through trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	179-185	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	66-70
34733415-3	2021	Here, for the first time, we elucidate the functional significance of three DVL-1 lysines (K/Lys) which are subject to post-translational acetylation.	Lysine	93-96	dishevelled segment polarity protein 1	Homo sapiens	76-81
34733415-4	2021	We demonstrate that K34 Lys residue in the DIX domain regulates subcellular localization of beta-catenin, thereby influencing downstream Wnt target gene expression.	Lysine	24-27	keratin 34	Homo sapiens	20-23
34733415-6	2021	Finally, we report that conserved DVL-1 lysines modulate various oncogenic functions such as cell migration, proliferation, cell-cycle progression, 3D-spheroid formation and in-vivo tumor growth in breast cancer models.	Lysine	40-47	dishevelled segment polarity protein 1	Homo sapiens	34-39
34733415-7	2021	Collectively, these findings highlight the importance of DVL-1 domain-specific lysines which were recently shown to be acetylated and characterize their influence on Wnt signaling.	Lysine	79-86	dishevelled segment polarity protein 1	Homo sapiens	57-62
34771469-5	2021	Co-immunoprecipation with EZH2 and pan-methyl lysine antibodies revealed that auto-methylated EZH2 served as a scaffold for binding with methylated NF-kB and Sp1 as well as unmethylated p-STAT3.	Lysine	46-52	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	94-98
34686655-3	2021	To further understand the regulatory mechanism of p38 and oxidative stress in the occurrence and development of gastric cancer, we report SUMOylation as a novel post-translational modification occurring on lysine 152 of MAPK14/p38alpha through immunoprecipitation and series of pull-down assays in vitro and in vivo.	Lysine	206-212	mitogen-activated protein kinase 14	Homo sapiens	50-53
34686655-3	2021	To further understand the regulatory mechanism of p38 and oxidative stress in the occurrence and development of gastric cancer, we report SUMOylation as a novel post-translational modification occurring on lysine 152 of MAPK14/p38alpha through immunoprecipitation and series of pull-down assays in vitro and in vivo.	Lysine	206-212	mitogen-activated protein kinase 14	Homo sapiens	220-226
34686655-3	2021	To further understand the regulatory mechanism of p38 and oxidative stress in the occurrence and development of gastric cancer, we report SUMOylation as a novel post-translational modification occurring on lysine 152 of MAPK14/p38alpha through immunoprecipitation and series of pull-down assays in vitro and in vivo.	Lysine	206-212	mitogen-activated protein kinase 14	Homo sapiens	227-235
34671018-3	2021	Nuclear receptor-binding SET Domain protein 2 (NSD2) is a key histone methyltransferase catalyzing histone H3 lysine 36 dimethylation (H3K36me2).	Lysine	110-116	nuclear receptor binding SET domain protein 2	Homo sapiens	0-45
34671018-3	2021	Nuclear receptor-binding SET Domain protein 2 (NSD2) is a key histone methyltransferase catalyzing histone H3 lysine 36 dimethylation (H3K36me2).	Lysine	110-116	nuclear receptor binding SET domain protein 2	Homo sapiens	47-51
34534290-3	2021	Most of the mutations that suppressed extended HMR-silencing in rpd3 mutants without completely abolishing silencing were identified in the histone H3 lysine 4 methylation (H3K4me) pathway, specifically in SET1, BRE1 and BRE2.	Lysine	151-157	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	64-68
34147909-2	2021	NSD2 catalyzes the methylation of lysine 36 on histone H3 (H3K36me2) and is associated with transcriptionally active regions.	Lysine	34-40	nuclear receptor binding SET domain protein 2	Homo sapiens	0-4
34737746-1	2021	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which regulates downstream gene expression by trimethylation of lysine 27 in histone H3 (H3K27me3).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34737746-1	2021	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which regulates downstream gene expression by trimethylation of lysine 27 in histone H3 (H3K27me3).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34737956-1	2021	The enhancer of zeste homolog 2 (EZH2) is a methylated modification enzyme of Histone H3-Lys 27.	Lysine	89-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	4-31
34737956-1	2021	The enhancer of zeste homolog 2 (EZH2) is a methylated modification enzyme of Histone H3-Lys 27.	Lysine	89-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
34648046-1	2022	PURPOSE: We planned this prospective study to evaluate PSMA expression in recurrent high-grade gliomas (rHGG), including anaplastic astrocytoma and glioblastoma using Glu-NH-CO-NH-Lys-(Ahx)-(Ga-68 (HBED-CC))- (Ga-68 PSMA) positron emission tomography (PET), with its theranostic potential in mind.	Lysine	180-183	folate hydrolase 1	Homo sapiens	55-59
34681759-7	2021	Furthermore, KDM7A overexpression decreased the enrichment of di-methylation of histone H3 lysine 9 (H3K9me2) and H3 lysine 27 (H3K27me2) on the promoter of DGAT2.	Lysine	91-97	diacylglycerol O-acyltransferase 2	Mus musculus	157-162
34681759-7	2021	Furthermore, KDM7A overexpression decreased the enrichment of di-methylation of histone H3 lysine 9 (H3K9me2) and H3 lysine 27 (H3K27me2) on the promoter of DGAT2.	Lysine	117-123	diacylglycerol O-acyltransferase 2	Mus musculus	157-162
34684770-3	2021	Several laboratories applied computational chemistry methods to ultimately conclude that AAI and cannabinoid ligands could overlap within a common binding pocket but that WIN55212-2 primarily utilized steric interactions via aromatic stacking, whereas cannabinoid ligands required some electrostatic interactions, particularly involving the CB1 helix-3 lysine.	Lysine	353-359	cannabinoid receptor 1	Homo sapiens	341-344
34353856-2	2021	SEs are typically characterized by high levels of acetylation of histone H3 lysine 27 (H3K27ac), which is catalyzed by the histone lysine acetyltransferase CREB binding protein (CBP).	Lysine	76-82	CREB binding protein	Homo sapiens	178-181
34722538-5	2021	Here we demonstrate that preventing Drp1 SUMOylation by mutating its SUMO target lysines enhances the Drp1-Bcl-x L interaction in vivo and in vitro.	Lysine	81-88	BCL2 like 1	Homo sapiens	107-114
34761190-2	2021	Thereby, miR-1307 inhibits the expression of KDM3A and KDM3B and increases the methylation modification of histone H3 lysine 9, which enhances the expression of endoplasmic-reticulum-related gene CALR.	Lysine	118-124	microRNA 1307	Homo sapiens	9-17
34761190-2	2021	Thereby, miR-1307 inhibits the expression of KDM3A and KDM3B and increases the methylation modification of histone H3 lysine 9, which enhances the expression of endoplasmic-reticulum-related gene CALR.	Lysine	118-124	calreticulin	Homo sapiens	196-200
34216690-6	2021	Activated PKA upregulates the expression of NF-kappaB subunit c-Rel (REL) and acetylates histone H3 at lysine 9 (H3K9ac) to promote the transcription of SNAIL and SLUG.	Lysine	103-109	snail family transcriptional repressor 1	Homo sapiens	153-158
34644302-9	2021	However, the presence of liposomes strongly abrogated the acylation reaction between succinyl-CoA and TFP lysine residues.	Lysine	106-112	tripartite motif-containing 39	Mus musculus	102-105
34644302-10	2021	Thus, TFP in the membrane-bound state may be protected against lysine acylation.	Lysine	63-69	tripartite motif-containing 39	Mus musculus	6-9
34644302-4	2021	Here, we mapped the known SIRT3/SIRT5-targeted lysine residues onto the recently solved TFP crystal structure which revealed that many of the target sites are involved in substrate channeling within the TFPalpha subunit.	Lysine	47-53	tripartite motif-containing 39	Mus musculus	88-91
34559515-8	2021	Semi-quantification based on integrated peak areas revealed that K186 of TFAM is the major cross-linking residue, consistent with K186 being the closest (to the AP modification) lysine residue in solved TFAM:DNA crystal structures.	Lysine	178-184	transcription factor A, mitochondrial	Homo sapiens	73-77
34559515-8	2021	Semi-quantification based on integrated peak areas revealed that K186 of TFAM is the major cross-linking residue, consistent with K186 being the closest (to the AP modification) lysine residue in solved TFAM:DNA crystal structures.	Lysine	178-184	transcription factor A, mitochondrial	Homo sapiens	203-207
34559515-9	2021	Additional cross-linking lysine residues (K69, K76, K136, K154) support the dynamic characteristics of TFAM:DNA complexes.	Lysine	25-31	transcription factor A, mitochondrial	Homo sapiens	103-107
34696420-8	2021	Finally, E3 ubiquitin ligases for MAVS degradation were screened and identified and RNF5 targeting MAVS at Lysine 363 and 462 was shown to involve in MAVS degradation in aMPV/C-infected Vero cells.	Lysine	107-113	mitochondrial antiviral-signaling protein	Chlorocebus sabaeus	34-38
34696420-8	2021	Finally, E3 ubiquitin ligases for MAVS degradation were screened and identified and RNF5 targeting MAVS at Lysine 363 and 462 was shown to involve in MAVS degradation in aMPV/C-infected Vero cells.	Lysine	107-113	mitochondrial antiviral-signaling protein	Chlorocebus sabaeus	99-103
34696420-8	2021	Finally, E3 ubiquitin ligases for MAVS degradation were screened and identified and RNF5 targeting MAVS at Lysine 363 and 462 was shown to involve in MAVS degradation in aMPV/C-infected Vero cells.	Lysine	107-113	mitochondrial antiviral-signaling protein	Chlorocebus sabaeus	150-154
34606826-2	2021	Zhang and colleagues provide new understanding of memory formation by uncovering the lysine acetyltransferase SRC3 as the key driver of the novel posttranslational modification of calmodulin (CaM) acetylation, which regulates CaM"s activity and subsequent activation of CaMKII.	Lysine	85-91	calmodulin 1	Homo sapiens	180-190
34251718-9	2021	MLL recruits p300/CBP through its transcriptional activation domain, which acetylates histone H3 at lysines 9, 18, and 27.	Lysine	100-107	CREB binding protein	Homo sapiens	18-21
34606826-2	2021	Zhang and colleagues provide new understanding of memory formation by uncovering the lysine acetyltransferase SRC3 as the key driver of the novel posttranslational modification of calmodulin (CaM) acetylation, which regulates CaM"s activity and subsequent activation of CaMKII.	Lysine	85-91	calmodulin 1	Homo sapiens	192-195
34606826-2	2021	Zhang and colleagues provide new understanding of memory formation by uncovering the lysine acetyltransferase SRC3 as the key driver of the novel posttranslational modification of calmodulin (CaM) acetylation, which regulates CaM"s activity and subsequent activation of CaMKII.	Lysine	85-91	calmodulin 1	Homo sapiens	226-229
34795154-3	2021	The alignment of amino acid sequences revealed that 5 Lys residues (K20, K26, K44, K139, and K166) of the 13 Lys residues within NS5A (genotype 2a, JFH1 strain) were conserved compared to those of HCV (genotype 1b, Con1 strain).	Lysine	109-112	keratin 20	Homo sapiens	68-71
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Lysine	14-20	insulin like growth factor 1	Homo sapiens	59-87
34396440-3	2021	The inhibition of WNK lysine deficient protein kinase/STE20/SPS1-related proline/alanine-rich kinase (SPAK) signaling ameliorates cerebral edema, and this signaling pathway regulates the phosphorylation of the downstream Na+-K+-Cl- cotransporter 1 (NKCC1).	Lysine	22-28	serine/threonine kinase 39	Homo sapiens	102-106
34517264-11	2021	Moreover, the inhibition of EZH2 by F2C led to Wnt/beta-catenin signaling inhibition by decreasing tri-methylation of histone H3 at lysine 27 (H3K27me3) and long non-coding RNA H19 expression.	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	28-32
34464854-1	2021	SUV39H1 is a histone methyltransferase involve numerous biological processes, including of aging, embryo development, tumor growth and mitosis via catalysis of dimethylation and trimethylation of lysine 9 of histone H3.	Lysine	196-202	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
34795154-3	2021	The alignment of amino acid sequences revealed that 5 Lys residues (K20, K26, K44, K139, and K166) of the 13 Lys residues within NS5A (genotype 2a, JFH1 strain) were conserved compared to those of HCV (genotype 1b, Con1 strain).	Lysine	54-57	keratin 20	Homo sapiens	68-71
34650566-7	2021	In the antigen-presentation pathway, we observed an association between HLA-DRB1 alleles encoding Lys at residue 71 (mostly DRB1*03:01 and DRB1*04:01) and DOB*01:02 with symptomatic infections and HLA-A alleles encoding 144Q/151R with asymptomatic seronegative women.	Lysine	98-101	major histocompatibility complex, class II, DR beta 1	Homo sapiens	72-80
34650566-7	2021	In the antigen-presentation pathway, we observed an association between HLA-DRB1 alleles encoding Lys at residue 71 (mostly DRB1*03:01 and DRB1*04:01) and DOB*01:02 with symptomatic infections and HLA-A alleles encoding 144Q/151R with asymptomatic seronegative women.	Lysine	98-101	major histocompatibility complex, class II, DR beta 1	Homo sapiens	124-128
34650566-7	2021	In the antigen-presentation pathway, we observed an association between HLA-DRB1 alleles encoding Lys at residue 71 (mostly DRB1*03:01 and DRB1*04:01) and DOB*01:02 with symptomatic infections and HLA-A alleles encoding 144Q/151R with asymptomatic seronegative women.	Lysine	98-101	major histocompatibility complex, class II, DR beta 1	Homo sapiens	139-143
34650566-7	2021	In the antigen-presentation pathway, we observed an association between HLA-DRB1 alleles encoding Lys at residue 71 (mostly DRB1*03:01 and DRB1*04:01) and DOB*01:02 with symptomatic infections and HLA-A alleles encoding 144Q/151R with asymptomatic seronegative women.	Lysine	98-101	major histocompatibility complex, class I, A	Homo sapiens	197-202
34680884-6	2021	Moreover, non-natural lysine substitution at C271 of NSUN2 active site and the subsequent fluorescent labeling was realized through the click reaction.	Lysine	22-28	NOP2/Sun RNA methyltransferase 2	Homo sapiens	53-58
34712915-5	2021	FKBP12 is acetylated on the lysine cluster (K45/K48/K53) by CREB-binding protein (CBP) in mammalian cells in response to nutrient treatment.	Lysine	28-34	paraoxonase 1	Homo sapiens	44-47
34712915-5	2021	FKBP12 is acetylated on the lysine cluster (K45/K48/K53) by CREB-binding protein (CBP) in mammalian cells in response to nutrient treatment.	Lysine	28-34	CREB binding protein	Homo sapiens	60-80
34712915-5	2021	FKBP12 is acetylated on the lysine cluster (K45/K48/K53) by CREB-binding protein (CBP) in mammalian cells in response to nutrient treatment.	Lysine	28-34	CREB binding protein	Homo sapiens	82-85
34685528-2	2021	Herein, we explored the role of enhancer of zeste homolog 2 (EZH2) and its product histone 3 lysine 27 trimethylation (H3K27me3) in high glucose-mediated endothelial inflammation.	Lysine	93-99	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	32-59
34685528-2	2021	Herein, we explored the role of enhancer of zeste homolog 2 (EZH2) and its product histone 3 lysine 27 trimethylation (H3K27me3) in high glucose-mediated endothelial inflammation.	Lysine	93-99	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	61-65
34641382-4	2021	This article reports that d-ribose undergoes rapid protein glycation of human myoglobin (HMb) at lysine residues (K34, K87, K56, and K147) on the protein surface, as identified by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS).	Lysine	97-103	keratin 34	Homo sapiens	114-117
34545456-2	2021	Here, we aimed to discuss the effects of FOXP4-AS1/enhancer of zeste homolog 2 (EZH2)/trimethylation of lysine 27 on histone H3 (H3K27me3)/zinc finger CCCH-type containing 12D (ZC3H12D) axis on HCC.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	41-78
34507491-9	2021	The results suggest that lysines situated within the more rigid structural part of the coat protein provide the chemical environments conducive to radiation brightening, and we discuss some of the characteristics of these environments.	Lysine	25-32	golgi phosphoprotein 3	Homo sapiens	87-99
34373887-6	2021	PSMA-targeting ligands (i.e., glutamate-urea-lysine derivatives called KuEs) and fluorescent or radiolabelled prosthetic groups were grafted onto the UCNP surface by strain-promoted azide-alkyne cycloaddition (SPAAC).	Lysine	45-51	folate hydrolase 1	Homo sapiens	0-4
34545456-2	2021	Here, we aimed to discuss the effects of FOXP4-AS1/enhancer of zeste homolog 2 (EZH2)/trimethylation of lysine 27 on histone H3 (H3K27me3)/zinc finger CCCH-type containing 12D (ZC3H12D) axis on HCC.	Lysine	104-110	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	80-84
34334531-1	2021	We established an IL-2 and IL-4 (IL2/4) - dependent adult T-cell leukemia/lymphoma (ATLL) cell line (YG-PLL) by adding poly-L-lysine (PLL) to the culture medium.	Lysine	119-132	interleukin 2	Homo sapiens	18-22
34573117-0	2021	Glyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Oxidative Damage and Inflammatory Response by Interacting with RAGE.	Lysine	8-14	MOK protein kinase	Mus musculus	128-132
34650699-13	2021	Notably, silencing Nrf2 enhanced the ferroptosis in H9C2 cells induced by OGD/R, while LY, an inhibitor of AKT phosphorylation, diminished the inhibition of Fra.	Lysine	87-89	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
34271259-1	2021	The NSD proteins, namely NSD1, NSD2 and NSD3, are lysine methyltransferases, which catalyze mono- and di-methylation of histone H3K36.	Lysine	50-56	nuclear receptor binding SET domain protein 2	Homo sapiens	31-35
34470819-8	2021	We identified several evolutionary conserved EXO70 lysine residues and experimentally proved their importance for the EXO70A1-phospholipid interactions.	Lysine	51-57	exocyst subunit exo70 family protein A1	Arabidopsis thaliana	118-125
34503512-6	2021	More importantly, TMIGD1 stimulated the Lysine (K40) acetylation of alpha-tubulin and promoted mitotic spindle organization and CRISPR/Cas9-mediated knockout of moesin impaired the TMIGD1-mediated acetylation of alpha-tubulin and filamentous (F)-actin organization.	Lysine	40-46	transmembrane and immunoglobulin domain containing 1	Mus musculus	18-24
34496098-10	2021	LP+0.3% Lys group attenuated the effects of LP diet on the expression of MSTN, WWP1, IGF1, P-P70S6K1, P-4EBP1 and P-S6 (p < 0.05).	Lysine	8-11	growth/differentiation factor 8	Oryctolagus cuniculus	73-77
34493753-3	2021	EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 that methylates lysine 27 on histone 3 (H3K27me3).	Lysine	83-89	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
34618146-5	2021	We show that Arabidopsis MORF-RELATED GENE (MRG) proteins, components of the NuA4 histone acetyltransferase complex that bind trimethylated-lysine 36 in histone H3 (H3K36me3), function as a chromatin switch on the floral integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) to coordinate flowering initiation with plant responsiveness to hostile environments.	Lysine	140-146	AGAMOUS-like 20	Arabidopsis thaliana	232-274
34482698-6	2021	Three PTH1-34 variants were generated by substituting two of the three lysine (Lys) residues with arginine, reserving a single Lys as the modification site in each sequence.	Lysine	71-77	parathyroid hormone	Homo sapiens	6-10
34482698-6	2021	Three PTH1-34 variants were generated by substituting two of the three lysine (Lys) residues with arginine, reserving a single Lys as the modification site in each sequence.	Lysine	79-82	parathyroid hormone	Homo sapiens	6-10
34618146-5	2021	We show that Arabidopsis MORF-RELATED GENE (MRG) proteins, components of the NuA4 histone acetyltransferase complex that bind trimethylated-lysine 36 in histone H3 (H3K36me3), function as a chromatin switch on the floral integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) to coordinate flowering initiation with plant responsiveness to hostile environments.	Lysine	140-146	AGAMOUS-like 20	Arabidopsis thaliana	276-280
34378541-1	2021	Acetylation of NF-kappaB"s RelA subunit at lysine-310 (AcLys310) helps to maintain constitutive NF-kappaB activity in cancers such as triple-negative breast cancer (TNBC).	Lysine	43-49	nuclear factor kappa B subunit 1	Homo sapiens	15-24
34431717-5	2021	NLRP3 is modified by lysine-63 ubiquitin chains in hepatocytes and is deubiquitinated during HCV infection.	Lysine	21-27	NLR family pyrin domain containing 3	Homo sapiens	0-5
34342229-7	2021	Together, our studies suggest that a KCTD2-KCTD5-CUL3-RING E3 ligase recruits Gbetagamma in response to signaling, monoubiquitinates lysine-23 within Gbeta1/2, and regulates Gbetagamma effectors to modulate downstream signal transduction.	Lysine	133-139	potassium channel tetramerization domain containing 5	Homo sapiens	43-48
34378541-1	2021	Acetylation of NF-kappaB"s RelA subunit at lysine-310 (AcLys310) helps to maintain constitutive NF-kappaB activity in cancers such as triple-negative breast cancer (TNBC).	Lysine	43-49	nuclear factor kappa B subunit 1	Homo sapiens	96-105
34224364-0	2021	VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases.	Lysine	113-119	poly(ADP-ribose) polymerase 1	Homo sapiens	61-65
34465286-1	2021	BACKGROUND: Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been identified as a histone 3 lysine 27 (H3K27) demethylase and acted as a tumor suppressor gene or oncogenic function.	Lysine	119-125	lysine demethylase 6A	Homo sapiens	79-82
34383980-3	2021	Here, we demonstrate that Nor1 is a non-conventional target of SUMO2/3 conjugation at Lys-137 contained in an atypic psiKxSP motif referred to as the pSuM.	Lysine	86-89	nuclear receptor subfamily 4 group A member 3	Homo sapiens	26-30
34383980-3	2021	Here, we demonstrate that Nor1 is a non-conventional target of SUMO2/3 conjugation at Lys-137 contained in an atypic psiKxSP motif referred to as the pSuM.	Lysine	86-89	small ubiquitin-like modifier 2	Mus musculus	63-70
34497368-0	2021	TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.	Lysine	44-50	tripartite motif containing 15	Homo sapiens	0-6
34497368-0	2021	TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.	Lysine	44-50	mitogen-activated protein kinase 1	Homo sapiens	25-28
34497368-3	2021	Here, we show that ERK1/2 are also modified by lysine-63 (K63)-linked polyubiquitin chains.	Lysine	47-53	mitogen-activated protein kinase 1	Homo sapiens	19-25
34497368-5	2021	TRIM15 and CYLD regulate ERK ubiquitination at defined lysine residues through mutually exclusive interactions as well as opposing activities.	Lysine	55-61	tripartite motif containing 15	Homo sapiens	0-6
34497368-5	2021	TRIM15 and CYLD regulate ERK ubiquitination at defined lysine residues through mutually exclusive interactions as well as opposing activities.	Lysine	55-61	mitogen-activated protein kinase 1	Homo sapiens	25-28
34433666-10	2021	As an underlying mechanism, we showed TRIM47-dependent lysine 27-linked polyubiquitination of PKC-epsilon.	Lysine	55-61	tripartite motif containing 47	Homo sapiens	38-44
34119876-7	2021	Mechanistically, SAHH inhibition increased TXNIP by inhibiting histone methyltransferase enhancer of zeste homolog 2 (EZH2) and reduced trimethylation of histone H3 lysine 27 and its enrichment at promoter of early growth response 1 (EGR1).	Lysine	165-171	thioredoxin interacting protein	Mus musculus	43-48
34385547-2	2021	The only known post-translational modification of Api5 is acetylation at lysine 251 (K251).	Lysine	73-79	apoptosis inhibitor 5	Homo sapiens	50-54
34500733-1	2021	Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked to the development of acute leukemias characterized by the MLL (mixed-lineage leukemia) rearrangements (MLLr cells).	Lysine	88-94	DOT1 like histone lysine methyltransferase	Homo sapiens	0-31
34419497-3	2021	We found that AKT transcription signaling was a target pathway via miR-26a-mediated deacetylation modification of Ras-responsive element-binding protein 1 (RREB1) at the Lys-60 residue.	Lysine	170-173	AKT serine/threonine kinase 1	Homo sapiens	14-17
34406978-10	2021	Inhibition of circRHOT1 reduced the enrichment of transcription active marker histone H3 lysine 27 acetylation (H3K27ac) and RNA polymerase II on the promoter of c-MYC.	Lysine	89-95	ras homolog family member T1	Homo sapiens	14-23
34217716-10	2021	Acetylation of lysine at positions K298, K302 and K326 of C/EBP-alpha promotes its binding to Beclin1.	Lysine	15-21	CCAAT enhancer binding protein alpha	Homo sapiens	58-69
34385547-5	2021	Our studies suggest that acetylation of Api5 at lysine 251 is mediated by p300 histone acetyltransferase while de-acetylation is carried out by HDAC1.	Lysine	48-54	apoptosis inhibitor 5	Homo sapiens	40-44
34440561-2	2021	SETDB1 is widely expressed in human tissues, methylating Histone 3 lysine 9 (H3K9) residues, promoting chromatin compaction and exerting negative regulation on gene expression.	Lysine	67-73	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	0-6
34372908-4	2021	Enhancer of Zeste EZH2 is the catalytic subunit of the complex that is able to trimethylate lysine 27 of histone H3 and induce silencing of the involved genes.	Lysine	92-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	18-22
34132576-6	2021	Mutational and sequence analysis revealed conserved lysine/arginine residues at positions 49/50 and 91 of betaC1 proteins to be essential for their ATPase activity.	Lysine	52-58	adenylate cyclase 1	Homo sapiens	106-112
34132576-16	2021	The lysine/arginine residues conserved at positions 49 and 91 of betaC1 were found to be crucial for its ATPase function.	Lysine	4-10	adenylate cyclase 1	Homo sapiens	65-71
34224210-4	2021	Here, we show that serine 32-36 phosphorylation of IkappaBalpha favors its binding to nucleosomes and demonstrate that p-IkappaBalpha association with H4 depends on the acetylation of specific H4 lysine residues.	Lysine	196-202	NFKB inhibitor alpha	Homo sapiens	51-63
34224210-4	2021	Here, we show that serine 32-36 phosphorylation of IkappaBalpha favors its binding to nucleosomes and demonstrate that p-IkappaBalpha association with H4 depends on the acetylation of specific H4 lysine residues.	Lysine	196-202	NFKB inhibitor alpha	Homo sapiens	121-133
34111434-7	2021	In a term of mechanism, BAG3 epigenetically regulated GALNT10 transactivation via histone H3 lysine 4 (H3K4) presenter WDR5.	Lysine	93-99	BAG cochaperone 3	Homo sapiens	24-28
34440160-4	2021	In this review, we describe the studies performed on the main modifications affecting the activity of STAT3: phosphorylation of tyrosine 705 and serine 727; acetylation of lysine 49, 87, 601, 615, 631, 685, 707, and 709; and methylation of lysine 49, 140, and 180.	Lysine	172-178	signal transducer and activator of transcription 3	Homo sapiens	102-107
34440160-4	2021	In this review, we describe the studies performed on the main modifications affecting the activity of STAT3: phosphorylation of tyrosine 705 and serine 727; acetylation of lysine 49, 87, 601, 615, 631, 685, 707, and 709; and methylation of lysine 49, 140, and 180.	Lysine	240-246	signal transducer and activator of transcription 3	Homo sapiens	102-107
34618105-4	2021	Here, we show that H3.3 upregulates FLC expression and promotes active histone modifications histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at the FLC locus.	Lysine	153-159	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	196-199
34111434-7	2021	In a term of mechanism, BAG3 epigenetically regulated GALNT10 transactivation via histone H3 lysine 4 (H3K4) presenter WDR5.	Lysine	93-99	WD repeat domain 5	Homo sapiens	119-123
34244292-4	2021	Mutations of two SUMO-acceptor lysines of Satb2 (Satb2 K  R ) or knockout of Zfp451 impair the ability of ESCs to silence pluripotency genes and activate differentiation-associated genes in response to retinoic acid (RA) treatment.	Lysine	31-38	SATB homeobox 2	Homo sapiens	42-47
34385569-8	2021	Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1alpha promoter region and thus inhibited the methylation of HIF1alpha to promote HIF1alpha expression, thus upregulating DDIT4 and activating the mTOR signaling pathway.	Lysine	62-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-112
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	histone methyltransferase DOT1	Saccharomyces cerevisiae S288C	99-104
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	histone demethylase	Saccharomyces cerevisiae S288C	141-146
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	histone demethylase GIS1	Saccharomyces cerevisiae S288C	159-164
34169322-9	2021	SP2509-mediated inhibition of STAT3 phosphorylation is dependent on its original target lysine-specific demethylase 1 in cancer cells.	Lysine	88-94	signal transducer and activator of transcription 3	Homo sapiens	30-35
34746802-1	2021	A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells.	Lysine	53-59	cripto, FRL-1, cryptic family 1	Homo sapiens	119-126
34512145-2	2021	Enhancer of zeste homolog 2 (EZH2) is the key catalytic component of Polycomb repressive complex 2 (PRC2) that mediates the tri-methylation of lysine 27 on histone 3 (H3K27me3), a well-recognized marker of transcriptional repression.	Lysine	143-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34313586-3	2021	In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis.	Lysine	144-150	dihydrodipicolinate synthase 1	Arabidopsis thaliana	54-82
34313586-3	2021	In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis.	Lysine	144-150	dihydrodipicolinate synthase 1	Arabidopsis thaliana	84-89
34512145-2	2021	Enhancer of zeste homolog 2 (EZH2) is the key catalytic component of Polycomb repressive complex 2 (PRC2) that mediates the tri-methylation of lysine 27 on histone 3 (H3K27me3), a well-recognized marker of transcriptional repression.	Lysine	143-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34440470-2	2021	NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and dimethylated lysine on histone H3.	Lysine	170-176	nuclear receptor binding SET domain protein 2	Homo sapiens	126-130
34301959-7	2021	Substitution of basally-acetylated intracellular lysine residues identified on PANX1 by mass spectrometry either prevents HDAC6-mediated activation (K140/409Q) or renders the channels constitutively active (K140R).	Lysine	49-55	histone deacetylase 6	Homo sapiens	122-127
34301959-8	2021	These data define a non-canonical RhoA-mDia-HDAC6 signaling pathway for GalphaqPCR activation of PANX1 channels and uncover lysine acetylation-deacetylation as an ion channel silencing-activation mechanism.	Lysine	124-130	ras homolog family member A	Homo sapiens	34-38
34255515-1	2021	CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development.	Lysine	55-61	CREB binding protein	Homo sapiens	0-6
34255515-1	2021	CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development.	Lysine	55-61	CREB binding protein	Homo sapiens	8-11
34255515-1	2021	CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development.	Lysine	55-61	CREB binding protein	Homo sapiens	12-17
34255515-3	2021	The bromodomains of CREBBP and EP300 enable the binding of acetylated lysine residues from histones and a number of other important proteins, including p53, p73, E2F, and GATA1.	Lysine	70-76	CREB binding protein	Homo sapiens	20-26
34255515-3	2021	The bromodomains of CREBBP and EP300 enable the binding of acetylated lysine residues from histones and a number of other important proteins, including p53, p73, E2F, and GATA1.	Lysine	70-76	tumor protein p53	Homo sapiens	152-155
34255515-3	2021	The bromodomains of CREBBP and EP300 enable the binding of acetylated lysine residues from histones and a number of other important proteins, including p53, p73, E2F, and GATA1.	Lysine	70-76	GATA binding protein 1	Homo sapiens	171-176
34290256-4	2021	Among these are RNF20 and RNF40, which form a complex that monoubiquitinates H2B on lysine 120.	Lysine	84-90	ring finger protein 20	Homo sapiens	16-21
34290256-4	2021	Among these are RNF20 and RNF40, which form a complex that monoubiquitinates H2B on lysine 120.	Lysine	84-90	ring finger protein 40	Homo sapiens	26-31
34360011-1	2021	Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking between Gln and Lys residues and involved in various pathophysiological events.	Lysine	104-107	transglutaminase 2	Homo sapiens	0-18
34285233-6	2021	Specifically, MARCH8 catalyzes the K63-linked polyubiquitination of M2 at lysine residue 78 (K78).	Lysine	74-80	keratin 78	Homo sapiens	93-96
34272458-6	2021	We found a higher association of VCAM-1 gene with active histone H3 trimethylated on lysine 4, leading to increased NF-kappaB accessibility in senescent ECs.	Lysine	85-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
34270461-7	2021	Mechanically, upon interaction with p53, BMI1 was recruited on the promoter of miR-3682-3p gene concomitant with an increase in the mono-ubiquitination of histone H2A lysine 119, leading to transcription repression of miR-3682-3p gene followed by derepression of ABCB1 (ATP binding cassette subfamily B member 1) gene.	Lysine	167-173	tumor protein p53	Homo sapiens	36-39
34357075-1	2021	SUV39H1 and SUV39H2 were the first protein lysine methyltransferases that were identified more than 20 years ago.	Lysine	43-49	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
34358125-2	2021	EZH2 (Enhancer of zeste homolog 2), a catalytic component of polycomb repressive complex 2 (PRC2), methylates lysine 27 of histone H3 to promote transcriptional silencing and is an important drug target for controlling cancer via epigenetic processes.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
34358125-2	2021	EZH2 (Enhancer of zeste homolog 2), a catalytic component of polycomb repressive complex 2 (PRC2), methylates lysine 27 of histone H3 to promote transcriptional silencing and is an important drug target for controlling cancer via epigenetic processes.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	6-33
34273022-3	2022	Synthesis of hypusine involves two enzymatic steps: first, deoxyhypusine synthase (DHPS) cleaves the 4-aminobutyl moiety of spermidine and transfers it to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form an intermediate, deoxyhypusine (Nepsilon-(4-aminobutyl)lysine).	Lysine	193-199	deoxyhypusine synthase	Homo sapiens	59-81
34273022-3	2022	Synthesis of hypusine involves two enzymatic steps: first, deoxyhypusine synthase (DHPS) cleaves the 4-aminobutyl moiety of spermidine and transfers it to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form an intermediate, deoxyhypusine (Nepsilon-(4-aminobutyl)lysine).	Lysine	193-199	deoxyhypusine synthase	Homo sapiens	83-87
34162724-0	2021	Linear Ubiquitination of RIPK1 on Lys 612 Regulates Systemic Inflammation via Preventing Cell Death.	Lysine	34-37	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	25-30
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Lysine	207-213	tumor protein p53	Homo sapiens	57-60
34367411-2	2021	We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues.	Lysine	147-153	ETS variant transcription factor 1	Homo sapiens	20-24
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Lysine	207-213	tumor protein p53	Homo sapiens	222-225
34345216-9	2021	Results: This study proved that IGF2BP2 mainly binds to SUMO1 and was SUMOylated at the lysine residues K497, K505 and K509 sites, which can be reduced by SENP1.	Lysine	88-94	insulin-like growth factor 2 mRNA binding protein 2	Mus musculus	32-39
34257278-3	2021	Moreover, IFN-beta also induces TRIM21 ISGylation at multiple lysine residues, thereby enhancing its E3 ligase activity for K63-linkage-specific ubiquitination and resulting in increased levels of TRIM21 and p62 K63-linked ubiquitination.	Lysine	62-68	IFN1@	Homo sapiens	10-18
34257278-3	2021	Moreover, IFN-beta also induces TRIM21 ISGylation at multiple lysine residues, thereby enhancing its E3 ligase activity for K63-linkage-specific ubiquitination and resulting in increased levels of TRIM21 and p62 K63-linked ubiquitination.	Lysine	62-68	tripartite motif containing 21	Homo sapiens	32-38
34345216-9	2021	Results: This study proved that IGF2BP2 mainly binds to SUMO1 and was SUMOylated at the lysine residues K497, K505 and K509 sites, which can be reduced by SENP1.	Lysine	88-94	small ubiquitin-like modifier 1	Mus musculus	56-61
34564982-11	2021	Mechanistically, HOCX13-AS1 augmented FZD through cAMP-response element binding protein-binding protein (CBP)-modulated histone H3 on lysine 27 acetylation (H3K27ac).	Lysine	134-140	CREB binding protein	Homo sapiens	50-103
34244482-4	2021	Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by inducing transcription of the deacetylase sirtuin 3 (SIRT3).	Lysine	107-113	sirtuin 3	Homo sapiens	167-176
34230470-4	2021	We show that ERG is methylated by Enhancer of zest homolog 2 (EZH2) at a specific lysine residue (K362) located within the internal auto-inhibitory domain.	Lysine	82-88	ETS transcription factor ERG	Homo sapiens	13-16
34230470-4	2021	We show that ERG is methylated by Enhancer of zest homolog 2 (EZH2) at a specific lysine residue (K362) located within the internal auto-inhibitory domain.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-60
34230470-4	2021	We show that ERG is methylated by Enhancer of zest homolog 2 (EZH2) at a specific lysine residue (K362) located within the internal auto-inhibitory domain.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	62-66
34356841-9	2021	Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310.	Lysine	272-275	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	235-244
34215314-1	2021	BACKGROUND: The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming.	Lysine	27-33	DOT1 like histone lysine methyltransferase	Homo sapiens	63-68
34143514-0	2021	Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.	Lysine	24-30	SET and MYND domain containing 2	Mus musculus	18-23
34143514-1	2021	SET and MYND domain protein 2 (SMYD2) is a lysine methyltransferase that mediates histone H3 lysine 36 trimethylation (H3K36me3) and acts as a regulator of tumorgenesis and cystic growth.	Lysine	93-99	SET and MYND domain containing 2	Mus musculus	0-29
34143514-1	2021	SET and MYND domain protein 2 (SMYD2) is a lysine methyltransferase that mediates histone H3 lysine 36 trimethylation (H3K36me3) and acts as a regulator of tumorgenesis and cystic growth.	Lysine	93-99	SET and MYND domain containing 2	Mus musculus	31-36
34244427-7	2021	Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation.	Lysine	169-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	192-201
34244482-4	2021	Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by inducing transcription of the deacetylase sirtuin 3 (SIRT3).	Lysine	107-113	sirtuin 3	Homo sapiens	178-183
34244565-5	2021	Reciprocally, SIRT6 also deacetylated CDH1 at lysine K135 and promoted its degradation, resulting in an increase in APC/C-CDH1-targeted substrates, dysfunction in centrosome amplification, and chromosome instability.	Lysine	46-52	cadherin 1	Homo sapiens	38-42
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	long intergenic non-protein coding RNA 525	Homo sapiens	17-26
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	82-139
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	141-145
34564982-11	2021	Mechanistically, HOCX13-AS1 augmented FZD through cAMP-response element binding protein-binding protein (CBP)-modulated histone H3 on lysine 27 acetylation (H3K27ac).	Lysine	134-140	CREB binding protein	Homo sapiens	105-108
34155378-2	2021	Here, we use genome-wide mutagenesis to identify genes involved in HIF transcriptional activity, and define a requirement for the histone H3 lysine 4 (H3K4) methyltransferase SET1B.	Lysine	141-147	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	175-180
34326168-9	2021	Mechanistically, WARS tryptophanylated lysine 1136 of and activated E3 ligase TRIP12 to degrade NFATc1, a PD-1 transcription activator.	Lysine	39-45	tryptophanyl-tRNA synthetase 1	Homo sapiens	17-21
34295118-2	2021	They show mutations resulting in replacement of lysine at position 27 by methionine (K27M) of histone genes, H3F3A , HIST1H3B, and HIST1H3C.	Lysine	48-54	H3 clustered histone 2	Homo sapiens	117-125
34137174-4	2021	At the centre of the pathway is the mono-ubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues.	Lysine	110-116	FA complementation group I	Homo sapiens	87-92
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	82-86
34155106-3	2021	Here, we study a prototype for these receptors, a DAP12-NKG2C 2:1 heterotrimeric complex, in which the two DAP12 subunits each contribute a single transmembrane Asp residue, and the NKG2C subunit contributes a Lys to form the complex.	Lysine	210-213	killer cell lectin like receptor C2	Homo sapiens	182-187
34209110-1	2021	Positively charged groups that mimic arginine or lysine in a natural substrate of trypsin are necessary for drugs to inhibit the trypsin-like serine protease TMPRSS2 that is involved in the viral entry and spread of coronaviruses, including SARS-CoV-2.	Lysine	49-55	transmembrane serine protease 2	Homo sapiens	158-165
34249418-8	2021	LncRNA RP11-367G18.1 specifically regulates the histone 4 lysine 16 acetylation (H4K16Ac) mark that is located on the promoters of two "core" EMT regulators, Twist1 and SLUG, and VEGF genes.	Lysine	58-64	twist family bHLH transcription factor 1	Homo sapiens	158-164
34220336-2	2021	This study determined whether altered trimethylation of histone 3 at lysine 4 (H3K4me3) in the promoter of the tumor necrosis factor-alpha (tnf-alpha) gene with neural cell apoptosis was involved in the ventral-medial striatum, an important brain region for withdrawal symptoms, of neonatal rat offspring from morphine-addicted mothers.	Lysine	69-75	tumor necrosis factor	Rattus norvegicus	111-138
34220336-2	2021	This study determined whether altered trimethylation of histone 3 at lysine 4 (H3K4me3) in the promoter of the tumor necrosis factor-alpha (tnf-alpha) gene with neural cell apoptosis was involved in the ventral-medial striatum, an important brain region for withdrawal symptoms, of neonatal rat offspring from morphine-addicted mothers.	Lysine	69-75	tumor necrosis factor	Rattus norvegicus	140-149
34249418-8	2021	LncRNA RP11-367G18.1 specifically regulates the histone 4 lysine 16 acetylation (H4K16Ac) mark that is located on the promoters of two "core" EMT regulators, Twist1 and SLUG, and VEGF genes.	Lysine	58-64	vascular endothelial growth factor A	Homo sapiens	179-183
34107997-8	2021	In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation.	Lysine	81-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	186-195
34200910-2	2021	We identified lysine residues (K67, K141, and K166) that are involved in the ubiquitination of human growth hormone (hGH) using ubiquitination site prediction programs to validate the ubiquitination sites, and then substituted these lysine residues with arginine residues.	Lysine	14-20	growth hormone 1	Homo sapiens	101-115
34099628-3	2021	NSD1 is a H3K36 (histone H3 at lysine 36) methyltransferase.	Lysine	31-37	nuclear receptor-binding SET-domain protein 1	Mus musculus	0-4
34201346-1	2021	The CREB-binding protein (CBP) and p300 are two paralogous lysine acetyltransferases (KATs) that were discovered in the 1980s-1990s.	Lysine	59-65	CREB binding protein	Homo sapiens	4-24
34201346-1	2021	The CREB-binding protein (CBP) and p300 are two paralogous lysine acetyltransferases (KATs) that were discovered in the 1980s-1990s.	Lysine	59-65	CREB binding protein	Homo sapiens	26-29
34103516-7	2021	Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation.	Lysine	153-159	heat shock transcription factor A2	Arabidopsis thaliana	57-62
34081570-1	2021	Lysine demethylase 3B (KDM3B) gene is a histone demethylase, demonstrating specific demethylation of the histone H3 lysine 9.	Lysine	116-122	lysine-specific demethylase 3B	Ovis aries	0-21
34200465-4	2021	Here, we show that histone H3 lysine 4 trimethylation (H3K4me3) at HSP21 was maintained at high levels for at least three days in response to heat.	Lysine	30-36	heat shock protein 21	Arabidopsis thaliana	67-72
34164392-2	2021	The histone lysine methyltransferase SETD1A, which specifically methylates histone 3 lysine 4 (H3K4), is involved in tumor growth and metastasis, and its ectopic expression has been detected in aggressive malignancies.	Lysine	85-91	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	37-43
34081570-1	2021	Lysine demethylase 3B (KDM3B) gene is a histone demethylase, demonstrating specific demethylation of the histone H3 lysine 9.	Lysine	116-122	lysine-specific demethylase 3B	Ovis aries	23-28
34101139-1	2021	BACKGROUND AND OBJECTIVE: In end-stage kidney disease, high urea levels promote the carbamylation of lysine side chains on a variety of proteins, including albumin.	Lysine	101-107	albumin	Homo sapiens	156-163
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	jumonji domain containing 1C	Homo sapiens	83-89
34108663-2	2021	DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation of a single lysine (K1268) by the CRL4CSA ubiquitin ligase.	Lysine	138-144	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	61-64
34071322-1	2021	Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in CREBBP or EP300 genes encoding CBP/p300 lysine acetyltransferases.	Lysine	134-140	CREB binding protein	Homo sapiens	94-100
34071322-1	2021	Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in CREBBP or EP300 genes encoding CBP/p300 lysine acetyltransferases.	Lysine	134-140	CREB binding protein	Homo sapiens	125-129
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	protein arginine methyltransferase 5	Homo sapiens	131-136
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	protein arginine methyltransferase 5	Homo sapiens	293-298
34113620-6	2021	Our results demonstrate that PRMT5 regulates spermatogonial stem cell development by modulating histone H3 lysine modifications.	Lysine	107-113	protein arginine methyltransferase 5	Homo sapiens	29-34
34069776-0	2021	The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development.	Lysine	4-10	SET and MYND domain containing 3	Danio rerio	21-26
34079475-4	2021	Histone modification by lysine acetylation is another major epigenetic mechanism associated with gene regulation.	Lysine	24-30	H2B clustered histone 1	Rattus norvegicus	0-7
34079475-5	2021	Equilibrium between the activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) determine the level of lysine acetylation.	Lysine	128-134	H2B clustered histone 1	Rattus norvegicus	38-45
34067816-5	2021	Among all samples, the MSTN rs1805086 Lys(K) allele was the most common form in both groups.	Lysine	38-41	myostatin	Homo sapiens	23-27
34079475-5	2021	Equilibrium between the activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) determine the level of lysine acetylation.	Lysine	128-134	H2B clustered histone 1	Rattus norvegicus	76-83
34079475-11	2021	These findings demonstrate that lysine acetylation of histone and non-histone proteins is an early epigenetic mechanism associated with sympathetic nerve activation and hypertension in rodent models of IH.	Lysine	32-38	H2B clustered histone 1	Rattus norvegicus	54-61
34079475-11	2021	These findings demonstrate that lysine acetylation of histone and non-histone proteins is an early epigenetic mechanism associated with sympathetic nerve activation and hypertension in rodent models of IH.	Lysine	32-38	H2B clustered histone 1	Rattus norvegicus	70-77
34141456-2	2021	Here, we aimed to discuss the role of lncRNA interleukin enhancer-binding factor 3-antisense RNA 1 (ILF3-AS1)/enhancer of zeste homolog 2 (EZH2)/cyclin-dependent kinase inhibitor 2 (CDKN2A)/histone 3 (H3) lysine 27 trimethylation (H3K27me3) in cell proliferation and metastasis of CRC.	Lysine	205-211	arylsulfatase B	Mus musculus	105-108
34094676-1	2021	EZH2 is an enzymatic subunit of PRC2, an epigenetic regulator that triggers the methylation of the histone H3 lysine 27 silencing the transcription of several genes.	Lysine	110-116	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
34142031-4	2021	Global lysine propionylation analysis of the intestinal samples showed that Sod2 was propionylated at lysine 132 (K132), and further biochemical assays demonstrated that K132 propionylation suppressed Sod2 activity.	Lysine	7-13	superoxide dismutase 2, mitochondrial	Danio rerio	76-80
34142031-4	2021	Global lysine propionylation analysis of the intestinal samples showed that Sod2 was propionylated at lysine 132 (K132), and further biochemical assays demonstrated that K132 propionylation suppressed Sod2 activity.	Lysine	102-108	superoxide dismutase 2, mitochondrial	Danio rerio	76-80
34065631-1	2021	Enhancer of zeste homolog 2 (EZH2) is a methyltransferase to mediate lysine 27 trimethylation in histone H3 (i.e., H3K27me3) and repress gene expression.	Lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
34065631-1	2021	Enhancer of zeste homolog 2 (EZH2) is a methyltransferase to mediate lysine 27 trimethylation in histone H3 (i.e., H3K27me3) and repress gene expression.	Lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
34141456-2	2021	Here, we aimed to discuss the role of lncRNA interleukin enhancer-binding factor 3-antisense RNA 1 (ILF3-AS1)/enhancer of zeste homolog 2 (EZH2)/cyclin-dependent kinase inhibitor 2 (CDKN2A)/histone 3 (H3) lysine 27 trimethylation (H3K27me3) in cell proliferation and metastasis of CRC.	Lysine	205-211	cyclin dependent kinase inhibitor 2A	Mus musculus	182-188
34723236-5	2021	Methods: Due to the absence of arginine and lysine residues in C-peptide, we utilized Glu-C as the proteolytic enzyme in the method.	Lysine	44-50	insulin	Homo sapiens	63-72
34401209-7	2021	The effects of lncRNA H19 on hDPSCs were achieved by repressing LATS1 through enhancer of zeste homolog 2-induced trimethylation of histone 3 at lysine 27.	Lysine	145-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	78-105
34973011-2	2021	In previous work, we reported that the circadian transcription factor CLOCK and its heterodimer partner BMAL1 suppress the transcriptional activity of the glucocorticoid receptor (GR) by acetylating a lysine cluster located in its hinge region between the DNA- and ligand-binding domains.	Lysine	201-207	nuclear receptor subfamily 3 group C member 1	Homo sapiens	155-178
34973011-2	2021	In previous work, we reported that the circadian transcription factor CLOCK and its heterodimer partner BMAL1 suppress the transcriptional activity of the glucocorticoid receptor (GR) by acetylating a lysine cluster located in its hinge region between the DNA- and ligand-binding domains.	Lysine	201-207	nuclear receptor subfamily 3 group C member 1	Homo sapiens	180-182
34825659-5	2021	The results of the present analysis provided the novel insight of rs201135441C>T (A490T) mutation, that A>T change i.e. nonpolar amino acid to polar amino acid stabilizes the enzyme-substrate (EZH2-Histone) complex which in turn promotes trimethylation over histone 3 (H3) at lysine residue 27 (H3K27me3) and this might be leading to the methylation of the promoter region of various cancer preventive genes, hence may increase the risk of breast cancer susceptibility.	Lysine	276-282	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	193-197
34825659-5	2021	The results of the present analysis provided the novel insight of rs201135441C>T (A490T) mutation, that A>T change i.e. nonpolar amino acid to polar amino acid stabilizes the enzyme-substrate (EZH2-Histone) complex which in turn promotes trimethylation over histone 3 (H3) at lysine residue 27 (H3K27me3) and this might be leading to the methylation of the promoter region of various cancer preventive genes, hence may increase the risk of breast cancer susceptibility.	Lysine	276-282	H3 clustered histone 14	Homo sapiens	258-271
35512565-1	2022	Acetylation of histone lysine residues by histone acetyltransferase (HAT) p300 and its paralog CBP play important roles in gene regulation in health and diseases.	Lysine	23-29	CREB binding protein	Homo sapiens	95-98
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	ring finger protein 111	Homo sapiens	99-105
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	ring finger protein 111	Homo sapiens	142-148
35483499-8	2022	Of these, downregulation of the tumor metastatic microenvironment facilitator LOXL2, a copper-dependent enzyme catalyzing posttranslational oxidative deamination of peptidyl lysine, was of special interest.	Lysine	174-180	lysyl oxidase like 2	Homo sapiens	78-83
35490898-2	2022	Gag-PM interactions are mediated by the matrix (MA) domain, which contains a myristoyl group (myr) and a basic patch formed by lysine and arginine residues.	Lysine	127-133	Pr55	Human T-cell leukemia virus type I	0-3
35447235-5	2022	Acetylation levels of histone H3 at lysine 9 and H4 were also higher in the homeologous SULT1 genes on the S-subgenome than those on the L-subgenome, however, methylation levels of histone H3 at lysine 9 and DNA methylation levels showed no correlation with their transcript levels.	Lysine	36-42	histone H3	Xenopus laevis	22-32
35447235-5	2022	Acetylation levels of histone H3 at lysine 9 and H4 were also higher in the homeologous SULT1 genes on the S-subgenome than those on the L-subgenome, however, methylation levels of histone H3 at lysine 9 and DNA methylation levels showed no correlation with their transcript levels.	Lysine	195-201	histone H3	Xenopus laevis	22-32
35569794-4	2022	Here, we report that four lysine-linked poly-Ub chains (LLPUCs) were involved in F508del-CFTR biogenesis: LLPUCs linked by K11 or K48 facilitated F508del-CFTR degradation, whereas the other two linked by K63 and K33 protected F508del-CFTR from degradation.	Lysine	26-32	CF transmembrane conductance regulator	Homo sapiens	89-93
35136209-8	2022	Mechanistically, KDM6A promotes the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently leads to the inactivation of p65.	Lysine	89-95	lysine demethylase 6A	Homo sapiens	17-22
35569794-4	2022	Here, we report that four lysine-linked poly-Ub chains (LLPUCs) were involved in F508del-CFTR biogenesis: LLPUCs linked by K11 or K48 facilitated F508del-CFTR degradation, whereas the other two linked by K63 and K33 protected F508del-CFTR from degradation.	Lysine	26-32	CF transmembrane conductance regulator	Homo sapiens	154-158
35569794-4	2022	Here, we report that four lysine-linked poly-Ub chains (LLPUCs) were involved in F508del-CFTR biogenesis: LLPUCs linked by K11 or K48 facilitated F508del-CFTR degradation, whereas the other two linked by K63 and K33 protected F508del-CFTR from degradation.	Lysine	26-32	CF transmembrane conductance regulator	Homo sapiens	234-238
35569794-6	2022	F508del-CFTR utilizes four specific lysine-linked poly-Ub chains during its biogenesis for opposite destiny through different identification by proteasomal shuttle protein or receptors.	Lysine	36-42	CF transmembrane conductance regulator	Homo sapiens	8-12
35610640-1	2022	BACKGROUND: Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage.	Lysine	66-72	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	12-39
35574589-2	2022	EZH2 - an important histone methyltransferase that writes histone H3 lysine 27 trimethylation marks - is known to be dysregulated in cancer cells.	Lysine	69-75	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
35531606-1	2022	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the expression of downstream target genes by catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	160-166	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
35531606-1	2022	Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the expression of downstream target genes by catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	160-166	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
35610640-1	2022	BACKGROUND: Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage.	Lysine	66-72	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	41-45
35614093-0	2022	An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility.	Lysine	16-22	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	3-8
35614130-5	2022	Mechanistically, HDAC6 directly deacetylated CBP-catalyzed acetylation of signal transducer and activator of transcription 4 (STAT4)-lysine (K) 667 via its enzymatic activity.	Lysine	133-139	histone deacetylase 6	Mus musculus	17-22
35614066-4	2022	On the base of DYRK2 acting as a promising target, we further discover a highly selective DYRK2 inhibitor YK-2-69, which specifically interacts with Lys-231 and Lys-234 in the co-crystal structure.	Lysine	149-152	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	15-20
35614066-4	2022	On the base of DYRK2 acting as a promising target, we further discover a highly selective DYRK2 inhibitor YK-2-69, which specifically interacts with Lys-231 and Lys-234 in the co-crystal structure.	Lysine	149-152	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	90-95
35614066-4	2022	On the base of DYRK2 acting as a promising target, we further discover a highly selective DYRK2 inhibitor YK-2-69, which specifically interacts with Lys-231 and Lys-234 in the co-crystal structure.	Lysine	161-164	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	90-95
35631316-0	2022	Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model.	Lysine	39-45	mechanistic target of rapamycin kinase	Homo sapiens	69-73
35631316-2	2022	Previous in vitro and in vivo results show that three specific amino acids, histidine, lysine, and threonine, synergistically inhibit mTOR activity and behavior.	Lysine	87-93	mechanistic target of rapamycin kinase	Homo sapiens	134-138
35631316-8	2022	Exposure to threonine, histidine, and lysine led to decreased mTOR activity and markedly reduced organoid size, supporting findings in rodent studies.	Lysine	38-44	mechanistic target of rapamycin kinase	Homo sapiens	62-66
35631316-11	2022	Threonine, histidine, and lysine exposure impacts the early development of human cerebral organoids, illustrated by the inhibition of mTOR activity, reduced size, and altered gene expression.	Lysine	26-32	mechanistic target of rapamycin kinase	Homo sapiens	134-138
35436101-2	2022	TDG contains a long, unstructured N-terminus that contains four known sites of acetylation: lysine (K) residues 59, 83, 84, and 87.	Lysine	92-98	thymine DNA glycosylase	Homo sapiens	0-3
35595742-2	2022	This study aims to develop nutrient-rich maize genotypes by incorporating crtRB1 and o2 genes associated with increased beta-carotene, lysine, and tryptophan levels.	Lysine	135-141	beta-carotene hydroxylase	Zea mays	74-80
35439434-3	2022	Here, we implicate methylation of histone H3 at lysine 4 by SETD1A-BOD1L in the recruitment of RIF1 to DSBs.	Lysine	48-54	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	60-66
35439434-3	2022	Here, we implicate methylation of histone H3 at lysine 4 by SETD1A-BOD1L in the recruitment of RIF1 to DSBs.	Lysine	48-54	biorientation of chromosomes in cell division 1 like 1	Homo sapiens	67-72
35581255-2	2022	By adopting the permethylated beta-cyclodextrin (perm beta-CD)-protonated L-Lysine non-covalent complex as a prototypical system, we present the infrared multiple photon dissociation (IRMPD) spectrum of the gas phase complex produced by electrospray ionization technique.	Lysine	74-82	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	54-61
35581255-3	2022	In order to elucidate the structure of perm beta-CD)/LysH+ complex in the gas phase, we carry out quantum chemical calculations to assign the two strong peaks at 3,340 and 3,560 cm-1 in the IRMPD spectrum, finding that the carboxyl forms loose hydrogen bonding with the perm beta-CD, whereas the ammonium group of L-Lysine is away from the perm beta-CD unit.	Lysine	314-322	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
35581255-4	2022	By simulating the structures of perm beta-CD/H+/L-Lysine complex in solution using the supramolecule/continuum model, we find that the extremely unstable gas phase structure corresponds to the most stable conformer in solution.	Lysine	50-56	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	37-44
35532818-1	2022	NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases.	Lysine	98-104	nuclear receptor binding SET domain protein 2	Homo sapiens	6-10
35538229-0	2022	Comprehensive profiling and kinetic studies of glycated lysine residues in human serum albumin.	Lysine	56-62	albumin	Homo sapiens	81-94
35538229-10	2022	Through glycation of albumin at different glucose concentrations, we determine the rate constants of glycation for every lysine residue by simultaneous comparative analysis.	Lysine	121-127	albumin	Homo sapiens	21-28
35536540-6	2022	Our results demonstrate that this in vitro CpB treatment protocol can be used as a platform strategy to improve main peak for mAbs that exhibit high levels of basic variants attributable to C-terminal lysines.	Lysine	201-208	carboxypeptidase B	Cricetulus griseus	43-46
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	14-17	solute carrier family 15 member 1	Homo sapiens	92-99
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	18-21	solute carrier family 15 member 1	Homo sapiens	92-99
35526384-9	2022	In CBZ-treated groups, 29 and 30 peptides showed significantly increased respectively in HLA-A*24:02 and HLA-B*15:02 positive cells comprising Lysine in POmega, but the sources of these lysine peptides are different.	Lysine	143-149	major histocompatibility complex, class I, A	Homo sapiens	89-94
35100351-8	2022	The lysine analog e-aminocaproic acid blocks plasmin-catalyzed bradykinin generation.	Lysine	4-10	kininogen 1	Homo sapiens	63-73
35507647-5	2022	Mechanistically, we supported that extracellular AKG binds with a purinergic receptor, P2RX4, to initiate the solute carrier family 25 member 11 (SLC25A11)-dependent nucleus translocation of intracellular AKG and subsequently induces demethylation of lysine 27 on histone 3 (H3K27) in the seprina1e promoter region to decrease hepatic gluconeogenesis.	Lysine	251-257	purinergic receptor P2X, ligand-gated ion channel 4	Mus musculus	87-92
35625593-3	2022	Using a number of mutant variants of cytochrome c, we showed that both substitutions of Lys residues from the universal binding site for oppositely charged Glu residues and mutations leading to a decrease in the conformational mobility of the red Omega-loop in almost all cases did not affect the ability of cytochrome c to bind to cardiolipin.	Lysine	88-91	cytochrome c, somatic	Homo sapiens	37-49
35625593-3	2022	Using a number of mutant variants of cytochrome c, we showed that both substitutions of Lys residues from the universal binding site for oppositely charged Glu residues and mutations leading to a decrease in the conformational mobility of the red Omega-loop in almost all cases did not affect the ability of cytochrome c to bind to cardiolipin.	Lysine	88-91	cytochrome c, somatic	Homo sapiens	308-320
35609316-5	2022	EZH2 catalyzed trimethylation of lysine 27 on histone 3 (H3K27me3) in GADD45A promoter to suppress its transcription.	Lysine	33-39	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
35351830-5	2022	We here dissect a higher primates-restricted interaction between RbFOX1 and the transcriptional corepressor Lysine Specific Demethylase 1 (LSD1/KDM1A).	Lysine	108-114	RNA binding fox-1 homolog 1	Homo sapiens	65-71
35351830-14	2022	Here we move a step forward, characterizing a disease-relevant higher primates-specific pathway by which RbFOX1 acquires the ability to regulate neuronal levels of Lysine Specific Demethylase 1, an epigenetic modulator of environmental stress response.	Lysine	164-170	RNA binding fox-1 homolog 1	Homo sapiens	105-111
34988909-8	2022	Ubiquitination of histone H2B at lysine residue 120 (H2BK120ub) at relapse was significantly decreased at the protein level, indicating that PHF6 loss might downregulate a TNF-alpha signaling pathway by reduction of H2BK120ub.	Lysine	33-39	tumor necrosis factor	Homo sapiens	172-181
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	WD repeat domain 5	Homo sapiens	19-37
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	WD repeat domain 5	Homo sapiens	39-43
35378129-8	2022	Taken together, our results suggest a model in which SETMAR impacts differential expression and alternative splicing of genes associated with transcription and neuronal function, potentially through both its TIR-specific DNA-binding and lysine methyltransferase activities, consistent with a role for SETMAR in simian primate development.	Lysine	237-243	SET domain and mariner transposase fusion gene	Homo sapiens	53-59
35014621-3	2022	Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation.	Lysine	219-225	menin 1	Homo sapiens	0-5
35569264-1	2022	EZH2, the catalytic subunit of PRC2, catalyzes histone H3 lysine 27 (H3K27) trimethylation to induce the agglutination of chromosomes and in turn represses the transcription of the target genes.	Lysine	58-64	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
35014621-3	2022	Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation.	Lysine	219-225	menin 1	Homo sapiens	27-62
35014621-3	2022	Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation.	Lysine	219-225	menin 1	Homo sapiens	64-68
35014621-3	2022	Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation.	Lysine	219-225	androgen receptor	Homo sapiens	103-105
35014621-3	2022	Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation.	Lysine	219-225	androgen receptor	Homo sapiens	184-186
35503036-8	2022	Mechanically, the depletion of circMRPS35 reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) on forkhead box O3 (FOXO3) promoter in osteosarcoma cells.	Lysine	79-85	forkhead box O3	Homo sapiens	114-129
35503036-8	2022	Mechanically, the depletion of circMRPS35 reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) on forkhead box O3 (FOXO3) promoter in osteosarcoma cells.	Lysine	79-85	forkhead box O3	Homo sapiens	131-136
35574370-2	2022	Here, we found that lncRNA PRADX was overexpressed in the mesenchymal GBM and was transcriptionally regulated by RUNX1-CBFbeta complex, overexpressed PRADX suppressed BLCAP expression via interacting with EZH2 and catalyzing trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	243-249	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	205-209
35571917-15	2022	Moreover, NA significantly increased the levels phosphorylation of histone H3 at Ser10 (pH3S10) in ileum and the levels of acetylation of lysine 9 on histone 3 (acH3K9) and acH3K27 in colon (P < 0.05) in weaned piglets infected with ETEC K88 (P < 0.05).	Lysine	138-144	ETEC	Sus scrofa	233-237
35481706-9	2022	Mucosal myeloperoxidase activity was lower in the lysyl-lysine group (P<0.05), suggesting less inflammation.	Lysine	56-62	myeloperoxidase	Homo sapiens	8-23
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Lysine	16-22	lin-28 homolog A	Homo sapiens	38-44
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Lysine	16-22	lin-28 homolog A	Homo sapiens	105-111
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Lysine	16-22	tripartite motif containing 28	Homo sapiens	138-142
35478054-7	2022	In this study, we demonstrated that while individually BIX01294, an inhibitor of histone methyltransferase G9a, DZNep, an inhibitor of lysine methyltransferase EZH2, and Trichostatin A (TSA), an inhibitor of histone deacetylase at their low concentrations showed a moderate effect on the viability of U87 glioblastoma cells, in combinations they exhibited a synergistic effect.	Lysine	135-141	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	160-164
35481706-10	2022	The inclusion of glycyl-sarcosine with lysyl-lysine abolished the dipeptide effects on whole body and tissue-specific protein synthesis (P<0.05), suggesting that improved lysine availability was mediated by PepT1.	Lysine	171-177	solute carrier family 15 member 1	Homo sapiens	207-212
35629898-7	2022	Regarding therapeutics, TNF inhibitors may increase the levels of tryptophan, valine, lysine, creatinine and alanine, whereas JAK/STAT inhibitors may modulate exclusively fatty acids.	Lysine	86-92	tumor necrosis factor	Homo sapiens	24-27
35460275-2	2022	Down regulation of MIR156A/MIR156C, the two major sources of miR156, is accompanied by a decrease in acetylation of histone 3 lysine 27 (H3K27ac) and an increase in trimethylation of H3K27 (H3K27me3) at MIR156A/MIR156C in Arabidopsis.	Lysine	126-132	MIR156a	Arabidopsis thaliana	19-26
35467350-6	2022	The docking calculations and molecular dynamics simulations showed how 1 enters the PSMA funnel region and how pharmacophore Glu-urea-Lys interacts with the arginine patch, the S1", and S1 subpockets by forming hydrogen and van der Waals bonds.	Lysine	134-137	folate hydrolase 1	Homo sapiens	84-88
35566085-6	2022	The PSMA ligand was developed based on the glutamine-urea-lysine (Glu-urea-Lys) structure.	Lysine	75-78	folate hydrolase 1	Homo sapiens	4-8
35474067-5	2022	We now report that Cullin 3-KLHL20, a trans-Golgi network (TGN)-localized E3 ubiquitin ligase, polyubiquitinates SERINC5 at lysine 130 via K33/K48-linked ubiquitination.	Lysine	124-130	kelch like family member 20	Homo sapiens	28-34
35446253-4	2022	Our structural and mutagenesis analyses show that seven transmembrane helices form a deep pocket for ligand binding and that SSTR2 recognizes the highly conserved Trp-Lys motif of SST-14 at the bottom of the pocket.	Lysine	167-170	somatostatin receptor 2	Homo sapiens	125-130
35445296-0	2022	Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.	Lysine	26-32	SET domain, bifurcated 1	Mus musculus	60-66
35445296-0	2022	Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.	Lysine	26-32	SET domain containing 2	Mus musculus	68-73
35445296-0	2022	Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.	Lysine	26-32	cerebellar folial pattern 1	Mus musculus	79-83
35452683-0	2022	EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1alpha is repressed by SET7-catalyzed lysine methylation.	Lysine	108-114	egl-9 family hypoxia inducible factor 1	Homo sapiens	0-5
35452683-0	2022	EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1alpha is repressed by SET7-catalyzed lysine methylation.	Lysine	108-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-76
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	27-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	65-70
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	27-33	egl-9 family hypoxia inducible factor 1	Homo sapiens	129-134
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	27-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	182-191
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	86-92	egl-9 family hypoxia inducible factor 1	Homo sapiens	65-70
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	86-92	egl-9 family hypoxia inducible factor 1	Homo sapiens	129-134
35420470-8	2022	X-ray crystallographic studies, molecular docking, and molecular dynamics simulations of the OXA-23-MA-1-206 complex show that the C6 hydroxymethyl group forms a hydrogen bond with the carboxylated catalytic lysine of OXA-23, effectively preventing deacylation.	Lysine	208-214	class D beta-lactamase OXA-23	Acinetobacter baumannii	93-99
35420470-8	2022	X-ray crystallographic studies, molecular docking, and molecular dynamics simulations of the OXA-23-MA-1-206 complex show that the C6 hydroxymethyl group forms a hydrogen bond with the carboxylated catalytic lysine of OXA-23, effectively preventing deacylation.	Lysine	208-214	class D beta-lactamase OXA-23	Acinetobacter baumannii	218-224
35394699-7	2022	WHSC1 further increased the expression of DNA topoisomerase II alpha (TOP2A) in HCC by inducing the dimethylation of histone H3 lysine 36 (H3K36me2) in the TOP2A promoter region.	Lysine	128-134	nuclear receptor binding SET domain protein 2	Homo sapiens	0-5
35418650-5	2022	Loss of Chd7 reduces the restriction of PPAR-gamma and then PPAR-gamma associates with trimethylated histone H3 at lysine 4 (H3K4me3), which subsequently activates the transcription of downstream adipogenic genes and disrupts the balance between osteogenic and adipogenic differentiation.	Lysine	115-121	peroxisome proliferator activated receptor gamma	Homo sapiens	60-70
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	258-285
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	287-291
35455942-4	2022	Here, we show for the first time that deficiency or pharmacological inhibition of the cellular lysine-methyltransferase SMYD2 decreases TMPRSS2 expression on both mRNA and protein levels.	Lysine	95-101	transmembrane serine protease 2	Homo sapiens	136-143
35493099-10	2022	In addition, PPI network analysis showed KDM5 family proteins have strong interactions with histone deacetylase family 1 (HDAC1), which could modify the lysines of histone H3, and co-act on many pathways, including the "longevity-regulating pathway" and "Notch signaling pathway".	Lysine	153-160	histone deacetylase 1	Homo sapiens	92-120
35493099-10	2022	In addition, PPI network analysis showed KDM5 family proteins have strong interactions with histone deacetylase family 1 (HDAC1), which could modify the lysines of histone H3, and co-act on many pathways, including the "longevity-regulating pathway" and "Notch signaling pathway".	Lysine	153-160	histone deacetylase 1	Homo sapiens	122-127
35457022-6	2022	HFD inhibited the subcellular localization of SIRT3 into the mitochondrion, resulting in the up-regulating of mtHSP70 acetylation via lysine residues 493 and 507.	Lysine	134-140	sirtuin 3	Homo sapiens	46-51
35457022-6	2022	HFD inhibited the subcellular localization of SIRT3 into the mitochondrion, resulting in the up-regulating of mtHSP70 acetylation via lysine residues 493 and 507.	Lysine	134-140	heat shock protein family A (Hsp70) member 9	Homo sapiens	110-117
35453416-1	2022	Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-kappaB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein for the Toll-like receptor (TLR) and interleukin (IL)-1beta receptor.	Lysine	206-212	histone deacetylase 6	Rattus norvegicus	0-21
35453416-1	2022	Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-kappaB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein for the Toll-like receptor (TLR) and interleukin (IL)-1beta receptor.	Lysine	206-212	histone deacetylase 6	Rattus norvegicus	23-28
35388001-4	2022	Here we show that depletion of STAG2 in melanoma cells leads to expansion of topologically associating domains (TADs) and enhances the formation of acetylated histone H3 lysine 27 (H3K27ac)-associated DNA loops at sites where binding of STAG2 is switched to its paralog STAG1.	Lysine	170-176	stromal antigen 1	Homo sapiens	270-275
35432536-12	2022	Meanwhile, ChIP assay showed that the knockdown of KAT6B inhibited the enrichment of histone H3 lysine 23 acetylation (H3K23ac) and RNA polymerase II (RNA pol II) on STAT3 promoter in the cells.	Lysine	96-102	signal transducer and activator of transcription 3	Homo sapiens	166-171
35385430-1	2022	OBJECTIVE: Causative variants in SETD1B, encoding a lysine-specific methyltransferase, have recently been associated with a neurodevelopmental phenotype encompassing intellectual disability, autistic features, pronounced language delay, and epilepsy.	Lysine	52-58	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	33-39
35151207-1	2022	The histone methyltransferase SET domain bifurcated 1 (SETDB1) catalyzes the trimethylation of lysine 9 of histone H3, thereby regulating gene expression.	Lysine	95-101	SET domain, bifurcated 1	Mus musculus	55-61
35063407-2	2022	The SET-domain containing 5 (SETD5) is a previously uncharacterized member of the histone lysine methyltransferase family.	Lysine	90-96	SET domain containing 5	Homo sapiens	4-27
35063407-2	2022	The SET-domain containing 5 (SETD5) is a previously uncharacterized member of the histone lysine methyltransferase family.	Lysine	90-96	SET domain containing 5	Homo sapiens	29-34
35304099-0	2022	The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta.	Lysine	34-40	apolipoprotein A1	Homo sapiens	15-33
35143753-7	2022	Finally, LSD1 knockdown inhibited VSMC proliferation by increasing p21 expression, which is associated with LSD1 mediated di-methylated histone H3 on lysine 4 (H3K4me2) modification.	Lysine	150-156	lysine (K)-specific demethylase 1A	Mus musculus	9-13
35143753-7	2022	Finally, LSD1 knockdown inhibited VSMC proliferation by increasing p21 expression, which is associated with LSD1 mediated di-methylated histone H3 on lysine 4 (H3K4me2) modification.	Lysine	150-156	lysine (K)-specific demethylase 1A	Mus musculus	108-112
35304099-8	2022	Our results suggest that lysine residues within proximity of the known MPO binding sites on HDL are preferentially targeted by the enzymatic (MPO) carbamylation pathway, whereas the non-enzymatic pathway leads to nearly uniform distribution of carbamylated lysine residues along the apoA-I polypeptide chain.	Lysine	25-31	myeloperoxidase	Homo sapiens	71-74
35022315-1	2022	KDM6A, an X chromosome-linked histone lysine demethylase, was reported to be frequently mutated in many tumor types including breast and bladder cancer.	Lysine	38-44	lysine demethylase 6A	Homo sapiens	0-5
35304099-8	2022	Our results suggest that lysine residues within proximity of the known MPO binding sites on HDL are preferentially targeted by the enzymatic (MPO) carbamylation pathway, whereas the non-enzymatic pathway leads to nearly uniform distribution of carbamylated lysine residues along the apoA-I polypeptide chain.	Lysine	25-31	myeloperoxidase	Homo sapiens	142-145
35304099-8	2022	Our results suggest that lysine residues within proximity of the known MPO binding sites on HDL are preferentially targeted by the enzymatic (MPO) carbamylation pathway, whereas the non-enzymatic pathway leads to nearly uniform distribution of carbamylated lysine residues along the apoA-I polypeptide chain.	Lysine	25-31	apolipoprotein A1	Homo sapiens	283-289
35304099-8	2022	Our results suggest that lysine residues within proximity of the known MPO binding sites on HDL are preferentially targeted by the enzymatic (MPO) carbamylation pathway, whereas the non-enzymatic pathway leads to nearly uniform distribution of carbamylated lysine residues along the apoA-I polypeptide chain.	Lysine	257-263	myeloperoxidase	Homo sapiens	142-145
35426591-5	2022	We have performed a large crystallographic high-throughput fragment screen against the therapeutically relevant second bromodomain of the Pleckstrin-homology domain interacting protein (PHIP2) that revealed 52 different fragments bound across 4 distinct sites, 47 of which were bound to the pharmacologically relevant acetylated lysine (Kac) binding site.	Lysine	329-335	pleckstrin homology domain interacting protein	Homo sapiens	138-184
35452382-14	2022	Similarly, microbes involving biosynthesis of l-lysine, l-threonine, and l-methionine were significantly associated with lower estradiol, SHBG, and higher levels of total testosterone.Conclusion.	Lysine	46-54	sex hormone binding globulin	Homo sapiens	138-142
35349697-6	2022	Here, we elucidate that SIRT4 deacetylates the conserved lysine residue at 50 (K50) in MTHFD2.	Lysine	57-63	sirtuin 4	Homo sapiens	24-29
35353318-10	2022	Finally, phenylalanine was identified as a disaggregation agent for insulin, and lysine, tyrosine, phenylalanine, and tryptophan were identified as disaggregation agents for IFN-beta from the molecular dynamics study.	Lysine	81-87	IFN1@	Homo sapiens	174-182
35432328-5	2022	In order to avoid the use of these markers, not appropriate for human vaccines, we used CRISPR/Cas9 to generate unmarked mutations in the lysA gene, thus obtaining a lysine auxotrophic BCG strain.	Lysine	166-172	cyclic nucleotide binding domain containing 2	Mus musculus	88-94
35311258-4	2022	L3MBTL3 is a methyl-lysine reader protein that binds to the Cul4DCAF5 E3 ligase complex and targets methylated proteins for proteasomal degradation.	Lysine	20-26	L3MBTL histone methyl-lysine binding protein 3	Homo sapiens	0-7
35347798-5	2022	Epigenetic modification analysis revealed that Hcy significantly increased levels of DNA methylation and H3 lysine 9 dimethylation (H3K9me2) on ERO1alpha promoter, which attributed to up-regulated DNA methyltransferase 1 (DNMT1) and G9a respectively.	Lysine	108-114	DNA methyltransferase (cytosine-5) 1	Mus musculus	197-220
35351142-14	2022	Furthermore, histone H4-Lys-20 monomethylation (H4K20me1), which is downstream of SETD8, was accompanied by ELK1 localization at the same promoter region of bach1.	Lysine	24-27	N-lysine methyltransferase SETD8-like	Rattus norvegicus	82-87
35351142-14	2022	Furthermore, histone H4-Lys-20 monomethylation (H4K20me1), which is downstream of SETD8, was accompanied by ELK1 localization at the same promoter region of bach1.	Lysine	24-27	BTB domain and CNC homolog 1	Homo sapiens	157-162
35333774-9	2022	The suppression of KAT5 by siRNA repressed the enrichment of histone H3 acetylation at lysine 27 and RNA polymerase II on promoter of MAFB.	Lysine	87-93	MAF bZIP transcription factor B	Homo sapiens	134-138
35346195-13	2022	Mechanistically, we demonstrated that BMI1 directly binds to the promoter region of SIK1 in a complex with RING1B to promote monoubiquitination of histone H2A at lysine 119 (H2AK119ub) and inhibit H3K4 trimethylation (H3K4me3), resulting in inhibition of SIK1 transcription.	Lysine	162-168	Bmi1 polycomb ring finger oncogene	Mus musculus	38-42
35350980-15	2022	Mechanistic research indicated that MZF1, SETD8, and its downstream target histone H4 lysine 20 methylation (H4K20me1) all occupied the WNT5A promoter region.	Lysine	86-92	N-lysine methyltransferase SETD8-like	Rattus norvegicus	42-47
35350980-15	2022	Mechanistic research indicated that MZF1, SETD8, and its downstream target histone H4 lysine 20 methylation (H4K20me1) all occupied the WNT5A promoter region.	Lysine	86-92	Wnt family member 5A	Rattus norvegicus	136-141
35392432-12	2022	Analysis on molecular mechanisms revealed that KAT5 bonded to the promoter region of PD-L1 and upregulated its expression via enhancing histone H3 lysine 27 acetylation (H3K27ac), whereas ASP downregulated KAT5 expression and blocked this phenomenon.	Lysine	147-153	CD274 molecule	Sus scrofa	85-90
35454092-4	2022	Plg-RKT is a structurally unique plasminogen receptor because it is an integral membrane protein that is synthesized with and binds plasminogen via a C-terminal lysine exposed on the cell surface.	Lysine	161-167	plasminogen receptor with a C-terminal lysine	Homo sapiens	0-7
35322151-0	2022	The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors.	Lysine	12-18	scalloped	Drosophila melanogaster	72-76
35456546-4	2022	The Lys-PCLA bioconjugates are prepared using thiol-ene reaction between thiolated lysozyme (Lys-SH) and acrylated PCLA (PCLA-Ac).	Lysine	4-7	lysozyme	Homo sapiens	83-91
35331314-0	2022	Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias.	Lysine	25-31	DOT1 like histone lysine methyltransferase	Homo sapiens	53-58
35331314-1	2022	Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis.	Lysine	85-91	DOT1 like histone lysine methyltransferase	Homo sapiens	58-63
35258919-3	2022	Here, we developed a novel Lys-AuNPs@MoS2 nanocomposite self-assembled microfluidic immunoassay biochip with digital signal output and applied it to the simultaneous detection of multiple serum biomarkers including inflammatory factors and cardiovascular biomarkers, PCT, CRP, IL6, cTnI, cTnT, and NT-BNP, with high throughput and sensitivity.	Lysine	27-30	C-reactive protein	Homo sapiens	272-275
35258919-3	2022	Here, we developed a novel Lys-AuNPs@MoS2 nanocomposite self-assembled microfluidic immunoassay biochip with digital signal output and applied it to the simultaneous detection of multiple serum biomarkers including inflammatory factors and cardiovascular biomarkers, PCT, CRP, IL6, cTnI, cTnT, and NT-BNP, with high throughput and sensitivity.	Lysine	27-30	interleukin 6	Homo sapiens	277-280
35258919-3	2022	Here, we developed a novel Lys-AuNPs@MoS2 nanocomposite self-assembled microfluidic immunoassay biochip with digital signal output and applied it to the simultaneous detection of multiple serum biomarkers including inflammatory factors and cardiovascular biomarkers, PCT, CRP, IL6, cTnI, cTnT, and NT-BNP, with high throughput and sensitivity.	Lysine	27-30	troponin T2, cardiac type	Homo sapiens	288-292
35322151-11	2022	Altogether, our findings indicate that TEAD/Sd can be acylated either on a cysteine or on a lysine, and suggest that these two different forms may have similar properties in cells.	Lysine	92-98	scalloped	Drosophila melanogaster	39-43
35371061-0	2022	Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages.	Lysine	25-31	interleukin 6	Homo sapiens	113-116
35298257-3	2022	Our results indicate that genomic instability in the absence of ATXR5/ATXR6-catalyzed histone H3 lysine 27 monomethylation in plants depends on H3.1, TSK, and DNA polymerase theta (Pol theta).	Lysine	97-103	DNA polymerase theta	Homo sapiens	159-179
35320725-2	2022	Here, we show that human SPT16 is ubiquitylated at lysine-674 (K674) by the DCAF14-CRL4 ubiquitin ligase.	Lysine	51-57	pleckstrin homology domain interacting protein	Homo sapiens	76-82
35025136-4	2022	Similarly, since p53 can be ubiquitylated at different lysine residues, it remains unclear if the eventual effect depends on the position of the lysine modified.	Lysine	55-61	tumor protein p53	Homo sapiens	17-20
35256668-1	2022	EZH2 plays an essential role at the beta-selection checkpoint of T lymphopoiesis by regulating histone H3 lysine 27 trimethylation (H3K27me3) via its canonical mode of action.	Lysine	106-112	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
35264561-0	2022	Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.	Lysine	20-26	TAR DNA binding protein	Homo sapiens	99-105
35264561-7	2022	Thus, distinct lysine acetylations modulate nuclear import, RNA binding and phase separation of TDP-43, suggesting regulatory mechanisms for TDP-43 pathogenesis.	Lysine	15-21	TAR DNA binding protein	Homo sapiens	96-102
35101441-2	2022	In the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, a number of arginine and lysine side-chains have been shown to be important for Cl- permeation.	Lysine	104-110	CF transmembrane conductance regulator	Homo sapiens	7-58
35058288-9	2022	Peli1 inhibited the PKCtheta pathway by lysine 48-mediated ubiquitination degradation in CD8+ TILs.	Lysine	40-46	protein kinase C theta	Homo sapiens	20-28
35245111-5	2022	The Foxp2+ neurons exhibit the most prominent gene expression changes among the different neuron subtypes in PFC, which correlate with changes in histone H3 lysine 4 trimethylation.	Lysine	157-163	forkhead box P2	Mus musculus	4-9
35230082-5	2022	Using this unnatural amino acid mutagenesis approach, we find that threonylation of Lys162 of Aurora kinase A inhibits its kinase activity both in vitro and in vivo and that the inhibitory effect can be reversed by the deacetylase Sirtuin 3, which removes the threonylated group from the lysine.	Lysine	288-294	sirtuin 3	Homo sapiens	231-240
35172677-17	2022	EZH2 inhibited miR-29b-3p expression by combining with miR-29b-3p promoter and trimethylation of histone H3-lysine 27-trimethylated upregulation, and then elevated MMP2 transcription and triggered microglia M1-type polarization, thus exacerbating depression-like behaviors and neuroinflammation of depression.	Lysine	108-114	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	0-4
35182729-7	2022	Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance.	Lysine	138-144	methionine adenosyltransferase 2A	Homo sapiens	17-22
35101451-6	2022	We identified the lysine 271 residue in the kinase domain as a major site of DLK ubiquitination and SUMO3 conjugation, and was thus responsible for regulating FKBP8-mediated proteasomal degradation that was inhibited by the substitution of the lysine 271 to arginine.	Lysine	18-24	mitogen-activated protein kinase kinase kinase 12	Homo sapiens	77-80
35101441-2	2022	In the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, a number of arginine and lysine side-chains have been shown to be important for Cl- permeation.	Lysine	104-110	CF transmembrane conductance regulator	Homo sapiens	60-64
35119862-0	2022	Dynamics of the Histone Acetyltransferase Lysine-Rich Loop in the Catalytic Core of the CREB-Binding Protein.	Lysine	42-48	CREB binding protein	Homo sapiens	88-108
35301489-4	2022	Specifically, the SAGA complex acetylates its Ada3 subunit at three sites (lysines 8, 14 and 182) that are dynamically deacetylated by Rpd3.	Lysine	75-82	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	135-139
35232199-10	2022	The RPST simulation with a relatively small number of replicas shows that the two amyloid-beta(16-22) peptides form the intermolecular antiparallel beta-bridges due to the hydrophilic side-chain contact between Lys and Glu and hydrophobic side-chain contact between Leu, Val, and Phe, which stabilizes the dimer of the peptides.	Lysine	211-214	amyloid beta precursor protein	Homo sapiens	82-94
35350907-1	2022	OBJECTIVE: To explore functions of the histone H3 lysine 79 (K79) methyltransferase Dot1L in the development of pancreatic cancer and evaluate the possibility of targeting Dot1L to inhibit pancreatic cancer progression.	Lysine	50-56	DOT1 like histone lysine methyltransferase	Homo sapiens	84-89
35046573-3	2022	Several mAbs (LY-CoV555, LY-CoV016, REGN10933, REGN10987 and CT-P59) completely lost neutralizing activity against B.1.1.529 virus in both Vero-TMPRSS2 and Vero-hACE2-TMPRSS2 cells, whereas others were reduced (COV2-2196 and COV2-2130 combination, ~12-fold decrease) or minimally affected (S309).	Lysine	14-16	transmembrane serine protease 2	Homo sapiens	144-151
35046573-3	2022	Several mAbs (LY-CoV555, LY-CoV016, REGN10933, REGN10987 and CT-P59) completely lost neutralizing activity against B.1.1.529 virus in both Vero-TMPRSS2 and Vero-hACE2-TMPRSS2 cells, whereas others were reduced (COV2-2196 and COV2-2130 combination, ~12-fold decrease) or minimally affected (S309).	Lysine	14-16	transmembrane serine protease 2	Homo sapiens	167-174
35074526-5	2022	Mechanism study suggests that ECL covalently modifies a previously undisclosed lysine 46 (K46) in H2B, and recruits E3 ubiquitin ligase RNF20 to promote H2Bub1 at K120.	Lysine	79-85	ring finger protein 20	Homo sapiens	136-141
35119862-4	2022	Both CBP and p300 contain a domain of about 110 residues (called the bromodomain) that recognizes histone tails with one or more acetylated lysine side chains.	Lysine	140-146	CREB binding protein	Homo sapiens	5-8
35371306-5	2022	In addition, we found that DDX21 directly recruited WDR5 to enhance trimethylation of histone H3 on Lys 4 (H3K4me3) on the CDK1 promoter.	Lysine	100-103	WD repeat domain 5	Homo sapiens	52-56
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	tumor protein p53	Homo sapiens	4-7
35137160-0	2022	Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation.	Lysine	105-111	SET domain containing 1B, histone lysine methyltransferase	Homo sapiens	34-40
35324659-1	2022	The assessment of aflatoxin B1 (AFB1) exposure using isotope-dilution liquid chromatography-mass spectrometry (LCMS) of AFB1-lysine adducts in human serum albumin (HSA) has proven to be a highly productive strategy for the biomonitoring of AFB1 exposure.	Lysine	125-131	albumin	Homo sapiens	149-162
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	peptidylprolyl isomerase F	Homo sapiens	56-60
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	tumor protein p53	Homo sapiens	83-86
35434453-2	2022	Trimethylation of lysine 27 of histone H3 at the cis-regulatory element of Hhex was maintained and that of lysine 4 was reduced during receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis, which was associated with a reduction of Hhex expression.	Lysine	107-113	hematopoietically expressed homeobox	Mus musculus	263-267
34996645-6	2022	Comparative analysis showed lactate and fumarate utilization by C. jejuni and C. coli exclusively, whereas ESBL-E. coli rapidly consumed asparagine, glutamine/arginine, lysine, threonine, tryptophan, pyruvate, glycerol, cellobiose, and glucose.	Lysine	169-175	EsbL	Escherichia coli	107-111
35169119-1	2022	The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation of histone H3 on lysine 27 residue (H3K27me3).	Lysine	186-192	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	72-76
35172132-1	2022	DOT1L methylates histone H3 lysine 79 during transcriptional elongation and is stimulated by ubiquitylation of histone H2B lysine 120 (H2BK120ub) in a classical trans-histone crosstalk pathway.	Lysine	28-34	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
35172132-1	2022	DOT1L methylates histone H3 lysine 79 during transcriptional elongation and is stimulated by ubiquitylation of histone H2B lysine 120 (H2BK120ub) in a classical trans-histone crosstalk pathway.	Lysine	123-129	DOT1 like histone lysine methyltransferase	Homo sapiens	0-5
35119848-3	2022	Without the ms2-modification, tRNAUUULys3 is incapable of correctly translating the insulin mRNA AAG codon for lysine at the site of protease cleavage between the A-chain and the C-peptide.	Lysine	111-117	insulin	Homo sapiens	84-91
35149557-5	2022	In brown and white adipocytes, lysine myristoylation of gravin-alpha is required for signaling via beta2- and beta3-adrenergic receptors (beta-ARs), which are G protein-coupled receptors (GPCRs).	Lysine	31-37	G protein-coupled receptor 162	Homo sapiens	99-104
34995500-1	2022	Inhibiting the histone 3 lysine 79 (H3K79) methyltransferase, disruptor of telomeric silencing 1-like (DOT1L), increases the efficiency of reprogramming somatic cells to induced pluripotent stem cells (iPSCs).	Lysine	25-31	DOT1 like histone lysine methyltransferase	Homo sapiens	103-108
35104142-2	2022	Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin and two thiol reactive groups used for re-bridging of a disulfide bond within the Fc molecule.	Lysine	117-123	insulin	Homo sapiens	0-7
35104142-2	2022	Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin and two thiol reactive groups used for re-bridging of a disulfide bond within the Fc molecule.	Lysine	117-123	insulin	Homo sapiens	135-142
35186104-11	2022	Enrichment analysis showed that quercetin, xanthine, lysine, kaempferol, ss-sitosterol, and four other active compounds were the main components of Danlong Dingchuan Decoction; IL-6, TNF, CXCL8, VEGFA, MAPK3, IL-10, PTGS2, IL-1beta, IL-4, and TLR4 were the potential targets for therapy.	Lysine	53-59	interleukin 6	Mus musculus	177-181
34982556-4	2022	The X-ray crystal structural analysis of ZL0590 in complex with human BRD4 BD1 and the associated mutagenesis study illustrate a first-in-class nonacetylated lysine (KAc) binding site located at the helix alphaB and alphaC interface that contains important BRD4 residues (e.g., Glu151) not commonly shared among other family members and is spatially distinct from the classic KAc recognition pocket.	Lysine	158-164	bromodomain containing 4	Homo sapiens	70-74
34982556-4	2022	The X-ray crystal structural analysis of ZL0590 in complex with human BRD4 BD1 and the associated mutagenesis study illustrate a first-in-class nonacetylated lysine (KAc) binding site located at the helix alphaB and alphaC interface that contains important BRD4 residues (e.g., Glu151) not commonly shared among other family members and is spatially distinct from the classic KAc recognition pocket.	Lysine	158-164	bromodomain containing 4	Homo sapiens	257-261
35158718-4	2022	A candidate-gene approach previously identified a nonsense mutation in the gene coding for the enzyme lysine-deficient 4 protein kinase (WNK4) associated with the disease in Burmese and Tonkinese cats.	Lysine	102-108	WNK lysine deficient protein kinase 4	Felis catus	137-141
35205350-8	2022	The Drosophila RpL22 has additional Ala-, Lys- and Pro-rich sequences at the amino terminus, which resembles the carboxy-terminal portion of histone H1 and histone H5.	Lysine	42-45	Ribosomal protein L22	Drosophila melanogaster	15-20
35172032-0	2022	Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis.	Lysine	94-100	thymoma viral proto-oncogene 1	Mus musculus	156-159
35115608-3	2022	Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center on blocking the WIN site of WDR5, an arginine binding cavity that engages MLL/SET enzymes that deposit histone H3 lysine 4 methylation (H3K4me).	Lysine	207-213	WD repeat domain 5	Homo sapiens	28-32
35115608-3	2022	Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center on blocking the WIN site of WDR5, an arginine binding cavity that engages MLL/SET enzymes that deposit histone H3 lysine 4 methylation (H3K4me).	Lysine	207-213	WD repeat domain 5	Homo sapiens	121-125
35100024-8	2022	Mechanistical studies reveal that high salt increases acetylated histone 3 lysine 27 (H3K27ac) on SIRT3 promoter in hepatocytes, thus inhibiting the binding of NRF2, and results in the sustained inhibition of SIRT3 expression.	Lysine	75-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164
35217833-7	2022	Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1-TAK1-TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-kappaB) signaling pathway.	Lysine	114-117	tripartite motif-containing 45	Mus musculus	38-44
35101125-3	2022	Suppressor of variegation 3-9 homolog 1 (SUV39H1) plays a vital role in mediating gene silencing via histone H3 trimethylation of lysine 9 (H3K9me3).	Lysine	130-136	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-39
35101125-3	2022	Suppressor of variegation 3-9 homolog 1 (SUV39H1) plays a vital role in mediating gene silencing via histone H3 trimethylation of lysine 9 (H3K9me3).	Lysine	130-136	SUV39H1 histone lysine methyltransferase	Homo sapiens	41-48
35217833-7	2022	Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1-TAK1-TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-kappaB) signaling pathway.	Lysine	114-117	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	286-308
35217833-7	2022	Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1-TAK1-TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-kappaB) signaling pathway.	Lysine	114-117	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	310-319
35106941-5	2022	We identified five potential ubiquitinated lysine residues in Arrdc4 using mass spectrometry.	Lysine	43-49	arrestin domain containing 4	Homo sapiens	62-68
35106941-6	2022	By analysing Arrdc4 lysine mutants we discovered that lysine 270 (K270) is critical for Arrdc4 function in EV biogenesis.	Lysine	20-26	arrestin domain containing 4	Homo sapiens	88-94
35159180-7	2022	In addition, the cell-adhesion ability, proliferative activity, and trimethylation of the histone H3 lysine 9 (H3K9me3) level were significantly altered in SETDB1-deficient porcine SSCs.	Lysine	101-107	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	156-162
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	OTU deubiquitinase 7B	Homo sapiens	17-23
35265200-10	2022	Additionally, HDAC5 diminished p65 acetylation at lysine-310, which is essential for the transcriptional activity of p65.	Lysine	50-56	histone deacetylase 5	Mus musculus	14-19
34545936-5	2022	The transcript level of SOC1 is elevated in brm-3, gnc, and brm-3/gnc mutants, which is associated with increased histone H3 lysine 4 tri-methylation (H3K4Me3) but decreased DNA methylation levels.	Lysine	125-131	AGAMOUS-like 20	Arabidopsis thaliana	24-28
34813504-1	2022	While current thinking posits that insulin signaling to GLUT4 exocytic translocation and glucose uptake in skeletal muscle and adipocytes is controlled by phosphorylation-based signaling, many proteins in this pathway are acetylated on lysine residues.	Lysine	236-242	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	56-61
35058574-6	2022	Co-targeting E2F and STAT3 synergistically reduced the levels of H2AZ, histone 3 lysine 27 acetylation (H3K27ac) and cell cycle gene transcription, indicating that E2F1 and STAT3 synergize to activate H2AZ gene transcription in GSCs.	Lysine	81-87	signal transducer and activator of transcription 3	Homo sapiens	21-26
35058574-6	2022	Co-targeting E2F and STAT3 synergistically reduced the levels of H2AZ, histone 3 lysine 27 acetylation (H3K27ac) and cell cycle gene transcription, indicating that E2F1 and STAT3 synergize to activate H2AZ gene transcription in GSCs.	Lysine	81-87	signal transducer and activator of transcription 3	Homo sapiens	173-178
35046516-4	2022	Mass spectrometric analysis identified PRMT5 lysine 387 as its succinylation site.	Lysine	45-51	protein arginine methyltransferase 5	Homo sapiens	39-44
35046516-7	2022	The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1, decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50, which promotes the formation of the PRMT5-Mep50 octamer.	Lysine	45-51	protein arginine methyltransferase 5	Homo sapiens	39-44
35055044-9	2022	Mice treated with L-lysine present decreased albumin endocytosis leading to proteinuria and albuminuria associated with inhibition of AKT activity.	Lysine	18-26	thymoma viral proto-oncogene 1	Mus musculus	134-137
35044827-0	2022	Class I histone deacetylases (HDAC1-3) are histone lysine delactylases.	Lysine	51-57	histone deacetylase 1	Homo sapiens	30-37
35051035-3	2022	This has been reported using ELISA, HPLC, or LC-MS/MS to measure the amount of AFB1-lysine released after proteolysis of serum albumin.	Lysine	84-90	albumin	Homo sapiens	127-134
35013237-5	2022	GRHL1 activity is regulated by post-translational lysine methylation and the phosphoinositide (PI) 3-kinase C2A.	Lysine	50-56	grainyhead like transcription factor 1	Homo sapiens	0-5
35013138-6	2022	Next, NRMT was identified to enrich histone-H3 lysine 4 trimethylation in the promoter of centromere protein A (CENPA) by chromatin immunoprecipitation assay.	Lysine	47-53	centromere protein A	Mus musculus	90-110
35013138-6	2022	Next, NRMT was identified to enrich histone-H3 lysine 4 trimethylation in the promoter of centromere protein A (CENPA) by chromatin immunoprecipitation assay.	Lysine	47-53	centromere protein A	Mus musculus	112-117
35224496-5	2022	Additionally, the simulations prospectively predicted several druggable cysteine and lysine sites, including the alphaH head cysteine in JNK1/3 and DFG + 6 cysteine in JNK2, corroborating the chemical proteomic screening data.	Lysine	85-91	mitogen-activated protein kinase 8	Homo sapiens	137-143
35051069-0	2022	Detection of Benzo(a)pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem Mass Spectrometry.	Lysine	66-72	albumin	Homo sapiens	82-89
35051069-2	2022	The exposure of humans to this PAH can be assessed by measuring stable blood protein adducts, such as to histidine and lysine in serum albumin, from their reactive metabolites.	Lysine	119-125	albumin	Homo sapiens	135-142
35070988-6	2021	Mechanistically, we found that INPP4B exerted its role via inhibiting the phosphorylation of Akt at lysine 473 but not threonine 308, which attenuated the activation of the PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway.	Lysine	100-106	AKT serine/threonine kinase 1	Homo sapiens	93-96
35046941-4	2021	Furthermore, lysine residue 224 of KLF4 was acetylated by p300/CBP-associated factor (PCAF), which was important for KLF4-mediated transactivation.	Lysine	13-19	Kruppel like factor 4	Rattus norvegicus	35-39
35046941-4	2021	Furthermore, lysine residue 224 of KLF4 was acetylated by p300/CBP-associated factor (PCAF), which was important for KLF4-mediated transactivation.	Lysine	13-19	Kruppel like factor 4	Rattus norvegicus	117-121
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	10-16	interleukin 6	Rattus norvegicus	161-165
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	46-52	interleukin 6	Rattus norvegicus	84-88
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	46-52	interleukin 6	Rattus norvegicus	161-165
35291604-2	2022	Methods: OVCAR3 cancer cells were treated with cisplatin, Ly 294002 (LY), and cisplatin+Ly to investigate the cytotoxicity effect of the mentioned groups via MTT assay.	Lysine	69-71	carbonic anhydrase 3	Homo sapiens	9-15
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Lysine	83-85	carbonic anhydrase 3	Homo sapiens	165-171
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Lysine	83-85	caspase 3	Homo sapiens	274-283
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Lysine	83-85	AKT serine/threonine kinase 1	Homo sapiens	288-291
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Lysine	83-85	AKT serine/threonine kinase 1	Homo sapiens	347-350
34983623-0	2022	Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-beta1/Smad3 pathway in diabetic nephropathy.	Lysine	8-14	transforming growth factor, beta 1	Rattus norvegicus	112-121
34983623-0	2022	Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-beta1/Smad3 pathway in diabetic nephropathy.	Lysine	8-14	SMAD family member 3	Rattus norvegicus	122-127
34958158-1	2022	Lysine-specific histone demethylase 1 (LSD1) as the first identified histone/lysine demethylase regulates gene expression and protein functions in diverse diseases.	Lysine	0-6	lysine (K)-specific demethylase 1A	Mus musculus	39-43
34958158-1	2022	Lysine-specific histone demethylase 1 (LSD1) as the first identified histone/lysine demethylase regulates gene expression and protein functions in diverse diseases.	Lysine	77-83	lysine (K)-specific demethylase 1A	Mus musculus	39-43
35224496-5	2022	Additionally, the simulations prospectively predicted several druggable cysteine and lysine sites, including the alphaH head cysteine in JNK1/3 and DFG + 6 cysteine in JNK2, corroborating the chemical proteomic screening data.	Lysine	85-91	mitogen-activated protein kinase 9	Homo sapiens	168-172
2517403-1	1989	The interaction between diamine oxidase (DAO) of human placenta and carboxyl-substituted lysines, including N-terminal lysine containing peptides, occurs at rather a high rate and is characterized by the following features.	Lysine	89-95	amine oxidase copper containing 1	Homo sapiens	24-39
2617455-5	1989	Plasminogen binding was inhibited by epsilon aminocaproic acid indicating that binding was mediated via lysine-binding regions of plasminogen.	Lysine	104-110	plasminogen	Homo sapiens	0-11
2617455-5	1989	Plasminogen binding was inhibited by epsilon aminocaproic acid indicating that binding was mediated via lysine-binding regions of plasminogen.	Lysine	104-110	plasminogen	Homo sapiens	130-141
2557894-2	1989	A different residue, which is most likely lysine, is the sixth heme ligand in oxidized spinach cytochrome f. The data for oxidized yeast cytochrome b are consistent with bis-histidine coordination of both hemes although the possibility that one of the hemes is ligated by histidine and lysine cannot be rigorously excluded.	Lysine	42-48	cytochrome b	Saccharomyces cerevisiae S288C	137-149
2517403-1	1989	The interaction between diamine oxidase (DAO) of human placenta and carboxyl-substituted lysines, including N-terminal lysine containing peptides, occurs at rather a high rate and is characterized by the following features.	Lysine	89-95	amine oxidase copper containing 1	Homo sapiens	41-44
2517403-4	1989	The inhibiting capacity of this compound is directly proportional to the peptide length; therefore, the tripeptides with the N-terminal lysine can be effective inhibitors that are not practically deaminated in the presence of DAO.	Lysine	136-142	amine oxidase copper containing 1	Homo sapiens	226-229
2508560-1	1989	The tertiary structure model of EF-Tu predicts that the amino acid sequence Val-Asp-His-Gly-Lys-Thr-Thr-Leu (residues 20-27) forms a pocket that binds the pyrophosphate group.	Lysine	92-95	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	32-37
2551068-5	1989	These results suggest that binding of lysine binding sites of plasmin or plasminogen with sct-PA enhanced its conversion to tct-PA by plasmin, and that there is a site on a t-PA molecule to bind to plasminogen or plasmin.	Lysine	38-44	plasminogen	Homo sapiens	62-69
2551068-5	1989	These results suggest that binding of lysine binding sites of plasmin or plasminogen with sct-PA enhanced its conversion to tct-PA by plasmin, and that there is a site on a t-PA molecule to bind to plasminogen or plasmin.	Lysine	38-44	plasminogen	Homo sapiens	73-80
2551068-5	1989	These results suggest that binding of lysine binding sites of plasmin or plasminogen with sct-PA enhanced its conversion to tct-PA by plasmin, and that there is a site on a t-PA molecule to bind to plasminogen or plasmin.	Lysine	38-44	plasminogen	Homo sapiens	73-80
2549026-3	1989	In the current study we demonstrate that this apparent Ca2+ channel function is specifically inhibited by the synthetic analogue of the fibrinogen gamma COOH-terminal peptide, His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (His-12-Val), but not by the adhesive protein sequence Arg-Gly-Asp-Ser (RGDS).	Lysine	200-203	ral guanine nucleotide dissociation stimulator	Homo sapiens	296-300
2505067-0	1989	Combined effect of dimethylnitrosamine and a lysine-restricted diet on O6-methylguanine-DNA methyltransferase levels in mouse tissues.	Lysine	45-51	O-6-methylguanine-DNA methyltransferase	Mus musculus	71-109
2514184-6	1989	Moreover, the results of lysine residue modification were suggestive of possible involvement of lysine in the antigenic determinants of DAO.	Lysine	25-31	D-amino acid oxidase	Sus scrofa	136-139
2514184-6	1989	Moreover, the results of lysine residue modification were suggestive of possible involvement of lysine in the antigenic determinants of DAO.	Lysine	96-102	D-amino acid oxidase	Sus scrofa	136-139
2551068-0	1989	Inhibition by tranexamic acid of the conversion of single-chain tissue plasminogen activator to its two chain form by plasmin: the presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin.	Lysine	195-201	plasminogen	Homo sapiens	71-78
2551068-0	1989	Inhibition by tranexamic acid of the conversion of single-chain tissue plasminogen activator to its two chain form by plasmin: the presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin.	Lysine	195-201	plasminogen	Homo sapiens	118-125
2676702-8	1989	Finally, catfish I GnRH is likely to have a lysine or arginine residue as it is the most hydrophilic family member.	Lysine	44-50	gonadotropin releasing hormone 1	Homo sapiens	19-23
2569479-0	1989	Role of catalytic and lysine-binding sites in plasmin-induced neutrophil adherence to endothelium.	Lysine	22-28	plasminogen	Homo sapiens	46-53
2506925-0	1989	Active-site modification of mammalian DNA polymerase beta with pyridoxal 5"-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket.	Lysine	133-139	DNA polymerase beta	Homo sapiens	38-57
2569479-8	1989	Elastase-derived plasminogen fragments corresponding to kringle 1+2+3 and kringle 4 (both of which contained the lysine-binding sites) possessed neutrophil adherence-promoting activities similar to plasmin, whereas miniplasminogen (which contains the catalytic site but no lysine-binding sites) had minimal effect, indicating the involvement of lysine-binding sites in the response.	Lysine	113-119	plasminogen	Homo sapiens	17-24
2472396-5	1989	In contrast to human alpha 2M, however, the binding and inhibition of proteinases was dependent on the ability of alpha 1I3 to form covalent cross-links to proteinase lysine residues.	Lysine	167-173	alpha-1-inhibitor III	Rattus norvegicus	114-123
2472396-5	1989	In contrast to human alpha 2M, however, the binding and inhibition of proteinases was dependent on the ability of alpha 1I3 to form covalent cross-links to proteinase lysine residues.	Lysine	167-173	endogenous retrovirus group K member 18	Homo sapiens	70-80
2569479-8	1989	Elastase-derived plasminogen fragments corresponding to kringle 1+2+3 and kringle 4 (both of which contained the lysine-binding sites) possessed neutrophil adherence-promoting activities similar to plasmin, whereas miniplasminogen (which contains the catalytic site but no lysine-binding sites) had minimal effect, indicating the involvement of lysine-binding sites in the response.	Lysine	273-279	plasminogen	Homo sapiens	17-24
2569479-8	1989	Elastase-derived plasminogen fragments corresponding to kringle 1+2+3 and kringle 4 (both of which contained the lysine-binding sites) possessed neutrophil adherence-promoting activities similar to plasmin, whereas miniplasminogen (which contains the catalytic site but no lysine-binding sites) had minimal effect, indicating the involvement of lysine-binding sites in the response.	Lysine	273-279	plasminogen	Homo sapiens	17-24
2569479-9	1989	Blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with tranexamic acid (IC50 of 5 mM) inhibited neutrophil adherence.	Lysine	9-15	plasminogen	Homo sapiens	33-40
2817813-15	1989	IFN alpha J and IFN-alpha 7 differ only by one amino acid, at position 107, where a lysine in IFN-alpha J has been replaced by a glutamic acid in the IFN-alpha 7.	Lysine	84-90	interferon alpha 7	Homo sapiens	16-27
2569479-10	1989	A monospecific polyclonal antibody against the lysine-binding sites also reduced the neutrophil adherence-promoting activity of plasmin.	Lysine	47-53	plasminogen	Homo sapiens	128-135
2554957-0	1989	Acid dissociation constant and apparent nucleophilicity of lysine-501 of the alpha-polypeptide of sodium and potassium ion activated adenosinetriphosphatase.	Lysine	59-65	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	133-156
2569479-11	1989	The results indicate that plasmin induces neutrophil adherence to the endothelium and that the effect is mediated by lysine-binding sites on plasmin.	Lysine	117-123	plasminogen	Homo sapiens	26-33
2569479-11	1989	The results indicate that plasmin induces neutrophil adherence to the endothelium and that the effect is mediated by lysine-binding sites on plasmin.	Lysine	117-123	plasminogen	Homo sapiens	141-148
2526127-5	1989	The augmented fibrin binding of rt-PA is partially abolished when the plasmin-degraded fibrin matrices are subsequently treated with carboxypeptidase B, demonstrating that this increased binding is dependent on the generation of carboxyl-terminal lysine residues in the fibrin matrix.	Lysine	247-253	plasminogen	Homo sapiens	70-77
2547466-3	1989	Chromatography of media from cells from normal mice treated with PTH on lysine-Sepharose resulted in the separation of latent collagenase and latent gelatinase.	Lysine	72-78	parathyroid hormone	Mus musculus	65-68
2547466-5	1989	Collagenase activity of media of cells from normal or mi/mi mice treated with PTH or LPS yielded identical elution patterns upon chromatography on lysine-Sepharose.	Lysine	147-153	parathyroid hormone	Mus musculus	78-81
2544737-8	1989	The exchange behavior of the human proteins is similar to that reported for a comparison of the exchange rates for myoglobins having lysine at position 45 with sperm whale myoglobin, which has arginine at this position.	Lysine	133-139	myoglobin	Physeter catodon	115-124
2778161-3	1989	Lactophorin and the seven components were rich in aspartic acid, threonine, serine, glutamic acid, leucine, and lysine.	Lysine	112-118	glycosylation dependent cell adhesion molecule 1	Bos taurus	0-11
2523891-2	1989	We found that after incubation of monolayer cultures with purified native human plasminogen in serum-containing medium, bound plasmin activity could be eluted from the cells with tranexamic acid, an analogue of lysine.	Lysine	211-217	plasminogen	Homo sapiens	80-87
2565905-7	1989	60% of the transported chimera was cleaved at the Arg-Lys processing site in native prosomatostatin yielding "mature" alpha-globin.	Lysine	54-57	hemoglobin subunit alpha 2	Homo sapiens	118-130
2500152-10	1989	Both aldose reductase and aldehyde reductase treated with pyridoxal 5-phosphate have lost the susceptibility to aldose reductase inhibitor, suggesting that in these two enzymes aldose reductase inhibitor interacts with a lysine residue.	Lysine	221-227	aldo-keto reductase family 1 member B1	Rattus norvegicus	5-21
2524834-8	1989	Lp(a) binding is lysine-binding site dependent as it is inhibited by epsilon-aminocaproic acid.	Lysine	17-23	lipoprotein(a)	Homo sapiens	0-5
2500152-10	1989	Both aldose reductase and aldehyde reductase treated with pyridoxal 5-phosphate have lost the susceptibility to aldose reductase inhibitor, suggesting that in these two enzymes aldose reductase inhibitor interacts with a lysine residue.	Lysine	221-227	aldo-keto reductase family 1, member B7	Rattus norvegicus	26-44
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Lysine	122-125	angiogenin	Homo sapiens	110-120
2524834-9	1989	Lp(a) inhibits the binding of plasminogen to plasmin-modified immobilized fibrinogen, indicating that both molecules compete for similar lysine-binding sites.	Lysine	137-143	lipoprotein(a)	Homo sapiens	0-5
2500152-10	1989	Both aldose reductase and aldehyde reductase treated with pyridoxal 5-phosphate have lost the susceptibility to aldose reductase inhibitor, suggesting that in these two enzymes aldose reductase inhibitor interacts with a lysine residue.	Lysine	221-227	aldo-keto reductase family 1 member B1	Rattus norvegicus	112-128
2500152-10	1989	Both aldose reductase and aldehyde reductase treated with pyridoxal 5-phosphate have lost the susceptibility to aldose reductase inhibitor, suggesting that in these two enzymes aldose reductase inhibitor interacts with a lysine residue.	Lysine	221-227	aldo-keto reductase family 1 member B1	Rattus norvegicus	112-128
2551057-5	1989	Substituting arginine for lysine at the carboxy-terminus or the 17th residue from the carboxy-terminus decreased the affinity of peptides for plasmin 9-fold and 5-fold, respectively, implicating these lysine residues of AP as major ligand sites for plasmin.	Lysine	26-32	plasminogen	Homo sapiens	142-149
2540167-4	1989	Cathepsin D and calpain I (low calcium-requiring form of calcium-activated neutral protease) rapidly cleaved human placental lipocortin I at Trp-12 and Lys-26, respectively.	Lysine	152-155	cathepsin D	Homo sapiens	0-11
2522013-6	1989	Limited elastase proteolysis of plasminogen and plasmin resulted in the generation of two distinct thrombospondin binding domains, one of which was retained on lysine-agarose.	Lysine	160-166	plasminogen	Homo sapiens	32-39
2551057-5	1989	Substituting arginine for lysine at the carboxy-terminus or the 17th residue from the carboxy-terminus decreased the affinity of peptides for plasmin 9-fold and 5-fold, respectively, implicating these lysine residues of AP as major ligand sites for plasmin.	Lysine	201-207	plasminogen	Homo sapiens	142-149
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Lysine	104-107	thyrotropin releasing hormone	Rattus norvegicus	5-12
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Lysine	104-107	thyrotropin releasing hormone	Rattus norvegicus	84-91
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Lysine	127-130	thyrotropin releasing hormone	Rattus norvegicus	16-19
2551057-5	1989	Substituting arginine for lysine at the carboxy-terminus or the 17th residue from the carboxy-terminus decreased the affinity of peptides for plasmin 9-fold and 5-fold, respectively, implicating these lysine residues of AP as major ligand sites for plasmin.	Lysine	201-207	plasminogen	Homo sapiens	249-256
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Lysine	151-154	thyrotropin releasing hormone	Rattus norvegicus	16-19
2551057-6	1989	Several stepwise increases in affinity of peptides for plasmin as peptide length increased up to 40 residues suggest contributions by additional sites, possibly other lysine residues.	Lysine	167-173	plasminogen	Homo sapiens	55-62
2551057-8	1989	To explain these data, we propose that plasmin recognizes physiological ligands by binding two or more lysine residues which are optimally presented to favor simultaneous interaction with separate lysine-binding site in plasmin.	Lysine	103-109	plasminogen	Homo sapiens	39-46
2551057-8	1989	To explain these data, we propose that plasmin recognizes physiological ligands by binding two or more lysine residues which are optimally presented to favor simultaneous interaction with separate lysine-binding site in plasmin.	Lysine	103-109	plasminogen	Homo sapiens	220-227
2538923-3	1989	This multiubiquitin chain is linked to one of two specific Lys residues in beta gal.	Lysine	59-62	galactosidase beta 1	Homo sapiens	75-83
2551057-8	1989	To explain these data, we propose that plasmin recognizes physiological ligands by binding two or more lysine residues which are optimally presented to favor simultaneous interaction with separate lysine-binding site in plasmin.	Lysine	197-203	plasminogen	Homo sapiens	39-46
2844799-2	1988	Ubiquitinated derivatives of histones H2A and H2B, in which the carboxyl terminus of ubiquitin is joined to epsilon-amino groups of specific lysine residues of each histone, occur in vivo.	Lysine	141-147	H2A clustered histone 18	Homo sapiens	38-41
2538923-4	1989	These same Lys residues have been identified by molecular genetic analysis as components of the aminoterminal degradation signal in beta gal.	Lysine	11-14	galactosidase beta 1	Homo sapiens	132-140
2551057-8	1989	To explain these data, we propose that plasmin recognizes physiological ligands by binding two or more lysine residues which are optimally presented to favor simultaneous interaction with separate lysine-binding site in plasmin.	Lysine	197-203	plasminogen	Homo sapiens	220-227
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Lysine	203-209	plasminogen	Homo sapiens	161-168
2466697-3	1989	C-terminal lysine residues are involved in plasmin binding to cells, since treatment of cells with carboxypeptidase B decreases this binding by 50%.	Lysine	11-17	plasminogen	Homo sapiens	43-50
2902089-8	1988	In the absence of ligands (likely to represent the E1 conformation), trypsin cleaved the 100-kDa ATPase polypeptide at three sites very near the N terminus: Lys-24, Lys-36, and Arg-73.	Lysine	157-160	dynein axonemal heavy chain 8	Homo sapiens	97-103
2902089-8	1988	In the absence of ligands (likely to represent the E1 conformation), trypsin cleaved the 100-kDa ATPase polypeptide at three sites very near the N terminus: Lys-24, Lys-36, and Arg-73.	Lysine	165-168	dynein axonemal heavy chain 8	Homo sapiens	97-103
2660141-3	1989	We show here that substitution of a highly conserved lysine in the presumed ATP-binding site of this domain impairs the derepression of histidine biosynthetic genes under GCN4 control.	Lysine	53-59	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	171-175
2458720-0	1988	Alpha 2-antiplasmin"s carboxy-terminal lysine residue is a major site of interaction with plasmin.	Lysine	39-45	plasminogen	Homo sapiens	12-19
2458720-1	1988	alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme"s active site.	Lysine	97-103	plasminogen	Homo sapiens	12-19
2458720-1	1988	alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme"s active site.	Lysine	97-103	plasminogen	Homo sapiens	34-41
2458720-2	1988	Here, we show that the C-terminal lysine residue of AP has a key role in binding of the inhibitor to plasmin.	Lysine	34-40	plasminogen	Homo sapiens	101-108
2458720-4	1988	The essential role of this lysine residue was shown more directly by treating AP with carboxypeptidase B and observing that AP lost its ability to inhibit plasmin rapidly.	Lysine	27-33	plasminogen	Homo sapiens	155-162
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Lysine	166-172	heme oxygenase 2	Homo sapiens	280-283
2497770-0	1989	Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis.	Lysine	8-15	angiogenin	Homo sapiens	25-35
2497770-1	1989	The role of lysines in the ribonucleolytic and angiogenic activities of human angiogenin has been examined by chemical modification and site-directed mutagenesis.	Lysine	12-19	angiogenin	Homo sapiens	78-88
2540799-3	1989	The following derivatives were analyzed: (i) cytochrome c modified at all 19 lysine residues to yield the (N epsilon-acetimidyl)19 cytochrome c, (N epsilon-isopropyl)19 cytochrome c, and (N epsilon,N epsilon-dimethyl)19 cytochrome c; (ii) cytochrome c in which Met65 and Met80 are converted to the methionine sulfoxide; (iii) cytochrome c with a single break in the polypeptide chain at Arg38 or Gly37.	Lysine	77-83	LOC104968582	Bos taurus	45-57
2538425-1	1989	After incubation of confluent monolayer cultures of human HT-1080 fibrosarcoma cells with purified native human plasminogen in plasminogen-depleted serum-containing medium, bound plasmin activity could be specifically eluted from the cells with tranexamic acid, an analogue of lysine.	Lysine	277-283	plasminogen	Homo sapiens	112-119
3243667-1	1988	The solubility prediction method for protected peptides was successfully applied to relatively small peptide fragments of human hemoglobin alpha-chain (123-136) which contained various polar amino acid residues such as Asp(OBzl), Glu(OBzl), Lys(Z), Ser(Bzl), and Thr(Bzl).	Lysine	241-244	hemoglobin subunit alpha 2	Homo sapiens	128-150
3149742-8	1988	In contrast, lysine-27, another highly reactive residue in bovine GDH, is not conserved in all of the sequenced NADP-specific GDHs and is therefore not likely to be involved in catalysis.	Lysine	13-19	glutamate dehydrogenase 1, mitochondrial	Bos taurus	66-69
2492527-6	1989	Digestion of either PLP-modified or PLP-AMP-modified aldose reductase with endoproteinase Lys-C followed by high performance liquid chromatography purification and amino acid sequencing of the pyridoxyllated peptide revealed that PLP and PLP-AMP had modified the same lysine residue.	Lysine	268-274	pyridoxal phosphatase	Homo sapiens	36-39
2973151-6	1988	Other sulfonamide analogues lacking a para-methylamino reactive group had 10-100 fold less antifibrinolytic potency while lysine, like mafenide, able to compete for plasmin binding sites, could potently block fibrinolysis.	Lysine	122-128	plasminogen	Homo sapiens	165-172
2535487-1	1989	Poly-L-lysine modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP).	Lysine	0-13	dipeptidase 1	Homo sapiens	214-217
2492527-6	1989	Digestion of either PLP-modified or PLP-AMP-modified aldose reductase with endoproteinase Lys-C followed by high performance liquid chromatography purification and amino acid sequencing of the pyridoxyllated peptide revealed that PLP and PLP-AMP had modified the same lysine residue.	Lysine	268-274	pyridoxal phosphatase	Homo sapiens	36-39
2492527-6	1989	Digestion of either PLP-modified or PLP-AMP-modified aldose reductase with endoproteinase Lys-C followed by high performance liquid chromatography purification and amino acid sequencing of the pyridoxyllated peptide revealed that PLP and PLP-AMP had modified the same lysine residue.	Lysine	268-274	pyridoxal phosphatase	Homo sapiens	36-39
2974047-0	1988	Characterization of the intrinsic fibrinolytic properties of pro-urokinase through a study of plasmin-resistant mutant forms produced by site-specific mutagenesis of lysine(158).	Lysine	166-172	plasminogen	Homo sapiens	94-101
2492527-7	1989	A 32-residue peptide containing the essential lysine was found to be highly homologous with a segment of the sequence of both human liver aldehyde reductase and rat lens aldose reductase.	Lysine	46-52	aldo-keto reductase family 1 member B1	Rattus norvegicus	170-186
3060143-2	1988	The alignment indicates that all zymogens have a lysine residue at position p36 (porcine pepsinogen numbering).	Lysine	49-55	5'-nucleotidase, cytosolic IIIA	Homo sapiens	76-79
2465036-5	1989	One epitope has been mapped to the 25-amino acid sequence lys-338 through asp-362 of F.VIII (E338-362).	Lysine	58-61	coagulation factor VIII	Homo sapiens	85-91
3060143-4	1988	It is suggested that Lys (p36) is essential for the correct folding of the zymogen molecule.	Lysine	21-24	5'-nucleotidase, cytosolic IIIA	Homo sapiens	26-29
3394116-6	1988	Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.	Lysine	51-54	plasminogen	Homo sapiens	55-58
3394116-6	1988	Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.	Lysine	51-54	plasminogen	Homo sapiens	55-58
3394116-6	1988	Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.	Lysine	74-77	plasminogen	Homo sapiens	43-46
3179439-8	1988	These data indicate that plasminogen binds to platelets activated in plasma, that binding occurs on platelet GPIIb/IIIa, and that binding may be mediated via plasminogen association with fibrinogen via lysine binding domains.	Lysine	202-208	plasminogen	Homo sapiens	25-36
3179439-8	1988	These data indicate that plasminogen binds to platelets activated in plasma, that binding occurs on platelet GPIIb/IIIa, and that binding may be mediated via plasminogen association with fibrinogen via lysine binding domains.	Lysine	202-208	plasminogen	Homo sapiens	158-169
3394116-6	1988	Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.	Lysine	74-77	plasminogen	Homo sapiens	55-58
2521222-7	1989	The Pg reactive species in a plasmin-treated IgG digest was identified as the Fab fragment by chromatography utilizing the immobilized high affinity lysine-binding site of plasminogen.	Lysine	149-155	plasminogen	Homo sapiens	29-36
3394116-6	1988	Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.	Lysine	74-77	plasminogen	Homo sapiens	55-58
3141482-10	1988	Thus, endothelial cells appear to actively modify circulating Glu-PLG, bind Lys-PLG to their surface, and thus enhance the fibrinolytic potential of the blood vessel wall.	Lysine	76-79	plasminogen	Homo sapiens	80-83
2901984-0	1988	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	Lysine	37-40	pepsinogen A3	Homo sapiens	89-110
2521222-9	1989	These data suggest that Pg binds to the new COOH-terminal lysine residue of the plasmin-derived Fab.	Lysine	58-64	plasminogen	Homo sapiens	80-87
3197838-4	1988	Like human angiogenin, the bovine protein is also homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His-14, Lys-41 and His-115, are conserved.	Lysine	201-204	angiogenin	Homo sapiens	11-21
3143485-13	1988	The five genes, rpl23 (101 codons), rpl2 (278 codons), rps19 (95 codons), rpl22 (114 codons) and rps3 (220 codons) encode lysine-rich polypeptides with predicted molecular weights of 12,152, 31,029, 10,880, 12,819, and 25,238, respectively.	Lysine	122-128	30S ribosomal protein S19	Euglena gracilis	55-60
3221868-13	1988	Surf-3 specifies a highly expressed 1.0-kilobase mRNA that contains a long open reading frame of 266 amino acids, which would encode a highly basic polypeptide (23% Arg plus Lys).	Lysine	174-177	ribosomal protein L7A	Mus musculus	0-6
2839304-1	1988	In Saccharomyces cerevisiae, the functions of two unlinked genes (LYS2 and LYS5) are required for the synthesis of the lysine biosynthetic enzyme, alpha-aminoadipate reductase.	Lysine	119-125	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	66-70
2839304-1	1988	In Saccharomyces cerevisiae, the functions of two unlinked genes (LYS2 and LYS5) are required for the synthesis of the lysine biosynthetic enzyme, alpha-aminoadipate reductase.	Lysine	119-125	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	75-79
2839304-9	1988	The alpha-aminoadipate reductase activity was repressed in lysine-grown wild-type and Lys5+ transformed cells but not in Lys2+ transformed cells.	Lysine	59-65	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	86-90
2964446-9	1988	Thus synthesis and maturation of the alpha-chain of beta-hexosaminidase includes two major proteolytic cleavages: the first, between alanine 22 and leucine 23, removes the signal peptide to generate the precursor form, whereas the second occurs between the dibasic amino acids, lysine 86 and arginine 87.	Lysine	278-284	O-GlcNAcase	Homo sapiens	52-71
3197840-3	1988	Leu-23-Lys-24 is the first bond cleaved during activation of pepsinogen A3.	Lysine	7-10	pepsinogen A3	Homo sapiens	61-74
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Lysine	96-102	plasminogen	Homo sapiens	62-69
3189337-2	1988	The atypical ALDH2(2) gene has a nucleotide base change and produces the defective ALDH2(2) protein, which has a Glu----Lys substitution at the 14th position from the COOH-terminal (Yoshida et al.	Lysine	120-123	aldehyde dehydrogenase 2 family member	Homo sapiens	13-18
3240339-4	1988	Concentrations of CFP-LI were 10-20% those of VIP-LI but could be increased 5-fold by digestion with carboxypeptidase B, suggesting that the C-terminal lysine residue of prepro VIP is not normally removed during processing.	Lysine	152-158	complement factor properdin	Rattus norvegicus	18-21
3189337-2	1988	The atypical ALDH2(2) gene has a nucleotide base change and produces the defective ALDH2(2) protein, which has a Glu----Lys substitution at the 14th position from the COOH-terminal (Yoshida et al.	Lysine	120-123	aldehyde dehydrogenase 2 family member	Homo sapiens	83-88
3196699-8	1988	Arginine and lysine at low concentrations slightly accelerate GFAP assembly, but above 100 mM both amino acids inhibit assembly.	Lysine	13-19	glial fibrillary acidic protein	Bos taurus	62-66
3145818-1	1988	Lysinoalanine [N epsilon-(DL-2-amino-2-carboxyethyl)-L-lysine; LAL], a nephrotoxic lysine analog, inhibits the lysyl-tRNA-synthetase (EC 6.1.1.6) of prokaryotic and eukaryotic cells competitively at micromolar concentrations.	Lysine	55-61	lipase A, lysosomal acid type	Homo sapiens	63-66
3403546-4	1988	The deduced amino acid sequence of cofilin is 166 residues long and contains a sequence of Lys-Lys-Arg-Lys-Lys which is very similar to the nuclear transport signal sequence (Pro-Lys-Lys-Lys-Arg-Lys-Val) of SV40 large T antigen.	Lysine	91-94	cofilin 1	Homo sapiens	35-42
3403546-4	1988	The deduced amino acid sequence of cofilin is 166 residues long and contains a sequence of Lys-Lys-Arg-Lys-Lys which is very similar to the nuclear transport signal sequence (Pro-Lys-Lys-Lys-Arg-Lys-Val) of SV40 large T antigen.	Lysine	95-98	cofilin 1	Homo sapiens	35-42
3403546-4	1988	The deduced amino acid sequence of cofilin is 166 residues long and contains a sequence of Lys-Lys-Arg-Lys-Lys which is very similar to the nuclear transport signal sequence (Pro-Lys-Lys-Lys-Arg-Lys-Val) of SV40 large T antigen.	Lysine	95-98	cofilin 1	Homo sapiens	35-42
3403546-4	1988	The deduced amino acid sequence of cofilin is 166 residues long and contains a sequence of Lys-Lys-Arg-Lys-Lys which is very similar to the nuclear transport signal sequence (Pro-Lys-Lys-Lys-Arg-Lys-Val) of SV40 large T antigen.	Lysine	95-98	cofilin 1	Homo sapiens	35-42
3403546-6	1988	The cofilin sequence contains a hexapeptide (Asp-Ala-Ile-Lys-Lys-Lys) identical to the amino-terminal sequence (residues 2-7) of muscle and nonmuscle tropomyosin.	Lysine	57-60	cofilin 1	Homo sapiens	4-11
3403546-6	1988	The cofilin sequence contains a hexapeptide (Asp-Ala-Ile-Lys-Lys-Lys) identical to the amino-terminal sequence (residues 2-7) of muscle and nonmuscle tropomyosin.	Lysine	61-64	cofilin 1	Homo sapiens	4-11
3403546-6	1988	The cofilin sequence contains a hexapeptide (Asp-Ala-Ile-Lys-Lys-Lys) identical to the amino-terminal sequence (residues 2-7) of muscle and nonmuscle tropomyosin.	Lysine	61-64	cofilin 1	Homo sapiens	4-11
2464382-11	1988	The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE.	Lysine	220-233	surfactant protein A1	Homo sapiens	55-58
3135547-8	1988	The binding site region of PAK2, which also binds Lys, resembles those of PGK1 and PGK4.	Lysine	50-53	p21 (RAC1) activated kinase 2	Homo sapiens	27-31
2456309-3	1988	After treatment with pyroglutamyl aminopeptidase, N-terminal sequencing indicated that Gln74 of MBP formed the N-terminal residue of peptide C. A rabbit antiserum was raised to a synthetic peptide containing the sequence Pyroglu-Lys-Ser-His-Gly-Arg, corresponding to the first six residues of peptide C. By immunoblotting this serum reacted with peptide C but not with intact MBP.	Lysine	229-232	myelin basic protein	Homo sapiens	96-99
3119798-5	1987	Hepatic arginase activity was unaffected by dietary lysine in both strains, whereas hepatic ornithine decarboxylase (ODC) activity fell with increased dietary lysine in the LA strain only.	Lysine	159-165	ornithine decarboxylase	Gallus gallus	117-120
3119798-6	1987	Increasing dietary lysine significantly increased renal arginase activity but reduced renal ODC activity in the HA strain only.	Lysine	19-25	ornithine decarboxylase	Gallus gallus	92-95
2847007-5	1988	All insertions inactivated the LYS2 gene and were able to revert with low (about 10(-8) frequencies to lysine prototrophy.	Lysine	103-109	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	31-35
2977421-10	1988	Binding of plasmin to the bacteria was inhibited by lysine and epsilon-aminocaproic acid in a concentration dependent manner.	Lysine	52-58	plasminogen	Homo sapiens	11-18
2977421-12	1988	These findings suggest a role for plasmin"s high affinity lysine binding site in the interaction of plasmin with the bacteria.	Lysine	58-64	plasminogen	Homo sapiens	34-41
2977421-12	1988	These findings suggest a role for plasmin"s high affinity lysine binding site in the interaction of plasmin with the bacteria.	Lysine	58-64	plasminogen	Homo sapiens	100-107
2968514-2	1988	This gene is on the left arm of linkage group V between caf-1 and lys-1.	Lysine	66-69	chromatin assembly factor 1 subunit A	Homo sapiens	56-61
3479772-2	1987	This is demonstrated by an analysis of velocity autocorrelation functions for the atoms of lysine side chains in the active site of RNase A.	Lysine	91-97	ribonuclease A family member 1, pancreatic	Homo sapiens	132-139
3427134-4	1987	After partial hydrolysis of fibrinogen by plasmin, the amount of adsorbed plasminogen increases and the type of binding changes; part of the proenzyme molecules bind in the presence of 0.003 M 6-aminohexanoic acid, i.e., when lysine-binding sites appear to be blocked.	Lysine	226-232	plasminogen	Homo sapiens	42-49
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Lysine	202-205	insulin receptor	Homo sapiens	30-46
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Lysine	221-224	insulin receptor	Homo sapiens	30-46
2966154-9	1988	Chemical modification of the lysine residues of apolipoprotein B (apoB) by either acetylation or acetoacetylation prevented or diminished the interaction of LDL2 with Lp(a), as shown by both agarose electrophoresis and ligand blotting using modified LDL2.	Lysine	29-35	lipoprotein(a)	Homo sapiens	167-172
2882520-9	1987	Time-course assay showed that D-Trp-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2 (RC-98-I), in a dose of 1 microgram/kg of body weight, inhibited the release of growth hormone for at least 3 hr.	Lysine	50-53	gonadotropin releasing hormone receptor	Rattus norvegicus	150-164
2966154-10	1988	Moreover, removal of the acetoacetyl group from the lysine residues of apoB by hydroxylamine reestablished the interaction of LDL2 with Lp(a).	Lysine	52-58	lipoprotein(a)	Homo sapiens	136-141
2966154-12	1988	Based on these observations, it was concluded that Lp(a) interacts with LDL2 and other apoB-containing lipoproteins which are enriched in triglyceride; this interaction is due to the presence of apolipoprotein(a) and involves lysine residues of apoB interacting with the plasminogen-like domains (kringle 4) of apolipoprotein(a).	Lysine	226-232	lipoprotein(a)	Homo sapiens	51-56
2455942-6	1988	Alternatively, higher yields of VIII:C can be obtained (80% VIII:C and 100% VIII:Ag) by the application of L-lysine gradients (0-0.6M) but with loss of resolution from Fn and slight dissociation of VIII:C from vWf:Ag.	Lysine	107-115	cytochrome c oxidase subunit 8A	Homo sapiens	32-36
3102491-9	1987	These findings suggest that oxidation of LDL is accompanied by derivatization of lysine epsilon-amino groups by lipid products and that these adducts may be important in the interaction of oxidized LDL with the acetyl-LDL receptor.	Lysine	81-87	scavenger receptor class F member 1	Homo sapiens	211-230
2963831-5	1988	Promotion by plasmin was nullified by a subsequent treatment of the clot with carboxypeptidase B, indicating that the plasmin effect was related to the exposure of carboxy terminal lysine residues on fibrin.	Lysine	181-187	plasminogen	Homo sapiens	13-20
2963831-5	1988	Promotion by plasmin was nullified by a subsequent treatment of the clot with carboxypeptidase B, indicating that the plasmin effect was related to the exposure of carboxy terminal lysine residues on fibrin.	Lysine	181-187	plasminogen	Homo sapiens	118-125
3288537-3	1988	Keeping of irradiated cells (in the G1 phase of the cell division cycle) in water at 28 degrees C prior to plating on the selective agar containing 1.5 M KCl leads to smaller frequency of gene conversion lys2-25/lys2-22----Lys+, as compared with that for the cells immediately plated on the selective agar.	Lysine	223-226	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	212-219
3121605-6	1988	In contrast, harmaline functioned as a competitive inhibitor of L-lysine uptake by system asc1 (apparent Ki = 2.6 mM).	Lysine	64-72	solute carrier family 7 member 10	Homo sapiens	90-94
3121605-8	1988	This site does not however bind Na+, the asc1 transporter exhibiting normal L-alanine and L-lysine influx kinetics in the total absence of extracellular cations.	Lysine	90-98	solute carrier family 7 member 10	Homo sapiens	41-45
2943320-6	1986	Plasmin-catalysed transformation of 125I-labelled Glu-1- to Lys-77-plasminogen is quantified following separation by polyacrylamide gel electrophoresis at pH 3.2.	Lysine	60-63	plasminogen	Homo sapiens	0-7
3759562-1	1986	Experiments were designed to determine whether carbamoylation-related inhibition of glutathione reductase (GR) was involved in the previously reported correlation between nitrosourea carbamoylating activity (defined by the extent of binding to L-lysine) and the magnitude of Misonidazole (MISO) chemopotentiation.	Lysine	244-252	glutathione reductase	Mus musculus	84-105
3759562-1	1986	Experiments were designed to determine whether carbamoylation-related inhibition of glutathione reductase (GR) was involved in the previously reported correlation between nitrosourea carbamoylating activity (defined by the extent of binding to L-lysine) and the magnitude of Misonidazole (MISO) chemopotentiation.	Lysine	244-252	glutathione reductase	Mus musculus	107-109
3346544-2	1988	Purified MBP was studied for capacity to regulate the generation of classical and alternative-amplification pathway C3 convertases because previous studies have shown that other polycations (protamine, poly-L-lysine) and polyanions (heparin) may play important roles in regulating C activation.	Lysine	202-215	myelin basic protein	Homo sapiens	9-12
3490629-1	1986	N-Cyclopropyl-4-chloroamphetamine (LY 93716) was examined for its potential preference for inhibiting the activity of monoamine oxidase (MAO) within serotonergic nerve terminals in the hypothalamus of the rat.	Lysine	35-37	monoamine oxidase A	Rattus norvegicus	118-135
3490629-1	1986	N-Cyclopropyl-4-chloroamphetamine (LY 93716) was examined for its potential preference for inhibiting the activity of monoamine oxidase (MAO) within serotonergic nerve terminals in the hypothalamus of the rat.	Lysine	35-37	monoamine oxidase A	Rattus norvegicus	137-140
3280426-13	1988	Glu-plasminogen is easily converted by limited plasmic digestion to modified forms with NH2-terminal lysine, valine or methionine, which are commonly designated "Lys-plasminogen" displaying a plasma half-life time of 0.8 days.	Lysine	101-107	plasminogen	Homo sapiens	4-15
3280426-13	1988	Glu-plasminogen is easily converted by limited plasmic digestion to modified forms with NH2-terminal lysine, valine or methionine, which are commonly designated "Lys-plasminogen" displaying a plasma half-life time of 0.8 days.	Lysine	101-107	plasminogen	Homo sapiens	166-177
2841681-15	1988	However the properties all change to be like those with bovine cytochrome c on addition of poly-L-lysine.	Lysine	91-104	LOC104968582	Bos taurus	63-75
3126814-1	1988	Reductive methylation of bovine brain derived acidic fibroblast growth factor (aFGF) with formaldehyde and sodium cyanoborohydride reduces its capacity to stimulate mitogenesis in Balb/C 3T3 cells, and this correlates with the modification of less than 3 of its 12 lysine residues.	Lysine	265-271	fibroblast growth factor 1	Bos taurus	79-83
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Lysine	167-173	plasminogen	Homo sapiens	143-146
2979011-3	1988	Acetaldehyde inhibits the plasmin activity towards casein, fibrin and H-D-Val-Leu-Lys-pNA.	Lysine	82-86	plasminogen	Homo sapiens	26-33
3275655-5	1988	It hydrolyzes synthetic substrates at carbonyl bonds of Arg or Lys residues, and the hydrolysis is strongly inhibited by diisopropylfluorophosphate, phenylmethanesulfonyl fluoride, and leupeptin, suggesting that it is a trypsin-like protease.	Lysine	63-66	trypsin-like protease	Bombyx mori	220-241
2472003-5	1988	The sequence shared by the otherwise unrelated DR1 and DR4 haplotypes from residue 67 in the DR a chain that appears to confer susceptibility is Leu-X-X-Gln-Arg/Lys.	Lysine	161-164	down-regulator of transcription 1	Homo sapiens	47-50
3745142-7	1986	These results indicated that the plasminogen-binding site(s) of alpha 2-plasmin inhibitor could be located in the COOH-terminal region of its molecule and that some of epsilon-NH2-groups in the deamidinated peptide T-11 may be involved in the lysine-binding site(s) of plasmin(ogen).	Lysine	243-249	plasminogen	Homo sapiens	33-40
2960974-1	1987	A catalytically active, human microplasmin was produced by incubation of [Lys]plasmin in buffer at pH 11.0 for up to 12 hr.	Lysine	74-77	plasminogen	Homo sapiens	35-42
4074786-11	1985	The data on the combined effect of DEP and pyridoxal-5"-phosphate suggest that GDH inactivation by DEP at pH 7.5 is a result of modification of an essential epsilon-NH2 group of lysine-126.	Lysine	178-184	glutamate dehydrogenase 1, mitochondrial	Bos taurus	79-82
3320345-10	1987	Total blockade of quipazine-induced renin secretion was produced by LY 53857 at 0.003 mg/kg, and the response was still reduced by 50% at 0.001 mg/kg.	Lysine	68-70	renin	Rattus norvegicus	36-41
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Lysine	201-204	troponin I, fast skeletal muscle	Oryctolagus cuniculus	74-77
3320345-12	1987	The 10-fold difference in the dose of LY 53857 necessary to block the pressor and renin responses may be due to subtle differences in receptor subtypes, or to pharmacokinetic properties favoring antagonism of quipazine-induced renin secretion.	Lysine	38-40	renin	Rattus norvegicus	82-87
3320345-12	1987	The 10-fold difference in the dose of LY 53857 necessary to block the pressor and renin responses may be due to subtle differences in receptor subtypes, or to pharmacokinetic properties favoring antagonism of quipazine-induced renin secretion.	Lysine	38-40	renin	Rattus norvegicus	227-232
3935863-3	1985	Both sera were however reactive with GnRH-Lys-muramyl dipeptide analogue and GnRH-Ala-Ala-Thr-Lys-Pro-Arg-OH.	Lysine	42-45	gonadotropin releasing hormone 1	Homo sapiens	37-41
2445046-6	1987	Leukocyte elastase digests plasminogen "in vitro" and is able to produce several fragments; one of them called mini-plasminogen lacking lysine binding sites; therefore it does not bind to lysine-Sepharose 4B.	Lysine	136-142	elastase, neutrophil expressed	Homo sapiens	0-18
4029086-0	1985	Variables determining the growth hormone response of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the rat.	Lysine	77-80	gonadotropin releasing hormone receptor	Rattus norvegicus	26-40
3122207-0	1987	Ribonucleolytic activity of angiogenin: essential histidine, lysine, and arginine residues.	Lysine	61-67	angiogenin	Homo sapiens	28-38
3122207-2	1987	Reagents specific for histidine, lysine, and arginine markedly decrease the ribonucleolytic activity of angiogenin, much as has been observed for RNase A.	Lysine	33-39	angiogenin	Homo sapiens	104-114
3122207-5	1987	From the point of view of reactivity, the histidine and lysine residues in angiogenin are severalfold less susceptible to modification than those in RNase A.	Lysine	56-62	angiogenin	Homo sapiens	75-85
2821651-1	1987	Plasminogen kringle 1+2+3 (K1-3) containing lysine-binding sites inhibited the reaction of plasmin with alpha 2-plasmin inhibitor (alpha 2PI), in a rate assay using a synthetic chromogenic substrate, S-2251.	Lysine	44-50	keratin 1	Homo sapiens	27-31
3678488-5	1987	Here again, this peptide, occupying positions 597-653 and located at the COOH-terminal region of chromogranin B, could derive from specific processing at basic amino acids, Arg-Lys-Lys, present at positions 594-596.	Lysine	177-180	chromogranin B	Homo sapiens	97-111
3678488-5	1987	Here again, this peptide, occupying positions 597-653 and located at the COOH-terminal region of chromogranin B, could derive from specific processing at basic amino acids, Arg-Lys-Lys, present at positions 594-596.	Lysine	181-184	chromogranin B	Homo sapiens	97-111
2998332-2	1985	The amino acid composition of caldesmon is distinct from that of myosin light-chain kinase and is characterized by a very high glutamic acid content (25.5%), high contents of lysine (13.6%) and arginine (10.3%), and a low aromatic amino acid content (2.4%).	Lysine	175-181	caldesmon 1	Gallus gallus	30-39
2821651-1	1987	Plasminogen kringle 1+2+3 (K1-3) containing lysine-binding sites inhibited the reaction of plasmin with alpha 2-plasmin inhibitor (alpha 2PI), in a rate assay using a synthetic chromogenic substrate, S-2251.	Lysine	44-50	plasminogen	Homo sapiens	91-98
3929378-1	1985	A rabbit antiserum to a peptide sequence present in the precursor for thyrotropin-releasing hormone (proTRH), deduced from cloned amphibian-skin complementary DNA, was raised by immunization with the synthetic decapeptide Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys (proTRH-SH).	Lysine	226-229	thyrotropin releasing hormone	Rattus norvegicus	70-99
3115654-4	1987	The inhibitor was shown to be a globulin that was labile at 56 degrees C and bound to lysine; low concentrations of tranexamic acid and of lysine abolished the effects of the inhibitor which suggests that it possesses lysine-binding sites: these may block the CR1-binding site on IC opsonized with complement.	Lysine	139-145	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	260-263
3115654-4	1987	The inhibitor was shown to be a globulin that was labile at 56 degrees C and bound to lysine; low concentrations of tranexamic acid and of lysine abolished the effects of the inhibitor which suggests that it possesses lysine-binding sites: these may block the CR1-binding site on IC opsonized with complement.	Lysine	139-145	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	260-263
3929378-1	1985	A rabbit antiserum to a peptide sequence present in the precursor for thyrotropin-releasing hormone (proTRH), deduced from cloned amphibian-skin complementary DNA, was raised by immunization with the synthetic decapeptide Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys (proTRH-SH).	Lysine	250-253	thyrotropin releasing hormone	Rattus norvegicus	70-99
2821651-3	1987	These results suggest that K1-3 blocked the binding of alpha 2PI to the lysine-binding site of plasmin.	Lysine	72-78	keratin 1	Homo sapiens	27-31
2821651-3	1987	These results suggest that K1-3 blocked the binding of alpha 2PI to the lysine-binding site of plasmin.	Lysine	72-78	plasminogen	Homo sapiens	95-102
2821651-8	1987	The above findings indicate that the reaction of alpha 2PI with the lysine-binding site of plasmin is involved in the inhibition of plasmin activity by alpha 2PI, and in the presence of an inhibitor of this reaction, the balance of coagulofibrinolytic activity in plasma will be shifted towards the fibrinolytic side.	Lysine	68-74	plasminogen	Homo sapiens	91-98
2821651-8	1987	The above findings indicate that the reaction of alpha 2PI with the lysine-binding site of plasmin is involved in the inhibition of plasmin activity by alpha 2PI, and in the presence of an inhibitor of this reaction, the balance of coagulofibrinolytic activity in plasma will be shifted towards the fibrinolytic side.	Lysine	68-74	plasminogen	Homo sapiens	132-139
3928488-1	1985	Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action.	Lysine	106-109	renin	Rattus norvegicus	14-19
3031028-4	1987	Treatment of surface-bound 125I-hemopexin with divalent lysine-directed cross-linking disuccinimidyl suberate revealed a membrane polypeptide of about 80,000 Da, to which hemopexin is cross-linked.	Lysine	56-62	hemopexin	Homo sapiens	32-41
3031028-4	1987	Treatment of surface-bound 125I-hemopexin with divalent lysine-directed cross-linking disuccinimidyl suberate revealed a membrane polypeptide of about 80,000 Da, to which hemopexin is cross-linked.	Lysine	56-62	hemopexin	Homo sapiens	171-180
3109484-6	1987	Similarly, Lys-220 (NH3+) of chymosin and a Glu (COO-) in P2 of a substrate may produce a favorable interaction and Asp-77 (COO-) of E. parasitica proteinase and a Glu (COO-) in P2 of a substrate may produce an unfavorable interaction.	Lysine	11-14	chymosin	Bos taurus	29-37
3921525-6	1985	Our results demonstrate that the anabolism of high levels of alpha-aminoadipate through the biosynthetic pathway of lysine results in the accumulation of a toxic intermediate and, furthermore, that lys2 and lys5 mutants contain blocks leading to the formation of this intermediate.	Lysine	116-122	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	198-202
3921525-6	1985	Our results demonstrate that the anabolism of high levels of alpha-aminoadipate through the biosynthetic pathway of lysine results in the accumulation of a toxic intermediate and, furthermore, that lys2 and lys5 mutants contain blocks leading to the formation of this intermediate.	Lysine	116-122	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	207-211
3031680-5	1987	The deduced amino acid sequence is rich in lysine, which is consistent with the relatively high pI of GST-2.	Lysine	43-49	glutathione S-transferase alpha 1	Homo sapiens	102-107
3109909-2	1987	Peptides related to TRH were detected by trypsin digestion and radioimmunoassay with an antibody to TRH or an antibody raised against the pentapeptide Glp-His-Pro-Gly-Lys.	Lysine	167-170	thyrotropin releasing hormone	Rattus norvegicus	20-23
2946323-2	1986	Since fragment Y is the last peptide product which reacts with anti-beta 43-47 antibodies, splitting of fragment Y into fragment D and fragment E must be accompanied by plasmin cleavage of the peptide bond beta Lys-47-Ala-48.	Lysine	211-214	plasminogen	Homo sapiens	169-176
3973931-4	1985	The growth cones of most of the continuously NGF-treated DRG neurons (cultured on poly-L-lysine or collagen-coated glass coverslips) had relatively compact central flattened areas and numerous prominent filopodia.	Lysine	82-95	nerve growth factor	Rattus norvegicus	45-48
2950927-2	1987	Changes in the ATPase activities upon modification occur rapidly, paralleling the reaction of "fast reacting lysine residues" during the fast phase of the reaction.	Lysine	109-115	dynein axonemal heavy chain 8	Homo sapiens	15-21
6096007-3	1984	The implication that the sequence element around Lys-128 acts as an autonomous signal capable of specifying nuclear location was tested directly by transferring it to the amino termini of beta-galactosidase and of pyruvate kinase, normally a cytoplasmic protein.	Lysine	49-52	galactosidase beta 1	Homo sapiens	188-206
2946332-0	1986	Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions.	Lysine	77-83	plasminogen	Homo sapiens	43-50
2946332-0	1986	Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions.	Lysine	77-83	plasminogen	Homo sapiens	69-76
2946332-3	1986	epsilon-Aminocaproic acid (EACA) inhibited plasmin release of glycocalicin-related antigen from washed platelets and preserved vWF-dependent platelet agglutination, thus indicating that the lysine-binding sites on plasmin facilitated its degradation of GpIb.	Lysine	190-196	plasminogen	Homo sapiens	43-50
2946332-3	1986	epsilon-Aminocaproic acid (EACA) inhibited plasmin release of glycocalicin-related antigen from washed platelets and preserved vWF-dependent platelet agglutination, thus indicating that the lysine-binding sites on plasmin facilitated its degradation of GpIb.	Lysine	190-196	plasminogen	Homo sapiens	214-221
2946332-7	1986	These studies indicated that plasmin degradation of GpIb was due to a direct interaction between plasmin and GpIb and that this effect was mediated by the lysine-binding region of the plasmin molecule.	Lysine	155-161	plasminogen	Homo sapiens	29-36
3298096-1	1987	Two glycopeptides associating the aminoacid sequence of LH-RH with MDP were prepared, using a Lys residue as a linker.	Lysine	94-97	gonadotropin releasing hormone 1	Homo sapiens	56-61
3768376-7	1986	These results show that the micelle binding site is not limited to the tyrosine residues but may be broadened to adjacent residues such as lysine 60 and also tryptophan 52 in horse colipase.	Lysine	139-145	colipase	Equus caballus	181-189
6377304-4	1984	In the case of elongation factor Tu X GDP X kirromycin, cross-linking was found at lysine-208; in elongation factor Tu X GTP X kirromycin, cross-linking was at lysine-208 and lysine-237.	Lysine	83-89	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	15-35
6377304-4	1984	In the case of elongation factor Tu X GDP X kirromycin, cross-linking was found at lysine-208; in elongation factor Tu X GTP X kirromycin, cross-linking was at lysine-208 and lysine-237.	Lysine	160-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	98-118
6377304-4	1984	In the case of elongation factor Tu X GDP X kirromycin, cross-linking was found at lysine-208; in elongation factor Tu X GTP X kirromycin, cross-linking was at lysine-208 and lysine-237.	Lysine	160-166	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	98-118
3101064-0	1987	Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.	Lysine	15-21	insulin receptor	Homo sapiens	77-93
6424712-0	1984	Modification of a lysine residue of adrenodoxin reductase, essential for complex formation with adrenodoxin.	Lysine	18-24	ferredoxin reductase	Homo sapiens	36-57
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	ferredoxin reductase	Homo sapiens	51-72
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Lysine	79-82	insulin receptor	Homo sapiens	31-47
3091599-11	1986	In conjunction with previously published data, these results are interpreted as suggesting that the major perturbation in lysine 75 is a direct effect of MLC kinase contact with CaM and that a region in the central helix containing this residue, but not lysine 77, represents or is near the CaM-binding site for MLC kinase.	Lysine	122-128	myosin light chain kinase 3	Homo sapiens	154-164
3091599-12	1986	The smaller changes in reactivities at lysines 21 and 148 may reflect a conformational change that occurs in CaM as a result of binding to MLC kinase.	Lysine	39-46	myosin light chain kinase 3	Homo sapiens	139-149
6424712-4	1984	One lysine residue of the adrenodoxin reductase could be protected from the modification with pyridoxal 5"-phosphate by complex formation with adrenodoxin.	Lysine	4-10	ferredoxin reductase	Homo sapiens	26-47
3101064-1	1987	To test whether the tyrosine kinase activity of the insulin receptor is crucial for insulin action, we have constructed mutations of the human insulin receptor at Lys-1030, which is in the presumed ATP-binding region.	Lysine	163-166	insulin receptor	Homo sapiens	52-68
3101064-1	1987	To test whether the tyrosine kinase activity of the insulin receptor is crucial for insulin action, we have constructed mutations of the human insulin receptor at Lys-1030, which is in the presumed ATP-binding region.	Lysine	163-166	insulin receptor	Homo sapiens	143-159
3667318-0	1987	Identification of Hb Lepore-Washington-Boston in association with Hb E [beta 26(B8)Glu----Lys] in a Thai female.	Lysine	90-93	hemoglobin subunit epsilon 1	Homo sapiens	66-70
6370138-7	1984	This cationic region, probably due to lysine and/or arginine residues, may serve in vivo to facilitate the interaction between hydrogenase and ferredoxin, the polyanionic, physiological electron mediator.	Lysine	38-44	uncharacterized protein	Chlamydomonas reinhardtii	143-153
6546689-3	1984	The carboxyl terminal sequence of this fragment -Cys-Gln-Leu-Gln is found on the N-terminal side of a lys residue, suggesting that the peptide bond cleavage which occurs to produce this 80 residue fragment from the parent (330K) thyroglobulin chain is a gln-lys.	Lysine	102-105	thyroglobulin	Bos taurus	229-242
6546689-3	1984	The carboxyl terminal sequence of this fragment -Cys-Gln-Leu-Gln is found on the N-terminal side of a lys residue, suggesting that the peptide bond cleavage which occurs to produce this 80 residue fragment from the parent (330K) thyroglobulin chain is a gln-lys.	Lysine	258-261	thyroglobulin	Bos taurus	229-242
3023949-5	1986	The level of the LYS2 transcript (4.2 kb) was 10-fold higher in cells grown on minimal medium than in cells grown on complete medium and was not repressed by the presence of lysine alone.	Lysine	174-180	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	17-21
3023949-7	1986	Because all fungi synthesize lysine via the alpha-aminoadipate pathway, the techniques developed here for using the S. cerevisiae LYS2 gene should be directly applicable to other fungal systems.	Lysine	29-35	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	130-134
3667318-4	1987	Amino acid analysis of selected peptides permitted unambiguous identification of the abnormal hemoglobins as Hb E [beta 26(B8)Glu----Lys] and Hb Lepore-Washington-Boston, which has a delta chain sequence for residues 1-87, and a beta chain sequence for residues 116-146.	Lysine	133-136	hemoglobin subunit epsilon 1	Homo sapiens	109-113
3021733-5	1986	Although the exact number and site of the cross-linked location were not determinable, in cytochrome c the amide bond originates from Lys-13 and in reductase it might be at any one of six different side chain carboxyl groups in the two neighboring cluster acidic residues, Asp-207, -208, and -209, and Glu-213, Glu-214, and Asp-215.	Lysine	134-137	cytochrome c	Oryctolagus cuniculus	90-102
6365905-9	1984	The cross-links were found to involve the formation of amide linkages between carboxyl groups on adrenodoxin and the lysine amino groups surrounding the heme crevice of cytochrome c.	Lysine	117-123	LOC104968582	Bos taurus	169-181
2871191-9	1986	The other MTX analogues and the previously reported lysine derivative (mAPA-Lys) showed DHFR affinity similar to that of mAPA-Orn but lacked activity as FPGS inhibitors.	Lysine	52-58	glutamyl aminopeptidase	Mus musculus	71-75
3536000-1	1986	We report results of chromatographic, pH titration and nuclear magnetic resonance (NMR) spectroscopy studies demonstrating that the bovine pineal antireproductive tripeptide, Thr-Ser-Lys (BPART), binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 (His-Trp-Ser-Tyr).	Lysine	183-186	gonadotropin releasing hormone 1	Homo sapiens	205-242
2871191-9	1986	The other MTX analogues and the previously reported lysine derivative (mAPA-Lys) showed DHFR affinity similar to that of mAPA-Orn but lacked activity as FPGS inhibitors.	Lysine	52-58	glutamyl aminopeptidase	Mus musculus	121-125
2420275-5	1986	These results, and other spectral evidence, suggested that head groups in free PG vesicles are motionally restricted by intermolecular interactions which are disrupted by competition with MBP Lys and Arg positively charged side chains.	Lysine	192-195	myelin basic protein	Homo sapiens	188-191
6322690-5	1984	Chlamydomonas calmodulin lacks trimethyllysine but does have a lysine residue at the amino acid sequence position corresponding to the trimethyllysine residue in bovine brain and spinach calmodulins.	Lysine	40-46	uncharacterized protein	Chlamydomonas reinhardtii	14-24
6639687-13	1983	Lysine, arginine, L-canavanine and polymyxin B all affected NAG release from lysosomes in vitro.	Lysine	0-6	O-GlcNAcase	Rattus norvegicus	60-63
3536000-1	1986	We report results of chromatographic, pH titration and nuclear magnetic resonance (NMR) spectroscopy studies demonstrating that the bovine pineal antireproductive tripeptide, Thr-Ser-Lys (BPART), binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 (His-Trp-Ser-Tyr).	Lysine	183-186	gonadotropin releasing hormone 1	Homo sapiens	244-248
3536000-1	1986	We report results of chromatographic, pH titration and nuclear magnetic resonance (NMR) spectroscopy studies demonstrating that the bovine pineal antireproductive tripeptide, Thr-Ser-Lys (BPART), binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5 (His-Trp-Ser-Tyr).	Lysine	183-186	gonadotropin releasing hormone 1	Homo sapiens	273-277
3745161-7	1986	Binding of PLG was 70-80% inhibited by 10 mM epsilon-aminocaproic acid, suggesting that it is largely mediated by the lysine-binding sites of PLG.	Lysine	118-124	plasminogen	Homo sapiens	11-14
6091698-4	1983	The synthesis of cytochrome-c-Sepharose was carried out in a way preventing modification of the lysine-containing binding domain of the cytochrome c molecule.	Lysine	96-102	LOC104968582	Bos taurus	136-148
3542721-5	1986	The proper functioning of the LYS2 cartridges was demonstrated by the transformation of lys2 mutant strains to Lys+ prototrophy using plasmids furnished with a LYS2 cartridge.	Lysine	111-114	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	30-34
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Lysine	81-89	plasminogen	Homo sapiens	142-149
3745161-7	1986	Binding of PLG was 70-80% inhibited by 10 mM epsilon-aminocaproic acid, suggesting that it is largely mediated by the lysine-binding sites of PLG.	Lysine	118-124	plasminogen	Homo sapiens	142-145
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Lysine	81-89	plasminogen	Homo sapiens	283-290
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Lysine	81-89	plasminogen	Homo sapiens	283-290
6883721-4	1983	Biotinidase catalyzes the removal of biotin from the epsilon-amino group of lysine, through which biotin is covalently bound to the four known human carboxylases, thereby regenerating biotin for reutilization.	Lysine	76-82	biotinidase	Homo sapiens	0-11
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Lysine	143-146	angiogenin	Homo sapiens	45-55
6752121-3	1982	Mutants belonging to the lys2 and lys14 loci were able to grow in lysine-supplemented alpha-aminoadipate medium, although not as well as when selected amino acids were added.	Lysine	66-72	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	25-29
2424496-6	1986	The high degree of sequence homology between angiogenin and the pancreatic ribonucleases, which includes all three catalytic residues, His-12, Lys-41, and His-119, has thus identified the chemical nature of a potential angiogenin substrate.	Lysine	143-146	angiogenin	Homo sapiens	219-229
3700427-10	1986	Three moles of methyl/mol of calmodulin were incorporated into lysine 115 of des(methyl)calmodulin, resulting in the formation of 1 mol of trimethyllysine at the site normally methylated in calmodulins from most species.	Lysine	63-69	calmodulin 1	Rattus norvegicus	29-39
7155144-1	1982	Schiff bases condensible at pH 7.0-10 after prolonged incubation with neighbouring histidine residues to yield cyclic compounds absorbing at 330 nm are formed by means of four molecules of pyridoxal-5"-phosphate (PLP) interacting with epsilon-NH2 groups of lysine in bovine serum albumin.	Lysine	257-263	pyridoxal phosphatase	Homo sapiens	213-216
6806298-2	1982	The site is involved with, at least, two modes of action: the imidazole catalysis of His beta 2 and the irreversible covalent acetylation of Lys beta 82.	Lysine	141-144	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
4088430-5	1985	Against the background of general similarity the concentration of some amino acids such as lysine, proline, tyrosine in PLP somewhat increased during development, while that of aspartic acid, glutamic acid, glycine, and leucine decreased.	Lysine	91-97	proteolipid protein 1	Rattus norvegicus	120-123
4071469-7	1985	Circular dichroism spectra indicated that the secondary and tertiary structure of Glu-plg changed after acidification, and that only the tertiary structure of Lys-plg changed.	Lysine	159-162	plasminogen	Homo sapiens	163-166
3700427-10	1986	Three moles of methyl/mol of calmodulin were incorporated into lysine 115 of des(methyl)calmodulin, resulting in the formation of 1 mol of trimethyllysine at the site normally methylated in calmodulins from most species.	Lysine	63-69	calmodulin 1	Rattus norvegicus	88-98
2940088-2	1986	One of thirty murine monoclonal antibodies, raised by immunization with human plasmin-alpha 2-antiplasmin complex, was found to be directed against the high-affinity lysine-binding site in plasminogen.	Lysine	166-172	plasminogen	Homo sapiens	78-85
2931434-10	1985	In addition, firm evidence was found that upon activation by plasmin single-chain pro-urokinase is cleaved at the Lys-Ile bond between residues 158 and 159, resulting in the formation of a two-chain urokinase molecule held together by one disulfide linkage.	Lysine	114-117	plasminogen	Homo sapiens	61-68
3161540-0	1985	Quantitative characterization of the binding of plasminogen to intact fibrin clots, lysine-sepharose, and fibrin cleaved by plasmin.	Lysine	84-90	plasminogen	Homo sapiens	48-55
6180314-4	1982	The NH2-terminal primary structure of turkey beta 2m is: NH2-Lys-Ile-Glu-Val-Tyr-Ile-Lys-.	Lysine	61-64	beta-2-microglobulin	Meleagris gallopavo	45-52
3082877-3	1986	The C-terminal, cytoplasmic peptide domain of the IL-2 receptor, Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile, was synthesized and used as a substrate for protein kinase C. The Km for phosphorylation of the peptide by protein kinase C was 23 microM.	Lysine	85-88	interleukin 2 receptor subunit beta	Homo sapiens	50-63
6279643-9	1982	On the basis of amino acid composition, the tryptic peptides carrying the minor phosphorylation sites were identified as H-Leu-Ser(P)-Ala-Lys representing residues 23-26 and 27-30 of HMG 14 and HMG 17, respectively.	Lysine	138-141	high mobility group nucleosome binding domain 1	Homo sapiens	183-189
7200268-5	1982	It was possible to elute the activators and mini-plasminogen and plasmin which required 1 M lysine for elution, suggesting specific binding involving lysine binding sites.	Lysine	92-98	plasminogen	Homo sapiens	49-56
7200268-5	1982	It was possible to elute the activators and mini-plasminogen and plasmin which required 1 M lysine for elution, suggesting specific binding involving lysine binding sites.	Lysine	150-156	plasminogen	Homo sapiens	49-56
3161540-1	1985	The binding of human Glu- and Lys-plasminogens to intact fibrin clots, to lysine-Sepharose, and to fibrin cleaved by plasmin was quantitatively characterized.	Lysine	74-80	plasminogen	Homo sapiens	34-41
3161540-10	1985	Acta 258, 577-590], because the structures of the lysyl moiety in lysine-Sepharose and of epsilon-aminocaproic acid are identical with the structure of a COOH-terminal lysyl residue created by plasmin cleavage of fibrin.	Lysine	66-72	plasminogen	Homo sapiens	193-200
3923474-4	1985	Accordingly, 3"-oxidized tRNA can be cross-linked in the presence of the antibiotic to two specific sites of EF-Tu: Lys-237 and Lys-208.	Lysine	116-119	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	109-114
3923474-4	1985	Accordingly, 3"-oxidized tRNA can be cross-linked in the presence of the antibiotic to two specific sites of EF-Tu: Lys-237 and Lys-208.	Lysine	128-131	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	109-114
2938303-5	1986	Thus, it was demonstrated that enzymatic properties of plasmin are to some extent dependent on the presence of lysine-binding sites.	Lysine	111-117	plasminogen	Homo sapiens	55-62
3917922-2	1985	The flavoprotein ferredoxin-NADP+ reductase is inactivated and loses its ability to bind NADP+ during covalent modification of a lysine by 5-dimethylaminonaphthalene-1-sulfonyl chloride (dansyl chloride) [Zanetti, G. (1976) Biochim.	Lysine	129-135	ferredoxin reductase	Homo sapiens	17-43
6280699-0	1982	Existence of lysine-derived cross-linking in connectin, an elastic protein in muscle.	Lysine	13-19	titin	Homo sapiens	45-54
3542721-5	1986	The proper functioning of the LYS2 cartridges was demonstrated by the transformation of lys2 mutant strains to Lys+ prototrophy using plasmids furnished with a LYS2 cartridge.	Lysine	111-114	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	88-92
3542721-5	1986	The proper functioning of the LYS2 cartridges was demonstrated by the transformation of lys2 mutant strains to Lys+ prototrophy using plasmids furnished with a LYS2 cartridge.	Lysine	111-114	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	160-164
6173445-3	1982	The latter exposure was facilitated by SWAP adsorption to the culture vessel via poly-L-lysine.	Lysine	81-94	splicing factor SWAP	Mus musculus	39-43
3928261-5	1985	The gene-enzyme relationships have been determined for ten of the lysine loci which include two unlinked gene functions required for each of AA reductase (LYS2 and LYS5) and Saccharopine reductase (LYS9 and LYS14).	Lysine	66-72	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	155-159
3928261-5	1985	The gene-enzyme relationships have been determined for ten of the lysine loci which include two unlinked gene functions required for each of AA reductase (LYS2 and LYS5) and Saccharopine reductase (LYS9 and LYS14).	Lysine	66-72	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	164-168
2999782-6	1985	These results show that lysine-121 is required for the ability of p37mos to transform cells and provide evidence for an ATP-binding site in p37mos.	Lysine	24-30	nucleoporin 37	Homo sapiens	66-69
4029755-6	1985	This effect could be neutralized, and to some extent, regulated, by lys-PLG enrichment of the medium.	Lysine	68-71	plasminogen	Homo sapiens	72-75
6270085-10	1981	In contrast, previous work on the modification of lysine 42 in LH-beta which lies in an analogous domain implicates that residue in receptor interaction (e.g. Liu, W.-K., Yang, K.-P., Nakagawa, Y., and Ward, D. N. (1974) J. Biol.	Lysine	50-56	lutropin subunit beta	Bos taurus	63-70
6787182-1	1981	We examined the ability of wheat gluten or casein diets supplemented with arginine, indispensable (IAA) or branched-chain (BCAA) amino acids (inhibitors of lysine transport into brain slices in vitro) to induce changes in tissue lysine concentrations consistent with occurrence of lysine imbalance.	Lysine	156-162	AT-rich interaction domain 4B	Rattus norvegicus	123-127
6787182-5	1981	Growth depressions caused by supplements of BCAA or IAA were frequently accompanied by small or insignificant decreases in brain lysine content, and by small increases in tissue content of these amino acids.	Lysine	129-135	AT-rich interaction domain 4B	Rattus norvegicus	44-48
4074360-1	1985	A radioactive photoaffinity probe for the insulin receptor was prepared by derivatizing insulin at its B29 lysine with a novel crosslinking reagent having a cleavable azo linkage.	Lysine	107-113	insulin receptor	Homo sapiens	42-58
6438154-7	1984	In both ELISA and rocket immunoelectrophoresis systems, complex formation was inhibited by 10 mM epsilon-amino-n-caproic acid, implying that there is a role for the lysine binding sites of Plg in mediating the interaction.	Lysine	165-171	plasminogen	Homo sapiens	189-192
2997189-0	1985	Effect of modification of lysine residues of fructose-6-phosphate 2-kinase:fructose-2,6-bisphosphatase with pyridoxal 5"-phosphate.	Lysine	26-32	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Homo sapiens	45-102
6090951-6	1984	These DNA sequences code for a protein of 92 amino acids in which the LHRH decapeptide is preceded by a signal peptide of 23 amino acids and followed by a Gly-Lys-Arg sequence, as expected for enzymatic cleavage of the decapeptide from its precursor and amidation of the carboxy-terminal of LHRH.	Lysine	159-162	gonadotropin releasing hormone 1	Homo sapiens	70-74
6452897-2	1981	Titration experiments of IF1 by (14C)MABI and tryptic maps of (14C)MABI-IF1 indicated that specific lysine residues in IF1 are preferentially labeled by (14C)MABI.	Lysine	100-106	ATP synthase inhibitory factor subunit 1	Homo sapiens	25-28
6452897-2	1981	Titration experiments of IF1 by (14C)MABI and tryptic maps of (14C)MABI-IF1 indicated that specific lysine residues in IF1 are preferentially labeled by (14C)MABI.	Lysine	100-106	ATP synthase inhibitory factor subunit 1	Homo sapiens	72-75
6452897-2	1981	Titration experiments of IF1 by (14C)MABI and tryptic maps of (14C)MABI-IF1 indicated that specific lysine residues in IF1 are preferentially labeled by (14C)MABI.	Lysine	100-106	ATP synthase inhibitory factor subunit 1	Homo sapiens	72-75
6452897-3	1981	Under appropriate conditions of labeling (1 to 2 lysine residues modified per IF1), MABI-IF1 exhibited the same inhibitory potency as native IF1 on the hydrolytic activity of the coupling factor 1 of mitochondrial ATPase (F1).	Lysine	49-55	ATP synthase inhibitory factor subunit 1	Homo sapiens	89-92
6452897-3	1981	Under appropriate conditions of labeling (1 to 2 lysine residues modified per IF1), MABI-IF1 exhibited the same inhibitory potency as native IF1 on the hydrolytic activity of the coupling factor 1 of mitochondrial ATPase (F1).	Lysine	49-55	ATP synthase inhibitory factor subunit 1	Homo sapiens	89-92
2933845-3	1985	Especially the conversion of Glu-plg II to Lys-plg II by plasmin took place very slowly.	Lysine	43-46	plasminogen	Homo sapiens	57-64
7043993-4	1981	Poly-L-lysine was found to specifically inhibit ATP-dependent activity although it is a poor substrate for this system.	Lysine	0-13	ATPase phospholipid transporting 8A2	Homo sapiens	48-51
6253494-3	1980	Specific carboxymethylation of Lys-41 of RNase A decreased the strength of the interaction between the enzyme and the RNase inhibitor to about 12% of the initial value.	Lysine	31-34	ribonuclease A family member 1, pancreatic	Homo sapiens	41-48
6383483-0	1984	Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.	Lysine	159-165	Cd47 molecule	Rattus norvegicus	76-100
6383483-7	1984	On the other hand, additional effects of IAP, such as (1) mitogenic, (2) lymphocytosis-promoting, (3) histamine-sensitizing, (4) adjuvant and (5) vascular permeability increasing, were markedly suppressed by acetamidination of the intrapeptide lysine residues.	Lysine	244-250	Cd47 molecule	Rattus norvegicus	41-44
6383483-8	1984	The free epsilon-amino group of lysine would play an indispensable role in the firm (or divalent) attachment of the B-oligomer of IAP to the cell surface that is responsible for development of these activities.	Lysine	32-38	Cd47 molecule	Rattus norvegicus	130-133
6541059-3	1984	Acetamidination of epsilon-amino groups of 50% (or more) of lysine residues in the IAP molecule totally abolished the lymphocytosis-promoting activity, but exerted no effects on the epinephrine-hyperglycemia inhibitory activity, of the toxin.	Lysine	60-66	Cd47 molecule	Rattus norvegicus	83-86
6253494-9	1980	The data presented herein suggest that the interaction between RNase A and the inhibitor involves the positively charged epsilon-NH2 group of Lys-41 of RNase A.	Lysine	142-145	ribonuclease A family member 1, pancreatic	Homo sapiens	63-70
6253494-9	1980	The data presented herein suggest that the interaction between RNase A and the inhibitor involves the positively charged epsilon-NH2 group of Lys-41 of RNase A.	Lysine	142-145	ribonuclease A family member 1, pancreatic	Homo sapiens	152-159
6541059-5	1984	In contrast, the subunit assembly of IAP was maintained after exhaustive acetamidination of its lysine residues.	Lysine	96-102	Cd47 molecule	Rattus norvegicus	37-40
2933845-5	1985	In the presence of 1 mM tranexamic acid, the conversion of both Glu-plg I and II to their Lys-forms by plasmin was accelerated and completed in 30 min incubation.	Lysine	90-93	plasminogen	Homo sapiens	103-110
6541059-6	1984	The ADP-ribosyltransferase (or NAD-glycohydrolase) activity of the A-promoter (the biggest subunit) of IAP, which is responsible for the principal action of the toxin, enhancing insulin secretory responses and thereby inhibiting epinephrine hyperglycemia, was not affected by acetamindination of lysine residues.	Lysine	296-302	Cd47 molecule	Rattus norvegicus	103-106
2933845-8	1985	Another observation was that tranexamic acid protected the degradation of plasminogen by plasmin, indicating the involvement of the lysine binding sites (LBS) of plasmin in the proteolytic attack against plg.	Lysine	132-138	plasminogen	Homo sapiens	74-81
2862917-1	1985	Kinetic studies of pig kidney dipeptidyl peptidase IV (dipeptidyl-peptide hydrolase, EC 3.4.14.5) were carried out using substrates possessing a side-chain of different length at the P2 position (or amino-terminal position in this case) such as Lys-, Arg-, Phe-, Met-, Ser-, His-, Glu- and Gly-Pro-pNA.	Lysine	245-248	dipeptidyl peptidase 4	Sus scrofa	30-53
6204974-0	1984	Surface accessibility of 13C-labeled lysine residues in membrane-bound myelin basic protein.	Lysine	37-43	myelin basic protein	Homo sapiens	71-91
6377304-5	1984	In both elongation factor Tu complexes, kirromycin itself was found cross-linked to lysine-357.	Lysine	84-90	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	8-28
6769804-1	1980	Effects of dietary essential amino acid (leucine, isoleucine, valine, or lysine) limitations upon the native levels of serum immunoglobulin G (IgG), IgM, and IgA, as well as transferrin, the third component of complement (C3), and albumin were determined in CF1 mice by the radial immunodiffusion technique.	Lysine	73-79	immunoglobulin heavy variable V1-62	Mus musculus	125-141
6769804-1	1980	Effects of dietary essential amino acid (leucine, isoleucine, valine, or lysine) limitations upon the native levels of serum immunoglobulin G (IgG), IgM, and IgA, as well as transferrin, the third component of complement (C3), and albumin were determined in CF1 mice by the radial immunodiffusion technique.	Lysine	73-79	immunoglobulin heavy variable V1-62	Mus musculus	143-146
7383973-5	1980	A decrease in lysine in rat ceruloplasmin compared with human ceruloplasmin could account for its reduced anodal mobility.	Lysine	14-20	ceruloplasmin	Rattus norvegicus	28-41
3160389-0	1985	Photoaffinity labeling of functionally different lysine-binding sites in human plasminogen and plasmin.	Lysine	49-55	plasminogen	Homo sapiens	79-86
518546-10	1979	A higher proportion of hydroxylysinonorleucine in the reduced beta 12-chain probably reflects differences in extent of hydroxylation of specific lysine residues of the alpha 1 I- and alpha 2-chains.	Lysine	145-151	alpha-1-inhibitor III	Rattus norvegicus	168-177
6425075-5	1984	Unlike rat liver enzyme, brain ornithine aminotransferase was able to catalyze the reaction between L-lysine and 2-oxoglutarate.	Lysine	100-108	ornithine aminotransferase	Rattus norvegicus	31-57
3160389-6	1985	epsilon-Aminocaproic acid blocks incorporation of photoaffinity label into both plasminogen and plasmin, indicating that the labeling is specific to the lysine-binding sites.	Lysine	153-159	plasminogen	Homo sapiens	80-87
3160389-8	1985	These results indicate that the specific lysine-binding site blocked in plasmin acts in concert with the active-site in binding and using fibrin as a substrate.	Lysine	41-47	plasminogen	Homo sapiens	72-79
157166-0	1979	On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen.	Lysine	40-46	plasminogen	Homo sapiens	64-71
3160389-10	1985	The different lysine-binding sites labeled in plasminogen may regulate the conformation of the molecule as evidence by an enhanced rate of activation to plasmin.	Lysine	14-20	plasminogen	Homo sapiens	46-53
157166-1	1979	Plasminogen and plasminogen derivatives which contain lysine-binding sites were found to decrease the reaction rate between plasmin and alpha2-antiplasmin by competing with plasmin for the complementary site(s) in alpha2-antiplasmin.	Lysine	54-60	plasminogen	Homo sapiens	16-23
157166-1	1979	Plasminogen and plasminogen derivatives which contain lysine-binding sites were found to decrease the reaction rate between plasmin and alpha2-antiplasmin by competing with plasmin for the complementary site(s) in alpha2-antiplasmin.	Lysine	54-60	plasminogen	Homo sapiens	124-131
6326126-5	1984	Spt2 and spt3 mutations, known to suppress Ty insertions and their solo delta derivatives at HIS4, can also suppress at least one of the Ty insertions (Ty61) at LYS2 and can also suppress the Lys- phenotype of a solo delta derivative of another Ty insertion (Ty128) at LYS2.	Lysine	192-195	Spt2p	Saccharomyces cerevisiae S288C	0-4
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Lysine	36-39	myelin basic protein	Homo sapiens	58-78
6496220-3	1984	The effects of pH, time, caffeic acid level and the presence or not of tyrosinase on the decrease of FDNB-reactive lysine are described.	Lysine	115-121	tyrosinase	Rattus norvegicus	71-81
157166-3	1979	The lysine-binding site(s) which is situated in triple-loops 1--3 in the plasmin A-chain is mainly responsible for the interaction with alpha2-antiplasmin.	Lysine	4-10	plasminogen	Homo sapiens	73-80
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	plasminogen	Homo sapiens	126-133
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	plasminogen	Homo sapiens	126-133
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Lysine	36-39	myelin basic protein	Homo sapiens	80-83
665080-2	1978	The lupin cotyledons contain two cytoplasm-specific lysine tRNAs, one chloroplast-specific, one mitochondria-specific species, and three species common to all the cell compartments investigated; the lysine tRNAs were separated by reversed-phase chromatography (RPC-5).	Lysine	52-58	5'-nucleotidase, cytosolic IIIA	Homo sapiens	4-9
6317754-7	1983	Lyt-2 could not be stained with any fixative, but was well preserved in frozen material post-fixed with periodate-lysine based fixatives.	Lysine	114-120	CD8 antigen, alpha chain	Mus musculus	0-5
665080-2	1978	The lupin cotyledons contain two cytoplasm-specific lysine tRNAs, one chloroplast-specific, one mitochondria-specific species, and three species common to all the cell compartments investigated; the lysine tRNAs were separated by reversed-phase chromatography (RPC-5).	Lysine	199-205	5'-nucleotidase, cytosolic IIIA	Homo sapiens	4-9
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Lysine	36-39	myelin basic protein	Homo sapiens	142-145
3925986-1	1985	Biotinidase catalyzes the hydrolysis of N epsilon-biotinyllysine (biocytin) to form biotin and free lysine.	Lysine	58-64	biotinidase	Homo sapiens	0-11
329889-8	1977	Acetylation of the repressor protein with N-acetylimidazole modified lysines and tyrosines with complete loss of operator binding activity and retention of 75-80% of inducer binding activity.	Lysine	69-76	repressor	Escherichia coli	19-28
6236789-2	1983	Plasmin(ogen) contains structures, called lysine-binding sites, which mediate its interaction with fibrin and with alpha 2-antiplasmin.	Lysine	42-48	plasminogen	Homo sapiens	0-7
6236789-6	1983	The formed plasmin, which remains transiently complexed to fibrin, both by its lysine-binding site(s) and active center, is only slowly inactivated by alpha 2-antiplasmin, while plasmin which is released from digested fibrin is rapidly and irreversibly neutralized.	Lysine	79-85	plasminogen	Homo sapiens	11-18
6219709-0	1983	The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen.	Lysine	16-22	plasminogen	Homo sapiens	46-53
3156054-1	1985	Experiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmin-catalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen.	Lysine	171-177	plasminogen	Homo sapiens	61-68
6219709-1	1983	The importance of the lysine binding sites of human plasmin for its ability to digest human fibrinogen has been assessed by analyzing the nature and rate of the products formed in the presence of epsilon-aminocaproic acid.	Lysine	22-28	plasminogen	Homo sapiens	52-59
6853636-2	1983	Evidence was obtained that in spite of the identical specificities and similar activities of alpha- and beta-trypsin, the cleavage of the Lys-Ser bond induces conformational changes in the neighbourhood of the active site.	Lysine	138-141	serine protease 1	Homo sapiens	93-116
868789-6	1977	These were the dietary patterns of the lowest income groups in the rural Northeast and the City of Sao Paulo which were somewhat limiting in methionine and lysine, respectively.	Lysine	156-162	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	99-102
3156054-1	1985	Experiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmin-catalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen.	Lysine	171-177	plasminogen	Homo sapiens	108-115
139407-0	1977	Purification and some properties of the Glu- and Lys-human plasmin heavy chains.	Lysine	49-52	plasminogen	Homo sapiens	59-66
3933549-8	1985	When casein was reacted with caffeic acid at pH 7 in the presence of monophenol monooxygenase (tyrosinase; EC 1.14.18.1), no chemical loss of tryptophan occurred, although fluorodinitrobenzene-reactive lysine fell by 23%.	Lysine	202-208	tyrosinase	Rattus norvegicus	95-105
868388-1	1977	Ultraviolet light (PRK-2) induces the formation of various amino acids (lysine, asparaginic, as well as traces of some other acids) in mannose, glucose and arabinose solutions containing various nitrates.	Lysine	72-78	protein kinase N2	Homo sapiens	19-24
4015823-6	1985	The molecular abnormality of the inactive ALDH2(2) is found to be the substitution of Glu at the 14th position from the COOH-terminal of the protein by Lys which resulted from G----A transition in the gene.	Lysine	152-155	aldehyde dehydrogenase 2 family member	Homo sapiens	42-47
65186-6	1977	The N-terminal amino acids were found to be Lys, Arg and Leu respectively for the three forms of post gamma-globulin.	Lysine	44-47	cystatin C	Homo sapiens	97-116
137901-8	1977	A second peptide is then cleaved from the NH2-terminal end of the heavy chain of plasmin producing a proteolytically modified heavy chain (Mr =60.000 with NH2-terminal lysine).	Lysine	168-174	plasminogen	Homo sapiens	81-88
6130090-4	1983	The extent of maximum stimulation of the EF-Tu GTPase in the presence of ribosomes varies moderately depending on the aa-tRNA species; a clear dependence on the nature of the aminoacyl side chain is observed in the effects of their respective C-C-A-aa fragments tested (C-C-A-Arg, C-C-A-Val, C-C-A-Phe, C-C-A-Met, C-C-A-Lys).	Lysine	320-323	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	41-46
6219471-4	1982	In this second group, the behaviour of the plasmins resembles that of 442-Val-plasmin (miniplasmin), which is known to show a low inactivation rate with alpha 2-antiplasmin due to the absence of lysine-binding sites in the plasmin molecule.	Lysine	195-201	plasminogen	Homo sapiens	78-85
137749-1	1977	A method for determining initial velocities of the urokinase (EC 3.4.99.26) catalysed converstion of NH2-terminal lysine plasminogen to plasmin (EC 3.4.21.7) is presented.	Lysine	114-120	plasminogen	Homo sapiens	121-128
2422420-3	1985	alpha 2-Macroglobulin-plasmin complexes were purified from urokinase-activated plasma by affinity chromatography on lysine-Sepharose and gel filtration on Ultrogel AcA 22.	Lysine	116-122	plasminogen	Homo sapiens	22-29
134997-1	1976	A functionally active human plasmin light (B) chain derivative, stabilized by the streptomyces plasmin inhibitor leupeptin, was isolated from a partially reduced and alkylated enzyme preparation by an affinity chromatography method with a L-lysine-substituted Sepharose column.	Lysine	239-247	plasminogen	Homo sapiens	28-35
6217905-0	1982	[Hemoglobin Beijing [alpha 16 (A14) Lys leads to Asn]: a new fast moving hemoglobin variant].	Lysine	36-39	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	31-34
6240993-4	1984	It is assumed that the interaction of plasminogen and plasmin with fibrin is provided for not only by the lysine binding but also by the benzamidine binding sites of the plasminogen molecule.	Lysine	106-112	plasminogen	Homo sapiens	38-45
6283552-1	1982	The amino acid sequence of human gamma-trace, a basic microprotein without known function, was determined by automated Edman degradations of the carboxymethylated polypeptide chain and of fragments obtained by cyanogen bromide treatment and tryptic digestion after blocking of lysine residues.	Lysine	277-283	cystatin C	Homo sapiens	33-44
986943-11	1976	The beta-trypsin-catalysed hydrolysis of the L-lysine substrates was investigated over a range of temperature (15--35 degrees C).	Lysine	45-53	serine protease 1	Bos taurus	4-16
6238095-7	1984	Thus, lysine residues are important determinants of the binding capacity of H for cell-bound C3b, whereas the carbohydrate portion of the molecule is not required for the regulatory function of the protein on the amplification C3 convertase.	Lysine	6-12	endogenous retrovirus group K member 3	Homo sapiens	93-96
71038-2	1976	Insulin stimulates the incorporation of lysine from the 29th day and of glycine from the 31st day of gestation onwards.	Lysine	40-46	insulin	Oryctolagus cuniculus	0-7
6273432-1	1982	Amidination of the available lysine residues of the complex between RNase A and human placental RNase inhibitor has been performed with methyl acetimidate; the conditions of the derivatization preserve the complex functionally intact.	Lysine	29-35	ribonuclease A family member 1, pancreatic	Homo sapiens	68-75
6273432-4	1982	In the presence of poly(A), lysine residues 41 and 61 of RNase A were fully protected from amidination, while lysine residues 7, 31, 37, 91, and 104 were only partially protected; the enzyme retained full activity.	Lysine	28-34	ribonuclease A family member 1, pancreatic	Homo sapiens	57-64
6273432-5	1982	The results permit identification of lysine residues located in the binding domain of RNase A for the inhibitor.	Lysine	37-43	ribonuclease A family member 1, pancreatic	Homo sapiens	86-93
6566612-5	1984	The biosynthetic activities of aorta explants of rabbits immunized with kappa 1-elastin maintained in organ culture conditions were considerably reduced, as shown by the decrease of incorporation of [14C]lysine and [14C]glucosamine in aorta macromolecules.	Lysine	204-210	elastin	Oryctolagus cuniculus	80-87
6459779-3	1981	This binding is decreased by alpha(2)-plasmin inhibitor and tranexamic acid, and is, in the latter case, related to saturation of a strong lysine-binding site.	Lysine	139-145	plasminogen	Homo sapiens	38-45
6459779-6	1981	Active-site-inhibited Lys-plasmin and Lys-plasminogen (Glu-plasminogen lacking the N-terminal residues Glu(1)-Lys(76), Glu(1)-Arg(67) or Glu(1)-Lys(77))display binding to fibrin similar to that of active-site inhibited Glu-plasmin.	Lysine	22-25	plasminogen	Homo sapiens	26-33
6459779-6	1981	Active-site-inhibited Lys-plasmin and Lys-plasminogen (Glu-plasminogen lacking the N-terminal residues Glu(1)-Lys(76), Glu(1)-Arg(67) or Glu(1)-Lys(77))display binding to fibrin similar to that of active-site inhibited Glu-plasmin.	Lysine	38-41	plasminogen	Homo sapiens	42-49
1237295-3	1975	Evidence has been obtained that the penicillin-reactive sites on the insulin molecule are the alpha-amino group at the N-terminus of the A chain and the epsilon-amino group of the lysine residue; whereas a site of reaction with lysozyme appears to be the epsilon-amino group of lysine-116.	Lysine	180-186	insulin	Sus scrofa	69-76
1237295-3	1975	Evidence has been obtained that the penicillin-reactive sites on the insulin molecule are the alpha-amino group at the N-terminus of the A chain and the epsilon-amino group of the lysine residue; whereas a site of reaction with lysozyme appears to be the epsilon-amino group of lysine-116.	Lysine	278-284	insulin	Sus scrofa	69-76
238843-0	1975	Proton-magnetic-resonance studies of the lysine residues of ribonuclease A.	Lysine	41-47	ribonuclease A family member 1, pancreatic	Homo sapiens	60-74
6792989-0	1981	Multifunctionality of lipoamide dehydrogenase: lysine residue and cationic environment.	Lysine	47-53	dihydrolipoamide dehydrogenase	Homo sapiens	22-45
6232970-6	1984	Structural changes induced by crosslinking of fibrin alpha-chain may reduce either the affinity or the number of available complementary sites to lysine binding sites of plasmin(ogen), thereby decreasing the binding of plasmin(ogen) to fibrin.	Lysine	146-152	plasminogen	Homo sapiens	170-177
6452880-0	1981	Plasmin: photoaffinity labeling of a lysine-binding site which regulated clot lysis.	Lysine	37-43	plasminogen	Homo sapiens	0-7
1122293-8	1975	Of the basic amino acids platelet factor 4 (molecular weight 27 100) contained 5.97% arginine, 3.18% histidine, and 12.31% lysine compared to protamine sulphate with 64.2% arginine, 0.6% lysine and no histidine.	Lysine	123-129	platelet factor 4	Homo sapiens	25-42
6232970-6	1984	Structural changes induced by crosslinking of fibrin alpha-chain may reduce either the affinity or the number of available complementary sites to lysine binding sites of plasmin(ogen), thereby decreasing the binding of plasmin(ogen) to fibrin.	Lysine	146-152	plasminogen	Homo sapiens	219-226
6235238-6	1984	The results indicate a two-site interaction of plasmin with the immobilized ligand, i.e., at the lysine-binding sites and the catalytic site.	Lysine	97-103	plasminogen	Homo sapiens	47-54
1141204-15	1975	Intracellular concentrations of seven amino acids, including threonine, serine, proline, glycine, alanine, lysine, and arginine, were increased significantly in livers perfused with medium containing growth hormone...	Lysine	107-113	gonadotropin releasing hormone receptor	Rattus norvegicus	200-214
6450619-3	1980	ATP protected specifically against fluorescein isothiocyanate inhibition, indicating that fluorescein isothiocyanate may react at the nucleotide binding site of the ATPase (probably with a reactive lysine residue).	Lysine	198-204	dynein axonemal heavy chain 8	Homo sapiens	165-171
6326126-5	1984	Spt2 and spt3 mutations, known to suppress Ty insertions and their solo delta derivatives at HIS4, can also suppress at least one of the Ty insertions (Ty61) at LYS2 and can also suppress the Lys- phenotype of a solo delta derivative of another Ty insertion (Ty128) at LYS2.	Lysine	192-195	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	269-273
6329161-2	1984	Dissociation constants have been determined for complexes of adrenodoxin, hepatoredoxin , cytochrome b5 heme-containing tryptic fragment and myoglobin with cytochrome c preparations immobilized via lysine residues (cytochrome c-Sepharose I) or additional imidazole groups (cytochrome c-Sepharose II).	Lysine	198-204	cytochrome b	Equus caballus	90-102
6251869-2	1980	Cytochrome c derivatives, arylazido-labeled at lysine 13 or lysine 22, were prepared and their properties as electron acceptors from the bc1 complex were measured.	Lysine	47-53	LOC104968582	Bos taurus	0-12
6251869-2	1980	Cytochrome c derivatives, arylazido-labeled at lysine 13 or lysine 22, were prepared and their properties as electron acceptors from the bc1 complex were measured.	Lysine	60-66	LOC104968582	Bos taurus	0-12
4429670-0	1974	Hemoglobin St. Claude or alpha2-127(H10)Lys leads to Thr-beta2.	Lysine	40-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-62
6582480-4	1984	Separation of their digests by high-performance reverse-phase chromatography and by two-dimensional paper chromatography and electrophoresis revealed that ALDH2 contained a peptide sequence of -Glu-Leu-Gly-Glu-Ala-Gly-Leu-Gln-Ala-Asn-Val-Gln-Val-Lys- and that the glutamine adjacent to lysine was substituted by lysine in CRM.	Lysine	246-249	aldehyde dehydrogenase 2 family member	Homo sapiens	155-160
5126933-0	1971	Complexes of phosvitin with poly-L-lysine and protamine.	Lysine	28-41	casein kinase 2 beta	Homo sapiens	13-22
6773954-9	1980	A rapid chromatographic procedure for the separation of methylated lysines and arginines was developed and used to demonstrate that epsilon-trimethyllysine is the radioactive amino acid formed when calmodulin is methylated in vitro.	Lysine	67-74	calmodulin 1	Rattus norvegicus	198-208
6582480-4	1984	Separation of their digests by high-performance reverse-phase chromatography and by two-dimensional paper chromatography and electrophoresis revealed that ALDH2 contained a peptide sequence of -Glu-Leu-Gly-Glu-Ala-Gly-Leu-Gln-Ala-Asn-Val-Gln-Val-Lys- and that the glutamine adjacent to lysine was substituted by lysine in CRM.	Lysine	286-292	aldehyde dehydrogenase 2 family member	Homo sapiens	155-160
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Lysine	161-167	insulin	Oryctolagus cuniculus	24-31
6582480-4	1984	Separation of their digests by high-performance reverse-phase chromatography and by two-dimensional paper chromatography and electrophoresis revealed that ALDH2 contained a peptide sequence of -Glu-Leu-Gly-Glu-Ala-Gly-Leu-Gln-Ala-Asn-Val-Gln-Val-Lys- and that the glutamine adjacent to lysine was substituted by lysine in CRM.	Lysine	312-318	aldehyde dehydrogenase 2 family member	Homo sapiens	155-160
6447693-1	1980	Fluorogenic peptides, peptidyl-4-methylcoumaryl-7-amides (MCA), containing COOH-terminal lysine residues, were newly synthesized and tested as substrates for plasmin.	Lysine	89-95	plasminogen	Homo sapiens	158-165
6582480-6	1984	It is concluded that a point mutation in the human ALDH2 locus produced the glutamine leads to lysine substitution and enzyme inactivation.	Lysine	95-101	aldehyde dehydrogenase 2 family member	Homo sapiens	51-56
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Lysine	186-189	myelin basic protein	Homo sapiens	97-117
6997872-2	1980	Solid-phase synthesis of the substituted octapeptides B23-B30 bearing the trifluoracetyl group on lysine-B29, enzymatic coupling of the octapeptides to bis(tertiary-butyloxycarbonyl)desoctapeptide insulin by trypsin, and deprotection of the corresponding adducts in formic acid and piperidine resulted in two insulin derivatives, one with leucine at position B24 and the other with leucine at position B25.	Lysine	98-104	nucleophosmin 1	Homo sapiens	54-57
5663809-2	1968	This observation indicates that hydroxylation of these lysines by protocollagen hydroxylase has been effected to a very minor extent.	Lysine	55-62	prolyl 4-hydroxylase subunit beta	Homo sapiens	66-91
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Lysine	186-189	myelin basic protein	Homo sapiens	118-121
6194176-1	1983	From an examination of electroimmunoblots and peptide maps, a mouse monoclonal antibody to human myelin basic protein MBP was shown to react with the amino acid sequence Ala-Ser-Asp-Tyr-Lys-Ser which is located in the C-terminal half of MBP.	Lysine	186-189	myelin basic protein	Homo sapiens	237-240
33912962-6	2022	Functionally, PDZD8 is required for LE/lys positioning and neurite outgrowth, which is dependent on the lipid transfer activity of the SMP domain.	Lysine	39-42	PDZ domain containing 8	Homo sapiens	14-19
17248969-3	1979	Lys2 mutants were conveniently selected on media containing alpha-aminoadipate as a nitrogen source, lysine, and other supplements to furnish other possible auxotrophic requirements.	Lysine	101-107	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	0-4
17248969-4	1979	The lys2 mutations were obtained in a variety of laboratory strains containing other markers, including other lysine mutations.	Lysine	110-116	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	4-8
6347401-8	1983	The plasmin esterase inhibitors, epsilon-amino-n-caproic acid, tranexamic acid, and L-lysine, previously established to reverse the MMI response to MIF, FBP, and C3 activators were found to inhibit both Fc- and C3-dependent phagocytosis.	Lysine	84-92	macrophage migration inhibitory factor	Ovis aries	148-151
33400276-1	2021	RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub).	Lysine	170-176	ring finger protein 2	Homo sapiens	0-4
33400276-1	2021	RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub).	Lysine	170-176	ring finger protein 2	Homo sapiens	26-32
33400276-1	2021	RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub).	Lysine	170-176	ring finger protein 2	Homo sapiens	36-41
6307354-5	1983	We propose that the carbodiimide promoted the formation of amide cross-links between lysine amino groups surrounding the heme crevice of cytochrome c and complementary carboxyl groups on plastocyanin.	Lysine	85-91	LOC104968582	Bos taurus	137-149
33865992-10	2021	The Car group had a significantly higher post-prandial tissue concentration of lysine, compared to the (-) Control group.	Lysine	79-85	CXADR Ig-like cell adhesion molecule	Danio rerio	4-7
762166-4	1979	Enterokinase hydrolyzed lysine and arginine substrates and slowly reacted with the trypsin active site titrant 4-methylumbelliferyl-p-guanidinobenzoate.	Lysine	24-30	transmembrane serine protease 15	Bos taurus	0-12
154322-13	1978	In contrast with this, the inhibitory effects of l-lysine and 6-aminohexanoic acid on the inhibitor-plasmin reaction occur at concentrations much too low to affect the active site of plasmin.	Lysine	49-57	plasminogen	Homo sapiens	100-107
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Lysine	182-185	Mf(Alpha)2p	Saccharomyces cerevisiae S288C	0-10
154322-13	1978	In contrast with this, the inhibitory effects of l-lysine and 6-aminohexanoic acid on the inhibitor-plasmin reaction occur at concentrations much too low to affect the active site of plasmin.	Lysine	49-57	plasminogen	Homo sapiens	183-190
33827259-1	2021	OBJECTIVE: Smyd3 (SET and MYND domain-containing protein 3) is an H3K4 (histone H3 lysine 4) dimethyltransferase and trimethyltransferase that activates the transcription of oncogenes and cell cycle genes in human cancer cells.	Lysine	83-89	SET and MYND domain containing 3	Homo sapiens	11-16
33827259-1	2021	OBJECTIVE: Smyd3 (SET and MYND domain-containing protein 3) is an H3K4 (histone H3 lysine 4) dimethyltransferase and trimethyltransferase that activates the transcription of oncogenes and cell cycle genes in human cancer cells.	Lysine	83-89	SET and MYND domain containing 3	Homo sapiens	18-58
150862-1	1978	The effects of L-lysine, 6-aminohexanoic acid, and trans-4-aminomethylcy-clohexane-1-carboxylic acid on the catalytic activity of plasmin (EC 3.4.21.7) have been investigated.	Lysine	15-23	plasminogen	Homo sapiens	130-137
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Lysine	182-185	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	138-148
150862-7	1978	The experimental observations seem to be explained best by assuming that L-lysine and certain analogous compounds function as both allosteric modifiers and competitive inhibitors of plasmin.	Lysine	73-81	plasminogen	Homo sapiens	182-189
33857328-5	2021	Also, a new prophylactic and therapeutic measure against SARS-CoV-2 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein.	Lysine	191-198	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	151-156
6219709-4	1983	However, since both plasmin forms were inhibited equally well at all levels of epsilon-aminocaproic acid, these studies show that lysine binding sites other than those present on region K 1-4 of Lys77-plasmin are of primary importance to fibrinogenolysis by plasmin.	Lysine	130-136	plasminogen	Homo sapiens	20-27
33857328-5	2021	Also, a new prophylactic and therapeutic measure against SARS-CoV-2 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein.	Lysine	191-198	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	206-211
149657-2	1978	The low-Mr plasmin, which is obtained by limited elastase digestion, is composed of an intact B chain and a small A chain lacking the lysine-binding sites.	Lysine	134-140	plasminogen	Homo sapiens	11-18
6299737-6	1983	By using an arylazido derivative of cytochrome c, having the photoactive group bound to lysine 13, upon illumination a cross-link with the described preparation of cytochrome c1 was obtained.	Lysine	88-94	LOC104968582	Bos taurus	36-48
149657-8	1978	The findings further indicate that the lysine-binding site(s) of plasmin are of great importance for the rate of its reaction with antiplasmin.	Lysine	39-45	plasminogen	Homo sapiens	65-72
34020664-0	2021	Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain.	Lysine	94-100	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
209477-10	1978	These results suggest that secretion of ACTH at least partially mediates the stress-induced changes of [3H] lysine incorporation into brain and liver proteins, but that it is probably not the only factor involved.	Lysine	108-114	pro-opiomelanocortin-alpha	Mus musculus	40-44
6220979-1	1982	To establish a method for radiochemical quality control of [99mTc]plasmin based on the known affinity of plasmin for lysine residues, human [113Sn]plasmin and [99mTc]plasmin formed by different methods were analyzed in an affinityradiochromatographic system of lysine coupled to CNBr-activated sepharosis.	Lysine	117-123	plasminogen	Homo sapiens	105-112
562749-6	1977	Ethyl phosphoglycollate irreversibly inhibits rabbit muscle fructose-1,6-bisphosphate aldolase in the presence of sodium borohydride, presumably by forming a stable secondary amine through the active-site lysine reside.	Lysine	205-211	fructose-bisphosphate aldolase B	Oryctolagus cuniculus	60-94
34014094-6	2021	LC-MS/MS analysis of trypsin digests of Pol beta treated with 14 identified two lysines within the polymerase binding site that are covalently modified, one of which was previously determined to play a role in DNA binding.	Lysine	80-87	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	40-48
6220979-1	1982	To establish a method for radiochemical quality control of [99mTc]plasmin based on the known affinity of plasmin for lysine residues, human [113Sn]plasmin and [99mTc]plasmin formed by different methods were analyzed in an affinityradiochromatographic system of lysine coupled to CNBr-activated sepharosis.	Lysine	117-123	plasminogen	Homo sapiens	105-112
34013595-1	2022	The epigenetic enzyme G9a is a histone methyltransferase that dimethylates lysine 9 on histone H3 (H3K9me2), and in the adult nucleus accumbens (NAc), G9a regulates multiple behaviors associated with substance use disorder.	Lysine	75-81	euchromatic histone lysine N-methyltransferase 2	Mus musculus	22-25
6220979-1	1982	To establish a method for radiochemical quality control of [99mTc]plasmin based on the known affinity of plasmin for lysine residues, human [113Sn]plasmin and [99mTc]plasmin formed by different methods were analyzed in an affinityradiochromatographic system of lysine coupled to CNBr-activated sepharosis.	Lysine	117-123	plasminogen	Homo sapiens	105-112
6220979-2	1982	From the observed immobilizations of the radioactivity when the plasmin was bound to the lysine-sepharosis, radiochemical purities of radiolabelled plasmin could be calculated.	Lysine	89-95	plasminogen	Homo sapiens	64-71
33999467-8	2021	The clearest case of where methyl-induced polarization plays a dominant role in regulating biological function is that of the PHD1-PHD2 domain that recognizes lysine methylated-states on histones.	Lysine	159-165	egl-9 family hypoxia inducible factor 2	Homo sapiens	126-130
6220979-2	1982	From the observed immobilizations of the radioactivity when the plasmin was bound to the lysine-sepharosis, radiochemical purities of radiolabelled plasmin could be calculated.	Lysine	89-95	plasminogen	Homo sapiens	148-155
6216916-5	1982	Lysine inhibited fibrinogenolysis by both Lys77-plasmin and Val442-plasmin.	Lysine	0-6	plasminogen	Homo sapiens	48-55
921761-3	1977	We describe the use of benzyloxycarbonylmethionine and ethoxycarbonylmethionine for the selective protection of the amino groups of glycine-A1 and lysine-B29 of pig insulin.	Lysine	147-153	insulin	Sus scrofa	165-172
33716308-3	2021	The structures of the SARS-CoV-2 and SARS-CoV PLpro in complex with interferon-stimulated gene 15 (ISG15) and lysine 48 (K48)-linked diubiquitin were utilised.	Lysine	110-116	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	46-51
6216916-5	1982	Lysine inhibited fibrinogenolysis by both Lys77-plasmin and Val442-plasmin.	Lysine	0-6	plasminogen	Homo sapiens	67-74
6216916-8	1982	These results indicate that the lysine binding regions present in Lys77-plasmin but absent in Val442-plasmin do not determine the rate, reaction products, or lysine inhibition of fibrinolysis and fibrinogenolysis by plasmin.	Lysine	32-38	plasminogen	Homo sapiens	72-79
6812621-9	1982	Those elastin molecules which do become incorporated into the extracellular matrix in the presence of ascorbate contain a slightly elevated content of hydroxyproline and lysine and, most importantly, are turned over more rapidly.	Lysine	170-176	elastin	Oryctolagus cuniculus	6-13
33583954-2	2021	The results of molecular docking positioned four molecules at the interaction site Tyr-491(Spike)-Glu-37(ACE2) and one at the site Gly-488(Spike)-Lys-353(ACE2).	Lysine	146-149	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	139-144
33583954-2	2021	The results of molecular docking positioned four molecules at the interaction site Tyr-491(Spike)-Glu-37(ACE2) and one at the site Gly-488(Spike)-Lys-353(ACE2).	Lysine	146-149	angiotensin converting enzyme 2	Homo sapiens	154-158
20736-0	1977	Evidence of decarboxylation of lysine by mammalian ornithine decarboxylase.	Lysine	31-37	ornithine decarboxylase 1	Homo sapiens	51-74
24186298-5	1982	One of them was identified as LYS7, the gene previously known as the structure gene for homocitric dehydrase, in terms of co-segregation and co-reversion of chromium sensitivity and lysine dependency which did not complement an authentic lys7 mutation.	Lysine	182-188	copper chaperone CCS1	Saccharomyces cerevisiae S288C	30-34
871045-3	1977	Mathematical computer-assisted programs developed to aid in determining clusters of amino acid variables suggested that excretion of glycine, leucine, proline, and glutamic acid in men and concentrations of valine, serine, aspartic acid, phenylalanine, and lysine in women vary according to the invasiveness of the disease.	Lysine	257-263	activation induced cytidine deaminase	Homo sapiens	53-56
33986248-4	2021	PiHL antagonized chemosensitivity through binding with EZH2, repressing location of EZH2 to HMGA2 promoter, and downregulating methylation of histone H3 lysine 27 (H3K27me3) level in HMGA2 promoter, thus activating HMGA2 expression.	Lysine	153-159	prostate cancer associated transcript 1	Homo sapiens	0-4
837244-1	1977	Sheep beta-lipotropin (beta-LPH) (sequence 1-91) was selectively cleaved with trypsin after blocking the epsilon-amino groups of lysine with citraconic anhydride.	Lysine	129-135	pro-opiomelanocortin-alpha	Mus musculus	23-31
6802176-4	1982	Studies were made on the lysine content of casein reacted with caffeic acid oxidized aerobically under alkaline conditions of enzymically with tyrosinase (EC 1.	Lysine	25-31	tyrosinase	Rattus norvegicus	143-153
132442-4	1976	However, the final stable plasmin, Lys-Pmb, which is obtained contains a heavy chain (Lys-Hb) which arises by plasminolysis of a small peptide from the NH2 terminus of Glu-Ha.	Lysine	35-38	plasminogen	Homo sapiens	26-33
33400854-0	2021	Discovery of an allosteric ligand binding site in SMYD3 lysine methyltransferase.	Lysine	56-62	SET and MYND domain containing 3	Homo sapiens	50-55
33400854-1	2021	SMYD3 is a multifunctional epigenetic enzyme with lysine methyl transferase activity and various interaction partners.	Lysine	50-56	SET and MYND domain containing 3	Homo sapiens	0-5
6802176-10	1982	In presence of the enzyme mushroom tyrosinase, maximum reduction of reactive lysine occurred at pH 7 and was dependent on the reaction time and on the concentration of caffeic acid.	Lysine	77-83	tyrosinase	Rattus norvegicus	35-45
33852305-5	2021	DNA-H2A formed the classic "beads-on-string" conformation on poly-l-lysine (PLL) and lipid substrates.	Lysine	61-74	H2A clustered histone 18	Homo sapiens	4-7
6462134-7	1981	Heparin must bind to plasmin to accelerate the plasmin-antithrombin III reaction, since the modification of four to five lysine residues of the enzyme inhibits the rate-enhancement effect of heparin and the dissociation of heparin-plasmin complex decreases the inactivation rate of plasmin.	Lysine	121-127	plasminogen	Homo sapiens	21-28
180015-3	1976	These four forms of ACTH can be detected by radioimmunoassay of cell extracts or by immunoprecipitation of cell extracts following incubation of cultures in [3H] tryptophan, [3H] lysine, or [3H] tyrosine.	Lysine	179-185	pro-opiomelanocortin-alpha	Mus musculus	20-24
6462134-7	1981	Heparin must bind to plasmin to accelerate the plasmin-antithrombin III reaction, since the modification of four to five lysine residues of the enzyme inhibits the rate-enhancement effect of heparin and the dissociation of heparin-plasmin complex decreases the inactivation rate of plasmin.	Lysine	121-127	plasminogen	Homo sapiens	47-54
33894670-2	2021	In particular tri-methylation of H3 lysine 27 (H3K27me3), which is catalyzed by PHD finger protein 19 (PHF19), a subunit of the Polycomb Repressive Complex 2 (PRC2), has recently shown to be a crucial mediator of MM tumorigenicity.	Lysine	36-42	PHD finger protein 19	Homo sapiens	80-101
128454-1	1975	A method is described by which the heavy chain of human plasmin, obtained by partial reduction of urokinase-activated plasminogen with 2-mercaptoethanol, is adsorbed on lysine coupled to polyacrylamide.	Lysine	169-175	plasminogen	Homo sapiens	56-63
6462134-7	1981	Heparin must bind to plasmin to accelerate the plasmin-antithrombin III reaction, since the modification of four to five lysine residues of the enzyme inhibits the rate-enhancement effect of heparin and the dissociation of heparin-plasmin complex decreases the inactivation rate of plasmin.	Lysine	121-127	plasminogen	Homo sapiens	47-54
33894670-2	2021	In particular tri-methylation of H3 lysine 27 (H3K27me3), which is catalyzed by PHD finger protein 19 (PHF19), a subunit of the Polycomb Repressive Complex 2 (PRC2), has recently shown to be a crucial mediator of MM tumorigenicity.	Lysine	36-42	PHD finger protein 19	Homo sapiens	103-108
6462134-7	1981	Heparin must bind to plasmin to accelerate the plasmin-antithrombin III reaction, since the modification of four to five lysine residues of the enzyme inhibits the rate-enhancement effect of heparin and the dissociation of heparin-plasmin complex decreases the inactivation rate of plasmin.	Lysine	121-127	plasminogen	Homo sapiens	47-54
33400925-0	2021	Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.	Lysine	37-43	E1A binding protein p300	Homo sapiens	71-75
6457628-0	1981	Role of lysine binding regions in the kinetic properties of human plasmin.	Lysine	8-14	plasminogen	Homo sapiens	66-73
33400925-1	2021	The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and KAT3B) maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains.	Lysine	131-137	E1A binding protein p300	Homo sapiens	52-56
33400925-1	2021	The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and KAT3B) maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains.	Lysine	131-137	E1A binding protein p300	Homo sapiens	82-87
1150667-2	1975	The cleavage of the preactivation peptide from the NH2 terminus of native plasminogen (NH2-terminal glutamic acid) is clearly catalyzed by urokinase and is the rate-limiting first step in activation (Stage 1); this reaction is 20-fold slower than the conversion of the intermediate plasminogen (NH2-terminal lysine) to plasmin (Stage 2).	Lysine	308-314	plasminogen	Homo sapiens	74-81
1150667-8	1975	Plasmin also cleaves the preactivation peptide from native plasminogen and this reaction rate is enhanced by the same concentrations of lysine and epsilon-aminocaproic acid.	Lysine	136-142	plasminogen	Homo sapiens	0-7
7309353-3	1981	With free amino acids, the osmium(VIII) reagents are most reactive with Met, Cys, His, Thr, Ser, Trp, Lys, and Pro; the osmium(VI) reagent only reacts significantly with His, Met, Cys, Thr, and Ser.	Lysine	102-105	cytochrome c oxidase subunit 8A	Homo sapiens	34-38
125463-6	1975	in the binding studies with the highly purified plasminogen and TLCK-plasmin preparations which were obtained by affinity chromatography on lysine-substituted Sepharose, the molar binding ratio was shown to be 1.5-1.6 moles tranexamic acid per one mole protein.	Lysine	140-146	plasminogen	Homo sapiens	48-55
33858315-14	2022	Binding mode analysis for CDK2 inhibition studies indicate that hydrogen bonding interaction with Lys 33 and Leu83 are important for the activity.	Lysine	98-101	cyclin dependent kinase 2	Homo sapiens	26-30
33443933-1	2021	Tranexamic acid (TXA) is a lysine analogue that inhibits plasmin generation and has been used for decades as an antifibrinolytic agent to reduce bleeding.	Lysine	27-33	plasminogen	Homo sapiens	57-64
7005220-1	1981	Lysine 372 of N-ethylmaleimide actin was specifically (60%) labeled by 7-chloro-4-nitrobenzeno-2-oxa-1,3-diazole chloride (NBD-Cl), which also reacted with lysines on cyanogen bromide fragment 17 (20%) and other undetermined residues (20%).	Lysine	0-6	OXA1L mitochondrial inner membrane protein	Homo sapiens	97-102
33279621-5	2021	In contrast, mutations at lysines 80 and 87 of Rae-1 abrogated this acetylation and thereby desensitized tumor cells to NKG2D-dependent immune surveillance.	Lysine	26-33	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	120-125
1219371-1	1975	The physico-chemical properties have been studied of RNase A selectively modified at the E-NH2-group of Lys-7 and Lys-41 with pyridoxal-P.	Lysine	104-107	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
1219371-1	1975	The physico-chemical properties have been studied of RNase A selectively modified at the E-NH2-group of Lys-7 and Lys-41 with pyridoxal-P.	Lysine	114-117	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
1219371-2	1975	Modification did not affect conformational stability of the protein globule, thus all changes in the molecule of the modified RNase A were localised around the alkylated Lys residue.	Lysine	170-173	ribonuclease A family member 1, pancreatic	Homo sapiens	126-133
33279621-7	2021	Our results suggest that the acetylation of Rae-1 protein at lysines 80 and 87 by GCN5 and PCAF protects Rae-1 from shedding so as to activate NKG2D-dependent immune surveillance.	Lysine	61-68	killer cell lectin like receptor K1	Homo sapiens	143-148
7005220-1	1981	Lysine 372 of N-ethylmaleimide actin was specifically (60%) labeled by 7-chloro-4-nitrobenzeno-2-oxa-1,3-diazole chloride (NBD-Cl), which also reacted with lysines on cyanogen bromide fragment 17 (20%) and other undetermined residues (20%).	Lysine	156-163	OXA1L mitochondrial inner membrane protein	Homo sapiens	97-102
6449829-3	1980	This substance, designated "plasmin", was separated from plasmin and kallikrein in a three-step procedure using columns of lysine-Sepharose, DEAE-Sephadex A-50, and arginine-Sepharose.	Lysine	123-129	plasminogen	Homo sapiens	28-35
6105888-1	1980	Divalent copper and copper complexes of tyrosine, histidine and lysine inhibited at low concentrations the stearoyl-CoA desaturation reaction in both chicken liver microsomes and in a purified system consisting of chicken liver delta 9 terminal desaturase, cytochrome b5, ascorbate and liposome.	Lysine	64-70	cytochrome b5 type A	Gallus gallus	257-270
33469840-1	2021	BACKGROUND: Bromodomain and extra-terminal (BET) proteins are epigenetic readers that bind to acetylated lysines of histones and regulate gene transcription.	Lysine	105-112	delta/notch like EGF repeat containing	Homo sapiens	44-47
33742125-2	2021	NSD2, a histone methyltransferase catalyzing di-methylation of histone H3 at lysine 36, has been proved a critical molecule in proliferation, metastasis, and tumorigenesis.	Lysine	77-83	PR/SET domain 9	Homo sapiens	8-33
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Lysine	105-118	acid phosphatase 2, lysosomal	Bos taurus	146-172
14300753-0	1965	CARBOXYPEPTIDASE STUDIES ON BETA-GALACTOSIDASE: DETECTION OF ONE C-TERMINAL LYSINE PER MONOMER.	Lysine	76-82	galactosidase beta 1	Homo sapiens	28-46
7354136-3	1980	Lysine and aspartic acid appeared to modify the cholinephosphotransferase reaction in which cytidine 5"-diphosphocholine (CDP-choline) and 1,2-diacylglycerol react to form phosphatidylcholine, the major phospholipid of renal membranes.	Lysine	0-6	cut-like homeobox 1	Rattus norvegicus	122-125
13230041-0	1954	The distribution of radioactivity in crystalline beta-lactoglobulin following the injection of [14C]valine and lysine into a goat.	Lysine	111-117	beta-lactoglobulin	Capra hircus	49-67
33570763-6	2021	Using the combination of SILAC labeling and high-efficiency acetylation enrichment methods, we identified 1372 lysine acetylation(Kac) sites on 796 proteins in CCL18-treated A549 cells.	Lysine	111-117	C-C motif chemokine ligand 18	Homo sapiens	160-165
7354136-5	1980	Lysine increased CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity by 95%, whereas aspartic acid reduced activity by 65%, in a concentration-dependent manner.	Lysine	0-6	cut-like homeobox 1	Rattus norvegicus	17-20
33463678-1	2021	The Arabidopsis plastid-localized ALD1 protein acts in the Lysine-catabolic pathway that produces infection-induced pipecolic acid (Pip), Pip derivatives and basal non-Pip metabolite(s).	Lysine	59-65	AGD2-like defense response protein 1	Arabidopsis thaliana	34-38
6446025-7	1980	Lysine (or arginine residues) or end amino acid NH2-group and cysteine residues HS-group, and some tryptophane residues are at ATPase centre of (Ca--Mg)-ATPase from sarcoplasmic reticulum.	Lysine	0-6	dynein axonemal heavy chain 8	Homo sapiens	127-133
33576509-3	2021	The homologous ubiquitin-conjugating (E2) enzymes Ubc1 (budding yeast) and Ube2K (mammals) exclusively generate polyubiquitin linked through lysine 48 (K48).	Lysine	141-147	ubiquitin	Saccharomyces cerevisiae S288C	15-24
6446025-7	1980	Lysine (or arginine residues) or end amino acid NH2-group and cysteine residues HS-group, and some tryptophane residues are at ATPase centre of (Ca--Mg)-ATPase from sarcoplasmic reticulum.	Lysine	0-6	dynein axonemal heavy chain 8	Homo sapiens	153-159
33576509-5	2021	We found that this UBA domain preferentially interacts with ubiquitin chains linked through lysine 63 (K63).	Lysine	92-98	ubiquitin	Saccharomyces cerevisiae S288C	60-69
84020-6	1979	A direct plaque assay was developed for the detection of IgM anti-GAT plaques using poly-L-lysine (PLL) to couple GAT to sheep erythrocytes (SRBC).	Lysine	84-97	glycine-N-acyltransferase	Mus musculus	66-69
32535965-11	2021	Mass spectrometry revealed that Sirt6 deacetylated conserved lysine 54 on Smad2.	Lysine	61-67	sirtuin 6	Homo sapiens	32-37
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	SMAD family member 2	Homo sapiens	44-51
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	SIX homeobox 1	Homo sapiens	260-264
84020-6	1979	A direct plaque assay was developed for the detection of IgM anti-GAT plaques using poly-L-lysine (PLL) to couple GAT to sheep erythrocytes (SRBC).	Lysine	84-97	glycine-N-acyltransferase	Mus musculus	114-117
34028978-3	2021	RNase A bioreversibly modified with adamantane is functionalized with wind chime-like lysine modified cyclodextrin (WLC) to generate RNase A-WLC (R-WLC).	Lysine	86-92	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
33277444-1	2021	The histone methyltransferase G9A (EHMT2) gene catalyzes methylation of histone 3 lysine 9 (H3K9) and this gene silencing activity contributes to the tumor promoter-like activity of G9A in several tumor types including alveolar rhabdomyosarcoma (ARMS).	Lysine	82-88	euchromatic histone lysine N-methyltransferase 2	Mus musculus	35-40
33277444-1	2021	The histone methyltransferase G9A (EHMT2) gene catalyzes methylation of histone 3 lysine 9 (H3K9) and this gene silencing activity contributes to the tumor promoter-like activity of G9A in several tumor types including alveolar rhabdomyosarcoma (ARMS).	Lysine	82-88	euchromatic histone lysine N-methyltransferase 2	Mus musculus	30-33
86564-1	1979	The binding of FITC-labeled poly-L-ornithine and poly-L-lysine to fresh or neuraminidase treated human, rat or rabbit erythrocytes was investigated by simultaneous cell volume and cell membrane fluorescence measurements in a flow cytometer.	Lysine	49-62	neuraminidase 1	Homo sapiens	75-88
33986254-1	2021	The histone methyltransferase EZH2 silences gene expression via H3 lysine 27 trimethylation and has been recognized as an important antitumour therapeutic target.	Lysine	67-73	PR/SET domain 9	Homo sapiens	4-29
95912-1	1978	A subunit of succinylated (40:1 molar ratio, succinic anhydride:lysine residues) human thyroglobulin (Tg) was prepared by gel filtration on 6% and 4% agarose.	Lysine	64-70	thyroglobulin	Homo sapiens	87-100
33960430-9	2021	Further, we demonstrate HopZ1a suppression of all MKK7-dependent responses, HopZ1a-MKK7 interaction in planta, and HopZ1a acetylation of MKK7 in a lysine required for full kinase activity.	Lysine	147-153	MAP kinase kinase 7	Arabidopsis thaliana	50-54
33960430-9	2021	Further, we demonstrate HopZ1a suppression of all MKK7-dependent responses, HopZ1a-MKK7 interaction in planta, and HopZ1a acetylation of MKK7 in a lysine required for full kinase activity.	Lysine	147-153	MAP kinase kinase 7	Arabidopsis thaliana	83-87
33960430-9	2021	Further, we demonstrate HopZ1a suppression of all MKK7-dependent responses, HopZ1a-MKK7 interaction in planta, and HopZ1a acetylation of MKK7 in a lysine required for full kinase activity.	Lysine	147-153	MAP kinase kinase 7	Arabidopsis thaliana	83-87
33505026-8	2021	METTL3 also interacts physically with the histone 3 lysine 9 (H3K9) tri-methyltransferase SETDB1 and its cofactor TRIM28, and is important for their localization to IAPs.	Lysine	52-58	tripartite motif-containing 28	Mus musculus	114-120
627600-4	1978	We find that the slightly lysine-rich histones (H2A and H2B) but not the arginine-rich histones (H3 and H4) dissociate more slowly from nucleoids containing superhelical DNA than from those containing relaxed DNA.	Lysine	26-32	H2A clustered histone 18	Homo sapiens	48-59
33574035-1	2021	SET8 is solely responsible for histone H4 lysine-20 (H4K20) monomethylation, which preferentially occurs in nucleosomal H4.	Lysine	42-48	lysine methyltransferase 5A	Homo sapiens	0-4
33372411-4	2021	Here, we employ a quantitative proteomics approach to study succinylation in HepG2 cancer cells and find that HAT1 modulates lysine succinylation on various proteins including histones and non-histones.	Lysine	125-131	histone acetyltransferase 1	Homo sapiens	110-114
33382614-5	2021	The subsequent application of AcH to label RNase A without and with ligands has assisted to assign lysines involved in ligand-RNase A binding by detecting the time-dependent changes in accessibility profiles.	Lysine	99-106	ribonuclease A family member 1, pancreatic	Homo sapiens	43-50
33382614-5	2021	The subsequent application of AcH to label RNase A without and with ligands has assisted to assign lysines involved in ligand-RNase A binding by detecting the time-dependent changes in accessibility profiles.	Lysine	99-106	ribonuclease A family member 1, pancreatic	Homo sapiens	126-133
32979540-3	2021	Maintenance and formation of heterochromatin critically depends on epigenetic regulators that recognize histone 3 lysine trimethylation at residues K9 and K27 (respectively, H3K9me3 and H3K27me3), which represent transcriptionally suppressive epigenetic marks.	Lysine	114-120	keratin 27	Homo sapiens	155-158
33376515-1	2021	With no lysine 4 (WNK4) is a serine/threonine kinase, which is expressed in the kidney and associated with salt-sensitive hypertension.	Lysine	8-14	WNK lysine deficient protein kinase 4	Mus musculus	18-22
33376515-6	2021	It was also identified that the Lys-1023 site was the most important ubiquitination site for WNK4, and it was found that phosphorylation at the Ser-1022 site was a prerequisite for ubiquitination.	Lysine	32-35	WNK lysine deficient protein kinase 4	Mus musculus	93-97
33528599-6	2021	A previously identified Asn-to-Lys anticodon shift substitution in D. ananassae may have arisen to compensate for the convergent and parallel gains of C17 in tRNAAsn paralogs in that lineage.	Lysine	31-34	transfer RNA:Asparagine-GTT 1-1	Drosophila melanogaster	158-165
33536620-4	2021	Here we identify the histone H3 lysine 36 (H3K36) methyltransferase NSD3, the gene for which is located in the 8p11-12 amplicon, as a key regulator of LUSC tumorigenesis.	Lysine	32-38	nuclear receptor binding SET domain protein 3	Homo sapiens	68-72
33420361-6	2021	Furthermore, we found that CREB could recruit MMSET, leading to the stabilization of HIF-1alpha protein and the increased dimethylation of histone H3 at lysine 36 on the DKK1 promoter.	Lysine	153-159	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	170-174
33535351-1	2021	The human epigenetic gene of SET domain containing 2 (SETD2) is located at the cytogenetic band p21.31 of chromosome 3, which encodes the histone3 lysine36 trimethyltransferase SETD2, the major enzyme that catalyzes the trimethylation of lysine 36 on histone 3 (H3K36me3) of human.	Lysine	147-153	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	29-52
33535351-1	2021	The human epigenetic gene of SET domain containing 2 (SETD2) is located at the cytogenetic band p21.31 of chromosome 3, which encodes the histone3 lysine36 trimethyltransferase SETD2, the major enzyme that catalyzes the trimethylation of lysine 36 on histone 3 (H3K36me3) of human.	Lysine	147-153	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	54-59
33535351-1	2021	The human epigenetic gene of SET domain containing 2 (SETD2) is located at the cytogenetic band p21.31 of chromosome 3, which encodes the histone3 lysine36 trimethyltransferase SETD2, the major enzyme that catalyzes the trimethylation of lysine 36 on histone 3 (H3K36me3) of human.	Lysine	147-153	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	177-182
33472082-5	2021	Through modification of SQSTM1/p62 on lysine 435, the ER-embedded UBE2J1/RNF26 ubiquitylation complex recruits endosomal adaptors to immobilize their cognate vesicles in the perinuclear region of the cell.	Lysine	38-44	epiregulin	Homo sapiens	54-56
33453107-8	2021	Redox-based PTMs mostly occur in the cysteine thiol group (oxidation, S-nitrosylation, S-glutathionylation, persulfidation), but also in methionine (oxidation), tyrosine (nitration), and lysine and arginine (carbonylation/glycation) residues.	Lysine	187-193	parathymosin	Homo sapiens	12-16
33467728-0	2021	Substrate Scope for Human Histone Lysine Acetyltransferase KAT8.	Lysine	34-40	lysine acetyltransferase 8	Homo sapiens	59-63
33467728-1	2021	Biomedically important histone lysine acetyltransferase KAT8 catalyses the acetyl coenzyme A-dependent acetylation of lysine on histone and other proteins.	Lysine	31-37	lysine acetyltransferase 8	Homo sapiens	56-60
33467728-1	2021	Biomedically important histone lysine acetyltransferase KAT8 catalyses the acetyl coenzyme A-dependent acetylation of lysine on histone and other proteins.	Lysine	118-124	lysine acetyltransferase 8	Homo sapiens	56-60
33467728-2	2021	Here, we explore the ability of human KAT8 to catalyse the acetylation of histone H4 peptides possessing lysine and its analogues at position 16 (H4K16).	Lysine	105-111	lysine acetyltransferase 8	Homo sapiens	38-42
33467728-3	2021	Our synthetic and enzymatic studies on chemically and structurally diverse lysine mimics demonstrate that KAT8 also has a capacity to acetylate selected lysine analogues that possess subtle changes on the side chain and main chain.	Lysine	75-81	lysine acetyltransferase 8	Homo sapiens	106-110
33467728-3	2021	Our synthetic and enzymatic studies on chemically and structurally diverse lysine mimics demonstrate that KAT8 also has a capacity to acetylate selected lysine analogues that possess subtle changes on the side chain and main chain.	Lysine	153-159	lysine acetyltransferase 8	Homo sapiens	106-110
33467728-4	2021	Overall, this work highlights that KAT8 has a broader substrate scope beyond natural lysine, and contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase (KAT) family.	Lysine	85-91	lysine acetyltransferase 8	Homo sapiens	35-39
33467728-4	2021	Overall, this work highlights that KAT8 has a broader substrate scope beyond natural lysine, and contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase (KAT) family.	Lysine	194-200	lysine acetyltransferase 8	Homo sapiens	35-39
33467728-4	2021	Overall, this work highlights that KAT8 has a broader substrate scope beyond natural lysine, and contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase (KAT) family.	Lysine	194-200	lysine acetyltransferase 8	Homo sapiens	156-160
33431796-11	2021	One of the important mechanisms is that inhibition HDAC2 to reduce pyroptosis may be by modulating the K68 lysine site of ULK1.	Lysine	107-113	unc-51 like autophagy activating kinase 1	Homo sapiens	122-126
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	5'-nucleotidase ecto	Homo sapiens	92-96
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	platelet and endothelial cell adhesion molecule 1	Homo sapiens	108-112
33170804-7	2021	Using quantitative proteomics, we identified the ubiquitinated lysine residues on mutant AR that are regulated by USP7.	Lysine	63-69	ubiquitin specific peptidase 7	Mus musculus	114-118
33112158-8	2021	Methylation-selective PCR (MSP) confirmed maternal HF diet increased RNA polymerase II, acetylation of histone H4, and dimethylation of Histone 3 lysine 4 at the +6kb region of Il4.	Lysine	146-152	interleukin 4	Rattus norvegicus	177-180
33478272-1	2021	We report the identification of a novel, high oxygen affinity hemoglobin (Hb) variant [alpha127(H10)Lys Gln; HBA1: c.382A>C].	Lysine	100-103	hemoglobin subunit alpha 1	Homo sapiens	109-113
34035635-4	2021	Tranexamic acid is known to competitively block the lysine-binding site of plasminogen and thus inhibit the activation of plasminogen to plasmin and at high-concentration tranexamic acid noncompetitively blocks plasmin, thus inhibiting the dissolution and degradation of fibrin clots by plasmin.	Lysine	52-58	plasminogen	Homo sapiens	75-82
34035635-4	2021	Tranexamic acid is known to competitively block the lysine-binding site of plasminogen and thus inhibit the activation of plasminogen to plasmin and at high-concentration tranexamic acid noncompetitively blocks plasmin, thus inhibiting the dissolution and degradation of fibrin clots by plasmin.	Lysine	52-58	plasminogen	Homo sapiens	122-129
34035635-4	2021	Tranexamic acid is known to competitively block the lysine-binding site of plasminogen and thus inhibit the activation of plasminogen to plasmin and at high-concentration tranexamic acid noncompetitively blocks plasmin, thus inhibiting the dissolution and degradation of fibrin clots by plasmin.	Lysine	52-58	plasminogen	Homo sapiens	122-129
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Lysine	40-43	Auxin efflux carrier family protein	Arabidopsis thaliana	112-116
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Lysine	40-43	Auxin efflux carrier family protein	Arabidopsis thaliana	149-153
33425909-1	2020	Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds.	Lysine	142-148	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	6-37
33425909-1	2020	Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds.	Lysine	142-148	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	39-43
32990813-7	2020	Beads with immobilized poly-L-lysine bind heme but Lf inhibits this binding.	Lysine	23-36	HEME	Bos taurus	42-46
33164119-9	2020	Protein glycation takes place primarily in lysine residues, which are less abundant in chicken than in bovine serum albumin.	Lysine	43-49	albumin	Gallus gallus	110-123
33164119-10	2020	A multispecies comparison of serum albumin sequences revealed lower numbers of lysine residues in birds than in mammals.	Lysine	79-85	albumin	Gallus gallus	29-42
32868895-5	2020	Our covalent lead-compound BT5-demonstrates on-target activity in NUP98-NSD1 leukemia cells, including inhibition of histone H3 lysine 36 dimethylation and downregulation of target genes, and impaired colony formation in an NUP98-NSD1 patient sample.	Lysine	128-134	nucleoporin 98 and 96 precursor	Homo sapiens	66-71
33330095-0	2020	Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins.	Lysine	0-6	ribophorin II	Homo sapiens	133-137
33330095-9	2020	We found that lysine was the most utilized EAA in human ER+BC in vivo.	Lysine	14-20	epiregulin	Homo sapiens	56-58
33330095-10	2020	In zebrafish, lysine in presence of E2 increased neutrophil-dependent dissemination of ER+ BC cells via upregulation of U2AF1 and RPN2 proteins, which both correlated with poor prognosis of ER+ BC patients in clinical databases.	Lysine	14-20	U2 small nuclear RNA auxiliary factor 1	Danio rerio	120-125
33330095-12	2020	Dietary lysine or its related metabolic pathways may be useful therapeutic targets in ER+ BC.	Lysine	8-14	epiregulin	Homo sapiens	86-88
33244033-5	2020	We found that the SMYD3 lysine methyltransferase is spatially redistributed dependent on cell geometry (cell shape and aspect ratio) in murine myoblasts.	Lysine	24-30	SET and MYND domain containing 3	Mus musculus	18-23
33244033-8	2020	The distribution of SMYD3 in response to cell geometry correlated with cytoplasmic and nuclear lysine tri-methylation (Kme3) levels, but not Kme2.	Lysine	95-101	SET and MYND domain containing 3	Mus musculus	20-25
33223508-1	2020	The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be frequently mutated or deleted in many types of human cancer.	Lysine	15-21	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	43-66
33223508-1	2020	The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be frequently mutated or deleted in many types of human cancer.	Lysine	15-21	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	68-73
33211010-1	2020	Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3).	Lysine	94-100	Polycomb	Drosophila melanogaster	23-31
33202645-5	2020	Historically, PRC1 was considered to be a transcription repressor that deposited monoubiquitylation of histone H2A at lysine 119 (H2AK119ub1) and compacted local chromatin.	Lysine	118-124	protein regulator of cytokinesis 1	Homo sapiens	14-18
33187986-6	2021	We show that acetylation of two key lysine residues on TULP3 by p300 increases TULP3 protein abundance, and that deacetylation of these sites by HDAC1 decreases protein levels.	Lysine	36-42	E1A binding protein p300	Homo sapiens	64-68
33157086-4	2021	Hyperphosphorylated BMI-1 undergoes canonical polycomb E3 ligase function loss, thereby leads to reduce monoubiquitylation of histone 2A at lysine 119 (H2AK119ub) corroborates cellular accumulation of alpha-synuclein protein phosphorylated at serine 129 (palpha-SYN (S129).	Lysine	140-146	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	20-25
32952025-13	2020	A linear effect was detected for MPO, NFKB1, and SOD1 due to greater fold-change in abundance when Met was increased to reach Lys:Met ratios of 2.9:1 and 2.4:1.	Lysine	126-129	superoxide dismutase [Cu-Zn]	Bos taurus	49-53
33254553-4	2020	In fact, in a single ACE2 molecule, 34 lysine residues are present in the extracellular portion, and at least one of these is co-involved in a fundamental hydrogen-bond interaction with the SARS-CoV-2 receptor binding domain (RBD).	Lysine	39-45	angiotensin converting enzyme 2	Homo sapiens	21-25
33950564-3	2021	PRC2 trimethylates histone H3 lysine 27 (H3K27me3), a histone mark recognized by the N-terminal chromodomain (ChD) of the CBX subunit of canonical PRC1.	Lysine	30-36	protein regulator of cytokinesis 1	Homo sapiens	147-151
33951227-4	2021	It was found that the binding of ACE2 to SARS-CoV-2-RBD involved two core regions (31st and 353rd lysine) and 20 amino acids of the ACE2 protein.	Lysine	98-104	angiotensin converting enzyme 2	Homo sapiens	33-37
33939216-9	2021	Further mechanism studies demonstrated that ZNF213 associated with YAP and facilitated YAP K48-linked poly-ubiquitination at several YAP lysine sites (K252, K254, K321 and K497).	Lysine	137-143	Yes1 associated transcriptional regulator	Homo sapiens	87-90
33977095-11	2021	The recruitment of WDR5 to the promoter of these target genes upregulated the histone H3 lysine 4 trimethylation (H3K4me3) level in these regions and further induced the transcription of MMP2, MMP9, CDK1, CDK2, and CDK4.	Lysine	89-95	WD repeat domain 5	Mus musculus	19-23
33977095-11	2021	The recruitment of WDR5 to the promoter of these target genes upregulated the histone H3 lysine 4 trimethylation (H3K4me3) level in these regions and further induced the transcription of MMP2, MMP9, CDK1, CDK2, and CDK4.	Lysine	89-95	matrix metallopeptidase 9	Mus musculus	193-197
33977095-11	2021	The recruitment of WDR5 to the promoter of these target genes upregulated the histone H3 lysine 4 trimethylation (H3K4me3) level in these regions and further induced the transcription of MMP2, MMP9, CDK1, CDK2, and CDK4.	Lysine	89-95	cyclin-dependent kinase 1	Mus musculus	199-203
33927350-0	2021	Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS.	Lysine	13-19	mitochondrial ribosomal protein S23	Homo sapiens	35-41
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	mitochondrial ribosomal protein S23	Homo sapiens	76-111
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	mitochondrial ribosomal protein S23	Homo sapiens	113-119
33846303-5	2021	Mechanistically, TRIM39 interacts with Rab7 and promotes its activity via inhibiting its ubiquitination at lysine 191 residue.	Lysine	107-113	RAB7B, member RAS oncogene family	Homo sapiens	39-43
33582133-6	2021	We show that both the number and the position of phosphorylated threonines/serines or acetylated lysines can serve as a molecular on/off switch for phase separation in the well-studied disordered regions of FUS and DDX3X, respectively.	Lysine	97-104	DEAD-box helicase 3 X-linked	Homo sapiens	215-220
33823156-1	2021	The methyltransferases MLL3 and MLL4 primarily catalyze the mono-methylation of histone H3 lysine 4 (H3K4) on enhancers to regulate cell-type-specific gene expression and cell fate transition.	Lysine	91-97	lysine methyltransferase 2C	Homo sapiens	23-27
33823156-1	2021	The methyltransferases MLL3 and MLL4 primarily catalyze the mono-methylation of histone H3 lysine 4 (H3K4) on enhancers to regulate cell-type-specific gene expression and cell fate transition.	Lysine	91-97	lysine methyltransferase 2B	Homo sapiens	32-36
33037615-7	2021	Further analyses revealed that the TRPM8 N-terminal lysine residue at 423 was the major ubiquitination site that mediates its functional regulation by TRIM4.	Lysine	52-58	transient receptor potential cation channel subfamily M member 8	Homo sapiens	35-40
33359755-4	2021	Here, we identify interactions between the histone H3 lysine 27 trimethylation (H3K27me3) - demethylase JMJD3, the SWI/SNF remodeling complex subunit BRG1, and cardiac transcription factors.	Lysine	54-60	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	150-154
33744855-1	2021	The regulation of mTOR and the dimethylation of histone H3 on lysine 9 (H3K9me2) H3K9me2 by Uhrf1 and the mechanism of autophagy regulation in myocardial ischemia-reperfusion injury (MIRI) were studied in vivo and in vitro.	Lysine	62-68	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	92-97
33485945-8	2021	In the second series of experiments, the mGlu2/3 orthosteric agonist LY-354,740 and EMD-281,014, either alone or in combination, were added to L-DOPA.	Lysine	69-71	glutamate receptor, metabotropic 3	Mus musculus	41-48
33616410-1	2021	Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics, cellular processes, and disease procession.	Lysine	61-67	delta/notch like EGF repeat containing	Homo sapiens	31-34
33684277-2	2021	In addition, the patient, his sister, mother and maternal grandfather had intermittently increased plasma arginine and lysine levels, most probably due to heterozygosity for a novel pathogenic SLC7A2 variant.	Lysine	119-125	solute carrier family 7 member 2	Homo sapiens	193-199
33387462-8	2021	Furthermore, immunoprecipitation and use of a lysine acetylation assay showed that Sirtuin1 (SIRT1) mediated the PGC-1alpha deacetylation, which is involved in Nlrp3 inflammasome activation.	Lysine	46-52	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	113-123
33649337-4	2021	In vitro, S100beta/Sca1 cells isolated from atheroprone regions of the mouse aorta expressed hedgehog signalling components, acquired the di-methylation of histone 3 lysine 4 (H3K4me2) stable SMC epigenetic mark at the Myh11 locus and underwent myogenic differentiation in response to recombinant sonic hedgehog (SHh).	Lysine	166-172	S100 calcium binding protein A1	Mus musculus	10-18
33479498-2	2021	SIRT5 removes negatively charged malonyl, succinyl, and glutaryl groups from lysine residues and thereby regulates multiple enzymes involved in cellular metabolism and other biological processes.	Lysine	77-83	sirtuin 5	Mus musculus	0-5
33632299-1	2021	BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer.	Lysine	30-36	euchromatic histone lysine N-methyltransferase 2	Mus musculus	137-140
33632299-1	2021	BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer.	Lysine	61-67	euchromatic histone lysine N-methyltransferase 2	Mus musculus	137-140
33594440-10	2021	Lys 297 was identified as the main target of SUMO3 in the phot2 molecule.	Lysine	0-3	small ubiquitin-like modifier 3	Arabidopsis thaliana	45-50
33594440-10	2021	Lys 297 was identified as the main target of SUMO3 in the phot2 molecule.	Lysine	0-3	phototropin 2	Arabidopsis thaliana	58-63
33680286-6	2021	Furthermore, deletion of GCN5L1 could reduce MnSOD acetylation on lysine 68 and activate its activity, thereby scavenging excessive ROS and relieving oxidative stress-induced renal inflammation and fibrosis.	Lysine	66-72	superoxide dismutase 2	Homo sapiens	45-50
33589584-4	2021	Overexpressed histone methyltransferase NSD2 in patients bearing a t(4;14) translocation or in BTZ-resistant MM cells coordinates elevated SRC-3 by enhancing its liquid-liquid phase separation to supranormally modify histone H3 lysine 36 dimethylation (H3K36me2) modifications on promoters of anti-apoptotic genes.	Lysine	228-234	PR/SET domain 9	Homo sapiens	14-39
33574238-2	2021	In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark of trimethylated lysine 4 and lysine 9 present on the same histone H3 tail (H3K4me3K9me3).	Lysine	179-185	spindlin interactor and repressor of chromatin binding	Homo sapiens	97-105
33574238-2	2021	In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark of trimethylated lysine 4 and lysine 9 present on the same histone H3 tail (H3K4me3K9me3).	Lysine	192-198	spindlin interactor and repressor of chromatin binding	Homo sapiens	97-105
33546767-7	2021	We found that inhibition of NAMPT or SIRT2 in iPS cells induces p53 protein by promoting its lysine acetylation.	Lysine	93-99	nicotinamide phosphoribosyltransferase	Homo sapiens	28-33
33539881-2	2021	The central ATPase of BAF is either BRM or BRG1, both of which contain a C-terminal bromodomain, known to associate with acetylated lysines.	Lysine	132-139	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	43-47
33539881-3	2021	We have recently demonstrated that in addition to acetyl-lysine binding, the BRG1/BRM bromodomain can associate with DNA through a lysine/arginine rich patch that is adjacent to the acetyl-lysine binding pocket.	Lysine	57-63	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	77-81
32895487-8	2021	We identified the lysine 133 (K133) residue in Oct4 as a ubiquitination site responsible for the Kap1-Itch-dependent regulation of Oct4 stability.	Lysine	18-24	tripartite motif-containing 28	Mus musculus	97-101
33575219-9	2020	TBX1 silencing inhibited the monomethylation of histone 3 lysine 4 (H3K4me1) binding with the non-coding intergenic spacer (IGS) regions of ribosomal DNA (rDNA) and the recruitment of upstream binding factor to the promoter and IGS regions of rDNA.	Lysine	58-64	T-box transcription factor 1	Homo sapiens	0-4
33493517-8	2021	In vitro Hsf1 is primarily conjugated at lysine 298 with a single SUMO, though we did detect low level SUMOylation at other sites.	Lysine	41-47	heat shock transcription factor 1	Homo sapiens	9-13
33520978-7	2020	It has been confirmed that miR-202-3p negatively regulated KDM3A responsible for increasing the expression of HOXA1 by eliminating the histone H3 lysine 9 (H3K9)me2 in HCC cells.	Lysine	146-152	homeobox A1	Homo sapiens	110-115
33313896-5	2021	Several histone acetyltransferases were found to possess lysine isobutyryltransferase activity in vitro, especially p300 and HAT1.	Lysine	57-63	E1A binding protein p300	Homo sapiens	116-120
33313896-5	2021	Several histone acetyltransferases were found to possess lysine isobutyryltransferase activity in vitro, especially p300 and HAT1.	Lysine	57-63	histone acetyltransferase 1	Homo sapiens	125-129
33934885-4	2021	In this article, we describe a new role for the ubiquitin-proteasome system in histone crosstalk, showing that learning-induced monoubiquitination of histone H2B (H2Bubi) is required for increases in the transcriptionally active H3 lysine 4 trimethylation (H3K4me3) mark at learning-related genes in the hippocampus.	Lysine	232-238	H2B clustered histone 12	Rattus norvegicus	150-161
33414395-10	2021	Specifically, FAT10 bound to the lysine residues in the C-terminal fragments of Nav1.5 and decreased the binding of Nav1.5 to the Nedd4-2 protein, a ubiquitin E3 ligase, preventing degradation of the Nav1.5 protein.	Lysine	33-39	ubiquitin D	Mus musculus	14-19
33397384-3	2021	Therefore, we designed this study to investigate effects of SUV39H2 in OS meditated by the lysine specific demethylase-1/E-cadherin (LSD1/CDH1) axis.	Lysine	91-97	SUV39H2 histone lysine methyltransferase	Homo sapiens	60-67
32739762-4	2021	WT1 includes the variants WT1(+KTS) and WT1(-KTS), which differ by 3 amino acids KTS (lysine, threonine, and serine).	Lysine	86-92	WT1	Bos taurus	0-3
32739762-4	2021	WT1 includes the variants WT1(+KTS) and WT1(-KTS), which differ by 3 amino acids KTS (lysine, threonine, and serine).	Lysine	86-92	WT1	Bos taurus	26-29
32739762-4	2021	WT1 includes the variants WT1(+KTS) and WT1(-KTS), which differ by 3 amino acids KTS (lysine, threonine, and serine).	Lysine	86-92	WT1	Bos taurus	26-29
32801161-6	2020	We demonstrate that the PRC1 complex member RING1A mediates monoubiquitination of lysine 119 of phosphorylated H2AX (gammaH2AXub1) at sites of platinum DNA damage in OC cells.	Lysine	82-88	ring finger protein 1	Homo sapiens	44-50
32801161-6	2020	We demonstrate that the PRC1 complex member RING1A mediates monoubiquitination of lysine 119 of phosphorylated H2AX (gammaH2AXub1) at sites of platinum DNA damage in OC cells.	Lysine	82-88	H2A.X variant histone	Homo sapiens	111-115
33127950-3	2020	Here, we demonstrate that K8- as well as K-16 peptides (containing 8 and 16 lysine residues with dissociation constants of 102 nM and 11.6 nM for phosphatidylserine, respectively) immobilized on magnetic beads can capture small EVs (< 0.2 microm) from culture supernatants of MCF7 human breast cancer cells.	Lysine	76-82	keratin 16	Homo sapiens	41-45
665080-0	1978	Lysine tRNAs from cytoplasm, chloroplasts and mitochondria of the lupin seedling cotyledons.	Lysine	0-6	5'-nucleotidase, cytosolic IIIA	Homo sapiens	66-71
33126484-1	2020	N-alpha-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins.	Lysine	117-123	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	0-28
33126484-1	2020	N-alpha-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins.	Lysine	117-123	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	30-35
33532024-6	2021	Mechanistically, we demonstrated that SIRT6 interacted with transcription factor p65 (NF-kB subunit) and deacetylated histone H3 lysine 9 (H3K9) and lysine 56 (H3K56) at the promoter of SNAIL, leading to reduced transcription of SNAIL.	Lysine	129-135	sirtuin 6	Homo sapiens	38-43
33532024-6	2021	Mechanistically, we demonstrated that SIRT6 interacted with transcription factor p65 (NF-kB subunit) and deacetylated histone H3 lysine 9 (H3K9) and lysine 56 (H3K56) at the promoter of SNAIL, leading to reduced transcription of SNAIL.	Lysine	149-155	sirtuin 6	Homo sapiens	38-43
999513-8	1976	An analysis of the utilizable parts (flesh, stomach, heart, liver, follicles, fat) for crude nutrients showed that the heavier birds receiving adequate amounts of lysine contained less crude protein and more crude fat than the smaller birds.	Lysine	163-169	FAT atypical cadherin 1	Gallus gallus	214-217
32605929-9	2021	Notably, by reducing methylation levels on histone H3 lysine 9, JMJD1 proteins can profoundly alter the transcriptome and thereby affect tumorigenesis, including through upregulating oncogenes such as CCND1, JUN and MYC.	Lysine	54-60	myelocytomatosis oncogene	Mus musculus	216-219
33274335-0	2020	A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans.	Lysine	46-52	Ribosomal protein S6 kinase beta	Caenorhabditis elegans	56-62
401-6	1976	No complexation occurred when cytochrome c was acetylated on 64% of its lysine residues or photooxidized on its 2 methionine residues.	Lysine	72-78	LOC104968582	Bos taurus	30-42
33007159-4	2020	We identified two additional lysine residues in the alpha1 GlyR extracellular domain, K16 and K281, that were involved in glucose modulation.	Lysine	29-35	keratin 16	Homo sapiens	86-89
33300088-1	2021	Mutations in Lysine-Specific Histone Methyltransferase 2B gene (KMT2B) have been reported to be associated with isolated and complex early-onset generalized dystonia.	Lysine	13-19	lysine methyltransferase 2B	Homo sapiens	64-69
401-7	1976	Complexes with molecular ratios of less than 1:1 (i.e. more cytochrome c) were obtained when polymerized cytochrome c, or cytochrome c with all lysine residues guanidinated, or a "1-65 heme peptide" from cyanogen bromide cleavage of cytochrome c was used.	Lysine	144-150	LOC104968582	Bos taurus	60-72
401-8	1976	These results were interpreted to imply that the complex was predominantly maintained by ionic interactions probably involving some of the lysine residues of cytochrome c but with major stabilization dependent on the native conformations of both cytochromes.	Lysine	139-145	LOC104968582	Bos taurus	158-170
33170267-2	2020	In Arabidopsis thaliana (Arabidopsis), CURLY LEAF (CLF) and SWINGER (SWN) are PRC2 catalytic subunits that repress gene expression through trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	168-174	SET domain-containing protein	Arabidopsis thaliana	39-49
33077812-0	2020	Author Correction: Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.	Lysine	70-76	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	56-61
33077812-0	2020	Author Correction: Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.	Lysine	70-76	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	114-119
33170267-2	2020	In Arabidopsis thaliana (Arabidopsis), CURLY LEAF (CLF) and SWINGER (SWN) are PRC2 catalytic subunits that repress gene expression through trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	168-174	SET domain-containing protein	Arabidopsis thaliana	51-54
1244854-1	1976	The synthesis of elastin by smooth muscle cells was clearly demonstrated by amino acid analyses and the presence of lysine-derived crosslinks.	Lysine	116-122	elastin	Oryctolagus cuniculus	17-24
1244854-5	1976	Further evidence for the synthesis of elastin and collagen was the finding of radiolabelled epsilon-hydroxynorleucine and the reduced aldol condensate of two residues of allysine after reduction of [14C] lysine pulsed cells with NaBH4.	Lysine	172-178	elastin	Oryctolagus cuniculus	38-45
33070155-7	2020	We demonstrate that RNF40-driven H2B monoubiquitination is essential for transcriptional activation of RHO/ROCK/LIMK pathway components and proper actin-cytoskeleton dynamics through a trans-histone crosstalk with histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	224-230	LIM domain kinase 1	Homo sapiens	112-116
1089655-7	1975	The role of lysine in the action of yeast phosphoglycerate kinase has been studied by modification with O-methylisourea, 2-methoxy-5-nitrotropone, and pyridoxal phosphate.	Lysine	12-18	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	42-65
33311489-10	2020	The UCSC database was used to predict that acetylation of histone H3 at lysine 27 (H3K27ac) induces binding to the PSTPIP2 promoter, and this prediction was validated by a ChIP assay.	Lysine	72-78	proline-serine-threonine phosphatase interacting protein 2	Homo sapiens	115-122
1089655-8	1975	Guanidination shows that there are lysines essential for phosphoglycerate kinase; extrapolation to zero activity indicates that there are three essential lysines as judged by nitrotroponylation and three essential lysines when the enzyme is reacted with pyridoxal phosphate.	Lysine	35-42	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	57-80
33424924-7	2020	Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the host genes of the DE circRNAs showed that the host genes were enriched in lipid metabolism related GO terms (e.g., fatty acid beta-oxidation using acyl-CoA dehydrogenase and MLL3/4 complex), and signaling pathways (e.g., TGF-beta and lysine degradation signaling pathway).	Lysine	339-345	lysine methyltransferase 2C	Homo sapiens	279-285
32542325-0	2020	Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.	Lysine	0-6	K(lysine) acetyltransferase 5	Mus musculus	25-30
5688828-0	1968	The reactive lysine residue at the allosteric site of sheep kidney pyruvate carboxylase.	Lysine	13-19	pyruvate carboxylase, mitochondrial	Ovis aries	67-87
32763975-5	2020	Here, we present evidence that FAAP20 is acetylated by the acetyltransferase p300/CBP on lysine 152, the key residue which when polyubiquitinated results in the degradation of FAAP20.	Lysine	89-95	E1A binding protein p300	Homo sapiens	77-81
32394628-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing tri-methylation marks at lysine 27 of histone H3 (H3K27me3).	Lysine	278-284	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	156-178
32394628-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing tri-methylation marks at lysine 27 of histone H3 (H3K27me3).	Lysine	278-284	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	180-185
33424924-7	2020	Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the host genes of the DE circRNAs showed that the host genes were enriched in lipid metabolism related GO terms (e.g., fatty acid beta-oxidation using acyl-CoA dehydrogenase and MLL3/4 complex), and signaling pathways (e.g., TGF-beta and lysine degradation signaling pathway).	Lysine	339-345	transforming growth factor alpha	Homo sapiens	326-334
6029606-3	1967	Of the 19 lysine residues in sperm-whale myoglobin, three did not react with 3,3-tetramethyleneglutaric anhydride.	Lysine	10-16	myoglobin	Physeter catodon	41-50
33519470-1	2020	MOF is a well-known histone acetyltransferase to catalyze acetylation of histone H4 lysine 16 (K16), and it is relevant to diverse biological processes, such as gene transcription, cell cycle, early embryonic development and tumorigenesis.	Lysine	84-90	lysine acetyltransferase 8	Homo sapiens	0-3
32883578-7	2020	However, deletion of the di-lysine motif or substitution of lysines in the motif for alanines, severely impaired glucuronidation activity of UGT1A9.	Lysine	60-67	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	141-147
33519470-1	2020	MOF is a well-known histone acetyltransferase to catalyze acetylation of histone H4 lysine 16 (K16), and it is relevant to diverse biological processes, such as gene transcription, cell cycle, early embryonic development and tumorigenesis.	Lysine	84-90	keratin 16	Homo sapiens	95-98
33036756-3	2021	The histone methyltransferase SETD2, frequently inactivated in ccRCC, has recently been shown to also methylate cytoskeletal proteins, which in the case of actin lysine 68 trimethylation (ActK68me3) regulates actin polymerization dynamics.	Lysine	162-168	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	30-35
33127342-1	2020	SETD8 is a lysine methyltransferase containing an SET domain, which is involved in the carcinogenesis of many cancer types through monomethylation of the histone H4 lysine 20.	Lysine	11-17	lysine methyltransferase 5A	Homo sapiens	0-5
33127342-1	2020	SETD8 is a lysine methyltransferase containing an SET domain, which is involved in the carcinogenesis of many cancer types through monomethylation of the histone H4 lysine 20.	Lysine	165-171	lysine methyltransferase 5A	Homo sapiens	0-5
32096906-2	2020	The L-lysine proton-symporter Lyp1 of Saccharomyces cerevisiae is special in that the Michaelis constant from out to in transport (Km out in ) is much lower than Km in out , which allows accumulation of L-lysine to submolar concentration.	Lysine	4-12	lysine permease	Saccharomyces cerevisiae S288C	30-34
32096906-2	2020	The L-lysine proton-symporter Lyp1 of Saccharomyces cerevisiae is special in that the Michaelis constant from out to in transport (Km out in ) is much lower than Km in out , which allows accumulation of L-lysine to submolar concentration.	Lysine	203-211	lysine permease	Saccharomyces cerevisiae S288C	30-34
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Lysine	64-67	Eph receptor A4	Rattus norvegicus	112-117
33173537-8	2020	The changes in Pttg1 expression were accompanied by consistent alterations in histone H3 lysine 4 trimethylation at Pttg1 transcription start site.	Lysine	89-95	pituitary tumor-transforming gene 1	Mus musculus	15-20
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Lysine	167-173	myosin light chain 3	Homo sapiens	29-33
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Lysine	64-67	Eph receptor A4	Rattus norvegicus	197-202
32790646-1	2020	Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible for familial hyperkalemic hypertension (FHHt), a rare, inherited disorder characterized by arterial hypertension and hyperkalemia with metabolic acidosis.	Lysine	38-44	WNK lysine deficient protein kinase 1	Homo sapiens	52-56
33173537-8	2020	The changes in Pttg1 expression were accompanied by consistent alterations in histone H3 lysine 4 trimethylation at Pttg1 transcription start site.	Lysine	89-95	pituitary tumor-transforming gene 1	Mus musculus	116-121
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Lysine	256-259	SLC2A4 regulator	Homo sapiens	47-50
32939018-0	2020	Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.	Lysine	51-57	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	37-42
33298871-7	2020	LncLy6C not only bound with transcription factor C/EBPbeta but also bound with multiple lysine methyltransferases of H3K4me3 to specifically promote the enrichment of C/EBPbeta and H3K4me3 marks on the promoter region of Nr4A1, which can promote Ly6Chigh into Ly6Cneg macrophages.	Lysine	88-94	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	167-176
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Lysine	256-259	SLC2A4 regulator	Homo sapiens	66-71
32900482-4	2020	In this study, we found IDH2 is modified by small ubiquitin-like modifier 1 (SUMO1) at lysine 45.	Lysine	87-93	small ubiquitin like modifier 1	Homo sapiens	44-75
32939018-1	2020	SETD2 catalyzes methylation at lysine 36 of histone H3 and it has many disease connections.	Lysine	31-37	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
32939018-6	2020	We solved the structure of SETD2 with bound super-substrate peptide containing a target lysine to methionine mutation, which revealed better interactions involving three of the substituted residues.	Lysine	88-94	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	27-32
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Lysine	260-263	SLC2A4 regulator	Homo sapiens	47-50
32895473-5	2020	Here, we report the utility of AA in the prevention of TET2MT myeloid neoplasia (MN), clarify the mechanistic underpinning of the TET2-AA interactions, and demonstrate that the ability of AA to restore TET2 activity in cells depends on N- and C-terminal lysine acetylation and nature of TET2MT.	Lysine	254-260	tet methylcytosine dioxygenase 2	Homo sapiens	130-134
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Lysine	260-263	SLC2A4 regulator	Homo sapiens	66-71
34036992-3	2021	The presented in vitro validation of covalently acting "furan-armed" Tbeta4-variants provides initial proof to further exploit furan-technology for covalent drug design targeting lysines.	Lysine	179-186	trace amine associated receptor 6	Homo sapiens	69-75
32710489-2	2020	Specifically, SETD2 is associated with trimethylation of histone H3 at lysine 36 (H3K36me3) and methylation of alpha-tubulin at lysine 40.	Lysine	71-77	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	14-19
32900482-4	2020	In this study, we found IDH2 is modified by small ubiquitin-like modifier 1 (SUMO1) at lysine 45.	Lysine	87-93	small ubiquitin like modifier 1	Homo sapiens	77-82
32710489-2	2020	Specifically, SETD2 is associated with trimethylation of histone H3 at lysine 36 (H3K36me3) and methylation of alpha-tubulin at lysine 40.	Lysine	128-134	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	14-19
34031383-4	2021	LSD1 colocalized with ACE2 at the cell surface to maintain demethylated SARS-CoV-2 spike receptor-binding domain lysine 31 to promote virus-ACE2 interactions.	Lysine	113-119	angiotensin converting enzyme 2	Homo sapiens	22-26
32677374-7	2020	Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells.	Lysine	146-152	Yes1 associated transcriptional regulator	Homo sapiens	207-210
32677374-7	2020	Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells.	Lysine	146-152	Yes1 associated transcriptional regulator	Homo sapiens	238-241
32483381-3	2020	We show here that in addition to phosphorylation, Olig2 is also conjugated by small ubiquitin-like modifier-1 (SUMO1) at three lysine residues K27, K76, and K112.	Lysine	127-133	oligodendrocyte transcription factor 2	Homo sapiens	50-55
32483381-3	2020	We show here that in addition to phosphorylation, Olig2 is also conjugated by small ubiquitin-like modifier-1 (SUMO1) at three lysine residues K27, K76, and K112.	Lysine	127-133	small ubiquitin like modifier 1	Homo sapiens	78-109
32483381-3	2020	We show here that in addition to phosphorylation, Olig2 is also conjugated by small ubiquitin-like modifier-1 (SUMO1) at three lysine residues K27, K76, and K112.	Lysine	127-133	small ubiquitin like modifier 1	Homo sapiens	111-116
34044126-9	2021	We found that p300, which acetylates RelA/p65 at lysine 310, and acetyl-p65 (K310) were downregulated upon CSE treatment.	Lysine	49-55	E1A binding protein p300	Homo sapiens	14-18
33021769-6	2020	SETD2 (histone H3 lysine 36 methyltransferase) is a frequently mutated gene in different types of cancer.	Lysine	18-24	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
32878268-0	2020	The Lysine Specific Demethylase-1 Negatively Regulates the COL9A1 Gene in Human Articular Chondrocytes.	Lysine	4-10	collagen type IX alpha 1 chain	Homo sapiens	59-65
34022460-1	2021	SET8 is the only lysine methyltransferase that can specifically monomethylate the histone H4K20.	Lysine	17-23	lysine methyltransferase 5A	Homo sapiens	0-4
32725200-3	2020	As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltransferase CURLY LEAF (CLF) and its catalyzed histone H3 Lysine 27 trimethylation (H3K27me3) have already become well-established paradigm in plant epigenetic study.	Lysine	153-159	SET domain-containing protein	Arabidopsis thaliana	107-117
32725200-3	2020	As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltransferase CURLY LEAF (CLF) and its catalyzed histone H3 Lysine 27 trimethylation (H3K27me3) have already become well-established paradigm in plant epigenetic study.	Lysine	153-159	SET domain-containing protein	Arabidopsis thaliana	119-122
32973937-4	2020	Lysine acetyltransferase 8 (KAT8) expression, the major lysine acetyltransferase responsible for the acetylation of H4K16, was significantly decreased in patients with AD compared with healthy subjects as determined via western blotting and RT-qPCR.	Lysine	56-62	lysine acetyltransferase 8	Homo sapiens	0-26
32973937-4	2020	Lysine acetyltransferase 8 (KAT8) expression, the major lysine acetyltransferase responsible for the acetylation of H4K16, was significantly decreased in patients with AD compared with healthy subjects as determined via western blotting and RT-qPCR.	Lysine	56-62	lysine acetyltransferase 8	Homo sapiens	28-32
34019788-1	2021	To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological malignancies.	Lysine	208-214	E1A binding protein p300	Homo sapiens	234-238
32726795-5	2020	Inhibition of neddylation, the conjugation of the small ubiquitin-like protein NEDD8 to lysine residues, interrupts degradation of DNMT3A1.	Lysine	88-94	NEDD8 ubiquitin like modifier	Homo sapiens	79-84
32874135-3	2020	Methods: The gene expression patterns and genome-wide regulatory profiles of HCC cells after KLF8 knockout were analyzed by using RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) of histone H3 lysine 27 acetylation (H3K27ac) combined with bioinformatics analysis.	Lysine	225-231	Kruppel like factor 8	Homo sapiens	93-97
34029270-12	2021	Interestingly, ChIP-qCPR analysis revealed that CD40 elimination dampened histone H3 lysine 4 trimethylation (H3K4me3) enrichment at PAI-1, leptin, IL-6 and MCP-1 promoter regions in the presence of rCD40L.	Lysine	85-91	CD40 molecule	Homo sapiens	48-52
32934716-8	2020	In addition, NaB promoted histone H3 acetylation and methylation at lysine 9, as well as MDR1 acetylation, suggesting that acetylation and methylation may be involved in NaB-mediated ABC transporter expression.	Lysine	68-74	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	183-186
32661120-4	2020	In humans, MOF (hMOF), a member of the MYST family of HATs, acetylate histone H4 at lysine 16 (H4K16ac).	Lysine	84-90	lysine acetyltransferase 8	Homo sapiens	39-43
34003795-2	2021	SETDB2 is a member of the KMT1 family of lysine methyltransferases and members of this family typically methylate histone H3 Lys9 (H3K9), an epigenetic mark associated with gene silencing and previous studies have shown SETDB2 is involved in innate and adaptive immunity, the pro-inflammatory response and hepatic lipid metabolism.	Lysine	41-47	SET domain, bifurcated 2	Mus musculus	0-6
32474020-7	2020	In addition, we also found that hypoxia promotes sumoylation in keloids and that HIF-1alpha is covalently modified by SUMO1 at Lys 391 and Lys 477 in HKFs.	Lysine	127-130	small ubiquitin like modifier 1	Homo sapiens	118-123
32888909-8	2020	Noteworthy, most modifications were observed at Lys and His residues located at A-site (K73, K87, K88), L-site (H26, H33, and K27) membrane binding sites.	Lysine	48-51	keratin 27	Homo sapiens	126-129
34003795-2	2021	SETDB2 is a member of the KMT1 family of lysine methyltransferases and members of this family typically methylate histone H3 Lys9 (H3K9), an epigenetic mark associated with gene silencing and previous studies have shown SETDB2 is involved in innate and adaptive immunity, the pro-inflammatory response and hepatic lipid metabolism.	Lysine	41-47	SET domain, bifurcated 2	Mus musculus	220-226
34000373-7	2021	Mechanistically, we show that the thermogenic effect of Dacinostat is achieved by acetylation of histone 3 lysine 27 mediated transcriptional activation of Ucp1 and Ppargc1alpha in adipose tissue.	Lysine	107-113	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	156-160
32768649-6	2020	Molecular docking studies revealed the basic moiety of Lys as detrimental for inhibition of MMP2 as compared to MMP9.	Lysine	55-58	matrix metallopeptidase 2	Homo sapiens	92-96
32806748-2	2020	Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a large number of genes via histone 3 methylation of lysine 27 (H3K27me3).	Lysine	222-228	protein tyrosine kinase 2	Homo sapiens	14-17
34000373-7	2021	Mechanistically, we show that the thermogenic effect of Dacinostat is achieved by acetylation of histone 3 lysine 27 mediated transcriptional activation of Ucp1 and Ppargc1alpha in adipose tissue.	Lysine	107-113	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	165-177
33986537-5	2021	DNMT3A PWWP mutants accumulate at regions containing PRC1-mediated formation of monoubiquitylated histone H2A lysine 119 (H2AK119ub), irrespective of the amounts of PRC2-catalyzed formation of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	110-116	protein regulator of cytokinesis 1	Homo sapiens	53-57
32744498-4	2020	Art2 uses a basic patch to recognize C-terminal acidic sorting motifs in AATs and thereby instructs Rsp5 to ubiquitinate proximal lysine residues.	Lysine	130-136	Ecm21p	Saccharomyces cerevisiae S288C	0-4
32499570-8	2020	Our chromatin immunoprecipitation assay showed that JQ1 reduced the BRD4 binding to the histone H3 lysine 27 acetylation-enriched sites in the MMP2 locus.	Lysine	99-105	matrix metallopeptidase 2	Homo sapiens	143-147
33240782-4	2020	USP38 specifically removes the monoubiquitin on H2B at lysine 120, which functions as a prerequisite for the subsequent recruitment of demethylase KDM5B to the promoters of proinflammatory cytokines Il6 and Il23a during LPS stimulation.	Lysine	55-61	interleukin 23, alpha subunit p19	Mus musculus	207-212
33986537-5	2021	DNMT3A PWWP mutants accumulate at regions containing PRC1-mediated formation of monoubiquitylated histone H2A lysine 119 (H2AK119ub), irrespective of the amounts of PRC2-catalyzed formation of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	218-224	protein regulator of cytokinesis 1	Homo sapiens	53-57
33969633-3	2022	These findings converge on altered post-translational modifications on two key lysine (K) residues of the H3 tail, K27 and K36, which regulate several cellular processes, including those linked to cell differentiation during development.	Lysine	79-85	keratin 27	Homo sapiens	115-118
33027667-2	2020	We report here that PKCepsilon is SUMOylated at a C-terminal lysine residue (K534), which enhances the sensitivity of the TRPV1 channel.	Lysine	61-67	protein kinase C, epsilon	Mus musculus	20-30
32860895-0	2020	Role of lysine residue of islet amyloid polypeptide in fibril formation, membrane binding, and inhibitor binding.	Lysine	8-14	islet amyloid polypeptide	Homo sapiens	26-51
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	E1A binding protein p300	Homo sapiens	35-39
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	delta/notch like EGF repeat containing	Homo sapiens	110-113
32860895-4	2020	Several residues have been suggested to be critical in modulating IAPP amyloid formation, but role of the sole lysine residue at position 1 (Lys-1) in IAPP has not been discussed.	Lysine	141-144	islet amyloid polypeptide	Homo sapiens	151-155
33962629-14	2021	In vitro exposure of monomeric hACE2 to 120 mM glucose for 12 days led to non-enzymatic glycation of four lysine residues in the neck domain affecting the protein oligomerization.	Lysine	106-112	angiotensin converting enzyme 2	Homo sapiens	31-36
32860895-9	2020	Our data also revealed that the inhibitory mechanism of some inhibitors for IAPP aggregation require reaction with Lys-1.	Lysine	115-118	islet amyloid polypeptide	Homo sapiens	76-80
31496375-2	2020	Positively charged lysine side chain improved significantly compound solubility but diminished fluorescence increase upon DPP III binding and completely abolished inhibitory effect on DPP III activity, whereas linker-neutral analogues showed stronger emission increase and were efficient enzyme inhibitors.	Lysine	19-25	dipeptidyl peptidase 3	Homo sapiens	122-129
31496375-2	2020	Positively charged lysine side chain improved significantly compound solubility but diminished fluorescence increase upon DPP III binding and completely abolished inhibitory effect on DPP III activity, whereas linker-neutral analogues showed stronger emission increase and were efficient enzyme inhibitors.	Lysine	19-25	dipeptidyl peptidase 3	Homo sapiens	184-191
32869445-12	2020	Catalpol inhibited the phosphorylation of TAK1 by binding to TAK1, possibly at Asp-206, Thr-208, Asn-211, Glu-297, Lys-294, and Tyr-293.	Lysine	115-118	mitogen-activated protein kinase kinase kinase 7	Mus musculus	42-46
33872013-4	2021	CPP revealed that the accessibility of lysine residues for covalent modification in tubulin-beta (TUBB), in succinate dehydrogenase (SHDB), and in amyloid-beta peptide (Abeta) is altered in human postmortem brain samples of patients with neurodegenerative diseases.	Lysine	39-45	tubulin beta class I	Homo sapiens	98-102
32457045-6	2020	We found PARN is primarily acetylated by the acetyltransferase p300 at Lys-566 and deacetylated by sirtuin1 (SIRT1).	Lysine	71-74	E1A binding protein p300	Homo sapiens	63-67
33755722-4	2021	At the molecular level, DEK recruits the corepressor NCoR1 to repress acetylation of histone 3 at lysine 27 (H3K27ac) and restricts the chromatin accessibility of HSCs, governing the expression of quiescence-associated genes (e.g., Akt1/2, Ccnb2, and p21).	Lysine	98-104	cyclin B2	Homo sapiens	240-245
32694555-2	2020	SETD8, a methyltransferase that catalyzes the mono-methylation of histone H4 lysine 20 is known to promote tumorigenesis in various cancers and its high levels of expression are related to poor prognosis.	Lysine	77-83	lysine methyltransferase 5A	Homo sapiens	0-5
32678070-6	2020	Mechanistically, we found that the protein level of HSD17B4 was regulated by its acetylation at lysine 669(K669).	Lysine	96-102	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	52-59
32597240-6	2020	DNA sequencing confirmed the occurrence of a new heterozygous mutation [HBA1:C.182A G] at codon 60, resulting in a coding change from lysine to arginine.	Lysine	134-140	hemoglobin subunit alpha 1	Homo sapiens	72-76
32978241-6	2020	Further assays indicated that Nedd8 conjugates to Ar and Ar is neddylated at lysine 475 and lysine 862.	Lysine	77-83	NEDD8 ubiquitin like modifier	Danio rerio	30-35
32978241-6	2020	Further assays indicated that Nedd8 conjugates to Ar and Ar is neddylated at lysine 475 and lysine 862.	Lysine	92-98	NEDD8 ubiquitin like modifier	Danio rerio	30-35
33544437-1	2021	The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of histone H4 at lysine 16 (H4K16) and some non-histone proteins.	Lysine	96-102	lysine acetyltransferase 8	Homo sapiens	35-39
32760426-8	2020	The GO analysis of DEGs with significant differences revealed that they are involved in critical biological processes and molecular pathways, such as myeloid cell differentiation, peptidyl-lysine modification, signaling pathway of MyD88-dependent Toll-like receptor, and cell-cell adhesion.	Lysine	189-195	MYD88 innate immune signal transduction adaptor	Homo sapiens	231-236
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	Sp7 transcription factor	Homo sapiens	264-271
34018352-4	2021	The lysine-specific histone demethylase (LSD) family containing Tower domain and the histone demethylase family containing Jumonji C (JmjC) domain regulate the expression of various osteogenic-related genes, including Runt-related transcription factor 2 ( RUNX2), osterix ( OSX), osteocalcin ( OCN), to mediate MSCs osteogenic differentiation.	Lysine	4-10	Sp7 transcription factor	Homo sapiens	274-277
33661764-3	2021	Mechanistically, ELNAT1 induced UBC9 overexpression to catalyze the SUMOylation of hnRNPA1 at lysine-113 residue, which mediated the recognition of ELNAT1 by endosomal sorting complex required for transport (ESCRT) and facilitated their packaging into EVs.	Lysine	94-100	ubiquitin conjugating enzyme E2 I	Homo sapiens	32-36
32647127-5	2020	We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.	Lysine	17-23	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	59-65
32647127-5	2020	We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.	Lysine	17-23	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	118-124
32933054-8	2020	In addition, several lysines in the transmembrane domain and the proximal N-terminal region were labeled by NMM, raising the possibility that lysines are also key targets for electrophilic activation of hTRPA1.	Lysine	21-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	203-209
32933054-8	2020	In addition, several lysines in the transmembrane domain and the proximal N-terminal region were labeled by NMM, raising the possibility that lysines are also key targets for electrophilic activation of hTRPA1.	Lysine	142-149	transient receptor potential cation channel subfamily A member 1	Homo sapiens	203-209
33661764-3	2021	Mechanistically, ELNAT1 induced UBC9 overexpression to catalyze the SUMOylation of hnRNPA1 at lysine-113 residue, which mediated the recognition of ELNAT1 by endosomal sorting complex required for transport (ESCRT) and facilitated their packaging into EVs.	Lysine	94-100	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	83-90
33565211-2	2021	Increasing evidence suggests that variants of histone lysine methyltransferases including KMT5A are associated with neurodevelopmental disorders.	Lysine	54-60	lysine methyltransferase 5A	Homo sapiens	90-95
32787081-2	2020	In the current work, we proposed a hybrid strategy by incorporating pharmacophores that bind to the acetylated lysine binding pocket of BET proteins with a typical kinase hinge binder to generate novel polypharmacological inhibitors of BET and kinases.	Lysine	111-117	delta/notch like EGF repeat containing	Homo sapiens	136-139
32787081-2	2020	In the current work, we proposed a hybrid strategy by incorporating pharmacophores that bind to the acetylated lysine binding pocket of BET proteins with a typical kinase hinge binder to generate novel polypharmacological inhibitors of BET and kinases.	Lysine	111-117	delta/notch like EGF repeat containing	Homo sapiens	236-239
32198816-0	2020	Yin Yang-1 suppresses CD40 ligand-CD40 signaling mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter.	Lysine	191-197	CD40 molecule	Homo sapiens	22-26
32198816-0	2020	Yin Yang-1 suppresses CD40 ligand-CD40 signaling mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter.	Lysine	191-197	CD40 molecule	Homo sapiens	34-38
33279621-0	2021	Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.	Lysine	0-6	killer cell lectin like receptor K1	Homo sapiens	22-27
32894463-8	2020	Here, the crucial role of the ubiquitin lysine residue K27 in the process of histone H2A monoubiquitination mediated by the ubiquitin ligase RNF168 has been showed.	Lysine	40-46	keratin 27	Homo sapiens	55-58
32894463-8	2020	Here, the crucial role of the ubiquitin lysine residue K27 in the process of histone H2A monoubiquitination mediated by the ubiquitin ligase RNF168 has been showed.	Lysine	40-46	ring finger protein 168	Homo sapiens	141-147
32908002-2	2020	Here, we report that increased amounts of histone 3 lysine 4 demethylase KDM5A in tumors markedly improved response to the treatment with the programmed cell death protein 1 (PD-1) antibody in mouse cancer models.	Lysine	52-58	lysine (K)-specific demethylase 5A	Mus musculus	73-78
33279621-0	2021	Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.	Lysine	0-6	killer cell lectin like receptor K1	Homo sapiens	94-99
32894463-10	2020	The comparison of the turnover rate of the wild-type ubiquitin and its variant with a single functional lysine residue K27 suggests an important role of the ubiquitin deposition as a covalent conjugate with histone H2A in terms of the stability of the entire ubiquitinome.	Lysine	104-110	keratin 27	Homo sapiens	119-122
32888405-4	2020	Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA.	Lysine	0-6	SMAD family member 2	Homo sapiens	112-127
33279621-4	2021	Here, we showed that the shedding of the mouse NKG2D ligand Rae-1 can be prevented by two critical acetyltransferases, GCN5 and PCAF, which acetylate the lysine residues of Rae-1 to avoid shedding both in vitro and in vivo.	Lysine	154-160	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	47-52
33164644-15	2021	Besides, lysine (K) residues K31, K52, K83, and K265 of KLF5 were verified to be crucial to WWP2-mediated KLF5 transactivation.	Lysine	9-15	Kruppel-like factor 5	Mus musculus	56-60
32445435-0	2020	ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.	Lysine	85-91	arrestin, beta 1	Mus musculus	0-5
32445435-7	2020	Mechanistically, ARRB1 directly interacts with ASK1 in hepatocytes and inhibits its TRAF6-mediated Lysine 6-linked polyubiquitination, which then prevents the activation of ASK1 and its downstream signalling pathway during hepatic I/R injury.	Lysine	99-105	arrestin, beta 1	Mus musculus	17-22
32473242-1	2020	The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9, and upregulation of SETDB1 is associated with poor prognosis in cancer patients.	Lysine	94-100	PR/SET domain 9	Homo sapiens	4-29
33164644-15	2021	Besides, lysine (K) residues K31, K52, K83, and K265 of KLF5 were verified to be crucial to WWP2-mediated KLF5 transactivation.	Lysine	9-15	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	92-96
33164644-15	2021	Besides, lysine (K) residues K31, K52, K83, and K265 of KLF5 were verified to be crucial to WWP2-mediated KLF5 transactivation.	Lysine	9-15	Kruppel-like factor 5	Mus musculus	106-110
32333122-0	2020	The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset.	Lysine	23-25	glutamate receptor, metabotropic 3	Mus musculus	4-11
33674747-7	2021	We also show that LY6K-AS regulates the levels of histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of kinetochore members.	Lysine	61-67	long intergenic non-protein coding RNA 2605	Homo sapiens	23-25
32333122-0	2020	The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset.	Lysine	114-116	glutamate receptor, metabotropic 3	Mus musculus	4-11
32333122-2	2020	We have obtained these benefits with the mGlu2-positive allosteric modulator (PAM) LY-487,379 and the mGlu2/3 orthosteric agonist (OA) LY-354,740 in experiments conducted in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset.	Lysine	135-137	glutamate receptor, metabotropic 3	Mus musculus	102-109
32687671-8	2020	In response to agrin stimulation, APC2 negatively regulates AChR clustering by promoting the ubiquitination of DOK7 at lysine 243 for its proteolytic degradation, which relies on MuSK kinase activity and the phosphorylation of tyrosine 106 in DOK7.	Lysine	119-125	docking protein 7	Homo sapiens	111-115
33867840-2	2021	We have previously demonstrated that MnSOD lysine-68 (K68) acetylation (K68-Ac) leads to a change in function from a superoxide-scavenging homotetramer to a peroxidase-directed monomer.	Lysine	43-49	superoxide dismutase 2	Homo sapiens	37-42
32817552-7	2020	Mechanistically, KAT5 catalyzed acetylation of cGAS at multiple lysine residues in its N-terminal domain, which promoted its DNA-binding ability.	Lysine	64-70	K(lysine) acetyltransferase 5	Mus musculus	17-21
32661120-4	2020	In humans, MOF (hMOF), a member of the MYST family of HATs, acetylate histone H4 at lysine 16 (H4K16ac).	Lysine	84-90	lysine acetyltransferase 8	Homo sapiens	11-14
32661120-4	2020	In humans, MOF (hMOF), a member of the MYST family of HATs, acetylate histone H4 at lysine 16 (H4K16ac).	Lysine	84-90	lysine acetyltransferase 8	Homo sapiens	16-20
32491201-8	2020	The function and localization of Svl3 are significantly disrupted by the loss of this lysine-rich region; however, its localization is not completely abolished by the mutation because another localization signal enables appropriate transport.	Lysine	86-92	Svl3p	Saccharomyces cerevisiae S288C	33-37
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Lysine	147-150	angiotensin converting enzyme 2	Homo sapiens	109-113
33491560-1	2021	With No Lysine (K) kinase 4 (WNK4) belongs to a serine-threonine kinase family characterized by the atypical positioning of its catalytic lysine.	Lysine	138-144	WNK lysine deficient protein kinase 4	Mus musculus	29-33
32636834-8	2020	We have also found lysine residues in FOXP3 required for MDM2-mediated ubiquitination.	Lysine	19-25	forkhead box P3	Homo sapiens	38-43
32416090-0	2020	Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9.	Lysine	121-127	lamin B2	Homo sapiens	0-8
33082516-8	2021	Besides, lysine residue 10 and 65 of CIB1 is the ubiquitinated site of CIB1.	Lysine	9-15	calcium and integrin binding 1	Homo sapiens	37-41
32561529-4	2020	ATF3 was highly induced by combined PDI and HDACi treatment as a result of increased acetylation of key histone lysine residues (H3K27-ac, H3K18-ac) flanking the ATF3 promoter region.	Lysine	112-118	prolyl 4-hydroxylase subunit beta	Homo sapiens	36-39
33082516-8	2021	Besides, lysine residue 10 and 65 of CIB1 is the ubiquitinated site of CIB1.	Lysine	9-15	calcium and integrin binding 1	Homo sapiens	71-75
32861999-2	2020	We have previously found that AMPARs are subject to lysine acetylation, resulting in higher AMPAR stability and protein accumulation.	Lysine	52-58	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	30-35
32396165-3	2020	GCN5 was previously shown to acetylate lysine 14 of histone 3 (H3K14ac) in the promoter regions of its target genes even though GCN5 binding did not systematically correlate with gene activation.	Lysine	39-45	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	0-4
32970364-4	2021	Ubiquitin ligases RGLG1 and RGLG2 ubiquitinated MAPKKK18 at lysine residue K32 and K154, and promoted its degradation.	Lysine	60-66	RING domain ligase2	Arabidopsis thaliana	28-33
32850975-5	2020	The inhibition of SET8, a histone H4 lysine 20 (H4K20) monomethyltransferase, by UNC0379 markedly suppressed the expression of alpha-smooth muscle actin (SMA) and ED-A-fibronectin in myofibroblasts.	Lysine	37-43	lysine methyltransferase 5A	Homo sapiens	18-22
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	10-16	lysine demethylase 5C	Homo sapiens	49-54
33609736-0	2021	The Histone H3 Lysine 9 Methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.	Lysine	15-21	euchromatic histone methyltransferase 1	Mus musculus	46-49
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	93-99	lysine demethylase 5C	Homo sapiens	49-54
32553594-6	2020	At the molecular level, CR-CYLD overexpression enhanced PO-induced increases in poly-ubiquitinated proteins marked by lysine (K)48-linked ubiquitin chains and autophagic vacuoles containing undegraded contents while suppressing autophagic flux.	Lysine	118-124	CYLD lysine 63 deubiquitinase	Mus musculus	24-31
33609736-1	2021	The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream histone H3 lysine 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus.	Lysine	39-45	euchromatic histone methyltransferase 1	Mus musculus	4-24
32563459-0	2020	Arabidopsis UBC22, an E2 able to catalyze lysine-11 specific ubiquitin linkage formation, has multiple functions in plant growth and immunity.	Lysine	42-48	ubiquitin-conjugating enzyme 22	Arabidopsis thaliana	12-17
32545209-3	2020	Naked pDNA and a ternary complex, consisting of pDNA, dendrigraft poly-l-lysine (DGL), and gamma-polyglutamic acid (gamma-PGA), both showed strong gene expression in the lungs after inhalation.	Lysine	66-79	naked	Mus musculus	0-5
33609736-1	2021	The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream histone H3 lysine 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus.	Lysine	39-45	euchromatic histone methyltransferase 1	Mus musculus	26-29
33609736-1	2021	The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream histone H3 lysine 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus.	Lysine	100-106	euchromatic histone methyltransferase 1	Mus musculus	4-24
32597847-5	2020	Lysine 306 (K306) ubiquitylation in EYFP-CENP-A K124R was successfully identified, which corresponds to lysine 56 (K56) in CENP-A through mass spectrometry analysis.	Lysine	104-110	centromere protein A	Homo sapiens	41-47
33609736-1	2021	The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream histone H3 lysine 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus.	Lysine	100-106	euchromatic histone methyltransferase 1	Mus musculus	26-29
32597847-5	2020	Lysine 306 (K306) ubiquitylation in EYFP-CENP-A K124R was successfully identified, which corresponds to lysine 56 (K56) in CENP-A through mass spectrometry analysis.	Lysine	104-110	centromere protein A	Homo sapiens	123-129
33567897-2	2021	Protein lysine malonylation (MaK) is a posttranslational modification (PTM) that has been shown to play an important role during aging and obesity.	Lysine	8-14	male germ cell-associated kinase	Mus musculus	29-32
32401531-0	2020	UbcH5 interacts with substrates to participate in lysine selection with the E3 ubiquitin ligase CHIP.	Lysine	50-56	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-5
32401531-5	2020	We show that UbcH5 selects substrate lysine residues independent of CHIP, and CHIP participates in lysine selection by fine-tuning the subset of substrate lysines that are ubiquitinated.	Lysine	37-43	ubiquitin conjugating enzyme E2 D1	Homo sapiens	13-18
32765954-9	2020	Deregulation of p300, in response to prohypertrophic and profibrogenic stress signals, is associated with increased recruitment of p300 to several genes including transcription factors, increased acetylation of specific lysines in histones and transcription factors, altered chromatin organization, and increased hypertrophic and fibrogenic gene expression.	Lysine	220-227	E1A binding protein p300	Homo sapiens	16-20
32765954-9	2020	Deregulation of p300, in response to prohypertrophic and profibrogenic stress signals, is associated with increased recruitment of p300 to several genes including transcription factors, increased acetylation of specific lysines in histones and transcription factors, altered chromatin organization, and increased hypertrophic and fibrogenic gene expression.	Lysine	220-227	E1A binding protein p300	Homo sapiens	131-135
32401531-5	2020	We show that UbcH5 selects substrate lysine residues independent of CHIP, and CHIP participates in lysine selection by fine-tuning the subset of substrate lysines that are ubiquitinated.	Lysine	155-162	ubiquitin conjugating enzyme E2 D1	Homo sapiens	13-18
32401531-6	2020	We also identify lysine 128 near the C-terminus of UbcH5 as a critical residue for efficient ubiquitin transfer by UbcH5 in both the presence and absence of CHIP.	Lysine	17-23	ubiquitin conjugating enzyme E2 D1	Homo sapiens	51-56
33541373-10	2021	SUZ12 is a member of the polycomb repressor complex 2 that suppresses gene expression through methylating histone H3 at lysine 27.	Lysine	120-126	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	0-5
32527012-3	2020	STRAP is acetylated at lysines 147, 148, and 156 by the acetyltransferases CREB-binding protein (CBP) and that the acetylation is reversed by the deacetylase sirtuin7 (SIRT7).	Lysine	23-30	serine/threonine kinase receptor associated protein	Homo sapiens	0-5
32527012-4	2020	Hypo- or hyperacetylation mutations of STRAP at lysines 147, 148, and 156 (3KR or 3KQ) influence its activation and stabilization of p53.	Lysine	48-55	serine/threonine kinase receptor associated protein	Homo sapiens	39-44
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	141-144	angiotensin converting enzyme 2	Homo sapiens	187-191
32679077-4	2020	OTUD3 directly hydrolyzes lysine 63 (Lys63)-linked polyubiquitination of MAVS and thus shuts off innate antiviral immune response.	Lysine	26-32	OTU domain containing 3	Mus musculus	0-5
33185915-4	2021	The acetyl-histone H4 and trimethylated histone H3-lysine 4, two post translational modifications of histones, occupying on the TSPY1 promoter, faciliated the TSPY1 expression in PCa cells.	Lysine	51-57	testis specific protein Y-linked 1	Homo sapiens	128-133
32416562-5	2020	NF-kB translocation may occur due to acetylation and phosphorylation LYS 310 and SER311 amino acids in chain A of the p65 subunit in response to IKK-alpha/beta activity.	Lysine	69-72	RELA proto-oncogene, NF-kB subunit	Homo sapiens	118-121
32416562-6	2020	Therefore, there are two ways to inhibit the NF-kB translocation, either directly blocking the active sites of IKK-alpha/beta enzymes or protecting the LYS 310 and SER311 of p65 subunit from acetylation and phosphorylation.	Lysine	152-155	RELA proto-oncogene, NF-kB subunit	Homo sapiens	174-177
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	244-247	angiotensin converting enzyme 2	Homo sapiens	187-191
33185915-4	2021	The acetyl-histone H4 and trimethylated histone H3-lysine 4, two post translational modifications of histones, occupying on the TSPY1 promoter, faciliated the TSPY1 expression in PCa cells.	Lysine	51-57	testis specific protein Y-linked 1	Homo sapiens	159-164
33513265-6	2021	Our further studies identified Lys313 as a major ubiquitin acceptor lysine of IRF3 induced by MID1.	Lysine	68-74	interferon regulatory factor 3	Homo sapiens	78-82
32301534-0	2020	SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation.	Lysine	90-96	sirtuin 5	Mus musculus	0-5
32301534-5	2020	SIRT5-catalyzed desuccinylation of MAVS at Lysine 7 diminishes the formation of MAVS aggregation after viral infection, resulting in the inhibition of MAVS activation and leading to the impairment of type I IFN production and antiviral gene expression.	Lysine	43-49	sirtuin 5	Mus musculus	0-5
32453962-5	2021	Mechanistically, we demonstrated that STAMBP/AMSH (STAM-binding protein) promotes the stabilization of ULK1 by removing its lysine 48 (K48)-linked ubiquitination, whereas OTUD7B mediates the degradation of PIK3 C3 by enhancing its K48-linked ubiquitination, thus positively or negatively affects autophagy flux, respectively.	Lysine	124-130	unc-51 like autophagy activating kinase 1	Homo sapiens	103-107
32378752-6	2020	By binding to a component of the epigenetic modification complex enhancer of zeste homolog 2 (EZH2), ANRIL could maintain lysine residue 27 of histone 3 (H3K27me3) levels in the promoter of ERBB receptor feedback inhibitor 1 (ERRFI1), which is a tumour suppressor gene in CCA.	Lysine	122-128	ERBB receptor feedback inhibitor 1	Homo sapiens	190-224
32572214-2	2020	Here, we show that the substrate specificity of the Arabidopsis histone demethylase JMJ16 is broadened from Lys 4 of histone H3 (H3K4) alone in somatic cells to both H3K4 and H3K9 when it binds to the meiocyte-specific histone reader MMD1.	Lysine	108-111	RING/FYVE/PHD zinc finger superfamily protein	Arabidopsis thaliana	234-238
32439949-10	2020	High glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8.	Lysine	54-60	lysine methyltransferase 5A	Homo sapiens	111-115
33532796-3	2021	The glutamate (E) to Lysine (K) substitution at position 484 (E484K) in the receptor binding domain (RBD) of the spike protein is present in the rapidly spreading variants of concern belonging to the B.1.351 and P.1 lineages.	Lysine	21-27	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	113-118
33510349-5	2021	Histone H3, phosphorylated at serine 10 and acetylated at lysine 14 (H3S10pK14Ac), a MSK1/2 target, showed increased abundance only in LgA-H rats.	Lysine	58-64	ribosomal protein S6 kinase A5	Rattus norvegicus	85-91
32424115-2	2020	RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromatin.	Lysine	48-54	ring finger protein 168	Homo sapiens	0-6
32424115-2	2020	RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromatin.	Lysine	48-54	H2A clustered histone 18	Homo sapiens	17-20
32424115-2	2020	RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromatin.	Lysine	48-54	H2A.X variant histone	Homo sapiens	25-29
32424115-3	2020	Here, we report that RNF168 ubiquitinates the non-canonical H2A variants H2AZ and macroH2A1/2 at the divergent N-terminal tail lysine residue.	Lysine	127-133	ring finger protein 168	Homo sapiens	21-27
32424115-6	2020	Our results reveal a juxtaposed bipartite electrostatic interaction utilized by the nucleosome to direct RNF168 orientation towards the target lysine residues in proximity to the H2A alpha1-extension helix, which plays an important role in the DDR pathway.	Lysine	143-149	ring finger protein 168	Homo sapiens	105-111
32424115-6	2020	Our results reveal a juxtaposed bipartite electrostatic interaction utilized by the nucleosome to direct RNF168 orientation towards the target lysine residues in proximity to the H2A alpha1-extension helix, which plays an important role in the DDR pathway.	Lysine	143-149	H2A clustered histone 18	Homo sapiens	179-182
32452419-3	2020	Subsequently, we verified that all the mutants at the residue 185, regardless of amino acid size (including Cys and Ser) and charge (including Glu and Lys), impaired nsp4 catalytic activity.	Lysine	151-154	serine protease 57	Homo sapiens	166-170
32584788-4	2020	Specifically, SIRT6 mono-ADP ribosylates the lysine demethylase JHDM1A/KDM2A leading to rapid displacement of KDM2A from chromatin, resulting in increased H3K36me2 levels.	Lysine	45-51	sirtuin 6	Homo sapiens	14-19
33501915-6	2021	Among cells that consumed lysine and released hypoxanthine, ecm21 mutations repeatedly arose.	Lysine	26-32	Ecm21p	Saccharomyces cerevisiae S288C	60-65
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	Kruppel-like factor 6	Rattus norvegicus	107-111
32404892-5	2020	Importantly, our results showed that USP38 was a specific deubiquitinase of histone deacetylase 3 (HDAC3), which cleaved the lysine 63 ubiquitin chain.	Lysine	125-131	ubiquitin specific peptidase 38	Homo sapiens	37-42
32404892-5	2020	Importantly, our results showed that USP38 was a specific deubiquitinase of histone deacetylase 3 (HDAC3), which cleaved the lysine 63 ubiquitin chain.	Lysine	125-131	histone deacetylase 3	Homo sapiens	76-97
32404892-5	2020	Importantly, our results showed that USP38 was a specific deubiquitinase of histone deacetylase 3 (HDAC3), which cleaved the lysine 63 ubiquitin chain.	Lysine	125-131	histone deacetylase 3	Homo sapiens	99-104
32685011-9	2020	Moreover, KLF5 acetylation at lysine 369 mediates DTX resistance in vitro and in vivo.	Lysine	30-36	Kruppel like factor 5	Homo sapiens	10-14
33501915-7	2021	ecm21 is self-serving, improving self"s growth rate in limiting lysine.	Lysine	64-70	Ecm21p	Saccharomyces cerevisiae S288C	0-5
33501915-8	2021	ecm21 is also partner-serving, increasing hypoxanthine release rate per lysine consumption and the steady state growth rate of partner.	Lysine	72-78	Ecm21p	Saccharomyces cerevisiae S288C	0-5
33501915-9	2021	ecm21 also arose in monocultures evolving in lysine-limited chemostats.	Lysine	45-51	Ecm21p	Saccharomyces cerevisiae S288C	0-5
33506343-7	2021	Mechanismly, SETD4 knockout inhibited sets of monomethylases and dimethylases for histone lysine, along with significant changes in some factors including Nkx2.5, Gata4, Gli2, Grem2, E2f7, Map7, Nr2f2 and Shox2 that associated with stem cell biology.	Lysine	90-96	SET domain containing 4	Mus musculus	13-18
32552847-10	2020	Mechanistically, LAMP5-AS1 facilitated the methyltransferase activity of DOT1L by directly binding its Lys-rich region of catalytic domain, thus promoting the global patterns of H3K79 dimethylation and trimethylation in cells.	Lysine	103-106	prostaglandin D2 receptor	Homo sapiens	23-26
32597847-4	2020	Here we describe mass spectrometry analysis to identify ubiquitylation of EYFP-CENP-A K124R mutant suggesting that ubiquitylation at a different lysine is induced because of the EYFP tagging in the CENP-A K124R mutant protein.	Lysine	145-151	centromere protein A	Homo sapiens	79-85
32597847-4	2020	Here we describe mass spectrometry analysis to identify ubiquitylation of EYFP-CENP-A K124R mutant suggesting that ubiquitylation at a different lysine is induced because of the EYFP tagging in the CENP-A K124R mutant protein.	Lysine	145-151	centromere protein A	Homo sapiens	198-204
32597847-5	2020	Lysine 306 (K306) ubiquitylation in EYFP-CENP-A K124R was successfully identified, which corresponds to lysine 56 (K56) in CENP-A through mass spectrometry analysis.	Lysine	0-6	centromere protein A	Homo sapiens	41-47
32597847-5	2020	Lysine 306 (K306) ubiquitylation in EYFP-CENP-A K124R was successfully identified, which corresponds to lysine 56 (K56) in CENP-A through mass spectrometry analysis.	Lysine	0-6	centromere protein A	Homo sapiens	123-129
32528826-1	2020	Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic cascade.	Lysine	111-117	NEDD8 ubiquitin like modifier	Homo sapiens	100-105
32061777-8	2020	Likewise, mutation of four lysine residues within MRTF-A rendered it more potent in terms of activating the collagen promoters but unresponsive to SIRT1.	Lysine	27-33	myocardin related transcription factor A	Homo sapiens	50-56
33498219-3	2021	WNK4 (with-no-lysine 4) regulates the NCC/NKCC2 through SAPK (Ste20-related proline-alanine-rich kinase)/OSR1 (oxidative stress responsive).	Lysine	14-20	WNK lysine deficient protein kinase 4	Mus musculus	0-4
32240951-2	2020	We used quantitative proteomics to compare the seven lysine-linked ubiquitin chains between wild-type yeast and its 20 DUB-deletion strains, which may reflect the linkage specificity of DUBs in vivo.	Lysine	53-59	ubiquitin	Saccharomyces cerevisiae S288C	67-76
32518592-8	2020	The microdeletion involves 24 OMIM genes including ASH1L (also known as KMT2H and encoding a histone lysine methyltransferase).	Lysine	101-107	ASH1 like histone lysine methyltransferase	Homo sapiens	51-56
33107080-6	2021	PCR-based site mutation of specific GSK3beta lysine residues was used to confirm which lysine residues function in oocyte meiosis.	Lysine	45-51	glycogen synthase kinase 3 alpha	Mus musculus	36-44
32155529-0	2020	Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).	Lysine	75-81	lysine demethylase 5B	Homo sapiens	107-112
32155529-0	2020	Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).	Lysine	75-81	lysine demethylase 5B	Homo sapiens	113-120
33107080-6	2021	PCR-based site mutation of specific GSK3beta lysine residues was used to confirm which lysine residues function in oocyte meiosis.	Lysine	87-93	glycogen synthase kinase 3 alpha	Mus musculus	36-44
31742425-1	2020	The purpose of this study was to characterize the expression of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a membrane-bound homodimeric enzyme that specifically hydroxylates lysine in the telopeptide of procollagens, and assess the clinical significance of PLOD2 in colorectal cancer (CRC).	Lysine	76-82	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	116-121
33107080-11	2021	By constructing site-specific mutants, we further revealed that acetylation state of lysine (K) 15 on GSK3beta is essential for spindle assembly and chromosome alignment during oocyte meiosis.	Lysine	85-91	glycogen synthase kinase 3 alpha	Mus musculus	102-110
31742425-1	2020	The purpose of this study was to characterize the expression of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a membrane-bound homodimeric enzyme that specifically hydroxylates lysine in the telopeptide of procollagens, and assess the clinical significance of PLOD2 in colorectal cancer (CRC).	Lysine	76-82	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	274-279
32081014-0	2020	Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.	Lysine	15-21	histone acetyltransferase 1	Homo sapiens	0-4
33360835-7	2021	Mutagenesis of selected individual lysine residues identified K394, but not K951, as a key residue for SUMO-1-mediated increase in CaV2.2 Ca2+ current density.	Lysine	35-41	small ubiquitin like modifier 1	Homo sapiens	103-109
32111629-6	2020	In this study, we have identified sumoylation sites lysine (K) 215/216 in the C-terminus of Cse4 and shown that sumoylation of Cse4 K215/216 facilitates its genome-wide deposition into chromatin when overexpressed.	Lysine	52-58	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	92-96
32111629-6	2020	In this study, we have identified sumoylation sites lysine (K) 215/216 in the C-terminus of Cse4 and shown that sumoylation of Cse4 K215/216 facilitates its genome-wide deposition into chromatin when overexpressed.	Lysine	52-58	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	127-131
32478681-7	2020	Parkin interacted with PHGDH and ubiquitinated PHGDH at lysine 330, leading to PHGDH degradation to suppress serine synthesis.	Lysine	56-62	phosphoglycerate dehydrogenase	Homo sapiens	47-52
33378328-10	2020	Gcn4 directly binds promoter-regions and transcribes a subset of metabolic genes, particularly driving lysine and arginine biosynthesis.	Lysine	103-109	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	0-4
32478681-7	2020	Parkin interacted with PHGDH and ubiquitinated PHGDH at lysine 330, leading to PHGDH degradation to suppress serine synthesis.	Lysine	56-62	phosphoglycerate dehydrogenase	Homo sapiens	47-52
31099089-7	2020	Consistently, chromatin immunoprecipitation results confirm that PPD2 and LHP1 are co-enriched at the promoter region of their targets such as D3-TYPE CYCLINS and HIGH MOBILITY GROUP A, which are up-regulated in ppd2, lhp1 and ppd2 lhp1 mutants, and that PPDs mediate repressive histone 3 lysine-27 trimethylation at these loci.	Lysine	289-295	TIFY domain/Divergent CCT motif family protein	Arabidopsis thaliana	65-69
32178723-1	2020	BACKGROUND: SETD8 is the sole methyltransferase capable of mono-methylating histone H4, lysine 20.	Lysine	88-94	lysine methyltransferase 5A	Homo sapiens	12-17
33378328-11	2020	Gcn4 also globally represses lysine and arginine enriched transcripts, which include genes encoding the translation machinery.	Lysine	29-35	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	0-4
33378328-12	2020	The Gcn4 dependent lysine and arginine supply thereby maintains the synthesis of the translation machinery.	Lysine	19-25	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	4-8
33008594-0	2020	Lysine is required for growth factor-induced mTORC1 activation.	Lysine	0-6	CREB regulated transcription coactivator 1	Mus musculus	45-51
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	119-125	SET domain containing 6, protein lysine methyltransferase	Rattus norvegicus	39-44
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	K(lysine) acetyltransferase 2B	Mus musculus	33-37
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	K(lysine) acetyltransferase 2B	Mus musculus	75-79
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	119-125	SET domain containing 6, protein lysine methyltransferase	Rattus norvegicus	237-242
33008594-3	2020	Here, we investigated the effect of lysine on mTORC1 activity in non-small cell lung cancer (NSCLC) cells.	Lysine	36-42	CREB regulated transcription coactivator 1	Mus musculus	46-52
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	178-184	SET domain containing 6, protein lysine methyltransferase	Rattus norvegicus	39-44
32471474-1	2020	BACKGROUND: The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear.	Lysine	26-32	lysine methyltransferase 2C	Homo sapiens	56-61
33008594-4	2020	Lysine deprivation suppressed mTORC1 activity and lysine replenishment restored the decreased mTORC1 activity in lysine-deprived cells.	Lysine	0-6	CREB regulated transcription coactivator 1	Mus musculus	30-36
33008594-4	2020	Lysine deprivation suppressed mTORC1 activity and lysine replenishment restored the decreased mTORC1 activity in lysine-deprived cells.	Lysine	50-56	CREB regulated transcription coactivator 1	Mus musculus	94-100
33008594-4	2020	Lysine deprivation suppressed mTORC1 activity and lysine replenishment restored the decreased mTORC1 activity in lysine-deprived cells.	Lysine	113-119	CREB regulated transcription coactivator 1	Mus musculus	94-100
32024693-6	2020	ChIP results indicated increased enrichment of histone 3 at lysine 9 dimethylation, a G9a-catalyzed repressive histone mark, at the promoter regions of the CB1R genes.	Lysine	60-66	cannabinoid receptor 1 (brain)	Mus musculus	156-160
33008594-7	2020	General control nonderepressible 2 and AMP-activated protein kinase were involved in lysine deprivation-mediated inhibition of mTORC1.	Lysine	85-91	CREB regulated transcription coactivator 1	Mus musculus	127-133
33008594-8	2020	Taken together, these results suggest that lysine might play role in the regulation of mTORC1 activation in NSCLC cells.	Lysine	43-49	CREB regulated transcription coactivator 1	Mus musculus	87-93
33392152-2	2020	It plays a key role during the elongation of polypeptide chains, and its activity is critically dependent on hypusination, a post-translational modification of a specific lysine residue through two consecutive enzymatic steps carried out by deoxyhypusine synthase (DHS), with spermidine as substrate, and deoxyhypusine hydroxylase (DOHH).	Lysine	171-177	Glu-tRNA(Gln) amidotransferase subunit GatD	Saccharolobus solfataricus	241-263
32161353-1	2020	The expression of lysine methyltransferase SET8, which is involved in carcinogenesis of many types of human cancers through monomethylation of histone H4 lysine 20 (H4K20), is associated with the prognosis of hepatocellular carcinoma (HCC).	Lysine	18-24	lysine methyltransferase 5A	Homo sapiens	43-47
32596350-6	2020	lncRNA EZR-AS1 was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription.	Lysine	105-111	SET and MYND domain containing 3	Homo sapiens	42-82
32596350-6	2020	lncRNA EZR-AS1 was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription.	Lysine	105-111	SET and MYND domain containing 3	Homo sapiens	84-89
33299050-3	2020	Here, we identify new unnatural lysine analogues as substrates for human methyltransferases SETD7, SETD8, G9a and GLP.	Lysine	32-38	lysine methyltransferase 5A	Homo sapiens	99-104
32243810-4	2020	We show that IFITM3 ubiquitination at lysine 24 is crucial for VCP binding, trafficking, turnover, and engagement with incoming virus particles.	Lysine	38-44	valosin containing protein	Homo sapiens	63-66
32161353-1	2020	The expression of lysine methyltransferase SET8, which is involved in carcinogenesis of many types of human cancers through monomethylation of histone H4 lysine 20 (H4K20), is associated with the prognosis of hepatocellular carcinoma (HCC).	Lysine	154-160	lysine methyltransferase 5A	Homo sapiens	43-47
33299050-6	2020	In contrast to monomethyltransferase SETD7, SETD8 exhibits high specificity for both lysine analogues.	Lysine	85-91	lysine methyltransferase 5A	Homo sapiens	44-49
33457194-0	2020	p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1.	Lysine	15-21	E1A binding protein p300	Homo sapiens	0-4
32164275-4	2020	We further demonstrated an increased mono-methylation of histone H3 at lysine 4 (H3K4me1) modification at this enhancer concomitant with a topological interaction between sub-regions of this enhancer and with promoter of WNT3A gene.	Lysine	71-77	Wnt family member 3A	Homo sapiens	221-226
32432549-6	2020	The DOM-A complex, instead, functions as an ATP-independent histone acetyltransferase complex similar to the yeast NuA4, targeting lysine 12 of histone H4.	Lysine	131-137	histone H4	Saccharomyces cerevisiae S288C	144-154
33457194-0	2020	p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1.	Lysine	15-21	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	106-148
33457194-6	2020	Moreover, our results indicate that HNRNPA1 could be regulated by p300 through p300-mediated lysine crotonylation.	Lysine	93-99	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	36-43
32671208-2	2020	Here, we have explored the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.	Lysine	57-63	lysine acetyltransferase 8	Homo sapiens	85-88
31512982-8	2020	We also found that the acetylation state of lysine 9 of H3 was altered in the strains deficient in Nut1 HAT and Hos1 HDAC in the genes up-regulated during osmotic stress in an Msn2/Msn4-independent manner, while lysine 9 acetylation of H3 varied in the strains deficient in Sas2 HAT and Rpd3 HDAC for the Msn2/Msn4-dependent induced genes.	Lysine	44-50	histone deacetylase 3	Homo sapiens	287-291
33457194-6	2020	Moreover, our results indicate that HNRNPA1 could be regulated by p300 through p300-mediated lysine crotonylation.	Lysine	93-99	E1A binding protein p300	Homo sapiens	66-70
33457194-6	2020	Moreover, our results indicate that HNRNPA1 could be regulated by p300 through p300-mediated lysine crotonylation.	Lysine	93-99	E1A binding protein p300	Homo sapiens	79-83
33457194-7	2020	Inhibition of p300 downregulated both the lysine crotonylation level and the HNRNPA1 expression.	Lysine	42-48	E1A binding protein p300	Homo sapiens	14-18
33457194-8	2020	And p300-mediated lysine crotonylation participates in the regulation of HNRNPA1 on HeLa cell proliferation, invasion, and migration.	Lysine	18-24	E1A binding protein p300	Homo sapiens	4-8
32425076-3	2020	DNA sequencing revealed a new point mutation (HBA2: c.49A>C) at codon 16, resulting in an amino acid substitution from lysine to glutamine.	Lysine	119-125	hemoglobin subunit alpha 2	Homo sapiens	46-50
32314924-1	2020	Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating gene transcription.	Lysine	75-81	transmembrane serine protease 11D	Homo sapiens	0-31
32314924-1	2020	Histone acetyltransferase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating gene transcription.	Lysine	75-81	E1A binding protein p300	Homo sapiens	32-36
33457194-8	2020	And p300-mediated lysine crotonylation participates in the regulation of HNRNPA1 on HeLa cell proliferation, invasion, and migration.	Lysine	18-24	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	73-80
33457194-9	2020	Collectively, our study uncovers that p300-mediated lysine crotonylation enhances expression of HNRNPA1 to promote the proliferation, invasion, and migration of HeLa cells.	Lysine	52-58	E1A binding protein p300	Homo sapiens	38-42
33457194-9	2020	Collectively, our study uncovers that p300-mediated lysine crotonylation enhances expression of HNRNPA1 to promote the proliferation, invasion, and migration of HeLa cells.	Lysine	52-58	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	96-103
32967969-10	2020	A mutant GCGR with all five intracellular lysines altered to arginines remains deubiquitinated, and shows augmented trafficking to Rab4a recycling endosomes compared with the WT, thus affirming the role of deubiquitination in GCGR recycling.	Lysine	42-49	glucagon receptor	Homo sapiens	9-13
32249212-0	2020	SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation.	Lysine	49-52	ubiquitin conjugating enzyme E2 I	Homo sapiens	73-77
32141264-10	2020	The levels of phosphorylated serine and acetylated lysine in peroxiredoxin-6 were significantly increased in the BECs following hydrogen peroxide treatment.	Lysine	51-57	peroxiredoxin 6	Homo sapiens	61-76
32094691-7	2020	We identify two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1"s RING domain.	Lysine	176-182	synoviolin 1	Homo sapiens	56-60
32094691-7	2020	We identify two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1"s RING domain.	Lysine	176-182	synoviolin 1	Homo sapiens	195-199
31996376-5	2020	Down syndrome critical region gene 6 (DSCR6), a RIPPLY family member that induces dorsal mesoderm by releasing repressive polycomb group proteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional and ventralizing activities by interfering with its lysine methylation.	Lysine	287-293	ripply transcriptional repressor 3 S homeolog	Xenopus laevis	0-36
31996376-5	2020	Down syndrome critical region gene 6 (DSCR6), a RIPPLY family member that induces dorsal mesoderm by releasing repressive polycomb group proteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional and ventralizing activities by interfering with its lysine methylation.	Lysine	287-293	ripply transcriptional repressor 3 S homeolog	Xenopus laevis	38-43
31996376-8	2020	Furthermore, interference with Ezh2 phosphorylation also prevented Stat3 lysine methylation and transcriptional activity.	Lysine	73-79	enhancer of zeste 2 polycomb repressive complex 2 subunit L homeolog	Xenopus laevis	31-35
32978260-2	2020	alphaM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of alphaM complement components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface glycans.	Lysine	115-121	complement C4B (Chido blood group)	Homo sapiens	189-192
32980952-1	2020	Cationic amino acid transporter 1 (Cat-1 alias Slc7a1) is a Na+-independent carrier system involved in transport and absorption of the cationic amino acids lysine, arginine, histidine, and ornithine and has also been shown to be indispensable in a large variety of biological processes.	Lysine	156-162	solute carrier family 7 member 1a	Danio rerio	47-53
31980531-2	2020	MALT1 activation requires its monoubiquitination on lysine 644 (K644) within the Ig3 domain, localized adjacent to the protease domain.	Lysine	52-58	MALT1 paracaspase	Homo sapiens	0-5
32814111-19	2020	Knockdown of lysine demethylases, or succinate supplementation, restored expression of LGR5 to SLC25A22-knockout CRC cells.	Lysine	13-19	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	87-91
31732298-5	2020	Notably, miR24-2 inhibits histone deacetylase HDAC3 through miR675, which promotes the acetylation of histone H4 at lysine 16.	Lysine	116-122	histone deacetylase 3	Homo sapiens	46-51
32310056-4	2020	However, the envelope protein contained Lys 84, which was specific to strains of genotype 5 viruses from South Korea.	Lysine	40-43	endogenous retrovirus group K member 6, envelope	Homo sapiens	13-29
32979659-3	2020	EP300 is a type 3 major lysine (K) acetyl transferase, and its aberrant activity is implicated in many human diseases.	Lysine	24-30	E1A binding protein p300	Homo sapiens	0-5
32338270-0	2020	Lysine inhibits apoptosis in satellite cells to govern skeletal muscle growth via the JAK2-STAT3 pathway.	Lysine	0-6	Janus kinase 2	Homo sapiens	86-90
32338270-6	2020	Interestingly, apoptosis was suppressed, and the JAK2-STAT3 pathway was reactivated after Lys re-supplementation.	Lysine	90-93	Janus kinase 2	Homo sapiens	49-53
32338270-8	2020	Moreover, the JAK2-STAT3 pathway was reactivated by Lys re-supplementation and suppressed cell apoptosis, and this effect was inhibited after treatment with Tyrphostin B42 (AG 490).	Lysine	52-55	Janus kinase 2	Homo sapiens	14-18
31830521-0	2020	Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-beta1/Smad3 pathway.	Lysine	0-6	transforming growth factor, beta 1	Mus musculus	88-97
31830521-0	2020	Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-beta1/Smad3 pathway.	Lysine	0-6	SMAD family member 3	Mus musculus	98-103
32338270-9	2020	In conclusion, we found that Lys inhibits apoptosis in SCs to govern skeletal muscle growth via the JAK2-STAT3 pathway.	Lysine	29-32	Janus kinase 2	Homo sapiens	100-104
33001399-4	2020	Furthermore, Gcdh-/- mice receiving low Lys and injected with LPS presented elevated MDA levels and decreased reduced glutathione (GSH) concentrations, glutathione peroxidase (GPx), and glutathione reductase (GR) activities in cerebral cortex.	Lysine	40-43	glutathione reductase	Mus musculus	186-207
32355204-0	2020	Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer.	Lysine	79-85	Wnt family member 3A	Homo sapiens	15-18
33001399-4	2020	Furthermore, Gcdh-/- mice receiving low Lys and injected with LPS presented elevated MDA levels and decreased reduced glutathione (GSH) concentrations, glutathione peroxidase (GPx), and glutathione reductase (GR) activities in cerebral cortex.	Lysine	40-43	glutathione reductase	Mus musculus	209-211
32174759-7	2020	Proteins and amino acids, such as lysine and methionine, in the diet trigger GLP-1 secretion from the chicken intestinal L cells.	Lysine	34-40	glucagon	Gallus gallus	77-82
32816380-5	2020	We report novel fragments which bind specifically to a lysine at the PPI interface of the p65 subunit-derived peptide of NF-kappaB with the adapter protein 14-3-3.	Lysine	55-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	90-93
32355204-6	2020	Interestingly, Wnt3a increases the level and nuclear translocation of Bcl-3, which binds directly to beta-catenin and enhances the acetylation of beta-catenin at lysine 49 (Ac-K49-beta-catenin) and transcriptional activity.	Lysine	162-168	Wnt family member 3A	Homo sapiens	15-20
33200028-4	2020	Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding.	Lysine	114-118	angiotensin converting enzyme 2	Homo sapiens	162-166
33223508-7	2020	Further mechanistic studies demonstrated that histone H3 lysine 36 trimethylation (H3K36me3) catalyzed by SETD2 interacted with the promoter of CXCL1 to regulate its transcription and downstream signaling pathways, contributing to tumorigenesis in vitro and in vivo.	Lysine	57-63	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	106-111
32275833-0	2020	mTORC1-mediated satellite cell differentiation is required for lysine-induced skeletal muscle growth.	Lysine	63-69	CREB regulated transcription coactivator 1	Mus musculus	0-6
33208180-2	2020	Tranexamic acid (TXA) reversibly blocks lysine binding sites on plasminogen molecules and inhibits plasmin formation.	Lysine	40-46	plasminogen	Homo sapiens	64-71
32275833-7	2020	Collectively, the results showed that mTORC1 pathway-mediated SC differentiation was required for Lys-promoted skeletal muscle growth.	Lysine	98-101	CREB regulated transcription coactivator 1	Mus musculus	38-44
32332759-4	2020	Upon DSB induction, SIRT1 translocates to the nucleus and deacetylates FOXL2 at lysine 124, leading to liberation of XRCC5 and XRCC6 from FOXL2 and formation of the Ku complex.	Lysine	80-86	X-ray repair cross complementing 5	Homo sapiens	117-122
32317327-6	2020	Mechanistically, RBMX binds to HIV-1 proviral DNA at the LTR downstream region and maintains the repressive trimethylation of histone H3 lysine 9 (H3K9me3), leading to a blockage of the recruitment of the positive transcription factor phosphorylated RNA polymerase II (RNA pol II) and consequential impediment of transcription elongation.	Lysine	137-143	RNA binding motif protein X-linked	Homo sapiens	17-21
31922564-2	2020	Our previous research showed that dietary lysine restriction compromised the growth performance of late-stage finishing pigs, which was associated with the changes in plasma concentrations of nutrient metabolites and hormone insulin-like growth factor 1 (IGF-1).	Lysine	42-48	insulin like growth factor 1	Sus scrofa	225-253
31922564-2	2020	Our previous research showed that dietary lysine restriction compromised the growth performance of late-stage finishing pigs, which was associated with the changes in plasma concentrations of nutrient metabolites and hormone insulin-like growth factor 1 (IGF-1).	Lysine	42-48	insulin like growth factor 1	Sus scrofa	255-260
33208464-5	2021	Co-immunoprecipitation demonstrated that M interacted with the full length or middle domain of ATP6V1A, which was dependent on the lysine residue at position 256 and the glutamic acid residue at position 279.	Lysine	131-137	ATPase H+ transporting V1 subunit A	Homo sapiens	95-102
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	21-27	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	60-70
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	21-27	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	121-131
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	103-109	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	60-70
32643178-7	2020	Moreover, it was demonstrated that the expression of seed dormancy-related genes was increased in hda19, suvh5 and hda19 suvh5 double mutant plants, which was associated with increased histone H3 acetylation (H3ac), but decreased histone H3 Lys 9 dimethylation (H3K9me2).	Lysine	241-244	histone deacetylase 1	Arabidopsis thaliana	98-103
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	103-109	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	121-131
31718142-2	2019	In this work, we rationally designed a furin-responsive radiotracer Acetyl-Arg-Val-Arg-Arg-Cys(StBu)-Lys(DOTA-68Ga)-CBT (CBT-68Ga) and demonstrated that coinjection of the radiotracer with its cold analogue CBT-Ga instructed the formation of 68Ga nanoparticles in furin-overexpressing MDA-MB-468 cancer cells, which significantly enhanced microPET imaging of the tumor in vivo.	Lysine	101-104	furin, paired basic amino acid cleaving enzyme	Homo sapiens	39-44
31718142-2	2019	In this work, we rationally designed a furin-responsive radiotracer Acetyl-Arg-Val-Arg-Arg-Cys(StBu)-Lys(DOTA-68Ga)-CBT (CBT-68Ga) and demonstrated that coinjection of the radiotracer with its cold analogue CBT-Ga instructed the formation of 68Ga nanoparticles in furin-overexpressing MDA-MB-468 cancer cells, which significantly enhanced microPET imaging of the tumor in vivo.	Lysine	101-104	furin, paired basic amino acid cleaving enzyme	Homo sapiens	264-269
32325818-6	2020	For the first time, we demonstrate that XIST accumulation in bovine embryos starts in nuclei of female morulae, but its colocalization with histone H3 lysine 27 trimethylation was first detected in day 7 blastocysts.	Lysine	151-157	XIST	Bos taurus	40-44
32643178-7	2020	Moreover, it was demonstrated that the expression of seed dormancy-related genes was increased in hda19, suvh5 and hda19 suvh5 double mutant plants, which was associated with increased histone H3 acetylation (H3ac), but decreased histone H3 Lys 9 dimethylation (H3K9me2).	Lysine	241-244	SU(VAR)3-9 homolog 5	Arabidopsis thaliana	105-110
32643178-7	2020	Moreover, it was demonstrated that the expression of seed dormancy-related genes was increased in hda19, suvh5 and hda19 suvh5 double mutant plants, which was associated with increased histone H3 acetylation (H3ac), but decreased histone H3 Lys 9 dimethylation (H3K9me2).	Lysine	241-244	histone deacetylase 1	Arabidopsis thaliana	115-120
32131585-5	2020	More strikingly, polymer nanospheres assembled from the polymer DNA wires and cationic poly-l-lysine further improved cellular uptake and continuously stimulate the lysosomal Toll-like receptor 9 of immune cells, thereby remarkably enhancing the activation of immune cells.	Lysine	87-100	toll like receptor 9	Homo sapiens	175-195
32643178-7	2020	Moreover, it was demonstrated that the expression of seed dormancy-related genes was increased in hda19, suvh5 and hda19 suvh5 double mutant plants, which was associated with increased histone H3 acetylation (H3ac), but decreased histone H3 Lys 9 dimethylation (H3K9me2).	Lysine	241-244	SU(VAR)3-9 homolog 5	Arabidopsis thaliana	121-126
33097091-2	2020	The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a reader of lysine 9 di- and tri-methylation on histone H3 (H3K9me2/me3) and, more recently, lysine 126 di- and tri-methylation on DNA ligase 1 (LIG1K126me2/me3).	Lysine	76-82	DNA ligase 1	Homo sapiens	195-207
32207962-2	2020	On the other hand, acetylation of lysine 16 (K16) residue greatly diminishes the fibrillization property of Abeta42 peptide and also affects its toxicity.	Lysine	34-40	keratin 16	Homo sapiens	45-48
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Lysine	21-27	potassium voltage-gated channel subfamily E regulatory subunit 2	Homo sapiens	72-77
31679457-6	2019	Here, we describe an arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2 in HEK293 cells.	Lysine	30-36	potassium voltage-gated channel subfamily E regulatory subunit 2	Homo sapiens	159-164
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	336-342	E1A binding protein p300	Homo sapiens	73-78
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	336-342	katanin regulatory subunit B1	Homo sapiens	63-66
32159963-3	2020	Proteome-wide comparisons of lysine methylation patterns reveal that DTPs display an increase in methylation on K116 of PRC member Jarid2, an event that helps stabilize and recruit PRC2 to chromatin.	Lysine	29-35	jumonji and AT-rich interaction domain containing 2	Homo sapiens	131-137
33097091-2	2020	The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a reader of lysine 9 di- and tri-methylation on histone H3 (H3K9me2/me3) and, more recently, lysine 126 di- and tri-methylation on DNA ligase 1 (LIG1K126me2/me3).	Lysine	157-163	DNA ligase 1	Homo sapiens	195-207
31700011-2	2019	We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model.	Lysine	27-33	K(lysine) acetyltransferase 5	Mus musculus	52-57
32564302-11	2020	The downregulation of BAPN-induced MMP2 expression by SIRT1 was mediated by deacetylation of histone H3 lysine 9 (H3K9) on the Mmp2 promoter in the A7r5 cells.	Lysine	104-110	matrix metallopeptidase 2	Rattus norvegicus	35-39
31700011-2	2019	We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model.	Lysine	27-33	K(lysine) acetyltransferase 5	Mus musculus	58-62
32238799-6	2020	Further, we found that ubiquitin ligase HUWE1 induced the K27-/K29-linked noncanonical ubiquitination of JMJD1A at lysine-918.	Lysine	115-121	keratin 27	Homo sapiens	58-61
32564302-11	2020	The downregulation of BAPN-induced MMP2 expression by SIRT1 was mediated by deacetylation of histone H3 lysine 9 (H3K9) on the Mmp2 promoter in the A7r5 cells.	Lysine	104-110	matrix metallopeptidase 2	Rattus norvegicus	127-131
31056736-4	2019	The present study examines the effect of charged amino acids Arg, Asp, and Lys on the stability of RNase A and alpha-LA.	Lysine	75-78	ribonuclease A family member 1, pancreatic	Homo sapiens	99-106
31056736-8	2019	The extent of stability provided by Asp and Glu is almost same and higher than Lys in RNase A.	Lysine	79-82	ribonuclease A family member 1, pancreatic	Homo sapiens	86-93
33028948-8	2020	Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8.	Lysine	67-73	lysine methyltransferase 5A	Homo sapiens	124-128
31404772-8	2019	L-Lysine treatment significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts.	Lysine	0-8	chemokine (C-X-C motif) ligand 15	Mus musculus	160-173
31909872-5	2020	NSD1 is a histone methyltransferase that catalyzes the methylation of lysine residue 36 on histone H3.	Lysine	70-76	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
32666581-1	2020	Diagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable diagnostic tool.	Lysine	200-206	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	151-156
32142654-2	2020	Here, we provide insight into how these responses are connected by the finding that ubiquitylation of RNAPII itself, at a single lysine (RPB1 K1268), is the focal point for DNA-damage-response coordination.	Lysine	129-135	RNA polymerase II subunit A	Homo sapiens	137-141
32143292-0	2020	Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes.	Lysine	0-6	vav guanine nucleotide exchange factor 1	Homo sapiens	66-70
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	F-box and leucine rich repeat protein 14	Homo sapiens	156-162
31488577-3	2019	Here, we identify the lysine residues at which EZH1/EZH2 are automethylated with EZH2-K510 and EZH2-K514 being the major such sites in vivo.	Lysine	22-28	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	47-51
31391253-2	2019	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) encodes the only lysyl hydroxylase (LH) isoform that specifically hydroxylates lysine residues in collagen telopeptides, a post-translational modification required for the formation of stabilized cross-links.	Lysine	12-18	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	52-57
32143292-4	2020	Here, we show that Vav1 becomes acetylated on lysine residues in a stimulation- and SH2 domain-dependent manner.	Lysine	46-52	vav guanine nucleotide exchange factor 1	Homo sapiens	19-23
32879443-5	2020	We demonstrated that knockdown of JMJD8 increased the interaction of SETDB1 and phosphoinositide-dependent kinase 1 (PDK1) with AKT1 and resulted in enhanced trimethylation of AKT1 at lysine 142 (K142), which is crucial for cell membrane recruitment, phosphorylation, and activation of AKT.	Lysine	184-190	jumonji domain containing 8	Homo sapiens	34-39
32143292-5	2020	Using a collection of both acetylation- and deacetylation-mimicking mutants, we show that the acetylation of four lysine residues (Lys222, Lys252, Lys587, and Lys716) leads to the downmodulation of the adaptor function of Vav1 that triggers the stimulation of the nuclear factor of activated T cells (NFAT).	Lysine	114-120	vav guanine nucleotide exchange factor 1	Homo sapiens	222-226
32143292-8	2020	Collectively, these results indicate that Nepsilon-lysine acetylation can play variegated roles in the regulation of Vav1 signaling.	Lysine	51-57	vav guanine nucleotide exchange factor 1	Homo sapiens	117-121
32879445-0	2020	Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.	Lysine	10-16	lysine methyltransferase 2B	Homo sapiens	55-60
32791177-5	2020	The persistent suppression of pancreatic angiotensin II receptor type 2 (AT2R) expression before and after birth could be observed in the PDE females, which is accompanied with decreased histone 3 lysine 14 acetylation (H3K14ac) and H3K27ac levels in AT2R promoter.	Lysine	197-203	angiotensin II receptor, type 2	Rattus norvegicus	41-71
31794431-3	2020	Lysine acetyltransferase 8 (KAT8) is critical for acetylation of histone H4 at lysine 16 (H4K16), an evolutionarily conserved epigenetic mark.	Lysine	79-85	lysine acetyltransferase 8	Homo sapiens	0-26
31794431-3	2020	Lysine acetyltransferase 8 (KAT8) is critical for acetylation of histone H4 at lysine 16 (H4K16), an evolutionarily conserved epigenetic mark.	Lysine	79-85	lysine acetyltransferase 8	Homo sapiens	28-32
31400111-4	2019	SET8 methylates UHRF1 at lysine 385 and this modification leads to ubiquitination and degradation of UHRF1.	Lysine	25-31	lysine methyltransferase 5A	Homo sapiens	0-4
32791177-5	2020	The persistent suppression of pancreatic angiotensin II receptor type 2 (AT2R) expression before and after birth could be observed in the PDE females, which is accompanied with decreased histone 3 lysine 14 acetylation (H3K14ac) and H3K27ac levels in AT2R promoter.	Lysine	197-203	angiotensin II receptor, type 2	Rattus norvegicus	73-77
32856656-2	2020	Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-terminal site-specific modification with lysine labeling.	Lysine	149-155	ribonuclease A family member 1, pancreatic	Homo sapiens	63-70
31433161-8	2019	Lysine fatty acylated RalB exhibited enhanced plasma membrane localization and recruited its known effectors Sec5 and Exo84, members of the exocyst complex, to the plasma membrane.	Lysine	0-6	exocyst complex component 2	Homo sapiens	109-113
32114388-11	2020	Mechanically, ZHX2 suppressed liver CSCs via inhibiting KDM2A-mediated demethylation of histone H3 lysine 36 (H3K36) at the promoter regions of stemness-associated transcription factors, such as NANOG, SOX4 and OCT4.	Lysine	99-105	zinc fingers and homeoboxes 2	Homo sapiens	14-18
32694775-5	2020	We demonstrate that acetylated SDHA at Lys 335 contributes to tumour growth in vitro and in vivo, and we confirm increased tumorigenesis in clinical samples.	Lysine	39-42	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	31-35
32101747-6	2020	We show that an Hdac7-Pkm2 complex acts as an immunometabolism signaling hub, whereby Pkm2 deacetylation at lysine 433 licenses its proinflammatory functions.	Lysine	108-114	histone deacetylase 7	Mus musculus	16-21
32101747-6	2020	We show that an Hdac7-Pkm2 complex acts as an immunometabolism signaling hub, whereby Pkm2 deacetylation at lysine 433 licenses its proinflammatory functions.	Lysine	108-114	pyruvate kinase, muscle	Mus musculus	22-26
32101747-6	2020	We show that an Hdac7-Pkm2 complex acts as an immunometabolism signaling hub, whereby Pkm2 deacetylation at lysine 433 licenses its proinflammatory functions.	Lysine	108-114	pyruvate kinase, muscle	Mus musculus	86-90
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	234-239
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	320-325
31209362-4	2020	Specifically, SIRT1 interacts with CHK2 and deacetylates it at lysine 520 residue, which suppresses CHK2 phosphorylation, dimerization, and thus activation.	Lysine	63-69	checkpoint kinase 2	Mus musculus	35-39
31209362-4	2020	Specifically, SIRT1 interacts with CHK2 and deacetylates it at lysine 520 residue, which suppresses CHK2 phosphorylation, dimerization, and thus activation.	Lysine	63-69	checkpoint kinase 2	Mus musculus	100-104
32015554-5	2020	Among the candidates, we characterized lysine 112 of the actin regulator cofilin as a novel neddylation event.	Lysine	39-45	cofilin 1	Homo sapiens	73-80
32206572-9	2020	Besides pathogenic variants of BAP1, rare missense variants were found in genes encoding lysine-specific histone methyltransferase SETD2 and SETDB1 and genes encoding subunits of the mSWI/SNF chromatin remodeling complex.	Lysine	89-95	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	131-136
31433647-0	2019	Kinetics of Poly-l-lysine Adsorption on Mica and Stability of Formed Monolayers: Theoretical and Experimental Studies.	Lysine	12-25	MHC class I polypeptide-related sequence A	Homo sapiens	40-44
31346037-5	2019	Using co-immunoprecipitation, MS, and methylation assays, we demonstrate that Mettl21c trimethylates heat shock protein 8 (Hspa8) at Lys-561 to enhance its stability.	Lysine	133-136	heat shock protein 8	Mus musculus	101-121
31346037-5	2019	Using co-immunoprecipitation, MS, and methylation assays, we demonstrate that Mettl21c trimethylates heat shock protein 8 (Hspa8) at Lys-561 to enhance its stability.	Lysine	133-136	heat shock protein 8	Mus musculus	123-128
31257132-7	2019	We found that BMI1 repressed multiple developmental programs in BMSCs by safeguarding the repressive epigenetic marks histone H2A ubiquitylation and H3 lysine 27 trimethylation.	Lysine	152-158	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	14-18
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	prostaglandin D2 receptor	Homo sapiens	23-26
31492160-11	2019	Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2.	Lysine	159-165	growth arrest and DNA damage inducible alpha	Homo sapiens	54-61
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	lysine methyltransferase 2B	Homo sapiens	83-87
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	lysine methyltransferase 2C	Homo sapiens	89-93
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	lysine methyltransferase 2B	Homo sapiens	95-99
31375747-5	2019	We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start sites (TSS) and super-enhancers (SEs) prominently in stem-like BrCa cells.	Lysine	136-142	histone deacetylase 3	Homo sapiens	24-29
31331996-5	2019	The effect of ATMS1 on chromatin silencing is related to decreased levels of DNA methylation (CG, CHG, and CHH) and histone-3 lysine-9 dimethylation.	Lysine	126-132	Cobalamin-independent synthase family protein	Arabidopsis thaliana	14-19
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	50-56	high mobility group box 1	Mus musculus	244-269
31399344-4	2019	Genetic depletion of SIRT6 or its chromatin deficiency upon glucose deprivation causes intragenic enrichment of acetylated histone H3 at lysines 9 (H3K9ac) and 56 (H3K56ac), activation of cyclin-dependent kinase 9 (CDK9)-that phosphorylates NELF and the carboxyl terminal domain of Pol II-and enrichment of the positive transcription elongation factors MYC, BRD4, PAF1, and the super elongation factors AFF4 and ELL2.	Lysine	137-144	sirtuin 6	Homo sapiens	21-26
31393052-6	2019	Moreover, ChIP assays found that sCD40L stimulation promotes histone H3 tri-methylation at lysine 4 (H3K4me3), H3K36me3, and H3K27 acetylation (H3K27ac) modifications on CD40 promoter region in pulmonary adventitial fibroblasts, while SFPQ overexpression decreases H3K36me3 modification and increases H3K36ac on CD40 promoter region by interacting with histone deacetylase-1 (HDAC1) to inhibit CD40 transcription.	Lysine	91-97	CD40 molecule	Homo sapiens	34-38
31388018-4	2019	Under the conditions optimized for lysine deprotonation, SETD3 has weak lysine methylation activity on an actin peptide in which the target His73 is substituted by a lysine.	Lysine	35-41	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	57-62
31388018-4	2019	Under the conditions optimized for lysine deprotonation, SETD3 has weak lysine methylation activity on an actin peptide in which the target His73 is substituted by a lysine.	Lysine	72-78	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	57-62
31531200-1	2019	The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational N-epsilon-acetylated lysine modifications, regulating transcription as "reader" proteins.	Lysine	110-116	delta/notch like EGF repeat containing	Homo sapiens	36-39
31368599-3	2019	MITOL promotes K63-linked chain ubiquitination of IRE1alpha at lysine 481 (K481), thereby preventing hyper-oligomerization of IRE1alpha and regulated IRE1alpha-dependent decay (RIDD).	Lysine	63-69	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	126-135
31368599-3	2019	MITOL promotes K63-linked chain ubiquitination of IRE1alpha at lysine 481 (K481), thereby preventing hyper-oligomerization of IRE1alpha and regulated IRE1alpha-dependent decay (RIDD).	Lysine	63-69	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	126-135
31194865-5	2019	Protein lysine modification (PLM), a hot spot of PTMs, was rarely studied except for a few reports on lysine methylation and acetylation.	Lysine	8-14	parathymosin	Homo sapiens	49-53
31417652-3	2019	SMYD3 can promote oncogenic progression by methylating lysines to integrate cytoplasmic kinase signaling cascades or by methylating histone lysines to regulate specific gene transcription.	Lysine	55-62	SET and MYND domain containing 3	Homo sapiens	0-5
31417652-3	2019	SMYD3 can promote oncogenic progression by methylating lysines to integrate cytoplasmic kinase signaling cascades or by methylating histone lysines to regulate specific gene transcription.	Lysine	140-147	SET and MYND domain containing 3	Homo sapiens	0-5
31266503-2	2019	Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues.	Lysine	183-189	delta/notch like EGF repeat containing	Homo sapiens	32-35
31062382-5	2019	Chromatin immunoprecipitation (ChIP) assay was used to verify the enrichment of EZH2 and histone H3 lysine 27 trimethylation (H3K27me3) in the promoter region of GSK-3beta in CRC cells.	Lysine	100-106	glycogen synthase kinase 3 beta	Homo sapiens	162-171
31267707-4	2019	Among the KATs that mediate lysine acetylation, males absent on the first (MOF/KAT8) is particularly notable for its ability to acetylate histone 4 lysine 16 (H4K16ac), a modification that decompacts chromatin structure.	Lysine	28-34	lysine acetyltransferase 8	Homo sapiens	79-83
31267707-4	2019	Among the KATs that mediate lysine acetylation, males absent on the first (MOF/KAT8) is particularly notable for its ability to acetylate histone 4 lysine 16 (H4K16ac), a modification that decompacts chromatin structure.	Lysine	148-154	lysine acetyltransferase 8	Homo sapiens	79-83
31067149-5	2019	Lysine residues within the transmembrane domain of Snc1 are necessary for presentation of a Snx4-Atg20-dependent sorting signal located within its juxtamembrane region.	Lysine	0-6	Atg20p	Saccharomyces cerevisiae S288C	97-102
31125786-4	2019	Here we report that Csk is covalently modified by SUMO1 at lysine 53 (K53) both in vitro and in vivo.	Lysine	59-65	C-terminal Src kinase	Homo sapiens	20-23
31125786-4	2019	Here we report that Csk is covalently modified by SUMO1 at lysine 53 (K53) both in vitro and in vivo.	Lysine	59-65	small ubiquitin like modifier 1	Homo sapiens	50-55
31125786-9	2019	Our results suggest that SUMOylation of Csk mainly at lysine 53 negatively modulates its tumor suppressor function by reducing its binding with Cbp and consequently, inducing c-Src activation.	Lysine	54-60	C-terminal Src kinase	Homo sapiens	40-43
30859592-7	2019	JMJ30 then removes a repressive histone mark, H3 lysine 27 trimethylation (H3K27me3), from the SNF1-related protein kinase 2.8 (SnRK2.8) promoter, and hence activates SnRK2.8 expression.	Lysine	49-55	2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein	Arabidopsis thaliana	0-5
30859592-7	2019	JMJ30 then removes a repressive histone mark, H3 lysine 27 trimethylation (H3K27me3), from the SNF1-related protein kinase 2.8 (SnRK2.8) promoter, and hence activates SnRK2.8 expression.	Lysine	49-55	Protein kinase superfamily protein	Arabidopsis thaliana	95-126
30859592-7	2019	JMJ30 then removes a repressive histone mark, H3 lysine 27 trimethylation (H3K27me3), from the SNF1-related protein kinase 2.8 (SnRK2.8) promoter, and hence activates SnRK2.8 expression.	Lysine	49-55	Protein kinase superfamily protein	Arabidopsis thaliana	128-135
31068455-6	2019	KNU also physically interacts with FERTILIZATION-INDEPENDENT ENDOSPERM, a key polycomb repressive complex2 component, and mediates the subsequent deposition of the repressive histone H3 lysine 27 trimethylation for stable silencing of WUS This multi-step silencing of WUS leads to the termination of floral stem cells, ensuring proper carpel development.	Lysine	186-192	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	0-3
31293590-1	2019	Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates.	Lysine	188-194	NEDD8 ubiquitin like modifier	Danio rerio	76-147
31293590-1	2019	Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates.	Lysine	188-194	NEDD8 ubiquitin like modifier	Danio rerio	149-154
31061100-3	2019	Lysine demethylase 5A (KDM5A) is a histone demethylase that removes trimethyl (me3) marks from lysine 4 of histone 3 (H3K4) and serves as a general transcriptional corepressor.	Lysine	95-101	lysine (K)-specific demethylase 5A	Mus musculus	23-28
30959089-6	2019	Moreover, the nicotinic acetylcholine receptors (nAChRs) expression was increased in utero, while histone 3 lysine 9 acetylation (H3K9ac) and H3K27ac levels in the P450arom promoter region were decreased persistently in PNE group before and after birth.	Lysine	108-114	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	164-172
31152160-4	2019	Depletion of H3.3 from mESCs reduces acetylation on histone H3 at lysine 27 (H3K27ac) at enhancers.	Lysine	66-72	histocompatibility 33	Mus musculus	13-17
30858544-5	2019	We identified four lysine residues in hnRNP A1 that were deacetylated by SIRT1 and SIRT6, resulting in significant inhibition of glycolysis in HCC cells.	Lysine	19-25	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	38-46
30858544-5	2019	We identified four lysine residues in hnRNP A1 that were deacetylated by SIRT1 and SIRT6, resulting in significant inhibition of glycolysis in HCC cells.	Lysine	19-25	sirtuin 6	Homo sapiens	83-88
30877109-6	2019	Increased association of polyubiquitinated DDX17 with p300-YAP resulted in histone 3 lysine 56 (H3K56) acetylation proximal to stemness-related genes and their subsequent transcriptional activation.	Lysine	85-91	E1A binding protein p300	Homo sapiens	54-58
30877109-6	2019	Increased association of polyubiquitinated DDX17 with p300-YAP resulted in histone 3 lysine 56 (H3K56) acetylation proximal to stemness-related genes and their subsequent transcriptional activation.	Lysine	85-91	Yes1 associated transcriptional regulator	Homo sapiens	59-62
31303989-5	2019	Mutant studies replacing Arg144 in galectin-3 with lysine and serine support the hypothesis that the binding of the derivatives involves interactions with Arg144.	Lysine	51-57	galectin 3	Homo sapiens	35-45
30827841-1	2019	Human ASH1L is the catalytic subunit of the conserved histone methyltransferase (HMTase) complex AMC that dimethylates lysine 36 in histone H3 (H3K36me2) to promote gene transcription in mammals and flies.	Lysine	119-125	ASH1 like histone lysine methyltransferase	Homo sapiens	6-11
30827843-1	2019	The evolutionarily conserved Trithorax group protein Ash1 is a SET domain histone methyltransferase that mono- and dimethylates lysine 36 of histone H3 (H3K36).	Lysine	128-134	ASH1 like histone lysine methyltransferase	Homo sapiens	53-57
30885946-7	2019	Furthermore, CHIP promoted ubiquitination of Tat by both WT as well as Lys-48-ubiquitin, which has only a single lysine residue at position 48.	Lysine	113-119	tyrosine aminotransferase	Homo sapiens	45-48
30900087-1	2019	Lysyl oxidase-like 4 (LOXL4), a member of the LOX family proteins, catalyzes oxidative deamination of lysine residues in collagen and elastin, which are responsible for maintaining extracellular matrix homeostasis.	Lysine	102-108	lysyl oxidase like 4	Homo sapiens	0-20
30900087-1	2019	Lysyl oxidase-like 4 (LOXL4), a member of the LOX family proteins, catalyzes oxidative deamination of lysine residues in collagen and elastin, which are responsible for maintaining extracellular matrix homeostasis.	Lysine	102-108	lysyl oxidase like 4	Homo sapiens	22-27
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Lysine	181-187	Janus kinase 2	Homo sapiens	27-31
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Lysine	181-187	mutS homolog 2	Homo sapiens	84-88
30053768-7	2019	The transversion mutation was located in the preceding exon of lysine-specific demethylase1 and Jumonji (Jmj)-C domain and the later one (deletion) in the cupin-like motif of KDM3A protein.	Lysine	63-69	jumonji and AT-rich interaction domain containing 2	Homo sapiens	105-108
30471104-6	2019	We prove that GlyRS has a bipartite nuclear leading sequences, and GlyRS is phosphorylated at Thr544 and Ser704 in the cytoplasm under the stimulation of amino acids (Met, Leu, and Lys).	Lysine	181-184	glycyl-tRNA synthetase 1	Bos taurus	14-19
30471104-6	2019	We prove that GlyRS has a bipartite nuclear leading sequences, and GlyRS is phosphorylated at Thr544 and Ser704 in the cytoplasm under the stimulation of amino acids (Met, Leu, and Lys).	Lysine	181-184	glycyl-tRNA synthetase 1	Bos taurus	67-72
31011153-7	2019	ERF109 upregulates ANTHRANILATE SYNTHASE alpha1 (ASA1)-a tryptophan biosynthesis gene in the auxin production pathway8-10-dependent on the pre-deposition of SET DOMAIN GROUP8 (SDG8)-mediated histone H3 lysine 36 trimethylation (H3K36me3)11 on the ASA1 locus.	Lysine	202-208	anthranilate synthase alpha subunit 1	Arabidopsis thaliana	49-53
31011153-7	2019	ERF109 upregulates ANTHRANILATE SYNTHASE alpha1 (ASA1)-a tryptophan biosynthesis gene in the auxin production pathway8-10-dependent on the pre-deposition of SET DOMAIN GROUP8 (SDG8)-mediated histone H3 lysine 36 trimethylation (H3K36me3)11 on the ASA1 locus.	Lysine	202-208	anthranilate synthase alpha subunit 1	Arabidopsis thaliana	247-251
31100039-6	2019	This mutation leads to an asparagine to lysine substitution ( p.Asn84Lys ) located in the extracellular domain of IL2RG, which is predicted to be pathogenic.	Lysine	40-46	interleukin 2 receptor subunit gamma	Homo sapiens	114-119
30837322-2	2019	Binding to the targets via the lysine-binding sites allows for Plg activation by plasminogen activators (PAs) present on the same target.	Lysine	31-37	plasminogen	Homo sapiens	63-66
31114249-1	2019	Purpose: Human males absent on the first (hMOF) is a histone acetyltransferase (HAT) and is responsible for acetylating histone H4 at lysine 16 (H4K16).	Lysine	134-140	lysine acetyltransferase 8	Homo sapiens	42-46
30990809-6	2019	RESULTS: We identified KMT2D, SETD1A and SETD2, included in the lysine methyltransferase activity function, as linked with poor prognosis in invasive breast cancer.	Lysine	64-70	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	41-46
30988309-5	2019	Using a combination of NMR spectroscopy, crosslinking mass-spectrometry, mutagenesis and data-driven modelling, here we show that RNF168 binds the acidic patch on the nucleosome surface, directing the E2 to the target lysine.	Lysine	218-224	ring finger protein 168	Homo sapiens	130-136
30755420-5	2019	We show here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling.	Lysine	35-41	Janus kinase 2	Homo sapiens	165-169
30692271-0	2019	E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair.	Lysine	137-143	ring finger protein 20	Mus musculus	21-26
30692271-2	2019	RNF20/RNF40-mediated monoubiquitination of histone H2B on lysine 120 (H2Bub) has been suggested as a potential mediator of DSB repair, although the nature and function of this posttranslational modification remain enigmatic.	Lysine	58-64	ring finger protein 20	Mus musculus	0-5
30631154-2	2019	Here, we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.	Lysine	62-69	keratin 27	Homo sapiens	21-24
30833342-3	2019	It was proposed that the Trithorax system acts via methylation of histone H3 at lysine 4 and lysine 36 (H3K36), thereby inhibiting histone methyltransferase activity of the Polycomb complexes.	Lysine	80-86	Polycomb	Drosophila melanogaster	173-181
32727878-11	2020	ISG15 is an IFN-inducible ubiquitin-like protein that is covalently conjugated to the viral protein via specific Lys residues and suppresses viral functions and viral propagation.	Lysine	113-116	ISG15 ubiquitin like modifier	Homo sapiens	0-5
30833342-3	2019	It was proposed that the Trithorax system acts via methylation of histone H3 at lysine 4 and lysine 36 (H3K36), thereby inhibiting histone methyltransferase activity of the Polycomb complexes.	Lysine	93-99	Polycomb	Drosophila melanogaster	173-181
30842237-6	2019	Mechanistically, KAT8 directly interacts with IRF3 and mediates IRF3 acetylation at lysine 359 via its MYST domain.	Lysine	84-90	interferon regulatory factor 3	Mus musculus	64-68
30842237-8	2019	Our study reveals a critical role for KAT8 and IRF3 lysine acetylation in the suppression of antiviral innate immunity.	Lysine	52-58	interferon regulatory factor 3	Mus musculus	47-51
32817139-3	2020	KDM6A physically associates with histone H3 lysine 4 monomethyltransferases MLL3 (KMT2C) and MLL4 (KMT2D).	Lysine	44-50	lysine methyltransferase 2C	Homo sapiens	76-80
32817139-3	2020	KDM6A physically associates with histone H3 lysine 4 monomethyltransferases MLL3 (KMT2C) and MLL4 (KMT2D).	Lysine	44-50	lysine methyltransferase 2C	Homo sapiens	82-87
32900932-8	2020	Five key lysine residues in Msh3 are direct targets of HDAC3 deacetylation.	Lysine	9-15	mutS homolog 3	Homo sapiens	28-32
30909412-6	2019	Immunoblots showed that MK-STYX decreases HDAC6 serine phosphorylation, protein tyrosine phosphorylation, and lysine acetylation.	Lysine	110-116	serine/threonine/tyrosine interacting like 1	Homo sapiens	24-31
32900932-8	2020	Five key lysine residues in Msh3 are direct targets of HDAC3 deacetylation.	Lysine	9-15	histone deacetylase 3	Homo sapiens	55-60
32900932-9	2020	In cells expressing Msh3 in which these lysine residues are mutated to arginine, the inhibitory effect of RGFP966 on expansions is largely bypassed, consistent with the direct deacetylation hypothesis.	Lysine	40-46	mutS homolog 3	Homo sapiens	20-24
30840873-2	2019	(2019) report the crystal structure of a lysine-methylated non-histone peptide from DNA ligase 1 (LIG1K126me3) bound to the UHRF1 tandem Tudor domain (TTD).	Lysine	41-47	DNA ligase 1	Homo sapiens	84-96
32789493-5	2020	SIRT6 deacetylated DDB2 at two lysine residues, K35 and K77, upon UV stress and then promoted DDB2 ubiquitination and segregation from chromatin, thereby facilitating downstream signaling.	Lysine	31-37	sirtuin 6	Homo sapiens	0-5
30526058-4	2019	In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180.	Lysine	96-102	K(lysine) acetyltransferase 2B	Mus musculus	28-32
30526058-4	2019	In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180.	Lysine	96-102	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	48-74
30526058-4	2019	In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180.	Lysine	96-102	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	76-80
32789493-5	2020	SIRT6 deacetylated DDB2 at two lysine residues, K35 and K77, upon UV stress and then promoted DDB2 ubiquitination and segregation from chromatin, thereby facilitating downstream signaling.	Lysine	31-37	damage specific DNA binding protein 2	Homo sapiens	19-23
33042830-1	2020	KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play a central role in transcriptional repression.	Lysine	96-99	lysine demethylase 5C	Homo sapiens	0-5
30526058-6	2019	Site-directed mutagenesis and functional studies indicate that PCAF regulates IDH2, acting at dual level during myoblast differentiation: at a transcriptional level together with MyoD, and at a post-translational level by direct modification of lysine acetylation in mitochondria.	Lysine	245-251	K(lysine) acetyltransferase 2B	Mus musculus	63-67
30526058-6	2019	Site-directed mutagenesis and functional studies indicate that PCAF regulates IDH2, acting at dual level during myoblast differentiation: at a transcriptional level together with MyoD, and at a post-translational level by direct modification of lysine acetylation in mitochondria.	Lysine	245-251	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	78-82
32947834-5	2020	Furthermore, an analysis of the amino acid composition indicated that the silk fibroin suffered less damage because papain specifically cleaved the binding sites between L-arginine or L-lysine residue and another amino acid residue in sericin, leading to a significantly higher molecular weight and improved tensile strength compared to traditional sodium carbonate degumming.	Lysine	184-192	fibroin light chain	Bombyx mori	79-86
30867593-0	2019	Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.	Lysine	29-35	methyltransferase like 3	Mus musculus	46-49
32943985-10	2020	XIST promoted methylation of histone H3 methylation at lysine 4 by enhancing the stability of lysine (K)-specific methyltransferase 2C (KMT2C) mRNA.	Lysine	55-61	lysine (K)-specific methyltransferase 2C	Mus musculus	136-141
30541086-9	2019	Furthermore, PhNSun6 lacks the eukaryotic NSun6-specific Lys-rich loop, resulting in the non-recognition of D-stem region by PhNSun6.	Lysine	57-60	NOP2/Sun RNA methyltransferase 6	Homo sapiens	15-20
32943985-10	2020	XIST promoted methylation of histone H3 methylation at lysine 4 by enhancing the stability of lysine (K)-specific methyltransferase 2C (KMT2C) mRNA.	Lysine	94-100	lysine (K)-specific methyltransferase 2C	Mus musculus	136-141
32526202-3	2020	Here we reveal that HDAC1-mediated global histone deacetylation and the gain of specific histone H3 lysine 27 acetylation (H3K27ac)-marked enhancers are essential for the TGF-beta-induced EMT process.	Lysine	100-106	transforming growth factor alpha	Homo sapiens	171-179
30818762-1	2019	The non-redundant histone methyltransferase SETD2 (SET domain containing 2; KMT3A) is responsible for tri-methylation of lysine 36 on histone H3 (H3K36me3).	Lysine	121-127	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	44-49
30818762-1	2019	The non-redundant histone methyltransferase SETD2 (SET domain containing 2; KMT3A) is responsible for tri-methylation of lysine 36 on histone H3 (H3K36me3).	Lysine	121-127	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	76-81
31243359-7	2020	Functionally, we determined that the absence of the TIR domain in BANK1-D2 is important for its lysine (K)63-linked polyubiquitination and its ability to produce interleukin (IL)-8.	Lysine	96-102	B cell scaffold protein with ankyrin repeats 1	Mus musculus	66-71
30538136-7	2019	Replacement of R401W with leucine and then lysine progressively restores HMGB1 binding, correlating with increased RAG cutting and recombination in vivo.	Lysine	43-49	high mobility group box 1	Homo sapiens	73-78
32345914-0	2020	Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia via attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription.	Lysine	94-100	glutamate receptor, ionotropic, kainate 1	Mus musculus	135-141
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	44-85
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	87-93
32867667-0	2021	H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma.	Lysine	28-34	lysine methyltransferase 2C	Homo sapiens	62-67
30661771-1	2019	Hypusine is formed post-translationally from lysine and is found in a single cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolog eIF5A2.	Lysine	45-51	eukaryotic translation initiation factor 5A2	Homo sapiens	164-170
32842698-6	2020	With 11.3 wt% Lys@BNNP incorporated, the thermal conductivity of Lys@BNNP/PVA hydrogel composite was up to 0.91 W m-1K-1, increased by 78%, comparing to the neat PVA hydrogel.	Lysine	14-17	keratin 1	Homo sapiens	117-120
30736831-4	2019	Mutation of a cluster of lysines present in the intracellular N-terminus region of beta-ENaC (K4R/ K5R/ K9R/ K16R/ K23R) reduced interactions with Cav3.2 calcium channels.	Lysine	25-32	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	147-153
32842698-6	2020	With 11.3 wt% Lys@BNNP incorporated, the thermal conductivity of Lys@BNNP/PVA hydrogel composite was up to 0.91 W m-1K-1, increased by 78%, comparing to the neat PVA hydrogel.	Lysine	65-68	keratin 1	Homo sapiens	117-120
30638745-4	2019	Exogenous NeuroD1 initially occupies closed chromatin regions associated with bivalent trimethylation of histone H3 at lysine 4 (H3K4me3) and H3K27me3 marks in microglia to induce neuronal gene expression.	Lysine	119-125	neurogenic differentiation 1	Mus musculus	10-17
32639142-1	2020	Acetylation of alpha-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities.	Lysine	42-48	keratin 40	Homo sapiens	53-56
30476558-1	2019	GnRH receptor mutations, Glu2.53(90)Lys and Glu2.53(90)Asp, cause congenital hypogonadotropic hypogonadism.	Lysine	36-39	gonadotropin releasing hormone receptor	Homo sapiens	0-13
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Lysine	41-44	transient receptor potential cation channel subfamily C member 6	Homo sapiens	117-121
33014799-10	2020	Knockdown of LINC00673 significantly enhanced posttranscriptional expression of CDKN2C, and histone 3 lysine 27 trimethylation (H3K27me3) was enriched at the promoter region of CDKN2C.	Lysine	102-108	long intergenic non-protein coding RNA 673	Homo sapiens	13-22
30362103-4	2019	LOXL3 is a member of the lysyl oxidase family of genes which encode enzymes oxidizing the side chain of peptidyl lysine permitting the covalent crosslinking of collagen and elastin chains.	Lysine	113-119	lysyl oxidase like 3	Homo sapiens	0-5
30538128-6	2019	Using mammalian cells, molecular modeling, substrate-capture assays, and mutagenic analyses, we identified a single conserved surface Lys (Lys-127) residue as well as active-site interactions of the SNO group that mediate recognition of SNO-CoA by SCoR.	Lysine	134-137	strawberry notch homolog 1	Homo sapiens	199-202
32628956-10	2020	Protein footprinting of accessible lysine residues reveals an extended, bipartite candidate DNA/chromatin binding surface in the C-terminal region of PSC.	Lysine	35-41	Posterior sex combs	Drosophila melanogaster	150-153
30538128-6	2019	Using mammalian cells, molecular modeling, substrate-capture assays, and mutagenic analyses, we identified a single conserved surface Lys (Lys-127) residue as well as active-site interactions of the SNO group that mediate recognition of SNO-CoA by SCoR.	Lysine	134-137	strawberry notch homolog 1	Homo sapiens	237-240
30538128-6	2019	Using mammalian cells, molecular modeling, substrate-capture assays, and mutagenic analyses, we identified a single conserved surface Lys (Lys-127) residue as well as active-site interactions of the SNO group that mediate recognition of SNO-CoA by SCoR.	Lysine	139-142	strawberry notch homolog 1	Homo sapiens	199-202
30538128-6	2019	Using mammalian cells, molecular modeling, substrate-capture assays, and mutagenic analyses, we identified a single conserved surface Lys (Lys-127) residue as well as active-site interactions of the SNO group that mediate recognition of SNO-CoA by SCoR.	Lysine	139-142	strawberry notch homolog 1	Homo sapiens	237-240
33042742-5	2020	A missense single nucleotide variation rs61955126 T>C in the lysine methyltransferase SETD8 (accession: NM_020382, SETD8C302R ) is exposed.	Lysine	61-67	lysine methyltransferase 5A	Homo sapiens	86-91
30516430-4	2019	Here, we show that periplakin is SUMOylated at a conserved lysine in its linker domain (K1646) preferentially by small ubiquitin-like modifier 1 (SUMO1).	Lysine	59-65	small ubiquitin like modifier 1	Homo sapiens	113-144
30516430-4	2019	Here, we show that periplakin is SUMOylated at a conserved lysine in its linker domain (K1646) preferentially by small ubiquitin-like modifier 1 (SUMO1).	Lysine	59-65	small ubiquitin like modifier 1	Homo sapiens	146-151
32747680-3	2020	The enzymatic activity of MOF, PCAF and GCN5 acetyltransferases towards histone peptides bearing lysine analogs was evaluated using MALDI-TOF MS assays.	Lysine	97-103	lysine acetyltransferase 8	Homo sapiens	26-29
30519811-4	2019	The eIF5A protein contains an exclusive amino acid residue denominated hypusine, which is essential for its activity and synthesized by posttranslational modification of a specific lysine residue using spermidine as substrate.	Lysine	181-187	eukaryotic translation initiation factor 5A	Rattus norvegicus	4-9
32520610-0	2020	The pH dependence of the Slc4a11-mediated H+-conductance is influenced by intracellular lysine residues and modified by disease-linked mutations.	Lysine	88-94	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	25-32
30975281-11	2019	Conclusion C/EBPalpha can be modified by SUMO1 and the site of its modification is the 161st lysine in human AECII.	Lysine	93-99	small ubiquitin like modifier 1	Homo sapiens	41-46
30442713-5	2019	Our studies showed that L3MBTL3 preferentially binds to the methylated Lys-42 in SOX2, although mutation of Lys-117 also partially reduces the interaction between SOX2 and L3MBTL3.	Lysine	71-74	L3MBTL3 histone methyl-lysine binding protein	Mus musculus	24-31
31240519-0	2020	Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules.	Lysine	73-79	sirtuin 6	Homo sapiens	27-32
30446621-7	2019	In human CD147, binding of CAIV was mediated by the negatively charged Glu-73 and in rat CD147 by the positively charged Lys-73.	Lysine	121-124	carbonic anhydrase 4	Homo sapiens	27-31
31240519-3	2020	We identified novel SIRT6 modulators with a lysine-based structure: compound 1 enhances SIRT6 deacylase while inhibiting the deacetylase activity.	Lysine	44-50	sirtuin 6	Homo sapiens	20-25
31240519-3	2020	We identified novel SIRT6 modulators with a lysine-based structure: compound 1 enhances SIRT6 deacylase while inhibiting the deacetylase activity.	Lysine	44-50	sirtuin 6	Homo sapiens	88-93
31155583-11	2019	Because similar regulation of total homocysteine/citrulline/Lys was observed in the CSF of Cth-/- mice, which are free of CNS dysfunction, the reduced CSF volumes and the level changes of other amino acids could be relevant to Cbs-/--specific CNS defects.	Lysine	60-63	cystathionase (cystathionine gamma-lyase)	Mus musculus	91-94
31240519-4	2020	As expected based on the biological effects of SIRT6 deacetylase activity, compound 1 increased histone 3 lysine 9 acetylation and the activity of glycolytic enzymes.	Lysine	106-112	sirtuin 6	Homo sapiens	47-52
31240519-6	2020	In conclusion, new SIRT6 modulators with a lysine-like structure were identified, with differential effects on specific SIRT6 activities.	Lysine	43-49	sirtuin 6	Homo sapiens	19-24
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	SUMO specific peptidase 2	Homo sapiens	17-22
31240519-6	2020	In conclusion, new SIRT6 modulators with a lysine-like structure were identified, with differential effects on specific SIRT6 activities.	Lysine	43-49	sirtuin 6	Homo sapiens	120-125
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	290-304
32324922-2	2020	Among the numerous chromatin modifiers identified in Arabidopsis (Arabidopsis thaliana), MORF RELATED GENE 1 (MRG1) and MRG2 have redundant functions in reading histone H3 lysine 36 trimethylation (H3K36me3).	Lysine	172-178	MRG family protein	Arabidopsis thaliana	89-108
32324922-2	2020	Among the numerous chromatin modifiers identified in Arabidopsis (Arabidopsis thaliana), MORF RELATED GENE 1 (MRG1) and MRG2 have redundant functions in reading histone H3 lysine 36 trimethylation (H3K36me3).	Lysine	172-178	MRG family protein	Arabidopsis thaliana	110-114
30267992-3	2019	To this end, human plasma gels were synthesized with the addition of increasing concentrations of transglutaminase (TGase), which catalyses the formation of covalent bonds between Lys and Glu residues.	Lysine	180-183	transglutaminase 1	Homo sapiens	98-114
30267992-3	2019	To this end, human plasma gels were synthesized with the addition of increasing concentrations of transglutaminase (TGase), which catalyses the formation of covalent bonds between Lys and Glu residues.	Lysine	180-183	transglutaminase 1	Homo sapiens	116-121
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	Lysine	186-192	ribosomal protein S10	Homo sapiens	217-222
31379142-5	2019	In the delt1-2 allele, the antepenultimate residue, glutamic acid (E919), at the C-terminus of RBOHD was mutated to lysine (K).	Lysine	116-122	respiratory burst oxidase homologue D	Arabidopsis thaliana	95-100
32651355-8	2020	Mechanistically, LINC01446 could widely interact with histone lysine-specific demethylase LSD1 and recruit LSD1 to the Ras-related dexamethasone-induced 1 (RASD1) promoter, thereby suppressing RASD1 transcription.	Lysine	62-68	long intergenic non-protein coding RNA 1446	Homo sapiens	17-26
30566427-4	2018	We further show that PPARgamma is a direct substrate of Smurf1-mediated non-proteolytic lysine 63 (K63)-linked ubiquitin modification that suppresses its transcriptional activity, and treatment of Smurf1-deficient mice with a PPARgamma antagonist, GW9662, completely reversed the lipid accumulation in the liver.	Lysine	88-94	peroxisome proliferator activated receptor gamma	Mus musculus	21-30
32459350-2	2020	Here we discover an HRP2-DPF3a-BAF epigenetic pathway that coordinates methylated histone H3 lysine 36 (H3K36me) and ATP-dependent chromatin remodeling to regulate chromatin dynamics and gene transcription during myogenic differentiation.	Lysine	93-99	HDGF like 2	Mus musculus	20-24
30461258-9	2018	Mutation of R89 to lysine restored a portion of the inhibition of hNE (27 nM).	Lysine	19-25	elastase, neutrophil expressed	Homo sapiens	66-69
32459093-6	2020	DS@MA-LS was designed to prolong blood circulation and deshield PEG shell under MMP2 cleavage to expose lysine and target overexpressed ATB0,+ for enhanced tumor distribution and cancer cellular uptake.	Lysine	104-110	matrix metallopeptidase 2	Homo sapiens	80-84
30194699-0	2018	Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly-l-lysine/hyaluronic acid for ligament tissue engineering.	Lysine	72-85	phospholipase C like 1 (inactive)	Homo sapiens	38-42
32754263-13	2020	Mechanistically, ZFP91 promoted the Lys48-linked ubiquitination of the oncoprotein hnRNP A1 at lysine 8 and proteasomal degradation, thereby inhibiting hnRNP A1-dependent PKM splicing, subsequently resulting in higher PKM1 isoform formation and lower PKM2 isoform formation and suppressing HCC glucose metabolism reprogramming, cell proliferation and metastasis.	Lysine	95-101	zinc finger protein 91	Mus musculus	17-22
30424580-8	2018	In addition, we determined that following the loss of Kat2a activity, overall histone 3 lysine 9 (H3K9) acetylation, the main epigenetic target of Kat2a/Kat2b, was decreased.	Lysine	88-94	K(lysine) acetyltransferase 2B	Mus musculus	153-158
32754263-13	2020	Mechanistically, ZFP91 promoted the Lys48-linked ubiquitination of the oncoprotein hnRNP A1 at lysine 8 and proteasomal degradation, thereby inhibiting hnRNP A1-dependent PKM splicing, subsequently resulting in higher PKM1 isoform formation and lower PKM2 isoform formation and suppressing HCC glucose metabolism reprogramming, cell proliferation and metastasis.	Lysine	95-101	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	83-91
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Lysine	149-152	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
30417138-2	2018	Histone acetyltransferases (HATs) comprise a KAT sub-class that acetylate specific lysines in histones, hence playing an important role in the regulation of chromatin organization and function.	Lysine	83-90	thiosulfate sulfurtransferase (rhodanese)-like domain containing 1	Mus musculus	45-48
32541040-5	2020	Upon oxidative insult, SUMO2 is extensively conjugated to E2F1 mainly at lysine 266 residue, which specifically modulates E2F1 transcriptional activity to enhance cell cycle arrest for cell survival.	Lysine	73-79	E2F transcription factor 1 L homeolog	Xenopus laevis	58-62
29472715-5	2018	Kaiso is monoSUMOylated at lysine 42 in cell lines of kidney origin under normal physiological conditions.	Lysine	27-33	zinc finger and BTB domain containing 33	Mus musculus	0-5
32541040-5	2020	Upon oxidative insult, SUMO2 is extensively conjugated to E2F1 mainly at lysine 266 residue, which specifically modulates E2F1 transcriptional activity to enhance cell cycle arrest for cell survival.	Lysine	73-79	E2F transcription factor 1 L homeolog	Xenopus laevis	122-126
32376690-7	2020	Accordingly, GCN5- and HAT1-catalyzed acetylation of specific lysine residues on histones H3 and H4 was stimulated by polyamines.	Lysine	62-68	histone aminotransferase 1	Mus musculus	23-27
30205953-0	2018	Acetylation of lysine residues in the recombinant nucleoprotein and VP40 matrix protein of Zaire Ebolavirus by eukaryotic histone acetyltransferases.	Lysine	15-21	nucleoprotein	Zaire ebolavirus	50-63
32366460-4	2020	Histone acetyltransferase 1 (HAT1) is responsible for the cytosolic diacetylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled chromatin assembly.	Lysine	117-124	histone aminotransferase 1	Mus musculus	0-27
30286792-4	2018	One of the identified substrates, activating transcriptional factor 7-interacting protein 1 (ATF7IP), is tri-methylated at a histone H3 lysine 9 (H3K9)-like mimic by the G9a/GLP complex, although this complex mainly introduces di-methylation on H3K9 and DNA ligase 1 (LIG1) K126 in cells.	Lysine	136-142	DNA ligase 1	Homo sapiens	254-266
30286792-4	2018	One of the identified substrates, activating transcriptional factor 7-interacting protein 1 (ATF7IP), is tri-methylated at a histone H3 lysine 9 (H3K9)-like mimic by the G9a/GLP complex, although this complex mainly introduces di-methylation on H3K9 and DNA ligase 1 (LIG1) K126 in cells.	Lysine	136-142	DNA ligase 1	Homo sapiens	268-272
30286792-5	2018	The catalytic domain of G9a showed a higher affinity for di-methylated lysine on ATF7IP than LIG1, which may create different methylation levels of different substrates in cells.	Lysine	71-77	DNA ligase 1	Homo sapiens	93-97
32366460-4	2020	Histone acetyltransferase 1 (HAT1) is responsible for the cytosolic diacetylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled chromatin assembly.	Lysine	117-124	histone aminotransferase 1	Mus musculus	29-33
32401531-6	2020	We also identify lysine 128 near the C-terminus of UbcH5 as a critical residue for efficient ubiquitin transfer by UbcH5 in both the presence and absence of CHIP.	Lysine	17-23	ubiquitin conjugating enzyme E2 D1	Homo sapiens	115-120
32521276-1	2020	Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-, and trimethylation (H3K36me1/2/3).	Lysine	37-43	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-4
30140938-4	2018	On the other hand, the excessive SUV39h2 binds to more substrate histone H3, triggering an increase of tri-methylation of histone H3 on the ninth lysine.	Lysine	146-152	SUV39H2 histone lysine methyltransferase	Homo sapiens	33-40
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	E1A binding protein p300	Homo sapiens	232-236
30310315-8	2018	KMT2C gene mutations were mainly detected in HER2+ samples (7/10), which were correlated with the lysine degradation pathway.	Lysine	98-104	lysine methyltransferase 2C	Homo sapiens	0-5
32521276-4	2020	Here, we use engineered forms of Set2 that produce different lysine methylation states to identify unique and shared functions for H3K36 modifications.	Lysine	61-67	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	33-37
32181984-1	2020	EP300 and CBP are two highly homologous, multidomain, epigenetic coregulators that play central roles in transcription via acetylation of lysine residues on histones and other proteins.	Lysine	138-144	E1A binding protein p300	Homo sapiens	0-5
30209253-4	2018	Upon mitotic exit, chromatin relaxation is controlled by SET8-dependent methylation of histone H4 on lysine 20.	Lysine	101-107	lysine methyltransferase 5A	Homo sapiens	57-61
31811670-4	2020	A key feature that emerges as a result of eIF4E phosphorylation is a salt-bridge network between the phosphorylated S209 (pS209) and a specific pair of lysine residues (K159 and K162) within the cap-binding interface on eIF4E.	Lysine	152-158	eukaryotic translation initiation factor 4E	Homo sapiens	42-47
30209341-0	2018	The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons.	Lysine	48-54	cyclin-dependent kinase 5	Rattus norvegicus	19-44
31811670-4	2020	A key feature that emerges as a result of eIF4E phosphorylation is a salt-bridge network between the phosphorylated S209 (pS209) and a specific pair of lysine residues (K159 and K162) within the cap-binding interface on eIF4E.	Lysine	152-158	eukaryotic translation initiation factor 4E	Homo sapiens	220-225
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	interferon regulatory factor 3	Homo sapiens	36-40
30146412-7	2018	SIRT1 deacetylated TET2 at conserved lysine residues in its catalytic domain, enhancing TET2 activity.	Lysine	37-43	tet methylcytosine dioxygenase 2	Homo sapiens	19-23
30146412-7	2018	SIRT1 deacetylated TET2 at conserved lysine residues in its catalytic domain, enhancing TET2 activity.	Lysine	37-43	tet methylcytosine dioxygenase 2	Homo sapiens	88-92
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	keratin 27	Homo sapiens	85-88
29749709-6	2018	Transcriptional repression was probably achieved by Setdb2 through H3 methylation at lysine 9 in promoter regions of these antifungal genes.	Lysine	85-91	SET domain, bifurcated 2	Mus musculus	52-58
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	interferon regulatory factor 3	Homo sapiens	135-139
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	interferon regulatory factor 3	Homo sapiens	135-139
32528730-6	2020	In contrast, activation of SIRT1 increased autophagy in chondrocytes by the deacetylation of lysine residues on crucial autophagy proteins (Beclin1, ATG5, ATG7, LC3).	Lysine	93-99	autophagy related 7	Homo sapiens	155-159
30184226-0	2018	Lysine Stimulates Protein Synthesis by Promoting the Expression of ATB0,+ and Activating the mTOR Pathway in Bovine Mammary Epithelial Cells.	Lysine	0-6	solute carrier family 1 member 5	Bos taurus	67-71
32460017-5	2020	Upon DC activation, JNK signaling stimulated p300 association with PKM2 for the acetylation of lysine 433, a classic posttranslational modification critical for PKM2 destabilization and nuclear re-localization.	Lysine	95-101	E1A binding protein p300	Homo sapiens	45-49
30184226-0	2018	Lysine Stimulates Protein Synthesis by Promoting the Expression of ATB0,+ and Activating the mTOR Pathway in Bovine Mammary Epithelial Cells.	Lysine	0-6	mechanistic target of rapamycin kinase	Bos taurus	93-97
32313942-6	2020	HBXIP induced HMGA2 acetylation at the lysine 26 (K26), resulting in HMGA2 protein accumulation.	Lysine	39-45	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	0-5
29848782-6	2018	We also systematically investigated the formation of diagnostic ions or neutral losses for all PTMs, confirming 10 known and identifying 5 novel diagnostic ions for lysine modifications.	Lysine	165-171	parathymosin	Homo sapiens	95-99
32173363-1	2020	Transcriptional coactivators p300 and CBP catalyze the acetylation of lysine residues in histone proteins.	Lysine	70-76	E1A binding protein p300	Homo sapiens	29-33
29957571-7	2018	In response to mannitol treatment, histone H3 lysine 4 trimethylation (H3K4me3) and H3 acetylation (H3ac) levels within the promoter, TSS, and gene-body regions of AtMYB44 were significantly increased.	Lysine	46-52	myb domain protein r1	Arabidopsis thaliana	164-171
29185849-4	2020	Monoubiquitylation of KRAS at lysine 147 (mUbRAS) enhances Ras activation and promotes signaling through the RAF and Phosphoinositide 3-Kinase (PI3K) signaling pathways.	Lysine	30-36	zinc fingers and homeoboxes 2	Homo sapiens	109-112
30096423-5	2018	Caucasian EPHX2 Arg55 carriers (Lys/Arg or Arg/Arg) had a significantly higher risk of 5-year mortality (adjusted hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.01-2.55, P = 0.045).	Lysine	32-35	epoxide hydrolase 2	Homo sapiens	10-15
29954944-4	2018	We further reveal that mutant p53 forms physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFalpha-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation.	Lysine	208-214	lysine methyltransferase 2B	Homo sapiens	96-100
29954944-4	2018	We further reveal that mutant p53 forms physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFalpha-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation.	Lysine	208-214	lysine methyltransferase 2B	Homo sapiens	138-142
32112098-3	2020	MORC2 is acetylated by the acetyltransferase NAT10 at lysine 767 (K767Ac) and this process is counteracted by the deacetylase SIRT2 under unperturbed conditions.	Lysine	54-60	MORC family CW-type zinc finger 2	Homo sapiens	0-5
30028605-9	2018	The LC-MS/MS data indicated that Cy3 was predominately bound to another lysine, K31, on the protein surface on the opposite side of the calyx.	Lysine	72-78	keratin 31	Homo sapiens	80-83
32132173-10	2020	Our results indicate that a small-molecule inhibitor targeting the lysine-binding site of KIV-10 can combat the pathophysiological effects of Lp(a).	Lysine	67-73	lipoprotein(a)	Homo sapiens	142-147
31241013-5	2020	USP8 preferentially removed the lysine 11 (K11)-linked ubiquitin chains from SQSTM1.	Lysine	32-38	ubiquitin specific peptidase 8	Mus musculus	0-4
30061404-6	2018	In addition, enrichment of histone H3 lysine 4 trimethylation (a mark of gene activation) at the PGC-1alpha locus was markedly reduced in Smyd1-KO mice, and Smyd1-induced transcriptional activation of PGC-1alpha was confirmed by luciferase reporter assays.	Lysine	38-44	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	97-107
29752946-14	2018	The UCP-2 gene showed a significant increase in proline and lysine treatment.	Lysine	60-66	uncoupling protein 2	Homo sapiens	4-9
30069050-6	2018	IP6 makes ionic contacts with two rings of lysine residues at the centre of the Gag hexamer.	Lysine	43-49	Pr55(Gag)	Human immunodeficiency virus 1	80-83
31241013-5	2020	USP8 preferentially removed the lysine 11 (K11)-linked ubiquitin chains from SQSTM1.	Lysine	32-38	sequestosome 1	Mus musculus	77-83
32147842-6	2020	In addition, applying amino acids to meat surface significantly influenced (P < 0.05) pH and surface color change of beef crusts; particularly, lysine at 0.20% and 0.50% increased pH and a* (redness) but reduced b* (yellowness), while tryptophan and leucine at 0.50% increased L* (whiteness).	Lysine	144-150	phenylalanine hydroxylase	Homo sapiens	86-88
30012592-1	2018	The importance of BET protein BRD4 in gene transcription is well recognized through the study of chemical modulation of its characteristic tandem bromodomain (BrD) binding to lysine-acetylated histones and transcription factors.	Lysine	175-181	delta/notch like EGF repeat containing	Homo sapiens	18-21
32147842-6	2020	In addition, applying amino acids to meat surface significantly influenced (P < 0.05) pH and surface color change of beef crusts; particularly, lysine at 0.20% and 0.50% increased pH and a* (redness) but reduced b* (yellowness), while tryptophan and leucine at 0.50% increased L* (whiteness).	Lysine	144-150	phenylalanine hydroxylase	Homo sapiens	180-182
29760280-0	2018	Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration.	Lysine	55-61	prominin 1	Homo sapiens	46-51
32169821-4	2020	Here, we show a role for the non-redundant histone H3 lysine methyltransferase, Setd2, and its modification of lysine-36 trimethylation (H3K36me3), in the processing and joining of DNA ends during V(D)J recombination.	Lysine	54-60	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	80-85
29760280-5	2018	The lysine 848 residue at the intracellular carboxyl terminus is one of the sites for CD133 ubiquitination.	Lysine	4-10	prominin 1	Homo sapiens	86-91
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	SUMO1/sentrin specific peptidase 1	Mus musculus	262-267
32105459-0	2020	Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.	Lysine	13-19	eukaryotic translation initiation factor 4E	Homo sapiens	29-34
29603600-4	2018	Of interest in the transplant setting, modulation of the acetylation or deacetylation of key lysine residues in Foxp3 can promote the stability and function, leading to increased Treg production and increased Treg suppressive activity.	Lysine	93-99	forkhead box P3	Homo sapiens	112-117
32105459-5	2020	Taking advantage of a "make-on-demand" virtual library, we used covalent docking to identify arylsulfonyl fluorides that target a noncatalytic lysine (Lys162) in eIF4E.	Lysine	143-149	eukaryotic translation initiation factor 4E	Homo sapiens	162-167
32105459-7	2020	In addition to providing a new tool for acutely inactivating eIF4E in cells, our computational approach may offer a general strategy for developing selective lysine-targeted covalent ligands.	Lysine	158-164	eukaryotic translation initiation factor 4E	Homo sapiens	61-66
31544977-8	2020	Mechanistically, AGG-induced cytoplasmic SIRT1 deacetylated a Lys residue on the cytoplasmic domain of lysosome-associated membrane protein 1 (LAMP1), an autolysosomal protein, resulting in lipophagy and senescence.	Lysine	62-65	lysosomal associated membrane protein 1	Homo sapiens	103-141
30008699-1	2018	The broad-spectrum amino acid racemase (Alr) of Pseudomonas putida KT2440 preferentially interconverts the l- and d-stereoisomers of Lys and Arg.	Lysine	133-136	alanine racemase	Pseudomonas putida KT2440	40-43
30008699-11	2018	This is consistent with a predicted role for Alr in catabolism of l-Lys by virtue of its ability to convert l-Lys to d-Lys, which is further catabolized through the l-pipecolate pathway.	Lysine	66-71	alanine racemase	Pseudomonas putida KT2440	45-48
30008699-11	2018	This is consistent with a predicted role for Alr in catabolism of l-Lys by virtue of its ability to convert l-Lys to d-Lys, which is further catabolized through the l-pipecolate pathway.	Lysine	108-113	alanine racemase	Pseudomonas putida KT2440	45-48
31544977-8	2020	Mechanistically, AGG-induced cytoplasmic SIRT1 deacetylated a Lys residue on the cytoplasmic domain of lysosome-associated membrane protein 1 (LAMP1), an autolysosomal protein, resulting in lipophagy and senescence.	Lysine	62-65	lysosomal associated membrane protein 1	Homo sapiens	143-148
29950655-4	2018	We also investigated XLF residues required for EJ without indels, finding that one of two binding domains is essential (L115 or C-terminal lysines that bind XRCC4 and KU/DNA, respectively), and that disruption of one of these domains sensitizes XLF to mutations that affect its dimer interface, which we examined with molecular dynamic simulations.	Lysine	139-146	X-ray repair cross complementing 4	Homo sapiens	157-162
31911441-0	2020	An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.	Lysine	93-99	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	25-30
29998111-5	2018	It is efficiently inhibited by the lysine reagent pyridoxal phosphate and it is not affected by inhibitors of other recognized plasma and mitochondrial membranes ascorbate transporters GLUT1(glucose transporter-1) or SVCT2 (sodium-dependent vitamin C transporter-2).	Lysine	35-41	solute carrier family 23 member 2	Rattus norvegicus	224-264
31911441-3	2020	In the SETD3 active site, Asn255 engages in a unique hydrogen-bonding interaction with the target histidine of actin that likely contributes to its >1300-fold greater catalytic efficiency (k cat/Km ) on histidine than on lysine.	Lysine	221-227	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	7-12
31911441-4	2020	Here, we engineered active-site variants to switch the SETD3 target specificity from histidine to lysine.	Lysine	98-104	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	55-60
31911441-6	2020	The doubly substituted SETD3 variant exhibited a 13-fold preference for lysine over histidine.	Lysine	72-78	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	23-28
31660637-1	2020	BACKGROUND: MLL2 (mixed-lineage leukemia 2) is recognized as an essential role in regulating histone 3 lysine 4 tri-methylation (H3K4me3) in mammalian cells.	Lysine	103-109	lysine methyltransferase 2B	Homo sapiens	12-16
29680657-3	2018	Post-translational modification (i.e., acetylation of lysine residues) of HMGB1 leads to the release of HMGB1 into the cellular space, operating as a warning signal that induces inflammation.	Lysine	54-60	high mobility group box 1	Mus musculus	74-79
29680657-3	2018	Post-translational modification (i.e., acetylation of lysine residues) of HMGB1 leads to the release of HMGB1 into the cellular space, operating as a warning signal that induces inflammation.	Lysine	54-60	high mobility group box 1	Mus musculus	104-109
29920280-4	2018	ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formation, repress transposable elements (TEs), and control genome stability in Arabidopsis.	Lysine	26-32	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	0-7
31660637-1	2020	BACKGROUND: MLL2 (mixed-lineage leukemia 2) is recognized as an essential role in regulating histone 3 lysine 4 tri-methylation (H3K4me3) in mammalian cells.	Lysine	103-109	lysine methyltransferase 2B	Homo sapiens	18-42
29712772-5	2018	Furthermore, we demonstrated that SOCS1- and SOCS3-bound IFN regulatory factor 7, a pivotal transcription factor of the TLR7 pathway, through the SH2 domain to promote its proteasomal degradation by lysine 48-linked polyubiquitination.	Lysine	199-205	suppressor of cytokine signaling 3	Homo sapiens	45-50
32005646-1	2020	The class III histone deacetylase sirtuin 6 (SIRT6) modulates numerous functions in the cell by deacetylating histone lysine residues.	Lysine	118-124	sirtuin 6	Homo sapiens	34-43
29679567-2	2018	Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor growth.	Lysine	23-29	Kruppel like factor 5	Homo sapiens	15-19
32005646-1	2020	The class III histone deacetylase sirtuin 6 (SIRT6) modulates numerous functions in the cell by deacetylating histone lysine residues.	Lysine	118-124	sirtuin 6	Homo sapiens	45-50
32005646-2	2020	Interestingly, SIRT6"s efficiency in in vitro experiments is far greater against substrates carrying long-chain fatty acyl modifications such as myristoylated lysine compared with acetylated counterparts, but the deacetylase activity can be stimulated by fatty acids and small-molecule allosteric modulators.	Lysine	159-165	sirtuin 6	Homo sapiens	15-20
29637793-2	2018	The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups.	Lysine	112-118	sirtuin 5	Homo sapiens	12-17
31743857-3	2020	SAP30BP, a human transcriptional regulatory protein, can increase histone deacetylase activity by regulating the deacetylation levels of lysines 9 and 14 in histone H3.	Lysine	137-144	SAP30 binding protein	Homo sapiens	0-7
29603199-10	2018	Furthermore, deacetylation of CypD at Lys residue by sirtuin 3 (SIRT3) caused its dissociation from ANT, contributing to an increase in mPT threshold in NAD+ -pretreated animals.	Lysine	38-41	peptidylprolyl isomerase F	Rattus norvegicus	30-34
31768548-4	2019	Lys-1 is a region of high charge density in the h-amylin amyloid fiber.	Lysine	0-3	islet amyloid polypeptide	Homo sapiens	50-56
29963106-11	2018	The functional involvement of HDAC3 was related in part to the repression of miR-31 transcription via decreased histone H3 acetylation at lysine K9 levels of the miR-31 promoter.	Lysine	138-144	histone deacetylase 3	Homo sapiens	30-35
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	135-141	E1A binding protein p300	Homo sapiens	53-57
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	135-141	E1A binding protein p300	Homo sapiens	73-78
28815510-3	2018	Acute treatment of SH-SY5Y cells with the GSI LY-374973 (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, DAPT) augments PS1, in parallel with increases in other gamma-secretase subunits nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1, yet with no increase in messenger RNA expression.	Lysine	46-48	presenilin 1	Homo sapiens	143-146
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	135-141	katanin regulatory subunit B1	Homo sapiens	63-66
30856481-1	2019	The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues.	Lysine	336-342	E1A binding protein p300	Homo sapiens	53-57
31276292-5	2019	We further identified that Lys-591 is the critical SUMO-acceptor site of PIPKIgamma and that SUMO conjugation at this site is required for PIPKIgamma-driven keratinocyte migration and growth.	Lysine	27-30	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	Homo sapiens	73-83
29498487-8	2018	Inhibition of Plg-FhbB binding by epsilon-aminocaproic acid (a lysine analog) indicates that binding is mediated by electrostatic interactions that presumably occur with Lys binding sites contained within Plg "Kringle" domains 1, 2, 4 or 5.	Lysine	63-69	plasminogen	Homo sapiens	14-17
29498487-8	2018	Inhibition of Plg-FhbB binding by epsilon-aminocaproic acid (a lysine analog) indicates that binding is mediated by electrostatic interactions that presumably occur with Lys binding sites contained within Plg "Kringle" domains 1, 2, 4 or 5.	Lysine	170-173	plasminogen	Homo sapiens	14-17
29498487-8	2018	Inhibition of Plg-FhbB binding by epsilon-aminocaproic acid (a lysine analog) indicates that binding is mediated by electrostatic interactions that presumably occur with Lys binding sites contained within Plg "Kringle" domains 1, 2, 4 or 5.	Lysine	170-173	plasminogen	Homo sapiens	205-208
31140128-0	2019	Correction to: Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression.	Lysine	76-82	tyrosine aminotransferase	Homo sapiens	15-18
29506078-3	2018	Here we find that METTL3 is modified by SUMO1 mainly at lysine residues K177, K211, K212 and K215, which can be reduced by an SUMO1-specific protease SENP1.	Lysine	56-62	small ubiquitin like modifier 1	Homo sapiens	40-45
29506078-3	2018	Here we find that METTL3 is modified by SUMO1 mainly at lysine residues K177, K211, K212 and K215, which can be reduced by an SUMO1-specific protease SENP1.	Lysine	56-62	small ubiquitin like modifier 1	Homo sapiens	126-131
31649033-9	2019	Molecular modeling and mutagenesis of AKR1A1 identified Arg-312 as a key residue mediating the specific interaction with GSNO; in contrast, substitution of the SNO-CoA-binding residue Lys-127 minimally affected the GSNO-reducing activity of AKR1A1.	Lysine	184-187	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	38-44
29775581-0	2018	p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.	Lysine	14-20	E1A binding protein p300	Homo sapiens	0-4
31784571-3	2019	We demonstrated before that neddylation, a post-translational modification that covalently binds Nedd8 to lysine-residues, strongly affects neuronal maturation and spine stability.	Lysine	106-112	NEDD8 ubiquitin like modifier	Homo sapiens	97-102
29775581-3	2018	We discovered that p300 differentially regulates Khib and Kac on distinct lysine sites, with only 6 of the 149 p300-targeted Khib sites overlapping with the 693 p300-targeted Kac sites.	Lysine	74-80	E1A binding protein p300	Homo sapiens	19-23
29775581-3	2018	We discovered that p300 differentially regulates Khib and Kac on distinct lysine sites, with only 6 of the 149 p300-targeted Khib sites overlapping with the 693 p300-targeted Kac sites.	Lysine	74-80	E1A binding protein p300	Homo sapiens	111-115
29775581-3	2018	We discovered that p300 differentially regulates Khib and Kac on distinct lysine sites, with only 6 of the 149 p300-targeted Khib sites overlapping with the 693 p300-targeted Kac sites.	Lysine	74-80	E1A binding protein p300	Homo sapiens	111-115
29769606-0	2018	Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.	Lysine	31-37	histone H2A	Saccharomyces cerevisiae S288C	16-27
31521505-1	2019	Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27.	Lysine	136-142	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	57-62
29769606-4	2018	Here, we discovered the functions of malonylation in histone H2A at lysine 119 (H2A-K119) in chromosome segregation during mitosis and meiosis.	Lysine	68-74	histone H2A	Saccharomyces cerevisiae S288C	53-64
31176610-5	2019	Recently, methods more specific to l-lysine were developed using newly discovered enzymes such as l-lysine epsilon-oxidase (l-LysOepsilon), l-amino acid oxidase/monooxygenase (l-AAO/MOG) and l-lysine decarboxylase/oxidase (l-Lys-DC/OD).	Lysine	35-43	myelin oligodendrocyte glycoprotein	Homo sapiens	182-185
29745895-1	2018	Early mouse development is regulated and accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2).	Lysine	134-140	euchromatic histone lysine N-methyltransferase 2	Mus musculus	110-113
31176610-9	2019	The l-AAO/MOG has high substrate specificity towards l-lysine; however it exhibits l-lysine oxidase and monooxygenase activities.	Lysine	53-61	myelin oligodendrocyte glycoprotein	Homo sapiens	10-13
29751762-3	2018	RESULTS: Here we show that various lysine and arginine mutations reduce the capacity of Tat to induce both transcription and mRNA splicing.	Lysine	35-41	tyrosine aminotransferase	Homo sapiens	88-91
29751762-4	2018	The lysine 28 and lysine 50 residues of Tat, or the acetylation and methylation modifications of these basic amino acids, were essential for Tat transcriptional control, and also for the proviral expression effects elicited by histone deacetylase inhibitors (HDACi) or the bromodomain inhibitor JQ1.	Lysine	4-10	tyrosine aminotransferase	Homo sapiens	40-43
29751762-4	2018	The lysine 28 and lysine 50 residues of Tat, or the acetylation and methylation modifications of these basic amino acids, were essential for Tat transcriptional control, and also for the proviral expression effects elicited by histone deacetylase inhibitors (HDACi) or the bromodomain inhibitor JQ1.	Lysine	4-10	tyrosine aminotransferase	Homo sapiens	141-144
31176610-9	2019	The l-AAO/MOG has high substrate specificity towards l-lysine; however it exhibits l-lysine oxidase and monooxygenase activities.	Lysine	83-91	myelin oligodendrocyte glycoprotein	Homo sapiens	10-13
29751762-4	2018	The lysine 28 and lysine 50 residues of Tat, or the acetylation and methylation modifications of these basic amino acids, were essential for Tat transcriptional control, and also for the proviral expression effects elicited by histone deacetylase inhibitors (HDACi) or the bromodomain inhibitor JQ1.	Lysine	18-24	tyrosine aminotransferase	Homo sapiens	40-43
29751762-4	2018	The lysine 28 and lysine 50 residues of Tat, or the acetylation and methylation modifications of these basic amino acids, were essential for Tat transcriptional control, and also for the proviral expression effects elicited by histone deacetylase inhibitors (HDACi) or the bromodomain inhibitor JQ1.	Lysine	18-24	tyrosine aminotransferase	Homo sapiens	141-144
31231131-7	2019	Ascl1 regulated Wnt11 expression via lysine H3K27 acetylation at the enhancer region of the WNT11 gene.	Lysine	37-43	achaete-scute family bHLH transcription factor 1	Homo sapiens	0-5
29628311-1	2018	The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3.	Lysine	157-163	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	67-72
31492675-1	2019	The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression.	Lysine	115-121	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	62-67
29499325-7	2018	In addition, YAP recruits polycomb repressive complex 2 (PRC2) to tri-methylate histone H3 lysine 27 in the promoter region of GDF15.	Lysine	91-97	Yes1 associated transcriptional regulator	Homo sapiens	13-16
31502464-5	2019	Modified forms of SUMO1 or SUMO2, with a histidine tag and a Thr to Lys mutation preceding the carboxyl-terminal di-gly motif, were expressed in mpkCCD14 cells, allowing SUMO-conjugated proteins to be purified and identified.	Lysine	68-71	small ubiquitin like modifier 1	Homo sapiens	18-23
29706618-5	2018	We identified ZFP91 as the E3 ubiquitin ligase that is responsible for hnRNP F ubiquitination at Lys 185 and proteasomal degradation.	Lysine	97-100	heterogeneous nuclear ribonucleoprotein F	Homo sapiens	71-78
31687022-8	2019	Per Glu380Lys, Glu with negative charges has been changed into Lys with positive charges, which may affect the hydrogen bond formation between amino acids and the stability of the local structure, thus affecting the binding of zinc iron to MKRN3 protein.	Lysine	10-13	makorin ring finger protein 3	Homo sapiens	240-245
29764918-1	2018	The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans.	Lysine	9-15	ocelliless	Drosophila melanogaster	68-81
29764918-1	2018	The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans.	Lysine	9-15	ocelliless	Drosophila melanogaster	83-86
31107719-3	2019	MPNST frequently harbors inactivating mutations in SUZ12 or EED, resulting in PRC2 dysfunction and loss of histone H3 lysine 27 trimethylation (H3K27me3), most often seen in sporadic and radiation-associated, high-grade tumors; immunohistochemistry (IHC) for H3K27me3 is a useful diagnostic marker.	Lysine	118-124	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	51-56
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	49-55	mechanistic target of rapamycin kinase	Bos taurus	103-107
30728459-12	2019	Furthermore, PGC1beta-OT1 affected the expression of endogenous miR-148a-3p and its target gene lysine-specific demethylase 6b (KDM6B).	Lysine	96-102	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-21
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	49-55	mechanistic target of rapamycin kinase	Bos taurus	114-118
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	57-60	mechanistic target of rapamycin kinase	Bos taurus	103-107
29785899-4	2018	When CMECs were treated with methionine (Met) or lysine (Lys), expression of RagD, beta-casein (CSN2), mTOR and p-mTOR, and cell proliferation were increased.	Lysine	57-60	mechanistic target of rapamycin kinase	Bos taurus	114-118
31388109-2	2019	We identified four patients with childhood-onset IGD harboring novel disease-causing mutations in lysine-specific histone methyltransferase 2B gene (KMT2B) by whole-exome sequencing.	Lysine	98-104	lysine methyltransferase 2B	Homo sapiens	149-154
29514927-8	2018	Moreover, our results indicate that RNF5 autoubiquitination on multiple lysine residues targets it for ubiquitin and VCP--dependent clearance.	Lysine	72-78	valosin containing protein	Homo sapiens	117-120
29511348-3	2018	BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription.	Lysine	38-44	delta/notch like EGF repeat containing	Homo sapiens	0-3
31121257-5	2019	Lys also provoked a reduction of NeuN and synaptophysin, as well as an increase of astrocytic GFAP, in the striatum of Gcdh-/- mice, indicating neuronal loss and astrocyte reactivity.	Lysine	0-3	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	33-37
31121257-7	2019	Finally, it was found that Lys provoked alterations of myelin structure reflected by decreased myelin basic protein (MBP) in the cerebral cortex of Gcdh-/- mice.	Lysine	27-30	myelin basic protein	Mus musculus	95-115
31121257-7	2019	Finally, it was found that Lys provoked alterations of myelin structure reflected by decreased myelin basic protein (MBP) in the cerebral cortex of Gcdh-/- mice.	Lysine	27-30	myelin basic protein	Mus musculus	117-120
29709017-13	2018	The DNA-protein interaction results revealed the importance of core residues (Tyr, Arg, and Lys) in a feasible WRKY-W-box DNA interaction.	Lysine	92-95	LOC100191122	Solanum lycopersicum	111-115
31543513-10	2019	It also suppressed the histone acetyltransferase PCAF-mediated acetylation of lysine 27 in histone 3 (H3K27ac) and decreased the H3K27ac enrichment in CXCL12 promoters.	Lysine	78-84	K(lysine) acetyltransferase 2B	Mus musculus	23-53
31543513-10	2019	It also suppressed the histone acetyltransferase PCAF-mediated acetylation of lysine 27 in histone 3 (H3K27ac) and decreased the H3K27ac enrichment in CXCL12 promoters.	Lysine	78-84	chemokine (C-X-C motif) ligand 12	Mus musculus	151-157
29606589-1	2018	The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2, Suz12, and Eed, and it mediates all di- and tri-methylation of histone H3 at lysine 27 in higher eukaryotes.	Lysine	158-164	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	73-79
29606589-1	2018	The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2, Suz12, and Eed, and it mediates all di- and tri-methylation of histone H3 at lysine 27 in higher eukaryotes.	Lysine	158-164	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	81-86
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	120-123	CYLD lysine 63 deubiquitinase	Mus musculus	91-95
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	120-123	CYLD lysine 63 deubiquitinase	Mus musculus	156-160
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	CYLD lysine 63 deubiquitinase	Mus musculus	91-95
29584949-4	2018	The tool is also used to show that the histone acylation activity of the transcriptional coactivator, p300, can be activated by pre-existing lysine crotonylation through a positive feedback mechanism.	Lysine	141-147	E1A binding protein p300	Homo sapiens	102-106
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	CYLD lysine 63 deubiquitinase	Mus musculus	156-160
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	CYLD lysine 63 deubiquitinase	Mus musculus	91-95
31616951-5	2019	MORC2, in turn, stabilizes PARP1 through enhancing acetyltransferase NAT10-mediated acetylation of PARP1 at lysine 949, which blocks its ubiquitination at the same residue and subsequent degradation by E3 ubiquitin ligase CHFR.	Lysine	108-114	MORC family CW-type zinc finger 2	Homo sapiens	0-5
29692793-5	2018	Here we discuss the potential impact of lysine acetylation on the recently identified nuclear substrate proteins of lysine deacetylases from the Arabidopsis RPD3/HDA1-family.	Lysine	40-46	histone deacetylase 1	Arabidopsis thaliana	162-166
31533203-10	2019	Taken together, our studies suggest that acrolein modification of apoE3 at lysine residues leads to increase in net negative charge, and as a consequence, results in clearance by LOX1 and SRB1 on endothelial cells.	Lysine	75-81	scavenger receptor class B, member 1	Mus musculus	188-192
29334179-5	2018	Using PEG2.4K -p(HEMASN38)3K as a model prodrug, herein an active-targeted strategy decorated with cys-arg-gly-asp-lys (CRGDK), a peptide specifically binds to neuropilin-1 overexpressed by tumor vessels and tumor cells, is successfully established to further improve the delivery and efficacy of SN38.	Lysine	115-118	neuropilin 1	Homo sapiens	160-172
31247190-1	2019	SIRT5 has a wide range of functions in different cellular processes such as glycolysis, TCA cycle and antioxidant defense, which mediates lysine desuccinylation, deglutarylation and demalonylation.	Lysine	138-144	sirtuin 5	Homo sapiens	0-5
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	18-24	histone deacetylase 3	Homo sapiens	0-5
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	18-24	histone deacetylase 3	Homo sapiens	163-168
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	133-139	histone deacetylase 3	Homo sapiens	0-5
31511540-3	2019	Here, we show that DNA damage-induced SMG7-p53 binding requires phosphorylated Ser15 on p53, and that substitution of the conserved lysine residue K66 in the SMG7 14-3-3-like domain with the glutamic acid (E) abolishes interactions with its client proteins p53 and UPF1.	Lysine	132-138	SMG7 nonsense mediated mRNA decay factor	Homo sapiens	158-162
29452418-5	2018	Mechanistically, PHF20 interacts with poly(ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3).	Lysine	289-295	PHD finger protein 20	Homo sapiens	17-22
31280863-4	2019	We also demonstrated that EIF3D is K27-polyubiquitinated at the lysine 153 and 275 residues in a KCTD10-dependent manner in human hepatocellular carcinoma HepG2 cells.	Lysine	64-70	keratin 27	Homo sapiens	35-38
29440709-6	2018	We demonstrated that lysine 830 of BRCA1 is a preferential acetylation site by pCAF and tested its function in embryonic stem (ES) cells by changing lysine 830 to arginine using a transcription activator-like effector nuclease (TALEN) system.	Lysine	21-27	lysine acetyltransferase 2B	Homo sapiens	79-83
31280863-4	2019	We also demonstrated that EIF3D is K27-polyubiquitinated at the lysine 153 and 275 residues in a KCTD10-dependent manner in human hepatocellular carcinoma HepG2 cells.	Lysine	64-70	potassium channel tetramerization domain containing 10	Homo sapiens	97-103
31481081-4	2019	Chromatin immunoprecipitation (ChIP) was performed to investigate the levels of histone H3 lysine 27 trimethylation at the HOXA9 promoters.	Lysine	91-97	homeobox A9	Homo sapiens	123-128
29552180-7	2018	Chromatin immunoprecipitation experiments indicated that SIRT6 directly bound to the CDC25A promoter and decreased the acetylation level of histone H3 lysine 9.	Lysine	151-157	sirtuin 6	Homo sapiens	57-62
29555911-9	2018	Additionally, lysine analogue epsilon-aminocaproic acid inhibits Ixonnexin-mediated plasmin generation implying that lysine-binding sites of Kringle domain(s) of plasminogen or t-PA are involved in this process.	Lysine	14-20	plasminogen	Mus musculus	162-173
29555911-9	2018	Additionally, lysine analogue epsilon-aminocaproic acid inhibits Ixonnexin-mediated plasmin generation implying that lysine-binding sites of Kringle domain(s) of plasminogen or t-PA are involved in this process.	Lysine	14-20	plasminogen activator, tissue	Mus musculus	177-181
29555911-9	2018	Additionally, lysine analogue epsilon-aminocaproic acid inhibits Ixonnexin-mediated plasmin generation implying that lysine-binding sites of Kringle domain(s) of plasminogen or t-PA are involved in this process.	Lysine	117-123	plasminogen	Mus musculus	162-173
29555911-9	2018	Additionally, lysine analogue epsilon-aminocaproic acid inhibits Ixonnexin-mediated plasmin generation implying that lysine-binding sites of Kringle domain(s) of plasminogen or t-PA are involved in this process.	Lysine	117-123	plasminogen activator, tissue	Mus musculus	177-181
31291816-3	2019	This review describes several ways of how lysine-specific PTMs are used by various viruses to ensure its successful invasion and replication.	Lysine	42-48	parathymosin	Homo sapiens	58-62
29414787-0	2018	Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.	Lysine	53-59	ubiquitin conjugating enzyme E2 D1	Homo sapiens	0-34
29414787-0	2018	Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.	Lysine	53-59	ubiquitin conjugating enzyme E2 D1	Homo sapiens	36-42
31207107-3	2019	In particular, the lysine-specific demethylase KDM1A/LSD1 is linked to transcriptional regulation of target genes orchestrated by the EWS portion of the fusion protein interacting with repressive chromatin-remodeling complexes.	Lysine	19-25	EWS RNA binding protein 1	Homo sapiens	134-137
29414787-0	2018	Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.	Lysine	53-59	membrane associated ring-CH-type finger 1	Homo sapiens	114-121
29414787-5	2018	Here we confirmed that, although March-I is ubiquitinated, it is not ubiquitinated on a lysine residue, as a lysine-less March-I variant was ubiquitinated similarly as wildtype March-I.	Lysine	109-115	membrane associated ring-CH-type finger 1	Homo sapiens	121-128
29414787-5	2018	Here we confirmed that, although March-I is ubiquitinated, it is not ubiquitinated on a lysine residue, as a lysine-less March-I variant was ubiquitinated similarly as wildtype March-I.	Lysine	109-115	membrane associated ring-CH-type finger 1	Homo sapiens	121-128
29414787-8	2018	Taken together, our results suggest that March-I undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with Ube2D1, regulates March-I expression.	Lysine	59-65	membrane associated ring-CH-type finger 1	Homo sapiens	41-48
29414787-8	2018	Taken together, our results suggest that March-I undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with Ube2D1, regulates March-I expression.	Lysine	59-65	ubiquitin conjugating enzyme E2 D1	Homo sapiens	159-165
29414787-8	2018	Taken together, our results suggest that March-I undergoes lysine-independent ubiquitination by an as yet unidentified E3 ubiquitin ligase that, together with Ube2D1, regulates March-I expression.	Lysine	59-65	membrane associated ring-CH-type finger 1	Homo sapiens	177-184
31470857-7	2019	The lysine analogue 6-aminohexanoic acid which blocks the lysine binding sites (LBS), and carboxypeptidase B (CpB) which cleaves carboxy-terminal lysine residues, abolished apo(a)-induced ROS and MMP-9 production, highlighting an effect mediated by apo(a) lysing-binding sites.	Lysine	4-10	lipoprotein(a)	Homo sapiens	173-179
31278053-5	2019	HAT1 expression was critical for S-phase progression and maintenance of H3 lysine 9 acetylation at proliferation-associated genes, including histone genes.	Lysine	75-81	histone acetyltransferase 1	Homo sapiens	0-4
29429936-4	2018	Mutating lysine at position 10 or lysine at position 11 of PSD-95 to glutamate, or glutamate at position 53 or glutamate and aspartate at positions 213 and 217 of alpha-actinin, respectively, to lysine impairs, in parallel, PSD-95 binding to alpha-actinin and postsynaptic localization of PSD-95 and AMPARs.	Lysine	9-15	discs large MAGUK scaffold protein 4	Homo sapiens	59-65
29429936-4	2018	Mutating lysine at position 10 or lysine at position 11 of PSD-95 to glutamate, or glutamate at position 53 or glutamate and aspartate at positions 213 and 217 of alpha-actinin, respectively, to lysine impairs, in parallel, PSD-95 binding to alpha-actinin and postsynaptic localization of PSD-95 and AMPARs.	Lysine	34-40	discs large MAGUK scaffold protein 4	Homo sapiens	59-65
29429936-4	2018	Mutating lysine at position 10 or lysine at position 11 of PSD-95 to glutamate, or glutamate at position 53 or glutamate and aspartate at positions 213 and 217 of alpha-actinin, respectively, to lysine impairs, in parallel, PSD-95 binding to alpha-actinin and postsynaptic localization of PSD-95 and AMPARs.	Lysine	34-40	discs large MAGUK scaffold protein 4	Homo sapiens	59-65
31439846-1	2019	Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification deposited by the Set2 methyltransferases.	Lysine	11-17	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	96-100
29226977-2	2018	Besides a chain of Ig domains, cardiac titin also contains a proline (P), glutamate (E), valine (V), lysine (K) (PEVK) domain and a cardiac-specific N2B domain, both are largely unstructured.	Lysine	101-107	titin	Homo sapiens	39-44
31186351-4	2019	Our analysis identified the E3 ubiquitin ligases ring finger protein 20 (RNF20) and RNF40, factors that in nonpancreatic cells regulate transcription through imparting monoubiquitin marks on histone H2B (H2Bub1), a precursor to histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	239-245	ring finger protein 20	Mus musculus	49-71
31186351-4	2019	Our analysis identified the E3 ubiquitin ligases ring finger protein 20 (RNF20) and RNF40, factors that in nonpancreatic cells regulate transcription through imparting monoubiquitin marks on histone H2B (H2Bub1), a precursor to histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	239-245	ring finger protein 20	Mus musculus	73-78
29246957-4	2018	I-BET 762 is a new bromodomain inhibitor that reversibly targets BET (bromodomain and extraterminal) proteins and impairs their ability to bind to acetylated lysines on histones, thus interrupting downstream transcription.	Lysine	158-165	delta/notch like EGF repeat containing	Homo sapiens	2-5
31197036-3	2019	A previous study has shown that acetylation of ACLY at Lys-540, Lys-546, and Lys-554 (ACLY-3K) increases ACLY protein stability by antagonizing its ubiquitylation, thereby promoting lipid synthesis and cell proliferation in lung cancer cells.	Lysine	55-58	ATP citrate lyase	Mus musculus	47-51
31197036-3	2019	A previous study has shown that acetylation of ACLY at Lys-540, Lys-546, and Lys-554 (ACLY-3K) increases ACLY protein stability by antagonizing its ubiquitylation, thereby promoting lipid synthesis and cell proliferation in lung cancer cells.	Lysine	55-58	ATP citrate lyase	Mus musculus	86-90
28265857-11	2018	Chromatin immunoprecipitation assay revealed increased trimethylation of histone 3 at lysine 27 (H3K27me3) at the promoter region of the HTR2A gene in the STR.	Lysine	86-92	5-hydroxytryptamine receptor 2A	Rattus norvegicus	137-142
31197036-3	2019	A previous study has shown that acetylation of ACLY at Lys-540, Lys-546, and Lys-554 (ACLY-3K) increases ACLY protein stability by antagonizing its ubiquitylation, thereby promoting lipid synthesis and cell proliferation in lung cancer cells.	Lysine	64-67	ATP citrate lyase	Mus musculus	47-51
31197036-3	2019	A previous study has shown that acetylation of ACLY at Lys-540, Lys-546, and Lys-554 (ACLY-3K) increases ACLY protein stability by antagonizing its ubiquitylation, thereby promoting lipid synthesis and cell proliferation in lung cancer cells.	Lysine	64-67	ATP citrate lyase	Mus musculus	47-51
31066329-4	2019	IPMK enhances autophagy-related transcription by stimulating AMPK-dependent SIRT1 activation, which mediates the deacetylation of histone 4 lysine 16.	Lysine	140-146	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
29335521-5	2018	Further analysis indicated that lysine 147 was a key site for the binding of PFKBFB3 to CDK4.	Lysine	32-38	cyclin dependent kinase 4	Homo sapiens	88-92
29335521-7	2018	The proteasome-dependent degradation of CDK4 was accelerated by disrupting the interaction of PFKFB3 with CDK4 by mutating lysine (147) to alanine.	Lysine	123-129	cyclin dependent kinase 4	Homo sapiens	40-44
29335521-7	2018	The proteasome-dependent degradation of CDK4 was accelerated by disrupting the interaction of PFKFB3 with CDK4 by mutating lysine (147) to alanine.	Lysine	123-129	cyclin dependent kinase 4	Homo sapiens	106-110
31368599-3	2019	MITOL promotes K63-linked chain ubiquitination of IRE1alpha at lysine 481 (K481), thereby preventing hyper-oligomerization of IRE1alpha and regulated IRE1alpha-dependent decay (RIDD).	Lysine	63-69	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	50-59
30811038-12	2019	AURKA interference can reverse the reactive oxygen species elevation caused by SOD2 overexpression or lysine-48 (K48) mutation, respectively, leading to mitochondrial dysfunction.	Lysine	102-108	aurora kinase A	Homo sapiens	0-5
29541639-8	2018	The kinetic behavior of the acetylated protein form nearly mimicked that obtained with a K57/401Q double substitution variant providing an indication that acetylation of the active site-flanking lysine residues can act to reversibly modulate PDI activity.	Lysine	195-201	prolyl 4-hydroxylase subunit beta	Homo sapiens	242-245
29416026-2	2018	Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring.	Lysine	65-71	sirtuin 5	Homo sapiens	32-40
29416026-2	2018	Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring.	Lysine	65-71	sirtuin 5	Homo sapiens	42-47
31165786-2	2019	We identified four patients with childhood-onset IGD harboring novel disease-causing mutations in lysine-specific histone methyltransferase 2B gene (KMT2B) by whole-exome sequencing.	Lysine	98-104	lysine methyltransferase 2B	Homo sapiens	149-154
29425510-5	2018	Structure-function analyses revealed similar N-C interaction in TRPP2 as well as TRPM8/-V1/-C4 via highly conserved tryptophan and lysine/arginine residues.	Lysine	131-137	transient receptor potential cation channel subfamily M member 8	Homo sapiens	81-86
31362455-9	2019	The enzyme had a maximum activity at 37  C, pH 7.4-7.8 and thermal stability for 20 h at 37  C, and 90 days storage stability at 4  C. A. terreus ODC had a maximum affinity (Km) for l-ornithine, l-lysine and l-arginine (0.95, 1.34 and 1.4 mM) and catalytic efficiency (kcat/Km) (4.6, 2.83, 2.46 x 10-5 mM-1 s-1).	Lysine	195-203	ornithine decarboxylase 1	Homo sapiens	146-149
29144959-7	2018	Encapsulation of Aldh1a1-/- adipocytes into alginate poly-L-lysine microcapsules induced functional innervation of adipose tissue in obese wild-type mice.	Lysine	53-66	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	17-24
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	72-75	calcium binding and coiled-coil domain 2	Homo sapiens	145-150
29233643-4	2018	Here, we report that SIRT6 deacetylates lysine 382 of p53 in short synthetic peptide sequence and in full length p53.	Lysine	40-46	sirtuin 6	Homo sapiens	21-26
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	72-75	keratin 27	Homo sapiens	30-33
29167269-8	2018	In addition, RNF126 overexpression consistently results in the loss of RNF168-mediated H2A monoubiquitination at lysine 13/15 and inhibition of the non-homologous end joining capability.	Lysine	113-119	ring finger protein 168	Homo sapiens	71-77
31304625-6	2019	Specifically, RNF34 initiates the K63- to K27-linked ubiquitination transition on MAVS primarily at Lys 311, which facilitates the autophagic degradation of MAVS upon RIG-I stimulation.	Lysine	100-103	keratin 27	Homo sapiens	42-45
31294688-4	2019	During the activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcriptional activator BMAL1 leading to recruitment of BRD4 and the pause release factor P-TEFb, followed by productive elongation of circadian transcripts.	Lysine	56-62	K(lysine) acetyltransferase 5	Mus musculus	81-86
29111742-7	2018	These findings suggest that the acetylation and methylation of lysine on MBP are PTMs associated with the neurological disability produced by EAE.	Lysine	63-69	myelin basic protein	Mus musculus	73-76
28821999-6	2018	Decreased receptor of advanced glycation end products (RAGE) immunocontent supports the assumption that downregulated RAGE/Erk1/2 pathway could be involved in hypophosphorylated lysine/serine/proline (KSP) repeats on neurofilament subunits and disturbed axonal transport.	Lysine	178-184	mitogen activated protein kinase 3	Rattus norvegicus	123-129
31043422-10	2019	SCML2-associated mono-ubiquitylation of histone H2A lysine 119 (H2AK119ub1) and acetylation of histone lysine 27 (H3K27ac) are elevated in Brg1cKO testes.	Lysine	52-58	Scm polycomb group protein like 2	Homo sapiens	0-5
29175209-9	2018	The histone lysine 9 acetylation (acH3K9) level was decreased in PPAR-gamma promoter in high-fructose group but elevated when intake with low concentration alcohol.	Lysine	12-18	peroxisome proliferator activated receptor gamma	Mus musculus	65-75
30995416-6	2019	In addition to defective DNA methylation, histone modification was affected during oogenesis, with UHRF1-null germinal vesicle and metaphase II-stage oocytes exhibiting reduced global histone H3 lysine 9 dimethylation levels and elevated acetylation of histone H4 lysine 12.	Lysine	195-201	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	99-104
29863080-5	2018	However, the lysine residues of Herp, which are ubiquitinated by E3 ubiquitin ligase, were not sufficient for regulation of Herp degradation.	Lysine	13-19	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	32-36
30995416-6	2019	In addition to defective DNA methylation, histone modification was affected during oogenesis, with UHRF1-null germinal vesicle and metaphase II-stage oocytes exhibiting reduced global histone H3 lysine 9 dimethylation levels and elevated acetylation of histone H4 lysine 12.	Lysine	264-270	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	99-104
29503861-9	2018	The aim of this work was to optimize the labeling of [18F]AlF-[GLU-UREA-LYS(AHX)-HBED-CC] in a Tracerlab FXFN  (GE) platform.	Lysine	72-75	afamin	Homo sapiens	58-61
30345869-11	2018	Distinct N-terminal cysteine and lysine residues seemed to mediate gating of TRPA1, although the electrophile scavenger N-acetyl-L-cysteine did not prevent its activation by etomidate.	Lysine	33-39	transient receptor potential cation channel subfamily A member 1	Homo sapiens	77-82
31060926-6	2019	Mutagenesis studies were conducted in a cellular model to assess the impact of acetylation lysine sites on UCP1 function.	Lysine	91-97	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	107-111
31160585-0	2019	Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.	Lysine	0-6	superoxide dismutase 2	Homo sapiens	30-35
29042441-4	2017	Here, we show that TCF19 selectively interacts with histone 3 lysine 4 trimethylation through its plant homeodomain finger.	Lysine	62-68	transcription factor 19	Homo sapiens	19-24
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	24-30	OTU deubiquitinase 1	Homo sapiens	10-15
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	72-78	OTU deubiquitinase 1	Homo sapiens	10-15
29912608-1	2019	Methyltransferase G9a is essential for a key gene silencing mark, histone H3 dimethylation at lysine-9 (H3K9me2).	Lysine	94-100	euchromatic histone lysine N-methyltransferase 2	Mus musculus	18-21
29055779-7	2017	We could show that UHRF1 ubiquitinates PAF15 at Lys 15 and Lys 24 and promotes its binding to PCNA during late S-phase.	Lysine	48-51	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	19-24
29055779-7	2017	We could show that UHRF1 ubiquitinates PAF15 at Lys 15 and Lys 24 and promotes its binding to PCNA during late S-phase.	Lysine	59-62	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	19-24
31146494-8	2019	The antibody specific to CA IX was linked via an amidic bond to the poly-L-lysine modified magnetic nanoparticles, which were conjugated to GO platform again via an amidic bond.	Lysine	68-81	carbonic anhydrase 9	Homo sapiens	25-30
29220657-2	2017	Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2.	Lysine	99-105	protein regulator of cytokinesis 1	Homo sapiens	49-53
29220657-2	2017	Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2.	Lysine	99-105	protein regulator of cytokinesis 1	Homo sapiens	157-161
30942586-2	2019	NPC1 is believed to act in tandem with NPC2, transferring cholesterol and other sterols out of the LE/Lys compartments.	Lysine	102-105	NPC intracellular cholesterol transporter 2	Homo sapiens	39-43
29160868-3	2017	In the present work, lysine (Lys)-based adsorbents were prepared for the specific capture of Plg through the covalent binding of Lys with a polymer monolithic substrate.	Lysine	21-27	plasminogen	Homo sapiens	93-96
29160868-3	2017	In the present work, lysine (Lys)-based adsorbents were prepared for the specific capture of Plg through the covalent binding of Lys with a polymer monolithic substrate.	Lysine	29-32	plasminogen	Homo sapiens	93-96
29160868-3	2017	In the present work, lysine (Lys)-based adsorbents were prepared for the specific capture of Plg through the covalent binding of Lys with a polymer monolithic substrate.	Lysine	129-132	plasminogen	Homo sapiens	93-96
28841214-2	2017	Methylation at lysine (K) 810, which occurs within a critical CDK phosphorylation site and antagonises a CDK-dependent phosphorylation event at the neighbouring S807 residue, acts to hold pRb in the hypo-phosphorylated growth-suppressing state.	Lysine	15-21	RB transcriptional corepressor 1	Homo sapiens	188-191
30962575-0	2019	A complex containing lysine-acetylated actin inhibits the formin INF2.	Lysine	21-27	inverted formin, FH2 and WH2 domain containing	Mus musculus	65-69
28974580-4	2017	Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5.	Lysine	35-41	erb-b2 receptor tyrosine kinase 4	Homo sapiens	61-66
30962627-6	2019	CBP/EP300 bromodomain inhibition decreases somatic-specific gene expression, histone H3 lysine 27 acetylation (H3K27Ac) and chromatin accessibility at target promoters and enhancers.	Lysine	88-94	E1A binding protein p300	Homo sapiens	4-9
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	interleukin 1 receptor associated kinase 1	Homo sapiens	77-119
29250163-2	2017	SET domain containing (lysine methyltransferase) 8 (SET8) is the sole lysine methyltransferase that catalyzes the monomethylation of histone H4 lysine 20, and is associated with tumor growth, invasion and metastasis.	Lysine	23-29	lysine methyltransferase 5A	Homo sapiens	52-56
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	interleukin 1 receptor associated kinase 1	Homo sapiens	121-126
31105998-7	2019	Chromatin immunoprecipitation (ChIP) assay indicated that MALAT1 regulated EEF1A1 by altering the histone 3 lysine 4 (H3K4) epigenotype in the gene promoter.	Lysine	108-114	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	75-81
29186677-3	2017	Setd8 is the sole enzyme that can mono-methylate histone H4, lysine 20 and is highly expressed in erythroblasts compared to most other cell types.	Lysine	61-67	lysine methyltransferase 5A	Homo sapiens	0-5
30703481-6	2019	Succinate dehydrogenase complex subunit A (SDHA), which is involved in both the TCA cycle and oxidative phosphorylation, was desuccinylated at lysine 547 in ccRCC.	Lysine	143-149	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	43-47
28977641-2	2017	Acetylation of H4 on lysines 5 and 12 by the HAT1 acetyltransferase is observed late in the histone maturation cascade.	Lysine	21-28	histone acetyltransferase 1	Homo sapiens	45-49
30797067-6	2019	The amino terminal proline residue (P2) and invariant lysine residue (K33) which are critical active sites of tautomerase activity in mammalian MIF were also detected.	Lysine	54-60	macrophage migration inhibitory factor	Homo sapiens	144-147
28722259-6	2017	In TRPV1-transfected HEK293 cells, Orn and Lys (10 mM) evoked Ca2+ influx, which was blocked by ruthenium red, a TRP channel antagonist.	Lysine	43-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	3-8
29107294-7	2017	Tanycytes from mice lacking the Tas1r1 gene had diminished responses to lysine and arginine but not alanine.	Lysine	72-78	taste receptor, type 1, member 1	Mus musculus	32-38
30931944-5	2019	Mechanistically, USP8 directly removes non-classical K63-linked ubiquitin chains from EPG5 at Lysine 252, leading to enhanced interaction between EPG5 and LC3.	Lysine	94-100	ubiquitin specific peptidase 8	Homo sapiens	17-21
28965816-5	2017	Moreover, Tetherin recruits E3 ubiquitin ligase MARCH8 to catalyze K27-linked ubiquitin chains on MAVS at lysine 7, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	106-112	calcium binding and coiled-coil domain 2	Homo sapiens	157-162
28973940-7	2017	Furthermore, MED25 physically and functionally interacts with HISTONE ACETYLTRANSFERASE1 (HAC1), which plays an important role in JA signaling by selectively regulating histone (H) 3 lysine (K) 9 (H3K9) acetylation of MYC2 target promoters.	Lysine	183-189	histone acetyltransferase 1	Homo sapiens	62-88
30631151-2	2019	Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Lys-51 and Lys-195 with small ubiquitin-like modifier (SUMO)-2/3 modification in metastatic prostate cancer.	Lysine	82-85	ubiquitin conjugating enzyme E2 I	Homo sapiens	56-60
28973940-7	2017	Furthermore, MED25 physically and functionally interacts with HISTONE ACETYLTRANSFERASE1 (HAC1), which plays an important role in JA signaling by selectively regulating histone (H) 3 lysine (K) 9 (H3K9) acetylation of MYC2 target promoters.	Lysine	183-189	histone acetyltransferase 1	Homo sapiens	90-94
30631151-2	2019	Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Lys-51 and Lys-195 with small ubiquitin-like modifier (SUMO)-2/3 modification in metastatic prostate cancer.	Lysine	93-96	ubiquitin conjugating enzyme E2 I	Homo sapiens	56-60
28922740-5	2017	Analysis of the PglB crystal structures from Campylobacter lari and the soluble C-terminal domain from C. jejuni suggests a particularly important structural role for the aspartate residue and the two following glycine residues, as well as a more subtle, less defined role for the lysine residue.	Lysine	281-287	epiphycan	Homo sapiens	16-20
30589612-1	2019	Lysyl hydroxylase-2 (LH2) catalyzes the hydroxylation of telopeptidyl lysine residues on collagen, leading to the formation of stable collagen cross-links that connect collagen molecules and stabilize the extracellular matrix.	Lysine	70-76	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-19
28666361-1	2017	Histone acetyltransferase 1 (Hat1) catalyzes the acetylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled chromatin assembly.	Lysine	96-103	histone aminotransferase 1	Mus musculus	0-27
30589612-1	2019	Lysyl hydroxylase-2 (LH2) catalyzes the hydroxylation of telopeptidyl lysine residues on collagen, leading to the formation of stable collagen cross-links that connect collagen molecules and stabilize the extracellular matrix.	Lysine	70-76	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	21-24
28666361-1	2017	Histone acetyltransferase 1 (Hat1) catalyzes the acetylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled chromatin assembly.	Lysine	96-103	histone aminotransferase 1	Mus musculus	29-33
30866966-4	2019	Histone deacetylase 3 (HDAC3) regulates gene expression by removing acetyl groups from lysine residues, as well as has an oncogenic role in apoptosis and contributes to the proliferation of many cancer cells including cholangiocarcinoma (CCA).	Lysine	87-93	histone deacetylase 3	Homo sapiens	0-21
28668706-8	2017	Molecular dynamic simulations also showed that interaction of catalase with curcumin resulted in changes in accessible surface area (ASA) and pKa, two effective parameters of glycation, in potential glycation lysine residues.	Lysine	209-215	catalase	Bos taurus	62-70
30866966-4	2019	Histone deacetylase 3 (HDAC3) regulates gene expression by removing acetyl groups from lysine residues, as well as has an oncogenic role in apoptosis and contributes to the proliferation of many cancer cells including cholangiocarcinoma (CCA).	Lysine	87-93	histone deacetylase 3	Homo sapiens	23-28
30833716-7	2019	Deletions or point mutations identified several lysine residues in different delta-catenin domains involved in PCAF-mediated delta-catenin downregulation.	Lysine	48-54	lysine acetyltransferase 2B	Homo sapiens	111-115
28784659-2	2017	The E2-conjugating enzyme Ubc9 catalyzes the conjugation of SUMOs to epsilon-amino groups of lysine residues in target proteins.	Lysine	93-99	ubiquitin conjugating enzyme E2 I	Homo sapiens	26-30
28784659-3	2017	Attachment of SUMO moieties to internal lysines in Ubc9 itself can further lead to the formation of polymeric SUMO chains.	Lysine	40-47	ubiquitin conjugating enzyme E2 I	Homo sapiens	51-55
30833722-4	2019	Small molecules targeting the reactive lysine residue (Lys907) in IRE1alpha"s RNase domain have been shown to inhibit the cleavage of XBP1 mRNA.	Lysine	39-45	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	66-75
30763986-1	2019	Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes.	Lysine	65-71	SUV39H2 histone lysine methyltransferase	Homo sapiens	0-39
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	RELA proto-oncogene, NF-kB subunit	Homo sapiens	15-18
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	E1A binding protein p300	Homo sapiens	22-26
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	E1A binding protein p300	Homo sapiens	79-83
30763986-1	2019	Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes.	Lysine	65-71	SUV39H2 histone lysine methyltransferase	Homo sapiens	41-48
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	RELA proto-oncogene, NF-kB subunit	Homo sapiens	141-144
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	RELA proto-oncogene, NF-kB subunit	Homo sapiens	141-144
31225515-5	2019	Since ubiquitination precedes proteasomal turnover and mainly occurs on lysine residues of nascent proteins, we systematically mutated individual lysine residues within BMP2 and tested them for enhanced stability.	Lysine	146-152	bone morphogenetic protein 2	Homo sapiens	169-173
28760777-6	2017	An in vitro SUMOylation assay and immunoprecipitation revealed that when SENP1 associated with N1ICD (NOTCH1 intracellular domain), it functions as a deSUMOylase of N1ICD SUMOylation on conserved lysines.	Lysine	196-203	SUMO1/sentrin specific peptidase 1	Mus musculus	73-78
31225515-6	2019	Results revealed that substitutions on four lysine residues within the pro-BMP2 region and three in the mature region increased both BMP2 turnover and extracellular secretion.	Lysine	44-50	bone morphogenetic protein 2	Homo sapiens	75-79
28687409-8	2017	Furthermore, the deacetylase effect of Sirt3 enhanced the MnSOD activity by deacetylation at the lysine 68 residue and therapeutic effect of UCB-MSCs on skin-wound healing was increased by EphB2 activation.	Lysine	97-103	superoxide dismutase 2	Homo sapiens	58-63
31225515-6	2019	Results revealed that substitutions on four lysine residues within the pro-BMP2 region and three in the mature region increased both BMP2 turnover and extracellular secretion.	Lysine	44-50	bone morphogenetic protein 2	Homo sapiens	133-137
30594073-4	2019	Intriguingly, P62 competes with SETD2 to bind histone H3 and then significantly reduces SETD2-binding capacity to substrate histone H3, triggering drastically the reduction of three methylation on histone H3 36th lysine (H3K36me3).	Lysine	213-219	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	32-37
28696214-9	2017	Moreover, the AhR-MTA2 interaction is CA-dependent and results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation.	Lysine	185-191	aryl hydrocarbon receptor	Homo sapiens	14-17
28696214-9	2017	Moreover, the AhR-MTA2 interaction is CA-dependent and results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation.	Lysine	185-191	metastasis associated 1 family member 2	Homo sapiens	18-22
30594073-4	2019	Intriguingly, P62 competes with SETD2 to bind histone H3 and then significantly reduces SETD2-binding capacity to substrate histone H3, triggering drastically the reduction of three methylation on histone H3 36th lysine (H3K36me3).	Lysine	213-219	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	88-93
30672919-0	2019	Lysine-induced swine satellite cell migration is mediated by the FAK pathway.	Lysine	0-6	focal adhesion kinase	Sus scrofa	65-68
27986911-10	2017	Implications: We newly show that subjects with ALDH2 Lys/Lys genotype in a functional polymorphism, rs671, are more likely to quit smoking than those with ALDH2 Glu allele in a Japanese population.	Lysine	53-56	aldehyde dehydrogenase 2 family member	Homo sapiens	47-52
27986911-10	2017	Implications: We newly show that subjects with ALDH2 Lys/Lys genotype in a functional polymorphism, rs671, are more likely to quit smoking than those with ALDH2 Glu allele in a Japanese population.	Lysine	57-60	aldehyde dehydrogenase 2 family member	Homo sapiens	47-52
30672919-10	2019	Moreover, compared with those in the Lys-deficiency group, the proteins in the FAK pathways were reactivated in the Lys-resupplementation group.	Lysine	37-40	focal adhesion kinase	Sus scrofa	79-82
28899474-0	2017	[Effect of glutaryl-CoA dehydrogenase gene silencing and high-concentration lysine on the viability of BRL hepatocytes].	Lysine	76-82	bromodomain containing 1	Homo sapiens	103-106
30672919-11	2019	In conclusion, these findings indicate that the FAK pathway mediates Lys-induced SC migration.	Lysine	69-72	focal adhesion kinase	Sus scrofa	48-51
30783079-5	2019	Dihydroartemisinin control of miR-34a and miR-7 expression leads to inhibition of Axl expression in a process at least partially dependent on regulation of chromatin via methylation of histone H3 lysine 27 residues by Jumonji, AT-rich interaction domain containing 2 (JARID2), and the enhancer of zeste homolog 2.	Lysine	196-202	microRNA 34a	Homo sapiens	30-37
28648598-0	2017	Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.	Lysine	121-129	myelin basic protein	Homo sapiens	0-20
28648598-4	2017	This mechanism involves the binding of t-PA via a lysine-dependent mechanism to the Lys91 residue of the MBP NH2-terminal region Asp82 -Pro99, and the binding of Pg via a lysine-dependent mechanism to the Lys122 residue of the MBP COOH-terminal region Leu109-Gly126.	Lysine	50-56	myelin basic protein	Homo sapiens	105-108
30759120-1	2019	Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues.	Lysine	206-212	sirtuin 5	Mus musculus	0-9
28527696-3	2017	We previously reported that the histone 3 lysine 9 (H3K9) methyltransferase (MTase) G9a is specifically enriched in the tooth mesenchyme during mouse development.	Lysine	42-48	euchromatic histone lysine N-methyltransferase 2	Mus musculus	84-87
30759120-1	2019	Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues.	Lysine	206-212	sirtuin 5	Mus musculus	11-16
28898989-2	2017	Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	200-206	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	31-36
30315770-1	2019	BACKGROUND &amp; AIMS: The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosus, and variants have been associated with Crohn disease (CD).	Lysine	32-38	CYLD lysine 63 deubiquitinase	Mus musculus	27-31
28915666-5	2017	Additionally, AuA is acetylated by ARD1 at lysine residues at positions 75 and 125.	Lysine	43-49	aurora kinase A	Homo sapiens	14-17
28915666-5	2017	Additionally, AuA is acetylated by ARD1 at lysine residues at positions 75 and 125.	Lysine	43-49	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	35-39
30315770-1	2019	BACKGROUND &amp; AIMS: The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosus, and variants have been associated with Crohn disease (CD).	Lysine	32-38	CYLD lysine 63 deubiquitinase	Mus musculus	63-67
28453857-1	2017	Histone H2B lysine 120 mono-ubiquitination (H2Bub1) catalyzed by Rnf20 has been implicated in normal differentiation of embryonic stem (ES) and adult stem cells.	Lysine	12-18	ring finger protein 20	Mus musculus	65-70
30315770-18	2019	We found that sCYLD mediated lysine 63-linked ubiquitination of SMAD7.	Lysine	29-35	SMAD family member 7	Mus musculus	64-69
30443978-4	2019	Mass spectrometry revealed that protein sirtuin 5 (SIRT5) is a binding partner of LDHB that deacetylated LDHB at lysine-329, thereby promoting its enzymatic activity.	Lysine	113-119	sirtuin 5	Homo sapiens	40-49
28486049-7	2017	Mechanistic studies demonstrate that hypoxic insult enhances the interaction of FUNDC1 with MARCH5, which ubiquitinates FUNDC1 at lysine 119 for subsequent degradation.	Lysine	130-136	FUN14 domain containing 1	Homo sapiens	80-86
30443978-4	2019	Mass spectrometry revealed that protein sirtuin 5 (SIRT5) is a binding partner of LDHB that deacetylated LDHB at lysine-329, thereby promoting its enzymatic activity.	Lysine	113-119	sirtuin 5	Homo sapiens	51-56
28486049-7	2017	Mechanistic studies demonstrate that hypoxic insult enhances the interaction of FUNDC1 with MARCH5, which ubiquitinates FUNDC1 at lysine 119 for subsequent degradation.	Lysine	130-136	FUN14 domain containing 1	Homo sapiens	120-126
30696704-7	2019	The analogous lysine-to-alanine substitution in a glutamate-substituted phosphomimetic mutant form of GC-B also reduced enzyme activity, consistent with ATP stimulating guanylyl cyclase activity through an allosteric, phosphorylation-independent mechanism.	Lysine	14-20	natriuretic peptide receptor 2	Homo sapiens	102-106
28032455-1	2017	The bromodomain (BRD) and extra-terminal domain (BET) protein family bind to acetylated histones on lysine residues and act as epigenetic readers.	Lysine	100-106	delta/notch like EGF repeat containing	Homo sapiens	49-52
30445466-5	2019	In addition, we found that 3 NONO lysine residues (positions 279, 290 and 295) are important for conferring its instability in UV-DDR.	Lysine	34-40	non-POU domain containing octamer binding	Homo sapiens	29-33
28665982-3	2017	Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initiate transcriptional repression.	Lysine	54-60	Polycomb	Drosophila melanogaster	0-2
30445466-6	2019	Depletion of RNF8 or expression of NONO with lysine to arginine substitutions at positions 279, 290 and 295 prolonged CHK1 phosphorylation over an extended period of time.	Lysine	45-51	non-POU domain containing octamer binding	Homo sapiens	35-39
30670717-7	2019	We also found that, among 84 different histone modification enzymes, only SET domain bifurcated 2 (Setdb2), one of the histone methyltransferases that methylates the lysine 9 of histone H3, showed significantly higher expression in the IAE group compared with the control group.	Lysine	166-172	SET domain, bifurcated 2	Mus musculus	99-105
27344336-5	2017	On the other hand, MG-H1 levels in patients with HbA1c of &lt;6 and &gt;=6 % was 12.85 and 10.45 mmol/mol Lys, respectively, the difference between which is not significant.	Lysine	106-109	hemoglobin subunit alpha 1	Homo sapiens	49-53
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	centromere protein A	Homo sapiens	22-28
28255013-3	2017	Here we report a novel mechanism of how mDia2 is regulated: through acetylation and deacetylation at lysine 970 in the formin homology 2 domain.	Lysine	101-107	diaphanous related formin 3	Mus musculus	40-45
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	centromere protein A	Homo sapiens	67-73
30679956-9	2019	To further characterize the benefit of methanol as the carbon source, extra NADH from methanol oxidation was engineered to generate NADPH to improve lysine biosynthesis by expression of the POS5 gene from Saccharomyces cerevisiae, which resulted in a twofold improvement of lysine production.	Lysine	149-155	NADH kinase	Saccharomyces cerevisiae S288C	190-194
28474499-1	2017	INTRODUCTION: The BET family of bromodomain-containing proteins constitute epigenetic readers that bind to acetylated lysine residues of core histones, thereby translating epigenetic histone marks to effects on gene expression.	Lysine	118-124	delta/notch like EGF repeat containing	Homo sapiens	18-21
30679956-9	2019	To further characterize the benefit of methanol as the carbon source, extra NADH from methanol oxidation was engineered to generate NADPH to improve lysine biosynthesis by expression of the POS5 gene from Saccharomyces cerevisiae, which resulted in a twofold improvement of lysine production.	Lysine	274-280	NADH kinase	Saccharomyces cerevisiae S288C	190-194
30669413-6	2019	Monoubiquitination of histone H2A at lysine 119 (H2AK119ub1) is also well-studied, its E3 ubiquitin ligase constituting part of thePolycomb Repressor Complex 1 (PRC1), RING1B-BMI1, associated with transcriptional silencing.	Lysine	37-43	protein regulator of cytokinesis 1	Homo sapiens	161-165
28131816-7	2017	Mechanistic studies showed that TRAF1 expression enhances the ubiquitination of ERK5 on lysine 184, which is necessary for its kinase activity and AP-1 activation.	Lysine	88-94	mitogen-activated protein kinase 7	Mus musculus	80-84
30669413-6	2019	Monoubiquitination of histone H2A at lysine 119 (H2AK119ub1) is also well-studied, its E3 ubiquitin ligase constituting part of thePolycomb Repressor Complex 1 (PRC1), RING1B-BMI1, associated with transcriptional silencing.	Lysine	37-43	ring finger protein 2	Homo sapiens	168-174
30669413-6	2019	Monoubiquitination of histone H2A at lysine 119 (H2AK119ub1) is also well-studied, its E3 ubiquitin ligase constituting part of thePolycomb Repressor Complex 1 (PRC1), RING1B-BMI1, associated with transcriptional silencing.	Lysine	37-43	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	175-179
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	214-220	sirtuin 6	Homo sapiens	0-9
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	246-252	sirtuin 6	Homo sapiens	0-9
30472188-4	2019	We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ.	Lysine	40-46	Yes1 associated transcriptional regulator	Homo sapiens	92-95
28542476-7	2017	The mechanism involves association of the Mage A6-MHD domain to MageA11, prevention of MageA11 ubiquitinylation on lysines 240 and 245 and decreased proteasome-dependent degradation.	Lysine	115-122	MAGE family member A11	Homo sapiens	87-94
28108655-0	2017	The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).	Lysine	123-126	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	178-183
28108655-1	2017	Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many non-histone proteins, including eukaryotic elongation factor 1 alpha (eEF1A).	Lysine	0-6	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	222-227
30379096-8	2019	Moreover, SIRT1 can physically interact with HMGB1 at the deacetylated lysine sites K28, K29, and K30, subsequently suppressing downstream inflammatory signaling.	Lysine	71-77	high mobility group box 1	Mus musculus	45-50
28108655-3	2017	We here demonstrate, using a wide range of in vitro and in vivo approaches, that the previously uncharacterized human methyltransferase METTL21B specifically targets Lys-165 in eEF1A in an aminoacyl-tRNA- and GTP-dependent manner.	Lysine	166-169	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	177-182
28108655-7	2017	In summary, the present study identifies METTL21B as the enzyme responsible for methylation of eEF1A on Lys-165 and shows that this modification is dynamic, inducible and likely of regulatory importance.	Lysine	104-107	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	95-100
30509560-0	2019	Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence.	Lysine	94-100	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	23-27
28120412-5	2017	Compared to individuals with Glu/Glu wild-genotype, those with 116Lys rare variants (Lys/Glu+Lys/Lys) had an increased risk of COPD (OR = 3.83, 95% CI: 2.64-5.56; P = 1.45 x 10-12 ).	Lysine	66-69	COPD	Homo sapiens	127-131
28120412-5	2017	Compared to individuals with Glu/Glu wild-genotype, those with 116Lys rare variants (Lys/Glu+Lys/Lys) had an increased risk of COPD (OR = 3.83, 95% CI: 2.64-5.56; P = 1.45 x 10-12 ).	Lysine	85-88	COPD	Homo sapiens	127-131
28120412-5	2017	Compared to individuals with Glu/Glu wild-genotype, those with 116Lys rare variants (Lys/Glu+Lys/Lys) had an increased risk of COPD (OR = 3.83, 95% CI: 2.64-5.56; P = 1.45 x 10-12 ).	Lysine	85-88	COPD	Homo sapiens	127-131
28408745-3	2017	Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression.	Lysine	40-46	C-terminal binding protein 1	Homo sapiens	95-100
28396698-3	2017	In this multidisciplinary report, we utilize in silico computational and in vivo approaches to dissect lysine 124 of human CENP-A, which was previously reported to be acetylated in advance of replication.	Lysine	103-109	centromere protein A	Homo sapiens	123-129
28084329-3	2017	EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1.	Lysine	171-177	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	207-215
28324105-8	2017	At the Mc4r promoter, offspring of HFD-fed mothers demonstrated increased histone 3 lysine 27 acetylation (H3K27ac) with a greater association to thyroid hormone receptor-beta (TRbeta), an inhibitor of Mc4r transcription.	Lysine	84-90	thyroid hormone receptor beta	Rattus norvegicus	177-183
28400503-4	2017	However, lack of skeletal muscle PGC-1alpha reduced SIRT3 protein content, increased total lysine PDH-E1alpha acetylation in the fed state, and prevented a fasting-induced increase in SIRT3 protein.	Lysine	91-97	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	33-43
28345603-5	2017	Interestingly, several different lysine residues in Tat can function as ubiquitin acceptor sites, and variable combinations of these lysines support both full transcriptional activity and viral replication.	Lysine	33-39	tyrosine aminotransferase	Homo sapiens	52-55
28345603-5	2017	Interestingly, several different lysine residues in Tat can function as ubiquitin acceptor sites, and variable combinations of these lysines support both full transcriptional activity and viral replication.	Lysine	133-140	tyrosine aminotransferase	Homo sapiens	52-55
28345603-6	2017	Further, the polyubiquitin chain conjugated to Tat by PJA2 can itself be assembled through variable ubiquitin lysine linkages.	Lysine	110-116	tyrosine aminotransferase	Homo sapiens	47-50
28154185-6	2017	Silencing of HP1gamma expression markedly decreased repressive histone marks and the multimethylation of histone H3 lysine 9 and H4 lysine 20, leading to a significant decrease in DNA methylation at the proximal promoter of the epsilon-globin gene and greatly increased epsilon-globin expression.	Lysine	116-122	chromobox 3	Homo sapiens	13-21
28154185-6	2017	Silencing of HP1gamma expression markedly decreased repressive histone marks and the multimethylation of histone H3 lysine 9 and H4 lysine 20, leading to a significant decrease in DNA methylation at the proximal promoter of the epsilon-globin gene and greatly increased epsilon-globin expression.	Lysine	132-138	chromobox 3	Homo sapiens	13-21
28104734-5	2017	MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.	Lysine	71-77	FUN14 domain containing 1	Homo sapiens	31-37
28098854-7	2017	This is because the inhibition of LSD1 induces dimethylation of lysine 9 on histone H3 (H3K9m2) accumulation at the promoter region of cyclin D1.	Lysine	64-70	cyclin D1	Homo sapiens	135-144
28122963-5	2017	By repairing the deletion, we resurrected 11 alleles of KIR2DP1F , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1F with lysine 44 recognized C1+HLA-C, whereas T44-KIR2DP1F recognized C2+HLA-C.	Lysine	141-147	killer cell immunoglobulin like receptor, two Ig domains pseudogene 1	Homo sapiens	56-63
28122963-5	2017	By repairing the deletion, we resurrected 11 alleles of KIR2DP1F , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1F with lysine 44 recognized C1+HLA-C, whereas T44-KIR2DP1F recognized C2+HLA-C.	Lysine	141-147	killer cell immunoglobulin like receptor, two Ig domains pseudogene 1	Homo sapiens	96-103
27994014-5	2017	Positive charges of acetylable lysine residues in the N-terminal domain of APE1 are essential for chromatin association.	Lysine	31-37	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	75-79
27994014-6	2017	Acetylation-mediated neutralization of the positive charges of the lysine residues in the N-terminal domain of APE1 induces a conformational change; this in turn enhances the AP endonuclease activity of APE1.	Lysine	67-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	111-115
27994014-6	2017	Acetylation-mediated neutralization of the positive charges of the lysine residues in the N-terminal domain of APE1 induces a conformational change; this in turn enhances the AP endonuclease activity of APE1.	Lysine	67-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	203-207
27869166-6	2017	SKP2 knockdown decreased EZH2 levels in human PCa cells through upregulation of TRAF6-mediated and lysine(K) 63-linked ubiquitination of EZH2 for degradation.	Lysine	99-105	S-phase kinase associated protein 2	Homo sapiens	0-4
27815826-5	2017	The mechanism of IRF3 activation in RIPA is distinct from that of transcriptional activation; it requires linear polyubiquitination of specific lysine residues of IRF3.	Lysine	144-150	interferon regulatory factor 3	Mus musculus	17-21
27815826-5	2017	The mechanism of IRF3 activation in RIPA is distinct from that of transcriptional activation; it requires linear polyubiquitination of specific lysine residues of IRF3.	Lysine	144-150	interferon regulatory factor 3	Mus musculus	163-167
27761696-0	2017	Histone methyltransferase TXR1 is required for both H3 and H3.3 lysine 27 methylation in the well-known ciliated protist Tetrahymena thermophila.	Lysine	64-70	Protein Transporter, Pam16	Arabidopsis thaliana	26-30
28073915-0	2017	UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.	Lysine	86-89	H2A clustered histone 18	Homo sapiens	79-82
28073915-3	2017	We demonstrate that UbE2E1 is critical for the monoubiquitination of H2A at residue Lys-119 (uH2AK119) through its association with the PRC1 complex.	Lysine	84-87	H2A clustered histone 18	Homo sapiens	69-72
28073915-9	2017	This study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys-119 monoubiquitination.	Lysine	134-137	H2A clustered histone 18	Homo sapiens	130-133
28261115-8	2017	The triplet puzzle theory also suggests the formation of putative D2R-CCR2, D2R-CXCR4, and D2R-IL1R2 heteromers in mild neuroinflammation in view of their demonstrated sets of Leu-Tyr-Ser (LYS), Leu-Pro-Phe (LPF), and/or Ser-Leu-Ala (SLA) triplet homologies.	Lysine	189-192	dopamine receptor D2	Homo sapiens	66-69
28261115-8	2017	The triplet puzzle theory also suggests the formation of putative D2R-CCR2, D2R-CXCR4, and D2R-IL1R2 heteromers in mild neuroinflammation in view of their demonstrated sets of Leu-Tyr-Ser (LYS), Leu-Pro-Phe (LPF), and/or Ser-Leu-Ala (SLA) triplet homologies.	Lysine	189-192	interleukin 1 receptor type 2	Homo sapiens	95-100
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Lysine	237-243	solute carrier family 3 member 1	Homo sapiens	97-103
28039048-6	2017	Chromatin immunoprecipitation assays suggest the requirement of SH2B1 for the induction of histone H3 lysine 4 trimethylation as well as the reduction of histone H3 lysine 9 trimethylation at the promoters and/or enhancers of IGF2 and MYOG genes during myogenesis.	Lysine	102-108	SH2B adaptor protein 1	Homo sapiens	64-69
27148961-9	2017	These results suggested that Parkin directly ubiquitinated N-terminal Lys residues in APE1 in the cytoplasm.	Lysine	70-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	86-90
27727493-5	2017	Although the GLK activation loop mutant crystallized demonstrates reduced kinase activity, its structure demonstrates all the hallmarks of an "active" kinase, including the salt bridge between the C-helix glutamate and the catalytic lysine.	Lysine	233-239	mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens	13-16
27733505-4	2017	Mechanistically, the TET1 facilitated chromatin affinity and enzymatic activity of hMOF against acetylation of histone H4 at lysine 16 via preventing auto-acetylation of hMOF, to regulate expression of the downstream genes, including DNA repair genes.	Lysine	125-131	lysine acetyltransferase 8	Homo sapiens	83-87
27733505-4	2017	Mechanistically, the TET1 facilitated chromatin affinity and enzymatic activity of hMOF against acetylation of histone H4 at lysine 16 via preventing auto-acetylation of hMOF, to regulate expression of the downstream genes, including DNA repair genes.	Lysine	125-131	lysine acetyltransferase 8	Homo sapiens	170-174
28959869-4	2017	The chromophoric groups, the changes of secondary structure and the molecular docking simulations revealed that the active pocket formed by Cys281-Lys-Asn-Lys-Glu-Lys-Lys287 and Leu313-Ala-Phe-Trp316 of P.rbeta2-GPI-DV and the -COOH carboxyl of oxLig-1 were the key for binding.	Lysine	147-150	glucose-6-phosphate isomerase	Homo sapiens	212-215
28959869-4	2017	The chromophoric groups, the changes of secondary structure and the molecular docking simulations revealed that the active pocket formed by Cys281-Lys-Asn-Lys-Glu-Lys-Lys287 and Leu313-Ala-Phe-Trp316 of P.rbeta2-GPI-DV and the -COOH carboxyl of oxLig-1 were the key for binding.	Lysine	155-158	glucose-6-phosphate isomerase	Homo sapiens	212-215
28959869-4	2017	The chromophoric groups, the changes of secondary structure and the molecular docking simulations revealed that the active pocket formed by Cys281-Lys-Asn-Lys-Glu-Lys-Lys287 and Leu313-Ala-Phe-Trp316 of P.rbeta2-GPI-DV and the -COOH carboxyl of oxLig-1 were the key for binding.	Lysine	155-158	glucose-6-phosphate isomerase	Homo sapiens	212-215
28005340-0	2017	Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase beta with Unnatural Lysine Analogues.	Lysine	127-133	DNA polymerase beta	Homo sapiens	92-111
28005340-5	2017	In the presence of a misacylated tRNACUA transcript, suppression of the UAG codon in the transcribed mRNA led to elaboration of full length Pol beta having a lysine analogue at position 72.	Lysine	158-164	DNA polymerase beta	Homo sapiens	140-148
27679476-3	2017	Here we show that histone H3 lysine 9 demethylase Kdm4d regulates DNA replication in eukaryotic cells.	Lysine	29-35	lysine demethylase 4D	Homo sapiens	50-55
27852821-2	2017	In this study, we investigated the molecular mechanism for the recruitment of Polycomb repressive complex-2 (PRC2) and its accessory component, JARID2, to chromatin, which regulates methylation of lysine 27 of histone H3 (H3K27), during epithelial-mesenchymal transition (EMT) of cancer cells.	Lysine	197-203	jumonji and AT-rich interaction domain containing 2	Homo sapiens	144-150
27733358-6	2017	Subsequent chromatin immunoprecipitation-based analyses indicated that action of 2 of these compounds was associated with lowered levels of the transcriptionally repressive lysine 9-trimethylated histone H3 mark at the CD19 promoter.	Lysine	173-179	CD19 molecule	Homo sapiens	219-223
27292261-2	2017	BET proteins regulate transcription by selectively recognizing acetylated lysine residues on chromatin.	Lysine	74-80	delta/notch like EGF repeat containing	Homo sapiens	0-3
27821436-0	2017	Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.	Lysine	11-17	solute carrier family 47 member 2	Homo sapiens	136-169
27821436-0	2017	Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.	Lysine	36-42	solute carrier family 47 member 2	Homo sapiens	136-169
27821436-0	2017	Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.	Lysine	36-42	solute carrier family 47 member 2	Homo sapiens	136-169
27821436-4	2017	Little is known about the regulation mechanism of SLC47A2 We found that it was a bivalent gene that was enriched with both histone H3 lysine 4 trimethylation (H3K4me3) and lysine 27 trimethylation (H3K27me3).	Lysine	134-140	solute carrier family 47 member 2	Homo sapiens	50-57
27821436-4	2017	Little is known about the regulation mechanism of SLC47A2 We found that it was a bivalent gene that was enriched with both histone H3 lysine 4 trimethylation (H3K4me3) and lysine 27 trimethylation (H3K27me3).	Lysine	172-178	solute carrier family 47 member 2	Homo sapiens	50-57
27821436-6	2017	Histone H3 lysine 27 acetylation also contributed to the expression of SLC47A2 An E2F1-histone deacetylase 10 complex catalyzed deacetylation of H3K27, then prevented the enrichment of H3K4me3, and finally reduced SLC47A2 expression.	Lysine	11-17	solute carrier family 47 member 2	Homo sapiens	71-78
27821436-6	2017	Histone H3 lysine 27 acetylation also contributed to the expression of SLC47A2 An E2F1-histone deacetylase 10 complex catalyzed deacetylation of H3K27, then prevented the enrichment of H3K4me3, and finally reduced SLC47A2 expression.	Lysine	11-17	solute carrier family 47 member 2	Homo sapiens	214-221
28396876-0	2017	Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.	Lysine	19-25	SUV39H2 histone lysine methyltransferase	Homo sapiens	130-137
28396876-11	2017	The expression of histone methyltransferase SUV39H2 for H3 lysine 9 methylation was downregulated in LADA patients, and the expression of histone demethylase KDM4C which made H3 lysine 9 demethylation was upregulated.	Lysine	59-65	SUV39H2 histone lysine methyltransferase	Homo sapiens	44-51
28396876-11	2017	The expression of histone methyltransferase SUV39H2 for H3 lysine 9 methylation was downregulated in LADA patients, and the expression of histone demethylase KDM4C which made H3 lysine 9 demethylation was upregulated.	Lysine	178-184	SUV39H2 histone lysine methyltransferase	Homo sapiens	44-51
28396876-13	2017	The reduction of histone H3 lysine 9 methylation which may due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C was found in CD4+ T lymphocytes of LADA patients.	Lysine	28-34	SUV39H2 histone lysine methyltransferase	Homo sapiens	106-113
29617095-1	2017	In the present study, we evaluated the potential of poly-l-lysine/hyaluronic acid (HA/PLL) hydrogels containing curcumin (CUR) and bone morphogenetic protein-2 (BMP-2) as bone tissue regeneration scaffolds.	Lysine	52-65	bone morphogenetic protein 2	Homo sapiens	131-159
29617095-1	2017	In the present study, we evaluated the potential of poly-l-lysine/hyaluronic acid (HA/PLL) hydrogels containing curcumin (CUR) and bone morphogenetic protein-2 (BMP-2) as bone tissue regeneration scaffolds.	Lysine	52-65	bone morphogenetic protein 2	Homo sapiens	161-166
27879032-4	2017	We observed that Brahma-related gene 1 (BRG1) and Lysine demethylase 1A (KDM1A), which can alter the methylation status of lysine 4 in histone 3 (H3K4), localize to the nucleus at Day 3-4 of development.	Lysine	123-129	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	17-38
27879032-4	2017	We observed that Brahma-related gene 1 (BRG1) and Lysine demethylase 1A (KDM1A), which can alter the methylation status of lysine 4 in histone 3 (H3K4), localize to the nucleus at Day 3-4 of development.	Lysine	123-129	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	40-44
28101869-7	2017	The fibrinolytic system, with the zymogen plasminogen binding to fibrin together with tissue-type plasminogen activator to promote activation to the active proteolytic enzyme, plasmin, results in digestion of fibrin at specific lysine residues.	Lysine	228-234	plasminogen	Homo sapiens	42-49
27940912-6	2016	Protein lysine methyltransferase SET8 is the sole PKMT to monomethylate histone 4 lysine 20 (H4K20) and its function has been implicated in normal cell cycle progression and cancer metastasis.	Lysine	8-14	lysine methyltransferase 5A	Homo sapiens	33-37
27974220-0	2016	Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.	Lysine	11-17	ataxia telangiectasia mutated	Mus musculus	42-45
27793989-4	2016	In support of this possibility, unbiased molecular docking studies revealed that negatively charged alpha2,3 sialic acid moieties bind tightly to a groove within the PECAM-1 homophilic interface in an orientation that favors the formation of an electrostatic bridge with positively charged Lys-89, mutation of which has been shown previously to disrupt PECAM-1-mediated homophilic binding.	Lysine	290-293	platelet and endothelial cell adhesion molecule 1	Homo sapiens	166-173
27794518-6	2016	Chemical modification studies confirm the requirement for lysine residues in the interaction of fVIII with LRP1.	Lysine	58-64	coagulation factor VIII	Homo sapiens	96-101
27797450-5	2016	SUMMARY: Background Using tissue factor pathway inhibitor (TFPI)-2 Kunitz domain1 (KD1), we obtained a bifunctional antifibrinolytic molecule (KD1L17R -KT ) with C-terminal lysine (kringle domain binding) and P2"-residue arginine (improved specificity towards plasmin).	Lysine	173-179	plasminogen	Homo sapiens	260-267
27528705-1	2016	The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3).	Lysine	106-112	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	29-34
27892467-0	2016	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.	Lysine	36-42	jumonji and AT-rich interaction domain containing 2	Homo sapiens	0-6
27892467-0	2016	Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.	Lysine	36-42	protein regulator of cytokinesis 1	Homo sapiens	95-99
27892467-2	2016	PRC1 and PRC2 modify chromatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation (H3K27me3), respectively.	Lysine	57-63	protein regulator of cytokinesis 1	Homo sapiens	0-4
27892467-2	2016	PRC1 and PRC2 modify chromatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation (H3K27me3), respectively.	Lysine	103-109	protein regulator of cytokinesis 1	Homo sapiens	0-4
27670097-0	2016	Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides.	Lysine	10-16	tyrosine aminotransferase	Homo sapiens	91-94
27670097-1	2016	The two lysine (Lys) residues in the human immunodeficiency virus trans-activator of transcription protein (HIV Tat protein) basic region (residues 47-57) are crucial for two bioactivities: RNA recognition and cellular uptake.	Lysine	8-14	tyrosine aminotransferase	Homo sapiens	112-115
27670097-1	2016	The two lysine (Lys) residues in the human immunodeficiency virus trans-activator of transcription protein (HIV Tat protein) basic region (residues 47-57) are crucial for two bioactivities: RNA recognition and cellular uptake.	Lysine	16-19	tyrosine aminotransferase	Homo sapiens	112-115
27670097-2	2016	Since the post-translational modifications of these two Lys residues affect the biological function of the Tat protein, we investigated the effect of methylation and acetylation of Lys50 and Lys51 in Tat-derived peptides on the two bioactivities.	Lysine	56-59	tyrosine aminotransferase	Homo sapiens	107-110
27670097-3	2016	Tat-derived peptides, in which each lysine was replaced with a methylated- or acetylated-Lys, were synthesized by solid phase peptide synthesis.	Lysine	36-42	tyrosine aminotransferase	Homo sapiens	0-3
27670097-3	2016	Tat-derived peptides, in which each lysine was replaced with a methylated- or acetylated-Lys, were synthesized by solid phase peptide synthesis.	Lysine	89-92	tyrosine aminotransferase	Homo sapiens	0-3
27155006-8	2016	By Sanger sequencing, we detected a homozygous single point mutation c.855T&gt;A in exon 6 of TCN2, corresponding to a asparagine (Asn) to lysine (Lys) substitution in position 267 of the mature protein.	Lysine	139-145	transcobalamin 2	Homo sapiens	94-98
27155006-8	2016	By Sanger sequencing, we detected a homozygous single point mutation c.855T&gt;A in exon 6 of TCN2, corresponding to a asparagine (Asn) to lysine (Lys) substitution in position 267 of the mature protein.	Lysine	147-150	transcobalamin 2	Homo sapiens	94-98
27498087-5	2016	HECW2 physically interacts with AMOTL1 and enhances its stability via lysine 63-linked ubiquitination.	Lysine	70-76	angiomotin like 1	Homo sapiens	32-38
27388964-1	2016	Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on chromatin, acting as co-activators or co-repressors of gene expression.	Lysine	110-116	delta/notch like EGF repeat containing	Homo sapiens	31-34
27591111-12	2016	The specificity of the binding to plasminogen was verified by blocking lysine-binding sites with epsilon-aminocaproic acid.	Lysine	71-77	plasminogen	Homo sapiens	34-45
27940755-0	2016	Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient.	Lysine	0-6	NAD kinase 2, mitochondrial	Homo sapiens	63-68
31898237-2	2020	Neddylation modification is catalyzed by NEDD8-activating enzyme (NAE, E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3) to attach NEDD8, an ubiquitin-like molecule, to a lysine residue of a substrate protein.	Lysine	179-185	NEDD8 ubiquitin like modifier	Homo sapiens	41-46
31898237-2	2020	Neddylation modification is catalyzed by NEDD8-activating enzyme (NAE, E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3) to attach NEDD8, an ubiquitin-like molecule, to a lysine residue of a substrate protein.	Lysine	179-185	NEDD8 ubiquitin like modifier	Homo sapiens	76-81
31898237-2	2020	Neddylation modification is catalyzed by NEDD8-activating enzyme (NAE, E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3) to attach NEDD8, an ubiquitin-like molecule, to a lysine residue of a substrate protein.	Lysine	179-185	NEDD8 ubiquitin like modifier	Homo sapiens	76-81
31898237-2	2020	Neddylation modification is catalyzed by NEDD8-activating enzyme (NAE, E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3) to attach NEDD8, an ubiquitin-like molecule, to a lysine residue of a substrate protein.	Lysine	179-185	NEDD8 ubiquitin like modifier	Homo sapiens	76-81
32668964-9	2020	MLL3 increases the level of monomethylation of Histone 3 Lysine 4 on the enhancer and promoter region of Ras genes, thus causes repression of Ras expressions.	Lysine	57-63	lysine methyltransferase 2C	Homo sapiens	0-4
32955901-10	2020	Phenylalanine, tyrosine, glycine, lysine, and aspartic acid were found to be the headliner amino acids in the interactions between Arbidol and binding domains of spike glycoproteins in the SARS-CoV2 (Tab.	Lysine	34-40	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	162-167
32305562-10	2020	Moreover, our molecular data further demonstrated that Sirt6 deacetylates Smad3 at key lysine residues K333 and K378 and attenuates its transcriptional activity induced by TGFbeta in the hepatic stellate cells.	Lysine	87-93	SMAD family member 3	Mus musculus	74-79
31957467-13	2020	Mechanistically, Ahit directly bound and recruited SUZ12, a core PRC2 (polycomb repressive complex 2) protein, to the promoter of MEF2A, triggering its trimethylation on H3 lysine 27 (H3K27me3) residues and mediating the downregulation of MEF2A, thereby preventing cardiac hypertrophy.	Lysine	173-179	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	51-56
32452005-4	2020	PLG binding was determined by immobilizing human PLG in the plate and incubating with the recombinant protein; competitive binding with a lysine analog demonstrated the interaction of the protein lysine residues with PLG Kringle domains.	Lysine	196-202	plasminogen	Homo sapiens	0-3
32347192-0	2020	Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.	Lysine	26-32	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	17-22
31002112-10	2019	Further analysis confirmed that lysines 381, 382, 386 of p53 are the key sites for the ubiquitination modification of SMYD3 to p53.	Lysine	32-39	SET and MYND domain containing 3	Homo sapiens	118-123
31824148-8	2019	Transferrin receptor 1, TfR1, was detected in lysates prepared from most cancer cell lines studied, contributing to enhanced anticancer potency of the AFt-encapsulated benzothiazoles (5F 203, Phortress, GW 610, GW 608-Lys).	Lysine	218-221	transferrin receptor	Homo sapiens	24-28
31546024-3	2019	Our results indicated that the SUMO1 acceptor site of NRF2 is the conserved lysine residue 110 (K110), and that NRF2 SUMOylation deficiency inhibited tumorigenesis in hepatocellular carcinoma (HCC).	Lysine	76-82	small ubiquitin like modifier 1	Homo sapiens	31-36
31575700-4	2019	Sirtuin 5 (Sirt5), which localizes to both mitochondria and peroxisomes, reverses post-translational lysine acylation on several enzymes involved in fatty acid oxidation.	Lysine	101-107	sirtuin 5	Mus musculus	0-9
31575700-4	2019	Sirtuin 5 (Sirt5), which localizes to both mitochondria and peroxisomes, reverses post-translational lysine acylation on several enzymes involved in fatty acid oxidation.	Lysine	101-107	sirtuin 5	Homo sapiens	11-16
31801253-0	2019	mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth.	Lysine	16-22	CREB regulated transcription coactivator 1	Mus musculus	0-6
31801253-4	2019	In this study, we investigated whether SCs participate directly in Lys-induced skeletal muscle growth and whether the mammalian target of rapamycin complex 1 (mTORC1) pathway was activated both in vivo and in vitro to mediate SC functions in response to Lys supplementation.	Lysine	254-257	CREB regulated transcription coactivator 1	Mus musculus	159-165
31765434-8	2019	TCR cloning and site-directed mutagenesis of the CDR3alpha lysine ablated YVL-BR-tetramer staining and substantially reduced CD69 upregulation on TCR mutant-transduced cells following antigen-specific stimulation.	Lysine	59-65	CD69 molecule	Homo sapiens	125-129
31685935-3	2019	We find that H3K18ac and H3K27ac differentially influence the combined activities of UDG/APE1 on compact chromatin, suggesting that acetylated lysine residues on the H3 tail domain play distinct roles in regulating the initial steps of BER.	Lysine	143-149	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	89-93
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	85-91	lysyl oxidase like 3	Homo sapiens	4-8
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	127-133	lysyl oxidase like 3	Homo sapiens	4-8
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	127-133	lysyl oxidase like 3	Homo sapiens	4-8
31070797-8	2019	Chromatin immunoprecipitation assays identified an FN promoter element in which EZH2-mediated tri-methylation of lysine 27 on histone 3 is diminished by TGF-beta.	Lysine	113-119	transforming growth factor, beta 1	Mus musculus	153-161
31533987-1	2019	SET domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20).	Lysine	78-81	lysine methyltransferase 5A	Homo sapiens	0-31
31533987-1	2019	SET domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20).	Lysine	78-81	lysine methyltransferase 5A	Homo sapiens	33-37
31366618-2	2019	Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.	Lysine	64-70	nicotinamide phosphoribosyltransferase	Homo sapiens	89-127
31366618-2	2019	Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.	Lysine	64-70	nicotinamide phosphoribosyltransferase	Homo sapiens	129-134
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Lysine	196-202	PC4 and SFRS1 interacting protein 1	Homo sapiens	28-65
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Lysine	196-202	PC4 and SFRS1 interacting protein 1	Homo sapiens	67-72
31290578-1	2019	Histone acetyltransferase 1 (Hat1) is responsible for the acetylation of newly synthesized histone H4 on lysines 5 and 12 during the process of chromatin assembly.	Lysine	105-112	histone aminotransferase 1	Mus musculus	0-27
31290578-1	2019	Histone acetyltransferase 1 (Hat1) is responsible for the acetylation of newly synthesized histone H4 on lysines 5 and 12 during the process of chromatin assembly.	Lysine	105-112	histone aminotransferase 1	Mus musculus	29-33
31062674-9	2019	In biceps femoris muscle of lysine-deficient pigs, the activity of FAS and ME enzymes increased, ME1 gene was upregulated (added to FASN gene in the case of Iberian pigs; P < 0.01 to P < 0.001) and PPARA gene was downregulated (P < 0.05).	Lysine	28-34	fatty acid synthase	Sus scrofa	67-70
31062674-9	2019	In biceps femoris muscle of lysine-deficient pigs, the activity of FAS and ME enzymes increased, ME1 gene was upregulated (added to FASN gene in the case of Iberian pigs; P < 0.01 to P < 0.001) and PPARA gene was downregulated (P < 0.05).	Lysine	28-34	fatty acid synthase	Sus scrofa	132-136
31449053-5	2019	Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degradation.	Lysine	85-92	microtubule associated serine/threonine kinase 1	Homo sapiens	44-49
31449053-5	2019	Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degradation.	Lysine	85-92	microtubule associated serine/threonine kinase 1	Homo sapiens	76-81
31376731-0	2019	The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages.	Lysine	111-117	SET domain containing 4	Mus musculus	28-33
31391550-5	2019	Furthermore, the E3 ubiquitin ligase complex component Skp2 through its LRR domain directly interacts with the Prd domain of PAX8 and targets PAX8 by recognizing its lysine 275 for ubiquitination and degradation in hepatoma cells.	Lysine	166-172	S-phase kinase associated protein 2	Homo sapiens	55-59
31391550-5	2019	Furthermore, the E3 ubiquitin ligase complex component Skp2 through its LRR domain directly interacts with the Prd domain of PAX8 and targets PAX8 by recognizing its lysine 275 for ubiquitination and degradation in hepatoma cells.	Lysine	166-172	paired box 8	Homo sapiens	125-129
31391550-5	2019	Furthermore, the E3 ubiquitin ligase complex component Skp2 through its LRR domain directly interacts with the Prd domain of PAX8 and targets PAX8 by recognizing its lysine 275 for ubiquitination and degradation in hepatoma cells.	Lysine	166-172	paired box 8	Homo sapiens	142-146
31366719-7	2019	Moreover, RAD54 accumulates at damaged sites by recognizing histone H3 lysine 4 di-methylation (H3K4me2); the frequency of the interaction between RAD54 and H3K4me2 increased in the ldl1 mutant with DNA double-strand breaks.	Lysine	71-77	DNA repair/recombination protein	Arabidopsis thaliana	10-15
31366719-7	2019	Moreover, RAD54 accumulates at damaged sites by recognizing histone H3 lysine 4 di-methylation (H3K4me2); the frequency of the interaction between RAD54 and H3K4me2 increased in the ldl1 mutant with DNA double-strand breaks.	Lysine	71-77	LSD1-like 1	Arabidopsis thaliana	182-186
31377725-6	2019	PKL interacts with ATX1 to mediate trimethylation of histone H3 on lysine 4 (H3K4me3) at the FT locus, leading to antagonistic effects of PKL and ATX1 on PcG proteins in the regulation of FT expression.	Lysine	67-73	homolog of anti-oxidant 1	Arabidopsis thaliana	19-23
31377725-6	2019	PKL interacts with ATX1 to mediate trimethylation of histone H3 on lysine 4 (H3K4me3) at the FT locus, leading to antagonistic effects of PKL and ATX1 on PcG proteins in the regulation of FT expression.	Lysine	67-73	homolog of anti-oxidant 1	Arabidopsis thaliana	146-150
31482925-0	2019	Post-imparting Bronsted acidity into an amino-functionalized MOF as a bifunctional luminescent turn-ON sensor for the detection of aluminum ions and lysine.	Lysine	149-155	lysine acetyltransferase 8	Homo sapiens	61-64
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	CYLD lysine 63 deubiquitinase	Mus musculus	156-160
31291457-5	2019	At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR.	Lysine	94-100	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	21-25
31291457-5	2019	At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR.	Lysine	94-100	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	86-90
31299085-8	2019	Finally, Ribo-Seq analysis revealed that loss of New1 leads to ribosome queuing upstream of 3"-terminal lysine and arginine codons, including those genes encoding proteins of the cytoplasmic translational machinery.	Lysine	104-110	New1p	Saccharomyces cerevisiae S288C	49-53
27650450-12	2016	Future biochemical analyses will be needed to determine whether destabilization of the RING peroxin complex observed in pex12-1 stems from PEX4-dependent ubiquitination on the pex12-1 ectopic Lys residue.	Lysine	192-195	peroxin4	Arabidopsis thaliana	139-143
27393948-1	2016	Lysine methyltransferase G9a regulates the transcription of multiple genes by primarily catalyzing mono- and di-methylation of histone H3 lysine 9, as well as several non-histone lysine sites.	Lysine	138-144	euchromatic histone lysine N-methyltransferase 2	Mus musculus	25-28
27393948-1	2016	Lysine methyltransferase G9a regulates the transcription of multiple genes by primarily catalyzing mono- and di-methylation of histone H3 lysine 9, as well as several non-histone lysine sites.	Lysine	179-185	euchromatic histone lysine N-methyltransferase 2	Mus musculus	25-28
27472651-4	2016	Here, we examined the importance of a conserved Lys/Arg residue in the ligand-binding site of the second PDZ domain of PSD-95, by employing a semisynthetic approach.	Lysine	48-51	discs large MAGUK scaffold protein 4	Homo sapiens	119-125
27569210-3	2016	SMYD3-mediated dimethylation of H2A.Z.1 at lysine 101 (H2A.Z.1K101me2) increased stability by preventing binding to the removal chaperone ANP32E and facilitating its interaction with histone H3.	Lysine	43-49	SET and MYND domain containing 3	Homo sapiens	0-5
27569210-3	2016	SMYD3-mediated dimethylation of H2A.Z.1 at lysine 101 (H2A.Z.1K101me2) increased stability by preventing binding to the removal chaperone ANP32E and facilitating its interaction with histone H3.	Lysine	43-49	H2A clustered histone 18	Homo sapiens	32-35
27569210-3	2016	SMYD3-mediated dimethylation of H2A.Z.1 at lysine 101 (H2A.Z.1K101me2) increased stability by preventing binding to the removal chaperone ANP32E and facilitating its interaction with histone H3.	Lysine	43-49	acidic nuclear phosphoprotein 32 family member E	Homo sapiens	138-144
31301308-9	2019	The antimigratory, but not the pro-apoptotic, effects of Cat:Lys were found to be mediated by JAK2/STAT3 and Wnt pathway inhibition.	Lysine	61-64	Janus kinase 2	Homo sapiens	94-98
30509560-7	2019	Through a combination of in vitro assays, we demonstrate that Ape1 can bind and process different G4 structures and that this interaction involves specific acetylatable lysine residues (i.e. K27/31/32/35) present in the unstructured N-terminal sequence of the protein.	Lysine	169-175	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	62-66
30509560-7	2019	Through a combination of in vitro assays, we demonstrate that Ape1 can bind and process different G4 structures and that this interaction involves specific acetylatable lysine residues (i.e. K27/31/32/35) present in the unstructured N-terminal sequence of the protein.	Lysine	169-175	keratin 27	Homo sapiens	191-194
30509560-11	2019	Thus, the Ape1 N-terminal sequence is an important relay site for regulating the enzyme"s activity on G4-telomeric sequences, and specific acetylatable lysine residues constitute key regulatory sites of Ape1 enzymatic activity dynamics at telomeres.	Lysine	152-158	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	203-207
30471144-1	2019	Sirt5 is known to functionally regulate mitochondrial proteins by altering posttranslational modifications, including lysine desuccinylation.	Lysine	118-124	sirtuin 5	Mus musculus	0-5
31324717-0	2019	Substrate docking-mediated specific and efficient lysine methylation by the SET domain-containing histone methyltransferase SETD7.	Lysine	50-56	PR/SET domain 9	Homo sapiens	98-123
31407575-0	2019	Histone H3 Lysine 56 Acetylation Enhances AP Endonuclease 1-Mediated Repair of AP Sites in Nucleosome Core Particles.	Lysine	11-17	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	42-59
27626304-5	2016	When target proteins bind the small molecule, they are directly labeled on surface lysines with a biotinylated derivative of the small ubiquitin homologue, NEDD8.	Lysine	83-90	NEDD8 ubiquitin like modifier	Homo sapiens	156-161
27573246-0	2016	Lys-63-linked Ubiquitination of gamma-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.	Lysine	0-3	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	108-119
27573246-6	2016	Here we show that Mind bomb-2 (MIB2)-mediated Lys-63-linked ubiquitination of the GABAB1 subunit at multiple sites is the lysosomal sorting signal for GABAB receptors.	Lysine	46-49	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	18-29
27573246-6	2016	Here we show that Mind bomb-2 (MIB2)-mediated Lys-63-linked ubiquitination of the GABAB1 subunit at multiple sites is the lysosomal sorting signal for GABAB receptors.	Lysine	46-49	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	31-35
30040487-3	2019	In this study, we showed that RYBP inhibits the polyubiquitination-mediated proteasomal degradation of Ring1B independently of its ubiquitin (Ub)-protein isopeptide ligase (E3) ligase activity, leading to its stabilization and increased catalytic activity toward monoubiquitination of histone H2A at lysine 119.	Lysine	300-306	ring finger protein 2	Homo sapiens	103-109
27573246-9	2016	We identified MIB2 as the E3 ligase triggering Lys-63-linked ubiquitination and lysosomal degradation of GABAB receptors.	Lysine	47-50	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	14-18
27573246-12	2016	These findings indicate that Lys-63-linked ubiquitination of GABAB1 at multiple sites by MIB2 controls sorting of GABAB receptors to lysosomes for degradation under physiological and pathological conditions.	Lysine	29-32	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	89-93
30578649-4	2019	RESULTS: We observed a selective down-regulation of fatty acid amide hydrolase (faah) gene expression in the hypothalamus of rats showing the binge-eating behavior with a consistent reduction in histone 3 acetylation at lysine 4 of the gene promoter.	Lysine	220-226	fatty-acid amide hydrolase-like	Rattus norvegicus	80-84
26996668-7	2016	This interaction and ubiquitination is dependent on a critical C terminal lysine residue on C/EBPalpha.	Lysine	74-80	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	92-102
27666593-4	2016	The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414.	Lysine	131-137	ubiquitin specific peptidase 14	Homo sapiens	83-88
31254363-1	2019	Nuclear receptor-binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown.	Lysine	50-56	nuclear receptor binding SET domain protein 3	Homo sapiens	0-37
31254363-1	2019	Nuclear receptor-binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown.	Lysine	50-56	nuclear receptor binding SET domain protein 3	Homo sapiens	39-43
31326165-0	2019	Short communication: Relationship between lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.	Lysine	42-48	mechanistic target of rapamycin kinase	Bos taurus	146-177
31326165-11	2019	Our results indicate that casein synthesis was regulated by Lys/Met ratio via JAK2/ELF5, mTOR, and its downstream RPS6KB1 and EIF4EBP1 signaling.	Lysine	60-63	mechanistic target of rapamycin kinase	Bos taurus	89-93
30531905-5	2019	The N-terminal IDR of DDX3X (IDR1) can undergo LLPS in vitro, and its acetylation at multiple lysine residues impairs the formation of liquid droplets.	Lysine	94-100	DEAD-box helicase 3 X-linked	Homo sapiens	22-27
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	76-82	high mobility group box 1	Mus musculus	244-269
31455361-6	2019	A series of single lysine substitutions in an mCherry tagged USP5 construct followed by expression in tsA-201 cells identified lysine K113 as a key target for USP5 SUMO2/3 modification.	Lysine	19-25	ubiquitin specific peptidase 5	Homo sapiens	61-65
27790061-2	2016	Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), thereby inhibiting the phosphorylation of FAK at tyrosine (Y) 397 residue (pY397-FAK), which is a marker of its activation.	Lysine	116-119	protein tyrosine kinase 2	Homo sapiens	136-157
27790061-2	2016	Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), thereby inhibiting the phosphorylation of FAK at tyrosine (Y) 397 residue (pY397-FAK), which is a marker of its activation.	Lysine	116-119	protein tyrosine kinase 2	Homo sapiens	159-162
27790061-2	2016	Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), thereby inhibiting the phosphorylation of FAK at tyrosine (Y) 397 residue (pY397-FAK), which is a marker of its activation.	Lysine	116-119	protein tyrosine kinase 2	Homo sapiens	207-210
27790061-2	2016	Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), thereby inhibiting the phosphorylation of FAK at tyrosine (Y) 397 residue (pY397-FAK), which is a marker of its activation.	Lysine	116-119	protein tyrosine kinase 2	Homo sapiens	207-210
30359671-5	2019	The histone 3 lysine 9 acetylation (H3K9ac) level in the promoter of renal angiotensin II receptor type 2 (AT2R) and its expression were reduced, whereas the angiotensin II receptor type 1a (AT1aR)/AT2R expression ratio was increased.	Lysine	14-20	angiotensin II receptor, type 2	Rattus norvegicus	75-105
27267320-11	2016	Furthermore, RNA and chromatin immunoprecipitation assays demonstrated that lncRNA-UNMIBC was physically associated with EZH2 and SUZ12, leading to an altered histone H3 lysine 27 methylation status of target genes.	Lysine	170-176	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	130-135
27564657-1	2016	BACKGROUND: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a proenzyme that, once activated, attenuates fibrinolysis by removing C-terminal lysine residues from partially degraded fibrin.	Lysine	147-153	carboxypeptidase B2	Homo sapiens	57-61
31315929-9	2019	Finally, we determined ATG3 residue Lys-243 as an LC3B modification site.	Lysine	36-39	microtubule associated protein 1 light chain 3 beta	Homo sapiens	50-54
30359671-5	2019	The histone 3 lysine 9 acetylation (H3K9ac) level in the promoter of renal angiotensin II receptor type 2 (AT2R) and its expression were reduced, whereas the angiotensin II receptor type 1a (AT1aR)/AT2R expression ratio was increased.	Lysine	14-20	angiotensin II receptor, type 2	Rattus norvegicus	107-111
30566058-10	2018	Chromatin immunoprecipitation assays showed Giver overexpression also increased Pol II (RNA polymerase II) enrichment and decreased repressive histone modification histone H3 trimethylation on lysine 27 at Nox1 and inflammatory gene promoters.	Lysine	193-199	NADPH oxidase 1	Homo sapiens	206-210
31088617-3	2019	In our previous study, we replaced pyridoxal-5-phosphate (PLP) with pyridoxal kinase (PdxY) along with pyridoxal (PL) because it could achieve 80% conversion with 0.4 M of l-lysine in 6 h. However, conversion was sharply decreased in the presence of high concentrations of l-lysine (i.e., 1 M), resulting in less than 40% conversion after several hours.	Lysine	172-180	pyridoxal phosphatase	Homo sapiens	58-61
31088617-3	2019	In our previous study, we replaced pyridoxal-5-phosphate (PLP) with pyridoxal kinase (PdxY) along with pyridoxal (PL) because it could achieve 80% conversion with 0.4 M of l-lysine in 6 h. However, conversion was sharply decreased in the presence of high concentrations of l-lysine (i.e., 1 M), resulting in less than 40% conversion after several hours.	Lysine	273-281	pyridoxal phosphatase	Homo sapiens	58-61
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Lysine	166-169	insulin degrading enzyme	Bos taurus	78-81
30342007-5	2018	Multiple regions of TRIM25 contribute to this functionality, including the C-terminal SPRY domain and a lysine-rich motif in the linker segment connecting the SPRY and coiled-coil domains.	Lysine	104-110	tripartite motif containing 25	Homo sapiens	20-26
27622275-0	2016	The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1.	Lysine	13-19	Sp110 nuclear body protein	Mus musculus	121-156
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Lysine	60-66	Sp110 nuclear body protein	Mus musculus	140-144
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Lysine	60-66	Sp110 nuclear body protein	Mus musculus	290-294
27622275-8	2016	Furthermore, our results show that this arginine/lysine-rich element contributes to the transcriptional regulation and apoptotic activity of Ipr1.	Lysine	49-55	Sp110 nuclear body protein	Mus musculus	141-145
31182557-6	2019	In this complex, HAC1 facilitates the acetylation of histone 3 Lys 27 (H3K27ac) on the sugar-responsive genes.	Lysine	63-66	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	17-21
30522514-1	2018	BACKGROUND: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3).	Lysine	12-18	lysine demethylase 5C	Homo sapiens	52-57
31338059-2	2019	Recently mutations in lysine-specific histone methyltransferase 2B (KMT2B) gene have been reported to be associated with early-onset progressive dystonia.	Lysine	22-28	lysine methyltransferase 2B	Homo sapiens	68-73
27537339-3	2016	Field studies identified scrapie-protective caprine PrP variants, harboring specific single amino acid changes (Met-142, Arg-143, Asp-146, Ser-146, His-154, Gln-211 and Lys-222).	Lysine	169-172	prion protein	Mus musculus	52-55
30522514-1	2018	BACKGROUND: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3).	Lysine	158-164	lysine demethylase 5C	Homo sapiens	52-57
31054182-2	2019	Mutations of SET domain-containing 2 (SETD2), a methyltransferase that catalyses the trimethylation of histone 3 on lysine 36 (H3K36me3), were found in various myeloid malignancies.	Lysine	116-122	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	13-36
30662803-7	2018	Mechanistically, SIRT5 was found to bind to and deacetylate vimentin at lysine 120.	Lysine	72-78	sirtuin 5	Homo sapiens	17-22
31054182-2	2019	Mutations of SET domain-containing 2 (SETD2), a methyltransferase that catalyses the trimethylation of histone 3 on lysine 36 (H3K36me3), were found in various myeloid malignancies.	Lysine	116-122	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	38-43
27337995-4	2016	Here we report that p49/STRAP overexpression caused the deacetylation of histone H4 on lysine 16 (H4K16) and suppressed the expression of PGC-1alpha as well as mitofusin-1 and mitofusin-2 at both the mRNA and protein levels.	Lysine	87-93	serine/threonine kinase receptor associated protein	Homo sapiens	24-29
27256581-3	2016	By applying a penalization method, we identified two genes FGF8 and MDGA2 with significant effects on lysine and cis-4-decenoylcarnitine, respectively, using Delta-AIC and likelihood ratio test statistics.	Lysine	102-108	MAM domain containing glycosylphosphatidylinositol anchor 2	Homo sapiens	68-73
30655368-3	2019	Here we show that both normal and Q287* mutant GFI1B interacted most strongly with the lysine specific demethylase-1 - REST corepressor - histone deacetylase (LSD1-RCOR-HDAC) complex in megakaryoblasts.	Lysine	87-93	growth factor independent 1B transcriptional repressor	Homo sapiens	47-52
30191331-0	2018	Dietary L-lysine supplementation altered the content of pancreatic polypeptide, enzymes involved in glutamine metabolism, and beta-actin in rats.	Lysine	8-16	pancreatic polypeptide	Rattus norvegicus	56-78
31316539-8	2019	Furthermore, SUVH5 represses the transcription of ABA biosynthesis and signal transduction-related genes, as well as a family of DELAY OF GERMINATION (DOG) genes via dimethylation of histone H3 at lysine 9 (H3K9me2) in imbibed seeds.	Lysine	197-203	SU(VAR)3-9 homolog 5	Arabidopsis thaliana	13-18
27550047-1	2016	BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3).	Lysine	273-279	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	216-221
30191331-0	2018	Dietary L-lysine supplementation altered the content of pancreatic polypeptide, enzymes involved in glutamine metabolism, and beta-actin in rats.	Lysine	8-16	actin, beta	Rattus norvegicus	126-136
30191331-6	2018	Supplementation with &gt;= 1% Lys increased serum PP level (P &lt; 0.05), but had no significant effect on pancreatic PP abundance (P &gt; 0.05).	Lysine	30-33	pancreatic polypeptide	Rattus norvegicus	50-52
27382063-3	2016	Here, we report on a detailed molecular investigation of Lys-274 autoacetylation of the human MYST protein Males Absent on the First (hMOF).	Lysine	57-60	lysine acetyltransferase 8	Homo sapiens	134-138
27382063-4	2016	A mutational scan of hMOF Lys-274 reveals that all amino acid substitutions of this residue are able to bind cofactor but are significantly destabilized, both in vitro and in cells, and are catalytically inactive for cognate histone H4 peptide lysine acetylation.	Lysine	26-29	lysine acetyltransferase 8	Homo sapiens	21-25
31054974-3	2019	PHF5A, a component of U2 snRNPs, can be acetylated at lysine 29 in response to multiple cellular stresses, which is dependent on p300.	Lysine	54-60	PHD finger protein 5A	Homo sapiens	0-5
30191331-9	2018	Liver beta-actin significantly increased with both Lys and Arg supplementation and muscle beta-actin significantly decreased (P &lt; 0.05) with &gt;= 1.5% supplemental Lys.	Lysine	51-54	actin, beta	Rattus norvegicus	6-16
31054974-3	2019	PHF5A, a component of U2 snRNPs, can be acetylated at lysine 29 in response to multiple cellular stresses, which is dependent on p300.	Lysine	54-60	E1A binding protein p300	Homo sapiens	129-133
27382063-4	2016	A mutational scan of hMOF Lys-274 reveals that all amino acid substitutions of this residue are able to bind cofactor but are significantly destabilized, both in vitro and in cells, and are catalytically inactive for cognate histone H4 peptide lysine acetylation.	Lysine	244-250	lysine acetyltransferase 8	Homo sapiens	21-25
27382063-7	2016	Together, these studies point to the critical and specific role of hMOF Lys-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys-274 autoacetylation for subsequent cognate substrate acetylation.	Lysine	72-75	lysine acetyltransferase 8	Homo sapiens	67-71
27382063-7	2016	Together, these studies point to the critical and specific role of hMOF Lys-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys-274 autoacetylation for subsequent cognate substrate acetylation.	Lysine	72-75	lysine acetyltransferase 8	Homo sapiens	99-103
30191331-9	2018	Liver beta-actin significantly increased with both Lys and Arg supplementation and muscle beta-actin significantly decreased (P &lt; 0.05) with &gt;= 1.5% supplemental Lys.	Lysine	168-171	actin, beta	Rattus norvegicus	90-100
27382063-7	2016	Together, these studies point to the critical and specific role of hMOF Lys-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys-274 autoacetylation for subsequent cognate substrate acetylation.	Lysine	72-75	lysine acetyltransferase 8	Homo sapiens	99-103
30191331-10	2018	Kidney beta-actin significantly increased with Arg supplementation vs 3% Lys alone (P &lt; 0.05).	Lysine	73-76	actin, beta	Rattus norvegicus	7-17
30191331-11	2018	These results showed that dietary supplementation with &gt;= 1.5% Lys significantly suppressed GlnS expression in the skeletal muscle, which may contribute to the decreased serum Gln levels, and that increased serum PP by Lys may be due to suppressed catabolism rather than increased synthesis of PP.	Lysine	66-69	pancreatic polypeptide	Rattus norvegicus	297-299
30191331-12	2018	Lys-induced PP may play a role in reducing food intake and BWG.	Lysine	0-3	pancreatic polypeptide	Rattus norvegicus	12-14
31171769-6	2019	In addition, we revealed that miR-708 was transcriptionally repressed by EZH2 (enhancer of zeste homolog 2)-induced histone H3 lysine 27 trimethylation and promoter methylation.	Lysine	127-133	microRNA 708	Homo sapiens	30-37
30318657-6	2018	Insulin concentration was greater with Thr, glucagon levels were increased with Lys, Thr, Val, and Glu, whereas IGF-1 levels were enhanced with Gln, Lys, and Thr supply.	Lysine	149-152	insulin-like growth factor I	Ovis aries	112-117
27468126-1	2016	EZH2 or EZH1 (enhancer of zeste homologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	156-162	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	8-12
30849519-7	2019	A lysine residue lys151 was identified as the ubiquitin acceptor site within the TTF1.	Lysine	2-8	transcription termination factor 1	Homo sapiens	81-85
30504241-8	2018	This incomplete block of KCNQ2/3 channels by HN38 appears to be partially due to the conformation of the KCNQ2/3 outer vestibule and in particular the outer turret lysine 259 of KCNQ3 channels.	Lysine	164-170	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	178-183
30578720-0	2019	Identification of a novel hemoglobin variant Hb Jilin [alpha139(HC1)Lys&gt;Gln; HBA2:C.418 A&gt;C] in a Chinese family.	Lysine	68-71	hemoglobin subunit alpha 2	Homo sapiens	80-84
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	ring finger protein 122	Mus musculus	28-34
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	ring finger protein 122	Mus musculus	176-182
30498193-6	2018	MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	146-152	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	14-18
27550794-6	2016	We thus explain the previously described unidirectional nature of lysine transport in S. cerevisiae by the extraordinary kinetics of Lyp1 and provide a mechanism and rationale for previous observations.	Lysine	66-72	lysine permease	Saccharomyces cerevisiae S288C	133-137
31066241-2	2019	Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs671 with BC risk and its interaction with alcohol intake have not been fully elucidated.	Lysine	71-74	aldehyde dehydrogenase 2 family member	Homo sapiens	13-37
31066241-2	2019	Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs671 with BC risk and its interaction with alcohol intake have not been fully elucidated.	Lysine	71-74	aldehyde dehydrogenase 2 family member	Homo sapiens	39-44
30305391-3	2018	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2, represses target genes through trimethylation of histone H3 at Lys-27 (H3K27me3), and interacts (in)directly with both protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 (NIPP1).	Lysine	187-190	protein phosphatase 1 catalytic subunit gamma	Mus musculus	243-264
30942468-6	2019	In addition, deletion mutants without RING domain or C-terminus of TRAIP diminished the ability to induce H2B monoubiquitination at lysine 120.	Lysine	132-138	TRAF interacting protein	Homo sapiens	67-72
27411844-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	0-5
27411844-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	6-10
27411844-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	11-18
27411844-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	19-24
32884994-5	2020	In cells transiently transfected with ubiquitin (UB) constructs contained different lysine residues (Ks), Vps34 ubiquitination could occur regardless of the presence of any Ks in UB.	Lysine	84-90	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	106-111
30305391-3	2018	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2, represses target genes through trimethylation of histone H3 at Lys-27 (H3K27me3), and interacts (in)directly with both protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 (NIPP1).	Lysine	187-190	protein phosphatase 1 catalytic subunit gamma	Mus musculus	266-269
27509863-2	2016	Proliferating cell nuclear antigen (PCNA) is modified by Ub or poly-Ub at lysine (Lys)164 after DNA damage to recruit repair factors.	Lysine	74-80	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	0-34
27509863-2	2016	Proliferating cell nuclear antigen (PCNA) is modified by Ub or poly-Ub at lysine (Lys)164 after DNA damage to recruit repair factors.	Lysine	74-80	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	36-40
27509863-2	2016	Proliferating cell nuclear antigen (PCNA) is modified by Ub or poly-Ub at lysine (Lys)164 after DNA damage to recruit repair factors.	Lysine	82-85	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	0-34
27509863-2	2016	Proliferating cell nuclear antigen (PCNA) is modified by Ub or poly-Ub at lysine (Lys)164 after DNA damage to recruit repair factors.	Lysine	82-85	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	36-40
30464261-7	2018	The identified binding motif overlaps with the recognition sites of many other collagen-binding partners (e.g. PEDF, Heparin) and also spans the lysine residues, which form collagen cross-links.	Lysine	145-151	serpin family F member 1	Homo sapiens	111-115
27312528-4	2016	Mechanistic investigations revealed that FAT10 competed with ubiquitin (Ub) for binding to the same lysines on eEF1A1 to form either FAT10-eEF1A1 or Ub-eEF1A1 complexes, respectively, such that FAT10 overexpression decreased Ub-eEF1A1 levels and increased FAT10-eEF1A1 levels.	Lysine	100-107	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	111-117
30894089-10	2019	Mechanistically, SIRT6 induced the expression of GATA5 (GATA-binding protein 5), a novel regulator of blood pressure, through inhibiting Nkx3.2 (NK3 homeobox 2) transcription by deacetylating histone H3K9 (histone H3 lysine 9), thereby regulating GATA5-mediated signaling pathways to prevent endothelial injury.	Lysine	217-223	GATA binding protein 5	Mus musculus	49-54
30894089-10	2019	Mechanistically, SIRT6 induced the expression of GATA5 (GATA-binding protein 5), a novel regulator of blood pressure, through inhibiting Nkx3.2 (NK3 homeobox 2) transcription by deacetylating histone H3K9 (histone H3 lysine 9), thereby regulating GATA5-mediated signaling pathways to prevent endothelial injury.	Lysine	217-223	GATA binding protein 5	Mus musculus	56-78
30842320-0	2019	A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein.	Lysine	2-8	replication-associated protein	Tomato yellow leaf curl virus	43-46
30515162-2	2018	SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine to regulate metabolic and oxidative stress response pathways.	Lysine	131-137	sirtuin 5	Mus musculus	0-5
30842320-5	2019	Here, we show that one conserved lysine in the N-terminal part of Rep is pivotal for nuclear localization of the Rep protein from Tomato yellow leaf curl virus (TYLCV), with two other lysines also contributing to its nuclear import.	Lysine	33-39	replication-associated protein	Tomato yellow leaf curl virus	66-69
30842320-5	2019	Here, we show that one conserved lysine in the N-terminal part of Rep is pivotal for nuclear localization of the Rep protein from Tomato yellow leaf curl virus (TYLCV), with two other lysines also contributing to its nuclear import.	Lysine	33-39	replication-associated protein	Tomato yellow leaf curl virus	113-116
30842320-7	2019	We here show that mutating these lysines leads to nuclear exclusion of TYLCV Rep without compromising its interaction with SCE1.	Lysine	33-40	replication-associated protein	Tomato yellow leaf curl virus	77-80
30842320-8	2019	Moreover, the ability of TYLCV Rep to promote viral DNA replication also depends on this highly conserved lysine independently of its role in nuclear import of Rep.	Lysine	106-112	replication-associated protein	Tomato yellow leaf curl virus	31-34
30842320-9	2019	Our data thus reveal that this lysine potentially has a broad role in geminivirus replication, but its role in nuclear import and SCE1 binding differs depending on the Rep protein examined.IMPORTANCE Nuclear activity of the replication initiator protein (Rep) of geminiviruses is essential for viral replication.	Lysine	31-37	replication-associated protein	Tomato yellow leaf curl virus	168-171
30842320-9	2019	Our data thus reveal that this lysine potentially has a broad role in geminivirus replication, but its role in nuclear import and SCE1 binding differs depending on the Rep protein examined.IMPORTANCE Nuclear activity of the replication initiator protein (Rep) of geminiviruses is essential for viral replication.	Lysine	31-37	replication-associated protein	Tomato yellow leaf curl virus	255-258
30842320-10	2019	We now define that one highly conserved lysine is important for nuclear import of Rep from three different begomoviruses.	Lysine	40-46	replication-associated protein	Tomato yellow leaf curl virus	82-85
27406796-4	2016	The molecular docking studies revealed multiple hydrogen bond interactions by the synthesized compounds with various amino acid residues, viz, ASP-133, LYS-183, PRO-136, VAL-135, TYR-134, or LYS-60 at the GSK-3beta receptor site.	Lysine	191-194	glycogen synthase kinase 3 beta	Homo sapiens	205-214
30451821-5	2018	RORgammat is SUMO3-modified by E3 ligase PIAS4 at lysine 31 (K31), and the mutation of K31 to arginine in mice prevents RORgammat sumoylation, leading to impaired TH17 differentiation, resistance to TH17-mediated EAE, accumulation of thymic ISPs, and a lack of Peyer"s patches.	Lysine	50-56	small ubiquitin-like modifier 3	Mus musculus	13-18
27487210-7	2016	Our data reveal that CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases, suggesting that the mTORC1 pathway exploited an ancient, amino-acid-dependent allosteric mechanism to acquire arginine sensitivity.	Lysine	77-83	CREB regulated transcription coactivator 1	Mus musculus	164-170
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	small ubiquitin like modifier 1	Homo sapiens	64-69
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	36-39	small ubiquitin-related modifier 2	Mandrillus leucophaeus	71-76
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	92-95	small ubiquitin-related modifier 2	Mandrillus leucophaeus	71-76
30651372-7	2019	rs34988193 is a germline variant found in the tumor suppressor gene ANKDD1a that causes an amino acid change from lysine to glutamate.	Lysine	114-120	ankyrin repeat and death domain containing 1A	Homo sapiens	68-75
30446507-3	2018	This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively).	Lysine	152-158	N-acetyltransferase 8 (GCN5-related)	Mus musculus	189-195
31024026-3	2019	Polycomb repressive complex 2 (PRC2), which contains core subunits (EZH2, EED, and SUZ12), regulates gene activity by trimethylation of histone 3 lysine 27.	Lysine	146-152	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	83-88
30446507-3	2018	This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively).	Lysine	152-158	N-acetyltransferase 8B, pseudogene	Mus musculus	211-216
27250692-1	2016	Hb E-Saskatoon [beta22(B4)Glu Lys, HBB: c.67G &gt; A] is a rare, nonpathological beta-globin variant that was first described in a Canadian woman of Scottish and Dutch ancestry and has since then been detected in several populations.	Lysine	30-33	hemoglobin subunit epsilon 1	Homo sapiens	0-4
30446507-3	2018	This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively).	Lysine	152-158	N-acetyltransferase 8 (GCN5-related)	Mus musculus	211-215
30389664-7	2018	HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis.	Lysine	60-66	fibroblast growth factor 21	Mus musculus	229-234
27127218-7	2016	RESULTS: Conjugation of DOTA and NODAGA chelators at positions Lys(27) and Lys(40) of Ex(9-39)NH2 resulted in a distinct loss of affinity toward GLP-1 receptor in vitro.	Lysine	63-66	glucagon like peptide 1 receptor	Homo sapiens	145-159
27127218-7	2016	RESULTS: Conjugation of DOTA and NODAGA chelators at positions Lys(27) and Lys(40) of Ex(9-39)NH2 resulted in a distinct loss of affinity toward GLP-1 receptor in vitro.	Lysine	75-78	glucagon like peptide 1 receptor	Homo sapiens	145-159
27146988-9	2016	Kv1.3/Nedd4-2 were reciprocally coimmunoprecipated, whereby mutation of the COOH-terminal, SH3-recognition (493-498), or ubiquitination sites on Kv1.3 (lysines 467, 476, 498) retained coimmunoprecipitation, while the latter prevented the reduction in channel density.	Lysine	152-159	potassium voltage-gated channel subfamily A member 3	Homo sapiens	0-5
27146988-9	2016	Kv1.3/Nedd4-2 were reciprocally coimmunoprecipated, whereby mutation of the COOH-terminal, SH3-recognition (493-498), or ubiquitination sites on Kv1.3 (lysines 467, 476, 498) retained coimmunoprecipitation, while the latter prevented the reduction in channel density.	Lysine	152-159	potassium voltage-gated channel subfamily A member 3	Homo sapiens	145-150
30833073-3	2019	We previously showed that generation of nuclear 4ICD by neuregulin-1 (NRG-1) stimulation enhances the levels of trimethylation of histone H3 at lysine 9 (H3K9me3).	Lysine	144-150	neuregulin 1	Homo sapiens	56-70
30833073-3	2019	We previously showed that generation of nuclear 4ICD by neuregulin-1 (NRG-1) stimulation enhances the levels of trimethylation of histone H3 at lysine 9 (H3K9me3).	Lysine	144-150	neuregulin 1	Homo sapiens	70-75
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	lysine methyltransferase 2B	Homo sapiens	104-108
27304234-0	2016	Correction to Protein Lysine Acetylation by p300/CBP.	Lysine	22-28	E1A binding protein p300	Homo sapiens	44-48
30420689-7	2018	Restoring Ikaros function by Casein Kinase II inhibition also promotes ARID5B expression through recruitment of trimethylation of lysine 4 on histone H3 (H3K4me3) at its promoter region.	Lysine	130-136	IKAROS family zinc finger 1	Homo sapiens	10-16
27332697-2	2016	p300/CBP is a multidomain protein and possesses a highly conserved bromodomain that has been shown to bind acetylated Lys residues in both proteins and various small molecules, including I-CBP112 and CBP30.	Lysine	118-121	E1A binding protein p300	Homo sapiens	0-4
30772743-6	2019	Among them, single nucleotide polymorphism (SNP) rs4639425 in KMT2C gene, which regulates histone H3 lysine 4 (H3K4) methylation involved in chromatin remodeling, was associated with widespread alterations of white matter integrity including the cingulum, uncinate fasciculus, cortico-spinal tract, and superior longitudinal fasciculus.	Lysine	101-107	lysine methyltransferase 2C	Homo sapiens	62-67
31024250-3	2019	EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and trimethylation of lysine 27 of histone 3 (H3K27Me3), the chromatin mark associated with gene silencing.	Lysine	127-133	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	14-19
30318121-4	2018	Our findings demonstrate that Bcl-w enhances the activity of senescence-associated beta-galactosidase (SA-beta-gal) and promotes histone H3 tri-methylation at lysine 9 (H3K9me3) and expressions of p53, Notch2, p21, and p16-hallmarks of the senescent phenotype-in human U251 glioblastoma and H460 lung carcinoma cells.	Lysine	159-165	BCL2 like 2	Homo sapiens	30-35
30799082-10	2019	We predicted through UCSC database and validated by ChIP assay that EZH2, a crucial regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), bound to CPEB3 promoter.	Lysine	129-135	cytoplasmic polyadenylation element binding protein 3	Homo sapiens	160-165
27226597-4	2016	We used the genetic code expansion concept to produce natively folded, site-specific, and lysine-acetylated Sirt1-3 substrate proteins, namely Ras-related nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation reaction.	Lysine	90-96	heat shock protein family E (Hsp10) member 1	Homo sapiens	218-223
30228180-7	2018	Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5).	Lysine	104-107	prostaglandin D2 receptor	Homo sapiens	33-36
26861461-6	2016	SIRT6 was recruited to the promoter of Bax, where it deacetylated histone 3 lysine 9 and suppressed its promoter activity.	Lysine	76-82	sirtuin 6	Homo sapiens	0-5
30720068-5	2019	Furthermore, bioinformatic analysis followed by chromatin immunoprecipitation verified an enriched histone H3 on lysine 27 (H3K27) acetylation (H3K27ac) at the promoter region of the PLAC2 gene.	Lysine	113-119	TINCR ubiquitin domain containing	Homo sapiens	183-188
30865465-2	2019	Glatiramer acetate was originally developed to emulate human myelin basic protein, which contains four different residues [alanine (A), glutamic acid (E), tyrosine (T), and lysine (K)].	Lysine	173-179	myelin basic protein	Homo sapiens	61-81
30110572-17	2018	Taken together, our results suggest that superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and BP in rats.	Lysine	76-82	renin	Rattus norvegicus	106-111
30922329-1	2019	BACKGROUND: SETD2, the single mediator of trimethylation of histone 3 at position lysine 36, has been reported associated with initiation progression and chemotherapy resistance in acute myeloid leukemia (AML).	Lysine	82-88	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	12-17
27259240-4	2016	Mixed-lineage leukemia (MLL), a histone methyltransferase, was upregulated, leading to increased trimethylation of histone H3 lysine 4, while G9a was downregulated, leading to decreased dimethylation of histone H3 lysine 9. siRNA-mediated MLL knockdown decreased levels of Nrf2 and HO-1 to a greater extent than did silencing HAT1.	Lysine	126-132	PR/SET domain 9	Homo sapiens	32-57
27259240-4	2016	Mixed-lineage leukemia (MLL), a histone methyltransferase, was upregulated, leading to increased trimethylation of histone H3 lysine 4, while G9a was downregulated, leading to decreased dimethylation of histone H3 lysine 9. siRNA-mediated MLL knockdown decreased levels of Nrf2 and HO-1 to a greater extent than did silencing HAT1.	Lysine	214-220	PR/SET domain 9	Homo sapiens	32-57
30278358-5	2018	Post-translationally modified YB-1 (lysine 301/304 acetylation) is detected at high levels in the nucleus of adherent and invading CD14+CD68+ monocytes from umbilical cord and atherosclerosis-prone vessels.	Lysine	36-42	CD14 molecule	Homo sapiens	131-135
27516964-2	2016	Hypusine is formed by two sequential enzymatic steps at a specific lysine residue in the precursor protein EIF-5A.	Lysine	67-73	eukaryotic translation initiation factor 5A	Mus musculus	107-113
27253878-2	2016	In Arabidopsis thaliana, mutation of the ATXR5 and ATXR6 histone methyltransferases causes reduction in histone H3 lysine 27 monomethylation, transcriptional upregulation of transposons, and a genome instability defect in which there is an accumulation of excess DNA corresponding to pericentromeric heterochromatin.	Lysine	115-121	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	51-56
30886743-6	2019	Strikingly, we found that TRIAD3 synthesises specifically lysine-63 (K63)-linked poly-ubiquitin chains in vitro, a chain type that usually plays a role in mediating signalling events rather than triggering proteasomal degradation.	Lysine	58-64	ring finger protein 216	Homo sapiens	26-32
30842412-4	2019	Structure and function analysis suggests that lysine 267 of Ufbp1, the main lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is required for immunoglobulin production and stimulation of ER expansion in IRE1alpha-deficient plasmablasts.	Lysine	46-52	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	252-261
30100102-5	2018	As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63-linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity.	Lysine	134-140	OTU deubiquitinase 1	Homo sapiens	21-26
30770441-5	2019	In the resting state, Ca2+ binding at the luminal surface of TRIC-A, on its threefold axis, stabilizes lysine blockage of the pores.	Lysine	103-109	transmembrane protein 38A	Homo sapiens	61-67
27221823-3	2016	Carboxyl terminal lysine residues play a pivotal role in enhancing cell surface plasminogen activation to plasmin.	Lysine	18-24	plasminogen	Homo sapiens	80-87
30405805-7	2018	The JMJD1A protein, but not a catalytically inactive mutant, activated the ATRX gene promoter and JMJD1A also affected levels of dimethylation on lysine 9 of histone H3.	Lysine	146-152	ATRX chromatin remodeler	Homo sapiens	75-79
27462461-6	2016	Moreover, the acetylation of Cdc25A at lysine 150, which was acetylated by p300/CBP and deacetylated by HDAC3, prevented the ubiquitin-mediated degradation of Cdc25A by the proteasome.	Lysine	39-45	E1A binding protein p300	Homo sapiens	75-79
27462461-6	2016	Moreover, the acetylation of Cdc25A at lysine 150, which was acetylated by p300/CBP and deacetylated by HDAC3, prevented the ubiquitin-mediated degradation of Cdc25A by the proteasome.	Lysine	39-45	histone deacetylase 3	Homo sapiens	104-109
30833558-4	2019	The hypoxia-activated E3 ligase SIAH2 spatially downregulates nuclear-encoded mitochondrial gene expression including pyruvate dehydrogenase beta via degrading NRF1 (Nuclear Respiratory Factor 1) through ubiquitination on lysine 230, resulting in enhanced Warburg effect, metabolic reprogramming and pro-tumor immune response.	Lysine	222-228	siah E3 ubiquitin protein ligase 2	Homo sapiens	32-37
30833558-4	2019	The hypoxia-activated E3 ligase SIAH2 spatially downregulates nuclear-encoded mitochondrial gene expression including pyruvate dehydrogenase beta via degrading NRF1 (Nuclear Respiratory Factor 1) through ubiquitination on lysine 230, resulting in enhanced Warburg effect, metabolic reprogramming and pro-tumor immune response.	Lysine	222-228	nuclear respiratory factor 1	Homo sapiens	160-164
30833558-4	2019	The hypoxia-activated E3 ligase SIAH2 spatially downregulates nuclear-encoded mitochondrial gene expression including pyruvate dehydrogenase beta via degrading NRF1 (Nuclear Respiratory Factor 1) through ubiquitination on lysine 230, resulting in enhanced Warburg effect, metabolic reprogramming and pro-tumor immune response.	Lysine	222-228	nuclear respiratory factor 1	Homo sapiens	166-194
27181629-10	2016	These data suggest that rs671, a common functional SNP of ALDH2, is a genuine gout-associated SNP in the MYL2-CUX2 locus and that "A" allele (Lys) of rs671 plays a protective role in the development of gout.	Lysine	142-145	aldehyde dehydrogenase 2 family member	Homo sapiens	58-63
30365547-1	2018	In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleosomes.	Lysine	205-211	PR/SET domain 9	Homo sapiens	129-134
27183223-9	2016	Feature contribution analysis indicated that HSE features, which were firstly introduced for lysine acetylation prediction, significantly improved the predictive performance.	Lysine	93-99	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	45-48
27154193-13	2016	Additionally chromatin immunoprecipitation assay demonstrated that, after silencing SBF2-AS1, the enrichment of SUZ12 and trimethylation of histone 3 lysine 27 decreased at the promoter region of P21.	Lysine	150-156	SBF2 antisense RNA 1	Homo sapiens	84-92
27066749-5	2016	A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3.	Lysine	122-128	SET and MYND domain containing 3	Homo sapiens	139-144
30445013-6	2019	We studied mice with liver parenchymal cell (LPC)-specific disruption of the cylindromatosis (CYLD) lysine 63 deubiquitinase gene (Cyld), with or without disruption of Relb (CyldDeltaLPC mice and Cyld/RelbDeltaLPC mice) and compared them with C57BL/6 mice (controls).	Lysine	100-106	CYLD lysine 63 deubiquitinase	Mus musculus	94-98
30699288-7	2019	Because the PLP-binding lysine in ODC, LODC, DAPDC, and DOKDC is located on the re-face of the PLP, we propose that this is the acid group responsible for protonation of the product, thus resulting in the observed retention of configuration for decarboxylation of l-amino acids and inversion for decarboxylation of d-amino acids.	Lysine	24-30	ornithine decarboxylase 1	Homo sapiens	34-37
30528377-0	2019	Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control.	Lysine	36-42	solute carrier family 2 member 4	Homo sapiens	61-67
30528377-4	2019	In both T1D-like and T2D-like animals, tri-methylation at lysine 9 of histone 3 (H3K9me3) increased in the Slc2a4 enhancer segment, whereas MEF2A/D binding into this segment was reduced; all effects were reversed by respective treatments.	Lysine	58-64	solute carrier family 2 member 4	Homo sapiens	107-113
30365547-1	2018	In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleosomes.	Lysine	218-224	PR/SET domain 9	Homo sapiens	129-134
30386240-5	2018	We observed an a decrease of HP1gamma, a methylated lysine 9 of histone H3-specific reader protein, in AZA-sensitive cells after treatment, whereas AZA treatment did not affect HP1 family proteins in AZA-resistant cells.	Lysine	52-58	chromobox 3	Homo sapiens	29-37
30718488-5	2019	In particular, the H4 N-terminal tail interacts with glutamine-76 and aspartate-77 of canonical H3.1 while these interactions are cancelled in the presence of the CENP-A-specific residues valine-76 and lysine-77.	Lysine	202-208	centromere protein A	Homo sapiens	163-169
27136092-1	2016	Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes.	Lysine	174-180	polycomb group ring finger 1	Mus musculus	37-42
27136092-1	2016	Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes.	Lysine	174-180	polycomb group ring finger 6	Mus musculus	43-48
27231670-5	2016	Recently, it was shown that APE1/Ref-1 is secreted in response to hyperacetylation at specific lysine residues.	Lysine	95-101	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	28-32
27231670-5	2016	Recently, it was shown that APE1/Ref-1 is secreted in response to hyperacetylation at specific lysine residues.	Lysine	95-101	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	33-38
29881949-0	2019	Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) beta-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination.	Lysine	103-106	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	148-159
29881949-0	2019	Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) beta-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination.	Lysine	103-106	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	161-165
30304769-7	2018	Chromatin immunoprecipitation coupled with high-throughput sequencing for histone H3 lysine 27 (H3K27) acetylation revealed numerous putative super-enhancers near key transcription factors, including MYC, MYB, and LEF1.	Lysine	85-91	lymphoid enhancer binding factor 1	Homo sapiens	214-218
29881949-4	2019	Lys-63-linked ubiquitination mediated by the E3 ligase Mind bomb-2 (MIB2) is the signal that sorts GABAB receptors to lysosomes.	Lysine	0-3	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	55-66
27525255-7	2016	By using in silico, biochemical, and cell biological approaches, we now demonstrate that human DISC1 is SUMOylated at one specific lysine 643 (K643).	Lysine	131-137	DISC1 scaffold protein	Homo sapiens	95-100
29881949-4	2019	Lys-63-linked ubiquitination mediated by the E3 ligase Mind bomb-2 (MIB2) is the signal that sorts GABAB receptors to lysosomes.	Lysine	0-3	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	68-72
30063986-3	2018	Previously we have reported that H. pylori promotes gastric cancer invasiveness by stabilizing the E3 ubiquitin ligase Siah2 which is mediated by Siah2 acetylation at Lys 139 (K139) residue.	Lysine	167-170	siah E3 ubiquitin protein ligase 2	Homo sapiens	119-124
29881949-6	2019	Here, we show that Ca2+/calmodulin-dependent protein kinase II (CaMKII) promotes MIB2-mediated Lys-63-linked ubiquitination of GABAB receptors.	Lysine	95-98	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	81-85
29881949-8	2019	This effect was conveyed by Lys-63-linked ubiquitination of GABAB1 at multiple sites mediated by the E3 ligase MIB2.	Lysine	28-31	MIB E3 ubiquitin protein ligase 2	Rattus norvegicus	111-115
26434593-1	2016	MOF (males absent on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic acetylation of histone H4 lysine 16.	Lysine	145-151	lysine acetyltransferase 8	Homo sapiens	0-3
30063986-3	2018	Previously we have reported that H. pylori promotes gastric cancer invasiveness by stabilizing the E3 ubiquitin ligase Siah2 which is mediated by Siah2 acetylation at Lys 139 (K139) residue.	Lysine	167-170	siah E3 ubiquitin protein ligase 2	Homo sapiens	146-151
27111853-4	2016	The 3X malignant brain tumor domain (3XMBT) repeats of the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) have been utilized in the past as an affinity reagent for the identification of mono- and di-methylated lysine residues on individual proteins and on a proteomic scale.	Lysine	219-225	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	59-104
30143782-7	2019	Our epigenetic analysis of the Rac1 gene promoter suggested that persistent suppression of Rac1 expression is mediated by enhanced histone H3 lysine 9 dimethylation (H3K9me2), a repressive chromatin state, via G9a recruitment.	Lysine	142-148	Rac family small GTPase 1	Mus musculus	31-35
30143782-7	2019	Our epigenetic analysis of the Rac1 gene promoter suggested that persistent suppression of Rac1 expression is mediated by enhanced histone H3 lysine 9 dimethylation (H3K9me2), a repressive chromatin state, via G9a recruitment.	Lysine	142-148	Rac family small GTPase 1	Mus musculus	91-95
27111853-4	2016	The 3X malignant brain tumor domain (3XMBT) repeats of the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) have been utilized in the past as an affinity reagent for the identification of mono- and di-methylated lysine residues on individual proteins and on a proteomic scale.	Lysine	219-225	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	106-113
30323286-3	2018	Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly conserved and intrinsically disordered autoinhibitory lysine-rich loop, resulting in p300 activation.	Lysine	217-223	interferon regulatory factor 3	Homo sapiens	39-43
30683849-1	2019	SETD3 is a member of the protein lysine methyltransferase (PKMT) family, which catalyzes the addition of methyl group to lysine residues.	Lysine	33-39	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	0-5
30323286-3	2018	Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly conserved and intrinsically disordered autoinhibitory lysine-rich loop, resulting in p300 activation.	Lysine	217-223	E1A binding protein p300	Homo sapiens	146-150
25532033-7	2016	Monomethylation of lysine 43 (K43), a proposed neutrophil-specific PTM, was strongly associated with high HMGB1 levels, implying that neutrophils are a source of released HMGB1.	Lysine	19-25	high mobility group box 1	Homo sapiens	106-111
30323286-3	2018	Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly conserved and intrinsically disordered autoinhibitory lysine-rich loop, resulting in p300 activation.	Lysine	217-223	E1A binding protein p300	Homo sapiens	248-252
25532033-7	2016	Monomethylation of lysine 43 (K43), a proposed neutrophil-specific PTM, was strongly associated with high HMGB1 levels, implying that neutrophils are a source of released HMGB1.	Lysine	19-25	high mobility group box 1	Homo sapiens	171-176
30237125-2	2018	Structurally, the catalytic subunit NAA10 was believed to have no activity toward an internal lysine residue because the gate of its catalytic pocket is too narrow.	Lysine	94-100	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	36-41
26981776-6	2016	We found that APE1 is proteolytically cleaved by an unknown serine protease at its N-terminus following residue lysine (Lys) Lys6 and/or Lys7 and after Lys27 and Lys31 or Lys32.	Lysine	112-118	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	14-18
30881620-3	2019	Our previous SAR studies of compounds, showing affinity for NRP-1, led us to develop branched peptides with general formula Lys(hArg)-AA2-AA3-Arg.	Lysine	124-127	neuropilin 1	Homo sapiens	60-65
30612740-2	2019	Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo.	Lysine	119-125	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	79-84
30612740-2	2019	Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo.	Lysine	119-125	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	86-117
26981776-6	2016	We found that APE1 is proteolytically cleaved by an unknown serine protease at its N-terminus following residue lysine (Lys) Lys6 and/or Lys7 and after Lys27 and Lys31 or Lys32.	Lysine	120-123	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	14-18
26981776-7	2016	Acetylation of these Lys residues in APE1 prevents this proteolysis.	Lysine	21-24	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	37-41
30237125-3	2018	However, several studies have demonstrated that the monomeric NAA10 can acetylate the internal lysine residues of several substrates including hypoxia-inducible factor 1alpha (HIF-1alpha).	Lysine	95-101	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	62-67
27058665-2	2016	Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, including almost all super-enhancers.	Lysine	107-113	lysine demethylase 5C	Homo sapiens	158-163
30237125-4	2018	How NAA10 acetylates lysine residues has been an unsolved question.	Lysine	21-27	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	4-9
27058938-6	2016	Mechanistically, SIRT6 inhibits the transcription of Wnt target genes by interacting with transcription factor LEF1 and deacetylating histone 3 at lysine 56.	Lysine	147-153	sirtuin 6	Homo sapiens	17-22
30324105-3	2018	BS69 (ZMYND11), a multidomain-containing (i.e., PHD, BROMO, PWWP, and MYND) protein, has been shown to selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3), modulates RNA Polymerase II elongation, and functions as RNA splicing regulator.	Lysine	147-153	zinc finger, MYND-type containing 11	Danio rerio	0-4
30655546-3	2019	Here, we show that high maternal glucose induced MARCKS acetylation at lysine 165 by the acetyltransferase Tip60, which is a prerequisite for its phosphorylation, whereas Sirtuin 2 (SIRT2) deacetylated MARCKS.	Lysine	71-77	myristoylated alanine rich protein kinase C substrate	Homo sapiens	49-55
26174182-12	2016	On day 110 of gestation, gilts fed the 0.70% SID Lys diet tended to have the highest serum prolactin (p = 0.085) and serum insulin (p = 0.074) levels.	Lysine	49-52	insulin	Sus scrofa	123-130
30324105-3	2018	BS69 (ZMYND11), a multidomain-containing (i.e., PHD, BROMO, PWWP, and MYND) protein, has been shown to selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3), modulates RNA Polymerase II elongation, and functions as RNA splicing regulator.	Lysine	147-153	zinc finger, MYND-type containing 11	Danio rerio	6-13
30389668-3	2019	Here, we investigated how methylation of arginine 37 (R37Me) and acetylation of lysine 49 (K49Ac) on the CENP-A homolog Cse4 from Saccharomyces cerevisiae regulate molecular interactions at the inner kinetochore.	Lysine	80-86	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	120-124
30257200-7	2018	In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents tissue regeneration.	Lysine	64-70	chemokine (C-X-C motif) ligand 12	Mus musculus	110-114
30595158-9	2019	The molecular characterization identified the new transversion mutation HBA1: c.49 A&gt;T, which resulted in an amino acid change of Lys &gt; Stop at codon 16 of exon 1 in the state heterozygous [alpha116 (A14) Lys&gt;Stop; HBA1: c.49A&gt;T].	Lysine	133-136	hemoglobin subunit alpha 1	Homo sapiens	72-76
30595158-9	2019	The molecular characterization identified the new transversion mutation HBA1: c.49 A&gt;T, which resulted in an amino acid change of Lys &gt; Stop at codon 16 of exon 1 in the state heterozygous [alpha116 (A14) Lys&gt;Stop; HBA1: c.49A&gt;T].	Lysine	133-136	hemoglobin subunit alpha 1	Homo sapiens	224-228
26786180-2	2016	STUDY FINDING: We identified two independent phenomena that lead to aberrant XCI patterns in female hPSC: a rapid loss of histone H3 lysine 27 trimethylation (H3K27me3) and long non-coding X-inactive specific transcript (XIST) expression during culture, often accompanied by erosion of XCI-specific methylation, and a frequent loss of random XCI in the cultures.	Lysine	133-139	PSC	Homo sapiens	100-104
29893854-5	2018	Parkin mediates the attachment of an atypical poly-ubiquitin chain to VPS35 with three lysine residues identified within the C-terminal region of VPS35 that are covalently modified by ubiquitin.	Lysine	87-93	VPS35 retromer complex component	Homo sapiens	70-75
27161704-2	2016	Plasmin can also degrade IgG thereby exposing C-terminal lysine residues.	Lysine	57-63	plasminogen	Homo sapiens	0-7
27161704-14	2016	CONCLUSIONS: C-terminal lysine residues which are formed as a result of degradation of native IgG with plasmin can bind to lysine binding sites on the kringle domains of Pg.	Lysine	24-30	plasminogen	Homo sapiens	103-110
27161704-14	2016	CONCLUSIONS: C-terminal lysine residues which are formed as a result of degradation of native IgG with plasmin can bind to lysine binding sites on the kringle domains of Pg.	Lysine	123-129	plasminogen	Homo sapiens	103-110
30527625-12	2019	Mechanistically, KDM4D catalyzed histone 3 on lysine 9 (H3K9) di-, and tri-demethylation, which promoted TLR4 expression, and subsequently prompted liver fibrogenesis by activating NF-kappaB signaling pathways.	Lysine	46-52	lysine demethylase 4D	Homo sapiens	17-22
29893854-5	2018	Parkin mediates the attachment of an atypical poly-ubiquitin chain to VPS35 with three lysine residues identified within the C-terminal region of VPS35 that are covalently modified by ubiquitin.	Lysine	87-93	VPS35 retromer complex component	Homo sapiens	146-151
30958363-5	2019	Therefore, it is pertinent to understand and link the role of various lysine residues along with their effector molecules, for instance, E3 ligases PARK2 and STUB1 in the ubiquitination cascade.	Lysine	70-76	STIP1 homology and U-box containing protein 1	Homo sapiens	158-163
30021117-0	2018	Rational engineering of ornithine decarboxylase with greater selectivity for ornithine over lysine through protein network analysis.	Lysine	92-98	ornithine decarboxylase 1	Homo sapiens	24-47
30850062-1	2019	Ubiquitin has seven lysines, all of which are used to generate polyubiquitin chains in the yeast Saccharomyces cerevisiae.	Lysine	20-27	ubiquitin	Saccharomyces cerevisiae S288C	0-9
27028653-3	2016	A point mutation at lysine 255 in human alpha-actinin-4 to glutamate increases the binding affinity resulting in stiffer cytoskeletal structures.	Lysine	20-26	actinin alpha 4	Homo sapiens	40-55
30021117-2	2018	However, ODC also has minor activity towards cell metabolite C6 lysine and yields C5 cadaverine.	Lysine	64-70	ornithine decarboxylase 1	Homo sapiens	9-12
30060157-5	2018	Our results show that GDF9 + BMP15 through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of histone 3 lysine 27 (H3K27ac), facilitating AMH/Amh expression.	Lysine	188-194	SMAD family member 2	Homo sapiens	60-67
26934656-5	2016	Here, we demonstrated that P300 binds to and increases histone H3 lysine 27 acetylation (H3K27Ac) in the FASN gene promoter.	Lysine	66-72	E1A binding protein p300	Homo sapiens	27-31
26973686-1	2016	One key role of the essential polyamine spermidine in eukaryotes is to provide the 4-aminobutyl moiety group destined to the post-translational modification of a lysine in the highly conserved translation factor eIF5A.	Lysine	162-168	eukaryotic elongation factor 5A-1	Arabidopsis thaliana	212-217
26973686-2	2016	This modification is catalyzed by two sequential enzymatic steps leading to the activation of eIF5A by the conversion of one conserved lysine to the unusual amino acid hypusine.	Lysine	135-141	eukaryotic elongation factor 5A-1	Arabidopsis thaliana	94-99
31395347-5	2019	An essential histone PTM involved in the DDR is histone methylation, which is regulated by histone methyltransferase (HMT) and histone demethylase (HDM) enzymes that add and remove methyl groups on lysine and arginine residues within proteins respectively.	Lysine	198-204	PR/SET domain 9	Homo sapiens	91-116
31395347-5	2019	An essential histone PTM involved in the DDR is histone methylation, which is regulated by histone methyltransferase (HMT) and histone demethylase (HDM) enzymes that add and remove methyl groups on lysine and arginine residues within proteins respectively.	Lysine	198-204	PR/SET domain 9	Homo sapiens	118-121
30156703-5	2019	In Arabidopsis, HISTONE MONOUBIQUITINATION2 (HUB2) mediates H2B monoubiquitination (H2Bub1), whereas SET DOMAIN GROUP8 (SDG8) catalyzes H3 lysine 36 trimethylation (H3K36me3).	Lysine	139-145	histone mono-ubiquitination 2	Arabidopsis thaliana	16-43
30156703-5	2019	In Arabidopsis, HISTONE MONOUBIQUITINATION2 (HUB2) mediates H2B monoubiquitination (H2Bub1), whereas SET DOMAIN GROUP8 (SDG8) catalyzes H3 lysine 36 trimethylation (H3K36me3).	Lysine	139-145	histone mono-ubiquitination 2	Arabidopsis thaliana	45-49
30060157-5	2018	Our results show that GDF9 + BMP15 through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of histone 3 lysine 27 (H3K27ac), facilitating AMH/Amh expression.	Lysine	188-194	E1A binding protein p300	Homo sapiens	117-121
26805559-1	2016	GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36.	Lysine	75-81	lysine (K)-specific demethylase 4C	Mus musculus	0-5
26805559-1	2016	GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36.	Lysine	75-81	lysine (K)-specific demethylase 4C	Mus musculus	21-26
30038214-3	2018	Recent genome-wide studies demonstrated that Treg have increased trimethylation on histone H3 at lysine 4 (H3K4me3) around the Treg master transcription factor, Foxp3 loci.	Lysine	97-103	forkhead box P3	Homo sapiens	161-166
26805559-1	2016	GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36.	Lysine	75-81	lysine (K)-specific demethylase 4C	Mus musculus	27-33
30093630-3	2019	Here, we report a novel cisplatin-resistance mechanism involving SET Domain Containing 2 (SETD2), a histone H3 lysine 36 (H3K36) trimethyltransferase, and cAMP-responsive element-binding protein 1 (CREB1).	Lysine	111-117	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	65-88
29980609-6	2018	In contrast, cytoplasmic lysines act as negative regulators targeting AICL for proteasomal degradation.	Lysine	25-32	C-type lectin domain family 2 member B	Homo sapiens	70-74
30093630-3	2019	Here, we report a novel cisplatin-resistance mechanism involving SET Domain Containing 2 (SETD2), a histone H3 lysine 36 (H3K36) trimethyltransferase, and cAMP-responsive element-binding protein 1 (CREB1).	Lysine	111-117	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	90-95
26806292-6	2016	Histone 3 lysine 4 dimethylation (H3K4me2, a histone modification for transcriptional activation) in the Sox9 promoter region was decreased with age, which was associated with the age-dependent decrease in SOX9 expression in ACs.	Lysine	10-16	SRY (sex determining region Y)-box 9	Mus musculus	105-109
26806292-7	2016	Knockdown of lysine-specific demethylase-1 up-regulated SOX9 expression in ACs of adult mice through increased recruitment of H3K4me2 in the Sox9 promoter region.	Lysine	13-19	SRY (sex determining region Y)-box 9	Mus musculus	56-60
26806292-7	2016	Knockdown of lysine-specific demethylase-1 up-regulated SOX9 expression in ACs of adult mice through increased recruitment of H3K4me2 in the Sox9 promoter region.	Lysine	13-19	SRY (sex determining region Y)-box 9	Mus musculus	141-145
30089272-5	2018	Mechanistically, PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca2+ overload.	Lysine	84-90	E1A binding protein p300	Homo sapiens	45-49
26589234-10	2016	Knockdown of lysine (K)-specific demethylase 5B (KDM5B), or inhibition of DNA (Cytosine-5-)-methyltransferase 1 (DNMT1) caused up-regulation of IL-12.	Lysine	13-19	lysine demethylase 5B	Homo sapiens	49-54
30542727-1	2019	Suppressor of variegation 3-9 homologue 2 (SUV39H2), a SET domain-containing histone methyl-transferase, trimethylates histone H3 at lysine 9 and serves crucial roles in heterochromatin organization and genome stability.	Lysine	133-139	SUV39H2 histone lysine methyltransferase	Homo sapiens	0-41
30542727-1	2019	Suppressor of variegation 3-9 homologue 2 (SUV39H2), a SET domain-containing histone methyl-transferase, trimethylates histone H3 at lysine 9 and serves crucial roles in heterochromatin organization and genome stability.	Lysine	133-139	SUV39H2 histone lysine methyltransferase	Homo sapiens	43-50
30309983-9	2018	In an accompanying paper, we further report that mutation of these lysine residues diminishes Gag assembly on the PM and inhibits ASV particle release.	Lysine	67-73	Pr55(Gag)	Human immunodeficiency virus 1	94-97
30051891-9	2018	Conservation of the Clr4 autoregulatory loop in other H3K9 methyltransferases and the automethylation of a corresponding lysine in the human SUV39H2 homologue16 suggest that the mechanism described here is broadly conserved.	Lysine	121-127	SUV39H2 histone lysine methyltransferase	Homo sapiens	141-148
30254011-1	2018	Histone H2B lysine 123 mono-ubiquitination (H2Bub1), catalyzed by Rad6 and Bre1 in Saccharomyces cerevisiae, modulates chromatin structure and affects diverse cellular functions.	Lysine	12-18	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	75-79
26503246-4	2016	We identify two proteins whose depletion prevents developmental loss of CenH3: the domesticated transposase Pgm involved in the formation of DNA double strand cleavages and the Polycomb-like lysine methyltransferase Ezl1 necessary for trimethylation of histone H3 on lysine 9 and lysine 27.	Lysine	191-197	centromere protein A	Homo sapiens	72-77
26503246-4	2016	We identify two proteins whose depletion prevents developmental loss of CenH3: the domesticated transposase Pgm involved in the formation of DNA double strand cleavages and the Polycomb-like lysine methyltransferase Ezl1 necessary for trimethylation of histone H3 on lysine 9 and lysine 27.	Lysine	267-273	centromere protein A	Homo sapiens	72-77
29932303-0	2018	Quantitative Crotonylome Analysis Expands the Roles of p300 in the Regulation of Lysine Crotonylation Pathway.	Lysine	81-87	E1A binding protein p300	Homo sapiens	55-59
26655717-9	2016	Inhibition of CK2 results in increased binding of the Ikaros-HDAC1 complex to the promoter of JARID1B, with increased formation of trimethylated histone H3 lysine 27 and decreased histone H3 Lys-9 acetylation.	Lysine	156-162	IKAROS family zinc finger 1	Homo sapiens	54-60
30404815-7	2018	Besides, the KLF4 binding regions on IL-23 or IL-36a promoters and the KLF4 lysine site acetylated by PCAF were identified.	Lysine	76-82	lysine acetyltransferase 2B	Rattus norvegicus	102-106
30291936-8	2018	MET formed covalent bonds with ZO-2 in serine, tyrosine and lysine residues.	Lysine	60-66	tight junction protein 2	Mus musculus	31-35
29932303-2	2018	The p300-catalyzed histone Kcr is able to stimulate transcription to a greater degree than the well-studied histone lysine acetylation (Kac).	Lysine	116-122	E1A binding protein p300	Homo sapiens	4-8
30291936-10	2018	MET bonds formed at ZO-2 ubiquitination sites likely interfere with ZO-2 degradation and TJ sealing, based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue.	Lysine	202-208	tight junction protein 2	Mus musculus	20-24
30291936-10	2018	MET bonds formed at ZO-2 ubiquitination sites likely interfere with ZO-2 degradation and TJ sealing, based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue.	Lysine	202-208	tight junction protein 2	Mus musculus	68-72
30291936-10	2018	MET bonds formed at ZO-2 ubiquitination sites likely interfere with ZO-2 degradation and TJ sealing, based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue.	Lysine	202-208	tight junction protein 2	Mus musculus	68-72
26804915-2	2016	KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID) patients.	Lysine	20-26	lysine demethylase 5C	Homo sapiens	0-5
29932303-4	2018	Here, a quantitative proteomics study to characterize the p300-regulated lysine crotonylome is reported.	Lysine	73-79	E1A binding protein p300	Homo sapiens	58-62
29932303-8	2018	Taken together, this study reveals the lysine crotonylome in response to p300, which sheds light on the role for lysine crotonylation in regulation of diverse cellular processes and provides new insights into mechanisms of p300 functions.	Lysine	39-45	E1A binding protein p300	Homo sapiens	73-77
26626994-10	2016	Without its C terminus, alpha2AP can no longer bind to the lysine binding sites of plasmin(ogen) and is only a kinetically slow plasmin inhibitor.	Lysine	59-65	plasminogen	Homo sapiens	83-90
29957475-1	2018	An activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrinolysis by removing C-terminal lysine/arginine residues from partially degraded fibrin.	Lysine	112-118	carboxypeptidase B2	Homo sapiens	13-56
26787900-3	2016	Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the lysine 433 residue.	Lysine	93-99	pyruvate kinase, muscle	Mus musculus	60-64
26787900-3	2016	Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the lysine 433 residue.	Lysine	93-99	pyruvate kinase, muscle	Mus musculus	66-84
30389849-6	2018	We show that de novo PcG recruitment follows a temporal hierarchy in which PhoRC stably localizes at the target gene at least 1 h before stable recruitment of PRC2 and concurrent trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	211-217	Polycomb	Drosophila melanogaster	21-24
30282802-1	2018	OTUB1 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains and also regulates ubiquitin signaling through a unique, noncatalytic mechanism.	Lysine	48-51	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	0-5
30140388-9	2018	Mechanistically, HERC1 controls C-RAF stability by regulating its polyubiquitylation in a lysine 48-linked chain.	Lysine	90-96	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	32-37
26403849-4	2016	The widely expressed SLC25A2 transported ADMA across the liposomal membrane in both directions by both unidirectional transport and exchange against arginine or lysine.	Lysine	161-167	solute carrier family 25 member 2	Homo sapiens	21-28
30427828-3	2018	Here, we show that a membrane-snorkeling Lys residue in integrin alphaLbeta2 (also known as lymphocyte function-associated antigen 1 [LFA-1]) regulates transmembrane heterodimer formation and integrin adhesion through ionic interplay with acidic phospholipids and calcium ions (Ca2+) in T cells.	Lysine	41-44	integrin subunit alpha L	Homo sapiens	92-132
29842882-1	2018	SETD2 is a histone methyltransferase that catalyzes the trimethylation of lysine 36 on histone 3.	Lysine	74-80	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
30427828-3	2018	Here, we show that a membrane-snorkeling Lys residue in integrin alphaLbeta2 (also known as lymphocyte function-associated antigen 1 [LFA-1]) regulates transmembrane heterodimer formation and integrin adhesion through ionic interplay with acidic phospholipids and calcium ions (Ca2+) in T cells.	Lysine	41-44	integrin subunit alpha L	Homo sapiens	134-139
30408026-7	2018	TRIM59 stabilized PDCD10 by suppressing RING finger and transmembrane domain-containing protein 1 (RNFT1)-induced lysine 63 (K63) ubiquitination and subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation.	Lysine	114-120	ring finger protein, transmembrane 1	Homo sapiens	40-97
30408026-7	2018	TRIM59 stabilized PDCD10 by suppressing RING finger and transmembrane domain-containing protein 1 (RNFT1)-induced lysine 63 (K63) ubiquitination and subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation.	Lysine	114-120	ring finger protein, transmembrane 1	Homo sapiens	99-104
26731476-6	2016	ETV1 facilitated the recruitment of JMJD2A to the YAP1 promoter, leading to changes in histone lysine methylation in a human prostate cancer cell line.	Lysine	95-101	Yes1 associated transcriptional regulator	Homo sapiens	50-54
30498568-6	2018	This severing of the DNA damage checkpoint signaling pathway was reported to stem from exclusion of histone H4 lysine 20 dimethylation (H4K20me2) from telomeric nucleosomes in both wild type cells and cells lacking Taz1.	Lysine	111-117	lysophosphatidylcholine acyltransferase	Saccharomyces cerevisiae S288C	215-219
26614682-11	2016	The 1.22% lysine exhibited highest expression of ionotropic glutamate receptor, while brain ghrelin receptor expression was highest at 0.86 and 0.92% lysine.	Lysine	150-156	growth hormone secretagogue receptor	Homo sapiens	92-108
27303701-0	2016	Reconfiguration of Transcriptional Control of Lysine Biosynthesis in Candida albicans Involves a Central Role for the Gcn4 Transcriptional Activator.	Lysine	46-52	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	118-122
27303701-6	2016	Whereas Gcn4 is dispensable for the growth of S. cerevisiae under lysine deprivation conditions, it is an essential regulator required for the growth of C. albicans under these conditions, as gcn4 deletion caused lysine auxotrophy.	Lysine	213-219	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	192-196
30405132-3	2018	Here we show that NOD2 signaling involves conjugation of RIP2 with lysine 63 (K63), K48 and M1 polyubiquitin chains, as well as with non-canonical K27 chains.	Lysine	67-73	nucleotide-binding oligomerization domain containing 2	Mus musculus	18-22
30213795-5	2018	Furthermore, we demonstrate that SIRT2 regulates p73 transcriptional activity by deacetylation of its C-terminal lysine residues.	Lysine	113-119	tumor protein p73	Homo sapiens	49-52
27303701-8	2016	Under lysine or isoleucine-valine deprivation conditions, Gcn4 recruitment to LYS2 and LYS9 promoters was induced in C. albicans.	Lysine	6-12	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	58-62
29707871-7	2018	Low dietary lysine caused reduction in serum glucose levels (p &lt; .05) and serum insulin levels (p = .0613).	Lysine	12-18	insulin	Sus scrofa	83-90
27303701-10	2016	Thus, the transcriptional rewiring of the lysine biosynthetic pathway in C. albicans involves not only neofunctionalization of the four LYS14-like genes but the attendant strengthening of control by Gcn4, indicating a coordinated response with a much broader scope for control of amino acid biosynthesis in this human pathogen.	Lysine	42-48	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	199-203
27303701-14	2016	We found that Gcn4 is an essential and direct transcriptional regulator of the expression of lysine biosynthetic genes under lysine starvation conditions in C. albicans.	Lysine	93-99	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	14-18
27303701-14	2016	We found that Gcn4 is an essential and direct transcriptional regulator of the expression of lysine biosynthetic genes under lysine starvation conditions in C. albicans.	Lysine	125-131	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	14-18
27303701-15	2016	Our results therefore suggest that the regulation of the lysine biosynthetic pathway in Candida clade genomes involves gain of function by the master transcriptional regulator Gcn4, coincident with the neofunctionalization of the S. cerevisiae pathway-specific regulator Lys14.	Lysine	57-63	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	176-180
30217796-2	2018	We investigated the roles in epigenetic inheritance of MES-4 and MET-1, the two Caenorhabditis elegans enzymes that methylate H3K36 (histone H3 Lys 36).	Lysine	144-147	Histone-lysine N-methyltransferase mes-4	Caenorhabditis elegans	55-60
30100102-5	2018	As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63-linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity.	Lysine	134-140	interferon regulatory factor 3	Homo sapiens	72-76
30100102-5	2018	As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63-linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity.	Lysine	134-140	interferon regulatory factor 3	Homo sapiens	129-133
30100102-5	2018	As a deubiquitinase, OTUD1 directly interacts with transcription factor IRF3 and removes the K63-linked poly-ubiquitin chains on IRF3 Lysine 98, which inhibits IRF3 nuclear translocation and transcriptional activity.	Lysine	134-140	interferon regulatory factor 3	Homo sapiens	129-133
26675261-6	2016	Our further studies revealed that lysine residues including K71, K287, K367 and K471 were essential for Mps1 sumoylation.	Lysine	34-40	TTK protein kinase	Homo sapiens	104-108
30448236-6	2018	Furtherly, inhibition of SphK2 inactivated STAT3 by decreasing both phosphorylation on Tyr705 and acetylation on lysine residue, and led to stimulation of PEPCK and G6Pase expression.	Lysine	113-119	sphingosine kinase 2	Homo sapiens	25-30
26503960-11	2016	Indeed, we define the acetylation status of the Lys 80 residue located in the DNA-binding domain of HSF1 as a critical factor in modulating HSF1 protein stability in addition to its previously identified role in the transcriptional activity.	Lysine	48-51	heat shock transcription factor 1	Homo sapiens	100-104
26503960-11	2016	Indeed, we define the acetylation status of the Lys 80 residue located in the DNA-binding domain of HSF1 as a critical factor in modulating HSF1 protein stability in addition to its previously identified role in the transcriptional activity.	Lysine	48-51	heat shock transcription factor 1	Homo sapiens	140-144
29928411-1	2018	Jumonji AT-rich interactive domain 1B (JARID1B) has been revealed to remove methyl residues from methylated lysine 4 on histone H3 (H3K4) and has also been reported to be associated with the progression of numerous types of tumor.	Lysine	108-114	lysine demethylase 5B	Homo sapiens	0-37
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	63-66	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	56-59
30253095-3	2018	In the case of bromodomains, which recognize N-epsilon-acetylated lysine, selective inhibition of individual bromodomain-and-extra-terminal (BET)-family bromodomains has proven challenging.	Lysine	66-72	delta/notch like EGF repeat containing	Homo sapiens	141-144
30135206-5	2018	The mechanism consists of an IFN-induced, Bcl3- and p300-dependent PD-L1 promoter occupancy by Lys-314/315 acetylated p65 NF-kappaB.	Lysine	95-98	E1A binding protein p300	Homo sapiens	52-56
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	56-59
29928411-1	2018	Jumonji AT-rich interactive domain 1B (JARID1B) has been revealed to remove methyl residues from methylated lysine 4 on histone H3 (H3K4) and has also been reported to be associated with the progression of numerous types of tumor.	Lysine	108-114	lysine demethylase 5B	Homo sapiens	39-46
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	56-59
29653907-1	2018	BACKGROUND: Mutations in Lysine-Specific Histone Methyltransferase 2B gene (KMT2B) have been reported to be associated with complex early-onset dystonia.	Lysine	25-31	lysine methyltransferase 2B	Homo sapiens	76-81
26482291-9	2016	Strikingly, lysine residues are targeted by a particularly high number of PTMs including acetylation, methylation, ubiquitination and sumoylation.	Lysine	12-18	parathymosin	Homo sapiens	74-78
26482291-14	2016	This characteristic, together with the diversity of lysine PTMs, suggests that many other lysine modifications may still remain unidentified, raising the intriguing possibility that lysine PTMs may be the major means by which signalling pathways modify protein behaviour.	Lysine	90-96	parathymosin	Homo sapiens	189-193
29654578-6	2018	Computational analyses proposed that glutamine at position 226 is an important, evolutionary conserved amino acid while the substitution with lysine probably disturbs tertiary protein structure and impacts posttranslational PAH modifications.	Lysine	142-148	phenylalanine hydroxylase	Homo sapiens	224-227
30279144-4	2018	METHODS: The hepatic SIRT5-overexpressing ob/ob mouse model (ob/ob-SIRT5 OE) was established by CRISPR/Cas9 gene editing tool Protein malonylation and succinylation lysine sites were identified by immunoprecipitation coupled lipid chromatography - tandem mass spectrometry (LC-MS/MS) methods.	Lysine	165-171	sirtuin 5	Mus musculus	21-26
26482291-14	2016	This characteristic, together with the diversity of lysine PTMs, suggests that many other lysine modifications may still remain unidentified, raising the intriguing possibility that lysine PTMs may be the major means by which signalling pathways modify protein behaviour.	Lysine	90-96	parathymosin	Homo sapiens	189-193
29944992-4	2018	Mutation and western blot analyses demonstrated in IAIi001RSTS2-65-A the patient"s specific non sense mutation in exon 23 c.3829A &gt; T, p.(Lys 1277*) and showed reduced quantity of wild type p300 protein.	Lysine	141-144	E1A binding protein p300	Homo sapiens	193-197
26635020-1	2016	Sirtuin 5 (SIRT5) is a member of the sirtuin family of protein deacylases that catalyzes removal of post-translational modifications, such as succinyl and malonyl moieties, on lysine residues.	Lysine	176-182	sirtuin 5	Homo sapiens	0-9
26635020-1	2016	Sirtuin 5 (SIRT5) is a member of the sirtuin family of protein deacylases that catalyzes removal of post-translational modifications, such as succinyl and malonyl moieties, on lysine residues.	Lysine	176-182	sirtuin 5	Homo sapiens	11-16
30118695-14	2018	We establish that TRIM25 ubiquitinates MTA-1 at lysine 98 and degrades it normal liver cells.	Lysine	48-54	tripartite motif containing 25	Homo sapiens	18-24
29724720-3	2018	We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysine 36 (H3K36me3) and is located in the 3p deletion, to also trimethylate microtubules on lysine 40 (alphaTubK40me3) during mitosis, with alphaTubK40me3 required for genomic stability.	Lysine	83-89	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	41-46
29994125-3	2018	Experimental identification of lysine glutarylation sites was founded in 2014 and also identified its deglutarylase sirturn 5(SIRT 5).	Lysine	31-37	sirtuin 5	Homo sapiens	126-132
26545016-1	2016	The aim of this work was to synthesize Lys(1)(alpha,gamma-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR).	Lysine	39-42	gastrin releasing peptide receptor	Mus musculus	261-296
26545016-1	2016	The aim of this work was to synthesize Lys(1)(alpha,gamma-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR).	Lysine	39-42	gastrin releasing peptide receptor	Mus musculus	298-302
26545016-1	2016	The aim of this work was to synthesize Lys(1)(alpha,gamma-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR).	Lysine	66-69	gastrin releasing peptide receptor	Mus musculus	261-296
26545016-1	2016	The aim of this work was to synthesize Lys(1)(alpha,gamma-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR).	Lysine	66-69	gastrin releasing peptide receptor	Mus musculus	298-302
29724720-3	2018	We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysine 36 (H3K36me3) and is located in the 3p deletion, to also trimethylate microtubules on lysine 40 (alphaTubK40me3) during mitosis, with alphaTubK40me3 required for genomic stability.	Lysine	176-182	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	41-46
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Lysine	77-83	tripartite motif containing 26	Homo sapiens	20-26
26554862-1	2016	Homozygous Hb E [beta26(B8)Glu Lys; HBB: c.79G &gt; A] is a clinically mild disease with no significant symptoms.	Lysine	31-34	hemoglobin subunit epsilon 1	Homo sapiens	11-15
30112781-1	2018	The present study describes the synthesis and biological studies of a small series of head-to-tail cyclic tetrapeptides of the general structure c(Lys-beta2,2 -Xaa-Lys) containing one lipophilic beta2,2 -amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence.	Lysine	147-150	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	151-158
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Lysine	222-228	tripartite motif containing 26	Homo sapiens	20-26
27246205-3	2016	HDAC2 has been shown to be modified by SUMO1 at lysine 462.	Lysine	48-54	small ubiquitin like modifier 1	Homo sapiens	39-44
29754817-4	2018	Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively.	Lysine	41-47	bromodomain containing 7	Mus musculus	79-83
26545399-2	2016	Here, we report a new eukaryotic protein N-terminal methyltransferase, Saccharomyces cerevisiae YLR285W, which methylates eEF1A at a previously undescribed high-stoichiometry N-terminal site and the adjacent lysine.	Lysine	208-214	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	122-127
26545399-8	2016	This study also reports that the trimethylation of Lys(79) in eEF1A is conserved from yeast to human.	Lysine	51-54	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	62-67
30035374-3	2018	In this pathway, the aminotransferase AGD2-like defense response protein (ALD1) alpha-transaminates l-lysine and generates cyclic dehydropipecolic (DP) intermediates that are subsequently reduced to pipecolic acid (Pip) by the reductase SAR-deficient 4 (SARD4).	Lysine	100-108	AGD2-like defense response protein 1	Arabidopsis thaliana	74-78
29883318-5	2018	Especially, trypsin-1 slightly favored lysine over arginine in this position, while trypsin-3 did not discriminate between them.	Lysine	39-45	serine protease 1	Homo sapiens	12-21
26545399-9	2016	The methyltransferase responsible for Lys(79) methylation of human eEF1A is shown to be N6AMT2, previously documented as a putative N(6)-adenine-specific DNA methyltransferase.	Lysine	38-41	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	67-72
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	92-96
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	263-267
30181289-2	2018	We demonstrate that substituting H3G34 with arginine, valine, or aspartate (H3G34R/V/D), which converts the non-side chain glycine to a large side chain-containing residue, blocks H3 lysine 36 (H3K36) dimethylation and trimethylation by histone methyltransferases, including SETD2, an H3K36-specific trimethyltransferase.	Lysine	183-189	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	275-280
26845769-5	2016	A molecular model was built of the complex and associated bioinformatics analyses predicted that the interaction is likely to involve an electrostatic interaction between Lys-240 of alpha-actin and Glu-30 of CHD1.	Lysine	171-174	chromodomain helicase DNA binding protein 1	Homo sapiens	208-212
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2B	Homo sapiens	92-96
30263097-5	2018	Because the acetyltransferase p300 was found to acetylate STAT3 on lysine 685 residues, we wondered whether p300 acetylates STAT3 in CLL cells.	Lysine	67-73	E1A binding protein p300	Homo sapiens	30-34
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2B	Homo sapiens	263-267
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	238-241	lysine acetyltransferase 2B	Homo sapiens	92-96
30097555-4	2018	We show that SCML2 accumulates on pericentromeric heterochromatin (PCH) in male germ cells, where it suppresses PRC1-mediated monoubiquitylation of histone H2A at Lysine 119 (H2AK119ub) and promotes deposition of PRC2-mediated H3K27me3 during meiosis.	Lysine	163-169	Scm polycomb group protein like 2	Homo sapiens	13-18
26450986-3	2015	A missense mutation from methionine to lysine in the cytoplasmic tail of Kcc1 impairs phosphorylation of adjacent threonines required for inhibiting cotransporter activity.	Lysine	39-45	solute carrier family 12, member 4	Mus musculus	73-77
29629903-7	2018	ZMYND8 acetylation at lysines 1007 and 1034 by p300 is required for HIF activation and breast cancer progression and metastasis.	Lysine	22-29	E1A binding protein p300	Homo sapiens	47-51
26551685-3	2015	Here, we determined that JARID1C binds broadly to chromatin domains characterized by the trimethylation of lysine 9 (H3K9me3), which is a histone mark enriched in heterochromatin.	Lysine	107-113	lysine demethylase 5C	Homo sapiens	25-32
25791343-0	2015	Epigenetic regulation of polyomavirus JC involves acetylation of specific lysine residues in NF-kappaB p65.	Lysine	74-80	RELA proto-oncogene, NF-kB subunit	Homo sapiens	103-106
30097555-4	2018	We show that SCML2 accumulates on pericentromeric heterochromatin (PCH) in male germ cells, where it suppresses PRC1-mediated monoubiquitylation of histone H2A at Lysine 119 (H2AK119ub) and promotes deposition of PRC2-mediated H3K27me3 during meiosis.	Lysine	163-169	protein regulator of cytokinesis 1	Homo sapiens	112-116
29063269-7	2018	CONCLUSIONS: The ADH1B Arg/Arg genotype and the ALDH2 Glu/Lys genotype were positive determinants of fatty liver in the subjects.	Lysine	58-61	aldehyde dehydrogenase 2 family member	Homo sapiens	48-53
29795359-3	2018	SMARCA2 is multi-domain protein containing a bromodomain (BRD) that specifically recognizes acetylated lysine residues in histone tails, thus playing an important role in chromatin remodeling.	Lysine	103-109	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	0-7
25791343-6	2015	A site-directed mutagenesis strategy was employed targeting the known lysine acetylation sites of NF-kappaB p65: K218, K221, and K310.	Lysine	70-76	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-111
28489470-11	2018	Proteomic analyses of the high molecular weight (&gt;3 kDa) fraction of exposed rabbit BAL fluid identified HDI modification of specific lysines in uteroglobin (aka clara cell protein) and albumin.	Lysine	137-144	uteroglobin	Oryctolagus cuniculus	148-159
25400040-5	2015	p28(GANK) interacted with p300 to attenuate assembly of RelA with p300, which lessened acetylation of RelA on the lysine 310 sites.	Lysine	114-120	E1A binding protein p300	Homo sapiens	26-30
25400040-5	2015	p28(GANK) interacted with p300 to attenuate assembly of RelA with p300, which lessened acetylation of RelA on the lysine 310 sites.	Lysine	114-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-60
25400040-5	2015	p28(GANK) interacted with p300 to attenuate assembly of RelA with p300, which lessened acetylation of RelA on the lysine 310 sites.	Lysine	114-120	E1A binding protein p300	Homo sapiens	66-70
25400040-5	2015	p28(GANK) interacted with p300 to attenuate assembly of RelA with p300, which lessened acetylation of RelA on the lysine 310 sites.	Lysine	114-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	102-106
26391951-5	2015	We further show that the principal mechanism for chromatin loading of SMCHD1 involves an LRIF1-mediated interaction with HP1gamma at trimethylated histone H3 lysine 9 (H3K9me3)-modified chromatin sites on the chromosome arms.	Lysine	158-164	chromobox 3	Homo sapiens	121-129
29902489-8	2018	In contrast, the SUFA1 and IBA57.2 plastidial isoforms cannot rescue the lysine and glutamate auxotrophies of the respective isa1-isa2Delta and iba57Delta strains or of the isa1-isa2-iba57Delta triple mutant when expressed in combination.	Lysine	73-79	Iba57p	Saccharomyces cerevisiae S288C	27-32
29920190-1	2018	Lysine-63-linked (K63-linked) polyubiquitination of TRAF3 coordinates the engagement of pattern-recognition receptors with recruited adaptor proteins and downstream activator TBK1 in pathways that induce type I IFN.	Lysine	0-6	TANK-binding kinase 1	Mus musculus	175-179
29581290-1	2018	The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport.	Lysine	12-18	oxidative stress responsive kinase 1	Homo sapiens	113-142
30120232-6	2018	SUMOylation at lysine 1270 retains VEGFR2 in the Golgi and reduces its surface expression, attenuating VEGFR2-dependent signalling.	Lysine	15-21	kinase insert domain protein receptor	Mus musculus	35-41
30120232-6	2018	SUMOylation at lysine 1270 retains VEGFR2 in the Golgi and reduces its surface expression, attenuating VEGFR2-dependent signalling.	Lysine	15-21	kinase insert domain protein receptor	Mus musculus	103-109
26347501-2	2015	Herein, we demonstrate CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like cells by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3).	Lysine	178-184	urothelial cancer associated 1	Homo sapiens	23-27
29581290-1	2018	The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport.	Lysine	12-18	oxidative stress responsive kinase 1	Homo sapiens	144-148
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Lysine	164-167	cyclin dependent kinase 2	Homo sapiens	196-200
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	RELA proto-oncogene, NF-kB subunit	Homo sapiens	169-172
29932303-8	2018	Taken together, this study reveals the lysine crotonylome in response to p300, which sheds light on the role for lysine crotonylation in regulation of diverse cellular processes and provides new insights into mechanisms of p300 functions.	Lysine	39-45	E1A binding protein p300	Homo sapiens	223-227
29932303-8	2018	Taken together, this study reveals the lysine crotonylome in response to p300, which sheds light on the role for lysine crotonylation in regulation of diverse cellular processes and provides new insights into mechanisms of p300 functions.	Lysine	113-119	E1A binding protein p300	Homo sapiens	73-77
26618351-7	2015	To characterize this interaction between sGC and PDI, we first identified peptide linkages between sGC and PDI, using a lysine cross-linking reagent and recently developed mass spectrometry analysis.	Lysine	120-126	prolyl 4-hydroxylase subunit beta	Homo sapiens	107-110
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	RELA proto-oncogene, NF-kB subunit	Homo sapiens	173-177
26596471-4	2015	Mechanistic studies show that SENP1 deletion in adipocytes enhances SUMOylation of the NF-kappaB essential molecule, NEMO, at lysine 277/309, leading to increased NF-kappaB activity, cytokine production and pancreatic inflammation.	Lysine	126-132	SUMO1/sentrin specific peptidase 1	Mus musculus	30-35
26424795-4	2015	Studies presented here demonstrate that CPS1 is a bona fide nuclear protein involved in homocitrullination (hcit), including a key lysine residue on histone H1 (H1K34hcit).	Lysine	131-137	carbamoyl-phosphate synthase 1	Homo sapiens	40-44
29932303-8	2018	Taken together, this study reveals the lysine crotonylome in response to p300, which sheds light on the role for lysine crotonylation in regulation of diverse cellular processes and provides new insights into mechanisms of p300 functions.	Lysine	113-119	E1A binding protein p300	Homo sapiens	223-227
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	delta/notch like EGF repeat containing	Homo sapiens	213-216
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	delta/notch like EGF repeat containing	Homo sapiens	286-289
29176272-10	2018	The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated.	Lysine	96-99	aldehyde dehydrogenase 2 family member	Homo sapiens	86-91
25728682-2	2015	SETD2 (Su(var), Enhancer of zeste, Trithorax-domain containing 2) trimethylates histone-3 lysine-36 (H3K36me3) at sites of active transcription and is mutated in diverse tumour types, including clear cell renal carcinomas (ccRCCs).	Lysine	90-96	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
30054464-0	2018	Versatility of ARD1/NAA10-mediated protein lysine acetylation.	Lysine	43-49	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	15-19
29503074-3	2018	We show that Pragmin contains a classical protein-kinase fold devoid of catalytic activity, despite a conserved catalytic lysine (K997).	Lysine	122-128	PEAK1 related, kinase-activating pseudokinase 1	Homo sapiens	13-20
30054464-0	2018	Versatility of ARD1/NAA10-mediated protein lysine acetylation.	Lysine	43-49	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	20-25
30054464-6	2018	ARD1-mediated lysine acetylation is a key switch that regulates the enzymatic activities and biological functions of proteins and influences cell biology from development to pathology.	Lysine	14-20	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	0-4
30054464-7	2018	In this review, we summarize protein lysine acetylation mediated by ARD1 and describe the biological meanings of this modification.	Lysine	37-43	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	68-72
26522327-4	2015	SIRT1 directly interacted with HMGB1 via its N-terminal lysine residues (28-30), and thereby inhibited HMGB1 release to improve survival in an experimental model of sepsis.	Lysine	56-62	high mobility group box 1	Mus musculus	31-36
29477861-8	2018	Protein homology modelling suggested that the PLG-rSmVAL18 interaction was mediated by lysine residues of the protein.	Lysine	87-93	plasminogen	Homo sapiens	46-49
26385180-4	2015	After five days of treatment with 100 nM ghrelin, TH-EGFP neurons exhibited significantly more and longer neurites than control treated neurons, and the effects of ghrelin were abolished by 100 muM ghrelin antagonist, D-Lys-GHRP-6.	Lysine	220-223	ghrelin	Mus musculus	41-48
26385180-4	2015	After five days of treatment with 100 nM ghrelin, TH-EGFP neurons exhibited significantly more and longer neurites than control treated neurons, and the effects of ghrelin were abolished by 100 muM ghrelin antagonist, D-Lys-GHRP-6.	Lysine	220-223	ghrelin	Mus musculus	164-171
26385180-4	2015	After five days of treatment with 100 nM ghrelin, TH-EGFP neurons exhibited significantly more and longer neurites than control treated neurons, and the effects of ghrelin were abolished by 100 muM ghrelin antagonist, D-Lys-GHRP-6.	Lysine	220-223	ghrelin	Mus musculus	164-171
30026560-8	2018	Together, these results identify PRMT5 as critical for oligodendrocyte differentiation and developmental myelination by modulating the cross-talk between histone arginine methylation and lysine acetylation.	Lysine	187-193	protein arginine N-methyltransferase 5	Mus musculus	33-38
29366606-1	2018	PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes.	Lysine	119-126	PR/SET domain 9	Homo sapiens	0-5
30016622-5	2018	In neurons and in vitro single-molecule motility assays, SEPT9 suppresses kinesin-1/KIF5 and enhances kinesin-3/KIF1 in a manner that depends on a lysine-rich loop of the kinesin motor domain.	Lysine	147-153	septin 9	Homo sapiens	57-62
29764757-4	2018	Structural studies have identified key interactions with a conserved lysine residue and have highlighted potential regions of MPS1 which could be targeted to improve activity and selectivity.	Lysine	69-75	TTK protein kinase	Homo sapiens	126-130
26469956-7	2015	Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter.	Lysine	232-238	microRNA 205	Homo sapiens	121-128
26469956-7	2015	Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter.	Lysine	232-238	microRNA 205	Homo sapiens	270-277
29764865-6	2018	HP1gamma and its binding activity to methylated histone H3 lysine 9 were required for the proliferation, colony formation, and migration of lung adenocarcinoma cells.	Lysine	59-65	chromobox 3	Homo sapiens	0-8
29780501-3	2018	One key signal integrator is the histone variant H2A.X, which is phosphorylated at a C-terminal serine (S139ph), and ubiquitylated within its N-terminal tail at lysines 13 and 15 (K13/15ub).	Lysine	161-168	H2A.X variant histone	Homo sapiens	49-54
29866816-3	2018	Engineering of APC by site-directed mutagenesis provided a signaling selective APC mutant with 3 Lys residues replaced by 3 Ala residues, 3K3A-APC, that lacks &gt;90% anticoagulant activity but retains normal cell signaling activities.	Lysine	97-100	APC regulator of WNT signaling pathway	Homo sapiens	15-18
29866816-3	2018	Engineering of APC by site-directed mutagenesis provided a signaling selective APC mutant with 3 Lys residues replaced by 3 Ala residues, 3K3A-APC, that lacks &gt;90% anticoagulant activity but retains normal cell signaling activities.	Lysine	97-100	APC regulator of WNT signaling pathway	Homo sapiens	79-82
29866816-3	2018	Engineering of APC by site-directed mutagenesis provided a signaling selective APC mutant with 3 Lys residues replaced by 3 Ala residues, 3K3A-APC, that lacks &gt;90% anticoagulant activity but retains normal cell signaling activities.	Lysine	97-100	APC regulator of WNT signaling pathway	Homo sapiens	79-82
26456755-4	2015	Here, we show in budding yeast that Lys-362 and Arg-367 residues of the largest subunit (Orc1), both outside the aforementioned domains, are crucial for specific binding of ORC to origin DNA.	Lysine	36-39	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	89-93
26456755-8	2015	Lys-362 and Arg-367 residues of Orc1 are highly conserved among eukaryotic ORCs, but not in eubacterial and archaeal orthologs, suggesting a eukaryote-specific mechanism underlying recognition of replication origins by ORC.	Lysine	0-3	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	32-36
26605136-3	2015	Loss-of-function mutations in the analogous lysine of human erythroid ALAS (ALAS2) cause X-linked sideroblastic anemia.	Lysine	44-50	5'-aminolevulinate synthase 2	Homo sapiens	70-74
26605136-3	2015	Loss-of-function mutations in the analogous lysine of human erythroid ALAS (ALAS2) cause X-linked sideroblastic anemia.	Lysine	44-50	5'-aminolevulinate synthase 2	Homo sapiens	76-81
29535398-6	2018	C/EBP-alpha acetylation was determined in HSC lines in the presence or absence of TSA, and the lysine residue K276 was identified as a main acetylation site in C/EBP-alpha protein.	Lysine	95-101	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	160-171
26507377-7	2015	Also for other small GTPases such as Ras, Rho, Cdc42, and for many effectors and regulators thereof, lysine-acetylation sites were discovered.	Lysine	101-107	cell division cycle 42	Homo sapiens	47-52
29358331-2	2018	SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis.	Lysine	26-32	SET domain containing (lysine methyltransferase) 7	Mus musculus	84-88
25288139-6	2015	Specifically, deacetylation of histone 3 at lysine 9 (H3K9), through the coordinated action of the NAD+-dependent protein deacetylase sirtuin-6 (SIRT6) and nuclear factor kappa B (NFkappaB), sequesters GR expression leading to disinhibition of CRF.	Lysine	44-50	sirtuin 6	Homo sapiens	134-143
29970601-7	2018	In addition, lysine motifs were necessary for promoting the S-nitrosylation of HDAC2 and methyl-CpG binding protein 3 (MBD3).	Lysine	13-19	histone deacetylase 2	Rattus norvegicus	79-84
29627904-0	2018	Site-specific derivatization of human interferon beta-1a at lysine residues using microbial transglutaminase.	Lysine	60-66	transglutaminase 1	Homo sapiens	92-108
25288139-6	2015	Specifically, deacetylation of histone 3 at lysine 9 (H3K9), through the coordinated action of the NAD+-dependent protein deacetylase sirtuin-6 (SIRT6) and nuclear factor kappa B (NFkappaB), sequesters GR expression leading to disinhibition of CRF.	Lysine	44-50	sirtuin 6	Homo sapiens	145-150
29358331-2	2018	SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis.	Lysine	38-41	SET domain containing (lysine methyltransferase) 7	Mus musculus	84-88
29627904-1	2018	Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications.	Lysine	153-159	transglutaminase 1	Homo sapiens	10-26
29627904-1	2018	Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications.	Lysine	153-159	transglutaminase 1	Homo sapiens	28-33
29436543-8	2018	This is clear evidence that the tethered peptide Gly1-Gly2-Gly3-Lys1CONH2 hinders the complex binding, even though it contains groups that are able to assist it (e.g., the positively charged amino group of lysine, the peptidic backbone, the terminal amide).	Lysine	206-212	threonine aldolase 1, pseudogene	Homo sapiens	49-53
29627904-1	2018	Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications.	Lysine	161-164	transglutaminase 1	Homo sapiens	10-26
29627904-1	2018	Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications.	Lysine	161-164	transglutaminase 1	Homo sapiens	28-33
26426123-8	2015	Overexpression of NDPK-D along with SIRT1, or mutation in the acetylated lysine residues in NDPK-D, increases its nuclear accumulation.	Lysine	73-79	NME/NM23 nucleoside diphosphate kinase 4	Mus musculus	92-98
29447073-3	2018	Among the naturally occurring oligopeptides that were tested, Lys-Leu and Arg-Phe were Ptr2-specific substrates.	Lysine	62-65	Ptr2p	Saccharomyces cerevisiae S288C	87-91
26421062-5	2015	Transcriptional up-regulation correlated with decreased DNA methylation and enrichment of histone H3 lysine 4 trimethylation, an active chromatin mark, at the Slc17a6 promoter.	Lysine	101-107	solute carrier family 17 member 6	Homo sapiens	159-166
29730300-8	2018	APE1 lacking the first 34 amino acids at the N-terminus, unlike wild type enzyme, is unable to form cross-links with BS-AP DNAs that testifies to the involvement of disordered N-terminal extension, which is enriched in lysine residues, in the interaction with AP sites.	Lysine	219-225	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
29289525-1	2018	In 2016, two research groups independently identified microdeletions and pathogenic variants in the lysine-specific histone methyltransferase 2B gene, KMT2B in patients with early-onset progressive dystonia.	Lysine	100-106	lysine methyltransferase 2B	Homo sapiens	151-156
29915238-5	2018	Mass spectrometric analyses demonstrate that JMJD7 catalyzes Fe(II)- and 2OG-dependent hydroxylation of a highly conserved lysine residue in DRG1/2; amino-acid analyses reveal that JMJD7 catalyzes (3S)-lysyl hydroxylation.	Lysine	123-129	jumonji domain containing 7	Homo sapiens	45-50
29915238-5	2018	Mass spectrometric analyses demonstrate that JMJD7 catalyzes Fe(II)- and 2OG-dependent hydroxylation of a highly conserved lysine residue in DRG1/2; amino-acid analyses reveal that JMJD7 catalyzes (3S)-lysyl hydroxylation.	Lysine	123-129	jumonji domain containing 7	Homo sapiens	181-186
26310895-4	2015	As predicted based on SIRT6"s biological functions, the identified new SIRT6 inhibitors increase histone H3 lysine 9 acetylation, reduce TNF-alpha production and increase glucose uptake in cultured cells.	Lysine	108-114	sirtuin 6	Homo sapiens	22-27
26310895-4	2015	As predicted based on SIRT6"s biological functions, the identified new SIRT6 inhibitors increase histone H3 lysine 9 acetylation, reduce TNF-alpha production and increase glucose uptake in cultured cells.	Lysine	108-114	sirtuin 6	Homo sapiens	71-76
29242288-1	2018	Polycomb repressive complex 2 (PRC2) is a conserved chromatin-modifying enzyme that methylates histone H3 on lysine-27 (K27).	Lysine	109-115	Polycomb	Drosophila melanogaster	0-8
26130719-3	2015	Mechanistic investigation demonstrated that DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 lysine 27 trimethylation (H3K27me3) at the NEDD4L promoter.	Lysine	213-219	damage specific DNA binding protein 2	Homo sapiens	44-48
29743353-9	2018	Mutation analyses of all the lysine residues of MAVS further revealed that Lys325 of MAVS is catalyzed by TRIM21 for the K27-linked polyubiquitination.	Lysine	29-35	keratin 27	Homo sapiens	121-124
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	YEATS domain containing 4	Mus musculus	18-46
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	YEATS domain containing 4	Mus musculus	48-53
26221039-6	2015	Here, we report that MSH2 can be acetylated at Lys-73 near the N terminus.	Lysine	47-50	mutS homolog 2	Homo sapiens	21-25
29393359-4	2018	Further experiments confirmed that the conjugated site of Cx43 by SUMO1 was located in Lys-144 and Lys-237, both of which are highly conserved among species.	Lysine	87-90	gap junction protein alpha 1	Homo sapiens	58-62
26221039-8	2015	Although several Class I and II HDACs interact with MSH2, HDAC10 is the major enzyme that deacetylates MSH2 at Lys-73.	Lysine	111-114	mutS homolog 2	Homo sapiens	52-56
26221039-8	2015	Although several Class I and II HDACs interact with MSH2, HDAC10 is the major enzyme that deacetylates MSH2 at Lys-73.	Lysine	111-114	mutS homolog 2	Homo sapiens	103-107
26111449-3	2015	Together with another essential core component, SUZ12, EZH2 trimethylates histone H3 on lysine 27 (H3K27me3).	Lysine	88-94	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	48-53
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	K(lysine) acetyltransferase 5	Mus musculus	177-182
29393359-4	2018	Further experiments confirmed that the conjugated site of Cx43 by SUMO1 was located in Lys-144 and Lys-237, both of which are highly conserved among species.	Lysine	87-90	small ubiquitin like modifier 1	Homo sapiens	66-71
29393359-4	2018	Further experiments confirmed that the conjugated site of Cx43 by SUMO1 was located in Lys-144 and Lys-237, both of which are highly conserved among species.	Lysine	99-102	gap junction protein alpha 1	Homo sapiens	58-62
29394130-1	2018	MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines.	Lysine	132-139	PR/SET domain 9	Homo sapiens	59-84
29394130-1	2018	MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines.	Lysine	132-139	PR/SET domain 9	Homo sapiens	86-89
29393359-4	2018	Further experiments confirmed that the conjugated site of Cx43 by SUMO1 was located in Lys-144 and Lys-237, both of which are highly conserved among species.	Lysine	99-102	small ubiquitin like modifier 1	Homo sapiens	66-71
28992227-1	2018	Transglutaminase (TG) catalyses the formation of an isopeptide bond between glutamine and lysine residues and amine incorporation into specific glutamine residues.	Lysine	90-96	Transglutaminase	Drosophila melanogaster	0-16
29458143-8	2018	Mechanistic studies indicated that SUV39H2 can directly bind to the SLIT1 promoter, suppressing SLIT1 transcription by catalyzing histone H3 lysine 9 (H3K9) tri-methylation.	Lysine	141-147	SUV39H2 histone lysine methyltransferase	Homo sapiens	35-42
26212320-3	2015	During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM) essential for AMPK activation.	Lysine	52-58	small ubiquitin like modifier 1	Homo sapiens	25-30
26212320-3	2015	During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM) essential for AMPK activation.	Lysine	52-58	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	110-114
26212320-3	2015	During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM) essential for AMPK activation.	Lysine	52-58	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	164-168
28992227-1	2018	Transglutaminase (TG) catalyses the formation of an isopeptide bond between glutamine and lysine residues and amine incorporation into specific glutamine residues.	Lysine	90-96	Transglutaminase	Drosophila melanogaster	18-20
29457784-10	2018	Our study links the HIV/SIV infection-induced fatty acid enzyme ACSS2 to HIV latency and identifies histone lysine crotonylation as a novel epigenetic regulator for HIV transcription that can be targeted for HIV eradication.	Lysine	108-114	acyl-CoA synthetase short chain family member 2	Homo sapiens	64-69
25929155-12	2015	CONCLUSION: These data show that d-Ala(8) GLP-1(Lys(37) ) pentasaccharide exerts significant antidiabetic actions and has a projected pharmacokinetic/pharmacodynamic profile that merits further evaluation in humans for a possible once-weekly dosing regimen.	Lysine	48-51	glucagon like peptide 1 receptor	Homo sapiens	42-47
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Lysine	83-86	matrix metallopeptidase 2	Homo sapiens	149-154
29779246-6	2018	The specific binding of plg and tPA to lytic edges of partly degraded fibrin via newly generated C-terminal lysine residues, which amplifies fibrin digestion, is a central aspect of this pathophysiological mechanism.	Lysine	108-114	plasminogen	Homo sapiens	24-27
26061139-4	2015	Treatment of dairy cow mammary epithelial cells with amino acids (lysine or methionine) increased both cell growth and the expression of beta-casein (CSN2), WISP3, mTOR, and phospho-mTOR (p-mTOR).	Lysine	66-72	mechanistic target of rapamycin kinase	Bos taurus	164-168
26061139-4	2015	Treatment of dairy cow mammary epithelial cells with amino acids (lysine or methionine) increased both cell growth and the expression of beta-casein (CSN2), WISP3, mTOR, and phospho-mTOR (p-mTOR).	Lysine	66-72	mechanistic target of rapamycin kinase	Bos taurus	182-186
29482987-2	2018	Loss-of-function mutations in EED or SUZ12, which encode the core subunit of polycomb repressive complex 2 (PRC2), were reported in MPNSTs, and the mutations were shown to cause inactivation of PRC2, leading to loss of trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	251-257	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	37-42
26061139-4	2015	Treatment of dairy cow mammary epithelial cells with amino acids (lysine or methionine) increased both cell growth and the expression of beta-casein (CSN2), WISP3, mTOR, and phospho-mTOR (p-mTOR).	Lysine	66-72	mechanistic target of rapamycin kinase	Bos taurus	182-186
29773808-5	2018	Interestingly, the sole SUMO E2 enzyme, UBC9, was more SUMOylated during senescence on its Lys-49.	Lysine	91-94	ubiquitin conjugating enzyme E2 I	Homo sapiens	40-44
29773808-6	2018	Functional studies of a UBC9 mutant at Lys-49 showed a decreased association to PML-NBs and the loss of UBC9"s ability to delay senescence.	Lysine	39-42	ubiquitin conjugating enzyme E2 I	Homo sapiens	24-28
29345925-2	2018	In contrast to the ubiquitin (UB) and small ubiquitin-like modifier (SUMO) which are ligated to a massive segment of proteome, the UBL NEDD8 is highly selective for modifying a lysine residue on closely related cullin proteins (CULs).	Lysine	177-183	NEDD8 ubiquitin like modifier	Homo sapiens	135-140
29661849-1	2018	Drosophila Polycomb group (PcG) repressors confer epigenetically heritable silencing on key regulatory genes through histone H3 trimethylation on lysine 27 (H3K27me3).	Lysine	146-152	Polycomb	Drosophila melanogaster	11-25
29661849-1	2018	Drosophila Polycomb group (PcG) repressors confer epigenetically heritable silencing on key regulatory genes through histone H3 trimethylation on lysine 27 (H3K27me3).	Lysine	146-152	Polycomb	Drosophila melanogaster	27-30
25911675-3	2015	Here we show that the p300 acetyl-transferase physically interacts in vivo with DeltaNp63alpha and catalyzes its acetylation on lysine 193 (K193) inducing DeltaNp63alpha stabilization and activating specific transcriptional functions.	Lysine	128-134	E1A binding protein p300	Homo sapiens	22-26
26063505-4	2015	The increases of Asp, Lys, and Met in ak-hsdh2 were also observed in ak1-1, ak2-1, ak3-1, and ak-hsdh1-1.	Lysine	22-25	aspartate kinase 1	Arabidopsis thaliana	69-74
29345925-3	2018	In this study, the X-ray structure of a trapped E3-E2~NEDD8-target intermediate (RBX1-UBC1~NEDD8-CUL1-DCN1) is used to build computer models, and combined quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) and free energy (potential of mean force) simulations are performed to investigate the catalytic mechanism of the NEDD8 transfer from E2 to the lysine residue (K720) on the substrate in the complex.	Lysine	369-375	NEDD8 ubiquitin like modifier	Homo sapiens	54-59
29345925-3	2018	In this study, the X-ray structure of a trapped E3-E2~NEDD8-target intermediate (RBX1-UBC1~NEDD8-CUL1-DCN1) is used to build computer models, and combined quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) and free energy (potential of mean force) simulations are performed to investigate the catalytic mechanism of the NEDD8 transfer from E2 to the lysine residue (K720) on the substrate in the complex.	Lysine	369-375	cullin 1	Homo sapiens	97-101
29471853-13	2018	Mechanistically, HBXIP prevented chaperone-mediated autophagy (CMA)-dependent degradation of HOXB13 via enhancement of HOXB13 acetylation at the lysine 277 residue, causing the accumulation of HOXB13.	Lysine	145-151	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	17-22
26226295-8	2015	Localization of EHD3 to the tubular structures of the ERC depends on its SUMOylation on lysines 315 and 511.	Lysine	88-95	EH domain containing 3	Homo sapiens	16-20
29625008-6	2018	Presently, we describe the preparation of three Pol beta enzymes modified at position 72 with aminooxy or hydrazinyl analogues of lysine.	Lysine	130-136	DNA polymerase beta	Homo sapiens	48-56
29463306-6	2018	RESULTS: We show that HES1 is mono-ubiquitinated on a highly-conserved lysine residue that is located within a FA-like recognition motif.	Lysine	71-77	hes family bHLH transcription factor 1	Homo sapiens	22-26
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone lysine N-methyltransferase 2	Mus musculus	14-17
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone lysine N-methyltransferase 2	Mus musculus	33-38
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone lysine N-methyltransferase 2	Mus musculus	42-47
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone lysine N-methyltransferase 2	Mus musculus	58-61
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone methyltransferase 1	Mus musculus	90-95
29417943-4	2018	Two proteins, G9a (also known as EHMT2 or KMT1C) and GLP (G9a-like protein, also known as EHMT1 or KMT1D), which methylate lysine 9 of histone H3 (H3K9), could be promising anxiolytic targets.	Lysine	123-129	euchromatic histone methyltransferase 1	Mus musculus	99-104
26199140-3	2015	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.	Lysine	108-114	E1A binding protein p300	Homo sapiens	79-83
26073543-3	2015	Using affinity enrichment and label free quantitative proteomics, we characterized the SIRT5-regulated lysine malonylome in wild-type (WT) and Sirt5(-/-) mice.	Lysine	103-109	sirtuin 5	Mus musculus	87-92
26073543-9	2015	These data demonstrate that SIRT5 is a global regulator of lysine malonylation and provide a mechanism for regulation of energetic flux through glycolysis.	Lysine	59-65	sirtuin 5	Mus musculus	28-33
29769718-5	2018	Serine that is misactivated by AlaRS is captured by the lysine side chains of ANKRD16, which prevents the charging of serine adenylates to tRNAAla and precludes serine misincorporation in nascent peptides.	Lysine	56-62	ankyrin repeat domain 16	Mus musculus	78-85
29416009-6	2018	Further analysis revealed that GCN5 promoted osteogenic differentiation of BMSCs by increasing acetylation on histone 3 lysine 9 loci on the promoters of Wnt genes.	Lysine	120-126	wingless-type MMTV integration site family, member 1	Mus musculus	154-157
26183527-3	2015	Here, we demonstrate that the histone lysine methyltransferase SUV39H2 trimethylated LSD1 on lysine 322.	Lysine	38-44	SUV39H2 histone lysine methyltransferase	Homo sapiens	63-70
28879433-5	2018	Furthermore, we identify lysine (K) 119 as the main acetylation site in SMN.	Lysine	25-31	survival of motor neuron 1, telomeric	Homo sapiens	72-75
26183527-7	2015	Our results reveal the regulatory mechanism of LSD1 protein through its lysine methylation by SUV39H2 in human cancer cells.	Lysine	72-78	SUV39H2 histone lysine methyltransferase	Homo sapiens	94-101
29599268-5	2018	The binding of NF-YC antagonizes the association of CLF with chromatin and the CLF-dependent deposition of H3 lysine-27 trimethylation, thus relieving the repression of FT transcription and facilitating flowering under long-day conditions.	Lysine	110-116	SET domain-containing protein	Arabidopsis thaliana	79-82
29313530-3	2018	Here, we show that the enhancer-specific histone H3 lysine 4 monomethylation (H3K4me1) and the histone methyltransferases MLL3 and MLL4 (MLL3/4) play an active role in this process.	Lysine	52-58	lysine methyltransferase 2B	Homo sapiens	137-143
29430769-6	2018	Substitution of Lys-7 demonstrated that small and hydrophobic residues in close proximity to Gln-6 favor MTG-mediated modification and are likely to facilitate introduction of the substrate into the front vestibule of MTG.	Lysine	16-19	serine protease 3	Homo sapiens	105-108
29430769-6	2018	Substitution of Lys-7 demonstrated that small and hydrophobic residues in close proximity to Gln-6 favor MTG-mediated modification and are likely to facilitate introduction of the substrate into the front vestibule of MTG.	Lysine	16-19	serine protease 3	Homo sapiens	218-221
29507117-5	2018	SMU1, by acting as a substrate recognition module, binds to H2B and mediates monoubiquitylation at the lysine (K) residue K120 through CRL7SMU1 E3 ligase complex.	Lysine	103-109	SMU1 DNA replication regulator and spliceosomal factor	Homo sapiens	0-4
25995453-0	2015	SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet beta Cell.	Lysine	110-116	SET domain containing (lysine methyltransferase) 7	Mus musculus	0-6
25995453-1	2015	SET7/9 is an enzyme that methylates histone 3 at lysine 4 (H3K4) to maintain euchromatin architecture.	Lysine	49-55	SET domain containing (lysine methyltransferase) 7	Mus musculus	0-6
26023081-12	2015	Consistently, chromatin immunoprecipitation revealed that JARID1B occupies and reduces the histone 3 lysine 4 methylation levels at the HOXA5 promoter, demonstrating a direct function of JARID1B in endothelial HOXA5 gene regulation.	Lysine	101-107	lysine demethylase 5B	Homo sapiens	58-65
29247011-1	2018	The trimethylation of histone H3 at lysine 27 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2) is essential for the repression of Polycomb target genes.	Lysine	36-42	Polycomb	Drosophila melanogaster	60-68
26023081-12	2015	Consistently, chromatin immunoprecipitation revealed that JARID1B occupies and reduces the histone 3 lysine 4 methylation levels at the HOXA5 promoter, demonstrating a direct function of JARID1B in endothelial HOXA5 gene regulation.	Lysine	101-107	lysine demethylase 5B	Homo sapiens	187-194
29247011-1	2018	The trimethylation of histone H3 at lysine 27 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2) is essential for the repression of Polycomb target genes.	Lysine	36-42	Polycomb	Drosophila melanogaster	132-140
28764817-5	2018	The degree of trimethylation of histone H3 lysine 27 (H3K27me3) at TXNIP promoter was examined semi-quantitatively by chromatin immunoprecipitation polymerase chain reaction.	Lysine	43-49	thioredoxin interacting protein	Bos taurus	67-72
25939886-7	2015	We next established that LRRK2 is ubiquitinated through at least Lys(48) and Lys(63) ubiquitin linkages in response to inhibition.	Lysine	65-68	leucine-rich repeat kinase 2	Mus musculus	25-30
25939886-7	2015	We next established that LRRK2 is ubiquitinated through at least Lys(48) and Lys(63) ubiquitin linkages in response to inhibition.	Lysine	77-80	leucine-rich repeat kinase 2	Mus musculus	25-30
29713182-17	2018	SUMO1 modification of PKM2 at Lys-336 site increased glycolysis and promoted its cofactor functions.	Lysine	30-33	small ubiquitin like modifier 1	Homo sapiens	0-5
29176272-8	2018	This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45).	Lysine	78-81	aldehyde dehydrogenase 2 family member	Homo sapiens	68-73
29232016-10	2018	Additionally, we noted that Histone H3 lysine 36 dimethylation and linker Histone H1 abundance is reduced in H3.3-deficient embryos, which was similar to effects following knockdown of CHD1 (Chromodomain helicase DNA-binding protein 1).	Lysine	39-45	histocompatibility 33	Mus musculus	109-113
29670509-3	2018	KDM5C encodes a histone demethylase for di- and tri-methylated histone H3 lysine 4 (H3K4me2/3), which are enriched in transcriptionally engaged promoter regions.	Lysine	74-80	lysine demethylase 5C	Homo sapiens	0-5
29339121-6	2018	HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2.	Lysine	190-196	heat shock transcription factor 1	Homo sapiens	0-4
29339121-6	2018	HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2.	Lysine	190-196	MORC family CW-type zinc finger 2	Homo sapiens	12-17
25109415-15	2015	Patients with at least one missense mutation in SLC3A1 had significantly lower levels of lysine, arginine, and ornithine but not cystine than patients with all other combinations of mutations.	Lysine	89-95	solute carrier family 3 member 1	Homo sapiens	48-54
29274508-0	2018	A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40.	Lysine	45-51	chitinase 3 like 1	Homo sapiens	80-86
25891951-3	2015	We show that NACC1 is SUMOylated on a phylogenetically conserved lysine (K167) out of three consensus SUMOylation motif sites.	Lysine	65-71	nucleus accumbens associated 1	Homo sapiens	13-18
29548294-5	2018	RESULTS: A physics-based framework is proposed that predicts the effect of charge-altering PTMs in the histone core, quantitatively for several types of lysine charge-neutralizing PTMs including acetylation, and qualitatively for all phosphorylations, on the nucleosome stability and subsequent changes in DNA accessibility, making a connection to resulting biological phenotypes.	Lysine	153-159	parathymosin	Homo sapiens	91-95
29548294-5	2018	RESULTS: A physics-based framework is proposed that predicts the effect of charge-altering PTMs in the histone core, quantitatively for several types of lysine charge-neutralizing PTMs including acetylation, and qualitatively for all phosphorylations, on the nucleosome stability and subsequent changes in DNA accessibility, making a connection to resulting biological phenotypes.	Lysine	153-159	parathymosin	Homo sapiens	180-184
29274508-3	2018	YKL-40 harbors a consensus heparin-binding motif that consists of positively charged arginine (R) and lysine (K) (RRDK; residues 144-147); but they don"t bind to heparin.	Lysine	102-108	chitinase 3 like 1	Homo sapiens	0-6
28988317-6	2018	Neutralization of cationic Lys (K330A) also eliminated the acidic pHi sensitivity of ITREK-2,i-o.	Lysine	27-30	glucose-6-phosphate isomerase	Homo sapiens	66-69
29545540-4	2018	Only cytoplasmic ubiquitylation targets Ascl1 for destruction, which occurs by conjugation of ubiquitin to lysines in the basic helix-loop-helix domain of Ascl1 and requires the E3 ligase Huwe1.	Lysine	107-114	achaete-scute family bHLH transcription factor 1	Homo sapiens	40-45
29545540-4	2018	Only cytoplasmic ubiquitylation targets Ascl1 for destruction, which occurs by conjugation of ubiquitin to lysines in the basic helix-loop-helix domain of Ascl1 and requires the E3 ligase Huwe1.	Lysine	107-114	achaete-scute family bHLH transcription factor 1	Homo sapiens	155-160
29545540-5	2018	In contrast, chromatin-bound Ascl1 associated with short ubiquitin-chains, which can occur on lysines within the N-terminal region or the bHLH domain and is not mediated by Huwe1, is not targeted for ubiquitin-mediated destruction.	Lysine	94-101	achaete-scute family bHLH transcription factor 1	Homo sapiens	29-34
26092847-2	2015	CHD1, which recognizes trimethylated histone H3 lysine 4, has been implicated in transcriptional activation in organisms ranging from yeast to humans.	Lysine	48-54	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	0-4
26033389-0	2015	Acetylation of lysine 9 on histone H3 is associated with increased pro-inflammatory cytokine release in a cigarette smoke-induced rat model through HDAC1 depression.	Lysine	15-21	histone deacetylase 1	Rattus norvegicus	148-153
29520069-4	2018	The HDAC9-MALAT1-BRG1 complex binds chromatin and represses contractile protein gene expression in association with gain of histone H3-lysine 27 trimethylation modifications.	Lysine	135-141	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	17-21
29434596-9	2018	Lysine-to-alanine mutations at the PI-binding residues abolished TIRAP"s affinity for PIP2; however, K34, K35, and R36 consistently interacted with PIP2 headgroups through hydrogen bond (H-bond) and electrostatic interactions.	Lysine	0-6	TIR domain containing adaptor protein	Homo sapiens	65-70
29358211-5	2018	We show that the K63 polyubiquitination at lysine 162 and 181 of RhoB targets the protein to lysosomes.	Lysine	43-49	ras homolog family member B	Homo sapiens	65-69
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Lysine	37-40	aldehyde dehydrogenase 2 family member	Homo sapiens	30-36
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Lysine	37-40	aldehyde dehydrogenase 2 family member	Homo sapiens	93-99
29180469-3	2018	SIRT5 interaction directly mediated desuccinylation of lysine 280 on SHMT2, which was crucial for activating its enzymatic activity.	Lysine	55-61	sirtuin 5	Homo sapiens	0-5
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Lysine	236-239	calcium/calmodulin dependent protein kinase ID	Homo sapiens	105-115
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Lysine	236-239	calcium/calmodulin dependent protein kinase ID	Homo sapiens	216-226
29447067-0	2018	Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation.	Lysine	70-76	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	52-57
29447067-2	2018	Lysine methylations are also found on many non-histone proteins, and one prominent example is eukaryotic elongation factor 1 alpha (eEF1A).	Lysine	0-6	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	132-137
29447067-4	2018	The functional significance of the extensive lysine methylations on eEF1A, as well as the identity of the responsible lysine methyltransferases (KMTs), have until recently remained largely elusive.	Lysine	45-51	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	68-73
29447067-5	2018	However, recent discoveries and characterizations of human eEF1A-specific KMTs indicate that lysine methylation of eEF1A can be dynamic and inducible, and modulates mRNA translation in a codon-specific fashion.	Lysine	93-99	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	59-64
29180469-4	2018	Conversely, hypersuccinylation of SHMT2 at lysine 280 was sufficient to inhibit its enzymatic activity and downregulate tumor cell growth in vitro and in vivo Notably, SIRT5 inactivation led to SHMT2 enzymatic downregulation and to abrogated cell growth under metabolic stress.	Lysine	43-49	sirtuin 5	Homo sapiens	168-173
29447067-5	2018	However, recent discoveries and characterizations of human eEF1A-specific KMTs indicate that lysine methylation of eEF1A can be dynamic and inducible, and modulates mRNA translation in a codon-specific fashion.	Lysine	93-99	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	115-120
25918018-0	2015	A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.	Lysine	2-8	NEDD8 ubiquitin like modifier	Homo sapiens	33-38
25918018-1	2015	Neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8) is a ubiquitin-like modifier, which forms covalent conjugates on lysines of its substrates.	Lysine	138-145	NEDD8 ubiquitin like modifier	Homo sapiens	0-64
25918018-1	2015	Neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8) is a ubiquitin-like modifier, which forms covalent conjugates on lysines of its substrates.	Lysine	138-145	NEDD8 ubiquitin like modifier	Homo sapiens	66-71
29447067-6	2018	Here, we give a general overview of eEF1A lysine methylation and discuss its possible functional and regulatory significance, with particular emphasis on newly discovered human KMTs.	Lysine	42-48	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	36-41
29233695-2	2018	meso-Diaminopimelic acid decarboxylase (DAPDC) catalyzes the final step in the de novol-lysine biosynthetic pathway by converting meso-diaminopimelic acid (meso-DAP) into l-lysine by decarboxylation reaction.	Lysine	88-94	death associated protein	Homo sapiens	40-43
25918018-10	2015	This work sheds new light on the roles of NEDD8 lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.	Lysine	48-55	NEDD8 ubiquitin like modifier	Homo sapiens	42-47
29233695-2	2018	meso-Diaminopimelic acid decarboxylase (DAPDC) catalyzes the final step in the de novol-lysine biosynthetic pathway by converting meso-diaminopimelic acid (meso-DAP) into l-lysine by decarboxylation reaction.	Lysine	86-94	death associated protein	Homo sapiens	40-43
26060329-5	2015	We hypothesized that constitutive SUMO2 conjugation and deconjugation occurred basally and that arsenic trioxide treatment caused the exchange of SUMO2 for SUMO1 on a fraction of Lys(65) in PML.	Lysine	179-182	small ubiquitin like modifier 1	Homo sapiens	156-161
29233695-5	2018	We also determined the CgDAPDC structure in complex with both pyridoxal 5"-phosphate (PLP) and the l-lysine product and revealed that the protein has an optimal substrate binding pocket to accommodate meso-DAP as a substrate.	Lysine	99-107	death associated protein	Homo sapiens	25-28
29321206-5	2018	Overexpression of MOF in human embryonic kidney 293T cells induced significantly increased propionylation in multiple histone and non-histone proteins, which shows that the function of MOF goes far beyond its canonical histone H4 lysine 16 acetylation.	Lysine	230-236	lysine acetyltransferase 8	Homo sapiens	18-21
29111742-0	2018	Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.	Lysine	29-35	myelin basic protein	Mus musculus	51-71
26182377-5	2015	The PTS1-receptor is either polyubiquitinated via peptide bonds at two certain lysines and results in proteasomal degradation or monoubiquitinated via a thioester-bond at a conserved cysteine, which enables the recycling of Pex5p and further rounds of matrix protein import.	Lysine	79-86	peroxisomal biogenesis factor 5	Homo sapiens	4-17
29111742-2	2018	Here we identify lysine acetylation as another neutralizing PTM to MBP that may be involved in myelin damage.	Lysine	17-23	myelin basic protein	Mus musculus	67-70
25743599-5	2015	In the case of human polymerase eta, ubiquitination at four lysine residues in its C-terminus appears to regulate its ability to interact with PCNA and modulate TLS.	Lysine	60-66	endothelin receptor type A	Homo sapiens	32-35
29557214-8	2018	SIRT6 can enhance the reprogramming efficiency of iPSCs from aged skin fibroblasts through miR-766 and increase the expression levels of the reprogramming genes including Sox2, Oct4, and Nanog through acetylation of histone H3 lysine 56.	Lysine	227-233	sirtuin 6	Homo sapiens	0-5
25743599-7	2015	In this review, we will summarize the known lysine modifications of several key proteins involved in TLS; PCNA and Y-family polymerases eta, iota, kappa and Rev1 and we will discuss the potential regulatory effects of such modification in controlling TLS in vivo.	Lysine	44-50	endothelin receptor type A	Homo sapiens	136-139
29111742-3	2018	We quantify changes in lysine and arginine PTMs on MBP derived from mice induced with an experimental autoimmune encephalomyelitis (EAE) model of MS using liquid chromatography tandem mass spectrometry.	Lysine	23-29	myelin basic protein	Mus musculus	51-54
29111742-5	2018	We found that lysine acetylation increased by 2-fold on MBP during peak NDS post-EAE induction.	Lysine	14-20	myelin basic protein	Mus musculus	56-59
29276005-8	2018	Additionally, we describe a recessive histone lysine-methylation defect caused by homozygous or compound heterozygous KDM5B variants and resulting in a recognizable syndrome with developmental delay, facial dysmorphism, and camptodactyly.	Lysine	46-52	lysine demethylase 5B	Homo sapiens	118-123
25103872-1	2015	The lysyl oxidase (LOX) family of proteins (LOX and LOXL1-LOXL4) oxidize amino groups located in the epsilon-position in lysines to generate an aldehyde group.	Lysine	121-128	lysyl oxidase like 1	Homo sapiens	52-57
25103872-1	2015	The lysyl oxidase (LOX) family of proteins (LOX and LOXL1-LOXL4) oxidize amino groups located in the epsilon-position in lysines to generate an aldehyde group.	Lysine	121-128	lysyl oxidase like 4	Homo sapiens	58-63
25918939-1	2015	In yeast Saccharomyces cerevisiae, ~3% of the lysine transfer RNA acceptor 1 (tRK1) pool is imported into mitochondria while the second isoacceptor, tRK2, fully remains in the cytosol.	Lysine	46-52	Trk1p	Saccharomyces cerevisiae S288C	78-82
29288497-3	2018	Most ARS genes in these cellular compartments are distinct, but two genes are common, encoding aminoacyl-tRNA synthetases of glycine (GARS) and lysine (KARS) in both mitochondria and the cytosol.	Lysine	144-150	RIEG2	Homo sapiens	5-8
29035139-1	2018	Lysine-specific demethylase 1B (KDM1B) which plays a crucial role in regulating methylation status at lysine 4 of histone 3 is important for male fertility.	Lysine	102-108	lysine demethylase 1B	Sus scrofa	32-37
29462142-5	2018	Double mutants of Rnf8 and Scml2 revealed that RNF8-dependent monoubiquitination of histone H2A at Lysine 119 (H2AK119ub) is deubiquitinated by SCML2, demonstrating interplay between RNF8 and SCML2 in ubiquitin regulation.	Lysine	99-105	Scm polycomb group protein like 2	Homo sapiens	27-32
29462142-5	2018	Double mutants of Rnf8 and Scml2 revealed that RNF8-dependent monoubiquitination of histone H2A at Lysine 119 (H2AK119ub) is deubiquitinated by SCML2, demonstrating interplay between RNF8 and SCML2 in ubiquitin regulation.	Lysine	99-105	Scm polycomb group protein like 2	Homo sapiens	144-149
25713082-0	2015	Transcriptional activity of the islet beta cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.	Lysine	76-82	pancreatic and duodenal homeobox 1	Mus musculus	55-59
25713082-0	2015	Transcriptional activity of the islet beta cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.	Lysine	76-82	SET domain containing (lysine methyltransferase) 7	Mus musculus	130-136
29634390-6	2018	Then we demonstrate that SETD7 methylates ATG16L1 at lysine 151 while KDM1A/LSD1 (lysine demethylase 1A) removes this methyl mark.	Lysine	53-59	autophagy related 16 like 1	Homo sapiens	42-49
25713082-4	2015	Using mass spectrometry and mutational analysis of purified proteins, we found that Set7/9 methylates the N-terminal residues Lys-123 and Lys-131 of Pdx1.	Lysine	126-129	SET domain containing (lysine methyltransferase) 7	Mus musculus	84-90
25713082-4	2015	Using mass spectrometry and mutational analysis of purified proteins, we found that Set7/9 methylates the N-terminal residues Lys-123 and Lys-131 of Pdx1.	Lysine	126-129	pancreatic and duodenal homeobox 1	Mus musculus	149-153
29452636-6	2018	Finally, we identify NOD2 signaling and XIAP-dependent ubiquitination sites on RIP2 and show that mutating these lysine residues adversely affects NOD2 pathway signaling.	Lysine	113-119	nucleotide binding oligomerization domain containing 2	Homo sapiens	21-25
29452636-6	2018	Finally, we identify NOD2 signaling and XIAP-dependent ubiquitination sites on RIP2 and show that mutating these lysine residues adversely affects NOD2 pathway signaling.	Lysine	113-119	nucleotide binding oligomerization domain containing 2	Homo sapiens	147-151
29634390-7	2018	Furthermore, we validate that this methylation at lysine 151 impairs the binding of ATG16L1 to the ATG12-ATG5 conjugate, leading to inhibition of autophagy and increased apoptosis in H/R-treated cardiomyocytes.	Lysine	50-56	autophagy related 16 like 1	Homo sapiens	84-91
29447173-1	2018	SETD2 (SET domain containing protein 2) acts as a histone H3 lysine 36 (H3K36)-specific methyltransferase and may play important roles in active gene transcription in human cells.	Lysine	61-67	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
25697176-0	2015	Replisome function during replicative stress is modulated by histone h3 lysine 56 acetylation through Ctf4.	Lysine	72-78	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	102-106
25697176-4	2015	Rather, our genetic analyses suggest that in the presence of replicative stress H3 lysine 56 acetylation uncouples the Cdc45-Mcm2-7-GINS DNA helicase complex and DNA polymerases through the replisome component Ctf4.	Lysine	83-89	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	210-214
29634390-9	2018	Additionally, methylation at lysine 151 inhibits phosphorylation of ATG16L1 at S139 by CSNK2 which was previously shown to be critical for autophagy maintenance, and vice versa.	Lysine	29-35	autophagy related 16 like 1	Homo sapiens	68-75
25697176-5	2015	In addition, we discovered that the N-terminal domain of Ctf4, necessary for the interaction of Ctf4 with Mms22, an adaptor protein of the Rtt101-Mms1 E3 ubiquitin ligase, is required for the function of the H3 lysine 56 acetylation pathway, suggesting that replicative stress promotes the interaction between Ctf4 and Mms22.	Lysine	211-217	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	57-61
29402932-3	2018	As a key component of polycomb repressive complex 1 (PRC1), BMI1 exerts its oncogenic functions by enhancing the enzymatic activities of RING1B to ubiquitinate histone H2A at lysine 119 and repress gene transcription.	Lysine	175-181	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	60-64
29954236-4	2018	Cells deficient in ASF1A/B or CAF-1 exhibit reduced histone H4 lysine 16 acetylation (H4K16ac), a histone mark known to promote ATM activation.	Lysine	63-69	chromatin assembly factor 1 subunit A	Homo sapiens	30-35
29402932-3	2018	As a key component of polycomb repressive complex 1 (PRC1), BMI1 exerts its oncogenic functions by enhancing the enzymatic activities of RING1B to ubiquitinate histone H2A at lysine 119 and repress gene transcription.	Lysine	175-181	ring finger protein 2	Homo sapiens	137-143
29634317-2	2018	Nuclear receptor binding SET domain protein 3 (NSD3) is a member of the lysine methyltransferase family.	Lysine	72-78	nuclear receptor binding SET domain protein 3	Homo sapiens	0-45
29634317-2	2018	Nuclear receptor binding SET domain protein 3 (NSD3) is a member of the lysine methyltransferase family.	Lysine	72-78	nuclear receptor binding SET domain protein 3	Homo sapiens	47-51
25697176-5	2015	In addition, we discovered that the N-terminal domain of Ctf4, necessary for the interaction of Ctf4 with Mms22, an adaptor protein of the Rtt101-Mms1 E3 ubiquitin ligase, is required for the function of the H3 lysine 56 acetylation pathway, suggesting that replicative stress promotes the interaction between Ctf4 and Mms22.	Lysine	211-217	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	96-100
25697176-5	2015	In addition, we discovered that the N-terminal domain of Ctf4, necessary for the interaction of Ctf4 with Mms22, an adaptor protein of the Rtt101-Mms1 E3 ubiquitin ligase, is required for the function of the H3 lysine 56 acetylation pathway, suggesting that replicative stress promotes the interaction between Ctf4 and Mms22.	Lysine	211-217	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	96-100
25697176-6	2015	Taken together, our results indicate that Ctf4 is an essential member of the H3 lysine 56 acetylation pathway and provide novel mechanistic insights into understanding the role of H3 lysine 56 acetylation in maintaining genome stability upon replication stress.	Lysine	80-86	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	42-46
25697176-6	2015	Taken together, our results indicate that Ctf4 is an essential member of the H3 lysine 56 acetylation pathway and provide novel mechanistic insights into understanding the role of H3 lysine 56 acetylation in maintaining genome stability upon replication stress.	Lysine	183-189	chromatin-binding protein CTF4	Saccharomyces cerevisiae S288C	42-46
28988317-11	2018	The results show concerted roles of the oppositely charged Lys and Glu in pCt for the ATP-dependent low basal activity and pHi sensitivity.	Lysine	59-62	glucose-6-phosphate isomerase	Homo sapiens	123-126
29568171-2	2018	YKL-40 is derived from tyrosine (Y), lysine (K), and leucine (L) with a molecular weight of 40 kDa.	Lysine	37-43	chitinase 3 like 1	Homo sapiens	0-6
25636406-7	2015	Furthermore, these differences hinge on proline 8, which is conserved in CCL3 and CCL4 but is replaced by lysine in human CCL18.	Lysine	106-112	C-C motif chemokine ligand 18	Homo sapiens	122-127
29962430-7	2018	The mRNA expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-alpha and carnitine palmitoyltransferase 1a, which regulate beta-oxidation, were increased in the livers of SAMP8 mice fed the Lys-rich diet.	Lysine	220-223	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	30-98
25806939-0	2015	Endogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi.	Lysine	74-80	plasminogen	Homo sapiens	23-30
29311602-3	2018	Recent studies have shown that RING1 domains bind E2~Ub conjugates in an open conformation to supress ubiquitin transfer onto lysine residues and promote formation of the E3 thioester intermediate.	Lysine	126-132	ring finger protein 1	Homo sapiens	31-36
29105190-4	2018	Here, we demonstrate that a lysine (K100) on the surface of CRP has a dual function: to promote CRP activity at Class II promoters, and to ensure proper CRP steady state levels.	Lysine	28-34	complement C1q like 3	Homo sapiens	36-40
29143563-0	2018	Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.	Lysine	110-116	CREB regulated transcription coactivator 2	Mus musculus	41-47
29143563-5	2018	Here, we identified histone H3 lysine 56 acetylation (H3K56Ac) is regulated by mTORC2 and show that global H3K56Ac levels were downregulated on mTORC2 knockdown but not on mTORC1 knockdown.	Lysine	31-37	CREB regulated transcription coactivator 2	Mus musculus	79-85
29143563-5	2018	Here, we identified histone H3 lysine 56 acetylation (H3K56Ac) is regulated by mTORC2 and show that global H3K56Ac levels were downregulated on mTORC2 knockdown but not on mTORC1 knockdown.	Lysine	31-37	CREB regulated transcription coactivator 2	Mus musculus	144-150
29143563-5	2018	Here, we identified histone H3 lysine 56 acetylation (H3K56Ac) is regulated by mTORC2 and show that global H3K56Ac levels were downregulated on mTORC2 knockdown but not on mTORC1 knockdown.	Lysine	31-37	CREB regulated transcription coactivator 1	Mus musculus	172-178
25880753-5	2015	Furthermore, we show for the first time that TRIM5alpha is SUMOylated both in vitro and in cellulo and that Lysine 10 is the main SUMOylation site.	Lysine	108-114	tripartite motif containing 5	Homo sapiens	45-55
29105190-5	2018	Both functions require the lysine"s positive charge; intriguingly, the positive charge of K100 can be neutralized by acetylation using the central metabolite acetyl phosphate as the acetyl donor.	Lysine	27-33	complement C1q like 3	Homo sapiens	90-94
29059503-7	2017	In a second approach, the P2 arginine was replaced by lysine; compared to MI-1148, this furin inhibitor has slightly decreased potency, but exhibits similar antiviral activity against West Nile and Dengue virus in cell culture and decreased toxicity in mice.	Lysine	54-60	furin (paired basic amino acid cleaving enzyme)	Mus musculus	88-93
26020882-9	2015	Increasing the SID Trp to Lys ratio increased the protein abundance of the muscular AA transporter of sodium-coupled neutral amino acid transporter 2 (SNAT2) in the longissimus dorsi muscle (linear and quadratic effect, &lt; 0.05).	Lysine	26-29	LOC100738862	Sus scrofa	102-149
26020882-9	2015	Increasing the SID Trp to Lys ratio increased the protein abundance of the muscular AA transporter of sodium-coupled neutral amino acid transporter 2 (SNAT2) in the longissimus dorsi muscle (linear and quadratic effect, &lt; 0.05).	Lysine	26-29	LOC100738862	Sus scrofa	151-156
29160738-10	2018	In non-replicated DNA, saturating levels of the 53BP1 binding site, di-methylated lysine 20 of histone 4 (H4K20me2), lead to robust 53BP1-RIF1-MAD2L2 recruitment at DSBs, with consequent exclusion of BRCA1.	Lysine	82-88	replication timing regulatory factor 1	Homo sapiens	138-142
29101251-0	2017	The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.	Lysine	73-79	nuclear receptor binding SET domain protein 3	Homo sapiens	22-26
27625029-4	2018	This resulted in a glutamic acid to lysine substitution in helical domain 2 of the nucleotide binding and oligomerization (NACHT) region, possibly reducing efficiency of auto-inhibition in NOD2 signaling.	Lysine	36-42	nucleotide binding oligomerization domain containing 2	Homo sapiens	189-193
25673844-5	2015	We show by crystallographic and other analyses that the phosphorylated Thr84 residue binds to a pocket formed by three conserved Lys residues (Lys314, Lys326, and Lys328) on the surface of the synaptotagmin-1 C2B domain.	Lysine	129-132	synaptotagmin 1	Homo sapiens	193-208
29101251-0	2017	The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.	Lysine	73-79	interferon regulatory factor 3	Homo sapiens	95-99
30375897-14	2018	By Sanger sequencing, we identified a transition mutation in the alpha1 gene Hb Shantou [alpha127(H10)Lys &gt; Glu; HBA1: c.382 A &gt; G].	Lysine	102-105	hemoglobin subunit alpha 1	Homo sapiens	116-120
29354728-1	2017	Background: Tranexamic acid is a synthetic lysine-analogue antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, it is a well-documented blood sparing agent.	Lysine	43-49	plasminogen	Homo sapiens	122-129
29274231-5	2017	In addition to zinc finger domains in CPSF30, we identify using quantitative RNA-binding assays an N-terminal lysine/arginine-rich motif in WDR33 as a critical determinant of specific AAUAAA motif recognition.	Lysine	110-116	WD repeat domain 33	Homo sapiens	140-145
29435148-5	2018	We designed a 15 amino acids peptide based on the sequence of the RelA protein (residues 302-316), containing the lysine that is methylated by SETD6.	Lysine	114-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	66-70
29311918-2	2017	Gly-His-Lys (GHK) is a tripeptide involved in the processes of tissue regeneration and wound healing and has significant inhibitory effects on transforming growth factor (TGF)-beta1 secretion.	Lysine	8-11	transforming growth factor, beta 1	Mus musculus	143-181
28846111-6	2017	Mutation of both lysine residues to arginine (R) abolished t-HO-1-enhanced tumor cell growth, migration and invasion.	Lysine	17-23	THO complex 1	Homo sapiens	59-65
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	homeobox A9	Homo sapiens	309-314
28974580-10	2017	Finally, the SUMO acceptor lysine was functionally required for ErbB4 ICD-mediated inhibition of mammary epithelial cell differentiation in a three-dimensional cell culture model.	Lysine	27-33	erb-b2 receptor tyrosine kinase 4	Homo sapiens	64-69
28663172-6	2017	Recombinant METTL21B was shown in vitro to catalyze methylation on lysine 165 in eEF1A1 and eEF1A2, confirming it as the methyltransferase responsible for this methylation site.	Lysine	67-73	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	81-87
29029378-0	2017	Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner.	Lysine	29-35	GPN-loop GTPase 3	Homo sapiens	0-4
29029378-2	2017	Global studies have identified by mass spectrometry that human Gpn3 is ubiquitinated on lysines 189 and 216.	Lysine	88-95	GPN-loop GTPase 3	Homo sapiens	63-67
29029378-8	2017	In conclusion, Gpn1-inhibitable, nuclear polyubiquitination on lysine 216 regulates the half-life of Gpn3 by tagging it for proteasomal degradation.	Lysine	63-69	GPN-loop GTPase 3	Homo sapiens	101-105
27815838-3	2017	This purpose of the study focused on exploring whether epigenetic modifications marker histone H3 lysine 27 trimethylation (H3K27me3)-regulated DPP4 and IL6 expression further affected seizures development.	Lysine	98-104	dipeptidylpeptidase 4	Rattus norvegicus	144-148
29123501-7	2017	Many of the GnRH receptor mutations associated with congenital hypogonadotropic hypogonadism, including the Glu2.53(90) Lys mutation, involve amino acids that constitute the conserved network.	Lysine	120-123	gonadotropin releasing hormone receptor	Homo sapiens	12-25
29045477-2	2017	Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-beta1-induced EMT (epithelial-mesenchymal transition).	Lysine	96-102	transforming growth factor, beta 1	Mus musculus	134-143
28883095-7	2017	Strikingly, the acetylation/deacetylation status of the lysine residues within the motif determines Fbxl17 binding.	Lysine	56-62	F-box and leucine rich repeat protein 17	Homo sapiens	100-106
28899943-5	2017	Results presented here indicate that Isw1 is not only ubiquitylated but also strongly SUMOylated on multiple lysine residues by the redundant Siz1/Siz2 SUMO E3 ligases.	Lysine	109-115	SUMO ligase NFI1	Saccharomyces cerevisiae S288C	147-151
28923203-6	2017	Our further studies show that down-regulation of miR-34a is caused by Enhancer of zeste homolog 2 (EZH2)-mediated H3 lysine 27 trimethylation as well as DNA methylation.	Lysine	117-123	microRNA 34a	Homo sapiens	49-56
29082591-7	2017	Chromatin immunoprecipitation assays showed an increased presence of H3K27me3, trimethylation of lysine 27 on histone H3, on the promoter region of bone morphogenetic protein-2.	Lysine	97-103	bone morphogenetic protein 2	Homo sapiens	148-176
28508686-3	2017	Recurrent inactivation of EED or SUZ12 in a majority of MPNSTs results in a complete loss of trimethylated histone H3 at lysine 27 (H3K27me3) immunoreactivity, making it a highly specific biomarker of MPNSTs.	Lysine	121-127	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	33-38
28382690-8	2017	Acetylated lysine 9 on histone H3 (AcH3K9) levels of cTnI"s promoter were increased through EGCG treatment.	Lysine	11-17	troponin I, cardiac 3	Mus musculus	53-57
28771755-8	2017	Furthermore, PKL affects the level of trimethylation of histone H3 Lys 27 associated with INDOLE-3-ACETIC ACID INDUCIBLE 19 (IAA19) and IAA29 and regulates their expression.	Lysine	67-70	indole-3-acetic acid inducible 29	Arabidopsis thaliana	136-141
28876923-3	2017	A lysine derivative of Sph, SphK, was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of class B G protein-coupled receptors (GPCRs) in mammalian cells with the incorporation efficiency dependent on the location.	Lysine	2-8	glucagon receptor	Homo sapiens	114-118
28876923-3	2017	A lysine derivative of Sph, SphK, was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of class B G protein-coupled receptors (GPCRs) in mammalian cells with the incorporation efficiency dependent on the location.	Lysine	2-8	glucagon like peptide 1 receptor	Homo sapiens	123-129
28778944-6	2017	RESULTS: We found that G9a is required for cardiomyocyte homeostasis in the adult heart by mediating the repression of key genes regulating cardiomyocyte function via dimethylation of H3 lysine 9 and interaction with enhancer of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene expression by forming a complex with this transcription factor.	Lysine	187-193	euchromatic histone lysine N-methyltransferase 2	Mus musculus	23-26
28916765-2	2017	In the widely accepted catalytic mechanism of the aminotransferase family, the lysine binding to PLP acts as a catalyst in the stepwise 1,3-proton transfer, interconverting the external aldimine to ketimine.	Lysine	79-85	pyridoxal phosphatase	Homo sapiens	97-100
28910420-4	2017	Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc.	Lysine	18-25	prion protein	Rattus norvegicus	53-57
28910420-4	2017	Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc.	Lysine	18-25	prion protein	Mus musculus	218-223
28910420-4	2017	Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc.	Lysine	18-25	prion protein	Mus musculus	255-260
28910420-4	2017	Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc.	Lysine	18-24	prion protein	Rattus norvegicus	53-57
28878246-4	2017	NR2E3 loss promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR expression.	Lysine	80-86	nuclear receptor subfamily 2, group E, member 3	Mus musculus	0-5
28734980-7	2017	Mechanistically, PHF8 regulates hypoxia inducible genes mainly through sustaining the level of trimethylated histone 3 lysine 4 (H3K4me3), an active mark in transcriptional regulation.	Lysine	119-125	PHD finger protein 8	Homo sapiens	17-21
28386724-2	2017	Central to this process is the Set2/SETD2 methyltransferase that mediates co-transcriptional methylation to histone H3 at lysine 36 (H3K36me).	Lysine	122-128	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	31-35
28386724-2	2017	Central to this process is the Set2/SETD2 methyltransferase that mediates co-transcriptional methylation to histone H3 at lysine 36 (H3K36me).	Lysine	122-128	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	36-41
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Lysine	150-156	solute carrier family 7 member 2	Homo sapiens	0-33
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Lysine	150-156	solute carrier family 7 member 2	Homo sapiens	35-41
28627122-11	2017	These results suggest that biotinylated peptides, especially BP21, can specifically and markedly inhibit anaphylactic reactions in vivo and that this involves direct interaction of its Tyr-Lys-Asp-Gly region with PAF.	Lysine	189-192	Blood pressure QTL 21	Rattus norvegicus	61-65
28346821-1	2017	Human p300 is a polyhedric transcriptional coactivator that plays a crucial role in acetylating histones on specific lysine residues.	Lysine	117-123	E1A binding protein p300	Homo sapiens	6-10
28848693-4	2017	Mass spectrometry of a variant of Deg1-Sec62 revealed that the protein is acetylated at the N-terminal methionine and two internal lysine residues.	Lysine	131-137	SEC62 homolog, preprotein translocation factor	Homo sapiens	39-44
28521986-1	2017	In this study glucose reinforced Fe3O4@cellulose glyconanoparticles (MGN) were prepared using epichlorohydrin and amino acid (lysine and arginine) as a linker.	Lysine	126-132	helt bHLH transcription factor	Homo sapiens	69-72
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	46-49	serine and arginine rich splicing factor 2	Homo sapiens	86-129
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	46-49	serine and arginine rich splicing factor 2	Homo sapiens	131-136
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	191-194	serine and arginine rich splicing factor 2	Homo sapiens	86-129
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	191-194	serine and arginine rich splicing factor 2	Homo sapiens	131-136
29228645-4	2017	Sumoylation of Snail1 lysine residue 234 confers its transcriptional activity, inducing the expression of classical EMT genes, as well as TGFbeta receptor I (TbetaRI) and the transcriptional repressor Hes1.	Lysine	22-28	hes family bHLH transcription factor 1	Homo sapiens	201-205
28607146-7	2017	Tup1 promotes memory-specific chromatin changes at the GAL1 promoter: incorporation of histone variant H2A.Z and dimethylation of histone H3, lysine 4.	Lysine	142-148	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	0-4
28751611-4	2017	We found that Ltn1p efficiently accessed only nascent-chain lysines immediately proximal to the ribosome exit tunnel.	Lysine	60-67	ubiquitin-protein ligase RKR1	Saccharomyces cerevisiae S288C	14-19
28751611-5	2017	For substrates without Ltn1p-accessible lysines, CAT-tailing enabled degradation by exposing lysines sequestered in the ribosome exit tunnel.	Lysine	40-47	ubiquitin-protein ligase RKR1	Saccharomyces cerevisiae S288C	23-28
28751611-5	2017	For substrates without Ltn1p-accessible lysines, CAT-tailing enabled degradation by exposing lysines sequestered in the ribosome exit tunnel.	Lysine	93-100	ubiquitin-protein ligase RKR1	Saccharomyces cerevisiae S288C	23-28
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Lysine	6-12	Janus kinase 2	Homo sapiens	81-85
28639750-4	2017	We found that SMYD3 trimethylates HER2 protein at lysine 175.	Lysine	50-56	SET and MYND domain containing 3	Homo sapiens	14-19
28639750-8	2017	Our results imply that SMYD3-mediated methylation of HER2 at Lysine 175 may regulate the formation of HER2 homodimer and subsequent autophosphorylation and suggest that the SMYD3-mediated methylation pathway seems to be a good target for development of novel anti-cancer therapy.	Lysine	61-67	SET and MYND domain containing 3	Homo sapiens	23-28
28639750-8	2017	Our results imply that SMYD3-mediated methylation of HER2 at Lysine 175 may regulate the formation of HER2 homodimer and subsequent autophosphorylation and suggest that the SMYD3-mediated methylation pathway seems to be a good target for development of novel anti-cancer therapy.	Lysine	61-67	SET and MYND domain containing 3	Homo sapiens	173-178
28315733-6	2017	Moreover, EZH2-mediated silencing of SFRP-1 was due to increased histone 3 lysine 27 trimethylation (H3K27me3) on its promoter region.	Lysine	75-81	secreted frizzled related protein 1	Homo sapiens	37-43
28511916-7	2017	Quantitative chromatin immunoprecipitation assay revealed that amitriptyline increased enrichments of trimethylation of histone H3 lysine 4 in the promoter regions of Atf3 and Hmox1 and acetylation of histone H3 lysine 9 in the promoter regions of Atf3, which indicate an active epigenetic status.	Lysine	131-137	activating transcription factor 3	Mus musculus	167-171
28445029-5	2017	Surprisingly, we also show that fragment-based NHS-ester ligands can be made to confer selectivity for specific lysine hotspots on specific targets including Dpyd, Aldh2, and Gstt1.	Lysine	112-118	aldehyde dehydrogenase 2 family member	Homo sapiens	164-169
28391595-2	2017	Here, we describe that lysine-368 of human citrate synthase is methylated and that the modifying enzyme, localized in the mitochondrial matrix, is methyltransferase-like protein 12 (METTL12), a member of the family of 7beta-strand methyltransferases.	Lysine	23-29	citrate synthase	Homo sapiens	43-59
28391595-3	2017	Lysine-368 is near the active site of citrate synthase, but removal of methylation has no effect on its activity.	Lysine	0-6	citrate synthase	Homo sapiens	38-54
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	0-3	glass bottom boat	Drosophila melanogaster	36-43
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	glass bottom boat	Drosophila melanogaster	36-43
28377500-6	2017	Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.	Lysine	134-137	glass bottom boat	Drosophila melanogaster	36-43
28542143-0	2017	DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.	Lysine	141-147	baculoviral IAP repeat containing 2	Homo sapiens	65-70
28542143-2	2017	Here, we demonstrated that the E3-ubiquitin ligase cellular inhibitor of apoptosis 1 (cIAP1) increases E2F1 K63-poly-ubiquitination on the lysine residue 161/164 cluster, which is associated with the transcriptional factor stability and activity.	Lysine	139-145	baculoviral IAP repeat containing 2	Homo sapiens	86-91
28542143-3	2017	Mutation of these lysine residues completely abrogates the binding of E2F1 to CCNE, TP73 and APAF1 promoters, thus inhibiting transcriptional activation of these genes and E2F1-mediated cell proliferation control.	Lysine	18-24	tumor protein p73	Homo sapiens	84-88
28542145-7	2017	TRIM45 conjugates K63-linked polyubiquitin chain to the C-terminal six lysine residues of p53, thereby inhibiting the availability of these residues to the K48-linked polyubiquitination that targets p53 for degradation.	Lysine	71-77	tripartite motif containing 45	Homo sapiens	0-6
28763789-0	2017	Ubiquitination of STING at lysine 224 controls IRF3 activation.	Lysine	27-33	interferon regulatory factor 3	Homo sapiens	47-51
28498016-3	2017	VIN3 is induced by long-term cold and is necessary for Polycomb Repression Complex 2 (PRC2)-mediated tri-methylation of Histone H3 Lysine 27 (H3K27me3) at the FLC locus in Arabidopsis.	Lysine	131-137	Fibronectin type III domain-containing protein	Arabidopsis thaliana	0-4
25660027-6	2015	The sites of ubiquitination were mapped to Lys-868 in GluA1 and Lys-870/Lys-882 in GluA2 C-terminals.	Lysine	64-67	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	83-88
25660027-6	2015	The sites of ubiquitination were mapped to Lys-868 in GluA1 and Lys-870/Lys-882 in GluA2 C-terminals.	Lysine	64-67	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	83-88
25519227-3	2015	We calculate the temperature (Theta) and frequency (omega) dependences of the spin-lattice NMR relaxation rates for segments and NMR active CH2 groups in poly-L-lysine (PLL) dendrimers in water, on the basis of full-atomic molecular dynamics simulations.	Lysine	154-167	interleukin 1 receptor like 1	Homo sapiens	52-57
25472959-8	2015	Patients with T2DM showed Set7-dependent monomethylation of lysine 4 of histone 3 on NF-kB p65 promoter.	Lysine	60-66	RELA proto-oncogene, NF-kB subunit	Homo sapiens	91-94
25315187-8	2015	Further mass spectrometry analysis indicated that both ACAT1 and MnSOD had characterized acetylation at lysine residues, which is the first time to identify acetylation of ACAT1 and MnSOD in ccRCC.	Lysine	104-110	superoxide dismutase 2	Homo sapiens	65-70
25315187-8	2015	Further mass spectrometry analysis indicated that both ACAT1 and MnSOD had characterized acetylation at lysine residues, which is the first time to identify acetylation of ACAT1 and MnSOD in ccRCC.	Lysine	104-110	superoxide dismutase 2	Homo sapiens	182-187
25505183-6	2015	The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when docked in AS PKCdelta, and this interaction prevented the potential interaction of ATP with Lys-378, Glu-428, Leu-430, and Phe-633 residues.	Lysine	170-173	protein kinase C delta	Homo sapiens	91-99
25505263-5	2015	Acetyl mutagenesis of Hsp10 lysine 56 alters Hsp10-Hsp60 binding, conformation, and protein folding.	Lysine	28-34	heat shock protein family E (Hsp10) member 1	Homo sapiens	22-27
25505263-5	2015	Acetyl mutagenesis of Hsp10 lysine 56 alters Hsp10-Hsp60 binding, conformation, and protein folding.	Lysine	28-34	heat shock protein family E (Hsp10) member 1	Homo sapiens	45-50
25564843-2	2015	The Pf1 helix tilt angles in bilayers composed of two different lipids are not entirely governed by the membrane thickness but could be rationalized by hydrophobic interactions of lysines at the bilayer interface.	Lysine	180-187	PHD finger protein 12	Homo sapiens	4-7
26317124-5	2015	Hem12 contains three conserved lysine residues located on the protein surface that can potentially be ubiquitinated and lysine K8 is close to the 36-LPEY-39 (PY) motif which binds WW domains of the Rsp5 ligase.	Lysine	31-37	uroporphyrinogen decarboxylase HEM12	Saccharomyces cerevisiae S288C	0-5
28503659-2	2015	As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16.	Lysine	115-121	lysine acetyltransferase 8	Homo sapiens	15-19
28503659-2	2015	As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16.	Lysine	115-121	lysine acetyltransferase 8	Homo sapiens	57-60
25205713-9	2015	Arg and Lys residues located within the 40 residue spanning connecting peptide of fetuin-A were identified as cleavage sites for matriptase-2.	Lysine	8-11	transmembrane serine protease 6	Mus musculus	129-141
25459750-9	2015	SUV39H2 can transfer up to three methyl groups to lysine 9 of histone H3 but the last methylation reaction is much slower than the first two steps.	Lysine	50-56	SUV39H2 histone lysine methyltransferase	Homo sapiens	0-7
26697838-4	2015	Furthermore, we discovered that Skp2 could interact with Aurora B and trigger Aurora B Lysine (K) 63-linked ubiquitination.	Lysine	87-93	S-phase kinase associated protein 2	Homo sapiens	32-36
25687468-4	2015	Many developmental genes are trimethylated at histone H3 lysine 27 (H3K27me3) mediated by PRC2, which provides a binding site for PRC1.	Lysine	57-63	protein regulator of cytokinesis 1	Homo sapiens	130-134
25323651-7	2015	We also show that transcriptional inactive Gas41 mutant interferes with the functional assembly of heterochromatin-associated proteins, dimethylated lysine 9 of histone H3 and heterochromatic protein 1 in developing embryos.	Lysine	149-155	Gas41	Drosophila melanogaster	43-48
25238203-9	2015	ASH1L and MLL1, which belong to the Trithorax group (TrxG) proteins and are major regulators of Homeobox gene expression, maintain active target gene transcription by histone 3 lysine 4 methylation.	Lysine	177-183	ASH1 like histone lysine methyltransferase	Homo sapiens	0-5
25601683-0	2015	Lysine residues in the N-terminal huntingtin amphipathic alpha-helix play a key role in peptide aggregation.	Lysine	0-6	huntingtin	Homo sapiens	34-44
25601683-8	2015	Evidence for protected residues is observed in the 17-residue N-terminal tract and specifically points to lysine residues as potentially playing a significant role in htt aggregation.	Lysine	106-112	huntingtin	Homo sapiens	167-170
24940804-4	2015	Proteomic analysis showed that SIRT1 deacetylates HMGB1 at four lysine residues (55, 88, 90, and 177) within the proinflammatory and nuclear localization signal domains of HMGB1.	Lysine	64-70	high mobility group box 1	Homo sapiens	50-55
24940804-4	2015	Proteomic analysis showed that SIRT1 deacetylates HMGB1 at four lysine residues (55, 88, 90, and 177) within the proinflammatory and nuclear localization signal domains of HMGB1.	Lysine	64-70	high mobility group box 1	Homo sapiens	172-177
25736763-2	2015	Within the seven NF-kappaB family proteins, the RelA subunit of NF-kappaB is the most studied for its regulation by lysine acetylation and methylation.	Lysine	116-122	RELA proto-oncogene, NF-kB subunit	Homo sapiens	48-52
26322575-4	2015	Recently, it has been demonstrated that Arabidopsis RACK1 is phosphorylated by an atypical serine/threonine protein kinase, WITH NO LYSINE 8 (WNK8).	Lysine	132-138	with no lysine (K) kinase 8	Arabidopsis thaliana	142-146
25497092-4	2014	PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha, which subsequently triggers its proteasomal degradation and suppresses its transcriptional activity.	Lysine	20-26	K(lysine) acetyltransferase 2B	Mus musculus	0-4
25497092-4	2014	PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha, which subsequently triggers its proteasomal degradation and suppresses its transcriptional activity.	Lysine	20-26	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	53-63
25542019-2	2014	In this study, we discovered that JARID2, an interacting component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (H3K27), was involved in Transforming Growth Factor-beta (TGF-ss)-induced epithelial-mesenchymal transition (EMT) of A549 lung cancer cell line and HT29 colon cancer cell line.	Lysine	137-143	jumonji and AT-rich interaction domain containing 2	Homo sapiens	34-40
25287050-2	2014	The conjugation of RNase A with 4-nitrophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzyl carbonate (NBC) blocks protein lysine and temporarily deactivates the protein.	Lysine	132-138	ribonuclease A family member 1, pancreatic	Homo sapiens	19-26
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	66-70
25450384-2	2014	Upregulation of lysine (K)-specific demethylase 5B (KDM5B) has been reported in a variety of malignant tumors.	Lysine	16-22	lysine demethylase 5B	Homo sapiens	52-57
25185627-1	2014	OBJECTIVES: The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin.	Lysine	131-137	lysyl oxidase like 1	Homo sapiens	16-21
25185627-1	2014	OBJECTIVES: The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin.	Lysine	131-137	lysyl oxidase like 1	Homo sapiens	23-43
25609594-4	2014	RESULTS: We found that ethanol treatment of P7 mice enhances acetylation of H4 on lysine 8 (H4K8ace) at CB1R exon1, CB1R binding as well as the CB1R agonist-stimulated GTPgammaS binding in the hippocampus and neocortex, two brain regions that are vulnerable to ethanol at P7 and are important for memory formation and storage, respectively.	Lysine	82-88	cannabinoid receptor 1 (brain)	Mus musculus	104-108
25355358-2	2014	This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys 119 using its E3 ubiquitin ligase subunits, Ring1B and Bmi1, together with an E2 ubiquitin-conjugating enzyme, UbcH5c.	Lysine	106-109	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	165-169
25356675-11	2014	CONCLUSIONS/SIGNIFICANCE: The exclusive detection of PTMs on lysine residues within LipL32 from in vivo-isolated L. interrogans implies that infection-generated modification of leptospiral proteins may have a biologically relevant function during the course of infection.	Lysine	61-67	parathymosin	Rattus norvegicus	53-57
25196843-6	2014	Alanine substitutions at HO-2 residues Leu-201 and Lys-169 cause a respective 3- and 22-fold increase in K(m) values for CPR, consistent with a role for these residues in CPR binding.	Lysine	51-54	heme oxygenase 2	Homo sapiens	25-29
25339290-4	2014	RESULTS: Here, we identified the lysine 327 within the CXCR2 C-terminal tail as a key residue for ubiquitination, internalization, and signaling.	Lysine	33-39	C-X-C motif chemokine receptor 2	Homo sapiens	55-60
25193658-4	2014	Mutating several lysines of the gamma2IL into arginines makes the gamma2 subunit resistant to RNF34-induced degradation.	Lysine	17-24	crystallin, gamma E	Rattus norvegicus	32-38
25058340-15	2014	It is adjacent to Lys-114, a known residue on globular-actin-binding site, implying that oxidation of Met-115 disrupts the globular-actin-binding site of cofilin, which causes TnCl-induced inactivation.	Lysine	18-21	cofilin 1	Homo sapiens	154-161
25135475-6	2014	Our subsequent analyses revealed that CTCF facilitates the stabilization of Polycomb repressive complex 2 (PRC2) and trimethylated lysine 27 of histone H3 (H3K27me3) at the human HOXA locus.	Lysine	131-137	homeobox A cluster	Homo sapiens	179-183
25111069-4	2014	Herein, we investigated a carbamoyl phosphate synthetase 1 derived peptide substrate and modified the lysine side chain systematically to determine the acyl specificity of Sirt5.	Lysine	102-108	sirtuin 5	Homo sapiens	172-177
25254379-5	2014	Interestingly, RNF26 promoted K11-linked polyubiquitination of MITA at lysine 150, a residue also targeted by RNF5 for K48-linked polyubiquitination.	Lysine	71-77	stimulator of interferon response cGAMP interactor 1	Homo sapiens	63-67
25056949-2	2014	We have shown previously that, following TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a regulatory role in TNFR signaling.	Lysine	104-107	ZFP36 ring finger protein	Homo sapiens	79-94
25056949-2	2014	We have shown previously that, following TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a regulatory role in TNFR signaling.	Lysine	104-107	ZFP36 ring finger protein	Homo sapiens	96-99
25056949-4	2014	This regulatory function toward JNK activation but not NF-kappaB activation depends on lysine 105 of TTP, which we identified as the corresponding TRAF2 ubiquitination site.	Lysine	87-93	ZFP36 ring finger protein	Homo sapiens	101-104
25189210-2	2014	Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3.2 T-type channel and modifies specific lysine residues in this region.	Lysine	227-233	WW domain containing E3 ubiquitin protein ligase 1	Mus musculus	64-68
24797412-6	2014	Besides, the physiological role of newly identified lysine acylation mediated by Sirt5 and its biochemical effects on oxidative metabolism are also discussed.	Lysine	52-58	sirtuin 5	Homo sapiens	81-86
25148519-10	2014	The two sites within proSAAS that are known to be efficiently cleaved by furin were altered by site-directed mutagenesis to convert the P4 Arg into Lys; this change converts the sequences from furin consensus sites into prohormone convertase consensus sites.	Lysine	148-151	furin (paired basic amino acid cleaving enzyme)	Mus musculus	73-78
25148519-10	2014	The two sites within proSAAS that are known to be efficiently cleaved by furin were altered by site-directed mutagenesis to convert the P4 Arg into Lys; this change converts the sequences from furin consensus sites into prohormone convertase consensus sites.	Lysine	148-151	furin (paired basic amino acid cleaving enzyme)	Mus musculus	193-198
25032507-1	2014	The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).	Lysine	4-10	lysine methyltransferase 5A	Homo sapiens	29-34
24840043-1	2014	HLCS (holocarboxylase synthetase) is a nuclear protein that catalyses the binding of biotin to distinct lysine residues in chromatin proteins.	Lysine	104-110	holocarboxylase synthetase	Homo sapiens	0-4
24840043-1	2014	HLCS (holocarboxylase synthetase) is a nuclear protein that catalyses the binding of biotin to distinct lysine residues in chromatin proteins.	Lysine	104-110	holocarboxylase synthetase	Homo sapiens	6-32
24997987-5	2014	In addition, two amino acid substitutions in the extracellular domain of HLA-DQalpha1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60x10(-10)) and of HLA-DQbeta1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20x10(-9)) independently confer achalasia risk.	Lysine	102-108	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	120-128
24981174-6	2014	RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients.	Lysine	107-113	BAG cochaperone 6	Homo sapiens	52-56
24981174-6	2014	RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients.	Lysine	107-113	BAG cochaperone 6	Homo sapiens	126-130
25012259-3	2014	L-Lysine monooxygenase (DavB) and 5-aminovaleramide amidohydrolase (DavA) play key roles in the biotransformation of L-lysine into 5-aminovalerate.	Lysine	117-125	FAD-dependent oxidoreductase	Pseudomonas putida KT2440	24-28
25012259-4	2014	Here, DavB and DavA of P. putida KT2440 were expressed, purified, and coupled for the production of 5-aminovalerate from L-lysine.	Lysine	121-129	FAD-dependent oxidoreductase	Pseudomonas putida KT2440	6-10
25003393-7	2014	Deprotonation of the substrate lysine by D117 on UbcH5A occurs with almost no energy barrier as calculated by MD and QM/MM calculations.	Lysine	31-37	ubiquitin conjugating enzyme E2 D1	Homo sapiens	49-55
24841206-7	2014	ENaC cleavage and activation by trypsin IV but not by trypsin I required a critical cleavage site (Lys-189) in the extracellular domain of the gamma-subunit.	Lysine	99-102	serine protease 3	Homo sapiens	32-42
24723426-6	2014	Mechanistically, we found that lnc-IL7R knockdown diminished trimethylation of histone H3 at lysine 27 (H3K27me3), a hallmark of silent transcription, at the proximal promoters of the inflammatory mediators.	Lysine	93-99	interleukin 7 receptor	Homo sapiens	35-39
24779776-4	2014	Tri-methylation of lysine 4 on histone H3 (H3K4) enhanced at the promoter of HSP104, PRO1, TPS1 and SOD1 in ethanol-tolerant variants of S. cerevisiae was also diminished after tenth passage in stress-free cultures.	Lysine	19-25	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	77-83
24779776-4	2014	Tri-methylation of lysine 4 on histone H3 (H3K4) enhanced at the promoter of HSP104, PRO1, TPS1 and SOD1 in ethanol-tolerant variants of S. cerevisiae was also diminished after tenth passage in stress-free cultures.	Lysine	19-25	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	100-104
28330936-3	2017	Here, we show that ALD1 transfers the alpha-amino group of l-Lys to acceptor oxoacids.	Lysine	59-64	AGD2-like defense response protein 1	Arabidopsis thaliana	19-23
28330936-6	2017	However, detailed in planta analyses suggest that the biosynthesis of 2,3-DP from l-Lys is the major in vivo function of ALD1.	Lysine	82-87	AGD2-like defense response protein 1	Arabidopsis thaliana	121-125
28406396-0	2017	SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.	Lysine	46-52	sirtuin 6	Homo sapiens	0-5
28406396-4	2017	SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.	Lysine	75-81	sirtuin 6	Homo sapiens	0-5
28406396-7	2017	Our study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras family of GTPases and provides an important mechanism by which SIRT6 functions as a tumor suppressor.	Lysine	22-28	sirtuin 6	Homo sapiens	165-170
29069627-8	2017	Our results suggest that SUMOylation of Src at lysine 318 negatively modulate its oncogenic function by, at least partially, inhibiting Src-FAK complex activity.	Lysine	47-53	protein tyrosine kinase 2	Homo sapiens	140-143
24877974-8	2014	We also determined that the localization of p39 to lamellipodia requires myristoylation and Lys clusters within the N-terminal p10 region.	Lysine	92-95	S100 calcium binding protein A10 (calpactin)	Mus musculus	127-130
28786345-3	2017	METHOD: BET proteins act as "epigenetic readers" and bind to acetylated lysine residues on the tails of histones H3 and H4.	Lysine	72-78	delta/notch like EGF repeat containing	Homo sapiens	8-11
24971881-2	2014	We report that both small ubiquitin-like modifier (SUMO) 1 and SUMO2/3 modify ALS-linked SOD1 mutant proteins at lysine 75 in a motoneuronal cell line, the cell type affected in ALS.	Lysine	113-119	small ubiquitin like modifier 1	Homo sapiens	20-58
28302677-8	2017	Here, we describe that substituting Lys-119/Arg-120 and Lys-125 residues in the predicted integrin-binding interface of FGF2 to glutamic acid (the K119E/R120E and K125E mutations) effectively reduced integrin binding to FGF2.	Lysine	36-39	fibroblast growth factor 2	Mus musculus	120-124
28302677-8	2017	Here, we describe that substituting Lys-119/Arg-120 and Lys-125 residues in the predicted integrin-binding interface of FGF2 to glutamic acid (the K119E/R120E and K125E mutations) effectively reduced integrin binding to FGF2.	Lysine	56-59	fibroblast growth factor 2	Mus musculus	120-124
28302792-1	2017	Epigenetic inheritance models posit that during Polycomb repression, Polycomb repressive complex 2 (PRC2) propagates histone H3 lysine 27 trimethylation (H3K27me3) independently of DNA sequence.	Lysine	128-134	Polycomb	Drosophila melanogaster	69-77
29138491-5	2017	We further identify that the putative SUMOylation site of Bombyx Plk1 at lysine 466 is required for its localization on centrosomes, and K466 mutation in Plk1 could influence its interaction with Smt3/Ubc9 complex.	Lysine	73-79	serine/threonine-protein kinase polo	Bombyx mori	65-69
28121484-10	2017	Interestingly, SYVN1-mediated lysine 48 (K48)-linked polyubiquitin chains that conjugated onto SERPINA1E342K/ATZ might predominantly bind to the ubiquitin-associated (UBA) domain of SQSTM1 and couple the ubiquitinated SERPINA1E342K/ATZ to the lysosome for degradation.	Lysine	30-36	synoviolin 1	Homo sapiens	15-20
24927133-3	2014	The methyltransferase activity of NSD1 is retained in the fusion, and it gives rise to abnormally high levels of methylation at lysine 36 on histone 3, enforcing oncogene activation.	Lysine	128-134	nuclear receptor binding SET domain protein 1	Homo sapiens	34-38
29109511-3	2017	We report that DDB2 promotes CPD excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3.	Lysine	110-116	damage specific DNA binding protein 2	Homo sapiens	15-19
24488929-5	2014	Further studies reveal that lysine 85 in the carboxyl terminus of Tat is critical for its interaction with Eg5 and hence its effects on Eg5 activity, mitotic progression, and apoptosis.	Lysine	28-34	tyrosine aminotransferase	Homo sapiens	66-69
28320505-1	2017	RNA polymerase II-interacting the Set2 methyltransferase co-transcriptionally methylates histone H3 at lysine 36 within the body of genes.	Lysine	103-109	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	34-38
29109511-3	2017	We report that DDB2 promotes CPD excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3.	Lysine	110-116	ASH1 like histone lysine methyltransferase	Homo sapiens	86-91
28947664-6	2017	PRC1 and PRC2 complexes catalyse specific histone post-translational modifications (PTMs), ubiquitylation of histone H2A at position lysine 119 (H2AK119u1) and methylation of histone H3 at position lysine 27 (H3K27me3), respectively, and accordingly, these modifications are highly enriched over the length of the inactive X chromosome (Xi).	Lysine	133-139	protein regulator of cytokinesis 1	Homo sapiens	0-4
28212515-6	2017	After adjustment for drinking behaviors, compared to individuals with ALDH2 Glu/Glu, the ORs of ever smoking were 1.71 (95% CI, 1.49-1.95) and 2.28 (1.81-2.87) among those with ALDH2 Glu/Lys and Lys/Lys, respectively.	Lysine	187-190	aldehyde dehydrogenase 2 family member	Homo sapiens	177-182
28212515-6	2017	After adjustment for drinking behaviors, compared to individuals with ALDH2 Glu/Glu, the ORs of ever smoking were 1.71 (95% CI, 1.49-1.95) and 2.28 (1.81-2.87) among those with ALDH2 Glu/Lys and Lys/Lys, respectively.	Lysine	195-198	aldehyde dehydrogenase 2 family member	Homo sapiens	177-182
28212515-6	2017	After adjustment for drinking behaviors, compared to individuals with ALDH2 Glu/Glu, the ORs of ever smoking were 1.71 (95% CI, 1.49-1.95) and 2.28 (1.81-2.87) among those with ALDH2 Glu/Lys and Lys/Lys, respectively.	Lysine	195-198	aldehyde dehydrogenase 2 family member	Homo sapiens	177-182
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	lysine acetyltransferase 2B	Homo sapiens	275-301
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	lysine acetyltransferase 2B	Homo sapiens	303-307
28947664-6	2017	PRC1 and PRC2 complexes catalyse specific histone post-translational modifications (PTMs), ubiquitylation of histone H2A at position lysine 119 (H2AK119u1) and methylation of histone H3 at position lysine 27 (H3K27me3), respectively, and accordingly, these modifications are highly enriched over the length of the inactive X chromosome (Xi).	Lysine	198-204	protein regulator of cytokinesis 1	Homo sapiens	0-4
23770847-3	2014	API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-kappaB activation.	Lysine	46-52	MALT1 paracaspase	Homo sapiens	5-10
28901377-10	2017	Reverse transcription-quantitative polymerase chain reaction analysis demonstrated that BCE reduced mRNA expression of the genomic caretaker lysine-specific demethylas  5B (KDM5B).	Lysine	141-147	lysine demethylase 5B	Homo sapiens	173-178
24803536-1	2014	WNK1 [with no lysine (K)] is a serine-threonine kinase associated with a form of familial hypertension.	Lysine	14-20	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
27721400-7	2017	Acetylation at lysine-68 (K68) inhibits MnSOD catalytic activity and thus represents an important post-translational regulatory mechanism in human cells.	Lysine	15-21	superoxide dismutase 2	Homo sapiens	40-45
28967912-1	2017	Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by KMT2C) and MLL4 (encoded by KMT2D) in mammals.	Lysine	11-17	trithorax-related	Drosophila melanogaster	178-181
28332566-6	2017	The WAVE2 ubiquitylation site was mapped to lysine 45, located at the N-terminus where WAVE2 binds to the WRC.	Lysine	44-50	WASP family member 2	Homo sapiens	4-9
28332566-6	2017	The WAVE2 ubiquitylation site was mapped to lysine 45, located at the N-terminus where WAVE2 binds to the WRC.	Lysine	44-50	WASP family member 2	Homo sapiens	87-92
24803536-5	2014	Crystallographic studies of inactive WNK1 in the presence of chloride revealed that chloride binds directly to the catalytic site, providing a basis for the unique position of the catalytic lysine.	Lysine	190-196	WNK lysine deficient protein kinase 1	Homo sapiens	37-41
28967912-1	2017	Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by KMT2C) and MLL4 (encoded by KMT2D) in mammals.	Lysine	11-17	lysine (K)-specific methyltransferase 2C	Mus musculus	213-217
24634223-0	2014	Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.	Lysine	29-35	PR/SET domain 9	Homo sapiens	66-71
28901481-1	2017	NSD3 is a histone lysine methyltransferase that methylates histone H3 at lysine 36.	Lysine	18-24	nuclear receptor binding SET domain protein 3	Homo sapiens	0-4
24763053-11	2014	In conclusion, we found that ESET regulated SSC apoptosis by suppressing of Cox4i2 expression through histone H3 lysine 9 tri-methylation and DNA methylation.	Lysine	113-119	cytochrome c oxidase subunit 4I2	Homo sapiens	76-82
28216326-2	2017	HLCC formation is initiated by lysyl hydroxylase 2 (LH2), an Fe(II) and alpha-ketoglutarate (alphaKG)-dependent oxygenase that hydroxylates telopeptidyl lysine residues on collagen.	Lysine	153-159	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	31-50
28216326-2	2017	HLCC formation is initiated by lysyl hydroxylase 2 (LH2), an Fe(II) and alpha-ketoglutarate (alphaKG)-dependent oxygenase that hydroxylates telopeptidyl lysine residues on collagen.	Lysine	153-159	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	52-55
28887308-0	2017	Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.	Lysine	132-138	citrate synthase	Homo sapiens	77-93
28326190-6	2017	Mechanistically, in the proliferating myoblasts, Malat1 recruits Suv39h1 to MyoD-binding loci, causing trimethylation of histone 3 lysine 9 (H3K9me3), which suppresses the target gene expression.	Lysine	131-137	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	49-55
24742347-9	2014	ISG activation depends on Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters and a single exon Tat protein more strongly modulated the luciferase activity mediated by MAP2K3, MAP2K6, and IRF7 promoter sequences located 5" of the RNA start site than the wild type two-exon Tat, while a cysteine and lysine Tat mutants, reduced in LTR transactivation, had negligible effects on these promoters.	Lysine	303-309	tyrosine aminotransferase	Homo sapiens	100-103
24742347-9	2014	ISG activation depends on Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters and a single exon Tat protein more strongly modulated the luciferase activity mediated by MAP2K3, MAP2K6, and IRF7 promoter sequences located 5" of the RNA start site than the wild type two-exon Tat, while a cysteine and lysine Tat mutants, reduced in LTR transactivation, had negligible effects on these promoters.	Lysine	303-309	tyrosine aminotransferase	Homo sapiens	100-103
24742347-9	2014	ISG activation depends on Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters and a single exon Tat protein more strongly modulated the luciferase activity mediated by MAP2K3, MAP2K6, and IRF7 promoter sequences located 5" of the RNA start site than the wild type two-exon Tat, while a cysteine and lysine Tat mutants, reduced in LTR transactivation, had negligible effects on these promoters.	Lysine	303-309	tyrosine aminotransferase	Homo sapiens	100-103
28887308-4	2017	Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site.	Lysine	93-96	citrate synthase	Homo sapiens	87-89
28126738-3	2017	In the present study, we show that PRDM9 performs intramolecular automethylation on multiple lysine residues localised to a lysine-rich region on the post-SET (suppressor of variegation 3-9, enhancer of zeste and trithorax) domain.	Lysine	93-99	PR/SET domain 9	Homo sapiens	35-40
28887308-4	2017	Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site.	Lysine	93-96	citrate synthase	Homo sapiens	128-130
28126738-3	2017	In the present study, we show that PRDM9 performs intramolecular automethylation on multiple lysine residues localised to a lysine-rich region on the post-SET (suppressor of variegation 3-9, enhancer of zeste and trithorax) domain.	Lysine	124-130	PR/SET domain 9	Homo sapiens	35-40
29061669-6	2017	Finally, the analysis of HDA14 loss-of-function mutants revealed that the activation state of RuBisCO is controlled by lysine acetylation of RuBisCO activase under low-light conditions.	Lysine	119-125	histone deacetylase 14	Arabidopsis thaliana	25-30
28296597-3	2017	Here we show that E1 upregulates HSD17B4 acetylation at lysine 669 (K669) and thereby promotes HSD17B4 degradation via chaperone-mediated autophagy (CMA), while a single mutation at K669 reverses the degradation and confers migratory and invasive properties to MCF7 cells upon E1 treatment.	Lysine	56-62	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	33-40
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	36-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-88
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	36-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-88
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	67-70	RELA proto-oncogene, NF-kB subunit	Homo sapiens	14-17
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	67-70	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-88
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	67-70	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-88
23624912-5	2014	Lys-62 residue of p65 was required for ING4-mediated ubiquitination of p65 and degradation.	Lysine	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-21
23624912-5	2014	Lys-62 residue of p65 was required for ING4-mediated ubiquitination of p65 and degradation.	Lysine	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	71-74
28248992-2	2017	BET proteins bind to acetylated lysine residues in the histones of nucleosomal chromatin and function either as co-activators or co-repressors of gene expression.	Lysine	32-38	delta/notch like EGF repeat containing	Homo sapiens	0-3
29123987-2	2017	Jun dimerization protein 2 (JDP2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence through recruitment of the Polycomb repressive complexes 1 and 2 to the promoter of the gene that encodes p16Ink4a and inhibits the methylation of lysine 27 of the histone H3 locus.	Lysine	259-265	Jun dimerization protein 2	Mus musculus	0-26
24717514-10	2014	NNMT inhibition increases adipose SAM and NAD(+) levels and upregulates ODC and SSAT activity as well as expression, owing to the effects of NNMT on histone H3 lysine 4 methylation in adipose tissue.	Lysine	160-166	spermidine/spermine N1-acetyl transferase 1	Mus musculus	80-84
29123987-2	2017	Jun dimerization protein 2 (JDP2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence through recruitment of the Polycomb repressive complexes 1 and 2 to the promoter of the gene that encodes p16Ink4a and inhibits the methylation of lysine 27 of the histone H3 locus.	Lysine	259-265	Jun dimerization protein 2	Mus musculus	28-32
28958848-4	2017	As predicted based on SIRT6 biological roles, the new leads increase histone 3 lysine 9 acetylation and glucose uptake in cultured cells, while blocking TNF-alpha production and T lymphocyte proliferation.	Lysine	79-85	sirtuin 6	Homo sapiens	22-27
24478033-6	2014	Removal of kringle V or the strong lysine binding site in kringle IV10 completely abolished the inhibitory effect of apo(a).	Lysine	35-41	lipoprotein(a)	Homo sapiens	117-123
28357416-3	2017	However, we have recently discovered a novel KMT that appeared to have a more relaxed sequence specificity, namely, valosin-containing protein (VCP)-KMT, which trimethylates Lys-315 in the molecular chaperone VCP.	Lysine	174-177	valosin containing protein	Homo sapiens	144-147
28357416-4	2017	On the basis of this, here, we explored the possibility of using the VCP-KMT/VCP system to obtain specific lysine methylation of desired sequences grafted onto a VCP-derived scaffold.	Lysine	107-113	valosin containing protein	Homo sapiens	69-72
28357416-4	2017	On the basis of this, here, we explored the possibility of using the VCP-KMT/VCP system to obtain specific lysine methylation of desired sequences grafted onto a VCP-derived scaffold.	Lysine	107-113	valosin containing protein	Homo sapiens	77-80
28893534-3	2017	Regulation of these steps requires successive binding of MED26 N-terminal domain (NTD) to TATA-binding protein-associated factor 7 (TAF7) and Eleven-nineteen lysine-rich in leukemia-Associated Factor 1 (EAF1).	Lysine	158-164	ELL associated factor 1	Homo sapiens	203-207
28357416-5	2017	We generated VCP-derived proteins in which three amino acid residues on each side of Lys-315 had been replaced by various sequences representing lysine methylation sites in histone H3.	Lysine	85-88	valosin containing protein	Homo sapiens	13-16
28357416-5	2017	We generated VCP-derived proteins in which three amino acid residues on each side of Lys-315 had been replaced by various sequences representing lysine methylation sites in histone H3.	Lysine	145-151	valosin containing protein	Homo sapiens	13-16
24489122-9	2014	Finally, in these RA-triggered repressive chromatin-remodeling processes, lysine acetylation of RIP140 is critical for its recruiting Brm.	Lysine	74-80	nuclear receptor interacting protein 1	Homo sapiens	96-102
24489122-9	2014	Finally, in these RA-triggered repressive chromatin-remodeling processes, lysine acetylation of RIP140 is critical for its recruiting Brm.	Lysine	74-80	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	134-137
29018572-3	2017	Here we found that HOXA10 was modified by small ubiquitin like-modifier 1 (SUMO1) at the evolutionarily conserved lysine 164 residue.	Lysine	114-120	homeobox A10	Homo sapiens	19-25
24517223-3	2014	TGase allows the modification of proteins at the level of Gln or Lys residues using as substrate an alkyl-amine or a Gln-mimicking moiety, respectively.	Lysine	65-68	transglutaminase 1	Homo sapiens	0-5
24517223-8	2014	On the other hand, incubation of avidin with TGase in the presence of carbobenzoxy-l-glutaminyl-glycine in order to derivatize Lys residue(s) resulted in a clean and high yield production of an avidin derivative, retaining the biotin binding properties and the quaternary structure of the native protein.	Lysine	127-130	transglutaminase 1	Homo sapiens	45-50
28249157-0	2017	Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.	Lysine	31-37	hydroxyacylglutathione hydrolase	Homo sapiens	133-146
28249161-3	2017	Here we show that the SETD8/PR-Set7 methyltransferase, which catalyzes mono-methylation of histone H4 at lysine 20 (H4K20me1), suppresses nucleolar and mitochondrial activities to prevent cellular senescence.	Lysine	105-111	lysine methyltransferase 5A	Homo sapiens	22-27
29018572-3	2017	Here we found that HOXA10 was modified by small ubiquitin like-modifier 1 (SUMO1) at the evolutionarily conserved lysine 164 residue.	Lysine	114-120	small ubiquitin like modifier 1	Homo sapiens	42-73
28230157-4	2017	Using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metalloproteinases (MMP2 and MMP9), we demonstrated that substrates containing ACC/Lys(DNP) exhibit 7 to 10 times higher sensitivity than conventional 7-methoxy-coumarin-4-yl acetic acid (MCA)/Lys(DNP) substrates; thus, substantially lower amounts of substrate and enzyme can be used for each assay.	Lysine	168-171	elastase, neutrophil expressed	Homo sapiens	39-58
29018572-3	2017	Here we found that HOXA10 was modified by small ubiquitin like-modifier 1 (SUMO1) at the evolutionarily conserved lysine 164 residue.	Lysine	114-120	small ubiquitin like modifier 1	Homo sapiens	75-80
28230157-4	2017	Using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metalloproteinases (MMP2 and MMP9), we demonstrated that substrates containing ACC/Lys(DNP) exhibit 7 to 10 times higher sensitivity than conventional 7-methoxy-coumarin-4-yl acetic acid (MCA)/Lys(DNP) substrates; thus, substantially lower amounts of substrate and enzyme can be used for each assay.	Lysine	168-171	matrix metallopeptidase 2	Homo sapiens	105-109
24614341-7	2014	The lysine residues 224 and 548 of RRM1 were identified as major ubiquitination sites.	Lysine	4-10	ribonucleotide reductase catalytic subunit M1	Homo sapiens	35-39
28981631-7	2017	Mapping of SUMO-modified sites demonstrated that UVR-induced SUMOylation occurs on Lys-309 residue of DDB2 protein.	Lysine	83-86	damage specific DNA binding protein 2	Homo sapiens	102-106
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	123-128
28124276-2	2017	Proteolytic activation of TAFI by thrombin, thrombin in complex with the endothelial cell cofactor thrombomodulin, or plasmin results in an enzyme (TAFIa) that removes carboxyl-terminal lysine residues from protein and peptide substrates, including cell-surface plasminogen receptors.	Lysine	186-192	carboxypeptidase B2	Homo sapiens	26-30
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Lysine	53-56	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
24415668-5	2014	To understand which primary sequence elements determine the filament severing activity of the WH2 repeats, here we combine a mutagenetic/domain swapping approach of the minimal fully active Cobl-KAB construct, which comprises the lysine rich region K preceding the two first WH2 domains A and B.	Lysine	230-236	cordon-bleu WH2 repeat protein	Homo sapiens	190-194
28743636-5	2017	To confirm the mechanism of valproate-mediated increase in DAT mRNA, chromatin immunoprecipitation (ChIP) assays were used and demonstrated a significant increase in enrichment of acetylation of histone 3 on lysines 9 and 14 (H3K9/K14ac) in the DAT promoter.	Lysine	208-215	solute carrier family 6 member 3	Rattus norvegicus	59-62
24452550-1	2014	The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16.	Lysine	209-215	lysine acetyltransferase 8	Homo sapiens	14-17
28031478-2	2017	Here, we show that TRIM65 specifically interacts with MDA5 and promotes K63-linked ubiquitination of MDA5 at lysine 743, which is critical for MDA5 oligomerization and activation.	Lysine	109-115	tripartite motif containing 65	Homo sapiens	19-25
29156681-3	2017	It removes di- and mono- methyl residues from di- or mono-methylated lysine 9 of histone H3 (H3K9me2/me1).	Lysine	69-75	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	101-104
27927750-4	2017	PRC2 (via EZH2) mediates histone 3 lysine 27 (H3K27) trimethylation, and PRC1 (via RING1B) mediates histone 2A lysine 119 (H2AK119) monoubiquitination.	Lysine	111-117	protein regulator of cytokinesis 1	Homo sapiens	73-77
23435416-10	2014	Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that the interaction of JARID2 at these promoters is dependent on EED, a core component of the polycomb repressive complex 2 (PRC2).	Lysine	92-98	jumonji and AT-rich interaction domain containing 2	Homo sapiens	28-34
23435416-10	2014	Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that the interaction of JARID2 at these promoters is dependent on EED, a core component of the polycomb repressive complex 2 (PRC2).	Lysine	92-98	myogenin	Homo sapiens	129-133
23435416-10	2014	Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that the interaction of JARID2 at these promoters is dependent on EED, a core component of the polycomb repressive complex 2 (PRC2).	Lysine	92-98	jumonji and AT-rich interaction domain containing 2	Homo sapiens	171-177
27965024-0	2017	A novel GLP-1 analog, a dimer of GLP-1 via covalent linkage by a lysine, prolongs the action of GLP-1 in the treatment of type 2 diabetes.	Lysine	65-71	glucagon	Mus musculus	8-13
28931919-5	2017	RORalpha2 requires lysine specific demethylase 1 (LSD1/KDM1A) as a coactivator for transcriptional activation of RORalpha2 target genes, exemplified by CTNND1.	Lysine	19-25	catenin delta 1	Homo sapiens	152-158
27965024-0	2017	A novel GLP-1 analog, a dimer of GLP-1 via covalent linkage by a lysine, prolongs the action of GLP-1 in the treatment of type 2 diabetes.	Lysine	65-71	glucagon	Mus musculus	33-38
27965024-0	2017	A novel GLP-1 analog, a dimer of GLP-1 via covalent linkage by a lysine, prolongs the action of GLP-1 in the treatment of type 2 diabetes.	Lysine	65-71	glucagon	Mus musculus	33-38
27965024-3	2017	Here we have chosen the idea to dimerize GLP-1 with a C-terminal lysine to form a new GLP-1 analog, DLG3312.	Lysine	65-71	glucagon	Mus musculus	86-91
27965024-10	2017	In conclusion, we, by using C-terminal lysine as a linker, have synthesized a novel GLP-1 analog, DLG3312.	Lysine	39-45	glucagon	Mus musculus	84-89
24412544-1	2014	The nuclear receptor binding SET [su(var) 3-9, enhancer of zeste, trithorax] domain-containing protein 1 (NSD1) protein lysine methyltransferase (PKMT) was known to methylate histone H3 lysine 36 (H3K36).	Lysine	120-126	nuclear receptor binding SET domain protein 1	Homo sapiens	106-110
28647331-0	2017	Combination of histidine, lysine, methionine, and leucine promotes beta-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells.	Lysine	26-32	mechanistic target of rapamycin kinase	Bos taurus	97-128
24529102-11	2014	Among a panel of B-lymphoma cell lines, low-level expression of full-length p300 protein, which is characteristic of the SUDHL2 and RC-K8 cells, was associated with decreased acetylation of histone H3 at lysines 14 and 18.	Lysine	204-211	E1A binding protein p300	Homo sapiens	76-80
28188267-8	2017	Importantly, CDKD;2 and SPT5 are required for the deposition of VIP5 and the enhancement of trimethylation of histone 3 lysine 4 in the chromatin of the FLC locus.	Lysine	120-126	SPT5 homolog, DSIF elongation factor subunit	Homo sapiens	24-28
28851851-8	2017	These finding raise the possibility of some convergent similarities of PbZfp functions to functions of mammalian PRDM9, also a C2H2 ZnF protein with histone 3 lysine 4 (H3K4) methyltransferase activity.	Lysine	159-165	PR/SET domain 9	Homo sapiens	113-118
28000813-3	2017	In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells.	Lysine	167-170	furin, paired basic amino acid cleaving enzyme	Homo sapiens	218-223
24048683-9	2014	In the metabolomics analysis of hepatic NAFLD samples, several changes were opposite to what has been reported in plasma of HCC patients (lysine, phenylalanine, citrulline, creatine, creatinine, glycodeoxycholic acid, inosine, and alpha-ketoglutarate).	Lysine	138-144	HCC	Homo sapiens	124-127
28759294-6	2017	The p300/PCAF inhibitor garcinol also destabilized the ADA3 protein in a proteasome-dependent manner and an ADA3 mutant with K R mutations exhibited a marked increase in half-life, consistent with opposite role of acetylation and ubiquitination of ADA3 on shared lysine residues.	Lysine	263-269	E1A binding protein p300	Homo sapiens	4-8
24269899-10	2014	Further studies demonstrated a significant increase in posttranslational modifications of tyrosine and lysine residues in MnSOD protein and oxidation of Cys at the active site (Cys32 and Cys35) and the regulatory site (Cys62 and Cys69) of Trx1 in high-grade PCa compared to BN tissues.	Lysine	103-109	superoxide dismutase 2	Homo sapiens	122-127
28271031-7	2017	RESULTS: Acute administration of GLP-2 increased basal AA absorption in vivo and augmented basal lysine transport ex vivo.	Lysine	97-103	glucagon-like peptide 2 receptor	Mus musculus	33-38
28271031-8	2017	GLP-2-stimulated lysine transport was attenuated by co-incubation with wortmannin, rapamycin, or tetrodotoxin ex vivo.	Lysine	17-23	glucagon-like peptide 2 receptor	Mus musculus	0-5
28271031-11	2017	Disruption of GLP-2 action in Glp2r-/- mice reduced lysine transport ex vivo and attenuated the phosphorylation of S6 and 4E-BP1 in response to oral protein.	Lysine	52-58	glucagon-like peptide 2 receptor	Mus musculus	14-19
28271031-11	2017	Disruption of GLP-2 action in Glp2r-/- mice reduced lysine transport ex vivo and attenuated the phosphorylation of S6 and 4E-BP1 in response to oral protein.	Lysine	52-58	glucagon-like peptide 2 receptor	Mus musculus	30-35
28793258-3	2017	Here, we report that AMPARs are subject to lysine acetylation at their C termini.	Lysine	43-49	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	21-27
28028228-1	2017	Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in the overreplication of heterochromatin.	Lysine	53-59	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	138-143
28028228-1	2017	Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in the overreplication of heterochromatin.	Lysine	53-59	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	145-150
24438103-5	2014	SOCS3-induced polyubiquitination was rapid and could proceed through a number of different ubiquitin lysines.	Lysine	101-108	suppressor of cytokine signaling 3	Homo sapiens	0-5
24028840-1	2014	Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins.	Lysine	108-114	carboxypeptidase N, polypeptide 1	Mus musculus	0-18
24028840-1	2014	Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins.	Lysine	108-114	carboxypeptidase N, polypeptide 1	Mus musculus	20-23
28793258-5	2017	Through competition for the same lysine residues, acetylation intensity is inversely related to the levels of AMPAR ubiquitination.	Lysine	33-39	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	110-115
28793258-9	2017	These findings establish SIRT2-regulated lysine acetylation as a form of AMPAR post-translational modification that regulates its turnover, as well as synaptic plasticity and cognitive function.	Lysine	41-47	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	73-78
28790309-4	2017	In addition to optimally functioning with an E2 that solely performs transthiolation, our data suggests that HHARI prevents spurious discharge of Ub from E2 to lysine residues by: (1) harboring structural elements that block E2 ~ Ub from adopting a "closed" conformation and (2) participating in contacts to ubiquitin that promote an open E2 ~ Ub conformation.HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase.	Lysine	160-166	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	109-114
24357096-9	2014	RESULTS: The results suggests a protective effect of the genotypes Arg/Lys of AhR rs2066853 (odds ratio [OR] 0.55, p = 0.03), Ile/Val of CYP1A1 rs1048943 (OR 0.49, p = 0.009), Tyr/His of EPHX1 rs1051740 (OR 0.53, p = 0.03), and A/A of CCND1 rs603965 (OR 0.44, p = 0.02).	Lysine	71-74	aryl hydrocarbon receptor	Homo sapiens	78-81
28055018-3	2017	We identified lysines (K) 122 and 142 as the major Sumo1 conjugation sites in Prdx6.	Lysine	14-21	small ubiquitin like modifier 1	Homo sapiens	51-56
28055018-3	2017	We identified lysines (K) 122 and 142 as the major Sumo1 conjugation sites in Prdx6.	Lysine	14-21	peroxiredoxin 6	Homo sapiens	78-83
23318425-4	2014	DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.	Lysine	138-144	DNA methyltransferase 1 associated protein 1	Homo sapiens	0-26
28790309-4	2017	In addition to optimally functioning with an E2 that solely performs transthiolation, our data suggests that HHARI prevents spurious discharge of Ub from E2 to lysine residues by: (1) harboring structural elements that block E2 ~ Ub from adopting a "closed" conformation and (2) participating in contacts to ubiquitin that promote an open E2 ~ Ub conformation.HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase.	Lysine	160-166	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	360-365
23318425-4	2014	DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.	Lysine	138-144	DNA methyltransferase 1 associated protein 1	Homo sapiens	28-33
28452589-1	2017	Lysyl oxidase (LOX) catalyzes the oxidative deamination of lysine residues in collagen and elastin, key components of connective tissue.	Lysine	59-65	lysyl oxidase	Mus musculus	0-13
28452589-1	2017	Lysyl oxidase (LOX) catalyzes the oxidative deamination of lysine residues in collagen and elastin, key components of connective tissue.	Lysine	59-65	lysyl oxidase	Mus musculus	15-18
28571745-5	2017	Acetylation of MKL1 was necessary for MKL1 to activate the transcription of pro-inflammatory genes because mutation of four conserved lysine residues in MKL1 attenuated its capacity as a trans-activator of NF-kappaB target genes.	Lysine	134-140	myocardin related transcription factor A	Homo sapiens	15-19
27820805-4	2017	Crystal structures of p300 in complex with propionyl-, crotonyl-, or butyryl-CoA show that the aliphatic portions of these cofactors are bound in the lysine substrate-binding tunnel in a conformation that is incompatible with substrate transfer.	Lysine	150-156	E1A binding protein p300	Homo sapiens	22-26
24364624-8	2014	The NMR structure indicates that Sma0114 lacks Y-T coupling and that communication between the active site and the 455 face is achieved through a conserved lysine residue that stabilizes the acyl phosphate in receiver domains.	Lysine	156-162	survival of motor neuron 1, telomeric	Homo sapiens	33-36
28606761-1	2017	Bromodomain-containing protein 9 (BRD9), an epigenetic "reader" of acetylated lysines on post-translationally modified histone proteins, is upregulated in multiple cancer cell lines.	Lysine	78-85	bromodomain containing 9	Homo sapiens	0-32
24076356-8	2014	When comparing the myoglobin sequence from TA with the Ovis aries myoglobin sequence, variations were observed at codons 21 (GGT GAT) and 78 (GAA AAG), and these variations lead to changes in the corresponding amino acids, i.e., Gly Asp and Glu Lys, respectively.	Lysine	245-248	myoglobin	Ovis aries	66-75
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	tripartite motif containing 25	Homo sapiens	142-169
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	tripartite motif containing 25	Homo sapiens	171-177
27875302-0	2016	Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue.	Lysine	80-86	EWS RNA binding protein 1	Homo sapiens	31-34
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	59-65	EWS RNA binding protein 1	Homo sapiens	154-157
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	101-104	EWS RNA binding protein 1	Homo sapiens	154-157
27375026-5	2016	We show that although the C"-terminal Lys residue of Wnt3a is critical for its activity and is important for the effect of CPE on the Wnt pathway, CPE does not execute its effect by removing this Wnt3a residue.	Lysine	38-41	Wnt family member 3A	Homo sapiens	53-58
27375026-5	2016	We show that although the C"-terminal Lys residue of Wnt3a is critical for its activity and is important for the effect of CPE on the Wnt pathway, CPE does not execute its effect by removing this Wnt3a residue.	Lysine	38-41	Wnt family member 3A	Homo sapiens	53-56
27829226-6	2016	We found that MAFB could be SUMOylated by SUMO1 at lysine 32, and this modification was critical for cell cycle regulation by MAFB in CRC cells.	Lysine	51-57	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	Mus musculus	14-18
27777308-4	2016	The TCR-induced generation of Lin(Ub)n-Bcl10 requires Bcl10 lysines 17, 31, and 63, CARD11, MALT1, and the HOIP subunit of the linear ubiquitin chain assembly complex (LUBAC) but not the HOIP accessory protein SHARPIN.	Lysine	60-67	BCL10 immune signaling adaptor	Homo sapiens	39-44
27777308-4	2016	The TCR-induced generation of Lin(Ub)n-Bcl10 requires Bcl10 lysines 17, 31, and 63, CARD11, MALT1, and the HOIP subunit of the linear ubiquitin chain assembly complex (LUBAC) but not the HOIP accessory protein SHARPIN.	Lysine	60-67	BCL10 immune signaling adaptor	Homo sapiens	54-59
27733371-6	2016	MYD88 activity was directly regulated through lysine acetylation and was deacetylated by HDAC6.	Lysine	46-52	MYD88 innate immune signal transduction adaptor	Homo sapiens	0-5
27658392-4	2016	We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to the consensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked polyubiquitination, predominantly at the lysine 100 residue.	Lysine	199-205	ring finger protein 123	Mus musculus	16-32
27696497-1	2016	The KDM5C gene (also known as JARID1C and SMCX) is located on the X chromosome and encodes a ubiquitously expressed 1560-aa protein, which plays an important role in lysine methylation (specifically reverses tri- and di-methylation of Lys4 of histone H3).	Lysine	166-172	lysine demethylase 5C	Homo sapiens	4-9
27696497-1	2016	The KDM5C gene (also known as JARID1C and SMCX) is located on the X chromosome and encodes a ubiquitously expressed 1560-aa protein, which plays an important role in lysine methylation (specifically reverses tri- and di-methylation of Lys4 of histone H3).	Lysine	166-172	lysine demethylase 5C	Homo sapiens	30-37
27696497-1	2016	The KDM5C gene (also known as JARID1C and SMCX) is located on the X chromosome and encodes a ubiquitously expressed 1560-aa protein, which plays an important role in lysine methylation (specifically reverses tri- and di-methylation of Lys4 of histone H3).	Lysine	166-172	lysine demethylase 5C	Homo sapiens	42-46
27720608-4	2016	Importantly, VGLL4 acetylation at lysine 225 negatively regulated its binding to TEAD1.	Lysine	34-40	vestigial like family member 4	Homo sapiens	13-18
27821753-4	2016	In a mutant line deficient for ATXR5 or ATXR6-dependent histone H3 lysine 27 (H3K27) monomethylation, we show that millions of base pairs of chromosome 4, including the telomere, TEL4N, and much of NOR4, have been converted to the corresponding sequences of chromosome 2.	Lysine	67-73	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	40-45
27661393-11	2016	In conclusion, the position of the Lys (positively charged amino acid) influences the receptor binding, internalization, in vivo NTR1-targeting efficacy, and kidney retention profile of the radioconjugates.	Lysine	35-38	neurotensin receptor 1	Homo sapiens	129-133
27647933-6	2016	Finally, while acetylation of Pygo2 had little effect on active beta-catenin complex formation, p300-mediated Pygo2 acetylation resulted in the displacement of Pygo2 from the nucleus to the cytoplasm by targeting specific lysine residues in the Pygo2 nuclear localization sequence.	Lysine	222-228	E1A binding protein p300	Homo sapiens	96-100
27819327-8	2016	Site-directed mutagenesis experiments have implicated a basic surface including the side chains of Arg 6, His 11 and Lys 32 as potentially important in the FS50 NaV1.5 interaction.	Lysine	117-120	sodium voltage-gated channel alpha subunit 5	Rattus norvegicus	161-167
27542907-0	2016	TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.	Lysine	16-22	CREB regulated transcription coactivator 1	Mus musculus	78-84
27542907-3	2016	This study analyzes tuberous sclerosis complex (TSC2) lysine acetylation, in the regulation of mTORC1 signaling activation, autophagy and cell proliferation.	Lysine	54-60	CREB regulated transcription coactivator 1	Mus musculus	95-101
27542907-9	2016	We also observed that two TSC2 lysine mutants in its N-terminal domain, derived from TSC patients, differentially modulate mTORC1 signaling.	Lysine	31-37	CREB regulated transcription coactivator 1	Mus musculus	123-129
27542907-12	2016	This study provides, for the first time, a relationship between TSC2 lysine acetylation status and its stability, representing a novel mechanism for regulating mTORC1 pathway.	Lysine	69-75	CREB regulated transcription coactivator 1	Mus musculus	160-166
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Lysine	18-21	caspase 1	Mus musculus	157-166
27594515-2	2016	We recently identified SETD2 as a dual-function histone and microtubule methyltransferase, and methylation as a new microtubule PTM that occurs on lysine 40 of alpha-tubulin, which is trimethylated (alpha-TubK40me3) by SETD2.	Lysine	147-153	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	23-28
27534420-4	2016	Here we show, by chromatin immunoprecipitation, that UV-B exposure of Arabidopsis increases acetylation of lysines K9 and/or K14 of histone H3 at UVR8-regulated gene loci in a UVR8-dependent manner.	Lysine	107-114	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	146-150
27534420-4	2016	Here we show, by chromatin immunoprecipitation, that UV-B exposure of Arabidopsis increases acetylation of lysines K9 and/or K14 of histone H3 at UVR8-regulated gene loci in a UVR8-dependent manner.	Lysine	107-114	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	176-180
27805607-10	2016	However, SBDS possesses several cysteines and lysines that did not allow site directed labeling of it.	Lysine	46-53	SBDS ribosome maturation factor	Homo sapiens	9-13
27357307-1	2016	The unique amino acid hypusine is present in only two proteins in eukaryotic cells, eukaryotic translation initiation factor 5A-1 (eIF5A1), and eIF5A2, where it is covalently linked to the lysine-50 residue of these proteins via a post-translational modification coined hypusination.	Lysine	189-195	eukaryotic translation initiation factor 5A2	Homo sapiens	144-150
27454617-5	2016	The molecular docking studies were performed to elucidate the binding modes of the compounds with the GSK-3beta target and two crucial interactions namely, hydrogen bond formation with Val 135 and Lys 183 residues in the active site of GSK-3beta were observed.	Lysine	197-200	glycogen synthase kinase 3 beta	Homo sapiens	102-111
27454617-5	2016	The molecular docking studies were performed to elucidate the binding modes of the compounds with the GSK-3beta target and two crucial interactions namely, hydrogen bond formation with Val 135 and Lys 183 residues in the active site of GSK-3beta were observed.	Lysine	197-200	glycogen synthase kinase 3 beta	Homo sapiens	236-245
27924120-8	2016	GO analysis showed involvement of GH 38 and ATXR 6 in glycan and lysine degradation pathways.	Lysine	65-71	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	44-50
27564657-1	2016	BACKGROUND: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a proenzyme that, once activated, attenuates fibrinolysis by removing C-terminal lysine residues from partially degraded fibrin.	Lysine	147-153	carboxypeptidase B2	Homo sapiens	12-55
27489104-4	2016	The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.	Lysine	19-22	NFKB inhibitor zeta	Homo sapiens	86-97
27489104-4	2016	The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.	Lysine	31-34	NFKB inhibitor zeta	Homo sapiens	86-97
26898756-0	2016	A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.	Lysine	73-79	sirtuin 6	Homo sapiens	44-49
27611194-8	2016	As results presented show, a poly-L-lysine (PLL) pre-coat significantly enhances detection of antibodies to DNA as well as antigens such as histones, SSA, SSB and RNP.	Lysine	29-42	small RNA binding exonuclease protection factor La	Homo sapiens	155-158
27551082-8	2016	Surprisingly, His378Arg/Lys variants do not degrade in light despite maintaining reactivity toward TIM, thereby implicating different conformational responses in these two functions.	Lysine	24-27	timeless	Drosophila melanogaster	99-102
27470515-7	2016	Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells.	Lysine	10-16	calnexin	Homo sapiens	82-90
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Lysine	133-136	bombesin receptor subtype 3	Homo sapiens	57-60
27618414-11	2016	Activity of ALDH was suppressed in the diabetic retina and blockade of ALDH1a1 in cultured Muller glia triggered FDP-lysine accumulation and reduced cell viability.	Lysine	117-123	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	12-16
27556810-7	2016	Nav1.9 Domain 2 S6 pore domain contains a unique lysine residue (K799) which is predicted to be spatially near the local anesthetic interaction site.	Lysine	49-55	neuron navigator 1	Homo sapiens	0-4
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	158-164	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	97-120
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	158-164	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	122-127
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	240-246	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	97-120
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	240-246	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	122-127
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	240-246	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	97-120
27518565-3	2016	We show that methylation is a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible for H3 lysine 36 trimethylation (H3K36me3) of histones, also methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules.	Lysine	240-246	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	122-127
27501389-4	2016	Surprisingly, despite our presumptions, we found that Ubc9 fused to TTR was SUMOylated at a unique set of lysine residues.	Lysine	106-112	ubiquitin conjugating enzyme E2 I	Homo sapiens	54-58
27501389-7	2016	SUMOylation of the lysine residues of TTR fused to Ubc9 was hardly detectable.	Lysine	19-25	ubiquitin conjugating enzyme E2 I	Homo sapiens	51-55
27191891-7	2016	SETD2 is now generally known as the single human gene responsible for trimethylation of lysine 36 of Histone H3 (H3K36).	Lysine	88-94	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
27083448-2	2016	Here, we investigate immunoreactivity against the euchromatic histone-lysine N-methyltransferase EHMT2 and its catalyzed mono- and dimethylation marks at histone 3 lysine 9 (H3K9me1 and H3K9me2) during postnatal differentiation of the mouse central auditory system.	Lysine	70-76	euchromatic histone lysine N-methyltransferase 2	Mus musculus	97-102
27264558-8	2016	The features of the DPC formation in vivo are exactly in keeping with the mechanistic properties seen in vitro: Polbeta-DPC are formed by oxidative agents in line with their ability to form the dL lesion; they are not formed by non-oxidative agents; DPC formation absolutely requires the active-site lysine-72 that attacks the 5"-deoxyribose; and DPC formation depends on Ape1 to incise the dL lesion first.	Lysine	300-306	DNA polymerase beta	Homo sapiens	112-119
27302062-10	2016	Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.	Lysine	116-122	ubiquitin specific peptidase 8	Homo sapiens	30-34
27152839-4	2016	Based on the fact that Sirt6 has an enhanced activity to remove long chain fatty acylation from lysine, we developed an approach to recombinantly synthesize histone H3 with a fatty acylated lysine, N(epsilon)-(7-octenoyl)-lysine (OcK), installed at a number of lysine sites and used these acyl-H3 proteins to assemble acyl-nucleosomes as active Sirt6 substrates.	Lysine	96-102	sirtuin 6	Homo sapiens	23-28
27152839-4	2016	Based on the fact that Sirt6 has an enhanced activity to remove long chain fatty acylation from lysine, we developed an approach to recombinantly synthesize histone H3 with a fatty acylated lysine, N(epsilon)-(7-octenoyl)-lysine (OcK), installed at a number of lysine sites and used these acyl-H3 proteins to assemble acyl-nucleosomes as active Sirt6 substrates.	Lysine	190-196	sirtuin 6	Homo sapiens	23-28
27152839-4	2016	Based on the fact that Sirt6 has an enhanced activity to remove long chain fatty acylation from lysine, we developed an approach to recombinantly synthesize histone H3 with a fatty acylated lysine, N(epsilon)-(7-octenoyl)-lysine (OcK), installed at a number of lysine sites and used these acyl-H3 proteins to assemble acyl-nucleosomes as active Sirt6 substrates.	Lysine	190-196	sirtuin 6	Homo sapiens	23-28
27152839-7	2016	Overexpressing Sirt6 in 293T cells led to downregulated acetylation at H3K18 and K3K27, confirming these two novel Sirt6-targeted nucleosome lysine sites in cells.	Lysine	141-147	sirtuin 6	Homo sapiens	15-20
27152839-7	2016	Overexpressing Sirt6 in 293T cells led to downregulated acetylation at H3K18 and K3K27, confirming these two novel Sirt6-targeted nucleosome lysine sites in cells.	Lysine	141-147	sirtuin 6	Homo sapiens	115-120
26972532-8	2016	The ratio of regulatory T cells after the administration of MDP-Lys (L18) was significantly decreased in Rnf213-deficient mice (p&lt;0.01), suggesting the potential role of the RNF213 abnormality in the differentiation of regulatory T cells.	Lysine	64-67	ring finger protein 213	Mus musculus	105-111
26972532-8	2016	The ratio of regulatory T cells after the administration of MDP-Lys (L18) was significantly decreased in Rnf213-deficient mice (p&lt;0.01), suggesting the potential role of the RNF213 abnormality in the differentiation of regulatory T cells.	Lysine	64-67	ring finger protein 213	Mus musculus	177-183
27354553-6	2016	Loss of immunity in sdg mutants was attributed to altered global and CCR2- and CER3-specific histone lysine methylation (HLM).	Lysine	101-107	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	79-83
26800298-2	2016	It is often found covalently bound to lysine residues in proteins to form PLP dependent enzymes.	Lysine	38-44	pyridoxal phosphatase	Homo sapiens	74-77
27259994-4	2016	Site-directed mutagenesis revealed that acetylation at lysine (K) 64 of LKB1 triggers the formation of SIRT1/HERC2/LKB1 protein complex and subsequent proteasomal degradation.	Lysine	55-61	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	109-114
27315244-3	2016	We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425).	Lysine	147-153	IKAROS family zinc finger 1	Homo sapiens	13-19
27124586-1	2016	The Nepsilon-lysine acetylation of cargo proteins in the lumen of the endoplasmic reticulum (ER) requires a membrane transporter (SLC33A1) and 2 acetyltransferases (NAT8B and NAT8).	Lysine	13-19	N-acetyltransferase 8B, pseudogene	Mus musculus	165-170
27124586-1	2016	The Nepsilon-lysine acetylation of cargo proteins in the lumen of the endoplasmic reticulum (ER) requires a membrane transporter (SLC33A1) and 2 acetyltransferases (NAT8B and NAT8).	Lysine	13-19	N-acetyltransferase 8 (GCN5-related)	Mus musculus	165-169
26411363-5	2016	We identified two lysine residues located at the inter-SH2 domain on p85beta, a critical region required for inhibition of p110, as being required for SUMO conjugation.	Lysine	18-24	endogenous retrovirus group K member 15	Homo sapiens	123-127
27059328-9	2016	The mechanism of MLL2 regulation in blastocysts was assessed by assaying the trimethylation of histone 3 at lysine 4 (H3K4m3).	Lysine	108-114	lysine methyltransferase 2B	Homo sapiens	17-21
26802082-7	2016	Pharmacological inhibition of KAT2B by anacardic acid in NCM460 cells reduced the levels of histone H4 lysine 5 acetylation [H4K5ac] and interleukin-10 [IL-10] in a dose-dependent manner.	Lysine	103-109	lysine acetyltransferase 2B	Homo sapiens	30-35
27109047-7	2016	Furthermore, we found that ERG expression reduced histone H3 lysine 9 trimethylation at the YAP1 gene promoter, consistent with its epigenetic regulation through the ERG interaction partner, KDM4A.	Lysine	61-67	Yes1 associated transcriptional regulator	Homo sapiens	92-96
27216891-6	2016	Mechanistically, GCN5 regulated DKK1 expression by acetylation of Histone H3 lysine 9 (H3K9) and Histone H3 lysine 14 (H3K14) at its promoter region.	Lysine	77-83	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	32-36
27216891-6	2016	Mechanistically, GCN5 regulated DKK1 expression by acetylation of Histone H3 lysine 9 (H3K9) and Histone H3 lysine 14 (H3K14) at its promoter region.	Lysine	108-114	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	32-36
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Lysine	57-60	fibroblast growth factor 14	Homo sapiens	92-97
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Lysine	57-60	fibroblast growth factor 14	Homo sapiens	105-110
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	interferon beta 1	Homo sapiens	298-306
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	tripartite motif containing 25	Homo sapiens	142-169
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	tripartite motif containing 25	Homo sapiens	171-177
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	interferon beta 1	Homo sapiens	298-306
24399297-3	2014	Conversely, Lys(48)-linked ubiquitylation of TRIM25 by the linear ubiquitin assembly complex (LUBAC) stimulates the proteasomal degradation of TRIM25, thereby inhibiting the RIG-I signaling pathway.	Lysine	12-15	tripartite motif containing 25	Homo sapiens	45-51
24399297-3	2014	Conversely, Lys(48)-linked ubiquitylation of TRIM25 by the linear ubiquitin assembly complex (LUBAC) stimulates the proteasomal degradation of TRIM25, thereby inhibiting the RIG-I signaling pathway.	Lysine	12-15	tripartite motif containing 25	Homo sapiens	143-149
24399297-7	2014	In contrast, expression of wild-type USP15, but not its catalytically inactive mutant, reduced the Lys(48)-linked ubiquitylation of TRIM25, leading to its stabilization.	Lysine	99-102	tripartite motif containing 25	Homo sapiens	132-138
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	146-150
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	activator of HSP90 ATPase activity 1	Homo sapiens	156-159
24404182-6	2014	A methylome analysis of sg1 mutants revealed a large number of gene bodies hypermethylated in the cytosine CHG context, associated with an increase in di-methylation of lysine 9 on histone H3 tail (H3K9me2), an epigenetic mark normally found in silenced transposons.	Lysine	169-175	bromo-adjacent homology (BAH) domain-containing protein	Arabidopsis thaliana	24-27
24395240-5	2014	Acetylation of lysine residues of Hsp90 was recovered after treatment with deacetylase inhibitors, and acetylation-mimetic mutations (K27A and K271A) resulted in reduced virulence in a murine model of invasive aspergillosis, supporting their role in Hsp90 function.	Lysine	15-21	heat shock protein, 3	Mus musculus	34-39
24977164-3	2014	One of the most important PTMs is the Arg- or Lys-methylation that occurs on arginine or lysine, respectively.	Lysine	46-49	parathymosin	Homo sapiens	26-30
24977164-3	2014	One of the most important PTMs is the Arg- or Lys-methylation that occurs on arginine or lysine, respectively.	Lysine	89-95	parathymosin	Homo sapiens	26-30
24196443-0	2014	USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15.	Lysine	66-72	ubiquitin specific peptidase 3	Homo sapiens	0-4
24196443-0	2014	USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15.	Lysine	66-72	ring finger protein 168	Homo sapiens	17-23
24196443-0	2014	USP3 counteracts RNF168 via deubiquitinating H2A and gammaH2AX at lysine 13 and 15.	Lysine	66-72	H2A clustered histone 18	Homo sapiens	45-48
24196443-4	2014	This study demonstrated that USP3, an apparent DUB for mono-ubiquitinated H2A, is indeed the enzyme for deubiquitinating Ub conjugates of gammaH2AX and H2A from lysine sites, where the ubiquitination is initiated by RNF168.	Lysine	161-167	ubiquitin specific peptidase 3	Homo sapiens	29-33
24196443-4	2014	This study demonstrated that USP3, an apparent DUB for mono-ubiquitinated H2A, is indeed the enzyme for deubiquitinating Ub conjugates of gammaH2AX and H2A from lysine sites, where the ubiquitination is initiated by RNF168.	Lysine	161-167	H2A clustered histone 18	Homo sapiens	74-77
24196443-4	2014	This study demonstrated that USP3, an apparent DUB for mono-ubiquitinated H2A, is indeed the enzyme for deubiquitinating Ub conjugates of gammaH2AX and H2A from lysine sites, where the ubiquitination is initiated by RNF168.	Lysine	161-167	H2A clustered histone 18	Homo sapiens	143-146
24196443-4	2014	This study demonstrated that USP3, an apparent DUB for mono-ubiquitinated H2A, is indeed the enzyme for deubiquitinating Ub conjugates of gammaH2AX and H2A from lysine sites, where the ubiquitination is initiated by RNF168.	Lysine	161-167	ring finger protein 168	Homo sapiens	216-222
24196443-8	2014	We further identified that the USP3 removes Ub at lysine 13 and 15 of H2A and gammaH2AX, as well as lysine 118 and 119 of H2AX in response to DNA damage.	Lysine	50-56	ubiquitin specific peptidase 3	Homo sapiens	31-35
24196443-8	2014	We further identified that the USP3 removes Ub at lysine 13 and 15 of H2A and gammaH2AX, as well as lysine 118 and 119 of H2AX in response to DNA damage.	Lysine	50-56	H2A clustered histone 18	Homo sapiens	70-73
24196443-8	2014	We further identified that the USP3 removes Ub at lysine 13 and 15 of H2A and gammaH2AX, as well as lysine 118 and 119 of H2AX in response to DNA damage.	Lysine	50-56	H2A.X variant histone	Homo sapiens	83-87
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Lysine	32-38	angiotensin converting enzyme 2	Homo sapiens	55-59
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Lysine	32-38	angiotensin converting enzyme 2	Homo sapiens	138-142
24163256-2	2014	One such factor is Spt6, which couples transcription elongation with histone chaperone activity and the regulation of H3 lysine 36 methylation.	Lysine	121-127	SPT6 homolog, histone chaperone and transcription elongation factor	Homo sapiens	19-23
24118911-8	2014	Finally, we show that exposure of human PEX5 to oxidized glutathione results in a ubiquitination-deficient PEX5 molecule, and that substitution of Cys11 by a lysine can counteract this effect.	Lysine	158-164	peroxisomal biogenesis factor 5	Homo sapiens	40-44
24107421-2	2013	Gene targeting of the catalytic subunit (Slc7a9) in mice leads to excessive excretion of cystine, lysine, arginine, and ornithine.	Lysine	98-104	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	Mus musculus	41-47
24133061-4	2013	We used coimmunoprecipitation, mass spectrometry, and limited proteolysis assays to demonstrate that HSP72 interacts physically with the protein biotin ligase holocarboxylase synthetase (HLCS), leading to biotinylation of residues K112, K128 K348, K361, K415, and, probably, additional lysines.	Lysine	286-293	holocarboxylase synthetase	Homo sapiens	159-185
24133061-4	2013	We used coimmunoprecipitation, mass spectrometry, and limited proteolysis assays to demonstrate that HSP72 interacts physically with the protein biotin ligase holocarboxylase synthetase (HLCS), leading to biotinylation of residues K112, K128 K348, K361, K415, and, probably, additional lysines.	Lysine	286-293	holocarboxylase synthetase	Homo sapiens	187-191
24315375-7	2013	Taken together, these findings establish SIRT5 as a global regulator of lysine succinylation in mitochondria and present a mechanism for inhibition of ketogenesis through HMGCS2.	Lysine	72-78	sirtuin 5	Homo sapiens	41-46
24300896-0	2013	Lysine methylation promotes VEGFR-2 activation and angiogenesis.	Lysine	0-6	kinase insert domain protein receptor	Mus musculus	28-35
24300896-2	2013	We report the methylation of VEGFR-2 at multiple Lys and Arg residues, including Lys(1041), a residue that is proximal to the activation loop of the kinase domain.	Lysine	49-52	kinase insert domain protein receptor	Mus musculus	29-36
24300896-2	2013	We report the methylation of VEGFR-2 at multiple Lys and Arg residues, including Lys(1041), a residue that is proximal to the activation loop of the kinase domain.	Lysine	81-84	kinase insert domain protein receptor	Mus musculus	29-36
24300896-6	2013	We propose that methylation of Lys(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.	Lysine	31-34	kinase insert domain protein receptor	Mus musculus	68-75
24166615-8	2013	Our results provide compelling evidence that trimethylation of lysine residues within histones H3 and H4 is a novel mechanism involved in reducing C9orf72 mRNA expression in expanded repeat carriers.	Lysine	63-69	C9orf72-SMCR8 complex subunit	Homo sapiens	147-154
24100225-0	2013	Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP.	Lysine	54-60	valosin containing protein	Homo sapiens	100-107
24100010-4	2013	Furthermore, Spt6 is required for marks associated with active transcription, including trimethylation of histone H3 on lysine 4, previously observed in humans but not Saccharomyces cerevisiae, and lysine 36.	Lysine	120-126	SPT6 homolog, histone chaperone and transcription elongation factor	Homo sapiens	13-17
24100010-4	2013	Furthermore, Spt6 is required for marks associated with active transcription, including trimethylation of histone H3 on lysine 4, previously observed in humans but not Saccharomyces cerevisiae, and lysine 36.	Lysine	198-204	SPT6 homolog, histone chaperone and transcription elongation factor	Homo sapiens	13-17
23556418-7	2013	In addition, the lysine-sensitive AKs, AKLYS1 and AKLYS3 control the short- and long-term responses to perturbed lysine biosynthesis in Arabidopsis thaliana.	Lysine	17-23	aspartate kinase 1	Arabidopsis thaliana	39-45
23556418-7	2013	In addition, the lysine-sensitive AKs, AKLYS1 and AKLYS3 control the short- and long-term responses to perturbed lysine biosynthesis in Arabidopsis thaliana.	Lysine	113-119	aspartate kinase 1	Arabidopsis thaliana	39-45
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Lysine	97-100	insulin receptor	Homo sapiens	125-127
24191012-4	2013	Reducing IP6K1 levels by RNAi or using mouse embryonic fibroblasts derived from ip6k1(-/-) knockout mice results in a decreased IP7 concentration that epigenetically translates to reduced levels of trimethyl-histone H3 lysine 9 (H3K9me3) and increased levels of acetyl-H3K9.	Lysine	219-225	inositol hexaphosphate kinase 1	Mus musculus	9-14
23904295-5	2013	Alanine substitution of lysine residues K805/K806 in 804QKKHQIHK811 (motif 1 of Int1) markedly attenuated biofilm formation in central venous catheters in rats, whereas alanine substitution of K1595/R1596 in 1593FKKRFFKL1600 (motif 4 of Int1) did not impair biofilm formation.	Lysine	24-30	Wnt family member 1	Rattus norvegicus	80-84
23904295-5	2013	Alanine substitution of lysine residues K805/K806 in 804QKKHQIHK811 (motif 1 of Int1) markedly attenuated biofilm formation in central venous catheters in rats, whereas alanine substitution of K1595/R1596 in 1593FKKRFFKL1600 (motif 4 of Int1) did not impair biofilm formation.	Lysine	24-30	Wnt family member 1	Rattus norvegicus	237-241
24057246-2	2013	Comparisons among the three nucleotide sequences of three genotypes indicated that three base substitutions (A213T, A91G, and A89C) were detected in FSHbeta gene, which A213T substitution led to one amino acids mutation (Lys &gt; Met), and the other two substitutions were synonymous mutations.	Lysine	221-224	follitropin subunit beta	Ailuropoda melanoleuca	149-156
24032713-11	2013	In prostate epithelial cells, overexpression of DeltaS2 PRLR increased the levels of EZH2 methyltransferase mRNA and protein, induced EZH2 methyltransferase recruitment to chromatin, increased the trimethylation of histone 3 on lysine 27, and decreased expression of the p53 gene.	Lysine	228-234	prolactin receptor	Homo sapiens	56-60
24103193-9	2013	DHPS catalyzes the first step in hypusine formation, a unique amino acid formed by the posttranslational modification of the protein eukaryotic translation initiation factor 5A in a specific lysine residue.	Lysine	191-197	deoxyhypusine synthase	Sus scrofa	0-4
24116170-7	2013	Both IGF1 and GSK3i induced chromatin-level changes favoring transcriptional activation at the Kitl promoter including increased histone H3/H4 acetylation and H3 lysine (K) 4 methylation, reduced H3K9 and H3K27 methylation and reduced occupancy by the H3K27 methyltransferase EZH2.	Lysine	162-168	insulin-like growth factor 1	Mus musculus	5-9
23838343-1	2013	DAP epimerase is the penultimate enzyme in the lysine biosynthesis pathway.	Lysine	47-53	death associated protein	Homo sapiens	0-3
23907094-2	2013	We found that PCBs activate AR transcriptional activity and that this effect is potentiated by the demethylase Jarid1b, a histone demethylase that catalyzes the removal of trimethylation of lysine 4 on histone H3 (H3K4me3), induced by PCB.	Lysine	190-196	lysine demethylase 5B	Homo sapiens	111-118
24204298-11	2013	Repression of TER94 is attributable to spreading of the eve Pc domain into the TER94 locus, accompanied by an increase in histone H3 trimethylation at lysine 27.	Lysine	151-157	TER94	Drosophila melanogaster	14-19
23798677-5	2013	We also show that mutation of Asp-101, the intermolecular salt bridge partner of Lys-99, similarly blocks transformation of NIH3T3 cells by EN, reduces EN tyrosine phosphorylation, inhibits Akt and Mek1/2 signaling downstream of EN, and abolishes tumor formation in nude mice.	Lysine	81-84	mitogen-activated protein kinase kinase 1	Mus musculus	198-204
24074864-1	2013	Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	118-124	Polycomb	Drosophila melanogaster	0-8
24039885-3	2013	While investigating the role of Slk19 post-translational modification on Cdc14 regulation, we found that a triple point mutant of SLK19, slk19(3R) (three lysine-to-arginine mutations), strongly affects Cdc14 localization during late anaphase and mitotic exit.	Lysine	154-160	Slk19p	Saccharomyces cerevisiae S288C	130-135
24039885-3	2013	While investigating the role of Slk19 post-translational modification on Cdc14 regulation, we found that a triple point mutant of SLK19, slk19(3R) (three lysine-to-arginine mutations), strongly affects Cdc14 localization during late anaphase and mitotic exit.	Lysine	154-160	Slk19p	Saccharomyces cerevisiae S288C	137-142
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	114-120	sterile alpha and TIR motif containing 1	Homo sapiens	0-5
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	157-163	sterile alpha and TIR motif containing 1	Homo sapiens	0-5
24001316-1	2013	BACKGROUND: Polycomb Repressive Complex 2 (PRC2) is an essential regulator of gene expression that maintains genes in a repressed state by marking chromatin with trimethylated Histone H3 lysine 27 (H3K27me3).	Lysine	187-193	Polycomb	Drosophila melanogaster	12-20
24027420-0	2013	Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3zeta, MSK1, and MKP1.	Lysine	77-83	ribosomal protein S6 kinase A5	Homo sapiens	149-153
23863932-3	2013	Here we report that induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation (H4K16ac) through downregulation of the histone acetyltransferase hMOF (also called KAT8 or MYST1), and demonstrate that this histone modification regulates the outcome of autophagy.	Lysine	81-87	lysine acetyltransferase 8	Homo sapiens	169-173
23863932-3	2013	Here we report that induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation (H4K16ac) through downregulation of the histone acetyltransferase hMOF (also called KAT8 or MYST1), and demonstrate that this histone modification regulates the outcome of autophagy.	Lysine	81-87	lysine acetyltransferase 8	Homo sapiens	187-191
23932781-4	2013	Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation.	Lysine	27-33	lysine acetyltransferase 2B	Homo sapiens	114-118
23851690-7	2013	The NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific enrichment of histone 3 lysine 4 trimethylation (H3K4me3), which is indicative of open chromatin state and marks transcription-competent promoters.	Lysine	216-222	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	78-89
23542129-0	2013	Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1.	Lysine	15-21	nuclear receptor coactivator 2	Homo sapiens	86-131
23542129-5	2013	Three N-terminal sumoylation residues (Lys 65, 160, and 490) exhibited differential roles in the regulation of GRIP1 activity, and the sumoylation of Lys 490 acted as the primary nuclear localization signal of PML.	Lysine	39-42	nuclear receptor coactivator 2	Homo sapiens	111-116
23628702-1	2013	hMOF is the major acetyltransferase of histone H4 lysine 16 (H4K16) in humans, but its biological function is not well understood.	Lysine	50-56	lysine acetyltransferase 8	Homo sapiens	0-4
23783032-4	2013	We confirm biochemically that FANCL is polyubiquitinated with Lys-48-linked chains.	Lysine	62-65	FA complementation group L	Homo sapiens	30-35
23723241-4	2013	Emerging evidence has implicated a small number of histone methyltransferase (HMT) and histone demethylase (HDM) enzymes as regulators of ER signalling, including the histone H3 lysine 9 tri-/di-methyl HDM enzyme KDM4B.	Lysine	178-184	PR/SET domain 9	Homo sapiens	78-81
23870129-2	2013	Herein, we report that intracellular methionine and cysteine availability directly controls the thiolation status of wobble-uridine (U34) nucleotides present on lysine, glutamine, or glutamate tRNAs to regulate cellular translational capacity and metabolic homeostasis.	Lysine	161-167	small nucleolar RNA, C/D box 34	Homo sapiens	133-136
23855749-5	2013	We show, using molecular dynamics simulations, that the C84 fullerene with six lysine derivatives uniformly attached to its surface is selective to NavAb over a voltage-gated potassium channel (Kv1.3).	Lysine	79-85	potassium voltage-gated channel subfamily A member 3	Homo sapiens	194-199
23699598-8	2013	Nepsilon-fructosyl-lysine residue on plasminogen was increased in diabetes compared with controls (6.26 +- 3.43 and 1.82 +- 0.95%mol, respectively; P &lt; .01) with preferential glycation of lysines 107 and 557, sites involved in fibrin binding and plasmin(ogen) cleavage, respectively.	Lysine	191-198	plasminogen	Homo sapiens	37-44
23483050-1	2013	Our group has recently isolated and identified novel yellow compounds named dilysyl-dipyrrolones A (DPL A; 1) and B (DPL B; 2) in a heated aqueous solution containing xylose and lysine under weakly acidic conditions.	Lysine	178-184	prion like protein doppel	Homo sapiens	117-120
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Lysine	78-84	complement C6	Homo sapiens	97-100
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Lysine	78-84	prion like protein doppel	Homo sapiens	124-127
23673926-5	2013	The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), reduction of histone H3 or H4 acetylation and increased trimethylation of histone H3 lysine 9 as well as lysine 27 indicating that AML1-ETO induced heterochromatic silencing of Bcl-2, CEBPA and p14(ARF).	Lysine	199-205	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	30-33
23673926-5	2013	The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), reduction of histone H3 or H4 acetylation and increased trimethylation of histone H3 lysine 9 as well as lysine 27 indicating that AML1-ETO induced heterochromatic silencing of Bcl-2, CEBPA and p14(ARF).	Lysine	219-225	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	30-33
23665318-7	2013	Taken together, these findings suggest that APE1/Ref-1 is a protein whose secretion is governed by lysine acetylation.	Lysine	99-105	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	44-48
23665318-7	2013	Taken together, these findings suggest that APE1/Ref-1 is a protein whose secretion is governed by lysine acetylation.	Lysine	99-105	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	49-54
23755229-8	2013	APE1/Ref-1 also promotes lysine deacetylation of the SIRT1 target endothelial nitric oxide synthase (eNOS).	Lysine	25-31	apurinic/apyrimidinic endonuclease 1	Mus musculus	5-10
23755229-9	2013	SIRT1 mutated at cysteines 371 and 374, which renders it non-reducible by APE1/Ref-1, prevents lysine deacetylation of eNOS by APE1/Ref-1.	Lysine	95-101	apurinic/apyrimidinic endonuclease 1	Mus musculus	132-137
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Lysine	57-60	fibroblast growth factor 14	Homo sapiens	105-110
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Lysine	57-60	fibroblast growth factor 14	Homo sapiens	105-110
26945048-1	2016	CURLY LEAF (CLF), a histone methyltransferase of Polycomb Repressive Complex 2 (PRC2) for trimethylation of histone H3 Lys 27 (H3K27me3), has been thought as a negative regulator controlling mainly postgermination growth in Arabidopsis (Arabidopsis thaliana).	Lysine	119-122	SET domain-containing protein	Arabidopsis thaliana	12-15
26905748-6	2016	In cells over-expressing Sphk2, accumulation of Sa1P in the nuclear compartment inhibits histone deacetylase (HDAC) activity, causing increased acetylation of histone lysine residues.	Lysine	167-173	sphingosine kinase 2	Mus musculus	25-30
26596838-8	2016	Mass spectrometry analysis and immunoblotting identified 10 acetylated lysines on rp53, and molecular modeling showed that all lysines targeted by aspirin are surface exposed.	Lysine	71-78	retinol dehydrogenase 12	Homo sapiens	82-86
26903517-1	2016	DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically generate histone Lys-63-linked ubiquitin chains in DSB signaling.	Lysine	193-196	ring finger protein 168	Homo sapiens	110-116
28606761-1	2017	Bromodomain-containing protein 9 (BRD9), an epigenetic "reader" of acetylated lysines on post-translationally modified histone proteins, is upregulated in multiple cancer cell lines.	Lysine	78-85	bromodomain containing 9	Homo sapiens	34-38
23827745-1	2013	The lysine connection with phosphatidylglycerol (PG) alters the M. tuberculosis(Mtb) surface charge, and consequently it may decrease the bacterial vulnerability to antimicrobial action of the immune cells.	Lysine	4-10	metallothionein 1J, pseudogene	Homo sapiens	80-83
28483947-6	2017	Genetic and pharmacologic approaches were employed to identify a specific role for G9a, a histone methyltransferase (HMT), in promoting methylation of histone H3 lysine-9 (H3K9) mono- and dimethylation, and surprisingly trimethylation, at the USP37 promoter to repress its gene expression.	Lysine	162-168	PR/SET domain 9	Homo sapiens	90-115
23585136-11	2013	These findings suggest that CGRP-induced positive-inotropic effects may be increased by treatments with estradiol and progesterone and inhibited by LY.	Lysine	148-150	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
26961877-3	2016	Inclusion of exon 16 introduces a pair of Lys residues, providing a site for controlled endoproteolytic cleavage of PAM and the separation of soluble peptidylglycine alpha-hydroxylating monooxygenase from membrane-associated PAL.	Lysine	42-45	peptidylglycine alpha-amidating monooxygenase	Mus musculus	116-119
26988914-3	2016	In this study, we demonstrate in vitro and in vivo automethylation of SUV39H2 at lysine 392.	Lysine	81-87	SUV39H2 histone lysine methyltransferase	Homo sapiens	70-77
26988914-6	2016	Our finding unveils a novel autoregulatory mechanism of SUV39H2 through lysine automethylation.	Lysine	72-78	SUV39H2 histone lysine methyltransferase	Homo sapiens	56-63
26903513-0	2016	Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination.	Lysine	159-165	cancer/testis antigen 1A	Homo sapiens	65-73
26903513-3	2016	Here we identified the unique lysine residue at position 124 of the NY-ESO-1 cancer/testis antigen as the acceptor site for the formation of canonical Lys-48-linkages.	Lysine	30-36	cancer/testis antigen 1A	Homo sapiens	68-76
28483947-6	2017	Genetic and pharmacologic approaches were employed to identify a specific role for G9a, a histone methyltransferase (HMT), in promoting methylation of histone H3 lysine-9 (H3K9) mono- and dimethylation, and surprisingly trimethylation, at the USP37 promoter to repress its gene expression.	Lysine	162-168	PR/SET domain 9	Homo sapiens	117-120
23772552-3	2013	In an effort to identify inhibitors of ubiquitin carrier protein 9 (Ubc9)-dependent sumoylation, a high-throughput fluorescence polarization assay was developed, which allows detection of Lys-1201 sumoylation, corresponding to the major site of functional sumoylation within the transcriptional repressor trichorhino-phalangeal syndrome type I protein (TRPS1).	Lysine	188-191	ubiquitin conjugating enzyme E2 I	Homo sapiens	39-66
23772552-3	2013	In an effort to identify inhibitors of ubiquitin carrier protein 9 (Ubc9)-dependent sumoylation, a high-throughput fluorescence polarization assay was developed, which allows detection of Lys-1201 sumoylation, corresponding to the major site of functional sumoylation within the transcriptional repressor trichorhino-phalangeal syndrome type I protein (TRPS1).	Lysine	188-191	ubiquitin conjugating enzyme E2 I	Homo sapiens	68-72
28654864-1	2017	Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a histone 3 lysine 36 (H3K36) specific methyltransferase that is frequently deleted in Wolf-Hirschhorn syndrome (WHS).	Lysine	60-66	nuclear receptor binding SET domain protein 2	Danio rerio	0-36
23388389-2	2013	Intramolecular allosteric interactions in the phospholipase C (PLC)-delta1 pleckstrin homology (PH) domain were investigated by solution NMR spectroscopy for selectively [alpha-(15)N]Lys-labeled proteins.	Lysine	183-186	phospholipase C delta 1	Homo sapiens	46-74
26903513-3	2016	Here we identified the unique lysine residue at position 124 of the NY-ESO-1 cancer/testis antigen as the acceptor site for the formation of canonical Lys-48-linkages.	Lysine	151-154	cancer/testis antigen 1A	Homo sapiens	68-76
26903513-4	2016	Interestingly, a lysine-less form of NY-ESO-1 was as efficient as its wild-type counterpart in supplying the HLA-A*0201-restricted NY-ESO-1157-165 antigenic peptide.	Lysine	17-23	cancer/testis antigen 1A	Homo sapiens	37-45
26903513-5	2016	In fact, we show that the regulation of NY-ESO-1 processing by the ubiquitin receptors Rpn10 and Rpn13 as a well as by the standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites.	Lysine	204-210	cancer/testis antigen 1A	Homo sapiens	40-48
23395854-1	2013	In cells starved for leucine, lysine or glutamine heat shock factor 1 (HSF1) is inactivated and the level of the transcripts of the HSF1 target genes HSPA1A (Hsp70) and DNAJB1 (Hsp40) drops.	Lysine	30-36	heat shock transcription factor 1	Homo sapiens	71-75
28654864-1	2017	Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a histone 3 lysine 36 (H3K36) specific methyltransferase that is frequently deleted in Wolf-Hirschhorn syndrome (WHS).	Lysine	60-66	nuclear receptor binding SET domain protein 2	Danio rerio	38-43
28978134-4	2017	SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1).	Lysine	32-38	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
23547809-5	2013	In fact, Tat blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of nuclear factor- kappaB (NF- kappaB) by interacting with the deacetylase domain of SIRT1.	Lysine	56-62	tyrosine aminotransferase	Homo sapiens	9-12
26654953-6	2016	At the same time, the acetylation levels of the lysines 5 and 12 of histone H4 were upregulated after overexpression with HAT1.	Lysine	48-55	histone acetyltransferase 1	Homo sapiens	122-126
28978134-4	2017	SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1).	Lysine	32-38	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	97-123
27046229-3	2016	Here we analyzed the EGCG-derived intermediates generated upon incubation with the human serum albumin (HSA) and established that EGCG selectively oxidized the lysine residues via its oxidative deamination activity.	Lysine	160-166	albumin	Mus musculus	89-102
28978134-4	2017	SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1).	Lysine	32-38	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	125-129
28640323-3	2017	Based on previous work by us and others, we generated TAFI variants with one or more of residues Lys 42, Lys 43, Lys 44 and Arg 12 within the activation peptide mutated to alanine.	Lysine	97-100	carboxypeptidase B2	Homo sapiens	54-58
23615279-6	2013	Differentiating neurons generated from Rb(-/-); p107(-/-); p130(-/-) (Rb-TKO) progenitors, but not acutely inactivated Rb-TKO differentiating neurons, activated the DNA double-strand break (DSB) repair pathway without increasing trimethylation at lysine 20 of histone H4 (H4K20), which has a role in protection against DNA damage.	Lysine	247-253	RB transcriptional corepressor like 1	Mus musculus	48-52
28640323-3	2017	Based on previous work by us and others, we generated TAFI variants with one or more of residues Lys 42, Lys 43, Lys 44 and Arg 12 within the activation peptide mutated to alanine.	Lysine	105-108	carboxypeptidase B2	Homo sapiens	54-58
26645727-2	2016	Mutations in EED and SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent aberrant transcriptional activation of polycomb repressive complex 2-repressed homeobox master regulators.	Lysine	60-66	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	21-26
28640323-3	2017	Based on previous work by us and others, we generated TAFI variants with one or more of residues Lys 42, Lys 43, Lys 44 and Arg 12 within the activation peptide mutated to alanine.	Lysine	105-108	carboxypeptidase B2	Homo sapiens	54-58
28640323-4	2017	Mutation of one, two, or three Lys residues or the Arg residue alone decreased the catalytic efficiency of TAFI activation by thrombin-TM by 2.4-, 3.2-, 4.7-, and 15.0-fold, respectively, and increased the TAFI concentrations required for half-maximal prolongation of clot lysis times (K1/2) by 3-, 4,- 15-, and 24-fold, respectively.	Lysine	31-34	carboxypeptidase B2	Homo sapiens	107-111
28640323-4	2017	Mutation of one, two, or three Lys residues or the Arg residue alone decreased the catalytic efficiency of TAFI activation by thrombin-TM by 2.4-, 3.2-, 4.7-, and 15.0-fold, respectively, and increased the TAFI concentrations required for half-maximal prolongation of clot lysis times (K1/2) by 3-, 4,- 15-, and 24-fold, respectively.	Lysine	31-34	carboxypeptidase B2	Homo sapiens	206-210
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	11-14	carboxypeptidase B2	Homo sapiens	81-85
26542424-3	2016	BAZ1A contains one C-terminal bromodomain, which specifically recognizes acetylation of lysine.	Lysine	88-94	bromodomain adjacent to zinc finger domain 1A	Mus musculus	0-5
23620257-3	2013	PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histone H3 lysine 27 trimethylation (H3K27me3) modification for repression.	Lysine	130-136	protein regulator of cytokinesis 1	Homo sapiens	58-62
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	19-22	carboxypeptidase B2	Homo sapiens	81-85
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Lysine	19-22	carboxypeptidase B2	Homo sapiens	81-85
23466492-6	2013	Interestingly, the carboxyl terminus of alpha-actinin-4 including its calcium binding motifs, is inhibitory for a secondary cleavage of alpha-actinin-4 between lysine 283 and valine 284.	Lysine	160-166	actinin alpha 4	Homo sapiens	40-55
29050267-6	2017	Either depletion of PIAS4 or overexpression of SENP2 eliminated SUMOylation of ORC2 at the G/M phase and consequently resulted in abnormal centromeric histone H3 lysine 4 methylation.	Lysine	162-168	SUMO specific peptidase 2	Homo sapiens	47-52
23466492-6	2013	Interestingly, the carboxyl terminus of alpha-actinin-4 including its calcium binding motifs, is inhibitory for a secondary cleavage of alpha-actinin-4 between lysine 283 and valine 284.	Lysine	160-166	actinin alpha 4	Homo sapiens	136-151
23754951-1	2013	Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly.	Lysine	183-190	histone aminotransferase 1	Mus musculus	0-27
23754951-9	2013	Analysis of histone dynamics at sites of replication-coupled chromatin assembly demonstrates that Hat1 is not only responsible for the acetylation of newly synthesized histone H4 but is also required to maintain the acetylation of histone H3 on lysines 9, 18, and 27 during replication-coupled chromatin assembly.	Lysine	245-252	histone aminotransferase 1	Mus musculus	98-102
27012465-4	2016	Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8).	Lysine	40-43	NEDD8 ubiquitin like modifier	Homo sapiens	114-119
28673974-4	2017	We found that PALB2 associates with active genes through its major binding partner, MRG15, which recognizes histone H3 trimethylated at lysine 36 (H3K36me3) by the SETD2 methyltransferase.	Lysine	136-142	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	164-169
26859163-3	2016	The results showed that the expression levels of histone deacetylase 1 (HDAC1), histone deacetylase 3 (HDAC3), and thymic stromal lymphopoietin (TSLP) were significantly upregulated in mice with allergic rhinitis, whereas H3 acetylation at lysine 9 (H3AcK9) was decreased.	Lysine	240-246	thymic stromal lymphopoietin	Mus musculus	145-149
28661476-4	2017	XIAP binds to Cdc42 and directly conjugates poly ubiquitin chains to the Lysine 166 of Cdc42 targeting it for proteasomal degradation.	Lysine	73-79	X-linked inhibitor of apoptosis	Mus musculus	0-4
26743126-11	2016	Furthermore, we have identified a lysine degradation pathway as a common regulatory pathway for miR-1260a, miR-1260b, and miR-3182 by using DIANA-mirPath.	Lysine	34-40	microRNA 1260a	Homo sapiens	96-105
23699411-5	2013	The complex is anchored via binding of HP1gamma to H3K9me3 (histone H3 tails trimethylated on Lys 9).	Lysine	94-97	chromobox 3	Homo sapiens	39-47
28661476-4	2017	XIAP binds to Cdc42 and directly conjugates poly ubiquitin chains to the Lysine 166 of Cdc42 targeting it for proteasomal degradation.	Lysine	73-79	cell division cycle 42	Mus musculus	14-19
23430617-6	2013	Further, angiotensin II, a major hormonal inducer of vascular senescence, induces prolonged lysine acetylation of PGC-1alpha and releases the PGC-1alpha-FoxO1 complex from the SIRT1 promoter, thus reducing SIRT1 expression.	Lysine	92-98	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	114-124
26865629-5	2016	Moreover, the results of Ala-scanning mutagenesis of hNPS-(1-13) indicated that residues Lys(11)and Lys(12)are structurally crucial for the hNPS receptor to couple to Galphas-dependent signaling.	Lysine	89-92	neuropeptide S	Homo sapiens	53-57
28661476-4	2017	XIAP binds to Cdc42 and directly conjugates poly ubiquitin chains to the Lysine 166 of Cdc42 targeting it for proteasomal degradation.	Lysine	73-79	cell division cycle 42	Mus musculus	87-92
26865629-5	2016	Moreover, the results of Ala-scanning mutagenesis of hNPS-(1-13) indicated that residues Lys(11)and Lys(12)are structurally crucial for the hNPS receptor to couple to Galphas-dependent signaling.	Lysine	89-92	neuropeptide S	Homo sapiens	140-144
28458255-4	2017	SIRT5 largely reversed the succinyl-CoA-driven lysine succinylation.	Lysine	47-53	sirtuin 5	Homo sapiens	0-5
26865629-5	2016	Moreover, the results of Ala-scanning mutagenesis of hNPS-(1-13) indicated that residues Lys(11)and Lys(12)are structurally crucial for the hNPS receptor to couple to Galphas-dependent signaling.	Lysine	100-103	neuropeptide S	Homo sapiens	53-57
26865629-5	2016	Moreover, the results of Ala-scanning mutagenesis of hNPS-(1-13) indicated that residues Lys(11)and Lys(12)are structurally crucial for the hNPS receptor to couple to Galphas-dependent signaling.	Lysine	100-103	neuropeptide S	Homo sapiens	140-144
27462448-7	2016	USP9x acts to deubiquitylate Angiomotin at lysine 496, resulting in stabilization of Angiomotin and lower YAP/TAZ activity.	Lysine	43-49	Yes1 associated transcriptional regulator	Homo sapiens	106-109
23624957-1	2013	Holocarboxylase synthetase (HLCS) is a chromatin protein that facilitates the creation of histone H3 lysine 9-methylation (H3K9me) gene repression marks through physical interactions with the histone methyltransferase EHMT-1.	Lysine	101-107	holocarboxylase synthetase	Homo sapiens	0-26
23624957-1	2013	Holocarboxylase synthetase (HLCS) is a chromatin protein that facilitates the creation of histone H3 lysine 9-methylation (H3K9me) gene repression marks through physical interactions with the histone methyltransferase EHMT-1.	Lysine	101-107	holocarboxylase synthetase	Homo sapiens	28-32
28458255-10	2017	Three-dimensional modeling of Complex II suggested that several SIRT5-targeted lysine residues lie at the protein-lipid interface of succinate dehydrogenase subunit B.	Lysine	79-85	sirtuin 5	Homo sapiens	64-69
23487450-6	2013	The greatest increase in Tat activity was seen with the Gln(35)/Lys(39) double mutant that resulted in an additional 49% (+- 14%) production of LTR-driven luciferase (P = 0.012).	Lysine	64-67	tyrosine aminotransferase	Homo sapiens	25-28
28465486-4	2017	Here we show that SphK2 overexpression contributes to the resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid degradation of cytoplasmic retinoid X receptor alpha (RXRalpha) by lysine 48 (K48)- and lysine 63 (K63)-based polyubiquitination.	Lysine	208-214	sphingosine kinase 2	Homo sapiens	18-23
23462506-1	2013	Base amino acid lysine residues play an important role in regulation of nuclear receptors [e.g., farnesyl X receptor (FXR)], leading to enhanced or suppressed biologic activity.	Lysine	16-22	nuclear receptor subfamily 1 group H member 4	Homo sapiens	118-121
23462506-2	2013	To understand the molecular mechanisms and the subsequent effects in modulating FXR functions in diverse biologic processes, we individually replaced eight highly conserved lysine residues of human FXR (hFXR) with arginine.	Lysine	173-179	nuclear receptor subfamily 1 group H member 4	Homo sapiens	198-201
23462506-2	2013	To understand the molecular mechanisms and the subsequent effects in modulating FXR functions in diverse biologic processes, we individually replaced eight highly conserved lysine residues of human FXR (hFXR) with arginine.	Lysine	173-179	nuclear receptor subfamily 1 group H member 4	Homo sapiens	203-207
23462506-10	2013	In conclusion, four highly conserved lysine residues of hFXR, K122, K210, K339, and K460, have been identified that play a critical role in FXR target gene regulation and molecular interaction (protein-protein and protein-DNA).	Lysine	37-43	nuclear receptor subfamily 1 group H member 4	Homo sapiens	56-60
23462506-10	2013	In conclusion, four highly conserved lysine residues of hFXR, K122, K210, K339, and K460, have been identified that play a critical role in FXR target gene regulation and molecular interaction (protein-protein and protein-DNA).	Lysine	37-43	nuclear receptor subfamily 1 group H member 4	Homo sapiens	57-60
26073078-1	2016	Mutations in SETD2, a histone H3 lysine trimethyltransferase, have been identified in clear cell renal cell carcinoma (ccRCC); however it is unclear if loss of SETD2 function alters the genomic distribution of histone 3 lysine 36 trimethylation (H3K36me3) in ccRCC.	Lysine	33-39	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	13-18
26776670-3	2016	AhR-G1661A single nucleotide polymorphism (SNP: rs2066853) causes an arginine to lysine substitution in the acidic sub-domain of TAD at position 554 (R554K).	Lysine	81-87	aryl hydrocarbon receptor	Homo sapiens	0-3
26961893-4	2016	Furthermore, to identify the site at which Tssk4 phosphorylates Odf2, we generated several Odf2 point mutants (Ser/Thr/Lys to Ala) and identified serine 76 of Odf2 as one of the phosphorylation sites.	Lysine	119-122	testis-specific serine kinase 4	Mus musculus	43-48
28465486-4	2017	Here we show that SphK2 overexpression contributes to the resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid degradation of cytoplasmic retinoid X receptor alpha (RXRalpha) by lysine 48 (K48)- and lysine 63 (K63)-based polyubiquitination.	Lysine	229-235	sphingosine kinase 2	Homo sapiens	18-23
23552949-3	2013	Here we show that human SIRT6 efficiently removes long-chain fatty acyl groups, such as myristoyl, from lysine residues.	Lysine	104-110	sirtuin 6	Homo sapiens	24-29
23552949-8	2013	The discovery of SIRT6 as an enzyme that controls protein lysine fatty acylation provides new opportunities to investigate the physiological function of a protein post-translational modification that has been little studied until now.	Lysine	58-64	sirtuin 6	Homo sapiens	17-22
28596365-3	2017	PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide.	Lysine	169-175	protein regulator of cytokinesis 1	Homo sapiens	8-12
23322406-7	2013	Subsequently, the ubiquitination of CARMA1 catalyzed by STUB1 was identified as Lys-27 linked, which is important for CARMA1-mediated NF-kappaB activation.	Lysine	80-83	STIP1 homology and U-box containing protein 1	Homo sapiens	56-61
26554858-4	2016	For the recognition of asparagine and lysine, asparaginyl-tRNA synthetase and lysyl-tRNA synthase were immobilized onto microparticles, respectively, and coupled with coloration reagents for spectrophotometric detection.	Lysine	38-44	asparaginyl-tRNA synthetase 1	Homo sapiens	46-73
28596365-3	2017	PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide.	Lysine	169-175	protein regulator of cytokinesis 1	Homo sapiens	94-98
23460739-8	2013	Accordingly, the mutation of an MBL conserved lysine residue essential for MASP binding (K55) abolished binding to soluble CR1 and CCP22-30.	Lysine	46-52	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	123-126
23460739-8	2013	Accordingly, the mutation of an MBL conserved lysine residue essential for MASP binding (K55) abolished binding to soluble CR1 and CCP22-30.	Lysine	46-52	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	Homo sapiens	131-136
26787453-11	2016	In conclusion, our results indicate that Nepsilon-lysine acetylation in the endoplasmic reticulum lumen regulates normal proteostasis of the secretory pathway; they also support therapies targeting endoplasmic reticulum acetyltransferases, ATase1 and ATase2, for a subset of chronic degenerative diseases.	Lysine	50-56	N-acetyltransferase 8 (GCN5-related)	Mus musculus	251-257
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	RELA proto-oncogene, NF-kB subunit	Homo sapiens	19-22
26694085-3	2016	EZH2 is a histone methyltransferase that acts as the catalytic agent of the polycomb-repressive complex 2 (PRC2) to maintain gene repression via methylation of lysine 27 on histone H3 (H3K27).	Lysine	160-166	PR/SET domain 9	Homo sapiens	10-35
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	E1A binding protein p300	Homo sapiens	83-87
23455478-5	2013	CUL3-KLHL22 ubiquitylates Lys 492, located within the PBD, leading to PLK1 dissociation from kinetochore phosphoreceptors.	Lysine	26-29	cullin 3	Homo sapiens	0-4
23455478-5	2013	CUL3-KLHL22 ubiquitylates Lys 492, located within the PBD, leading to PLK1 dissociation from kinetochore phosphoreceptors.	Lysine	26-29	kelch like family member 22	Homo sapiens	5-11
28416608-8	2017	O-GlcNAcylation of p65 at Thr-305 and Ser-319 increased CREB-binding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.	Lysine	131-134	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
26685127-3	2016	We report a surprisingly uniform pattern of primarily monomethylation on lysine 20 of histone H4 present in short polynucleosomes mixtures of CENP-A and H3 nucleosomes isolated from functional centromeres.	Lysine	73-79	centromere protein A	Homo sapiens	142-148
28458162-2	2017	PCNA can be monoubiquitylated at lysine 164 by the RAD6-RAD18 ubiquitin ligase complex.	Lysine	33-39	RAD18, E3 ubiquitin protein ligase	Gallus gallus	56-61
26911616-6	2016	Complement sequencing subsequently revealed a potential causative mutation in exon 12 of complement factor B with changes of lysine at amino acid position 533 to an arginine (CFB p.K533R).	Lysine	125-131	complement factor B	Homo sapiens	89-108
23365460-3	2013	Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX (Kdm6a) as a novel regulator for hematopoietic cell migration.	Lysine	134-140	chemokine (C-X-C motif) ligand 12	Mus musculus	41-70
23365460-3	2013	Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX (Kdm6a) as a novel regulator for hematopoietic cell migration.	Lysine	134-140	chemokine (C-X-C motif) ligand 12	Mus musculus	72-77
28229514-5	2017	In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased trimethylation of lysine 27 of histone H3.	Lysine	129-135	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	70-75
26403849-3	2016	It was found that the recombinant, purified mitochondrial solute carrier SLC25A2 when reconstituted into liposomes efficiently transports ADMA in addition to its known substrates arginine, lysine, and ornithine and in contrast to the other known mitochondrial amino acid transporters SLC25A12, SLC25A13, SLC25A15, SLC25A18, SLC25A22, and SLC25A29.	Lysine	189-195	solute carrier family 25 member 2	Homo sapiens	73-80
26450989-6	2016	Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFbeta treatment.	Lysine	55-61	small ubiquitin like modifier 1	Homo sapiens	100-131
26450989-6	2016	Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFbeta treatment.	Lysine	55-61	small ubiquitin like modifier 1	Homo sapiens	133-138
22614015-5	2013	Furthermore, HACE1 catalyses the poly-ubiquitylation of Rac1 at lysine 147 following its activation by HGF, resulting in its proteasomal degradation.	Lysine	64-70	hepatocyte growth factor	Homo sapiens	103-106
28201649-3	2017	We identify a non-canonical SUMOylation motif termed pSuM that conjugates SUMO2 at Lys-325 of FXR under the direct control of casein kinase 2 (CK2), which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327.	Lysine	83-86	nuclear receptor subfamily 1 group H member 4	Homo sapiens	94-97
23534949-10	2013	Aberrant histone 3 lysine 27 trimethylation (H3K27me3) by mutant HMTases or UTX induces overexpression of the homeobox A9 (HOXA9) gene.	Lysine	19-25	homeobox A9	Homo sapiens	110-121
23534949-10	2013	Aberrant histone 3 lysine 27 trimethylation (H3K27me3) by mutant HMTases or UTX induces overexpression of the homeobox A9 (HOXA9) gene.	Lysine	19-25	homeobox A9	Homo sapiens	123-128
23322770-4	2013	Here we report a dynamic, post-translational regulation of its kinase activity that is coordinated by an acetylation-deacetylation switch, p300/CBP-mediated Lys-53 acetylation inhibits SIK2 kinase activity, whereas HDAC6-mediated deacetylation restores the activity.	Lysine	157-160	E1A binding protein p300	Homo sapiens	139-143
28201649-3	2017	We identify a non-canonical SUMOylation motif termed pSuM that conjugates SUMO2 at Lys-325 of FXR under the direct control of casein kinase 2 (CK2), which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327.	Lysine	83-86	ubiquitin conjugating enzyme E2 I	Homo sapiens	197-201
26998524-6	2016	An acetyl-mimetic mutation targeting an SDHA lysine residue shown to be hyperacetylated in the failing human heart reduced catalytic function and reduced complex II-driven respiration.	Lysine	45-51	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	40-44
28201649-4	2017	Lys-325 SUMOylation is indispensable to the promotion of efficient ligand activation and transcriptional coactivation of FXR.	Lysine	0-3	nuclear receptor subfamily 1 group H member 4	Homo sapiens	121-124
28302719-5	2017	As a result of inactivation of the pRB-E2F1-EZH2 pathway, the repressive marker trimethylation of histone H3 lysine 27 at the 11beta-HSD2 promoter is removed, which leads to the robust expression of 11beta-HSD2 during syncytialization.	Lysine	109-115	RB transcriptional corepressor 1	Homo sapiens	35-38
26581161-5	2016	On the other hand, the pRB1-SET1A complex may carry methyls(me) to occupy the position of H3K4, resulting in specific tri-methylation of forth lysine of histone H3 (H3K4me3).	Lysine	143-149	proline rich protein BstNI subfamily 1	Homo sapiens	23-27
23575530-1	2013	PR-SET7 (also named SET8 or KMT5a) is a sole lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	0-7
23575530-1	2013	PR-SET7 (also named SET8 or KMT5a) is a sole lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	20-24
23575530-1	2013	PR-SET7 (also named SET8 or KMT5a) is a sole lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	28-33
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	104-110	E1A binding protein p300	Homo sapiens	251-255
26822058-5	2016	A site-directed mutagenesis approach revealed that lysine residues at positions 217 and 252 within the extracellular loop of tricellulin play important roles in PLG-binding activity.	Lysine	51-57	plasminogen	Homo sapiens	161-164
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	194-200	E1A binding protein p300	Homo sapiens	251-255
26549688-11	2016	Substitution of all its four putative lysine residues along with NDSM abolished the effect of SUMO-1-mediated transactivation function of PXR.	Lysine	38-44	small ubiquitin like modifier 1	Homo sapiens	94-100
23302691-6	2013	H1 also interferes with binding of the SET7/9 histone methyltransferase to the imprinting control regions, inhibiting production of an activating methylation mark on histone H3 lysine 4.	Lysine	177-183	SET domain containing (lysine methyltransferase) 7	Mus musculus	39-45
28338656-5	2017	Among these genes, we showed that FAK silencing decreased transcription and nuclear localization of enhancer of zeste homolog 2 (EZH2) and its tri-methylation activity on lysine 27 of histone H3 (H3K27me3).	Lysine	171-177	protein tyrosine kinase 2	Homo sapiens	34-37
23256819-5	2013	Thus, while the modification of proteins or peptides in solution takes several days to lead to a significant amount of modification, in RHE the modifications of nucleophilic amino acids were observable already at 24 h. The chemioselectivity also appeared to be different with major modifications taking place on histidine, methionine, and cysteine residues in RHE, while on HSA, significant modifications were observed on lysine residues with the formation of methylated and dimethylated amino groups.	Lysine	422-428	factor interacting with PAPOLA and CPSF1	Homo sapiens	136-139
26761793-10	2016	We determined that the effects of APE1 were mediated through its N-terminal lysine residues interacting with Rac1, leading to inhibition of Nox1 expression and ROS generation.	Lysine	76-82	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	34-38
28130569-8	2017	It also mitigated the trimethylation of histone 3 at lysine 27 (H3K27me3), which reduced H3K27me3 enrichment to Dkk1 promoter and thereby lowered Dkk1 transcription.	Lysine	53-59	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	112-116
26719415-4	2016	Deubiquitinase CYLD negatively regulates MyD88-mediated signaling by directly interacting with MyD88 and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 at lysine 231.	Lysine	214-220	CYLD lysine 63 deubiquitinase	Mus musculus	15-19
26264666-2	2016	We report a novel design for a fluorescent, DNA-binding protein (FP-DBP) that completely "paints" entire DNA molecules, whereby sequence-independent DNA binding is accomplished by linking a fluorescent protein to two small peptides (KWKWKKA) using lysine for binding to the DNA phosphates, and tryptophan for intercalating between DNA bases.	Lysine	248-254	zinc finger protein 763	Homo sapiens	44-63
23230144-5	2013	Generation of 4ICD by NRG-1 leads to increased levels of trimethylated histone H3 on lysine 9 (H3K9me3) in a manner dependent on the nuclear accumulation of 4ICD and its tyrosine kinase activity.	Lysine	85-91	neuregulin 1	Homo sapiens	22-27
23168412-0	2013	Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIII.	Lysine	30-33	coagulation factor VIII	Homo sapiens	106-129
23168412-5	2013	However, Lys-773 of peptide Ser-766-Leu-774 was protected from chemical modification in the presence of FVIII.	Lysine	9-12	coagulation factor VIII	Homo sapiens	104-109
28130569-8	2017	It also mitigated the trimethylation of histone 3 at lysine 27 (H3K27me3), which reduced H3K27me3 enrichment to Dkk1 promoter and thereby lowered Dkk1 transcription.	Lysine	53-59	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	146-150
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	phosphoglycerate dehydrogenase	Sus scrofa	358-363
24289579-10	2013	Methylation of HMGB1 at lysine 112 in ccRCC was detected by MS. Bioinformatics analysis showed that post-translational modification might affect the binding ability to DNA and mediate its translocation.	Lysine	24-30	high mobility group box 1	Homo sapiens	15-20
24289579-12	2013	Methylation of HMGB1 at lysine 112 might the redistribution of this cofactor protein.	Lysine	24-30	high mobility group box 1	Homo sapiens	15-20
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	cell death inducing DFFA like effector c	Sus scrofa	451-456
28119421-6	2017	Lysines within the lyase domain are required for processive searching, revealing a novel function for the lyase domain of Pol beta.	Lysine	0-7	DNA polymerase beta	Homo sapiens	122-130
22868271-4	2013	recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.	Lysine	103-109	developmental pluripotency associated 3	Homo sapiens	58-64
22868271-4	2013	recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.	Lysine	103-109	developmental pluripotency associated 3	Homo sapiens	65-70
26837744-1	2016	SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine residues of proteins.	Lysine	189-195	small ubiquitin like modifier 1	Homo sapiens	161-166
28158503-5	2017	WRN responds to site-specific telomeric damage via its RQC domain, interacting at Lysine 1016 and Phenylalanine1037 with the N-terminal acidic domain of the telomere shelterin protein TRF1 and demonstrating a novel mechanism for WRN"s role in telomere protection.	Lysine	82-88	WRN RecQ like helicase	Homo sapiens	0-3
26497278-5	2016	METHODS: Four A1M-variants were expressed: with cysteine to serine substitution in position 34, lysine to threonine substitutions in positions (92, 118, 130), histidine to serine substitution in position 123 and a wt without mutations.	Lysine	96-102	alpha-1-microglobulin/bikunin precursor	Homo sapiens	14-17
23235109-6	2013	DNA methylation in the NKG2D gene was observed in CD4(+) T lymphocytes and T cell lines (Jurkat and HUT78), while this gene was unmethylated in NKG2D-positive cells (CD8(+) T lymphocytes, NK cells and NKL cell line) and associated with high levels of histone H3 lysine 9 acetylation (H3K9Ac).	Lysine	262-268	killer cell lectin like receptor K1	Homo sapiens	23-28
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 7	Homo sapiens	38-42
28406455-6	2017	The homology model of the PR1 structure shows that the cluster of positively charged amino acid residues (arginines 60, 67, 137, and lysine 135) could indeed interact with negatively charged phospholipids of cellular membranes.	Lysine	133-139	pathogenesis-related protein 1	Arabidopsis thaliana	26-29
23362207-3	2013	Furthermore, we found that mutations in HDA19 resulted in the ectopic expression of seed maturation genes in seedlings, which was associated with increased levels of gene activation marks, such as Histone H3 acetylation (H3ac), Histone H4 acetylation (H4ac), and Histone H3 Lys 4 tri-methylation (H3K4me3), but decreased levels of the gene repression mark Histone H3 Lys 27 tri-methylation (H3K27me3) in the promoter and/or coding regions.	Lysine	274-277	histone deacetylase 1	Arabidopsis thaliana	40-45
26867736-0	2016	Quantitative Analysis of the Sirt5-Regulated Lysine Succinylation Proteome in Mammalian Cells.	Lysine	45-51	sirtuin 5	Homo sapiens	29-34
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	deltex 2, E3 ubiquitin ligase	Mus musculus	85-92
26516698-1	2016	Sequencing of clear cell renal cell carcinomas identified loss-of-function mutations of SETD2, a gene that encodes a nonredundant methytransferase responsible for histone H3 lysine 36 trimethylation (H3K36me3), and H3K36me3 is progressively deregulated in metastases.	Lysine	174-180	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	88-93
23362207-3	2013	Furthermore, we found that mutations in HDA19 resulted in the ectopic expression of seed maturation genes in seedlings, which was associated with increased levels of gene activation marks, such as Histone H3 acetylation (H3ac), Histone H4 acetylation (H4ac), and Histone H3 Lys 4 tri-methylation (H3K4me3), but decreased levels of the gene repression mark Histone H3 Lys 27 tri-methylation (H3K27me3) in the promoter and/or coding regions.	Lysine	367-370	histone deacetylase 1	Arabidopsis thaliana	40-45
23349634-6	2013	Based on the spectral data, we were able to identify methylation sites in substrates, notably trimethylation of K135 of KIN/Kin17, K561 of HSPA8/Hsc70 as well as corresponding lysine residues in other Hsp70 isoforms, and K315 of VCP/p97.	Lysine	176-182	valosin containing protein	Homo sapiens	229-236
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	deltex 2, E3 ubiquitin ligase	Mus musculus	85-92
23349634-10	2013	Lysine 315 falls in proximity to the Walker B motif of VCP"s first ATPase/D1 domain.	Lysine	0-6	valosin containing protein	Homo sapiens	55-58
26304540-0	2015	Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.	Lysine	53-59	histocompatibility 33	Mus musculus	16-20
26319015-5	2015	We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity.	Lysine	63-70	SUMO ligase NFI1	Saccharomyces cerevisiae S288C	12-16
28180293-1	2017	Rad6 and Bre1, ubiquitin-conjugating E2 and E3 enzymes respectively, are responsible for histone H2B lysine 123 mono-ubiquitination (H2Bub1) in Saccharomyces cerevisiae.	Lysine	101-107	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	9-13
26319017-5	2015	HP1gamma, but not HP1alpha, was strongly enhanced in selective binding to tri-methylated lysine 9 in histone H3 by the addition of Mg(2+) or linker histone H1, which are known to induce compaction of nucleosomes.	Lysine	89-95	chromobox 3	Homo sapiens	0-8
26319017-6	2015	We propose that this novel property of HP1gamma recognition of lysine 9 in the histone H3 tail in different nucleosome structures plays a role in reading the histone code.	Lysine	63-69	chromobox 3	Homo sapiens	39-47
23555788-9	2013	These data suggest that Ps-1 protein facilitates PROP bitter taste perception and identifies a role for free L-Arg and L-Lys in PROP tasting.	Lysine	119-124	taste 2 receptor member 62 pseudogene	Homo sapiens	24-28
23484054-0	2013	Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.	Lysine	127-133	solute carrier family 6 member 5	Homo sapiens	74-79
23484054-6	2013	Here, we show that ubiquitination of a C-terminus four lysine cluster of GlyT2 is required for constitutive endocytosis, sorting into the slow recycling pathway and turnover of the transporter.	Lysine	55-61	solute carrier family 6 member 5	Homo sapiens	73-78
28380357-3	2017	In the present study, we find that Keap1/Cullin3 ubiquitinates p62 at lysine 420 within its UBA domain.	Lysine	70-76	cullin 3	Homo sapiens	41-48
28150854-1	2017	Using intravital confocal microscopy, we observed previously that the process of platelet phosphatidylserine (PS) exposure, fibrin formation and lysine binding site-dependent plasminogen (plg) accumulation took place only in the centre of thrombi, not at their periphery.	Lysine	145-151	plasminogen	Homo sapiens	188-191
23326327-8	2013	Using additional recombinant apolipoprotein(a) (r-apo(a)) variants, we demonstrated that this effect was dependent on the presence of an intact lysine-binding site in kringle V domain of apo(a), but not on the presence of the functional lysine-binding site in apo(a) kringle IV type 10; sequences within in the amino-terminal half of the molecule were also not required for the inhibitory effects of apo(a).	Lysine	144-150	lipoprotein(a)	Homo sapiens	29-46
26633535-5	2015	Through mono-ubiquitination of histone H2A at lysine 119 (H2A-K119Ub), BMI1 represses multiple gene loci; among these, the INK4A/ARF locus has been most thoroughly investigated.	Lysine	46-52	H2A clustered histone 18	Homo sapiens	39-42
26633535-5	2015	Through mono-ubiquitination of histone H2A at lysine 119 (H2A-K119Ub), BMI1 represses multiple gene loci; among these, the INK4A/ARF locus has been most thoroughly investigated.	Lysine	46-52	H2A clustered histone 18	Homo sapiens	58-61
26633535-5	2015	Through mono-ubiquitination of histone H2A at lysine 119 (H2A-K119Ub), BMI1 represses multiple gene loci; among these, the INK4A/ARF locus has been most thoroughly investigated.	Lysine	46-52	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	71-75
28089831-1	2017	SETD8 is a methyltransferase that specifically catalyzes the monomethylation of lysine 20 on histone H4.	Lysine	80-86	lysine methyltransferase 5A	Homo sapiens	0-5
26497635-2	2015	It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both di-methylation and tri-methylation of Histone H3 at lysine 27 (H3K27me2/3).	Lysine	150-156	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	37-42
26497635-2	2015	It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both di-methylation and tri-methylation of Histone H3 at lysine 27 (H3K27me2/3).	Lysine	150-156	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	52-58
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	CYLD lysine 63 deubiquitinase	Mus musculus	193-197
22951141-1	2013	Suv4-20h was initially characterised as a histone methyltransferase (HMTase) that catalyses lysine 20 of histone H4 dimethylation (H4K20me2) and trimethylation (H4K20me3).	Lysine	92-98	PR/SET domain 9	Homo sapiens	42-67
26603343-8	2015	More interestingly, knocking-down of macroH2A1 resulted in the release of heterochromatin foci marked by histone lysine 9 trimethylation (H3K9me3) and the decondensation of global chromatin structure.	Lysine	113-119	macroH2A.1 histone	Mus musculus	37-46
28260048-7	2017	In turn, the interaction between ZAC and P300 increased the activity of P300-HAT; ultimately, the phosphorylation of serine 10 in histone H3 (pS10-H3) was decreased and the acetylation of lysine 14 in histone H3 (acK14-H3) was increased.	Lysine	188-194	E1A binding protein p300	Homo sapiens	41-45
26604986-6	2015	In addition, we find that the strongest CBP sites in the genome are found at Polycomb response elements embedded in histone H3 lysine 27 trimethylated (H3K27me3) chromatin, where they correlate with binding of the Pho repressive complex.	Lysine	127-133	Polycomb	Drosophila melanogaster	77-85
22951141-1	2013	Suv4-20h was initially characterised as a histone methyltransferase (HMTase) that catalyses lysine 20 of histone H4 dimethylation (H4K20me2) and trimethylation (H4K20me3).	Lysine	92-98	PR/SET domain 9	Homo sapiens	69-75
26432637-1	2015	PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides and is essential for collagen pyridinoline cross-link formation.	Lysine	19-25	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-5
23086944-0	2012	Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.	Lysine	143-149	elastase, neutrophil expressed	Homo sapiens	135-138
28260048-7	2017	In turn, the interaction between ZAC and P300 increased the activity of P300-HAT; ultimately, the phosphorylation of serine 10 in histone H3 (pS10-H3) was decreased and the acetylation of lysine 14 in histone H3 (acK14-H3) was increased.	Lysine	188-194	E1A binding protein p300	Homo sapiens	72-80
23086944-9	2012	Mutation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB1 activity.	Lysine	17-23	elastase, neutrophil expressed	Homo sapiens	43-46
23086944-9	2012	Mutation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB1 activity.	Lysine	17-23	elastase, neutrophil expressed	Homo sapiens	93-96
28401060-3	2017	Lysine (K) 27 (K27) is a critical residue in all seven histone 3 variants and the subject of posttranslational histone modifications, as it can be both methylated and acetylated.	Lysine	0-6	keratin 27	Homo sapiens	15-18
23086944-10	2012	Taken together, our results suggest that adduction of LKB1 Lys-97 mediates the inhibitory effect of HNE.	Lysine	59-62	elastase, neutrophil expressed	Homo sapiens	100-103
26807165-2	2015	To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs).	Lysine	33-39	keratin 27	Homo sapiens	60-63
28423509-1	2017	Histone H3 lysine 9 dimethylation (H3K9me2) is mainly regulated by the histone lysine methyltransferase G9a and is associated with the repression of transcription.	Lysine	11-17	euchromatic histone lysine N-methyltransferase 2	Mus musculus	104-107
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Lysine	137-140	centromere protein A	Homo sapiens	81-87
22192339-1	2012	Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4.	Lysine	68-74	holocarboxylase synthetase	Homo sapiens	0-26
22192339-1	2012	Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4.	Lysine	68-74	holocarboxylase synthetase	Homo sapiens	28-31
28248093-3	2017	ALDH2 is a known target of lysine acetylation, which arises as a consequence of mitochondrial bioenergetic flux and sirtuin deacetylase activity.	Lysine	27-33	aldehyde dehydrogenase 2 family member	Homo sapiens	0-5
23016825-7	2012	By all these criteria we find that the most conserved motifs of Gpt2p and its functionally relevant lysines are oriented towards the ER lumen.	Lysine	100-107	bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2	Saccharomyces cerevisiae S288C	64-69
26505788-1	2015	Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53.	Lysine	99-105	lysine acetyltransferase 8	Homo sapiens	0-26
26505788-1	2015	Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53.	Lysine	99-105	lysine acetyltransferase 8	Homo sapiens	28-32
28248093-4	2017	The mitochondrial deacetylase Sirtuin 3 (SIRT3) has been reported to alter ALDH2 lysine acetylation status, yet the mechanism and consequence of this interaction remain unknown.	Lysine	81-87	aldehyde dehydrogenase 2 family member	Homo sapiens	75-80
28154187-10	2017	A mass spectrometry selective reactive monitoring assay was developed and used to determine that acetylation of lysines 19 and 26 of MPC2 is enhanced in Akita heart mitochondria.	Lysine	112-119	mitochondrial pyruvate carrier 2	Mus musculus	133-137
26580594-4	2015	EZH2 (Enhancer of Zeste Homolog 2) belongs to the Polycomb repressive complex 2 as its catalytic subunit, which through the trimethylation of H3 (Histone 3) on K27 (Lysine 27), produces gene silencing.	Lysine	165-171	keratin 27	Homo sapiens	160-163
22859367-8	2012	Our results identified lysine-11 rather than the canonic lysine-48 ubiquitin chains as the degradation signal in oocytes resuming meiosis, further disclosing that CDK1 inactivation is necessary and sufficient for PBI emission.	Lysine	23-29	cyclin-dependent kinase 1	Mus musculus	163-167
28139803-1	2017	A polymeric FRET probe for the detection of MMP2 was prepared using a new N-hydroxylamine derivative of lysine (1), which was successfully incorporated into the natural peptide sequence by solid phase peptide synthesis (SPPS).	Lysine	104-110	matrix metallopeptidase 2	Homo sapiens	44-48
24900427-3	2012	We have established an assay for biochemical testing of Sirt5 using a small labeled succinylated lysine derivative.	Lysine	97-103	sirtuin 5	Homo sapiens	56-61
26549758-4	2015	Loss of Ikaros in CD4(-)CD8(-) cells leads to reduced histone H3 lysine 27 trimethylation and ectopic gene expression.	Lysine	65-71	IKAROS family zinc finger 1	Homo sapiens	8-14
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	histone deacetylase 3	Homo sapiens	0-5
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	80-85
28094437-3	2017	We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC.	Lysine	170-176	ubiquitin specific peptidase 50	Homo sapiens	53-58
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	dynein, axonemal, heavy chain 8	Mus musculus	52-58
22863104-11	2012	Plasma essential amino acids (AA), Lys, and His were lower for DMP compared with ADMP.	Lysine	35-38	serine palmitoyltransferase small subunit B	Bos taurus	81-85
28011932-1	2017	In the RV144 gp120 HIV vaccine trial, decreased transmission risk was correlated with Abs that reacted with a linear epitope at a lysine residue at position 169 (K169) in the HIV-1 envelope (Env) V2 region.	Lysine	130-136	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	191-194
22807448-7	2012	We have identified features that allow for Rnd3 turnover including a conserved Lys-45 close to the switch I region and the C-terminal membrane-binding domain of Rnd3, which cannot be substituted by the equivalent Cdc42 CAAX sequence.	Lysine	79-82	Rho family GTPase 3a	Danio rerio	43-47
26297866-10	2015	In this regard, certain lysine residues of NFAT5, when kept deacetylated, were found to contribute to its DNA binding and SIRT1 was shown to directly bind K282 of NFAT5.	Lysine	24-30	nuclear factor of activated T cells 5	Homo sapiens	43-48
26297866-10	2015	In this regard, certain lysine residues of NFAT5, when kept deacetylated, were found to contribute to its DNA binding and SIRT1 was shown to directly bind K282 of NFAT5.	Lysine	24-30	nuclear factor of activated T cells 5	Homo sapiens	163-168
27895153-6	2017	Attenuation of Ku80 ubiquitylation by replacement of ubiquitylation site lysines with arginine residues delayed Ku70/80 release from chromatin after DSB induction by genotoxic insults.	Lysine	73-80	X-ray repair cross complementing 5	Homo sapiens	15-19
30090230-0	2015	Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.	Lysine	36-42	hepatocyte growth factor	Homo sapiens	130-136
30090230-0	2015	Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.	Lysine	36-42	hepatocyte growth factor	Homo sapiens	174-180
30090230-5	2015	Several small molecules were found to bind in the lysine-binding pocket of the kringle 1 domain of HGF/SF and its truncated splice variant NK1.	Lysine	50-56	hepatocyte growth factor	Homo sapiens	99-105
30090230-7	2015	Thus we demonstrate that targeting the lysine-binding pocket of NK1 is an effective strategy to generate MET receptor antagonists and we offer proof of concept that the HGF/SF-MET interface may be successfully targeted with small molecules.	Lysine	39-45	hepatocyte growth factor	Homo sapiens	169-175
26320211-1	2015	The protein substrates of sirtuin 5-regulated lysine malonylation (Kmal) remain unknown, hindering its functional analysis.	Lysine	46-52	sirtuin 5	Homo sapiens	26-35
22561604-3	2012	Various cells can bind plasminogen and plasmin via plasminogen-binding sites exposing a C-terminal lysine.	Lysine	99-105	plasminogen	Homo sapiens	23-30
22561604-5	2012	Apart from its ability to facilitate cell migration in tissues, plasmin is capable of triggering signaling, which depends on cellular binding via its lysine-binding sites and its proteolytic activity.	Lysine	150-156	plasminogen	Homo sapiens	64-71
22864287-0	2012	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.	Lysine	43-49	PHD finger protein 20	Homo sapiens	0-5
22778253-7	2012	Here, we show that HDAC6 can be acetylated by p300 on five clusters of lysine residues.	Lysine	71-77	E1A binding protein p300	Homo sapiens	46-50
27965357-0	2017	Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells.	Lysine	33-36	SMAD family member 2	Homo sapiens	8-13
22732184-6	2012	In this regard, we and others have shown that MnSOD is regulated, at least in part, by the deacetylation of specific conserved lysines in a reaction catalyzed by the mitochondrial sirtuin, Sirt3.	Lysine	127-134	superoxide dismutase 2	Homo sapiens	46-51
22732184-7	2012	We speculate that the regulation of MnSOD activity by lysine acetylation via an electrostatic repulsion mechanism is a conserved and critical aspect of MnSOD regulation necessary to maintain mitochondrial homeostasis.	Lysine	54-60	superoxide dismutase 2	Homo sapiens	36-41
22732184-7	2012	We speculate that the regulation of MnSOD activity by lysine acetylation via an electrostatic repulsion mechanism is a conserved and critical aspect of MnSOD regulation necessary to maintain mitochondrial homeostasis.	Lysine	54-60	superoxide dismutase 2	Homo sapiens	152-157
28011638-5	2017	A lysine residue (Lys1112) at the C-terminal tail of mGluR1 (a member of the group I mGluR family) plays crucial role in this process.	Lysine	2-8	glutamate metabotropic receptor 1	Homo sapiens	53-59
25957834-1	2015	A novel multifunctional peptide fluorescent chemosensor (DP-3) with a lysine backbone and double sides conjugated with histidine and dansyl groups has been designed and synthesized by solid phase synthesis.	Lysine	70-76	APC regulator of WNT signaling pathway	Homo sapiens	57-61
27989401-0	2017	CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation.	Lysine	78-84	E1A binding protein p300	Homo sapiens	4-8
26269585-9	2015	Release of cavin1 from caveolae thus leads to exposure of key lysine residues in the PI-binding region, acting as a trigger for cavin1 ubiquitylation and down-regulation.	Lysine	62-68	caveolae associated protein 1	Homo sapiens	11-17
26269585-9	2015	Release of cavin1 from caveolae thus leads to exposure of key lysine residues in the PI-binding region, acting as a trigger for cavin1 ubiquitylation and down-regulation.	Lysine	62-68	caveolae associated protein 1	Homo sapiens	128-134
24832227-8	2012	This improved characterization of Tat.PCAF bromodomain binding may help in defining the structural determinants of other protein interactions involving lysine acetylation.	Lysine	152-158	lysine acetyltransferase 2B	Homo sapiens	38-42
27845897-1	2017	The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3.	Lysine	183-189	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	91-96
22707723-8	2012	Immunoprecipitation assays show that Nrdp1 interacts with and ubiquitinates transcriptional factor C/EBPbeta via Lys-63-linked ubiquitination.	Lysine	113-116	ring finger protein 41	Mus musculus	37-42
26330556-3	2015	MAGE-A11 degradation by the proteasome was mediated by an interaction with p14-ARF and was independent of lysine ubiquitination.	Lysine	106-112	MAGE family member A11	Homo sapiens	0-8
27585400-4	2017	When acetylated at lysine residues in the nuclear localization signal domains, HMGB1 is sequestered in the cytoplasm and is fated for secretion.	Lysine	19-25	high mobility group box 1	Mus musculus	79-84
26431207-5	2015	CUL4A-DDB1-CDT2 E3 ligase targets lysine 585 within the C-terminal region of CRY1 protein, shown by the CRY1 585KA mutant"s resistance to ubiquitination and degradation mediated by the CUL4A-DDB1 complex.	Lysine	34-40	denticleless E3 ubiquitin protein ligase homolog	Homo sapiens	11-15
22587366-6	2012	We found that Asp(358) (helix 7) and Lys(492) (helix 11) are critical for the transport function, and might be part of the putative substrate-binding pocket of Pho84.	Lysine	37-40	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	160-165
27604867-7	2017	Moreover, lysine 730 in human ZO-2 was identified as a potential modification site.	Lysine	10-16	tight junction protein 2	Homo sapiens	30-34
22710435-5	2012	Mass spectrometry results showed a complex pattern of MnSOD-methylation at both lysine (68, 89, 122, and 202) and arginine (197 and 216) residues.	Lysine	80-86	superoxide dismutase 2	Homo sapiens	54-59
22710435-7	2012	Computational-based simulations indicate that lysine and arginine methylation of MnSOD during quiescence would allow greater accessibility to the enzyme active site as well as increase the positive electrostatic potential around and within the active site.	Lysine	46-52	superoxide dismutase 2	Homo sapiens	81-86
26256448-5	2015	A chromatin immunoprecipitation assay revealed that miR-139 was epigenetically silenced by histone H3 lysine 27 trimethylation (H3K27me3) of its host gene PDE2A and this process was independent of promoter DNA methylation.	Lysine	102-108	phosphodiesterase 2A	Homo sapiens	155-160
28056232-6	2016	A mutation c. A1319G was identified in the MYLK2 gene in 1 family member, which resulted in a lysine (K) to arginine (R) exchange at amino acid residue 440.	Lysine	94-100	myosin light chain kinase 2	Homo sapiens	43-48
26272920-3	2015	We have used a cellular model of conditionally inactive polycomb E3 ligases (RING1A and RING1B), which monoubiquitylate lysine 119 of histone H2A (H2AK119Ub), to examine DNA replication in unperturbed cells.	Lysine	120-126	ring finger protein 1	Homo sapiens	77-83
26272920-3	2015	We have used a cellular model of conditionally inactive polycomb E3 ligases (RING1A and RING1B), which monoubiquitylate lysine 119 of histone H2A (H2AK119Ub), to examine DNA replication in unperturbed cells.	Lysine	120-126	ring finger protein 2	Homo sapiens	88-94
22020899-6	2012	Importantly, we found that KDM3A activates transcription of the HOXA1 gene through demethylating histone H3 at lysine 9 di-methylation by binding to its promoter region.	Lysine	111-117	homeobox A1	Homo sapiens	64-69
27798240-6	2016	A combination of genetics, fluorescence microscopy, and biochemistry reveals three critical features that comprise an ART sorting signal in the Mup1 N-terminal cytosolic tail: 1) an extended acidic patch, 2) in close proximity to the first Mup1 transmembrane domain, and 3) close to the ubiquitinated lysines.	Lysine	301-308	Mup1p	Saccharomyces cerevisiae S288C	144-148
22467095-8	2012	5hmC increment following TET2 re-activation was associated with the reduction of histone H3 tri-methylation at lysine 9 (H3K9me3), which may contribute with DNA de-methylation reported elsewhere to recast a permissive epigenetic "landscape" for FoxO3a transcriptional activity.	Lysine	111-117	tet methylcytosine dioxygenase 2	Homo sapiens	25-29
22589545-6	2012	These findings support the hypothesis that RNF8 is responsible for the initiation of Lys-63-linked ubiquitylation in the DNA damage response, which is subsequently amplified by RNF168.	Lysine	85-88	ring finger protein 168	Homo sapiens	177-183
26344566-5	2015	Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy.	Lysine	150-153	peroxisomal biogenesis factor 5	Homo sapiens	91-95
26344566-5	2015	Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy.	Lysine	150-153	peroxisomal biogenesis factor 5	Homo sapiens	123-127
26344566-5	2015	Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy.	Lysine	150-153	peroxisomal biogenesis factor 5	Homo sapiens	123-127
27825936-7	2016	Using a "bottom-up" methodology, involving the analysis of tryptic peptides by liquid chromatography - high resolution mass spectrometry, we obtained evidence for a cross-link between GSH-BDA and lysine 107 of histone H2B isolated from the livers of male F344 rats treated with tumorigenic doses of furan.	Lysine	196-202	H2B clustered histone 12	Rattus norvegicus	210-221
26172293-4	2015	Thereby, the SETD2 binding capacity to substrate histone H3 is weakened, triggering a reduction of trimethylation on histone H3 thirty-sixth lysine, and thereby the H3K36me3-hMSH2-hMSH6-SKP2 complex is also decreased.	Lysine	141-147	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	13-18
26172293-4	2015	Thereby, the SETD2 binding capacity to substrate histone H3 is weakened, triggering a reduction of trimethylation on histone H3 thirty-sixth lysine, and thereby the H3K36me3-hMSH2-hMSH6-SKP2 complex is also decreased.	Lysine	141-147	mutS homolog 2	Homo sapiens	174-179
26172293-4	2015	Thereby, the SETD2 binding capacity to substrate histone H3 is weakened, triggering a reduction of trimethylation on histone H3 thirty-sixth lysine, and thereby the H3K36me3-hMSH2-hMSH6-SKP2 complex is also decreased.	Lysine	141-147	S-phase kinase associated protein 2	Homo sapiens	186-190
22646918-2	2012	PLP forms a Schiff base with the epsilon-amino group of a lysine residue of PLP-dependent enzymes.	Lysine	58-64	pyridoxal phosphatase	Homo sapiens	0-3
22646918-2	2012	PLP forms a Schiff base with the epsilon-amino group of a lysine residue of PLP-dependent enzymes.	Lysine	58-64	pyridoxal phosphatase	Homo sapiens	76-79
27187575-6	2016	YKL-40 is a plasma protein named after its three N-terminal amino acids, Y (tyrosine), K (lysine) and L (leucine), and its molecular weight of 40 kDa.	Lysine	90-96	chitinase 3 like 1	Homo sapiens	0-6
22556262-3	2012	Here, we show that SETD8 regulates the function of proliferating cell nuclear antigen (PCNA) protein through lysine methylation.	Lysine	109-115	lysine methyltransferase 5A	Homo sapiens	19-24
22556262-4	2012	We found that SETD8 methylated PCNA on lysine 248, and either depletion of SETD8 or substitution of lysine 248 destabilized PCNA expression.	Lysine	39-45	lysine methyltransferase 5A	Homo sapiens	14-19
22402492-5	2012	DNA damage stimulates sumoylation of BMI1 by CBX4 at lysine 88, which is required for the accumulation of BMI1 at DNA damage sites.	Lysine	53-59	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	37-41
26365310-4	2015	In our functional assays, LRRK2 binds to focal adhesion kinase (FAK) and phosphorylates its Thr-X-Arg/Lys (TXR/K) motif(s), eventually attenuating FAK activity marked by decreased pY397 phosphorylation (pY397).	Lysine	102-105	protein tyrosine kinase 2	Homo sapiens	41-62
26365310-4	2015	In our functional assays, LRRK2 binds to focal adhesion kinase (FAK) and phosphorylates its Thr-X-Arg/Lys (TXR/K) motif(s), eventually attenuating FAK activity marked by decreased pY397 phosphorylation (pY397).	Lysine	102-105	protein tyrosine kinase 2	Homo sapiens	64-67
27748806-5	2016	In this study, we found that lncUSMycN upregulated NCYM expression, and knocking-down lncUSMycN reduced histone H3 lysine 4 trimethylation, a marker for active gene transcription, at the NCYM gene promoter.	Lysine	115-121	MYCN opposite strand	Homo sapiens	187-191
26092122-1	2015	WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3.	Lysine	91-97	PR/SET domain 9	Homo sapiens	11-36
26092122-1	2015	WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3.	Lysine	91-97	PR/SET domain 9	Homo sapiens	38-41
22813742-4	2012	In particular, we identified human FOXP3 K250 and K252 as key residues for the conformational change and stability of the FOXP3 dimer, which can be regulated by protein posttranslational modifications such as reversible lysine acetylation.	Lysine	220-226	forkhead box P3	Homo sapiens	35-40
22813742-4	2012	In particular, we identified human FOXP3 K250 and K252 as key residues for the conformational change and stability of the FOXP3 dimer, which can be regulated by protein posttranslational modifications such as reversible lysine acetylation.	Lysine	220-226	forkhead box P3	Homo sapiens	122-127
28105224-5	2016	In addition, the histone modification status of the PDCD4 gene was analyzed, and chromatin immunoprecipitation assay identified a high density of histone 3 lysine 27 trimethylation on the promoter of PDCD4, which was associated with the long non-coding RNA, homeobox transcript antisense RNA (HOTAIR).	Lysine	156-162	programmed cell death 4	Homo sapiens	52-57
26435136-6	2015	RESULTS: Overexpression of SUMO led to sumoylation of Hes6 at both lysine 27 and 30.	Lysine	67-73	hairy and enhancer of split 6	Mus musculus	54-58
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Lysine	52-55	serine protease 3	Homo sapiens	152-163
22544757-5	2012	This YAP acetylation occurs on specific and highly conserved C-terminal lysine residues and is mediated by the nuclear acetyltransferases CBP (CREB binding protein) and p300.	Lysine	72-78	Yes1 associated transcriptional regulator	Homo sapiens	5-8
28105224-5	2016	In addition, the histone modification status of the PDCD4 gene was analyzed, and chromatin immunoprecipitation assay identified a high density of histone 3 lysine 27 trimethylation on the promoter of PDCD4, which was associated with the long non-coding RNA, homeobox transcript antisense RNA (HOTAIR).	Lysine	156-162	programmed cell death 4	Homo sapiens	200-205
22544757-5	2012	This YAP acetylation occurs on specific and highly conserved C-terminal lysine residues and is mediated by the nuclear acetyltransferases CBP (CREB binding protein) and p300.	Lysine	72-78	E1A binding protein p300	Homo sapiens	169-173
27626683-0	2016	SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.	Lysine	15-21	SET and MYND domain containing 3	Homo sapiens	0-5
27626683-3	2016	Here we demonstrate that the protein lysine methyltrasnferase SMYD3 methylates lysine 14 in the PH domain of AKT1 both in vitro and in vivo.	Lysine	37-43	SET and MYND domain containing 3	Homo sapiens	62-67
26118539-3	2015	By employing a biocompatible condensation reaction, we rationally designed a taxol derivative Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(taxol)-2-cyanobenzothiazole (CBT-Taxol) which could be subjected to furin-controlled condensation and self-assembly of taxol nanoparticles (Taxol-NPs).	Lysine	123-126	furin, paired basic amino acid cleaving enzyme	Homo sapiens	195-200
22609403-4	2012	We found that 21.5-kDa MBP contains two non-traditional PY-nuclear-localization signals, and that arginine and lysine residues within these motifs were involved in subcellular trafficking of this protein to the nucleus, where it may have functional roles during myelinogenesis.	Lysine	111-117	myelin basic protein	Homo sapiens	23-26
27626683-4	2016	Lysine 14-substituted AKT1 shows significantly lower levels of phosphorylation at threonine 308 than wild-type AKT1, and knockdown of SMYD3 as well as treatment with a SMYD3 inhibitor significantly attenuates this phosphorylation in cancer cells.	Lysine	0-6	SET and MYND domain containing 3	Homo sapiens	134-139
27626683-4	2016	Lysine 14-substituted AKT1 shows significantly lower levels of phosphorylation at threonine 308 than wild-type AKT1, and knockdown of SMYD3 as well as treatment with a SMYD3 inhibitor significantly attenuates this phosphorylation in cancer cells.	Lysine	0-6	SET and MYND domain containing 3	Homo sapiens	168-173
27626683-6	2016	These results imply that SMYD3-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation and that SMYD3-mediated AKT1 methylation appears to be a good target for development of anti-cancer therapy.	Lysine	63-69	SET and MYND domain containing 3	Homo sapiens	25-30
22615379-1	2012	Histone acetyltransferase 1 is the founding member of the histone acetyltransferase superfamily and catalyzes lysine acetylation of newly synthesized histone H4.	Lysine	110-116	histone acetyltransferase 1	Homo sapiens	0-27
27845446-1	2016	SETD3 is a member of the protein lysine methyltransferase (PKMT) family, which catalyzes the addition of methyl group to lysine residues.	Lysine	33-39	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	0-5
25987439-5	2015	Besides acting as a NAT in the NatA complex, recently other functions have been linked to Naa10, including post-translational NTA, lysine acetylation, and NAT/KAT-independent functions.	Lysine	131-137	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	90-95
22787429-4	2012	According to an in vitro methyltransferase assay, we found that SMYD2 methylates RB1 protein, and liquid chromatography-tandem mass spectrometry analysis revealed lysine 810 of RB1 to be methylated by SMYD2.	Lysine	163-169	RB transcriptional corepressor 1	Homo sapiens	177-180
27831563-8	2016	Using this original approach, we demonstrate that the tPA binds the NTD of the GluN1 subunit at a lysine in position 178.	Lysine	98-104	plasminogen activator, tissue	Mus musculus	54-57
22787429-7	2012	SMYD2 is an important oncoprotein in various types of cancer, and SMYD2-dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells.	Lysine	101-107	RB transcriptional corepressor 1	Homo sapiens	82-85
26100207-7	2015	The NMR resonances of Lys (177, 178, 179), Gly182, and Ser183 in the C1 region and Lys193 and Lys194 in the V region of syndecan-4 are perturbed upon syndesmos binding.	Lysine	22-25	syndecan 4	Homo sapiens	120-130
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	interleukin 4	Bos taurus	283-296
23189823-3	2012	TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination.	Lysine	49-55	stimulator of interferon response cGAMP interactor 1	Homo sapiens	23-28
27439711-6	2016	We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression.	Lysine	104-110	SET domain containing (lysine methyltransferase) 7	Mus musculus	11-15
22541069-6	2012	DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.	Lysine	87-93	ASH1 like histone lysine methyltransferase	Homo sapiens	43-48
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	interleukin 4	Bos taurus	298-302
26059252-3	2015	Peptides with short linkers (&lt;25 atoms) conjugated at Lys(34) and Lys(37) displayed strong GLP-1 receptor (GLP-1-R) binding affinity.	Lysine	57-60	glucagon like peptide 1 receptor	Homo sapiens	94-108
26059252-3	2015	Peptides with short linkers (&lt;25 atoms) conjugated at Lys(34) and Lys(37) displayed strong GLP-1 receptor (GLP-1-R) binding affinity.	Lysine	57-60	glucagon like peptide 1 receptor	Homo sapiens	110-117
27806304-5	2016	We demonstrate that overnutrition facilitates the recruitment of MLL4 to steatotic target genes of PPARgamma2 and their transactivation via H3 lysine 4 methylation because PPARgamma2 phosphorylated by overnutrition-activated ABL1 kinase shows enhanced interaction with MLL4.	Lysine	143-149	peroxisome proliferator activated receptor gamma	Mus musculus	99-109
26059252-3	2015	Peptides with short linkers (&lt;25 atoms) conjugated at Lys(34) and Lys(37) displayed strong GLP-1 receptor (GLP-1-R) binding affinity.	Lysine	69-72	glucagon like peptide 1 receptor	Homo sapiens	94-108
26059252-3	2015	Peptides with short linkers (&lt;25 atoms) conjugated at Lys(34) and Lys(37) displayed strong GLP-1 receptor (GLP-1-R) binding affinity.	Lysine	69-72	glucagon like peptide 1 receptor	Homo sapiens	110-117
22403398-2	2012	In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.	Lysine	122-125	ubiquitin conjugating enzyme E2 I	Homo sapiens	164-168
22403398-2	2012	In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.	Lysine	191-194	ubiquitin conjugating enzyme E2 I	Homo sapiens	164-168
27806304-5	2016	We demonstrate that overnutrition facilitates the recruitment of MLL4 to steatotic target genes of PPARgamma2 and their transactivation via H3 lysine 4 methylation because PPARgamma2 phosphorylated by overnutrition-activated ABL1 kinase shows enhanced interaction with MLL4.	Lysine	143-149	peroxisome proliferator activated receptor gamma	Mus musculus	172-182
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c oxidase subunit 8A	Homo sapiens	41-44
25908444-7	2015	The lysine 68 (K68) site is the most important acetylation site contributing to SOD2 activation and plays a role in cell survival after paraquat treatment.	Lysine	4-10	superoxide dismutase 2	Homo sapiens	80-84
27638352-4	2016	Here, we direct our focus to two primary players in enhancer regulation and their role in cancer pathogenesis: MLL3 and MLL4, members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase.	Lysine	170-176	lysine methyltransferase 2C	Homo sapiens	111-115
26226047-3	2015	Here, we report that cellular ubiquitin is a substrate of ISG15 and Lys 29 on ubiquitin is the major ISG15 acceptor site.	Lysine	68-71	ISG15 ubiquitin like modifier	Homo sapiens	101-106
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
23586831-1	2012	Reduction of O2 by cytochrome c oxidase (COX) is critical to the cellular production of adenosine-5"-triphosphate; COX obtains the four electrons required for this process from ferrocytochrome c. The COX-cytochrome c enzyme-substrate complex is stabilized by electrostatic interactions via carboxylates on COX and lysines on cytochrome c.	Lysine	314-321	cytochrome c oxidase subunit 8A	Homo sapiens	115-118
22375025-5	2012	Human PMSC is illuminated with epigenetic modifications such as trimethylated lysine 9 of histone H3 and heterochromatin proteins CBX1 and CBX3, which implicate a conserved mechanism underlying the maintenance of sex chromosome inactivation in mammals.	Lysine	78-84	chromobox 3	Homo sapiens	139-143
27638352-4	2016	Here, we direct our focus to two primary players in enhancer regulation and their role in cancer pathogenesis: MLL3 and MLL4, members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase.	Lysine	170-176	lysine methyltransferase 2B	Homo sapiens	120-124
27638352-4	2016	Here, we direct our focus to two primary players in enhancer regulation and their role in cancer pathogenesis: MLL3 and MLL4, members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase.	Lysine	259-265	lysine methyltransferase 2C	Homo sapiens	111-115
27638352-4	2016	Here, we direct our focus to two primary players in enhancer regulation and their role in cancer pathogenesis: MLL3 and MLL4, members of the COMPASS family of histone H3 lysine 4 (H3K4) methyltransferases, and their complex-specific subunit UTX, a histone H3 lysine 27 (H3K27) demethylase.	Lysine	259-265	lysine methyltransferase 2B	Homo sapiens	120-124
27317772-3	2016	Both NSD1 and SETD2 genes encode epigenetic "writer" proteins that catalyse methylation of histone 3 lysine 36 (H3K36me).	Lysine	101-107	nuclear receptor binding SET domain protein 1	Homo sapiens	5-9
22114864-3	2012	Here, we demonstrate that a single dose of LY 341495, an mGluR2/3 antagonist, produces ketamine-like biochemical and behavioural actions.	Lysine	43-45	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	57-63
25990740-5	2015	Unspliced LEF1 NAT interacts with LEF1 promoter and facilitates PRC2 binding to the LEF1 promoter and trimethylation of lysine 27 in histone 3.	Lysine	120-126	lymphoid enhancer binding factor 1	Homo sapiens	10-14
25903134-0	2015	Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.	Lysine	147-153	coagulation factor VIII	Homo sapiens	0-11
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	106-112	coagulation factor VIII	Homo sapiens	209-220
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	106-112	coagulation factor VIII	Homo sapiens	222-227
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	290-296	coagulation factor VIII	Homo sapiens	209-220
22445450-9	2012	In the striatum, Lys administration provoked a marked increase of lipid peroxidation, DCFH oxidation, SOD and GR activities, as well as significant reductions of GSH levels and GPx activity, with no alteration of sulfhydryl content, CAT and G6PD activities.	Lysine	17-20	glutathione reductase	Mus musculus	110-112
27317772-3	2016	Both NSD1 and SETD2 genes encode epigenetic "writer" proteins that catalyse methylation of histone 3 lysine 36 (H3K36me).	Lysine	101-107	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	14-19
25903134-4	2015	Using hydrogen-deuterium exchange mass spectrometry (HDX-MS) and SPR interaction analysis on a library of lysine replacement variants as two independent approaches, we demonstrate that the interaction between factor VIII (FVIII) and LRP1 occurs over an extended surface containing multiple lysine residues.	Lysine	290-296	coagulation factor VIII	Homo sapiens	222-227
27659526-5	2016	In this study, we show that ARD1 acetylates AR at lysine 618 (K618) in vitro and in vivo.	Lysine	50-56	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	28-32
22374868-5	2012	Site-directed mutagenesis of the LZ-GCN4 RNA binding interface showed that substrate binding is facilitated by lysine and arginine side chains, and that at least one nucleophilic residue is located in proximity to the RNA phosphate backbone.	Lysine	111-117	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	36-40
27760318-4	2016	We show that the plant homeodomain (PHD) finger of PHF20 recognizes dimethylated lysine 4 of histone H3 (H3K4me2) and represents an example of a native reader that selects for this modification.	Lysine	81-87	PHD finger protein 20	Homo sapiens	51-56
22418431-8	2012	Furthermore, we found that the functional region of SP-A lies within Tyr(161)-Lys(201).	Lysine	78-81	surfactant protein A1	Homo sapiens	52-56
26140605-4	2015	Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.	Lysine	0-6	E1A binding protein p300	Homo sapiens	57-61
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	134-140	hematopoietic SH2 domain containing	Homo sapiens	53-56
25754661-2	2015	For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (PRCs) to target genes in which the binding of PRC2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of PRC1, which in turn mediated H2A monoubiquitination.	Lysine	198-204	protein regulator of cytokinesis 1	Homo sapiens	246-250
22315414-2	2012	We report on the identification of a small molecule inhibitor that attains its selectivity by forming an unusually stable Schiff base with lysine 907 in the IRE1 endonuclease domain, explained by solvent inaccessibility of the imine bond in the enzyme-inhibitor complex.	Lysine	139-145	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	157-161
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	55-58	cullin 4B	Homo sapiens	151-156
26029848-5	2015	The interaction of PAM with Plg is believed to be mediated by lysine binding sites within kringle (KR) 2 of Plg.	Lysine	62-68	plasminogen	Homo sapiens	28-31
26029848-5	2015	The interaction of PAM with Plg is believed to be mediated by lysine binding sites within kringle (KR) 2 of Plg.	Lysine	62-68	plasminogen	Homo sapiens	108-111
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	166-172	hematopoietic SH2 domain containing	Homo sapiens	53-56
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	55-58	damage specific DNA binding protein 2	Homo sapiens	157-161
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	63-66	cullin 4B	Homo sapiens	151-156
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	166-172	hematopoietic SH2 domain containing	Homo sapiens	53-56
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	63-66	damage specific DNA binding protein 2	Homo sapiens	157-161
22334663-7	2012	Nucleosomes in which these lysines are replaced with arginines are resistant to such structural changes, and arginine mutants prevent the eviction of H2A and dissociation of polyubiquitinated DDB2 from UV-damaged nucleosomes.	Lysine	27-34	damage specific DNA binding protein 2	Homo sapiens	192-196
26029848-6	2015	PAM-GI-Plg interactions were fully inhibited with 100 mM lysine analogue epsilon-aminocaproic acid (epsilonACA), whereas PAM-GII-Plg interactions were shown to be weakened but not inhibited in the presence of 400 mM epsilonACA.	Lysine	57-63	plasminogen	Homo sapiens	7-10
27480105-5	2016	SMYD2 methylates lysine-8 (K8) within a -(8)KSKK(11)- motif embedded in the GFI1 SNAG domain.	Lysine	17-23	SET and MYND domain containing 2a	Danio rerio	0-5
25969923-4	2015	ALP is simply conjugated to a ZFP through lysine residues in a ZFP purification tag, a maltose binding protein (MBP).	Lysine	42-48	myelin basic protein	Homo sapiens	87-110
25969923-4	2015	ALP is simply conjugated to a ZFP through lysine residues in a ZFP purification tag, a maltose binding protein (MBP).	Lysine	42-48	myelin basic protein	Homo sapiens	112-115
25101918-10	2012	Increased IGF1r expression was associated with more histone 3 lysine 4 dimethylation (H3K4Me2) in the promoter region.	Lysine	62-68	insulin-like growth factor 1 receptor	Rattus norvegicus	10-15
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	Wnt family member 3A	Homo sapiens	86-89
22334673-6	2012	Furthermore, threonine 152-phosphorylated BLNK is ubiquitinated at lysine residues 37, 38, and 42, leading to attenuation of MAPK and IkappaB kinase activation in B cells during BCR signaling.	Lysine	67-73	B cell linker	Homo sapiens	42-46
25911107-0	2015	Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity.	Lysine	51-57	histone deacetylase 3	Homo sapiens	0-21
27528606-6	2016	However, Imp5, Imp7, Imp9, and Impalpha bind two separate elements in the H3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.	Lysine	131-137	importin 5	Homo sapiens	9-13
25911107-0	2015	Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity.	Lysine	51-57	histone deacetylase 3	Homo sapiens	23-28
22337870-2	2012	The interaction of Rtt106 with H3-H4 is modulated by acetylation of H3 lysine 56 catalyzed by the lysine acetyltransferase Rtt109.	Lysine	71-77	Rtt106p	Saccharomyces cerevisiae S288C	19-25
27528607-0	2016	Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.	Lysine	179-182	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	54-59
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Lysine	232-235	F2R like trypsin receptor 1	Homo sapiens	41-46
27685940-1	2016	Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo.	Lysine	111-117	von Hippel-Lindau tumor suppressor	Homo sapiens	157-161
22398447-3	2012	Here we show that ORC1--a component of ORC (origin of replication complex), which mediates pre-DNA replication licensing--contains a bromo adjacent homology (BAH) domain that specifically recognizes histone H4 dimethylated at lysine 20 (H4K20me2).	Lysine	226-232	origin recognition complex subunit 1	Homo sapiens	18-22
22398447-10	2012	Together, our results identify the BAH domain as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism.	Lysine	64-70	origin recognition complex subunit 1	Homo sapiens	280-284
25934149-0	2015	Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.	Lysine	0-6	X-ray repair cross complementing 4	Homo sapiens	33-38
25934149-0	2015	Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.	Lysine	0-6	X-ray repair cross complementing 4	Homo sapiens	83-88
25538301-1	2015	ATRX (the alpha thalassemia/mental retardation syndrome X-linked protein) is a member of the switch2/sucrose nonfermentable2 (SWI2/SNF2) family of chromatin-remodeling proteins and primarily functions at heterochromatic loci via its recognition of "repressive" histone modifications [e.g., histone H3 lysine 9 tri-methylation (H3K9me3)].	Lysine	301-307	ATRX chromatin remodeler	Homo sapiens	0-4
27685940-5	2016	The Lys76 residue of UCP was the most critical site for auto-ubiquitination, whereas the polyubiquitin chain formation on pVHL occurred on all three of its lysines (Lys159, Lys171 and Lys196).	Lysine	156-163	von Hippel-Lindau tumor suppressor	Homo sapiens	122-126
25538301-1	2015	ATRX (the alpha thalassemia/mental retardation syndrome X-linked protein) is a member of the switch2/sucrose nonfermentable2 (SWI2/SNF2) family of chromatin-remodeling proteins and primarily functions at heterochromatic loci via its recognition of "repressive" histone modifications [e.g., histone H3 lysine 9 tri-methylation (H3K9me3)].	Lysine	301-307	ATRX chromatin remodeler	Homo sapiens	10-72
25538301-1	2015	ATRX (the alpha thalassemia/mental retardation syndrome X-linked protein) is a member of the switch2/sucrose nonfermentable2 (SWI2/SNF2) family of chromatin-remodeling proteins and primarily functions at heterochromatic loci via its recognition of "repressive" histone modifications [e.g., histone H3 lysine 9 tri-methylation (H3K9me3)].	Lysine	301-307	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	126-130
22194422-10	2012	The increase of p21(Cip1) was associated with increased acetylation of both histone H3 and H4 and decreased trimethylation of histone H3 lysine-27 at the p21(Cip1) promoter.	Lysine	137-143	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	20-24
27688818-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	0-5
22194422-10	2012	The increase of p21(Cip1) was associated with increased acetylation of both histone H3 and H4 and decreased trimethylation of histone H3 lysine-27 at the p21(Cip1) promoter.	Lysine	137-143	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	158-162
22194422-11	2012	In the p21(Cip1) coding region, dimethylation of histone H3 lysine-4 was significantly higher (P &lt;0.05) in livers of OP rats compared with OR rats.	Lysine	60-66	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	11-15
25538301-3	2015	Here, we describe ATRX"s ability to recognize an activity-dependent combinatorial histone modification, histone H3 lysine 9 tri-methylation/serine 10 phosphorylation (H3K9me3S10ph), in postmitotic neurons.	Lysine	115-121	ATRX chromatin remodeler	Homo sapiens	18-22
27688818-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	6-10
26137204-3	2015	The bromodomain and extra-terminal (BET) proteins are epigenetic readers which utilize tandem bromodomains (BRD) modules to recognize and dock themselves on the acetylated lysine tails.	Lysine	172-178	delta/notch like EGF repeat containing	Homo sapiens	36-39
27688818-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	11-18
27688818-1	2016	SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo.	Lysine	43-49	lysine methyltransferase 5A	Homo sapiens	19-24
21886178-0	2012	Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.	Lysine	48-54	BIR repeat containing ubiquitin-conjugating enzyme	Drosophila melanogaster	11-16
21886178-8	2012	Unexpectedly, we found that dBruce also affects the levels of a mutant form of Reaper without any internal lysine residues, which normally serve as conventional ubiquitin acceptor sites.	Lysine	107-113	BIR repeat containing ubiquitin-conjugating enzyme	Drosophila melanogaster	28-34
27625115-3	2016	We recently showed that both monomers and dimers are potent CXCR2 agonists, the dimer is the high-affinity GAG ligand, lysine and arginine residues located in two non-overlapping domains mediate GAG interactions, and there is extensive overlap between GAG and receptor-binding domains.	Lysine	119-125	C-X-C motif chemokine receptor 2	Homo sapiens	60-65
21886178-9	2012	Furthermore, we were able to biochemically detect ubiquitin conjugation on lysine-deficient Reaper proteins, and knockdown of dBruce significantly reduced the extent of this ubiquitination.	Lysine	75-81	BIR repeat containing ubiquitin-conjugating enzyme	Drosophila melanogaster	126-132
25947153-9	2015	Moreover, we show that the LANA DBD can coat DNA of arbitrary sequence by virtue of a characteristic lysine patch, which is absent in EBNA-1 of the Epstein-Barr virus.	Lysine	101-107	LANA	Human gammaherpesvirus 8	27-31
25786853-7	2015	We found that reducing the levels of histone H4 lysine 16 acetylation or H3 lysine 79 methylation partially suppresses these sensitivities and reduces spontaneous and genotoxin-induced activation of the DNA damage-response kinase Rad53 in hst3  hst4  cells.	Lysine	48-54	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	230-235
22279139-7	2012	Subsequent chromatin immunoprecipitation analysis further demonstrated that the binding of p300/CBP-associated factor, a coactivator of SREBP-1c, and histone H3 lysine 14 acetylation at the FAS, SCD1, and ACC1 promoters were significantly reduced in the livers of APOE2 mice and HepG2 cells treated with MOEO compared with their controls.	Lysine	161-167	K(lysine) acetyltransferase 2B	Mus musculus	91-117
27604544-1	2016	Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from partially degraded fibrin.	Lysine	147-154	carboxypeptidase B2	Homo sapiens	7-50
25786853-7	2015	We found that reducing the levels of histone H4 lysine 16 acetylation or H3 lysine 79 methylation partially suppresses these sensitivities and reduces spontaneous and genotoxin-induced activation of the DNA damage-response kinase Rad53 in hst3  hst4  cells.	Lysine	76-82	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	230-235
27606599-3	2016	Here we show an alternative method to generate polyclonal pan-acetyl-lysine antibodies using a synthesized random library of acetylated peptides as the antigen.	Lysine	69-75	adenosine deaminase 2	Homo sapiens	58-61
25705961-7	2015	Previous studies with poly-L-lysine (PLL) and heparin-based PEC carriers amplified the therapeutic efficacy of low-dose BMP-2.	Lysine	22-35	bone morphogenetic protein 2	Rattus norvegicus	120-125
22499511-8	2012	Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.	Lysine	9-15	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	156-161
22499511-8	2012	Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.	Lysine	9-15	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	243-248
27131378-0	2016	Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.	Lysine	26-32	PR/SET domain containing protein 7	Drosophila melanogaster	39-46
22345516-3	2012	Here we show that the transcriptional activator Gcn4 is sumoylated on two specific lysine residues and in a manner that depends on its ability to bind DNA, indicating that sumoylation occurs after Gcn4 binding to target promoters.	Lysine	83-89	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	48-52
25823821-2	2015	Here we report that Shp2 is modified by SUMO1 at lysine residue 590 (K590) in its C-terminus, which is reduced by SUMO1-specific protease SENP1.	Lysine	49-55	small ubiquitin like modifier 1	Homo sapiens	40-45
25823821-2	2015	Here we report that Shp2 is modified by SUMO1 at lysine residue 590 (K590) in its C-terminus, which is reduced by SUMO1-specific protease SENP1.	Lysine	49-55	small ubiquitin like modifier 1	Homo sapiens	114-119
25713082-4	2015	Using mass spectrometry and mutational analysis of purified proteins, we found that Set7/9 methylates the N-terminal residues Lys-123 and Lys-131 of Pdx1.	Lysine	138-141	SET domain containing (lysine methyltransferase) 7	Mus musculus	84-90
25713082-4	2015	Using mass spectrometry and mutational analysis of purified proteins, we found that Set7/9 methylates the N-terminal residues Lys-123 and Lys-131 of Pdx1.	Lysine	138-141	pancreatic and duodenal homeobox 1	Mus musculus	149-153
25713082-7	2015	Cell-based luciferase reporter assays using wild-type and mutant transgenes revealed a requirement of Pdx1 residue Lys-131, but not Lys-123, for transcriptional augmentation by Set7/9.	Lysine	115-118	pancreatic and duodenal homeobox 1	Mus musculus	102-106
25713082-7	2015	Cell-based luciferase reporter assays using wild-type and mutant transgenes revealed a requirement of Pdx1 residue Lys-131, but not Lys-123, for transcriptional augmentation by Set7/9.	Lysine	115-118	SET domain containing (lysine methyltransferase) 7	Mus musculus	177-183
22399799-6	2012	Furthermore, we show that Gfi-1B includes a KSKK motif in its SNAG domain, which recruits the repressor complex only when dimethylated on lysine 8.	Lysine	138-144	growth factor independent 1B transcriptional repressor	Homo sapiens	26-32
22399799-7	2012	Mutation of lysine 8 prevents Gfi-1B p32-induced erythroid development.	Lysine	12-18	growth factor independent 1B transcriptional repressor	Homo sapiens	30-36
22399799-7	2012	Mutation of lysine 8 prevents Gfi-1B p32-induced erythroid development.	Lysine	12-18	inhibitor of growth family member 2	Homo sapiens	37-40
27179641-5	2016	Mutagenesis showed that asparagine-N200 and aspartate-D201 inside transmembrane5 (TM5), and lysine-K355 inside TM10 are critical for AtCHX17 activity.	Lysine	92-98	cation/H+ exchanger 17	Arabidopsis thaliana	133-140
21725364-2	2012	Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that enzymes that regulate histone H3 lysine 4 trimethylation (H3K4Me3), such as JARID1C/KDM5C/SMCX and MLL2, were mutated in ccRCC tumors, suggesting that H3K4Me3 might have an important role in regulating gene expression and tumorigenesis.	Lysine	112-118	lysine demethylase 5C	Homo sapiens	155-162
21725364-2	2012	Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that enzymes that regulate histone H3 lysine 4 trimethylation (H3K4Me3), such as JARID1C/KDM5C/SMCX and MLL2, were mutated in ccRCC tumors, suggesting that H3K4Me3 might have an important role in regulating gene expression and tumorigenesis.	Lysine	112-118	lysine demethylase 5C	Homo sapiens	163-168
21725364-2	2012	Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that enzymes that regulate histone H3 lysine 4 trimethylation (H3K4Me3), such as JARID1C/KDM5C/SMCX and MLL2, were mutated in ccRCC tumors, suggesting that H3K4Me3 might have an important role in regulating gene expression and tumorigenesis.	Lysine	112-118	lysine demethylase 5C	Homo sapiens	169-173
21725364-2	2012	Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that enzymes that regulate histone H3 lysine 4 trimethylation (H3K4Me3), such as JARID1C/KDM5C/SMCX and MLL2, were mutated in ccRCC tumors, suggesting that H3K4Me3 might have an important role in regulating gene expression and tumorigenesis.	Lysine	112-118	lysine methyltransferase 2B	Homo sapiens	178-182
25713144-0	2015	Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.	Lysine	152-155	serpin family A member 10	Homo sapiens	58-88
25713144-0	2015	Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.	Lysine	152-155	serpin family A member 10	Homo sapiens	90-93
25713144-0	2015	Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.	Lysine	152-155	serpin family A member 10	Homo sapiens	148-151
25713144-10	2015	Together, these results reveal the energetic basis of the ZPI-PZ interaction and suggest an important role for ZPI Lys-239 in PZ catalytic action.	Lysine	115-118	serpin family A member 10	Homo sapiens	58-61
25713144-10	2015	Together, these results reveal the energetic basis of the ZPI-PZ interaction and suggest an important role for ZPI Lys-239 in PZ catalytic action.	Lysine	115-118	serpin family A member 10	Homo sapiens	111-114
27198500-6	2016	Furthermore, we used chromatin immunoprecipitation (ChIP) technology and demonstrated that the sequences directly flanking IKZF1 Delta3-6 deletion breakpoints have significantly higher levels of histone H3 lysine 4 trimethylation (H3K4me3) modifications.	Lysine	206-212	IKAROS family zinc finger 1	Homo sapiens	123-128
25607372-10	2015	This targeting to transcribed sequences requires SETD2-mediated methylation of lysine 36 on histone H3 and a functional PWWP domain of DNMT3B.	Lysine	79-85	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	49-54
22307274-3	2012	In Saccharomyces cerevisiae, the histone chaperone Rtt106 contributes to the deposition of newly synthesized H3K56ac-carrying H3-H4 complex on replicating DNA, but it is unclear how Rtt106 binds H3-H4 and specifically recognizes H3K56ac as there is no apparent acetylated lysine reader domain in Rtt106.	Lysine	272-278	Rtt106p	Saccharomyces cerevisiae S288C	51-57
27369108-1	2016	SETD8 is the methyltransferase responsible for monomethylation of lysine at position 20 of the N-terminus of histone H4 (H4K20).	Lysine	66-72	lysine methyltransferase 5A	Homo sapiens	0-5
22200923-7	2012	Most CPP with C-terminal lysines probably arose from the activity of plasmin; an enzyme most active in casein hydrolysis.	Lysine	25-32	plasminogen	Homo sapiens	69-76
25557051-1	2015	The purpose of this study was to examine whether the replacement of the positively-charged Lys or Arg linker with a neutral linker could reduce the renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide.	Lysine	91-94	pro-opiomelanocortin-alpha	Mus musculus	193-229
27421841-1	2016	The X-linked lysine (K)-specific demethylase 5C (KDM5C) gene plays an important role in brain development and behavior.	Lysine	13-19	lysine (K)-specific demethylase 5C	Mus musculus	49-54
25652097-8	2015	Moreover, we report that the interplay between SUZ12 and JMJD3 results in dynamic regulation of lysine 27 trimethylation of histone 3 (H3K27me3).	Lysine	96-102	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	47-52
22585859-6	2012	In the death-inducing signaling complex, the C-terminal zinc finger (Znf) domain of the A20 ubiquitin ligase mediates receptor-interacting protein 1 polyubiquitination through lysine-63-linked polyubiquitin chains, which bind to the caspase-8 protease domain and inhibit caspase-8 dimerization, cleavage, and the initiation of TRAIL-induced apoptosis in glioblastoma-derived cell lines and tumor-initiating cells.	Lysine	176-182	caspase 8	Homo sapiens	233-242
22585859-6	2012	In the death-inducing signaling complex, the C-terminal zinc finger (Znf) domain of the A20 ubiquitin ligase mediates receptor-interacting protein 1 polyubiquitination through lysine-63-linked polyubiquitin chains, which bind to the caspase-8 protease domain and inhibit caspase-8 dimerization, cleavage, and the initiation of TRAIL-induced apoptosis in glioblastoma-derived cell lines and tumor-initiating cells.	Lysine	176-182	caspase 8	Homo sapiens	271-280
22117221-1	2012	Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown.	Lysine	64-70	lysine methyltransferase 5A	Homo sapiens	0-5
25830085-4	2015	The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1.	Lysine	14-20	insulin	Sus scrofa	113-120
25830085-4	2015	The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1.	Lysine	14-20	insulin like growth factor 1	Sus scrofa	125-153
22307598-8	2012	Hence, Lys(873), located in transmembrane segment M5 at a "hot spot" for cation binding in Ca(2+)-ATPase and Na(+),K(+)-ATPase, appears to participate directly in aminophospholipid binding or to mediate a crucial interaction within the ATP8A2-CDC50 complex.	Lysine	7-10	ATPase phospholipid transporting 8A2	Homo sapiens	236-242
27380996-3	2016	Aberrant lysine acetylation mediated by CBP/p300 has recently been implicated in the genesis of multiple hematologic cancers.	Lysine	9-15	E1A binding protein p300	Homo sapiens	44-48
22272736-2	2012	RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent antimicrobial activity, and is expressed in both normal and diseased skin; in contrast, the physiologic function of RNase 8 remains uncertain.	Lysine	52-58	ribonuclease A family member 8	Homo sapiens	0-7
22272736-2	2012	RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent antimicrobial activity, and is expressed in both normal and diseased skin; in contrast, the physiologic function of RNase 8 remains uncertain.	Lysine	52-58	ribonuclease A family member 7	Homo sapiens	34-41
27524613-5	2016	SNP rs539846 C&gt;A, the most highly associated variant (p = 1.42 x 10(-13), odds ratio = 1.35), localizes to a super-enhancer defined by extensive histone H3 lysine 27 acetylation in intron 3 of B cell lymphoma 2 (BCL2)-modifying factor (BMF).	Lysine	159-165	Bcl2 modifying factor	Homo sapiens	239-242
25785610-0	2015	Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.	Lysine	10-16	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	65-70
25786215-4	2015	Our detailed analysis clarified that this difference in dynamics was attributable to a difference in two basic amino acids in the alphaN helix; two arginine (Arg) residues in H3 were substituted by lysine (Lys) residues at the corresponding sites in CENP-A.	Lysine	206-209	centromere protein A	Homo sapiens	250-256
25786215-6	2015	Our exonuclease III assay consistently revealed that replacement of these two Arg residues in the H3 nucleosome by Lys enhanced endonuclease susceptibility, suggesting that the DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.	Lysine	115-118	centromere protein A	Homo sapiens	193-199
22139843-3	2012	To better understand turnover and identify potential sites of Cx43 ubiquitination, we prepared constructs of Cx43 with different lysines converted to arginines.	Lysine	129-136	gap junction protein alpha 1	Homo sapiens	109-113
26935174-4	2016	Furthermore, these tumors exhibit aberrant manganese superoxide dismutase (MnSOD) acetylation at lysine 68 and lysine 122 and have abnormally high reactive oxygen species (ROS) levels, which have been observed in many types of breast cancer.	Lysine	97-103	superoxide dismutase 2	Homo sapiens	43-73
22139843-4	2012	However, when transfected into cells, a mutant version of Cx43 with all lysines converted to arginines behaved similarly to wild type in the presence of proteasomal and lysosomal inhibitors, indicating that ubiquitination of Cx43 did not appear to be playing a role in gap junction stability.	Lysine	72-79	gap junction protein alpha 1	Homo sapiens	58-62
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	44-47	LOC222344	Homo sapiens	90-122
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	80-83	LOC222344	Homo sapiens	90-122
25727006-2	2015	We have discovered that CUL4A-RBX1-COPS8 E3 ligase activity is required for CENP-A ubiquitylation on lysine 124 (K124) and CENP-A centromere localization.	Lysine	101-107	centromere protein A	Homo sapiens	76-82
26935174-4	2016	Furthermore, these tumors exhibit aberrant manganese superoxide dismutase (MnSOD) acetylation at lysine 68 and lysine 122 and have abnormally high reactive oxygen species (ROS) levels, which have been observed in many types of breast cancer.	Lysine	97-103	superoxide dismutase 2	Homo sapiens	75-80
27177841-2	2016	The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (+-0.3) x 10(4) M(-1) s(-1) and 2.4 (+-0.3) x 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively.	Lysine	66-69	ADAM metallopeptidase domain 10	Homo sapiens	192-198
25750266-0	2015	HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity.	Lysine	27-33	histone deacetylase 3	Homo sapiens	0-5
21811504-2	2012	Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation.	Lysine	136-142	tet methylcytosine dioxygenase 2	Homo sapiens	70-74
27261007-3	2016	Mutants that suppress lys2-128  allow transcription from a normally inactive Ty1   promoter, conferring a LYS(+) phenotype.	Lysine	106-109	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	22-26
22356116-1	2012	We describe a Chinese woman who was assumed to be heterozygous for both Hb E [beta26(B8)Glu Lys] and alpha(0)-thalassemia (alpha(0)-thal) by a high performance liquid chromatography (HPLC) method, but was later also shown to be a Hb New York [beta113(G15)Val Glu] heterozygote by the Sebia CapillaryS2 system.	Lysine	92-95	hemoglobin subunit epsilon 1	Homo sapiens	72-76
25742135-6	2015	The BmANTI2 protein has an N-terminal extension in which the positions of lysine residues in the amino acid sequence are distributed as in human ANT4.	Lysine	74-80	ADP,ATP carrier protein-like	Bombyx mori	4-11
27462807-3	2016	RNF168 ubiquitinates H2A on lysine 13 and lysine 15 (refs 7, 8) (yielding H2AK13ub and H2AK15ub, respectively), an event that triggers the recruitment of 53BP1 (also known as TP53BP1) to chromatin flanking DSBs.	Lysine	28-34	ring finger protein 168	Homo sapiens	0-6
25664850-5	2015	Gain- and loss-of-function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, shifted the tumor stroma toward a high-HLCC, low-LCC state, increased tumor stiffness, and enhanced tumor cell invasion and metastasis.	Lysine	121-127	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	62-81
21922516-3	2012	Here we show that beta amyloid increases somatostatin and cortistatin gene expression mainly through an increase in histone 3 lysine 4 methylation (H3K4me3), a modification associated with transcriptional activation.	Lysine	126-132	cortistatin	Homo sapiens	58-69
27462807-3	2016	RNF168 ubiquitinates H2A on lysine 13 and lysine 15 (refs 7, 8) (yielding H2AK13ub and H2AK15ub, respectively), an event that triggers the recruitment of 53BP1 (also known as TP53BP1) to chromatin flanking DSBs.	Lysine	42-48	ring finger protein 168	Homo sapiens	0-6
25664850-5	2015	Gain- and loss-of-function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, shifted the tumor stroma toward a high-HLCC, low-LCC state, increased tumor stiffness, and enhanced tumor cell invasion and metastasis.	Lysine	121-127	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	83-86
22083954-5	2012	We provide the first evidence that HPL-1 interacts with HIS-24 monomethylated at lysine 14 (HIS-24K14me1) and associates in vivo with promoters of genes involved in antimicrobial response.	Lysine	81-87	Chromo domain-containing protein	Caenorhabditis elegans	35-40
27098889-3	2016	Data from recent research reports on the digestible lysine (dLys) requirements for maximum weight gain and minimum feed conversion ratio (FCR) were compiled from the literature.	Lysine	52-58	FCR	Gallus gallus	138-141
21933813-3	2012	Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail.	Lysine	156-162	ubiquitin protein ligase E3 component n-recognin 3	Homo sapiens	91-95
21933813-3	2012	Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail.	Lysine	156-162	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	139-143
25500897-0	2015	Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing.	Lysine	22-28	MHC class I antigen	Homo sapiens	72-91
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	222-228	CD40 antigen	Mus musculus	21-25
22679391-6	2012	We then show that p180 contains a lysine-rich region that can directly interact with RNA in vitro.	Lysine	34-40	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	18-22
25686248-5	2015	In mammalian cells, Huntingtin physically interacts with the autophagy cargo receptor p62 to facilitate its association with the integral autophagosome component LC3 and with Lys-63-linked ubiquitin-modified substrates.	Lysine	175-178	huntingtin	Homo sapiens	20-30
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	243-249	CD40 antigen	Mus musculus	21-25
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	243-249	CD40 antigen	Mus musculus	21-25
26896487-5	2016	We found that CD40 ligand expression is moderately induced by retroviral Thpok transduction into CD8(+) cytotoxic T cells, which was accompanied by a reduction of histone H3 lysine 9 methylation and histone H3 lysine 27 methylation in the promoter region of the Cd40lg gene.	Lysine	174-180	CD40 antigen	Mus musculus	14-18
25548288-3	2015	Little is known about how Bre1 directs Rad6 toward transferring only a single ubiquitin to a specific lysine residue.	Lysine	102-108	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	26-30
22905217-4	2012	Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression.	Lysine	26-33	cyclin D1	Homo sapiens	241-250
22905217-4	2012	Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression.	Lysine	26-33	basic helix-loop-helix family member e40	Homo sapiens	265-271
25548288-4	2015	Using a defined in vitro system, we show that the Bre1 RING domain interaction with Rad6 is minimally sufficient to monoubiquitinate nucleosomes at histone H2B Lys-123.	Lysine	160-163	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	50-54
26896487-5	2016	We found that CD40 ligand expression is moderately induced by retroviral Thpok transduction into CD8(+) cytotoxic T cells, which was accompanied by a reduction of histone H3 lysine 9 methylation and histone H3 lysine 27 methylation in the promoter region of the Cd40lg gene.	Lysine	210-216	CD40 antigen	Mus musculus	14-18
27268279-5	2016	We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells.	Lysine	21-27	lysine acetyltransferase 8	Homo sapiens	50-54
25561743-0	2015	A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45alpha mRNA stability.	Lysine	69-72	nucleolin	Homo sapiens	43-52
25561743-0	2015	A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45alpha mRNA stability.	Lysine	69-72	growth arrest and DNA damage inducible alpha	Homo sapiens	129-140
25561743-4	2015	In the studies reported here, we discovered SUMOylational modification of human nucleolin protein at Lys-294, which facilitated the mRNA binding property of nucleolin by maintaining its nuclear localization.	Lysine	101-104	nucleolin	Homo sapiens	80-89
22792191-3	2012	We confirmed in cellular assays that SIRT6 can deacetylate acetylated-histone H3 lysine 9 (H3K9Ac), however this deacetylase activity is unusually low in biochemical assays.	Lysine	81-87	sirtuin 6	Homo sapiens	37-42
27268279-5	2016	We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells.	Lysine	21-27	lysine acetyltransferase 8	Homo sapiens	111-115
25561743-4	2015	In the studies reported here, we discovered SUMOylational modification of human nucleolin protein at Lys-294, which facilitated the mRNA binding property of nucleolin by maintaining its nuclear localization.	Lysine	101-104	nucleolin	Homo sapiens	157-166
27235396-3	2016	Here, we report a novel Tat modification, monomethylation at lysine 71 (K71).	Lysine	61-67	tyrosine aminotransferase	Homo sapiens	24-27
25544292-6	2015	We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at the Stra6 RARE; 2) RA increases co-activator p300 (KAT3B) binding and histone H3 Lys-27 acetylation at both promoters; 3) RA decreases Suz12 levels and histone H3 Lys-27 trimethylation epigenetic marks at both promoters; and 4) these epigenetic changes are diminished in the absence of RARgamma.	Lysine	249-252	retinoid X receptor alpha	Mus musculus	62-70
22649767-4	2011	Mutation of the highly conserved SUMOylation residue lysine 249 significantly disrupts Aurora-A SUMOylation and mitotic defects characterized by defective and multipolar spindles ensue.	Lysine	53-59	aurora kinase A	Homo sapiens	87-95
27235396-4	2016	We found that Lys-71 monomethylation (K71me) is catalyzed by KMT7, a methyltransferase that also targets lysine 51 (K51) in Tat.	Lysine	14-17	tyrosine aminotransferase	Homo sapiens	124-127
22128329-4	2011	We now show that TRIM27 functions as an E3 ligase and mediates lysine 48 polyubiquitination of PI3KC2beta, leading to a decrease in PI3K enzyme activity.	Lysine	63-69	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	95-105
25654763-3	2015	Lys 109 within Fbxl7 is an essential acceptor site for ubiquitin conjugation by Fbxl18.	Lysine	0-3	F-box and leucine rich repeat protein 18	Homo sapiens	80-86
27235396-4	2016	We found that Lys-71 monomethylation (K71me) is catalyzed by KMT7, a methyltransferase that also targets lysine 51 (K51) in Tat.	Lysine	105-111	tyrosine aminotransferase	Homo sapiens	124-127
22079090-4	2011	Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TRbeta1 within the E2F1 gene promoter.	Lysine	36-42	E2F transcription factor 1 L homeolog	Xenopus laevis	198-202
27235396-5	2016	Using mass spectrometry, in vitro enzymology, and modification-specific antibodies, we found that KMT7 monomethylates both Lys-71 and Lys-51 in Tat.	Lysine	123-126	tyrosine aminotransferase	Homo sapiens	144-147
22079090-4	2011	Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TRbeta1 within the E2F1 gene promoter.	Lysine	36-42	E2F transcription factor 1 L homeolog	Xenopus laevis	228-232
25521393-5	2015	In samples treated at pressure below 400 MPa an insignificant increase of glycation level was observed, whereas high pressure (&gt;600 MPa) has only a minor effect on the number of hexose moieties (Fru) attached to the lysine residue side chain.	Lysine	219-225	zinc finger and BTB domain containing 22	Homo sapiens	198-201
22079090-4	2011	Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TRbeta1 within the E2F1 gene promoter.	Lysine	36-42	E2F transcription factor 1 L homeolog	Xenopus laevis	228-232
27235396-5	2016	Using mass spectrometry, in vitro enzymology, and modification-specific antibodies, we found that KMT7 monomethylates both Lys-71 and Lys-51 in Tat.	Lysine	134-137	tyrosine aminotransferase	Homo sapiens	144-147
27107943-8	2016	Further analysis revealed that WWP1 ubiquitinated mHtt at an atypical position of Lys-63, which may have inhibited degradation of mutant Htt through the ubiquitin-proteasome pathway.	Lysine	82-85	WW domain containing E3 ubiquitin protein ligase 1	Mus musculus	31-35
21855629-5	2011	Jak2 primarily contained K63-linked ubiquitin polymers, and mutation of this lysine blocked Jak2 ubiquitination and mobilization in WP1130-treated cells.	Lysine	77-83	Janus kinase 2	Homo sapiens	92-96
25451930-8	2015	Site-directed mutagenesis of Lys-85 and Thr-86 in helix 1 revealed that this interaction indeed determined ADRB1 activation kinetics.	Lysine	29-32	adrenoceptor beta 1	Homo sapiens	107-112
27154821-0	2016	ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.	Lysine	23-29	ASH1 like histone lysine methyltransferase	Homo sapiens	0-5
25529796-4	2015	Genetic deletion of Sirt1 increased mitochondrial superoxide dismutase 2 (Sod2) acetylation of lysine residue 68, thereby enhancing reactive oxygen species (ROS) production and reducing SOD2 activity.	Lysine	95-101	superoxide dismutase 2	Homo sapiens	74-78
27197174-5	2016	Enabled by a shotgun mass spectrometry analysis founded on tissue culture models, we identified a candidate SIRT2 deacetylation target at PKM2 lysine 305 (K305).	Lysine	143-149	pyruvate kinase, muscle	Mus musculus	138-142
26118199-0	2015	Interaction of Hb Grey Lynn (Vientiane) [alpha91(FG3)Leu&gt;Phe (alpha1)] with Hb E [beta26(B8) Glu&gt;Lys] and alpha(+)-thalassemia: Molecular and Hematological Analysis.	Lysine	103-106	hemoglobin subunit epsilon 1	Homo sapiens	79-83
22011814-4	2011	A non-synonymous single-nucleotide polymorphism at the amino-acid position of 267 in FUT8 (rs35949016; C/A, C allele=Thr, A allele=Lys) was genotyped in a total of 1149 consecutive autopsies of elderly Japanese.	Lysine	131-134	fucosyltransferase 8	Homo sapiens	85-89
22011814-9	2011	The FUT8 gene Thr267Lys polymorphism is associated with human PE, and the Lys allele is the risk.	Lysine	20-23	fucosyltransferase 8	Homo sapiens	4-8
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Lysine	20-26	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	73-77
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	cyclin G1	Homo sapiens	240-248
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	cyclin dependent kinase 2	Homo sapiens	253-257
25467431-4	2015	HPL-2 binding highly correlates with histone H3 mono- and dimethylated at lysine 9 (H3K9me1 and H3K9me2) and forms broad domains on autosomal arms.	Lysine	74-80	Chromo domain-containing protein	Caenorhabditis elegans	0-5
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Lysine	20-26	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	155-159
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Lysine	65-71	carbonic anhydrase 4	Rattus norvegicus	137-141
25355951-5	2015	Of interest, these effects were critically dependent on ubiquitination of the ECSIT lysine (K) 372 residue.	Lysine	84-90	ECSIT signaling integrator	Homo sapiens	78-83
25675367-4	2015	Indeed, DSBs induced in active genes, naturally enriched in the trimethyl form of histone H3 lysine 36 (H3K36me3), are channeled to repair by HR, in a manner depending on SETD2, the major H3K36 trimethyltransferase.	Lysine	93-99	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	171-176
21382104-7	2011	The predicted peptide, with two typical motifs of Trp-Cys-Gly-His-Cys-Lys (WCGHCK) which is a hallmark of the PDI family, has high homology to that of bovine (99.21%), human (95.05%), rat (89.50%) and mouse (90.89%).	Lysine	70-73	prolyl 4-hydroxylase subunit beta	Bos taurus	110-113
21931165-1	2011	CYLD is a lysine 63-deubiquitinating enzyme that inhibits NF-kappaB and JNK signaling.	Lysine	10-16	CYLD lysine 63 deubiquitinase	Mus musculus	0-4
21931165-4	2011	Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues.	Lysine	113-119	CYLD lysine 63 deubiquitinase	Mus musculus	29-33
21931165-4	2011	Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues.	Lysine	113-119	SMAD family member 7	Mus musculus	56-61
21931165-4	2011	Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues.	Lysine	113-119	CYLD lysine 63 deubiquitinase	Mus musculus	79-83
21931165-4	2011	Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues.	Lysine	113-119	SMAD family member 7	Mus musculus	104-109
25389294-2	2014	OSR1 is activated by with no lysine [K] (WNKs) kinases, and then it phosphorylates cation-coupled Cl-cotransporters, regulating ion homeostasis and cell volume in mammalian cells.	Lysine	29-35	oxidative stress responsive kinase 1	Homo sapiens	0-4
27193211-2	2016	Ub possesses seven lysine (K) residues (i.e., K6, K11, K27, K29, K33, K48, and K63) that can be used to form different chains based on different Ub linkage types (e.g., monoubiquitination/polyubiquitination).	Lysine	19-25	keratin 27	Homo sapiens	55-58
22086334-2	2011	Here we show that G9a or G9a-like protein (GLP) dimethylate the amino-terminal lysine 44 (K44) of mouse Dnmt3a (equivalent to K47 of human DNMT3A) in vitro and in cells overexpressing G9a or GLP.	Lysine	79-85	euchromatic histone methyltransferase 1	Mus musculus	25-41
22086334-2	2011	Here we show that G9a or G9a-like protein (GLP) dimethylate the amino-terminal lysine 44 (K44) of mouse Dnmt3a (equivalent to K47 of human DNMT3A) in vitro and in cells overexpressing G9a or GLP.	Lysine	79-85	euchromatic histone methyltransferase 1	Mus musculus	43-46
27298444-6	2016	G9a-dependent dimethylation of histone 3 lysine 9 (H3K9me2) is a repressive histone mark that is associated with gene silencing.	Lysine	41-47	euchromatic histone lysine N-methyltransferase 2	Mus musculus	0-3
22076378-8	2011	Thus, protein lysine succinylation may represent a posttranslational modification that can be reversed by Sirt5 in vivo.	Lysine	14-20	sirtuin 5	Homo sapiens	106-111
25423605-2	2014	The central chemical step in Lys 63-linked protein ubiquitination involves the reaction of a specific lysine on a target protein with Ub that is covalently attached as a thioester conjugate to the Ub conjugating enzyme (E2) Ubc13.	Lysine	29-32	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	224-229
25423605-2	2014	The central chemical step in Lys 63-linked protein ubiquitination involves the reaction of a specific lysine on a target protein with Ub that is covalently attached as a thioester conjugate to the Ub conjugating enzyme (E2) Ubc13.	Lysine	102-108	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	224-229
25423605-8	2014	In vivo functional complementation assays in yeast demonstrate that defects within this regulatory mechanism can have profound biological consequences, given that Ubc13 is the only E2 dedicated to synthesizing Lys 63-linked polyUb chains.	Lysine	210-213	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	163-168
27292644-2	2016	Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic activity of TGF-beta.	Lysine	20-26	transforming growth factor, beta 1	Mus musculus	103-111
21906649-6	2011	Modification of more than 70% of lysine residues from PspA (mPspA) did not interfere in the immune response as evaluated by the anti-PspA titer and C3 complement deposition assay.	Lysine	33-39	surfactant associated protein A1	Mus musculus	54-58
21906649-6	2011	Modification of more than 70% of lysine residues from PspA (mPspA) did not interfere in the immune response as evaluated by the anti-PspA titer and C3 complement deposition assay.	Lysine	33-39	surfactant associated protein A1	Mus musculus	60-65
27315556-5	2016	Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impairs the interaction with the mRNA decay factors DCP2, EDC4, and XRN1, but not EDC3, thus remodeling P-body architecture.	Lysine	27-34	enhancer of mRNA decapping 4	Homo sapiens	136-140
25318671-6	2014	Nevertheless, only Sox10 histone H3 lysine 36 dimethylation requires NSD3, revealing unexpected complexity in NSD3-dependent neural crest gene regulation.	Lysine	36-42	nuclear receptor binding SET domain protein 3	Homo sapiens	69-73
25423098-4	2014	Multiple reaction monitoring (MRM) mass spectroscopy was used to assess changes in relative phosphorylation on 18 of 23 serine and threonine residues and sumoylation on one of two lysine resides in BCL11B.	Lysine	180-186	B cell leukemia/lymphoma 11B	Mus musculus	198-204
27302742-5	2016	Using an immunoprecipitation assay, we revealed that ubiquitin molecule was directly conjugated to Chac1, and that mutated Chac1 with all lysine residues replaced by arginine was also ubiquitinated.	Lysine	138-144	ChaC, cation transport regulator 1	Mus musculus	123-128
25382779-0	2014	Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.	Lysine	0-6	SET and MYND domain containing 3	Homo sapiens	30-35
21946435-2	2011	Here we report that CYLD, a deubiquitinase that specifically digests lysine 63-linked ubiquitin chains, is required for antiviral host defense.	Lysine	69-75	CYLD lysine 63 deubiquitinase	Mus musculus	20-24
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	RNA exonuclease 1 homolog	Homo sapiens	220-224
21532618-5	2011	EZH2 represses rap1GAP by facilitating the trimethylation of histone 3 at lysine 27, a mark of gene repression, and also hypermethylation of rap1GAP promoter.	Lysine	74-80	RAP1 GTPase activating protein	Homo sapiens	15-22
25220405-2	2014	In the heart, enhancement of lysine acetylation or SUMOylation using histone deacetylase (HDAC) inhibitors or SUMO-1 gene transfer, respectively, has been shown to be cardioprotective.	Lysine	29-35	small ubiquitin like modifier 1	Homo sapiens	110-116
25220405-9	2014	These findings reveal a novel role for reversible lysine acetylation in the control of SUMOylation in the heart, and suggest that cardioprotective actions of HDAC inhibitors are in part due to stimulation of protein SUMO-1-ylation in myocytes and fibroblasts.	Lysine	50-56	small ubiquitin like modifier 1	Homo sapiens	216-222
21516122-6	2011	We found that the small ubiquitin-related modifier (SUMO) motif (SM) at lysine 568 (VKAE) adjacent to the CIM was necessary to obtain the maximum transcriptional repressor activity of MEL1S.	Lysine	72-78	PR/SET domain 16	Homo sapiens	184-189
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	Sp7 transcription factor	Homo sapiens	250-253
26992901-7	2016	Results showed that ALDH2 Glu/Lys was associated with a significantly increased risk of BCa compared with Glu/Glu (OR 2.03, 95% CI 1.14-3.62, P = 0.017).	Lysine	30-33	aldehyde dehydrogenase 2 family member	Homo sapiens	20-25
21798734-5	2011	These involve promoting Forkhead box p3 (Foxp3) gene expression and preserving Foxp3 lysine e-acetylation, which infers resistance to ubiquitination and proteasomal degradation, and increases DNA binding.	Lysine	85-91	forkhead box P3	Homo sapiens	79-84
25554733-1	2014	SETD8 (also known as SET8, PR-SET7, or KMT5A (lysine methyltransferase 5A)) is the only known lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).	Lysine	46-52	lysine methyltransferase 5A	Homo sapiens	0-5
25554733-1	2014	SETD8 (also known as SET8, PR-SET7, or KMT5A (lysine methyltransferase 5A)) is the only known lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).	Lysine	46-52	lysine methyltransferase 5A	Homo sapiens	21-25
25554733-1	2014	SETD8 (also known as SET8, PR-SET7, or KMT5A (lysine methyltransferase 5A)) is the only known lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).	Lysine	46-52	lysine methyltransferase 5A	Homo sapiens	27-34
25554733-1	2014	SETD8 (also known as SET8, PR-SET7, or KMT5A (lysine methyltransferase 5A)) is the only known lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).	Lysine	46-52	lysine methyltransferase 5A	Homo sapiens	39-44
22028615-7	2011	WHSC1 interacts with some proteins related to the WNT pathway including beta-catenin and transcriptionally regulates CCND1, the target gene of the beta-catenin/Tcf-4 complex, through histone H3 at lysine 36 trimethylation.	Lysine	197-203	cyclin D1	Homo sapiens	117-122
27117573-0	2016	A New delta-Globin Gene Variant: Hb A2-Fengshun [delta121(GH4)Glu Lys (HBD: c.364G &gt; A)].	Lysine	66-69	hemoglobin subunit alpha 1	Homo sapiens	6-18
21757742-8	2011	We also found that Tyk2 is preferentially Lys-63 polyubiquitinated and that this activation reaction is inhibited by SOCS1.	Lysine	42-45	tyrosine kinase 2	Homo sapiens	19-23
27117573-0	2016	A New delta-Globin Gene Variant: Hb A2-Fengshun [delta121(GH4)Glu Lys (HBD: c.364G &gt; A)].	Lysine	66-69	hemoglobin subunit alpha 2	Homo sapiens	33-38
27117573-3	2016	In this report, we describe a novel missense mutation of the delta-globin [Hb A2-Fengshun or delta121(GH4)Glu Lys, HBD: c.364G &gt; A] in a Chinese individual who had coinherited a heterozygous beta-thal with a normal Hb A2 level.	Lysine	110-113	hemoglobin subunit alpha 1	Homo sapiens	61-73
25201174-1	2014	Abnormally high transcription of the glial cell-line derived neurotrophic factor (gdnf) gene in glioma cells is related to the hyperacetylation of histone H3 lysine 9 (H3K9) in its promoter region II, but the mechanism remains unclear.	Lysine	158-164	glial cell derived neurotrophic factor	Rattus norvegicus	37-80
25201174-1	2014	Abnormally high transcription of the glial cell-line derived neurotrophic factor (gdnf) gene in glioma cells is related to the hyperacetylation of histone H3 lysine 9 (H3K9) in its promoter region II, but the mechanism remains unclear.	Lysine	158-164	glial cell derived neurotrophic factor	Rattus norvegicus	82-86
21791417-3	2011	Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential.	Lysine	39-45	plasminogen	Homo sapiens	80-87
21791417-3	2011	Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential.	Lysine	39-45	plasminogen	Homo sapiens	207-214
27117573-3	2016	In this report, we describe a novel missense mutation of the delta-globin [Hb A2-Fengshun or delta121(GH4)Glu Lys, HBD: c.364G &gt; A] in a Chinese individual who had coinherited a heterozygous beta-thal with a normal Hb A2 level.	Lysine	110-113	hemoglobin subunit alpha 2	Homo sapiens	75-80
27117573-3	2016	In this report, we describe a novel missense mutation of the delta-globin [Hb A2-Fengshun or delta121(GH4)Glu Lys, HBD: c.364G &gt; A] in a Chinese individual who had coinherited a heterozygous beta-thal with a normal Hb A2 level.	Lysine	110-113	hemoglobin subunit alpha 2	Homo sapiens	218-223
21757724-7	2011	Using chromatin immunoprecipitation, we demonstrated that IRF-1 binds to the 5" TG promoter motif, and the transcription factor binding correlates with active chromatin structure and is marked by enrichment of mono-methylated Lys-4 residue of histone H3, a signature of active transcriptional enhancers.	Lysine	226-229	thyroglobulin	Homo sapiens	80-82
27232889-7	2016	Ube3a was associated with and specifically ubiquitinated lysine 227 within the cytoplasmic tail of Tkv, and promoted its proteasomal degradation in Schneider 2 cells.	Lysine	57-63	thickveins	Drosophila melanogaster	99-102
21737840-9	2011	The facilitation of GGR is achieved through enabling monoubiquitination of histone H2B lysine 123 by Bre1, which in turn permits di- and trimethylation of histone H3 lysine 79 by Dot1.	Lysine	87-93	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	101-105
21737840-9	2011	The facilitation of GGR is achieved through enabling monoubiquitination of histone H2B lysine 123 by Bre1, which in turn permits di- and trimethylation of histone H3 lysine 79 by Dot1.	Lysine	166-172	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	101-105
25327705-3	2014	As a phospholipase D superfamily member Tdp1 utilizes two catalytic histidines each within a His-Lys-Asn motif.	Lysine	97-100	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	40-44
27178468-4	2016	It required linear polyubiquitination of two specific lysine residues of IRF-3 by LUBAC, the linear polyubiquitinating enzyme complex, which bound IRF-3 in signal-dependent fashion.	Lysine	54-60	interferon regulatory factor 3	Mus musculus	73-78
25172766-6	2014	The ubiquitination of Ptr2 most likely occurs at the N-terminal lysines 16, 27, and 34.	Lysine	64-71	Ptr2p	Saccharomyces cerevisiae S288C	22-26
25172766-7	2014	Simultaneous substitution of arginine for the three lysines fully prevented Ptr2 degradation.	Lysine	52-59	Ptr2p	Saccharomyces cerevisiae S288C	76-80
21898163-1	2011	The two new synthetic analogues of the MBP(83-99) epitope substituted at Lys(91) (primary TCR contact) with Phe [MBP(83-99) (Phe(91))] or Tyr [MBP(83-99) (Tyr(91))], have been structurally elucidated using 1D and 2D high resolution NMR studies.	Lysine	73-76	myelin basic protein	Homo sapiens	39-42
21642393-7	2011	Comparative modeling with OATP1A2 and OATP2B1 revealed that the pore size around this lysine residue is larger in OATP1A2 and smaller in OATP2B1 compared with OATP1B3, which could be related to the respective substrate spectra.	Lysine	86-92	solute carrier organic anion transporter family member 1A2	Homo sapiens	26-33
21642393-7	2011	Comparative modeling with OATP1A2 and OATP2B1 revealed that the pore size around this lysine residue is larger in OATP1A2 and smaller in OATP2B1 compared with OATP1B3, which could be related to the respective substrate spectra.	Lysine	86-92	solute carrier organic anion transporter family member 1A2	Homo sapiens	114-121
27178468-4	2016	It required linear polyubiquitination of two specific lysine residues of IRF-3 by LUBAC, the linear polyubiquitinating enzyme complex, which bound IRF-3 in signal-dependent fashion.	Lysine	54-60	interferon regulatory factor 3	Mus musculus	147-152
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	E1A binding protein p300	Homo sapiens	77-81
25070368-4	2014	In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH.	Lysine	57-63	gap junction protein alpha 1	Homo sapiens	35-39
25070368-4	2014	In this study, we demonstrate that Cx43 is modified with lysine 63-linked polyubiquitin chains and that these increase the interaction between Cx43 and AMSH.	Lysine	57-63	gap junction protein alpha 1	Homo sapiens	143-147
25204660-2	2014	PHF2 and PHF8 belong to a subfamily of histone demethylases that also possess a PHD domain-dependent di-/trimethylated histone 3 lysine 4 (H3K4me2/3) binding activity and are known to be enriched in the nucleolus.	Lysine	129-135	PHD finger protein 8	Homo sapiens	9-13
24990321-7	2014	PAR-4-mediated induction of COX-2 was prevented by the PI3K inhibitor LY (10 muM).	Lysine	70-72	Prader Willi/Angelman region RNA 4	Homo sapiens	0-5
24981246-1	2014	Heterochromatin protein 1gamma (HP1gamma), which binds to di- or trimethylated lysine 9 on histone H3 (H3K9), plays an important role in chromatin packaging and gene transcriptional regulation.	Lysine	79-85	chromobox 3	Homo sapiens	0-30
24981246-1	2014	Heterochromatin protein 1gamma (HP1gamma), which binds to di- or trimethylated lysine 9 on histone H3 (H3K9), plays an important role in chromatin packaging and gene transcriptional regulation.	Lysine	79-85	chromobox 3	Homo sapiens	32-40
25267112-3	2014	Here we show that Jumonji-C domain-containing protein JMJ30 directly binds to the flowering-repressor FLOWERING LOCUS C (FLC) locus and removes the repressive histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	183-189	2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein	Arabidopsis thaliana	54-59
25211074-4	2014	This NS5-STAT2 interaction requires IFN-I-induced tyrosine phosphorylation of STAT1 and the K63-linked polyubiquitination at a lysine in the N-terminal region of YFV NS5.	Lysine	127-133	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	5-8
25211074-4	2014	This NS5-STAT2 interaction requires IFN-I-induced tyrosine phosphorylation of STAT1 and the K63-linked polyubiquitination at a lysine in the N-terminal region of YFV NS5.	Lysine	127-133	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	166-169
25139236-6	2014	Interestingly, cIAP1 was capable of ubiquitinating EndoG in the presence of wild-type and mutant Ubiquitin, in which all lysines except K63 were mutated to arginine.	Lysine	121-128	baculoviral IAP repeat containing 2	Homo sapiens	15-20
25185200-0	2014	53BP1 regulates pRB via a lysine methylation-dependent interaction.	Lysine	26-32	RB transcriptional corepressor 1	Homo sapiens	16-19
25019367-4	2014	During osteogenic differentiation of BMSCs, pharmacological inhibition of HDAC8 by HDAC inhibitor valproic acid (VPA) promoted the level of histone H3 lysine 9 acetylation (H3K9Ac) and significantly enhanced the expression of osteogenesis-related genes Runx2, Osterix, osteocalcin (OCN), osteopontin (OPN) and alkaline phosphatase (ALP).	Lysine	151-157	histone deacetylase 8	Rattus norvegicus	74-79
24733520-4	2014	Factor acetyltransferase p300 (FATp300), a major epigenetic regulator that acetylates specific lysines in histones and transcription factors, is essential for elevated collagen synthesis and the levels of FATp300 are significantly elevated in different fibrotic tissues.	Lysine	95-102	E1A binding protein p300	Homo sapiens	25-29
25156493-4	2014	ArhGAP30 binds to p53 C-terminal domain and P300, facilitating P300-mediated acetylation of p53 at lysine 382.	Lysine	99-105	Rho GTPase activating protein 30	Homo sapiens	0-8
25337216-5	2014	Knockdown of PTPRU also inhibits tyrosine phosphorylation and transcriptional activity of beta-catenin as well as levels of focal adhesion proteins and lysine methylation of histone H3.	Lysine	152-158	protein tyrosine phosphatase receptor type U	Homo sapiens	13-18
24980959-7	2014	RNF2 mediates ubiquitination of AMBRA1 at lysine 45.	Lysine	42-48	ring finger protein 2	Homo sapiens	0-4
25082344-3	2014	Stable repression of these domains depends on Polycomb Group (PcG) functions, which include trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	110-116	Polycomb	Drosophila melanogaster	46-60
25082344-3	2014	Stable repression of these domains depends on Polycomb Group (PcG) functions, which include trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	110-116	Polycomb	Drosophila melanogaster	62-65
24971742-1	2014	The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-KDM4D), which selectively remove the methyl group(s) from tri/dimethylated lysine 9/36 of H3, modulate transcriptional activation and genome stability.	Lysine	44-50	lysine demethylase 4D	Homo sapiens	71-76
32261565-0	2014	Controlling the biointerface of electrospun mats for clot lysis: an engineered tissue plasminogen activator link to a lysine-functionalized surface.	Lysine	118-124	plasminogen activator, tissue	Mus musculus	79-107
32261565-5	2014	A highly specific tethering of t-PA was facilitated by the lysine-functionalized surface through molecular recognition of t-PA to the lysine ligands.	Lysine	59-65	plasminogen activator, tissue	Mus musculus	31-35
32261565-5	2014	A highly specific tethering of t-PA was facilitated by the lysine-functionalized surface through molecular recognition of t-PA to the lysine ligands.	Lysine	59-65	plasminogen activator, tissue	Mus musculus	122-126
32261565-5	2014	A highly specific tethering of t-PA was facilitated by the lysine-functionalized surface through molecular recognition of t-PA to the lysine ligands.	Lysine	134-140	plasminogen activator, tissue	Mus musculus	31-35
32261565-5	2014	A highly specific tethering of t-PA was facilitated by the lysine-functionalized surface through molecular recognition of t-PA to the lysine ligands.	Lysine	134-140	plasminogen activator, tissue	Mus musculus	122-126
32261565-6	2014	Moreover, the t-PA anchorage to the PVA/PVA-Lys mats can be easily released by plasminogen displacement when exposed to plasma, and can efficiently lyse the formed-clot in an in vitro plasma assay.	Lysine	44-47	plasminogen activator, tissue	Mus musculus	14-18
32261565-7	2014	In particular, the quantities of t-PA tethered on the mats could easily be regulated by simply varying the blend ratio of PVA and PVA-Lys in the electrospinning process.	Lysine	134-137	plasminogen activator, tissue	Mus musculus	33-37
24806961-1	2014	In human cells, appropriate monomethylation of histone H4 lysine 20 by PrSet7 (also known as SET8 and SETD7) is important for the correct transcription of specific genes and timely progression through the cell cycle.	Lysine	58-64	lysine methyltransferase 5A	Homo sapiens	71-77
24806961-1	2014	In human cells, appropriate monomethylation of histone H4 lysine 20 by PrSet7 (also known as SET8 and SETD7) is important for the correct transcription of specific genes and timely progression through the cell cycle.	Lysine	58-64	lysine methyltransferase 5A	Homo sapiens	93-97
24935251-6	2014	Histone acetylation (primary MoA) increased quickly and returned to baseline after 48 h. Histone H3 lysine methylation at the promoter of the neurodevelopmental regulators PAX6 or OTX2 was increasingly altered over time.	Lysine	100-106	paired box 6	Homo sapiens	172-176
24571482-10	2014	MOF/hMOF physically interacted with and acetylated Nrf2 at Lys(588) .	Lysine	59-62	lysine acetyltransferase 8	Homo sapiens	0-3
24571482-10	2014	MOF/hMOF physically interacted with and acetylated Nrf2 at Lys(588) .	Lysine	59-62	lysine acetyltransferase 8	Homo sapiens	4-8
24899502-4	2014	Moreover, acetylation of histone 3 lysine 9 (H3K9), a critical feature of the active promoter state that is opposed by histone 3 lysine 9 trimethylation, was significantly increased and was essentially mediated by the p300-histone acetyltransferase.	Lysine	35-41	E1A binding protein p300	Homo sapiens	218-222
24899502-4	2014	Moreover, acetylation of histone 3 lysine 9 (H3K9), a critical feature of the active promoter state that is opposed by histone 3 lysine 9 trimethylation, was significantly increased and was essentially mediated by the p300-histone acetyltransferase.	Lysine	129-135	E1A binding protein p300	Homo sapiens	218-222
24682716-0	2014	Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo.	Lysine	52-58	histone acetyltransferase 1	Homo sapiens	6-33
24682716-0	2014	Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo.	Lysine	52-58	histone acetyltransferase 1	Homo sapiens	35-39
24971881-3	2014	In these cells, SUMO1 modification occurred on both lysine 75 and lysine 9 of SOD1, and modification of ALS-linked SOD1 mutant proteins by SUMO3, rather than by SUMO1, significantly increased the stability of the proteins and accelerated intracellular aggregate formation.	Lysine	52-58	small ubiquitin like modifier 1	Homo sapiens	16-21
24971881-3	2014	In these cells, SUMO1 modification occurred on both lysine 75 and lysine 9 of SOD1, and modification of ALS-linked SOD1 mutant proteins by SUMO3, rather than by SUMO1, significantly increased the stability of the proteins and accelerated intracellular aggregate formation.	Lysine	66-72	small ubiquitin like modifier 1	Homo sapiens	16-21
24847881-0	2014	SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.	Lysine	12-18	SET and MYND domain containing 3	Homo sapiens	0-5
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	SET and MYND domain containing 3	Homo sapiens	22-27
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	zinc fingers and homeoboxes 2	Homo sapiens	107-110
24910128-2	2014	Here we elucidate a DSB repair function for transcription-coupled Set2 methylation at H3 lysine 36 (H3K36me).	Lysine	89-95	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	66-70
24890512-2	2014	The bromodomain-containing proteins of the BET family, which recognize histone lysine acetylation, play a key role in the transcriptional control of inflammatory genes.	Lysine	79-85	delta/notch like EGF repeat containing	Homo sapiens	43-46
24519555-8	2014	CONCLUSION: The GLP-1 receptor antagonist exendin(9-39) labelled with (125)I-BH at lysine 19 is an excellent GLP-1 radioligand that identifies human and rat GLP-1 receptors in normal and tumoural tissues.	Lysine	83-89	glucagon like peptide 1 receptor	Homo sapiens	16-30
24633887-1	2014	The suppressor of zeste-12 protein (SUZ12), a core component of Polycomb repressive complex 2 (PRC2), is implicated in transcriptional silencing by generating di- and tri-methylation of lysine 27 on histone H3 (H3K27Me3).	Lysine	186-192	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	36-41
24662292-7	2014	The Pex10p Pex12p complex catalyzes monoubiquitination of Pex5p at one of multiple lysine residues in vitro, following the dissociation of Pex5p from Pex14p and the PTS1 cargo.	Lysine	83-89	peroxisomal biogenesis factor 5	Homo sapiens	58-63
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Lysine	31-37	peroxisomal biogenesis factor 5	Homo sapiens	61-66
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Lysine	31-37	peroxisomal biogenesis factor 5	Homo sapiens	126-131
24843002-2	2014	In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand breaks (DSBs).	Lysine	76-82	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	28-33
24435446-1	2014	The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2.	Lysine	100-107	delta/notch like EGF repeat containing	Homo sapiens	36-39
24239489-5	2014	STUDY DESIGN: An experimental study investigating the phosphorylation profile of an important Cl-regulatory protein Na+-K+-Cl- cotransporter 1 (NKCC1) and its regulatory-kinase WNK1 (kinase with-no-lysine).	Lysine	198-204	solute carrier family 12 member 2	Rattus norvegicus	116-142
24239489-5	2014	STUDY DESIGN: An experimental study investigating the phosphorylation profile of an important Cl-regulatory protein Na+-K+-Cl- cotransporter 1 (NKCC1) and its regulatory-kinase WNK1 (kinase with-no-lysine).	Lysine	198-204	solute carrier family 12 member 2	Rattus norvegicus	144-149
24140279-3	2014	Recently, it was found that Kin17 is methylated on lysine 135 by the newly discovered methyltransferase METTL22.	Lysine	51-57	Kin17 DNA and RNA binding protein	Homo sapiens	28-33
24140279-11	2014	Functional experiments uncover a correlative role between Kin17 lysine methylation and its association with chromatin.	Lysine	64-70	Kin17 DNA and RNA binding protein	Homo sapiens	58-63
24703693-0	2014	Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.	Lysine	0-6	sirtuin 5	Mus musculus	78-83
24478033-7	2014	Treatment with carboxypeptidase B to assess the roles of carboxyl-terminal lysines in cellular receptors leads in most cases to decreases in plasminogen activation as well as plasminogen and apo(a) binding; however, inhibition of plasminogen activation by apo(a) was unaffected.	Lysine	75-82	lipoprotein(a)	Homo sapiens	191-197
24423864-2	2014	We unexpectedly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also dependent on PR-Set7, but independent of its catalytic activity.	Lysine	84-90	lysine methyltransferase 5A	Homo sapiens	126-133
24474444-0	2014	Ratio of lysine to methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells.	Lysine	9-15	mechanistic target of rapamycin kinase	Bos taurus	116-120
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	59-65	Janus kinase 2	Homo sapiens	190-194
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	82-85	Janus kinase 2	Homo sapiens	190-194
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	casein alpha s1	Homo sapiens	31-37
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	casein kappa	Homo sapiens	53-57
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	Janus kinase 2	Homo sapiens	66-70
24616512-4	2014	A point mutation in an evolutionarily conserved lysine-rich domain encoded by the alternatively spliced Zfp318 exon 10 abolished IgD expression on marginal zone B cells, decreased IgD on follicular B cells, and increased IgM, but only slightly decreased the percentage of B cells and did not decrease expression of other maturation markers CD21, CD23, or CD62L.	Lysine	48-54	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	346-350
24656127-4	2014	In this Perspective, we will discuss recent findings in the identification of cancer-related enhancer mutations and the role of Drosophila Trr and its human homologs, the MLL3 and MLL4/COMPASS-like complexes, as enhancer histone H3 lysine 4 (H3K4) monomethyltransferases functioning in enhancer-promoter communication.	Lysine	232-238	trithorax-related	Drosophila melanogaster	139-142
24656127-4	2014	In this Perspective, we will discuss recent findings in the identification of cancer-related enhancer mutations and the role of Drosophila Trr and its human homologs, the MLL3 and MLL4/COMPASS-like complexes, as enhancer histone H3 lysine 4 (H3K4) monomethyltransferases functioning in enhancer-promoter communication.	Lysine	232-238	lysine methyltransferase 2B	Homo sapiens	180-184
24459145-5	2014	Here, we demonstrate that PR-SET7/SETD8, which monomethylates histone H4 lysine 20 (H4K20me1), controls both H4K16Ac and H4K20me3 and in doing so, regulates Pol II pausing dynamics.	Lysine	73-79	lysine methyltransferase 5A	Homo sapiens	26-33
24459145-5	2014	Here, we demonstrate that PR-SET7/SETD8, which monomethylates histone H4 lysine 20 (H4K20me1), controls both H4K16Ac and H4K20me3 and in doing so, regulates Pol II pausing dynamics.	Lysine	73-79	lysine methyltransferase 5A	Homo sapiens	34-39
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Lysine	142-148	lysine permease	Saccharomyces cerevisiae S288C	96-100
24448798-7	2014	We show that the single substitution T456S results in a Can1 variant transporting lysine in addition to arginine and that the combined substitutions T456S and S176N convert Can1 to a Lyp1-like permease.	Lysine	82-88	lysine permease	Saccharomyces cerevisiae S288C	183-187
24583395-2	2014	Lysine(K)-specific demethylase 5C (KDM5C) is a versatile epigenetic regulator that removes di- and tri-methyl groups of lysine 4 on histone H3 (H3K4) from transcriptional targets and is essential for neuronal survival and dendritic growth.	Lysine	120-126	lysine demethylase 5C	Homo sapiens	0-33
24583395-2	2014	Lysine(K)-specific demethylase 5C (KDM5C) is a versatile epigenetic regulator that removes di- and tri-methyl groups of lysine 4 on histone H3 (H3K4) from transcriptional targets and is essential for neuronal survival and dendritic growth.	Lysine	120-126	lysine demethylase 5C	Homo sapiens	35-40
24374040-4	2014	Two polymorphisms of LMP2-60 (Arg His) and LMP7-145 (Gln Lys) were identified by PCR-RFLP (RFLP, restriction fragment length polymorphism) method.	Lysine	57-60	proteasome 20S subunit beta 8	Homo sapiens	43-47
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	E1A binding protein p300	Homo sapiens	181-185
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	E1A binding protein p300	Homo sapiens	181-185
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	E1A binding protein p300	Homo sapiens	15-19
21808001-4	2011	Next, MSK1 and Elk-1 activation evoked serine-10 phosphorylation and lysine-14 acetylation in histone H3, resulting in the induction of the neuroplasticity-associated immediate-early genes c-Fos and Egr-1 in these neurons.	Lysine	69-75	ribosomal protein S6 kinase A5	Homo sapiens	6-10
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	113-116	ring finger protein 2	Homo sapiens	0-4
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	113-116	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	5-9
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	113-116	H2A.X variant histone	Homo sapiens	25-29
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	113-116	H2A.X variant histone	Homo sapiens	105-109
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	122-125	ring finger protein 2	Homo sapiens	0-4
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	122-125	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	5-9
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	122-125	H2A.X variant histone	Homo sapiens	25-29
21676867-5	2011	RNF2-BMI1 interacts with H2AX in a DNA damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).	Lysine	122-125	H2A.X variant histone	Homo sapiens	105-109
21653697-6	2011	Calnuc binding was impaired when Lys-248 in the alpha3 helix of Galpha(i3) was replaced with M, the corresponding residue in Galpha(o), which does not bind to Calnuc.	Lysine	33-36	nucleobindin 1	Homo sapiens	0-6
21653697-6	2011	Calnuc binding was impaired when Lys-248 in the alpha3 helix of Galpha(i3) was replaced with M, the corresponding residue in Galpha(o), which does not bind to Calnuc.	Lysine	33-36	brain protein I3	Homo sapiens	64-73
21764752-0	2011	The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.	Lysine	62-68	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	28-31
21541786-1	2011	Alternative lysine and methionine residues at position 44 in the D1 domain determine the specificities of human lineage III killer cell immunoglobulin-like receptors (KIR) for the C1 and C2 epitopes of HLA-C.	Lysine	12-18	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	167-170
21497669-0	2011	C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII.	Lysine	19-22	coagulation factor VIII	Homo sapiens	93-116
21847359-7	2011	Importantly, we show that EHMT2 can suppress transcription of the SIAH1 gene by binding to its promoter region (-293 to +51) and by methylating lysine 9 of histone H3.	Lysine	144-150	siah E3 ubiquitin protein ligase 1	Homo sapiens	66-71
21876682-5	2011	First, functional loss of key epigenetic genes-including METHYLTRANSFERASE1 (MET1) encoding for DNA methyltransferase, KRYPTONITE (KYP) for the histone 3 lysine 9 (H3K9) methyltransferase, JMJ14 for the histone 3 lysine 4 (H3K4) demethylase, and HAC1 for the histone acetyltransferase-resulted in altered WUS expression and developmental rates of regenerated shoots in vitro.	Lysine	154-160	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	119-129
21565207-2	2011	In this paper, we aimed to investigate whether the entire MafA protein has the self-delivery activity, and that the arginine- and lysine-rich sequence in MafA bZIP domain is an efficient protein transduction domain (PTD).	Lysine	130-136	MAF bZIP transcription factor A	Rattus norvegicus	58-62
21565207-2	2011	In this paper, we aimed to investigate whether the entire MafA protein has the self-delivery activity, and that the arginine- and lysine-rich sequence in MafA bZIP domain is an efficient protein transduction domain (PTD).	Lysine	130-136	MAF bZIP transcription factor A	Rattus norvegicus	154-158
21726812-4	2011	Here we focus on the TGF-beta superfamily transcriptional repressor TIF1gamma/TRIM33/Ectodermin and demonstrate that its PHD finger-bromodomain constitutes a multivalent histone-binding module that specifically binds histone H3 tails unmethylated at K4 and R2 and acetylated at two key lysines.	Lysine	286-293	tripartite motif containing 33	Homo sapiens	68-77
21726812-4	2011	Here we focus on the TGF-beta superfamily transcriptional repressor TIF1gamma/TRIM33/Ectodermin and demonstrate that its PHD finger-bromodomain constitutes a multivalent histone-binding module that specifically binds histone H3 tails unmethylated at K4 and R2 and acetylated at two key lysines.	Lysine	286-293	tripartite motif containing 33	Homo sapiens	78-84
21600186-3	2011	To examine the contribution of each active site to the enzymatic activity of ALAS/ALAS, the catalytic lysine, which also covalently binds the PLP cofactor, was substituted with alanine in one of the active sites.	Lysine	102-108	pyridoxal phosphatase	Homo sapiens	142-145
21402151-3	2011	TRPC7 contains three putative cGK phosphorylation sites (Arg-Arg/Lys-Xaa-Ser/Thr).	Lysine	65-68	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	0-5
21406197-10	2011	), an inhibitor that blocks the high-affinity lysine binding sites of both plasminogen and plasmin.	Lysine	46-52	plasminogen	Homo sapiens	75-82
21427083-6	2011	Chromatin immunoprecipitation revealed that the miR-423-5p mimic decreased RNA polymerase II occupancy and increased histone H3 lysine 9 dimethylation (H3K9me2) at the PR promoter, indicative of chromatin-level silencing.	Lysine	128-134	progesterone receptor	Homo sapiens	168-170
21680843-4	2011	Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.	Lysine	155-161	sirtuin 6	Homo sapiens	26-31
21608095-1	2011	Biotin protein ligase (BPL) mediates the covalent attachment of biotin to a specific lysine residue of biotin carboxyl carrier protein (BCCP).	Lysine	85-91	holocarboxylase synthetase	Homo sapiens	0-21
21608095-1	2011	Biotin protein ligase (BPL) mediates the covalent attachment of biotin to a specific lysine residue of biotin carboxyl carrier protein (BCCP).	Lysine	85-91	holocarboxylase synthetase	Homo sapiens	23-26
21666679-4	2011	Here we identify ADD(ATRX) as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3).	Lysine	107-113	ATRX chromatin remodeler	Homo sapiens	21-25
21666679-4	2011	Here we identify ADD(ATRX) as a previously unknown histone H3-binding module, whose binding is promoted by lysine 9 trimethylation (H3K9me3) but inhibited by lysine 4 trimethylation (H3K4me3).	Lysine	158-164	ATRX chromatin remodeler	Homo sapiens	21-25
21566644-3	2011	Here, we report that SOD2 is acetylated at Lys 68 and that this acetylation decreases SOD2 activity.	Lysine	43-46	superoxide dismutase 2	Homo sapiens	21-25
21566644-3	2011	Here, we report that SOD2 is acetylated at Lys 68 and that this acetylation decreases SOD2 activity.	Lysine	43-46	superoxide dismutase 2	Homo sapiens	86-90
21511880-6	2011	Transient recruitment of the histone acetyl transferase complex cAMP response element-binding protein (CREB) binding protein (CBP)/p300 is found to precisely track the ultradian hormone rhythm, resulting in transient localized net changes in lysine acetylation at GC-regulatory regions after each pulse.	Lysine	242-248	E1A binding protein p300	Homo sapiens	131-135
26610130-2	2011	Although the scope of PLP-catalyzed reactions initially appears to be bewilderingly diverse, there is a simple unifying principle: In the resting state, the cofactor (PLP) is covalently bonded to the amino group of an active site lysine, forming an internal aldimine.	Lysine	230-236	pyridoxal phosphatase	Homo sapiens	22-25
26610130-2	2011	Although the scope of PLP-catalyzed reactions initially appears to be bewilderingly diverse, there is a simple unifying principle: In the resting state, the cofactor (PLP) is covalently bonded to the amino group of an active site lysine, forming an internal aldimine.	Lysine	230-236	pyridoxal phosphatase	Homo sapiens	167-170
26610130-6	2011	The results indicate that the reaction involves three sequential steps: (i) formation of a tetrahedral intermediate with the active site lysine and the amino substrate bonded to the PLP cofactor; (ii) nondirect proton transfer between the amino substrate and the lysine residue; and (iii) formation of the external aldimine after the dissociation of the lysine residue.	Lysine	137-143	pyridoxal phosphatase	Homo sapiens	182-185
26610130-6	2011	The results indicate that the reaction involves three sequential steps: (i) formation of a tetrahedral intermediate with the active site lysine and the amino substrate bonded to the PLP cofactor; (ii) nondirect proton transfer between the amino substrate and the lysine residue; and (iii) formation of the external aldimine after the dissociation of the lysine residue.	Lysine	263-269	pyridoxal phosphatase	Homo sapiens	182-185
26610130-6	2011	The results indicate that the reaction involves three sequential steps: (i) formation of a tetrahedral intermediate with the active site lysine and the amino substrate bonded to the PLP cofactor; (ii) nondirect proton transfer between the amino substrate and the lysine residue; and (iii) formation of the external aldimine after the dissociation of the lysine residue.	Lysine	263-269	pyridoxal phosphatase	Homo sapiens	182-185
21396940-4	2011	UbcH5A is a promiscuous E2 enzyme with an innate preference for forming polyubiquitin chains through lysine 11 (K11), lysine 48 (K48), and lysine 63 (K63) of Ub.	Lysine	101-107	ubiquitin conjugating enzyme E2 D1	Homo sapiens	24-33
21396940-4	2011	UbcH5A is a promiscuous E2 enzyme with an innate preference for forming polyubiquitin chains through lysine 11 (K11), lysine 48 (K48), and lysine 63 (K63) of Ub.	Lysine	118-124	ubiquitin conjugating enzyme E2 D1	Homo sapiens	24-33
21396940-4	2011	UbcH5A is a promiscuous E2 enzyme with an innate preference for forming polyubiquitin chains through lysine 11 (K11), lysine 48 (K48), and lysine 63 (K63) of Ub.	Lysine	118-124	ubiquitin conjugating enzyme E2 D1	Homo sapiens	24-33
21322057-6	2011	The methylation of histone H3 at lysine 4 residue (H3K4me2) associated with the STAT (signal transducer and activator of transcription)-binding site of the GFAP promoter was significantly decreased in the gray matter of the FGF-2 null mouse, suggesting a role for FGF-2 in the epigenetic regulation of astrocyte differentiation in vivo.	Lysine	33-39	fibroblast growth factor 2	Mus musculus	224-229
21322057-6	2011	The methylation of histone H3 at lysine 4 residue (H3K4me2) associated with the STAT (signal transducer and activator of transcription)-binding site of the GFAP promoter was significantly decreased in the gray matter of the FGF-2 null mouse, suggesting a role for FGF-2 in the epigenetic regulation of astrocyte differentiation in vivo.	Lysine	33-39	fibroblast growth factor 2	Mus musculus	264-269
20688500-1	2011	Holocarboxylase synthetase (HCS) mediates the binding of biotin to lysine (K) residues in histones H2A, H3 and H4; HCS knockdown disturbs gene regulation and decreases stress resistance and lifespan in eukaryotes.	Lysine	67-73	holocarboxylase synthetase	Homo sapiens	0-26
20688500-1	2011	Holocarboxylase synthetase (HCS) mediates the binding of biotin to lysine (K) residues in histones H2A, H3 and H4; HCS knockdown disturbs gene regulation and decreases stress resistance and lifespan in eukaryotes.	Lysine	67-73	holocarboxylase synthetase	Homo sapiens	28-31
20688500-1	2011	Holocarboxylase synthetase (HCS) mediates the binding of biotin to lysine (K) residues in histones H2A, H3 and H4; HCS knockdown disturbs gene regulation and decreases stress resistance and lifespan in eukaryotes.	Lysine	67-73	holocarboxylase synthetase	Homo sapiens	115-118
21489093-0	2011	Expression analyses of AtAGP17 and AtAGP19, two lysine-rich arabinogalactan proteins, in Arabidopsis.	Lysine	48-54	arabinogalactan protein 19	Arabidopsis thaliana	35-42
21489093-4	2011	Peptide-specific antibodies were raised against the Lys-rich regions of AtAGP17 and AtAGP19 and used to study the organ-specific expression patterns of these two AGPs.	Lysine	52-55	arabinogalactan protein 19	Arabidopsis thaliana	84-91
21288202-7	2011	Co-mutating a second lysine residue (Lys903) located in the mGluR8b isoform-specific C-terminus largely prevented SUMO1 conjugation by Ubc9.	Lysine	21-27	small ubiquitin like modifier 1	Homo sapiens	114-119
21288202-7	2011	Co-mutating a second lysine residue (Lys903) located in the mGluR8b isoform-specific C-terminus largely prevented SUMO1 conjugation by Ubc9.	Lysine	21-27	ubiquitin conjugating enzyme E2 I	Homo sapiens	135-139
21447625-5	2011	The trimethylation of histone H3 at Lys 4 by the MLL2/MLL3 subunits of ASCOM, enhanced by the hormone-induced displacement of the H3K4 demethylase KDM5B, stabilizes NURF binding.	Lysine	36-39	lysine methyltransferase 2B	Homo sapiens	49-53
21447625-5	2011	The trimethylation of histone H3 at Lys 4 by the MLL2/MLL3 subunits of ASCOM, enhanced by the hormone-induced displacement of the H3K4 demethylase KDM5B, stabilizes NURF binding.	Lysine	36-39	lysine methyltransferase 2C	Homo sapiens	54-58
21447625-5	2011	The trimethylation of histone H3 at Lys 4 by the MLL2/MLL3 subunits of ASCOM, enhanced by the hormone-induced displacement of the H3K4 demethylase KDM5B, stabilizes NURF binding.	Lysine	36-39	lysine demethylase 5B	Homo sapiens	147-152
21428286-3	2011	For instance, it is unclear how L3MBTL1, a methyl-lysine histone code reader, recognizes equally well both mono- and dimethyl marks but ignores unmodified and trimethylated lysine residues.	Lysine	50-56	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	32-39
21490965-3	2011	In contrast to PDGF-A(S), the PDGF-A(L) isoform has a lysine and arginine rich carboxy-terminal extension that acts as an extracellular matrix retention motif.	Lysine	54-60	platelet derived growth factor, alpha	Mus musculus	30-36
25205925-1	2011	WNK1 (with no lysine (K)) is a widely expressed serine/threonine protein kinase.	Lysine	14-20	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
21244633-5	2011	In addition, mutated RGG containing Lys residues replacing Arg residues at specific Arg-Gly-Gly sites and RGG containing Arg methylated by protein arginine N-methyltransferase 3 decrease the binding ability of EWS to G-quadruplex DNA and RNA.	Lysine	36-39	EWS RNA binding protein 1	Homo sapiens	210-213
21296880-0	2011	Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence.	Lysine	75-81	D-2-hydroxyglutarate dehydrogenase	Homo sapiens	6-40
21245135-4	2011	During this initial process, SIRT1 deacetylated RelA/p65 lysine 310 and nucleosomal histone H4 lysine 16 to promote termination of NFkappaB-dependent transcription.	Lysine	57-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	48-52
21196496-1	2011	The Sotos syndrome gene product, NSD1, is a SET domain histone methyltransferase that primarily dimethylates nucleosomal histone H3 lysine 36 (H3K36).	Lysine	132-138	nuclear receptor binding SET domain protein 1	Homo sapiens	33-37
21488133-5	2011	The carbonyl assay using 2,4-dinitrophenylhydrazine revealed the possible involvement of Schiff"s base reaction between CDA and lysine.	Lysine	128-134	cytidine deaminase	Homo sapiens	120-123
21488133-6	2011	The adducts formed between beta-apo-8-carotenal (BA8C) and N-acetylcysteine and BA8C and N-acetyllysine were confirmed by HPLC and ESI-MS. Our results suggest that CDA could alter protein function by post-translational interaction with cysteine and lysine by thioether linkage and by schiff"s based bonds, respectively.	Lysine	97-103	cytidine deaminase	Homo sapiens	164-167
21157623-1	2011	The H4 histone tail plays a critical role in chromatin folding and regulation--it mediates strong interactions with the acidic patch of proximal nucleosomes and its acetylation at lysine 16 (K16) leads to partial unfolding of chromatin.	Lysine	180-186	keratin 16	Homo sapiens	191-194
21282610-0	2011	Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation.	Lysine	11-14	lysine methyltransferase 5A	Homo sapiens	55-59
21169561-3	2011	Pax3 acetylation on C-terminal lysine residues K437 and K475 may be critical for proper regulation of Hes1 and Neurog2.	Lysine	31-37	hes family bHLH transcription factor 1	Mus musculus	102-106
21169561-3	2011	Pax3 acetylation on C-terminal lysine residues K437 and K475 may be critical for proper regulation of Hes1 and Neurog2.	Lysine	31-37	neurogenin 2	Mus musculus	111-118
21169561-4	2011	Removal of these lysine residues increased Hes1 but decreased Neurog2 promoter activity.	Lysine	17-23	hes family bHLH transcription factor 1	Mus musculus	43-47
21169561-4	2011	Removal of these lysine residues increased Hes1 but decreased Neurog2 promoter activity.	Lysine	17-23	neurogenin 2	Mus musculus	62-69
21127046-6	2011	Furthermore, we show that the initiating form of RNA polymerase II and histone H3 trimethylated on lysine 4, a chromatin mark tightly linked to transcription initiation, are both present at lower levels on FRDA alleles.	Lysine	99-105	frataxin	Homo sapiens	206-210
21157427-3	2011	In this study, we provide the first evidence that the acetyltransferase Tip60 acetylates SRSF2 on its lysine 52 residue inside the RNA recognition motif, and promotes its proteasomal degradation.	Lysine	102-108	serine and arginine rich splicing factor 2	Homo sapiens	89-94
21157427-7	2011	Taken together, these results unravel lysine acetylation as a crucial post-translational modification regulating SRSF2 protein level and activity in response to genotoxic stress.	Lysine	38-44	serine and arginine rich splicing factor 2	Homo sapiens	113-118
21416054-1	2011	KLF8 regulates target genes by recruiting the p300 and PCAF co-activators via glutamines (Q) 118 and 248, the CtBP co-repressor to 86PVDLS90 or SUMO to lysine (K) 67.	Lysine	152-158	Kruppel like factor 8	Homo sapiens	0-4
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Lysine	161-167	E1A binding protein p300	Homo sapiens	59-63
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Lysine	161-167	lysine acetyltransferase 2B	Homo sapiens	71-75
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Lysine	161-167	Kruppel like factor 8	Homo sapiens	85-89
21115810-3	2011	We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes.	Lysine	136-139	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	14-19
21115810-3	2011	We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes.	Lysine	136-139	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	147-152
21148752-9	2011	We confirmed that Merm1 suppressed Zac1 expression with histone H3 methylation at Lys(9) in the Zac1 promoter region.	Lysine	82-85	pleiomorphic adenoma gene-like 1	Mus musculus	35-39
21148752-9	2011	We confirmed that Merm1 suppressed Zac1 expression with histone H3 methylation at Lys(9) in the Zac1 promoter region.	Lysine	82-85	pleiomorphic adenoma gene-like 1	Mus musculus	96-100
21265892-3	2011	We show that the quantitative induction of the first gene in the Arabidopsis vernalization pathway, VERNALIZATION INSENSITIVE 3 (VIN3), is regulated by the components of Polycomb Response Complex 2, which trimethylates histone H3 lysine 27 (H3K27me3).	Lysine	230-236	Fibronectin type III domain-containing protein	Arabidopsis thaliana	100-127
21265892-3	2011	We show that the quantitative induction of the first gene in the Arabidopsis vernalization pathway, VERNALIZATION INSENSITIVE 3 (VIN3), is regulated by the components of Polycomb Response Complex 2, which trimethylates histone H3 lysine 27 (H3K27me3).	Lysine	230-236	Fibronectin type III domain-containing protein	Arabidopsis thaliana	129-133
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 19	Homo sapiens	32-35
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 19	Homo sapiens	134-137
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 19	Homo sapiens	32-35
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 19	Homo sapiens	32-35
21149657-1	2011	PURPOSE: A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel vaccination with alpha-type 1 polarized dendritic cells (alphaDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in HLA-A2(+) patients with recurrent malignant gliomas.	Lysine	318-324	alpha glucosidase	Homo sapiens	197-228
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	25-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	25-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	115-121
21071436-8	2011	Remarkably, the attached Lys-48- and Lys-63-linked ubiquitin chains are homogeneous and are segregated to separate IP(3)R subunits, and Lys-48-linked ubiquitin chains, but not Lys-63-linked chains, are required for IP(3)R degradation.	Lysine	37-40	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	215-221
21332356-2	2011	Titin is responsible for the passive elasticity in muscle and is a chain composed of immunoglobulin (Ig)-like and fibronectin III (FN-III)-like domains, as well as PEVK segments rich in proline (P), glutamate (E), valine (V), and lysine (K).	Lysine	230-236	titin	Homo sapiens	0-5
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Lysine	218-224	prion like protein doppel	Homo sapiens	25-28
24342356-5	2014	Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIalpha down-regulation of cyclin D1 protein expression and that MEK1/2-Erk was a specific downstream target of SUMOylated RhoGDIalpha for its inhibition of C-Jun/AP-1 cascade, cyclin d1 transcription, and cell cycle progression.	Lysine	43-46	cyclin D1	Homo sapiens	99-108
24415758-0	2014	Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.	Lysine	0-6	progesterone receptor	Homo sapiens	22-43
24415758-5	2014	Mutational analysis revealed the remarkable importance of Lys-464 in regulating PR activity.	Lysine	58-61	progesterone receptor	Homo sapiens	80-82
24415758-8	2014	In contrast, mutation of Lys-464 to the bulkier phenylalanine to mimic the effect of methylation caused a drastic decrease in PR activity.	Lysine	25-28	progesterone receptor	Homo sapiens	126-128
24415758-10	2014	These results suggest that monomethylation of PR at Lys-464 probably has a repressive effect on AF-1 activity and ligand sensitivity.	Lysine	52-55	progesterone receptor	Homo sapiens	46-48
24443569-0	2014	The different inhibition mechanisms of OXA-1 and OXA-24 beta-lactamases are determined by the stability of active site carboxylated lysine.	Lysine	132-138	OXA1L mitochondrial inner membrane protein	Homo sapiens	39-44
24581496-6	2014	This involves acetylation of HSF1 at multiple lysines not required for function and results in stabilization of HSF1 against proteasomal turnover.	Lysine	46-53	heat shock transcription factor 1	Homo sapiens	29-33
24581496-6	2014	This involves acetylation of HSF1 at multiple lysines not required for function and results in stabilization of HSF1 against proteasomal turnover.	Lysine	46-53	heat shock transcription factor 1	Homo sapiens	112-116
24581496-7	2014	Acetylation of functionally critical lysines during stress serves to fine-tune HSF1 activation.	Lysine	37-44	heat shock transcription factor 1	Homo sapiens	79-83
24403071-3	2014	Here we report that Otub1 is monoubiquitinated by UbcH5 in cells and in vitro, primarily at the lysine 59 and 109 residues.	Lysine	96-102	ubiquitin conjugating enzyme E2 D1	Homo sapiens	50-55
21054678-3	2011	As the interaction was mediated by the SUV39H1 SET domain that is shared among HMTases, we examined the possibility of Tax interaction with another HMTase, SMYD3, which methylates histone H3 lysine 4 and activates transcription of genes, and studied the functional effects.	Lysine	191-197	SET and MYND domain containing 3	Homo sapiens	156-161
26994210-5	2016	A SPOT peptide array approach and NMR titration experiments confirmed binding of Abeta(1-40) to the catalytic site of CypD mainly via residues Lys(16)-Glu(22) The peptide Abeta(16-20) representing this section showed submicromolar IC50 values for the peptidyl prolyl cis-trans isomerase activity of CypD and CypA and low-micromolar KD values in ITC experiments.	Lysine	143-146	peptidylprolyl isomerase D	Homo sapiens	118-122
22140534-0	2011	Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression.	Lysine	28-34	ASH1 like histone lysine methyltransferase	Homo sapiens	56-60
26965372-7	2016	Furthermore, Ssdp1/2 recruit histone-modifying enzymes to the motor neuron-specifying LIM complex and trigger acetylation and lysine 4 trimethylation of histone H3, which are well-established chromatin marks for active transcription.	Lysine	126-132	PDZ and LIM domain 5	Mus musculus	86-89
21829453-6	2011	The detected patterns are a well-studied acetylation of lysine 16 of H4 in glucose depletion as well as co-acetylation of five lysine residues of H3 with H4 Lys12 and H2A Lys7 responsible for ribosome biogenesis.	Lysine	127-133	copper chaperone CCS1	Saccharomyces cerevisiae S288C	171-175
24495580-3	2014	RESULTS: Here, we show that KDM5B, which demethylates lysine 4 of histone H3, co-localizes with H3K4me3 near promoters and enhancers of active genes in ES cells; its depletion leads to spreading of H3K4 methylation into gene bodies and enhancer shores, indicating that KDM5B functions to focus H3K4 methylation at promoters and enhancers.	Lysine	54-60	lysine demethylase 5B	Homo sapiens	28-33
21677783-3	2011	Sumoylation enhanced Nkx2.5 activity via covalent attachment to the lysine residue 51, the primary SUMO acceptor site.	Lysine	68-74	NK2 homeobox 5	Mus musculus	21-27
24298021-5	2014	In this report, we demonstrate that Gcn5p acetylation of separate lysines within the zinc cluster domain negatively impacts Ume6p DNA binding.	Lysine	66-73	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	124-129
27166806-4	2016	Research of the MARCKS-ED has further revealed that its Lys and Phe residues play an essential role in how MARCKS-ED detects and binds to curved bilayers.	Lysine	56-59	myristoylated alanine rich protein kinase C substrate	Homo sapiens	16-22
24298021-6	2014	Mimicking lysine acetylation using glutamine substitution mutations decreased Ume6p binding efficiency and resulted in partial derepression of Ume6p-regulated genes.	Lysine	10-16	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	78-83
24298021-6	2014	Mimicking lysine acetylation using glutamine substitution mutations decreased Ume6p binding efficiency and resulted in partial derepression of Ume6p-regulated genes.	Lysine	10-16	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	143-148
24298021-7	2014	Consistent with this result, molecular modeling predicted that these lysine side chains are adjacent to the DNA phosphate backbone, suggesting that acetylation inhibits Ume6p binding by electrostatic repulsion.	Lysine	69-75	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	169-174
20956533-3	2010	DHS catalyzes the conversion of lysine to hypusine, an amino acid that is unique to the translational elongation factor eIF5A.	Lysine	32-38	eukaryotic translation initiation factor 5A	Mus musculus	120-125
27166806-4	2016	Research of the MARCKS-ED has further revealed that its Lys and Phe residues play an essential role in how MARCKS-ED detects and binds to curved bilayers.	Lysine	56-59	myristoylated alanine rich protein kinase C substrate	Homo sapiens	107-113
26915459-5	2016	Upon viral infection, TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.	Lysine	39-42	glycogen synthase kinase 3 beta	Homo sapiens	112-120
20855868-5	2010	The cluster is characterized by elevated levels of histone 3 lysine 4 mono-methylation, a chromatin signature of enhancers, and efficiently binds RelA-containing NF-kappaB complexes in vitro and in vivo.	Lysine	61-67	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-150
24274971-12	2014	These results showed that site-specific Lys(30)-PEG-GLP-2 was resistant to degradation and reduced the severity of colonic injury in murine colitis.	Lysine	40-43	glucagon-like peptide 2 receptor	Mus musculus	52-57
24302725-5	2014	Furthermore, p300-mediated Lys-183 acetylation is associated with heightened PR activity.	Lysine	27-30	progesterone receptor	Homo sapiens	77-79
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	MLLT6, PHD finger containing	Homo sapiens	160-164
26915459-5	2016	Upon viral infection, TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.	Lysine	39-42	interferon regulatory factor 3	Homo sapiens	159-163
24302725-8	2014	Additionally, increases of Lys-183 acetylation by p300 overexpression or inhibition of deacetylation resulted in increases of Ser-294 phosphorylation levels.	Lysine	27-30	E1A binding protein p300	Homo sapiens	50-54
24302725-9	2014	In conclusion, PR acetylation at Lys-183 by p300 potentiates PR activity through accelerated binding of its direct target genes without affecting PR tethering on other transcription factors.	Lysine	33-36	progesterone receptor	Homo sapiens	15-17
24302725-9	2014	In conclusion, PR acetylation at Lys-183 by p300 potentiates PR activity through accelerated binding of its direct target genes without affecting PR tethering on other transcription factors.	Lysine	33-36	E1A binding protein p300	Homo sapiens	44-48
24302725-9	2014	In conclusion, PR acetylation at Lys-183 by p300 potentiates PR activity through accelerated binding of its direct target genes without affecting PR tethering on other transcription factors.	Lysine	33-36	progesterone receptor	Homo sapiens	61-63
21156283-3	2010	Inhibition of JAK2 and JMJD2C cooperated in killing these lymphomas by decreasing tyrosine 41 phosphorylation and increasing lysine 9 trimethylation of histone H3, promoting heterochromatin formation.	Lysine	125-131	Janus kinase 2	Homo sapiens	14-18
24302725-9	2014	In conclusion, PR acetylation at Lys-183 by p300 potentiates PR activity through accelerated binding of its direct target genes without affecting PR tethering on other transcription factors.	Lysine	33-36	progesterone receptor	Homo sapiens	61-63
26940890-1	2016	NSD1 is a SET-domain histone methyltransferase that methylates lysine 36 of histone 3.	Lysine	63-69	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
24475074-8	2014	Given the topology of the genetic code, mutation of (A) is more often nonsynonomous, and Lys, another target of many PTMs, is also encoded by two (A)-rich codons.	Lysine	89-92	parathymosin	Homo sapiens	117-121
21167755-3	2010	RAUL limited type I IFN production by directly catalyzing lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed by proteasome-dependent degradation.	Lysine	58-64	interferon regulatory factor 3	Homo sapiens	144-148
21110373-6	2010	The shorter R groups of the Dap and Dab groups appear to have a better length than lysine for enhancement of the thermal melting of the 2"-O-methylRNA/RNA duplex, an effect that is more pronounced at lower pH but substantial even at pH 7, although the Dap derivative is not likely to be fully protonated.	Lysine	83-89	death associated protein	Homo sapiens	28-31
21110373-6	2010	The shorter R groups of the Dap and Dab groups appear to have a better length than lysine for enhancement of the thermal melting of the 2"-O-methylRNA/RNA duplex, an effect that is more pronounced at lower pH but substantial even at pH 7, although the Dap derivative is not likely to be fully protonated.	Lysine	83-89	death associated protein	Homo sapiens	252-255
26940890-2	2016	In the crystal structure of NSD1, the post-SET loop is in an autoinhibitory position that blocks binding of the histone peptide as well as the entrance to the lysine-binding channel.	Lysine	159-165	nuclear receptor binding SET domain protein 1	Homo sapiens	28-32
20813101-6	2010	The ALDH2 *2 allele encodes a protein with an amino acid change from glutamate to lysine (derived from the ALDH2*1 allele) and devoid of enzymatic activity.	Lysine	82-88	aldehyde dehydrogenase 2 family member	Homo sapiens	4-9
20813101-6	2010	The ALDH2 *2 allele encodes a protein with an amino acid change from glutamate to lysine (derived from the ALDH2*1 allele) and devoid of enzymatic activity.	Lysine	82-88	aldehyde dehydrogenase 2 family member	Homo sapiens	107-112
26929412-6	2016	By contrast, SMYD3 displayed a weak activity toward a VEGFR1 peptide, and the location of the acceptor lysine in the folded kinase domain of VEGFR1 requires drastic conformational rearrangements for juxtaposition of the acceptor lysine with the enzymatic active site.	Lysine	103-109	SET and MYND domain containing 3	Homo sapiens	13-18
21067189-7	2010	In the context of N-terminal transamination, a highly reactive alanine-lysine motif emerged, which was confirmed to promote the modification of peptide substrates with PLP.	Lysine	71-77	pyridoxal phosphatase	Homo sapiens	168-171
24462205-4	2014	Here, we show that asymmetric SUMOylation of a conserved lysine residue in the N domain of both yeast (K178) and human (K191) Hsp90 facilitates both recruitment of the adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90 inhibitors, suggesting that these drugs associate preferentially with Hsp90 proteins that are actively engaged in the chaperone cycle.	Lysine	57-63	activator of HSP90 ATPase activity 1	Homo sapiens	225-229
26929412-6	2016	By contrast, SMYD3 displayed a weak activity toward a VEGFR1 peptide, and the location of the acceptor lysine in the folded kinase domain of VEGFR1 requires drastic conformational rearrangements for juxtaposition of the acceptor lysine with the enzymatic active site.	Lysine	229-235	SET and MYND domain containing 3	Homo sapiens	13-18
24409311-6	2014	Transcriptional up- and down-regulation accompany an increase in acetylation levels of histone H3 lysine 9 at the promoter regions of Abcb1b and Abcb1a, respectively.	Lysine	98-104	ATP binding cassette subfamily B member 1A	Rattus norvegicus	145-151
26929412-7	2016	Our results clearly revealed structural determinants for the substrate preference of SMYD3 and provided mechanistic insights into lysine methylation of MAP3K2.	Lysine	130-136	SET and MYND domain containing 3	Homo sapiens	85-90
27051063-2	2016	One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5).	Lysine	16-22	sirtuin 5	Mus musculus	60-69
24761888-6	2014	Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively.	Lysine	108-111	aryl hydrocarbon receptor	Homo sapiens	120-123
24096733-5	2014	Using Ubc9 (SUMO-conjugating enzyme) fusion and mutation analysis, we identified evolutionarily conserved lysine 329 as the major SUMOylation site of TAB2.	Lysine	106-112	ubiquitin conjugating enzyme E2 I	Homo sapiens	6-10
21221920-5	2010	ChIP experiments demonstrate that HTRP could promote HDAC activity by increasing the deacetylation level of lysine 14 and lysine 9 in histone H3.	Lysine	108-114	SAP30 binding protein	Homo sapiens	34-38
21221920-5	2010	ChIP experiments demonstrate that HTRP could promote HDAC activity by increasing the deacetylation level of lysine 14 and lysine 9 in histone H3.	Lysine	122-128	SAP30 binding protein	Homo sapiens	34-38
21151776-5	2010	Mutational analysis showed that NSP4 viroporin activity was mediated by an amphipathic alpha-helical domain downstream of a conserved lysine cluster.	Lysine	134-140	serine protease 57	Homo sapiens	32-36
27051063-2	2016	One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5).	Lysine	16-22	sirtuin 5	Mus musculus	71-76
26972250-1	2016	The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues.	Lysine	127-133	delta/notch like EGF repeat containing	Homo sapiens	35-38
21074459-4	2010	TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination.	Lysine	49-55	stimulator of interferon response cGAMP interactor 1	Homo sapiens	23-28
24518117-3	2014	We define a region on the RING domain important for target recognition and identify the H2A/H2B dimer as the minimal substrate to confer lysine specificity to the RNF168 reaction.	Lysine	137-143	ring finger protein 168	Homo sapiens	163-169
24309976-1	2014	We present a protocol for using the triple malignant brain tumor domains of L3MBTL1 (3xMBT), which bind to mono- and di-methylated lysine with minimal sequence specificity, in order to enrich for such methylated lysine from cell lysates.	Lysine	131-137	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	76-83
27007701-3	2016	Molecular dynamics simulations showed that the lysine side chain of the polymers physically occludes the pore of Kv1.3, a target for immuno-suppression therapy.	Lysine	47-53	potassium voltage-gated channel subfamily A member 3	Homo sapiens	113-118
24309976-1	2014	We present a protocol for using the triple malignant brain tumor domains of L3MBTL1 (3xMBT), which bind to mono- and di-methylated lysine with minimal sequence specificity, in order to enrich for such methylated lysine from cell lysates.	Lysine	212-218	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	76-83
24391744-3	2013	Using binding assays and X-ray crystallography, we now show that RVX-208 selectively binds to bromodomains of the BET (Bromodomain and Extra Terminal) family, competing for a site bound by the endogenous ligand, acetylated lysine, and that this accounts for its pharmacological activity.	Lysine	223-229	delta/notch like EGF repeat containing	Homo sapiens	114-117
20936831-1	2010	Cytochrome c (cyt c) derivatives modified with a platinum(II) complex at the lysine residue, cyt c(III)-[Pt(bpy)(dapap)](1) {bpy = 2,2"-bipyridine, and dapap = 3-(2,3-diaminopropionylamino)propionic acid}, have been prepared.	Lysine	77-83	LOC104968582	Bos taurus	0-12
27008626-2	2016	Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family (Brd2, Brd3, Brd4, Brdt), making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes.	Lysine	84-91	delta/notch like EGF repeat containing	Homo sapiens	15-18
21061498-10	2004	(111)In-Diethylenetriamine pentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 ((111)In-DTPA-Ahx-Lys(40)-exendin-4) has been developed for single-photon emission computed tomography (SPECT) imaging of the GLP-1R (5, 6).	Lysine	63-66	glucagon like peptide 1 receptor	Homo sapiens	207-213
21061499-10	2004	(111)In-Diethylenetriamine pentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 ((111)In-DTPA-Ahx-Lys(40)-exendin-4) has been developed for single-photon emission computed tomography (SPECT) imaging of the GLP-1R (5, 6).	Lysine	63-66	glucagon like peptide 1 receptor	Homo sapiens	207-213
27008626-2	2016	Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family (Brd2, Brd3, Brd4, Brdt), making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes.	Lysine	84-91	delta/notch like EGF repeat containing	Homo sapiens	50-53
20461737-1	2010	White lupin is considered to be a rich source of protein with a notable content of lysine and is being increasingly used in bakery, confectionery, snacks and pastry products due to its multifunctional properties, in addition to its potential hypocholesterolemic and hypoglycemic properties.	Lysine	83-89	5'-nucleotidase, cytosolic IIIA	Homo sapiens	6-11
27008626-2	2016	Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family (Brd2, Brd3, Brd4, Brdt), making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes.	Lysine	84-91	delta/notch like EGF repeat containing	Homo sapiens	50-53
26755727-5	2016	Surprisingly, recent reports claim that Naa10 may also acetylate lysine residues of diverse targets, including methionine sulfoxide reductase A, myosin light chain kinase, and Runt-related transcription factor 2.	Lysine	65-71	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	40-45
20817754-5	2010	Continuous expression of the short ncRNA maintains a high level of trimethylation of histone H3 at lysine 4 (H3K4me3) at the ASP3 promoter and makes this region more accessible for RNAPII to transcribe the full-length ASP3.	Lysine	99-105	asparaginase ASP3-1	Saccharomyces cerevisiae S288C	125-129
20863814-1	2010	JARID1B/KDM5B (jumonji AT-rich interactive domain 1B/lysine-specific demethylase 5B) is an enzyme that efficiently removes methyl residues from trimethylated lysine 4 on histone H3, a pivotal mark for active chromatin.	Lysine	53-59	lysine demethylase 5B	Homo sapiens	0-7
20863814-1	2010	JARID1B/KDM5B (jumonji AT-rich interactive domain 1B/lysine-specific demethylase 5B) is an enzyme that efficiently removes methyl residues from trimethylated lysine 4 on histone H3, a pivotal mark for active chromatin.	Lysine	53-59	lysine demethylase 5B	Homo sapiens	8-13
24217247-8	2013	Targeted point mutations recognized that amino acids Lys-233, Glu-236, and Lys-240 in helix 10 mediate the interaction of AKR1B10 with HSP90alpha.	Lysine	53-56	aldo-keto reductase family 1 member B10	Homo sapiens	122-129
24217247-8	2013	Targeted point mutations recognized that amino acids Lys-233, Glu-236, and Lys-240 in helix 10 mediate the interaction of AKR1B10 with HSP90alpha.	Lysine	75-78	aldo-keto reductase family 1 member B10	Homo sapiens	122-129
24490124-1	2013	We report here the design and synthesis of an ABC miktoarm star peptide connecting through a lysine junction a short peptide sequence and two hydrophobic but immiscible blocks (a hydrocarbon and a fluorocarbon).	Lysine	93-99	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	46-49
20863814-1	2010	JARID1B/KDM5B (jumonji AT-rich interactive domain 1B/lysine-specific demethylase 5B) is an enzyme that efficiently removes methyl residues from trimethylated lysine 4 on histone H3, a pivotal mark for active chromatin.	Lysine	53-59	lysine demethylase 5B	Homo sapiens	15-52
20863814-9	2010	In conclusion, JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells.	Lysine	139-145	lysine demethylase 5B	Homo sapiens	15-22
26755727-6	2016	Here we used recombinant proteins to reconstitute and assess lysine acetylation events catalyzed by Naa10 in vitro.	Lysine	61-67	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	100-105
20705923-0	2010	Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.	Lysine	118-124	histone deacetylase 3	Homo sapiens	0-21
26942676-3	2016	Here we show that TRIM21 plays an essential role in redox regulation by directly interacting with SQSTM1/p62 and ubiquitylating p62 at lysine 7 (K7) via K63-linkage.	Lysine	135-141	tripartite motif-containing 21	Mus musculus	18-24
20810994-8	2010	The inhibitory effect of ISG15 or ISGylation on NS5A was efficiently blocked by substitution of lysine at 379 residue to arginine within the C-terminal region, suggesting that ISGylation directly controls protein stability of NS5A.	Lysine	96-102	ISG15 ubiquitin like modifier	Homo sapiens	25-30
24189064-4	2013	Here we report that Tax induced the acetylation of lysine 310 of RelA and the binding of Brd4 to acetylated RelA to facilitate Tax-mediated transcriptional activation of NF-kappaB.	Lysine	51-57	RELA proto-oncogene, NF-kB subunit	Homo sapiens	65-69
24189064-4	2013	Here we report that Tax induced the acetylation of lysine 310 of RelA and the binding of Brd4 to acetylated RelA to facilitate Tax-mediated transcriptional activation of NF-kappaB.	Lysine	51-57	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-112
24189068-1	2013	Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and survival.	Lysine	34-40	protein arginine N-methyltransferase 5	Mus musculus	188-193
26942676-3	2016	Here we show that TRIM21 plays an essential role in redox regulation by directly interacting with SQSTM1/p62 and ubiquitylating p62 at lysine 7 (K7) via K63-linkage.	Lysine	135-141	sequestosome 1	Mus musculus	128-131
20672293-9	2010	ChIP assay revealed decreased trimethylation of lysine 4 in histone 3 (H3K4) in the TARC promoter region of BEAS-2B cells.	Lysine	48-54	C-C motif chemokine ligand 17	Homo sapiens	84-88
26850942-7	2016	Moreover, Ang II induced ATF3 SUMOylation at lysine 42, which is SUMO1 dependent.	Lysine	45-51	activating transcription factor 3	Mus musculus	25-29
20837538-0	2010	Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.	Lysine	100-106	nuclear receptor binding SET domain protein 1	Homo sapiens	13-58
20837538-0	2010	Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.	Lysine	100-106	nuclear receptor binding SET domain protein 1	Homo sapiens	60-64
24200290-4	2013	The results indicate that there are particular lysine residues whose environment changes in the presence of dithiothreitol or eIF4G, suggesting that changes in the structure of eIF4E are occurring.	Lysine	47-53	eukaryotic translation initiation factor 4E-1	Triticum aestivum	177-182
24200290-5	2013	On the basis of the crystal structure of wheat eIF4E and a constructed homology model of the structure for eIFiso4E, the reactivities of lysines in each protein are rationalized.	Lysine	137-144	eukaryotic translation initiation factor 4E-1	Triticum aestivum	47-52
24147985-0	2013	NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5"-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine.	Lysine	163-176	pyridoxal phosphatase	Homo sapiens	77-99
20837538-3	2010	Previous studies have implicated NSD1 (KMT3B) in transcription and methylation of histone H3 at lysine 36 (H3-K36), but its molecular mechanism in these processes remains largely unknown.	Lysine	96-102	nuclear receptor binding SET domain protein 1	Homo sapiens	33-37
27011246-2	2016	FHHt results from mutations in the genes encoding WNK1 and WNK4, two serine-threonine kinases of the WNK (With No lysine [K]) family.	Lysine	114-120	WNK lysine deficient protein kinase 1	Homo sapiens	50-54
20728365-0	2010	Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide.	Lysine	19-22	pro-opiomelanocortin-alpha	Mus musculus	153-189
20728365-1	2010	The purpose of this study was to reduce the non-specific renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide through structural modification or L-lysine co-injection.	Lysine	201-209	pro-opiomelanocortin-alpha	Mus musculus	102-138
20728365-1	2010	The purpose of this study was to reduce the non-specific renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide through structural modification or L-lysine co-injection.	Lysine	201-209	pro-opiomelanocortin-alpha	Mus musculus	140-149
24147985-1	2013	Using (15)N solid-state NMR, we have studied protonation and H-bonded states of the cofactor pyridoxal 5"-phosphate (PLP) linked as an internal aldimine in alanine racemase (AlaR), aspartate aminotransferase (AspAT), and poly-L-lysine.	Lysine	221-234	pyridoxal phosphatase	Homo sapiens	93-115
26631572-4	2016	In xenograft tumors generated by injection of wild-type mice with lung adenocarcinoma cells alone or in combination with CAFs, the total concentration of collagen cross-links was the same in tumors generated with or without CAFs, but coinjected tumors had higher hydroxylysine aldehyde-derived collagen cross-links (HLCC) and lower lysine-aldehyde-derived collagen cross-links (LCCs).	Lysine	270-276	T-box transcription factor 1	Homo sapiens	121-125
26816087-2	2016	Jumonji domain-containing histone-lysine demethylases (Jmj-KDMs) remove the methyl moiety from lysine residues in histones by utilizing Fe(2+) and alpha-ketoglutarate.	Lysine	34-40	jumonji and AT-rich interaction domain containing 2	Homo sapiens	55-58
24183574-2	2013	Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/beta-catenin.	Lysine	53-59	legless	Drosophila melanogaster	94-101
24183574-2	2013	Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/beta-catenin.	Lysine	53-59	legless	Drosophila melanogaster	102-106
24183574-2	2013	Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/beta-catenin.	Lysine	53-59	pygopus	Drosophila melanogaster	126-130
24183574-2	2013	Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/beta-catenin.	Lysine	53-59	armadillo	Drosophila melanogaster	134-156
20805500-0	2010	Ubiquitination of lysine-331 by Kaposi"s sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradation.	Lysine	18-24	homeostatic iron regulator	Homo sapiens	91-94
20840750-7	2010	Moreover, using oligonucleotide-based degenerate PCR, we discovered that mutation of Arg-501 and Lys-503 of mCRY2 within this C-terminal region totally abolishes interaction with PER2.	Lysine	97-100	cryptochrome 2 (photolyase-like)	Mus musculus	108-113
26911690-6	2016	To elucidate the molecular mechanism of these alterations in the endocytic pathway in Parkin-deficient cells, we found that Parkin regulates the levels and activity of Rab7 by promoting its ubiquitination on lysine 38 residue.	Lysine	208-214	RAB7B, member RAS oncogene family	Homo sapiens	168-172
20838441-0	2010	Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.	Lysine	86-92	ornithine decarboxylase 1	Homo sapiens	0-23
20838441-5	2010	Ectopic expression of OAZ mediated hypomethylation of CpG islands of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2).	Lysine	95-101	ornithine decarboxylase antizyme 1	Homo sapiens	22-25
24115035-8	2013	Moreover, the augmented association of p52/acetylation of histone H3 at lysine 56 with the promoter of ubiquitin E3 ligase, S-phase kinase-associated protein 2, was shown in AMPKalpha2(-/-) VSMCs by chromatin immunoprecipitation assay.	Lysine	72-78	S-phase kinase-associated protein 2	Mus musculus	124-159
26915321-5	2016	Acetylation of NF-kappaB p65 at lysine 221 site was assessed by Western blot.	Lysine	32-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	25-28
23962003-4	2013	Random modification of lysine residues in IFN-beta with amine-reactive PEGs decreased the in vitro bioactivity of the protein 50-fold, presumably due to modification of lysine residues near critical receptor binding sites.	Lysine	23-29	interferon beta 1	Homo sapiens	42-50
23962003-4	2013	Random modification of lysine residues in IFN-beta with amine-reactive PEGs decreased the in vitro bioactivity of the protein 50-fold, presumably due to modification of lysine residues near critical receptor binding sites.	Lysine	169-175	interferon beta 1	Homo sapiens	42-50
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	66-72	X-ray repair cross complementing 4	Homo sapiens	57-62
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	matrix metallopeptidase 9	Mus musculus	257-283
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	matrix metallopeptidase 9	Mus musculus	285-290
20674369-5	2010	The pentagalactosylated dendrimer J4 betaGal(4)(Lys-Arg-His-Leu)(2)Dap-Thr-Tyr-His-Lys(betaGal)-Cys) selectively labels Jurkat cell as the fluorescein derivative J4F, but its colchicine conjugate J4C lacks cytotoxicity.	Lysine	48-51	death associated protein	Homo sapiens	67-70
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	81-87	X-ray repair cross complementing 4	Homo sapiens	57-62
24191046-2	2013	A central constriction of six apolar residues has been shown to form a seal, but also to determine the hydrophobicity threshold for membrane integration: Mutation of these residues in yeast Sec61p to glycines, serines, aspartates, or lysines lowered the hydrophobicity required for integration; mutation to alanines increased it.	Lysine	234-241	translocon subunit SEC61	Saccharomyces cerevisiae S288C	190-196
20577673-3	2010	The lysine methyltransferase G9a and its interaction partner Glp1 can mono- or dimethylate histone H3 on lysine (H3K9me1 or me2); possible cross-talk between these modifications and other PTMs on the same or other histone molecules is currently uncharacterized.	Lysine	4-10	glucagon like peptide 1 receptor	Homo sapiens	61-65
26784169-5	2016	Both complexes can acetylate histone H4 at lysine 16 (H4K16); however, the NSL complex possesses broader substrate specificity and can also acetylate histone H4 at lysines 5 and 8 (H4K5 and H4K8), suggesting the complexity of the intracellular functions of MOF.	Lysine	164-171	lysine acetyltransferase 8	Homo sapiens	257-260
20592038-5	2010	Stopped-flow and steady-state experiments revealed that individual charges at Lys(423), Lys(620), and Lys(660) were the most important in enabling heme reduction in nNOS.	Lysine	78-81	nitric oxide synthase 1	Homo sapiens	165-169
20592038-5	2010	Stopped-flow and steady-state experiments revealed that individual charges at Lys(423), Lys(620), and Lys(660) were the most important in enabling heme reduction in nNOS.	Lysine	88-91	nitric oxide synthase 1	Homo sapiens	165-169
20592038-5	2010	Stopped-flow and steady-state experiments revealed that individual charges at Lys(423), Lys(620), and Lys(660) were the most important in enabling heme reduction in nNOS.	Lysine	88-91	nitric oxide synthase 1	Homo sapiens	165-169
20592038-9	2010	We conclude that heme reduction and NO synthesis in nNOS is enabled by electrostatic interactions involving Lys(423), Lys(620), and Lys(660), which form a triad of positive charges on the NOSoxy surface.	Lysine	108-111	nitric oxide synthase 1	Homo sapiens	52-56
20592038-9	2010	We conclude that heme reduction and NO synthesis in nNOS is enabled by electrostatic interactions involving Lys(423), Lys(620), and Lys(660), which form a triad of positive charges on the NOSoxy surface.	Lysine	118-121	nitric oxide synthase 1	Homo sapiens	52-56
24207025-3	2013	Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the largest polymerase subunit and is mediated by p300/KAT3B.	Lysine	28-35	E1A binding protein p300	Homo sapiens	124-128
20592038-9	2010	We conclude that heme reduction and NO synthesis in nNOS is enabled by electrostatic interactions involving Lys(423), Lys(620), and Lys(660), which form a triad of positive charges on the NOSoxy surface.	Lysine	118-121	nitric oxide synthase 1	Homo sapiens	52-56
24207025-3	2013	Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the largest polymerase subunit and is mediated by p300/KAT3B.	Lysine	28-35	E1A binding protein p300	Homo sapiens	129-134
26586842-8	2016	The key targets of PRDM1 in migrating and/or gonadal PGCs, including genes for development, apoptosis, and prospermatogonial differentiation, showed only a modest overlap with those upon PGC specification, and were enriched with histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	240-246	PR domain containing 1, with ZNF domain	Mus musculus	19-24
20483643-5	2010	Analysis of bimolecular complexes of Venezuelan equine encephalitis virus (VEEV) nsP2 protease with each of the nsP1234 cleavage sites identified protease residues His(510), Ser(511), His(546) and Lys(706) as critical for cleavage site recognition.	Lysine	197-200	reticulon 2	Homo sapiens	81-85
26077029-6	2016	Amino acid analysis post the exposure of hCP to SAL revealed that aspartate, histidine, lysine, threonine and tyrosine residues were particularly sensitive.	Lysine	88-94	coproporphyrinogen oxidase	Homo sapiens	41-44
20617841-1	2010	Human plasminogen kringle 3 (hPgn K3) domain contains most elements of the canonical lysine-binding site (LBS) found in other Pgn kringles.	Lysine	85-91	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	30-33
23970103-1	2013	The histone lysine demethylase KDM5B plays key roles in gene repression by demethylating trimethylated lysine 4 of histone H3 (H3K4me3), a modification commonly found at the promoter region of actively transcribed genes.	Lysine	12-18	lysine demethylase 5B	Homo sapiens	31-36
23970103-3	2013	Herein, we report that KDM5B is SUMOylated at lysine residues 242 and 278 and that the ectopic expression of the hPC2 SUMO E3 ligase enhances this SUMOylation.	Lysine	46-52	lysine demethylase 5B	Homo sapiens	23-28
25761473-1	2016	PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA.	Lysine	92-98	chromobox 3	Homo sapiens	9-39
24052262-6	2013	These lysines lie within previously predicted actin-binding sites, and the ASB2alpha-resistant filamin mutant is defective in targeting to F-actin-rich structures in cells.	Lysine	6-13	filamin C	Homo sapiens	95-102
20631708-3	2010	Here we show that mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations.	Lysine	56-62	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	149-154
25761473-1	2016	PURPOSE: Heterochromatin protein 1gamma (HP1gamma) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA.	Lysine	92-98	chromobox 3	Homo sapiens	41-49
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	homeobox A10	Homo sapiens	52-58
27096066-7	2016	At local site, mRNA and protein levels of lung-derived pro-inflammatory cytokines IL-33 and TSLP were markedly down-regulated following SLIT that was associated with marked enrichment of trimethylated lysine 27 of histone H3 at promoter regions of these two cytokines.	Lysine	201-207	thymic stromal lymphopoietin	Mus musculus	92-96
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	lysine acetyltransferase 2B	Homo sapiens	96-100
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	homeobox A10	Homo sapiens	151-157
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	lysine acetyltransferase 2B	Homo sapiens	158-162
20691902-3	2010	We find that PRC1"s microtubule binding is mediated by a structured domain with a spectrin-fold and an unstructured Lys/Arg-rich domain.	Lysine	116-119	protein regulator of cytokinesis 1	Homo sapiens	13-17
20519503-2	2010	Remarkably, TCRalpha has a cytosolic tail of only five amino acid residues (i.e. RLWSS), none of which is the conventional ubiquitin acceptor, lysine.	Lysine	143-149	T cell receptor alpha constant	Homo sapiens	12-20
26631469-4	2015	We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1.	Lysine	146-149	kallikrein related peptidase 10	Homo sapiens	171-175
20603103-3	2010	The attachment of Nedd8 to its substrates occurs via a process analogous to ubiquitin transfer, involving a Nedd8 E1 activating enzyme and a Nedd8 E2 conjugating enzyme, Ubc12, which transfers Nedd8 onto lysine residues of target proteins.	Lysine	204-210	NEDD8 ubiquitin like modifier	Homo sapiens	18-23
20603103-3	2010	The attachment of Nedd8 to its substrates occurs via a process analogous to ubiquitin transfer, involving a Nedd8 E1 activating enzyme and a Nedd8 E2 conjugating enzyme, Ubc12, which transfers Nedd8 onto lysine residues of target proteins.	Lysine	204-210	NEDD8 ubiquitin like modifier	Homo sapiens	108-113
20603103-3	2010	The attachment of Nedd8 to its substrates occurs via a process analogous to ubiquitin transfer, involving a Nedd8 E1 activating enzyme and a Nedd8 E2 conjugating enzyme, Ubc12, which transfers Nedd8 onto lysine residues of target proteins.	Lysine	204-210	NEDD8 ubiquitin like modifier	Homo sapiens	108-113
20603103-3	2010	The attachment of Nedd8 to its substrates occurs via a process analogous to ubiquitin transfer, involving a Nedd8 E1 activating enzyme and a Nedd8 E2 conjugating enzyme, Ubc12, which transfers Nedd8 onto lysine residues of target proteins.	Lysine	204-210	NEDD8 ubiquitin like modifier	Homo sapiens	108-113
24244184-6	2013	In this study, furthermore, we have focused on promoters containing the nuclear respiratory factor 1 (NRF1) motif as the cardinal cis-regulatory element and have identified the pervasive association of NRF1 with the cofactor lysine-specific demethylase 1 (LSD1/KDM1A).	Lysine	225-231	nuclear respiratory factor 1	Homo sapiens	72-100
24244184-6	2013	In this study, furthermore, we have focused on promoters containing the nuclear respiratory factor 1 (NRF1) motif as the cardinal cis-regulatory element and have identified the pervasive association of NRF1 with the cofactor lysine-specific demethylase 1 (LSD1/KDM1A).	Lysine	225-231	nuclear respiratory factor 1	Homo sapiens	102-106
24244184-6	2013	In this study, furthermore, we have focused on promoters containing the nuclear respiratory factor 1 (NRF1) motif as the cardinal cis-regulatory element and have identified the pervasive association of NRF1 with the cofactor lysine-specific demethylase 1 (LSD1/KDM1A).	Lysine	225-231	nuclear respiratory factor 1	Homo sapiens	202-206
24032713-7	2013	We hypothesized that DeltaS2 PRLR played an important pathogenic role in prostate cancer through, at least partly, alterations in the expression of EZH2 and the trimethylation of histone 3 on lysine 27.	Lysine	192-198	prolactin receptor	Homo sapiens	29-33
26248577-1	2015	Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1.4K26) and plays a crucial role in the regulation of gene expression as well as in heterochromatin formation.	Lysine	148-154	lysine (K)-specific demethylase 4C	Mus musculus	51-56
24095733-2	2013	Here, we report the crystal structure of the PRDM9 methyltransferase domain in complex with a histone H3 peptide dimethylated on lysine 4 (H3K4me2) and S-adenosylhomocysteine (AdoHcy), which provides insights into the methyltransferase activity of PRDM proteins.	Lysine	129-135	PR/SET domain 9	Homo sapiens	45-50
24095733-3	2013	We show that the genuine substrate of PRDM9 is histone H3 lysine 4 (H3K4) and that the enzyme possesses mono-, di-, and trimethylation activities.	Lysine	58-64	PR/SET domain 9	Homo sapiens	38-43
20622853-4	2010	Here we provide multiple lines of evidence establishing PHF8 as the first mono-methyl histone H4 lysine 20 (H4K20me1) demethylase, with additional activities towards histone H3K9me1 and me2.	Lysine	97-103	PHD finger protein 8	Homo sapiens	56-60
20622854-0	2010	PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.	Lysine	25-31	PHD finger protein 8	Homo sapiens	0-4
26248577-1	2015	Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1.4K26) and plays a crucial role in the regulation of gene expression as well as in heterochromatin formation.	Lysine	148-154	lysine (K)-specific demethylase 4C	Mus musculus	73-78
26248577-1	2015	Gene amplified in squamous cell carcinoma (SCC) 1 (GASC1), also known as KDM4C/JMJD2C, encodes a histone demethylase that specifically demethylates lysine residues (H3K9, H3K36, and H1.4K26) and plays a crucial role in the regulation of gene expression as well as in heterochromatin formation.	Lysine	148-154	lysine (K)-specific demethylase 4C	Mus musculus	79-85
26416882-0	2015	BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation.	Lysine	110-116	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	0-4
20555324-5	2010	Here we identify the ASH-2 trithorax complex, which trimethylates histone H3 at lysine 4 (H3K4), as a regulator of lifespan in Caenorhabditis elegans in a directed RNA interference (RNAi) screen in fertile worms.	Lysine	80-86	B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2	Caenorhabditis elegans	21-26
23974797-10	2013	The lysine 437 ubiquitination of Beclin 1 enhances the association with Vps34 to promote Vps34 activity.	Lysine	4-10	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	72-77
23974797-10	2013	The lysine 437 ubiquitination of Beclin 1 enhances the association with Vps34 to promote Vps34 activity.	Lysine	4-10	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	89-94
26416882-6	2015	Analysis of histone H3 within the Nanog proximal enhancer revealed that H3 lysine 9/14 (H3K9/14) acetylation increased in BRG1-depleted embryos and ESCs.	Lysine	75-81	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	122-126
26517514-4	2015	Subsequent investigations showed that CHD5 was epigenetically silenced by polycomb repressive complex 2 (PRC2)-mediated the trimethylation of histone H3 at lysine 27 (H3K27me3) in HCC cells.	Lysine	156-162	chromodomain helicase DNA binding protein 5	Homo sapiens	38-42
23160374-6	2013	Sumoylation of CLOCK occurred at two lysine residues, K67 and K851.	Lysine	37-43	clock circadian regulator	Homo sapiens	15-20
20603083-3	2010	Set9 methylates E2F1 at lysine-185, which prevents E2F1 accumulation during DNA damage and activation of its proapoptotic target gene p73.	Lysine	24-30	tumor protein p73	Homo sapiens	134-137
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	bromodomain testis associated	Rattus norvegicus	161-165
20445443-12	2010	The results showed that S-2 enhanced this activation, whereas lysine or 6-AH which were active in enhancing the activation of Glu-Plg were not active using Lys-Plg indicating that the site of enhancement by lysine or 6-AH was during the initial phase.	Lysine	62-68	plasminogen	Homo sapiens	130-133
20445443-12	2010	The results showed that S-2 enhanced this activation, whereas lysine or 6-AH which were active in enhancing the activation of Glu-Plg were not active using Lys-Plg indicating that the site of enhancement by lysine or 6-AH was during the initial phase.	Lysine	207-213	plasminogen	Homo sapiens	130-133
23979357-4	2013	Transfection of TREX1 deletion constructs into human cells demonstrated that this sequence is required for ubiquitination at multiple lysine residues through a "non-canonical" ubiquitin linkage.	Lysine	134-140	three prime repair exonuclease 1	Homo sapiens	16-21
23979357-6	2013	Cotransfection studies indicated that ubiquilin 1 localizes TREX1 to cytosolic punctate structures dependent upon the TREX1 CTR and lysines within the TREX1 catalytic core.	Lysine	132-139	three prime repair exonuclease 1	Homo sapiens	60-65
23770046-3	2013	Here we demonstrated that EVI1 is post-translationally modified by SUMO1 at lysine residues 533, 698 and 874.	Lysine	76-82	small ubiquitin like modifier 1	Homo sapiens	67-72
20543557-8	2010	Furthermore, downregulation of BMI1 was accompanied by a decrease in histone 2A lysine 119 ubiquitination (H2AK119Ub), which is catalyzed by BMI1 containing polycomb repressive complex 1.	Lysine	80-86	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	31-35
26551560-1	2015	Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development.	Lysine	120-126	euchromatic histone lysine N-methyltransferase 2	Mus musculus	96-99
20543557-8	2010	Furthermore, downregulation of BMI1 was accompanied by a decrease in histone 2A lysine 119 ubiquitination (H2AK119Ub), which is catalyzed by BMI1 containing polycomb repressive complex 1.	Lysine	80-86	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	141-145
26545110-1	2015	Ubiquitination of the replication clamp proliferating cell nuclear antigen (PCNA) at the conserved residue lysine (K)164 triggers postreplicative repair (PRR) to fill single-stranded gaps that result from stalled DNA polymerases.	Lysine	107-113	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	40-74
20571979-3	2010	Activation of mGluR2 has been associated with the antipsychotic-like behavioral effects of LY-404039, as indicated by experiments using mGluR2-/- and mGluR3-/- mice.	Lysine	91-93	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	14-20
20571979-3	2010	Activation of mGluR2 has been associated with the antipsychotic-like behavioral effects of LY-404039, as indicated by experiments using mGluR2-/- and mGluR3-/- mice.	Lysine	91-93	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	136-142
23845993-5	2013	Time resolved anisotropy decay measurements supported the idea that cofilin and profilin changed similarly the dynamics around the fluorescently labeled Cys-374 and Lys-61 residues in subdomains 1 and 2, respectively.	Lysine	165-168	cofilin 1	Homo sapiens	68-75
26545110-1	2015	Ubiquitination of the replication clamp proliferating cell nuclear antigen (PCNA) at the conserved residue lysine (K)164 triggers postreplicative repair (PRR) to fill single-stranded gaps that result from stalled DNA polymerases.	Lysine	107-113	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	76-80
26249628-0	2015	Lysine-doped polypyrrole/spider silk protein/poly(l-lactic) acid containing nerve growth factor composite fibers for neural application.	Lysine	0-6	nerve growth factor	Rattus norvegicus	76-95
23624357-2	2013	Thrombin-activatable fibrinolysis inhibitor (TAFI) has an antifibrinolytic effect as it can remove partially degraded fibrin C-terminal lysine residues and reduce plasmin formation.	Lysine	136-142	carboxypeptidase B2	Homo sapiens	0-43
23624357-2	2013	Thrombin-activatable fibrinolysis inhibitor (TAFI) has an antifibrinolytic effect as it can remove partially degraded fibrin C-terminal lysine residues and reduce plasmin formation.	Lysine	136-142	carboxypeptidase B2	Homo sapiens	45-49
19774489-7	2010	Cells expressing the lysine mutated SRA-II also demonstrated a significant decrease in their uptake of AcLDL.	Lysine	21-27	macrophage scavenger receptor 1	Mus musculus	36-42
26249628-1	2015	Lysine-doped polypyrrole (PPy)/regenerated spider silk protein (RSSP)/poly(l-lactic) acid (PLLA)/nerve growth factor (NGF) (L-PRPN) composite scaffold was fabricated by co-axial electrospraying and electrospinning.	Lysine	0-6	nerve growth factor	Rattus norvegicus	97-116
26303527-2	2015	Acetylation is controlled by complexes containing opposing lysine and histone acetyltransferase (KAT and HAT) and deacetylase (KDAC and HDAC) activities.	Lysine	59-65	transmembrane serine protease 11D	Homo sapiens	105-108
20421419-5	2010	Our biochemical analysis revealed specific association of the PHF8 PHD with histone H3 trimethylated at lysine 4 (H3K4me3).	Lysine	104-110	PHD finger protein 8	Homo sapiens	62-66
23884086-5	2013	Several inhibitors of IRE1 have recently been reported, each containing an aldehyde moiety that forms an unusual, highly selective Schiff base with a single key lysine (K907) within the RNase domain.	Lysine	161-167	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	22-26
26503325-10	2015	Lacking all of lysine residues of pVHL result in resistance to ubiquitination thereby increase its stability.	Lysine	15-21	von Hippel-Lindau tumor suppressor	Homo sapiens	34-38
24056301-5	2013	Specifically, ubiquitylation at Lys 47 sterically inhibits RALB binding to EXO84, while facilitating its interaction with SEC5.	Lysine	32-35	exocyst complex component 2	Homo sapiens	122-126
20439492-9	2010	The defects in adherens junction protein distribution required integrin signaling as E-cadherin and p120-catenin were restored at cell/cell contacts when cells were plated on poly-l-lysine.	Lysine	175-188	catenin delta 1	Homo sapiens	100-112
26503415-4	2015	KDM5C is a member of the family of JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4).	Lysine	112-118	lysine demethylase 5C	Homo sapiens	0-5
20543837-5	2010	Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions.	Lysine	130-136	transcription factor 3	Homo sapiens	17-20
24046418-9	2013	Moreover, potential alternative pathways of lysine catabolism that depend on l-amino acid oxidase (AAOX) and on lysyl oxidase (LYLOX) were considered.	Lysine	44-50	interleukin 4 induced 1	Homo sapiens	77-97
24046418-9	2013	Moreover, potential alternative pathways of lysine catabolism that depend on l-amino acid oxidase (AAOX) and on lysyl oxidase (LYLOX) were considered.	Lysine	44-50	interleukin 4 induced 1	Homo sapiens	99-103
26503415-4	2015	KDM5C is a member of the family of JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4).	Lysine	135-141	lysine demethylase 5C	Homo sapiens	0-5
24046418-15	2013	The activity of AAOX did increase (P &lt; 0.05) in birds fed a lysine-adequate diets compared with those fed a lysine-deficient diet.	Lysine	63-69	interleukin 4 induced 1	Homo sapiens	16-20
24046418-15	2013	The activity of AAOX did increase (P &lt; 0.05) in birds fed a lysine-adequate diets compared with those fed a lysine-deficient diet.	Lysine	111-117	interleukin 4 induced 1	Homo sapiens	16-20
28455045-2	2015	Reducing sugars, xylose, ribose, fructose, glucose, and non-reducing sucrose were reacted with glycine (Xyl-Gly, Rib-Gly, Fru-Gly, Glc-Gly, and Suc-Gly), or lysine (Xyl-Lys, Rib-Lys, Fru-Lys, Glc-Lys, and Suc-Lys), respectively, at temperatures of 150 C and 180 C for time periods ranging from 5 to 60min.	Lysine	157-163	zinc finger and BTB domain containing 22	Homo sapiens	122-125
23973329-5	2013	In addition, the TGF-beta receptor-TRAF4 interaction triggers Lys 63-linked TRAF4 polyubiquitylation and subsequent activation of the TGF-beta-activated kinase (TAK)1.	Lysine	62-65	TNF receptor associated factor 4	Homo sapiens	35-40
23973329-5	2013	In addition, the TGF-beta receptor-TRAF4 interaction triggers Lys 63-linked TRAF4 polyubiquitylation and subsequent activation of the TGF-beta-activated kinase (TAK)1.	Lysine	62-65	TNF receptor associated factor 4	Homo sapiens	76-81
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	tripartite motif containing 25	Homo sapiens	31-37
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	interferon beta 1	Homo sapiens	279-287
20109579-8	2010	Furthermore, we show that though the level of methyltransferases enzymes was increased, the status of H3 three-methylation at lysine 27 (H3K27me(3)), associated with gene repression on the promoter of Cyclin D1, was lower.	Lysine	126-132	cyclin D1	Homo sapiens	201-210
24040206-5	2013	The carboxyl-terminal five amino acids, particularly Lysine(122) and Leucine(123) of human LC3B play a major role in the faster migration of unprocessed LC3B, rendering it indistinguishable from LC3B-II in Wb assays.	Lysine	53-59	microtubule associated protein 1 light chain 3 beta	Homo sapiens	91-95
24040206-5	2013	The carboxyl-terminal five amino acids, particularly Lysine(122) and Leucine(123) of human LC3B play a major role in the faster migration of unprocessed LC3B, rendering it indistinguishable from LC3B-II in Wb assays.	Lysine	53-59	microtubule associated protein 1 light chain 3 beta	Homo sapiens	153-157
26722485-1	2015	KDM4A, KDM4B and KDM4D are lysine demethylases which demethylate H3 at lysine K9 and K36 sites, additionally KDM4D also the H1.4 linker histone at K26 lysine.	Lysine	27-33	lysine demethylase 4D	Homo sapiens	17-22
24040206-5	2013	The carboxyl-terminal five amino acids, particularly Lysine(122) and Leucine(123) of human LC3B play a major role in the faster migration of unprocessed LC3B, rendering it indistinguishable from LC3B-II in Wb assays.	Lysine	53-59	microtubule-associated protein 1 light chain 3 beta	Mus musculus	153-157
20144948-4	2010	A Lys residue (679 in human POLN) of particular interest was identified in the conserved "O-helix" of motif 4 in the fingers sub-domain.	Lysine	2-5	DNA polymerase nu	Homo sapiens	28-32
26722485-1	2015	KDM4A, KDM4B and KDM4D are lysine demethylases which demethylate H3 at lysine K9 and K36 sites, additionally KDM4D also the H1.4 linker histone at K26 lysine.	Lysine	27-33	lysine demethylase 4D	Homo sapiens	109-114
26256950-6	2015	Inhibition of platelet p300 abrogated CRP-stimulated lysine acetylation of actin, filamin, and cortactin, as well as F-actin polymerization, integrin activation, and platelet aggregation.	Lysine	53-59	E1A binding protein p300	Homo sapiens	23-27
20399742-4	2010	Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.	Lysine	226-232	nerve growth factor	Rattus norvegicus	61-64
20399742-4	2010	Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.	Lysine	226-232	nerve growth factor	Rattus norvegicus	111-114
24265859-5	2013	We report here that the direct activation of P300/CBP-associated factor (PCAF) by the histone acetylase activator pentadecylidenemalonate 1b (SPV-106) induced Lysine acetylation in the wound area.	Lysine	159-165	K(lysine) acetyltransferase 2B	Mus musculus	45-71
24265859-5	2013	We report here that the direct activation of P300/CBP-associated factor (PCAF) by the histone acetylase activator pentadecylidenemalonate 1b (SPV-106) induced Lysine acetylation in the wound area.	Lysine	159-165	K(lysine) acetyltransferase 2B	Mus musculus	73-77
23673479-7	2013	In total, significantly increased risk of developing lung cancer was found in the following combinations of genotypes: XPD Lys/Gln+XPC Lys/Lys (OR = 1.62; p = 0.04), XRCC1 Gln/Gln+hOGG1 Ser/Ser (OR = 2.14; p = 0.02).	Lysine	135-138	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	131-134
26168137-1	2015	The Sfp-type 4"-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including alpha-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and polyketide secondary metabolites, respectively.	Lysine	166-172	plastid phosphate/phosphoenolpyruvate translocator 1	Zea mays	48-52
23673479-7	2013	In total, significantly increased risk of developing lung cancer was found in the following combinations of genotypes: XPD Lys/Gln+XPC Lys/Lys (OR = 1.62; p = 0.04), XRCC1 Gln/Gln+hOGG1 Ser/Ser (OR = 2.14; p = 0.02).	Lysine	135-138	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	131-134
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	115-118	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	172-175
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	115-118	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	172-175
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	127-130	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	127-130	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
20351106-10	2010	We demonstrate that neutralization of a lysine residue (Lys(245)) located at the C-terminal end of transmembrane domain 4 by mutation to alanine abolishes gating by pH(i).	Lysine	40-46	glucose-6-phosphate isomerase	Homo sapiens	165-170
20351106-10	2010	We demonstrate that neutralization of a lysine residue (Lys(245)) located at the C-terminal end of transmembrane domain 4 by mutation to alanine abolishes gating by pH(i).	Lysine	56-59	glucose-6-phosphate isomerase	Homo sapiens	165-170
20351106-11	2010	We postulate that this lysine acts as an intracellular pH sensor as its mutation to histidine acid-shifts the pH(i)-dependence curve of TASK-2 as expected from its lower pK(a).	Lysine	23-29	glucose-6-phosphate isomerase	Homo sapiens	110-115
23903439-1	2013	NEDD8 (NEURAL PRECURSOR CELL-EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED PROTEIN8) is an evolutionarily conserved 8-kD protein that is closely related to ubiquitin and that can be conjugated like ubiquitin to specific lysine residues of target proteins in eukaryotes.	Lysine	216-222	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	7-38
20534339-1	2010	p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation.	Lysine	78-84	E1A binding protein p300	Homo sapiens	0-4
26111452-0	2015	Role of an arginine-lysine rich motif in maturation and trafficking of CD19.	Lysine	20-26	CD19 molecule	Homo sapiens	71-75
20501938-0	2010	TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.	Lysine	23-29	TNF alpha induced protein 3	Homo sapiens	10-13
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	69-72	erb-b2 receptor tyrosine kinase 3	Homo sapiens	77-81
23839075-2	2013	Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation.	Lysine	83-89	sirtuin 6	Homo sapiens	0-5
20304918-7	2010	TAX1BP1 and A20 blocked antiviral signaling by disrupting Lys(63)-linked polyubiquitination of TBK1-IKKi independently of the A20 deubiquitination domain.	Lysine	58-61	tumor necrosis factor, alpha-induced protein 3	Mus musculus	12-15
26111452-3	2015	The current study explored the contribution of an arginine-lysine rich motif, present in the membrane-proximal cytoplasmic domain of CD19, for the maturation and trafficking of this molecule.	Lysine	59-65	CD19 molecule	Homo sapiens	133-137
20304918-7	2010	TAX1BP1 and A20 blocked antiviral signaling by disrupting Lys(63)-linked polyubiquitination of TBK1-IKKi independently of the A20 deubiquitination domain.	Lysine	58-61	TANK-binding kinase 1	Mus musculus	95-99
26260792-8	2015	Mutation of the highly conserved Gln-758, which chelates a nucleotide-associated Mg(2+) ion, eliminated catalytic activity, whereas loss of the highly conserved Lys-722 and Arg-592 decreased kcat values for kinase and ATPase activities by 3-6-fold.	Lysine	161-164	dynein axonemal heavy chain 8	Homo sapiens	218-224
20439426-2	2010	Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development.	Lysine	201-204	jumonji and AT-rich interaction domain containing 2	Homo sapiens	54-60
26320860-2	2015	4-((6-(Cyclohexylmethoxy)-9H-purin-2-yl)amino)benzenesulfonamide (NU6102) is a potent and selective ATP-competitive inhibitor of CDK2 in which the sulfonamide moiety is positioned close to a pair of lysine residues.	Lysine	199-205	cyclin dependent kinase 2	Homo sapiens	129-133
23940364-1	2013	Large deletions in the first intron of the With No lysine (K) 1 (WNK1) gene are responsible for Familial Hyperkalemic Hypertension (FHHt), a rare form of human hypertension associated with hyperkalemia and hyperchloremic metabolic acidosis.	Lysine	51-57	WNK lysine deficient protein kinase 1	Homo sapiens	65-69
25998543-4	2015	A moderate reduction of citrate synthase and isocitrate dehydrogenase activities was observed only in the striatum from 30-day-old Gcdh-/- animals submitted to a high Lys chow.	Lysine	167-170	citrate synthase	Mus musculus	24-40
23941555-4	2013	Ctf7 contains an acetyltransferase domain and a zinc finger motif and acetylates conserved lysine residues in the Smc3 subunit of cohesin.	Lysine	91-97	protein CTF7	Arabidopsis thaliana	0-4
23904479-1	2013	Lysine methylation of the p65 subunit of nuclear factor kappaB (NF-kappaB) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines.	Lysine	0-6	RELA proto-oncogene, NF-kB subunit	Homo sapiens	26-29
20082324-4	2010	We show here that in a Drosophila CtBP mutant background, intergenic transcripts are induced across several PRE sequences and this corresponds to reduced DNA binding by PcG proteins Pleiohomeotic (PHO) and Polycomb (Pc), and reduced trimethylation of histone H3 on lysine 27, a hallmark of PcG repression.	Lysine	265-271	Polycomb	Drosophila melanogaster	169-172
20082324-4	2010	We show here that in a Drosophila CtBP mutant background, intergenic transcripts are induced across several PRE sequences and this corresponds to reduced DNA binding by PcG proteins Pleiohomeotic (PHO) and Polycomb (Pc), and reduced trimethylation of histone H3 on lysine 27, a hallmark of PcG repression.	Lysine	265-271	Polycomb	Drosophila melanogaster	169-171
26329457-3	2015	Sir2 partially represses the transcription of lifespan-associated genes, such as PMA1 (encoding an H(+)-ATPase) and many ribosomal protein genes, through deacetylation of Lys 16 of histone H4 in the promoter regions of these genes.	Lysine	171-174	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	81-85
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Lysine	116-119	glycolipid transfer protein	Homo sapiens	37-41
23722415-6	2013	Jejunal mRNA levels for the b(0,+)-AT, y(+)LAT1 and CAT1 genes were greater (P &lt; 0.05) in the Zein + LYS group than in the control, and the opposite was observed for CAT1.	Lysine	104-107	solute carrier family 7 member 1	Sus scrofa	52-56
23722415-6	2013	Jejunal mRNA levels for the b(0,+)-AT, y(+)LAT1 and CAT1 genes were greater (P &lt; 0.05) in the Zein + LYS group than in the control, and the opposite was observed for CAT1.	Lysine	104-107	solute carrier family 7 member 1	Sus scrofa	169-173
26183023-2	2015	Previously, we found that p53 interacts with KAISO, and acetylation of p53 lysine residues by p300 is modulated by KAISO.	Lysine	75-81	E1A binding protein p300	Homo sapiens	94-98
23597856-2	2013	The activity of NF-kappaB is regulated in part by acetylation of its p65 subunit at lysine 310, which is required for transcription complex formation.	Lysine	84-90	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
20428248-5	2010	We further identified 6 lysine residues in WRN that are subject to acetylation.	Lysine	24-30	WRN RecQ like helicase	Homo sapiens	43-46
20428248-8	2010	CBP dramatically increases the half-life of wild type WRN, while mutation of these 6 lysine residues (WRN-6KR) abrogates this increase.	Lysine	85-91	WRN RecQ like helicase	Homo sapiens	102-105
20139424-8	2010	Overall, our results show and suggest that multiple H4, H2A, and H3 residues contribute to and form a Set2 docking/recognition site on the nucleosomal surface so that proper Set2-mediated H3 Lys(36) di- and trimethylation, histone acetylation, and transcriptional elongation can occur.	Lysine	191-194	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	102-106
20139424-8	2010	Overall, our results show and suggest that multiple H4, H2A, and H3 residues contribute to and form a Set2 docking/recognition site on the nucleosomal surface so that proper Set2-mediated H3 Lys(36) di- and trimethylation, histone acetylation, and transcriptional elongation can occur.	Lysine	191-194	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	174-178
26377079-8	2015	The uptake was Na+-independent, and was inhibited by L-ornithine, L-arginine, and L-lysine, suggesting the involvement of CAT1 in L-ornithine transport at the inner BRB.	Lysine	82-90	solute carrier family 7 member 1	Rattus norvegicus	122-126
23900545-1	2013	Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system.	Lysine	32-38	Polycomb	Drosophila melanogaster	57-65
23900545-1	2013	Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system.	Lysine	32-38	Polycomb	Drosophila melanogaster	146-154
20159987-3	2010	The ubiquitin chains assembled on Pex29 in vivo by Ufd2 mainly contain Lys-48 linkages.	Lysine	71-74	ubiquitin	Saccharomyces cerevisiae S288C	4-13
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Lysine	52-55	serine protease 3	Homo sapiens	39-50
20159987-3	2010	The ubiquitin chains assembled on Pex29 in vivo by Ufd2 mainly contain Lys-48 linkages.	Lysine	71-74	Pex29p	Saccharomyces cerevisiae S288C	34-39
23644046-6	2013	p300 plays a complex role in FOXP3 acetylation, as it could also acetylate a subset of four Lys residues that repressively regulate total FOXP3 acetylation.	Lysine	92-95	E1A binding protein p300	Homo sapiens	0-4
23644046-6	2013	p300 plays a complex role in FOXP3 acetylation, as it could also acetylate a subset of four Lys residues that repressively regulate total FOXP3 acetylation.	Lysine	92-95	forkhead box P3	Homo sapiens	29-34
20167472-5	2010	Interestingly the histone H4 lysine 16 specific MOF histone acetyl transferase, a key MSL member that hyper-acetylates the male X chromosome, is also involved in gene regulation beyond dosage compensation.	Lysine	29-35	male-specific lethal 3	Drosophila melanogaster	86-89
26287632-3	2015	We demonstrate our method by measuring the conformational changes that occur upon ligand binding with three well-characterized proteins labeled at lysine residues: calmodulin (CaM), maltose-binding protein (MBP), and dihydrofolate reductase (DHFR).	Lysine	147-153	myelin basic protein	Homo sapiens	207-210
20604837-1	2010	OBJECTIVES: Lysyl hydroxylase 2 (LH2), an isoform of hydroxylase, catalyses the hydroxylation of lysine residues in the telopeptide of collagen to form stable and irreversible cross-linkages in collagen.	Lysine	97-103	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	12-31
20604837-1	2010	OBJECTIVES: Lysyl hydroxylase 2 (LH2), an isoform of hydroxylase, catalyses the hydroxylation of lysine residues in the telopeptide of collagen to form stable and irreversible cross-linkages in collagen.	Lysine	97-103	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	33-36
23644046-6	2013	p300 plays a complex role in FOXP3 acetylation, as it could also acetylate a subset of four Lys residues that repressively regulate total FOXP3 acetylation.	Lysine	92-95	forkhead box P3	Homo sapiens	138-143
23740527-5	2013	Western blot analysis using an antibody against acetyl-nuclear factor-kappaB (NF-kappaB) demonstrated that PCAF mediated the Abeta-induced activation of NF-kappaB by acetylation at Lys-122.	Lysine	181-184	K(lysine) acetyltransferase 2B	Mus musculus	107-111
26116533-2	2015	In agreement with a previous study, we validate Ubc9 to facilitate SUMOylation of hRXRalpha at lysine 108 but note this modification to occur for all isoforms rather than specifically with SUMO1 and to preferentially occur with the unliganded form of hRXRalpha.	Lysine	95-101	ubiquitin conjugating enzyme E2 I	Homo sapiens	48-52
20231782-12	2010	Significantly high levels of mouse IP-10 in BALB/c mice was also detected when SARS-CoV-infected mice were treated with the interferon inducer, polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose (poly IC:LC).	Lysine	200-213	chemokine (C-X-C motif) ligand 10	Mus musculus	35-40
26101372-6	2015	Ube2W targets multiple TRIM5alpha internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal amino group, which is instead alphaN-acetylated in cells.	Lysine	43-50	tripartite motif containing 5	Homo sapiens	23-33
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	166-172	lipoprotein(a)	Homo sapiens	72-86
24137335-1	2013	Human males absent on the first (hMOF), a human ortholog of the Drosophila MOF protein, is responsible for histone H4 lysine 16 (H4K16) acetylation in human cells.	Lysine	118-124	lysine acetyltransferase 8	Homo sapiens	33-37
24137335-1	2013	Human males absent on the first (hMOF), a human ortholog of the Drosophila MOF protein, is responsible for histone H4 lysine 16 (H4K16) acetylation in human cells.	Lysine	118-124	lysine acetyltransferase 8	Homo sapiens	34-37
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	166-172	lipoprotein(a)	Homo sapiens	125-130
25959059-6	2015	Three lysines K87, K98 and K224 of hnRNP F are potential targets of the mutually exclusive acetylation or ubiquitination (K(Ac/Ub)) in the protein modification database PhosphoSitePlus.	Lysine	6-13	heterogeneous nuclear ribonucleoprotein F	Homo sapiens	35-42
19787286-7	2010	In regard to the mechanism of mucin expression, we have recently reported that MUC1, MUC2, MUC4, and MUC5AC gene expression is regulated by epigenetics (DNA methylation and histone H3 lysine 9 modification) in cancer cell lines, including PDAC cells.	Lysine	184-190	LOC100508689	Homo sapiens	30-35
19787286-7	2010	In regard to the mechanism of mucin expression, we have recently reported that MUC1, MUC2, MUC4, and MUC5AC gene expression is regulated by epigenetics (DNA methylation and histone H3 lysine 9 modification) in cancer cell lines, including PDAC cells.	Lysine	184-190	mucin 1, cell surface associated	Homo sapiens	79-83
19787286-7	2010	In regard to the mechanism of mucin expression, we have recently reported that MUC1, MUC2, MUC4, and MUC5AC gene expression is regulated by epigenetics (DNA methylation and histone H3 lysine 9 modification) in cancer cell lines, including PDAC cells.	Lysine	184-190	mucin 4, cell surface associated	Homo sapiens	91-95
23879974-8	2013	In neurons, it co-immunoprecipitates with SUZ12, a key component of the Polycomb Repressive Complex 2 (PRC2) that regulates a number of important cellular processes, including gene silencing via histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	206-212	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	42-47
25959059-11	2015	Thus, the deacetylase inhibitor TSA enhances hnRNP F stability through the K(Ac/Ub) lysines, with some of them essential for its regulation of alternative splicing.	Lysine	84-91	heterogeneous nuclear ribonucleoprotein F	Homo sapiens	45-52
23581279-2	2013	We discovered that Jak2 is SUMOylated on multiple lysine residues by SUMO2/3 (small ubiquitin-related modifier 2/3) chains.	Lysine	50-56	Janus kinase 2	Homo sapiens	19-23
26205499-7	2015	At the molecular level, Lys(61) of PAQR3 is targeted by DDB2 for ubiquitination.	Lysine	24-27	damage specific DNA binding protein 2	Homo sapiens	56-60
23874440-9	2013	Histidine mimicked the effect of protease inhibitors causing an almost complete nNOS inhibition in cells incubated additionally in lysine that depletes the exchangeable arginine pool.	Lysine	131-137	nitric oxide synthase 1	Homo sapiens	80-84
20380799-5	2010	PHI treatment resulted in increased acetylation of histone H3 and H4 , elevated level of histone H3 lysine 4 methylation, and decreased level of histone H3 lysine 9 methylation.	Lysine	100-106	glucose-6-phosphate isomerase	Homo sapiens	0-3
20380799-5	2010	PHI treatment resulted in increased acetylation of histone H3 and H4 , elevated level of histone H3 lysine 4 methylation, and decreased level of histone H3 lysine 9 methylation.	Lysine	156-162	glucose-6-phosphate isomerase	Homo sapiens	0-3
25986499-8	2015	Unexpectedly, we find a pervasive distribution of histone H2A ubiquitylated at lysine 118 (H2AK118ub) outside of canonical PcG target regions, dependent on the RING/Sce subunit of PRC1-type complexes.	Lysine	79-85	protein regulator of cytokinesis 1	Homo sapiens	180-184
19955185-4	2010	In this report, we demonstrate that hPPARalpha is SUMOylated by SUMO-1 on lysine 185 in the hinge region.	Lysine	74-80	small ubiquitin like modifier 1	Homo sapiens	64-70
23512198-8	2013	Lysine(166) within Rac1 was identified as a polyubiquitination acceptor site.	Lysine	0-6	Rac family small GTPase 1	Mus musculus	19-23
23696636-2	2013	In vitro, Ube2w is nonreactive with free lysine yet readily ubiquitinates substrate.	Lysine	41-47	ubiquitin like modifier activating enzyme 7	Homo sapiens	10-14
19961857-8	2010	Analysis of CYP24A1"s proximal surface identifies the determinants of adrenodoxin recognition as a constellation of conserved residues from helices K, K"", and L that converge with an adjacent lysine-rich loop for binding the redox protein.	Lysine	193-199	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	12-19
26037928-7	2015	FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation.	Lysine	65-68	F-box and leucine rich repeat protein 2	Homo sapiens	0-5
25999347-3	2015	In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1 to the site of DNA damage promotes local H3K4me2 demethylation and ubiquitination of H2A/H2AX, facilitating 53BP1 recruitment to sites of DNA damage.	Lysine	63-69	ring finger protein 168	Homo sapiens	27-33
20133869-5	2010	We demonstrate that the major ISG15 acceptor site in the NS1A protein in infected cells is a critical lysine residue (K41) in the N-terminal RNA-binding domain (RBD).	Lysine	102-108	ISG15 ubiquitin like modifier	Homo sapiens	30-35
19927155-7	2010	We find that direct binding of p53 to importin-alpha3 depends on the positive charge contributed by lysine residues 319-321 within NLS I.	Lysine	100-106	karyopherin subunit alpha 3	Homo sapiens	38-53
19927155-11	2010	Thus, under normal growth conditions, ubiquitination of Lys 319-321 negatively regulates p53-importin-alpha3 binding, thereby restraining p53 import.	Lysine	56-59	karyopherin subunit alpha 3	Homo sapiens	93-108
23577621-2	2013	The AP lyase reaction is catalysed by imine formation with an active site lysine residue, and a covalent intermediate can be trapped in the presence of NaBH4.	Lysine	74-80	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-12
25937317-3	2015	Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg.	Lysine	21-27	plasminogen	Homo sapiens	143-146
23547170-4	2013	Here, we used chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) to measure genome-wide changes in histone H3 acetylation at lysine 27 (H3K27ac), a marker of active enhancers, in unstimulated HUVECs and HUVECs stimulated with VEGFA for 1, 4, and 12 h. We show that sites with the greatest H3K27ac change upon stimulation were associated tightly with EP300, a histone acetyltransferase.	Lysine	154-160	E1A binding protein p300	Homo sapiens	379-384
23809134-2	2013	Proteolytic cleavage of fibrin by plasmin generates C-terminal lysine residues capable of binding both plasminogen and the plasminogen activator, thereby stimulating plasminogen activator-mediated plasminogen activation and propagating fibrinolysis.	Lysine	63-69	plasminogen	Homo sapiens	34-41
19948738-7	2010	Thus, Lys(842) is critical for the known functions of the AI and also enables two additional functions of the AI as newly identified here: suppression of electron transfer to FMN and control of the conformational equilibrium of the nNOS reductase domain.	Lysine	6-9	nitric oxide synthase 1	Homo sapiens	232-236
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Lysine	38-41	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	110-114
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Lysine	38-41	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	159-163
25903134-6	2015	Together with structural docking studies, our data suggest that FVIII interacts with LRP1 via an extended surface of multiple lysine residues that starts at the bottom of the C1 domain and winds around the FVIII molecule.	Lysine	126-132	coagulation factor VIII	Homo sapiens	64-69
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Lysine	46-49	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	110-114
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Lysine	46-49	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	159-163
23632855-7	2013	EMF1 is required for trimethylating lysine-27 on histone 3 (H3K27me3), and ULT1 associates with ARABIDOPSIS TRITHORAX1 (ATX1) for trimethylating lysine-3 on histone 4 (H3K4me3) at flower MADS box gene loci.	Lysine	36-42	embryonic flower 1 (EMF1)	Arabidopsis thaliana	0-4
23632855-7	2013	EMF1 is required for trimethylating lysine-27 on histone 3 (H3K27me3), and ULT1 associates with ARABIDOPSIS TRITHORAX1 (ATX1) for trimethylating lysine-3 on histone 4 (H3K4me3) at flower MADS box gene loci.	Lysine	145-151	embryonic flower 1 (EMF1)	Arabidopsis thaliana	0-4
25903134-6	2015	Together with structural docking studies, our data suggest that FVIII interacts with LRP1 via an extended surface of multiple lysine residues that starts at the bottom of the C1 domain and winds around the FVIII molecule.	Lysine	126-132	coagulation factor VIII	Homo sapiens	206-211
25672609-1	2015	SUZ12 is a core component of the polycomb repressive complex 2 (PRC2), which could silence gene transcription by generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3).	Lysine	142-148	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	0-5
23416211-1	2013	The effects of a snake venom Lys-49 phospholipase A2 (PLA2) homolog named MT-II, devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2 (COX-2) and signaling pathways involved were evaluated in mouse macrophages in culture and in peritoneal cells ex vivo.	Lysine	29-32	prostaglandin-endoperoxide synthase 2	Mus musculus	175-191
23583077-3	2013	We have engineered the naturally occurring MBT domain repeats of L3MBTL1 to serve as a universal affinity reagent for detecting, enriching, and identifying proteins carrying a mono- or dimethylated lysine.	Lysine	198-204	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	65-72
19854152-1	2010	Yeast peroxisomal NADP(+)-specific isocitrate dehydrogenase (IDP3) contains a canonical type I peroxisomal targeting sequence (a carboxyl-terminal Cys-Lys-Leu tripeptide), and provides the NADPH required for beta-oxidation of some fatty acids in that organelle.	Lysine	151-154	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	61-65
20064247-0	2010	Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression.	Lysine	22-28	RELA proto-oncogene, NF-kB subunit	Homo sapiens	15-18
20064247-2	2010	We have earlier reported that p65, a subunit of NF-kappaB, is acetylated in vitro and in vivo at three different lysines (K310, K314 and K315) by the histone acetyltransferase p300.	Lysine	113-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	30-33
20064247-3	2010	RESULTS: In this study, we describe that site-specific mutation of p65 at lysines 314 and 315 enhances gene expression of a subset of NF-kappaB target genes including Mmp10 and Mmp13.	Lysine	74-81	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-70
20018689-3	2010	Here we report that heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z) and its partner, the H3 binding protein ESC, increase longevity and reduce adult levels of trimethylated H3K27 (H3K27me3).	Lysine	120-126	Polycomb	Drosophila melanogaster	67-75
26126716-3	2015	We showed that the serine-threonine kinase WNK1 [with no lysine (K)] forms a physical complex with KCC2 in the developing mouse brain.	Lysine	57-63	WNK lysine deficient protein kinase 1	Mus musculus	43-47
20006587-4	2010	Deletion of a short lysine-rich domain that contains the major SUMO acceptor sites of CBP abrogated its ability to be SUMO modified, and prevented its association with endogenous SUMO-1/PML speckles in vivo.	Lysine	20-26	small ubiquitin like modifier 1	Homo sapiens	179-185
23504328-6	2013	The mutation of four lysine residues on Rta that abrogated SUMO-3 conjugation to Rta also decreases the enhancement of the ubiquitination of Rta by RNF4.	Lysine	21-27	RNA binding fox-1 homolog 2	Homo sapiens	40-43
26115316-1	2015	The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively.	Lysine	110-116	valosin containing protein	Homo sapiens	51-54
23504328-6	2013	The mutation of four lysine residues on Rta that abrogated SUMO-3 conjugation to Rta also decreases the enhancement of the ubiquitination of Rta by RNF4.	Lysine	21-27	RNA binding fox-1 homolog 2	Homo sapiens	81-84
23504328-6	2013	The mutation of four lysine residues on Rta that abrogated SUMO-3 conjugation to Rta also decreases the enhancement of the ubiquitination of Rta by RNF4.	Lysine	21-27	RNA binding fox-1 homolog 2	Homo sapiens	81-84
19921743-6	2010	Especially effective in promoting the peptide binding is a Lys residue at the -5 position, a determinant present in both P2 (HPK1 394-403) and S1 (Shank2 1168-1189) peptides.	Lysine	59-62	SH3 and multiple ankyrin repeat domains 2	Mus musculus	147-153
26103639-5	2015	Recently, we showed that oral supplementation with Ps-1 as well as its related free amino acids (L-Arg and L-Lys) enhances PROP bitterness perception, especially for PROP non-tasters who have low salivary levels of Ps-1.	Lysine	107-112	taste 2 receptor member 62 pseudogene	Homo sapiens	51-55
20944394-3	2010	Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired.	Lysine	70-76	Vba2p	Saccharomyces cerevisiae S288C	19-23
23757933-0	2013	Effect of short peptides containing lysine and epsilon-aminocaproic acid on fibrinolytic activity of plasmin and topoisomerase II action on supercoiled DNA.	Lysine	36-42	plasminogen	Homo sapiens	101-108
26073453-5	2015	The method is generic and could be widely applied to study lysine PTMs.	Lysine	59-65	parathymosin	Homo sapiens	66-70
23457193-9	2013	In addition, we show that lysine 290 (K290) in Rtt109 is required in vivo for Vps75 to enhance the activity of the HAT.	Lysine	26-32	Vps75p	Saccharomyces cerevisiae S288C	78-83
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	lysine methyltransferase 2B	Homo sapiens	29-33
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	trithorax-related	Drosophila melanogaster	87-104
21502408-4	2010	PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response.	Lysine	57-63	lysine methyltransferase 5A	Homo sapiens	0-7
26046535-6	2015	Multiple gamma-secretase inhibitors (GSIs) and (Z-LL)2 ketone differentially inhibited SPP/SPPL activity; for example, IC50 of LY-411,575 varied from 51+-79 nM (on SPPL2a) to 5499+-122 nM (on SPPL2b), while Compound E showed inhibition only on hSPP with IC50 of 1465+-93 nM.	Lysine	127-129	histocompatibility minor 13	Homo sapiens	87-90
22553530-12	2010	Further analysis suggested the location of this carbamylation of alphaB-crystallin in the nucleus to be at Lys 92 and 103.	Lysine	107-110	crystallin alpha B	Bos taurus	65-82
23376100-1	2013	WNK1 [with no lysine (K)-1] is a 250-kDa serine/threonine protein kinase involved in the maintenance of cellular salt levels and is directly linked to a hereditary form of hypertension.	Lysine	14-20	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
23576758-6	2013	We show that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is required for full developmental silencing of mouse embryonic beta-like globin genes and human gamma-globin genes in adult erythroid cells in vivo.	Lysine	17-23	REST corepressor 2	Mus musculus	122-128
26046535-6	2015	Multiple gamma-secretase inhibitors (GSIs) and (Z-LL)2 ketone differentially inhibited SPP/SPPL activity; for example, IC50 of LY-411,575 varied from 51+-79 nM (on SPPL2a) to 5499+-122 nM (on SPPL2b), while Compound E showed inhibition only on hSPP with IC50 of 1465+-93 nM.	Lysine	127-129	signal peptide peptidase like 2A	Homo sapiens	164-170
23576758-6	2013	We show that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is required for full developmental silencing of mouse embryonic beta-like globin genes and human gamma-globin genes in adult erythroid cells in vivo.	Lysine	17-23	B cell CLL/lymphoma 11A (zinc finger protein)	Mus musculus	173-179
19889771-5	2010	Mapping data showed that multiple lysine residues are SUMO1 acceptors within S-HDAg.	Lysine	34-40	small ubiquitin like modifier 1	Homo sapiens	54-59
25736378-2	2015	Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation of senescence-associated beta-gal (SA-beta-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3).	Lysine	233-239	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	50-54
19934257-4	2010	SIRT1 deacetylates APE1 in vitro and in vivo targeting lysines 6 and 7.	Lysine	55-62	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	19-23
19934257-5	2010	Genotoxic insults stimulate lysine acetylation of APE1 which is antagonized by transcriptional upregulation of SIRT1.	Lysine	28-34	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	50-54
23514740-6	2013	Moreover, LAT was ubiquitinated at Lys(88) by TRAF6 via K63-linked chain.	Lysine	35-38	linker for activation of T cells	Homo sapiens	10-13
25495676-13	2015	It is concluded that dietary lysine to energy ratios of 0.672, 0.646, 0.639 and 0.649 optimized feed intake, growth rate, FCR and live weight in indigenous female Venda chickens fed diets containing 8 g of lysine/kg DM, 150 g of CP/kg DM and 11 MJ of ME/kg DM.	Lysine	29-35	FCR	Gallus gallus	122-125
23463508-5	2013	Modelization of a CD40 dimer allowed the identification of lysine 29 in CRD1, whose mutation decreased CD40 self-interaction without affecting expression or response to ligand.	Lysine	59-65	CD40 molecule	Homo sapiens	18-22
23463508-5	2013	Modelization of a CD40 dimer allowed the identification of lysine 29 in CRD1, whose mutation decreased CD40 self-interaction without affecting expression or response to ligand.	Lysine	59-65	CD40 molecule	Homo sapiens	103-107
23416615-3	2013	Monoubiquitinated MALT1 had enhanced protease activity, whereas a ubiquitination-deficient MALT1 mutant with replacement of that lysine with arginine (MALT1(K644R)) had less protease activity, which correlated with impaired induction of interleukin 2 (IL-2) via the T cell antigen receptor in activated T cells.	Lysine	129-135	MALT1 paracaspase	Homo sapiens	91-96
23416615-3	2013	Monoubiquitinated MALT1 had enhanced protease activity, whereas a ubiquitination-deficient MALT1 mutant with replacement of that lysine with arginine (MALT1(K644R)) had less protease activity, which correlated with impaired induction of interleukin 2 (IL-2) via the T cell antigen receptor in activated T cells.	Lysine	129-135	MALT1 paracaspase	Homo sapiens	91-96
19799950-3	2010	The peptide, termed SK84 due to its N-terminal serine, C-terminal lysine and a total of 84 residues, was completed sequenced using RT-PCR cDNA cloning.	Lysine	66-72	ATPase inhibitor A, mitochondrial	Drosophila virilis	20-24
20086187-4	2010	The nuclear-enriched RAD23 proteins bind Ub conjugates, especially those linked internally through Lys-48, via their UBA domains, and associate with the 26S proteasome Ub receptor RPN10 via their N-terminal UBL domains.	Lysine	99-102	Rad23 UV excision repair protein family	Arabidopsis thaliana	21-26
25855754-3	2015	We demonstrated that SetD8, a histone methyltransferase that catalyzes monomethylation of histone H4 at lysine 20 (H4K20me1), is a context-dependent GATA-1 corepressor in erythroid cells.	Lysine	104-110	GATA binding protein 1	Mus musculus	149-155
19927120-1	2009	TAB2 and TAB3 activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain.	Lysine	120-123	NPL4 homolog, ubiquitin recognition factor	Homo sapiens	162-166
25933497-5	2015	Moreover, compared with the livers of control rats, levels of mono-methylated histone H3 lysine (K) 4 and acetylated histone H4 were higher in the promoter/enhancer region of the Fasn gene in the livers of SHR/NDmc-cp rats.	Lysine	89-95	fatty acid synthase	Rattus norvegicus	179-183
20003470-2	2009	It is catalyzed by a specific enzymatic cascade ultimately leading to the conjugation of ubiquitin to lysine residues of the target protein that can be the ubiquitin molecule itself and to the formation of poly-ubiquitin chains.	Lysine	102-108	ubiquitin	Bos taurus	89-98
20003470-2	2009	It is catalyzed by a specific enzymatic cascade ultimately leading to the conjugation of ubiquitin to lysine residues of the target protein that can be the ubiquitin molecule itself and to the formation of poly-ubiquitin chains.	Lysine	102-108	ubiquitin	Bos taurus	156-165
20003470-2	2009	It is catalyzed by a specific enzymatic cascade ultimately leading to the conjugation of ubiquitin to lysine residues of the target protein that can be the ubiquitin molecule itself and to the formation of poly-ubiquitin chains.	Lysine	102-108	ubiquitin	Bos taurus	156-165
20003470-8	2009	This arrangement of ubiquitin could illustrate how linkages involving Lys-6 or Lys-63 of ubiquitin are produced in the cell.	Lysine	70-73	ubiquitin	Bos taurus	20-29
20003470-8	2009	This arrangement of ubiquitin could illustrate how linkages involving Lys-6 or Lys-63 of ubiquitin are produced in the cell.	Lysine	70-73	ubiquitin	Bos taurus	89-98
20003470-8	2009	This arrangement of ubiquitin could illustrate how linkages involving Lys-6 or Lys-63 of ubiquitin are produced in the cell.	Lysine	79-82	ubiquitin	Bos taurus	20-29
23280602-4	2013	PRDM14 binds to silenced genes in human ESCs and its global binding profile is enriched for the repressive trimethylation of histone H3 lysine 27 (H3K27me3) modification.	Lysine	136-142	PR/SET domain 14	Homo sapiens	0-6
23389250-4	2013	Two natural variants of APC [Arg-147 to Trp substitution (R147W) and Lys-150 deletion (K150del)] have been identified in the Chinese population as hotspot mutants occurring with high frequencies of 27.8% and 13.9%, respectively, among 36 protein C-deficient subjects.	Lysine	69-72	APC regulator of WNT signaling pathway	Homo sapiens	24-27
20003470-8	2009	This arrangement of ubiquitin could illustrate how linkages involving Lys-6 or Lys-63 of ubiquitin are produced in the cell.	Lysine	79-82	ubiquitin	Bos taurus	89-98
23454124-2	2013	Emerging evidence shows that transient hyperglycemic exposure of human endothelial cells induces histone 3 lysine 4 mono-methylation (H3K4me1) on the promoter and persistent mRNA expression of RelA and IL-8 genes, suggesting that epigenetic histone modification and chromatin structure remodeling is a key event underlying metabolic memory.	Lysine	107-113	RELA proto-oncogene, NF-kB subunit	Homo sapiens	193-197
26010904-6	2015	Proteomic analysis by mass spectrometry revealed that only 12 of 39 detectable lysine residues were ubiquitinated by UbcH5a in Hsp70 and only 16 of 45 in Hsc70.	Lysine	79-85	ubiquitin conjugating enzyme E2 D1	Homo sapiens	117-123
23507839-5	2013	Suz12 is essential for the Polycomb Repressive Complex 2 (PRC2) mediating the repressive trimethylation of H3 on lysine-27 (H3K27me3).	Lysine	113-119	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	0-5
25909289-1	2015	JARID1B is a member of the family of JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4).	Lysine	114-120	lysine demethylase 5B	Homo sapiens	0-7
23319570-4	2013	Many of the promoter-distal IRF8 binding sites show an increase in histone H3 lysine 4 monomethylation, a signature for enhancers.	Lysine	78-84	interferon regulatory factor 8	Mus musculus	28-32
19732783-4	2009	Yeast Sas2p is orthologous to human MYST1, a histone 4 lysine 16 (H4K16) acetyltransferase.	Lysine	55-61	lysine acetyltransferase 8	Homo sapiens	36-41
19955385-9	2009	Blocking ER with ICI 182,780 or mGluR1a with LY 367385 prevented ERalpha trafficking to and from the membrane.	Lysine	45-47	glutamate metabotropic receptor 1	Homo sapiens	32-38
25909289-1	2015	JARID1B is a member of the family of JmjC domain-containing proteins that removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4).	Lysine	137-143	lysine demethylase 5B	Homo sapiens	0-7
25938837-8	2015	Using exome-sequencing analysis, a possibly damaging, non-synonymous variant in the gene Nebulin (NEB) was found to segregate with PACG which alters a phylogenetically conserved Lysine residue.	Lysine	178-184	nebulin	Homo sapiens	89-96
19807846-7	2009	The mGluR1a antagonist, LY 367385 (20 nm), blocked the oxytocin (1 nm)-induced [Ca(2+)](i) flux (DeltaF Ca(2+) = 344 +/- 19 versus 127 +/- 11 RFU, P &lt; 0.001).	Lysine	24-26	glutamate metabotropic receptor 1	Homo sapiens	4-10
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	interleukin 1 receptor associated kinase 1	Homo sapiens	48-53
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	MYD88 innate immune signal transduction adaptor	Homo sapiens	60-65
25903303-1	2015	Histone methyltransferase PRDM9 catalyzes the methylation of H3K4me2 (histone 3 dimethylated lysine 4) to H3K4me3 (histone 3 trimethylated lysine 4) by transferring the methyl group from S-adenosyl methionine (AdoMet).	Lysine	93-99	PR/SET domain 9	Homo sapiens	26-31
23175442-1	2013	Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating transcription.	Lysine	131-137	euchromatic histone methyltransferase 1	Mus musculus	0-39
23175442-1	2013	Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating transcription.	Lysine	131-137	euchromatic histone methyltransferase 1	Mus musculus	41-46
19892738-4	2009	In N-CLAP, simple and readily available reagents are used to selectively affinity label the alpha-amine that characterizes the protein N terminus over the more highly abundant epsilon-amine on lysine residues.	Lysine	193-199	BCL10 immune signaling adaptor	Homo sapiens	5-9
19864627-0	2009	Regulation of NF-kappaB activity through lysine monomethylation of p65.	Lysine	41-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-70
19864627-4	2009	Set9 specifically methylates p65 at lysine 37.	Lysine	36-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-32
25903303-1	2015	Histone methyltransferase PRDM9 catalyzes the methylation of H3K4me2 (histone 3 dimethylated lysine 4) to H3K4me3 (histone 3 trimethylated lysine 4) by transferring the methyl group from S-adenosyl methionine (AdoMet).	Lysine	139-145	PR/SET domain 9	Homo sapiens	26-31
25903303-3	2015	In PRDM9, two conserved tyrosine residues Tyr357 and Tyr276 surrounding the amino group of the substrate lysine may influence the methylation activity through hydrogen bond interactions with AdoMet or the substrate lysine.	Lysine	105-111	PR/SET domain 9	Homo sapiens	3-8
25903303-3	2015	In PRDM9, two conserved tyrosine residues Tyr357 and Tyr276 surrounding the amino group of the substrate lysine may influence the methylation activity through hydrogen bond interactions with AdoMet or the substrate lysine.	Lysine	215-221	PR/SET domain 9	Homo sapiens	3-8
19660582-4	2009	Research in yeast further indicates that the ortholog of Sug1, Rpt6, is a link between ubiquitination of histone H2B and H3 lysine 4 trimethylation (H3K4me3).	Lysine	124-130	proteasome regulatory particle base subunit RPT6	Saccharomyces cerevisiae S288C	57-61
26018265-1	2015	OBJECTIVE: To investigate the mechanism of high transcription of the glial cell-line derived neurotrophic factor (gdnf) gene induced by hyperacetylation of histone H3 lysine 9 (H3K9) at its promoter region II in rat C6 glioma cells.	Lysine	167-173	glial cell derived neurotrophic factor	Rattus norvegicus	69-112
19660582-4	2009	Research in yeast further indicates that the ortholog of Sug1, Rpt6, is a link between ubiquitination of histone H2B and H3 lysine 4 trimethylation (H3K4me3).	Lysine	124-130	proteasome regulatory particle base subunit RPT6	Saccharomyces cerevisiae S288C	63-67
23300075-10	2013	Indeed, in cells with endogenous MARCH expression, TRAIL-R1 was ubiquitinated at steady-state, with the conserved membrane-proximal lysine 273 as one of the potential acceptor sites.	Lysine	132-138	TNF receptor superfamily member 10a	Homo sapiens	51-59
19670252-2	2009	Because of its high specificity towards the amino acid sequence (Asp)(4)-Lys, enterokinase is a potential tool for the cleavage of fusion proteins, which are gaining more importance in biopharmaceutical production.	Lysine	73-76	transmembrane serine protease 15	Bos taurus	78-90
26018265-1	2015	OBJECTIVE: To investigate the mechanism of high transcription of the glial cell-line derived neurotrophic factor (gdnf) gene induced by hyperacetylation of histone H3 lysine 9 (H3K9) at its promoter region II in rat C6 glioma cells.	Lysine	167-173	glial cell derived neurotrophic factor	Rattus norvegicus	114-118
25800736-4	2015	We identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348 (K348).	Lysine	69-75	lysine acetyltransferase 2B	Homo sapiens	19-23
20099524-0	2009	Short peptides containing L-lysine and epsilon-aminocaproic acid as potential plasmin inhibitors.	Lysine	26-34	plasminogen	Homo sapiens	78-85
20099524-1	2009	Eight short peptides containing L-lysine and epsilon-aminocaproic acid were obtained and their effect on the amidolytic activities of plasmin, thrombin and trypsin was examined.	Lysine	32-40	plasminogen	Homo sapiens	134-141
19825828-4	2009	Through the use of the Ubc13-Uev1A E2 complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling.	Lysine	65-71	actin related gene 1	Mus musculus	47-51
23297398-8	2013	Consistent with a functional role for deubiquitination, mutation of the cytoplasmic lysines of ENaC reduced the effect of USP8 on ENaC cell surface abundance.	Lysine	84-91	ubiquitin specific peptidase 8	Homo sapiens	122-126
19825828-6	2009	We also showed that the lysine-124 residue of TRAF6 was critical for efficient Act1-mediated ubiquitination of TRAF6 and for the ability of TRAF6 to mediate IL-17-induced activation of nuclear factor kappaB.	Lysine	24-30	actin related gene 1	Mus musculus	79-83
22899583-8	2013	In addition, suppressive trimethylation of histone H3 lysine 27 of important T-cell transcription factor genes (GATA3, LEF1, TCF1) was present in anaplastic large cell lymphoma cells, which is in line with their absence in primary tumor specimens as demonstrated by immunohistochemistry.	Lysine	54-60	lymphoid enhancer binding factor 1	Homo sapiens	119-123
25796185-2	2015	Herein, we describe the identification and characterization of a CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) ubiquitin-binding domain (UBD) in PS1, and demonstrate that the CUE domain of PS1 mediates non-covalent binding to Lysine 63-linked polyubiquitin chains.	Lysine	257-263	presenilin 1	Homo sapiens	176-179
23212909-7	2013	Mutation of seven lysines at the C-terminal region of Arkadia severely impairs ubiquitination through the K27 but not the K63 linkage and slows down the turnover of Arkadia, suggesting that K27-linked polyubiquitination might promote proteolysis-dependent regulation of Arkadia.	Lysine	18-25	keratin 27	Homo sapiens	106-109
19668227-9	2009	Microtubule association, and paclitaxel sensitivity, depends on a critical lysine (K156) within a microtubule-binding motif (KLD) in DED-b of caspase 8.	Lysine	75-81	caspase 8	Homo sapiens	142-151
25796185-2	2015	Herein, we describe the identification and characterization of a CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) ubiquitin-binding domain (UBD) in PS1, and demonstrate that the CUE domain of PS1 mediates non-covalent binding to Lysine 63-linked polyubiquitin chains.	Lysine	257-263	presenilin 1	Homo sapiens	220-223
25716317-6	2015	Here, we demonstrated that the TRAF2-TRIP interaction inhibits Lys(63)-linked TRAF2 ubiquitination by inhibiting TRAF2 E3 ubiquitin (Ub) ligase activity.	Lysine	63-66	TRAF interacting protein	Homo sapiens	37-41
19818714-0	2009	BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.	Lysine	37-43	deltex E3 ubiquitin ligase 3L	Homo sapiens	0-4
19818714-3	2009	Herein, we demonstrate that BBAP selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents.	Lysine	74-80	deltex E3 ubiquitin ligase 3L	Homo sapiens	28-32
23110939-7	2013	Trimethylated histone H3 lysine 9 underwent demethylation and subsequent acetylation specifically in the region of the OAS1 promoter.	Lysine	25-31	2'-5'-oligoadenylate synthetase 1	Homo sapiens	119-123
25855960-3	2015	Here, we show that PCAF can directly acetylate cytoplasmic GLI1 protein at lysine 518, preventing its nuclear translocation and promoter occupancy, and consequently suppressing Hedgehog (Hh) signaling in HCC.	Lysine	75-81	lysine acetyltransferase 2B	Homo sapiens	19-23
23192343-8	2013	Expression studies of missense mutations identified in mucolipidosis III patients that alter amino acids in the N- and C-terminal domains demonstrated that the substitution of a lysine residue in close proximity to the dileucine sorting motif impaired ER-Golgi transport and subsequent activation of the PT alpha/beta-subunit precursor protein.	Lysine	178-184	pre T cell antigen receptor alpha	Homo sapiens	304-312
23359867-4	2013	Lysine 591 of menin was covalently modified by SUMO1 and K591R mutation in menin blocked SUMOylation of the C-terminal part of menin in transfected cells.	Lysine	0-6	small ubiquitin like modifier 1	Homo sapiens	47-52
19752231-8	2009	A central pocket binds arginine 83, the only Bw4 motif residue essential for KIR3DL1 interaction, similar to the binding of lysine 80 in HLA-C by KIR2DL1.	Lysine	124-130	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	Mus musculus	77-84
19564335-6	2009	Using chromatin immunoprecipitation we show that the eIF2alpha-dependent translationally regulated gene ATF4 binds directly to the CA9 promoter and is associated with loss of the transcriptional repressive histone 3 lysine 27 tri-methylation mark.	Lysine	216-222	eukaryotic translation initiation factor 2A	Mus musculus	53-62
19564335-6	2009	Using chromatin immunoprecipitation we show that the eIF2alpha-dependent translationally regulated gene ATF4 binds directly to the CA9 promoter and is associated with loss of the transcriptional repressive histone 3 lysine 27 tri-methylation mark.	Lysine	216-222	carbonic anhydrase 9	Mus musculus	131-134
25466885-3	2015	We hypothesized that IUGR disrupts the normal developmental maturation of hepatic IGF-1 intron 2 growth hormone response element (IN2GHRE) histone methylation of key lysines and DNA methylation.	Lysine	166-173	gonadotropin releasing hormone receptor	Rattus norvegicus	97-111
19651644-3	2009	To address this question, we first showed that the lysine 4 residue of histone H3 is substantially methylated at Egamma1 and Egamma4 elements in wild-type early thymocytes and that the levels of the methylation are reduced in IL-7R alpha chain-deficient mice.	Lysine	51-57	interleukin 7 receptor	Mus musculus	226-237
25594381-0	2015	Protein lysine acetylation by p300/CBP.	Lysine	8-14	E1A binding protein p300	Homo sapiens	30-34
19553338-3	2009	During infections with viral mutants containing lysine substitutions or the methylation inhibitor adenosine dialdehyde, the interaction of ICP27 with SRPK1 and Aly/REF was decreased, as determined by coimmunoprecipitation and colocalization studies, indicating that ICP27 RGG box methylation regulates interaction with these proteins.	Lysine	48-54	SRSF protein kinase 1	Homo sapiens	150-155
24009852-6	2013	Enhanced catabolism of cellular polyamines by polyamine oxidases (PAO), spermine oxidase (SMO) or acetylpolyamine oxidase (AcPAO), increases cellular oxidative stress and generates hydrogen peroxide and a reactive toxic metabolite, acrolein, which covalently incorporates into lysine residues of cellular proteins.	Lysine	277-283	spermine oxidase	Homo sapiens	72-88
24009852-6	2013	Enhanced catabolism of cellular polyamines by polyamine oxidases (PAO), spermine oxidase (SMO) or acetylpolyamine oxidase (AcPAO), increases cellular oxidative stress and generates hydrogen peroxide and a reactive toxic metabolite, acrolein, which covalently incorporates into lysine residues of cellular proteins.	Lysine	277-283	spermine oxidase	Homo sapiens	90-93
25689450-6	2015	The C4K12 protein polymer consists of a positively charged binding block (12 lysines, K12) and a hydrophilic random coil block of 400 amino acids (C4).	Lysine	77-84	keratin 12	Homo sapiens	6-9
23215760-0	2013	Incidence of the Hb E [beta26(B8)Glu Lys, GAG&gt;AAG] variant in Totos, one of the smallest primitive tribes in the world.	Lysine	37-40	hemoglobin subunit epsilon 1	Homo sapiens	17-21
19581289-8	2009	Either suppression of p300 by siRNA or mutation of acetylatable lysine residues of NPM1 resulted in reduced occupancy of acetylated NPM1 on the target gene promoter concomitant with its decreased transcript levels.	Lysine	64-70	nucleophosmin 1	Homo sapiens	83-87
19581289-8	2009	Either suppression of p300 by siRNA or mutation of acetylatable lysine residues of NPM1 resulted in reduced occupancy of acetylated NPM1 on the target gene promoter concomitant with its decreased transcript levels.	Lysine	64-70	nucleophosmin 1	Homo sapiens	132-136
19581291-5	2009	Canonical bromodomains can bind to acetylated lysines on histones; however, the Yta7 bromodomain showed an association with histones that was independent of posttranslational modification.	Lysine	46-53	Yta7p	Saccharomyces cerevisiae S288C	80-84
23806116-0	2013	Hb Papanui [alpha99(G8)Lys Arg; HBA2: c.299A&gt;G]: a novel silent substitution interfering in Hb A1c determination.	Lysine	23-26	hemoglobin subunit alpha 2	Homo sapiens	32-36
25766875-3	2015	Here we show that the corepressor Tup1 is sumoylated, at two specific lysines, under various stress conditions.	Lysine	70-77	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	34-38
19536136-8	2009	Further, we show that the Epsin1 tandem UIM, which has an inter-UIM region similar to that of RAP80-UIM1-UIM2, also selectively binds Lys 63-linked di-ubiquitin.	Lysine	134-137	epsin 1	Homo sapiens	26-32
25636230-2	2015	We optimized the method of identification of lysine residues prone to glycation using the combination of LC-MS, isotopic labeling, and modified synthetic peptide standards with the glycated lysine derivative (Fmoc-Lys(i,i-Fru,Boc)-OH).	Lysine	45-51	zinc finger and BTB domain containing 22	Homo sapiens	222-225
19453968-2	2009	The suppressor of cytokine signaling protein SOCS3 drives lysosomal degradation of the granulocyte colony-stimulating factor receptor (G-CSFR), depending on SOCS3-mediated ubiquitination of a specific lysine located in a conserved juxtamembrane motif.	Lysine	201-207	suppressor of cytokine signaling 3	Homo sapiens	45-50
19453968-2	2009	The suppressor of cytokine signaling protein SOCS3 drives lysosomal degradation of the granulocyte colony-stimulating factor receptor (G-CSFR), depending on SOCS3-mediated ubiquitination of a specific lysine located in a conserved juxtamembrane motif.	Lysine	201-207	suppressor of cytokine signaling 3	Homo sapiens	157-162
19453968-5	2009	However, within this region, the lysine could be shifted 12 amino acids toward the C-terminus without losing its function, arguing against the existence of a linear sorting motif and demonstrating that positioning of the lysine relative to the SOCS3 docking site is flexible.	Lysine	33-39	suppressor of cytokine signaling 3	Homo sapiens	244-249
19483727-2	2009	Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112.	Lysine	126-133	lysine acetyltransferase 2B	Homo sapiens	25-48
23048139-1	2013	The primary pathway of lysine degradation in pigs presumably depends on the bifunctional protein alpha-aminoadipate delta-semialdehyde synthase (AASS), which contains lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH) activities.	Lysine	23-29	aminoadipate-semialdehyde synthase	Sus scrofa	97-143
23048139-1	2013	The primary pathway of lysine degradation in pigs presumably depends on the bifunctional protein alpha-aminoadipate delta-semialdehyde synthase (AASS), which contains lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH) activities.	Lysine	23-29	aminoadipate-semialdehyde synthase	Sus scrofa	145-149
23048139-2	2013	In liver, AASS is restricted to the mitochondrial matrix and lysine is presumptively transported through the plasma membrane by a cationic AA transporter (CAT1/2) and through the inner mitochondrial membrane by 1 or both mitochondrial ornithine transporters (ORC-1/ORC-2).	Lysine	61-67	solute carrier family 7 member 1	Sus scrofa	155-161
25236368-1	2015	Small ubiquitin-like modifier (SUMO1-3) conjugation is a posttranslational protein modification whereby SUMOs are conjugated to lysine residues of target proteins.	Lysine	128-134	small ubiquitin like modifier 1	Homo sapiens	31-38
23516328-6	2013	Recent findings reveal that Eco1-mediated acetylation of different lysine residues in Smc3 during S phase promote either cohesion or condensation.	Lysine	67-73	structural maintenance of chromosomes 3	Homo sapiens	86-90
23797602-5	2013	This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.	Lysine	77-83	PHD finger protein 20	Homo sapiens	56-61
23797602-5	2013	This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.	Lysine	77-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	96-99
23797602-5	2013	This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.	Lysine	77-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-141
19362556-6	2009	However, the overall homology of GnRH-I precursor polypeptide (including a 23 amino acid signal peptide, the decapeptide hormone and Gly-Lys-Arg cleavage site followed by 55 amino acid GnRH-associated peptide sequences) between starling and chicken was only 58%.	Lysine	137-140	LOW QUALITY PROTEIN: progonadoliberin-1	Sturnus vulgaris	33-39
19564914-7	2009	Such treatment increased H4 acetylation and H3 lysine 4 methylation at the promoters of Hoxb1 and Hoxb9, but not the promoters of Pou5f1, Nanog,Cdx2 or the housekeeping gene Gapdh.	Lysine	47-53	homeobox B1	Mus musculus	88-93
25628365-3	2015	The structurally disordered N-terminal tail of DDB2 contains seven lysines identified as major sites for ubiquitination that target the protein for proteasomal degradation; however, the precise biological functions of these modifications remained unknown.	Lysine	67-74	damage specific DNA binding protein 2	Homo sapiens	47-51
19397897-6	2009	A mutant ubiquitin, with Lys6 replaced by Arg, completely lost activity, whereas a mutant, with six other Lys residues (positions at 11, 27, 29, 33, 48 and 63) substituted by Arg, retained activity.	Lysine	25-28	ubiquitin	Saccharomyces cerevisiae S288C	9-18
23797602-5	2013	This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.	Lysine	77-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-141
25569455-4	2015	Herein we demonstrate that p30(II) induces lysine-acetylation of the c-MYC oncoprotein.	Lysine	43-49	centromere protein V	Homo sapiens	27-30
23237831-5	2013	By using mouse N-terminally tagged streptavidin-binding peptide-hemagglutinin-TANK-binding kinase 1 (SH-TBK1), we chemically cross-linked the affinity-purified complex of SH-TBK1 with the homobifunctional lysine-specific reagent bis(sulfosuccinimidyl) suberate (BS(3)), and we separated the resultant protein complexes by denaturation and by silver-stained one- and two-dimensional SDS-PAGE.	Lysine	205-211	TANK-binding kinase 1	Mus musculus	104-108
23237831-5	2013	By using mouse N-terminally tagged streptavidin-binding peptide-hemagglutinin-TANK-binding kinase 1 (SH-TBK1), we chemically cross-linked the affinity-purified complex of SH-TBK1 with the homobifunctional lysine-specific reagent bis(sulfosuccinimidyl) suberate (BS(3)), and we separated the resultant protein complexes by denaturation and by silver-stained one- and two-dimensional SDS-PAGE.	Lysine	205-211	TANK-binding kinase 1	Mus musculus	174-178
19332550-0	2009	Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.	Lysine	99-102	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	64-69
19332550-0	2009	Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.	Lysine	99-102	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	70-74
19351806-9	2009	Visfatin increased total Akt and Ser(473)-phospho-Akt expression with concomitant rises in eNOS phosphorylation at Ser(1177); these effects were blocked by LY-2940002.	Lysine	156-158	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
23536830-5	2013	NF-kappaB p65 Lys(310) acetylation and Ser(276) phosphorylation were detected in co-transfection experiments with NF-kappaB p65 and ORFV002 or its mutants with, or without, the N-terminal region.	Lysine	14-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	10-13
25564762-0	2015	A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.	Lysine	2-8	Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein	Caenorhabditis elegans	55-60
23536830-5	2013	NF-kappaB p65 Lys(310) acetylation and Ser(276) phosphorylation were detected in co-transfection experiments with NF-kappaB p65 and ORFV002 or its mutants with, or without, the N-terminal region.	Lysine	14-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-13
23405236-4	2013	The lysine residue at position 51 (K51) of hGBP1 was essential for inhibition of IAV replication.	Lysine	4-10	guanylate binding protein 1	Homo sapiens	43-48
19618839-9	2009	These five loci (and the two loci which had significant effect on blood EtOH in ALDH2 Glu/Glu and Glu/Lys subjects) also showed strong linkage disequilibrium.	Lysine	102-105	aldehyde dehydrogenase 2 family member	Homo sapiens	80-85
25564762-4	2015	Here we report that a lysine-rich motif in the extracellular domain of PSR-1, the Caenorhabditis elegans PSR, mediates specific phosphatidylserine binding in vitro and clearance of apoptotic cells in vivo.	Lysine	22-28	Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein	Caenorhabditis elegans	71-76
19484123-8	2009	The Lys 154, 164, and 172 residues of the RIG-I CARD domain were critical for efficient REUL-mediated ubiquitination, as well as the ability of RIG-I to induce activation of IFN-beta promoter.	Lysine	4-7	interferon beta 1	Homo sapiens	174-182
25359864-9	2015	Chromatin immunoprecipitation assays showed a significant decrease in trimethylated histone H3 lysine 9 occupancy at the glucose-regulated protein-78 and CEBP-homologous protein promoters in mice treated with adenosine dialdehyde and SAH hydrolase short hairpin RNA when compared with control mice.	Lysine	95-101	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	154-158
23437158-2	2013	In Drosophila, cis-regulatory regions termed PcG response elements (PREs) act as nucleation sites for PcG proteins to create large repressive PcG domains that are marked by trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	191-197	Polycomb	Drosophila melanogaster	45-48
23437158-2	2013	In Drosophila, cis-regulatory regions termed PcG response elements (PREs) act as nucleation sites for PcG proteins to create large repressive PcG domains that are marked by trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	191-197	Polycomb	Drosophila melanogaster	102-105
23437158-2	2013	In Drosophila, cis-regulatory regions termed PcG response elements (PREs) act as nucleation sites for PcG proteins to create large repressive PcG domains that are marked by trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	191-197	Polycomb	Drosophila melanogaster	102-105
19286653-6	2009	We determined, for the first time, that the epigenetic control leading to the transcriptional silencing of both MMPs includes hypermethylation of the corresponding CpG regions and histone H3 lysine-27 trimethylation (H3K27me3).	Lysine	191-197	matrix metallopeptidase 2	Homo sapiens	112-116
25923537-2	2015	The Tudor domains of human homologs PHF1 and PHF19 have been found to recognize trimethylated lysine 36 of histone H3 (H3K36me3); however, the biological role of Tudor domains of other Pcl proteins remains poorly understood.	Lysine	94-100	PHD finger protein 19	Homo sapiens	45-50
19286653-7	2009	In turn, undermethylation of the CpG islands and low levels of histone H3 lysine-27 trimethylation are features of transcriptionally active MT1-MMP and MMP-2 genes in invasive cancer cells.	Lysine	74-80	matrix metallopeptidase 14	Homo sapiens	140-147
19286653-7	2009	In turn, undermethylation of the CpG islands and low levels of histone H3 lysine-27 trimethylation are features of transcriptionally active MT1-MMP and MMP-2 genes in invasive cancer cells.	Lysine	74-80	matrix metallopeptidase 2	Homo sapiens	152-157
19376117-3	2009	Interestingly, the ubiquitinations and degradations of BCL2L12 and BCL2L12A are independent of the internal lysine residues but the first N-terminal residues.	Lysine	108-114	BCL2 like 12	Homo sapiens	55-62
23382880-4	2013	Here we identified that the major SUMO-1 binding site was located on lysine 166.	Lysine	69-75	small ubiquitin like modifier 1	Homo sapiens	34-40
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	tripartite motif containing 25	Homo sapiens	282-288
19376117-3	2009	Interestingly, the ubiquitinations and degradations of BCL2L12 and BCL2L12A are independent of the internal lysine residues but the first N-terminal residues.	Lysine	108-114	BCL2 like 12	Homo sapiens	67-74
25452809-4	2015	PAR-2 mRNA was significantly upregulated in the cells treated with trypsin or the PAR-2 activating peptide Ser-Leu-Ile-Gly-Lys-Val (SLIGKV) (P&lt;0.01), but not in the Val-Lys-Gly-Ile-Leu-Ser group (P&gt;0.05).	Lysine	123-126	F2R like trypsin receptor 1	Homo sapiens	0-5
19272411-2	2009	We have previously shown that mutation of a catalytic lysine in the plasmodial Pdx1 protein results in a protein that is both inactive and hexameric in vitro.	Lysine	54-60	pancreatic and duodenal homeobox 1	Homo sapiens	79-83
25452809-4	2015	PAR-2 mRNA was significantly upregulated in the cells treated with trypsin or the PAR-2 activating peptide Ser-Leu-Ile-Gly-Lys-Val (SLIGKV) (P&lt;0.01), but not in the Val-Lys-Gly-Ile-Leu-Ser group (P&gt;0.05).	Lysine	123-126	F2R like trypsin receptor 1	Homo sapiens	82-87
25452809-4	2015	PAR-2 mRNA was significantly upregulated in the cells treated with trypsin or the PAR-2 activating peptide Ser-Leu-Ile-Gly-Lys-Val (SLIGKV) (P&lt;0.01), but not in the Val-Lys-Gly-Ile-Leu-Ser group (P&gt;0.05).	Lysine	172-175	F2R like trypsin receptor 1	Homo sapiens	0-5
23249737-1	2012	Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation.	Lysine	107-110	lysine methyltransferase 2B	Homo sapiens	0-24
25452809-4	2015	PAR-2 mRNA was significantly upregulated in the cells treated with trypsin or the PAR-2 activating peptide Ser-Leu-Ile-Gly-Lys-Val (SLIGKV) (P&lt;0.01), but not in the Val-Lys-Gly-Ile-Leu-Ser group (P&gt;0.05).	Lysine	172-175	F2R like trypsin receptor 1	Homo sapiens	82-87
23249737-1	2012	Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation.	Lysine	107-110	lysine methyltransferase 2B	Homo sapiens	26-30
23407807-2	2009	It is a non-protease plasminogen activator that activates plasminogen to plasmin, the enzyme that degrades fibrin cloth through its specific lysine binding site; it is used therefore as a drug in thrombolytic therapy.	Lysine	141-147	plasminogen	Homo sapiens	21-28
23249737-1	2012	Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation.	Lysine	107-110	lysine methyltransferase 2B	Homo sapiens	44-48
25452565-9	2015	Decreased SIRT1 expression was associated with constitutively enhanced expression of the transcriptionally active form of the p65 (acetylated on lysine 310) subunit of NF-kappaB exclusively in the LPL compartment.	Lysine	145-151	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
23109339-7	2012	Mutational analysis of the lysines in the calmodulin-binding site revealed that Lys-739 is a major site for poly-ubiquitination of nNOS in vitro and regulates, in large part, the CHIP-dependent degradation of nNOS in HEK293 cells, as well as in in vitro studies with fraction II.	Lysine	27-34	nitric oxide synthase 1	Homo sapiens	131-135
23109339-7	2012	Mutational analysis of the lysines in the calmodulin-binding site revealed that Lys-739 is a major site for poly-ubiquitination of nNOS in vitro and regulates, in large part, the CHIP-dependent degradation of nNOS in HEK293 cells, as well as in in vitro studies with fraction II.	Lysine	80-83	nitric oxide synthase 1	Homo sapiens	131-135
23109339-7	2012	Mutational analysis of the lysines in the calmodulin-binding site revealed that Lys-739 is a major site for poly-ubiquitination of nNOS in vitro and regulates, in large part, the CHIP-dependent degradation of nNOS in HEK293 cells, as well as in in vitro studies with fraction II.	Lysine	80-83	nitric oxide synthase 1	Homo sapiens	209-213
25452565-12	2015	Our results point to a possible mechanism where the normal immunosuppressive function of SIRT1 is inhibited by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).	Lysine	195-201	microRNA 34a	Homo sapiens	120-127
19067653-5	2009	A mutational analysis reveals that ERRgamma2 activity is modulated through sumoylation of a lysine residue at position 40, which in turn is regulated by phosphorylation.	Lysine	92-98	estrogen related receptor gamma	Homo sapiens	35-44
25452565-12	2015	Our results point to a possible mechanism where the normal immunosuppressive function of SIRT1 is inhibited by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).	Lysine	195-201	RELA proto-oncogene, NF-kB subunit	Homo sapiens	190-193
25320310-9	2015	Here, we demonstrate for the first time that ubiquitin and SUMO compete for the same lysine (K242) on M1 and the interaction of NS2 with AIMP2 facilitates the switch of the M1 modification from ubiquitination to SUMOylation, thus increasing viral replication.	Lysine	85-91	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Homo sapiens	137-142
19636199-4	2009	The molecular analysis of CYP17A1 revealed a novel homozygous missense mutation resulting in the substitution of arginine to lysine at the amino acid position 21 (p.R21L).	Lysine	125-131	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	26-33
23095741-4	2012	Numerous studies support the hypothesis that during tRNA(Lys) packaging, a Gag GagPol complex interacts with a tRNA(Lys) LysRS complex, with Gag interacting specifically with the catalytic domain of LysRS, and GagPol interacting with both Gag and tRNA(Lys).	Lysine	57-60	Pr55(Gag)	Human immunodeficiency virus 1	75-78
23095741-4	2012	Numerous studies support the hypothesis that during tRNA(Lys) packaging, a Gag GagPol complex interacts with a tRNA(Lys) LysRS complex, with Gag interacting specifically with the catalytic domain of LysRS, and GagPol interacting with both Gag and tRNA(Lys).	Lysine	57-60	Pr55(Gag)	Human immunodeficiency virus 1	79-82
23095741-4	2012	Numerous studies support the hypothesis that during tRNA(Lys) packaging, a Gag GagPol complex interacts with a tRNA(Lys) LysRS complex, with Gag interacting specifically with the catalytic domain of LysRS, and GagPol interacting with both Gag and tRNA(Lys).	Lysine	57-60	Pr55(Gag)	Human immunodeficiency virus 1	79-82
22824487-3	2012	The N-terminal sequences upstream of TGF-beta-type cysteine-knot domains in BMP-2, 7 and 14 contain the basic residues arginine and lysine, which are key components of the heparin/HS-binding sites, with these residues being highly non-conserved.	Lysine	132-138	bone morphogenetic protein 2	Homo sapiens	76-81
25308486-5	2015	It also serves as a substrate for deacylases SIRT3, SIRT4, and SIRT5, which modify protein posttranslational modifications on lysine within the mitochondrial compartment.	Lysine	126-132	sirtuin 5	Homo sapiens	63-68
19191503-2	2009	Progressive modification of Lys(514) with fluorescein 5-isothiocyanate (FITC), which physically blocks access to the nucleotide binding site by ATP, demonstrates that Ca-ATPase active sites function independently of one another prior to the phosphorylation of PLB.	Lysine	28-31	phospholamban	Homo sapiens	260-263
25284001-2	2015	Cargo proteins interact with the importin-alpha armadillo repeat domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg residues.	Lysine	152-155	importin alpha 	Arabidopsis thaliana	33-47
19000660-4	2009	In another member of the superfamily (ALDH3) this serine residue is an aspartate, which tethers the "distal" Lys.	Lysine	109-112	aldehyde dehydrogenase 3 family member A1	Homo sapiens	38-43
19000660-5	2009	It has been our hypothesis that in ALDH3 this is a beneficial interaction, enabling the "proximal" Lys to interact with the carbonyl oxygen of the peptide bond with the catalytic Cys, allowing the Cys amide N to transiently protonate the tetrahedral intermediate.	Lysine	99-102	aldehyde dehydrogenase 3 family member A1	Homo sapiens	35-40
19265141-4	2009	Pt-KIR2DL6 and 2DL8 were demonstrated to be inhibitory C1 receptors with a specificity and specificity-determining residue (lysine 44) like KIR2DL3.	Lysine	124-130	killer cell immunoglobulin like receptor, two Ig domains pseudogene 1	Homo sapiens	3-10
19265141-9	2009	Reconstruction of the ancestral hominoid KIR sequence shows it encoded lysine 44, indicating that KIR having methionine 44 and glutamate 44 subsequently evolved by independent point substitutions.	Lysine	71-77	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	41-44
19265141-9	2009	Reconstruction of the ancestral hominoid KIR sequence shows it encoded lysine 44, indicating that KIR having methionine 44 and glutamate 44 subsequently evolved by independent point substitutions.	Lysine	71-77	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	98-101
19117940-2	2009	Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta.	Lysine	76-82	membrane associated ring-CH-type finger 1	Homo sapiens	16-23
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Lysine	160-166	karyopherin beta	Saccharomyces cerevisiae S288C	71-76
22974122-0	2012	Regulation of fibrinolysis by C-terminal lysines operates through plasminogen and plasmin but not tissue-type plasminogen activator.	Lysine	41-48	plasminogen	Homo sapiens	66-77
22974122-0	2012	Regulation of fibrinolysis by C-terminal lysines operates through plasminogen and plasmin but not tissue-type plasminogen activator.	Lysine	41-48	plasminogen	Homo sapiens	66-73
25494638-0	2014	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	Lysine	17-23	nuclear receptor binding SET domain protein 1	Homo sapiens	39-43
25494638-0	2014	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	Lysine	17-23	nuclear receptor binding SET domain protein 3	Homo sapiens	66-70
19126539-7	2009	In keeping with a major contribution of the lysine-binding sites in plasmin for interaction with the factor VIII light chain, analysis of the A3 sequence revealed two regions involving clustered lysine residues in 1690-1705 and 1804-1818.	Lysine	44-50	plasminogen	Homo sapiens	68-75
25494638-8	2014	CONCLUSIONS: Our data highlight the versatility of NSD1, NSD2, and NSD3 for recognizing and methylating several histone lysine marks on histones H3 and H4.	Lysine	120-126	nuclear receptor binding SET domain protein 1	Homo sapiens	51-55
22988082-4	2012	These training effects were induced through the NOD2 receptor and mediated by increased histone 3 lysine 4 trimethylation.	Lysine	98-104	nucleotide-binding oligomerization domain containing 2	Mus musculus	48-52
25494638-8	2014	CONCLUSIONS: Our data highlight the versatility of NSD1, NSD2, and NSD3 for recognizing and methylating several histone lysine marks on histones H3 and H4.	Lysine	120-126	nuclear receptor binding SET domain protein 3	Homo sapiens	67-71
19223581-2	2009	Previous studies have shown that Lys-28 in the activation domain (AD) of Tat is essential for HIV-1 transcription and replication and is acetylated by p300/CBP-associated factor (PCAF), but the mechanistic basis of the Lys-28 requirement is unknown.	Lysine	33-36	lysine acetyltransferase 2B	Bos taurus	179-183
25487737-0	2014	Critical role of lysine 134 methylation on histone H2AX for gamma-H2AX production and DNA repair.	Lysine	17-23	H2A.X variant histone	Homo sapiens	51-55
19223581-2	2009	Previous studies have shown that Lys-28 in the activation domain (AD) of Tat is essential for HIV-1 transcription and replication and is acetylated by p300/CBP-associated factor (PCAF), but the mechanistic basis of the Lys-28 requirement is unknown.	Lysine	219-222	lysine acetyltransferase 2B	Bos taurus	179-183
22902629-4	2012	To investigate the role of these contacts in reactions involving circular clamps, we examined single arginine/lysine mutants of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clamp onto primer template DNA (ptDNA).	Lysine	110-116	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	153-187
22902629-4	2012	To investigate the role of these contacts in reactions involving circular clamps, we examined single arginine/lysine mutants of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clamp onto primer template DNA (ptDNA).	Lysine	110-116	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	189-193
19216533-0	2009	Lysine methylation of nuclear co-repressor receptor interacting protein 140.	Lysine	0-6	nuclear receptor interacting protein 1	Mus musculus	43-75
25487737-0	2014	Critical role of lysine 134 methylation on histone H2AX for gamma-H2AX production and DNA repair.	Lysine	17-23	H2A.X variant histone	Homo sapiens	60-70
19216533-4	2009	Here, we find that endogenous RIP140 in differentiated 3T3-L1 cells is also modified by lysine methylation.	Lysine	88-94	nuclear receptor interacting protein 1	Mus musculus	30-36
19216533-8	2009	Kinetic analysis of PTMs of endogenous RIP140 in differentiated 3T3-L1 cells demonstrates sequential modifications on RIP140, initiated from constitutive lysine methylation, followed by increased arginine methylation later in differentiation.	Lysine	154-160	nuclear receptor interacting protein 1	Mus musculus	39-45
22918831-2	2012	Lysine autoacetylation of the MYST HATs has recently received considerable attention.	Lysine	0-6	lysine acetyltransferase 8	Homo sapiens	30-34
25487737-3	2014	Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134.	Lysine	83-89	SUV39H2 histone lysine methyltransferase	Homo sapiens	48-55
19216533-8	2009	Kinetic analysis of PTMs of endogenous RIP140 in differentiated 3T3-L1 cells demonstrates sequential modifications on RIP140, initiated from constitutive lysine methylation, followed by increased arginine methylation later in differentiation.	Lysine	154-160	nuclear receptor interacting protein 1	Mus musculus	118-124
19103749-1	2009	Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression of inflammatory genes.	Lysine	60-66	RELA proto-oncogene, NF-kB subunit	Homo sapiens	19-23
19103749-4	2009	Bromodomains of Brd4 and acetylated lysine-310 of RelA are both required for the mutual interaction and coactivation function of Brd4.	Lysine	36-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	50-54
19103749-6	2009	Our results identify Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA.	Lysine	105-111	RELA proto-oncogene, NF-kB subunit	Homo sapiens	119-123
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	79-82	interleukin 9	Homo sapiens	48-51
22909820-4	2012	This occurs both through antagonism of RNF8/RNF168-mediated lysine 63-linked poly-Ub and through the promotion of JMJD2A retention on chromatin.	Lysine	60-66	ring finger protein 168	Homo sapiens	44-50
25487737-3	2014	Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134.	Lysine	83-89	H2A.X variant histone	Homo sapiens	75-79
25213862-5	2014	Our data suggest that following ligand binding-induced cleavage of the Lys(629)-PLP covalent bond, dynamic motion of the cobalamin-binding domain leads to conformational sampling of the available space.	Lysine	71-74	pyridoxal phosphatase	Homo sapiens	80-83
22918947-0	2012	Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.	Lysine	50-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	26-30
22918947-1	2012	Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic endonuclease in the base excision repair (BER) pathway of DNA lesions caused by oxidation/alkylation in mammalian cells; within nucleoli it interacts with nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)/K(32)/K(35)) may undergo acetylation in vivo.	Lysine	260-263	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-36
19234531-3	2009	We have used mass spectrometry in conjunction with cell synchronization, metabolic labeling, RNA interference, and other approaches to show that the SET domain proteins PR-Set7 and Suv4-20 mediate progressive global mono-, di-, and trimethylation of lysine 20 (K20) in newly synthesized histone H4, beginning approximately at the G2/M transition, well after new H4 is deposited in replicating chromatin during S phase.	Lysine	250-256	lysine methyltransferase 5A	Homo sapiens	169-176
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	121-127	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	193-198
22918947-1	2012	Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic endonuclease in the base excision repair (BER) pathway of DNA lesions caused by oxidation/alkylation in mammalian cells; within nucleoli it interacts with nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)/K(32)/K(35)) may undergo acetylation in vivo.	Lysine	260-263	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	38-42
22918947-7	2012	These results highlight the emerging role of acetylation of critical Lys residues in regulating APE1 functions.	Lysine	69-72	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	96-100
25315771-8	2014	The appositional surfaces include Lys-88, Arg-347, and Arg-358/Arg-449 of CYP17A1, which interact with Glu-61, Glu-42, and Glu-48/Glu-49 of b5, respectively.	Lysine	34-37	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	74-81
22918947-8	2012	They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo.	Lysine	64-67	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	80-84
22918947-8	2012	They also suggest the existence of cross-talk between different Lys residues of APE1 occurring upon genotoxic damage, which may modulate APE1 subnuclear distribution and enzymatic activity in vivo.	Lysine	64-67	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	137-141
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	237-243	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	193-198
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Lysine	86-89	taste 1 receptor member 1	Homo sapiens	31-35
19230066-0	2009	Detection of Hb E mutation (beta(26), GAG-AAG, Glu-Lys) using allelic discrimination analysis.	Lysine	51-54	hemoglobin subunit epsilon 1	Homo sapiens	13-17
22723015-10	2012	Alterations in the methylation of lysines 4 and 27 of histone H3 were detected in the promoter region of PAX6 and OCT4.	Lysine	34-41	paired box 6	Homo sapiens	105-109
25331670-4	2014	The molecular docking study of T1R1 and T1R3 in complex with four peptides, including Lys-Gly-Asp-Glu-Ser-Leu-Leu-Ala, Ser-Glu-Glu, G1u-Ser, and Asp-Glu-Ser, displayed that the amino acid residue of SER146 and Glu277 in T1R3 may play great roles in the synergism of umami taste.	Lysine	86-89	taste 1 receptor member 3	Homo sapiens	40-44
19160459-7	2009	The specific attachment sites of nonenzymatically biotinylated recombinant H2A at different time points were identified using mass spectrometry, and were found to consist of a similar pattern of biotin attachment as seen in the presence of HCS, with preference for lysines in the highly basic N-terminal region of the histone.	Lysine	265-272	H2A clustered histone 18	Homo sapiens	75-78
25378304-1	2014	The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3).	Lysine	20-26	lysine demethylase 4D	Homo sapiens	40-45
19475480-4	2009	Infection with viruses containing a lysine at NP 184 induced earlier mortality in chickens, increased virus titers and nitric oxide levels in tissues, and resulted in up-regulated host immune genes, such as alpha-interferon (IFN-alpha), gamma-interferon (IFN-gamma), orthomyxovirus resistance gene 1 (Mx1), and inducible nitric oxide synthase (iNOS).	Lysine	36-42	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Gallus gallus	301-304
22728919-6	2012	Analysis of the AHR proximal promoter region using chromatin immunoprecipitation confirmed that enhanced expression of AhR in LTEE cells involves changes in histone modifications, notably decreased trimethylation of histone 3, lysine 27.	Lysine	227-233	aryl hydrocarbon receptor	Homo sapiens	16-19
22728919-6	2012	Analysis of the AHR proximal promoter region using chromatin immunoprecipitation confirmed that enhanced expression of AhR in LTEE cells involves changes in histone modifications, notably decreased trimethylation of histone 3, lysine 27.	Lysine	227-233	aryl hydrocarbon receptor	Homo sapiens	119-122
22878891-7	2012	Here, we report that histone H3 acetylation (H3Ac) and H3 lysine 4 tri-methylation (H3K4me3) levels at LHY, CCA1, and TOC1 are positively correlated with the rhythmic transcript levels of these genes, whereas H3K36me2 level shows a negative correlation.	Lysine	58-64	circadian clock associated 1	Arabidopsis thaliana	108-112
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	43-49	proteolipid protein 1	Rattus norvegicus	133-152
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	43-49	proteolipid protein 1	Rattus norvegicus	154-157
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	56-62	proteolipid protein 1	Rattus norvegicus	133-152
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	56-62	proteolipid protein 1	Rattus norvegicus	154-157
25137013-1	2014	SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	0-5
19107417-2	2009	Although Ubc9 can directly recognize and modify substrate lysine residues that occur within a consensus site for SUMO modification, E3 ligases can redirect specificity and enhance conjugation rates during SUMO conjugation in vitro and in vivo.	Lysine	58-64	ubiquitin conjugating enzyme E2 I	Homo sapiens	9-13
22705796-5	2012	Our data show that Srs2 is sumoylated at three lysines, and its sumoylation is facilitated by the Siz SUMO ligases.	Lysine	47-54	DNA helicase SRS2	Saccharomyces cerevisiae S288C	19-23
25137013-1	2014	SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	6-10
25137013-1	2014	SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	11-18
25137013-1	2014	SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo.	Lysine	45-51	lysine methyltransferase 5A	Homo sapiens	19-24
25154026-1	2014	EZH2 and EZH1 are protein methyltransferases (PMTs) responsible for histone H3, lysine 27 (H3K27) methylation.	Lysine	80-86	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	9-13
22827639-1	2012	Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers.	Lysine	145-151	carboxypeptidase B2	Homo sapiens	0-43
22827639-1	2012	Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers.	Lysine	145-151	carboxypeptidase B2	Homo sapiens	45-49
18987336-5	2009	The key ubiquitination sites Lys-19 and Lys-49 of beta-catenin were shown as the critical residues for PCAF-induced acetylation and stabilization.	Lysine	29-32	K(lysine) acetyltransferase 2B	Mus musculus	103-107
18987336-5	2009	The key ubiquitination sites Lys-19 and Lys-49 of beta-catenin were shown as the critical residues for PCAF-induced acetylation and stabilization.	Lysine	40-43	K(lysine) acetyltransferase 2B	Mus musculus	103-107
25290883-0	2014	Substitution of the Lys linker with the beta-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated alpha-melanocyte stimulating hormone peptides.	Lysine	20-23	pro-opiomelanocortin-alpha	Mus musculus	159-195
19079244-6	2009	IR treatments lead to a global increase in the acetylation of Lys 14 of histone H3 (H3K14) in an HMGN1-dependent manner and treatment of cells with histone deacetylase inhibitors bypasses the HMGN1 requirement for efficient ATM activation.	Lysine	62-65	high mobility group nucleosome binding domain 1	Homo sapiens	97-102
19079244-6	2009	IR treatments lead to a global increase in the acetylation of Lys 14 of histone H3 (H3K14) in an HMGN1-dependent manner and treatment of cells with histone deacetylase inhibitors bypasses the HMGN1 requirement for efficient ATM activation.	Lysine	62-65	high mobility group nucleosome binding domain 1	Homo sapiens	192-197
18854179-3	2008	We showed that CoREST can be modified by SUMO-1 at lysine 294.	Lysine	51-57	small ubiquitin like modifier 1	Homo sapiens	41-47
22902903-3	2012	SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, lysine malonylation and succinylation.	Lysine	165-171	sirtuin 5	Homo sapiens	107-112
22822061-6	2012	Single- or multiple-site mutants at five positively charged residues of LRR11 (LRR11m1-9), especially Arg-337 and Lys-367, were shown to contribute to hTLR9 binding of CpG ODN.	Lysine	114-117	toll like receptor 9	Homo sapiens	151-156
25290883-1	2014	The purpose of this study was to examine whether the substitution of the Lys linker with the beta-Ala could reduce the renal uptake of (99m)Tc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) peptides.	Lysine	73-76	pro-opiomelanocortin-alpha	Mus musculus	197-233
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Lysine	77-80	toll like receptor 9	Homo sapiens	20-25
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Lysine	144-147	toll like receptor 9	Homo sapiens	20-25
25290883-1	2014	The purpose of this study was to examine whether the substitution of the Lys linker with the beta-Ala could reduce the renal uptake of (99m)Tc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) peptides.	Lysine	73-76	pro-opiomelanocortin-alpha	Mus musculus	235-244
22825850-4	2012	In the present work, we show that hnRNP K is modified by SUMO in lysine 422 within its KH3 domain, and sumoylation is regulated by the E3 ligase Pc2/CBX4.	Lysine	65-71	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	34-41
24659483-7	2014	Allosteric inhibitors of plasmin have also been designed including small molecule lysine analogs that bind to plasmin"s kringle domain(s) and sulfated glycosaminoglycan mimetics that bind to plasmin"s catalytic domain.	Lysine	82-88	plasminogen	Homo sapiens	25-32
22871331-2	2012	Polycomb group proteins EED, SUZ12, and EZH2 have been shown to mediate methylation of the lysine 27 residue of histone protein H3 (H3K27), an epigenetic mark that is linked with transcriptional repression.	Lysine	91-97	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	29-34
19088188-4	2008	To elucidate the mechanism underlying this switch, we have characterized a Phe/Tyr switch mutant of the histone H4 Lys-20 (H4K20) methyltransferase SET8, which alters its specificity from a monomethyltransferase to a dimethyltransferase.	Lysine	115-118	lysine methyltransferase 5A	Homo sapiens	148-152
19088188-5	2008	The crystal structures of the SET8 Y334F mutant bound to histone H4 peptides bearing unmodified, monomethyl, and dimethyl Lys-20 reveal that the phenylalanine substitution attenuates hydrogen bonding to a structurally conserved water molecule adjacent to the Phe/Tyr switch, facilitating its dissociation.	Lysine	122-125	lysine methyltransferase 5A	Homo sapiens	30-34
18826953-5	2008	Mutations within PrP 98-110, substituting all 4 wild-type lysine residues with alanine residues, prevented conversion to PrP(Sc).	Lysine	58-64	prion protein	Mus musculus	17-20
18826953-5	2008	Mutations within PrP 98-110, substituting all 4 wild-type lysine residues with alanine residues, prevented conversion to PrP(Sc).	Lysine	58-64	prion protein	Mus musculus	121-124
18956849-3	2008	RNase A was immobilized as a model enzyme through the nucleophilic attack of azlactone by the amine groups in the lysines located in the protein.	Lysine	114-121	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
25226840-9	2014	In addition, the presence of L-Lys (10 microM) significantly blocked the L-Arg (1,000 microM)-induced reduction in soluble ECE-1 levels (122.38 +- 13.16).	Lysine	29-34	Rho guanine nucleotide exchange factor 12	Homo sapiens	73-78
18787944-1	2008	Hemoglobin E (HbE; beta26Glu --&gt; Lys) is the most common variant of the beta-globin gene in Southeast Asia; it has been suggested that it confers resistance against Plasmodium falciparum malaria.	Lysine	36-39	hemoglobin subunit epsilon 1	Homo sapiens	14-17
22521726-2	2012	We proved that the AK inhibitor MK-0457 induces the growth arrest DNA damage-inducible (Gadd) 45a through recruitment of octamer-binding (Oct)-1 transcription factor at a critical promoter region for gene transcription and covalent modifications of histone H3 (lysine 14 acetylation, lysine 9 de-methylation).	Lysine	261-267	growth arrest and DNA damage inducible alpha	Homo sapiens	52-97
22521726-2	2012	We proved that the AK inhibitor MK-0457 induces the growth arrest DNA damage-inducible (Gadd) 45a through recruitment of octamer-binding (Oct)-1 transcription factor at a critical promoter region for gene transcription and covalent modifications of histone H3 (lysine 14 acetylation, lysine 9 de-methylation).	Lysine	284-290	growth arrest and DNA damage inducible alpha	Homo sapiens	52-97
25225294-4	2014	Two residues of IRE1, Lys(545) and Lys(828), were targeted for Lys(63)-linked ubiquitination.	Lysine	22-25	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
22746826-3	2012	Here, we identify an N-terminal lysine-rich nucleolar localization signal (NoLS) in the AMV CP required to both enter the nucleus and accumulate in the nucleolus of infected cells, and a C-terminal leucine-rich domain which might function as a nuclear export signal.	Lysine	32-38	coat protein	Alfalfa mosaic virus	92-94
22746826-7	2012	In vitro analysis demonstrated that specific lysine residues within the NoLS are also involved in modulating CP-RNA binding and CP dimerization, suggesting that the NoLS represents a multifunctional domain within the AMV CP.	Lysine	45-51	coat protein	Alfalfa mosaic virus	109-111
18815279-6	2008	A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues.	Lysine	133-140	E1A binding protein p300	Homo sapiens	205-209
18815279-6	2008	A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues.	Lysine	133-140	E1A binding protein p300	Homo sapiens	205-209
22746826-7	2012	In vitro analysis demonstrated that specific lysine residues within the NoLS are also involved in modulating CP-RNA binding and CP dimerization, suggesting that the NoLS represents a multifunctional domain within the AMV CP.	Lysine	45-51	coat protein	Alfalfa mosaic virus	128-130
25225294-4	2014	Two residues of IRE1, Lys(545) and Lys(828), were targeted for Lys(63)-linked ubiquitination.	Lysine	35-38	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
18824541-6	2008	Lysine residues at positions 410 and 411 in a putative TRAF6 consensus binding domain of IRF-5 are the targets of K63-linked ubiquitination.	Lysine	0-6	interferon regulatory factor 5	Homo sapiens	89-94
18824541-7	2008	Mutagenesis of these two lysines abolished IRF-5 ubiquitination, nuclear translocation, and the IFNA promoter-inducing activity but not the IRF-5-TRAF6 interaction.	Lysine	25-32	interferon regulatory factor 5	Homo sapiens	43-48
25225294-4	2014	Two residues of IRE1, Lys(545) and Lys(828), were targeted for Lys(63)-linked ubiquitination.	Lysine	35-38	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	16-20
25225294-5	2014	Moreover, in CHIP knockdown cells, IRE1 phosphorylation and the IRE1-TRAF2 interaction were nearly abolished under ER stress, which may be due to lacking ubiquitination of IRE1 on Lys(545) and Lys(828), respectively.	Lysine	193-196	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	35-39
22539680-6	2012	Taking advantage of this experimental sex reversal model, we show that the epigenetic sex marks in the CYP19A1/aromatase promoter involving DNA methylation and histone lysine methylation are feminized significantly but only partially in sex-converted gonads even when morphological and transcriptional marks of sex differentiation show complete feminization, being indistinguishable from gonads of normal ZW females.	Lysine	168-174	cytochrome P450 family 19 subfamily A member 1	Gallus gallus	103-110
25225294-5	2014	Moreover, in CHIP knockdown cells, IRE1 phosphorylation and the IRE1-TRAF2 interaction were nearly abolished under ER stress, which may be due to lacking ubiquitination of IRE1 on Lys(545) and Lys(828), respectively.	Lysine	193-196	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	64-68
18799463-6	2008	We found that: 1) histone H3 and H4 acetylation in the 15-LOX-1 promoter through KAT3B was critical to 15-LOX-1 transcriptional activation; 2) 15-LOX-1 transcription was activated independently from STAT-6; and 3) dimethyl-histone H3 lysine 9 (H3K9me2) demethylation in the 15-LOX-1 promoter via the histone lysine demethylase KDM3A was an early and specific histone modification and was necessary for activation of transcription.	Lysine	234-240	E1A binding protein p300	Homo sapiens	81-86
25225294-5	2014	Moreover, in CHIP knockdown cells, IRE1 phosphorylation and the IRE1-TRAF2 interaction were nearly abolished under ER stress, which may be due to lacking ubiquitination of IRE1 on Lys(545) and Lys(828), respectively.	Lysine	193-196	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	64-68
25231979-4	2014	The human FAM86A (family with sequence similarity 86) protein belongs to a recently identified family of protein MTases, and we here show that FAM86A catalyzes the trimethylation of eukaryotic elongation factor 2 (eEF2) on Lys-525.	Lysine	223-226	eukaryotic elongation factor 2 lysine methyltransferase	Homo sapiens	10-16
18988736-6	2008	It is proposed that, in both cases, a protonated basic residue (Arg-37 in the case of human UroD; Lys-93 in the case of yeast ODCase) furnishes a counterion that helps the scissile carboxylate group of the substrate leave water and enter a relatively nonpolar environment, stabilizes the incipient carbanion generated by the departure of CO(2), and supplies the proton that takes its place.	Lysine	98-101	uroporphyrinogen decarboxylase	Homo sapiens	92-96
22677101-6	2012	However, we report a novel age-related accumulation of intraneuronal lysine 48-specific polyubiquitin-positive granular staining in both wild-type and heterozygous Psmc1 knockout mouse brain.	Lysine	69-75	protease (prosome, macropain) 26S subunit, ATPase 1	Mus musculus	164-169
22870576-2	2012	The frequency of ALDH2 gene G/A polymorphism (with the substitution of glutamic acid to lysine) varies widely among ethnic groups; the polymorphism is prevalent among Asian people but rare in other ethnic groups.	Lysine	88-94	aldehyde dehydrogenase 2 family member	Homo sapiens	17-22
25231979-4	2014	The human FAM86A (family with sequence similarity 86) protein belongs to a recently identified family of protein MTases, and we here show that FAM86A catalyzes the trimethylation of eukaryotic elongation factor 2 (eEF2) on Lys-525.	Lysine	223-226	eukaryotic elongation factor 2 lysine methyltransferase	Homo sapiens	143-149
18776185-0	2008	Apolipoprotein(a), through its strong lysine-binding site in KIV(10"), mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway.	Lysine	38-44	lipoprotein(a)	Homo sapiens	0-17
18776185-0	2008	Apolipoprotein(a), through its strong lysine-binding site in KIV(10"), mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway.	Lysine	38-44	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	157-162
25231979-5	2014	Moreover, we demonstrate that the Saccharomyces cerevisiae MTase Yjr129c, which displays sequence homology to FAM86A, is a functional FAM86A orthologue, modifying the corresponding residue (Lys-509) in yeast eEF2, both in vitro and in vivo.	Lysine	190-193	eukaryotic elongation factor 2 lysine methyltransferase	Homo sapiens	110-116
25231979-5	2014	Moreover, we demonstrate that the Saccharomyces cerevisiae MTase Yjr129c, which displays sequence homology to FAM86A, is a functional FAM86A orthologue, modifying the corresponding residue (Lys-509) in yeast eEF2, both in vitro and in vivo.	Lysine	190-193	eukaryotic elongation factor 2 lysine methyltransferase	Homo sapiens	134-140
25231979-7	2014	In summary, the present study establishes the function of the previously uncharacterized MTases FAM86A and Yjr129c, demonstrating that these enzymes introduce a functionally important lysine methylation in eEF2.	Lysine	184-190	eukaryotic elongation factor 2 lysine methyltransferase	Homo sapiens	96-102
18995842-4	2008	SIRT2 deacetylates lysine residues in the catalytic domain of p300 and restores binding of p300 to the PIC.	Lysine	19-25	E1A binding protein p300	Homo sapiens	62-66
25231983-3	2014	Here we show that in Saccharomyces cerevisiae, the product of the EFM3/YJR129C gene is responsible for the trimethylation of lysine 509 on elongation factor 2.	Lysine	125-131	protein-lysine N-methyltransferase	Saccharomyces cerevisiae S288C	66-78
25310986-1	2014	Histone H3 Lys 4 methylation (H3K4me) is deposited by the conserved SET1/MLL methyltransferases acting in multiprotein complexes, including Ash2 and Wdr5.	Lysine	11-14	B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2	Caenorhabditis elegans	140-144
18986391-1	2008	Thrombin activatable fibrinolysis inhibitor [carboxypeptidase B2 (plasma), CPB2] is a basic carboxypeptidase, which inhibits fibrinolysis by cleaving the C-terminal lysine residues on plasmin-modified partially degraded fibrin.	Lysine	165-171	carboxypeptidase B2	Homo sapiens	0-43
18986391-1	2008	Thrombin activatable fibrinolysis inhibitor [carboxypeptidase B2 (plasma), CPB2] is a basic carboxypeptidase, which inhibits fibrinolysis by cleaving the C-terminal lysine residues on plasmin-modified partially degraded fibrin.	Lysine	165-171	carboxypeptidase B2	Homo sapiens	45-73
18986391-1	2008	Thrombin activatable fibrinolysis inhibitor [carboxypeptidase B2 (plasma), CPB2] is a basic carboxypeptidase, which inhibits fibrinolysis by cleaving the C-terminal lysine residues on plasmin-modified partially degraded fibrin.	Lysine	165-171	carboxypeptidase B2	Homo sapiens	75-79
22751501-3	2012	Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1.	Lysine	63-70	structural maintenance of chromosomes 5	Homo sapiens	22-28
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	0-6	lysine acetyltransferase 8	Homo sapiens	58-62
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	0-6	lysine acetyltransferase 8	Homo sapiens	139-143
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	47-54	lysine acetyltransferase 8	Homo sapiens	58-62
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	47-54	lysine acetyltransferase 8	Homo sapiens	139-143
25187518-9	2014	The mitochondrial translocation of GSK-3beta was attenuated also when Lys-15, but not Arg-4 or Arg-6, in the N-terminal domain of GSK-3beta was replaced with alanine.	Lysine	70-73	glycogen synthase kinase 3 beta	Homo sapiens	35-44
22402492-5	2012	DNA damage stimulates sumoylation of BMI1 by CBX4 at lysine 88, which is required for the accumulation of BMI1 at DNA damage sites.	Lysine	53-59	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	106-110
22555612-2	2012	Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1.	Lysine	61-67	small ubiquitin like modifier 1	Homo sapiens	52-57
19506739-3	2008	Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin.	Lysine	60-66	Polycomb	Drosophila melanogaster	30-33
25187518-9	2014	The mitochondrial translocation of GSK-3beta was attenuated also when Lys-15, but not Arg-4 or Arg-6, in the N-terminal domain of GSK-3beta was replaced with alanine.	Lysine	70-73	glycogen synthase kinase 3 beta	Homo sapiens	130-139
19506739-3	2008	Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin.	Lysine	181-187	Polycomb	Drosophila melanogaster	30-33
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Lysine	107-110	defensin, alpha, 4	Mus musculus	46-62
25319830-6	2014	Also, the intramolecular interaction of the Snf2 bromodomain with the acetylated lysine residues on Snf2 negatively regulates binding and remodeling of acetylated nucleosomes by Swi/Snf.	Lysine	81-87	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	44-48
22440150-3	2012	Poly(acrylic acid) hydrogels were synthesized by UV polymerization and pendant MMP-2 sensitive peptides (Gly-Pro-Leu-Gly-Val-Arg-Gly-Lys) conjugated throughout using EDC/sulfo-NHS chemistry.	Lysine	133-136	matrix metallopeptidase 2	Homo sapiens	79-84
18669641-1	2008	Mature thrombin-activable fibrinolysis inhibitor (TAFIa) is a highly unstable metallocarboxypeptidase that stabilizes blood clots by clipping C-terminal lysine residues from partially degraded fibrin.	Lysine	153-159	carboxypeptidase B2	Homo sapiens	7-48
25319830-6	2014	Also, the intramolecular interaction of the Snf2 bromodomain with the acetylated lysine residues on Snf2 negatively regulates binding and remodeling of acetylated nucleosomes by Swi/Snf.	Lysine	81-87	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	100-104
18706910-0	2008	The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.	Lysine	92-98	Scm polycomb group protein like 2	Homo sapiens	43-48
25222106-9	2014	These data from complementary approaches support a mechanism for loss of plasmin activity resulting from C-terminal lysine-dependent redistribution of enzyme molecules on the fibrin surface.	Lysine	116-122	plasminogen	Homo sapiens	73-80
18832703-3	2008	The sequence of residues 111-129 of MBP (MBP(111-129)) differs in humans (MBP122:Arg) and mice (MBP122:Lys) at aa 122.	Lysine	103-106	myelin basic protein	Homo sapiens	36-39
18832703-3	2008	The sequence of residues 111-129 of MBP (MBP(111-129)) differs in humans (MBP122:Arg) and mice (MBP122:Lys) at aa 122.	Lysine	103-106	myelin basic protein	Homo sapiens	41-44
25172487-4	2014	In this study, we report that TRIM33, a member of the tripartite motif (TRIM) family, can bind DHX33 directly and induce DHX33 ubiquitination via the lysine 218 upon dsRNA stimulation.	Lysine	150-156	tripartite motif containing 33	Homo sapiens	30-36
18513492-9	2008	Instead, the ING2-associated HMT shows an increased methylation activity if lysine 9 is methylated.	Lysine	76-82	inhibitor of growth family member 2	Homo sapiens	13-17
18513492-9	2008	Instead, the ING2-associated HMT shows an increased methylation activity if lysine 9 is methylated.	Lysine	76-82	PR/SET domain 9	Homo sapiens	29-32
18513492-10	2008	In contrast, mutation or methylation of lysine 4, a methylation preferentially detected at active genes, led to a reduction of the ING2-associated HMT.	Lysine	40-46	inhibitor of growth family member 2	Homo sapiens	131-135
18513492-10	2008	In contrast, mutation or methylation of lysine 4, a methylation preferentially detected at active genes, led to a reduction of the ING2-associated HMT.	Lysine	40-46	PR/SET domain 9	Homo sapiens	147-150
22239288-4	2012	RESULTS: The Lys and Glu allele frequencies of the apoL-I gene at the Lys166Glu site in obese and nonobese control groups were 0.830, 0.170 and 0.814, 0.186, respectively.	Lysine	13-16	apolipoprotein L1	Homo sapiens	51-57
22493065-0	2012	Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.	Lysine	112-118	brahma	Drosophila melanogaster	48-51
22493065-2	2012	We previously showed that the Drosophila melanogaster acetyltransferase CREB-binding protein (CBP) acetylates histone H3 lysine 27 (H3K27ac), thereby directly blocking its trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) in Polycomb target genes.	Lysine	121-127	Polycomb	Drosophila melanogaster	201-209
22493065-2	2012	We previously showed that the Drosophila melanogaster acetyltransferase CREB-binding protein (CBP) acetylates histone H3 lysine 27 (H3K27ac), thereby directly blocking its trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) in Polycomb target genes.	Lysine	121-127	Polycomb	Drosophila melanogaster	241-249
18655826-0	2008	Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation.	Lysine	14-20	nuclear receptor interacting protein 1	Homo sapiens	100-106
18655826-2	2008	Previous mass spectrometry studies showed that either phosphorylation or lysine acetylation of RIP140 directly enhanced its trans-repressive activity.	Lysine	73-79	nuclear receptor interacting protein 1	Homo sapiens	95-101
25172487-6	2014	The ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex.	Lysine	41-47	tripartite motif containing 33	Homo sapiens	31-37
18710946-3	2008	By establishing an EKLF-null erythroid line whose closed beta-locus chromatin structure and silent beta-globin gene status can be rescued by retroviral infection of EKLF, we demonstrate the importance of EKLF acetylation at lysine 288 in the recruitment of CBP to the locus, modification of histone H3, occupancy by EKLF, opening of the chromatin structure, and transcription of adult beta-globin.	Lysine	224-230	Kruppel like factor 1	Homo sapiens	19-23
25135975-1	2014	The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wide scale is broadly associated with active gene expression, with its mono-, di- and trimethylated forms differentially enriched at promoter and enhancer and other regulatory sequences.	Lysine	240-246	cullin 4B	Homo sapiens	124-129
18710946-3	2008	By establishing an EKLF-null erythroid line whose closed beta-locus chromatin structure and silent beta-globin gene status can be rescued by retroviral infection of EKLF, we demonstrate the importance of EKLF acetylation at lysine 288 in the recruitment of CBP to the locus, modification of histone H3, occupancy by EKLF, opening of the chromatin structure, and transcription of adult beta-globin.	Lysine	224-230	Kruppel like factor 1	Homo sapiens	165-169
18710946-3	2008	By establishing an EKLF-null erythroid line whose closed beta-locus chromatin structure and silent beta-globin gene status can be rescued by retroviral infection of EKLF, we demonstrate the importance of EKLF acetylation at lysine 288 in the recruitment of CBP to the locus, modification of histone H3, occupancy by EKLF, opening of the chromatin structure, and transcription of adult beta-globin.	Lysine	224-230	Kruppel like factor 1	Homo sapiens	165-169
18710946-3	2008	By establishing an EKLF-null erythroid line whose closed beta-locus chromatin structure and silent beta-globin gene status can be rescued by retroviral infection of EKLF, we demonstrate the importance of EKLF acetylation at lysine 288 in the recruitment of CBP to the locus, modification of histone H3, occupancy by EKLF, opening of the chromatin structure, and transcription of adult beta-globin.	Lysine	224-230	Kruppel like factor 1	Homo sapiens	165-169
18710946-6	2008	These data emphasize the critical nature of lysine acetylation in transcription factor activity and enable us to propose a model of how modified EKLF integrates coactivators, chromatin remodelers, and nucleosomal components to alter epigenetic chromatin structure and stimulate transcription.	Lysine	44-50	Kruppel like factor 1	Homo sapiens	145-149
22522402-3	2012	We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy fiber synapses.	Lysine	109-115	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	59-64
22522402-3	2012	We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy fiber synapses.	Lysine	109-115	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	88-93
22522402-3	2012	We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy fiber synapses.	Lysine	109-115	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	88-93
22787431-3	2012	We show here that APC binds to the nuclear localization sequence of Fen1 (Lys(365)Lys(366)Lys(367)), which prevents entry of Fen1 into the nucleus and participation in Pol-beta-directed long-patch BER.	Lysine	74-77	APC regulator of WNT signaling pathway	Homo sapiens	18-21
18974828-4	2008	PRC1-positive bivalent domains appear functionally distinct as they more efficiently retain lysine 27 tri-methylation upon differentiation, show stringent conservation of chromatin state, and associate with an overwhelming number of developmental regulator gene promoters.	Lysine	92-98	protein regulator of cytokinesis 1	Homo sapiens	0-4
25198515-2	2014	G9a is a histone methyltransferase (HMTase) for histone H3 lysine 9.	Lysine	59-65	euchromatic histone lysine N-methyltransferase 2	Mus musculus	0-3
18674781-7	2008	Interestingly, while Id-1 did not induce HBX-ubiquitination, we found that removal of all the lysine residues of the HBX protein protects it from the effect of Id-1, indicating that ubiquitination is still required for the Id-1-mediated HBX degradation.	Lysine	94-100	inhibitor of DNA binding 1, HLH protein	Homo sapiens	160-164
22787431-3	2012	We show here that APC binds to the nuclear localization sequence of Fen1 (Lys(365)Lys(366)Lys(367)), which prevents entry of Fen1 into the nucleus and participation in Pol-beta-directed long-patch BER.	Lysine	74-77	DNA polymerase beta	Homo sapiens	168-176
18674781-7	2008	Interestingly, while Id-1 did not induce HBX-ubiquitination, we found that removal of all the lysine residues of the HBX protein protects it from the effect of Id-1, indicating that ubiquitination is still required for the Id-1-mediated HBX degradation.	Lysine	94-100	inhibitor of DNA binding 1, HLH protein	Homo sapiens	160-164
25059663-5	2014	Strikingly, although TIF1gamma is thought to act as a ubiquitin E3 ligase, we find that TIF1gamma operates as a small ubiquitin-like modifier (SUMO) E3 ligase that promotes the sumoylation of SnoN1 at distinct lysine residues.	Lysine	210-216	tripartite motif-containing 33	Mus musculus	88-97
24997448-2	2014	New isoform contains in addition of loss of N-terminus hexapeptide (as found in parent molecule beta-trypsin) an intra-chain split between Lys-155 and Ser-156.	Lysine	139-142	serine protease 1	Bos taurus	96-108
18757916-2	2008	Rad5 functions in PRR via its two distinct activities--a ubiquitin ligase that promotes Mms2-Ubc13-mediated K63-linked polyubiquitination of PCNA at its lysine 164 residue and a DNA helicase that is specialized for replication fork regression.	Lysine	153-159	DNA helicase RAD5	Saccharomyces cerevisiae S288C	0-4
18757916-2	2008	Rad5 functions in PRR via its two distinct activities--a ubiquitin ligase that promotes Mms2-Ubc13-mediated K63-linked polyubiquitination of PCNA at its lysine 164 residue and a DNA helicase that is specialized for replication fork regression.	Lysine	153-159	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	88-92
22626058-3	2012	RESULTS: We report here that RLR activation triggers MAVS ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling.	Lysine	76-82	tripartite motif containing 25	Homo sapiens	119-125
25049398-0	2014	Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.	Lysine	0-6	RB transcriptional corepressor 1	Homo sapiens	53-56
22474296-10	2012	In addition, site-directed mutagenesis in combination with enzymatic assays suggested that the peroxidase activity of Ahp1 would be altered upon the urmylation (covalently conjugated to ubiquitin-related modifier Urm1) of Lys-32.	Lysine	222-225	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	118-122
22474296-10	2012	In addition, site-directed mutagenesis in combination with enzymatic assays suggested that the peroxidase activity of Ahp1 would be altered upon the urmylation (covalently conjugated to ubiquitin-related modifier Urm1) of Lys-32.	Lysine	222-225	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	213-217
22408254-5	2012	One family of proteins identified in this study was the murine glycine N-acyltransferase (GLYAT) enzymes, which are acetylated on lysine 19.	Lysine	130-136	glycine-N-acyltransferase	Mus musculus	63-88
22408254-5	2012	One family of proteins identified in this study was the murine glycine N-acyltransferase (GLYAT) enzymes, which are acetylated on lysine 19.	Lysine	130-136	glycine-N-acyltransferase	Mus musculus	90-95
18757916-2	2008	Rad5 functions in PRR via its two distinct activities--a ubiquitin ligase that promotes Mms2-Ubc13-mediated K63-linked polyubiquitination of PCNA at its lysine 164 residue and a DNA helicase that is specialized for replication fork regression.	Lysine	153-159	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	93-98
18765789-3	2008	DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4.	Lysine	97-103	BAF nuclear assembly factor 1	Danio rerio	28-31
25049398-2	2014	Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state.	Lysine	0-6	RB transcriptional corepressor 1	Homo sapiens	92-95
25049398-4	2014	Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the role of the 53BP1 tandem tudor domain in recognition of the methylated lysine and surrounding residues.	Lysine	164-170	RB transcriptional corepressor 1	Homo sapiens	66-69
18591252-1	2008	The histone demethylase lysine demethylase 5b (KDM5b) specifically demethylates lysine 4 of histone H3 (meH3K4), thereby repressing gene transcription.	Lysine	24-30	lysine demethylase 5B	Homo sapiens	47-52
22452443-2	2012	The RGD motif {cyclic(Arg-Gly-Asp-D-Tyr-Asp)} was coupled to [Cys(3,4,10), D-Phe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} through a neutral glycine linker to eliminate the positively charged amino side chain of the Lys linker or without a linker to delete the Lys linker.	Lysine	219-222	pro-opiomelanocortin-alpha	Mus musculus	93-102
24682789-4	2014	Here, we identified two essential sites located on the Nt of Aurora-A (Lys 99 and Lys 119) and demonstrate that mutation of either residue to Gly could cause the Nt and C-terminal lobes of the catalytic domain in Aurora-A to form a closed conformation, resulting in a loss of kinase activity.	Lysine	71-74	aurora kinase A	Homo sapiens	61-69
22452443-2	2012	The RGD motif {cyclic(Arg-Gly-Asp-D-Tyr-Asp)} was coupled to [Cys(3,4,10), D-Phe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} through a neutral glycine linker to eliminate the positively charged amino side chain of the Lys linker or without a linker to delete the Lys linker.	Lysine	264-267	pro-opiomelanocortin-alpha	Mus musculus	93-102
18625727-3	2008	We show that several regions of Ci are required for generation of the repressor form: the zinc finger DNA binding domain, a single lysine residue (K750) near the degradation end point, and a 163-amino-acid region at the C terminus.	Lysine	131-137	cubitus interruptus	Drosophila melanogaster	32-34
24682789-4	2014	Here, we identified two essential sites located on the Nt of Aurora-A (Lys 99 and Lys 119) and demonstrate that mutation of either residue to Gly could cause the Nt and C-terminal lobes of the catalytic domain in Aurora-A to form a closed conformation, resulting in a loss of kinase activity.	Lysine	71-74	aurora kinase A	Homo sapiens	213-221
18494853-6	2008	A single residue difference at site 201, which lies adjacent to the residue (lysine 164) ubiquitylated in PCNA, appeared responsible for the inability of PCNA1 to function with AtPoleta in UV-treated yeast.	Lysine	77-83	proliferating cellular nuclear antigen 1	Arabidopsis thaliana	154-159
22411987-8	2012	Evidence is provided that the membrane-proximal lysines at positions 144 and 237, located in the Cx43 intracellular loop and C-terminal tail, respectively, act as SUMO conjugation sites.	Lysine	48-55	gap junction protein alpha 1	Homo sapiens	97-101
22411987-9	2012	Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels.	Lysine	13-19	gap junction protein alpha 1	Homo sapiens	58-62
22411987-9	2012	Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels.	Lysine	13-19	gap junction protein alpha 1	Homo sapiens	87-91
24682789-4	2014	Here, we identified two essential sites located on the Nt of Aurora-A (Lys 99 and Lys 119) and demonstrate that mutation of either residue to Gly could cause the Nt and C-terminal lobes of the catalytic domain in Aurora-A to form a closed conformation, resulting in a loss of kinase activity.	Lysine	82-85	aurora kinase A	Homo sapiens	61-69
24682789-4	2014	Here, we identified two essential sites located on the Nt of Aurora-A (Lys 99 and Lys 119) and demonstrate that mutation of either residue to Gly could cause the Nt and C-terminal lobes of the catalytic domain in Aurora-A to form a closed conformation, resulting in a loss of kinase activity.	Lysine	82-85	aurora kinase A	Homo sapiens	213-221
24952945-5	2014	Here we analyze the NPM1/G-quadruplex interaction, focusing on residues belonging to both the NPM1 terminal three-helix bundle and a lysine-rich unstructured tail, which has been shown to be necessary for high affinity recognition.	Lysine	133-139	nucleophosmin 1	Homo sapiens	20-24
22411987-9	2012	Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels.	Lysine	27-33	gap junction protein alpha 1	Homo sapiens	58-62
22411987-9	2012	Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels.	Lysine	27-33	gap junction protein alpha 1	Homo sapiens	87-91
24928228-3	2014	Replacement of ATP coordinating lysine by alanine yields inactive JAK3(K855A).	Lysine	32-38	Janus kinase 3	Mus musculus	66-70
22560076-4	2012	Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged HSCs, increases the percentage of polarized cells in an aged HSC population, and restores the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs.	Lysine	214-220	cell division cycle 42	Homo sapiens	30-35
18678933-4	2008	A crystal structure of the zebrafish Plk1 kinase domain-inhibitor complex reveals that the small molecule occupies the purine pocket and extends past the catalytic lysine into the adaptive region of the active site.	Lysine	164-170	polo-like kinase 1 (Drosophila)	Danio rerio	37-41
25023514-3	2014	dsirt2 mutant flies displayed increased acetylation of specific Lys residues in ATP synthase beta and decreased complex V activity.	Lysine	64-67	Sirtuin 2	Drosophila melanogaster	0-6
18439917-5	2008	The acetylated-H4 then recruited a transcription factor, NonO, which, in turn, recruited HDACs and induced H3 lysine 9 deacetylation, thereby inhibiting transcription of the P4Halpha1 promoter.	Lysine	110-116	non-POU domain containing octamer binding	Homo sapiens	57-61
18541663-0	2008	Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.	Lysine	85-91	chromatin-remodeling histone chaperone SPT6	Saccharomyces cerevisiae S288C	19-23
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	lysine methyltransferase 2B	Homo sapiens	160-164
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	lysine methyltransferase 2C	Homo sapiens	166-170
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	lysine methyltransferase 2B	Homo sapiens	175-179
24821725-5	2014	shRNA knockdown of HDAC1, HDAC2, or HDAC3 differentially increases the deposition of the histone 3 lysine 27 acetylation (H3K27ac) epigenetic mark associated with increases in these three transcripts.	Lysine	99-105	histone deacetylase 3	Homo sapiens	36-41
22419124-2	2012	The Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, an epigenetic mark that serves as a docking site for the PRC1 protein complex.	Lysine	69-75	Polycomb	Drosophila melanogaster	4-12
22419124-2	2012	The Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, an epigenetic mark that serves as a docking site for the PRC1 protein complex.	Lysine	69-75	protein regulator of cytokinesis 1	Homo sapiens	137-141
18662540-4	2008	Here we show that histone H3 acetylated at lysine 56 (H3K56Ac) is incorporated onto replicating DNA and, by increasing the binding affinity of CAF-1 and Rtt106 for histone H3, H3K56Ac enhances the ability of these histone chaperones to assemble DNA into nucleosomes.	Lysine	43-49	chromatin assembly factor 1 subunit A	Homo sapiens	143-148
25007265-10	2014	p300 was recruited to the promoter regions of OCN and DSPP and might be acting as a coactivator to increase the acetylation of lysine 9 of histone H3 of OCN and DSPP.	Lysine	127-133	E1A binding protein p300	Homo sapiens	0-4
18477475-3	2008	Here, we found that lysine residues (K22, K52, and K55) in the bHLH domain are essential not only for the instability of Hes7 protein but also for the transcriptional repressor activity.	Lysine	20-26	C-C motif chemokine receptor 4	Homo sapiens	51-54
21732356-4	2012	We observed that BMI1 was recruited to UV-damaged chromatin simultaneously with decreased lysine acetylation, followed by the recruitment of heterochromatin protein HP1beta to micro-irradiated regions.	Lysine	90-96	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	17-21
25007265-10	2014	p300 was recruited to the promoter regions of OCN and DSPP and might be acting as a coactivator to increase the acetylation of lysine 9 of histone H3 of OCN and DSPP.	Lysine	127-133	dentin sialophosphoprotein	Homo sapiens	54-58
18441012-3	2008	The crystal structure of FXI demonstrates formation of salt bridges between Lys-331 of one subunit and Glu-287 of the other subunit and hydrophobic interactions at the interface of the Apple 4 domains involving Ile-290, Leu-284, and Tyr-329.	Lysine	76-79	coagulation factor XI	Homo sapiens	25-28
22589192-12	2012	Other modifications observed, in PRDX6 from mouse liver tissues included, among others, mono- and dioxidation at Trp and Met, acetylation at Lys, and deamidation at Asn and Gln.	Lysine	141-144	peroxiredoxin 6	Mus musculus	33-38
25007265-10	2014	p300 was recruited to the promoter regions of OCN and DSPP and might be acting as a coactivator to increase the acetylation of lysine 9 of histone H3 of OCN and DSPP.	Lysine	127-133	dentin sialophosphoprotein	Homo sapiens	161-165
24999627-2	2014	Both proteins also contain JmjC histone demethylase domains, but only Rph1 is known to be an active enzyme, demethylating lysine 36 of histone H3.	Lysine	122-128	Rph1p	Saccharomyces cerevisiae S288C	70-74
22553890-11	2004	(68)Ga-1,4,7,10-Tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid-aminohexanoic acid-Lys(40)-exendin-4 ([Lys(40)(Ahx-DOTA-(68)Ga)NH2]-exendin-4) is being developed for positron emission tomography (PET) imaging of the GLP-1 receptor (6).	Lysine	88-91	glucagon like peptide 1 receptor	Homo sapiens	221-235
22553894-11	2004	(99m)Tc-Hydrazinonicotinamide-aminohexanoic acid-Lys(40)-exendin-4 ([Lys(40)(Ahx-HYNIC-(99m)Tc)NH2]-exendin-4) is being developed for single-photon emission computed tomography (SPECT) imaging of the GLP-1 receptor (6).	Lysine	49-52	glucagon like peptide 1 receptor	Homo sapiens	200-214
22375010-7	2012	Second, Drd2 transcriptional activation is partially antagonized by heterochromatin protein 1 (HP1), the code reader for histone H3 lysine 9 methylation.	Lysine	132-138	dopamine receptor D2	Homo sapiens	8-12
18457658-5	2008	Interestingly, Lysine 811 in TrkB was selected for ubiquination, and mutation of Lysine 811 diminished the formation of TRAF6/p62 complex that is necessary for effective ubiquination.	Lysine	15-21	neurotrophic receptor tyrosine kinase 2	Homo sapiens	29-33
18418832-2	2008	The dipeptide mimetic, which respectively displayed the side chains of tryptophan and lysine at the nitrogen and O6 atoms of the iminosugar scaffold is a ligand (K(i)=3.2 microM) for the human somatostatin receptor subtype 4 (hSSTR4) but has lower affinity (K(i)&gt;100 microM) for hSSTR5.	Lysine	86-92	somatostatin receptor 5	Homo sapiens	282-288
18418832-3	2008	A benzylated analogue of the Trp-Lys mimetic displays higher affinity for hSSTR5 (K(i)=5 microM).	Lysine	33-36	somatostatin receptor 5	Homo sapiens	74-80
18381564-7	2008	Within MRP2 CL3, we identified a lysine-rich element that is essential for apical targeting.	Lysine	33-39	adhesion G protein-coupled receptor L3	Homo sapiens	12-15
24595546-1	2014	The nuclear receptor SET domain-containing family of proteins (NSD1, NSD2, and NSD3) is known to mono- and dimethylate lysine 36 of histone H3 (H3K36).	Lysine	119-125	nuclear receptor binding SET domain protein 1	Homo sapiens	63-67
18458063-6	2008	Another histone chaperone, Asf1, and Vps75 are both required for acetylation of lysine 9 on H3 (H3-K9ac) in vivo by Rtt109, whereas H3-K56ac in vivo requires only Asf1.	Lysine	80-86	Vps75p	Saccharomyces cerevisiae S288C	37-42
24595546-1	2014	The nuclear receptor SET domain-containing family of proteins (NSD1, NSD2, and NSD3) is known to mono- and dimethylate lysine 36 of histone H3 (H3K36).	Lysine	119-125	nuclear receptor binding SET domain protein 3	Homo sapiens	79-83
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	136-139	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
18588675-3	2008	The two best-characterized PcG complexes are the PcG repressive complex 1 (PRC1) and 2 (PRC2) that respectively possess histone 2A lysine 119 E3 ubiquitin ligase and histone 3 lysine 27 methyltransferase activities.	Lysine	131-137	Polycomb	Drosophila melanogaster	27-30
18588675-3	2008	The two best-characterized PcG complexes are the PcG repressive complex 1 (PRC1) and 2 (PRC2) that respectively possess histone 2A lysine 119 E3 ubiquitin ligase and histone 3 lysine 27 methyltransferase activities.	Lysine	131-137	Polycomb	Drosophila melanogaster	49-52
18491920-6	2008	The tail histidine residues, along with two previously identified lysine residues, account for a major part of the polyelectrolyte contribution to binding and for the nonspecific affinity of Mbp1 for DNA.	Lysine	66-72	transcription factor MBP1	Saccharomyces cerevisiae S288C	191-195
22232273-2	2012	Escapin uses L-lysine to produce diverse products called escapin intermediate products of L-lysine (EIP-K), including alpha-amino-epsilon-caproic acid, Delta1-piperidine-2-carboxylic acid, and Delta2-piperidine-2-carboxylic acid.	Lysine	13-21	L-amino-acid oxidase	Aplysia californica	0-7
22232273-2	2012	Escapin uses L-lysine to produce diverse products called escapin intermediate products of L-lysine (EIP-K), including alpha-amino-epsilon-caproic acid, Delta1-piperidine-2-carboxylic acid, and Delta2-piperidine-2-carboxylic acid.	Lysine	13-21	L-amino-acid oxidase	Aplysia californica	57-64
22232273-2	2012	Escapin uses L-lysine to produce diverse products called escapin intermediate products of L-lysine (EIP-K), including alpha-amino-epsilon-caproic acid, Delta1-piperidine-2-carboxylic acid, and Delta2-piperidine-2-carboxylic acid.	Lysine	90-98	L-amino-acid oxidase	Aplysia californica	0-7
22232273-2	2012	Escapin uses L-lysine to produce diverse products called escapin intermediate products of L-lysine (EIP-K), including alpha-amino-epsilon-caproic acid, Delta1-piperidine-2-carboxylic acid, and Delta2-piperidine-2-carboxylic acid.	Lysine	90-98	L-amino-acid oxidase	Aplysia californica	57-64
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Lysine	43-46	Rho family GTPase 1	Homo sapiens	0-4
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	25-28	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	155-158	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
18510351-15	2008	In summary, D-Lys(6)(Ahx-[(18)F]FBOA)-GnRH-I shows the highest potential for efficient GnRHR-targeting in vivo of the compounds investigated.	Lysine	14-17	gonadotropin releasing hormone receptor	Homo sapiens	87-92
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	147-150	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	155-158	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
22262844-2	2012	Lys-63-polyubiquitinated TRAF6 mediates its downstream signaling activation.	Lysine	0-3	TNF receptor-associated factor 6	Danio rerio	25-30
24947936-6	2014	We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.293, 95% CI 1.169-1.430, P = 0.000; Gln/Gln + Gln/lys vs. Lys/Lys: OR = 1.260, 95% CI 1.145-1.388, P = 0.000).	Lysine	155-158	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	21-24
24949976-3	2014	We report the structure of a trapped RING E3-E2~UBL-target intermediate representing RBX1-UBC12~NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.	Lysine	197-203	NEDD8 ubiquitin like modifier	Homo sapiens	96-101
22315223-4	2012	In this study, we report that MT1-MMP is mono-ubiquitinated at its unique lysine residue (Lys(581)) within the ICD.	Lysine	74-80	matrix metallopeptidase 14	Homo sapiens	30-37
22315223-4	2012	In this study, we report that MT1-MMP is mono-ubiquitinated at its unique lysine residue (Lys(581)) within the ICD.	Lysine	90-93	matrix metallopeptidase 14	Homo sapiens	30-37
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Lysine	321-324	F2R like trypsin receptor 1	Homo sapiens	41-46
18396157-1	2008	Thrombin Activatable Fibrinolytic Inhibitor (TAFI) is a plasma protein, which inhibits fibrinolysis by removing carboxyterminal lysine residues from partially degraded fibrin thereby decreasing plasminogen binding on its surface.	Lysine	128-134	carboxypeptidase B2	Homo sapiens	0-43
18396157-1	2008	Thrombin Activatable Fibrinolytic Inhibitor (TAFI) is a plasma protein, which inhibits fibrinolysis by removing carboxyterminal lysine residues from partially degraded fibrin thereby decreasing plasminogen binding on its surface.	Lysine	128-134	carboxypeptidase B2	Homo sapiens	45-49
24949976-3	2014	We report the structure of a trapped RING E3-E2~UBL-target intermediate representing RBX1-UBC12~NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.	Lysine	197-203	cullin 1	Homo sapiens	102-106
18488021-3	2008	Here we report that the HECT-domain ubiquitin ligase Huwe1 ubiquitinates the N-Myc oncoprotein through Lys 48-mediated linkages and targets it for destruction by the proteasome.	Lysine	103-106	HECT, UBA and WWE domain containing 1	Mus musculus	53-58
24949976-3	2014	We report the structure of a trapped RING E3-E2~UBL-target intermediate representing RBX1-UBC12~NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.	Lysine	197-203	NEDD8 ubiquitin like modifier	Homo sapiens	144-149
24835996-0	2014	Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.	Lysine	116-122	E1A binding protein p300	Homo sapiens	39-43
18326498-2	2008	In this study, we showed that IRAK can be ubiquitinated through both Lys-48- and Lys-63-linked polyubiquitin chains upon IL-1 induction.	Lysine	69-72	interleukin 1 receptor associated kinase 1	Homo sapiens	30-34
18326498-2	2008	In this study, we showed that IRAK can be ubiquitinated through both Lys-48- and Lys-63-linked polyubiquitin chains upon IL-1 induction.	Lysine	81-84	interleukin 1 receptor associated kinase 1	Homo sapiens	30-34
18326498-3	2008	Pellino 3b is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked polyubiquitination on IRAK.	Lysine	77-80	interleukin 1 receptor associated kinase 1	Homo sapiens	113-117
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	20-23	interleukin 1 receptor associated kinase 1	Homo sapiens	34-38
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
22439847-2	2012	SUMO conjugation of progesterone receptors (PRs) at the N-terminal lysine (K) 388 residue of PR-B is hormone-dependent and suppresses PR-dependent transcription.	Lysine	67-73	RB transcriptional corepressor 1	Homo sapiens	93-97
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	44-50	S-phase kinase associated protein 2	Homo sapiens	161-165
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Lysine	264-270	S-phase kinase associated protein 2	Homo sapiens	161-165
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
22339618-3	2012	Ubiquitin, a lysine-abundant protein, is used as a model system to demonstrate structural studies using CXLs.	Lysine	13-19	ubiquitin	Saccharomyces cerevisiae S288C	0-9
24835996-0	2014	Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.	Lysine	116-122	forkhead box P3	Homo sapiens	53-58
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
24819397-8	2014	A comparison of these structures with the previously reported p300/Lys-CoA complex demonstrates that the conformation of the enzyme active site depends on the interaction of the enzyme with the cofactor, and is not apparently influenced by protein substrate lysine binding.	Lysine	67-70	E1A binding protein p300	Homo sapiens	62-66
18326498-4	2008	Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1-induced IRAK degradation.	Lysine	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	86-90
22352687-2	2012	The bound complex of Kv1.3 and OSK1 reveals that one lysine residue of the toxin is in the proximity of another lysine residue on the external vestibule of the channel, just outside of the selectivity filter.	Lysine	53-59	potassium voltage-gated channel subfamily A member 3	Homo sapiens	21-26
22352687-2	2012	The bound complex of Kv1.3 and OSK1 reveals that one lysine residue of the toxin is in the proximity of another lysine residue on the external vestibule of the channel, just outside of the selectivity filter.	Lysine	112-118	potassium voltage-gated channel subfamily A member 3	Homo sapiens	21-26
24819397-8	2014	A comparison of these structures with the previously reported p300/Lys-CoA complex demonstrates that the conformation of the enzyme active site depends on the interaction of the enzyme with the cofactor, and is not apparently influenced by protein substrate lysine binding.	Lysine	258-264	E1A binding protein p300	Homo sapiens	62-66
22247554-2	2012	Lys(27) of PLB was cross-linked to the Ca(2+) pump at the cytoplasmic extension of M4 (at or near Lys(328)) with the homobifunctional cross-linker, disuccinimidyl glutarate (7.7 A).	Lysine	0-3	phospholamban	Homo sapiens	11-14
22247554-2	2012	Lys(27) of PLB was cross-linked to the Ca(2+) pump at the cytoplasmic extension of M4 (at or near Lys(328)) with the homobifunctional cross-linker, disuccinimidyl glutarate (7.7 A).	Lysine	98-101	phospholamban	Homo sapiens	11-14
22249179-7	2012	Chromatin remodeling by TIP60 involved the sequential recruitment of acetyl-Lys-310 RelA/p65 to its target gene promoters.	Lysine	76-79	RELA proto-oncogene, NF-kB subunit	Homo sapiens	84-88
22249179-7	2012	Chromatin remodeling by TIP60 involved the sequential recruitment of acetyl-Lys-310 RelA/p65 to its target gene promoters.	Lysine	76-79	RELA proto-oncogene, NF-kB subunit	Homo sapiens	89-92
22135382-9	2012	In addition, acetylation of histone H3 [lysine (Lys9)-acetylated histone H3 (AcK9-H3)] on the promoter region of MIP-2 and CXCR2 was increased in the injured SCN after PSL.	Lysine	40-46	C-X-C motif chemokine receptor 2	Homo sapiens	123-128
22318827-1	2012	PURPOSE: The purpose of the present study was to investigate the aberrance of histone H3 lysine 4 trimethylation (H3K4me3) in patients with IgA Nephropathy (IgAN).	Lysine	89-95	IGAN1	Homo sapiens	157-161
22228774-3	2012	Newly synthesized histone H4 is acetylated at lysine 5 and 12 (H4K5,12) by histone acetyltransferase 1 (HAT1).	Lysine	46-52	histone acetyltransferase 1	Homo sapiens	75-102
22228774-3	2012	Newly synthesized histone H4 is acetylated at lysine 5 and 12 (H4K5,12) by histone acetyltransferase 1 (HAT1).	Lysine	46-52	histone acetyltransferase 1	Homo sapiens	104-108
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	NEDD8 ubiquitin like modifier	Homo sapiens	0-5
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	NEDD8 ubiquitin like modifier	Homo sapiens	7-71
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	ubiquitin	Saccharomyces cerevisiae S288C	108-117
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	ubiquitin	Saccharomyces cerevisiae S288C	184-193
21818117-9	2012	In agreement with the IP(3)R-binding properties, the antiapoptotic activity of BH4-Bcl-2 and BH4-Bcl-Xl was modulated by the Lys/Asp substitutions.	Lysine	125-128	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	22-28
21826105-3	2012	In this study, we report a mouse knock-in allele of Mre11 that substitutes the arginines with lysines in the GAR motif and generates the MRE11(RK) protein devoid of methylated arginines.	Lysine	94-101	MRE11A homolog A, double strand break repair nuclease	Mus musculus	52-57
22117221-1	2012	Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown.	Lysine	64-70	lysine methyltransferase 5A	Homo sapiens	6-13
22117221-1	2012	Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown.	Lysine	64-70	lysine methyltransferase 5A	Homo sapiens	14-19
22117221-1	2012	Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown.	Lysine	64-70	lysine methyltransferase 5A	Homo sapiens	147-152
22142192-5	2012	BmHP1s formed homo- and hetero-dimers and interacted with BmSu(var)3-9, which is a methyltransferase for histone H3 lysine 9 (H3K9).	Lysine	116-122	clip domain serine protease 3	Bombyx mori	0-5
22263694-6	2012	The design of these inhibitors is based on our recent discovery that Sirt5 prefers to catalyze the hydrolysis of malonyl and succinyl groups, rather than an acetyl group, from lysine residues.	Lysine	176-182	sirtuin 5	Homo sapiens	69-74
22371326-9	2012	The overall induction of AOX in wild-type roots correlated with accumulation of glycine, serine, leucine, lysine, and other amino acids.	Lysine	106-112	alternative oxidase 2	Arabidopsis thaliana	25-28
21573951-4	2012	Positively charged aa such as arginine and lysine encoded by AAR or AGR (CGN) (R means A or G) are seen more frequently in X4 strains suggesting our hypothesis that a switch from R5 to X4 strains occurs via a G-to-A mutation.	Lysine	43-49	cingulin	Homo sapiens	73-76
22122546-3	2012	KYP/SUVH4 is required for histone H3 lysine 9 dimethylation.	Lysine	37-43	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	0-3
22122546-3	2012	KYP/SUVH4 is required for histone H3 lysine 9 dimethylation.	Lysine	37-43	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	4-9
20641774-11	2004	(111)In-Diethylenetriaminepentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 ((111)In-DTPA-Ahx-Lys(40)-exendin-4) is being developed for single-photon emission computed tomography (SPECT) imaging of the GLP-1 receptor (6).	Lysine	62-65	glucagon like peptide 1 receptor	Homo sapiens	206-220
22123821-9	2012	The proposed catalytic mechanism of human UGDH involves Lys(220) as general base for UDP-glucose alcohol oxidation and for oxyanion stabilization during formation and breakdown of the thiohemiacetal and thioester enzyme intermediates.	Lysine	56-59	UDP-glucose 6-dehydrogenase	Homo sapiens	42-46
23132580-2	2012	Here we report that eIF5A2 is reversibly acetylated at lysine-47.	Lysine	55-61	eukaryotic translation initiation factor 5A2	Homo sapiens	20-26
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Lysine	287-293	Tudor staphylococcal nuclease	Drosophila melanogaster	203-207
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Lysine	287-293	l(2)46Cp	Drosophila melanogaster	431-438
22212475-5	2012	During transcription elongation, trimethylation of histone H3 at lysine 36 (H3-K36me3) is mediated by histone methyltransferase Set2, which binds to RNA polymerase II.	Lysine	65-71	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	128-132
21972038-1	2012	The histone methyltransferase (HMT) family of proteins consists of enzymes that methylate lysine or arginine residues on histone tails as well as other proteins.	Lysine	90-96	PR/SET domain 9	Homo sapiens	4-29
21972038-1	2012	The histone methyltransferase (HMT) family of proteins consists of enzymes that methylate lysine or arginine residues on histone tails as well as other proteins.	Lysine	90-96	PR/SET domain 9	Homo sapiens	31-34
22571433-8	2012	Computer modeling suggested enzyme exosite residues 96 (Arg in L-HEP, Lys in L-BEP) and 219 (Lys in L-HEP, Gln in L-BEP) to be responsible for these differences in enteropeptidase catalytic activity.	Lysine	70-73	transmembrane serine protease 15	Homo sapiens	164-179
22571433-8	2012	Computer modeling suggested enzyme exosite residues 96 (Arg in L-HEP, Lys in L-BEP) and 219 (Lys in L-HEP, Gln in L-BEP) to be responsible for these differences in enteropeptidase catalytic activity.	Lysine	93-96	transmembrane serine protease 15	Homo sapiens	164-179
22025676-5	2012	Mutation of lysine 180 of Scs2 abolishes its sumoylation.	Lysine	12-18	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	26-30
22948820-0	2012	Lysine methylation of VCP by a member of a novel human protein methyltransferase family.	Lysine	0-6	valosin containing protein	Homo sapiens	22-25
22844243-2	2012	PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27me3), respectively.	Lysine	132-138	protein regulator of cytokinesis 1	Homo sapiens	0-4
23272056-4	2012	The microscopic measurement of landing and dissociation rates demonstrated the ionic character of the interaction, which could be mapped to a patch of three lysine residues outside of the catalytic domain of human spastin.	Lysine	157-163	spastin	Homo sapiens	214-221
22715377-9	2012	Cells expressing p65(S547A) have a higher level of histone H3 acetylated on Lys(9) at the IL8 promoter, which is in agreement with the higher gene induction observed.	Lysine	76-79	RELA proto-oncogene, NF-kB subunit	Homo sapiens	17-20
22662218-1	2012	BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in cancer cells.	Lysine	212-215	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	136-140
22662218-1	2012	BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in cancer cells.	Lysine	212-215	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	142-177
22662218-1	2012	BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in cancer cells.	Lysine	212-215	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	250-254
22247766-0	2012	Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.	Lysine	4-11	forkhead box P3	Homo sapiens	38-43
22247766-3	2012	We assessed how individual FKH lysines contribute to the functions of Foxp3 in Treg cells.	Lysine	31-38	forkhead box P3	Homo sapiens	70-75
22247766-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: We found that mutation of FKH lysines at position 382 (K17) and at position 393 (K18) impaired Foxp3 DNA binding and inhibited Treg suppressive function in vivo and in vitro.	Lysine	62-69	forkhead box P3	Homo sapiens	127-132
22247766-6	2012	CONCLUSIONS/SIGNIFICANCE: These data point to complex effects of post-translational modifications at individual lysines within the Foxp3 FKH domain that affect Treg function.	Lysine	112-119	forkhead box P3	Homo sapiens	131-136
22004718-4	2011	Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.	Lysine	210-213	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	50-57
22004718-4	2011	Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.	Lysine	210-213	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	221-228
22064703-3	2011	In this study, we demonstrate that, like UHRF1, UHRF2 also binds preferentially to methylated histone H3 lysine 9 (H3K9) through its conserved tudor domain and hemi-methylated DNA through the SET and Ring associated domain.	Lysine	105-111	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	41-46
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	SET and MYND domain containing 3	Homo sapiens	89-92
21563215-8	2011	The sequences and conformations are improved with respect to our previous, polar-hydrogen/CASA study: For several designed complexes, the AspAMP carboxylate forms three interactions with a conserved arginine and a designed lysine, as in the active site of the AspRS:AspAMP complex.	Lysine	223-229	aspartyl-tRNA synthetase 1	Homo sapiens	260-265
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	30-35
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	ZFP36 ring finger protein	Homo sapiens	52-55
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	ZFP36 ring finger protein	Homo sapiens	223-226
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	247-252
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	ZFP36 ring finger protein	Homo sapiens	223-226
21896490-8	2011	In contrast to MHC-II, which has a single, conserved ubiquitin acceptor site in the cytosolic domain, we found that multiple lysine residues in the cytosolic tail of CD86 could support ubiquitination consistent with the relative lack of sequence conservation across species within the CD86 cytosolic domain.	Lysine	125-131	CD86 molecule	Homo sapiens	166-170
21896490-8	2011	In contrast to MHC-II, which has a single, conserved ubiquitin acceptor site in the cytosolic domain, we found that multiple lysine residues in the cytosolic tail of CD86 could support ubiquitination consistent with the relative lack of sequence conservation across species within the CD86 cytosolic domain.	Lysine	125-131	CD86 molecule	Homo sapiens	285-289
21900240-6	2011	Moreover, biochemical assays indicated that the unstructured L4 loop of the MxA stalk serves as the lipid-binding moiety, and mutational analysis of L4 revealed that a stretch of four lysine residues is critical for binding.	Lysine	184-190	MX dynamin like GTPase 1	Homo sapiens	76-79
21516122-0	2011	Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.	Lysine	24-30	PR/SET domain 16	Homo sapiens	15-20
21685499-0	2011	Mass spectrometric identification of novel lysine acetylation sites in huntingtin.	Lysine	43-49	huntingtin	Homo sapiens	71-81
21685499-4	2011	Lysine acetylation of Htt is of particular importance in HD as this modification regulates disease progression and toxicity.	Lysine	0-6	huntingtin	Homo sapiens	22-25
21685499-11	2011	This report represents the first comprehensive mapping of lysine acetylation sites in N-terminal region of Htt.	Lysine	58-64	huntingtin	Homo sapiens	107-110
21868449-6	2011	We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140.	Lysine	142-148	nuclear receptor interacting protein 1	Homo sapiens	38-44
21868449-6	2011	We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140.	Lysine	142-148	nuclear receptor interacting protein 1	Homo sapiens	111-117
21868449-6	2011	We also uncover direct interaction of RIP140 with cyclin-dependent kinase (CDK)8 through the amino terminus of RIP140, which is stimulated by lysine acetylation on RIP140.	Lysine	142-148	nuclear receptor interacting protein 1	Homo sapiens	111-117
21868449-7	2011	We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter.	Lysine	47-53	nuclear receptor interacting protein 1	Homo sapiens	74-80
21868449-7	2011	We further validate the biological activity of lysine acetylation-mimetic RIP140, which elicits a stronger repressive effect and more efficiently recruits CDK8 and confirm CDK8"s function in recruiting repressive components, such as G9a, to the RIP140 complex on this promoter.	Lysine	47-53	nuclear receptor interacting protein 1	Homo sapiens	245-251
21515380-1	2011	Enteropeptidase (synonym: enterokinase, EC 3.4.21.9) is a heterodimeric serine protease of the intestinal brush border that activates trypsinogen by highly specific cleavage of the trypsinogen activation peptide following the sequence (Asp)(4)-Lys.	Lysine	244-247	transmembrane serine protease 15	Homo sapiens	0-15
21515380-5	2011	In this study we have improved the efficiency of fusion proteins cleavage by enteropeptidase by substitution of the Lys residue by Arg in specific cleavage sequence (Asp)(4)-Lys.	Lysine	116-119	transmembrane serine protease 15	Homo sapiens	77-92
21515380-5	2011	In this study we have improved the efficiency of fusion proteins cleavage by enteropeptidase by substitution of the Lys residue by Arg in specific cleavage sequence (Asp)(4)-Lys.	Lysine	174-177	transmembrane serine protease 15	Homo sapiens	77-92
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Lysine	252-255	transmembrane serine protease 15	Bos taurus	94-109
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Lysine	252-255	thioredoxin	Bos taurus	142-145
21219128-7	2011	In quiescent stellate cells and embryonic stem cells, the Nestin expression was suppressed by histone H3 methylation at lysine 9, which is another epigenetic mechanism.	Lysine	120-126	nestin	Rattus norvegicus	58-64
21828050-7	2011	Lys-48-linked but not Lys-63-linked polyubiquitin chain co-localized with KLHL7, which increased upon proteasome inhibition suggesting that KLHL7 mediates protein degradation via UPS.	Lysine	0-3	kelch like family member 7	Homo sapiens	74-79
21828050-7	2011	Lys-48-linked but not Lys-63-linked polyubiquitin chain co-localized with KLHL7, which increased upon proteasome inhibition suggesting that KLHL7 mediates protein degradation via UPS.	Lysine	0-3	kelch like family member 7	Homo sapiens	140-145
21708940-5	2011	siRNA against PP2A catalytic subunit (PP2Ac) or treatment with pharmacological inhibitor, okadaic acid, enhanced IRAK-1 Lys(48)-linked ubiquitination and degradation.	Lysine	120-123	interleukin 1 receptor associated kinase 1	Homo sapiens	113-119
21788502-2	2011	Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation.	Lysine	108-114	lysine (K)-specific demethylase 5A	Mus musculus	0-32
21788502-2	2011	Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation.	Lysine	108-114	lysine (K)-specific demethylase 5A	Mus musculus	34-38
21788502-2	2011	Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation.	Lysine	108-114	lysine (K)-specific demethylase 5A	Mus musculus	52-59
21788502-2	2011	Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation.	Lysine	108-114	lysine (K)-specific demethylase 5A	Mus musculus	63-68
21683083-10	2011	MLL2 and MLL3 play key roles in histone H3 lysine-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in the HOXC6 promoter during E2-dependent transactivation.	Lysine	43-49	lysine methyltransferase 2B	Homo sapiens	0-4
21683083-10	2011	MLL2 and MLL3 play key roles in histone H3 lysine-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in the HOXC6 promoter during E2-dependent transactivation.	Lysine	43-49	lysine methyltransferase 2C	Homo sapiens	9-13
18498648-4	2008	In the present study, we investigated whether Tat could be methylated on lysine residues, specifically on lysine 50 and 51, and whether this modification resulted in a decrease of viral transcription from the LTR.	Lysine	73-79	tyrosine aminotransferase	Homo sapiens	46-49
18498648-4	2008	In the present study, we investigated whether Tat could be methylated on lysine residues, specifically on lysine 50 and 51, and whether this modification resulted in a decrease of viral transcription from the LTR.	Lysine	106-112	tyrosine aminotransferase	Homo sapiens	46-49
18498648-8	2008	In vitro methylation assays with Tat peptides containing point mutations at lysines 50 and 51 showed an increased incorporation of methyl groups on lysine 51, however, both residues indicated susceptibility for methylation.	Lysine	76-83	tyrosine aminotransferase	Homo sapiens	33-36
18498648-8	2008	In vitro methylation assays with Tat peptides containing point mutations at lysines 50 and 51 showed an increased incorporation of methyl groups on lysine 51, however, both residues indicated susceptibility for methylation.	Lysine	76-82	tyrosine aminotransferase	Homo sapiens	33-36
18418072-0	2008	SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail.	Lysine	61-67	lysine methyltransferase 5A	Homo sapiens	0-4
18418072-5	2008	Third, it was evident that the SET8 binds to the H4 N-terminal tail (H4NT) and blocks the acetylation of lysine residues K5, K8 and K12 of histone H4 during G(1).	Lysine	105-111	lysine methyltransferase 5A	Homo sapiens	31-35
18461166-0	2008	Lysine-rich extracellular rings formed by hbeta2 subunits confer the outward rectification of BK channels.	Lysine	0-6	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	42-48
18461166-3	2008	Four consecutive lysines of the hbeta2 extracellular loop, which reside sufficiently close to the extracellular entryway of the pore, constitute three positively charged rings.	Lysine	17-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	32-38
18461166-5	2008	Our results demonstrate that the lysine rings formed by the hbeta2 auxiliary subunits influences the inward current of BK channels, providing a mechanism by which current can be rapidly diminished during cellular repolarization.	Lysine	33-39	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-66
18296440-3	2008	The SET domain proteins PR-Set7 and Suv4-20 have been implicated in mono- and trimethylation, respectively; however, enzymes that dimethylate lysine 20 have not been identified.	Lysine	142-148	PR/SET domain containing protein 7	Drosophila melanogaster	24-31
18029035-4	2008	Ymer, which has been reported to be highly phosphorylated on tyrosine residues via EGF stimulation, bound to lysine (K)-63-linked polyubiquitin chain on receptor-interacting serine/threonine-protein kinase 1 (RIP1), which is essential for NF-kappaB signaling in collaboration with A20.	Lysine	109-115	TNF alpha induced protein 3	Homo sapiens	281-284
18347056-4	2008	We show that trimethylation of histone H3 at lysine 36 (H3K36me3) relies on the histone methyltransferase Hypb and is localized promoter distal at dosage-compensated genes, similar to active genes on autosomes.	Lysine	45-51	SET domain containing 2	Drosophila melanogaster	106-110
18355052-7	2008	Biotinylation of free Ku revealed several reactive lysines on Ku70 and Ku80 which were reduced or eliminated upon DNA binding.	Lysine	51-58	X-ray repair cross complementing 5	Homo sapiens	71-75
18319061-0	2008	Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability.	Lysine	0-6	nucleophosmin 1	Rattus norvegicus	22-25
18307322-6	2008	Sequence alignments of rhuMAb with 12 other recombinant monoclonal antibodies and computer modeling of the Fab part of rhuMAb suggest that the unusually high level of glycation of lysine residue 49, which is located adjacent to the second complementarity-determining region (CDR2) in the light chain, is due to a spatial proximity effect in catalyzing the Amadori rearrangement by aspartic acid residue 31 in the CDR1 on the light chain.	Lysine	180-186	cerebellar degeneration related protein 2	Homo sapiens	275-279
18381416-7	2008	Methylation silencing of rat Tgfbr2 was associated with histone H3 lysine 9 trimethylation, whereas decreased expression of human TGFBR2 was mainly due to decreased transcription activity, sometimes in concert with histone deacetylation and H3 lysine 27 trimethylation.	Lysine	67-73	transforming growth factor, beta receptor 2	Rattus norvegicus	29-35
18034839-3	2008	METHODS: Three types of site-specific (Lys(34)) PEGylated GLP-1 analogues (PEG molecular weight: 1, 2 or 5 kDa) were synthesized.	Lysine	39-42	glucagon	Mus musculus	58-63
18227148-6	2008	The microsomal CYP1B1 protein level was significantly decreased for the Trp(365), Lys(387), and His(390) variants and was not detectable for the Ser(453) variant.	Lysine	82-85	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	15-21
18023379-3	2008	In this paper, molecular modelling studies were undertaken in order to shed light on the molecular basis of interaction between (2S,6S)-diaminopimelic acid (l,l-DAP) (1) with its target enzyme DAP-epimerase, since this is a key step in the lysine biosynthetic path leading to (2R,6S)-diaminopimelic acid (meso-DAP) (2).	Lysine	240-246	death associated protein	Homo sapiens	161-164
18023379-3	2008	In this paper, molecular modelling studies were undertaken in order to shed light on the molecular basis of interaction between (2S,6S)-diaminopimelic acid (l,l-DAP) (1) with its target enzyme DAP-epimerase, since this is a key step in the lysine biosynthetic path leading to (2R,6S)-diaminopimelic acid (meso-DAP) (2).	Lysine	240-246	death associated protein	Homo sapiens	193-196
18023379-3	2008	In this paper, molecular modelling studies were undertaken in order to shed light on the molecular basis of interaction between (2S,6S)-diaminopimelic acid (l,l-DAP) (1) with its target enzyme DAP-epimerase, since this is a key step in the lysine biosynthetic path leading to (2R,6S)-diaminopimelic acid (meso-DAP) (2).	Lysine	240-246	death associated protein	Homo sapiens	193-196
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Lysine	235-241	lysine acetyltransferase 2B	Homo sapiens	36-41
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	lysine acetyltransferase 2B	Homo sapiens	153-179
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	lysine acetyltransferase 2B	Homo sapiens	181-185
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	lysine acetyltransferase 2B	Homo sapiens	153-179
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	lysine acetyltransferase 2B	Homo sapiens	181-185
18082865-6	2008	N-terminal lysine residues were shown to play a critical role in the Vif- and Vpr-mediated degradation of IRF-3.	Lysine	11-17	Vpr	Human immunodeficiency virus 1	78-81
18082865-6	2008	N-terminal lysine residues were shown to play a critical role in the Vif- and Vpr-mediated degradation of IRF-3.	Lysine	11-17	interferon regulatory factor 3	Homo sapiens	106-111
18031291-6	2008	OXA-1 shares with other class D enzymes a carboxylated residue, Lys(70), that acts as a general base in the catalytic mechanism.	Lysine	64-67	beta-lactamase OXA-1 precursor	Escherichia coli	0-5
18031291-8	2008	Because Asp(66) forms hydrogen bonds with several other residues in the OXA-1 active site, we propose that this residue plays a role in stabilizing the CO2 bound to Lys(70) and thereby profoundly affects substrate turnover.	Lysine	165-168	beta-lactamase OXA-1 precursor	Escherichia coli	72-77
18020317-2	2008	The RXR-SRC1 interactions in three types of RXR-9cRA-SRC1 complexes, namely, a wild type (WT), a mutant whose Glu453 of AF2C was substituted by Lys (E453K), and another mutant whose Glu456 of AF2C was substituted by Lys (E456K), were compared.	Lysine	144-147	nuclear receptor coactivator 1	Homo sapiens	8-12
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	DNA helicase RAD5	Saccharomyces cerevisiae S288C	17-21
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	DNA helicase RAD5	Saccharomyces cerevisiae S288C	17-21
18296633-5	2008	Using MyoD and Id1 mutants deficient in either N terminus-dependent or internal lysine-dependent ubiquitination, we further show that these ubiquitination pathways of MyoD degradation are regulated differently from those of Id1 degradation.	Lysine	80-86	inhibitor of DNA binding 1, HLH protein	Homo sapiens	15-18
17998425-2	2008	Cationic AA transporter-1 (CAT-1) is a major intestinal CAA transporter, demonstrating a high-affinity (muM) transport activity for l-Lys in other mammals, and is widely expressed by small intestinal epithelia of nonruminants, but neither sequence nor expression pattern data exist for CAT-1 in cattle.	Lysine	132-137	solute carrier family 7 member 1	Bos taurus	27-32
17998425-2	2008	Cationic AA transporter-1 (CAT-1) is a major intestinal CAA transporter, demonstrating a high-affinity (muM) transport activity for l-Lys in other mammals, and is widely expressed by small intestinal epithelia of nonruminants, but neither sequence nor expression pattern data exist for CAT-1 in cattle.	Lysine	132-137	solute carrier family 7 member 1	Bos taurus	286-291
17998425-14	2008	These data indicate that previously reported Na(+)-independent uptake of Lys by jejunal and ileal epithelia likely occurred by CAT-1, and that the potential capacity for CAT-1-mediated uptake of CAA for beef steers may be greatest for the "growing" phenotype.	Lysine	73-76	solute carrier family 7 member 1	Bos taurus	127-132
18263619-0	2008	Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.	Lysine	44-50	E1A binding protein p300	Homo sapiens	30-34
18263619-0	2008	Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.	Lysine	44-50	RELA proto-oncogene, NF-kB subunit	Homo sapiens	78-82
18263619-0	2008	Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.	Lysine	44-50	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
18263619-2	2008	We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylation sites.	Lysine	69-75	RELA proto-oncogene, NF-kB subunit	Homo sapiens	49-53
18263619-2	2008	We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylation sites.	Lysine	69-75	RELA proto-oncogene, NF-kB subunit	Homo sapiens	54-57
18263619-2	2008	We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylation sites.	Lysine	69-75	E1A binding protein p300	Homo sapiens	61-65
18093968-5	2008	Two SecS monomers interact intimately and together build up two identical active sites around PLP in a Schiff-base linkage with lysine 284.	Lysine	128-134	pyridoxal phosphatase	Homo sapiens	94-97
18096514-3	2008	Domain analysis and site-directed substitution of neddylation sites showed that multiple lysine residues of the APP C-terminal C99 fragment including AICD were acceptor sequences for Nedd8 conjugation.	Lysine	89-95	NEDD8 ubiquitin like modifier	Homo sapiens	183-188
17990982-9	2008	The UIM of TRAC-1 binds Lys(48)-linked polyubiquitin chains and is, together with the RING domain, required for auto-ubiquitination.	Lysine	24-27	ring finger protein 125	Homo sapiens	11-17
18280244-6	2008	We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60.	Lysine	57-63	SET domain containing (lysine methyltransferase) 7	Mus musculus	86-92
18280244-6	2008	We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60.	Lysine	57-63	K(lysine) acetyltransferase 5	Mus musculus	215-220
18230726-5	2008	Down-regulation of both MICA and AICL requires the ubiquitin E3 ligase activity of K5 to target substrate cytoplasmic tail lysine residues.	Lysine	123-129	MHC class I polypeptide-related sequence A	Homo sapiens	24-28
18344599-7	2008	Pirh2 preferentially utilized lysine residues 6 and 29 of the ubiquitin to mediate the formation of polyubiquitin chains on SRbeta.	Lysine	30-36	ring finger and CHY zinc finger domain containing 1	Homo sapiens	0-5
18006692-10	2008	His107 (EC2-BRS-3) for lysine (H107K) (EC2-GRPR) decreased affinity (25- and 0-fold) for peptides 4 and 1; however, it could not be activated by either peptide.	Lysine	23-29	bombesin receptor subtype 3	Homo sapiens	12-17
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	42-48	nucleotide binding oligomerization domain containing 2	Homo sapiens	143-147
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	83-89	nucleotide binding oligomerization domain containing 2	Homo sapiens	143-147
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Lysine	114-117	melanocortin 3 receptor	Homo sapiens	315-320
20641499-15	2004	(11) showed that the kidney uptake of a short linear DOTA-alpha-MSH analog (DOTA-NAPamide) could be considerably reduced by neutralizing the charge of the Lys(11) residue.	Lysine	155-158	pro-opiomelanocortin-alpha	Mus musculus	58-67
17998205-4	2008	Both Siah1 and Siah2 interacted with the RA2 domain of PLCepsilon, and the mutation of Lys-2186 of the PLCepsilon RA2 domain abolished this association.	Lysine	87-90	phospholipase C, epsilon 1	Mus musculus	55-65
17998205-4	2008	Both Siah1 and Siah2 interacted with the RA2 domain of PLCepsilon, and the mutation of Lys-2186 of the PLCepsilon RA2 domain abolished this association.	Lysine	87-90	phospholipase C, epsilon 1	Mus musculus	103-113
18158948-4	2008	We have coupled the alpha-MSH analog Ac-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2), through the epsilon-amino group of Lys(11), to a pyrazolyl-containing chelator (pz).	Lysine	70-73	pro-opiomelanocortin-alpha	Mus musculus	20-29
18852898-3	2008	In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci.	Lysine	94-100	SET domain-containing protein	Arabidopsis thaliana	13-16
18852898-3	2008	In addition, CLF directly interacts with and mediates the deposition of repressive histone H3 lysine 27 trimethylation (H3K27me3) into FLC and FLC relatives, which suppresses active histone H3 lysine 4 trimethylation (H3K4me3) in these loci.	Lysine	193-199	SET domain-containing protein	Arabidopsis thaliana	13-16
18158331-0	2007	PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.	Lysine	18-24	lysine methyltransferase 5A	Homo sapiens	0-7
18158331-8	2007	Collectively, these data indicate that PR-Set7-dependent lysine methylation during S phase is an essential posttranslational mechanism that ensures genome replication and stability.	Lysine	57-63	lysine methyltransferase 5A	Homo sapiens	39-46
17963691-4	2007	When several lysine residues in the MSP domain were substituted for alanine, the resulting mutant Scs2 proteins lost the phosphoinositide-binding ability and failed to complement the inositol auxotrophy of an scs2 deletion strain.	Lysine	13-19	phosphatidylinositol-binding protein SCS2	Saccharomyces cerevisiae S288C	98-102
17590163-6	2007	M. avium-induced MMP-9 gene induction requires the histone acetyltransferase p300 and chromatin modifications involving phosphorylation of p65 at serine 276 and its acetylation at lysines 221 and 310.	Lysine	180-187	matrix metallopeptidase 9	Mus musculus	17-22
17590163-7	2007	At the same time, histone H3 modified by mitogen and stress-activated protein kinase 1 (MSK1)-dependent phosphorylation on serine 10 and by acetylation on lysine 14, typical signatures linked to transcriptional activation, also associates with the MMP-9 promoter following M. avium challenge.	Lysine	155-161	matrix metallopeptidase 9	Mus musculus	248-253
17761950-3	2007	Here, we provide the first evidence of RXRalpha acetylation by p300 on lysine 145.	Lysine	71-77	E1A binding protein p300	Homo sapiens	63-67
17884818-5	2007	An in vivo acetylation assay using 293T cells revealed that Fli1 is mainly acetylated by the histone acetyltransferase activity of p300/CBP-associated factor (PCAF) at lysine 380.	Lysine	168-174	lysine acetyltransferase 2B	Homo sapiens	131-157
17884818-5	2007	An in vivo acetylation assay using 293T cells revealed that Fli1 is mainly acetylated by the histone acetyltransferase activity of p300/CBP-associated factor (PCAF) at lysine 380.	Lysine	168-174	lysine acetyltransferase 2B	Homo sapiens	159-163
17884818-11	2007	These results indicate that PCAF-dependent acetylation of lysine 380 abrogates repressor function of Fli1 with respect to collagen gene expression.	Lysine	58-64	lysine acetyltransferase 2B	Homo sapiens	28-32
17963781-3	2007	Here we report that the alpha-NH(2) group of the N terminus and the epsilon-NH(2) groups of internal lysine residues 116, 118 and 269 (K116, K118 and K269) of Smad1 are ubiquitin acceptor sites mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP).	Lysine	101-107	SMAD family member 1	Homo sapiens	159-164
18006819-0	2007	The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.	Lysine	4-10	SET and MYND domain containing 3	Homo sapiens	100-105
17767917-1	2007	We investigated the encapsulation of BMP-2 gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of bone morphogenic protein-2 (BMP-2) to induce bone formation.	Lysine	99-112	bone morphogenetic protein 2	Homo sapiens	37-42
17767917-1	2007	We investigated the encapsulation of BMP-2 gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of bone morphogenic protein-2 (BMP-2) to induce bone formation.	Lysine	99-112	bone morphogenetic protein 2	Homo sapiens	164-190
17922010-4	2007	Optimal T(reg) function required acetylation of several lysines in the forkhead domain of Foxp3, and Foxp3 acetylation enhanced binding of Foxp3 to the Il2 promoter and suppressed endogenous IL-2 production.	Lysine	56-63	forkhead box P3	Homo sapiens	90-95
17924656-9	2007	We demonstrate that ActRIIbE76K and ActRII bind BMP-3 with similar affinity, indicating BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb.	Lysine	151-154	bone morphogenetic protein 3	Homo sapiens	88-93
17924656-9	2007	We demonstrate that ActRIIbE76K and ActRII bind BMP-3 with similar affinity, indicating BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb.	Lysine	151-154	bone morphogenetic protein 3	Homo sapiens	88-93
17706596-5	2007	Histone H3 lysine 9 trimethylation level and deposition of HP1beta increased in RhoB promoter during aging, whereas histone H3 lysine 4 dimethylation level gradually decreased.	Lysine	11-17	ras homolog family member B	Mus musculus	80-84
17604279-3	2007	To identify common structures in S5 and S6 that govern interaction with the pore, we created a chimera in which the S5-pore-S6 region of TRPM8 was inserted into TRPM2, along with a lysine at each transition site.	Lysine	181-187	transient receptor potential cation channel subfamily M member 8	Homo sapiens	137-142
17803944-3	2007	Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --&gt; lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3.	Lysine	110-116	putative DNA/RNA helicase SEN1	Saccharomyces cerevisiae S288C	210-214
17803944-3	2007	Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --&gt; lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3.	Lysine	110-116	hydroxymethylbilane synthase	Saccharomyces cerevisiae S288C	220-224
17658645-1	2007	Transglutaminase (TGase) catalyzes the formation of a covalent cross-link between a peptide-bound glutamine residue and a lysine residue or primary amine.	Lysine	122-128	coagulation factor XIII B chain	Homo sapiens	0-16
17658645-1	2007	Transglutaminase (TGase) catalyzes the formation of a covalent cross-link between a peptide-bound glutamine residue and a lysine residue or primary amine.	Lysine	122-128	coagulation factor XIII B chain	Homo sapiens	18-23
17707234-0	2007	Modulation of p53 function by SET8-mediated methylation at lysine 382.	Lysine	59-65	lysine methyltransferase 5A	Homo sapiens	30-34
17707234-4	2007	We find that SET8 specifically monomethylates p53 at lysine 382 (p53K382me1).	Lysine	53-59	lysine methyltransferase 5A	Homo sapiens	13-17
17544230-0	2007	Trithorax-group protein ASH1 methylates histone H3 lysine 36.	Lysine	51-57	ASH1 like histone lysine methyltransferase	Homo sapiens	24-28
17544230-5	2007	The assay reproduced specificities of previously known histone methyltransferases and further revealed unexpectedly that mammalian ASH1 mono- or di-methylates histone H3 K36 but not any other lysine residues of recombinant unmodified mammalian histones.	Lysine	192-198	ASH1 like histone lysine methyltransferase	Homo sapiens	131-135
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Lysine	123-129	immunoglobulin heavy locus	Homo sapiens	17-20
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Lysine	123-129	CDR3	Homo sapiens	21-25
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Lysine	123-129	glucose-6-phosphate isomerase	Homo sapiens	34-37
17503466-3	2007	The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a conserved lysine residue with a serine.	Lysine	119-125	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	15-18
17663752-6	2007	These results indicate that lysines 67 and 313 and arginine 295 play a critical role in forming the proper three-dimensional structure of P2X(4)R for agonist binding and/or channel gating.	Lysine	28-35	purinergic receptor P2X 4	Homo sapiens	138-145
17525156-4	2007	Biochemical analysis and chromatin immunoprecipitation experiments indicate that Rph1 functions as a specific demethylase for H3 K36me3 and K36me2, directly regulating Lys(36) methylation in transcribed regions.	Lysine	168-171	Rph1p	Saccharomyces cerevisiae S288C	81-85
17582821-3	2007	In this report, we determined the structure of the bromodomain from human brahma-related gene 1 (BRG1) protein, a subunit of an ATP-dependent switching/sucrose nonfermenting (SWI/SNF) remodeling complex, and have also characterized its in vitro interaction with N-acetylated lysine peptides from histones.	Lysine	275-281	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	74-95
17582821-3	2007	In this report, we determined the structure of the bromodomain from human brahma-related gene 1 (BRG1) protein, a subunit of an ATP-dependent switching/sucrose nonfermenting (SWI/SNF) remodeling complex, and have also characterized its in vitro interaction with N-acetylated lysine peptides from histones.	Lysine	275-281	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	97-101
17582821-7	2007	By modeling the acetylated-lysine peptide into the BRG1 bromodomain structure, we were able to explain the weak binding of acetylated-lysine peptides to this bromodomain.	Lysine	27-33	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	51-55
17582821-7	2007	By modeling the acetylated-lysine peptide into the BRG1 bromodomain structure, we were able to explain the weak binding of acetylated-lysine peptides to this bromodomain.	Lysine	134-140	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	51-55
17590016-1	2007	The transcriptional coactivator paralogues p300 and CBP contain acetyltransferase domains (HAT) and catalyze the lysine acetylation of histones and other proteins as an important aspect of their functions.	Lysine	113-119	E1A binding protein p300	Homo sapiens	43-47
17590016-8	2007	Using mass spectrometry, two p300 HAT lysine acetylation sites were mapped in ATF-2 b-ZIP.	Lysine	38-44	E1A binding protein p300	Homo sapiens	29-37
21794016-5	2011	Low concentration of lysine suppressed lipid accumulation and messenger RNA (mRNA) expression and enzyme activity of fatty acid synthase.	Lysine	21-27	fatty acid synthase	Sus scrofa	117-136
21746811-3	2011	In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (Smu) bearing H3K9me3 (trimethylated histone H3 at lysine 9) in vivo.	Lysine	236-242	activation induced cytidine deaminase	Homo sapiens	40-43
21904977-1	2011	The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans).	Lysine	68-74	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	31-35
21904977-1	2011	The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans).	Lysine	68-74	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	117-121
22021773-1	2011	OBJECTIVES: To determine whether polymorphisms at codon 487 (*1, GAA=Glu; *2, AAA=Lys) of mitochondrial aldehyde dehydrogenase 2 (ALDH2) influence nitroglycerine (glyceryl trinitrate (GTN))-induced vasodilation, and whether GTN or isosorbide dinitrate (ISDN) is a more effective antianginal agent in each ALDH2 genotype.	Lysine	82-85	aldehyde dehydrogenase 2 family member	Homo sapiens	130-135
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	92-95	huntingtin	Homo sapiens	59-62
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	100-103	huntingtin	Homo sapiens	59-62
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	69-72	Fc epsilon receptor II	Homo sapiens	4-8
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	69-72	ADAM metallopeptidase domain 10	Homo sapiens	149-155
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	100-103	huntingtin	Homo sapiens	59-62
24879150-6	2014	We report that UCHL1 dysfunction aggravated the hIAPP-induced defect in the autophagy/lysosomal pathway, illustrated by the marked accumulation of autophagosomes and cytoplasmic inclusions positive for SQSTM1/p62 and polyubiquitinated proteins with lysine 63-specific ubiquitin chains.	Lysine	249-255	islet amyloid polypeptide	Homo sapiens	48-53
21454471-8	2011	Mutant N-HTT inclusions are enriched for ubiquitin staining only when TRAF6 and Lys(6), Lys(27), and Lys(29) ubiquitin mutants are expressed.	Lysine	80-83	huntingtin	Homo sapiens	9-12
21454471-8	2011	Mutant N-HTT inclusions are enriched for ubiquitin staining only when TRAF6 and Lys(6), Lys(27), and Lys(29) ubiquitin mutants are expressed.	Lysine	88-91	huntingtin	Homo sapiens	9-12
21454471-8	2011	Mutant N-HTT inclusions are enriched for ubiquitin staining only when TRAF6 and Lys(6), Lys(27), and Lys(29) ubiquitin mutants are expressed.	Lysine	88-91	huntingtin	Homo sapiens	9-12
21543325-0	2011	Contribution of conserved lysine residues in the alpha2-antiplasmin C terminus to plasmin binding and inhibition.	Lysine	26-32	plasminogen	Homo sapiens	60-67
17634552-13	2007	DAC treatment increased H3 Lys(9) acetylation of Alu elements, whereas ara-C had no effect, and the addition of ara-C to DAC inhibited this effect.	Lysine	27-30	arylacetamide deacetylase	Homo sapiens	0-3
17517885-11	2007	Because this mutated residue is an exposed lysine in the Aah1p three-dimensional model, we propose that it is likely to be a major ubiquitylation site.	Lysine	43-49	adenine deaminase	Saccharomyces cerevisiae S288C	57-62
24393343-3	2014	Here, we investigated the function of CURLY LEAF (CLF), a Polycomb-group (PcG) gene responsible for histone3 lysine 27 trimethylation (H3K27me3), in somatic and meiotic HR in Arabidopsis thaliana.	Lysine	109-115	SET domain-containing protein	Arabidopsis thaliana	38-48
17524524-0	2007	Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity.	Lysine	32-38	fibroblast growth factor 2	Rattus norvegicus	0-30
17524524-3	2007	Binding to heparin-acrylic beads was markedly reduced when lysine in position 134 of bFGF was replaced by alanine.	Lysine	59-65	fibroblast growth factor 2	Rattus norvegicus	85-89
21543325-4	2011	We determined that the C-terminal lysine (Lys-464) is individually most important in initiating binding to plasmin.	Lysine	34-40	plasminogen	Homo sapiens	107-114
21543325-4	2011	We determined that the C-terminal lysine (Lys-464) is individually most important in initiating binding to plasmin.	Lysine	42-45	plasminogen	Homo sapiens	107-114
21543325-5	2011	Using two independent methods, we also showed that the conserved internal lysine residues play a major role mediating binding of the C terminus of alpha(2)-antiplasmin to kringle domains of plasmin and in accelerating the rate of interaction between alpha(2)-antiplasmin and plasmin.	Lysine	74-80	plasminogen	Homo sapiens	160-167
17524524-7	2007	In conclusion, lysine at position 134 of bFGF is essential for bFGF to bind heparin, then to interact with its receptor and, subsequently, to protect neurons against damage.	Lysine	15-21	fibroblast growth factor 2	Rattus norvegicus	41-45
17524524-7	2007	In conclusion, lysine at position 134 of bFGF is essential for bFGF to bind heparin, then to interact with its receptor and, subsequently, to protect neurons against damage.	Lysine	15-21	fibroblast growth factor 2	Rattus norvegicus	63-67
21543325-5	2011	Using two independent methods, we also showed that the conserved internal lysine residues play a major role mediating binding of the C terminus of alpha(2)-antiplasmin to kringle domains of plasmin and in accelerating the rate of interaction between alpha(2)-antiplasmin and plasmin.	Lysine	74-80	plasminogen	Homo sapiens	190-197
24393343-3	2014	Here, we investigated the function of CURLY LEAF (CLF), a Polycomb-group (PcG) gene responsible for histone3 lysine 27 trimethylation (H3K27me3), in somatic and meiotic HR in Arabidopsis thaliana.	Lysine	109-115	SET domain-containing protein	Arabidopsis thaliana	50-53
24702180-5	2014	Further, the mutually exclusive interactions of MYST1 with sirtuin 1 vs AR regulate the acetylation of lysine 16 on histone H4.	Lysine	103-109	lysine acetyltransferase 8	Homo sapiens	48-53
21443952-5	2011	These comprehensive analyses have revealed (i) that RAD6 serves as the cognate E2 for the BRE1 complex in human cells, as previously established in yeast, (ii) that RAD6, through direct interaction with the BRE1 complex, ubiquitylates chromatinized H2B at lysine 120 and (iii) that PAF1 complex-mediated transcription is required for efficient H2B ubiquitylation.	Lysine	256-262	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	207-211
17498659-5	2007	We find that BRD7 bromodomain contains the typical left-handed four-helix bundle topology, and can bind with weak affinity to lysine-acetylated peptides derived from histone H3 with K9 or K14 acetylated and from histone H4 with K8, K12 or K16 acetylated.	Lysine	126-132	keratin 12	Homo sapiens	232-235
17498659-5	2007	We find that BRD7 bromodomain contains the typical left-handed four-helix bundle topology, and can bind with weak affinity to lysine-acetylated peptides derived from histone H3 with K9 or K14 acetylated and from histone H4 with K8, K12 or K16 acetylated.	Lysine	126-132	keratin 16	Homo sapiens	239-242
21764993-3	2011	RPN10 and members of the UBL-UBA-containing RAD23 and DSK2 families displayed strong affinities for Lys-48-linked ubiquitin chains (the major UPP signals), indicating that they are involved in ubiquitylated substrate recognition.	Lysine	100-103	Rad23 UV excision repair protein family	Arabidopsis thaliana	44-49
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Lysine	21-24	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
21764993-3	2011	RPN10 and members of the UBL-UBA-containing RAD23 and DSK2 families displayed strong affinities for Lys-48-linked ubiquitin chains (the major UPP signals), indicating that they are involved in ubiquitylated substrate recognition.	Lysine	100-103	ubiquitin family protein	Arabidopsis thaliana	54-58
21351738-8	2011	Mutation of the Arg residue to Ala in the Drosophila Polyhomeotic (Ph) protein, which is equivalent to Lys 816 in HPH1, was unable to repress transcription of a reporter gene to the level of wild-type Ph.	Lysine	103-106	polyhomeotic distal	Drosophila melanogaster	67-69
17434681-8	2007	Pretreatment of the LPBN with the 5-HT3 receptor antagonist, 1-methyl-N-[8-methyl-8-azabicyclo (3.2.1)-oct-3-yl]-1H-indazole-3-carboxamide (LY-278,584) abolished the effects of PBG, but LY-278,584 had no effects on sodium or water intake when injected by itself.	Lysine	140-142	5-hydroxytryptamine receptor 3A	Rattus norvegicus	34-48
17434681-8	2007	Pretreatment of the LPBN with the 5-HT3 receptor antagonist, 1-methyl-N-[8-methyl-8-azabicyclo (3.2.1)-oct-3-yl]-1H-indazole-3-carboxamide (LY-278,584) abolished the effects of PBG, but LY-278,584 had no effects on sodium or water intake when injected by itself.	Lysine	186-188	5-hydroxytryptamine receptor 3A	Rattus norvegicus	34-48
24556617-0	2014	Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.	Lysine	65-71	prominin 1	Homo sapiens	33-38
17540172-4	2007	Consistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.	Lysine	138-144	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	40-47
17540172-4	2007	Consistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.	Lysine	167-173	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	40-47
21467042-0	2011	Kinetics of activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-catalyzed cleavage of C-terminal lysine residues of fibrin degradation products and removal of plasminogen-binding sites.	Lysine	107-113	carboxypeptidase B2	Homo sapiens	22-65
17545996-4	2007	Furthermore, lysine acetylation occurs in cellular structure proteins such as alpha-tubulin, actin, cortactin and p120 catenin.	Lysine	13-19	catenin delta 1	Homo sapiens	114-126
24556617-0	2014	Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.	Lysine	65-71	N-acetyltransferase 8B (putative, gene/pseudogene)	Homo sapiens	42-48
21532592-4	2011	Here we show that, unlike many E2s that transfer Ub with RINGs, UBCH7 lacks intrinsic, E3-independent reactivity with lysine, explaining its preference for HECTs.	Lysine	118-124	ubiquitin conjugating enzyme E2 L3	Homo sapiens	64-69
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	N-acetyltransferase 8B (putative, gene/pseudogene)	Homo sapiens	101-107
21532592-5	2011	Despite lacking lysine reactivity, UBCH7 exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes parkin (also known as PARK2) and human homologue of ariadne (HHARI; also known as ARIH1).	Lysine	16-22	ubiquitin conjugating enzyme E2 L3	Homo sapiens	35-40
17482720-5	2007	Additionally, we have discovered an interesting new selective antagonist at the hMC3R, Ac-Nle-c[Asp-betaAla-DNal(2")-Arg-Trp-Lys]-NH(2) (2, PG-106) which represents an important tool in further biological investigations of the hMC3R.	Lysine	125-128	melanocortin 3 receptor	Homo sapiens	80-85
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	N-acetyltransferase 8B (putative, gene/pseudogene)	Homo sapiens	109-114
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	prominin 1	Homo sapiens	164-169
24556617-2	2014	We report that the endoplasmic reticulum Golgi intermediate compartment residing acetyltransferases, ATase1 (NAT8B) and ATase2 (NAT8), can physically interact with CD133 to acetylate the protein on three lysine residues predicted to reside on the first extracellular loop of CD133.	Lysine	204-210	prominin 1	Homo sapiens	275-280
17499824-4	2007	The deduced amino acid sequence showed significant identity to plant and mammalian serine racemases and contained conserved pyridoxal 5-phosphate (PLP)-binding lysine and PLP-interacting amino acid residues.	Lysine	160-166	pyridoxal phosphatase	Homo sapiens	147-150
21397007-1	2011	Yeast lacking copper-zinc superoxide dismutase (sod1 ) have a number of oxygen-dependent defects, including auxotrophies for lysine and methionine and sensitivity to oxygen.	Lysine	125-131	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	48-52
24556617-5	2014	Taken together, we suggest that lysine acetylation on predicted extracellular residues plays a key role in expression and trafficking of CD133 protein to the cell surface and can be targeted to disrupt CD133 regulation and function.	Lysine	32-38	prominin 1	Homo sapiens	137-142
24556617-5	2014	Taken together, we suggest that lysine acetylation on predicted extracellular residues plays a key role in expression and trafficking of CD133 protein to the cell surface and can be targeted to disrupt CD133 regulation and function.	Lysine	32-38	prominin 1	Homo sapiens	202-207
24568369-1	2014	Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research.	Lysine	119-125	delta/notch like EGF repeat containing	Homo sapiens	47-50
21460220-4	2011	We determined that the increase in mass of yeast Rpl1ab is consistent with the addition of a methyl group to lysine 46 using top-down mass spectrometry.	Lysine	109-115	ribosomal 60S subunit protein L5	Saccharomyces cerevisiae S288C	49-53
21460220-5	2011	Lysine modification was confirmed by detecting (3)H-N-epsilon-monomethyllysine in hydrolysates of Rpl1ab purified from yeast cells radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.	Lysine	0-6	ribosomal 60S subunit protein L5	Saccharomyces cerevisiae S288C	98-102
21596310-5	2011	L3MBTL2-specific RNAi resulted in increased expression of target genes that exhibited a significant reduction in H2A lysine 119 monoubiquitination.	Lysine	117-123	H2A clustered histone 18	Homo sapiens	113-116
17400223-5	2007	Low Lys intake decreased the nitrogen deposition and muscle protein accretion in fish and significantly down-regulated hepatic IGFBP-1 as well as muscle GH-R and IGF-II, as compared to those fed the ML diet.	Lysine	4-7	insulin-like growth factor 2b	Salmo salar	162-168
17400223-7	2007	High Lys intake resulted in a 7-fold up-regulation of muscle IGF-II mRNA level as compared to low Lys intake, and thus might be an important local anabolic regulator in fast muscle tissue.	Lysine	5-8	insulin-like growth factor 2b	Salmo salar	61-67
17400223-8	2007	The single indispensable amino acid Lys indeed affected signalling through the genes of IGF-I, IGFBP-1 in hepatic tissue and GH-R, IGF-II in fast muscle in Atlantic salmon.	Lysine	36-39	insulin-like growth factor 2b	Salmo salar	131-137
21402701-5	2011	Zymosan also induced the interaction of Hes1 and TLE with histone H3 phosphorylated on Ser-10 and deacetylated on Lys-14.	Lysine	114-117	hes family bHLH transcription factor 1	Homo sapiens	40-44
24733848-3	2014	The bromodomain and extraterminal (BET) proteins, Brd2, Brd3, Brd4, and BrdT, bind to acetylated lysine residues on histone or nonhistone proteins recruiting transcriptional regulators and thus activating or repressing gene transcription.	Lysine	97-103	delta/notch like EGF repeat containing	Homo sapiens	35-38
21454709-0	2011	The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.	Lysine	83-89	E1A binding protein p300	Homo sapiens	58-62
24778210-4	2014	Here we report the identification and characterization of lysine-specific histone demethylase 5B (KDM5B), a member of the JmjC domain-containing histone demethylases, as an important player in multiple aspects of DNA double-strand break (DSB) response in human cells.	Lysine	58-64	lysine demethylase 5B	Homo sapiens	98-103
21367748-3	2011	EZH2, together with SUZ12 and EED, forms the polycomb repressive complex 2 (PRC2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	128-134	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	20-25
17429947-4	2007	High-performance liquid chromatography, mass spectrometry, and proteolysis of KA-modified apoC-II revealed that KA randomly modified six different lysine residues, with primarily one KA attached per apoC-II molecule.	Lysine	147-153	apolipoprotein C2	Homo sapiens	90-97
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Lysine	36-39	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	60-64
17254749-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	NEDD8 ubiquitin like modifier	Homo sapiens	153-158
21383063-5	2011	BMI1 is required for DNA damage-induced ubiquitination of histone H2A at lysine 119.	Lysine	73-79	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	0-4
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Lysine	36-39	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	160-164
25254151-2	2014	Epigenetic marks have pivotal roles in the maintenance of gene expression status, as occurs with methylation on lysine 27 of histone H3 (H3K27me) for Hox gene regulation.	Lysine	112-118	Histone H3.3 type 2	Caenorhabditis elegans	125-132
21291937-6	2011	Although the lack of C-terminal two amino acids did not modify PK profile and GH releasing activity, the deletion of C-terminal 8 and 20 amino acids affected them, and ghrelin(1-7)-Lys-NH(2) exhibited very short plasma half-life and low GH releasing activity in vivo.	Lysine	181-184	ghrelin and obestatin prepropeptide	Rattus norvegicus	168-175
21291937-7	2011	In rat plasma, ghrelin(1-7)-Lys-NH(2) was degraded more rapidly than ghrelin, suggesting that C-terminal part of ghrelin protected octanoylation of Ser(3) from plasma esterases.	Lysine	28-31	ghrelin and obestatin prepropeptide	Rattus norvegicus	15-22
17344218-5	2007	Others have previously reported that Vps75 forms a complex with Rtt109, required for acetylation of histone H3 lysine 56 (H3 Lys-56).	Lysine	111-117	Vps75p	Saccharomyces cerevisiae S288C	37-42
17344218-5	2007	Others have previously reported that Vps75 forms a complex with Rtt109, required for acetylation of histone H3 lysine 56 (H3 Lys-56).	Lysine	125-128	Vps75p	Saccharomyces cerevisiae S288C	37-42
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	35-41	suppressor of cytokine signaling 3	Homo sapiens	193-198
25254151-6	2014	This mechanism represses transcription of selector genes in the genomic region where lysine 27 of histone H3 (H3K27) is demethylated by histone demethylase UTX-1.	Lysine	85-91	Histone H3.3 type 2	Caenorhabditis elegans	98-105
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	251-257	suppressor of cytokine signaling 3	Homo sapiens	193-198
25254151-6	2014	This mechanism represses transcription of selector genes in the genomic region where lysine 27 of histone H3 (H3K27) is demethylated by histone demethylase UTX-1.	Lysine	85-91	Histone H3.3 type 2	Caenorhabditis elegans	136-143
24528089-8	2014	In summary, the global hypoacetylation of histone H3 and H4 and the hypertrimethylation of histone H4 lysine 20 account for epigenetic characteristics in senescence, controlled by HATs, HMT, and HDACs differentially between replicative and premature senescence.	Lysine	102-108	PR/SET domain 9	Homo sapiens	186-189
17965588-3	2007	Here we show that the Arabidopsis homolog of Trithorax, ATX1, activates the expression of the WRKY70 gene and is involved in establishing the trimethylation pattern of histone H3 tail lysine 4 (H3K4me3) residues of its nucleosomes.	Lysine	184-190	homolog of anti-oxidant 1	Arabidopsis thaliana	56-60
21357426-5	2011	Moreover, p300 interacts with the C terminus of Pax5 and acetylates multiple lysine residues within the paired box DNA binding domain of Pax5.	Lysine	77-83	E1A binding protein p300	Homo sapiens	10-14
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	E1A binding protein p300	Homo sapiens	73-77
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	CD19 molecule	Homo sapiens	119-123
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	CD19 molecule	Homo sapiens	200-204
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	B cell linker	Homo sapiens	209-213
24667637-4	2014	G9A-mediated dimethylation of histone H3 lysine 9 (H3K9me2) restricted Th17 and Treg differentiation in vitro and in vivo.	Lysine	41-47	euchromatic histone lysine N-methyltransferase 2	Mus musculus	0-3
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-208	clock circadian regulator	Homo sapiens	68-73
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-208	clock circadian regulator	Homo sapiens	110-115
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-207	clock circadian regulator	Homo sapiens	68-73
21146585-2	2011	We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity.	Lysine	201-207	clock circadian regulator	Homo sapiens	110-115
17283062-7	2007	In addition, deletion of RKR1 causes severe genetic interactions with mutations that prevent histone H2B lysine 123 ubiquitylation or histone H3 lysine 4 methylation.	Lysine	105-111	ubiquitin-protein ligase RKR1	Saccharomyces cerevisiae S288C	25-29
17283062-7	2007	In addition, deletion of RKR1 causes severe genetic interactions with mutations that prevent histone H2B lysine 123 ubiquitylation or histone H3 lysine 4 methylation.	Lysine	145-151	ubiquitin-protein ligase RKR1	Saccharomyces cerevisiae S288C	25-29
17468264-6	2007	Perturbation of hda101 expression also affected histone modifications other than acetylation, including histone H3 dimethylation at Lys-4 and Lys-9 and phosphorylation at Ser-10.	Lysine	132-135	histone deacetylase HDA101	Zea mays	16-22
17468264-6	2007	Perturbation of hda101 expression also affected histone modifications other than acetylation, including histone H3 dimethylation at Lys-4 and Lys-9 and phosphorylation at Ser-10.	Lysine	142-145	histone deacetylase HDA101	Zea mays	16-22
17320160-0	2007	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	Lysine	81-87	lysine demethylase 5C	Homo sapiens	37-41
21130870-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type, K158R mutant, or K209R mutant TAK1 reveals that TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced IKK, p38 and JNK activation.	Lysine	132-135	mitogen-activated protein kinase kinase kinase 7	Mus musculus	18-22
21130870-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type, K158R mutant, or K209R mutant TAK1 reveals that TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced IKK, p38 and JNK activation.	Lysine	132-135	mitogen-activated protein kinase kinase kinase 7	Mus musculus	109-113
17320160-0	2007	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	Lysine	81-87	lysine demethylase 5C	Homo sapiens	42-49
24615260-3	2014	JAK3 is inactivated by replacement of lysine by alanine in the catalytic subunit ((K855A)JAK3).	Lysine	38-44	Janus kinase 3 (a protein tyrosine kinase, leukocyte) L homeolog	Xenopus laevis	0-4
17218313-3	2007	DUR3 catalyzed the uptake of polyamines together with urea, and SAM3 was found to catalyze the uptake of polyamines together with S-adenosylmethionine, glutamic acid, and lysine.	Lysine	171-177	bifunctional polyamine/amino acid permease SAM3	Saccharomyces cerevisiae S288C	64-68
24615260-3	2014	JAK3 is inactivated by replacement of lysine by alanine in the catalytic subunit ((K855A)JAK3).	Lysine	38-44	Janus kinase 3 (a protein tyrosine kinase, leukocyte) L homeolog	Xenopus laevis	89-93
21286664-7	2011	The ratio of histone H3 lysine 9 methylation to histone H3 lysine 4 methylation of the chromatin containing the NDN promoter in the immortal WI-38VA13 cells was greater than that in the parental cells, suggesting chromatin structure-mediated regulation of NDN expression.	Lysine	59-65	necdin, MAGE family member	Homo sapiens	112-115
24583076-1	2014	BACKGROUND: P19 mouse embryonic carcinoma cells are conventionally induced to differentiate into neural cells by suspension culture in the presence of retinoic acid to form cell aggregates, followed by adhesion culture in a poly-l-lysine-coated dish.	Lysine	224-237	interleukin 23, alpha subunit p19	Mus musculus	12-15
21320024-3	2011	Set9 methylates E2F1 at lysine 185, a conserved residue in the DNA-binding domain of E2F family proteins.	Lysine	24-30	E2F transcription factor 1 L homeolog	Xenopus laevis	16-20
17243755-0	2007	Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).	Lysine	55-58	growth hormone releasing hormone	Rattus norvegicus	79-110
17243755-0	2007	Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).	Lysine	55-58	growth hormone releasing hormone	Rattus norvegicus	112-115
17243755-0	2007	Site-specific PEGylation for high-yield preparation of Lys(21)-amine PEGylated growth hormone-releasing factor (GRF) (1-29) using a GRF(1-29) derivative FMOC-protected at Tyr(1) and Lys(12).	Lysine	55-58	growth hormone releasing hormone	Rattus norvegicus	132-135
21320024-5	2011	We also found that LSD1 demethylates E2F1 at lysine 185 and reduces E2F1-mediated cell death.	Lysine	45-51	E2F transcription factor 1 L homeolog	Xenopus laevis	37-41
24660775-5	2014	Analysis by gel electrophoresis and mass spectrometry revealed transfer of this fluorophore from IgG to specific lysines of its binding partner SpA but not to bovine serum albumin (BSA) as a nonbinding control.	Lysine	113-120	surfactant protein A1	Homo sapiens	144-147
21177652-2	2011	A key feature of CHD1 is the presence of two chromodomains, which can bind to histone H3 methylated at lysine 4 and thus might serve to recruit and/or maintain CHD1 at the chromatin.	Lysine	103-109	Chromodomain-helicase-DNA-binding protein 1	Drosophila melanogaster	17-21
21177652-2	2011	A key feature of CHD1 is the presence of two chromodomains, which can bind to histone H3 methylated at lysine 4 and thus might serve to recruit and/or maintain CHD1 at the chromatin.	Lysine	103-109	Chromodomain-helicase-DNA-binding protein 1	Drosophila melanogaster	160-164
17182677-1	2007	A recent report sought to demonstrate that acetylation of specific lysines within integrase (IN) by the histone acetyltransferase (HAT) p300 regulates human immunodeficiency virus type 1 (HIV-1) integration and is essential for viral replication (A. Cereseto, L. Manganaro, M. I. Gutierrez, M. Terreni, A. Fittipaldi, M. Lusic, A. Marcello, and M. Giacca, EMBO J.	Lysine	67-74	E1A binding protein p300	Homo sapiens	136-140
17182677-4	2007	Although arginine substitution mutagenesis of the isolated CTD confirms that the majority of p300 acetylation occurs at lysine residues 264, 266, and 273, the pattern of acetylation is not uniform and a hierarchy of reactivity can be established.	Lysine	120-126	E1A binding protein p300	Homo sapiens	93-97
24660775-6	2014	Examination of an X-ray structure of IgG bound to SpA revealed that the fluorophore was selectively transferred between amino groups of lysines that reside within ~10 A at the protein-protein interface.	Lysine	136-143	surfactant protein A1	Homo sapiens	50-53
21490953-9	2011	Mutation of lysines at a potential site of SUMOylation in the CA region of the Gag gene reduced the SUMO-1 block and the TRIM5alpha restriction of N-MLV.	Lysine	12-19	small ubiquitin like modifier 1	Homo sapiens	100-106
17132685-5	2007	Alpha4, alpha5, and beta3 subunits all have a homologous glutamate in M2 that contributes to high Ca2+ permeability, whereas beta2 has a lysine at this position.	Lysine	137-143	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	125-130
21490953-9	2011	Mutation of lysines at a potential site of SUMOylation in the CA region of the Gag gene reduced the SUMO-1 block and the TRIM5alpha restriction of N-MLV.	Lysine	12-19	tripartite motif containing 5	Homo sapiens	121-131
24134677-2	2014	We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes.	Lysine	51-57	Lysine-specific demethylase rbr-2;[Histone H3]-trimethyl-L-lysine(4) demethylase	Caenorhabditis elegans	80-85
17210640-0	2007	The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.	Lysine	118-124	extra sexcombs	Drosophila melanogaster	29-32
17210640-2	2007	The 600-kDa E(Z)/ESC complex, also known as Polycomb repressive complex 2 (PRC2), specifically methylates histone H3 lysine 27 (H3 K27) through the intrinsic histone methyltransferase (HMTase) activity of the E(Z) SET domain.	Lysine	117-123	extra sexcombs	Drosophila melanogaster	17-20
21239494-0	2011	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	Lysine	0-3	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	36-40
24134677-2	2014	We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes.	Lysine	51-57	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	90-95
21239494-3	2011	In this study, we demonstrated that SDS3 readily undergoes endogenous polyubiquitination, which is associated specifically with Lys-63-branched polyubiquitin chains and not with Lys-48-branched polyubiquitin chains.	Lysine	128-131	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	36-40
21239494-4	2011	Further, we also demonstrated that USP17 specifically deubiquitinates Lys-63-linked ubiquitin chains from SDS3 and regulates its biological functions.	Lysine	70-73	SDS3 homolog, SIN3A corepressor complex component	Homo sapiens	106-110
24686445-4	2014	Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury.	Lysine	154-157	lysine acetyltransferase 2B	Homo sapiens	114-118
21131289-1	2011	WNK1 (with-no-lysine[K]-1) is a protein kinase of which mutations cause a familial hypertension and hyperkalemia syndrome known as pseudohypoaldosteronism type 2 (PHA2).	Lysine	14-20	WNK lysine deficient protein kinase 1	Mus musculus	0-4
17274598-2	2007	Brg1 contains a bromodomain that has been shown to anchor the entire complex to promoter nucleosomes by interacting with histones that are acetylated at specific lysine residues.	Lysine	162-168	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	0-4
24508213-3	2014	METHODS: The PSMA/GRPr dual targeting ligand precursor [DUPA-6-Ahx-K-5-Ava-BBN(7-14)NH2], was synthesized by solid-phase and manual peptide synthesis, after which NODAGA was added via manual conjugation to the epsilon-amine of lysine (K).	Lysine	227-233	gastrin releasing peptide receptor	Mus musculus	18-22
17172467-6	2007	In the converse situation, when Gln-476 of NCKX4 was converted to Lys, the corresponding residue in NCKX2, both the K(+) and Ca(2+) affinities were reduced.	Lysine	66-69	solute carrier family 24 member 4	Homo sapiens	43-48
17212354-0	2007	Histone H1-like, lysine-rich low complexity amino acid extensions in mosquito ribosomal proteins RpL23a and RpS6 have evolved independently.	Lysine	17-23	Ribosomal protein S6	Drosophila melanogaster	108-112
21139059-9	2011	An mGluR2-positive allosteric modulator, 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride (LY 487379), resulted in leftward shifts of the LY 379268 dose-response curve for both postsynaptic and presynaptic actions.	Lysine	142-144	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	3-9
21139059-9	2011	An mGluR2-positive allosteric modulator, 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride (LY 487379), resulted in leftward shifts of the LY 379268 dose-response curve for both postsynaptic and presynaptic actions.	Lysine	189-191	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	3-9
24468548-3	2014	We now report the generation and characterization of a far-red ghrelin analog, [Dpr(3)(octanoyl), Lys(19)(Cy5)]ghrelin (1-19), and show that it can be used to image changes in GHS-R in developing cardiomyocytes.	Lysine	98-101	ghrelin	Mus musculus	63-70
21308878-8	2011	Changing E68* in GLP-1R to the corresponding Lys of GCGR reduced receptor activity for natural GLP-1 hormones by eightfold.	Lysine	45-48	glucagon receptor	Homo sapiens	52-56
17145940-7	2007	However, agonists of NOD2, such as muramyl dipeptide and lysine-containing muramyl tripeptides, were not affected by amidation of the alpha-carboxylic acid of iso-glutamic acid.	Lysine	57-63	nucleotide binding oligomerization domain containing 2	Homo sapiens	21-25
17145766-5	2007	G9a, which was coimmunoprecipitated with hepatic SHP, methylated Lys-9 of histone 3 (H3K9) in vitro.	Lysine	65-68	nuclear receptor subfamily 0 group B member 2	Homo sapiens	49-52
21634123-6	2011	Lysine-rich histone H1 facilitates the binding of the HMGB1 with DNA by screening the negatively charged groups of the sugar-phosphate backbone of DNA and dicarboxylic amino-acid residues in the C-terminal domain of the HMGB1 protein.	Lysine	0-6	high mobility group box 1	Homo sapiens	54-59
17098252-12	2007	The alignment showed that yeast Chd1 lacks several key functional residues, which are responsible for specific binding to a methylated lysine residue in other chromodomains.	Lysine	135-141	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	32-36
24468548-3	2014	We now report the generation and characterization of a far-red ghrelin analog, [Dpr(3)(octanoyl), Lys(19)(Cy5)]ghrelin (1-19), and show that it can be used to image changes in GHS-R in developing cardiomyocytes.	Lysine	98-101	ghrelin	Mus musculus	111-118
21634123-6	2011	Lysine-rich histone H1 facilitates the binding of the HMGB1 with DNA by screening the negatively charged groups of the sugar-phosphate backbone of DNA and dicarboxylic amino-acid residues in the C-terminal domain of the HMGB1 protein.	Lysine	0-6	high mobility group box 1	Homo sapiens	220-225
24468548-3	2014	We now report the generation and characterization of a far-red ghrelin analog, [Dpr(3)(octanoyl), Lys(19)(Cy5)]ghrelin (1-19), and show that it can be used to image changes in GHS-R in developing cardiomyocytes.	Lysine	98-101	growth hormone secretagogue receptor	Homo sapiens	176-181
16862174-4	2007	A major acetylation site of Smad3 by p300/CBP is Lys-378 in the MH2 domain (Smad3C) known to be critical for the regulation of transcriptional activity.	Lysine	49-52	SMAD family member 3	Homo sapiens	28-33
24500717-6	2014	However, contrary to our expectation, the E3 ubiquitin ligase BBS11/TRIM32 was not responsible for the short half-life of NPHP7/Glis2 but instead promoted the accumulation of mixed Lys(48)/Lys(63)-polyubiquitylated NPHP7/Glis2 species.	Lysine	181-184	tripartite motif containing 32	Danio rerio	62-67
16862174-4	2007	A major acetylation site of Smad3 by p300/CBP is Lys-378 in the MH2 domain (Smad3C) known to be critical for the regulation of transcriptional activity.	Lysine	49-52	E1A binding protein p300	Homo sapiens	37-41
16862177-5	2007	The site of ubiquitin attachment via UbcH5 was mapped, and is shown to involve three HIF-1alpha lysines, K532, K538 and K547, and the same aligned lysines in EPAS.	Lysine	96-103	ubiquitin conjugating enzyme E2 D1	Homo sapiens	37-42
16862177-6	2007	Only one of these lysines need to be intact for full ubiquitination to occur, analogous to the mechanism of Sic1 ubiquitination by the SCF/Cdc34 complex and further strengthening the functional link between the VHL and SCF-E3 ubiquitin ligases.	Lysine	18-25	von Hippel-Lindau tumor suppressor	Homo sapiens	211-214
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-27	von Hippel-Lindau tumor suppressor	Homo sapiens	224-227
16862177-7	2007	We also report that lysines can be moved around the HIF-1alpha sequence with only minor losses in ubiquitination efficiency, thus suggesting HIF-1alpha and EPAS regulation by hypoxia depends primarily on an interaction with VHL per se, rather than the highly specific positioning of flanking lysine acceptors.	Lysine	20-26	von Hippel-Lindau tumor suppressor	Homo sapiens	224-227
21189329-7	2011	The increased TGF-beta signaling due to SMAD7 reduction could be effectively inhibited by a novel clinically relevant TBRI (ALK5 kinase) inhibitor, LY-2157299.	Lysine	148-150	transforming growth factor, beta 1	Mus musculus	14-22
21189329-7	2011	The increased TGF-beta signaling due to SMAD7 reduction could be effectively inhibited by a novel clinically relevant TBRI (ALK5 kinase) inhibitor, LY-2157299.	Lysine	148-150	SMAD family member 7	Mus musculus	40-45
21189329-9	2011	Furthermore, in vivo administration of LY-2157299 ameliorated anemia in a TGF-beta overexpressing transgenic mouse model of bone marrow failure.	Lysine	39-41	transforming growth factor, beta 1	Mus musculus	74-82
21209336-0	2011	Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.	Lysine	58-64	ubiquitin related modifier 1	Homo sapiens	35-39
21209336-3	2011	Here, we show that Urm1 is conjugated to lysine residues of target proteins and that oxidative stress enhances protein urmylation in both Saccharomyces cerevisiae and mammalian cells.	Lysine	41-47	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	19-23
21209336-6	2011	We have confirmed that the peroxiredoxin Ahp1 is such a substrate in S. cerevisiae and found that Urm1 targets a specific lysine residue of Ahp1 in vivo.	Lysine	122-128	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	41-45
17209547-0	2007	Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280.	Lysine	89-95	UDP-glucose 6-dehydrogenase	Homo sapiens	26-51
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	82-88	E1A binding protein p300	Homo sapiens	48-52
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	99-102	E1A binding protein p300	Homo sapiens	48-52
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 7	Homo sapiens	13-17
21209336-6	2011	We have confirmed that the peroxiredoxin Ahp1 is such a substrate in S. cerevisiae and found that Urm1 targets a specific lysine residue of Ahp1 in vivo.	Lysine	122-128	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	98-102
21209336-6	2011	We have confirmed that the peroxiredoxin Ahp1 is such a substrate in S. cerevisiae and found that Urm1 targets a specific lysine residue of Ahp1 in vivo.	Lysine	122-128	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	140-144
24500717-6	2014	However, contrary to our expectation, the E3 ubiquitin ligase BBS11/TRIM32 was not responsible for the short half-life of NPHP7/Glis2 but instead promoted the accumulation of mixed Lys(48)/Lys(63)-polyubiquitylated NPHP7/Glis2 species.	Lysine	181-184	tripartite motif containing 32	Danio rerio	68-74
24500717-6	2014	However, contrary to our expectation, the E3 ubiquitin ligase BBS11/TRIM32 was not responsible for the short half-life of NPHP7/Glis2 but instead promoted the accumulation of mixed Lys(48)/Lys(63)-polyubiquitylated NPHP7/Glis2 species.	Lysine	189-192	tripartite motif containing 32	Danio rerio	62-67
24500717-6	2014	However, contrary to our expectation, the E3 ubiquitin ligase BBS11/TRIM32 was not responsible for the short half-life of NPHP7/Glis2 but instead promoted the accumulation of mixed Lys(48)/Lys(63)-polyubiquitylated NPHP7/Glis2 species.	Lysine	189-192	tripartite motif containing 32	Danio rerio	68-74
21209336-8	2011	First, Urm1 is appended to lysine residues of three components that function in its own pathway (i.e., MOCS3, ATPBD3, and CTU2).	Lysine	27-33	ubiquitin related modifier 1	Homo sapiens	7-11
24497632-1	2014	A previous study from our laboratory reported a preferential conservation of arginine relative to lysine in the C-terminal tail (CTT) of HIV-1 envelope (Env).	Lysine	98-104	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	153-156
17054919-6	2007	Furthermore, Lys(34)-PEG-GLP-1 showed the most prominent glucose-stabilizing capability, evaluated via an oral glucose tolerance test in db/db mice by considering the following three crucial factors: (i) maximum blood glucose level (BGL), (ii) required time to lower the BGL below 100mg/dl, and (iii) total hypoglycemic degree.	Lysine	13-16	glucagon	Mus musculus	25-30
17054919-7	2007	Additionally, Lys(34)-PEG-GLP-1 had longer half-lives than the other PEGylated GLP-1s in the dipeptidyl peptidase IV (DPP IV) inhibitor-treated liver or kidney homogenate, and its stability against DPP IV was also comparable to that of Lys(26)-PEG-GLP-1.	Lysine	14-17	dipeptidylpeptidase 4	Rattus norvegicus	118-124
17054919-7	2007	Additionally, Lys(34)-PEG-GLP-1 had longer half-lives than the other PEGylated GLP-1s in the dipeptidyl peptidase IV (DPP IV) inhibitor-treated liver or kidney homogenate, and its stability against DPP IV was also comparable to that of Lys(26)-PEG-GLP-1.	Lysine	14-17	dipeptidylpeptidase 4	Rattus norvegicus	198-204
21297974-6	2011	We found that the pro-angiogenic effects are partly mediated through reduced repression by miR-101 of the histone-methyltransferase EZH2, a member of the Polycomb group family, thereby increasing methylation of histone H3 at lysine 27 and transcriptome alterations.	Lysine	225-231	microRNA 101a	Mus musculus	91-98
24497632-8	2014	These results provide for the first time a functional explanation to the preferred incorporation of arginine, relative to lysine, in the CTT of HIV-1 Env.	Lysine	122-128	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	150-153
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	88-91	ring finger protein 168	Homo sapiens	15-21
21119616-3	2011	In pRb, lysine (K) 810 represents the essential and conserved basic residue (SPXK) required for cyclin/Cdk recognition and phosphorylation.	Lysine	8-14	RB transcriptional corepressor 1	Homo sapiens	3-6
21119616-7	2011	Thus, the regulation of phosphorylation by Cdks reflects the combined interplay with methylation events, and more generally the targeted methylation of a lysine residue within a Cdk-consensus site in pRb represents an important point of control in cell cycle progression.	Lysine	154-160	RB transcriptional corepressor 1	Homo sapiens	200-203
17406994-0	2007	The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution.	Lysine	54-60	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	27-32
17406994-3	2007	In mammals and flies, SUZ12/Su(z)12 is necessary for trimethylation of histone H3 on lysine 27 (H3K27me3) on facultative heterochromatin.	Lysine	85-91	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	22-27
17406994-3	2007	In mammals and flies, SUZ12/Su(z)12 is necessary for trimethylation of histone H3 on lysine 27 (H3K27me3) on facultative heterochromatin.	Lysine	85-91	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	28-35
17406994-5	2007	We investigated the role of Suz12 in constitutive heterochromatin and discovered that Suz12 is required for histone H3 lysine 9 tri-methylation (H3K9me3) in differentiated but not undifferentiated mouse embryonic stem cells.	Lysine	119-125	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	86-91
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	88-91	ring finger protein 2	Homo sapiens	26-32
17212651-3	2007	G9a is a euchromatin-localized histone methyltransferase (HMT) and catalyzes methylation of histone H3 at lysines 9 and 27 (H3-K9 and -K27).	Lysine	106-113	histamine N-methyltransferase	Mus musculus	31-56
17212651-3	2007	G9a is a euchromatin-localized histone methyltransferase (HMT) and catalyzes methylation of histone H3 at lysines 9 and 27 (H3-K9 and -K27).	Lysine	106-113	histamine N-methyltransferase	Mus musculus	58-61
21194957-2	2011	Based on the previous work of L-lysine amide derivatives in our laboratory, we designed and synthesized two series of L-lysine ureido derivatives as APN inhibitors.	Lysine	30-38	alanyl aminopeptidase, membrane	Homo sapiens	149-152
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	88-91	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	33-37
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	88-91	H2A clustered histone 18	Homo sapiens	76-79
21167713-6	2011	Furthermore, we find that the binding of histone-interaction domains from BPTF, CHD1, and RAG2 to H3 lysine 4 trimethylation is also influenced by combinatorial PTMs.	Lysine	101-107	chromodomain helicase DNA binding protein 1	Homo sapiens	80-84
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	88-91	H2A.X variant histone	Homo sapiens	80-84
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	102-105	ring finger protein 168	Homo sapiens	15-21
17024410-2	2007	Keratinocyte transglutaminase 1 (TGase 1) catalyzes amide crosslinking between glutamine and lysine residues on precursor proteins forming the impermeable layers of the epidermal cell envelopes (CE), the highly insoluble membranous structures of the stratum corneum.	Lysine	93-99	transglutaminase 1	Homo sapiens	13-31
17024410-2	2007	Keratinocyte transglutaminase 1 (TGase 1) catalyzes amide crosslinking between glutamine and lysine residues on precursor proteins forming the impermeable layers of the epidermal cell envelopes (CE), the highly insoluble membranous structures of the stratum corneum.	Lysine	93-99	transglutaminase 1	Homo sapiens	33-40
21200139-2	2011	One of these enzymes, PR-Set7/Set8/KMT5a, is the sole histone methyltransferase responsible for the monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	130-136	lysine methyltransferase 5A	Homo sapiens	22-29
21200139-2	2011	One of these enzymes, PR-Set7/Set8/KMT5a, is the sole histone methyltransferase responsible for the monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	130-136	lysine methyltransferase 5A	Homo sapiens	30-34
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	102-105	ring finger protein 2	Homo sapiens	26-32
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	102-105	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	33-37
17393063-0	2007	L-lysine as a recognition molecule for the VAP-1 function of SSAO.	Lysine	0-8	amine oxidase copper containing 3	Homo sapiens	43-48
17393063-0	2007	L-lysine as a recognition molecule for the VAP-1 function of SSAO.	Lysine	0-8	amine oxidase copper containing 3	Homo sapiens	61-65
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	102-105	H2A clustered histone 18	Homo sapiens	76-79
17393063-5	2007	The presence of L-lysine during the oxidation of benzylamine resulted in time- and dose-dependent inhibition of SSAO activity, in a process that was dependent on the H(2)O(2) formed during benzylamine oxidation.	Lysine	16-24	amine oxidase copper containing 3	Homo sapiens	112-116
24603765-2	2014	In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.	Lysine	102-105	H2A.X variant histone	Homo sapiens	80-84
21200139-2	2011	One of these enzymes, PR-Set7/Set8/KMT5a, is the sole histone methyltransferase responsible for the monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes.	Lysine	130-136	lysine methyltransferase 5A	Homo sapiens	35-40
24598757-6	2014	Moreover, the combination of surface lysine methylation and the introduction of K125R and V301L mutations enabled the determination of the X-ray crystallographic structure of the corresponding AKR1B10-NADP(+)-JF0064 complex.	Lysine	37-43	aldo-keto reductase family 1 member B10	Homo sapiens	193-200
21164265-3	2011	We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor.	Lysine	280-286	clock circadian regulator	Homo sapiens	75-80
17617644-3	2007	Previous findings, including the crystal structure of UL44, have led to the hypothesis that UL44 binds DNA as a dimer via lysine residues.	Lysine	122-128	DNA polymerase processivity subunit	Human betaherpesvirus 5	54-58
17617644-3	2007	Previous findings, including the crystal structure of UL44, have led to the hypothesis that UL44 binds DNA as a dimer via lysine residues.	Lysine	122-128	DNA polymerase processivity subunit	Human betaherpesvirus 5	92-96
21164265-3	2011	We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor.	Lysine	308-314	clock circadian regulator	Homo sapiens	75-80
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Lysine	118-124	ornithine decarboxylase 1	Homo sapiens	163-166
21047957-4	2011	Furthermore, two lysine residues in the C terminus of NS1 were identified as SUMO1 acceptor sites.	Lysine	17-23	small ubiquitin like modifier 1	Homo sapiens	77-82
17478498-7	2007	Elevated levels of histone H3 dimethylated on lysine 9 were seen in FRDA cells consistent with a more repressive chromatin organization.	Lysine	46-52	frataxin	Homo sapiens	68-72
23904095-12	2014	Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ.	Lysine	118-124	ornithine decarboxylase antizyme 1	Homo sapiens	203-205
24426167-8	2014	Transcript analysis of candidate innate immune gene (clec-60, clec-87, lys-7, ilys-3, scl-2, cpr-2, F08G5.6, atf-7, age-1, bec-1 and daf-16) regulations in the host during S. Typhi infection have been assessed through qPCR analysis to understand the activation of immune signaling pathways during S. Typhi infections.	Lysine	14-17	VWFA domain-containing protein	Caenorhabditis elegans	53-60
17516250-1	2007	Enterokinase (EC 3.4.21.9) is a serine proteinase of the intestinal brush border that exhibits specificity for the sequence (Asp)(4)-Lys and converts trypsinogen into its active form, trypsin.	Lysine	133-136	transmembrane serine protease 15	Bos taurus	0-12
21796528-4	2011	We have shown that AR is modified by SUMO-1 at two conserved lysine residues in its N-terminal domain.	Lysine	61-67	small ubiquitin like modifier 1	Homo sapiens	37-43
21120624-5	2011	Furthermore, we identified the five lysine residues of the Pellino-1 protein where SUMO-1 covalently attaches.	Lysine	36-42	small ubiquitin like modifier 1	Homo sapiens	83-89
23563275-7	2014	Our previous report demonstrated that azilsartan mainly interacts with Tyr(113), Lys(199), and Gln(257) in the AT1 receptor.	Lysine	81-84	angiotensin II receptor type 1	Homo sapiens	111-114
21131967-0	2011	Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.	Lysine	0-6	RELA proto-oncogene, NF-kB subunit	Homo sapiens	44-48
22140534-3	2011	We have recently reported that ASH1 methylates histone H3 at lysine 36 (K36) but its biological function has remained elusive.	Lysine	61-67	ASH1 like histone lysine methyltransferase	Homo sapiens	31-35
22140559-6	2011	Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity.	Lysine	146-149	mucin 1, cell surface associated	Homo sapiens	84-88
17158804-6	2006	When fused to a heterologous DNA-binding domain, this short 26-aa motif was sufficient for transcriptional repression, recruitment of PcG proteins to DNA, and methylation of histone H3 lysine 27.	Lysine	185-191	Polycomb	Drosophila melanogaster	134-137
16540235-6	2006	It must be determined whether two other PTH peptides, rhPTH-(1-84) [Preos]and [Leu(27)]cyclo(Glu(22)-Lys(26))hPTH-(1-31)NH(2) [Ostabolin-C]) are as effective as or better than rhPTH-(1-34)(Forteo).	Lysine	101-104	parathyroid hormone	Mus musculus	40-43
16919702-4	2006	It has now been demonstrated here that acetylation of a lysine, equivalent to position 261 in Ad12 E1A and position 285 in Ad5E1A, in a synthetic peptide disrupts the binding to CtBP1 and CtBP2 and alters the K(i) of the peptide, indicative of a reduction in the affinity of the peptide for CtBP1 and CtBP2, but only to a rather limited extent (less than 2-fold).	Lysine	56-62	C-terminal binding protein 1	Homo sapiens	178-183
16919702-4	2006	It has now been demonstrated here that acetylation of a lysine, equivalent to position 261 in Ad12 E1A and position 285 in Ad5E1A, in a synthetic peptide disrupts the binding to CtBP1 and CtBP2 and alters the K(i) of the peptide, indicative of a reduction in the affinity of the peptide for CtBP1 and CtBP2, but only to a rather limited extent (less than 2-fold).	Lysine	56-62	C-terminal binding protein 1	Homo sapiens	291-296
24449390-0	2014	Sulfo-NHS-SS-biotin derivatization: a versatile tool for MALDI mass analysis of PTMs in lysine-rich proteins.	Lysine	88-94	parathymosin	Homo sapiens	80-84
17110336-3	2006	E4F1 stimulates oligo-ubiquitylation in the hinge region of p53 on lysine residues distinct from those targeted by Hdm2 and previously described to be acetylated by the acetyltransferase PCAF.	Lysine	67-73	E4F transcription factor 1	Homo sapiens	0-4
21949728-6	2011	These data show that upon stimulation with IL-4 and an anti-CD40 antibody that mimics T cell help, the nucleosomes of the switch regions are highly modified on histone H3, accumulating acetylation marks and tri-methylation of lysine 4.	Lysine	226-232	CD40 molecule	Homo sapiens	60-64
21829513-1	2011	PR-Set7/Set8/KMT5a is a chromatin-modifying enzyme that specifically monomethylates lysine 20 of histone H4 (H4K20me1).	Lysine	84-90	lysine methyltransferase 5A	Homo sapiens	0-7
24449390-5	2014	We present here how the use of sulfo-NHS-SS-biotin derivatization of lysine side chain can help to detect PTMs in lysine-rich proteins.	Lysine	69-75	parathymosin	Homo sapiens	106-110
21829513-1	2011	PR-Set7/Set8/KMT5a is a chromatin-modifying enzyme that specifically monomethylates lysine 20 of histone H4 (H4K20me1).	Lysine	84-90	lysine methyltransferase 5A	Homo sapiens	8-12
24449390-5	2014	We present here how the use of sulfo-NHS-SS-biotin derivatization of lysine side chain can help to detect PTMs in lysine-rich proteins.	Lysine	114-120	parathymosin	Homo sapiens	106-110
21829513-1	2011	PR-Set7/Set8/KMT5a is a chromatin-modifying enzyme that specifically monomethylates lysine 20 of histone H4 (H4K20me1).	Lysine	84-90	lysine methyltransferase 5A	Homo sapiens	13-18
17067581-0	2006	Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branching.	Lysine	97-100	Rev	Human immunodeficiency virus 1	20-23
24900876-2	2014	As evidenced by X-ray crystallography the inhibitors bind to the lysine binding site in plasmin thus preventing plasmin from binding to fibrin, hence blocking the protein-protein interaction.	Lysine	65-71	plasminogen	Homo sapiens	88-95
17067581-4	2006	Mutation of the three lysine residues of Rev showed that the site of ubiquitin conjugation is Lys-115.	Lysine	22-28	Rev	Human immunodeficiency virus 1	41-44
17067581-4	2006	Mutation of the three lysine residues of Rev showed that the site of ubiquitin conjugation is Lys-115.	Lysine	94-97	Rev	Human immunodeficiency virus 1	41-44
20943666-4	2010	In vitro binding studies revealed that both the human and Drosophila MSL3 chromo-barrel domains bind preferentially to peptides representing the mono or dimethyl isoform of lysine 20 on the histone H4 N-terminal tail (H4K20Me(1) or H4K20Me(2)).	Lysine	173-179	male-specific lethal 3	Drosophila melanogaster	69-73
16920835-8	2006	Significantly, analogs of these residues in pol beta (Lys(280), Arg(283), Arg(258), Phe(272), and Tyr(271), respectively) have demonstrated roles in determining enzyme efficiency and fidelity.	Lysine	54-57	DNA polymerase beta	Homo sapiens	44-52
21157980-6	2010	Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61].	Lysine	66-72	aldehyde dehydrogenase 2 family member	Homo sapiens	60-65
24900876-2	2014	As evidenced by X-ray crystallography the inhibitors bind to the lysine binding site in plasmin thus preventing plasmin from binding to fibrin, hence blocking the protein-protein interaction.	Lysine	65-71	plasminogen	Homo sapiens	112-119
21157980-6	2010	Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61].	Lysine	74-77	aldehyde dehydrogenase 2 family member	Homo sapiens	60-65
21157980-6	2010	Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61].	Lysine	103-106	aldehyde dehydrogenase 2 family member	Homo sapiens	60-65
24200862-8	2014	The external aldimine of kynurenine and PLP is then deprotonated by the epsilon-amino group of Lys-227 to give a quinonoid intermediate, which is reprotonated at C-4" to give a ketimine.	Lysine	95-98	pyridoxal phosphatase	Homo sapiens	40-43
21157980-6	2010	Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61].	Lysine	103-106	aldehyde dehydrogenase 2 family member	Homo sapiens	60-65
21157980-6	2010	Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61].	Lysine	103-106	aldehyde dehydrogenase 2 family member	Homo sapiens	60-65
21157980-8	2010	ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33).	Lysine	21-24	aldehyde dehydrogenase 2 family member	Homo sapiens	15-20
16980402-2	2006	We show that cre-Lox-mediated excision of 21 kb from both Xist alleles in female mouse fibroblasts led to the appearance of two histone modifications throughout the inactive X chromosome usually associated with euchromatin: histone H4 acetylation and histone H3 lysine-4 methylation.	Lysine	262-268	lysyl oxidase	Mus musculus	17-20
24362066-10	2014	The mRNA upregulation was associated with decreased histone H3 lysine 9 dimethylation (H3K9me2) levels, the epigenetic mark deposited by Ehmt1, in the promoter region of these genes.	Lysine	63-69	euchromatic histone methyltransferase 1	Mus musculus	137-142
20699270-0	2010	Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.	Lysine	9-15	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	74-78
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	keratin 27	Homo sapiens	79-82
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	keratin 31	Homo sapiens	84-87
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	113-117
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	185-189
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	nucleophosmin 1	Homo sapiens	208-212
17040568-7	2006	We next transfected LbetaT2 cells with wild-type and kinase-deficient (Lys to Arg, KR) forms of ALK4 and ALK7 and examined the effects of these receptors on activin A and B stimulated Fshb promoter-reporter activity.	Lysine	71-74	activin A receptor, type 1B	Mus musculus	96-100
24418777-2	2014	Building upon the construct of DOTA-Ahx-(D-Lys(6)-GnRH1) we previously reported, an aromatic amino acid of D-Phe was inserted either between the DOTA and Ahx or between the Ahx and D-Lys(6) to generate new DOTA-D-Phe-Ahx-(D-Lys(6)-GnRH) or DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) peptides.	Lysine	42-46	gonadotropin releasing hormone 1	Homo sapiens	50-55
16990801-4	2006	Smad2-recruited p300 exhibits an altered substrate specificity, specifically acetylating nucleosomal histone H3 at lysines 9 and 18, and these modifications are also detected on an endogenous Smad2-dependent promoter in a ligand-induced manner.	Lysine	115-122	SMAD family member 2	Homo sapiens	0-5
16990801-4	2006	Smad2-recruited p300 exhibits an altered substrate specificity, specifically acetylating nucleosomal histone H3 at lysines 9 and 18, and these modifications are also detected on an endogenous Smad2-dependent promoter in a ligand-induced manner.	Lysine	115-122	E1A binding protein p300	Homo sapiens	16-20
20798234-8	2010	These data suggest a model whereby DOT1L-dependent lysine 79 of histone H3 methylation serves as a critical regulator of a differentiation switch during early hematopoiesis, regulating steady-state levels of GATA2 and PU.1 transcription, thus controlling numbers of circulating erythroid and myeloid cells.	Lysine	51-57	GATA binding protein 2	Homo sapiens	208-213
24418777-2	2014	Building upon the construct of DOTA-Ahx-(D-Lys(6)-GnRH1) we previously reported, an aromatic amino acid of D-Phe was inserted either between the DOTA and Ahx or between the Ahx and D-Lys(6) to generate new DOTA-D-Phe-Ahx-(D-Lys(6)-GnRH) or DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) peptides.	Lysine	42-46	gonadotropin releasing hormone 1	Homo sapiens	50-54
24418777-2	2014	Building upon the construct of DOTA-Ahx-(D-Lys(6)-GnRH1) we previously reported, an aromatic amino acid of D-Phe was inserted either between the DOTA and Ahx or between the Ahx and D-Lys(6) to generate new DOTA-D-Phe-Ahx-(D-Lys(6)-GnRH) or DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) peptides.	Lysine	42-46	gonadotropin releasing hormone 1	Homo sapiens	231-235
16840712-0	2006	Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor.	Lysine	19-26	purinergic receptor P2X 3	Homo sapiens	62-68
24418777-4	2014	The tumor targeting and pharmacokinetic properties of (111)In-DOTA-Ahx-D-Phe-(D-Lys(6)-GnRH) was determined in MDA-MB-231 human breast cancer-xenografted nude mice.	Lysine	79-83	gonadotropin releasing hormone 1	Homo sapiens	87-91
16840712-2	2006	We recorded membrane currents from human embryonic kidney cells expressing P2X subunits and found that lysine-to-alanine substitutions at equivalent positions in the P2X3 receptor (Lys63 and Lys299) also prevented channel function.	Lysine	103-109	purinergic receptor P2X 3	Homo sapiens	166-170
16840712-6	2006	The rescue of the single lysine mutant P2X2 subunit by wild-type P2X3 (but not the converse) suggests that the heteromeric channel contains one P2X2 and two P2X3 subunits and that the receptor functions essentially normally as long as two subunits are not mutated.	Lysine	25-31	purinergic receptor P2X 3	Homo sapiens	65-69
20833725-5	2010	The aspartate finger of VPS9a recognizes GDP beta-phosphate directly and pulls the P-loop lysine of ARA7 away from GDP beta-phosphate toward switch II to further destabilize GDP for its release during the transition from the GDP-bound to nucleotide-free intermediates in the nucleotide exchange reaction.	Lysine	90-96	Ras-related small GTP-binding family protein	Arabidopsis thaliana	100-104
16840712-6	2006	The rescue of the single lysine mutant P2X2 subunit by wild-type P2X3 (but not the converse) suggests that the heteromeric channel contains one P2X2 and two P2X3 subunits and that the receptor functions essentially normally as long as two subunits are not mutated.	Lysine	25-31	purinergic receptor P2X 3	Homo sapiens	157-161
24183806-6	2014	Molecular modeling, protein stability experiments and site-directed mutagenesis suggest that K27 variant may have an increased stability with respect to Q27 due to an ionic interaction between a lysine residue at position 27 and a glutamate residue at position 24.	Lysine	195-201	keratin 27	Homo sapiens	93-96
16887811-2	2006	The Polycomb group protein Enhancer of Zeste has been shown in vitro to methylate specifically lysine 27 and lysine 9 of histone H3 but the role of this modification in Polycomb silencing is unknown.	Lysine	95-101	Polycomb	Drosophila melanogaster	4-12
16887811-2	2006	The Polycomb group protein Enhancer of Zeste has been shown in vitro to methylate specifically lysine 27 and lysine 9 of histone H3 but the role of this modification in Polycomb silencing is unknown.	Lysine	109-115	Polycomb	Drosophila melanogaster	4-12
20966048-1	2010	Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated.	Lysine	43-46	lysine methyltransferase 5A	Homo sapiens	13-20
20966048-1	2010	Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated.	Lysine	43-46	lysine methyltransferase 5A	Homo sapiens	21-25
16887811-3	2006	We show that H3 trimethylated at lysine 27 is found on the entire Ubx gene silenced by Polycomb.	Lysine	33-39	Ultrabithorax	Drosophila melanogaster	66-69
24709419-6	2014	Our data further show that SMURF2 monoubiquitinates UBCH5 at lysine 144 to form an active complex required for efficient degradation of a RAS-family E3, beta-transducing repeat containing protein 1 (beta-TrCP1).	Lysine	61-67	ubiquitin conjugating enzyme E2 D1	Homo sapiens	52-57
16887811-3	2006	We show that H3 trimethylated at lysine 27 is found on the entire Ubx gene silenced by Polycomb.	Lysine	33-39	Polycomb	Drosophila melanogaster	87-95
16790436-6	2006	This two-site interaction between Keap1 and Nrf2 constrains the mobility of the target lysine residues in the Neh2 domain, increasing their average concentration in the vicinity of the Rbx-bound ubiquitin-conjugating enzyme, and thus the rate at which the transcription factor is ubiquitylated.	Lysine	87-93	nei like DNA glycosylase 2	Homo sapiens	110-114
20966048-1	2010	Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated.	Lysine	43-46	lysine methyltransferase 5A	Homo sapiens	26-31
20966048-1	2010	Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated.	Lysine	43-46	lysine methyltransferase 5A	Homo sapiens	192-199
23934913-6	2014	We identified candidate lysines by analyzing the structural and sequentially conserved N-glycosylation sites and lysines in bPLBD1 and in the homologous mouse PLBD2.	Lysine	24-31	phospholipase B domain containing 2	Mus musculus	159-164
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Lysine	115-118	phospholipase D1	Mus musculus	20-24
20974913-0	2010	Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.	Lysine	87-93	E1A binding protein p300	Homo sapiens	56-60
20974913-8	2010	Significantly, we identify H3 lysine 14 as the essential p300 acetylation substrate required for dissociation of the histone octamer from the promoter DNA.	Lysine	30-36	E1A binding protein p300	Homo sapiens	57-61
20676127-3	2010	In this study we report for the first time that ING2 can be sumoylated by small ubiquitin-like modifier 1 (SUMO1) on lysine 195 both in vitro and in vivo.	Lysine	117-123	inhibitor of growth family member 2	Homo sapiens	48-52
20676127-3	2010	In this study we report for the first time that ING2 can be sumoylated by small ubiquitin-like modifier 1 (SUMO1) on lysine 195 both in vitro and in vivo.	Lysine	117-123	small ubiquitin like modifier 1	Homo sapiens	74-105
20676127-3	2010	In this study we report for the first time that ING2 can be sumoylated by small ubiquitin-like modifier 1 (SUMO1) on lysine 195 both in vitro and in vivo.	Lysine	117-123	small ubiquitin like modifier 1	Homo sapiens	107-112
20723026-2	2010	Active TAFI attenuates fibrinolysis by removing C-terminal lysine residues from partially degraded fibrin, thereby inhibiting a potent positive feedback loop in the fibrinolytic cascade.	Lysine	59-65	carboxypeptidase B2	Homo sapiens	7-11
20953199-3	2010	Here, we show that the onset of licensing in mammalian cells coincides with an increase in histone H4 Lys 20 monomethylation (H4K20me1) at replication origins by the methyltransferase PR-Set7 (also known as Set8 or KMT5A).	Lysine	102-105	lysine methyltransferase 5A	Homo sapiens	184-191
20953199-3	2010	Here, we show that the onset of licensing in mammalian cells coincides with an increase in histone H4 Lys 20 monomethylation (H4K20me1) at replication origins by the methyltransferase PR-Set7 (also known as Set8 or KMT5A).	Lysine	102-105	lysine methyltransferase 5A	Homo sapiens	207-211
20953199-3	2010	Here, we show that the onset of licensing in mammalian cells coincides with an increase in histone H4 Lys 20 monomethylation (H4K20me1) at replication origins by the methyltransferase PR-Set7 (also known as Set8 or KMT5A).	Lysine	102-105	lysine methyltransferase 5A	Homo sapiens	215-220
20738173-1	2010	The pathway involving Bre1-dependent monoubiquitination of histone H2B lysine 123, which leads to Dot1-dependent methylation of histone H3 lysine 79 (H3K79me2), has been implicated in survival after exposure to ionizing radiation in Saccharomyces cerevisiae.	Lysine	71-77	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	22-26
20738173-1	2010	The pathway involving Bre1-dependent monoubiquitination of histone H2B lysine 123, which leads to Dot1-dependent methylation of histone H3 lysine 79 (H3K79me2), has been implicated in survival after exposure to ionizing radiation in Saccharomyces cerevisiae.	Lysine	139-145	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	22-26
21048924-10	2010	Statistical tests also showed gene-gene interaction of ADH1B Arg+ with ALDH2 Lys+ can bring more risk to ESCC (OR  = 13.46, 95% CI: 2.32-78.07).	Lysine	77-80	aldehyde dehydrogenase 2 family member	Homo sapiens	71-76
20932471-1	2010	PR-Set7/Set8 is a cell-cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20).	Lysine	66-72	lysine methyltransferase 5A	Homo sapiens	0-7
20932471-1	2010	PR-Set7/Set8 is a cell-cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20).	Lysine	66-72	lysine methyltransferase 5A	Homo sapiens	8-12
20932472-2	2010	During G2 and mitosis, Set8 catalyzes monomethylation of histone H4 on lysine 20 (H4K20me1), which promotes chromatin compaction.	Lysine	71-77	lysine methyltransferase 5A	Homo sapiens	23-27
19959491-2	2010	It was recently shown that thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and also fibrin-plasminogen interaction by the removal of lysine and arginine residues from fibrin monomers.	Lysine	160-166	carboxypeptidase B2	Homo sapiens	27-70
19959491-2	2010	It was recently shown that thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and also fibrin-plasminogen interaction by the removal of lysine and arginine residues from fibrin monomers.	Lysine	160-166	carboxypeptidase B2	Homo sapiens	72-76
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	serine protease 27	Homo sapiens	23-26
20876358-3	2010	This activation was largely suppressed by mutation of the Walker A lysines in the nucleotide-binding domains of SUR1: the remaining small (~10%), slowly developing component of MgATP activation was fully inhibited by the lipid kinase inhibitor LY294002.	Lysine	67-74	ATP binding cassette subfamily C member 8	Homo sapiens	112-116
20881113-8	2010	The PPT- and STX-induced [Ca(2+)](i) release and progesterone synthesis were blocked by LY 367385.	Lysine	88-90	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Mus musculus	13-16
20837538-3	2010	Previous studies have implicated NSD1 (KMT3B) in transcription and methylation of histone H3 at lysine 36 (H3-K36), but its molecular mechanism in these processes remains largely unknown.	Lysine	96-102	nuclear receptor binding SET domain protein 1	Homo sapiens	39-44
20718504-8	2010	Consistent with a critical role of the middle region in lipid-induced rPrP conversion, both disease-associated P105L and P102L mutations, localized between lysine residues in the positively charged region, significantly affected lipid-induced rPrP conversion.	Lysine	156-162	prion protein	Rattus norvegicus	70-74
20844582-3	2010	Our previous study showed that the SUMO E3 ligase PIASy interacts with VHL and induces VHL SUMOylation on lysine residue 171 (Cai et al, PLoS ONE, 2010, 5(3):e9720).	Lysine	106-112	von Hippel-Lindau tumor suppressor	Homo sapiens	71-74
20844582-3	2010	Our previous study showed that the SUMO E3 ligase PIASy interacts with VHL and induces VHL SUMOylation on lysine residue 171 (Cai et al, PLoS ONE, 2010, 5(3):e9720).	Lysine	106-112	von Hippel-Lindau tumor suppressor	Homo sapiens	87-90
20844582-4	2010	Here we further report that VHL also undergoes ubiquitylation on both lysine residues 171 and 196, which is blocked by PIASy.	Lysine	70-76	von Hippel-Lindau tumor suppressor	Homo sapiens	28-31
20844582-6	2010	Interestingly, substitution of lysine 171 and 196 to arginine of VHL abrogates its inhibitory function on the transcriptional activity of HIFalpha, and tube formation in vitro.	Lysine	31-37	von Hippel-Lindau tumor suppressor	Homo sapiens	65-68
20724660-5	2010	Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23).	Lysine	80-83	interferon regulatory factor 3	Mus musculus	33-37
23554652-6	2010	However, the LMP7 codon 145 Gln/Lys, Lys/Lys, and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group (OR=1.75, 95%CI=1.06~2.90; OR=3.16, 95%CI=1.23-8.12; OR = 1.94, 95%CI=1.21-3.12, respectively).	Lysine	32-35	proteasome 20S subunit beta 8	Homo sapiens	13-17
20582454-1	2010	OBJECTIVE: Folic acid and TAT peptide were conjugated on the octadecyl-quaternized, lysine-modified chitosan-cholesterol polymeric liposomes (FA-TATp-PLs) to investigate their potential feasibility for tumor-targeted drug delivery.	Lysine	84-90	tyrosine aminotransferase	Mus musculus	26-29
20336624-7	2010	Moreover, a significant increase in lysine 9 on histone H3 (H3K9) trimethylation at the promoter of NeuroD (a neural progenitor cell marker) was observed in the hippocampus of aged mice.	Lysine	36-42	neurogenic differentiation 1	Mus musculus	100-106
20671152-2	2010	Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defective immunoglobulin class switching.	Lysine	171-177	lysine methyltransferase 2C	Homo sapiens	78-82
20671152-2	2010	Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defective immunoglobulin class switching.	Lysine	171-177	lysine methyltransferase 2C	Homo sapiens	84-108
20671152-2	2010	Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defective immunoglobulin class switching.	Lysine	171-177	lysine methyltransferase 2B	Homo sapiens	110-114
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 7	Homo sapiens	38-42
20637912-6	2010	Conserved lysine residue 167 that is located in the NET inhibitory domain of ELK4 was identified as the main site of SUMO-1 conjugation.	Lysine	10-16	ETS transcription factor ELK4	Homo sapiens	77-81
20637912-6	2010	Conserved lysine residue 167 that is located in the NET inhibitory domain of ELK4 was identified as the main site of SUMO-1 conjugation.	Lysine	10-16	small ubiquitin like modifier 1	Homo sapiens	117-123
20699646-5	2010	One such modification is histone H3 lysine 56 acetylation (H3K56Ac), a mark of newly-synthesized histone H3 that regulates the interaction between H3-H4 and the histone chaperones CAF-1 and Rtt106 following DNA replication and DNA repair.	Lysine	36-42	chromatin assembly factor 1 subunit A	Homo sapiens	180-185
20699646-6	2010	Recently, we have shown that the lysine acetyltransferase Gcn5 and H3 N-terminal tail lysine acetylation also regulates the interaction between H3-H4 and CAF-1 to promote the deposition of newly-synthesized histones.	Lysine	33-39	chromatin assembly factor 1 subunit A	Homo sapiens	154-159
20516063-3	2010	Here we found that BZLF1 is conjugated at lysine 12 not only by SUMO-1 but also by SUMO-2 and 3.	Lysine	42-48	small ubiquitin like modifier 1	Homo sapiens	64-70
20657400-1	2010	Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.	Lysine	9-12	transient receptor potential cation channel subfamily V member 1	Homo sapiens	196-201
20406803-6	2010	Its binding site was mapped to Rev residues Lys-20 and Tyr-23 located in the N-terminal alpha-helical multimerization domain.	Lysine	44-47	Rev	Human immunodeficiency virus 1	31-34
20613843-6	2010	Whereas the interaction with H3 is promoted by acetylation at lysine 14, it is inhibited by methylation at lysine 4, and these opposing influences are important during transcriptional activation of the mouse DPF3b target genes Pitx2 and Jmjd1c.	Lysine	62-68	paired-like homeodomain transcription factor 2	Mus musculus	227-232
20613843-6	2010	Whereas the interaction with H3 is promoted by acetylation at lysine 14, it is inhibited by methylation at lysine 4, and these opposing influences are important during transcriptional activation of the mouse DPF3b target genes Pitx2 and Jmjd1c.	Lysine	107-113	paired-like homeodomain transcription factor 2	Mus musculus	227-232
20303335-4	2010	Solid-phase synthesis of cRGDyK (Arg-Gly-Asp-(D)Tyr-Lys) peptide and FAM-conjugated peptide were employed for binding to integrin alpha v beta 3.	Lysine	52-55	integrin subunit alpha V	Rattus norvegicus	121-137
20595511-2	2010	The first clinical trials demonstrated that GLP-1 receptor SPECT/CT using [Lys(40)(Ahx [6-aminohexanoic acid]-DOTA-(111)In)NH(2)]-exendin-4 can localize hardly detectable insulinomas.	Lysine	75-78	glucagon like peptide 1 receptor	Homo sapiens	44-49
19774489-8	2010	This data supports the concept that the conserved lysine cluster in murine SRA-II is the binding region for AcLDL or contributes to the trimeric structure of SRA-II necessary for AcLDL binding.	Lysine	50-56	macrophage scavenger receptor 1	Mus musculus	75-81
19774489-8	2010	This data supports the concept that the conserved lysine cluster in murine SRA-II is the binding region for AcLDL or contributes to the trimeric structure of SRA-II necessary for AcLDL binding.	Lysine	50-56	macrophage scavenger receptor 1	Mus musculus	158-164
20156182-0	2010	Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors.	Lysine	63-71	alanyl aminopeptidase, membrane	Homo sapiens	87-103
20156182-0	2010	Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors.	Lysine	63-71	alanyl aminopeptidase, membrane	Homo sapiens	104-108
20156182-1	2010	A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized.	Lysine	17-25	alanyl aminopeptidase, membrane	Homo sapiens	41-57
20156182-1	2010	A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized.	Lysine	17-25	alanyl aminopeptidase, membrane	Homo sapiens	59-62
20481588-9	2010	Thus, the methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and we suggest designating the yeast enzyme Ntm1 and the human enzyme NTMT1.	Lysine	88-91	N-terminal protein methyltransferase	Saccharomyces cerevisiae S288C	152-156
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Lysine	9-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	98-103
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Lysine	9-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	143-148
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Lysine	9-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	149-152
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Lysine	9-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	143-148
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Lysine	9-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	335-338
20512922-0	2010	PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression.	Lysine	47-53	lysine methyltransferase 5A	Homo sapiens	0-7
20093159-2	2010	For this purpose, we modified the GLP-1 analog of exendin-4 using two fatty acids (FA) either lauric acid (LUA, C12) or palmitic acid (PAA, C16) at its two lysine residues, to produce; Lys(12)-FA-Exendin-4 (FA-M2), Lys(27)-FA-Exendin-4 (FA-M1), or Lys(12,27)-diBA-Exendin-4 (FA-Di).	Lysine	156-162	glucagon	Mus musculus	34-39
20093159-2	2010	For this purpose, we modified the GLP-1 analog of exendin-4 using two fatty acids (FA) either lauric acid (LUA, C12) or palmitic acid (PAA, C16) at its two lysine residues, to produce; Lys(12)-FA-Exendin-4 (FA-M2), Lys(27)-FA-Exendin-4 (FA-M1), or Lys(12,27)-diBA-Exendin-4 (FA-Di).	Lysine	185-188	glucagon	Mus musculus	34-39
20093159-2	2010	For this purpose, we modified the GLP-1 analog of exendin-4 using two fatty acids (FA) either lauric acid (LUA, C12) or palmitic acid (PAA, C16) at its two lysine residues, to produce; Lys(12)-FA-Exendin-4 (FA-M2), Lys(27)-FA-Exendin-4 (FA-M1), or Lys(12,27)-diBA-Exendin-4 (FA-Di).	Lysine	215-218	glucagon	Mus musculus	34-39
20093159-2	2010	For this purpose, we modified the GLP-1 analog of exendin-4 using two fatty acids (FA) either lauric acid (LUA, C12) or palmitic acid (PAA, C16) at its two lysine residues, to produce; Lys(12)-FA-Exendin-4 (FA-M2), Lys(27)-FA-Exendin-4 (FA-M1), or Lys(12,27)-diBA-Exendin-4 (FA-Di).	Lysine	215-218	glucagon	Mus musculus	34-39
20567762-1	2010	Methylation of lysine residues, catalyzed by histone methyltransferase (HMT) enzymes, is one of many modifications of core histone proteins that regulate transcription and chromatin structure.	Lysine	15-21	PR/SET domain 9	Homo sapiens	72-75
20501910-4	2010	Metabolic profiling and isotope tracer experimentation revealed that isovaleryl-CoA dehydrogenase is involved in degradation of the branched-chain amino acids, phytol, and Lys, while 2-hydroxyglutarate dehydrogenase is involved exclusively in Lys degradation.	Lysine	172-175	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	69-97
20501910-4	2010	Metabolic profiling and isotope tracer experimentation revealed that isovaleryl-CoA dehydrogenase is involved in degradation of the branched-chain amino acids, phytol, and Lys, while 2-hydroxyglutarate dehydrogenase is involved exclusively in Lys degradation.	Lysine	243-246	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	69-97
20501910-7	2010	Our results aid in the elucidation of the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route.	Lysine	59-62	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	100-128
20216989-1	2010	The thrombin-activatable fibrinolysis inhibitor (TAFI) is a key mediator in the regulation of endogenous fibrinolysis, down-regulating clot lysis by degrading the C-terminal lysine residues from fibrin, which are important for binding and activating plasminogen.	Lysine	174-180	carboxypeptidase B2	Homo sapiens	4-47
20216989-1	2010	The thrombin-activatable fibrinolysis inhibitor (TAFI) is a key mediator in the regulation of endogenous fibrinolysis, down-regulating clot lysis by degrading the C-terminal lysine residues from fibrin, which are important for binding and activating plasminogen.	Lysine	174-180	carboxypeptidase B2	Homo sapiens	49-53
20139424-1	2010	Set2-mediated H3 Lys(36) methylation is a histone modification that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histone deacetylase complex to repress intragenic cryptic transcription.	Lysine	17-20	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-4
20139424-2	2010	Recently, we identified a trans-histone pathway in which the interaction between the N terminus of Set2 and histone H4 Lys(44) is needed to mediate trans-histone H3 Lys(36) di- and trimethylation.	Lysine	119-122	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	99-103
20139424-2	2010	Recently, we identified a trans-histone pathway in which the interaction between the N terminus of Set2 and histone H4 Lys(44) is needed to mediate trans-histone H3 Lys(36) di- and trimethylation.	Lysine	165-168	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	99-103
20139424-3	2010	In the current study, we demonstrate that mutation of the lysine 44 residue in histone H4 or the Set2 mutant lacking the histone H4 interaction motif leads to intragenic cryptic transcripts, indicating that the Set2 and histone H4 interaction is important to repress intragenic cryptic transcription.	Lysine	58-64	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	211-215
19369050-2	2010	Biotinylation of lysine (K) residues in histones, mediated by holocarboxylase synthetase (HCS), is a novel diet-dependent mechanism to regulate chromatin structure and gene expression.	Lysine	17-23	holocarboxylase synthetase	Homo sapiens	62-88
19369050-2	2010	Biotinylation of lysine (K) residues in histones, mediated by holocarboxylase synthetase (HCS), is a novel diet-dependent mechanism to regulate chromatin structure and gene expression.	Lysine	17-23	holocarboxylase synthetase	Homo sapiens	90-93
20071582-10	2010	Our results indicate that Thr-170 phosphorylation and TRIM25-mediated Lys-172 ubiquitination of RIG-I functionally antagonize each other.	Lysine	70-73	tripartite motif containing 25	Homo sapiens	54-60
20226045-6	2010	Replication analysis of HIV-1 clones carrying substitutions at the IN lysines acetylated by both GCN5 and p300, or exclusively by GCN5, demonstrated that these residues are required for efficient viral integration.	Lysine	70-77	E1A binding protein p300	Homo sapiens	106-110
20226045-7	2010	In addition, a comparative analysis of the replication efficiencies of the IN triple- and quadruple-mutant viruses revealed that even though the lysines targeted by both GCN5 and p300 are required for efficient virus integration, the residue exclusively modified by GCN5 (K258) does not affect this process.	Lysine	145-152	E1A binding protein p300	Homo sapiens	179-183
16783012-4	2006	This substitution appears to abolish all DNA damage-tolerance activities normally carried out by the RAD6/RAD18 pathway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-dependent component of this pathway, but has little effect on the growth rate, suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA.	Lysine	372-378	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	386-390
16720573-2	2006	Here, we have shown that eIF4E is ubiquitinated primarily at Lys-159 and incubation of cells with a proteasome inhibitor leads to increased eIF4E levels, suggesting the proteasome-dependent proteolysis of ubiquitinated eIF4E.	Lysine	61-64	eukaryotic translation initiation factor 4E	Homo sapiens	25-30
16763550-4	2006	However, functional Ring1b is recruited by Xist and mediates ubiquitination of histone H2A in Eed deficient embryonic stem (ES) cells, which lack histone H3 lysine 27 tri-methylation.	Lysine	157-163	ring finger protein 2	Homo sapiens	20-26
16728974-0	2006	ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.	Lysine	33-39	inhibitor of growth family member 2	Homo sapiens	0-4
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	toll-like receptor 2	Mus musculus	63-67
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	colony stimulating factor 3 (granulocyte)	Mus musculus	256-260
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	chemokine (C-X-C motif) ligand 15	Mus musculus	266-269
16772434-2	2006	Evidence exists that distinct lysine residues in histones are modified by covalent attachment of the vitamin biotin, catalyzed by biotinidase and holocarboxylase synthetase.	Lysine	30-36	biotinidase	Homo sapiens	130-172
16839343-2	2006	Previously, we have demonstrated that region Glu(1811)-Lys(1818) within FVIII light chain constitutes an important binding region for this receptor.	Lysine	55-58	coagulation factor VIII	Homo sapiens	72-77
16789823-4	2006	In yeast, there is evidence for a second, error-free, pathway that requires modification of PCNA with non-proteolytic lysine 63-linked polyubiquitin (K63-polyUb) chains.	Lysine	118-124	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	92-96
16630631-6	2006	Biochemical characterization of autoacetylated CheY and mass spectrometry analysis of its tryptic digests revealed that its acetylated lysine residues are those found in CheY acetylated by Acs, but the acetylation-level distribution among the acetylation sites was different.	Lysine	135-141	acyl-CoA synthetase short chain family member 2	Homo sapiens	189-192
16639733-8	2006	An elevation of the risk for ESCC was pronounced most among carriers of ALDH2 Lys/Lys and XRCC1 399Gln/Gln or Gln/Arg who consumed a low level of dietary selenium (adjusted OR, 4.16; 95% CI, 1.14-15.12).	Lysine	78-81	aldehyde dehydrogenase 2 family member	Homo sapiens	72-77
16732283-4	2006	X-ray structures for wild-type and mutant human Ubc9-RanGAP1 complexes showed partial loss of contacts to the substrate lysine in mutant complexes.	Lysine	120-126	ubiquitin conjugating enzyme E2 I	Homo sapiens	48-52
16732283-7	2006	It seems that Ubc9 uses an indirect mechanism to activate lysine for conjugation that may be conserved among E2 family members.	Lysine	58-64	ubiquitin conjugating enzyme E2 I	Homo sapiens	14-18
16707785-8	2006	Site-directed mutagenesis studies identified involvement of cysteine 61 and lysine 133, located in the extracellular domain of the ASIC1a subunit, in the modulation of ASICs by oxidizing and reducing agents, respectively.	Lysine	76-82	acid-sensing (proton-gated) ion channel 1	Mus musculus	131-137
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Lysine	20-23	aldehyde dehydrogenase 2 family member	Homo sapiens	14-19
16611979-1	2006	Despite recent advances in characterizing the regulation of histone H3 lysine 4 (H3-K4) methylation at the GAL1 gene by the H2B-K123-specific deubiquitinase activity of Saccharomyces cerevisiae SAGA (Spt-Ada-Gcn5-acetyltransferase)-associated Ubp8p, our knowledge on the general role of Ubp8p at the SAGA-dependent genes is lacking.	Lysine	71-77	galactokinase	Saccharomyces cerevisiae S288C	107-111
16623599-4	2006	In contrast, a high degree of specificity for the basic side chain could be observed because the KIR-DAP12 and FcalphaRI-Fcgamma interactions favored lysine or arginine, respectively.	Lysine	150-156	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	97-100
16109483-0	2006	Lysine residues in N-terminal and C-terminal regions of human histone H2A are targets for biotinylation by biotinidase.	Lysine	0-6	biotinidase	Homo sapiens	107-118
16594917-0	2006	Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract.	Lysine	111-117	matrix metallopeptidase 2	Homo sapiens	14-40
16581765-6	2006	Based on these observations, we propose that Keap1 recruits Nrf2 by the ETGE motif and that the DLG motif of the Neh2 domain locks its lysine-rich central alpha-helix in a correct position to benefit ubiquitin signaling.	Lysine	135-141	nei like DNA glycosylase 2	Homo sapiens	113-117
16428803-5	2006	Systematic analysis has identified a single major SUMO1 conjugation site located between amino acid residues 110 and 125 that contains a single lysine residue at 117 (Lys-117).	Lysine	144-150	small ubiquitin like modifier 1	Homo sapiens	50-55
16428803-5	2006	Systematic analysis has identified a single major SUMO1 conjugation site located between amino acid residues 110 and 125 that contains a single lysine residue at 117 (Lys-117).	Lysine	167-170	small ubiquitin like modifier 1	Homo sapiens	50-55
16428803-6	2006	Using a short peptide spanning this region, we showed that a poly-SUMO1 chain was assembled in this peptide at Lys-117.	Lysine	111-114	small ubiquitin like modifier 1	Homo sapiens	66-71
16537506-2	2006	CENP-A nucleosomes are interspersed with nucleosomes containing histone H3 dimethylated at lysine 4, distinguishing centromeric chromatin (CEN chromatin) from flanking heterochromatin that is defined by H3 lysine 9 methylation.	Lysine	206-212	centromere protein A	Homo sapiens	0-6
16484498-3	2006	A transcriptional repressor form of MEF2A that is sumoylated at lysine-403 promoted dendritic claw differentiation.	Lysine	64-70	myocyte enhancer factor 2A	Homo sapiens	36-41
16484498-4	2006	Activity-dependent calcium signaling induced a calcineurin-mediated dephosphorylation of MEF2A at serine-408 and, thereby, promoted a switch from sumoylation to acetylation at lysine-403, which led to inhibition of dendritic claw differentiation.	Lysine	176-182	myocyte enhancer factor 2A	Homo sapiens	89-94
16387461-9	2006	Urinary levels of acrolein (ACR)-lysine adduct increased significantly with age in SAMP1 mice; however, CoQH2 had no effect.	Lysine	33-39	transmembrane protein 201	Mus musculus	83-88
16291740-2	2006	Upon p53 activation, however, these lysines become acetylated by p300/CREB-binding protein.	Lysine	36-43	E1A binding protein p300	Homo sapiens	65-69
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Lysine	298-301	endothelin receptor type A	Homo sapiens	47-52
16399501-4	2006	Upon sterol deprivation, the Scap/SREBP complex dissociates from Insig-1, which is then ubiquitinated on lysines 156 and 158 and degraded in proteasomes.	Lysine	105-112	SREBF chaperone	Homo sapiens	29-33
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	96-99	RB transcriptional corepressor 1	Homo sapiens	64-67
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	103-106	RB transcriptional corepressor 1	Homo sapiens	64-67
17020914-5	2006	Furthermore, our findings suggested that PIAS3 strongly induced PRB sumoylation at three sites, Lys-7, Lys-388 and Lys-531.	Lysine	103-106	RB transcriptional corepressor 1	Homo sapiens	64-67
16227211-5	2005	Site-directed mutagenesis of Synechococcus KaiB confirmed that alanine substitution of residues Lys-11 or Lys-43 in the cleft, or deletion of C-terminal residues 95-108, which forms part of the ridges, strongly weakens in vivo circadian rhythms.	Lysine	96-99	kaiB	Thermosynechococcus elongatus BP-1	43-47
16227211-5	2005	Site-directed mutagenesis of Synechococcus KaiB confirmed that alanine substitution of residues Lys-11 or Lys-43 in the cleft, or deletion of C-terminal residues 95-108, which forms part of the ridges, strongly weakens in vivo circadian rhythms.	Lysine	106-109	kaiB	Thermosynechococcus elongatus BP-1	43-47
16372014-8	2005	We show that the human CHD1 double chromodomains target the lysine 4-methylated histone H3 tail (H3K4me), a hallmark of active chromatin.	Lysine	60-66	chromodomain helicase DNA binding protein 1	Homo sapiens	23-27
16344309-3	2005	Xenopus laevis PCNA is modified on lysine 164 by sumoylation, monoubiquitylation, and diubiquitylation.	Lysine	35-41	proliferating cell nuclear antigen S homeolog	Xenopus laevis	15-19
16344309-5	2005	When lysine 164 modification is prevented, replication fork movement through undamaged DNA slows down and DNA polymerase delta fails to associate with replicating chromatin.	Lysine	5-11	polymerase (DNA directed), delta 1, catalytic subunit L homeolog	Xenopus laevis	106-126
16207715-5	2005	In vivo sumoylation assays confirmed that lysines 244, 263, and 353 of PLAG1 and lysines 250, 269, and 356 of PLAGL2 are indeed sumoylation sites.	Lysine	42-49	PLAG1 like zinc finger 2	Homo sapiens	110-116
16207715-5	2005	In vivo sumoylation assays confirmed that lysines 244, 263, and 353 of PLAG1 and lysines 250, 269, and 356 of PLAGL2 are indeed sumoylation sites.	Lysine	81-88	PLAG1 like zinc finger 2	Homo sapiens	110-116
16207715-10	2005	Interestingly, the sumoylation-deficient mutant of PLAGL2 is acetylated at a lower level than its wild-type counterpart, suggesting that some of the lysine residues may be targets for both modifications.	Lysine	149-155	PLAG1 like zinc finger 2	Homo sapiens	51-57
16207715-11	2005	Finally, mutation of three lysine residues in sumoylation motifs significantly impairs the transformation ability of PLAG1 and PLAGL2, suggesting the essential roles of these sites in the oncogenic potential of PLAG proteins.	Lysine	27-33	PLAG1 like zinc finger 2	Homo sapiens	127-133
16246290-0	2005	Synthesis and study of the electrophoretic behavior of mannan conjugates with cyclic peptide analogue of myelin basic protein using lysine-glycine linker.	Lysine	132-138	myelin basic protein	Homo sapiens	105-125
16316974-5	2005	Mutating the glycines at the equivalent sites to lysines also rendered weak inward rectifier Kir1.1 channels more inwardly rectifying.	Lysine	49-56	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	93-99
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Lysine	170-176	estrogen related receptor gamma	Homo sapiens	49-76
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Lysine	170-176	estrogen related receptor gamma	Homo sapiens	78-82
16326832-7	2005	Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators.	Lysine	170-176	estrogen related receptor gamma	Homo sapiens	228-232
16287840-4	2005	We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain.	Lysine	193-199	E1A binding protein p300	Homo sapiens	13-17
15782282-10	2005	Logistic regression analysis revealed that the OPG genotype Lys-Lys had a 2.7 times (95% CI: 0.83-9.11) greater risk for osteopenia/osteoporosis than the Asn-Asn genotype.	Lysine	60-63	TNF receptor superfamily member 11b	Homo sapiens	47-50
16300411-2	2005	Trappin-2 has unique conserved sequence motifs rich in Gln and Lys residues.	Lysine	63-66	peptidase inhibitor 3	Homo sapiens	0-9
16287980-2	2005	Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine residues 999, 1034, and 1057 both in vitro and in vivo.	Lysine	192-198	small ubiquitin like modifier 1	Homo sapiens	182-188
16135513-0	2005	Role of an S4-S5 linker lysine in the trafficking of the Ca(2+)-activated K(+) channels IK1 and SK3.	Lysine	24-30	potassium calcium-activated channel subfamily N member 3	Rattus norvegicus	96-99
16135513-2	2005	We demonstrate that a lysine residue (Lys(197)) located on the intracellular loop between the S4 and S5 domains is necessary for the correct trafficking of hIK1 to the plasma membrane.	Lysine	22-28	potassium calcium-activated channel subfamily N member 4	Homo sapiens	156-160
16135513-2	2005	We demonstrate that a lysine residue (Lys(197)) located on the intracellular loop between the S4 and S5 domains is necessary for the correct trafficking of hIK1 to the plasma membrane.	Lysine	38-41	potassium calcium-activated channel subfamily N member 4	Homo sapiens	156-160
16135513-7	2005	Finally, mutation of this conserved lysine in rat SK3 similarly resulted in a channel that failed to correctly traffic to the plasma membrane.	Lysine	36-42	potassium calcium-activated channel subfamily N member 3	Rattus norvegicus	50-53
15944210-6	2005	Furthermore, CaMKII was rapidly and robustly activated in VSM cells plated on poly-l-lysine.	Lysine	78-91	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	13-19
16237033-5	2005	New genes were identified in both pathways, including the davB and davA genes that encode the enzymes involved in the oxidation of L-lysine to delta-aminovaleramide and the hydrolysis of the latter to delta-aminovalerate, respectively.	Lysine	131-139	FAD-dependent oxidoreductase	Pseudomonas putida KT2440	58-62
16095647-2	2005	In the present study, we investigated the role(s) of the protein kinase activity of UL13 in viral replication using a recombinant virus expressing enzymatically inactive UL13 after an amino acid substitution in the invariant lysine of UL13.	Lysine	225-231	tegument serine/threonine protein kinase	Human alphaherpesvirus 1	84-88
16126174-0	2005	Six lysine residues on c-Myc are direct substrates for acetylation by p300.	Lysine	4-10	E1A binding protein p300	Homo sapiens	70-74
16126174-6	2005	These analyses identify six lysine residues in human Myc (K143, K157, K275, K317, K323, and K371) as direct substrates for p300.	Lysine	28-34	E1A binding protein p300	Homo sapiens	123-127
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	96-99	plasminogen	Homo sapiens	0-7
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	96-99	syndecan 4	Homo sapiens	46-56
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	118-121	plasminogen	Homo sapiens	0-7
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Lysine	118-121	syndecan 4	Homo sapiens	46-56
16194093-7	2005	Six sites of in vitro SUMOylation in RanBP2 along with four branch-point lysines in SUMO-1 and three in SUMO-2 were identified.	Lysine	73-80	small ubiquitin like modifier 1	Homo sapiens	84-90
16142216-7	2005	However, SUMO-1 failed to interact with ASK 1(3M) and to suppress ASK 1(3M) activation, indicating that the three lysines are important for regulation by SUMO-1.	Lysine	114-121	small ubiquitin like modifier 1	Homo sapiens	154-160
16166626-3	2005	Mutations that affect Dot1 function such as Rad6-Bre1/Paf1 pathway gene deletions or mutation of H2B Lys 123 or H3 Lys 79 share dot1Delta checkpoint defects.	Lysine	101-104	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	49-53
16166628-0	2005	Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.	Lysine	76-82	myocyte enhancer factor 2A	Homo sapiens	14-18
16166628-6	2005	Importantly, HDAC4 promotes sumoylation on a lysine residue that is also subject to acetylation by a MEF2 coactivator, the acetyltransferase CBP, suggesting a possible interplay between acetylation and sumoylation in regulating MEF2 activity.	Lysine	45-51	myocyte enhancer factor 2A	Homo sapiens	101-105
16166628-6	2005	Importantly, HDAC4 promotes sumoylation on a lysine residue that is also subject to acetylation by a MEF2 coactivator, the acetyltransferase CBP, suggesting a possible interplay between acetylation and sumoylation in regulating MEF2 activity.	Lysine	45-51	myocyte enhancer factor 2A	Homo sapiens	228-232
16143104-6	2005	We find that Set1 is required for methylation of conserved lysines in a kinetochore protein, Dam1.	Lysine	59-66	Dam1p	Saccharomyces cerevisiae S288C	93-97
15890677-3	2005	In this report, we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro, and potently stimulates Foxo1-induced transcription of IGF-binding protein-1 in transient transfection experiments.	Lysine	70-77	E1A binding protein p300	Homo sapiens	45-49
15961394-7	2005	Meanwhile, chromatin immunoprecipitation showed higher basal and TSA-enhanced associations of ROCK1 promoter regions with Lys(9)-acetylated histone 3 in suspended cells than in fibronectin-adherent cells and expression of ROCK1 was higher and further increased by TSA treatment in suspension.	Lysine	122-125	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	94-99
15986205-3	2005	Trimethylation of histone H3 on lysine 27, mediated by a PcG protein complex consisting of Eed, Ezh2, and Suz12, is integral in differentiation, stem cell self-renewal, and tumorigenesis.	Lysine	32-38	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	106-111
16098147-6	2005	Mutational analysis showed that lysine residues at 499, 576, and 624 are the major acceptor sites for SUMO-1.	Lysine	32-38	small ubiquitin like modifier 1	Homo sapiens	102-108
16024812-0	2005	hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells.	Lysine	58-64	lysine acetyltransferase 8	Homo sapiens	0-4
16024812-10	2005	Taken together, our data show that hMOF is required for histone H4 lysine 16 acetylation in mammalian cells and suggest that hMOF has a role in DNA damage response during cell cycle progression.	Lysine	67-73	lysine acetyltransferase 8	Homo sapiens	35-39
16024812-10	2005	Taken together, our data show that hMOF is required for histone H4 lysine 16 acetylation in mammalian cells and suggest that hMOF has a role in DNA damage response during cell cycle progression.	Lysine	67-73	lysine acetyltransferase 8	Homo sapiens	125-129
16111893-4	2005	Acetylation of discrete lysine residues in RelA modulates distinct functions of NF-kappaB, including transcriptional activation, DNA binding, and assembly with its inhibitor IkappaBalpha.	Lysine	24-30	RELA proto-oncogene, NF-kB subunit	Homo sapiens	43-47
15774487-9	2005	The TAP2 codons 379 isoleucine carriers and LMP7 codons 145 lysine carriers were found to be more susceptible to esophageal carcinoma (OR = 2.74, 95% CI = 1.15-6.49, P = 0.023 for TAP2; OR = 2.19, 95% CI = 1.09-4.37, P = 0.027 for LMP7).	Lysine	60-66	proteasome 20S subunit beta 8	Homo sapiens	44-48
15917652-4	2005	The effects of p300 on E2F-1 ubiquitination require the integrity of the HAT domain of p300 and of the three acetylated lysines in E2F-1.	Lysine	120-127	E1A binding protein p300 S homeolog	Xenopus laevis	15-19
15917652-4	2005	The effects of p300 on E2F-1 ubiquitination require the integrity of the HAT domain of p300 and of the three acetylated lysines in E2F-1.	Lysine	120-127	E2F transcription factor 1 L homeolog	Xenopus laevis	23-28
15917652-4	2005	The effects of p300 on E2F-1 ubiquitination require the integrity of the HAT domain of p300 and of the three acetylated lysines in E2F-1.	Lysine	120-127	E2F transcription factor 1 L homeolog	Xenopus laevis	131-136
15978044-3	2005	Blocking the kringle 1 lysine-binding site with monoclonal antibody 34D3 fully abolished binding and activation of Glu-plasminogen and prevented both fibrinolysis and plasmin-induced cell detachment-induced apoptosis.	Lysine	23-29	plasminogen	Homo sapiens	119-126
15978044-7	2005	We conclude that Glu-/Lys-plasminogen and plasmin conformations are associated with transitions in the lysine-binding function of kringles 1 and 4 that modulate fibrinolysis and pericellular proteolysis and may be of biological relevance during athero-thrombosis and inflammatory states.	Lysine	103-109	plasminogen	Homo sapiens	26-33
15933069-2	2005	We present here the crystal structure of a ternary complex of the enzyme Pr-Set7 (also known as Set8) that methylates Lys 20 of histone H4 (H4-K20).	Lysine	118-121	lysine methyltransferase 5A	Homo sapiens	73-80
15831498-2	2005	We have recently demonstrated that the inhibitory Smad7 interacts with the acetyl transferase p300 and that p300 acetylates Smad7 on two lysine residues.	Lysine	137-143	E1A binding protein p300	Homo sapiens	108-112
19997087-6	2010	Mechanistically, Wwp2 catalyzes Oct4 poly-ubiquitination via the lysine 63 linkage in a dosage-dependent manner.	Lysine	65-71	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	17-21
19997087-6	2010	Mechanistically, Wwp2 catalyzes Oct4 poly-ubiquitination via the lysine 63 linkage in a dosage-dependent manner.	Lysine	65-71	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	32-36
20112895-3	2010	To facilitate this difficult task, PMK contains 17 arginines and eight lysines.	Lysine	71-78	phosphomevalonate kinase	Homo sapiens	35-38
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	0-6	mitogen-activated protein kinase kinase kinase 7	Mus musculus	39-43
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	47-53	mitogen-activated protein kinase kinase kinase 7	Mus musculus	39-43
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	49-52	mitogen-activated protein kinase kinase kinase 7	Mus musculus	64-68
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	95-98	mitogen-activated protein kinase kinase kinase 7	Mus musculus	64-68
20038579-3	2010	Tumor necrosis factor receptor-associated factors 2 and 6 (TRAF2 and -6) act as the ubiquitin E3 ligases to mediate Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue in vivo and in vitro.	Lysine	116-119	mitogen-activated protein kinase kinase kinase 7	Mus musculus	131-135
20038579-3	2010	Tumor necrosis factor receptor-associated factors 2 and 6 (TRAF2 and -6) act as the ubiquitin E3 ligases to mediate Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue in vivo and in vitro.	Lysine	162-165	mitogen-activated protein kinase kinase kinase 7	Mus musculus	131-135
20038579-4	2010	Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment.	Lysine	0-3	mitogen-activated protein kinase kinase kinase 7	Mus musculus	15-19
20038579-4	2010	Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment.	Lysine	0-3	mitogen-activated protein kinase kinase kinase 7	Mus musculus	79-83
20038579-4	2010	Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment.	Lysine	46-49	mitogen-activated protein kinase kinase kinase 7	Mus musculus	15-19
20038579-4	2010	Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment.	Lysine	46-49	mitogen-activated protein kinase kinase kinase 7	Mus musculus	79-83
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	30-33	mitogen-activated protein kinase kinase kinase 7	Mus musculus	67-71
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	75-78	mitogen-activated protein kinase kinase kinase 7	Mus musculus	67-71
15938724-1	2005	We describe haematological and DNA characterization of haemoglobinopathies in Thai adolescents caused by compound heterozygosities for Hb E [beta26(B8) Glu-Lys] and two other beta-globin chain variants, Hb Pyrgos [beta83(EF7) Gly-Asp] and Hb J Bangkok [beta56(D7) Gly-Asp].	Lysine	156-159	hemoglobin subunit epsilon 1	Homo sapiens	135-139
24300108-5	2014	We found that a low dose of ethanol induces mild neurodegeneration in P7 mice, enhances specific acetylation of H3 on lysine 14 (H3K14ace) at G9a exon1, G9a protein levels, augments the dimethylation of H3K9 and H3 lysine 27 (H3K27me2).	Lysine	118-124	euchromatic histone lysine N-methyltransferase 2	Mus musculus	142-145
15955067-5	2005	In Rv0386, the standard substrate, adenine-defining lysine-aspartate couple is replaced by glutamine-asparagine.	Lysine	52-58	transcriptional regulator	Mycobacterium tuberculosis H37Rv	3-9
24300108-5	2014	We found that a low dose of ethanol induces mild neurodegeneration in P7 mice, enhances specific acetylation of H3 on lysine 14 (H3K14ace) at G9a exon1, G9a protein levels, augments the dimethylation of H3K9 and H3 lysine 27 (H3K27me2).	Lysine	215-221	euchromatic histone lysine N-methyltransferase 2	Mus musculus	142-145
15782135-4	2005	We show here that, in contrast to other caspases such as caspase-9 and -3, caspase-8 can be sumoylated at lysine 156.	Lysine	106-112	caspase 8	Homo sapiens	75-84
20133625-1	2010	HYPB is a human histone H3 lysine 36 (H3K36)-specific methyltransferase and acts as the ortholog of yeast Set2.	Lysine	27-33	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-4
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Lysine	122-125	matrix metallopeptidase 2	Homo sapiens	7-11
20063892-1	2010	The histone acetyltransferase (HAT) p300/CBP has been shown to undergo autoacetylation on lysines in an apparent regulatory loop that stimulates HAT activity.	Lysine	90-97	E1A binding protein p300	Homo sapiens	36-40
16075932-7	2005	Genetic analysis revealed that TSC gene of the patient has a heterozygous C to A nucleotide substitution at position 545 in exon 4, which causes a threonine (Thr) to lysine (Lys) substitution at position 180.	Lysine	166-172	solute carrier family 12 member 3	Homo sapiens	31-34
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	241-244	E1A binding protein p300	Homo sapiens	61-65
16075932-7	2005	Genetic analysis revealed that TSC gene of the patient has a heterozygous C to A nucleotide substitution at position 545 in exon 4, which causes a threonine (Thr) to lysine (Lys) substitution at position 180.	Lysine	174-177	solute carrier family 12 member 3	Homo sapiens	31-34
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Lysine	122-125	matrix metallopeptidase 2	Homo sapiens	20-25
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	E1A binding protein p300	Homo sapiens	61-65
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	E1A binding protein p300	Homo sapiens	61-65
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	E1A binding protein p300	Homo sapiens	61-65
24297171-12	2014	More specifically, the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity.	Lysine	39-42	matrix metallopeptidase 2	Homo sapiens	75-80
24302725-0	2014	Acetylation at lysine 183 of progesterone receptor by p300 accelerates DNA binding kinetics and transactivation of direct target genes.	Lysine	15-21	progesterone receptor	Homo sapiens	29-50
15766567-0	2005	Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.	Lysine	85-91	small ubiquitin like modifier 1	Homo sapiens	75-81
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	plasminogen	Homo sapiens	30-41
19819898-8	2010	The dual characteristics of chymosin are due to the occurrence of polar/charged residues in the S1" subsite, such as Glu/Asp(289), Gln(298) and Lys/Gln(299), which are different from the S1" subsite of pepsin A.	Lysine	144-147	chymosin	Bos taurus	28-36
24302725-0	2014	Acetylation at lysine 183 of progesterone receptor by p300 accelerates DNA binding kinetics and transactivation of direct target genes.	Lysine	15-21	E1A binding protein p300	Homo sapiens	54-58
24302725-2	2014	This study reports the discovery by mass spectrometry of a novel progesterone receptor acetylation site at Lys-183 that is not in the consensus motif.	Lysine	107-110	progesterone receptor	Homo sapiens	65-86
15899702-3	2005	Cathepsin L, cathepsin K, plasmin, trypsin and tryptase were able to release elafin by cleaving the Lys 38 -Ala 39 peptide bond in trappin-2.	Lysine	100-103	plasminogen	Homo sapiens	26-33
24302725-3	2014	In vivo acetylation and mutagenesis experiments revealed that Lys-183 is a primary site of progesterone receptor (PR) acetylation.	Lysine	62-65	progesterone receptor	Homo sapiens	91-112
15899702-3	2005	Cathepsin L, cathepsin K, plasmin, trypsin and tryptase were able to release elafin by cleaving the Lys 38 -Ala 39 peptide bond in trappin-2.	Lysine	100-103	peptidase inhibitor 3	Homo sapiens	77-83
15899702-3	2005	Cathepsin L, cathepsin K, plasmin, trypsin and tryptase were able to release elafin by cleaving the Lys 38 -Ala 39 peptide bond in trappin-2.	Lysine	100-103	peptidase inhibitor 3	Homo sapiens	131-140
24302725-3	2014	In vivo acetylation and mutagenesis experiments revealed that Lys-183 is a primary site of progesterone receptor (PR) acetylation.	Lysine	62-65	progesterone receptor	Homo sapiens	114-116
15649887-4	2005	A major site of Stat3 that is acetylated by its coactivator, p300/CREB-binding protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.	Lysine	157-163	E1A binding protein p300	Homo sapiens	61-65
20098416-8	2010	Strikingly, we identified VDAC1 (voltage-dependent anion channel 1) as a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy.	Lysine	100-103	voltage dependent anion channel 1	Homo sapiens	26-31
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	0-3	E1A binding protein p300	Homo sapiens	35-39
20098416-8	2010	Strikingly, we identified VDAC1 (voltage-dependent anion channel 1) as a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy.	Lysine	100-103	voltage dependent anion channel 1	Homo sapiens	33-66
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	0-3	E1A binding protein p300	Homo sapiens	72-76
15632126-3	2005	We demonstrate that ubiquitination of histone H2B on lysine 123 by the Rad6-Bre1 complex, is necessary for activation of Rad53 kinase and cell cycle arrest.	Lysine	53-59	checkpoint kinase 2	Mus musculus	121-126
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	0-3	E1A binding protein p300	Homo sapiens	72-76
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	149-152	E1A binding protein p300	Homo sapiens	35-39
20000479-0	2010	Role of signature lysines in the deviant walker a motifs of the ArsA ATPase.	Lysine	18-25	arylsulfatase A	Homo sapiens	64-68
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	149-152	E1A binding protein p300	Homo sapiens	72-76
20000479-3	2010	ArsA has two signature lysines located at positions 16 and 335.	Lysine	23-30	arylsulfatase A	Homo sapiens	0-4
24302725-4	2014	Lys-183 acetylation is enhanced by p300 overexpression and abrogated by p300 gene silencing, suggesting that p300 is the major acetyltransferase for Lys-183 acetylation.	Lysine	149-152	E1A binding protein p300	Homo sapiens	72-76
20064247-5	2010	Chromatin immunoprecipitation (ChIP) experiments with an antibody raised against acetylated lysine 314 revealed that chromatin-bound p65 is indeed acetylated at lysine 314.	Lysine	92-98	RELA proto-oncogene, NF-kB subunit	Homo sapiens	133-136
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Lysine	47-53	SMAD family member 4	Homo sapiens	16-21
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Lysine	47-53	SMAD family member 4	Homo sapiens	103-108
20064247-5	2010	Chromatin immunoprecipitation (ChIP) experiments with an antibody raised against acetylated lysine 314 revealed that chromatin-bound p65 is indeed acetylated at lysine 314.	Lysine	161-167	RELA proto-oncogene, NF-kB subunit	Homo sapiens	133-136
24302725-5	2014	Furthermore, p300-mediated Lys-183 acetylation is associated with heightened PR activity.	Lysine	27-30	E1A binding protein p300	Homo sapiens	13-17
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Lysine	47-53	death domain associated protein	Homo sapiens	109-113
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Lysine	47-53	death domain associated protein	Homo sapiens	144-148
24324262-8	2014	In vitro, a region of USP37 harboring the three UIMs also bound to both Lys(48)-linked and Lys(63)-linked ubiquitin chains in a UIM2- and UIM3-dependent manner.	Lysine	72-75	ubiquitin specific peptidase 37	Homo sapiens	22-27
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Lysine	47-53	SMAD family member 4	Homo sapiens	103-108
15644311-3	2005	We observed that L31A or L31C mutations of PLB prevented the inhibition of Ca(2+)-ATPase activity and disabled the cross-linking of N27C and N30C of PLB to Lys(328) and Cys(318) of SERCA2a.	Lysine	156-159	phospholamban	Homo sapiens	43-46
20080798-0	2010	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.	Lysine	60-66	nuclear receptor binding SET domain protein 1	Homo sapiens	27-31
20080798-0	2010	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.	Lysine	60-66	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-85
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	RELA proto-oncogene, NF-kB subunit	Homo sapiens	98-101
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	nuclear receptor binding SET domain protein 1	Homo sapiens	150-206
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	nuclear receptor binding SET domain protein 1	Homo sapiens	208-212
15644311-3	2005	We observed that L31A or L31C mutations of PLB prevented the inhibition of Ca(2+)-ATPase activity and disabled the cross-linking of N27C and N30C of PLB to Lys(328) and Cys(318) of SERCA2a.	Lysine	156-159	phospholamban	Homo sapiens	149-152
24324262-8	2014	In vitro, a region of USP37 harboring the three UIMs also bound to both Lys(48)-linked and Lys(63)-linked ubiquitin chains in a UIM2- and UIM3-dependent manner.	Lysine	91-94	ubiquitin specific peptidase 37	Homo sapiens	22-27
15881673-10	2005	Mutation of two lysine residues greatly reduced the amount of the sumoylated form of OZF though their surrounding sequences differ from the consensus sequence reported for most proteins modified by SUMO-1 conjugation.	Lysine	16-22	small ubiquitin like modifier 1	Homo sapiens	198-204
24466302-2	2014	The E3 ubiquitin ligase, tripartite motif containing protein 25 (TRIM25), activates human RIG-I through generation of anchored K63-linked polyubiquitin chains attached to lysine 172, or alternatively, through the generation of unanchored K63-linked polyubiquitin chains that interact non-covalently with RIG-I CARD domains.	Lysine	171-177	tripartite motif containing 25	Homo sapiens	25-63
15881673-12	2005	Addition of zinc finger 7 restored SUMO-1 modification and UBC9 interaction and provides evidence that a region downstream of the target lysines is required for interaction with UBC9, in order to achieve SUMO-1 modification.	Lysine	137-144	small ubiquitin like modifier 1	Homo sapiens	204-210
15708348-7	2005	Overall, the ELISA data demonstrated that Lp(a) binding to laminin is mediated by apo(a) and a combination of the lysine analogue epsilon-aminocaproic acid and salt effectively decreases apo(a) binding to laminin.	Lysine	114-120	lipoprotein(a)	Homo sapiens	42-47
20108989-6	2010	The branched, 40 kDa PEG chain of peginterferon-alpha-2a is covalently attached via stable amide bonds to lysine residues of interferon-alpha-2a, and circulates as an intact molecule.	Lysine	106-112	interferon alpha 2	Homo sapiens	37-56
24466302-2	2014	The E3 ubiquitin ligase, tripartite motif containing protein 25 (TRIM25), activates human RIG-I through generation of anchored K63-linked polyubiquitin chains attached to lysine 172, or alternatively, through the generation of unanchored K63-linked polyubiquitin chains that interact non-covalently with RIG-I CARD domains.	Lysine	171-177	tripartite motif containing 25	Homo sapiens	65-71
24448210-3	2014	As co-factors of Lingo-1 signaling (Nogo receptor (NgR), With No Lysine (K) (WNK1) and Myelin transcription factor 1 (Myt1)) have been implicated in the genetics of schizophrenia, we explored for the first time the role of Lingo-1 signaling pathways in this disorder.	Lysine	65-71	leucine rich repeat and Ig domain containing 1	Homo sapiens	17-24
20508833-5	2010	In the in vitro kinase assay, HIPK4 exhibits kinase activity and mutation of the conserved lysine 40 or aspartic acid 136 residue in its catalytic domain inactivates its kinase function.	Lysine	91-97	homeodomain interacting protein kinase 4	Homo sapiens	30-35
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	Lysine	142-144	mitogen activated protein kinase 3	Rattus norvegicus	51-58
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	Lysine	142-144	mitogen activated protein kinase kinase 1	Rattus norvegicus	159-166
24448210-3	2014	As co-factors of Lingo-1 signaling (Nogo receptor (NgR), With No Lysine (K) (WNK1) and Myelin transcription factor 1 (Myt1)) have been implicated in the genetics of schizophrenia, we explored for the first time the role of Lingo-1 signaling pathways in this disorder.	Lysine	65-71	WNK lysine deficient protein kinase 1	Homo sapiens	77-81
20229688-4	2010	Once generated, TAFI down-regulates fibrinolysis by removing C-terminal lysine residues from partially degraded fibrin; thereby preventing the upregulation of plasminogen binding and activation.	Lysine	72-78	carboxypeptidase B2	Homo sapiens	16-20
24309115-4	2014	We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation.	Lysine	17-23	small ubiquitin like modifier 1	Homo sapiens	75-81
20018718-5	2009	We also demonstrate that the epigenetic inactivation of NSD1 in transformed cells leads to the specifically diminished methylation of the histone lysine residues H4-K20 and H3-K36.	Lysine	146-152	nuclear receptor binding SET domain protein 1	Homo sapiens	56-60
15574875-5	2005	A liposome-binding assay revealed that Sla2p binds to PtdIns(4,5)P2 specifically through its ANTH domain and identified specific lysine residues required for this interaction.	Lysine	129-135	Sla2p	Saccharomyces cerevisiae S288C	39-44
23017017-5	2014	Modafinil (300 mg/kg, intraperitoneal) inhibited reinstated cocaine seeking (but did not alter extinction responding by itself), and this effect was prevented by pre-treatment with bilateral microinjections of the mGluR2/3 antagonist LY-341495 (LY) into nucleus accumbens core.	Lysine	234-236	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	214-220
15748426-8	2005	As(2)O(3) binds ubiquitin like SUMO-1 through the lysine 160 of PML, resulting in the degradation of PML-RAR alpha.	Lysine	50-56	small ubiquitin like modifier 1	Homo sapiens	31-37
25030758-3	2014	One of these genes is called interferon stimulated gene 15 (ISG15), which encodes a ubiquitin homolog with a C-terminal Gly that becomes covalently attached to Lys residues on targeted proteins through an ATP-dependent multi-step enzymatic reaction called ISGylation.	Lysine	160-163	ISG15 ubiquitin like modifier	Homo sapiens	29-58
15580297-7	2005	Ubc9 and PIAS1 stimulate sumoylation in vivo of lysine 162 in the NID.	Lysine	48-54	ubiquitin conjugating enzyme E2 I	Homo sapiens	0-4
19767775-0	2009	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.	Lysine	0-6	cyclin D1	Homo sapiens	28-37
19767775-0	2009	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.	Lysine	0-6	F-box protein 4	Homo sapiens	64-68
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	cyclin D1	Homo sapiens	61-70
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	F-box protein 4	Homo sapiens	115-119
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	cyclin D1	Homo sapiens	207-216
19767775-4	2009	The work described herein reveals a requisite role for Lys-269 (K269) for the rapid polyubiquitin-mediated degradation of cyclin D1.	Lysine	55-58	cyclin D1	Homo sapiens	122-131
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	92-101
15628859-11	2005	Lys(108) in the LC1 of the yAAC2 was found to be associated with binding of the transport substrates, and its -NH(3)(+) moiety, to be of importance for the transport function.	Lysine	0-3	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	27-32
25030758-3	2014	One of these genes is called interferon stimulated gene 15 (ISG15), which encodes a ubiquitin homolog with a C-terminal Gly that becomes covalently attached to Lys residues on targeted proteins through an ATP-dependent multi-step enzymatic reaction called ISGylation.	Lysine	160-163	ISG15 ubiquitin like modifier	Homo sapiens	60-65
23701550-6	2014	As eIF5A requires and essential and unique modification of a specific residue of lysine, changing it to hypusine, eIF5A is an interesting cellular target for anti-inflammatory treatment.	Lysine	81-87	eukaryotic translation initiation factor 5A	Mus musculus	3-8
16250899-3	2005	Attachment of single ubiquitin molecules, rather than ubiquitin chains, to one or multiple lysines of the cytoplasmic domains of many growth factor receptors, ion channels and other membrane transporters is sufficient to target these proteins to a complex sorting apparatus on the endosome.	Lysine	91-98	ubiquitin	Saccharomyces cerevisiae S288C	21-30
16250899-3	2005	Attachment of single ubiquitin molecules, rather than ubiquitin chains, to one or multiple lysines of the cytoplasmic domains of many growth factor receptors, ion channels and other membrane transporters is sufficient to target these proteins to a complex sorting apparatus on the endosome.	Lysine	91-98	ubiquitin	Saccharomyces cerevisiae S288C	54-63
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	123-132
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	123-132
19767775-7	2009	Strikingly, although mutation of lysine 269 to arginine inhibits cyclin D1 degradation, it does not inhibit cyclin D1 ubiquitylation in vivo, showing that ubiquitylation of a specific lysine can influence substrate targeting to the 26S proteasome.	Lysine	33-39	cyclin D1	Homo sapiens	65-74
23701550-6	2014	As eIF5A requires and essential and unique modification of a specific residue of lysine, changing it to hypusine, eIF5A is an interesting cellular target for anti-inflammatory treatment.	Lysine	81-87	eukaryotic translation initiation factor 5A	Mus musculus	114-119
19920177-6	2009	Based on this mono-ubiquitin moiety on RNAPII, an Elc1/Cul3 complex then produces a ubiquitin chain linked via lysine 48, which can trigger proteolysis.	Lysine	111-117	cullin 3	Homo sapiens	55-59
24826793-7	2014	This leads to a frameshift that modifies the C-terminal sequence to (40)Lys-Pro-Thr-Ser-Arg-Thr-Ser-Thr(47)COOH and the introduction of a stop codon TGA 23 nts downstream.	Lysine	72-75	T-box transcription factor 1	Homo sapiens	149-152
19801664-5	2009	Five amino acids known to be critical for rat FAAH activity are also conserved in AtFAAH (Lys-205, Ser-281, Ser-282, Ser-305, and Arg-307).	Lysine	90-93	fatty-acid amide hydrolase-like	Rattus norvegicus	46-50
16114185-1	2005	Hb E-Saskatoon [beta22(B4)Glu--&gt;Lys] does not cause any clinical symptoms in the heterozygous state.	Lysine	35-38	hemoglobin subunit epsilon 1	Homo sapiens	0-4
16114186-1	2005	A compound heterozygous state of Hb E [beta26(B8)Glu--&gt;Lys] with Hb Lepore is rare with very few cases reported in the literature.	Lysine	58-61	hemoglobin subunit epsilon 1	Homo sapiens	33-37
19801664-5	2009	Five amino acids known to be critical for rat FAAH activity are also conserved in AtFAAH (Lys-205, Ser-281, Ser-282, Ser-305, and Arg-307).	Lysine	90-93	fatty acid amide hydrolase	Arabidopsis thaliana	82-88
24117969-5	2014	Purified ADAM10 cleaved NCAM at a sequence within the E-F loop of the second fibronectin type III domain (Leu(671) -Lys(672) /Ser(673) -Leu(674) ) identified by mass spectrometry.	Lysine	116-119	ADAM metallopeptidase domain 10	Homo sapiens	9-15
15619673-3	2005	INTRODUCTION: We have recently shown that lysyl hydroxylase (LH) 2b, through its action on the telopeptidyl lysine residues of collagen, regulates collagen cross-linking pathway in the osteoblastic cell line, MC3T3-E1.	Lysine	108-114	LIM homeobox protein 9	Mus musculus	42-67
15619673-13	2005	CONCLUSIONS: These results indicate a critical role of LH2b catalyzed post-translational modification of collagen (i.e., telopeptidyl lysine hydroxylation and subsequent cross-linking) in collagen matrix formation and mineralization in bone.	Lysine	134-140	LIM homeobox protein 9	Mus musculus	55-59
19812216-7	2009	We hypothesize that HCS binds specifically to genomic regions rich in methylated cytosines and catalyzes increased biotinylation of histone H4 at lysine-12.	Lysine	146-152	holocarboxylase synthetase	Homo sapiens	20-23
23929215-1	2014	Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL) fusion protein-driven leukemias.	Lysine	79-86	delta/notch like EGF repeat containing	Homo sapiens	33-36
16303095-9	2005	These results also suggest that the heteromeric PGRP-LCa/LCx receptor complex recognizes monomeric Dap-type, but not Lys-type, PGN.	Lysine	117-120	Peptidoglycan recognition protein LC	Drosophila melanogaster	48-56
15715085-2	2005	Our laboratory previously demonstrated that huntingtin protein colocalizes with transglutaminase 2 and its product, the epsilon-(gamma-glutamyl)lysine bond in intranuclear inclusions in HD frontal cortex.	Lysine	144-150	huntingtin	Homo sapiens	44-54
19683575-3	2009	This sequence of events required both interaction of plasminogen with carboxy-terminal lysine residues and the proteolytic activity of plasmin.	Lysine	87-93	plasminogen	Homo sapiens	53-60
25462059-5	2014	Moreover, the degree to which a mimic mitigated the sod1Delta auxotrophic phenotype for lysine relative to its auxotrophic phenotype for methionine depended upon its level of lipophilicity-dependent accumulation inside the mitochondria.	Lysine	88-94	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	52-56
19759018-8	2009	A point mutation of the highly conserved lysine residue in the helicase domain, although retaining the wild type level of annealing activity, inactivated ATPase and helicase activities and eliminated stable complex formation.	Lysine	41-47	Helicase	Drosophila melanogaster	63-71
19759018-8	2009	A point mutation of the highly conserved lysine residue in the helicase domain, although retaining the wild type level of annealing activity, inactivated ATPase and helicase activities and eliminated stable complex formation.	Lysine	41-47	Helicase	Drosophila melanogaster	165-173
15694695-9	2005	Thirdly, due to critically functional lysine residues, we underscore the vulnerability to glycation of ornithine decarboxylase, the main enzyme in spermine biosynthesis.	Lysine	38-44	ornithine decarboxylase 1	Homo sapiens	103-126
15840963-1	2005	CPR has the carboxypeptidase B-like activity that can inactivate the inflammatory peptides such as C5a by removing the C-terminal arginine and can interfere with fibrinolysis by removing C-terminal lysine residue of fibrin.	Lysine	198-204	carboxypeptidase B1 (tissue)	Mus musculus	12-30
24217250-4	2013	A commonly occurring single nucleotide polymorphism (SNP) in human langerin results in change of one of these lysine residues, Lys-313, to isoleucine.	Lysine	110-116	CD207 molecule	Homo sapiens	67-75
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	nuclear receptor subfamily 1 group H member 4	Homo sapiens	168-171
24352422-2	2013	PRC2 catalyzes methylation of histone H3 at Lys 27 (H3K27me3) through its Enhancer of zeste (Ezh) constituent, of which there are two mammalian homologs: Ezh1 and Ezh2.	Lysine	44-47	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	154-158
20368827-8	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Lysine	134-140	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
15494368-5	2004	Mutant peptide derivatives that have lost a cluster of lysine in the vicinity of the transmembrane domain had reduced binding activity to Ret2p and the GMT with this sequence was delivered to the vacuole.	Lysine	55-61	GDP-mannose transporter	Saccharomyces cerevisiae S288C	152-155
15494368-6	2004	Our results indicate that GMT escapes from delivery to the vacuole by recycling to the endoplasmic reticulum and retrieval requires the lysine-rich C-terminal tail that can bind to the COPI coat.	Lysine	136-142	GDP-mannose transporter	Saccharomyces cerevisiae S288C	26-29
19817405-2	2009	METHOD: A novel lactam bridge-cyclized alpha-MSH peptide, Ac-GluGlu-CycMSH[DOTA] {Ac-Glu-Glu-c[Lys-Nle-Glu-His-DPhe-Arg-Trp-Gly-Arg-Pro-Val-Lys(DOTA)]}, was synthesized using standard 9-fluorenylmethyloxycarbonyl (Fmoc) chemistry.	Lysine	95-98	pro-opiomelanocortin-alpha	Mus musculus	39-48
19817405-2	2009	METHOD: A novel lactam bridge-cyclized alpha-MSH peptide, Ac-GluGlu-CycMSH[DOTA] {Ac-Glu-Glu-c[Lys-Nle-Glu-His-DPhe-Arg-Trp-Gly-Arg-Pro-Val-Lys(DOTA)]}, was synthesized using standard 9-fluorenylmethyloxycarbonyl (Fmoc) chemistry.	Lysine	140-143	pro-opiomelanocortin-alpha	Mus musculus	39-48
24349540-6	2013	We further characterised BET-1 and showed that it can physically associate with SMO-1 and UBC-9, and that it can be sumoylated in vitro within the second bromodomain at lysine 252.	Lysine	169-175	Bromodomain-containing protein bet-1	Caenorhabditis elegans	25-30
19737896-4	2009	Lys-for-Arg replacements in Crp4 attenuated bactericidal activity and slowed the kinetics of Escherichia coli ML35 cell permeabilization, and (R/K)-Crp4 required longer exposure times to reduce E. coli cell survival.	Lysine	0-3	defensin, alpha, 4	Mus musculus	28-32
19737896-6	2009	Therefore, Arg--&gt;Lys substitutions attenuated activity in Crp4 but not in RMAD-4, and the functional consequences of Arg--&gt;Lys replacements in alpha-defensins are dependent on the peptide primary structure.	Lysine	20-23	defensin, alpha, 4	Mus musculus	61-65
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	199-202	complement C4B (Chido blood group)	Homo sapiens	87-90
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	complement C4B (Chido blood group)	Homo sapiens	87-90
20023241-4	2009	A single nucleotide polymorphism K167N (G501C) of the LOX-1 gene results in an amino acid dimorphism (Lys/Asn) at residue 167.	Lysine	102-105	oxidized low density lipoprotein receptor 1	Homo sapiens	54-59
23891857-1	2013	Plasma membrane expression (PME) of the human GnRHR (hGnRHR) is regulated by a primate-specific Lys(191) which destabilizes a Cys(14)-Cys(200) bridge required by the cellular quality control system (QCS).	Lysine	96-99	gonadotropin releasing hormone receptor	Homo sapiens	46-51
19918361-5	2009	SLY protein colocalizes with the X and Y chromatin in spermatids of normal males, and Sly deficiency leads to defective repressive marks on the sex chromatin, such as reduced levels of the heterochromatin protein CBX1 and of histone H3 methylated at lysine 9.	Lysine	250-256	Sycp3 like Y-linked	Mus musculus	0-3
15448640-6	2004	Moreover, repressed regions are trimethylated at lysines 9 and 27, suggesting that these histone modifications represent a mark for inactive PcG-controlled regions.	Lysine	49-56	Polycomb	Drosophila melanogaster	141-144
15258251-0	2004	Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.	Lysine	17-23	Rho guanine nucleotide exchange factor 12	Homo sapiens	92-118
23891857-1	2013	Plasma membrane expression (PME) of the human GnRHR (hGnRHR) is regulated by a primate-specific Lys(191) which destabilizes a Cys(14)-Cys(200) bridge required by the cellular quality control system (QCS).	Lysine	96-99	gonadotropin releasing hormone receptor	Homo sapiens	53-59
15258251-7	2004	We found that lysine 204 of Galpha13 is important for interaction with the RGS domain of p115 or LARG and for the GTPase-activating protein activity of these proteins.	Lysine	14-20	Rho guanine nucleotide exchange factor 12	Homo sapiens	97-101
19854139-0	2009	Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.	Lysine	21-27	interferon regulatory factor 3	Homo sapiens	73-77
23891857-6	2013	When Lys(191) is deleted from hGnRHR and co-expressed with calnexin, IP production is similar to the rat sequence.	Lysine	5-8	gonadotropin releasing hormone receptor	Homo sapiens	30-36
23891857-7	2013	When rat GnRHR containing Lys(191) and the human motif is co-expressed with calnexin, IP production is similar to cells expressing the hGnRHR.	Lysine	26-29	gonadotropin releasing hormone receptor	Rattus norvegicus	9-14
15350139-9	2004	In BIAcore analysis, IGFBP-2 and IGFBP-3 bound only to the N(epsilon)(Lys65/68b)-IGF-1-coated flowcell of a biosensor chip, confirming the inaccessibility of Gly 1 and Lys 27 when IGF-1 is bound to IGFBP-2 and IGFBP-3.	Lysine	70-73	insulin like growth factor binding protein 2	Homo sapiens	21-28
23934551-2	2013	Replacement of lysine by alanine in the catalytic subunit yields the inactive (K851A)JAK3 mutant that underlies severe combined immune deficiency.	Lysine	15-21	Janus kinase 3	Mus musculus	85-89
15229220-7	2004	This study reveals that Rta is sumoylated at the Lys-19, Lys-213, and Lys-517 residues and that SUMO-1 conjugation at the Lys-19 residue is crucial for enhancing the transactivation activity of Rta.	Lysine	49-52	RNA binding fox-1 homolog 2	Homo sapiens	24-27
19826488-5	2009	hARD1, which is known to have the activity of protein lysine epsilon-acetylation, bound to and acetylated MLCK activated by Ca(2+) signaling, and by so doing deactivated MLCK, which led to a reduction in the phosphorylation of MLC.	Lysine	54-60	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	0-5
19617307-2	2009	This study is the first report showing that selective TLR2 stimulation by its ligand Pam(3)-Cys-Ser-Lys-Lys-Lys-Lys-OH (Pam(3)CSK(4)) within the alveolar compartment promoted lung inflammation in mice and induced the migration of circulatory immune cells including mononuclear phagocytes into the inflamed alveolar space.	Lysine	100-103	toll-like receptor 2	Mus musculus	54-58
15229220-7	2004	This study reveals that Rta is sumoylated at the Lys-19, Lys-213, and Lys-517 residues and that SUMO-1 conjugation at the Lys-19 residue is crucial for enhancing the transactivation activity of Rta.	Lysine	57-60	RNA binding fox-1 homolog 2	Homo sapiens	24-27
24238610-6	2013	Further, we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1.	Lysine	90-93	ferric-chelate reductase	Solanum lycopersicum	159-165
15229220-7	2004	This study reveals that Rta is sumoylated at the Lys-19, Lys-213, and Lys-517 residues and that SUMO-1 conjugation at the Lys-19 residue is crucial for enhancing the transactivation activity of Rta.	Lysine	57-60	RNA binding fox-1 homolog 2	Homo sapiens	24-27
15229220-7	2004	This study reveals that Rta is sumoylated at the Lys-19, Lys-213, and Lys-517 residues and that SUMO-1 conjugation at the Lys-19 residue is crucial for enhancing the transactivation activity of Rta.	Lysine	57-60	RNA binding fox-1 homolog 2	Homo sapiens	24-27
19617307-2	2009	This study is the first report showing that selective TLR2 stimulation by its ligand Pam(3)-Cys-Ser-Lys-Lys-Lys-Lys-OH (Pam(3)CSK(4)) within the alveolar compartment promoted lung inflammation in mice and induced the migration of circulatory immune cells including mononuclear phagocytes into the inflamed alveolar space.	Lysine	104-107	toll-like receptor 2	Mus musculus	54-58
19617307-2	2009	This study is the first report showing that selective TLR2 stimulation by its ligand Pam(3)-Cys-Ser-Lys-Lys-Lys-Lys-OH (Pam(3)CSK(4)) within the alveolar compartment promoted lung inflammation in mice and induced the migration of circulatory immune cells including mononuclear phagocytes into the inflamed alveolar space.	Lysine	104-107	toll-like receptor 2	Mus musculus	54-58
24260437-5	2013	Our data further indicate that the propeptide sequence and the lysine residues K26 and K27 regulate the precursor pVII protein stability in a co-dependent manner.	Lysine	63-69	keratin 27	Homo sapiens	87-90
19809202-7	2009	We found that Gap1 was removed from the plasma membrane in the presence of ethanol in a Rsp5-dependent manner, and that the disappearance of Gap1 required Ubc4 and involved the lysine residues of ubiquitin.	Lysine	177-183	ubiquitin	Saccharomyces cerevisiae S288C	196-205
19809202-10	2009	In addition, it appears that the substrates of Rsp5 are appropriately poly-ubiquitinated via different lysine residues of ubiquitin under various growth conditions.	Lysine	103-109	ubiquitin	Saccharomyces cerevisiae S288C	75-84
15327942-6	2004	By Western blotting with specific anti-acetyl-lysine antibody we demonstrated that Acs undergoes autoacetylation, that CheY is acetylated to a small extent when isolated, and that the extent is elevated following in vitro acetylation.	Lysine	46-52	acyl-CoA synthetase short chain family member 2	Homo sapiens	83-86
24077602-8	2013	They also showed that SAFB1 interacts with EZH2, SUZ12 and EED, three core components of the Polycomb repressive complex 2 (PRC2), which catalyzes the gene repression histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	191-197	scaffold attachment factor B	Homo sapiens	22-27
15240822-8	2004	In an HDA1 deletion, many Tup1-repressed genes are hyperacetylated at lysine 18 of histone H3, yet are not derepressed, indicating deacetylation alone is not sufficient to repress most Tup1-controlled genes.	Lysine	70-76	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	26-30
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	66-69	death domain associated protein	Homo sapiens	53-57
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	66-69	death domain associated protein	Homo sapiens	121-125
24077602-8	2013	They also showed that SAFB1 interacts with EZH2, SUZ12 and EED, three core components of the Polycomb repressive complex 2 (PRC2), which catalyzes the gene repression histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	191-197	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	49-54
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	109-112	death domain associated protein	Homo sapiens	53-57
23603107-5	2013	This accurate mass XIC data methodology was effective at identifying nitrotyrosine, chlorotyrosine, and oxidative deamination of lysine, and for tyrosine oxidations highlighted more modified peptide species than precursor ion scanning or statistical database searches.	Lysine	129-135	X chromosome inactivation center	Homo sapiens	19-22
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	109-112	death domain associated protein	Homo sapiens	121-125
19687346-5	2009	MG also reacts with lysine residues in proteins to generate advanced glycation end product, N(epsilon)-carboxy ethyl lysine, which also serves as a marker of MG. We hypothesized that markers of MG formation will be increased in the vasculature of preeclamptic women and that exogenous MG will induce oxidative stress by the upregulation of LOX-1 via arginase.	Lysine	20-26	oxidized low density lipoprotein receptor 1	Homo sapiens	340-345
15287725-1	2004	We have previously demonstrated that, in the presence of the lysine analogue epsilon-aminocaproic acid, apolipoprotein(a) [apo(a)] undergoes a conformational change from a closed to an open structure that is characterized by a change in tryptophan fluorescence, an increase in the radius of gyration, an alteration of domain stability, and an enhancement in the efficiency of covalent lipoprotein(a) [Lp(a)] formation.	Lysine	61-67	lipoprotein(a)	Homo sapiens	104-121
15287725-1	2004	We have previously demonstrated that, in the presence of the lysine analogue epsilon-aminocaproic acid, apolipoprotein(a) [apo(a)] undergoes a conformational change from a closed to an open structure that is characterized by a change in tryptophan fluorescence, an increase in the radius of gyration, an alteration of domain stability, and an enhancement in the efficiency of covalent lipoprotein(a) [Lp(a)] formation.	Lysine	61-67	lipoprotein(a)	Homo sapiens	123-129
15287725-1	2004	We have previously demonstrated that, in the presence of the lysine analogue epsilon-aminocaproic acid, apolipoprotein(a) [apo(a)] undergoes a conformational change from a closed to an open structure that is characterized by a change in tryptophan fluorescence, an increase in the radius of gyration, an alteration of domain stability, and an enhancement in the efficiency of covalent lipoprotein(a) [Lp(a)] formation.	Lysine	61-67	lipoprotein(a)	Homo sapiens	107-121
15287725-1	2004	We have previously demonstrated that, in the presence of the lysine analogue epsilon-aminocaproic acid, apolipoprotein(a) [apo(a)] undergoes a conformational change from a closed to an open structure that is characterized by a change in tryptophan fluorescence, an increase in the radius of gyration, an alteration of domain stability, and an enhancement in the efficiency of covalent lipoprotein(a) [Lp(a)] formation.	Lysine	61-67	lipoprotein(a)	Homo sapiens	401-406
15287725-4	2004	Using site-directed mutagenesis, we have identified the strong lysine-binding site present within apo(a) kringle IV type 10 as an important site within the C-terminal half of the molecule, which is involved in maintaining the closed conformation of apo(a).	Lysine	63-69	lipoprotein(a)	Homo sapiens	98-104
15287725-4	2004	Using site-directed mutagenesis, we have identified the strong lysine-binding site present within apo(a) kringle IV type 10 as an important site within the C-terminal half of the molecule, which is involved in maintaining the closed conformation of apo(a).	Lysine	63-69	lipoprotein(a)	Homo sapiens	249-255
15258597-5	2004	The amino-terminal domain of A20, which is a de-ubiquitinating (DUB) enzyme of the OTU (ovarian tumour) family, removes lysine-63 (K63)-linked ubiquitin chains from receptor interacting protein (RIP), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex.	Lysine	120-126	tumor necrosis factor, alpha-induced protein 3	Mus musculus	29-32
15280549-1	2004	An E2 ubiquitin-conjugating enzyme, Rad6, working with an E3 ubiquitin ligase Bre1, catalyzes monoubiquitylation of histone H2B on a C-terminal lysine residue.	Lysine	144-150	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	78-82
18498385-0	2009	Detection of Hb E mutation (beta26, GAG--&gt;AAG, Glu--&gt;Lys) using reverse dot-blot hybridization.	Lysine	59-62	hemoglobin subunit epsilon 1	Homo sapiens	13-17
23990460-9	2013	This ultimately prevented histone 3 lysine 9 trimethylation (H3K9me3) of the locus and enabled Hoxa9 expression.	Lysine	36-42	homeobox A9	Homo sapiens	95-100
15269344-6	2004	We show that the recruitment of G9a to the human p21(waf1/cdi1) promoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter.	Lysine	202-205	cut like homeobox 1	Homo sapiens	124-131
15269344-6	2004	We show that the recruitment of G9a to the human p21(waf1/cdi1) promoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter.	Lysine	202-205	cut like homeobox 1	Homo sapiens	124-131
24130751-7	2013	GCN2 and nutrition-dependent programming of Ppargamma2 is correlated with trimethylation of lysine 4 of histone 3 (H3K4me3) in the Ppargamma2 promoter region during neonatal development.	Lysine	92-98	peroxisome proliferator activated receptor gamma	Mus musculus	44-54
15070828-8	2004	Bovine TKDP-2 had a P1 lysine and the three conserved disulfides, but it possessed an unusual residue (Asp) at P2.	Lysine	23-29	trophoblast Kunitz domain protein 2	Bos taurus	7-13
20137623-10	2009	Bioinformatics analysis found that C5orf21 gene was located in chromosome 5q15 and C5orf21 protein contained Arb2 domain associated with histone H3 lysine 9 methylation.	Lysine	148-154	family with sequence similarity 172 member A	Homo sapiens	35-42
20137623-10	2009	Bioinformatics analysis found that C5orf21 gene was located in chromosome 5q15 and C5orf21 protein contained Arb2 domain associated with histone H3 lysine 9 methylation.	Lysine	148-154	family with sequence similarity 172 member A	Homo sapiens	83-90
24130751-7	2013	GCN2 and nutrition-dependent programming of Ppargamma2 is correlated with trimethylation of lysine 4 of histone 3 (H3K4me3) in the Ppargamma2 promoter region during neonatal development.	Lysine	92-98	peroxisome proliferator activated receptor gamma	Mus musculus	131-141
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	93-100	hemolysin transport protein	Escherichia coli	0-4
23926351-2	2013	Its predicted amino acid sequence is highly homologous to that of host insect histone H4 except for an extended N-terminal tail containing 38 amino acids with nine lysine residues.	Lysine	164-170	histone H4	Tribolium castaneum	78-88
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	93-100	hemolysin transport protein	Escherichia coli	39-43
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	101-104	hemolysin transport protein	Escherichia coli	0-4
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	101-104	hemolysin transport protein	Escherichia coli	39-43
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	113-116	hemolysin transport protein	Escherichia coli	0-4
19596862-2	2009	HlyA is synthesized as a protoxin, pro-HlyA, which is activated by acylation at two internal lysines Lys-563 and Lys-689.	Lysine	113-116	hemolysin transport protein	Escherichia coli	39-43
15481886-0	2004	The "hot-spot" of Hb E [beta26(B8)Glu--&gt;Lys] in Southeast Asia: beta-globin anomalies in the Lao Theung population of southern Laos.	Lysine	43-46	hemoglobin subunit epsilon 1	Homo sapiens	18-22
15481886-1	2004	Hb E [beta26(B8)Glu--&gt;Lys], is the most common abnormal hemoglobin (Hb) in Southeast Asian populations.	Lysine	25-28	hemoglobin subunit epsilon 1	Homo sapiens	0-4
23760740-5	2013	The approximate binding epitope was demonstrated from results on BABP samples in which different positively charged lysine residues were mutated to neutral alanines.	Lysine	116-122	aldo-keto reductase family 1 member C2	Homo sapiens	65-69
15161923-5	2004	Wild-type ADAMTS4 was co-localized with fibronectin as determined by confocal microscopy on the cell surface of stable 293T transfectants expressing ADAMTS4, although ADAMTS4 deletion mutants, including Delta Sp (Delta Arg(693)-Lys(837), lacking the spacer domain), showed negligible localization.	Lysine	228-231	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	10-17
19644017-1	2009	WNK1 [with-no-lysine (K)-1] is a ubiquitous serine/threonine kinase with a unique placement of the catalytic lysine residue.	Lysine	14-20	WNK lysine deficient protein kinase 1	Mus musculus	0-4
19644017-1	2009	WNK1 [with-no-lysine (K)-1] is a ubiquitous serine/threonine kinase with a unique placement of the catalytic lysine residue.	Lysine	109-115	WNK lysine deficient protein kinase 1	Mus musculus	0-4
23947381-8	2013	MEASUREMENTS AND MAIN RESULTS: Poly-L-lysine compacts CF sputum DNA, generating a liquid phase that improves ciliary beating frequency at the lung epithelial surface, and allows the control of neutrophil elastase and cathepsin G by their natural inhibitors.	Lysine	31-44	elastase, neutrophil expressed	Homo sapiens	193-212
19552406-14	2009	CONCLUSION: Favorable melanoma targeting property of (99m)Tc-RGD-Lys-(Arg(11))CCMSH and remarkable cytotoxic effect of RGD-Lys-(Arg(11))CCMSH in B16/F1 cells warranted the further evaluation of (188)Re-labeled alpha-MSH hybrid peptides as novel therapeutic peptides for melanoma treatment once the strategies of amino acid coinjection or structural modification of peptide sequence substantially reduce the renal uptake.	Lysine	123-126	pro-opiomelanocortin-alpha	Mus musculus	210-219
19627092-9	2009	Through the sequential coupling of a "product-selective" with a "substrate-selective" assay it was furthermore possible to monitor a multistep biochemical pathway, namely the decarboxylation of lysine to cadaverine by lysine decarboxylase followed by the oxidation of cadaverine by diamine oxidase.	Lysine	194-200	amine oxidase copper containing 1	Homo sapiens	282-297
15236911-1	2004	The single nucleotide polymorphism (SNP) of aldehyde dehydrogenase-2 (ALDH2) codon 487, GAA (Glu) or AAA (Lys), was examined using green fluorescent protein (GFP)-display, an electrophoretic detection method for single amino acid changes.	Lysine	106-109	aldehyde dehydrogenase 2 family member	Homo sapiens	44-68
15236911-1	2004	The single nucleotide polymorphism (SNP) of aldehyde dehydrogenase-2 (ALDH2) codon 487, GAA (Glu) or AAA (Lys), was examined using green fluorescent protein (GFP)-display, an electrophoretic detection method for single amino acid changes.	Lysine	106-109	aldehyde dehydrogenase 2 family member	Homo sapiens	70-75
15148321-5	2004	Here, we have identified four basic amino acid residues (Lys-312, Lys-316, Lys-401, and Arg-409) in the basic surface of the Smad7 MH2 domain that play important roles in interaction with type I receptors.	Lysine	57-60	SMAD family member 7 L homeolog	Xenopus laevis	125-130
15148321-5	2004	Here, we have identified four basic amino acid residues (Lys-312, Lys-316, Lys-401, and Arg-409) in the basic surface of the Smad7 MH2 domain that play important roles in interaction with type I receptors.	Lysine	66-69	SMAD family member 7 L homeolog	Xenopus laevis	125-130
23884422-6	2013	Moreover, we demonstrate that there are three critical residues (Arg-130, Lys-170, and Lys-411) necessary for IPK1 activity.	Lysine	74-77	inositol-pentakisphosphate 2-kinase	Homo sapiens	110-114
15148321-5	2004	Here, we have identified four basic amino acid residues (Lys-312, Lys-316, Lys-401, and Arg-409) in the basic surface of the Smad7 MH2 domain that play important roles in interaction with type I receptors.	Lysine	66-69	SMAD family member 7 L homeolog	Xenopus laevis	125-130
23884422-6	2013	Moreover, we demonstrate that there are three critical residues (Arg-130, Lys-170, and Lys-411) necessary for IPK1 activity.	Lysine	87-90	inositol-pentakisphosphate 2-kinase	Homo sapiens	110-114
15209504-6	2004	Furthermore, we observe specific contacts between lysine residues of apoC-II and protons near the phosphate group of DPC, consistent with the predictions of the so-called "snorkel hypothesis" of the structural basis for the apolipoprotein/lipid interaction (Segrest, J. P., Jackson, R. L., Morrisett, J. D., and Gotto, A. M., Jr. (1974) A molecular theory of lipid-protein interactions in the plasma lipoproteins, FEBS Lett 38, 247-258.).	Lysine	50-56	apolipoprotein C2	Homo sapiens	69-76
19625767-0	2009	Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.	Lysine	59-65	sirtuin 6	Homo sapiens	79-84
23818080-7	2013	The analysis of tryptic fragments from mono- and diPEGylated amylin revealed that conjugation occurred within the 1-11 amino acid region, most likely at the two amine groups of Lys(1).	Lysine	177-180	islet amyloid polypeptide	Homo sapiens	61-67
19577933-8	2009	The results indicate that specific interactions feasible for Arg/Lys and Trp in common must be there for aromatic residues in ORL1, thus forming a cation/pi interaction or pi/pi hydrophobic interaction.	Lysine	65-68	opioid related nociceptin receptor 1	Homo sapiens	126-130
15247330-6	2004	We also found that NDN lies in a domain of paternal allele-specific histone hyperacetylation that correlates with transcriptional state, and a domain of differential histone H3 lysine 4 di- and tri-methylation that persists independent of transcription.	Lysine	177-183	necdin, MAGE family member	Homo sapiens	19-22
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	127-130	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	127-130	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	127-130	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
15152190-4	2004	SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310.	Lysine	122-128	RELA proto-oncogene, NF-kB subunit	Homo sapiens	36-40
19609280-1	2009	WNK lysine-deficient protein kinase 1 (WNK1) is a member of the WNK family of serine/threonine kinases with no lysine (K), and these kinases have been implicated as important modulators of salt homeostasis in the kidney.	Lysine	4-10	WNK lysine deficient protein kinase 1	Homo sapiens	39-43
23872270-8	2013	In contrast, PSII yield was almost fully resistant to antimycin A in leaves accumulating endogenous levels of PtPGR5 or AtPGR5 V3K that had lysine instead of valine at the third position.	Lysine	140-146	proton gradient regulation 5	Arabidopsis thaliana	120-126
15152190-4	2004	SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310.	Lysine	122-128	RELA proto-oncogene, NF-kB subunit	Homo sapiens	110-114
15152190-4	2004	SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310.	Lysine	122-128	RELA proto-oncogene, NF-kB subunit	Homo sapiens	41-44
19436261-6	2009	Chromatin immunoprecipitation assays revealed that GCN5 targets to a subset of MIRNA genes and is required for acetylation of histone H3 lysine 14 at these loci.	Lysine	137-143	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	51-55
15107469-2	2004	Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corresponding lysine residues from Cx43 eliminated the block by 2 mm spermine, reduced the transjunctional voltage (V(j)) gating sensitivity, and reduced the unitary conductance of this Cx40E9,13K gap junction channel protein.	Lysine	132-138	gap junction protein, alpha 5	Mus musculus	104-108
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	109-112	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Lysine	109-112	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
19494038-5	2009	More than 100 differentially methylated regions (DMRs) were identified that are present mainly in cell type-specific genes (e.g., FOXP3, IL2RA, CTLA4, CD40LG, and IFNG) and show differential patterns of histone H3 lysine 4 methylation.	Lysine	214-220	forkhead box P3	Homo sapiens	130-135
23862699-2	2013	As these deficiencies coincide with aberrant levels of histone acetylation, we hypothesized that the key difference between p300 and CBP activity is differences in their specificity/selectivity for lysines within the histones.	Lysine	198-205	E1A binding protein p300	Homo sapiens	124-128
19494038-5	2009	More than 100 differentially methylated regions (DMRs) were identified that are present mainly in cell type-specific genes (e.g., FOXP3, IL2RA, CTLA4, CD40LG, and IFNG) and show differential patterns of histone H3 lysine 4 methylation.	Lysine	214-220	interleukin 2 receptor subunit alpha	Homo sapiens	137-142
18547756-9	2009	Furthermore, as lysine intake increased, the secretions of insulin, FSH, and LH were increased (P&lt;0.05) and multiparous sows showed higher (P&lt;0.05) concentrations of FSH and LH pulses on the day of postfarrowing and weaning, respectively.	Lysine	16-22	insulin	Sus scrofa	59-66
19289100-7	2009	Finally, a chromatin immunoprecipitation assay revealed reduced levels of histone H3 lysine 9 (H3K9) acetylation and H3K4 trimethylation with concomitant enhancement of H3K9 trimethylation in HBMEC relative to HBMP, which suggests that histone modifications are involved in the cell-specific expression of SDF-1.	Lysine	85-91	C-X-C motif chemokine ligand 12	Homo sapiens	306-311
19454348-1	2009	The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity.	Lysine	37-43	tripartite motif containing 25	Homo sapiens	21-27
19407372-2	2009	E2-25K is a dual-domain protein with an ubiquitin-associated (UBA) domain as well as a conserved ubiquitin-conjugating (UBC) domain which catalyzes the formation of a covalent bond between the C-terminal glycine of an ubiquitin molecule and the -amine of a lysine residue on the acceptor protein as part of the ubiquitin-proteasome pathway.	Lysine	257-263	ubiquitin C	Homo sapiens	120-123
19270100-8	2009	Our results indicated that lysine residues at positions 420 and 427 of enolase were crucial in plasminogen-binding activity.	Lysine	27-33	HMPREF1171_RS22025	Aeromonas hydrophila SSU	71-78
19304754-4	2009	MAML1 interacts with the C/H3 domain of p300, and the p300-MAML1 complex specifically acetylates lysines of histone H3 and H4 tails in chromatin in vitro.	Lysine	97-104	E1A binding protein p300	Homo sapiens	40-44
19304754-4	2009	MAML1 interacts with the C/H3 domain of p300, and the p300-MAML1 complex specifically acetylates lysines of histone H3 and H4 tails in chromatin in vitro.	Lysine	97-104	E1A binding protein p300	Homo sapiens	54-58
19251700-3	2009	Here, we report that AhRR has three evolutionarily conserved SUMOylation consensus sequences within its C-terminal repression domain and that Lys-542, Lys-583, and Lys-660 at the SUMOylation sites are modified by SUMO-1 in vivo.	Lysine	142-145	aryl hydrocarbon receptor repressor	Homo sapiens	21-25
19251700-3	2009	Here, we report that AhRR has three evolutionarily conserved SUMOylation consensus sequences within its C-terminal repression domain and that Lys-542, Lys-583, and Lys-660 at the SUMOylation sites are modified by SUMO-1 in vivo.	Lysine	142-145	small ubiquitin like modifier 1	Homo sapiens	213-219
19251700-3	2009	Here, we report that AhRR has three evolutionarily conserved SUMOylation consensus sequences within its C-terminal repression domain and that Lys-542, Lys-583, and Lys-660 at the SUMOylation sites are modified by SUMO-1 in vivo.	Lysine	151-154	aryl hydrocarbon receptor repressor	Homo sapiens	21-25
19251700-3	2009	Here, we report that AhRR has three evolutionarily conserved SUMOylation consensus sequences within its C-terminal repression domain and that Lys-542, Lys-583, and Lys-660 at the SUMOylation sites are modified by SUMO-1 in vivo.	Lysine	151-154	aryl hydrocarbon receptor repressor	Homo sapiens	21-25
19251700-5	2009	SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR.	Lysine	25-31	aryl hydrocarbon receptor repressor	Homo sapiens	82-86
19251700-5	2009	SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR.	Lysine	25-31	ankyrin repeat family A member 2	Homo sapiens	91-97
19251700-5	2009	SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR.	Lysine	25-31	aryl hydrocarbon receptor repressor	Homo sapiens	154-158
19393081-4	2009	RESULTS: In this study we identified ALIX as a POSH ubiquitination substrate in human cells: POSH induces the ubiquitination of ALIX that is modified on several lysine residues in vivo and in vitro.	Lysine	161-167	SH3 domain containing ring finger 1	Homo sapiens	47-51
19393081-4	2009	RESULTS: In this study we identified ALIX as a POSH ubiquitination substrate in human cells: POSH induces the ubiquitination of ALIX that is modified on several lysine residues in vivo and in vitro.	Lysine	161-167	SH3 domain containing ring finger 1	Homo sapiens	93-97
19208625-4	2009	Our data suggest that 1) Ub-Pex5p is deubiquitinated by a combination of context-dependent enzymatic and nonenzymatic mechanisms; 2) soluble Ub-Pex5p retains the capacity to interact with the peroxisomal import machinery in a cargo-dependent manner; and 3) substitution of the conserved cysteine residue of Pex5p by a lysine results in a quite functional protein both in vitro and in vivo.	Lysine	318-324	peroxisomal biogenesis factor 5	Homo sapiens	28-33
19208625-4	2009	Our data suggest that 1) Ub-Pex5p is deubiquitinated by a combination of context-dependent enzymatic and nonenzymatic mechanisms; 2) soluble Ub-Pex5p retains the capacity to interact with the peroxisomal import machinery in a cargo-dependent manner; and 3) substitution of the conserved cysteine residue of Pex5p by a lysine results in a quite functional protein both in vitro and in vivo.	Lysine	318-324	peroxisomal biogenesis factor 5	Homo sapiens	144-149
19208625-4	2009	Our data suggest that 1) Ub-Pex5p is deubiquitinated by a combination of context-dependent enzymatic and nonenzymatic mechanisms; 2) soluble Ub-Pex5p retains the capacity to interact with the peroxisomal import machinery in a cargo-dependent manner; and 3) substitution of the conserved cysteine residue of Pex5p by a lysine results in a quite functional protein both in vitro and in vivo.	Lysine	318-324	peroxisomal biogenesis factor 5	Homo sapiens	144-149
19233846-5	2009	Moreover, at the promoter of the gene for p16(Ink4a) in Jdp2(-/-) MEF, the extent of methylation of lysine 27 of histone H3 (H3K27), which is important for gene silencing, increased.	Lysine	100-106	E74-like factor 4 (ets domain transcription factor)	Mus musculus	56-69
19374733-10	2009	Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA.	Lysine	81-84	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	206-209
19230796-3	2009	A less well-known aspect of Rad6-mediated DNA repair, however, involves its function with Bre1 in mono-ubiquitinating the histone H2B residue lysine 123.	Lysine	142-148	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	90-94
19041871-5	2009	Mutation of specific lysine residues corresponding to residues at the dimer interface in human UROD enhanced the catalytic efficiency of the enzyme and dimer stability indicating that the lysine rich nature and weak dimer interface of the wild-type PfUROD could be responsible for its low catalytic efficiency.	Lysine	21-27	uroporphyrinogen decarboxylase	Homo sapiens	95-99
19041871-5	2009	Mutation of specific lysine residues corresponding to residues at the dimer interface in human UROD enhanced the catalytic efficiency of the enzyme and dimer stability indicating that the lysine rich nature and weak dimer interface of the wild-type PfUROD could be responsible for its low catalytic efficiency.	Lysine	188-194	uroporphyrinogen decarboxylase	Homo sapiens	95-99
18704955-3	2009	The site-specific (Lys(34)) PEGylated GLP-1s were synthesized with PEGs of 2, 5, and 10 kDa, respectively.	Lysine	19-22	glucagon	Mus musculus	38-43
18704955-6	2009	Particularly, Lys(34)-PEG(10K)-GLP-1 showed an stable hypoglycemic efficacy when administered up to 360 min preglucose.	Lysine	14-17	glucagon	Mus musculus	31-36
18704955-10	2009	Our findings suggest that GLP-1 substituted with a PEG of an appropriate Mw at Lys(34) could be used as a promising type 2 anti-diabetic agent to timely control postprandial glucose levels.	Lysine	79-82	glucagon	Mus musculus	26-31
19184981-1	2009	The ING2 plant homeodomain (PHD) finger is recruited to the nucleosome through specific binding to histone H3 trimethylated at lysine 4 (H3K4me3).	Lysine	127-133	inhibitor of growth family member 2	Homo sapiens	4-8
19351588-0	2009	Multiple lysine methylation of PCAF by Set9 methyltransferase.	Lysine	9-15	lysine acetyltransferase 2B	Homo sapiens	31-35
19351588-6	2009	Further methyltransferase assays focusing on the six lysine residues showed that K78 and K89 are preferentially methylated in full-length PCAF in vitro.	Lysine	53-59	lysine acetyltransferase 2B	Homo sapiens	138-142
20641511-12	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (12).	Lysine	56-59	alanyl aminopeptidase, membrane	Homo sapiens	118-121
20641652-12	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (12).	Lysine	56-59	alanyl aminopeptidase, membrane	Homo sapiens	118-121
19074424-0	2009	The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.	Lysine	35-41	carboxypeptidase B2	Homo sapiens	54-58
19074424-6	2009	When the three consecutive lysine residues in the activation peptide of TAFI were substituted with alanine (K42/43/44A), the catalytic efficiencies for TAFI activation with TM decreased 8-fold.	Lysine	27-33	carboxypeptidase B2	Homo sapiens	72-76
19074424-6	2009	When the three consecutive lysine residues in the activation peptide of TAFI were substituted with alanine (K42/43/44A), the catalytic efficiencies for TAFI activation with TM decreased 8-fold.	Lysine	27-33	carboxypeptidase B2	Homo sapiens	152-156
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Lysine	56-59	carboxypeptidase B2	Homo sapiens	50-54
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Lysine	65-68	carboxypeptidase B2	Homo sapiens	50-54
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Lysine	65-68	carboxypeptidase B2	Homo sapiens	50-54
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Lysine	65-68	carboxypeptidase B2	Homo sapiens	50-54
18821851-5	2009	Using additional r-apo(a) variants corresponding to deletions and/or site-directed mutants of various kringle domains in the molecule, we were able to determine that the observed effects of full-length r-apo(a) on HUVECs were dependent on the presence of a functional lysine-binding site(s) in the apo(a) molecule.	Lysine	268-274	lipoprotein(a)	Homo sapiens	204-210
18821851-5	2009	Using additional r-apo(a) variants corresponding to deletions and/or site-directed mutants of various kringle domains in the molecule, we were able to determine that the observed effects of full-length r-apo(a) on HUVECs were dependent on the presence of a functional lysine-binding site(s) in the apo(a) molecule.	Lysine	268-274	lipoprotein(a)	Homo sapiens	204-210
19305155-12	2009	Taken together these results demonstrate a role for H2AX Serine 139 phosphorylation in cell cycle regulation and apoptosis, and for Lysine 119 in the control of H2AX turnover.	Lysine	132-138	H2A.X variant histone	Homo sapiens	161-165
19070897-2	2009	Experiments with isolated membrane preparations showed that glycation of a lysine residue near the catalytic site of the pump ATPase had a powerful inhibitory effect.	Lysine	75-81	dynein axonemal heavy chain 8	Homo sapiens	126-132
19103210-5	2009	Further, spinal anti-NGF (3 microg) was able to reduce morphine analgesia in LPS-treated rats, but not in naive animals, an effect that was reversed by spinal administration of LY-225910.	Lysine	177-179	nerve growth factor	Rattus norvegicus	21-24
19166815-2	2009	We created mutants at the target sites (lysines 2 and 81) in the tailless HMGB1 modified by the histone acetyltransferase CBP.	Lysine	40-47	high mobility group box 1	Homo sapiens	74-79
19166815-7	2009	In the case of HMGB1DeltaC modified at Lys 2 and Lys 81 prior to PKC treatment background phosphorylation is detected.	Lysine	39-42	high mobility group box 1	Homo sapiens	15-20
19166815-7	2009	In the case of HMGB1DeltaC modified at Lys 2 and Lys 81 prior to PKC treatment background phosphorylation is detected.	Lysine	49-52	high mobility group box 1	Homo sapiens	15-20
19098288-7	2009	Consistent with this, we observed for the first time in a mammalian system that USP5 makes a major contribution to Lys-48-linked polyubiquitin disassembly and that suppression of USP5 results in the accumulation of unanchored polyubiquitin chains.	Lysine	115-118	ubiquitin specific peptidase 5	Homo sapiens	80-84
19098288-7	2009	Consistent with this, we observed for the first time in a mammalian system that USP5 makes a major contribution to Lys-48-linked polyubiquitin disassembly and that suppression of USP5 results in the accumulation of unanchored polyubiquitin chains.	Lysine	115-118	ubiquitin specific peptidase 5	Homo sapiens	179-183
19171762-5	2009	We report here that under normal conditions, Mult1 protein undergoes ubiquitination dependent on lysines in its cytoplasmic tail and lysosomal degradation.	Lysine	97-104	UL16 binding protein 1	Mus musculus	45-50
19203578-6	2009	RNF168 acts with UBC13 to amplify the RNF8-dependent histone ubiquitylation by targeting H2A-type histones and by promoting the formation of lysine 63-linked ubiquitin conjugates.	Lysine	141-147	ring finger protein 168	Homo sapiens	0-6
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	ring finger protein 168	Homo sapiens	13-19
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	H2A clustered histone 18	Homo sapiens	49-52
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	H2A clustered histone 18	Homo sapiens	119-122
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	H2A.X variant histone	Homo sapiens	127-131
19068087-9	2009	Analysis of genotype combinations showed that "ever drinking" with both ADH1B His/His and ALDH2 Lys + was the most potent risk factor for PC relative to "never drinkers" with both ADH1B His/His and ALDH2 Glu/Glu [OR (95% CI); 4.09 (1.30-12.85)].	Lysine	96-101	aldehyde dehydrogenase 2 family member	Homo sapiens	90-95
19087962-3	2009	While simultaneous mutation of many lysines in the alpha-subunit of NAC (Egd2p) was required to abolish its ubiquitination, for the beta-subunit of NAC (Egd1p), mutation of K29 and K30 was sufficient.	Lysine	36-43	Egd2p	Saccharomyces cerevisiae S288C	73-78
19008334-7	2009	Overexpressed ZKSCAN4 was found to co-localize in granular nuclear structures with the activated glucocorticoid receptor and partially with chromatin regions characterized by histone H3 mono-methylated on lysine 4 (H3K4me1).	Lysine	205-211	zinc finger with KRAB and SCAN domains 4	Homo sapiens	14-21
19015268-4	2009	Intramolecular acetylation targets five lysines within the nuclear localization signal at the P/CAF C terminus.	Lysine	40-47	lysine acetyltransferase 2B	Homo sapiens	94-99
19019820-8	2009	Point mutations in residues Phe-6, Gln-10, and Lys-80 destabilize Shq1p in vivo and induce a temperature-sensitive phenotype with depletion of H/ACA small nucleolar RNAs and defects in rRNA processing.	Lysine	47-50	Hsp90 cochaperone SHQ1	Saccharomyces cerevisiae S288C	66-71
20157594-5	2009	In response to DSBs, SIRT6 associates dynamically with chromatin and is necessary for an acute decrease in global cellular acetylation levels on histone H3 Lysine 9.	Lysine	156-162	sirtuin 6	Homo sapiens	21-26
19135894-3	2009	Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits Smad4 by impeding association with phospho-Smad2.	Lysine	30-36	SMAD family member 4	Homo sapiens	0-5
19135894-3	2009	Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits Smad4 by impeding association with phospho-Smad2.	Lysine	30-36	SMAD family member 4	Homo sapiens	79-84
19135894-3	2009	Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits Smad4 by impeding association with phospho-Smad2.	Lysine	30-36	SMAD family member 2	Homo sapiens	122-127
19056850-7	2009	On the other hand, the methylation levels of lysine 20 (K20) on histone H4 showed a significant correlation with HP1gamma expression in both these preadipocyte cells and normal tissue samples.	Lysine	45-51	chromobox 3	Homo sapiens	113-121
19650971-3	2009	Plasmid DNA encoding for GDNF was compacted into DNA nanoparticles (DNPs) by 10 kDa polyethylene glycol (PEG)-substituted lysine 30-mers (CK(30)PEG10k) and then injected into the denervated striatum of rats with unilateral 6-hydroxydopamine lesions.	Lysine	122-128	glial cell derived neurotrophic factor	Rattus norvegicus	25-29
18781344-0	2009	Effect of metal binding and posttranslational lysine carboxylation on the activity of recombinant hydantoinase.	Lysine	46-52	AWN88_RS03840	Agrobacterium tumefaciens	98-110
18781344-1	2009	Bacterial hydantoinase possesses a binuclear metal center in which two metal ions are bridged by a posttranslationally carboxylated lysine.	Lysine	132-138	AWN88_RS03840	Agrobacterium tumefaciens	10-22
18781344-2	2009	How the carboxylated lysine and metal binding affect the activity of hydantoinase was investigated.	Lysine	21-27	AWN88_RS03840	Agrobacterium tumefaciens	69-81
18781344-7	2009	However, the activity of K148A could be chemically rescued by short-chain carboxylic acids in the presence of cobalt, indicating that the carboxylated lysine was needed to coordinate the binuclear ion within the active site of hydantoinase.	Lysine	151-157	AWN88_RS03840	Agrobacterium tumefaciens	227-239
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Lysine	194-197	GDNF family receptor alpha 1	Homo sapiens	137-148
18845535-10	2008	Interestingly, in our structure, sucrose octasulfate also binds to the Arg(190)-Lys(202) region in GFR alpha 1 domain 2.	Lysine	80-83	GDNF family receptor alpha 1	Homo sapiens	99-110
19022951-4	2008	Here, we demonstrate that the covalent binding of the vitamin biotin to lysine-12 in histone H4 (H4K12bio) and lysine-9 in histone H2A (H2AK9bio), mediated by holocarboxylase synthetase (HCS), is an epigenetic mechanism to repress retrotransposon transcription in human and mouse cell lines and in primary cells from a human supplementation study.	Lysine	72-78	holocarboxylase synthetase	Homo sapiens	159-185
19022951-4	2008	Here, we demonstrate that the covalent binding of the vitamin biotin to lysine-12 in histone H4 (H4K12bio) and lysine-9 in histone H2A (H2AK9bio), mediated by holocarboxylase synthetase (HCS), is an epigenetic mechanism to repress retrotransposon transcription in human and mouse cell lines and in primary cells from a human supplementation study.	Lysine	72-78	holocarboxylase synthetase	Homo sapiens	187-190
19067896-6	2008	The 9 bp deletion of three amino acids Lys-Glu-Lys (1378-1380), which was located in the nuclear localization domain of treacle, seemed not essential for the treacle function.	Lysine	39-42	treacle ribosome biogenesis factor 1	Homo sapiens	120-127
19067896-6	2008	The 9 bp deletion of three amino acids Lys-Glu-Lys (1378-1380), which was located in the nuclear localization domain of treacle, seemed not essential for the treacle function.	Lysine	47-50	treacle ribosome biogenesis factor 1	Homo sapiens	120-127
18694457-4	2008	Histone H3 lysine-27 di- and tri-methylation are paternally enriched at the imprinted loci Mez1, ZmFie1 and Nrp1.	Lysine	11-17	polycomb group protein FIE1	Zea mays	97-103
19026780-0	2008	EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.	Lysine	40-46	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	0-4
19090811-3	2008	ARD1 may also acetylate the internal lysine residues of proteins.	Lysine	37-43	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	0-4
18765661-4	2008	Whereas mutation of two critical lysine residues within the second Ras-association domain of PLC-epsilon prevented K-Ras-dependent activation of the purified enzyme, guanine nucleotide-dependent activation by RhoA was retained.	Lysine	33-39	phospholipase C like 1 (inactive)	Homo sapiens	93-104
15163799-7	2004	Replacements of lysine residues with arginine showed that Siah1A-mediated ubiquitination occurs at multiple lysine residues spanning both the seven-transmembrane region and carboxyl-terminal tail of mGluR5.	Lysine	16-22	siah E3 ubiquitin protein ligase 1	Homo sapiens	58-64
15163799-7	2004	Replacements of lysine residues with arginine showed that Siah1A-mediated ubiquitination occurs at multiple lysine residues spanning both the seven-transmembrane region and carboxyl-terminal tail of mGluR5.	Lysine	108-114	siah E3 ubiquitin protein ligase 1	Homo sapiens	58-64
15170505-3	2004	The resulting homopolymers are further stabilized when the plasma transglutaminase (TGase) intermolecularly cross-links epsilon-(gamma-glutamyl)lysine bonds.	Lysine	143-150	transglutaminase 1	Homo sapiens	66-82
15170505-3	2004	The resulting homopolymers are further stabilized when the plasma transglutaminase (TGase) intermolecularly cross-links epsilon-(gamma-glutamyl)lysine bonds.	Lysine	143-150	transglutaminase 1	Homo sapiens	84-89
15169878-6	2004	Chromatin immunoprecipitation assays showed that treatment of cells with TSA or silencing of HDAC3 expression by small interfering RNA causes the hyperacetylation of Lys-9 in histone H3 on the gdf11 promoter.	Lysine	166-169	histone deacetylase 3	Homo sapiens	93-98
15147196-6	2004	Site-specific mutagenic experiments on the lysine and tyrosine residues of LRAT reveal that only the highly conserved tyrosine 154 is essential for catalytic activity.	Lysine	43-49	lecithin retinol acyltransferase	Homo sapiens	75-79
15016834-1	2004	Previous studies on the membrane-cytoplasm interphase of human integrin subunits have shown that a conserved lysine in subunits alpha(2), alpha(5), beta(1), and beta(2) is embedded in the plasma membrane in the absence of interacting proteins (Armulik, A., Nilsson, I., von Heijne, G., and Johansson, S. (1999) in J. Biol.	Lysine	109-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	161-168
15132742-9	2004	This function, which requires the integrity of the conserved lysine, both allows for activation at AP-1 with anti-estrogens (with ERbeta and ERalpha DBD-LBD), and prevents ERalpha from becoming superactive at AP-1 with estrogens.	Lysine	61-67	estrogen receptor 2	Homo sapiens	130-136
14752096-0	2004	AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.	Lysine	77-83	E1A binding protein p300	Homo sapiens	39-43
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	75-81	E1A binding protein p300	Homo sapiens	33-37
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	92-95	E1A binding protein p300	Homo sapiens	33-37
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	103-106	E1A binding protein p300	Homo sapiens	33-37
15095009-5	2004	The effects of plasmin are specific, require the active catalytic center and can be antagonized by lysine analogues, implying binding of the plasmin molecule to the cell membrane through its lysine binding sites.	Lysine	99-105	plasminogen	Homo sapiens	15-22
15095009-5	2004	The effects of plasmin are specific, require the active catalytic center and can be antagonized by lysine analogues, implying binding of the plasmin molecule to the cell membrane through its lysine binding sites.	Lysine	99-105	plasminogen	Homo sapiens	141-148
15095009-5	2004	The effects of plasmin are specific, require the active catalytic center and can be antagonized by lysine analogues, implying binding of the plasmin molecule to the cell membrane through its lysine binding sites.	Lysine	191-197	plasminogen	Homo sapiens	15-22
15095009-5	2004	The effects of plasmin are specific, require the active catalytic center and can be antagonized by lysine analogues, implying binding of the plasmin molecule to the cell membrane through its lysine binding sites.	Lysine	191-197	plasminogen	Homo sapiens	141-148
15031712-2	2004	The trxG proteins Ash1 and hTRX and the PcG repressor E(z) are histone methyltransferases (HMTases) that methylate distinct lysine residues in the N-terminal tail of histone H3.	Lysine	124-130	ASH1 like histone lysine methyltransferase	Homo sapiens	18-22
15035638-6	2004	Moreover, electrostatic and hydrogen-bonding interactions occur between the terminal lysine residues of L(24) and L(24)DAP and the polar headgroups of PG bilayers.	Lysine	85-91	death associated protein	Homo sapiens	119-122
14665632-5	2004	Although the p33ING1-Sin3-HDAC and DMAP1-DNMT1 complexes are recruited independently to pericentric heterochromatin regions, they are both required for deacetylation of histones and methylation of histone H3 at lysine 9.	Lysine	211-217	DNA methyltransferase 1 associated protein 1	Homo sapiens	35-40
15832508-5	2004	For all nucleoside parent drugs, BPHL preferred the hydrophobic amino acids valine, phenylalanine, and proline over the charged amino acids lysine and aspartic acid.	Lysine	140-146	biphenyl hydrolase like	Homo sapiens	33-37
15031665-6	2004	The association of pVHL and HIF-1alpha under normoxic conditions is triggered by the hydroxylation of prolines and the acetylation of lysine within a polypeptide segment known as the oxygen-dependent degradation (ODD) domain.	Lysine	134-140	von Hippel-Lindau tumor suppressor	Homo sapiens	19-23
14967049-9	2004	Phosphorylation in bovine NFM occurs mainly in the Lys-Ser-Pro (KSP) region, but the Val-Ser-Pro and Ser-Glu-Lys motifs are also phosphorylated.	Lysine	51-54	neurofilament medium chain	Bos taurus	26-29
14756555-7	2004	The structure also confirms the prediction from sequence alignment that Lys-227 is the PLP-binding residue in P. fluorescens kynureninase.	Lysine	72-75	pyridoxal phosphatase	Homo sapiens	87-90
14711989-5	2004	We also show that lysine 16 of histone H4 becomes deacetylated in the proximity of a chromosomal DNA double-strand break in a Sin3p-dependent manner.	Lysine	18-24	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	126-131
14732680-6	2004	MS and antibody characterization of separated histone 3 fractions revealed that H3.3 is relatively enriched in modifications associated with transcriptional activity and deficient in dimethyl lysine-9, which is abundant in heterochromatin.	Lysine	192-198	Histone H3.3A	Drosophila melanogaster	80-84
14581473-0	2004	Quantitative evaluation of the contribution of weak lysine-binding sites present within apolipoprotein(a) kringle IV types 6-8 to lipoprotein(a) assembly.	Lysine	52-58	lipoprotein(a)	Homo sapiens	88-105
14581473-9	2004	Taken together, our data demonstrate that specific interactions between apo(a) KIV(7) and KIV(8) and Lys(680) and Lys(690) in apoB mediate a high affinity non-covalent interaction between apo(a) and low density lipoprotein, which dictates the efficiency of covalent Lp(a) formation.	Lysine	101-104	lipoprotein(a)	Homo sapiens	266-271
14737116-7	2004	Efficient growth arrest by p16/Rb is dependent on histone H3 lysine 9 methylation, which provides a binding site for HP1.	Lysine	61-67	RB transcriptional corepressor 1	Homo sapiens	31-33
14660634-2	2004	Given the requirement of Rad6/Bre1-dependent ubiquitination of histone H2B for H3 dimethylation (at lysines 4 and 79) and gene silencing (2-7), removal of ubiquitin from H2B may have a significant regulatory effect on transcription.	Lysine	100-107	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	30-34
15015228-2	2004	Activated TAFI (TAFIa) reduces a generation of plasmin because it cleaves off the carboxy-terminal lysine residues from partially degraded fibrin and thereby abrogates the fibrin cofactor function in the tPA-mediated catalysis of plasminogen to plasmin.	Lysine	99-105	plasminogen	Homo sapiens	47-54
14551188-1	2003	The lysyl oxidase-like protein 4 (LOXL4) is the latest member of the emerging family of lysyl oxidases, several of which were shown to function as copper-dependent amine oxidases catalyzing lysine-derived cross-links in extracellular matrix proteins.	Lysine	190-196	lysyl oxidase like 4	Homo sapiens	4-32
14551188-1	2003	The lysyl oxidase-like protein 4 (LOXL4) is the latest member of the emerging family of lysyl oxidases, several of which were shown to function as copper-dependent amine oxidases catalyzing lysine-derived cross-links in extracellular matrix proteins.	Lysine	190-196	lysyl oxidase like 4	Homo sapiens	34-39
14557258-1	2003	Lipoprotein(a), Lp(a), an athero-thrombotic risk factor, reacts with EO6, a natural monoclonal autoantibody that recognizes the phophorylcholine (PC) group of oxidized phosphatidylcholine (oxPtdPC) either as a lipid or linked by a Schiff base to lysine residues of peptides/proteins.	Lysine	246-252	lipoprotein(a)	Homo sapiens	16-21
14514699-3	2003	Sumoylation of Smad4 mainly occurs at lysine 159, located in the linker region, and facilitates Smad-dependent transcriptional activation.	Lysine	38-44	SMAD family member 4	Homo sapiens	15-20
14514699-3	2003	Sumoylation of Smad4 mainly occurs at lysine 159, located in the linker region, and facilitates Smad-dependent transcriptional activation.	Lysine	38-44	SMAD family member 4	Homo sapiens	15-19
14500712-8	2003	Sumoylation occurred on Lys-152, a residue conserved in FAK during evolution.	Lysine	24-27	protein tyrosine kinase 2	Homo sapiens	56-59
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	proteinase 3	Homo sapiens	5-8
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	Fc gamma receptor IIa	Homo sapiens	32-43
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
12920115-2	2003	These PB1 domains harbor either a conserved lysine residue on one side or an acidic OPCA (OPR/PC/AID) motif around the other side; the lysine of p67phox or Bem1p likely binds to the OPCA of p40phox or Cdc24p, respectively, via electrostatic interactions.	Lysine	135-141	Rho family guanine nucleotide exchange factor CDC24	Saccharomyces cerevisiae S288C	201-207
12853452-0	2003	Identification and characterization of novel lysine-independent apolipoprotein(a)-binding sites in fibrin(ogen) alphaC-domains.	Lysine	45-51	lipoprotein(a)	Homo sapiens	64-81
12853452-11	2003	These results indicate that the alphaC-domains contain novel high affinity apo(a)-binding sites that may provide a Lys-independent mechanism for bringing Lp(a) to places of fibrin deposition such as injured vessels or atherosclerotic lesions.	Lysine	115-118	lipoprotein(a)	Homo sapiens	154-159
12807997-10	2003	More particularly, three residues within the loop, i.e., Trp-7, Lys-8, and Tyr-9, are required for receptor recognition and activation.	Lysine	64-67	transient receptor potential cation channel subfamily C member 7	Homo sapiens	57-62
12917345-3	2003	Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116.	Lysine	28-34	E1A binding protein p300	Homo sapiens	8-12
12898623-1	2003	Proteolytic activation of the HIV-1 envelope glycoprotein gp160 is selectively performed by the proprotein convertase furin at the C-terminus of the sequence R508-E-K-R511 (site 1), in spite of the presence of another consensus sequence, Lys500-Ala-Lys-Arg503 (site 2).	Lysine	238-241	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	58-63
12898623-1	2003	Proteolytic activation of the HIV-1 envelope glycoprotein gp160 is selectively performed by the proprotein convertase furin at the C-terminus of the sequence R508-E-K-R511 (site 1), in spite of the presence of another consensus sequence, Lys500-Ala-Lys-Arg503 (site 2).	Lysine	238-241	furin, paired basic amino acid cleaving enzyme	Homo sapiens	118-123
12897052-0	2003	Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.	Lysine	91-94	Polycomb	Drosophila melanogaster	41-49
12897052-2	2003	Recent studies suggest that Polycomb mediates the assembly of repressive higher-order chromatin structures in conjunction with the methylation of Lys 27 of histone H3 by a Polycomb group repressor complex.	Lysine	146-149	Polycomb	Drosophila melanogaster	28-36
12897052-2	2003	Recent studies suggest that Polycomb mediates the assembly of repressive higher-order chromatin structures in conjunction with the methylation of Lys 27 of histone H3 by a Polycomb group repressor complex.	Lysine	146-149	Polycomb	Drosophila melanogaster	172-180
12897052-4	2003	To understand the molecular mechanism of the methyl-Lys 27 histone code recognition, we have determined a 1.4-A-resolution structure of the chromodomain of Polycomb in complex with a histone H3 peptide trimethylated at Lys 27.	Lysine	52-55	Polycomb	Drosophila melanogaster	156-164
12897052-4	2003	To understand the molecular mechanism of the methyl-Lys 27 histone code recognition, we have determined a 1.4-A-resolution structure of the chromodomain of Polycomb in complex with a histone H3 peptide trimethylated at Lys 27.	Lysine	219-222	Polycomb	Drosophila melanogaster	156-164
12897054-3	2003	In Drosophila S2 cells, and on polytene chromosomes, methyl-Lys 27 and Pc are both excluded from areas that are enriched in methyl-Lys 9 and HP1.	Lysine	131-134	Polycomb	Drosophila melanogaster	71-73
12811824-4	2003	The ASYIP protein contains two hydrophobic regions and a double lysine endoplasmic reticulum (ER) retrieval motif at its C-terminus, which was shown to be identical to RTN3, a reticulon family protein of unknown function.	Lysine	64-70	reticulon 3	Homo sapiens	4-9
12811824-4	2003	The ASYIP protein contains two hydrophobic regions and a double lysine endoplasmic reticulum (ER) retrieval motif at its C-terminus, which was shown to be identical to RTN3, a reticulon family protein of unknown function.	Lysine	64-70	reticulon 3	Homo sapiens	168-172
12867553-9	2003	Thirdly, as with many plasminogen receptors, binding of Candida enolase to plasmin(ogen) is lysine-dependent, whereas little inhibition occurred with arginine, aspartate and glutamate.	Lysine	92-98	plasminogen	Homo sapiens	22-29
12885887-11	2003	Using a transfection-based approach and a family of deletion and point mutations of PML, we found that efficient ICP0-induced PML degradation requires sequences within the C-terminal part of PML and lysine residue 160, one of the principal targets for SUMO-1 modification of the protein.	Lysine	199-205	small ubiquitin like modifier 1	Homo sapiens	252-258
12888487-6	2003	The intramolecular acetylation targets five lysines (416-442) at the P/CAF C-terminus, which are in the nuclear localisation signal (NLS).	Lysine	44-51	lysine acetyltransferase 2B	Homo sapiens	69-74
12740389-7	2003	A major sumoylation site in Smad4 was localized to Lys-159 in its linker segment with an additional site at Lys-113 in the MH-1 domain.	Lysine	51-54	SMAD family member 4	Homo sapiens	28-33
12740389-7	2003	A major sumoylation site in Smad4 was localized to Lys-159 in its linker segment with an additional site at Lys-113 in the MH-1 domain.	Lysine	108-111	SMAD family member 4	Homo sapiens	28-33
12740389-9	2003	Replacement of lysines 159 and 113 by arginines or increased sumoylation enhanced the stability of Smad4, and transcription in mammalian cells and Xenopus embryos.	Lysine	15-22	SMAD family member 4	Homo sapiens	99-104
12691605-9	2003	In conclusion, although the accepted furin processing motif is Arg-Xaa-(Lys/Arg)-Arg downward arrow, our data further extend it to include a regulatory histidine residue at P6 in precursors that lack a basic residue at P4.	Lysine	72-75	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
12734181-2	2003	The binding of CaM is mediated in part by the electrostatic interaction between residues Arg-464 and Lys-467 of SK2 and Glu-84 and Glu-87 of CaM.	Lysine	101-104	sphingosine kinase 2	Homo sapiens	112-115
12738767-2	2003	In this study we identified, by mass spectrometry, two lysine residues in the DNA binding domain (DBD), Lys-75 and Lys-78, to be the major acetylation sites in IRF-2.	Lysine	55-61	interferon regulatory factor 2	Mus musculus	160-165
12738767-2	2003	In this study we identified, by mass spectrometry, two lysine residues in the DNA binding domain (DBD), Lys-75 and Lys-78, to be the major acetylation sites in IRF-2.	Lysine	104-107	interferon regulatory factor 2	Mus musculus	160-165
12738767-2	2003	In this study we identified, by mass spectrometry, two lysine residues in the DNA binding domain (DBD), Lys-75 and Lys-78, to be the major acetylation sites in IRF-2.	Lysine	115-118	interferon regulatory factor 2	Mus musculus	160-165
12738767-3	2003	Although acetylation of IRF-2 did not alter DNA binding activity in vitro, mutation of Lys-75 diminished the IRF-2-dependent activation of histone H4 promoter activity.	Lysine	87-90	interferon regulatory factor 2	Mus musculus	109-114
12819663-6	2003	The avid binding of AID to ssDNA could result from its large net positive charge (+11) at pH 7.0, owing to a basic amino-terminal domain enriched in arginine and lysine.	Lysine	162-168	activation induced cytidine deaminase	Homo sapiens	20-23
12870893-6	2003	In the case of the more reactive ONE, the adducts detected were the ONE-His Michael adduct (on H24), the ONE-Lys pyrrolinone adduct (on K16 and K145), and the ONE-His-Lys pyrrole cross-link (linking K16 to H24 in the C(5) peptide).	Lysine	167-170	keratin 16	Homo sapiens	199-202
12828639-3	2003	The C-terminal lysyl residues of Eno at position 433 and 434 were identified as a binding site for the kringle motifs of plasmin(ogen) which contain lysine binding sites.	Lysine	149-155	plasminogen	Homo sapiens	121-128
12887910-3	2003	These genes are surrounded by Lys-9-methylated H3 histones, and their promoters are occupied by the pRb-related protein p130 and the inhibitory transcription factor E2F4.	Lysine	30-33	RB transcriptional corepressor 1	Homo sapiens	100-103
12887910-3	2003	These genes are surrounded by Lys-9-methylated H3 histones, and their promoters are occupied by the pRb-related protein p130 and the inhibitory transcription factor E2F4.	Lysine	30-33	E2F transcription factor 4	Homo sapiens	165-169
12887910-4	2003	Kinetic analysis indicates that E1A binds to E2F promoters where it eliminates p130 and E2F4, resulting in the dramatic elimination of H3 Lys-9 methylation.	Lysine	138-141	E2F transcription factor 4	Homo sapiens	88-92
12794637-3	2003	Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs.	Lysine	81-84	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12794637-5	2003	Contoured surface loops shape the active site by cleft, thus explaining furin"s stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets.	Lysine	133-139	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Lysine	120-126	plasminogen	Homo sapiens	31-38
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Lysine	120-126	carboxypeptidase B2	Homo sapiens	40-44
12866625-8	2003	It was estimated that approximately 20% of the available Lys residues in NaCN were involved in TGase-catalysed cross-links.	Lysine	57-60	transglutaminase 1	Homo sapiens	95-100
12549978-8	2003	Although a destabilization signal is mapped within the C-terminal 43-amino acid segment of SRp55, its adjacent lysine/serine-rich RS domain is nevertheless critical for the Clk/Sty-mediated degradation.	Lysine	111-117	serine and arginine rich splicing factor 6	Homo sapiens	91-96
12875689-1	2003	OBJECTIVE: To assess the atherogenicity of lipoprotein(a), the effect of the heterogeneity of lysine binding of apolipoprotein(a) [apo(a)], a plasminogen-like glycoprotein component on the proliferation of human arterial smooth muscle cells (SMCs).	Lysine	94-100	lipoprotein(a)	Homo sapiens	112-129
12694166-0	2003	Complex interaction of Hb Hekinan [alpha27(B8) Glu-Asp] and Hb E [beta26(B8) Glu-Lys] with a deletional alpha-thalassemia 1 in a Thai family.	Lysine	81-84	hemoglobin subunit epsilon 1	Homo sapiens	60-64
12694166-1	2003	Hemoglobin (Hb) Hekinan (alpha27; Glu-Asp) is a rare alpha-chain variant found mainly in Japanese and Chinese whereas Hb E (beta26; Glu-Lys) is common among Southeast Asians.	Lysine	136-139	hemoglobin subunit epsilon 1	Homo sapiens	118-122
12756539-8	2003	Substitution of threonine 416, glycine 418, serine 419, and lysine 424 of the adenylation domain (TXGSXXXXK, residues 416-424) resulted in a significant reduction in alpha-aminoadipate reductase activity compared to the unmutagenized Lys2p control.	Lysine	60-66	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	234-239
12753586-6	2003	The C-terminus of 14-3-3omega appears to undergo a conformational change in the presence of polycations as demonstrated by its increased trypsin cleavage at Lys-247.	Lysine	157-160	general regulatory factor 2	Arabidopsis thaliana	18-29
18619497-6	2008	We further demonstrated that the sumoylation of CEBPD lysine 120 is also detectable in HepG2 cells, and this modification functions for binding of the recruits, HDAC1 and HDAC3.	Lysine	54-60	histone deacetylase 3	Homo sapiens	171-176
18662993-3	2008	Polycomb repressive complex 2 is recruited through the interaction of CTCF with Suz12, leading to allele-specific methylation at lysine 27 of histone H3 (H3-K27) and to suppression of the maternal Igf2 promoters.	Lysine	129-135	CCCTC-binding factor	Mus musculus	70-74
18662993-3	2008	Polycomb repressive complex 2 is recruited through the interaction of CTCF with Suz12, leading to allele-specific methylation at lysine 27 of histone H3 (H3-K27) and to suppression of the maternal Igf2 promoters.	Lysine	129-135	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	80-85
18818304-7	2008	Mutation of Bax at K128, which corresponds to a conserved lysine in Kv1.3-inhibiting toxins, abrogated its effects on both Kv1.3 and mitochondria.	Lysine	58-64	potassium voltage-gated channel subfamily A member 3	Homo sapiens	68-73
18818304-7	2008	Mutation of Bax at K128, which corresponds to a conserved lysine in Kv1.3-inhibiting toxins, abrogated its effects on both Kv1.3 and mitochondria.	Lysine	58-64	potassium voltage-gated channel subfamily A member 3	Homo sapiens	123-128
18766256-3	2008	Following protein refolding and purification on lysine-Sepharose, the conversion of the recombinant molecule Delta(K2-K5)Pg to the active enzyme mutant Delta(K2-K5)Pm by plasminogen activators was evaluated, and functional characteristics of the simplified plasmin were studied.	Lysine	48-54	plasminogen	Homo sapiens	170-177
18583067-4	2008	Sequence analysis revealed that, like human LPTS/PinX1, the zLPTS protein has a conserved G-patch domain at its N-terminus and a lysine-rich domain at its C-terminus.	Lysine	129-135	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	49-54
18670082-3	2008	However, the mutation of negatively charged aspartic acid to positively charged lysine is still remained to be examined, which is very important to know for fully understanding the characteristics of beta(1)-AR.	Lysine	80-86	adrenoceptor beta 1	Homo sapiens	200-210
18670082-4	2008	At the present study, we mutated aspartic acid to lysine (Asp104Lys) residue in human beta(1)-AR.	Lysine	50-56	adrenoceptor beta 1	Homo sapiens	86-96
18670082-10	2008	Thus, we may suggest that mutation of negatively charged aspartic acid to positively charged lysine as well as neutral charged alanine may help to understand the mechanism of the activation or inactivation of beta(1)-AR by its conformational changes and this finding would be helpful for clarifying the functional responses mediated by beta(1)-AR.	Lysine	93-99	adrenoceptor beta 1	Homo sapiens	209-219
12566443-2	2003	In this study, we used analytical ultracentrifugation, differential scanning calorimetry, and intrinsic fluorescence to demonstrate that in the presence of the lysine analog epsilon-aminocaproic acid, apo(a) undergoes a substantial conformational change from a "closed" to an "open" structure that is characterized by an increase in the hydrodynamic radius (approximately 10%), an alteration in domain stability, as well as a decrease in tryptophan fluorescence.	Lysine	160-166	lipoprotein(a)	Homo sapiens	201-207
23862699-3	2013	Utilizing a label-free, quantitative mass spectrometry based technique, we determined the kinetic parameters of both CBP and p300 at each lysine of H3 and H4, under conditions we would expect to encounter in the cell (either limiting acetyl-CoA or histone).	Lysine	138-144	E1A binding protein p300	Homo sapiens	125-129
12562776-2	2003	Substitution of Arg(440) in IL5 with other residues except positively charged Lys caused a large shift in pH(i) dependence of (22)Na(+) uptake to an acidic side, whereas substitution of Gly(455) or Gly(456) within the highly conserved glycine-rich sequence of TM11 shifted pH(i) dependence to an alkaline side.	Lysine	78-81	interleukin 5	Homo sapiens	28-31
23862699-9	2013	This discovery of unique specificity for targets of CBP- vs p300-mediated acetylation of histone lysine residues presents a new model for understanding their respective biological roles and possibly an opportunity for selective therapeutic intervention.	Lysine	97-103	E1A binding protein p300	Homo sapiens	60-64
23750013-0	2013	The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3.	Lysine	108-114	survival of motor neuron 1, telomeric	Homo sapiens	41-44
12649488-2	2003	The Drosophila homolog of the Eed-Ezh2 PcG protein complex achieves gene silencing through methylation of histone H3 on lysine 27 (H3-K27), which suggests a role for H3-K27 methylation in imprinted X inactivation.	Lysine	120-126	Polycomb	Drosophila melanogaster	39-42
18499670-6	2008	The activity of FP6 also was blocked by mutating Lys(1370) and Lys(1374), which precludes LRP-1 binding.	Lysine	63-66	LDL receptor related protein 1	Rattus norvegicus	90-95
23750013-3	2013	SMN belongs to the Tudor domain protein family, whose members are known to interact with methylated arginine (R) or lysine (K) residues.	Lysine	116-122	survival of motor neuron 1, telomeric	Homo sapiens	0-3
23898190-4	2013	SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replication stress in a manner that is partially dependent on ataxia telangiectasia and Rad3 related (ATR) but not cyclin T or K, thereby stimulating CDK9 kinase activity and promoting recovery from replication arrest.	Lysine	46-52	cyclin-dependent kinase 9 (CDC2-related kinase)	Mus musculus	38-42
18614053-3	2008	Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of the cohesin complex that physically holds the sister chromatid together, at two conserved lysine residues.	Lysine	188-194	structural maintenance of chromosomes 3	Homo sapiens	77-81
12641448-1	2003	The small ubiquitin-like modifier SUMO-1 is covalently attached to lysine residues on target proteins by a specific conjugation pathway involving the E1 enzyme SAE1/SAE2 and the E2 enzyme Ubc9.	Lysine	67-73	ubiquitin conjugating enzyme E2 I	Homo sapiens	188-192
12641448-2	2003	In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and Ubc9, before the Ubc9.SUMO-1 thiolester complex catalyzes the formation of an isopeptide bond between SUMO-1 and the epsilon-amino group of the target lysine residue on the protein substrate.	Lysine	286-292	small ubiquitin like modifier 1	Homo sapiens	46-52
12641448-2	2003	In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and Ubc9, before the Ubc9.SUMO-1 thiolester complex catalyzes the formation of an isopeptide bond between SUMO-1 and the epsilon-amino group of the target lysine residue on the protein substrate.	Lysine	286-292	ubiquitin conjugating enzyme E2 I	Homo sapiens	152-156
12641448-2	2003	In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and Ubc9, before the Ubc9.SUMO-1 thiolester complex catalyzes the formation of an isopeptide bond between SUMO-1 and the epsilon-amino group of the target lysine residue on the protein substrate.	Lysine	286-292	small ubiquitin like modifier 1	Homo sapiens	157-163
18498352-1	2008	In mammals, G9a is a histone H3 lysine 9 (H3-K9)-specific histone methyltransferase (HMTase), known to be essential for murine embryogenesis.	Lysine	32-38	euchromatic histone lysine N-methyltransferase 2	Mus musculus	12-15
12641448-2	2003	In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and Ubc9, before the Ubc9.SUMO-1 thiolester complex catalyzes the formation of an isopeptide bond between SUMO-1 and the epsilon-amino group of the target lysine residue on the protein substrate.	Lysine	286-292	small ubiquitin like modifier 1	Homo sapiens	157-163
23841748-6	2013	Robust SIX2 mRNA re-expression was confirmed at the protein level by western blot and was associated with epigenetic changes of the histones at multiple sites of the SIX2 promoter leading to gene activation, significantly increased acetylation of histones H4, and methylation of lysine 4 on H3.	Lysine	279-285	SIX homeobox 2	Homo sapiens	7-11
12641448-4	2003	Here we describe methods of both steady-state and half-reaction kinetic analysis of Ubc9, and use these techniques to determine the role of two residues, Asp(100) and Lys(101) of Ubc9 which are not found in E2 enzymes from other protein conjugation pathways.	Lysine	167-170	ubiquitin conjugating enzyme E2 I	Homo sapiens	179-183
12628246-5	2003	Acetylation of the lysine residue in the second AT-hook, which corresponds to Lys65 of HMGA1, has little effect on the DNA binding; so it appears that repression of the hIFNbeta gene, which follows this modification, is not a direct result of the abrogation of DNA binding.	Lysine	19-25	interferon beta 1	Homo sapiens	169-177
18467363-5	2008	Depleters of tissue PIP(2) wortmannin and LY294002 stimulated TRPC6 activity, as did the polycation PIP(2) scavenger poly-L-lysine.	Lysine	117-130	prolactin-inducible protein homolog	Oryctolagus cuniculus	100-103
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	E1A binding protein p300	Homo sapiens	82-86
23850191-5	2013	Mechanistically, monomethylation of lysine 494 of Yap is critical for cytoplasmic retention.	Lysine	36-42	yes-associated protein 1	Mus musculus	50-53
18552833-5	2008	Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP.	Lysine	49-52	E1A binding protein p300	Homo sapiens	217-221
18440710-3	2008	A novel fusogenic, karyophilic immunoporter (fkAb(p75)-ipr) was constructed from the antibody, MC192 (monoclonal antibody to the rat neurotrophin receptor p75NTR, Ab(p75)), poly-l-lysine together with the hemagglutinin 2 and VP1 nuclear localization peptides of influenza and SV40 virus, respectively.	Lysine	173-186	nerve growth factor receptor	Rattus norvegicus	50-53
12456682-4	2003	Like its C-terminal fragment, full-length tetrameric PEX5 exhibits high intrinsic affinity for the PTS1, with a K(d) of 35 nm for the peptide lissamine-Tyr-Gln-Ser-Lys-Leu-COO(-).	Lysine	164-167	peroxisomal biogenesis factor 5	Homo sapiens	53-57
23760262-1	2013	PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis.	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	0-4
12644669-9	2003	The analysis of the putative substrate-binding sites of the pPT, PTh, and NST proteins led to the suggestion that all these proteins share common substrate-binding sites on either side of the membrane each of which contain a conserved Lys residue.	Lysine	235-238	Glucose-6-phosphate/phosphate translocator-like protein	Arabidopsis thaliana	60-63
23720754-1	2013	SET8 (SET domain containing 8) is a histone H4 lysine 20 (H4K20)-specific monomethyltransferase in higher eukaryotes that exerts diverse functions in transcription regulation, DNA repair, tumor metastasis, and genome integrity.	Lysine	47-53	lysine methyltransferase 5A	Homo sapiens	0-4
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Lysine	268-274	ribonuclease A family member 1, pancreatic	Homo sapiens	46-53
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Lysine	268-274	angiogenin	Homo sapiens	58-68
12578357-2	2003	Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in the 434-460 C-terminal segment of RI with the enzymatic active site; Asp435 of RI forms key hydrogen bonds with the catalytic lysine in both complexes, whereas the other contacts are largely distinctive.	Lysine	268-274	angiogenin	Homo sapiens	70-73
18381083-6	2008	A lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine (P site) was found to be critical for peptide substrate recognition by MHCK A, MHCK B and eEF-2K.	Lysine	2-8	eukaryotic elongation factor 2 kinase	Homo sapiens	187-193
23720754-1	2013	SET8 (SET domain containing 8) is a histone H4 lysine 20 (H4K20)-specific monomethyltransferase in higher eukaryotes that exerts diverse functions in transcription regulation, DNA repair, tumor metastasis, and genome integrity.	Lysine	47-53	lysine methyltransferase 5A	Homo sapiens	6-29
18395799-5	2008	Moreover, Foxp3 over-expression induced inactive chromatin structure by decreasing in vivo binding levels of acetylated histone 3 while increasing methylated histone 3 at lysine 9 in the IL-4 genomic locus.	Lysine	171-177	forkhead box P3	Homo sapiens	10-15
23667241-3	2013	METHODS: Anti-EphB4 antibodies (hAb47 and hAb131) were conjugated with the (64)Cu-chelator DOTA through lysine, cysteine, or oligosaccharide on the antibody.	Lysine	104-110	EPH receptor B4	Homo sapiens	14-19
18372281-1	2008	Biotin protein ligase (BPL) catalyzes the biotinylation of the biotin carboxyl carrier protein (BCCP) only at a special lysine residue.	Lysine	120-126	holocarboxylase synthetase	Homo sapiens	0-21
18372281-1	2008	Biotin protein ligase (BPL) catalyzes the biotinylation of the biotin carboxyl carrier protein (BCCP) only at a special lysine residue.	Lysine	120-126	holocarboxylase synthetase	Homo sapiens	23-26
12547786-5	2003	These domains interface at the reactive lysine, Lys84, where trinitrophenylation (TNP-Lys84-S1) was observed in this work to block actin activation of myosin ATPase and in vitro sliding of actin over myosin.	Lysine	40-46	dynein axonemal heavy chain 8	Homo sapiens	158-164
23667241-10	2013	In contrast, (64)Cu-DOTA-Lys-hIgG had a low tumor accumulation, thus demonstrating the target specificity of EphB4-antibody-based probes.	Lysine	25-28	EPH receptor B4	Homo sapiens	109-114
23690534-8	2013	Coimmunoprecipitation and mass spectrometry analyses revealed that MOS9 associates with the Set1 class lysine 4 of histone 3 (H3K4) methyltransferase Arabidopsis Trithorax-Related7 (ATXR7).	Lysine	103-109	hypothetical protein	Arabidopsis thaliana	67-71
12527768-3	2003	Recombinant RNase 7 is ribonucleolytically active against yeast tRNA, as expected from the presence of eight conserved cysteines and the catalytic histidine-lysine- histidine triad which are signature motifs of this superfamily.	Lysine	157-163	ribonuclease A family member 7	Homo sapiens	12-19
12527768-8	2003	Of particular interest, ECP/RNase 3"s cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine.	Lysine	141-147	ribonuclease A family member 7	Homo sapiens	111-118
18445679-5	2008	Trafficking and degradation assays revealed that, similarly to wild-type IL-2Rbeta, an IL-2Rbeta mutant lacking all the cytoplasmic lysine residues is sorted from Hrs-positive early endosomes to LAMP1-positive late endosomes, resulting in degradation of the receptor.	Lysine	132-138	interleukin 2 receptor subunit beta	Homo sapiens	87-96
18463259-2	2008	Through covalent modification of cysteine and lysine residues, TRPA1 can be activated by electrophilic compounds, including active ingredients of pungent natural products (e.g., allyl isothiocyanate), environmental irritants (e.g., acrolein), and endogenous ligands (4-hydroxynonenal).	Lysine	46-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	63-68
23690534-8	2013	Coimmunoprecipitation and mass spectrometry analyses revealed that MOS9 associates with the Set1 class lysine 4 of histone 3 (H3K4) methyltransferase Arabidopsis Trithorax-Related7 (ATXR7).	Lysine	103-109	SET domain-containing protein	Arabidopsis thaliana	92-96
23806337-0	2013	SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.	Lysine	15-21	sirtuin 5	Homo sapiens	0-5
18646558-1	2008	Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.	Lysine	27-33	plasminogen	Homo sapiens	221-228
12473451-10	2003	The higher quality X-ray data for the closed ATP complex (2.2A) provide new structural details likely related to catalysis, including an extension of the KMSKS loop that engages the second lysine and serine residues, K195 and S196, with the alpha and gamma-phosphates; interactions of the K111 side-chain with the gamma-phosphate; and a water molecule bridging the consensus sequence residue T15 to the beta-phosphate.	Lysine	189-195	ATPase phospholipid transporting 8A2	Homo sapiens	45-48
23806337-2	2013	The mitochondrial sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines.	Lysine	82-89	sirtuin 5	Homo sapiens	26-31
12532156-5	2003	RESULTS: Three common MC3R variants were found: a 17C&gt;A variant, changing Thr6--&gt;Lys in 16%, a 241G&gt;A variant changing Val81--&gt;Ile in 15%, and a -239A&gt;G substitution in the GATA binding site in 21% of the subjects.	Lysine	87-90	melanocortin 3 receptor	Homo sapiens	22-26
18498687-6	2008	Partial least squares regression modeling (PLS-1) of spectral data for macrocycle-lysine guest-host complexes was used to correlate the changes in the fluorescence emission for a set of calibration samples consisting of TBRM in the presence of varying enantiomeric compositions of lysine.	Lysine	82-88	plastin 1	Homo sapiens	43-48
18498687-6	2008	Partial least squares regression modeling (PLS-1) of spectral data for macrocycle-lysine guest-host complexes was used to correlate the changes in the fluorescence emission for a set of calibration samples consisting of TBRM in the presence of varying enantiomeric compositions of lysine.	Lysine	281-287	plastin 1	Homo sapiens	43-48
12482968-5	2003	In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities.	Lysine	155-161	lysine methyltransferase 2C	Homo sapiens	27-31
23806337-7	2013	Lysine succinylation is also present on cytosolic and nuclear proteins; indeed, we show that a substantial fraction of SIRT5 is extramitochondrial.	Lysine	0-6	sirtuin 5	Homo sapiens	119-124
23826228-0	2013	Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.	Lysine	40-46	tyrosine aminotransferase	Homo sapiens	80-83
23826228-2	2013	Previous studies have identified a couple of lysine residues in Tat that are essential for its functions.	Lysine	45-51	tyrosine aminotransferase	Homo sapiens	64-67
23826228-3	2013	In order to analyze the functions of all the lysine residues in Tat, we mutated them individually to alanine, glutamine, and arginine.	Lysine	45-51	tyrosine aminotransferase	Homo sapiens	64-67
12943543-3	2003	All these treatments enhanced expression of a gene encoding a novel proline-rich protein (PRP1) which has C-terminal repetitive sequences containing an unusually high amount of lysine and arginine residues.	Lysine	177-183	uncharacterized protein LOC101210961	Cucumis sativus	68-88
18465072-8	2008	In conclusion, women with a lysine (GG genotype) at position 19 of the OCIL protein displayed lower BMD at femoral neck and at lumbar spine sites than women having an asparagine residue.	Lysine	28-34	C-type lectin domain family 2 member D	Homo sapiens	71-75
23826228-4	2013	Through systematic analysis of the lysine mutants, we discovered several previously unidentified characteristics of Tat.	Lysine	35-41	tyrosine aminotransferase	Homo sapiens	116-119
12943543-3	2003	All these treatments enhanced expression of a gene encoding a novel proline-rich protein (PRP1) which has C-terminal repetitive sequences containing an unusually high amount of lysine and arginine residues.	Lysine	177-183	uncharacterized protein LOC101210961	Cucumis sativus	90-94
23826228-5	2013	We found that lysine acetylation could modulate the subcellular localization of Tat, in addition to the regulation of its transactivation activity.	Lysine	14-20	tyrosine aminotransferase	Homo sapiens	80-83
23826228-6	2013	Our data also revealed that lysine mutations had distinct effects on microtubule assembly and Tat binding to bromodomain proteins.	Lysine	28-34	tyrosine aminotransferase	Homo sapiens	94-97
23826228-8	2013	Our findings suggest that Tat may regulate diverse cellular activities through binding to different proteins and that the acetylation of distinct lysine residues in Tat may modulate its interaction with various partners.	Lysine	146-152	tyrosine aminotransferase	Homo sapiens	165-168
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	27-34	small ubiquitin like modifier 1	Homo sapiens	142-148
23576563-2	2013	p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage.	Lysine	21-27	lysine acetyltransferase 8	Homo sapiens	77-81
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	36-39	small ubiquitin like modifier 1	Homo sapiens	142-148
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	49-52	small ubiquitin like modifier 1	Homo sapiens	142-148
12501191-3	2002	Substrate specificity often employs a dual recognition strategy in which the sequence flanking the phospho-acceptor site (Ser.Pro.X.Arg/Lys) is recognized by CDK2, while the cyclin A component of the complex contains a hydrophobic site that binds Arg/Lys.X.Leu ("RXL" or "KXL") substrate recruitment motifs.	Lysine	136-139	cyclin dependent kinase 2	Homo sapiens	158-162
23576563-2	2013	p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage.	Lysine	21-27	lysine acetyltransferase 8	Homo sapiens	83-87
12354770-5	2002	Here, we report that ARNT is modified by SUMO-1 chiefly at Lys(245) within the PAS domain of this protein, both in vivo and in vitro.	Lysine	59-62	small ubiquitin like modifier 1	Homo sapiens	41-47
18319261-3	2008	The histone methyltransferase SET8 (also known as Pr-Set7) was previously reported to monomethylate Lys(20) of histone H4.	Lysine	100-103	lysine methyltransferase 5A	Homo sapiens	30-34
18319261-3	2008	The histone methyltransferase SET8 (also known as Pr-Set7) was previously reported to monomethylate Lys(20) of histone H4.	Lysine	100-103	lysine methyltransferase 5A	Homo sapiens	50-57
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiogenin	Homo sapiens	0-3
18319261-5	2008	Here, we provide evidence to support that SET8 monomethylates Lys(20) of histone H4 during S phase by tethering to proliferating cell nuclear antigen via a putative proliferating cell nuclear antigen-interacting protein box.	Lysine	62-65	lysine methyltransferase 5A	Homo sapiens	42-46
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Lysine	220-223	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Lysine	220-223	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Lysine	220-223	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiotensin II receptor type 1	Homo sapiens	13-16
18336814-3	2008	Members of the PIAS family of proteins enhance Gsc sumoylation and this modification occurs on at least six lysine residues.	Lysine	108-114	goosecoid homeobox	Homo sapiens	47-50
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiotensin II receptor type 2	Homo sapiens	21-24
12392717-11	2002	Thus, CaM-kinase IV activated by binding Ca2+/CaM can bind and phosphorylate another CaM with the aid of poly(Lys), leading to a decrease in the activity of CaM.	Lysine	110-113	calcium/calmodulin dependent protein kinase IV	Homo sapiens	6-19
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiotensin II receptor type 1	Homo sapiens	111-114
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiogenin	Homo sapiens	149-152
23755216-7	2013	Ang II binds AT1 and AT2 through a conserved initial binding mode involving amino acids 111 (consensus 325) of AT1 (Asn) interacting with Tyr (4) of Ang II and 199 and 256 (consensus 512 and 621, a Lys and His respectively) interacting with Phe (8) of Ang II.	Lysine	198-201	angiogenin	Homo sapiens	149-152
12379365-4	2002	The identified cleavage sites are evenly spread throughout the FVIII molecule and are located after an arginine or a lysine in most cases.	Lysine	117-123	coagulation factor VIII	Homo sapiens	63-68
23416531-2	2013	The predominant functional species is a non-covalent heterodimer of 33 and 13kDa, termed Xa33/13, which has predicted newly exposed C-terminal lysines that are important for tissue plasminogen activator (tPA)-mediated plasminogen activation to plasmin.	Lysine	143-150	plasminogen	Homo sapiens	181-188
18413738-0	2008	MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells.	Lysine	63-69	mucin 1, cell surface associated	Homo sapiens	0-4
18413738-3	2008	Herein, we provide the first report that MUC1 gene expression is regulated by DNA methylation and histone H3 lysine 9 (H3-K9) modification of the MUC1 promoter.	Lysine	109-115	mucin 1, cell surface associated	Homo sapiens	41-45
18413738-3	2008	Herein, we provide the first report that MUC1 gene expression is regulated by DNA methylation and histone H3 lysine 9 (H3-K9) modification of the MUC1 promoter.	Lysine	109-115	mucin 1, cell surface associated	Homo sapiens	146-150
23576556-2	2013	BET proteins are recruited on transcriptionally active chromatin via their two N-terminal bromodomains (BRD), a protein interaction module that specifically recognizes acetylated lysine residues in histones H3 and H4.	Lysine	179-185	delta/notch like EGF repeat containing	Homo sapiens	0-3
12363465-6	2002	In the MDS group, we found one patient with a conserved mutation (Lys--&gt;Arg) in the forked head-associated (FHA) domain of the CHK2 coding sequence.	Lysine	66-69	checkpoint kinase 2	Homo sapiens	130-134
23007842-2	2013	Later, it turned out that the homologous mammalian proteins SUMO1 to SUMO4 are reversible protein modifiers that can form isopeptide bonds with lysine residues of respective target proteins (Mahajan et al.	Lysine	144-150	small ubiquitin like modifier 1	Homo sapiens	60-65
12453427-5	2002	Lysine 72 of Polbeta was identified as the main target for acetylation by p300.	Lysine	0-6	DNA polymerase beta	Homo sapiens	13-20
12453427-5	2002	Lysine 72 of Polbeta was identified as the main target for acetylation by p300.	Lysine	0-6	E1A binding protein p300	Homo sapiens	74-78
18239056-5	2008	In rat H4IIEC3 cells, we observed that ethanol exposure induced SREBP-1c lysine acetylation and SREBP-1c transcriptional activity.	Lysine	73-79	sterol regulatory element binding transcription factor 1	Rattus norvegicus	64-72
18358708-3	2008	Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased HDAC1-C/EBPbeta interaction upon GCN5-mediated lysine acetylation, and the ability of sumoylation to inhibit C/EBPalpha-SWI/SNF interaction.	Lysine	180-186	CCAAT enhancer binding protein beta	Homo sapiens	139-148
23470489-1	2013	Small ubiquitin-like modifier (SUMO1-3) is a small group of proteins that are ligated to lysine residues in target proteins.	Lysine	89-95	small ubiquitin like modifier 1	Homo sapiens	31-38
18023379-2	2008	Most bacteria require either lysine, or its biosynthetic precursor, diaminopimelate (meso-DAP), as a component of the peptidoglycan layer of the cell wall.	Lysine	29-35	death associated protein	Homo sapiens	90-93
18327268-5	2008	Indeed, recombinant Atac2 displays HAT activity in vitro with a preference for acetylating histone H4, and mutation of Atac2 abrogated H4 lysine 16 acetylation in D. melanogaster embryos.	Lysine	138-144	Ada2a-containing complex component 2	Drosophila melanogaster	20-25
18327268-5	2008	Indeed, recombinant Atac2 displays HAT activity in vitro with a preference for acetylating histone H4, and mutation of Atac2 abrogated H4 lysine 16 acetylation in D. melanogaster embryos.	Lysine	138-144	Ada2a-containing complex component 2	Drosophila melanogaster	119-124
12698555-6	2002	Recent study demonstrates the ability of enteropeptidase to hydrolyze peptide bonds formed by carboxyl groups of Lys or Arg residues if less than four but at least one negative charged amino acid residue is in any of substrate P2-P5 positions.	Lysine	113-116	transmembrane serine protease 15	Homo sapiens	41-56
12423248-4	2002	The heparin-resistant binding of [125I]bFGF to TM-BBB4 was significantly inhibited by a cationic polypeptide poly-L-lysine (300 micro m), and compounds which contain a sulfate moiety, e.g. heparin and chondroitin sulfate-B (each 10 micro g/mL).	Lysine	109-122	fibroblast growth factor 2	Mus musculus	39-43
23446148-10	2013	Lastly, post-translational acetylation of key lysine residues within NLSs of HMGB1 affects HMGB1 to promote inflammation; hyperacetylation of HMGB1 shifts its equilibrium from a predominant nuclear location toward a cytosolic and subsequent extracellular presence.	Lysine	46-52	high mobility group box 1	Homo sapiens	77-82
12242305-5	2002	Since the histone methyl-lysine residues recognized by HP1 also serve as substrates for deacetylation by HDACs, the interaction of MITR and HDACs with HP1 provides an efficient mechanism for silencing MEF2 target genes by coupling histone deacetylation and methylation.	Lysine	25-31	myocyte enhancer factor 2A	Homo sapiens	201-205
18201971-4	2008	Wdr5 suppression also resulted in a reduction of histone H3 lysine 4 trimethylation, confirming its critical role in this modification.	Lysine	60-66	WD repeat domain 5	Mus musculus	0-4
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	37-41
23446148-10	2013	Lastly, post-translational acetylation of key lysine residues within NLSs of HMGB1 affects HMGB1 to promote inflammation; hyperacetylation of HMGB1 shifts its equilibrium from a predominant nuclear location toward a cytosolic and subsequent extracellular presence.	Lysine	46-52	high mobility group box 1	Homo sapiens	91-96
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	achaete-scute family bHLH transcription factor 1	Homo sapiens	142-146
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	265-269
12452318-2	2002	About half of Japanese show an extremely high sensitivity to alcohol (ethanol), which is due to a missense mutation from glutamic acid (Glu) to lysine (Lys) at codon 487 in an isoenzyme of aldehyde dehydrogenase (ALDH2) with a low Km.	Lysine	144-150	aldehyde dehydrogenase 2 family member	Homo sapiens	213-218
12452318-2	2002	About half of Japanese show an extremely high sensitivity to alcohol (ethanol), which is due to a missense mutation from glutamic acid (Glu) to lysine (Lys) at codon 487 in an isoenzyme of aldehyde dehydrogenase (ALDH2) with a low Km.	Lysine	152-155	aldehyde dehydrogenase 2 family member	Homo sapiens	213-218
12452318-13	2002	In conclusion, the ALDH2 Lys/Lys genotype is a risk factor for myocardial infarction in Japanese men due to its influence on HDL cholesterol level.	Lysine	25-28	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
23446148-10	2013	Lastly, post-translational acetylation of key lysine residues within NLSs of HMGB1 affects HMGB1 to promote inflammation; hyperacetylation of HMGB1 shifts its equilibrium from a predominant nuclear location toward a cytosolic and subsequent extracellular presence.	Lysine	46-52	high mobility group box 1	Homo sapiens	91-96
24278632-4	2013	Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer.	Lysine	52-58	parathymosin	Homo sapiens	17-21
12242502-6	2002	This was also true of the relA mutant strain during limitation for lysine-tRNA or for leucine; however, during limitation for isoleucine-tRNA (or for isoleucine) the mutant showed a gradual, progressive increase in frameshifting, suggesting an indirect effect.	Lysine	67-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	26-30
12408818-2	2002	Here we present evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in acetylation of Smad7 on two lysine residues in its N terminus.	Lysine	130-136	E1A binding protein p300	Homo sapiens	83-87
12060666-3	2002	In this work, we demonstrate that lysine residues 239, 731, and 788 of GRIP1 serve as principal attachment sites for SUMO-1.	Lysine	34-40	small ubiquitin like modifier 1	Homo sapiens	117-123
18329615-3	2008	Tat directly interacts with the deacetylase domain of SIRT1 and blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of NF-kappaB.	Lysine	107-113	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-149
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Lysine	39-42	nuclear receptor subfamily 1 group H member 4	Homo sapiens	124-127
23546875-7	2013	Well conserved consensus sites at lysine 122 and 275 in the AF-1 and ligand binding domains, respectively, of FXR were subject to SUMOylation in vitro and in vivo.	Lysine	34-40	nuclear receptor subfamily 1 group H member 4	Homo sapiens	110-113
18256536-6	2008	We recently found that a member of the malignant brain tumor (MBT) protein family, L3MBTL1, directly compacts chromatin in a strictly histone lysine methylation dependent fashion.	Lysine	142-148	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	83-90
23630229-4	2013	We show that Sirt1 binds to the Hoxa9 gene, counteracts acetylation of its histone target H4 lysine 16, and in turn promotes polycomb-specific repressive histone modification.	Lysine	93-99	homeobox A9	Homo sapiens	32-37
17704809-4	2008	The initial step of this pathway involves UV-induced association of TIP60 with SUMO-conjugation enzymes and site-specific sumoylation of TIP60 at lysines 430 and 451 via Ubc9.	Lysine	146-153	ubiquitin conjugating enzyme E2 I	Homo sapiens	170-174
12119359-4	2002	Mutant mu2 lacking a cluster of conserved lysine residues fails to bind PI(4,5)P2 and to compete the recruitment of native clathrin/AP-2 to PI(4,5)P2-containing liposomes or to presynaptic membranes.	Lysine	42-48	adaptor related protein complex 1 subunit mu 2	Homo sapiens	7-10
12117743-2	2002	To test this hypothesis, we sought to characterize the lysine (fibrin)-binding function of isolated apo(a) of variable sizes.	Lysine	55-61	lipoprotein(a)	Homo sapiens	100-106
12117743-4	2002	All r-apo(a) preparations displayed similar affinity and specificity for lysine residues on fibrin regardless of size (K(d) 3.6+/-0.3 nmol/L) and inhibited the binding of plasminogen with a similar intensity (IC50 16.8+/-5.4 nmol/L).	Lysine	73-79	lipoprotein(a)	Homo sapiens	6-12
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	206-212	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
12117743-7	2002	However, fibrin-binding specificity of the r-apo(a) preparations and the Lp(a) particles was efficiently neutralized (IC50 0.07 and 4 nmol/L) by a monoclonal antibody directed against the lysine-binding function of kringle IV-10.	Lysine	188-194	lipoprotein(a)	Homo sapiens	45-51
12117743-7	2002	However, fibrin-binding specificity of the r-apo(a) preparations and the Lp(a) particles was efficiently neutralized (IC50 0.07 and 4 nmol/L) by a monoclonal antibody directed against the lysine-binding function of kringle IV-10.	Lysine	188-194	lipoprotein(a)	Homo sapiens	73-78
18230726-5	2008	Down-regulation of both MICA and AICL requires the ubiquitin E3 ligase activity of K5 to target substrate cytoplasmic tail lysine residues.	Lysine	123-129	C-type lectin domain family 2 member B	Homo sapiens	33-37
18230726-6	2008	The common MICA *008 allele has a frameshift mutation leading to a premature stop codon and is resistant to down-regulation because of the loss of lysine residues.	Lysine	147-153	MHC class I polypeptide-related sequence A	Homo sapiens	11-15
12060683-4	2002	Here, we have analysed the transcriptional activity of a Hoxa1(NA-KR) mutant for which the asparagine and alanine residues of the homeodomain have been replaced by lysine and arginine, respectively.	Lysine	164-170	homeobox A1	Homo sapiens	57-62
18039665-1	2008	VEK-30, a 30-amino acid internal peptide present within a streptococcal M-like plasminogen (Pg)-binding protein (PAM) from Gram-positive group-A streptococci (GAS), represents an epitope within PAM that shows high affinity for the lysine binding site (LBS) of the kringle-2 (K2) domain of human (h)Pg.	Lysine	231-237	peptidylglycine alpha-amidating monooxygenase	Mus musculus	113-116
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	206-212	nuclear receptor binding SET domain protein 1	Homo sapiens	175-179
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	333-339	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
23592277-1	2013	NSD1 and EZH2 are SET domain-containing histone methyltransferases that play key roles in the regulation of transcription through histone modification and chromatin modeling: NSD1 preferentially methylates lysine residue 36 of histone 3 (H3K36) and is primarily associated with active transcription, while EZH2 shows specificity for lysine residue 27 (H3K27) and is associated with transcriptional repression.	Lysine	333-339	nuclear receptor binding SET domain protein 1	Homo sapiens	175-179
23646112-6	2013	In contrast, young neurons cultured on a slower growth substrate, poly-L-lysine, show significantly reduced axonal and dendritic motility in Lrrk2 transgenic neurons and significantly increased motility in Lrrk2 knockout neurons with no significant changes in length.	Lysine	66-79	leucine-rich repeat kinase 2	Mus musculus	141-146
18946766-0	2008	A single mutation at lysine 241 alters expression and trafficking of the D2 dopamine receptor.	Lysine	21-27	dopamine receptor D2	Homo sapiens	73-93
12222675-5	2002	In membrane fractions of these cells we identified two distinct proteolytic activities responsible for TfR cleavage within the stalk at either Val-108 or Lys-95.	Lysine	154-157	transferrin receptor	Homo sapiens	103-106
12036916-6	2002	In these two cell lines, the acquired BG resistance resulted from two de novo and different mutations at amino acid 165 in AGT: 165-lysine (K) to glutamic acid (E) (K165E in HCT116), and 165-lysine to asparagine (N) (K165N in HCT15).	Lysine	132-138	angiotensinogen	Cricetulus griseus	123-126
23646112-6	2013	In contrast, young neurons cultured on a slower growth substrate, poly-L-lysine, show significantly reduced axonal and dendritic motility in Lrrk2 transgenic neurons and significantly increased motility in Lrrk2 knockout neurons with no significant changes in length.	Lysine	66-79	leucine-rich repeat kinase 2	Mus musculus	206-211
17942747-4	2008	Conservative mutation of Arg(38(1.35)) to lysine had less effect, giving reduced affinities of GnRH I and GnRH II by 24- and 54-fold, respectively.	Lysine	42-48	gonadotropin releasing hormone 1	Homo sapiens	95-99
17942747-4	2008	Conservative mutation of Arg(38(1.35)) to lysine had less effect, giving reduced affinities of GnRH I and GnRH II by 24- and 54-fold, respectively.	Lysine	42-48	gonadotropin releasing hormone 2	Homo sapiens	106-113
23504321-10	2013	SDC1 interacts with the hydrophobic face of lacritin via Leu-108/Leu-109/Phe-112 as well as with Glu-103/Lys-107 and Lys-111 of the largely cationic face.	Lysine	105-108	syndecan 1	Homo sapiens	0-4
17942747-6	2008	Mutation of Arg(38(1.35)) to lysine or alanine had much smaller effect on receptor affinity for [Pro(9)-NHEt]GnRH analogs and no effect on binding affinity of peptide antagonist cetrorelix.	Lysine	29-35	gonadotropin releasing hormone 1	Homo sapiens	109-113
18158948-5	2008	The resulting pz-alpha-MSH analog reacted with the fac-[(99m)Tc(CO)(3)](+) moiety, giving [Ac-Nle(4),Asp(5),d-Phe(7),Lys(11)(pz-(99m)Tc(CO)(3))]alpha-MSH(4-11) in high yield, high specific activity and high radiochemical purity.	Lysine	117-120	pro-opiomelanocortin-alpha	Mus musculus	17-26
12086618-0	2002	PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.	Lysine	65-71	PR/SET domain containing protein 7	Drosophila melanogaster	0-7
12086618-2	2002	A mutation in Drosophila pr-set7 is lethal: second instar larval death coincides with the loss of H4 lysine 20 methylation, indicating a fundamental role for PR-Set7 in development.	Lysine	101-107	PR/SET domain containing protein 7	Drosophila melanogaster	25-32
17964806-3	2008	We have focused on a lysine mutant of hGST A1:A216K.	Lysine	21-27	glutathione S-transferase alpha 1	Homo sapiens	38-45
23292070-9	2013	Sirt1 activation suppressed glycogen synthase kinase 3 beta acetylation, and a mutation on the GSK3beta-Lys(205) residue mimicking a hypoacetylated form revealed increased activity.	Lysine	104-107	glycogen synthase kinase 3 beta	Rattus norvegicus	95-103
17689169-7	2007	The modification of cysteine and lysine residues by DTNB and TNBS respectively abolished the ability of the enzyme to form an isoindole derivative with OPTA, indicating the participation of cysteine and lysine in the formation of isoindole complex.	Lysine	33-39	dystrobrevin beta	Homo sapiens	52-56
17689169-7	2007	The modification of cysteine and lysine residues by DTNB and TNBS respectively abolished the ability of the enzyme to form an isoindole derivative with OPTA, indicating the participation of cysteine and lysine in the formation of isoindole complex.	Lysine	203-209	dystrobrevin beta	Homo sapiens	52-56
11850427-4	2002	Introduction of exogenous Brm to these cells suppressed recruitment of protein complexes containing YY1 and histone deacetylase (HDAC) 1 and 2 to the 5"-long terminal repeat region of the integrated provirus, leading to the enhancement of acetylation of specific lysine residues in histone H4 located in this region.	Lysine	263-269	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	26-29
23327722-2	2013	TAFI suppresses fibrinolysis by removing carboxy-terminal lysine residues from partially degraded fibrin.	Lysine	58-64	carboxypeptidase B2	Homo sapiens	0-4
12029489-1	2002	Elafin, a bifunctional protein, has the NH(2)-terminal domain functions as a transglutaminase substrate for crosslinking to lysine-containing proteins and the COOH-terminal whey acidic protein domain as a potent anti-elastase.	Lysine	124-130	peptidase inhibitor 3	Homo sapiens	0-6
17711404-7	2007	Extensive mutational analysis of individual lysine residues revealed that ubiquitinated lysine residues are located in the N-terminal region of Cidea, as alteration of these lysine residues to alanine (N-5KA mutant) renders Cidea much more stable when compared with wild-type or C-terminal lysine-less mutant (C-5KA).	Lysine	44-50	cell death inducing DFFA like effector a	Homo sapiens	144-149
17711404-7	2007	Extensive mutational analysis of individual lysine residues revealed that ubiquitinated lysine residues are located in the N-terminal region of Cidea, as alteration of these lysine residues to alanine (N-5KA mutant) renders Cidea much more stable when compared with wild-type or C-terminal lysine-less mutant (C-5KA).	Lysine	88-94	cell death inducing DFFA like effector a	Homo sapiens	144-149
17711404-7	2007	Extensive mutational analysis of individual lysine residues revealed that ubiquitinated lysine residues are located in the N-terminal region of Cidea, as alteration of these lysine residues to alanine (N-5KA mutant) renders Cidea much more stable when compared with wild-type or C-terminal lysine-less mutant (C-5KA).	Lysine	88-94	cell death inducing DFFA like effector a	Homo sapiens	144-149
17711404-7	2007	Extensive mutational analysis of individual lysine residues revealed that ubiquitinated lysine residues are located in the N-terminal region of Cidea, as alteration of these lysine residues to alanine (N-5KA mutant) renders Cidea much more stable when compared with wild-type or C-terminal lysine-less mutant (C-5KA).	Lysine	88-94	cell death inducing DFFA like effector a	Homo sapiens	144-149
17898049-5	2007	Treatment of E7-expressing cells with interferon ultimately resulted in cellular senescence through a process that is dependent upon acetylation of p53 by p300/CBP at lysine 382.	Lysine	167-173	E1A binding protein p300	Homo sapiens	155-159
12007600-5	2002	Therefore, the overall inhibition of EACA on prourokinase-induced plasminogen activation was mainly due to inhibition of reactions 2 and 3, by blocking the high-affinity lysine binding interaction between plasmin and prourokinase, as well as between plasminogen and urokinase.	Lysine	170-176	plasminogen	Homo sapiens	66-73
22211733-1	2013	An experiment was conducted to evaluate the effect of excess levels of Leu and Lys on the expression of b(0,+) and CAT-1 mRNA in jejunum, liver and the muscles Longissimus dorsi (LDM) and Semitendinosus (STM).	Lysine	79-82	solute carrier family 7 member 1	Sus scrofa	115-120
11956295-4	2002	However, the pigeon peptide has an alanine at p9 shifting the lysine to p10.	Lysine	62-68	S100 calcium binding protein A10 (calpactin)	Mus musculus	72-75
11959093-2	2002	Photolabeling of eIF4E with [gamma-32P]8-azidoguanosine 5"-triphosphate (8-N3GTP) demonstrated cross-linking at Lys-119 in the S4-H2 loop which is distant from the m7GTP binding site [Marcotrigiano et al.	Lysine	112-115	eukaryotic translation initiation factor 4E	Homo sapiens	17-22
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	checkpoint kinase 2	Homo sapiens	276-280
22211733-8	2013	CAT-1 expression in STM increased by high Lys (p = 0.023) and Leu (p = 0.007) levels.	Lysine	42-45	solute carrier family 7 member 1	Sus scrofa	0-5
22211733-9	2013	In liver, the expression of CAT-1 substantially increased (p = 0.001) because of Lys.	Lysine	81-84	solute carrier family 7 member 1	Sus scrofa	28-33
23524951-5	2013	In this condition, AMBRA1, interacting with the E3-ligase TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its subsequent stabilization, self-association and function.	Lysine	97-100	unc-51 like autophagy activating kinase 1	Homo sapiens	74-78
17999052-6	2007	A three-dimensional homology model of the hH(2)R predicted Lys-173 and Lys-175, adjacent to Cys-174 in e2, to be in close proximity to the binding pocket of guanidine-type agonists.	Lysine	59-62	histamine receptor H2	Homo sapiens	42-48
17999052-6	2007	A three-dimensional homology model of the hH(2)R predicted Lys-173 and Lys-175, adjacent to Cys-174 in e2, to be in close proximity to the binding pocket of guanidine-type agonists.	Lysine	71-74	histamine receptor H2	Homo sapiens	42-48
17980595-3	2007	Plant polycomb proteins FIE, VRN2, CLF, and SWN, together with VIN3, form a complex that adds histone H3 lysine 27 methylation at FLC in vernalized plants.	Lysine	105-111	Fibronectin type III domain-containing protein	Arabidopsis thaliana	63-67
11939812-16	2002	In 3 of these 9 families, a heterozygous glutamic acid and lysine mutation, E337K, was identified in the L2 linker region of K6HF.	Lysine	59-65	keratin 75	Homo sapiens	125-129
23394999-5	2013	We further found that histone H4 was polyneddylated in response to DNA damage, and NEDD8 was conjugated to the N-terminal lysine residues of H4.	Lysine	122-128	NEDD8 ubiquitin like modifier	Homo sapiens	83-88
11907324-5	2002	In pepscan assays, the binding sites of Daxx to PUUV-N were mapped further to two lysine-rich regions, of which one overlaps the sequence of the predicted nuclear localization signal of Daxx.	Lysine	82-88	death domain associated protein	Homo sapiens	40-44
11907324-5	2002	In pepscan assays, the binding sites of Daxx to PUUV-N were mapped further to two lysine-rich regions, of which one overlaps the sequence of the predicted nuclear localization signal of Daxx.	Lysine	82-88	death domain associated protein	Homo sapiens	186-190
17848561-2	2007	The serine/threonine kinase WNK1 (with no K (lysine)) has recently been implicated in exocytosis and is expressed in all three of these cell types.	Lysine	45-51	WNK lysine deficient protein kinase 1	Homo sapiens	28-32
23519409-7	2013	During this process, VPS9a directly interacts with the beta-phosphate of GDP and the P-loop lysine of ARA7 via a catalytically important aspartate finger, which promotes the release of GDP from ARA7.	Lysine	92-98	Ras-related small GTP-binding family protein	Arabidopsis thaliana	102-106
17996705-3	2007	Here we show that the acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains.	Lysine	41-47	TATA-box binding protein associated factor 1	Homo sapiens	106-110
17996705-4	2007	UV irradiation of cells diacetylates p53 at lysines 373 and 382, which in turn recruits TAF1 to a distal p53-binding site on the p21 promoter prior to looping to the core promoter.	Lysine	44-51	TATA-box binding protein associated factor 1	Homo sapiens	88-92
11921231-1	2002	The selective proteolytic activation of the HIV-1 envelope glycoprotein gp160 by furin and other precursor convertases (PCs) occurs at the carboxyl side of the sequence Arg508-Glu-Lys-Arg511 (site 1), in spite of the presence of another consensus sequence: Lys500-Ala-Lys-Arg503 (site 2).	Lysine	180-183	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-77
11921231-1	2002	The selective proteolytic activation of the HIV-1 envelope glycoprotein gp160 by furin and other precursor convertases (PCs) occurs at the carboxyl side of the sequence Arg508-Glu-Lys-Arg511 (site 1), in spite of the presence of another consensus sequence: Lys500-Ala-Lys-Arg503 (site 2).	Lysine	180-183	furin, paired basic amino acid cleaving enzyme	Homo sapiens	81-86
11921231-1	2002	The selective proteolytic activation of the HIV-1 envelope glycoprotein gp160 by furin and other precursor convertases (PCs) occurs at the carboxyl side of the sequence Arg508-Glu-Lys-Arg511 (site 1), in spite of the presence of another consensus sequence: Lys500-Ala-Lys-Arg503 (site 2).	Lysine	257-260	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-77
11921231-1	2002	The selective proteolytic activation of the HIV-1 envelope glycoprotein gp160 by furin and other precursor convertases (PCs) occurs at the carboxyl side of the sequence Arg508-Glu-Lys-Arg511 (site 1), in spite of the presence of another consensus sequence: Lys500-Ala-Lys-Arg503 (site 2).	Lysine	257-260	furin, paired basic amino acid cleaving enzyme	Homo sapiens	81-86
18225649-6	2007	For the same reason, this part of the molecule in different nonnative forms of RNase A is less compact and more flexible and is splitted with the highest rate in the segment 31-39 enriched by long cationic residues Lys and Arg.	Lysine	215-218	ribonuclease A family member 1, pancreatic	Homo sapiens	79-86
23519409-7	2013	During this process, VPS9a directly interacts with the beta-phosphate of GDP and the P-loop lysine of ARA7 via a catalytically important aspartate finger, which promotes the release of GDP from ARA7.	Lysine	92-98	Ras-related small GTP-binding family protein	Arabidopsis thaliana	194-198
23235480-2	2013	However, the involvement of histone acetyl transferases (HATs) and histone deacetylases (HDACs) that regulate epigenetic histone lysine acetylation, and their interaction with TGF-beta1-responsive transcription factors, are not clear.	Lysine	129-135	transforming growth factor, beta 1	Mus musculus	176-185
17440973-5	2007	PIAS1 enhanced the SUMOylation at lysine 396 of mouse SOX9.	Lysine	34-40	SRY (sex determining region Y)-box 9	Mus musculus	54-58
11773077-3	2002	We show that yeast Ada2, Ada3, and Gcn5 form a catalytic core of the ADA and Spt-Ada-Gcn5-acetyltransferase HAT complexes, which is necessary and sufficient in vitro for nucleosomal HAT activity and lysine specificity of the intact HAT complexes.	Lysine	199-205	chromatin-binding transcription regulator ADA2	Saccharomyces cerevisiae S288C	19-23
11744707-6	2002	Thus lysine 405, which is conserved in all eight mGluRs, likely represents a fundamental recognition residue for ligand binding to the mGluRs.	Lysine	5-11	glutamate metabotropic receptor 1	Homo sapiens	49-55
11744707-6	2002	Thus lysine 405, which is conserved in all eight mGluRs, likely represents a fundamental recognition residue for ligand binding to the mGluRs.	Lysine	5-11	glutamate metabotropic receptor 1	Homo sapiens	135-141
11744707-8	2002	Mutation of lysine 74 in mGluR4, or the analogous lysine in mGluR8, to tyrosine (mimicking mGluR1 at this position) produced a large decrease in binding.	Lysine	12-18	glutamate metabotropic receptor 1	Homo sapiens	91-97
11744707-8	2002	Mutation of lysine 74 in mGluR4, or the analogous lysine in mGluR8, to tyrosine (mimicking mGluR1 at this position) produced a large decrease in binding.	Lysine	50-56	glutamate metabotropic receptor 1	Homo sapiens	91-97
23268205-0	2013	Characterization of the transport of lysine-containing dipeptides by PepT1 orthologs expressed in Xenopus laevis oocytes.	Lysine	37-43	solute carrier family 15 (oligopeptide transporter), member 1 L homeolog	Xenopus laevis	69-74
11861864-11	2002	Lysine 450 is within a sumoylation consensus site (I,V,L)KXE; changing lysine 450 to arginine by point mutation abolishes SUMO-1 modification of IE72.	Lysine	0-6	small ubiquitin like modifier 1	Homo sapiens	122-128
17877703-6	2007	Specific HATs acetylate histone H4K5 (HAM1, HAM2), H4K12 (HAG2), and H3K14 (HAG1), suggesting that acetylation of these lysines may have special regulatory significance.	Lysine	120-127	histone acetyltransferase of the MYST family 1	Arabidopsis thaliana	38-42
23242650-0	2013	G9a co-localized with histone H3 lysine 9 monomethylation but not dimethylation in a nuclear membrane-dependent manner during mouse preimplantation embryo development.	Lysine	33-39	euchromatic histone lysine N-methyltransferase 2	Mus musculus	0-3
17877703-6	2007	Specific HATs acetylate histone H4K5 (HAM1, HAM2), H4K12 (HAG2), and H3K14 (HAG1), suggesting that acetylation of these lysines may have special regulatory significance.	Lysine	120-127	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	76-80
17924656-8	2007	Focusing on BMP-3"s preference for ActRIIb, we find that Lys-76 of ActRII and the structurally equivalent Glu-76 of ActRIIb are distinct between the two receptors.	Lysine	57-60	bone morphogenetic protein 3	Homo sapiens	12-17
17936707-4	2007	LXR acetylation is evident at a single conserved lysine (K432 in LXRalpha and K433 in LXRbeta) adjacent to the ligand-regulated activation domain AF2.	Lysine	49-55	nuclear receptor subfamily 1 group H member 3	Homo sapiens	65-73
11853435-7	2002	The major pathway involves gamma-proton removal, tautomerization into the PLP ring, followed by Michael addition of an active site lysine residue at the conjugated vinyl group to give a stable covalent adduct with the protein (Scheme 2, pathway a).	Lysine	131-137	pyridoxal phosphatase	Homo sapiens	74-77
11829753-4	2002	Fluorescence resonance energy transfer (RET) from PM bound to cysteine residues associated with Glu(40), Lys(47) and Lys(58) of fragments of the inhibitor protein (IF(1)) with CPM-F(1) occurred with an efficiency of approx.	Lysine	105-108	ATP synthase inhibitory factor subunit 1	Homo sapiens	164-169
11829753-4	2002	Fluorescence resonance energy transfer (RET) from PM bound to cysteine residues associated with Glu(40), Lys(47) and Lys(58) of fragments of the inhibitor protein (IF(1)) with CPM-F(1) occurred with an efficiency of approx.	Lysine	117-120	ATP synthase inhibitory factor subunit 1	Homo sapiens	164-169
17936708-1	2007	Recent studies have shown that PRC1-like Polycomb repressor complexes monoubiquity-late chromatin on histone H2A at lysine residue 119.	Lysine	116-122	protein regulator of cytokinesis 1	Homo sapiens	31-35
23273925-2	2013	In Arabidopsis, two MYST histone acetyltransferases HAM1 and HAM2 work redundantly to acetylate histone H4 lysine 5 (H4K5ace) in vitro.	Lysine	107-113	histone acetyltransferase of the MYST family 1	Arabidopsis thaliana	52-56
17923079-3	2007	Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.	Lysine	97-103	chromobox 3	Homo sapiens	140-172
11784781-9	2002	Replacement of histidines 147 and 151 with tyrosine and lysine residues conferred this neuroprotective Cu phenotype to human APP, APLP2, and Xenopus APP CuBD peptides.	Lysine	56-62	amyloid beta precursor like protein 2	Homo sapiens	130-135
23224434-5	2013	Furthermore, menin could repress p65 acetylation through recruitment of Sirt1, an enzyme that deacetylases p65 in lysine 310 (K310).	Lysine	114-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	33-36
11675391-2	2002	Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the SCF-ROC1 E3 ubiquitin ligase, selectively stimulates Cdc34-catalyzed lysine 48-linked multiubiquitin chain assembly.	Lysine	148-154	NEDD8 ubiquitin like modifier	Homo sapiens	39-44
17634397-1	2007	Point mutations in WNK4 [for With No K (lysine)], a serine-threonine kinase that is expressed in the distal nephron of the kidney, are linked to familial hyperkalemic hypertension (FHH).	Lysine	40-46	WNK lysine deficient protein kinase 4	Mus musculus	19-23
17917251-2	2007	A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3 is acetylated at Lys-685 by histone acetyltransferase p300, and that acetylation at Lys-685 is critical for STAT3 activation.	Lysine	154-157	E1A binding protein p300	Homo sapiens	191-195
23224434-5	2013	Furthermore, menin could repress p65 acetylation through recruitment of Sirt1, an enzyme that deacetylases p65 in lysine 310 (K310).	Lysine	114-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-110
17682057-4	2007	We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNMT1) complexes to Cyp1a1 promoter chromatin and inhibits histone marks induced by AHR-mediated gene transactivation, including phosphorylation of histone H3 Ser-10, trimethylation of H3 Lys-4, and various acetylation marks in histones H3 and H4.	Lysine	275-278	aryl hydrocarbon receptor	Homo sapiens	171-174
11675391-2	2002	Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the SCF-ROC1 E3 ubiquitin ligase, selectively stimulates Cdc34-catalyzed lysine 48-linked multiubiquitin chain assembly.	Lysine	148-154	cullin 1	Homo sapiens	53-57
23103380-6	2013	The functional role of these lysine residues was assessed evaluating specific Plg-binding activity of the mutated proteins.	Lysine	29-35	plasminogen	Homo sapiens	78-81
11928826-0	2002	Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.	Lysine	58-64	lipoprotein(a)	Homo sapiens	0-17
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	4-10	transient receptor potential cation channel subfamily M member 8	Homo sapiens	136-141
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	4-10	transient receptor potential cation channel subfamily M member 8	Homo sapiens	233-238
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	75-81	transient receptor potential cation channel subfamily M member 8	Homo sapiens	136-141
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	75-81	transient receptor potential cation channel subfamily M member 8	Homo sapiens	233-238
17540777-3	2007	The integrin recognizes a tripeptide motif in a small disulfide-bonded loop at the N terminus of the lectin head region of CD23, centered around Arg(172), Lys(173), and Cys(174) (RKC).	Lysine	155-158	Fc epsilon receptor II	Homo sapiens	123-127
11751969-5	2002	As predicted based on the crystal structures, the majority of the CII-peptide binding affinity for DR1 and DR4 is controlled by the Phe(263); however, unexpectedly the adjacent Lys(264) also contributed significantly to the binding affinity of the peptide.	Lysine	177-180	serpin family D member 1	Homo sapiens	66-69
23283977-7	2013	We demonstrate that the G9a-specific inhibitor BIX01294 abolishes suppression of the Fgf21 promoter activity by E4BP4, whereas overexpression of E4bp4 leads to increased levels of dimethylation of histone 3 lysine 9 (H3K9me2) around the Fgf21 promoter region.	Lysine	207-213	nuclear factor, interleukin 3, regulated	Mus musculus	145-150
23393264-2	2013	Here, we show in Drosophila that a point mutation in lysine 27 of histone H3 (H3-K27) fails to repress transcription of genes that are normally repressed by Polycomb repressive complex 2 (PRC2), the methyltransferase that modifies H3-K27.	Lysine	53-59	Polycomb	Drosophila melanogaster	157-165
12658774-6	2002	Urokinase didn"t bind to Ann-II, demonstrating the role of receptor-related lysine residues on activation of PLG, showing that the Ann-II-PLG interaction was dependent upon carboxyl-terminal lysine residues.	Lysine	191-197	plasminogen	Homo sapiens	138-141
11713475-7	2001	These conformations allow different glutamate residues in the central region of Tcf4 to form a salt bridge with the same critical charged button, Lys 312 of beta-catenin.	Lysine	146-149	transcription factor 4	Homo sapiens	80-84
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
23385743-0	2013	Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.	Lysine	106-112	AGD2-like defense response protein 1	Arabidopsis thaliana	13-17
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17526739-9	2007	Importantly, we identified six lysine residues in the C-terminal domain of Rpb1 as ubiquitin acceptor sites mediated by Wwp2.	Lysine	31-37	WW domain containing E3 ubiquitin protein ligase 2	Mus musculus	120-124
11581253-3	2001	Mutants lacking the SOD1 polypeptide (sod1Delta) and lys7Delta yeast show very similar phenotypes, namely poor growth in air and aerobic auxotrophies for lysine and methionine.	Lysine	154-160	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	20-24
11581253-3	2001	Mutants lacking the SOD1 polypeptide (sod1Delta) and lys7Delta yeast show very similar phenotypes, namely poor growth in air and aerobic auxotrophies for lysine and methionine.	Lysine	154-160	copper chaperone CCS1	Saccharomyces cerevisiae S288C	53-62
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-35	ubiquitin	Saccharomyces cerevisiae S288C	52-61
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-35	ubiquitin	Saccharomyces cerevisiae S288C	77-86
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-35	ubiquitin	Saccharomyces cerevisiae S288C	77-86
17548468-4	2007	Here we report that the small ubiquitin-like protein SUMO-1 can modify MafB in vitro and in vivo on lysines 32 and 297.	Lysine	100-107	small ubiquitin like modifier 1	Homo sapiens	53-59
23385743-2	2013	Conversely, ALD1, a close homologue of DAP-AT in plants, uses lysine as a substrate in vitro.	Lysine	62-68	AGD2-like defense response protein 1	Arabidopsis thaliana	12-16
23388825-3	2013	Ing1 functions by recruiting the regulator of DNA demethylation growth arrest and DNA damage protein 45a (Gadd45a) to histone H3 trimethylated at Lys 4 (H3K4me3).	Lysine	146-149	growth arrest and DNA damage inducible alpha	Homo sapiens	106-113
11585814-0	2001	Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.	Lysine	40-47	histone acetyltransferase 1	Homo sapiens	76-80
23314815-8	2013	The major ubiquitination target of Arabidopsis PCNA, conserved in eukaryotes, is lysine 164.	Lysine	81-87	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	47-51
17592039-6	2007	Deletion of the TUC1 gene together with a deletion of the ELP3 gene, which results in the lack of the mcm(5) side chain, removes all modifications from the wobble uridine derivatives of the cytoplasmic tRNAs specific for Gln, Lys, and Glu, and is lethal to the cell.	Lysine	226-229	Ncs6p	Saccharomyces cerevisiae S288C	16-20
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	61-64	Fc epsilon receptor II	Homo sapiens	4-8
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	61-64	ADAM metallopeptidase domain 10	Homo sapiens	149-155
11514557-3	2001	We report that HSF1 undergoes stress-induced modification at lysine 298 by the small ubiquitin-related protein called SUMO-1.	Lysine	61-67	heat shock transcription factor 1	Homo sapiens	15-19
11514557-3	2001	We report that HSF1 undergoes stress-induced modification at lysine 298 by the small ubiquitin-related protein called SUMO-1.	Lysine	61-67	small ubiquitin like modifier 1	Homo sapiens	118-124
11514557-5	2001	HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of lysine 298.	Lysine	91-97	heat shock transcription factor 1	Homo sapiens	0-4
11514557-5	2001	HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of lysine 298.	Lysine	91-97	small ubiquitin like modifier 1	Homo sapiens	22-28
23314815-9	2013	Taken together, the presented results clearly demonstrate the involvement of Arabidopsis UBC and RAD5a proteins in the ubiquitination of plant PCNA at lysine 164.	Lysine	151-157	DNA/RNA helicase protein	Arabidopsis thaliana	97-102
11514557-6	2001	Mutation of lysine 298 also results in a significant decrease in stress-induced transcriptional activity of HSF1 in vivo.	Lysine	12-18	heat shock transcription factor 1	Homo sapiens	108-112
23314815-9	2013	Taken together, the presented results clearly demonstrate the involvement of Arabidopsis UBC and RAD5a proteins in the ubiquitination of plant PCNA at lysine 164.	Lysine	151-157	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	143-147
17489985-5	2007	Further, compared with subjects having both ADH2 His/His and ALDH2 Glu/Glu, the adjusted OR and its 95% CI for those with both ADH2 Arg/Arg and ALDH2 Glu/Lys was 5.00 (2.32-10.71) in all subjects.	Lysine	154-157	aldehyde dehydrogenase 2 family member	Homo sapiens	144-149
23307557-3	2013	Here we show that TRF2 specifically interacts with the histone acetyltransferase p300, and that p300 acetylates the lysine residue at position 293 of TRF2.	Lysine	116-122	E1A binding protein p300	Homo sapiens	96-100
17489985-9	2007	In conclusion, this case-control study showed a significantly increased risk of SCCHN in subjects with the ADH2 Arg/Arg and ALDH2 Glu/Lys polymorphisms in a Japanese population.	Lysine	134-137	aldehyde dehydrogenase 2 family member	Homo sapiens	124-129
17579066-7	2007	Characterization of this motif using site-directed mutagenesis reveals that a lysine residue in the X position of the Gly-X-Y collagen repeat, Lys(56) in ficolin-A, which is present in all ficolins and MBLs known to activate complement, is essential for MASP-2 binding.	Lysine	78-84	ficolin A	Rattus norvegicus	154-163
17579066-7	2007	Characterization of this motif using site-directed mutagenesis reveals that a lysine residue in the X position of the Gly-X-Y collagen repeat, Lys(56) in ficolin-A, which is present in all ficolins and MBLs known to activate complement, is essential for MASP-2 binding.	Lysine	78-84	MBL associated serine protease 2	Rattus norvegicus	254-260
11514574-9	2001	Consistent with a recent report, we show that nuclear localization of CIITA is enhanced by lysine 144, an in vitro target of pCAF-mediated HAT.	Lysine	91-97	lysine acetyltransferase 2B	Homo sapiens	125-129
11574406-7	2001	Drug activity depended on the presence of intracellular nucleotides and was impaired when the Walker A lysine residues were mutated in either nucleotide-binding domain of SUR2.	Lysine	103-109	ATP binding cassette subfamily C member 9	Homo sapiens	171-175
17579066-7	2007	Characterization of this motif using site-directed mutagenesis reveals that a lysine residue in the X position of the Gly-X-Y collagen repeat, Lys(56) in ficolin-A, which is present in all ficolins and MBLs known to activate complement, is essential for MASP-2 binding.	Lysine	143-146	ficolin A	Rattus norvegicus	154-163
23219734-1	2013	Holocarboxylase synthetase (HLCS) is part of a multiprotein gene repression complex and catalyzes the covalent binding of biotin to lysines (K) in histones H3 and H4, thereby creating rare gene repression marks such as K16-biotinylated histone H4 (H4K16bio).	Lysine	132-139	holocarboxylase synthetase	Homo sapiens	0-26
17579066-7	2007	Characterization of this motif using site-directed mutagenesis reveals that a lysine residue in the X position of the Gly-X-Y collagen repeat, Lys(56) in ficolin-A, which is present in all ficolins and MBLs known to activate complement, is essential for MASP-2 binding.	Lysine	143-146	MBL associated serine protease 2	Rattus norvegicus	254-260
17695015-9	2007	The C-terminal extensions on RpS6 ranged in length from 81 to 190 amino acids, they were highly enriched for lysine and alanine, and they seem to be evolving more rapidly than the conventional portion of the RpS6 protein shared by all eukaryotes.	Lysine	109-115	Ribosomal protein S6	Drosophila melanogaster	29-33
11473115-8	2001	Taken together, our data indicate that Lys(680) is critical for the noncovalent interaction of apo(a) and apoB-100 that precedes covalent Lp(a) formation.	Lysine	39-42	lipoprotein(a)	Homo sapiens	95-101
11473115-8	2001	Taken together, our data indicate that Lys(680) is critical for the noncovalent interaction of apo(a) and apoB-100 that precedes covalent Lp(a) formation.	Lysine	39-42	lipoprotein(a)	Homo sapiens	138-143
11532001-4	2001	We find that an ionic interaction participates in the recognition of the P + 3 position of the substrate and confirms an observation from structural studies indicating that a key element of this recognition is an interaction between the lysine at the P + 3 position and the Thr160 phosphate of Cdk2.	Lysine	237-243	cyclin dependent kinase 2	Homo sapiens	294-298
23219734-1	2013	Holocarboxylase synthetase (HLCS) is part of a multiprotein gene repression complex and catalyzes the covalent binding of biotin to lysines (K) in histones H3 and H4, thereby creating rare gene repression marks such as K16-biotinylated histone H4 (H4K16bio).	Lysine	132-139	holocarboxylase synthetase	Homo sapiens	28-32
23219734-1	2013	Holocarboxylase synthetase (HLCS) is part of a multiprotein gene repression complex and catalyzes the covalent binding of biotin to lysines (K) in histones H3 and H4, thereby creating rare gene repression marks such as K16-biotinylated histone H4 (H4K16bio).	Lysine	132-139	keratin 16	Homo sapiens	219-222
23172365-6	2013	As a proof of concept, the native protein ribonuclease A (RNase A) bearing ten available lysine residues at the surface is furnished with a single azido group at Lys 1 in a highly site-selective fashion yielding azido-(K1)RNase A.	Lysine	89-95	ribonuclease A family member 1, pancreatic	Homo sapiens	42-56
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	E1A binding protein p300	Homo sapiens	40-44
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	lysine acetyltransferase 2B	Homo sapiens	49-53
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	lysine acetyltransferase 2B	Homo sapiens	132-136
17589499-5	2007	Mechanistically, NUP98-NSD1 binds genomic elements adjacent to HoxA7 and HoxA9, maintains histone H3 Lys 36 (H3K36) methylation and histone acetylation, and prevents EZH2-mediated transcriptional repression of the Hox-A locus during differentiation.	Lysine	101-104	nucleoporin 98 and 96 precursor	Homo sapiens	17-22
17589499-5	2007	Mechanistically, NUP98-NSD1 binds genomic elements adjacent to HoxA7 and HoxA9, maintains histone H3 Lys 36 (H3K36) methylation and histone acetylation, and prevents EZH2-mediated transcriptional repression of the Hox-A locus during differentiation.	Lysine	101-104	nuclear receptor binding SET domain protein 1	Homo sapiens	23-27
23172365-6	2013	As a proof of concept, the native protein ribonuclease A (RNase A) bearing ten available lysine residues at the surface is furnished with a single azido group at Lys 1 in a highly site-selective fashion yielding azido-(K1)RNase A.	Lysine	89-95	ribonuclease A family member 1, pancreatic	Homo sapiens	58-65
23172365-6	2013	As a proof of concept, the native protein ribonuclease A (RNase A) bearing ten available lysine residues at the surface is furnished with a single azido group at Lys 1 in a highly site-selective fashion yielding azido-(K1)RNase A.	Lysine	162-165	ribonuclease A family member 1, pancreatic	Homo sapiens	42-56
23172365-6	2013	As a proof of concept, the native protein ribonuclease A (RNase A) bearing ten available lysine residues at the surface is furnished with a single azido group at Lys 1 in a highly site-selective fashion yielding azido-(K1)RNase A.	Lysine	162-165	ribonuclease A family member 1, pancreatic	Homo sapiens	58-65
11445559-3	2001	In Drosophila, a specific modification of H4, acetylation at lysine 16, is enriched at hundreds of sites on the male X chromosome due to the activity of the male-specific lethal (MSL) dosage compensation complex.	Lysine	61-67	male-specific lethal 3	Drosophila melanogaster	179-182
17448460-3	2007	A screen for mutants defective in proliferation and callus formation identified kyp-2-a mutant in the KRYPTONITE (KYP)/SUVH4 gene encoding a histone H3 lysine 9 (H3K9) methyltransferase.	Lysine	152-158	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	119-124
23172365-6	2013	As a proof of concept, the native protein ribonuclease A (RNase A) bearing ten available lysine residues at the surface is furnished with a single azido group at Lys 1 in a highly site-selective fashion yielding azido-(K1)RNase A.	Lysine	162-165	ribonuclease A family member 1, pancreatic	Homo sapiens	222-229
23148227-8	2013	Furthermore, RUNX1 was associated with p300 histone acetyltransferase, and ADR-dependent acetylation of p53 at Lys-373/382 was markedly inhibited in RUNX1 knockdown cells.	Lysine	111-114	E1A binding protein p300	Homo sapiens	39-43
17560369-2	2007	Mitochondrial function(s) of tRNA(Lys)(CUU), tRK1, targeted into Saccharomyces cerevisiae mitochondria was mysterious, since mitochondrial DNA-encoded tRNA(Lys)(UUU), tRK3, was hypothesized to decode both lysine codons, AAA and AAG.	Lysine	205-211	Trk1p	Saccharomyces cerevisiae S288C	45-49
11478887-3	2001	Modeling of the KHD of GC-C indicated that it could adopt a structure similar to that of tyrosine kinases, and sequence comparison with other protein kinases suggested that lysine(516) was positioned in the KHD to interact with ATP.	Lysine	173-179	guanylate cyclase 2C	Homo sapiens	23-27
11498590-3	2001	We show that the accurate execution of the IFN-beta transcriptional switch depends on the ordered acetylation of the high-mobility group I protein HMGI(Y) by PCAF/GCN5 and CBP, which acetylate HMGI(Y) at distinct lysine residues on endogenous promoters.	Lysine	213-219	interferon beta 1	Homo sapiens	43-51
23087373-5	2013	The stimulatory function of HDAC3 for inflammatory gene expression involves a mechanism that uses binding to NF-kappaB p65 and its deacetylation at various lysines.	Lysine	156-163	histone deacetylase 3	Homo sapiens	28-33
16256695-5	2001	The first enzyme, lysine 2,3-aminomutase, is a PLP-dependent enzyme that catalyzes the interconversion of L-lysine to L-beta-lysine using a one-electron-based mechanism utilizing a [4Fe-4S] cluster and S-adenosylmethionine.	Lysine	106-114	pyridoxal phosphatase	Homo sapiens	47-50
17300219-5	2007	Furthermore, p300 acetylates MAML1 and evolutionarily conserved lysine residues in the MAML1 N-terminus are direct substrates for p300-mediated acetylation.	Lysine	64-70	E1A binding protein p300	Homo sapiens	130-134
23087373-5	2013	The stimulatory function of HDAC3 for inflammatory gene expression involves a mechanism that uses binding to NF-kappaB p65 and its deacetylation at various lysines.	Lysine	156-163	RELA proto-oncogene, NF-kB subunit	Homo sapiens	119-122
23148513-2	2013	IDAC-1 and IDAC-3 molecules are conjugates between the I-domain protein and PLP-Cys and Ac-PLP-Cys-NH(2) peptides, respectively, tethered to N-terminus and Lys residues on the I-domain.	Lysine	156-159	proteolipid protein (myelin) 1	Mus musculus	76-79
17131038-3	2007	We performed a case-control study to test the association between two polymorphisms in the polbeta gene: a Pro --&gt; Arg change at codon 242 (the Pro242Arg polymorphism) and a Lys --&gt; Met change at codon 289 (the Lys289Met polymorphism) and breast cancer risk and cancer progression.	Lysine	177-180	DNA polymerase beta	Homo sapiens	91-98
11468363-5	2001	Phosphate binds to the catalytic site of both Ang and Q117G in essentially the same manner observed in the RNase A-phosphate complex, forming hydrogen bonds with the side chains of His 13, His 114, and Gln 12, and the main chain of Leu 115; it makes an additional interaction with the Lys 40 ammonium group in the Ang complex.	Lysine	285-288	angiogenin	Homo sapiens	46-49
11384967-4	2001	Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5.	Lysine	4-11	tyrosine aminotransferase	Homo sapiens	0-3
23148513-2	2013	IDAC-1 and IDAC-3 molecules are conjugates between the I-domain protein and PLP-Cys and Ac-PLP-Cys-NH(2) peptides, respectively, tethered to N-terminus and Lys residues on the I-domain.	Lysine	156-159	proteolipid protein (myelin) 1	Mus musculus	91-94
17353187-6	2007	HSCO specifically associates with histone deacetylase 1 (HDAC1) independently of Mdm2 and facilitates deacetylation of p53 at Lys-373/382 by HDAC1.	Lysine	126-129	ETHE1 persulfide dioxygenase	Homo sapiens	0-4
23159946-9	2013	The temporal expression of JADE1S correlated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3 on lysine 14, demonstrating that the JADE1S-HBO1 complex specifically marks H4 during epithelial cell proliferation.	Lysine	83-90	jade family PHD finger 1	Mus musculus	27-32
17251325-1	2007	Others have shown that H(2)DIDS reversibly and covalently binds to the first lysine (K) in the SKLIK motif at the extracellular end of transmembrane segment 5 of the Cl-HCO(3) exchanger AE1.	Lysine	77-83	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	186-189
11461677-4	2001	In addition, NT-3 and NT-4 sequences contained additional substitutions, including asparagine at position 22, lysine at position 77 and histidine at position 110, that were absent in transmitting mother and consensus subtype B sequences.	Lysine	110-116	3'-nucleotidase	Homo sapiens	13-17
23159946-9	2013	The temporal expression of JADE1S correlated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3 on lysine 14, demonstrating that the JADE1S-HBO1 complex specifically marks H4 during epithelial cell proliferation.	Lysine	83-89	jade family PHD finger 1	Mus musculus	27-32
17212359-8	2007	The return of Lys-Ser-Arg of the AT1R to this hybrid led to almost full recovery of Galphai and Galphaq activation.	Lysine	14-17	angiotensin II receptor type 1	Homo sapiens	33-37
11416128-9	2001	Some of the small ubiquitin-linked peptides that are a hallmark of Doa4 deficiency are not present in rsp5 mutant cells or after overproduction of a variant ubiquitin modified at Lys 63 (UbK63R).	Lysine	179-182	ubiquitin-specific protease DOA4	Saccharomyces cerevisiae S288C	67-71
24018691-2	2013	Here we found evidence that Vba2p mediated ATP-dependent lysine uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae.	Lysine	57-63	Vba2p	Saccharomyces cerevisiae S288C	28-33
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Lysine	44-47	mitogen-activated protein kinase 12	Homo sapiens	139-147
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Lysine	44-47	cyclin dependent kinase 2	Homo sapiens	149-153
23078246-1	2013	Small ubiquitin-like modifier (SUMO1-3) constitutes a group of proteins that conjugate to lysine residues of target proteins thereby modifying their activity, stability, and subcellular localization.	Lysine	90-96	small ubiquitin like modifier 1	Homo sapiens	31-38
11381133-6	2001	The substitution of key lysine residues in the Walker A motifs of TAP1 and TAP2 suggests that TAP1-mediated ATP hydrolysis is not essential for peptide translocation but that TAP2-mediated ATP hydrolysis is critical, not only for translocation, but for peptide binding.	Lysine	24-30	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	75-79
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Lysine	70-73	ectodysplasin A	Homo sapiens	20-23
11416205-6	2001	Here we show that the 50-kDa EDA parent molecule is cleaved at -Arg156Asn-Lys-Arg(159 downward arrow)- to release the soluble C-terminal fragment containing the TNF core domain.	Lysine	74-77	ectodysplasin A	Homo sapiens	29-32
17267393-5	2007	We confirmed, by in vitro labeling and peptide mapping by mass spectrometry, that two previously known acetyltransferases, p300 and CREB-binding protein, could catalyze lysine propionylation and lysine butyrylation in histones.	Lysine	169-175	E1A binding protein p300	Homo sapiens	123-127
17267393-5	2007	We confirmed, by in vitro labeling and peptide mapping by mass spectrometry, that two previously known acetyltransferases, p300 and CREB-binding protein, could catalyze lysine propionylation and lysine butyrylation in histones.	Lysine	195-201	E1A binding protein p300	Homo sapiens	123-127
17427040-6	2007	We have generated mutated versions of the A. thaliana Shaggy-like kinase 3-2 (AtSK3-2), in which Lys(167) and Arg(178), respectively homologues to Lys(85) and Arg(96) of the mammal GSK3beta, were modified into Ala by site-directed mutagenesis.	Lysine	97-100	shaggy-like protein kinase 32	Arabidopsis thaliana	78-85
17427040-6	2007	We have generated mutated versions of the A. thaliana Shaggy-like kinase 3-2 (AtSK3-2), in which Lys(167) and Arg(178), respectively homologues to Lys(85) and Arg(96) of the mammal GSK3beta, were modified into Ala by site-directed mutagenesis.	Lysine	147-150	shaggy-like protein kinase 32	Arabidopsis thaliana	78-85
22890573-8	2013	Interestingly, snapin was ubiquitinated by RNF13 via the lysine-29 conjugated polyubiquitin chain, which in turn promoted the association of snapin with SNAP-25.	Lysine	57-63	SNAP-associated protein	Mus musculus	15-21
17392790-4	2007	The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity.	Lysine	131-134	tripartite motif containing 25	Homo sapiens	36-42
17392790-5	2007	The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction.	Lysine	4-7	tripartite motif containing 25	Homo sapiens	55-61
17392790-7	2007	Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity.	Lysine	65-68	tripartite motif containing 25	Homo sapiens	26-32
11264294-6	2001	We showed that PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144.	Lysine	85-88	pappalysin 2	Homo sapiens	15-22
22890573-8	2013	Interestingly, snapin was ubiquitinated by RNF13 via the lysine-29 conjugated polyubiquitin chain, which in turn promoted the association of snapin with SNAP-25.	Lysine	57-63	SNAP-associated protein	Mus musculus	141-147
11439928-8	2001	In contrast, ATP activated a chimera containing the hIK1 C-terminal amino acids His(299)-Lys(427).	Lysine	89-92	potassium calcium-activated channel subfamily N member 4	Homo sapiens	52-56
17426142-2	2007	By comparison with the previous structures of Kex2 and furin, this structure of the acylated enzyme provides a basis for the observed decrease in the acylation rate with substrates containing a lysine at P(1) and the absence of an effect on the deacylation rate without involving mobility of the S(1) lid.	Lysine	194-200	furin, paired basic amino acid cleaving enzyme	Homo sapiens	46-60
23448461-0	2013	Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.	Lysine	0-6	E1A binding protein p300	Homo sapiens	34-38
17307730-7	2007	Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age-related increase in p53 expression, and increased the rate of p53 degradation.	Lysine	77-83	nicotinamide phosphoribosyltransferase	Homo sapiens	0-5
23448461-4	2013	This review focuses on two highly related epigenetic factors that are directly involved in a number of neurological disorders, the lysine acetyltransferases CREB-binding protein (CBP) and E1A-associated protein p300 (p300).	Lysine	131-137	E1A binding protein p300	Homo sapiens	211-215
17420289-3	2007	Herp-mediated POSH activation requires the Ubl domain and exclusively promotes lysine-63-linked polyubiquitination.	Lysine	79-85	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	0-4
11563935-7	2001	The most potent analog of the series, D-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-NH-CH2-CH2-OH showed the most prolonged activity by inhibiting the release of growth hormone for at least 3 h. The analogs containing D-Phe or D-Tyr at the N-terminus were almost equipotent, which proves that the exocyclic N-terminal residue is not involved directly in the receptor recognition.	Lysine	60-63	gonadotropin releasing hormone receptor	Rattus norvegicus	151-165
23234508-3	2013	The aim of this study is to analyze the efficacy of the CE and HPLC in the detection of Hb H (beta4)-CS/Pakse-E [beta26(B8)Glu Lys, GAG&gt;AAG] disease.	Lysine	127-130	tubulin beta 3 class III	Homo sapiens	94-99
17420289-3	2007	Herp-mediated POSH activation requires the Ubl domain and exclusively promotes lysine-63-linked polyubiquitination.	Lysine	79-85	SH3 domain containing ring finger 1	Homo sapiens	14-18
17420289-5	2007	Substitution of all lysine residues within the Ubl domain abolishes lysine-63-linked polyubiquitination of Herp in vitro and calcium-induced Herp relocalization that is also abrogated by the overexpression of a dominant-negative POSHV14A.	Lysine	20-26	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	107-111
23606839-14	2013	GLP-1 receptor imaging with [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH2]-exendin-4 is able to detect MTC lesions.	Lysine	29-32	glucagon like peptide 1 receptor	Homo sapiens	0-14
17371260-7	2007	Acetylation of NF-kappaB [RelA (p65)] at Lys(310) enhances its transcriptional activity, which is inhibited by SIRT1 deacetylase, type III HDAC (histone deacetylase).	Lysine	41-44	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-35
11485023-0	2001	Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity.	Lysine	154-160	lipoprotein(a)	Homo sapiens	23-40
11485023-0	2001	Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity.	Lysine	154-160	lipoprotein(a)	Homo sapiens	26-40
11485023-2	2001	The kringle IV type 10 of apolipoprotein(a) [apo(a)] is the primary lysine binding site (LBS) of Lp(a) and is associated with lesion formation in transgenic mice.	Lysine	68-74	lipoprotein(a)	Homo sapiens	26-43
11485023-2	2001	The kringle IV type 10 of apolipoprotein(a) [apo(a)] is the primary lysine binding site (LBS) of Lp(a) and is associated with lesion formation in transgenic mice.	Lysine	68-74	lipoprotein(a)	Homo sapiens	97-102
11408592-2	2001	The MAL carboxy terminus ends with the sequence Arg-Trp-Lys-Ser-Ser (RWKSS), which resembles dilysine-based motifs involved in protein sorting.	Lysine	56-59	mal, T cell differentiation protein	Canis lupus familiaris	4-7
24348269-4	2013	Through a combination of yeast two-hybrid analysis and in vitro biochemistry we identified the single C. elegans SUMO (SMO-1) as an NHR-25 interacting protein, and showed that NHR-25 is sumoylated on at least four lysines.	Lysine	214-221	Small ubiquitin-related modifier	Caenorhabditis elegans	119-124
11371211-5	2001	The results showed that isoleucine replacement for lysine in the portal region, including the alphaI- and alphaII-helices and the beta C-D turn, resulted in much slower 2-(9-anthroyloxy)palmitate (2AP) transfer rates to acidic membranes than those of native AFABP.	Lysine	51-57	beta-carotene oxygenase 1	Mus musculus	130-138
11279135-5	2001	p300, but not P/CAF, selectively and directly acetylated the ERalpha at lysine residues within the ERalpha hinge/ligand binding domain.	Lysine	72-78	E1A binding protein p300	Homo sapiens	0-4
11279135-7	2001	These ERalpha lysine residues also regulated transcriptional activation by histone deacetylase inhibitors and p300.	Lysine	14-20	E1A binding protein p300	Homo sapiens	110-114
17267036-4	2007	In Api g 1.01, substitution of lysine against glutamic acid at amino acid position 44, a key residue of the Bet v 1 "P-loop", increased the IgE-binding properties.	Lysine	31-37	delta/notch like EGF repeat containing	Homo sapiens	108-111
24348269-4	2013	Through a combination of yeast two-hybrid analysis and in vitro biochemistry we identified the single C. elegans SUMO (SMO-1) as an NHR-25 interacting protein, and showed that NHR-25 is sumoylated on at least four lysines.	Lysine	214-221	Nuclear hormone receptor family member nhr-25	Caenorhabditis elegans	176-182
17296727-1	2007	Treatment of yeast and human cells with DNA-damaging agents elicits lysine 48-linked polyubiquitylation of Rpb1, the largest subunit of RNA polymerase II (Pol II), which targets Pol II for proteasomal degradation.	Lysine	68-74	RNA polymerase II subunit A	Homo sapiens	107-111
23451270-3	2013	Here we demonstrated that the C-terminus (CT) of AT1R directly and strongly bound to tubulin and the binding domains were mapped to two consecutive Lys residues at positions 310 and 311 in the CT membrane-proximal region of AT1R and the acidic CT of tubulin, suggestive of essentially ionic interactions between AT1R and tubulin.	Lysine	148-151	angiotensin II receptor type 1	Homo sapiens	49-53
17357984-4	2007	This could be explained by modification of lysine residues, being the preferred cleavage site for plasmin, but also the residue generally preferred for lactosylation.	Lysine	43-49	plasminogen	Homo sapiens	98-105
11278664-7	2001	Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity.	Lysine	73-76	cut like homeobox 1	Homo sapiens	172-175
11278668-0	2001	Heparin-binding histidine and lysine residues of rat selenoprotein P.	Lysine	30-36	selenoprotein P	Rattus norvegicus	53-68
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	8-14	keratin 27	Homo sapiens	118-121
11278904-1	2001	The crystal structure of yeast orotidine-5"-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5"-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site.	Lysine	236-239	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	31-67
23451270-3	2013	Here we demonstrated that the C-terminus (CT) of AT1R directly and strongly bound to tubulin and the binding domains were mapped to two consecutive Lys residues at positions 310 and 311 in the CT membrane-proximal region of AT1R and the acidic CT of tubulin, suggestive of essentially ionic interactions between AT1R and tubulin.	Lysine	148-151	angiotensin II receptor type 1	Homo sapiens	224-228
11278904-1	2001	The crystal structure of yeast orotidine-5"-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5"-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site.	Lysine	252-255	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	31-67
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	84-91	keratin 27	Homo sapiens	118-121
23451270-3	2013	Here we demonstrated that the C-terminus (CT) of AT1R directly and strongly bound to tubulin and the binding domains were mapped to two consecutive Lys residues at positions 310 and 311 in the CT membrane-proximal region of AT1R and the acidic CT of tubulin, suggestive of essentially ionic interactions between AT1R and tubulin.	Lysine	148-151	angiotensin II receptor type 1	Homo sapiens	224-228
23451270-5	2013	These data demonstrate for the first time that specific Lys residues in the CT juxtamembrane region regulate the processing of AT1R through interacting with tubulin.	Lysine	56-59	angiotensin II receptor type 1	Homo sapiens	127-131
17369352-8	2007	Comparison with ENCODE-derived data shows that lack of methylation at CpG-rich sequences correlates with presence of the active chromatin mark, histone H3 lysine-4 methylation in the HOXA region.	Lysine	155-161	homeobox A cluster	Homo sapiens	183-187
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	71-74	Kruppel like factor 1	Homo sapiens	0-4
11259590-6	2001	EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain.	Lysine	113-116	Kruppel like factor 1	Homo sapiens	0-4
23383067-5	2013	The single NALCN gene is limited as a sodium channel with a lysine (K)-containing pore in vertebrates, but originally NALCN was a calcium-like channel, and evolved to operate as both a calcium channel and sodium channel for different roles in many invertebrates.	Lysine	60-66	sodium leak channel, non-selective	Homo sapiens	11-16
11259590-7	2001	Although site-specific DNA binding by EKLF is unaffected by the acetylation status of either of these lysines, directed mutagenesis of Lys-288 (but not Lys-302) decreases the ability of EKLF to transactivate the beta-globin promoter in vivo and renders it unable to be superactivated by coexpressed p300 or CBP.	Lysine	102-109	Kruppel like factor 1	Homo sapiens	186-190
11259590-7	2001	Although site-specific DNA binding by EKLF is unaffected by the acetylation status of either of these lysines, directed mutagenesis of Lys-288 (but not Lys-302) decreases the ability of EKLF to transactivate the beta-globin promoter in vivo and renders it unable to be superactivated by coexpressed p300 or CBP.	Lysine	135-138	Kruppel like factor 1	Homo sapiens	186-190
11259590-7	2001	Although site-specific DNA binding by EKLF is unaffected by the acetylation status of either of these lysines, directed mutagenesis of Lys-288 (but not Lys-302) decreases the ability of EKLF to transactivate the beta-globin promoter in vivo and renders it unable to be superactivated by coexpressed p300 or CBP.	Lysine	135-138	E1A binding protein p300	Homo sapiens	299-303
11307806-4	2001	The purpose of this study was to examine the association of Lp(a) concentration, apo(a) size, and Lp(a) lysine-binding site(s) (LBS) function in patients with early onset heart disease, and age-matched controls.	Lysine	104-110	lipoprotein(a)	Homo sapiens	98-103
17197697-2	2007	Although a point mutation changing lysine 134 to arginine (K134R) in IRAK abolished IL-1-induced IRAK ubiquitination and degradation, mutations of serines and threonines adjacent to lysine 134 to alanines ((S/T)A (131-144)) reduced IL-1-induced IRAK phosphorylation and abolished IRAK ubiquitination.	Lysine	35-41	interleukin 1 receptor associated kinase 1	Homo sapiens	69-73
17197697-2	2007	Although a point mutation changing lysine 134 to arginine (K134R) in IRAK abolished IL-1-induced IRAK ubiquitination and degradation, mutations of serines and threonines adjacent to lysine 134 to alanines ((S/T)A (131-144)) reduced IL-1-induced IRAK phosphorylation and abolished IRAK ubiquitination.	Lysine	35-41	interleukin 1 receptor associated kinase 1	Homo sapiens	97-101
17197697-2	2007	Although a point mutation changing lysine 134 to arginine (K134R) in IRAK abolished IL-1-induced IRAK ubiquitination and degradation, mutations of serines and threonines adjacent to lysine 134 to alanines ((S/T)A (131-144)) reduced IL-1-induced IRAK phosphorylation and abolished IRAK ubiquitination.	Lysine	35-41	interleukin 1 receptor associated kinase 1	Homo sapiens	97-101
17197697-2	2007	Although a point mutation changing lysine 134 to arginine (K134R) in IRAK abolished IL-1-induced IRAK ubiquitination and degradation, mutations of serines and threonines adjacent to lysine 134 to alanines ((S/T)A (131-144)) reduced IL-1-induced IRAK phosphorylation and abolished IRAK ubiquitination.	Lysine	35-41	interleukin 1 receptor associated kinase 1	Homo sapiens	97-101
24146614-7	2013	Opposite to the DNA binding site, both kLANA and mLANA CTD contain a characteristic lysine-rich positively charged surface patch, which appears to be a unique feature of gamma2-herpesviral LANA proteins.	Lysine	84-90	LANA	Human gammaherpesvirus 8	40-44
11157057-2	2001	Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.	Lysine	16-22	Pr55(Gag)	Human immunodeficiency virus 1	68-71
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	21-25
11172676-1	2001	Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins.	Lysine	172-179	endothelin receptor type A	Homo sapiens	152-155
17349966-9	2007	A modified path for proton uptake towards the Q(i)-site features a cluster of conserved lysine residues in the cytochrome b (Lys228) and cytochrome c(1) subunits (Lys288, Lys289, Lys296).	Lysine	88-94	cytochrome b	Saccharomyces cerevisiae S288C	111-123
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	84-88
11563698-3	2001	The B haplotype encodes two alpha-globin chains, Ialpha2 and IIalpha4, which differ at positions 10 and 11: Ialpha2 has 10 I1e, 11 Gln, 64 Asn; IIalpha4 has 10 Val, 11 Lys, 64 Asn.	Lysine	168-171	hemoglobin subunit alpha-4-like	Bubalus bubalis	61-69
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	84-88
23095757-4	2012	The SUMOylation sites included three Lys residues on the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and their SUMOylation was catalyzed by Ubc9.	Lysine	37-40	ubiquitin conjugating enzyme E2 I	Homo sapiens	199-203
11330835-2	2001	In this study, the authors have demonstrated for the first time an inhibitory effect of in vitro glycation on the catalytic activity of alanine aminotransferase (ALT, EC 2.6.1.2), a pyridoxal phosphate enzyme with several lysine residues in the molecule.	Lysine	222-228	glutamic--pyruvic transaminase	Homo sapiens	136-160
17332356-5	2007	Here, we show that six lysine-rich regions in several highly conserved functional domains of p300 are targeted by p300HAT for acetylation in cell-free systems.	Lysine	23-29	E1A binding protein p300	Homo sapiens	93-97
17332356-5	2007	Here, we show that six lysine-rich regions in several highly conserved functional domains of p300 are targeted by p300HAT for acetylation in cell-free systems.	Lysine	23-29	E1A binding protein p300	Homo sapiens	114-121
23095757-4	2012	The SUMOylation sites included three Lys residues on the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and their SUMOylation was catalyzed by Ubc9.	Lysine	111-114	ubiquitin conjugating enzyme E2 I	Homo sapiens	199-203
22528876-1	2012	Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in collagens and elastin, resulting in the covalent crosslinking and stabilization of these extracellular matrix (ECM) structural components, thus provide collagen and elastic fibers much of their tensile strength and structural integrity.	Lysine	62-68	lysyl oxidase like 1	Homo sapiens	45-52
17224141-5	2007	Loss-of-function of either AtSWP1 or AtCZS results in reduced dimethylation of lysine 9 and lysine 27 of histone H3 and hyperacetylation of histone H4 within the FLC locus, in elevated FLC mRNA levels, and in moderately delayed flowering.	Lysine	79-85	LSD1-like 1	Arabidopsis thaliana	27-33
17224141-5	2007	Loss-of-function of either AtSWP1 or AtCZS results in reduced dimethylation of lysine 9 and lysine 27 of histone H3 and hyperacetylation of histone H4 within the FLC locus, in elevated FLC mRNA levels, and in moderately delayed flowering.	Lysine	92-98	LSD1-like 1	Arabidopsis thaliana	27-33
11306098-0	2001	Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase.	Lysine	30-33	sepiapterin reductase	Homo sapiens	61-82
11460483-9	2001	Because of this structural/functional homology and enzymatic difference, Lp(a) may compete with plasminogen for binding to lysine residues and impair, thereby, fibrinolysis and pericellular proteolysis.	Lysine	123-129	lipoprotein(a)	Homo sapiens	73-78
16961436-7	2007	Control cells expressing human melanopsin, where the Schiff-base lysine has been mutated to alanine, show no responses to light.	Lysine	65-71	opsin 4	Homo sapiens	31-41
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Lysine	275-281	keratin 1	Homo sapiens	33-36
23197736-2	2012	Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the euchromatic dimethylation of histone H3 at lysine 9 (H3K9me2), has been implicated recently in mediating neural and behavioral plasticity in response to chronic cocaine administration.	Lysine	118-124	euchromatic histone lysine N-methyltransferase 2	Mus musculus	15-18
11438997-7	2001	The G-to-A transition at the consensus sequence of splicing donor site of exon 3 (IVS3+1G&gt;A) resulted in exon 3 skipping of the PTS transcript and caused a frameshift stop after lysine of codon 54 (K54X).	Lysine	181-187	6-pyruvoyltetrahydropterin synthase	Homo sapiens	131-134
17150966-0	2007	The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.	Lysine	27-33	ribonuclease A family member 7	Homo sapiens	52-66
23197736-2	2012	Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the euchromatic dimethylation of histone H3 at lysine 9 (H3K9me2), has been implicated recently in mediating neural and behavioral plasticity in response to chronic cocaine administration.	Lysine	118-124	euchromatic histone lysine N-methyltransferase 2	Mus musculus	20-25
17150966-5	2007	NMR studies showed that the 22 positively charged residues (Lys(18) and Arg(4)) are distributed into three clusters on the surface of hRNase7.	Lysine	60-63	ribonuclease A family member 7	Homo sapiens	134-141
17150966-8	2007	We suggest that the hRNase7 binds to bacterial membrane and renders the membrane permeable through the flexible and clustered Lys residues K(1),K(3),K(111),K(112).	Lysine	126-129	ribonuclease A family member 7	Homo sapiens	20-27
11114935-7	2001	These results, and others, suggest that the interaction of RecA-ssDNA with leucine-101 and arginine-102, together with numerous other contacts between UmuD(2) and the RecA-ssDNA nucleoprotein filaments, serves to realign lysine-97 relative to serine-60, thereby activating UmuD(2) for self-cleavage.	Lysine	221-227	UmuD	Escherichia coli	151-155
22956542-0	2012	Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16.	Lysine	134-140	Histone deacetylase 3	Drosophila melanogaster	13-34
11112487-3	2000	HPLC and immunoblot analysis of the HIV-1 mutants demonstrated that either of the lysines in p6(Gag), K27 or K33, could be monoubiquitinated.	Lysine	82-89	Pr55(Gag)	Human immunodeficiency virus 1	93-100
17141806-5	2007	Instead, lysine at position P(-4) of PD1 substitutes the function of the P(-3) anchor residue.	Lysine	9-15	programmed cell death 1	Homo sapiens	37-40
22956542-4	2012	Further genetic studies showed that Hdac3 counteracted the organ overgrowth induced by overexpression of insulin receptor (InR), phosphoinositide 3-kinase (PI3K) or S6 kinase (S6K), and the growth regulation by Hdac3 was mediated through the deacetylation of histone H4 at lysine 16 (H4K16).	Lysine	273-279	Histone deacetylase 3	Drosophila melanogaster	36-41
17283126-8	2007	Substitution of five lysine residues of RPB8 with arginine residues abolished its ability to be ubiquitinated while preserving its polymerase activity.	Lysine	21-27	RNA polymerase II, I and III subunit H	Homo sapiens	40-44
23007391-5	2012	p300 acetylates lysine residues at the N terminus of the myocardin protein.	Lysine	16-22	E1A binding protein p300	Homo sapiens	0-4
17240993-1	2007	Tissue transglutaminase (TGase) is a Ca2+-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues and is allosterically regulated by GTP.	Lysine	190-193	transglutaminase 1	Homo sapiens	25-30
10964919-4	2000	Recently, we have identified a site in the C-type lectin-like domain of tetranectin, involving Lys-148, Glu-150, and Asp-165, which mediates calcium-sensitive binding to plasminogen kringle 4.	Lysine	95-98	C-type lectin domain family 3 member B	Homo sapiens	72-83
11132853-6	2000	Mucin protein contributed to 19 and 40% of ileal loss of CP and lysine, respectively.	Lysine	64-70	mucin 1, cell surface associated	Bos taurus	0-5
17105732-9	2007	An MR mutant in which four lysine residues within sumoylation motifs were mutated into arginine (K89R/K399R/K494R/K953R) failed to be sumoylated, but Ubc9 similarly enhanced transactivation by the mutant MR, indicating that sumoylation activity is dispensable for coactivation capacity of Ubc9.	Lysine	27-33	nuclear receptor subfamily 3 group C member 2	Homo sapiens	3-5
23091041-5	2012	Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope-DR52c complex, the interface is dominated by the TCR Vbeta CDR3 interaction with the p7 lysine.	Lysine	231-237	CDR3	Homo sapiens	202-206
17052979-1	2007	The Hat1 histone acetyltransferase catalyzes the acetylation of H4 at lysines 5 and 12, the same sites that are acetylated in newly synthesized histone H4.	Lysine	70-77	histone acetyltransferase 1	Homo sapiens	4-8
10961991-5	2000	The major SUMO-1-modified residue in p73alpha is the C-terminal lysine (Lys(627)).	Lysine	64-70	small ubiquitin like modifier 1	Homo sapiens	10-16
10961991-5	2000	The major SUMO-1-modified residue in p73alpha is the C-terminal lysine (Lys(627)).	Lysine	72-75	small ubiquitin like modifier 1	Homo sapiens	10-16
22583696-1	2012	The SET8 histone lysine methyltransferase, which monomethylates the histone 4 lysine 20 residue plays important roles in cell cycle control and genomic stability.	Lysine	17-23	lysine methyltransferase 5A	Homo sapiens	4-8
10961991-6	2000	The sequence surrounding this lysine conforms to a consensus SUMO-1 modification site b(X)XXhKXE, where b is a basic amino acid.	Lysine	30-36	small ubiquitin like modifier 1	Homo sapiens	61-67
10944526-4	2000	In vitro, MyoD is acetylated both by CBP/p300 and by PCAF on two lysines located at the boundary of the DNA binding domain.	Lysine	65-72	lysine acetyltransferase 2B	Homo sapiens	53-57
17110376-0	2007	CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription.	Lysine	70-77	CCAAT enhancer binding protein beta	Homo sapiens	32-43
17110376-0	2007	CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription.	Lysine	70-76	CCAAT enhancer binding protein beta	Homo sapiens	32-43
17110376-5	2007	Analysis of truncations of C/EBPbeta and peptides based on C/EBPbeta sequences identified multiple lysines within C/EBPbeta that can be acetylated.	Lysine	99-106	CCAAT enhancer binding protein beta	Homo sapiens	27-36
17110376-5	2007	Analysis of truncations of C/EBPbeta and peptides based on C/EBPbeta sequences identified multiple lysines within C/EBPbeta that can be acetylated.	Lysine	99-106	CCAAT enhancer binding protein beta	Homo sapiens	59-68
17110376-5	2007	Analysis of truncations of C/EBPbeta and peptides based on C/EBPbeta sequences identified multiple lysines within C/EBPbeta that can be acetylated.	Lysine	99-106	CCAAT enhancer binding protein beta	Homo sapiens	59-68
17110376-6	2007	Among these, a novel acetylation site at lysine 39 of C/EBPbeta was identified.	Lysine	41-47	CCAAT enhancer binding protein beta	Homo sapiens	54-63
22583696-9	2012	Since H4 and p53 both contain the target lysine in an unstructured part of the protein, we conclude that the long recognition sequence of SET8 makes it difficult to methylate a lysine in a folded region of a protein, because amino acid side chains essential for recognition will be buried.	Lysine	41-47	lysine methyltransferase 5A	Homo sapiens	138-142
17110376-8	2007	Different C/EBPbeta-responsive promoters require different patterns of acetylated lysines in C/EBPbeta for transcription activation.	Lysine	82-89	CCAAT enhancer binding protein beta	Homo sapiens	10-19
17110376-8	2007	Different C/EBPbeta-responsive promoters require different patterns of acetylated lysines in C/EBPbeta for transcription activation.	Lysine	82-89	CCAAT enhancer binding protein beta	Homo sapiens	93-102
17110376-10	2007	These data suggest that acetylation of Lys-39 of C/EBPbeta, alone or in combination with acetylation at other lysines, may play a role in C/EBPbeta-mediated transcriptional activation.	Lysine	39-42	CCAAT enhancer binding protein beta	Homo sapiens	49-58
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	Lysine	26-32	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	183-189
22583696-9	2012	Since H4 and p53 both contain the target lysine in an unstructured part of the protein, we conclude that the long recognition sequence of SET8 makes it difficult to methylate a lysine in a folded region of a protein, because amino acid side chains essential for recognition will be buried.	Lysine	177-183	lysine methyltransferase 5A	Homo sapiens	138-142
11186266-0	2000	Hb Clinico-Madrid [alpha90(FG2)Lys-->Arg]: a new hemoglobin mutation in the alpha2-globin gene.	Lysine	31-34	hemoglobin subunit alpha 2	Homo sapiens	76-89
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Lysine	137-143	triggering receptor expressed on myeloid cells 1	Mus musculus	61-67
11027581-3	2000	Mutant CCS in which amino acid residues His147 and Asp167 were substituted by Ala exhibited a decreased ability to complement the growth of SY2950 under Lys-deficient conditions.	Lysine	153-156	copper chaperone for superoxide dismutase	Homo sapiens	7-10
11013299-2	2000	The apolipoprotein [a] (apo[a]) component of Lp[a] confers unique structural properties to this lipoprotein, including the ability to bind to lysine residues in biological substrates.	Lysine	142-148	lipoprotein(a)	Homo sapiens	45-49
17110376-10	2007	These data suggest that acetylation of Lys-39 of C/EBPbeta, alone or in combination with acetylation at other lysines, may play a role in C/EBPbeta-mediated transcriptional activation.	Lysine	39-42	CCAAT enhancer binding protein beta	Homo sapiens	138-147
17110376-10	2007	These data suggest that acetylation of Lys-39 of C/EBPbeta, alone or in combination with acetylation at other lysines, may play a role in C/EBPbeta-mediated transcriptional activation.	Lysine	110-117	CCAAT enhancer binding protein beta	Homo sapiens	138-147
17114793-6	2007	Rab38(CAKS) is not methylated in vivo, presumably because of the inhibitory action of the lysine residue within the AAX motif for cleavage by Rce1.	Lysine	90-96	RAB38, member RAS oncogene family	Homo sapiens	0-5
11013299-3	2000	It has been shown, however, that only a fraction of plasma Lp[a] (Lp[a]-Lys(+)) binds to lysine-Sepharose in vitro.	Lysine	72-75	lipoprotein(a)	Homo sapiens	59-63
22403019-3	2012	This study determined whether Lysine overloading of human proximal tubular cells (HK-2) in culture enhances apoptotic cell loss and its associated mechanisms.	Lysine	30-36	hexokinase 2	Homo sapiens	82-86
11013299-3	2000	It has been shown, however, that only a fraction of plasma Lp[a] (Lp[a]-Lys(+)) binds to lysine-Sepharose in vitro.	Lysine	72-75	lipoprotein(a)	Homo sapiens	66-70
11013299-3	2000	It has been shown, however, that only a fraction of plasma Lp[a] (Lp[a]-Lys(+)) binds to lysine-Sepharose in vitro.	Lysine	89-95	lipoprotein(a)	Homo sapiens	59-63
11013299-3	2000	It has been shown, however, that only a fraction of plasma Lp[a] (Lp[a]-Lys(+)) binds to lysine-Sepharose in vitro.	Lysine	89-95	lipoprotein(a)	Homo sapiens	66-70
22403019-4	2012	Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10 mM) increased apoptosis (+30%; p &lt; 0.01 vs.C), as well as Bax and Apaf-1 expressions (+30-50% p &lt; 0.05), while downregulated Bcl-2 (-40% p &lt; 0.05).	Lysine	22-28	hexokinase 2	Homo sapiens	12-16
11013299-4	2000	The nature of the non-lysine-binding Lp[a] fraction in plasma (Lp[a]-Lys(-)) is currently unknown.	Lysine	22-28	lipoprotein(a)	Homo sapiens	37-41
11013299-4	2000	The nature of the non-lysine-binding Lp[a] fraction in plasma (Lp[a]-Lys(-)) is currently unknown.	Lysine	69-72	lipoprotein(a)	Homo sapiens	37-41
17174094-5	2007	Our results suggest that during the prolonged cold, VRN5 and VIN3 form a heterodimer necessary for establishing the vernalization-induced chromatin modifications, histone deacetylation, and H3 lysine 27 trimethylation required for the epigenetic silencing of FLC.	Lysine	193-199	Fibronectin type III domain-containing protein	Arabidopsis thaliana	52-56
17174094-5	2007	Our results suggest that during the prolonged cold, VRN5 and VIN3 form a heterodimer necessary for establishing the vernalization-induced chromatin modifications, histone deacetylation, and H3 lysine 27 trimethylation required for the epigenetic silencing of FLC.	Lysine	193-199	Fibronectin type III domain-containing protein	Arabidopsis thaliana	61-65
11013299-5	2000	In the present study, the Lp[a]-Lys(+) fraction was determined in the plasma of six unrelated individuals; the Lp[a]-Lys(+) fraction in these plasma samples ranged from approximately 37 to approximately 48%.	Lysine	32-35	lipoprotein(a)	Homo sapiens	26-30
22403019-8	2012	Treating HK-2 with antioxidants, such as Cysteine and its analog, N-acetyl-L-cysteine (NAC), rescued the HK-2 from apoptosis induced by Lysine.	Lysine	136-142	hexokinase 2	Homo sapiens	9-13
11013299-5	2000	In the present study, the Lp[a]-Lys(+) fraction was determined in the plasma of six unrelated individuals; the Lp[a]-Lys(+) fraction in these plasma samples ranged from approximately 37 to approximately 48%.	Lysine	117-120	lipoprotein(a)	Homo sapiens	111-115
11013299-6	2000	Interestingly, purification of the Lp[a] by density gradient ultracentrifugation followed by gel filtration and ion-exchange chromatography resulted in progressive increases in the Lp[a]-Lys(+) fraction.	Lysine	187-190	lipoprotein(a)	Homo sapiens	35-39
22403019-8	2012	Treating HK-2 with antioxidants, such as Cysteine and its analog, N-acetyl-L-cysteine (NAC), rescued the HK-2 from apoptosis induced by Lysine.	Lysine	136-142	hexokinase 2	Homo sapiens	105-109
11013299-6	2000	Interestingly, purification of the Lp[a] by density gradient ultracentrifugation followed by gel filtration and ion-exchange chromatography resulted in progressive increases in the Lp[a]-Lys(+) fraction.	Lysine	187-190	lipoprotein(a)	Homo sapiens	181-185
11013299-9	2000	Taken together, our data suggest that the lysine-binding heterogeneity of plasma Lp[a] is not primarily an intrinsic property of the lipoprotein, but rather results in large part from its ability to noncovalently associate with abundant plasma components such as LDL and fibronectin.	Lysine	42-48	lipoprotein(a)	Homo sapiens	81-85
17336575-2	2007	The SUMO E2 enzyme ubiquitin-conjugating enzyme 9 (Ubc9) is sufficient for substrate recognition and lysine modification of known SUMO targets.	Lysine	101-107	ubiquitin conjugating enzyme E2 I	Homo sapiens	19-49
22964433-2	2012	SUZ12 is a component of the polycomb repressive complex 2 (PRC2) and is essential for PRC2-mediated gene silencing by generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3).	Lysine	147-153	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	0-5
17336575-2	2007	The SUMO E2 enzyme ubiquitin-conjugating enzyme 9 (Ubc9) is sufficient for substrate recognition and lysine modification of known SUMO targets.	Lysine	101-107	ubiquitin conjugating enzyme E2 I	Homo sapiens	51-55
17101795-3	2007	Here, we found that myocardin"s activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation.	Lysine	95-101	small ubiquitin like modifier 1	Homo sapiens	66-72
11013299-10	2000	These interactions appear to mask the lysine-binding site in apo[a] kringle IV type 10, which mediates the interaction of Lp[a] with lysine-Sepharose.	Lysine	38-44	lipoprotein(a)	Homo sapiens	122-126
11013299-10	2000	These interactions appear to mask the lysine-binding site in apo[a] kringle IV type 10, which mediates the interaction of Lp[a] with lysine-Sepharose.	Lysine	133-139	lipoprotein(a)	Homo sapiens	122-126
10945842-2	2000	The aryloxypropanolamines CGP 12177 and LY 362884, originally developed as beta(3)-AR agonists, were found to stimulate the beta(1)-AR.	Lysine	40-42	adrenoceptor beta 1	Homo sapiens	124-134
10945842-3	2000	Interestingly, both CGP 12177 and LY 362884 exhibited an anomalous biphasic effect on beta(1)-AR.	Lysine	34-36	adrenoceptor beta 1	Homo sapiens	86-96
10945842-4	2000	Low concentrations of either CGP 12177 or LY 362884 potently blocked isoproterenol-induced stimulation of beta(1)-AR, whereas higher concentrations of these compounds stimulated the beta(1)-AR.	Lysine	42-44	adrenoceptor beta 1	Homo sapiens	106-116
23230084-3	2012	Recently, we reported that p300 acetylates Skp2 at two conserved lysine residues K68 and K71 within its NLS (Nuclear localization signal).	Lysine	65-71	E1A binding protein p300	Homo sapiens	27-31
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	18-21	SMAD family member 1	Homo sapiens	89-93
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	18-21	SMAD family member 3	Homo sapiens	120-126
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 1	Homo sapiens	89-93
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 3	Homo sapiens	120-126
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 1	Homo sapiens	89-93
17251191-0	2007	SET3p monomethylates histone H3 on lysine 9 and is required for the silencing of tandemly repeated transgenes in Chlamydomonas.	Lysine	35-41	uncharacterized protein	Chlamydomonas reinhardtii	0-5
23230084-3	2012	Recently, we reported that p300 acetylates Skp2 at two conserved lysine residues K68 and K71 within its NLS (Nuclear localization signal).	Lysine	65-71	S-phase kinase associated protein 2	Homo sapiens	43-47
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 3	Homo sapiens	120-126
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 1	Homo sapiens	89-93
17044066-1	2007	A new cross-linked ribonuclease A (RNase A) dimer composed of monomeric units covalently linked by a single amide bond between the side-chains of Lys(66) and Glu(9) is described.	Lysine	146-149	ribonuclease A family member 1, pancreatic	Homo sapiens	19-33
22908229-6	2012	Mechanistically, p300 specifically acetylates HIF1alpha at Lys-709, which increases the protein stability and decreases polyubiquitination in both normoxia and hypoxia.	Lysine	59-62	E1A binding protein p300	Homo sapiens	17-21
17044066-1	2007	A new cross-linked ribonuclease A (RNase A) dimer composed of monomeric units covalently linked by a single amide bond between the side-chains of Lys(66) and Glu(9) is described.	Lysine	146-149	ribonuclease A family member 1, pancreatic	Homo sapiens	35-42
10846168-4	2000	This basic motif (Lys(40-)Lys-Leu-Lys-Lys(44)), conserved among all the pathway-specific Smad proteins, is required for Smad 3 nuclear import in response to ligand.	Lysine	26-29	SMAD family member 3	Homo sapiens	120-126
22908229-10	2012	Taken together, these data demonstrate a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation.	Lysine	152-155	E1A binding protein p300	Homo sapiens	85-89
22908229-10	2012	Taken together, these data demonstrate a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation.	Lysine	152-155	E1A binding protein p300	Homo sapiens	143-147
23062340-1	2012	The proline-, glutamate-, valine-, and lysine-rich (PEVK) domain of the giant muscle protein titin is thought to be an intrinsically unstructured random-coil segment.	Lysine	39-45	titin	Homo sapiens	93-98
11018286-3	2000	In this report we show that macrophage extracts contain a protease which specifically cleaves human MARCKS, expressed in a cell-free system or in E. coli, between Lys-6 and Thr-7.	Lysine	163-166	myristoylated alanine rich protein kinase C substrate	Homo sapiens	100-106
10838076-1	2000	Staphylokinase (SAK) forms an inactive 1:1 complex with plasminogen (PG), which requires both the conversion of PG to plasmin (Pm) to expose an active site in PG-SAK activator complex and the amino-terminal processing of SAK to expose the positively charged (Lys-11) amino-terminus after removal of the 10 N-terminal amino acid residues from the full length protein.	Lysine	259-262	plasminogen	Homo sapiens	56-63
17346225-2	2007	The substitution of Lys residue by Arg at P1 leads to 2-fold increase in the efficiency of enteropeptidase hydrolysis; the absence of the negatively charged residue at P2 reduces the efficiency of such hydrolysis by two orders of magnitude.	Lysine	20-23	transmembrane serine protease 15	Homo sapiens	91-106
17346225-3	2007	The difference in efficiency of peptide chain hydrolysis after Lys/Arg residues by enteropeptidase compared to trypsin is equal to the difference in hydrolysis by serine proteases of different primary specificity of their specific substrates.	Lysine	63-66	transmembrane serine protease 15	Homo sapiens	83-98
17074756-6	2006	Lys(19) in the MH1 domain was identified as the major acetylated residue in both the long and short isoform of Smad2.	Lysine	0-3	SMAD family member 2	Homo sapiens	111-116
17074756-7	2006	Mutation of Lys(19) also reduced the p300-mediated acetylation of Smad3.	Lysine	12-15	E1A binding protein p300	Homo sapiens	37-41
10825373-4	2000	The NK(2) receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK(1) and NK(3) receptor-selective agonists, [Sar(9), Met(O(2))(11)]SP and [N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors.	Lysine	39-42	tachykinin receptor 3	Homo sapiens	161-175
17074756-7	2006	Mutation of Lys(19) also reduced the p300-mediated acetylation of Smad3.	Lysine	12-15	SMAD family member 3	Homo sapiens	66-71
17074756-10	2006	Acetylation of Lys(19) also enhanced the DNA binding activity of Smad3.	Lysine	15-18	SMAD family member 3	Homo sapiens	65-70
22748127-4	2012	Using bioinformatics analysis coupled with in vitro and in vivo Sumoylation assays, we found that lysine (K) 364 of LEDGF was Sumoylated, repressing its transcriptional activity.	Lysine	98-104	PC4 and SFRS1 interacting protein 1	Homo sapiens	116-121
17074756-11	2006	Our data indicate that acetylation of Lys(19) induces a conformational change in the MH1 domain of the short isoform of Smad2, thereby making its DNA binding domain accessible for interactions with DNA.	Lysine	38-41	SMAD family member 2	Homo sapiens	120-125
18726387-7	2000	The ASYIP protein contains a C-terminal endoplasmic reticulum retrieval signal (Lys-Lys-Lys-Ala-Glu).	Lysine	80-83	reticulon 3	Homo sapiens	4-9
18726387-7	2000	The ASYIP protein contains a C-terminal endoplasmic reticulum retrieval signal (Lys-Lys-Lys-Ala-Glu).	Lysine	84-87	reticulon 3	Homo sapiens	4-9
22665484-4	2012	TRPA1 wild type Lys-179 protein expressed in HEK cells exhibited intact biochemical properties, inclusive trafficking into the plasma membrane, formation of large protein complexes, and the ability to be activated by cold.	Lysine	16-19	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
10809722-6	2000	Interestingly, we found that proDelta(260-508)MMP-19 has the tendency to autoactivate, whereby the Lys(97)-Tyr(98) peptide bond is hydrolyzed, resulting in free catalytic domain.	Lysine	99-102	matrix metallopeptidase 19	Homo sapiens	29-52
17176067-4	2006	Using protein surface modification and mass spectrometry, we identify numerous lysine residues that are exposed to solvent in monomeric MLH1.	Lysine	79-85	mismatch repair ATPase MLH1	Saccharomyces cerevisiae S288C	136-140
22665484-6	2012	In contrast, HEK cells expressing the variant Lys-179 TRPA1 failed to get activated by cold possibly due to the loss of ability to interact with other proteins or other TRPA1 monomers during oligomerization.	Lysine	46-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	54-59
17183676-3	2006	METHODS AND FINDINGS: Here, we show that the expression level of Hoxa9 is correlated with the location of increased trimethylated histone 3 lysine 4 (H3K4M3).	Lysine	140-146	homeobox A9	Homo sapiens	65-70
22665484-6	2012	In contrast, HEK cells expressing the variant Lys-179 TRPA1 failed to get activated by cold possibly due to the loss of ability to interact with other proteins or other TRPA1 monomers during oligomerization.	Lysine	46-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	169-174
22700985-4	2012	Additionally and notably, we report the first instance of direct identification by mass spectrometry of a site of small ubiquitin-like modifier (SUMO) adduction, Lys-679 of Bcl11b, in a protein isolated from a native, mammalian cell.	Lysine	162-165	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	173-179
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Lysine	140-146	Rev	Human immunodeficiency virus 1	66-69
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Lysine	140-146	Rev	Human immunodeficiency virus 1	168-171
10799544-4	2000	Stoichiometric binding of SK to native Pm was followed by generation of a two-fragment form of SK cleaved at Lys(59) (SK"), which exhibited an indistinguishable affinity for labeled Pm, while a truncated, SK(55-414) species had a 120-360-fold reduced affinity.	Lysine	109-112	plasminogen	Homo sapiens	182-184
22924173-5	2012	The addition of lysine, threonine and methionine in Diet LTM increased the expression of b(0,+) in jejunum and CAT-1 in the Semitendinosus and Longissiums muscles and decreased CAT-1 in jejunum; the serum concentration of lysine was also increased (p &lt; 0.01).	Lysine	16-22	solute carrier family 7 member 1	Sus scrofa	111-116
10788439-4	2000	In contrast to ubiquitin, SUMO-1 preferentially targets a single lysine residue in c-Jun (Lys-229), and the abrogation of SUMO-1 modification does not compromise its ubiquitination.	Lysine	65-71	small ubiquitin like modifier 1	Homo sapiens	26-32
10788439-4	2000	In contrast to ubiquitin, SUMO-1 preferentially targets a single lysine residue in c-Jun (Lys-229), and the abrogation of SUMO-1 modification does not compromise its ubiquitination.	Lysine	90-93	small ubiquitin like modifier 1	Homo sapiens	26-32
10821654-4	2000	The present studies describe the synthesis of an Abeta(1)(-)(40) analogue that contains a biotin at the amino terminus and a diethylenetriaminepentaacetic acid (DTPA) moiety conjugated to one of the internal lysine residues.	Lysine	208-214	AA1	Homo sapiens	49-57
17130289-2	2006	In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3) yRad18 promotes translesion synthesis (TLS), whereas the lysine-63-linked polyubiquitination of PCNA by yRad5 (E3) promotes the error-free mode of bypass.	Lysine	120-126	DNA helicase RAD5	Saccharomyces cerevisiae S288C	167-172
22924173-5	2012	The addition of lysine, threonine and methionine in Diet LTM increased the expression of b(0,+) in jejunum and CAT-1 in the Semitendinosus and Longissiums muscles and decreased CAT-1 in jejunum; the serum concentration of lysine was also increased (p &lt; 0.01).	Lysine	16-22	solute carrier family 7 member 1	Sus scrofa	177-182
16963503-4	2006	Here, we determined the effect of H142 replacement by lysine, alanine, and glutamate on the voltage gating of Cx43 channels.	Lysine	54-60	gap junction protein alpha 1	Homo sapiens	110-114
22745309-3	2012	The data suggest that the loss of faf reduces the activity of Medea (a homolog of Smad4) below the minimum necessary for adequate Dpp signaling and that this is likely due to excessive ubiquitylation on a specific lysine.	Lysine	214-220	SMAD family member 4	Homo sapiens	82-87
10736562-1	2000	MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence.	Lysine	211-218	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
10736562-1	2000	MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence.	Lysine	211-218	myristoylated alanine rich protein kinase C substrate	Homo sapiens	8-53
17049505-7	2006	l-Lysine was found to exert its effect through the NF-kappaB pathway by inhibiting the p65 subunit specifically.	Lysine	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-90
22547391-5	2012	PCAF associates with p27 through its catalytic domain and acetylates p27 at lysine 100.	Lysine	76-82	lysine acetyltransferase 2B	Homo sapiens	0-4
17049505-8	2006	Also l-lysine caused a decrease in the levels MMP-2 and MMP-9 as well as their enzymatic activity.	Lysine	5-13	matrix metallopeptidase 2	Homo sapiens	46-51
10790154-14	2000	A lysine residue in the N terminus of Kir4.1 is critical.	Lysine	2-8	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	38-44
22713458-0	2012	Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers.	Lysine	24-30	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	43-79
10713046-6	2000	A murine PTTG cDNA that encodes a variant C-terminal tail (Gly-Lys-Gly-Val-Arg-Ser-Asn-Gly-Cys-Lys-Asp-Leu-Val-Thr) was cloned.	Lysine	63-66	pituitary tumor-transforming gene 1	Mus musculus	9-13
16980404-5	2006	All examined SHMT contain an 8-amino-acid conserved sequence, VTTTTHKT, containing the active-site lysyl residue (Lys 251 in TvSHMT) that forms an internal aldimine with PLP.	Lysine	114-117	pyridoxal phosphatase	Homo sapiens	170-173
17012228-9	2006	Site-directed mutagenesis studies showed that Lys-386 of p53, the SUMO-1 modification site, is also the modification site for SUMO-2/3.	Lysine	46-49	small ubiquitin like modifier 1	Homo sapiens	66-72
16926151-6	2006	Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity as measured by an increased acetylation of RelA/p65 at Lys(310), a modification that is required for full NF-kappaB transcription.	Lysine	146-149	E1A binding protein p300	Homo sapiens	32-36
16926151-6	2006	Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity as measured by an increased acetylation of RelA/p65 at Lys(310), a modification that is required for full NF-kappaB transcription.	Lysine	146-149	RELA proto-oncogene, NF-kB subunit	Homo sapiens	134-138
10704226-0	2000	The relationship between the effect of lysine analogues and salt on the conformation of lipoprotein(a).	Lysine	39-45	lipoprotein(a)	Homo sapiens	88-102
22713458-0	2012	Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers.	Lysine	24-30	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	81-85
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	ring finger protein 168	Homo sapiens	59-65
22508312-1	2012	Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes.	Lysine	62-69	PBANKA_082650	Plasmodium berghei ANKA	0-19
10794173-1	2000	The Ubc13 protein was recently identified for its unique role in ubiquitin (Ub) chain assembly at the Ub Lys-63 residue instead of the conventional Lys-48 residue.	Lysine	105-108	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	4-9
10794173-1	2000	The Ubc13 protein was recently identified for its unique role in ubiquitin (Ub) chain assembly at the Ub Lys-63 residue instead of the conventional Lys-48 residue.	Lysine	105-108	ubiquitin	Saccharomyces cerevisiae S288C	65-74
10794173-1	2000	The Ubc13 protein was recently identified for its unique role in ubiquitin (Ub) chain assembly at the Ub Lys-63 residue instead of the conventional Lys-48 residue.	Lysine	148-151	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	4-9
16926151-6	2006	Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity as measured by an increased acetylation of RelA/p65 at Lys(310), a modification that is required for full NF-kappaB transcription.	Lysine	146-149	RELA proto-oncogene, NF-kB subunit	Homo sapiens	139-142
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	E1A binding protein p300	Homo sapiens	42-46
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	RELA proto-oncogene, NF-kB subunit	Homo sapiens	206-210
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	RELA proto-oncogene, NF-kB subunit	Homo sapiens	211-214
16912044-3	2006	RXRalpha was modified by SUMO-1 in vivo as well as in vitro, and the Lys-108 residue within the IKPP sequence of RXRalpha AF-1 domain was identified as the major SUMO-1 acceptor site.	Lysine	69-72	small ubiquitin like modifier 1	Homo sapiens	162-168
10631010-5	2000	The 24k-endopeptidase specifically hydrolyzed the Ser(441)-Val(442) peptide bond in human plasmin(ogen), with additional cleavage of the Lys(78)-Val(79) and Pro(447)-Val(448) peptide bonds, and a secondary cleavage at Lys(615)-Val(616).	Lysine	218-221	plasminogen	Homo sapiens	90-97
22508312-1	2012	Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes.	Lysine	62-69	PBANKA_082650	Plasmodium berghei ANKA	21-25
22503989-2	2012	In this study, tetrameric canine uricase variant was modified by covalent conjugation of all accessible e amino sites of lysine residues with a smaller 5kDa mPEG (mPEG-UHC).	Lysine	121-127	urate oxidase	Canis lupus familiaris	33-40
10625554-7	2000	The mutant Hd protein (HOXA13(Hd)) consists of the first 25 amino acids of wild-type HOXA13 sequence, followed by 275 amino acids of arginine- and lysine-rich, novel sequence, and lacks the homeodomain.	Lysine	147-153	homeobox A13	Mus musculus	23-29
10625480-8	2000	We speculate that a reaction between a carbonyl on one actin polymer subunit and a lysine on a neighboring subunit is responsible for ANF formation.	Lysine	83-89	actin epsilon 1	Bos taurus	55-60
16643891-3	2006	We earlier reported that angiostatin binds to cell surface annexin II through the lysine-binding domain (kringles 1-4) [Tuszynski, G.P., Sharma, M., Rothman, V.L., Sharma, M.C., 2002.	Lysine	82-88	plasminogen	Mus musculus	25-36
16643891-4	2006	Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells.	Lysine	70-76	plasminogen	Mus musculus	0-11
16643891-11	2006	Angiostatin also reduced plasmin generation by 81.6%, suggesting that angiostatin may be competing with plasminogen through lysine-binding domain.	Lysine	124-130	plasminogen	Mus musculus	0-11
16643891-11	2006	Angiostatin also reduced plasmin generation by 81.6%, suggesting that angiostatin may be competing with plasminogen through lysine-binding domain.	Lysine	124-130	plasminogen	Mus musculus	70-81
22389112-5	2012	Our results indicate that claudin 5 has a relatively short half-life and can be polyubiquitinated on lysine 199.	Lysine	101-107	claudin 5	Homo sapiens	26-35
16814543-2	2006	Chimera peptides with long spacers (a Lys and five or eight Gly residues) showed synergistically improved affinity for both the mu-opioid receptor and ORL1 receptor, while the chimera peptides with short spacers (Lys residue only) showed decreased or similar affinity compared to the monomeric receptor ligands.	Lysine	38-41	opioid related nociceptin receptor 1	Homo sapiens	151-155
10618426-4	2000	Analysis of individual histone H4 lysines demonstrate that chromatin domain opening is coincident with rapid acetylation of histone H4 K5, K12, and K16 and that maintenance of the open domain is correlated with acetylation of histone H4 K8.	Lysine	34-41	keratin 16	Homo sapiens	148-151
16946709-4	2006	We also demonstrate that acetylation of lysine 320 (K320) of p53 is specifically involved in the promotion of neurite outgrowth and in the regulation of the expression of Coronin 1b and Rab13.	Lysine	40-46	coronin, actin binding protein 1B	Mus musculus	171-181
11450502-6	2000	Phosphotyrosine immunoblotting revealed that apparent insulin receptor autophosphorylation was visible only with IgG-NOV, not with the IgG-JAN or -FEB. Mutation of tyrosine-960 or lysine-1018 of the insulin receptor failed to transduce the IgG"s stimulatory effect.	Lysine	180-186	insulin receptor	Homo sapiens	54-70
22261743-4	2012	By employing serine-to-alanine mutants, we found that hypo-phosphorylated nuclear RelA is monoubiquitinated on multiple lysine residues.	Lysine	120-126	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-86
11012092-8	2000	Taken together, these data suggest that apo(a) binds to fibrin with poor affinity (low microM) and that the total concentration of apo(a) binding sites available on modified-fibrinogen surfaces is affected by both apo(a) isoform size and by the increased availability of C-terminal lysines on plasmin-degraded fibrinogen surfaces.	Lysine	282-289	lipoprotein(a)	Homo sapiens	131-137
11012092-8	2000	Taken together, these data suggest that apo(a) binds to fibrin with poor affinity (low microM) and that the total concentration of apo(a) binding sites available on modified-fibrinogen surfaces is affected by both apo(a) isoform size and by the increased availability of C-terminal lysines on plasmin-degraded fibrinogen surfaces.	Lysine	282-289	lipoprotein(a)	Homo sapiens	131-137
22556266-6	2012	Moreover, we provide experimental evidence indicating that PIN2 vacuolar sorting depends on modification specifically by lysine(63)-linked ubiquitin chains.	Lysine	121-127	Auxin efflux carrier family protein	Arabidopsis thaliana	59-63
16733732-0	2006	Novel lysine biosynthetic gene sequences (LYS1 and LYS5) used as PCR targets for the detection of the pathogenic Candida yeast.	Lysine	6-12	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	51-55
22452443-1	2012	The purpose of this study was to examine whether the structural modification on the positively charged Lys linker could reduce the kidney uptake of (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Lysine	103-106	pro-opiomelanocortin-alpha	Mus musculus	193-229
11315093-7	2000	Significant activation of FAK was demonstrated when cells adhered to fibronectin, as compared to poly-L-lysine, thus demonstrating that beta-1-integrin plays a significant role in activating FAK.	Lysine	97-110	protein tyrosine kinase 2	Homo sapiens	26-29
16899520-1	2006	WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]).	Lysine	106-112	WNK lysine deficient protein kinase 1	Mus musculus	0-4
10594033-4	2000	We have partially purified a complex containing MSL1, -2, and -3, MOF, MLE, and roX2 RNA and demonstrated that it exclusively acetylates H4 at lysine 16 on nucleosomal substrates.	Lysine	143-149	long non-coding RNA on the X 2	Drosophila melanogaster	80-84
22452443-1	2012	The purpose of this study was to examine whether the structural modification on the positively charged Lys linker could reduce the kidney uptake of (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Lysine	103-106	pro-opiomelanocortin-alpha	Mus musculus	231-240
16899520-1	2006	WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]).	Lysine	106-112	WNK lysine deficient protein kinase 4	Mus musculus	9-13
16899520-1	2006	WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]).	Lysine	129-135	WNK lysine deficient protein kinase 1	Mus musculus	0-4
22301686-1	2012	AIMS: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver.	Lysine	115-121	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	267-272
16899520-1	2006	WNK1 and WNK4 are unusual serine/threonine kinases with atypical positioning of the catalytic active-site lysine (WNK: With-No-K[lysine]).	Lysine	129-135	WNK lysine deficient protein kinase 4	Mus musculus	9-13
10608874-7	1999	Cytochrome c/cytochrome c oxidase interactions of Lys(13) with Asp(119) and Lys(72) with Gln(103) and Asp(158) are the most critical polar interactions due to their proximity to the hydrophobic region and exclusion from bulk solvent.	Lysine	50-53	LOC104968582	Bos taurus	0-12
10608874-7	1999	Cytochrome c/cytochrome c oxidase interactions of Lys(13) with Asp(119) and Lys(72) with Gln(103) and Asp(158) are the most critical polar interactions due to their proximity to the hydrophobic region and exclusion from bulk solvent.	Lysine	50-53	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	13-33
10637513-6	1999	In contrast, integrin-linked kinase mutated in a lysine residue critical for function in protein kinases is inactive in these experiments, and furthermore, acts dominantly to block serine-473 phosphorylation induced by ErbB4.	Lysine	49-55	erb-b2 receptor tyrosine kinase 4	Homo sapiens	219-224
16760361-2	2006	Mutagenesis of lysine at position 324 in helix 6 of the wild-type (WT) human beta1-adrenergic receptor (beta1-AR) generated mutant receptors that had GTP-insensitive single low-affinity binding sites for agonists and reduced potencies of full or partial agonists in stimulating adenylyl cyclase.	Lysine	15-21	adrenoceptor beta 1	Homo sapiens	77-102
22207202-0	2012	Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.	Lysine	56-62	transcription factor 3	Homo sapiens	29-32
16760361-2	2006	Mutagenesis of lysine at position 324 in helix 6 of the wild-type (WT) human beta1-adrenergic receptor (beta1-AR) generated mutant receptors that had GTP-insensitive single low-affinity binding sites for agonists and reduced potencies of full or partial agonists in stimulating adenylyl cyclase.	Lysine	15-21	adrenoceptor beta 1	Homo sapiens	104-112
10606511-4	1999	It reveals that residues Gln-14, His-15, Lys-38, Thr-42, and His-128 at the active site are conserved as in all other RNase A homologues.	Lysine	41-44	ribonuclease A family member 1, pancreatic	Homo sapiens	118-125
22207202-7	2012	Here, we use mutagenesis to show that a lysine residue at position 34 within AD1 of E12/E47 is acetylated by CBP/p300 and PCAF.	Lysine	40-46	lysine acetyltransferase 2B	Homo sapiens	122-126
16828461-8	2006	These findings imply that SUMO-1 modification on lysine 75 may participate in regulating SOD1 stability and its aggregation process.	Lysine	49-55	small ubiquitin like modifier 1	Homo sapiens	26-32
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Lysine	132-135	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
16735510-4	2006	Multiple lysine residues, located within the tyrosine kinase domain of EGFR, serve as attachment sites for Nedd8.	Lysine	9-15	NEDD8 ubiquitin like modifier	Homo sapiens	107-112
10611379-0	1999	pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.	Lysine	57-60	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	13-17
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Lysine	132-135	homeobox A3	Homo sapiens	50-55
10611379-3	1999	Here we show that a lysine residue close to TM1, identified previously as a structural element required for pH-induced gating, is protonated at neutral pH and that this protonation drives pH gating in ROMK and other K(ir) channels.	Lysine	20-26	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	201-205
22808515-3	2012	The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts.	Lysine	243-246	C-X-C motif chemokine ligand 12	Homo sapiens	42-48
22102315-3	2012	Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk for alcohol dependence (AD).	Lysine	47-50	aldehyde dehydrogenase 2 family member	Homo sapiens	133-138
10607407-0	1999	Identification of lysine residue involved in inactivation of brain glutamate dehydrogenase isoproteins by o-phthalaldehyde.	Lysine	18-24	glutamate dehydrogenase 1, mitochondrial	Bos taurus	67-90
16820411-9	2006	In a mutant cell line, Paju-ICAM-5-KK/AA, the distribution was altered, which implies the importance of the lysines in the interaction.	Lysine	108-115	intercellular adhesion molecule 5	Homo sapiens	28-34
22427655-0	2012	Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.	Lysine	116-122	leucine-rich repeats and WD repeat domain containing 1	Mus musculus	0-54
10585940-3	1999	Titin"s force arises from its extensible I-band region, which consists of two main segment types: serially linked immunoglobulin-like domains (tandem Ig segments) interrupted with a proline (P)-, glutamate (E)-, valine (V)-, and lysine (K)-rich segment called PEVK segment.	Lysine	229-235	titin	Homo sapiens	0-5
10625440-1	1999	The kringle 2 (K2) module of human plasminogen (Pgn) binds L-lysine and analogous zwitterionic compounds, such as the antifibronolytic agent trans-(aminomethyl)cyclohexanecarboxylic acid (AMCHA).	Lysine	59-67	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	48-51
10625440-14	1999	Consistent with the preference of K2 for binding 5-aminopentanoic acid over 6-aminohexanoic acid, the positions of the ionic centers within the K2 binding site approach each other approximately 1A closer relative to what is observed in lysine binding sites of homologous Pgn modules.	Lysine	236-242	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	271-274
16871210-1	2006	Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome.	Lysine	60-66	small nucleolar RNA, C/D box 34	Homo sapiens	41-44
22427655-2	2012	Lrwd1 and ORC are known to co-purify with repressive histone marks (trimethylated lysine 9 of histone H3 (H3K9me3) and trimethylated lysine 20 of histone H4 (H4K20me3)) and localize to pericentric heterochromatin.	Lysine	82-88	leucine-rich repeats and WD repeat domain containing 1	Mus musculus	0-5
10625471-0	1999	A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inhibitory factor.	Lysine	58-64	macrophage migration inhibitory factor	Homo sapiens	75-101
22427655-2	2012	Lrwd1 and ORC are known to co-purify with repressive histone marks (trimethylated lysine 9 of histone H3 (H3K9me3) and trimethylated lysine 20 of histone H4 (H4K20me3)) and localize to pericentric heterochromatin.	Lysine	133-139	leucine-rich repeats and WD repeat domain containing 1	Mus musculus	0-5
10625471-0	1999	A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inhibitory factor.	Lysine	58-64	macrophage migration inhibitory factor	Homo sapiens	135-162
10625471-12	1999	The combination of these results indicates that the primary function of Lys-32 in the PPT activity of MIF is to lower the pK(a) of Pro-1.	Lysine	72-75	macrophage migration inhibitory factor	Homo sapiens	86-89
16705060-6	2006	TNF-alpha treatment decreased ATGL transcript in a time-dependent manner that paralleled TNF-alpha downregulation of PPARgamma with a maximal decrease noted by 6 h. TNF-alpha effects on ATGL were attenuated by pretreatment with PD-98059, LY-294002, or rapamycin, suggesting involvement of the p44/42 MAP kinase, PI 3-kinase, and p70 ribosomal protein S6 kinase signals.	Lysine	238-240	peroxisome proliferator activated receptor gamma	Mus musculus	117-126
22483804-2	2012	In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1-MLL4) whose specific functions are largely unknown.	Lysine	30-36	lysine methyltransferase 2B	Homo sapiens	180-184
16906410-2	2006	Hyperornithinaemia is accompanied by lysinuria and reduced lysine plasma levels in GA.	Lysine	59-65	ornithine aminotransferase	Homo sapiens	83-85
10625471-12	1999	The combination of these results indicates that the primary function of Lys-32 in the PPT activity of MIF is to lower the pK(a) of Pro-1.	Lysine	72-75	macrophage migration inhibitory factor	Homo sapiens	102-105
10558899-2	1999	The rat ATX1 homologue protein (Rah1p), which shows 35%, 38%, and 89% identities with Atx1p, CUC-1, and HAH1, respectively, conserves both the MTCXXC copper-binding site in the N terminus and the KTGK lysine-rich region in the C terminus.	Lysine	201-207	antioxidant 1 copper chaperone	Rattus norvegicus	8-12
22182520-0	2012	A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.	Lysine	85-91	Polycomb	Drosophila melanogaster	140-148
10585777-4	1999	We cloned canine Atox1, which shows conserved motifs of the copper-binding domain (MTCXXC) and of the lysine-rich region (KTGK), and showed 88, 80, and 41% amino acid sequence identity with the orthologous mouse, human, and yeast proteins.	Lysine	102-108	antioxidant 1 copper chaperone	Canis lupus familiaris	17-22
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Lysine	144-147	furin, paired basic amino acid cleaving enzyme	Homo sapiens	249-254
16648821-4	2006	Point mutagenesis indicated that Lys 730, located in the second nuclear localization signal, is the main target of p300 activity.	Lysine	33-36	E1A binding protein p300	Homo sapiens	115-119
22182520-1	2012	Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing.	Lysine	53-59	Polycomb	Drosophila melanogaster	11-19
16759229-7	2006	Taken together, the results indicate that mesotrypsin is not a defective protease on polypeptide substrates in general, but exhibits a relatively high specificity for Lys/Arg-Ser/Thr peptide bonds.	Lysine	167-170	serine protease 3	Homo sapiens	42-53
22419068-0	2012	Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.	Lysine	64-70	SET and MYND domain containing 3	Homo sapiens	0-5
16897183-4	2006	Site-directed mutagenesis showed that Ile(275), Lys(276) and Arg(277) in the C-terminus of PSTD in ST8Sia IV, which is contiguous with the N-terminus of sialylmotif-S, were essential for polysialylation.	Lysine	48-51	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	99-108
10491201-7	1999	Replacement of the His6 residue of alpha-MSH-ND by Gln, Asn, Arg or Lys decreased not only the receptor binding, but also the cAMP-generating activity in both the MC3R and the MC4R.	Lysine	68-71	melanocortin receptor 4	Cricetulus griseus	176-180
22419068-2	2012	Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me).	Lysine	60-66	SET and MYND domain containing 3	Homo sapiens	18-23
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Lysine	127-130	zona pellucida glycoprotein 2	Mus musculus	68-72
22790203-3	2012	cIAP1 and XIAP directly conjugate polyubiquitin chains to Lysine 147 of activated Rac1 and target it for proteasomal degradation.	Lysine	58-64	baculoviral IAP repeat containing 2	Homo sapiens	0-5
10556557-9	1999	The results of the present study also indicate that chemical modification of Lys(338) of bovine adrenocortical P450scc does not dramatically alter the activity of the heme protein, but does result in a decrease of protein stability.	Lysine	77-80	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	111-118
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	nuclear receptor subfamily 1 group H member 4	Homo sapiens	168-171
22300764-6	2012	It acts downstream of tax-6 in regulation of locomotion and egg-laying after starvation, ASH sensory neuron adaptation and lysine chemotaxis, that is known to be mediated by ASK neurons.	Lysine	123-129	Serine/threonine-protein phosphatase 2B catalytic subunit	Caenorhabditis elegans	22-27
16775314-9	2006	These results indicate that ubiquitination of lysine residues in Gag in the vicinity of the viral late domain is important for HIV-1 budding, while no specific lysine residue may be needed and individual domains can functionally substitute.	Lysine	46-52	Pr55(Gag)	Human immunodeficiency virus 1	65-68
16775314-9	2006	These results indicate that ubiquitination of lysine residues in Gag in the vicinity of the viral late domain is important for HIV-1 budding, while no specific lysine residue may be needed and individual domains can functionally substitute.	Lysine	160-166	Pr55(Gag)	Human immunodeficiency virus 1	65-68
10455016-0	1999	Lysine mutagenesis identifies cationic charges of human CYP17 that interact with cytochrome b5 to promote male sex-hormone biosynthesis.	Lysine	0-6	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	56-61
24213313-6	2012	We have developed strategies to strengthen the ECM collagen and inhibit MMPs through micronutrients such as lysine, proline and ascorbic acid.	Lysine	108-114	matrix metallopeptidase 2	Homo sapiens	72-76
10465743-5	1999	We simulated the effect of AFM tip extension on a hypothetical titin molecule comprised of 30 globular domains (Ig or FNIII) and 25% Pro-Glu-Val-Lys (PEVK) content, and analyzed the unfolding and refolding processes as a function of AFM tip extension, extension rate, and variation in PEVK content.	Lysine	145-148	titin	Homo sapiens	63-68
16787052-0	2006	Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta.	Lysine	17-23	DNA polymerase beta	Homo sapiens	90-102
22235122-6	2012	We found that the C-terminal 16-amino acid fragment of Rad27, a highly polybasic region due to the presence of multiple positively charged lysine and arginine residues, was sufficient and necessary for the stimulation of both Rad27 and Dna2.	Lysine	139-145	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	236-240
16778081-4	2006	AGL19 chromatin is strongly enriched in trimethylation of Lys 27 on histone H3 (H3K27me3) but not in H3K9me2.	Lysine	58-61	AGAMOUS-like 19	Arabidopsis thaliana	0-5
22415824-5	2012	We purify SUMOylated TDP1 from mammalian cells and identify the SUMOylation site as lysine 111.	Lysine	84-90	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	21-25
16601116-2	2006	In the endoplasmic reticulum (ER), profurin folds under the guidance of its prodomain and undergoes an autoproteolytic excision at the consensus furin site Arg-Thr-Lys-Arg107/ generating an enzymatically masked furin-propeptide complex competent for transport to late secretory compartments.	Lysine	164-167	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	51-57	eukaryotic elongation factor 2 kinase	Homo sapiens	210-216
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	51-57	eukaryotic elongation factor 2 kinase	Homo sapiens	299-305
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	145-151	eukaryotic elongation factor 2 kinase	Homo sapiens	210-216
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	145-151	eukaryotic elongation factor 2 kinase	Homo sapiens	299-305
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	145-151	eukaryotic elongation factor 2 kinase	Homo sapiens	210-216
10471776-2	1999	Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, showing that such a lysine residue is not important in eEF-2K activity.	Lysine	145-151	eukaryotic elongation factor 2 kinase	Homo sapiens	299-305
22267734-1	2012	The cellular levels of beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid beta-peptide (Abeta), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.	Lysine	217-223	N-acetyltransferase 8B (putative, gene/pseudogene)	Homo sapiens	244-250
24459728-1	2012	Histone acetyltransferase 1 (HAT1) is an enzyme that is likely to be responsible for the acetylation that occurs on lysines 5 and 12 of the NH2-terminal tail of newly synthesized histone H4.	Lysine	116-123	histone acetyltransferase 1	Homo sapiens	0-27
10457259-10	1999	The data suggests that PLOD2 expression is associated with lysine hydroxylation in the nontriple helical domains of collagen and, thus, could be partially responsible for the tissue-specific collagen cross-linking pattern.	Lysine	59-65	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	23-28
10435998-11	1999	The net effect of increasing open state stability, either by PIP(2) or mutagenesis, is an apparent "uncoupling" of the Kir6.2 subunit from the regulatory input of SUR1, an action that can be partially reversed by screening negative charges on the membrane with poly-L-lysine.	Lysine	261-274	ATP binding cassette subfamily C member 8	Homo sapiens	163-167
16699007-10	2006	These findings support the role of LANA as a transcriptional repressor of lytic reactivation and provide evidence that lysine acetylation regulates LANA interactions with chromatin, Sp1, and ORF50 promoter DNA.	Lysine	119-125	LANA	Human gammaherpesvirus 8	148-152
16534556-6	2006	As the second subject, we found that PPARgamma2 is conjugated with small ubiquitin-related modifier (SUMO) at a specific lysine residue in the amino-terminal region.	Lysine	121-127	peroxisome proliferator activated receptor gamma	Mus musculus	37-47
24459728-1	2012	Histone acetyltransferase 1 (HAT1) is an enzyme that is likely to be responsible for the acetylation that occurs on lysines 5 and 12 of the NH2-terminal tail of newly synthesized histone H4.	Lysine	116-123	histone acetyltransferase 1	Homo sapiens	29-33
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	76-79	GATA zinc finger domain containing 2B	Homo sapiens	18-25
10444079-3	1999	The substitution of a lysine near the C terminus of calnexin with a glutamic acid residue ensured progression through the secretory system rather than retention in or return to the endoplasmic reticulum.	Lysine	22-28	calnexin	Saccharomyces cerevisiae S288C	52-60
22297112-5	2012	The substitution of Gly with Ala significantly enhanced the melanoma uptake of (99m)Tc-RAD-Lys-(Arg(11))CCMSH compared to (99m)Tc-RGD-Lys-(Arg(11))CCMSH in B16/F1 melanoma-bearing C57 mice, providing a new insight into the design of alpha-MSH peptides for melanoma targeting.	Lysine	91-94	pro-opiomelanocortin-alpha	Mus musculus	233-242
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Lysine	108-114	arginase 1	Rattus norvegicus	231-236
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	87-90	GATA zinc finger domain containing 2B	Homo sapiens	18-25
16738318-3	2006	Both p66alpha and p66beta are SUMO-modified in vivo: p66alpha at two sites (Lys-30 and Lys-487) and p66beta at one site (Lys-33).	Lysine	87-90	GATA zinc finger domain containing 2B	Homo sapiens	18-25
16871767-6	2006	Neddylation is the process that conjugates the ubiquitin-like polypeptide Nedd8 to the conserved lysines of cullins.	Lysine	97-104	NEDD8 ubiquitin like modifier	Homo sapiens	74-79
21706061-4	2012	Through mass spectrometry analysis of ubiquitinated RelA, we identified seven lysines that were attached to degradative and non-degradative forms of polyubiquitin.	Lysine	78-85	RELA proto-oncogene, NF-kB subunit	Homo sapiens	52-56
16713561-2	2006	The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation.	Lysine	52-58	CYLD lysine 63 deubiquitinase	Mus musculus	4-8
10442769-4	1999	In order to stabilize the helical structures, we have recently synthesized and studied the PTHrP(1-34) analog [(Lys13-Asp17, Lys26-Asp30)]PTHrP(1-34)NH2, which contains lactam-constrained Lys-Asp side chains at positions i, i+4.	Lysine	112-115	parathyroid hormone like hormone	Homo sapiens	91-96
21518269-3	2012	An unusual mechanism of TRPA1 activation was recently elucidated in which reactive agonists bind covalently to cysteines and lysine in the intracellular N-terminus.	Lysine	125-131	transient receptor potential cation channel subfamily A member 1	Homo sapiens	24-29
10442769-4	1999	In order to stabilize the helical structures, we have recently synthesized and studied the PTHrP(1-34) analog [(Lys13-Asp17, Lys26-Asp30)]PTHrP(1-34)NH2, which contains lactam-constrained Lys-Asp side chains at positions i, i+4.	Lysine	112-115	parathyroid hormone like hormone	Homo sapiens	138-143
16424386-2	2006	We found that cytoplasmic ubiquitylation of Tax C-terminal lysines is critical for Tax binding to the IkappaB kinase complex and subsequent nuclear translocation of RelA.	Lysine	59-66	RELA proto-oncogene, NF-kB subunit	Homo sapiens	165-169
16424386-3	2006	Conversely, we demonstrate that the same lysines are sumoylated in the nucleus, an event required for the formation of RelA/p300-enriched Tax nuclear bodies and full NF-kappaB transcriptional activation.	Lysine	41-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	119-123
10456457-0	1999	Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor.	Lysine	15-18	serpin family A member 5	Homo sapiens	120-139
22053081-7	2012	Chromatin immunoprecipitation (ChIP) analysis revealed that Ago1 was selectively associated with the Ccnb1 promoter and miR-744 increased enrichment of RNA polymerase II (RNAP II) and trimethylation of histone 3 at lysine 4 (H3K4me3) at the Ccnb1 transcription start site.	Lysine	215-221	argonaute RISC catalytic subunit 1	Mus musculus	60-64
10456457-0	1999	Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor.	Lysine	31-34	serpin family A member 5	Homo sapiens	120-139
16520378-1	2006	UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys-48- and Lys-63-linked polyubiquitin to lower denomination forms in vitro.	Lysine	126-129	ubiquitin specific peptidase 8	Homo sapiens	0-4
22053081-7	2012	Chromatin immunoprecipitation (ChIP) analysis revealed that Ago1 was selectively associated with the Ccnb1 promoter and miR-744 increased enrichment of RNA polymerase II (RNAP II) and trimethylation of histone 3 at lysine 4 (H3K4me3) at the Ccnb1 transcription start site.	Lysine	215-221	cyclin B1	Mus musculus	101-106
16520378-1	2006	UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys-48- and Lys-63-linked polyubiquitin to lower denomination forms in vitro.	Lysine	138-141	ubiquitin specific peptidase 8	Homo sapiens	0-4
22649771-1	2011	Small ubiquitin-like modifier-1/2/3 (SUMO-1/2/3) and ubiquitin share similar structure and utilize analogous machinery for protein lysine conjugation.	Lysine	131-137	small ubiquitin like modifier 1	Homo sapiens	0-35
16496168-2	2006	Of the several inherited hemoglobin disorders, hemoglobin E (HbE) (beta 26, GAG-AAG, Glu-Lys) is the most common hemoglobinopathy in Thailand.	Lysine	89-92	hemoglobin subunit epsilon 1	Homo sapiens	47-59
16496168-2	2006	Of the several inherited hemoglobin disorders, hemoglobin E (HbE) (beta 26, GAG-AAG, Glu-Lys) is the most common hemoglobinopathy in Thailand.	Lysine	89-92	hemoglobin subunit epsilon 1	Homo sapiens	61-64
10430036-4	1999	We show here that MASH-1 can be converted into a protein capable of inducing myogenesis in fibroblasts by replacing leucine (130) of MASH-1 with lysine and introducing an additional turn into its basic recognition helix.	Lysine	145-151	achaete-scute family bHLH transcription factor 1	Homo sapiens	18-24
10351989-2	1999	The active form, carboxypeptidase U (CPU; EC 3.4.17.20), retards the rate of fibrinolysis through its ability to cleave C-terminal lysine residues on fibrin partially degraded by plasmin.	Lysine	131-137	carboxypeptidase B2	Homo sapiens	17-35
10351989-2	1999	The active form, carboxypeptidase U (CPU; EC 3.4.17.20), retards the rate of fibrinolysis through its ability to cleave C-terminal lysine residues on fibrin partially degraded by plasmin.	Lysine	131-137	carboxypeptidase B2	Homo sapiens	37-40
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
22649771-1	2011	Small ubiquitin-like modifier-1/2/3 (SUMO-1/2/3) and ubiquitin share similar structure and utilize analogous machinery for protein lysine conjugation.	Lysine	131-137	small ubiquitin like modifier 1	Homo sapiens	37-47
22044919-2	2012	Given that SIRT1 inhibits the transactivation potential of NF-kappaB by deacetylating acetylated lysines in p65, the NF-kappaB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes.	Lysine	97-104	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-111
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	88-91	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
10447205-0	1999	Crystal structure of mung bean inhibitor lysine active fragment complex with bovine beta-trypsin at 1.8A resolution.	Lysine	41-47	serine protease 1	Bos taurus	84-96
10447205-1	1999	The crystal structure of the complex of mung bean inhibitor lysine active fragment with bovine beta-trypsin has been determined by X-ray crystallographic analysis at a resolution of 1.8 A. Refinement of the model of the complex converged at a final R value of 0.16.	Lysine	60-66	serine protease 1	Bos taurus	95-107
22214662-3	2012	Here, we report that RAX/PACT interacts with the SUMO E2 ligase Ubc9 to stimulate p53-Ubc9 association and reversible p53 sumoylation on lysine 386.	Lysine	137-143	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	25-29
10330133-7	1999	On the other hand, a 49-amino-acid segment, rich in lysines and arginines and located immediately downstream of the p105(Rb) interaction domain, appeared to be essential in this assay.	Lysine	52-59	RB transcriptional corepressor 1	Homo sapiens	116-124
16617102-4	2006	Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence.	Lysine	54-60	BCAS3 microtubule associated cell migration factor	Homo sapiens	186-191
22214662-3	2012	Here, we report that RAX/PACT interacts with the SUMO E2 ligase Ubc9 to stimulate p53-Ubc9 association and reversible p53 sumoylation on lysine 386.	Lysine	137-143	ubiquitin conjugating enzyme E2 I	Homo sapiens	64-68
16525503-0	2006	An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.	Lysine	12-18	TER94	Drosophila melanogaster	45-48
16525503-0	2006	An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.	Lysine	12-18	TER94	Drosophila melanogaster	49-52
22178397-6	2012	Upon heat shock, HSF triggers these PARP activities mechanistically by directing Tip60 acetylation of histone H2A lysine 5 at the 5" end of Hsp70, where inactive PARP resides before heat shock.	Lysine	114-120	Heat shock factor	Drosophila melanogaster	17-20
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Lysine	168-174	TER94	Drosophila melanogaster	130-133
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Lysine	168-174	TER94	Drosophila melanogaster	218-221
10346906-7	1999	Electron transfer in the complex of horse Cc (hCc) and CcP was examined using Ru-27-Cc, in which hCc is labeled with trisbipyridylruthenium(II) at Lys-27.	Lysine	147-150	HCC	Homo sapiens	42-44
10346906-7	1999	Electron transfer in the complex of horse Cc (hCc) and CcP was examined using Ru-27-Cc, in which hCc is labeled with trisbipyridylruthenium(II) at Lys-27.	Lysine	147-150	HCC	Homo sapiens	46-49
10346906-7	1999	Electron transfer in the complex of horse Cc (hCc) and CcP was examined using Ru-27-Cc, in which hCc is labeled with trisbipyridylruthenium(II) at Lys-27.	Lysine	147-150	HCC	Homo sapiens	47-49
10346906-7	1999	Electron transfer in the complex of horse Cc (hCc) and CcP was examined using Ru-27-Cc, in which hCc is labeled with trisbipyridylruthenium(II) at Lys-27.	Lysine	147-150	HCC	Homo sapiens	97-100
16566581-4	2006	In particular, the NHS-biotin modification approach was used to identify the lysine residues that are exposed to the solvent in free Gag and are protected from biotinylation by direct protein-ligand or protein-protein contacts in Gag complexes with PI(4,5)P2 and/or RNA.	Lysine	77-83	Pr55(Gag)	Human immunodeficiency virus 1	133-136
22178397-6	2012	Upon heat shock, HSF triggers these PARP activities mechanistically by directing Tip60 acetylation of histone H2A lysine 5 at the 5" end of Hsp70, where inactive PARP resides before heat shock.	Lysine	114-120	Heat-shock-protein-70Ab	Drosophila melanogaster	140-145
16566581-4	2006	In particular, the NHS-biotin modification approach was used to identify the lysine residues that are exposed to the solvent in free Gag and are protected from biotinylation by direct protein-ligand or protein-protein contacts in Gag complexes with PI(4,5)P2 and/or RNA.	Lysine	77-83	Pr55(Gag)	Human immunodeficiency virus 1	230-233
16566581-5	2006	Of 21 surface lysines readily modified in free Gag, only K30 and K32, located in the matrix domain, were strongly protected in the Gag-PI(4,5)P2 complex.	Lysine	14-21	Pr55(Gag)	Human immunodeficiency virus 1	47-50
10329734-5	1999	Variations in the side chain size and charge of this residue did not inhibit the specific activity of the H,K-ATPase, but reversal of the side chain charge by substitution of Lys or Arg for Glu produced a reciprocal change in the sensitivity of the H,K-ATPase to K+ and SCH 28080.	Lysine	175-178	dynein axonemal heavy chain 8	Homo sapiens	253-259
10329734-6	1999	The K0.5 for K+stimulated ATPase was decreased to 0.2 +/-.05 and 0.2 +/-.03 mM, respectively, in Lys-857 and Arg-857 site mutants, whereas the Ki for SCH 28080-dependent inhibition was increased to 6.5 +/- 1.4 and 5.9 +/- 1.5 microM, respectively.	Lysine	97-100	dynein axonemal heavy chain 8	Homo sapiens	26-32
22238793-10	2004	(111)In-Labeled diethylenetriamine pentaacetic acid-aminohexanoic acid-Lys(40)-exendin-4 ((111)In-DTPA-Ahx-Lys(40)-exendin-4) has been developed for single-photon emission computed tomography (SPECT) imaging of the GLP-1R (6).	Lysine	71-74	glucagon like peptide 1 receptor	Homo sapiens	215-221
10233073-9	1999	To accomplish this goal, PLB was labeled at Lys-3 in the cytoplasmic domain, with two different amine-reactive donor/acceptor pairs, which gave very similar FET results.	Lysine	44-47	phospholamban	Homo sapiens	25-28
10194416-8	1999	Addition of NH4+ triggers rapid poly-ubiquitination of Gap1p, the poly-ubiquitin chains being specifically formed by linkage through the lysine 63 residue of ubiquitin.	Lysine	137-143	ubiquitin	Saccharomyces cerevisiae S288C	71-80
22020126-3	2012	The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site.	Lysine	190-196	lysine acetyltransferase 8	Homo sapiens	108-111
16892378-2	2006	Here, we describe the first experimental evidence for the behavior of an old family of analgesic dipeptides, namely Xaa-Trp(Nps) and Trp(Nps)-Xaa (Xaa=Lys, Arg) derivatives, as potent TRPV1 channel blockers.	Lysine	151-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	184-189
22020126-5	2012	Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro.	Lysine	128-134	lysine acetyltransferase 8	Homo sapiens	161-165
23275711-4	2012	The docking simulation revealed that GA possibly inhibits functions of HMGB1 interfering with Lys(90), Arg(91), Ser(101), Tyr(149), C(230) and C(231) in the HMGB1-DNA complex.	Lysine	94-97	high mobility group box 1	Homo sapiens	71-76
16443219-5	2006	The putative PDGF-C SUMOylation site is the surface exposed (314)lysine part of a positively charged loop ((312)RPKTGVRGLHK(322)) with characteristics of a nuclear localisation signal.	Lysine	65-71	platelet derived growth factor C	Homo sapiens	13-19
10216163-3	1999	We identify Lys-132 in the Sdh4p C-terminal region as necessary for enzyme stability, ubiquinone reduction, and cytochrome b562 assembly in SDH.	Lysine	12-15	cytochrome b	Saccharomyces cerevisiae S288C	112-124
10222201-1	1999	The high-resolution X-ray structures have been determined for ten complexes formed between bovine beta-trypsin and P1 variants (Gly, Asp, Glu, Gln, Thr, Met, Lys, His, Phe, Trp) of bovine pancreatic trypsin inhibitor (BPTI).	Lysine	158-161	serine protease 1	Bos taurus	98-110
23275711-4	2012	The docking simulation revealed that GA possibly inhibits functions of HMGB1 interfering with Lys(90), Arg(91), Ser(101), Tyr(149), C(230) and C(231) in the HMGB1-DNA complex.	Lysine	94-97	high mobility group box 1	Homo sapiens	157-162
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	cullin 1	Homo sapiens	79-85
23047103-3	2012	The uptake of lysine and arginine by whole cells was little affected by deletion of the VBA5 gene, but was stimulated by overexpression of the VBA5 gene.	Lysine	14-20	basic amino acid transporter	Saccharomyces cerevisiae S288C	88-92
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	NEDD8 ubiquitin like modifier	Homo sapiens	257-262
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	273-276	cullin 1	Homo sapiens	50-56
16438933-7	2006	Plasmin pre-digestion increased the cofactor efficiency (related to C-terminal lysine exposure) and did not affect profoundly the structure of the aggregates, suggesting a long-lasting and even a self-augmenting cofactor function of the denatured protein.	Lysine	79-85	plasminogen	Homo sapiens	0-7
23047103-3	2012	The uptake of lysine and arginine by whole cells was little affected by deletion of the VBA5 gene, but was stimulated by overexpression of the VBA5 gene.	Lysine	14-20	basic amino acid transporter	Saccharomyces cerevisiae S288C	143-147
16522085-3	2006	The N-terminal domain of ribosomal protein L9 (NTL9) has a lysine residue at position 12, which makes strong non-native interactions in the unfolded state.	Lysine	59-65	ribosomal protein L9	Homo sapiens	25-45
10194307-5	1999	PLB was labeled, specifically at Lys 3 in the cytoplasmic domain, with amine-reactive fluorescent donor/acceptor pairs.	Lysine	33-36	phospholamban	Homo sapiens	0-3
21385071-8	2012	A novel de novo missense mutation 373G&gt;A was identified within the EFNB1 gene, leading to the replacement of glutamic acid at amino acid position 125 with lysine.	Lysine	158-164	ephrin B1	Homo sapiens	70-75
10026282-3	1999	Lp(a) binds lysine-Sepharose via a lysine binding site (LBS) located in KIV-10 (88% homology with plasminogen K4).	Lysine	12-18	lipoprotein(a)	Homo sapiens	0-5
10026282-3	1999	Lp(a) binds lysine-Sepharose via a lysine binding site (LBS) located in KIV-10 (88% homology with plasminogen K4).	Lysine	35-41	lipoprotein(a)	Homo sapiens	0-5
16339921-8	2006	However, titin exon transcript studies revealed up-regulation of seven exons, which code for spring elements in the elastic segment rich in proline, glutamate, valine, and lysine.	Lysine	172-178	titin	Homo sapiens	9-14
16339921-12	2006	Our results suggest that alternative splicing of the titin gene, resulting in increased length of the elastic segment rich in proline, glutamate, valine, and lysine, is involved.	Lysine	158-164	titin	Homo sapiens	53-58
10026282-4	1999	However, the W72R substitution that occurs in rhesus monkeys and occasionally in humans leads to impaired lysine binding capacity of KIV-10 and Lp(a).	Lysine	106-112	lipoprotein(a)	Homo sapiens	144-149
22708559-5	2012	In addition to these enzymes, proteins containing the bromodomain, a protein module named after the fly protein Brahma (God of creation in Hindu), are relevant to lysine acetylation biology due to their ability to recognize acetyl-lysine-containing peptides.	Lysine	163-169	brahma	Drosophila melanogaster	112-118
17163635-2	2006	Recent work using the yeast ubiquitin ligase SCF(Cdc4) and the ubiquitin conjugating enzyme, Cdc34, has helped to answer these questions by identifying the determinants of lysine-48 specific ubiquitin chain polymerization.	Lysine	172-178	SCF ubiquitin ligase complex subunit CDC4	Saccharomyces cerevisiae S288C	49-53
22389628-4	2012	In response to retinoic acid, CBP/p300 acetylates p53 at lysine 373, which leads to dissociation from E3-ubiquitin ligases HDM2 and TRIM24.	Lysine	57-63	E1A binding protein p300	Homo sapiens	34-38
9973276-2	1999	Recently, an isoleucine--&gt;lysine polymorphism at codon 1307 (I1307K) of the APC gene has been identified in 6%-7% of the Ashkenazi Jewish population.	Lysine	29-35	APC regulator of WNT signaling pathway	Homo sapiens	79-82
9891054-5	1999	In this study, we demonstrate that PCAF also acetylates p53 in vitro at a lysine residue distinct from that acetylated by p300 and thereby increases p53"s ability to bind to its cognate DNA site.	Lysine	74-80	lysine acetyltransferase 2B	Homo sapiens	35-39
9891054-6	1999	We have generated antibodies to acetylated p53 peptides at either of the two lysine residues that are targeted by PCAF or p300 and have demonstrated that these antibodies are highly specific for both acetylation and the particular site.	Lysine	77-83	lysine acetyltransferase 2B	Homo sapiens	114-118
9891054-6	1999	We have generated antibodies to acetylated p53 peptides at either of the two lysine residues that are targeted by PCAF or p300 and have demonstrated that these antibodies are highly specific for both acetylation and the particular site.	Lysine	77-83	E1A binding protein p300	Homo sapiens	122-126
16455797-6	2006	SSAT was found to self-acetylate lysine-26 in the presence of AcCoA and absence of substrate, a reaction apparently catalzyed by AcCoA bound in the second channel of the asymmetric dimer.	Lysine	33-39	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	0-4
16449638-8	2006	Neddylation of Cul3 on Lys 712 is required for Keap1-dependent ubiquitination of Nrf2 in vivo.	Lysine	23-26	cullin 3	Homo sapiens	15-19
9923762-6	1999	This mutation, which is predicted to cause a missense substitution of lysine for glutamic acid, occurred at codon 123 of PS1 that was not a conserved residue in PS2.	Lysine	70-76	presenilin 1	Homo sapiens	121-124
23118980-5	2012	Here we report that NEDD8 is conjugated to RCAN1 (RCAN1-1S) via three lysine residues, K96, K104, and K107.	Lysine	70-76	NEDD8 ubiquitin like modifier	Homo sapiens	20-25
10079520-4	1999	In this report, we have further analyzed the functional importance of N-cadherin in the cellular condensation-chondrogenesis pathway by examining N-cadherin expression and related activities in high density micromass cultures of chick limb mesenchymal cells in which chondrogenesis is being stimulated with the cationic polymer, poly-L-lysine (PL).	Lysine	329-342	cadherin 2	Gallus gallus	70-80
16449642-5	2006	This effect is mediated by the previously described association of PML-RAR with chromatin-modifying enzymes (histone deacetylases and DNA methyltransferases) and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3.	Lysine	253-259	PML-RARA regulated adaptor molecule 1	Homo sapiens	67-74
23024815-0	2012	The histone H4 lysine 20 monomethyl mark, set by PR-Set7 and stabilized by L(3)mbt, is necessary for proper interphase chromatin organization.	Lysine	15-21	PR/SET domain containing protein 7	Drosophila melanogaster	49-56
16430207-4	2006	One residue, Arg(6), was found to be essential for receptor antagonism; its replacement with either alanine or lysine completely abolished the interaction between AF17121 and IL5Ralpha.	Lysine	111-117	interleukin 5 receptor subunit alpha	Homo sapiens	175-184
16291740-4	2006	This activity is independent of MDM2 but requires a p53 nuclear export signal and acetylation of multiple lysines by p300.	Lysine	106-113	E1A binding protein p300	Homo sapiens	117-121
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-77	E1A binding protein p300	Homo sapiens	115-119
16291740-5	2006	Mechanistically, we showed that conversion of a minimal four of these lysines to alanines but not arginines mimics p300-mediated p53 nuclear export, and these lysine-neutralizing mutations effectively prevent p53 tetramerization, thus exposing the oligomerization-regulated nuclear export signal.	Lysine	70-76	E1A binding protein p300	Homo sapiens	115-119
9886404-4	1999	In the crystal structure of the HLA-DR2/MBP peptide complex, P5 lysine is a prominent, solvent-exposed residue in the center of the DR2/MBP peptide surface.	Lysine	64-70	myelin basic protein	Homo sapiens	40-43
9886404-4	1999	In the crystal structure of the HLA-DR2/MBP peptide complex, P5 lysine is a prominent, solvent-exposed residue in the center of the DR2/MBP peptide surface.	Lysine	64-70	myelin basic protein	Homo sapiens	136-139
23024815-1	2012	Drosophila PR-Set7 or SET8 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (H4K20).	Lysine	102-108	PR/SET domain containing protein 7	Drosophila melanogaster	11-18
23024815-1	2012	Drosophila PR-Set7 or SET8 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (H4K20).	Lysine	102-108	PR/SET domain containing protein 7	Drosophila melanogaster	22-26
16354780-11	2006	Our previous results showed that both lysine and arginine mediate escapin"s bacteriostatic effects, but only lysine mediates its bactericidal effects.	Lysine	38-44	L-amino-acid oxidase	Aplysia californica	66-73
10386039-4	1999	In this work is analysed endonuclease activity of recombinant pancreatic RNase A (K7H), that in position seven instead of a lysine there is a histidine, amino acid residue that participates in main catalytic site p1.	Lysine	124-130	ribonuclease A family member 1, pancreatic	Homo sapiens	73-80
16354780-12	2006	Given that escapin"s antimicrobial effects require concentrations of lysine and/or arginine &gt;1 mmol l(-1), our data lead us to conclude that lysine in opaline is the primary natural substrate for escapin in ink.	Lysine	69-75	L-amino-acid oxidase	Aplysia californica	11-18
22860050-7	2012	We identified p65 lysines (K) 122 and 123 as target residues mediating the CCTeta-driven termination of NF-kappaB-dependent transcription.	Lysine	18-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	14-17
16354780-12	2006	Given that escapin"s antimicrobial effects require concentrations of lysine and/or arginine &gt;1 mmol l(-1), our data lead us to conclude that lysine in opaline is the primary natural substrate for escapin in ink.	Lysine	144-150	L-amino-acid oxidase	Aplysia californica	11-18
16354780-12	2006	Given that escapin"s antimicrobial effects require concentrations of lysine and/or arginine &gt;1 mmol l(-1), our data lead us to conclude that lysine in opaline is the primary natural substrate for escapin in ink.	Lysine	144-150	L-amino-acid oxidase	Aplysia californica	199-206
16354780-13	2006	Furthermore, packaging of the enzyme escapin and its substrate lysine into two separate glands and their co-release and mixing at the time of predatory attack allows for the generation of bioactive defensive compounds from innocuous precursors at the precise time they are needed.	Lysine	63-69	L-amino-acid oxidase	Aplysia californica	37-44
16354780-14	2006	Whether lysine and/or arginine are substrates for escapin"s antipredatory functions remains to be determined.	Lysine	8-14	L-amino-acid oxidase	Aplysia californica	50-57
10386039-6	1999	Results of this investigation have shown that substitution of lysine by histidine in position seven of RNase A has produced total deletion of p2 subsite, and K7H has lost endonuclease activity, and has become exonuclease.	Lysine	62-68	ribonuclease A family member 1, pancreatic	Homo sapiens	103-110
10386039-7	1999	These results confirm central role of Lys-7 in establishing p2 subsite and endonuclease activity of pancreatic RNase A.	Lysine	38-41	ribonuclease A family member 1, pancreatic	Homo sapiens	111-118
9837944-1	1998	Among the polar interactions occurring in pancreatic lipase/colipase binding, only one ion pair involving lysine 400 on lipase and glutamic acid 45 on colipase has been described.	Lysine	106-112	colipase	Equus caballus	60-68
9837944-1	1998	Among the polar interactions occurring in pancreatic lipase/colipase binding, only one ion pair involving lysine 400 on lipase and glutamic acid 45 on colipase has been described.	Lysine	106-112	colipase	Equus caballus	151-159
22693631-2	2012	As other ubiquitin-like proteins (Ubls), ISG15 is post-translationally conjugated to substrate proteins by an isopeptide bond between the C-terminal glycine of ISG15 and the side chains of lysine residues in the substrates (ISGylation).	Lysine	189-195	ISG15 ubiquitin like modifier	Homo sapiens	41-46
9801446-6	1998	A single fatty acid moiety was linked to RNase A through the alpha-amino group of its N-terminal lysine as shown by powerful analytical techniques.	Lysine	97-103	ribonuclease A family member 1, pancreatic	Homo sapiens	41-48
16210244-6	2006	In addition, we found that this variant H2A is methylated on the epsilon amino group of lysine residues Lys(17), Lys(122), and Lys(238) and phosphorylated on Thr(128).	Lysine	88-94	H2A clustered histone 18	Homo sapiens	40-43
16210244-6	2006	In addition, we found that this variant H2A is methylated on the epsilon amino group of lysine residues Lys(17), Lys(122), and Lys(238) and phosphorylated on Thr(128).	Lysine	104-107	H2A clustered histone 18	Homo sapiens	40-43
16210244-6	2006	In addition, we found that this variant H2A is methylated on the epsilon amino group of lysine residues Lys(17), Lys(122), and Lys(238) and phosphorylated on Thr(128).	Lysine	113-116	H2A clustered histone 18	Homo sapiens	40-43
16210244-6	2006	In addition, we found that this variant H2A is methylated on the epsilon amino group of lysine residues Lys(17), Lys(122), and Lys(238) and phosphorylated on Thr(128).	Lysine	113-116	H2A clustered histone 18	Homo sapiens	40-43
22701532-1	2012	Mutations in the WNK1 gene, encoding a serine-threonine kinase of the WNK (With No lysine (K)) family, have been implicated in two rare human diseases, Familial Hyperkalemic Hypertension (FHHt) and Hereditary Sensory and Autonomic Neuropathy type 2 (HSAN2).	Lysine	83-89	WNK lysine deficient protein kinase 1	Homo sapiens	17-21
9806977-4	1998	Binding of unlabeled pili to MG2 and CsnSN could be abolished by treatment of HSMSL with trypsin to hydrolyze the peptide moieties or N-acetylation to neutralize the positive charges of the lysine residues.	Lysine	190-196	mucin 7, secreted	Homo sapiens	29-32
16543973-5	2006	Our results show that r-apo(a) binds to these cells with higher affinity than plasminogen [K(d) = 0.9 +/- 0.2 microM for plasminogen, K(d) = 1.77 +/- 0.34 nM for r-apo(a)] in a lysine-dependent manner.	Lysine	177-183	lipoprotein(a)	Homo sapiens	24-30
22539995-7	2012	PIAS1 promoted SUMO-1 modification of GATA4 on lysine 366.	Lysine	47-53	small ubiquitin like modifier 1	Homo sapiens	15-21
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	126-132	stromal antigen 3	Mus musculus	43-48
10052628-1	1998	The conformational preference of the gonadotropin-releasing hormone (GnRH) and its Lys-8 mutant, studied earlier with a continuum model, was revisited using an explicit solvent model and thermodynamic integration to calculate the solvents contribution to the conformation-dependence of its free energy.	Lysine	83-86	gonadotropin releasing hormone 1	Homo sapiens	69-73
22514644-1	2012	JMJD2D, also known as KDM4D, is a histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4.	Lysine	88-94	lysine demethylase 4D	Homo sapiens	0-6
9787161-9	1998	Thus our studies suggest that whereas the C-terminal lysine residues of PF4 are important for heparin binding, they do not comprise a critical antigenic site for most HIT antibodies.	Lysine	53-59	platelet factor 4	Homo sapiens	72-75
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	126-132	E2F transcription factor 6	Mus musculus	52-56
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	139-145	stromal antigen 3	Mus musculus	43-48
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	139-145	E2F transcription factor 6	Mus musculus	52-56
16204234-4	2005	Here we show that PARP-1 is acetylated in vivo at specific lysine residues by p300/CREB-binding protein upon stimulation.	Lysine	59-65	E1A binding protein p300	Homo sapiens	78-82
22514644-1	2012	JMJD2D, also known as KDM4D, is a histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4.	Lysine	88-94	lysine demethylase 4D	Homo sapiens	22-27
22514644-1	2012	JMJD2D, also known as KDM4D, is a histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4.	Lysine	119-125	lysine demethylase 4D	Homo sapiens	0-6
9790687-2	1998	BNP was tentatively identified as a heparin-binding protein on the basis of its cyclic structure and the high frequency of the basic amino acid residues, lysine and arginine.	Lysine	154-160	natriuretic peptide B	Homo sapiens	0-3
22514644-1	2012	JMJD2D, also known as KDM4D, is a histone demethylase that removes methyl moieties from lysine 9 on histone 3 and from lysine 26 on histone 1.4.	Lysine	119-125	lysine demethylase 4D	Homo sapiens	22-27
16288922-7	2005	Moreover, our structure-based analysis reveals that individual mutation of the conserved Arg294 and Arg295 that likely comprise the phosphothreonine-binding pocket in PAC-1 to either alanine or lysine results in a nearly complete loss of its phosphatase activity even in the presence of ERK2.	Lysine	194-200	dual specificity phosphatase 2	Homo sapiens	167-172
22384255-9	2012	This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.	Lysine	24-30	microRNA 200c	Homo sapiens	88-96
16183991-4	2005	Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway.	Lysine	73-79	RELA proto-oncogene, NF-kB subunit	Homo sapiens	61-65
16183991-4	2005	Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway.	Lysine	73-79	RELA proto-oncogene, NF-kB subunit	Homo sapiens	66-69
9893941-15	1998	Crystal structures of cytochrome c oxidase show that this lysine is at the N entrance of a channel which translocates the protons consumed for the production of the peroxy intermediate.	Lysine	58-64	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	22-42
22363466-0	2012	Lysine residue at position 22 of the AID protein regulates its class switch activity.	Lysine	0-6	activation induced cytidine deaminase	Homo sapiens	37-40
9778298-6	1998	RESULTS: Sequencing of the PCR product revealed a 6-base deletion (TTCAAA) at nucleotides 601 to 606, resulting in a two-amino-acid deletion in the POU3F4 protein, (phenylalanine and lysine at amino acid residues 201 and 202).	Lysine	183-189	POU class 3 homeobox 4	Homo sapiens	148-154
16235027-3	2005	We now demonstrate that many of its 16 lysine residues can serve as alternative acceptors for ubiquitination to maintain the monoubiquitination status of DEDD.	Lysine	39-45	death effector domain containing	Homo sapiens	154-158
16287862-0	2005	H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases.	Lysine	3-9	SU(VAR)3-9 homolog 6	Arabidopsis thaliana	93-98
22363466-3	2012	Although ubiquitination at lysine residues of AID is recognized as an essential step in initiating degradation of nuclear AID, any functional relevance of lysine modifications has remained elusive.	Lysine	27-33	activation induced cytidine deaminase	Homo sapiens	46-49
16287862-0	2005	H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases.	Lysine	3-9	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	103-108
9809067-2	1998	We show that CBP and P/CAF acetylate HMG I(Y), the essential architectural component required for enhanceosome assembly, at distinct lysine residues, causing distinct effects on transcription.	Lysine	133-139	lysine acetyltransferase 2B	Homo sapiens	21-26
22363466-3	2012	Although ubiquitination at lysine residues of AID is recognized as an essential step in initiating degradation of nuclear AID, any functional relevance of lysine modifications has remained elusive.	Lysine	27-33	activation induced cytidine deaminase	Homo sapiens	122-125
9792107-5	1998	Experiments using 10 mM 6-aminohexanoic acid or 50 mM benzamidine demonstrate that either of these two lysine analogues abolishes interaction of domain B with Plg.	Lysine	103-109	plasminogen	Homo sapiens	159-162
9792107-10	1998	These results show that SK domain B interacts with Plg in a lysine-dependent manner and that although domains A and C do not appear independently to possess affinity for Plg, they function cooperatively to establish the additional interactions with Plg to form an efficient native-like Plg activator complex.	Lysine	60-66	plasminogen	Homo sapiens	51-54
22363466-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Here, we report functional implications of lysine modifications of the human AID protein by generating a panel of lysine to arginine mutants of AID and assessment of their catalytic class switch activity.	Lysine	75-81	activation induced cytidine deaminase	Homo sapiens	109-112
22363466-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Here, we report functional implications of lysine modifications of the human AID protein by generating a panel of lysine to arginine mutants of AID and assessment of their catalytic class switch activity.	Lysine	75-81	activation induced cytidine deaminase	Homo sapiens	176-179
22363466-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Here, we report functional implications of lysine modifications of the human AID protein by generating a panel of lysine to arginine mutants of AID and assessment of their catalytic class switch activity.	Lysine	146-152	activation induced cytidine deaminase	Homo sapiens	109-112
22363466-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Here, we report functional implications of lysine modifications of the human AID protein by generating a panel of lysine to arginine mutants of AID and assessment of their catalytic class switch activity.	Lysine	146-152	activation induced cytidine deaminase	Homo sapiens	176-179
9730840-3	1998	It encoded a 76 residue MCP-2 protein, but differed from the reported bone marrow-derived MCP-2 cDNA sequence in codon 46, which coded for a Lys instead of a Gln.	Lysine	141-144	C-C motif chemokine ligand 8	Homo sapiens	90-95
16299514-5	2005	We demonstrated that the ADA2alpha SWIRM domain is colocalized with lysine-acetylated histone H3 in the cell nucleus and that it potentiates the ACF remodeling activity by enhancing accessibility of nucleosomal linker DNA bound to histone H1.	Lysine	68-74	transcriptional adaptor 2A	Homo sapiens	25-34
22363466-7	2012	CONCLUSIONS/SIGNIFICANCE: Our results imply that lysine modification may represent a novel level of AID regulation and that Lys22 is important for effective AID activity.	Lysine	49-55	activation induced cytidine deaminase	Homo sapiens	100-103
22084441-3	2011	The lysine residue responsible for DAP12 association is absent in rat and mouse NKG2C and -E, raising questions about signaling mechanisms in these species.	Lysine	4-10	transmembrane immune signaling adaptor Tyrobp	Rattus norvegicus	35-40
16307304-0	2005	Chemical modification studies of tryptophan, arginine and lysine residues in maize chloroplast ferredoxin:sulfite oxidoreductase.	Lysine	58-64	ferredoxin	Zea mays	95-105
9733991-10	1998	When direct uptake measurements were carried out, both lysine and arginine were found to be effective substrates for RcAAP1.	Lysine	55-61	amino acid permease 3	Ricinus communis	117-123
22084441-3	2011	The lysine residue responsible for DAP12 association is absent in rat and mouse NKG2C and -E, raising questions about signaling mechanisms in these species.	Lysine	4-10	killer cell lectin-like receptor subfamily C, member 2	Mus musculus	80-92
16307304-0	2005	Chemical modification studies of tryptophan, arginine and lysine residues in maize chloroplast ferredoxin:sulfite oxidoreductase.	Lysine	58-64	oxidoreductase	Zea mays	114-128
21939789-6	2011	This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin.	Lysine	45-48	alpha-1-microglobulin/bikunin precursor	Homo sapiens	138-145
16120648-3	2005	Our results further show that human ADAR1 is modified by SUMO-1 on lysine residue 418.	Lysine	67-73	small ubiquitin like modifier 1	Homo sapiens	57-63
16087677-8	2005	Plasmin generated cleavage sites at Lys(114) downward arrowArg(115) and Lys(129) downward arrowVal(130) in the ectodomain of syndecan-4.	Lysine	36-39	plasminogen	Homo sapiens	0-7
16087677-8	2005	Plasmin generated cleavage sites at Lys(114) downward arrowArg(115) and Lys(129) downward arrowVal(130) in the ectodomain of syndecan-4.	Lysine	36-39	syndecan 4	Homo sapiens	125-135
9732313-4	1998	The isotopic enrichments of apoB-100-bound [U-13C]threonine, leucine, lysine and phenylalanine were 33, 100, 194 and 230% higher than those of their respective hepatic free amino acid pools (P &lt; 0.01).	Lysine	70-76	apolipoprotein B	Sus scrofa	28-36
9710596-4	1998	Specifically, we observe decreased acetylation of histones H3 and H4 (preferentially lysines 5 and 12) that depends on the DNA-binding repressor (Ume6), Sin3, and Rpd3.	Lysine	85-92	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	146-150
9710596-4	1998	Specifically, we observe decreased acetylation of histones H3 and H4 (preferentially lysines 5 and 12) that depends on the DNA-binding repressor (Ume6), Sin3, and Rpd3.	Lysine	85-92	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	153-157
16087677-8	2005	Plasmin generated cleavage sites at Lys(114) downward arrowArg(115) and Lys(129) downward arrowVal(130) in the ectodomain of syndecan-4.	Lysine	72-75	plasminogen	Homo sapiens	0-7
16087677-8	2005	Plasmin generated cleavage sites at Lys(114) downward arrowArg(115) and Lys(129) downward arrowVal(130) in the ectodomain of syndecan-4.	Lysine	72-75	syndecan 4	Homo sapiens	125-135
21985982-2	2011	The cytoplasmic tails of Delta ligands have multiple potential regulatory sites including several lysine residues that are putative targets for ubiquitination by the E3 ubiquitin ligases, Mind Bomb and Neuralized.	Lysine	98-104	WW and C2 domain containing 2	Homo sapiens	188-197
16087677-9	2005	In thrombin proteolysates of the syndecan-4 ectodomain, the cleavage site Lys(114) downward arrowArg(115) was also identified.	Lysine	74-77	syndecan 4	Homo sapiens	33-43
9759626-3	1998	A nucleotide 1648 G/A dimorphism that leads to a Glu/Lys substitution at amino acid 505 is responsible for the human platelet antigen system, HPA-5.	Lysine	53-56	integrin subunit alpha 2	Homo sapiens	142-147
21470372-0	2011	Homozygous Hb Stanleyville-II [alpha2 78(EF7) Asn&gt;Lys; HBA2:c.237C&gt;A, not C&gt;G] associated with genotype -alpha 3.7/-alpha 3.7 in two Brazilian families.	Lysine	53-56	hemoglobin subunit alpha 2	Homo sapiens	58-62
9707628-4	1998	The structural basis of this unusual function of the neuraminidase molecule appears to be the presence of a carboxyl-terminal lysine and the absence of an oligosaccharide side chain at position 146 (N2 numbering).	Lysine	126-132	neuraminidase 1	Homo sapiens	53-66
9694859-0	1998	Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting.	Lysine	0-6	cathepsin D	Homo sapiens	76-87
9694859-2	1998	In this study, the involvement of specific lysine residues in mannose phosphorylation of cathepsin D was explored by site-directed mutagenesis.	Lysine	43-49	cathepsin D	Homo sapiens	89-100
9694859-6	1998	On both molecules, the lysine residues were positioned approximately 34 A apart (34.06 A for cathepsin D and 33.80 A for cathepsin L).	Lysine	23-29	cathepsin D	Homo sapiens	93-104
16081416-2	2005	Previously, we generated a lysosomal enzyme recognition domain in the secretory protein glycopepsinogen by substituting in two regions (lysine 203 and amino acids 265-293 of the beta loop) from cathepsin D, a highly related lysosomal protease.	Lysine	136-142	cathepsin D	Homo sapiens	194-205
16081416-4	2005	Substitution of additional residues in the beta loop, particularly lysines, increased phosphorylation 4-fold further, approaching the level obtained with intact cathepsin D.	Lysine	67-74	cathepsin D	Homo sapiens	161-172
21908771-7	2011	In addition, we demonstrate that Sirt5, a member of the class III lysine deacetylases, can catalyze lysine demalonylation and lysine desuccinylation reactions both in vitro and in vivo.	Lysine	66-72	sirtuin 5	Homo sapiens	33-38
16157865-2	2005	Here, we report histone H3-tail lysine methylation profiles of several Arabidopsis genes in correlation with their transcriptional activity and the input of the epigenetic factor ARABIDOPSIS HOMOLOG OF TRITHORAX (ATX1) at ATX1-regulated loci.	Lysine	32-38	homolog of anti-oxidant 1	Arabidopsis thaliana	213-217
16157865-2	2005	Here, we report histone H3-tail lysine methylation profiles of several Arabidopsis genes in correlation with their transcriptional activity and the input of the epigenetic factor ARABIDOPSIS HOMOLOG OF TRITHORAX (ATX1) at ATX1-regulated loci.	Lysine	32-38	homolog of anti-oxidant 1	Arabidopsis thaliana	222-226
9685390-7	1998	OCTN2-mediated L-[3H]carnitine transport was inhibited by the D-isomer, acetyl-D,L-carnitine, and gamma-butyrobetaine with high affinity and by glycinebetaine with lower affinity, whereas choline, beta-hydroxybutyric acid, gamma-aminobutyric acid, lysine, and taurine were not inhibitory.	Lysine	248-254	solute carrier family 22 member 5	Homo sapiens	0-5
9675168-1	1998	Titin, a 1-microm-long protein found in striated muscle myofibrils, possesses unique elastic and extensibility properties in its I-band region, which is largely composed of a PEVK region (70% proline, glutamic acid, valine, and lysine residue) and seven-strand beta-sandwich immunoglobulin-like (Ig) domains.	Lysine	228-234	titin	Homo sapiens	0-5
21908771-7	2011	In addition, we demonstrate that Sirt5, a member of the class III lysine deacetylases, can catalyze lysine demalonylation and lysine desuccinylation reactions both in vitro and in vivo.	Lysine	100-106	sirtuin 5	Homo sapiens	33-38
21807096-7	2011	N-terminal sequencing analysis showed that calpain cleaves VGLUT2 in the C-terminus, at Asn(534) and Lys(542).	Lysine	101-104	solute carrier family 17 member 6	Homo sapiens	59-65
9722314-4	1998	Another type I patient had a G to A base substitution in exon 12 resulting in a Glu (GAA)-324 to Lys (AAA) mutation (E324K).	Lysine	97-100	alpha glucosidase	Homo sapiens	85-88
16164414-2	2005	Yeast 6-phosphofructo-2-kinase (PFK2) was found to be acetylated at the amino acid lysine 3.	Lysine	83-89	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	32-36
20016921-2	2011	We have recently demonstrated that IN is acetylated by a cellular histone acetyltransferase, p300, which modifies three lysines located in the C-terminus of the viral factor (Cereseto et al.	Lysine	120-127	E1A binding protein p300	Homo sapiens	93-97
15937148-7	2005	Pre-exposure of SG neurons to the ORL1 receptor blocker, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101), significantly decreased the Noc-mediated Ca(2+) current inhibition.	Lysine	74-77	opioid related nociceptin receptor 1	Rattus norvegicus	34-38
9665813-3	1998	A direct relationship was found to exist between cell viability (propidium iodide uptake) and the magnitude of lysine-dependent plasminogen binding, with apoptotic and dead subpopulations of cells binding up to 100-fold more plasminogen than viable cells.	Lysine	111-117	plasminogen	Homo sapiens	128-139
9665813-3	1998	A direct relationship was found to exist between cell viability (propidium iodide uptake) and the magnitude of lysine-dependent plasminogen binding, with apoptotic and dead subpopulations of cells binding up to 100-fold more plasminogen than viable cells.	Lysine	111-117	plasminogen	Homo sapiens	225-236
9665813-4	1998	Despite the high level of lysine-dependent plasminogen binding on dead cells, plasminogen activation was minimal due to low levels of cell-surface urokinase plasminogen activator.	Lysine	26-32	plasminogen	Homo sapiens	43-54
9665813-5	1998	Plasminogen activation readily occurred on the surface of apoptotic cells because of a dramatic increase in both lysine-dependent plasminogen binding and endogenous urokinase plasminogen activator.	Lysine	113-119	plasminogen	Homo sapiens	0-11
9665813-5	1998	Plasminogen activation readily occurred on the surface of apoptotic cells because of a dramatic increase in both lysine-dependent plasminogen binding and endogenous urokinase plasminogen activator.	Lysine	113-119	plasminogen	Homo sapiens	130-141
15964846-0	2005	SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.	Lysine	97-103	lysine methyltransferase 5A	Homo sapiens	0-4
21795584-7	2011	Molecular docking revealed strong interaction of the ligand with the p65 via two hydrogen bonds one with Lys(37) (2.204 A) and another with Cys(38) (2.023 A).	Lysine	105-108	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
15964846-6	2005	Methylation assays with N terminus mutants of H4 that contain deletions and single alanine or glutamine substitutions of charged residues revealed that SET8 requires the sequence RHRK20VLRDN for methylation at lysine 20.	Lysine	210-216	lysine methyltransferase 5A	Homo sapiens	152-156
15964846-7	2005	The individual mutation of any charged residue in this sequence to alanine or glutamine abolished or greatly decreased levels of methylation of lysine 20 of H4 by SET8.	Lysine	144-150	lysine methyltransferase 5A	Homo sapiens	163-167
15964846-9	2005	Mass spectrometric analysis of synthesized H4 N-terminal peptides modified by SET8 showed that SET8 selectively mono-methylates lysine 20 of H4.	Lysine	128-134	lysine methyltransferase 5A	Homo sapiens	78-82
15964846-9	2005	Mass spectrometric analysis of synthesized H4 N-terminal peptides modified by SET8 showed that SET8 selectively mono-methylates lysine 20 of H4.	Lysine	128-134	lysine methyltransferase 5A	Homo sapiens	95-99
15964846-10	2005	Taken together, our results suggested that the coordination between the amino acid sequence RHRK20VLRDN and the SET domain of SET8 determines the substrate specificity and multiplicity of methylation of lysine 20 of H4.	Lysine	203-209	lysine methyltransferase 5A	Homo sapiens	126-130
9624159-4	1998	ACLP is a nonnuclear protein that contains a signal peptide, a lysine- and proline-rich 11-amino acid repeating motif, a discoidin-like domain, and a C-terminal domain with 39% identity to carboxypeptidase E.	Lysine	63-69	AE binding protein 1	Mus musculus	0-4
21878322-7	2011	A single lysine residue (Lys105) in recombinant CES1 was modified by HNE via a Michael addition reaction, whereas the lone reduced cysteine residue (Cys389) was found unmodified.	Lysine	9-15	carboxylesterase 1	Homo sapiens	48-52
9614060-6	1998	However, the apparent affinity for lysine transport was 2.4 times lower in Cat1(-/-) cells when compared with wild type cells, a property characteristic of Cat3-mediated transport.	Lysine	35-41	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	75-79
15963938-6	2005	We have used the ubiquitin-activating enzyme E1 and one of the ubiquitin-conjugating enzymes E2 to attach a fluorescent lysine derivative to the C terminus of ubiquitin.	Lysine	120-126	ubiquitin like modifier activating enzyme 7	Homo sapiens	17-47
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	20-26	small ubiquitin like modifier 1	Homo sapiens	98-104
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	small ubiquitin like modifier 1	Homo sapiens	98-104
9626144-9	1998	Guanine was replaced by adenine (GAA-->AAA), resulting in a substitution of lysine for glutamic acid (glu) at amino acid position 354 of the receptor.	Lysine	76-82	alpha glucosidase	Homo sapiens	33-36
21855605-2	2011	Many TRPA1 activators are reactive electrophiles that form Michael adducts with cysteine and lysine residues of TRPA1"s intracellular N-terminus.	Lysine	93-99	transient receptor potential cation channel subfamily A member 1	Homo sapiens	5-10
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	small ubiquitin like modifier 1	Homo sapiens	98-104
9565642-4	1998	Biochemical, T cell activation, and molecular modeling studies of mutant complexes demonstrate that the MBP peptide"s key residue for MHC binding, lysine 4, is buried in the P6 pocket of I-Au, which is predominantly hydrophobic.	Lysine	147-153	myelin basic protein	Mus musculus	104-107
21855605-2	2011	Many TRPA1 activators are reactive electrophiles that form Michael adducts with cysteine and lysine residues of TRPA1"s intracellular N-terminus.	Lysine	93-99	transient receptor potential cation channel subfamily A member 1	Homo sapiens	112-117
22028379-4	2011	Both the SUMOylation and K48-linked ubiquitination of IRF3 occurred at lysines 70 and 87, and these processes are competitive.	Lysine	71-78	interferon regulatory factor 3	Homo sapiens	54-58
9564049-3	1998	In the presence of ATP, hMutSalpha dissociated from mismatched oligonucleotide substrates, and this reaction was attenuated by mutating the conserved lysine in the ATP-binding domains of hMSH6, hMSH2 or both to arginine.	Lysine	150-156	mutS homolog 2	Homo sapiens	194-199
9564049-5	1998	The ATPase activity of hMutSalpha variants carrying the Lys--&gt;Arg mutation in hMSH2 or in hMSH6 was severely affected, but these mutants were still proficient in mismatch binding and were able to complement, albeit to different extents, mismatch repair-deficient cell extracts.	Lysine	56-59	dynein axonemal heavy chain 8	Homo sapiens	4-10
9564049-5	1998	The ATPase activity of hMutSalpha variants carrying the Lys--&gt;Arg mutation in hMSH2 or in hMSH6 was severely affected, but these mutants were still proficient in mismatch binding and were able to complement, albeit to different extents, mismatch repair-deficient cell extracts.	Lysine	56-59	mutS homolog 2	Homo sapiens	81-86
16002703-5	2005	Although a remarkable similarity was observed for most modifications, differences in magnitude between the HLA-DRA promoter for modifications associated with the assembly of the general transcription factors, such as histone H3 lysine 9 acetylation and H3 lysine 4 trimethylation, distinguished the very active HLA-DRA promoter from the XL box regions.	Lysine	228-234	major histocompatibility complex, class II, DR alpha	Homo sapiens	107-114
16002703-5	2005	Although a remarkable similarity was observed for most modifications, differences in magnitude between the HLA-DRA promoter for modifications associated with the assembly of the general transcription factors, such as histone H3 lysine 9 acetylation and H3 lysine 4 trimethylation, distinguished the very active HLA-DRA promoter from the XL box regions.	Lysine	256-262	major histocompatibility complex, class II, DR alpha	Homo sapiens	107-114
15879597-3	2005	By using purified proteins, FGF-2 is shown to directly interact through two separate domains with two RSK2 domains on both sides of the hydrophobic motif, namely the NH2-terminal kinase domain (residues 360-381) by amino acid Ser-117 and the COOH-terminal kinase domain (residues 388-400) by amino acids Leu-127 and Lys-128.	Lysine	316-319	fibroblast growth factor 2	Mus musculus	28-33
15870130-8	2005	Using photoaffinity labeling with (125)I-[azidobenzoyl-D-Lys(6)]GnRH-II, we observed that an 80-kDa protein specifically bound to GnRH-II.	Lysine	57-60	gonadotropin releasing hormone 2	Homo sapiens	64-71
9684731-2	1998	Apo(a) is a glycoprotein homologous to plasminogen as it contains multiple repeats of a lysine binding domain resembling plasminogen kringle IV (K.IV).	Lysine	88-94	lipoprotein(a)	Homo sapiens	0-6
9684731-4	1998	Since K.IV type 10 shows the highest conservation of the amino acids postulated to form the lysine binding pocket, this kringle is suggested to be the main lysine binding site of apo(a).	Lysine	92-98	lipoprotein(a)	Homo sapiens	179-185
15870130-8	2005	Using photoaffinity labeling with (125)I-[azidobenzoyl-D-Lys(6)]GnRH-II, we observed that an 80-kDa protein specifically bound to GnRH-II.	Lysine	57-60	gonadotropin releasing hormone 2	Homo sapiens	130-137
9684731-4	1998	Since K.IV type 10 shows the highest conservation of the amino acids postulated to form the lysine binding pocket, this kringle is suggested to be the main lysine binding site of apo(a).	Lysine	156-162	lipoprotein(a)	Homo sapiens	179-185
21791603-4	2011	Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.	Lysine	114-120	ring finger and CHY zinc finger domain containing 1	Homo sapiens	27-32
9684731-5	1998	Recently, a T--&gt;C polymorphism in the apo(a)-gene was reported, leading to a Met--&gt;Thr substitution at amino acid position 66 of K.IV type 10, in the vicinity of the postulated lysine binding pocket.	Lysine	183-189	lipoprotein(a)	Homo sapiens	41-47
9572144-0	1998	Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3.	Lysine	61-67	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	30-34
21808053-6	2011	The TREX1 residues Arg-174 and Lys-175 positioned adjacent to the active sites act with the Arg-128 residues positioned in the catalytic cores to facilitate melting of dsDNA and generate ssDNA for entry into the active sites.	Lysine	31-34	three prime repair exonuclease 1	Homo sapiens	4-9
9572144-8	1998	A deletion of RPD3 or SIN3, but not of the related histone-deacetylase gene HDA1, results in increased acetylation of the lysine 5 residue of H4 in the promoters of the UME6-regulated INO1, IME2 and SPO13 genes.	Lysine	122-128	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	22-26
15972587-5	2005	The ability of glutamine-lacking DPP to form polymers in vitro and in vivo demonstrates that it could act as a lysine donor for crosslinking, potentially having protein crosslinking partner(s) in teeth.	Lysine	111-117	dentin sialophosphoprotein	Homo sapiens	33-36
21813148-5	2011	Mutagenesis analysis identified three lysines at positions 66, 109 and 110 in BTas that are acetylated by p300.	Lysine	38-45	E1A binding protein p300	Homo sapiens	106-110
15992689-3	2005	Recently, a novel posttranslational modification has been identified: covalent binding of the vitamin biotin to lysine residues in histones, mediated by biotinidase and holocarboxylase synthetase.	Lysine	112-118	biotinidase	Homo sapiens	153-195
9548714-5	1998	Serines and a lysine are essential elements of the Ste2p SINNDAKSS internalization signal that can mediate both constitutive and ligand-stimulated endocytosis.	Lysine	14-20	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	51-56
9558075-5	1998	An arginine or lysine residue frequently appeared at position alpha93 in the CDR3 of the TCR alpha-chains from Hom-CTL restricted by HLA-A68 or -B8.	Lysine	15-21	CDR3	Homo sapiens	77-81
21813148-8	2011	These results suggest that the p300-acetylated lysines of BTas are important for transactivation of BFV promoters and therefore have an important role in BFV replication.	Lysine	47-54	E1A binding protein p300	Homo sapiens	31-35
9558075-5	1998	An arginine or lysine residue frequently appeared at position alpha93 in the CDR3 of the TCR alpha-chains from Hom-CTL restricted by HLA-A68 or -B8.	Lysine	15-21	T cell receptor alpha constant	Homo sapiens	89-98
21768522-1	2011	Gain-of-function mutations in the human WNK1 (with-no-lysine[K]1) gene are responsible for a monogenic form of arterial hypertension, and WNK1 polymorphisms have been associated with common essential hypertension.	Lysine	54-60	WNK lysine deficient protein kinase 1	Homo sapiens	40-44
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	34-37	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	34-37	parathyroid hormone like hormone	Homo sapiens	214-219
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	46-49	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Lysine	46-49	parathyroid hormone like hormone	Homo sapiens	214-219
16077202-0	2005	Dissimilar effects of LY 294002 and PD 098059 in IGF-I-mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells.	Lysine	22-24	transforming growth factor beta 1	Bos taurus	78-87
9560434-12	1998	The LYS2 mRNA and alpha-aminoadipate reductase activity were repressed to a higher level in YEPD-grown cells than in cells grown in the presence of lysine or minimal medium.	Lysine	148-154	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	4-8
21945770-0	2011	[CpG array analysis of histone H3 lysine 4 trimethylation in patients with IgA nephropathy].	Lysine	34-40	IGAN1	Homo sapiens	75-90
9622212-4	1998	Analysis of his factor X gene revealed a single point mutation within exon II resulting in the substitution of +25 Gla (GAA) by Lys (AAA).	Lysine	128-131	alpha glucosidase	Homo sapiens	120-123
15923642-2	2005	Cellular exposure to ionizing radiation (IR) enhances hMOF-dependent acetylation of its target substrate, lysine 16 (K16) of histone H4 independently of ATM function.	Lysine	106-112	lysine acetyltransferase 8	Homo sapiens	54-58
21945770-1	2011	OBJECTIVE: To investigate the aberrance of histone H3 lysine 4 trimethylation (H3K4me3) in patients with IgA nephropathy (IgAN).	Lysine	54-60	IGAN1	Homo sapiens	105-120
21945770-1	2011	OBJECTIVE: To investigate the aberrance of histone H3 lysine 4 trimethylation (H3K4me3) in patients with IgA nephropathy (IgAN).	Lysine	54-60	IGAN1	Homo sapiens	122-126
15749714-1	2005	Human Ubc13 and Mms2 (or its homolog, Uev1) form a unique ubiquitin-conjugating enzyme (Ubc) complex that generates atypical Lys(63)-linked ubiquitin conjugates.	Lysine	125-128	ubiquitin C	Homo sapiens	58-86
21788362-3	2011	In addition both enzymes play a role in the breakdown of cellular carbon storage reserves with isovaleryl-CoA dehydrogenase being involved in degradation of the branched-chain amino acids, phytol, and lysine while 2-hydroxyglutarate dehydrogenase is exclusively involved in lysine degradation.	Lysine	201-207	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	95-123
15749714-1	2005	Human Ubc13 and Mms2 (or its homolog, Uev1) form a unique ubiquitin-conjugating enzyme (Ubc) complex that generates atypical Lys(63)-linked ubiquitin conjugates.	Lysine	125-128	ubiquitin C	Homo sapiens	6-9
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	suppressor of cytokine signaling 3	Homo sapiens	99-104
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	suppressor of cytokine signaling 3	Homo sapiens	125-130
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	12-15	suppressor of cytokine signaling 3	Homo sapiens	125-130
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	suppressor of cytokine signaling 3	Homo sapiens	99-104
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	suppressor of cytokine signaling 3	Homo sapiens	125-130
9478981-0	1998	Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.	Lysine	142-148	elongation factor for RNA polymerase II	Homo sapiens	26-29
9452937-0	1998	Locomotor and antidepressant-like effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed rats.	Lysine	62-64	5-hydroxytryptamine receptor 1A	Rattus norvegicus	45-52
15554904-7	2005	Mutation of Lys-483, a potential target for Sp3 acetylation, inhibited Sp3-mediated enhancement of SOCS3 mRNA expression and SOCS3 promoter activation, indicating that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression.	Lysine	192-198	suppressor of cytokine signaling 3	Homo sapiens	125-130
21788362-3	2011	In addition both enzymes play a role in the breakdown of cellular carbon storage reserves with isovaleryl-CoA dehydrogenase being involved in degradation of the branched-chain amino acids, phytol, and lysine while 2-hydroxyglutarate dehydrogenase is exclusively involved in lysine degradation.	Lysine	274-280	isovaleryl-CoA-dehydrogenase	Arabidopsis thaliana	95-123
21274613-7	2011	Together, these results suggest that Lys residues might play important roles in regulating the intracellular dynamics of the PRTB protein.	Lysine	37-40	DAZ associated protein 2	Homo sapiens	125-129
15872364-3	2005	METHODS: We designed a series of novel DOTA-alpha-MSH analogs differing from DOTA-NAPamide by small alterations, such as the position of DOTA in the peptide, hydrophobicity, and charge, by modifying the C-terminal Lys(11) residue.	Lysine	214-217	pro-opiomelanocortin-alpha	Mus musculus	44-53
15872364-9	2005	CONCLUSION: The kidney uptake of DOTA-alpha-MSH analogs could be considerably reduced, without affecting MC1R affinity, by altering (neutralizing) the charge of the Lys(11) residue.	Lysine	165-168	pro-opiomelanocortin-alpha	Mus musculus	38-47
9762362-4	1998	Indeed, PLC beta 1 differs from the PLC gamma and della isozymes in that it has a long COOH-terminal sequence which contains a cluster of lysine residues that are critical for association with the nucleus.	Lysine	138-144	phospholipase C, beta 1	Mus musculus	8-18
9475737-4	1998	A dominant-negative brm mutation was generated by replacing a conserved lysine in the ATP-binding site of the BRM protein with an arginine.	Lysine	72-78	brahma	Drosophila melanogaster	20-23
9475737-4	1998	A dominant-negative brm mutation was generated by replacing a conserved lysine in the ATP-binding site of the BRM protein with an arginine.	Lysine	72-78	brahma	Drosophila melanogaster	110-113
21656278-5	2011	For histone H3, lysine residues 14 and 23 were particularly important when POB3 activity is compromised.	Lysine	16-22	FACT complex subunit POB3	Saccharomyces cerevisiae S288C	75-79
9436753-5	1998	Tat repressor function also depends on the presence of a lysine at position 41, located within the core of the protein.	Lysine	57-63	tyrosine aminotransferase	Mus musculus	0-3
15708858-7	2005	Mutant PAR(2) lacking intracellular lysine residues (PAR(2)Delta14K/R) was expressed at the plasma membrane and signaled normally but was not ubiquitinated.	Lysine	36-42	F2R like trypsin receptor 1	Homo sapiens	7-13
15708858-7	2005	Mutant PAR(2) lacking intracellular lysine residues (PAR(2)Delta14K/R) was expressed at the plasma membrane and signaled normally but was not ubiquitinated.	Lysine	36-42	F2R like trypsin receptor 1	Homo sapiens	7-12
21515635-7	2011	Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues.	Lysine	248-254	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-111
15695820-10	2005	A three-dimensional simulation between a BmP09 toxin and an mSlo channel shows that the Lys-41 in BmP09 lies at the center of the interface and plugs into the entrance of the channel pore.	Lysine	88-91	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	60-64
21632252-2	2011	Several new findings suggest that this tight coupling between DNA replication and mitosis is in part controlled by cell cycle regulated chromatin modifications, in particular due to the changing activity of lysine methyltransferase PR-Set7/SET8 that is responsible for the monomethylation of histone H4 at lysine 20.	Lysine	207-213	lysine methyltransferase 5A	Homo sapiens	232-239
15590903-10	2005	FSH increased histone H3 acetylation (lysines 9, 14) within the proximal region of the StAR gene promoter and coincubation with EGF blocked this effect.	Lysine	38-45	steroidogenic acute regulatory protein	Homo sapiens	87-91
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	plasminogen	Homo sapiens	43-46
21632252-2	2011	Several new findings suggest that this tight coupling between DNA replication and mitosis is in part controlled by cell cycle regulated chromatin modifications, in particular due to the changing activity of lysine methyltransferase PR-Set7/SET8 that is responsible for the monomethylation of histone H4 at lysine 20.	Lysine	207-213	lysine methyltransferase 5A	Homo sapiens	240-244
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	plasminogen	Homo sapiens	30-37
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	plasminogen	Homo sapiens	61-64
21684259-1	2011	In budding yeast, there are five JmjC domain-containing proteins, Jhd1, Jhd2, Rph1, Ecm5, and Gis1, which have been suggested to directly remove histone lysine methylation via a hydroxylation reaction.	Lysine	153-159	[Histone H3]-lysine-36 demethylase	Saccharomyces cerevisiae S288C	66-70
15632193-0	2005	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.	Lysine	52-58	E1A binding protein p300	Homo sapiens	38-42
21684259-1	2011	In budding yeast, there are five JmjC domain-containing proteins, Jhd1, Jhd2, Rph1, Ecm5, and Gis1, which have been suggested to directly remove histone lysine methylation via a hydroxylation reaction.	Lysine	153-159	Rph1p	Saccharomyces cerevisiae S288C	78-82
21684259-1	2011	In budding yeast, there are five JmjC domain-containing proteins, Jhd1, Jhd2, Rph1, Ecm5, and Gis1, which have been suggested to directly remove histone lysine methylation via a hydroxylation reaction.	Lysine	153-159	Ecm5p	Saccharomyces cerevisiae S288C	84-88
21652636-5	2011	We demonstrate that lysine 171 of pVHL is important for the final step of cytokinesis: the midbody abscission.	Lysine	20-26	von Hippel-Lindau tumor suppressor	Homo sapiens	34-38
15743275-7	2005	However, whereas increased L-arginine transport is reversed completely by the CAT-1 inhibitor, L-lysine, increased NO release is unaltered, suggesting that NO production in this in vitro model is independent of CAT-1-mediated transport.	Lysine	95-103	solute carrier family 7 member 1	Bos taurus	78-83
15745743-1	2005	Tissue transglutaminase (TGase) is a Ca(2+)-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues.	Lysine	192-195	transglutaminase 1	Homo sapiens	25-30
15743189-1	2005	A cyclic analogue, [cyclo(87-99)MBP(87)(-)(99)], of the human immunodominant MBP(87)(-)(99) epitope, was designed based on ROESY/NMR distance information and modeling data for linear epitope 87-99, taking into account T-cell (Phe(89), Lys(91), Pro(96)) and HLA (His(88), Phe(90), Ile(93)) contact side-chain information.	Lysine	235-238	myelin basic protein	Homo sapiens	32-35
21453345-3	2011	LHT1 mutants displayed reduced uptake rates of L-Gln, L-Ala, L-Glu and L-Asp but not of L-Arg or L-Lys, while AAP5 mutants were affected in the uptake of L-Arg and L-Lys only.	Lysine	164-169	lysine histidine transporter 1	Arabidopsis thaliana	0-4
15743189-1	2005	A cyclic analogue, [cyclo(87-99)MBP(87)(-)(99)], of the human immunodominant MBP(87)(-)(99) epitope, was designed based on ROESY/NMR distance information and modeling data for linear epitope 87-99, taking into account T-cell (Phe(89), Lys(91), Pro(96)) and HLA (His(88), Phe(90), Ile(93)) contact side-chain information.	Lysine	235-238	myelin basic protein	Homo sapiens	77-80
15632200-1	2005	The I-band region of the giant muscle protein titin contains a large domain enriched for the amino acids proline, glutamate, valine, and lysine and is denoted the PEVK domain.	Lysine	137-143	titin	Homo sapiens	46-51
21670282-0	2011	Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.	Lysine	32-38	transient receptor potential cation channel subfamily C member 3	Homo sapiens	76-116
21463634-2	2011	Conjugation of the ubiquitin-like molecule Nedd8 to a conserved lysine residue on the cullin scaffold is essential for the activity of CRLs.	Lysine	64-70	NEDD8 ubiquitin like modifier	Homo sapiens	43-48
15569683-5	2005	In contrast, another mutant of TDGb (TDGb(KR)) in which the lysine residue targeted for SUMO-1 conjugation is replaced with arginine retained the ability to bind SUMO-1 non-covalently.	Lysine	60-66	small ubiquitin like modifier 1	Homo sapiens	88-94
21309869-2	2011	Here, we demonstrate that the Arabidopsis trithorax-like factor ATX1, which trimethylates histone H3 at lysine 4 (H3K4me3), is involved in dehydration stress signaling in both abscisic acid (ABA)-dependent and ABA-independent pathways.	Lysine	104-110	homolog of anti-oxidant 1	Arabidopsis thaliana	64-68
15681608-0	2005	PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis.	Lysine	44-47	PR/SET domain containing protein 7	Drosophila melanogaster	0-7
15681608-1	2005	The histone methyl transferase PR-Set7 mediates histone H4 Lys 20 methylation, a mark of constitutive and facultative heterochromatin.	Lysine	59-62	PR/SET domain containing protein 7	Drosophila melanogaster	31-38
21476511-6	2011	The results also indicate that this in part may be due to charge repulsion between a lysine residue in bovine chymosin and an arginine residue in the P4 position of camel kappa-casein.	Lysine	85-91	chymosin	Bos taurus	110-118
15650876-5	2005	KLRI2 has no ITIM, but a positively charged lysine residue in the transmembrane region, suggesting association with activating adapter molecules.	Lysine	44-50	killer cell lectin-like receptor family I member 2	Rattus norvegicus	0-5
15723809-4	2005	Remarkably, the cyclized lysine branch of the peptide moiety lies in the shallow F" pocket in a conformation that closely mimics that of the alkyl chain in the CD1a-sulfatide structure.	Lysine	25-31	CD1a molecule	Homo sapiens	160-164
21527249-3	2011	Here we show that SAFB1 is modified by both the SUMO1 and SUMO2/3 family of proteins, on lysine"s K231 and K294.	Lysine	89-95	scaffold attachment factor B	Homo sapiens	18-23
15647753-6	2005	Our findings indicate that one of the two chromodomains of Chd1 specifically interacts with the methylated lysine 4 mark on histone H3 that is associated with transcriptional activity.	Lysine	107-113	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	59-63
15519996-1	2005	Previously we used mass spectrometry to show that the yeast G protein alpha subunit Gpa1 is ubiquitinated at Lys-165, located within a subdomain not present in other G alpha proteins (Marotti, L. A., Jr., Newitt, R., Wang, Y., Aebersold, R., and Dohlman, H. G. (2002) Biochemistry 41, 5067-5074).	Lysine	109-112	guanine nucleotide-binding protein subunit alpha	Saccharomyces cerevisiae S288C	84-88
21527249-3	2011	Here we show that SAFB1 is modified by both the SUMO1 and SUMO2/3 family of proteins, on lysine"s K231 and K294.	Lysine	89-95	small ubiquitin like modifier 1	Homo sapiens	48-53
21527717-0	2011	Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.	Lysine	112-115	B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2	Caenorhabditis elegans	63-68
21228036-4	2011	RESULTS: Significantly higher levels of Enhancer of zeste homolog 2 and RING1 and YY1 binding protein transcripts with enhanced levels of trimethylation of lysine 27 on histone H3 were found in adult T-cell leukemia/lymphoma cells compared with those in normal CD4(+) T cells.	Lysine	156-162	ring finger protein 1	Homo sapiens	72-77
15656592-3	2005	Previous studies showed that it is possible to extend the circulating half-life of IFN-alpha2 by modifying lysine residues of the protein with amine-reactive poly(ethylene glycol) (PEG) reagents.	Lysine	107-113	interferon alpha 2	Homo sapiens	83-93
15656592-4	2005	However, amine-PEGylated IFN-alpha2 comprises a heterogeneous product mixture with low specific activity due to the large number and critical locations of lysine residues in IFN-alpha2.	Lysine	155-161	interferon alpha 2	Homo sapiens	25-35
15656592-4	2005	However, amine-PEGylated IFN-alpha2 comprises a heterogeneous product mixture with low specific activity due to the large number and critical locations of lysine residues in IFN-alpha2.	Lysine	155-161	interferon alpha 2	Homo sapiens	174-184
21411292-0	2011	A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-beta synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth.	Lysine	50-53	nucleotide binding oligomerization domain containing 2	Homo sapiens	12-16
15574370-8	2005	The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of tPA-dependent plasmin production.	Lysine	22-29	plasminogen	Homo sapiens	54-61
21411292-1	2011	BACKGROUND: A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18), mimics the bacterial peptidoglycan moiety and acts as a powerful adjuvant that induces cell-mediated immunity.	Lysine	62-65	nucleotide binding oligomerization domain containing 2	Homo sapiens	24-28
15768559-0	2005	Thalassemia intermedia associated with complex interaction of Hb Beijing [alpha16(A14)Lys--&gt;Asn] and Hb E [beta26(B8)Glu--&gt;Lys] with a deletional alpha-thalassemia-1 in a Thai family.	Lysine	129-132	hemoglobin subunit epsilon 1	Homo sapiens	104-108
21325411-3	2011	We show that alteration between a rare lysine and a common N-linked glycan at position 160 of HIV-1 gp120 is primarily responsible for toggling between 2909 and PG16/PG9 neutralization sensitivity.	Lysine	39-45	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	100-105
15921168-4	2005	Direct DNA sequence analysis of selectively amplified segments of the alpha1 and alpha2 genes showed that codon 7 of the alpha2-globin gene was heterozygous for AAG (Lys) and GAG (Glu).	Lysine	166-169	hemoglobin subunit alpha 2	Homo sapiens	121-134
21423168-8	2011	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	Lysine	114-120	homeobox A cluster	Homo sapiens	89-93
15613319-7	2005	Of the two lysine residues in p6, lysine 27 uniquely served as a site of covalent SUMO-1 attachment.	Lysine	11-17	small ubiquitin like modifier 1	Homo sapiens	82-88
15613319-7	2005	Of the two lysine residues in p6, lysine 27 uniquely served as a site of covalent SUMO-1 attachment.	Lysine	34-40	small ubiquitin like modifier 1	Homo sapiens	82-88
21188584-11	2011	Molecular models show PGN-S-monomer inserts its N -acetyl-glucosamine (NAG) deep in the TLR-2 coil, while its terminal lysine interacts with inside (Glu(403)) and outside pocket (Tyr(378)).	Lysine	119-125	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	22-25
15694128-1	2005	Lysyl hydroxylases 1, 2, and 3 catalyse the hydroxylation of specific lysines in collagen.	Lysine	70-77	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-30
21188584-16	2011	MTP, MDP, and lysine-less PGN bind to TLR-2, 87-113.	Lysine	14-20	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	26-29
15694128-8	2005	As these alternate transcripts of LH2 may have specificity for hydroxylation of lysines in either telopeptide or helical collagen domains, their relative expression determines the type of cross-links formed, thereby affecting collagen strength.	Lysine	80-87	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	34-37
21130870-0	2011	TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-kappaB activation.	Lysine	5-8	mitogen-activated protein kinase kinase kinase 7	Mus musculus	0-4
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	mitogen-activated protein kinase kinase kinase 7	Mus musculus	20-24
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	mitogen-activated protein kinase kinase kinase 7	Mus musculus	101-105
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	mitogen-activated protein kinase 14	Mus musculus	157-160
21195142-2	2011	PRC2 trimethylates histone H3 at Lysine 27 and this H3K27me3 epigenetic mark serves as a docking site for the PRC1 protein complex.	Lysine	33-39	protein regulator of cytokinesis 1a	Danio rerio	110-114
16275321-1	2005	The small ubiquitin-like modifier (SUMO) can be conjugated to lysine residues directly by the ubiquitin-conjugating protein Ubc9.	Lysine	62-68	ubiquitin conjugating enzyme E2 I	Homo sapiens	124-128
9885405-10	1998	Our studies (1) show that rhINV(1-585) is a substrate for both TG1 and TG2, (2) indicate that rhINV(1-585) can be cross-linked to form macromolecular products having distinct structural features, (3) demonstrate that rhINV(1-585) forms intramolecular cross-links when hINV concentration is limiting and (4) establish that hINV possesses reactive Gln and Lys residues.	Lysine	354-357	inversin	Homo sapiens	27-31
21392187-8	2011	Exogenously introduced lysine-less TfR, compared to the wild-type one, showed resistance to the iron-induced ubiquitylation and degradation, when endogenous TfR, which most certainly heterodimerizes with exogenous ones, was depleted with siRNA.	Lysine	23-29	transferrin receptor	Homo sapiens	35-38
9885405-10	1998	Our studies (1) show that rhINV(1-585) is a substrate for both TG1 and TG2, (2) indicate that rhINV(1-585) can be cross-linked to form macromolecular products having distinct structural features, (3) demonstrate that rhINV(1-585) forms intramolecular cross-links when hINV concentration is limiting and (4) establish that hINV possesses reactive Gln and Lys residues.	Lysine	354-357	inversin	Homo sapiens	95-99
9391137-0	1997	Us9, a stable lysine-less herpes simplex virus 1 protein, is ubiquitinated before packaging into virions and associates with proteasomes.	Lysine	14-20	membrane protein US9	Human alphaherpesvirus 1	0-3
9391137-4	1997	We conclude that US9 is a lysine-less, ubiquitinated protein that interacts with the ubiquitin-dependent pathway for degradation of proteins and that this function may be initiated at the time of entry of the virus into the cell.	Lysine	26-32	membrane protein US9	Human alphaherpesvirus 1	17-20
16005029-4	2005	The group I non-selective agonist 3,5-DHPG induced a membrane depolarization/inward current that was prevented by co-application of LY 367385, a selective mGluR1 antagonist, and SIB 1757 or MPEP, blockers of mGluR5 subtype.	Lysine	132-134	glutamate metabotropic receptor 1	Homo sapiens	155-161
16005029-4	2005	The group I non-selective agonist 3,5-DHPG induced a membrane depolarization/inward current that was prevented by co-application of LY 367385, a selective mGluR1 antagonist, and SIB 1757 or MPEP, blockers of mGluR5 subtype.	Lysine	132-134	glutamate receptor, ionotropic, kainate 1	Mus musculus	208-214
16005029-7	2005	Interestingly, in the presence of the mGluR5 blocker, SIB 1757, this event was not observed, whereas it occurred in LY 367385.	Lysine	116-118	glutamate receptor, ionotropic, kainate 1	Mus musculus	38-44
21392187-8	2011	Exogenously introduced lysine-less TfR, compared to the wild-type one, showed resistance to the iron-induced ubiquitylation and degradation, when endogenous TfR, which most certainly heterodimerizes with exogenous ones, was depleted with siRNA.	Lysine	23-29	transferrin receptor	Homo sapiens	157-160
21239497-6	2011	In addition, we show that human ASH1L specifically methylates histone H3 Lys-36.	Lysine	73-76	ASH1 like histone lysine methyltransferase	Homo sapiens	32-37
15935836-1	2005	Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin.	Lysine	157-163	carboxypeptidase B2	Homo sapiens	0-43
15935836-1	2005	Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin.	Lysine	157-163	carboxypeptidase B2	Homo sapiens	45-49
9398350-2	1997	0K-beta2 has the following modifications: (1) all 16 lysines in the wild-type beta2 receptor were mutated to arginines, (2) a FLAG epitope preceded by a cleaved hemagglutinin signal sequence was fused to the amino terminus, and (3) a hexahistidine tail was added to the carboxyl terminus.	Lysine	53-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	3-8
21368835-4	2011	It has been proposed that the MSL complex regulates transcriptional elongation to control dosage compensation, a model subsequently supported by mapping of the MSL complex and MSL-dependent histone 4 lysine 16 acetylation to the bodies of X-linked genes in males, with a bias towards 3" ends.	Lysine	200-206	male-specific lethal 3	Drosophila melanogaster	30-33
9398176-0	1997	An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor.	Lysine	72-78	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	116-129
9398176-3	1997	Earlier experiments showing that REDL but not REDLK binds to the KDEL receptor suggested that the terminal lysine is removed sometime during the intoxication process.	Lysine	107-113	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	65-78
15650327-6	2004	These results indicate that lysine 357 is essential for catalytic function, and is involved in binding PLP at the active site.	Lysine	28-34	pyridoxal phosphatase	Homo sapiens	103-106
21368835-4	2011	It has been proposed that the MSL complex regulates transcriptional elongation to control dosage compensation, a model subsequently supported by mapping of the MSL complex and MSL-dependent histone 4 lysine 16 acetylation to the bodies of X-linked genes in males, with a bias towards 3" ends.	Lysine	200-206	male-specific lethal 3	Drosophila melanogaster	160-163
21368835-4	2011	It has been proposed that the MSL complex regulates transcriptional elongation to control dosage compensation, a model subsequently supported by mapping of the MSL complex and MSL-dependent histone 4 lysine 16 acetylation to the bodies of X-linked genes in males, with a bias towards 3" ends.	Lysine	200-206	male-specific lethal 3	Drosophila melanogaster	160-163
15375179-2	2004	We previously reported that a lysine-rich, alpha-helical peptide spanning human apoB amino acids 4372-4392 was an effective inhibitor of Lp(a) assembly in vitro.	Lysine	30-36	lipoprotein(a)	Homo sapiens	137-142
20885444-0	2011	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.	Lysine	28-34	BCL2-like 1	Mus musculus	70-76
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	149-152	death domain associated protein	Homo sapiens	41-45
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Lysine	185-188	death domain associated protein	Homo sapiens	41-45
15546623-0	2004	Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes.	Lysine	37-43	Polycomb	Drosophila melanogaster	96-104
9368059-1	1997	When rat liver xanthine dehydrogenase was incubated with fluorodinitrobenzene (FDNB) at pH 8.5, the total enzyme activity decreased gradually to a limited value of initial activity with modification of two lysine residues in a similar way to the modification of bovine milk xanthine oxidase with FDNB (Nishino, T., Tsushima, K., Hille, R. and Massey, V. (1982) J. Biol.	Lysine	206-212	xanthine dehydrogenase	Rattus norvegicus	15-37
9368059-5	1997	During the modification of these lysine residues, xanthine dehydrogenase was found to be converted to an oxidase form in the early stage of incubation.	Lysine	33-39	xanthine dehydrogenase	Rattus norvegicus	50-72
9520126-3	1997	Apolipoprotein(a) contains a major lysine-binding site in one of its kringle domains.	Lysine	35-41	lipoprotein(a)	Homo sapiens	0-17
9520126-4	1997	Destroying this site by site-directed mutagenesis greatly reduces the binding of apolipoprotein(a) to lysine and fibrin.	Lysine	102-108	lipoprotein(a)	Homo sapiens	81-98
20885444-6	2011	To gain insight into the mechanism of Bax-Kv1.3 interaction, we mutated Glu158 of Bcl-x(L) (corresponding to K128 in Bax) to lysine.	Lysine	125-131	BCL2-like 1	Mus musculus	82-90
9399582-5	1997	The order of Kcat/Km values of AAP at optimal pH (pH 7.5) was Ala- &gt; Lys-Ala- &gt; or = Met- &gt; Leu- &gt; Phe- &gt; Arg- &gt; or = Arg-Arg- &gt; Lys- &gt; Gly-MCAs.	Lysine	72-75	alanyl aminopeptidase, membrane	Homo sapiens	31-34
20865325-1	2011	Transglutaminase (TGase) is a family of enzymes that catalyzes cross-linking reaction between glutamine- and lysine residue of substrate proteins in several mammalian biological events.	Lysine	109-115	transglutaminase 1	Homo sapiens	0-16
9399582-5	1997	The order of Kcat/Km values of AAP at optimal pH (pH 7.5) was Ala- &gt; Lys-Ala- &gt; or = Met- &gt; Leu- &gt; Phe- &gt; Arg- &gt; or = Arg-Arg- &gt; Lys- &gt; Gly-MCAs.	Lysine	150-153	alanyl aminopeptidase, membrane	Homo sapiens	31-34
9399586-7	1997	In addition, we showed that both S-MBP and L-MBP undergo hydroxylation of lysine and proline residues in collagen-like sequences, and that the hydroxylysine is glycosylated to form glucosylgalactosylhydroxylysine (GluGalHyl) and galactosylhydroxylysine (GalHyl).	Lysine	74-80	myelin basic protein	Homo sapiens	35-38
9399586-7	1997	In addition, we showed that both S-MBP and L-MBP undergo hydroxylation of lysine and proline residues in collagen-like sequences, and that the hydroxylysine is glycosylated to form glucosylgalactosylhydroxylysine (GluGalHyl) and galactosylhydroxylysine (GalHyl).	Lysine	74-80	myelin basic protein	Homo sapiens	45-48
9307016-6	1997	Amino acid analysis showed that the amino acid composition of DNase gamma was similar to that of rat DNase I (molecular mass 32 kDa) but different with regard to alanine and lysine residues.	Lysine	174-180	deoxyribonuclease 1-like 3	Rattus norvegicus	62-73
15546623-2	2004	Here we investigate the relationship between Polycomb binding, transcriptional status, and histone H3 methylation at lysine 9 (H3K9Me) and 27 (H3K27Me) for over 30 PcG targets in Drosophila.	Lysine	117-123	Polycomb	Drosophila melanogaster	45-53
15507486-1	2004	Parts of the PEVK (Pro-Glu-Val-Lys) domain of the skeletal muscle isoform of the giant intrasarcomeric protein titin have been shown to bind F-actin.	Lysine	31-34	titin	Homo sapiens	111-116
15326176-7	2004	Orthovanadate-trapping experiments showed that mutation to Gln, Ala, Asp, or Lys altered characteristics of the transition state but did not eliminate its formation in contrast e.g. with mutation of the analogous catalytic Glu in F1-ATPase.	Lysine	77-80	dynein, axonemal, heavy chain 8	Mus musculus	233-239
20865325-1	2011	Transglutaminase (TGase) is a family of enzymes that catalyzes cross-linking reaction between glutamine- and lysine residue of substrate proteins in several mammalian biological events.	Lysine	109-115	transglutaminase 1	Homo sapiens	18-23
21123178-7	2011	Conserved lysine residues in the distal alpha-helix of the double-stranded RNA-binding domains are necessary to engage structural features of retroviral and junD 5"-UTRs.	Lysine	10-16	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-161
15646642-7	2004	Interferon alpha-2a is monopegylated at four major positional lysine (Lys) residues.	Lysine	62-68	interferon alpha 2	Homo sapiens	0-19
15646642-7	2004	Interferon alpha-2a is monopegylated at four major positional lysine (Lys) residues.	Lysine	70-73	interferon alpha 2	Homo sapiens	0-19
15546195-1	2004	The cDNA encoding human cystatin C (HCC) was subjected to site-specific substitution of alanine for serine at the position 37, to obtain the Asn(35)-Lys(36)-Ser(37) sequence that is a signal for asparagine-linked (N-linked) glycosylation of protein in eukaryotes, and was transformed into Pichia pastoris X33.	Lysine	149-152	cystatin C	Homo sapiens	24-34
15546210-7	2004	The uptake in the pancreas could be blocked by BN (11.96 +/- 1.17 vs 0.65 +/- 0.16% ID/g), partially blocked by neuromedin B (11.96 +/- 1.17 vs 6.66 +/- 0.51% ID/g), but not affected by somatostatin (11.96 +/- 1.17 vs 12.91 +/- 2.53% ID/g), indicating that the binding of [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN to the receptors was specific.	Lysine	282-285	neuromedin B	Homo sapiens	112-124
9235940-11	1997	We conclude that selected lysine and arginine residues on the surface of DNase I constitute the major elements of the phosphotransferase recognition domain present on this secretory glycoprotein.	Lysine	26-32	deoxyribonuclease 1	Bos taurus	73-80
21177250-0	2011	HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity.	Lysine	27-33	histone deacetylase 3	Homo sapiens	0-5
9444977-4	1997	Coimmunization with Ac1-11 and Ac1-11[4A], an analog in which lysine at position four is substituted with alanine, prevents EAE.	Lysine	62-68	adenylate cyclase 1	Mus musculus	20-23
9444977-4	1997	Coimmunization with Ac1-11 and Ac1-11[4A], an analog in which lysine at position four is substituted with alanine, prevents EAE.	Lysine	62-68	adenylate cyclase 1	Mus musculus	31-34
15560799-3	2004	MALDI-TOF MS revealed that T800 contains the entire titin PEVK (Pro, Glu, Val, Lys-rich) domain.	Lysine	79-82	titin	Homo sapiens	52-57
21386137-4	2011	It has recently been shown that MnSOD enzymatic activity is regulated by the reversible acetylation of specific, evolutionarily conserved lysine(s) in the protein.	Lysine	138-144	superoxide dismutase 2	Homo sapiens	32-37
15507114-3	2004	We have found PPARgamma2 and its isoform, PPARgamma1, to be modified by small ubiquitin-related modifier (SUMO)-1 in vivo, at a lysine residue in the repression domain.	Lysine	128-134	peroxisome proliferator activated receptor gamma	Mus musculus	14-24
9245707-4	1997	Recombinant murine angiostatin was purified from the culture medium of angiostatin baculovirus-infected insect cells (yield = 1 mg/liter) with a single-step of lysine-Sepharose chromatography.	Lysine	160-166	plasminogen	Mus musculus	19-30
9361968-9	1997	The protein products of the DPB1*0201 and 0402 alleles differ by a single amino acid at position 69 (DPB1*0402--Lysine, DPB1*0201--glutamic acid).	Lysine	112-118	major histocompatibility complex, class II, DP beta 1	Homo sapiens	28-32
9361968-9	1997	The protein products of the DPB1*0201 and 0402 alleles differ by a single amino acid at position 69 (DPB1*0402--Lysine, DPB1*0201--glutamic acid).	Lysine	112-118	major histocompatibility complex, class II, DP beta 1	Homo sapiens	101-105
9361968-9	1997	The protein products of the DPB1*0201 and 0402 alleles differ by a single amino acid at position 69 (DPB1*0402--Lysine, DPB1*0201--glutamic acid).	Lysine	112-118	major histocompatibility complex, class II, DP beta 1	Homo sapiens	101-105
9361968-13	1997	However the amino acid difference at position 69 does not explain all responses due to DP in the MLR-1 as evidenced by the strong responses observed in cases where DPB1*0301 (lysine pos.)	Lysine	175-181	major histocompatibility complex, class II, DP beta 1	Homo sapiens	164-168
21386137-5	2011	These results, suggest for the first time, that the mitochondria contain bidirectional post-translational signaling networks, similar to that observed in the cytoplasm and nucleus, and that changes in lysine acetylation alter MnSOD enzymatic activity.	Lysine	201-207	superoxide dismutase 2	Homo sapiens	226-231
20872871-7	2011	The P37-metal interaction is drove by positively charged fragments of selected amino acids,mainly threonine 109, lysine 122, and arginine in positions 114 and 133.	Lysine	113-119	nucleoporin 37	Homo sapiens	4-7
9207182-3	1997	However, six invariant amino acids such as a lysine in the ATP-binding site and an aspartic acid in the phosphotransfer site of a conserved catalytic domain were substituted with other amino acid residues in HEP.	Lysine	45-51	EPH receptor B6	Homo sapiens	208-211
15536609-5	2004	The HPRT cDNA sequence revealed a point mutation of G to A in nucleotide 40, which changed codon 14 from GAA (Glu) to AAA (Lys) in the mutant gene.	Lysine	123-126	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	4-8
20798689-4	2011	The lysine residue, K33, of cyclin D1 is a key site for this newly identified regulation.	Lysine	4-10	cyclin D1	Homo sapiens	28-37
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	complement C4B (Chido blood group)	Homo sapiens	87-90
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	complement C4B (Chido blood group)	Homo sapiens	87-90
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	complement C4B (Chido blood group)	Homo sapiens	87-90
9192782-6	1997	The plasmin-induced chemotactic response was inhibited by the lysine analog trans-4-(aminomethyl)cyclohexane-1-carboxylic acid (t-AMCA), which prevents binding of plasmin/ogen to the appropriate membrane binding sites.	Lysine	62-68	plasminogen	Homo sapiens	4-11
9192782-6	1997	The plasmin-induced chemotactic response was inhibited by the lysine analog trans-4-(aminomethyl)cyclohexane-1-carboxylic acid (t-AMCA), which prevents binding of plasmin/ogen to the appropriate membrane binding sites.	Lysine	62-68	plasminogen	Homo sapiens	163-170
21276944-5	2011	One lysine in the MINT protein is dimethylated in vitro and in vivo demonstrating that the product pattern created by SET7/9 depends on the amino acid sequence context of the target site.	Lysine	4-10	spen family transcriptional repressor	Homo sapiens	18-22
9166404-9	1997	A mutant Lck molecule in which the palmitoylation site at cysteine 5 was changed to lysine (LC2) localized to the plasma membrane and the Golgi region in NIH3T3 cells.	Lysine	84-90	lymphocyte protein tyrosine kinase	Mus musculus	9-12
9166404-9	1997	A mutant Lck molecule in which the palmitoylation site at cysteine 5 was changed to lysine (LC2) localized to the plasma membrane and the Golgi region in NIH3T3 cells.	Lysine	84-90	dynein light chain Tctex-type 2A1	Mus musculus	92-95
15494452-1	2004	The present results demonstrate that pyridoxal, pyridoxal 5"-phosphate (PLP) and pyridoxal 5"-diphospho-5"-adenosine (PLP-AMP) inhibit Candida guilliermondii and human DNA topoisomerases I in forming an aldimine with the epsilon-amino group of an active site lysine.	Lysine	259-265	pyridoxal phosphatase	Homo sapiens	72-75
15494452-1	2004	The present results demonstrate that pyridoxal, pyridoxal 5"-phosphate (PLP) and pyridoxal 5"-diphospho-5"-adenosine (PLP-AMP) inhibit Candida guilliermondii and human DNA topoisomerases I in forming an aldimine with the epsilon-amino group of an active site lysine.	Lysine	259-265	pyridoxal phosphatase	Homo sapiens	118-121
15494452-4	2004	The limited trypsic proteolysis releases a 17 residue peptide bearing a lysine-bound PLP (KPPNTVIFDFLGK*DSIR).	Lysine	72-78	pyridoxal phosphatase	Homo sapiens	85-88
9166423-8	1997	The rank order of the dissociation constant for the different GMR-alphaR280 mutations where Lys &gt; Gln &gt; Met &gt; Asp, suggesting the importance of the charge at this position.	Lysine	92-95	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	62-65
21304913-1	2011	Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18.	Lysine	65-71	RAD18 E3 ubiquitin protein ligase	Mus musculus	192-197
9366186-5	1997	Molecular analysis identified a missense mutation, a glutamate (174)-to-lysine substitution (E174K), in the CPT II cDNA.	Lysine	72-78	carnitine palmitoyltransferase 2	Homo sapiens	108-114
15121739-5	2004	FGF-1-induced PN expression was blocked by the FGF-1 receptor antagonist PD-166866 and by inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY-294002, wortmannin), p70S6K (rapamycin), MEK1/2 (U-0126, PD-98059), and p38MAPK (SB-203580) but not of JNK (SP-600125).	Lysine	142-144	mitogen activated protein kinase kinase 1	Rattus norvegicus	186-192
21248752-4	2011	These genes encode enzymes that demethylate (UTX, JARID1C) or methylate (SETD2) key lysine residues of histone H3.	Lysine	84-90	lysine demethylase 5C	Homo sapiens	50-57
15293224-4	2004	Here, we demonstrate that p34(cdc2) kinase activity and protein synthesis are responsible for the activation of histone deacetylases and the inhibition of histone acetyltransferases (HATs), respectively, resulting in deacetylation of histone H4 at lysine-12 (H4K12) during mouse oocyte meiosis.	Lysine	248-254	cyclin-dependent kinase 1	Mus musculus	30-34
9179853-4	1997	An in vivo isolated mutation (gap1pgr) causes a single Glu--&gt;Lys substitution in an amino acid context similar to the DXKSS sequence involved in ubiquitination and endocytosis of the yeast alpha-factor receptor, Ste2p.	Lysine	64-67	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	215-220
21248752-4	2011	These genes encode enzymes that demethylate (UTX, JARID1C) or methylate (SETD2) key lysine residues of histone H3.	Lysine	84-90	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	73-78
15543946-6	2004	We generated a series of charge-based substitution mutations at position 1113 and found that conversion of arginine 1113 to glutamic acid, alanine, or lysine prevented Jak2 autophosphorylation.	Lysine	151-157	Janus kinase 2	Homo sapiens	168-172
9184408-5	1997	The functional and clinical significance of this polymorphism was analysed in a case-control study and by comparing the in vitro lysine binding characteristics of the two Lp(a) subtypes.	Lysine	129-135	lipoprotein(a)	Homo sapiens	171-176
20837137-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with TAK1 wild-type, K158R mutant, or K34R mutant reveals that TAK1 lysine 158 residue is required for TGF-beta-induced IKK, p38 and JNK activation.	Lysine	131-137	mitogen-activated protein kinase kinase kinase 7	Mus musculus	18-22
20837137-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with TAK1 wild-type, K158R mutant, or K34R mutant reveals that TAK1 lysine 158 residue is required for TGF-beta-induced IKK, p38 and JNK activation.	Lysine	131-137	mitogen-activated protein kinase kinase kinase 7	Mus musculus	68-72
20837137-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with TAK1 wild-type, K158R mutant, or K34R mutant reveals that TAK1 lysine 158 residue is required for TGF-beta-induced IKK, p38 and JNK activation.	Lysine	131-137	transforming growth factor, beta 1	Mus musculus	166-174
20837137-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with TAK1 wild-type, K158R mutant, or K34R mutant reveals that TAK1 lysine 158 residue is required for TGF-beta-induced IKK, p38 and JNK activation.	Lysine	131-137	mitogen-activated protein kinase 14	Mus musculus	188-191
9141666-3	1997	Exchanging Phe-19 for Ser and Glu-16 for Lys in the FDLEI-motif, reduced Pep5 production to 35 and 38% of the control whereas, after exchanging Asp-6 for Ser and Glu-16 for Lys in the FDLEI-motif, reduced Pep5 production to 35 and 38% of the control whereas, after exchanging ASp-6 for Lys, the production was decreased only to 82%.	Lysine	41-44	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	73-77
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Lysine	228-234	Jun dimerization protein 2	Mus musculus	37-41
9092516-9	1997	Heparin partially protects Ang from cleavage by trypsin at Lys-60, suggesting that heparin also binds to the region of Ang that contains this residue.	Lysine	59-62	angiogenin	Homo sapiens	27-30
15379562-9	2004	Differential binding kinetics between Glu(1)-/Lys(78)-plasminogen and apo(a) may explain why Lp(a) is a stronger inhibitor of tPA-mediated Glu(1)-plasminogen activation compared to Lys(78)-plasminogen activation.	Lysine	46-49	lipoprotein(a)	Homo sapiens	93-98
21736542-5	2011	Oxygen induces the expression of the JDP2 gene and JDP2 then inhibits the recruitment of polycomb repressive complexes (PRCs1 and 2) to the promoter of the gene encoding p16(Ink4a), resulting in the inhibition of methylation of lysine 27 of histone H3.	Lysine	228-234	Jun dimerization protein 2	Mus musculus	51-55
21647302-0	2011	The DNA binding and bending activities of truncated tail-less HMGB1 protein are differentially affected by Lys-2 and Lys-81 residues and their acetylation.	Lysine	107-110	high mobility group box 1	Homo sapiens	62-67
15210723-5	2004	Lysine produced a stronger growth stimulating effect than glutamic acid consistent with an upregulated expression of the IDP3 gene for peroxisomal synthesis of the glutamate precursor alpha-ketoglutarate.	Lysine	0-6	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	121-125
15313218-3	2004	Further characterization of antioxidant activity of the sugar specific-lysine MRPs in chemical (e.g., hydrophobic (1,1,-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydrophilic (Fenton reaction-induced hydroxyl radical) in vitro scavenging assays showed that Rib-Lys HMW MRPs had the highest (p&lt;0.05) affinity to scavenge free radicals.	Lysine	71-77	cilia and flagella associated protein 97	Homo sapiens	268-271
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Lysine	137-143	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	56-60
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Lysine	250-256	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	56-60
9130734-6	1997	The GnRH antagonist [N-Ac-D-Nal(2)1,D-pCl-Phe2,D-Pal(3)3,D-(Hci)6, Lys(iPr)8,D-Ala10]GnRH (Antarelix) (concentration 10 mg/ml) was administered as three daily s.c. injections, at a dose of 1 mg/kg on days 11, 12 and 13 of the follicular phase of the menstrual cycle.	Lysine	67-70	gonadotropin releasing hormone 1	Homo sapiens	4-8
21647302-1	2011	The role of lysines 2 and 81 as target sites for acetylation in full-length HMGB1 and truncated tail-less protein, respectively, has been studied by mutation analysis for the abilities of these proteins to bind and bend DNA.	Lysine	12-19	high mobility group box 1	Homo sapiens	76-81
21647302-2	2011	The DNA bending ability of truncated tail-less HMGB1 containing Lys-2 mutated to alanine does not differ from that of the wild-type protein, while the same mutation of Lys-81 reduced the bending capacity of the mutant protein.	Lysine	64-67	high mobility group box 1	Homo sapiens	47-52
15192092-3	2004	SF-1 was modified predominantly at Lys(194) and much less at Lys(119) when free SUMO-1 was supplied.	Lysine	61-64	small ubiquitin like modifier 1	Homo sapiens	80-86
21647302-3	2011	These data demonstrate that Lys-81 is critical for the DNA bending ability of truncated HMGB1.	Lysine	28-31	high mobility group box 1	Homo sapiens	88-93
9066781-1	1997	Deoxyhypusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (elF-5A) precursor using spermidine as the substrate.	Lysine	51-57	eukaryotic translation initiation factor 5A2	Homo sapiens	90-121
21647302-5	2011	On the contrary, the acetylation of Lys-81 in the mutant K2/A2 enhanced the bending potential of HMGB1 C. Regarding the ability of HMGB1 to specifically bind bent DNA, the individual mutations of either K2 or K81 as well as the double mutation of both residues to alanine were found to completely abolish binding of truncated tail-less HMGB1 to cisplatin-modified DNA.	Lysine	36-39	high mobility group box 1	Homo sapiens	97-102
21647302-5	2011	On the contrary, the acetylation of Lys-81 in the mutant K2/A2 enhanced the bending potential of HMGB1 C. Regarding the ability of HMGB1 to specifically bind bent DNA, the individual mutations of either K2 or K81 as well as the double mutation of both residues to alanine were found to completely abolish binding of truncated tail-less HMGB1 to cisplatin-modified DNA.	Lysine	36-39	high mobility group box 1	Homo sapiens	131-136
15312251-2	2004	We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.	Lysine	54-60	TNF receptor superfamily member 11b	Homo sapiens	34-43
21647302-5	2011	On the contrary, the acetylation of Lys-81 in the mutant K2/A2 enhanced the bending potential of HMGB1 C. Regarding the ability of HMGB1 to specifically bind bent DNA, the individual mutations of either K2 or K81 as well as the double mutation of both residues to alanine were found to completely abolish binding of truncated tail-less HMGB1 to cisplatin-modified DNA.	Lysine	36-39	high mobility group box 1	Homo sapiens	131-136
15312251-2	2004	We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.	Lysine	54-60	TNF receptor superfamily member 11b	Homo sapiens	79-82
15312251-7	2004	Informative single nucleotide polymorphisms (SNPs), including a G1181C SNP, which predicts a lysine-asparagine substitution at codon 3 of the OPG signal peptide and haplotypes, were related to the presence of PDB in 312 cases compared with 378 controls and to transmission of PDB in 140 affected offspring from 66 kindreds with familial PDB.	Lysine	93-99	TNF receptor superfamily member 11b	Homo sapiens	142-145
15312251-11	2004	We conclude that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to the development of sporadic PDB and familial PDB that is not caused by SQSTM1 mutations.	Lysine	57-63	TNF receptor superfamily member 11b	Homo sapiens	37-46
9059886-6	1997	They are virtually identical to the inhibitory forms in their extracellular portions, but display a short cytoplasmic tail lacking ITIM motifs associated with a Lys-containing transmembrane portion (p50).	Lysine	161-164	CD40 molecule	Homo sapiens	199-202
21647302-6	2011	We conclude that unlike the case with the bending ability of truncated HMGB1, where Lys-81 has a primary function, Lys-2 and Lys-81 are both critical for the protein"s binding to cisplatin-modified DNA.	Lysine	84-87	high mobility group box 1	Homo sapiens	71-76
21647302-6	2011	We conclude that unlike the case with the bending ability of truncated HMGB1, where Lys-81 has a primary function, Lys-2 and Lys-81 are both critical for the protein"s binding to cisplatin-modified DNA.	Lysine	115-118	high mobility group box 1	Homo sapiens	71-76
8977177-3	1997	Cross-linking of alphaL beta2 and alpha4 beta1 on human T lymphocytes (T cell line and peripheral blood T cells) with immobilized mAbs induced motile behavior on fibronectin, laminin, collagen type IV, and poly-L-lysine.	Lysine	206-219	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	24-46
21647302-8	2011	Any further substitutions at the acetylable lysines in the truncated form of HMGB1 do not have an additional effect.	Lysine	44-51	high mobility group box 1	Homo sapiens	77-82
21197464-4	2011	JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27).	Lysine	176-182	Jun dimerization protein 2	Mus musculus	0-4
8972223-5	1997	In the C terminus of the IGF-I receptor, two mutations, one at tyrosine 1251 and one which replaced residues histidine 1293 and lysine 1294, abolished the antiapoptotic function, whereas mutation of the four serines at 1280 to 1283 did not.	Lysine	128-134	insulin-like growth factor 1 receptor	Rattus norvegicus	25-39
15312251-11	2004	We conclude that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to the development of sporadic PDB and familial PDB that is not caused by SQSTM1 mutations.	Lysine	57-63	TNF receptor superfamily member 11b	Homo sapiens	82-85
21674327-1	2011	Transglutaminase (TGase) is an enzyme that catalyzes the post-translational covalent cross-linking of Gln- and Lys-containing peptides and/or proteins according to its substrate specificity.	Lysine	111-114	transglutaminase 1	Homo sapiens	0-16
15137910-6	2004	By using the isolated phage antibodies, we demonstrated for the first time that a lysine residue following the CXXC motif significantly increases the isomerase activities of PDI family proteins.	Lysine	82-88	prolyl 4-hydroxylase subunit beta	Homo sapiens	174-177
8977462-7	1996	We directly demonstrated that the lysine-binding sites (LBSs) within kringle IV types 5-9 are "masked" in the context of the Lp(a) particle and are consequently unavailable for interaction with lysine-Sepharose.	Lysine	34-40	lipoprotein(a)	Homo sapiens	125-130
8977462-9	1996	In summary, the results of our study indicate that apo(a) kringle IV types 7 and 8 are required for maximal efficiency of Lp(a) formation, likely by virtue of their ability to mediate lysine-dependent non-covalent interactions with apoB-100 that precede disulfide bond formation.	Lysine	184-190	lipoprotein(a)	Homo sapiens	122-127
21674327-1	2011	Transglutaminase (TGase) is an enzyme that catalyzes the post-translational covalent cross-linking of Gln- and Lys-containing peptides and/or proteins according to its substrate specificity.	Lysine	111-114	transglutaminase 1	Homo sapiens	18-23
15377272-1	2004	A comparative study of secondary specificities of enteropeptidase and trypsin was performed using peptide substrates with general formula A-(Asp/Glu)n-Lys(Arg)-(downward arrow)-B, where n = 1-4.	Lysine	151-154	transmembrane serine protease 15	Homo sapiens	50-65
21935442-7	2011	An in vitro proteome-derived peptide library Nt-acetylation assay indicated that recombinant hNaa40p acetylates N-termini starting with the consensus sequence Ser-Gly-Gly-Gly-Lys-, strongly resembling the N-termini of the human histones H2A and H4.	Lysine	175-178	H2A clustered histone 18	Homo sapiens	237-247
15259025-5	2004	One of these lysine-containing peptides effectively inhibits VAP-1-dependent lymphocyte rolling and firm adhesion to primary endothelial cells under physiologically relevant shear conditions.	Lysine	13-19	amine oxidase copper containing 3	Homo sapiens	61-66
8946838-5	1996	We previously reported that Tat is a direct angiogenic factor and noted the Tat arginine- and lysine-rich sequence is similar to that of other potent angiogenic growth factors, such as vascular endothelial growth factor-A (VEGF-A).	Lysine	94-100	tyrosine aminotransferase	Homo sapiens	76-79
21935461-9	2011	We observed hyperacetylation together with trimethylation of Lys-4 at the IL-17 locus in TCF-1(-/-) thymocytes, two epigenetic modifications indicating an open active state of the gene.	Lysine	61-64	transcription factor 7, T cell specific	Mus musculus	89-94
8910412-0	1996	Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration.	Lysine	0-6	mannose receptor C-type 1	Homo sapiens	73-89
21887258-3	2011	In our earlier studies, we found that SMYD3 has methyltransferase activity to histone H3 lysine 4, and that its up-regulation is involved in the tumorigenesis of human colon, liver, and breast.	Lysine	89-95	SET and MYND domain containing 3	Homo sapiens	38-43
8824206-1	1996	The lysine residue Lys492 located in the large cytoplasmic domain of sarcoplasmic reticulum Ca2+-ATPase is implicated in nucleotide binding through affinity labeling.	Lysine	4-10	dynein axonemal heavy chain 8	Homo sapiens	97-103
15231023-3	2004	The data indicate that LH2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues.	Lysine	103-109	LIM homeobox protein 9	Mus musculus	23-27
15231023-11	2004	CONCLUSIONS: The data clearly show a critical role of LH2b in determining collagen cross-linking pathways, most likely through its action on telopeptidyl Lys residues.	Lysine	154-157	LIM homeobox protein 9	Mus musculus	54-58
21687692-9	2011	Most of the reactive lysine and glutamine residues in SLPI are located in its first N-terminal elafin-like domain, while in trappin-2, they are located in both the N-terminal cementoin domain and the elafin moiety.	Lysine	21-27	peptidase inhibitor 3	Homo sapiens	95-101
15181151-4	2004	Here, we identify by bioinformatics and mutational analyses three functional domains of the hSlu7 protein that have distinct roles in its subcellular localization: a nuclear localization signal, a zinc-knuckle motif, and a lysine-rich region.	Lysine	223-229	SLU7 homolog, splicing factor	Homo sapiens	92-97
15107423-1	2004	Saccharomyces cerevisiae lacking Cu,Zn superoxide dismutase (SOD1) show several metabolic defects including aerobic blockages in methionine and lysine biosynthesis.	Lysine	144-150	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	61-65
8964456-2	1996	They belong to molecular class A, and differ by one amino acid at position 39:TEM-1 have a glutamine and TEM-2 a lysine.	Lysine	113-119	RASD family member 2	Homo sapiens	105-110
8964456-5	1996	Molecular modelling of TEM-2, when compared to that of TEM-1, showed an additional ionic bond between Lys-39 and Glu-281.	Lysine	102-105	RASD family member 2	Homo sapiens	23-28
20506301-4	2011	Both LY 354,740 and LY 379,268 exhibited potent agonist activity for mGluR2 in the 35S-GTPgammaS assay.	Lysine	5-7	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	69-75
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Lysine	155-161	isocitrate lyase 1	Saccharomyces cerevisiae S288C	36-40
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Lysine	155-161	isocitrate lyase 1	Saccharomyces cerevisiae S288C	173-177
8923733-8	1996	Thus, the results presented in this work argue for ICL2 encoding a non-functional isocitrate lyase and provide evidence that lysine 216 of Icl1 is not essential for catalysis.	Lysine	125-131	isocitrate lyase 1	Saccharomyces cerevisiae S288C	139-143
20506301-4	2011	Both LY 354,740 and LY 379,268 exhibited potent agonist activity for mGluR2 in the 35S-GTPgammaS assay.	Lysine	20-22	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	69-75
20923758-8	2010	Fragmentation of the cross-linked fragment and Ste2p using tandem mass spectrometry pinpointed the cross-link point of the DOPA(1) of the alpha-factor analog to the Ste2p Lys(269) side chain near the extracellular surface of the TM6-TM7 bundle.	Lysine	171-174	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	47-52
8843702-6	1996	Three peptide analogues, in which 7, 11, and 17 were Ala, Cys, or Lys, inhibited about as well as XIP.	Lysine	66-69	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	98-101
15138260-4	2004	The p300-dependent acetylation of three lysine residues protects RUNX3 from ubiquitin ligase Smurf-mediated degradation.	Lysine	40-46	E1A binding protein p300	Homo sapiens	4-8
15497507-4	2004	We found that, similar to its human counterpart, Xenopus Hsf2 is sumoylated at lysine 82 and that, as it does in human Hsf2, the modification event of the small ubiquitin-related modifier 1 functions to increase the deoxyribonucleic acid-binding activity of this transcription factor in Xenopus.	Lysine	79-85	small ubiquitin like modifier 1	Homo sapiens	155-189
20923758-8	2010	Fragmentation of the cross-linked fragment and Ste2p using tandem mass spectrometry pinpointed the cross-link point of the DOPA(1) of the alpha-factor analog to the Ste2p Lys(269) side chain near the extracellular surface of the TM6-TM7 bundle.	Lysine	171-174	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	165-170
20693536-7	2010	Along the H19/Igf2 imprinted domain, allele-specific acetylation at each lysine residue depended on functional CTCF binding sites in the imprinting control region.	Lysine	73-79	CCCTC-binding factor	Mus musculus	111-115
15231737-9	2004	Importantly, recruitment of Suz12, Ezh2 and Eed to target promoters coincides with methylation of histone H3 on Lys 27.	Lysine	112-115	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	28-33
15208638-0	2004	Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.	Lysine	80-83	ubiquitin	Saccharomyces cerevisiae S288C	94-103
15208638-3	2004	Here we show that a single ubiquitin chain is attached to Met4 through lysine at position 163.	Lysine	71-77	ubiquitin	Saccharomyces cerevisiae S288C	27-36
8861938-0	1996	Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.	Lysine	31-37	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	104-108
8861938-5	1996	Changing lysine (K) at position 80 to methionine (M) removed the sensitivity of ROMK1 channels to intracellular pH.	Lysine	9-15	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	80-85
15208638-6	2004	Surprisingly, the ubiquitin chain attached to Met4 is linked through Lys 48 in ubiquitin, a ubiquitin chain structure that is usually required for substrate targeting to the 26S proteasome.	Lysine	69-72	ubiquitin	Saccharomyces cerevisiae S288C	18-27
20870719-5	2010	Furthermore, we show that RB monomethylation at lysine 860 provides a direct binding site for the methyl-binding domain of the transcriptional repressor L3MBTL1.	Lysine	48-54	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	153-160
15208638-6	2004	Surprisingly, the ubiquitin chain attached to Met4 is linked through Lys 48 in ubiquitin, a ubiquitin chain structure that is usually required for substrate targeting to the 26S proteasome.	Lysine	69-72	ubiquitin	Saccharomyces cerevisiae S288C	79-88
15208638-6	2004	Surprisingly, the ubiquitin chain attached to Met4 is linked through Lys 48 in ubiquitin, a ubiquitin chain structure that is usually required for substrate targeting to the 26S proteasome.	Lysine	69-72	ubiquitin	Saccharomyces cerevisiae S288C	79-88
15208638-7	2004	These results suggest that Lys 48-linked ubiquitin chains can have a regulatory role independent of proteolysis.	Lysine	27-30	ubiquitin	Saccharomyces cerevisiae S288C	41-50
8754835-4	1996	By immunoprecipitation of chromatin fragments with antibodies specific for H4 acetylated at particular lysine residues, we found that only three of the four lysine residues in the amino-terminal domain of histone H4 spanning the silent cassettes are hypoacetylated.	Lysine	157-163	histone H4	Saccharomyces cerevisiae S288C	205-215
20933223-2	2010	In a reaction with the lysines of bovine heart cytochrome c, R5P generates superoxide (O2-) that subsequently reduces ferri-cytochrome c to ferro-cytochrome c.	Lysine	23-30	LOC104968582	Bos taurus	47-59
8690792-1	1996	It is now established that the lysine binding site (LBS) of apo(a) kringle IV-10, and particularly Trp72, plays a dominant role in the binding of lipoprotein(a) [Lp(a)] to lysine.	Lysine	31-37	lipoprotein(a)	Homo sapiens	162-167
8690792-1	1996	It is now established that the lysine binding site (LBS) of apo(a) kringle IV-10, and particularly Trp72, plays a dominant role in the binding of lipoprotein(a) [Lp(a)] to lysine.	Lysine	172-178	lipoprotein(a)	Homo sapiens	162-167
8690792-4	1996	Our results show that both Lyst and Lys- Lp(a)s and their derived apo(a)s, bound to PM-fibrinogen with similar affinities (Kds: 33-100 nM), whereas the B(max) values were threefold higher for apo(a)s. Both the lysine analog epsilon-aminocaproic acid and L-proline inhibited the binding of Lp(a) and apo(a) to PM fibrinogen.	Lysine	210-216	lysosomal trafficking regulator	Homo sapiens	27-31
15173587-3	2004	Here, we demonstrate that the erythroid transcription factor GATA-1 is sumoylated in vitro and in vivo and map the single lysine residue involved in SUMO-1 attachment.	Lysine	122-128	small ubiquitin like modifier 1	Homo sapiens	149-155
20933223-2	2010	In a reaction with the lysines of bovine heart cytochrome c, R5P generates superoxide (O2-) that subsequently reduces ferri-cytochrome c to ferro-cytochrome c.	Lysine	23-30	LOC104968582	Bos taurus	124-136
15044463-0	2004	C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase.	Lysine	11-18	creatine kinase, mitochondrial 2	Homo sapiens	57-97
15044463-2	2004	Three C-terminal basic residues revealed as putative cardiolipin anchors in the x-ray structures of MtCK and corresponding to lysines in human sarcomeric MtCK (sMtCK) were exchanged by in vitro mutagenesis (K369A/E, K379Q/A/E, K380Q/A/E) to yield double and triple mutants.	Lysine	126-133	creatine kinase, mitochondrial 2	Homo sapiens	143-158
15044463-2	2004	Three C-terminal basic residues revealed as putative cardiolipin anchors in the x-ray structures of MtCK and corresponding to lysines in human sarcomeric MtCK (sMtCK) were exchanged by in vitro mutagenesis (K369A/E, K379Q/A/E, K380Q/A/E) to yield double and triple mutants.	Lysine	126-133	creatine kinase, mitochondrial 2	Homo sapiens	160-165
8690792-4	1996	Our results show that both Lyst and Lys- Lp(a)s and their derived apo(a)s, bound to PM-fibrinogen with similar affinities (Kds: 33-100 nM), whereas the B(max) values were threefold higher for apo(a)s. Both the lysine analog epsilon-aminocaproic acid and L-proline inhibited the binding of Lp(a) and apo(a) to PM fibrinogen.	Lysine	210-216	lipoprotein(a)	Homo sapiens	41-46
8654981-1	1996	The LYS2 and LYS5 genes of Saccharomyces cerevisiae together encode the 180-kDa alpha-aminoadipate reductase (AAR) in the biosynthetic pathway of lysine.	Lysine	146-152	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	4-8
8654981-1	1996	The LYS2 and LYS5 genes of Saccharomyces cerevisiae together encode the 180-kDa alpha-aminoadipate reductase (AAR) in the biosynthetic pathway of lysine.	Lysine	146-152	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	13-17
20933223-2	2010	In a reaction with the lysines of bovine heart cytochrome c, R5P generates superoxide (O2-) that subsequently reduces ferri-cytochrome c to ferro-cytochrome c.	Lysine	23-30	LOC104968582	Bos taurus	124-136
21124965-2	2010	As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysine 4 of histone H3 (H3K4me3) to regulate chromatin modification and gene expression.	Lysine	75-81	inhibitor of growth family member 2	Homo sapiens	46-50
8672545-2	1996	Two kinds of full length CDD cDNA were identified from human placenta: one has glutamine and the other one has lysine at codon 27.	Lysine	111-117	cytidine deaminase	Homo sapiens	25-28
15044463-9	2004	Thus, the three C-terminal lysines determine high affinity sMtCK/cardiolipin interaction and its effects on MtCK structure, whereas low level binding and some effect on membrane fluidity depend on other structural components.	Lysine	27-34	creatine kinase, mitochondrial 2	Homo sapiens	59-64
21070970-5	2010	Mutation of key lysines prevents ubiquitylation of Cse4 by Psh1 in vitro and stabilizes Cse4 in vivo.	Lysine	16-23	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	51-55
15114532-1	2004	The hemoglobin E variant (HbE; ( beta )26Glu--&gt;Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium falciparum malaria.	Lysine	50-53	hemoglobin subunit epsilon 1	Homo sapiens	26-29
8621565-3	1996	We now demonstrate that pro-MT-MMP-1 mutants are efficiently processed to active proteinases following post-translational endoproteolysis immediately downstream of an Arg108-Arg-Lys-Arg basic motif by a proprotein convertase-dependent pathway.	Lysine	178-181	matrix metallopeptidase 14	Homo sapiens	28-36
21070970-5	2010	Mutation of key lysines prevents ubiquitylation of Cse4 by Psh1 in vitro and stabilizes Cse4 in vivo.	Lysine	16-23	ubiquitin-protein ligase PSH1	Saccharomyces cerevisiae S288C	59-63
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Lysine	37-43	lipoprotein(a)	Homo sapiens	172-189
15138284-5	2004	Mutating two key positively charged lysines to neutral alanines in the NLS of full-length p120(ctn) inhibited both p120(ctn) nuclear localization as well as the characteristic p120(ctn)-induced branching phenotype that correlates with increased cell migration.	Lysine	36-43	catenin delta 1	Homo sapiens	90-94
15138284-5	2004	Mutating two key positively charged lysines to neutral alanines in the NLS of full-length p120(ctn) inhibited both p120(ctn) nuclear localization as well as the characteristic p120(ctn)-induced branching phenotype that correlates with increased cell migration.	Lysine	36-43	catenin delta 1	Homo sapiens	115-119
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Lysine	37-43	lipoprotein(a)	Homo sapiens	191-197
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Lysine	45-48	lipoprotein(a)	Homo sapiens	172-189
15138284-5	2004	Mutating two key positively charged lysines to neutral alanines in the NLS of full-length p120(ctn) inhibited both p120(ctn) nuclear localization as well as the characteristic p120(ctn)-induced branching phenotype that correlates with increased cell migration.	Lysine	36-43	catenin delta 1	Homo sapiens	115-119
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Lysine	45-48	lipoprotein(a)	Homo sapiens	191-197
21070970-5	2010	Mutation of key lysines prevents ubiquitylation of Cse4 by Psh1 in vitro and stabilizes Cse4 in vivo.	Lysine	16-23	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	88-92
8630665-9	1996	We conclude that kringle IV-10 of human apo(a) has Lys- and PM-fibrinogen-binding capacities that are independent of glycosylation and require the presence of Trp72, one of the seven amino acids that constitute the Lys-binding site of kringle IV-10.	Lysine	51-54	lipoprotein(a)	Homo sapiens	40-46
20962278-3	2010	PRLR-recruited CREB-binding protein (CBP) acetylates multiple lysine sites randomly distributed along the cytoplasmic loop of PRLR.	Lysine	62-68	prolactin receptor	Homo sapiens	0-4
8630665-9	1996	We conclude that kringle IV-10 of human apo(a) has Lys- and PM-fibrinogen-binding capacities that are independent of glycosylation and require the presence of Trp72, one of the seven amino acids that constitute the Lys-binding site of kringle IV-10.	Lysine	215-218	lipoprotein(a)	Homo sapiens	40-46
15131252-6	2004	The coactivator function of HsfB1 depends on a histone-like motif in its C-terminal domain with an indispensable Lys residue in the center (GRGKMMK).	Lysine	113-116	heat shock factor 4	Arabidopsis thaliana	28-33
20962278-3	2010	PRLR-recruited CREB-binding protein (CBP) acetylates multiple lysine sites randomly distributed along the cytoplasmic loop of PRLR.	Lysine	62-68	prolactin receptor	Homo sapiens	126-130
8557633-12	1996	These results demonstrate that occupation of lysine binding sites modulates the affinity of SK for Pg and the changes in the environment of the catalytic site associated with SK-induced conformational activation.	Lysine	45-51	plasminogen	Homo sapiens	99-101
20962278-4	2010	Two PRLR monomers appear to interact with each other at multiple parts from the membrane-proximal region to the membrane-distal region, relying on the coordination among multiple lysine sites neutralized via acetylation.	Lysine	179-185	prolactin receptor	Homo sapiens	4-8
20736164-6	2010	These phenotypes require the central region of USP8, containing three extended Arg-X-X-Lys (RXXK) motifs that specify direct low affinity interactions with the SH3 domain(s) of ESCRT-0 proteins, STAM1/2.	Lysine	87-90	ubiquitin specific peptidase 8	Homo sapiens	47-51
8530405-5	1995	The most interesting observation was noted with two point mutants of LH/CG-R, Glu332--&gt;Lys and Asp333--&gt;Lys, which bound hCG but failed to give increased cAMP production.	Lysine	110-113	hypertrichosis 2 (generalised, congenital)	Homo sapiens	127-130
8519753-3	1995	RNase A was modified by a two-step labeling strategy involving prior modification of the C-terminus with the donor probe by enzymatic methods, followed by modification of lysine epsilon-amino groups with the coumarin derivative.	Lysine	171-177	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
15146484-14	2004	Our study provides direct thermodynamic data revealing that peptide binding to Pex5p-C binding is favored by lysine in the (-4) position and leucine in the (-5) position.	Lysine	109-115	peroxisomal biogenesis factor 5	Homo sapiens	79-84
15140045-2	2004	The new allele is identical to DQA1*0401 at exon 2 except for a single-nucleotide substitution at codon 53, changing it from lysine to a stop codon (CAA-->TAA).	Lysine	125-131	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	31-35
20967218-3	2010	The plant trithorax factor (ATX1) tri-methylates the lysine 4 residue of histone H3 (H3K4me3) at gene coding sequences, which positively correlates with gene transcription.	Lysine	53-59	homolog of anti-oxidant 1	Arabidopsis thaliana	28-32
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	119-123
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	210-214
7592877-4	1995	We previously found that human colon carcinoma LoVo cells have a frameshift mutation within the homo B domain of furin and thereby lack processing activity toward Arg-X-Lys/Arg-Arg sites.	Lysine	169-172	furin, paired basic amino acid cleaving enzyme	Homo sapiens	113-118
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	289-293
20675387-0	2010	Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.	Lysine	130-136	Lysine (K)-specific demethylase 4B	Drosophila melanogaster	57-63
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	294-299
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	DNA helicase RAD5	Saccharomyces cerevisiae S288C	302-306
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	250-256	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	119-123
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	250-256	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	210-214
15121847-4	2004	PCNA is also modified by SUMO conjugation at the lysine 164 residue.	Lysine	49-55	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	0-4
15121847-6	2004	In addition, we provide evidence for the activation of the RAD52 recombinational pathway in the pol30-119 mutant and we infer that SUMO conjugation at the lysine 164 residue of PCNA has a role in suppressing the Rad52-dependent postreplicational repair pathway.	Lysine	155-161	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	177-181
7578231-9	1995	1H-NMR spectroscopy of the HMW complex formed between alpha-crystallin and gamma-crystallin indicates that the short C-terminal extension of alpha B-crystallin, but not that of alpha A-crystallin, has lost its flexibility in the complex implying that the former is involved in interactions with the unfolded gamma-crystallin molecule, possibly electrostatically via its two C-terminal lysine residues.	Lysine	385-391	crystallin alpha B	Bos taurus	141-159
20705923-10	2010	HDAC3 inhibits aspirin-stimulated (1) lysine acetylation of eNOS, (2) eNOS enzymatic activity, (3) eNOS-derived NO, and (4) binding of eNOS to calmodulin.	Lysine	38-44	histone deacetylase 3	Homo sapiens	0-5
7554377-8	1995	One serum with anti-PR3 antibodies bound to Lys-C and Glu-C-digested PR3 in dot blots.	Lysine	44-47	proteinase 3	Homo sapiens	20-23
20705923-11	2010	Conversely, downregulation of HDAC3 promotes lysine acetylation of eNOS and endothelial NO generation.	Lysine	45-51	histone deacetylase 3	Homo sapiens	30-35
15096036-4	2004	This apparent conformational change was further investigated using differential chemical modification of 3-OST-1 to measure the solvent accessibility of the lysine residues.	Lysine	157-163	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	105-112
15096036-8	2004	In particular, we observed a group of lysine residues in the C-terminus of 3-OST-1 that become more solvent accessible when 3-OST-1 binds to HS.	Lysine	38-44	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	75-82
20601085-8	2010	By spot mapping analysis we first identified Lys 117 and 251 as the putative GAPDH residues that could be acetylated by PCAF.	Lysine	45-48	lysine acetyltransferase 2B	Homo sapiens	120-124
15096036-8	2004	In particular, we observed a group of lysine residues in the C-terminus of 3-OST-1 that become more solvent accessible when 3-OST-1 binds to HS.	Lysine	38-44	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	124-131
7588773-5	1995	The binding activity of prothymosin alpha to Rev or Rex was completely abolished when the epsilon-amino groups of its lysine residues were chemically modified by N-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate.	Lysine	118-124	Rev	Human immunodeficiency virus 1	45-48
20668333-3	2010	Here, we show that Rtt109p promotes the eviction of histone H3 from a fast inducible yeast gene, GAL1, following transcriptional initiation via histone H3 Lys(56) acetylation.	Lysine	155-158	galactokinase	Saccharomyces cerevisiae S288C	97-101
7565712-4	1995	All inserts were flanked by 6- to 9-bp direct repeats of LYS2 sequence, providing an opportunity for Lys+ reversion via precise excision.	Lysine	101-105	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	57-61
15086470-7	2004	Using reverse transcription-polymerase chain reaction (RT-PCR), Northern blotting, and immunohistochemistry, we found a significant increase in glomerular cationic amino acid transporter-1 (CAT-1) expression in diabetic animals, which was unaffected by lysine.	Lysine	253-259	solute carrier family 7 member 1	Rattus norvegicus	155-188
15086470-7	2004	Using reverse transcription-polymerase chain reaction (RT-PCR), Northern blotting, and immunohistochemistry, we found a significant increase in glomerular cationic amino acid transporter-1 (CAT-1) expression in diabetic animals, which was unaffected by lysine.	Lysine	253-259	solute carrier family 7 member 1	Rattus norvegicus	190-195
20668333-5	2010	Intriguingly, we also find that the deposition of histone H2B on preexisting non-acetylated histone H3 Lys(56) at GAL1 in Deltartt109 is significantly increased independently of histone H3 deposition immediately following transcriptional termination subsequent to a short induction.	Lysine	103-106	galactokinase	Saccharomyces cerevisiae S288C	114-118
21047201-8	2010	Any grade 3 or 4 hematological toxicity was significantly associated with the Gln/Gln or Lys/Gln + Gln/Gln genotypes of XPC compared with Lys/Lys (aOR: 10; 95% CI: 2.0-65; p = 0.0070 or aOR: 6.3; 95% CI: 1.9-29; p = 0.0069; respectively).	Lysine	89-92	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	120-123
14701845-6	2004	Replacing another conserved residue critical for ATP binding and kinase activity, Lys-35 (K35A), reduced Cdc37-Cdk4 complex formation but to a lesser extent.	Lysine	82-85	cell division cycle 37, HSP90 cochaperone	Homo sapiens	105-110
14701845-6	2004	Replacing another conserved residue critical for ATP binding and kinase activity, Lys-35 (K35A), reduced Cdc37-Cdk4 complex formation but to a lesser extent.	Lysine	82-85	cyclin dependent kinase 4	Homo sapiens	111-115
7559414-0	1995	Enhanced plasmin inhibition by a reactive center lysine mutant of the Kunitz-type protease inhibitor domain of the amyloid beta-protein precursor.	Lysine	49-55	plasminogen	Homo sapiens	9-16
7642593-2	1995	Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1.	Lysine	21-24	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
7642593-2	1995	Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1.	Lysine	66-69	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
20936109-7	2010	We found that H2AX is ubiquitinated at lysines 119 and 119 in vivo and that blockage of 26S proteasome function stabilizes gamma-H2AX levels within cells.	Lysine	39-46	H2A.X variant histone	Homo sapiens	14-18
15127790-4	2004	In contrast, substitution of Trp for Lys and Thr at positions 2, 15 and 19 of HP(2-9)-ME(1-12), respectively (HM3 and HM4), decreased activity but increased hemolysis against human erythrocytes.	Lysine	37-40	defensin alpha 3	Homo sapiens	78-84
15127790-4	2004	In contrast, substitution of Trp for Lys and Thr at positions 2, 15 and 19 of HP(2-9)-ME(1-12), respectively (HM3 and HM4), decreased activity but increased hemolysis against human erythrocytes.	Lysine	37-40	cholinergic receptor muscarinic 3	Homo sapiens	110-113
7653523-6	1995	Lys-539, a probable reaction site of BSSS, lies within the same segment of AE1 that is labeled by NAP-taurine and thus may be part of the modifier site.	Lysine	0-3	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	75-78
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	phospholipase C gamma 2	Homo sapiens	80-90
7627705-11	1995	Specific chemical modification of lysine amino groups by acetylation similarly led to inactivation of LDL-associated TFPI activity.	Lysine	34-40	tissue factor pathway inhibitor	Homo sapiens	117-121
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	phospholipase C gamma 2	Homo sapiens	111-120
20800574-5	2010	Since these two modes of ubiquitination target the same lysine residues and are therefore mutually exclusive, an important mode of regulation of RING1B should be at the level of deubiquitination.	Lysine	56-62	ring finger protein 2	Homo sapiens	145-151
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	185-188	phospholipase C gamma 2	Homo sapiens	80-90
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	185-188	phospholipase C gamma 2	Homo sapiens	111-120
7619075-13	1995	Furin does not process rPSS to PSS-(1-10), suggesting the existence of another monobasic convertase with a preference for Lys rather than Arg at P1.	Lysine	122-125	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
20587414-0	2010	p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals.	Lysine	40-46	E1A binding protein p300	Homo sapiens	0-4
7615163-3	1995	Plasmin(ogen) binds to cells with low affinity and high capacity via its lysine binding sites, which are associated with its kringle domains and recognize carboxy-terminal lysines of cell surface proteins.	Lysine	73-79	plasminogen	Homo sapiens	0-7
7615163-3	1995	Plasmin(ogen) binds to cells with low affinity and high capacity via its lysine binding sites, which are associated with its kringle domains and recognize carboxy-terminal lysines of cell surface proteins.	Lysine	172-179	plasminogen	Homo sapiens	0-7
14645257-12	2004	Consistent with the open conformation of the Lys(63)-linked di-ubiquitin, our binding studies show that both ubiquitin domains in this chain can bind a ubiquitin-associated domain from HHR23A independently and in a mode similar to that for mono-ubiquitin.	Lysine	45-48	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	185-191
14638690-7	2004	The BRCA1-BARD1-mediated Lys-6-linked polyubiquitin chains are deubiquitinated by 26 S proteasome in vitro, whereas autoubiquitinated CUL1 through Lys-48-linked polyubiquitin chains is degraded.	Lysine	25-28	cullin 1	Homo sapiens	134-138
20678485-6	2010	In addition, we demonstrate that a lysine-rich region (aa 101-140) in the first half of DNA binding domain of the Dot1p is critical in interaction with ubiquitin as well as binding to nucleosome core.	Lysine	35-41	ubiquitin	Saccharomyces cerevisiae S288C	152-161
20678485-8	2010	Taken together, our results indicate that a direct interaction between the lysine-rich region of Dot1p and the ubiquitin of H2Bub is required for H2Bub-mediated trans-tail regulation.	Lysine	75-81	ubiquitin	Saccharomyces cerevisiae S288C	111-120
20534592-1	2010	Pyridoxal 5"-phosphate (PLP)-dependent basic amino acid decarboxylases from the beta/alpha-barrel-fold class (group IV) exist in most organisms and catalyze the decarboxylation of diverse substrates, essential for polyamine and lysine biosynthesis.	Lysine	228-234	pyridoxal phosphatase	Homo sapiens	24-27
15101559-7	2004	Furthermore, when administered in vivo together with glucose to diabetic (ob/ob) mice, [Lys(pal)26]GLP-1, [Abu8,Lys(pal)26]GLP-1 and [Val8,Lys(pal)26]GLP-1 did not demonstrate acute glucose-lowering or insulinotropic activity as observed with native GLP-1.	Lysine	88-91	glucagon	Mus musculus	99-104
7558939-2	1995	The codon for Glu 69 in the DPB1*02012 allele was changed to the codon for Lys found in DPB1*0402, and transfectant L cells expressing wild-type or mutant HLA-DP molecule were obtained.	Lysine	75-78	major histocompatibility complex, class II, DP beta 1	Homo sapiens	28-32
7558939-2	1995	The codon for Glu 69 in the DPB1*02012 allele was changed to the codon for Lys found in DPB1*0402, and transfectant L cells expressing wild-type or mutant HLA-DP molecule were obtained.	Lysine	75-78	major histocompatibility complex, class II, DP beta 1	Homo sapiens	88-92
7476960-2	1995	Only lysine-33 is cross-linkable in specific complex with lac operator.	Lysine	5-11	lactase	Homo sapiens	58-61
20516075-9	2010	This study suggests that genetic variations in SHP are common among human subjects and the Lys-170 residue plays a key role in controlling SHP ubiquitination and acetylation associated with SHP protein stability and repressive function.	Lysine	91-94	nuclear receptor subfamily 0 group B member 2	Homo sapiens	47-50
20516075-9	2010	This study suggests that genetic variations in SHP are common among human subjects and the Lys-170 residue plays a key role in controlling SHP ubiquitination and acetylation associated with SHP protein stability and repressive function.	Lysine	91-94	nuclear receptor subfamily 0 group B member 2	Homo sapiens	139-142
7670372-4	1995	Through the analysis of known barrel structures we developed a topographic model of the pyridoxal phosphate-binding domain of ornithine decarboxylase, which predicts that the Schiff base lysine and a conserved glycine-rich sequence both map to the C-termini of the beta-strands.	Lysine	187-193	ornithine decarboxylase 1	Homo sapiens	126-149
14593114-6	2004	In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys(48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase involved in protein degradation.	Lysine	118-121	synoviolin 1	Homo sapiens	180-184
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	25-31	NEDD8 ubiquitin like modifier	Homo sapiens	61-66
14745782-2	2004	The LYS5MX and CaLYS5MX cassettes, the targeting efficiencies of which are equivalent to those of other MX cassettes, are positively selected for Lys+ in a lys5 background.	Lysine	146-149	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	156-160
7671135-6	1995	The residue Lys-562 of human band 3 was found to be modified with PLP, while the corresponding residue of bovine band 3 was devoid of reactivity with PLP.	Lysine	12-15	pyridoxal phosphatase	Homo sapiens	66-69
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	166-172	NEDD8 ubiquitin like modifier	Homo sapiens	61-66
7584795-1	1995	New data on the interactions between lipoprotein (a) [Lp(a)] and the coagulation-fibrinolytic system, which emphasize the importance of the activity of lysine-binding sites on apolipoprotein (a) [apo(a)], provide an increasingly strong basis for the role of Lp(a) in thrombosis.	Lysine	152-158	lipoprotein(a)	Homo sapiens	54-59
7584795-1	1995	New data on the interactions between lipoprotein (a) [Lp(a)] and the coagulation-fibrinolytic system, which emphasize the importance of the activity of lysine-binding sites on apolipoprotein (a) [apo(a)], provide an increasingly strong basis for the role of Lp(a) in thrombosis.	Lysine	152-158	lipoprotein(a)	Homo sapiens	258-263
14570930-1	2004	Drosophila suppressor of zeste 12 (Su(z)12) is a Polycomb group (PcG) transcriptional repressor and is present in E(z)-ESC, a multiprotein complex with methylation activity specific for lysine 9 and 27 of histone H3.	Lysine	186-192	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	35-42
20620066-6	2010	Based on the selected sequences the two peptide aldehydes were synthesized and (Abz-Arg-Gln-Asp-Arg(Lys)-H) were found to be an effective HAT inhibitor, working in nanomolar range with inhibition constant 54nM and 112nM, respectively.	Lysine	100-103	transmembrane serine protease 11D	Homo sapiens	138-141
20501661-5	2010	We also demonstrate that acetylation of SMC3 at Lys(105) and Lys(106) is induced by IR and this induction depends on the acetyltransferase ESCO1 as well as the ATM/ATR kinases.	Lysine	48-51	structural maintenance of chromosomes 3	Homo sapiens	40-44
13130121-1	2004	Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,326 and apo[a]Cys4,057.	Lysine	79-85	lipoprotein(a)	Homo sapiens	16-20
7755639-3	1995	A KEKE motif, consisting of a very hydrophilic domain rich in "alternating" lysine (positive) and glutamate (negative) residues, is present in the C-terminus of p40.	Lysine	76-82	interleukin 9	Homo sapiens	161-164
20488183-0	2010	Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway.	Lysine	23-29	H2A.X variant histone	Homo sapiens	15-19
7713891-2	1995	This work is aimed at understanding subunit assembly in the tryptophan synthase alpha 2 beta 2 complex and the importance of the internal aldimine between pyridoxal phosphate and lysine 87 of the beta 2 subunit of tryptophan synthase for subunit association.	Lysine	179-185	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	196-202
7641295-8	1995	Amino acid sequence of CBP-140 contains a carboxyl-terminal Asn-Asp-Glu-Leu (NDEL) sequence, which resembles Lys-Asp-Glu-Leu (KDEL) sequence, a signal to retain the resident proteins in endoplasmic reticulum; NDEL sequence may indeed play a similar role.	Lysine	109-112	hypoxia up-regulated 1	Mus musculus	23-30
14717962-2	2004	An internal fragment of plasminogen, angiostatin consists of kringle domains that are known to be lysine-binding.	Lysine	98-104	plasminogen	Mus musculus	37-48
15171252-6	2004	Distinct "hotspots" of histone H3 dimethylated at lysine 4 are localized at the ends of the active DJ domains of both the IgH and TCRbeta loci, suggesting they may serve as important marks for locus accessibility.	Lysine	50-56	immunoglobulin heavy constant delta	Homo sapiens	122-125
15171254-2	2004	In addition, Tat synergizes with the histone acetyltransferase p300 and is acetylated by p300 at a single lysine residue (K50) in the TAR RNA binding domain.	Lysine	106-112	E1A binding protein p300	Homo sapiens	89-93
15171256-3	2004	The p300/CBP acetyltransferases play a major role in the in vivo acetylation of RelA principally targeting lysines 218, 221 and 310 for modification.	Lysine	107-114	E1A binding protein p300	Homo sapiens	4-8
15171256-3	2004	The p300/CBP acetyltransferases play a major role in the in vivo acetylation of RelA principally targeting lysines 218, 221 and 310 for modification.	Lysine	107-114	RELA proto-oncogene, NF-kB subunit	Homo sapiens	80-84
15171256-5	2004	Specifically, acetylation of lysine 221 enhances DNA binding and impairs assembly with I-kappaBalpha while acetylation of lysine 310 is required for full transcriptional activity of RelA independent of changes in DNA binding or I-kappaBalpha binding.	Lysine	122-128	RELA proto-oncogene, NF-kB subunit	Homo sapiens	182-186
15171256-7	2004	Deacetylation of lysine 221 promotes high-affinity binding of RelA to newly synthesized I-kappaBalpha proteins whose expression is activated by NF-kappaB.	Lysine	17-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	62-66
14661947-6	2003	In contrast, while the histone H3 complex shows extensive interactions with tGcn5 and peptide residues N-terminal to the target lysine, the corresponding residues in histone H4 and p53 are disordered, suggesting that the N-terminal substrate region plays an important role in the enhanced affinity of the Gcn5/PCAF HAT proteins for histone H3.	Lysine	128-134	lysine acetyltransferase 2B	Homo sapiens	310-314
7766072-1	1995	The enzyme has the ability to release arginine and lysine from the carboxy terminus of peptides, and showed high specific activity against arginine (140 units mg-1 protein).	Lysine	51-57	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	159-163
20488183-2	2010	Here, we report that H2AX is constitutively acetylated on lysine 36 (H2AXK36Ac) by the CBP/p300 acetyltransferases.	Lysine	58-64	H2A.X variant histone	Homo sapiens	21-25
20457643-5	2010	AtGCN5 targets to a large number of promoters and is required for acetylation of several histone H3 lysine residues.	Lysine	100-106	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	0-6
7862160-4	1995	Sequencing of the complementing gene predicts the Ref2p product to be a novel, basic protein of 429 amino acids (M(r), 48,000) with a high-level lysine/serine content and some unusual features.	Lysine	145-151	RNA-processing protein REF2	Saccharomyces cerevisiae S288C	50-55
20457643-6	2010	Recruitment of AtGCN5 to target promoters is likely to be mediated by direct or indirect interaction with DNA-binding transcription factors and/or by interaction with acetylated histone lysine residues on the targets.	Lysine	186-192	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	15-21
12975326-4	2003	We show that, in both DMRs, the active alleles of both Igf2r, and Air are associated with acetylated histones (H3, and H4), acetyl lysine 9 of histone H3 (H3 K9-Ac), and methyl lysine 4 of histone H3 (H3 K4-Me).	Lysine	131-137	insulin-like growth factor 2 receptor	Mus musculus	55-60
20479123-0	2010	MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.	Lysine	34-40	lysine acetyltransferase 8	Homo sapiens	0-3
15008512-4	2003	The docking results showed that compounds (4), (25) and (26) were bound to the active site of the enzyme Lys 295 of p60(c-Src) tyrosine kinase.	Lysine	105-108	C-terminal Src kinase	Homo sapiens	120-142
7542625-3	1995	Binding was inhibited by beta-endorphin"s C-terminal tetrapeptide, lys-lys-gly-glu, but not by the truncated N-terminal 27 amino acid fragment, indicating that binding of beta-endorphin to this receptor is dependent on its C-terminus.	Lysine	67-70	pro-opiomelanocortin-alpha	Mus musculus	25-39
7542625-3	1995	Binding was inhibited by beta-endorphin"s C-terminal tetrapeptide, lys-lys-gly-glu, but not by the truncated N-terminal 27 amino acid fragment, indicating that binding of beta-endorphin to this receptor is dependent on its C-terminus.	Lysine	67-70	pro-opiomelanocortin-alpha	Mus musculus	171-185
20479123-1	2010	The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac).	Lysine	80-86	lysine acetyltransferase 8	Homo sapiens	10-13
7813075-5	1995	Two mutations can occur in kringle 4 type 10: one, Trp72--&gt;Arg, is affiliated with an Lp(a) that is lysine-binding defective; the other, Met66--&gt;Thr, with a normal lysine-binding function.	Lysine	103-109	lipoprotein(a)	Homo sapiens	89-94
20484414-5	2010	Purified PCAF acetylated the DNA-binding domain of ERRalpha on four highly-conserved lysines.	Lysine	85-92	K(lysine) acetyltransferase 2B	Mus musculus	9-13
14500761-7	2003	Deciphering the unique sumoylation pattern of hMR, which possesses five consensus SUMO-1 binding sites, by combinatorial lysine substitutions, revealed a major impact of sumoylation on hMR properties.	Lysine	121-127	mannose receptor C-type 1	Homo sapiens	46-49
14500761-7	2003	Deciphering the unique sumoylation pattern of hMR, which possesses five consensus SUMO-1 binding sites, by combinatorial lysine substitutions, revealed a major impact of sumoylation on hMR properties.	Lysine	121-127	small ubiquitin like modifier 1	Homo sapiens	82-88
20390229-2	2010	We have previously identified lysine-binding site-independent plasmin-interactive sites on the FVIII A2 domain responsible for cleavages at Arg336 and Arg372, together with lysine-binding site-dependent plasmin sites on the light chain responsible for cleavage at Lys36.	Lysine	30-36	plasminogen	Homo sapiens	62-69
14500761-7	2003	Deciphering the unique sumoylation pattern of hMR, which possesses five consensus SUMO-1 binding sites, by combinatorial lysine substitutions, revealed a major impact of sumoylation on hMR properties.	Lysine	121-127	mannose receptor C-type 1	Homo sapiens	185-188
14580393-3	2003	Detroit 562 cells preferentially bound to Lys-plasminogen and this binding was inhibited in the presence of a lysine analog, epsilon-aminocaproic acid and by carboxypeptidase-B treatment suggesting that the C-terminal lysine residue of the putative pharyngeal cell receptor(s) may play an important role in plasminogen-binding.	Lysine	110-116	plasminogen	Homo sapiens	46-57
14580393-3	2003	Detroit 562 cells preferentially bound to Lys-plasminogen and this binding was inhibited in the presence of a lysine analog, epsilon-aminocaproic acid and by carboxypeptidase-B treatment suggesting that the C-terminal lysine residue of the putative pharyngeal cell receptor(s) may play an important role in plasminogen-binding.	Lysine	218-224	plasminogen	Homo sapiens	46-57
7697930-9	1995	IgAN displayed an enhanced production of IgA reacting with mesangial matrix components vs CGN (p &lt; 0.03) and U (p &lt; 0.0003) groups and showed altered interactions with positively charged molecules (poly-L-Lysine, p &lt; 0.01) and carbohydrate residues (jacalin p &lt; 0.05).	Lysine	204-217	IGAN1	Homo sapiens	0-4
7703285-1	1995	Surfactant protein A (SP-A) was modified by covalent linkage with polylysine of average M(r) 21 kD ([Lys]21kD-SP-A) and utilized to transfect human airway epithelial cells (H441) in vitro.	Lysine	101-104	surfactant protein A1	Homo sapiens	0-20
7703285-1	1995	Surfactant protein A (SP-A) was modified by covalent linkage with polylysine of average M(r) 21 kD ([Lys]21kD-SP-A) and utilized to transfect human airway epithelial cells (H441) in vitro.	Lysine	101-104	surfactant protein A1	Homo sapiens	22-26
7703285-1	1995	Surfactant protein A (SP-A) was modified by covalent linkage with polylysine of average M(r) 21 kD ([Lys]21kD-SP-A) and utilized to transfect human airway epithelial cells (H441) in vitro.	Lysine	101-104	surfactant protein A1	Homo sapiens	110-114
7703285-2	1995	Transfection of H441 cells was more efficient with [Lys]21kD-SP-A than with polylysine-DNA or unmodified SP-A-DNA complexes.	Lysine	52-55	surfactant protein A1	Homo sapiens	61-65
7703285-3	1995	Transfection with [Lys]21kD-SP-A was effective at a protein-to-DNA molar ratio of 400:1 and in the presence of an exogenous surfactant preparation, Survanta.	Lysine	19-22	surfactant protein A1	Homo sapiens	28-32
7703285-4	1995	Transfection with [Lys]21kD-SP-A was reduced in the presence of unmodified SP-A consistent with the concept of a receptor mediated uptake of protein-DNA complexes.	Lysine	19-22	surfactant protein A1	Homo sapiens	28-32
7703285-4	1995	Transfection with [Lys]21kD-SP-A was reduced in the presence of unmodified SP-A consistent with the concept of a receptor mediated uptake of protein-DNA complexes.	Lysine	19-22	surfactant protein A1	Homo sapiens	75-79
7703285-5	1995	Increased transfection efficiency correlated with decreasing diameter of the [Lys]21kD-SP-A-DNA complexes, and these complexes bound to the cell surface and pseudopodia of H441 cells.	Lysine	78-81	surfactant protein A1	Homo sapiens	87-91
7703285-7	1995	Cotransfection by [Lys]21kD-SP-A-DNA and [Lys]10kD-SP-B resulted in an additive level of reporter gene (CAT) expression.	Lysine	19-22	surfactant protein A1	Homo sapiens	28-32
7703285-7	1995	Cotransfection by [Lys]21kD-SP-A-DNA and [Lys]10kD-SP-B resulted in an additive level of reporter gene (CAT) expression.	Lysine	42-45	surfactant protein B	Homo sapiens	51-55
14690593-5	2003	The APS SH2 dimer engages two kinase molecules, with pTyr-1158 of the kinase activation loop bound in the canonical phosphotyrosine binding pocket of the SH2 domain and a second phosphotyrosine, pTyr-1162, coordinated by two lysine residues in beta strand D. This structure provides a molecular visualization of one of the initial downstream recruitment events following insulin activation of its dimeric receptor.	Lysine	225-231	SH2B adaptor protein 2	Homo sapiens	4-7
20390229-2	2010	We have previously identified lysine-binding site-independent plasmin-interactive sites on the FVIII A2 domain responsible for cleavages at Arg336 and Arg372, together with lysine-binding site-dependent plasmin sites on the light chain responsible for cleavage at Lys36.	Lysine	30-36	coagulation factor VIII	Homo sapiens	95-100
20390229-2	2010	We have previously identified lysine-binding site-independent plasmin-interactive sites on the FVIII A2 domain responsible for cleavages at Arg336 and Arg372, together with lysine-binding site-dependent plasmin sites on the light chain responsible for cleavage at Lys36.	Lysine	173-179	plasminogen	Homo sapiens	203-210
7798229-2	1994	Methylglyoxal binds and irreversibly modifies arginine and lysine residues in bovine serum albumin (BSA) under physiological conditions, producing a protein with an increased net negative charge at physiological pH.	Lysine	59-65	albumin	Mus musculus	85-98
20390229-9	2010	6-aminohexanoic acid, a lysine analogue, significantly inhibited the light chain/K1-2-3 (and K4) binding by approximately 90%, whilst A2/K5-CD binding was moderated by only approximately 35%.	Lysine	24-30	secreted and transmembrane 1	Homo sapiens	81-87
20585391-5	2010	Mutation of F595 to Ala, Lys, Val or Ile significantly decreases the constitutive activity of JAK2 V617F, but F595W and F595Y are able to restore it, implying an aromaticity requirement at position 595.	Lysine	25-28	Janus kinase 2	Homo sapiens	94-98
7981216-3	1994	In this study, a lysine residue, conserved within transmembrane domain 3 (TM3) of the ETA and ETB receptor subtypes, is implicated in agonist and antagonist binding by its analogous position within TM3 to a binding site aspartate residue conserved within bioactive amine receptors.	Lysine	17-23	endothelin receptor type A	Homo sapiens	86-89
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Lysine	246-249	ribonuclease A family member 1, pancreatic	Homo sapiens	74-88
12964199-1	2003	The second step in the enzyme-catalyzed hydrolysis of phosphate esters by ribonuclease A (RNase A) was studied using an ab initio quantum-based model of the active site including constrained parts of three critical residues, His-12, His-119, and Lys-41, and a small substrate.	Lysine	246-249	ribonuclease A family member 1, pancreatic	Homo sapiens	90-97
20181793-7	2010	Single amino acid substitution experiments revealed that Lys(272) of the fourth loop on the cytosolic side of CST is essential for transport activity.	Lysine	57-60	solute carrier family 35 member A1	Homo sapiens	110-113
14560007-7	2003	The assay combines the spatial resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues.	Lysine	236-242	E1A binding protein p300	Homo sapiens	166-170
14572647-0	2003	The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists.	Lysine	23-26	glucagon like peptide 1 receptor	Homo sapiens	63-78
7969127-2	1994	In several cases, it has been shown that the proteolytic signal takes the form of a multi-Ub chain in which successive Ub molecules are linked tandemly at lysine 48 (K-48).	Lysine	155-161	ubiquitin	Saccharomyces cerevisiae S288C	90-92
7969127-2	1994	In several cases, it has been shown that the proteolytic signal takes the form of a multi-Ub chain in which successive Ub molecules are linked tandemly at lysine 48 (K-48).	Lysine	155-161	ubiquitin	Saccharomyces cerevisiae S288C	119-121
7969127-3	1994	Here we show that Ub molecules can be linked together in vivo at two other lysine positions, lysine 29 (K-29) and lysine 63 (K-63).	Lysine	75-81	ubiquitin	Saccharomyces cerevisiae S288C	18-20
7969127-3	1994	Here we show that Ub molecules can be linked together in vivo at two other lysine positions, lysine 29 (K-29) and lysine 63 (K-63).	Lysine	93-99	ubiquitin	Saccharomyces cerevisiae S288C	18-20
7969127-3	1994	Here we show that Ub molecules can be linked together in vivo at two other lysine positions, lysine 29 (K-29) and lysine 63 (K-63).	Lysine	93-99	ubiquitin	Saccharomyces cerevisiae S288C	18-20
20181793-8	2010	Mutation of the conserved Lys residue (Lys(297)) in the UDP-galactose transporter (UGT) also resulted in a complete loss of its activity.	Lysine	26-29	solute carrier family 35 member A2	Homo sapiens	56-81
14516784-8	2003	One SUMO-1 acceptor site at lysine residue 560 could be identified within this region.	Lysine	28-34	small ubiquitin like modifier 1	Homo sapiens	4-10
20181793-8	2010	Mutation of the conserved Lys residue (Lys(297)) in the UDP-galactose transporter (UGT) also resulted in a complete loss of its activity.	Lysine	26-29	solute carrier family 35 member A2	Homo sapiens	83-86
20181793-8	2010	Mutation of the conserved Lys residue (Lys(297)) in the UDP-galactose transporter (UGT) also resulted in a complete loss of its activity.	Lysine	39-42	solute carrier family 35 member A2	Homo sapiens	56-81
14514722-1	2003	WNK1 is a member of a novel serine/threonine kinase family, With-No-K, (lysine).	Lysine	72-78	WNK lysine deficient protein kinase 1	Mus musculus	0-4
7918682-0	1994	A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a).	Lysine	85-91	lipoprotein(a)	Homo sapiens	47-53
20181793-8	2010	Mutation of the conserved Lys residue (Lys(297)) in the UDP-galactose transporter (UGT) also resulted in a complete loss of its activity.	Lysine	39-42	solute carrier family 35 member A2	Homo sapiens	83-86
7918682-0	1994	A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a).	Lysine	85-91	lipoprotein(a)	Homo sapiens	110-115
20460436-1	2010	BRE1 encodes an E3 ubiquitin protein ligase that is required for the ubiquitylation of histone H2B at lysine 123 (K123).	Lysine	102-108	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	0-4
7918682-5	1994	Lysine binding has been associated with the thrombogenic potential of Lp(a).	Lysine	0-6	lipoprotein(a)	Homo sapiens	70-75
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Lysine	273-281	interleukin 4 induced 1	Homo sapiens	75-120
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Lysine	273-281	interleukin 4 induced 1	Homo sapiens	122-125
8086489-3	1994	Previously we have reported the involvement of Lys-140 located in the C-terminus of the second transmembrane region of the ETA receptor for ET-1 binding (Eur.	Lysine	47-50	endothelin receptor type A	Homo sapiens	123-126
12907950-3	2003	The lacZ gene contains a G to A nucleotide change, (Glu to Lys mutation) that abrogates beta-galactosidase activity.	Lysine	59-62	galactosidase beta 1	Homo sapiens	88-106
20473294-2	2010	In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of "bivalent" chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27).	Lysine	287-290	protein regulator of cytokinesis 1	Homo sapiens	123-127
8057461-9	1994	We also expressed and purified an nsP2 variant which had a single amino acid substitution in the nucleotide-binding motif (Lys-192--&gt;Asn).	Lysine	123-126	reticulon 2	Homo sapiens	34-38
8063713-9	1994	The third substrate, NFF-3 (Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2), was hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but there was no significant hydrolysis by MMP-1 and MMP-2.	Lysine	40-43	matrix metallopeptidase 2	Homo sapiens	249-254
12915181-3	2003	The additional sequence encodes a 100-amino acid, lysine-rich C-terminal extension of the RPS6 protein with 42-49% identity to histone H1 proteins from the chicken and other multicellular organisms.	Lysine	50-56	ribosomal protein S6	Gallus gallus	90-94
20473294-2	2010	In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of "bivalent" chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27).	Lysine	335-338	protein regulator of cytokinesis 1	Homo sapiens	123-127
12920522-5	2003	Both subunits are acetylated at multiple lysine residues with the p300/CBP acetyltransferases playing a major role in this process in vivo.	Lysine	41-47	E1A binding protein p300	Homo sapiens	66-70
20363750-0	2010	Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.	Lysine	15-21	GATA binding protein 2	Homo sapiens	136-141
14527417-6	2003	Furthermore, this repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus.	Lysine	148-154	metastasis associated 1 family member 2	Homo sapiens	164-168
8051162-4	1994	The mutant NSF proteins in which Lys-274 was replaced had no ability to restore protein transport between N-ethylmaleimide-treated Golgi membranes and, in addition, inhibited the protein transport assay using normal Golgi membranes.	Lysine	33-36	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	11-14
8051162-6	1994	Although wild-type NSF showed a protective effect against inhibition by the Lys-274 mutant NSF protein when added at the start of the protein transport assay, its protective effect diminished after the time for the formation of transport vesicles had passed.	Lysine	76-79	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	19-22
8051162-6	1994	Although wild-type NSF showed a protective effect against inhibition by the Lys-274 mutant NSF protein when added at the start of the protein transport assay, its protective effect diminished after the time for the formation of transport vesicles had passed.	Lysine	76-79	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	91-94
8051162-10	1994	The mutant NSF proteins in which Lys-274 and Lys-557 were replaced had about 20 and 25% of the ATPase activities of wild-type NSF, respectively.	Lysine	33-36	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	11-14
20363750-5	2010	Acetylation at Lys(564), which is adjacent to the CtBP-binding consensus sequence of EVI1, was found to be important for transcriptional activation of GATA2.	Lysine	15-18	GATA binding protein 2	Homo sapiens	151-156
8051162-10	1994	The mutant NSF proteins in which Lys-274 and Lys-557 were replaced had about 20 and 25% of the ATPase activities of wild-type NSF, respectively.	Lysine	33-36	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	126-129
20363750-9	2010	Thus, acetylation of EVI1 at Lys(564) by P/CAF enhances the DNA binding capacity of EVI1 and thereby contributes to the activation of GATA2.	Lysine	29-32	lysine acetyltransferase 2B	Homo sapiens	41-46
8051162-10	1994	The mutant NSF proteins in which Lys-274 and Lys-557 were replaced had about 20 and 25% of the ATPase activities of wild-type NSF, respectively.	Lysine	45-48	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	11-14
12963350-1	2003	Enteropeptidase (synonym:enterokinase, EC 3.4.21.9) is a heterodimeric serine protease of the intestinal brush border that activates trypsinogen by highly specific cleavage of the trypsinogen activation peptide following the sequence (Asp)(4)-Lys.	Lysine	243-246	transmembrane serine protease 15	Homo sapiens	0-15
20363750-9	2010	Thus, acetylation of EVI1 at Lys(564) by P/CAF enhances the DNA binding capacity of EVI1 and thereby contributes to the activation of GATA2.	Lysine	29-32	GATA binding protein 2	Homo sapiens	134-139
20371377-1	2010	P300/CBP associated factor (PCAF) acts as an acetyltransferase that acetylates specific lysine residues in histones, thereby remodelling chromatin structure.	Lysine	88-94	K(lysine) acetyltransferase 2B	Mus musculus	0-26
12783870-4	2003	In lysosomal arylsulfatase A only substitution of lysine residue 457 caused a reduction of phosphorylation to 33% and increased secretion of the mutant enzyme.	Lysine	50-56	arylsulfatase A	Homo sapiens	13-28
8052624-10	1994	The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (human) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like protease that cleaves the indicated Lys-Ile bond.	Lysine	254-257	transmembrane serine protease 15	Bos taurus	62-74
20371377-1	2010	P300/CBP associated factor (PCAF) acts as an acetyltransferase that acetylates specific lysine residues in histones, thereby remodelling chromatin structure.	Lysine	88-94	K(lysine) acetyltransferase 2B	Mus musculus	28-32
7520669-2	1994	Using an immortalized human glomerular epithelial cell line (E71-A1), we found a specific, saturable, and reversible binding of 125I-labeled plasminogen and 125I-labeled plasmin to HGEC that involved the lysine binding sites of both ligands.	Lysine	204-210	plasminogen	Homo sapiens	141-148
12794086-8	2003	Mass spectrometric analysis of mono-ubiquitinated Smad4 MH2 domain identified lysine 507 as a major target for ubiquitination.	Lysine	78-84	SMAD family member 4	Homo sapiens	50-55
20377204-6	2010	To determine the protein domains that are involved in the putative conformational change, full-length Ape1 protein was probed with a lysine-reactive reagent (NHS-biotin) in the context of free protein and DNA-bound complexes.	Lysine	133-139	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	102-106
12794086-9	2003	Lysine 507 resides in the conserved L3 loop of Smad4 and participates in R-Smad C-terminal phosphoserine recognition.	Lysine	0-6	SMAD family member 4	Homo sapiens	47-52
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Lysine	110-116	origin recognition complex subunit 2	Homo sapiens	0-4
12807890-4	2003	ORC2 has a broader specificity than ORC1, and L- and D-histidine, L-homoarginine, and D-isomers of ornithine, lysine, and ornithine are all substrates.	Lysine	110-116	origin recognition complex subunit 1	Homo sapiens	36-40
8049196-5	1994	Ligand studies revealed that the foam cell receptor activity recognizes Lp(a) containing both small and large isoforms of apo(a) as well as rhesus monkey Lp(a), which contains an inactive kringle-4(37) (K4(37) lysine-binding domain.	Lysine	210-216	apolipoprotein(a)	Macaca mulatta	154-159
7815475-6	1994	The NGF triple mutant Lys-32/Lys-34/Glu-35 to Ala, which has been demonstrated to bind to p140trkA, but not to p75NGFR, induced tyrosine phosphorylation more rapidly than wild-type NGF.	Lysine	22-25	nerve growth factor	Rattus norvegicus	4-7
7815475-6	1994	The NGF triple mutant Lys-32/Lys-34/Glu-35 to Ala, which has been demonstrated to bind to p140trkA, but not to p75NGFR, induced tyrosine phosphorylation more rapidly than wild-type NGF.	Lysine	29-32	nerve growth factor	Rattus norvegicus	4-7
20377204-7	2010	Protection patterns between pre- and postincision complexes revealed an increased susceptibility of lysine residues localized on the Ape1 surface that contacts the 3" end of the incised duplex (downstream of the incision site).	Lysine	100-106	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	133-137
20377204-11	2010	The reactivity of these Ref1 lysines was restored in the postincision complex.	Lysine	29-36	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	24-28
20377204-12	2010	The differential protection patterns of lysines in the flexible N-terminal domain suggest a novel Ref1 conformational change concomitant with DNA binding and catalysis.	Lysine	40-47	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	98-102
20546397-4	2010	Both factors potentially impact the availability of reactive lysine/glutaminyl residues required for TGase reactivity.	Lysine	61-67	transglutaminase 1	Homo sapiens	101-106
7909555-6	1994	Nevertheless, (+)-flesinoxan and LY 165,163 mimicked 8-OH-DPAT and WY 48,723 in eliciting a pronounced rise in plasma corticosterone and a marked hypothermia: these actions were blocked by the 5-HT1A receptor antagonist, (-)-alprenolol, but they were not affected by the alpha 1-antagonist prazosin.	Lysine	33-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	193-199
7909555-11	1994	STFs elicited by (+)-flesinoxan and LY 165,163 in the presence of cirazoline or ST 587 were blocked not only by prazosin but also by (-)-alprenolol, BMY 7378 and S 15535, all of which are antagonists of postsynaptic 5-HT1A receptors.	Lysine	36-38	5-hydroxytryptamine receptor 1A	Rattus norvegicus	216-222
7909555-13	1994	In conclusion, in the STF paradigm, the high-efficacy agonist actions of (+)-flesinoxan and LY 165,163 at 5-HT1A receptors are "masked" by their "intrinsic" alpha 1A-antagonist properties, the neutralization of which by alpha 1-agonists reveals the activation of 5-HT1A receptors.	Lysine	92-94	5-hydroxytryptamine receptor 1A	Rattus norvegicus	106-112
7909555-13	1994	In conclusion, in the STF paradigm, the high-efficacy agonist actions of (+)-flesinoxan and LY 165,163 at 5-HT1A receptors are "masked" by their "intrinsic" alpha 1A-antagonist properties, the neutralization of which by alpha 1-agonists reveals the activation of 5-HT1A receptors.	Lysine	92-94	5-hydroxytryptamine receptor 1A	Rattus norvegicus	263-269
12810706-3	2003	This conjugation is dependent on the integrity of the extreme N terminus of C/EBP beta-1 and requires lysine 173 in the human protein.	Lysine	102-108	CCAAT enhancer binding protein beta	Homo sapiens	76-86
12810706-4	2003	Furthermore, mutation of this lysine relieves the repression of the cyclin D1 promoter by C/EBP beta-1 without altering the subnuclear localization of C/EBP beta-1.	Lysine	30-36	cyclin D1	Homo sapiens	68-77
12810706-4	2003	Furthermore, mutation of this lysine relieves the repression of the cyclin D1 promoter by C/EBP beta-1 without altering the subnuclear localization of C/EBP beta-1.	Lysine	30-36	CCAAT enhancer binding protein beta	Homo sapiens	90-100
20150217-0	2010	Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.	Lysine	165-168	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	60-65
12740394-8	2003	The essential site for the distinct post-translation modification of MAP1LC3B is Lys-122 rather than the conserved Gly-120.	Lysine	81-84	microtubule associated protein 1 light chain 3 beta	Homo sapiens	69-77
12759363-6	2003	At a low concentration, DEN1 processes hyper-neddylated CUL1 to yield a mononeddylated form, which presumably contains the Lys-720CUL1-Nedd8 linkage.	Lysine	123-126	SUMO peptidase family member, NEDD8 specific	Homo sapiens	24-28
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Lysine	142-145	furin (paired basic amino acid cleaving enzyme)	Mus musculus	192-197
7907550-1	1994	Lysine-rich phosphorylated cystatin alpha (P-cystatin alpha) from newborn rat epidermis is a good substrate for epidermal transglutaminase (TGase) and also one of the component proteins of cornified envelope in the stratum corneum.	Lysine	0-6	stefin A3	Rattus norvegicus	27-41
7907550-1	1994	Lysine-rich phosphorylated cystatin alpha (P-cystatin alpha) from newborn rat epidermis is a good substrate for epidermal transglutaminase (TGase) and also one of the component proteins of cornified envelope in the stratum corneum.	Lysine	0-6	stefin A3	Rattus norvegicus	45-59
12759363-6	2003	At a low concentration, DEN1 processes hyper-neddylated CUL1 to yield a mononeddylated form, which presumably contains the Lys-720CUL1-Nedd8 linkage.	Lysine	123-126	cullin 1	Homo sapiens	56-60
12759363-6	2003	At a low concentration, DEN1 processes hyper-neddylated CUL1 to yield a mononeddylated form, which presumably contains the Lys-720CUL1-Nedd8 linkage.	Lysine	123-126	cullin 1	Homo sapiens	130-134
20150217-0	2010	Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.	Lysine	176-179	SUZ12 polycomb repressive complex 2 subunit	Mus musculus	60-65
12759363-6	2003	At a low concentration, DEN1 processes hyper-neddylated CUL1 to yield a mononeddylated form, which presumably contains the Lys-720CUL1-Nedd8 linkage.	Lysine	123-126	NEDD8 ubiquitin like modifier	Homo sapiens	135-140
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	38-44	RELA proto-oncogene, NF-kB subunit	Homo sapiens	52-56
12759363-8	2003	These activities distinguish DEN1 from the COP9 signalosome, which is capable of efficiently cleaving the Lys-720CUL1-Nedd8 conjugate, but lacks Nedd8 C-terminal hydrolytic activity and poorly processes hyperneddylated CUL1.	Lysine	106-109	SUMO peptidase family member, NEDD8 specific	Homo sapiens	29-33
12759363-8	2003	These activities distinguish DEN1 from the COP9 signalosome, which is capable of efficiently cleaving the Lys-720CUL1-Nedd8 conjugate, but lacks Nedd8 C-terminal hydrolytic activity and poorly processes hyperneddylated CUL1.	Lysine	106-109	cullin 1	Homo sapiens	113-117
8125959-11	1994	The cumulative data suggested that cadaverine formation may be caused by the action of intracellular ornithine decarboxylase upon lysine to produce cadaverine, which is then effluxed from the cell with a high degree of efficiency.	Lysine	130-136	ornithine decarboxylase 1	Homo sapiens	101-124
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	38-44	RELA proto-oncogene, NF-kB subunit	Homo sapiens	201-205
8119975-0	1994	A dual role for COOH-terminal lysine residues in pre-Golgi retention and endocytosis of ERGIC-53.	Lysine	30-36	lectin, mannose binding 1	Homo sapiens	88-96
8119975-3	1994	Cell surface ERGIC-53 is efficiently endocytosed by a mechanism that is disturbed when the two critical lysines of the endoplasmic reticulum retention motif are replaced by serines.	Lysine	104-111	lectin, mannose binding 1	Homo sapiens	13-21
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	98-105	RELA proto-oncogene, NF-kB subunit	Homo sapiens	52-56
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	98-105	RELA proto-oncogene, NF-kB subunit	Homo sapiens	201-205
8106489-7	1994	pH titration experiments showed that epsilon-NH2 group of Lys-115 has a normal pKa value both in the apo and Ca2+ forms of the protein and in a complex of calmodulin with a 22-residue calmodulin-binding peptide derived from myosin light chain kinase.	Lysine	58-61	myosin light chain kinase, smooth muscle	Bos taurus	224-249
20160011-5	2010	Conversely, enhancing the acetylation of lysine 310 by depleting SIRT1 or by replacing lysine 310 with acetyl-mimetic glutamine inhibits methylation, thereby decreasing ubiquitination, prolonging the stability of chromatin-associated RelA, and enhancing the transcriptional activity of NF-kappaB.	Lysine	41-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	234-238
12872131-6	2003	Finally, ubiquitin itself was found to be modified at seven lysine residues providing evidence for unexpected diversity in polyubiquitin chain topology in vivo.	Lysine	60-66	ubiquitin	Saccharomyces cerevisiae S288C	9-18
20160011-6	2010	The acetylation of lysine 310 of RelA interferes with its interaction with Set9.	Lysine	19-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	33-37
20160011-7	2010	Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positive charge of lysine 310 is critical for the binding of RelA to a negatively charged "exosite" within the SET domain of Set9.	Lysine	105-111	RELA proto-oncogene, NF-kB subunit	Homo sapiens	60-64
20160011-7	2010	Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positive charge of lysine 310 is critical for the binding of RelA to a negatively charged "exosite" within the SET domain of Set9.	Lysine	105-111	RELA proto-oncogene, NF-kB subunit	Homo sapiens	147-151
8155080-1	1994	The effect of L-lysine on some reactions catalysed by plasmin and the plasmin-streptokinase activator complex has been studied.	Lysine	14-22	plasminogen	Homo sapiens	70-77
20160011-8	2010	Together, these findings demonstrate for the first time an interplay between RelA acetylation and methylation and also provide a novel mechanism for the regulation of lysine methylation by acetylation.	Lysine	167-173	RELA proto-oncogene, NF-kB subunit	Homo sapiens	77-81
8155080-2	1994	The constants for competitive inhibition by L-lysine of the benzyloxycarbonyl-L-lysine p-nitrophenyl ester hydrolysis by the activator (Ki 116 mM), of the plasminogen activation by the activator (Ki 8 mM) and of fibrinolysis by plasmin (Ki 3 mM) were determined.	Lysine	44-52	plasminogen	Homo sapiens	155-162
8155080-3	1994	It was found that L-lysine at concentrations below 0.05 M, which do not affect the activator"s esterase activity, does inhibit fibrinolysis by plasmin and the activator complex.	Lysine	18-26	plasminogen	Homo sapiens	143-150
12892891-0	2003	Molecular characterization of the Candida albicans LYS5 gene and site-directed mutational analysis of the PPTase (Lys5p) domains for lysine biosynthesis.	Lysine	133-139	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	114-119
8155080-4	1994	The effect of L-lysine on fibrinolysis under the action of the activator is complex: it inhibits both the activation of clot-entrapped plasminogen by the activator and lysis of fibrin by the plasmin formed.	Lysine	14-22	plasminogen	Homo sapiens	135-142
12892891-1	2003	The LYS2 and LYS5 genes of the pathogenic yeast Candida albicans are required for the alpha-aminoadipate reductase (AAR) reaction in the lysine biosynthetic pathway.	Lysine	137-143	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	4-8
20567762-1	2010	Methylation of lysine residues, catalyzed by histone methyltransferase (HMT) enzymes, is one of many modifications of core histone proteins that regulate transcription and chromatin structure.	Lysine	15-21	PR/SET domain 9	Homo sapiens	45-70
12892891-1	2003	The LYS2 and LYS5 genes of the pathogenic yeast Candida albicans are required for the alpha-aminoadipate reductase (AAR) reaction in the lysine biosynthetic pathway.	Lysine	137-143	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	13-17
8155080-5	1994	This inhibitory action of L-lysine is largely related to the fact that it lowers the sorption of the activator, plasminogen and plasmin on fibrin, competing with fibrin for their lysine-binding sites as well as worsens the activator-plasminogen binding.	Lysine	26-34	plasminogen	Homo sapiens	112-119
20140018-0	2010	Lysine methylation regulates the pRb tumour suppressor protein.	Lysine	0-6	RB transcriptional corepressor 1	Homo sapiens	33-36
12758070-4	2003	We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	22-26
20140018-3	2010	We describe here a new level of regulation on pRb, mediated through the targeted methylation of lysine residues, by the methyltransferase Set7/9.	Lysine	96-102	RB transcriptional corepressor 1	Homo sapiens	46-49
12637496-2	2003	We have studied the role of a highly conserved serine residue in the fifth transmembrane segment of the Na,K-ATPase, which is replaced with a lysine in all known H,K-ATPases.	Lysine	142-148	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	107-115
20346720-2	2010	Here, we show that the XLMR protein PHF8 and a C. elegans homolog F29B9.2 catalyze demethylation of di- and monomethylated lysine 9 of histone H3 (H3K9me2/me1).	Lysine	123-129	PHD finger protein 8	Homo sapiens	36-40
12769850-5	2003	We show that interaction of MOF with MSL-3 leads to specific acetylation of MSL-3 at a single lysine residue adjacent to one of its chromodomains.	Lysine	94-100	male-specific lethal 3	Drosophila melanogaster	37-42
20048150-7	2010	Using BMP-6/7 chimeras, we identified lysine 60 as a key residue conferring noggin resistance within the BMP-6 protein.	Lysine	38-44	noggin	Homo sapiens	76-82
12769850-5	2003	We show that interaction of MOF with MSL-3 leads to specific acetylation of MSL-3 at a single lysine residue adjacent to one of its chromodomains.	Lysine	94-100	male-specific lethal 3	Drosophila melanogaster	76-81
12769861-3	2003	SUMOylation occurred at a single Lys residue, Lys428, of CtBP1.	Lysine	33-36	C-terminal binding protein 1	Homo sapiens	57-62
20048150-8	2010	A remarkable correlation was found between the presence of a lysine at this position and noggin resistance among a panel of osteoinductive BMPs.	Lysine	61-67	noggin	Homo sapiens	89-95
20048150-9	2010	Introduction of a lysine residue at the corresponding positions of BMP-2 and BMP-7 allowed for molecular engineering of recombinant BMPs with increased resistance to noggin antagonism.	Lysine	18-24	bone morphogenetic protein 2	Homo sapiens	67-72
20048150-9	2010	Introduction of a lysine residue at the corresponding positions of BMP-2 and BMP-7 allowed for molecular engineering of recombinant BMPs with increased resistance to noggin antagonism.	Lysine	18-24	noggin	Homo sapiens	166-172
20348416-4	2010	We show that the molecular mechanism of TBR1 suppression is based on the interaction of AF9 with DOT1L, a protein that mediates transcriptional control through methylation of histone H3 lysine 79 (H3K79).	Lysine	186-192	T-box brain transcription factor 1	Mus musculus	40-44
20079884-3	2010	Earlier work had suggested that lysine might function as a recognition molecule for SSAO/VAP-1.	Lysine	32-38	amine oxidase copper containing 3	Homo sapiens	84-88
20079884-3	2010	Earlier work had suggested that lysine might function as a recognition molecule for SSAO/VAP-1.	Lysine	32-38	amine oxidase copper containing 3	Homo sapiens	89-94
20079884-4	2010	The present work reports the kinetics of the interaction of L-lysine and some of its derivatives with SSAO.	Lysine	60-68	amine oxidase copper containing 3	Homo sapiens	102-106
20236312-1	2010	The fourth lysine of histone H3 is post-translationally modified by a methyl group via the action of histone methyltransferase, and such a covalent modification is associated with transcriptionally active and/or repressed chromatin states.	Lysine	11-17	PR/SET domain 9	Homo sapiens	101-126
20071582-3	2010	Upon the recognition of viral RNA, the Lys-172 residue of RIG-I undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction.	Lysine	39-42	tripartite motif containing 25	Homo sapiens	100-127
20071582-3	2010	Upon the recognition of viral RNA, the Lys-172 residue of RIG-I undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction.	Lysine	39-42	tripartite motif containing 25	Homo sapiens	129-135
20086098-7	2010	The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro.	Lysine	82-88	AT-rich interaction domain 1B	Homo sapiens	19-26
12667482-8	2003	The affinity and kinetics of copper binding to 17K r-apo(a) are diminished in the presence of the lysine analogue epsilon -aminocaproic acid.	Lysine	98-104	lipoprotein(a)	Homo sapiens	53-59
8155080-5	1994	This inhibitory action of L-lysine is largely related to the fact that it lowers the sorption of the activator, plasminogen and plasmin on fibrin, competing with fibrin for their lysine-binding sites as well as worsens the activator-plasminogen binding.	Lysine	28-34	plasminogen	Homo sapiens	112-119
20354225-2	2010	We found that NUAK1 interacts with several myosin phosphatases, including the myosin phosphatase targeting-1 (MYPT1)-protein phosphatase-1beta (PP1beta) complex, through conserved Gly-Ile-Leu-Lys motifs that are direct binding sites for PP1beta.	Lysine	192-195	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	78-108
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Lysine	27-33	zinc fingers and homeoboxes 2	Homo sapiens	160-163
8187245-5	1994	Somewhat unexpectedly, the negative groups of the kringle correspond to an enlarged anionic center of the lysine binding site of lysine binding kringles such as plasminogen K1 and K4 and TPA K2.	Lysine	106-112	keratin 1	Homo sapiens	173-193
8187245-5	1994	Somewhat unexpectedly, the negative groups of the kringle correspond to an enlarged anionic center of the lysine binding site of lysine binding kringles such as plasminogen K1 and K4 and TPA K2.	Lysine	129-135	keratin 1	Homo sapiens	173-193
12501250-5	2003	Further, p53 trans-activation of the 14-3-3varsigma promoter was markedly repressed by Tat-histone acetyltransferase interactions, and p53 acetylation by p300/CREB-binding protein-associated factor on residue Lys(320) was diminished as a result of Tat-histone acetyltransferase binding in vivo and in vitro.	Lysine	209-212	E1A binding protein p300	Homo sapiens	154-158
12529333-3	2003	PR undergoes a sumoylation at lysine 388 located in its N-terminal domain.	Lysine	30-36	progesterone receptor	Homo sapiens	0-2
20354225-2	2010	We found that NUAK1 interacts with several myosin phosphatases, including the myosin phosphatase targeting-1 (MYPT1)-protein phosphatase-1beta (PP1beta) complex, through conserved Gly-Ile-Leu-Lys motifs that are direct binding sites for PP1beta.	Lysine	192-195	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	110-115
12665592-5	2003	Sumoylation is rapidly and transiently enhanced on lysine 298, located in the regulatory domain of HSF1, adjacent to several critical phosphorylation sites.	Lysine	51-57	heat shock transcription factor 1	Homo sapiens	99-103
20354225-2	2010	We found that NUAK1 interacts with several myosin phosphatases, including the myosin phosphatase targeting-1 (MYPT1)-protein phosphatase-1beta (PP1beta) complex, through conserved Gly-Ile-Leu-Lys motifs that are direct binding sites for PP1beta.	Lysine	192-195	protein phosphatase 1 catalytic subunit beta	Homo sapiens	144-151
20064925-9	2010	Moreover, we demonstrated that the dynamic pattern of lysine 27 trimethylation of histone 3 was conferred by the interplay of SUZ12 and JMJD3, both of which were involved in maintaining hESC pluripotency.	Lysine	54-60	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	126-131
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Lysine	47-50	vascular endothelial growth factor A	Gallus gallus	150-184
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Lysine	47-50	vascular endothelial growth factor A	Gallus gallus	186-190
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Lysine	276-279	serpin family F member 1	Homo sapiens	145-149
12641448-1	2003	The small ubiquitin-like modifier SUMO-1 is covalently attached to lysine residues on target proteins by a specific conjugation pathway involving the E1 enzyme SAE1/SAE2 and the E2 enzyme Ubc9.	Lysine	67-73	small ubiquitin like modifier 1	Homo sapiens	34-40
7508380-1	1994	Furin is a membrane-associated endoprotease that efficiently cleaves precursor proteins on the C-terminal side of the consensus sequence, Arg-X-Lys/Arg-Arg1, and has been proposed to catalyze these reactions in both exocytic and endocytic compartments.	Lysine	143-147	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7581746-2	1994	Both purified enzymes hydrolyse HHL in a radiochemical assay with the same optimal pH, a characteristic divalent metal requirement, a close similar behavior against inhibitors of other metallopeptidases, such as enkephalinase and kininase I, and the involvement of arginine and lysine residues in their active site.	Lysine	278-284	hes family bHLH transcription factor 1	Homo sapiens	32-35
20300531-5	2010	Here we report that PIASy, a SUMO E3 ligase upregulated in hypoxia, interacts with VHL and induces VHL SUMOylation on lysine residue 171.	Lysine	118-124	von Hippel-Lindau tumor suppressor	Homo sapiens	99-102
8188615-1	1994	The active-site lysine residue of thermostable aspartate aminotransferase, Lys-239, to which the cofactor, pyridoxal 5"-phosphate (PLP), is bound, has been converted to Cys by site-directed mutagenesis.	Lysine	16-22	pyridoxal phosphatase	Homo sapiens	131-134
8188615-1	1994	The active-site lysine residue of thermostable aspartate aminotransferase, Lys-239, to which the cofactor, pyridoxal 5"-phosphate (PLP), is bound, has been converted to Cys by site-directed mutagenesis.	Lysine	75-78	pyridoxal phosphatase	Homo sapiens	131-134
12511561-1	2003	The histone methyltransferase Set2, which specifically methylates lysine 36 of histone H3, has been shown to repress transcription upon tethering to a heterologous promoter.	Lysine	66-72	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	30-34
20071328-7	2010	The principal protease in milk, plasmin, hydrolyzed the same peptide bond as thrombin, but its main cleavage site was identified to be Lys(154)-Ser(155).	Lysine	135-138	plasminogen	Homo sapiens	32-39
12522143-8	2003	Competition studies using synthetic peptides suggested that LRP binding involves the FVIII-specific region Lys(1804)-Ala(1834) in the A3 domain.	Lysine	107-110	coagulation factor VIII	Homo sapiens	85-90
12522143-9	2003	In line with this observation, LRP binding was inhibited by a recombinant antibody fragment that specifically binds to the FVIII sequence Glu(1811)-Lys(1818).	Lysine	148-151	coagulation factor VIII	Homo sapiens	123-128
12522143-12	2003	This suggests that multiple sites in FVIII contribute to high-affinity LRP binding, one of which is the FVIII A3 domain region Glu(1811)-Lys(1818).	Lysine	137-140	coagulation factor VIII	Homo sapiens	37-42
12522143-12	2003	This suggests that multiple sites in FVIII contribute to high-affinity LRP binding, one of which is the FVIII A3 domain region Glu(1811)-Lys(1818).	Lysine	137-140	coagulation factor VIII	Homo sapiens	104-109
7991457-0	1994	Isolation of a novel peptide with a unique binding profile from human brain cortex: Tyr-K-MIF-1 (Tyr-Pro-Lys-Gly-NH2).	Lysine	105-108	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	90-95
8257702-0	1993	Comparison of the lysine binding functions of lipoprotein(a) and plasminogen.	Lysine	18-24	lipoprotein(a)	Homo sapiens	46-60
8257702-3	1993	In the current study, the lysine binding properties of Lp(a) have been compared to those of plasminogen and isolated kringle 4 of plasminogen (K4).	Lysine	26-32	lipoprotein(a)	Homo sapiens	55-60
19996088-3	2010	First, we demonstrate that, despite impaired binding of Glu-plasminogen to the cell membrane by epsilon-aminocaproic acid (epsilon-ACA) or by a lysine-binding site-specific mAb, plasmin is unexpectedly formed by cell-associated urokinase (uPA).	Lysine	144-150	plasminogen	Homo sapiens	60-67
8257702-5	1993	Radioiodinated ligands, Lp(a), plasminogen, and K4, bound to the beads, and their interactions were inhibited by lysine analogues in a dose-dependent fashion.	Lysine	113-119	lipoprotein(a)	Homo sapiens	24-29
8257702-6	1993	A series of omega-aminocarboxylic acids inhibited Lp(a), plasminogen, and K4 binding to the lysine-Sepharose beads, but marked differences in the effectiveness of these compounds were observed with each ligand.	Lysine	92-98	lipoprotein(a)	Homo sapiens	50-55
8257702-12	1993	These results suggest that the kringles of Lp(a) possess lysine binding functions which are similar, but not identical, to those of plasminogen and its K4.	Lysine	57-63	lipoprotein(a)	Homo sapiens	43-48
12708312-2	2003	Enteropeptidase (enterokinase, EC 3.4.21.9) hydrolyzes peptide bonds formed by carboxyl groups of Lys or Arg residue provided that less than four negatively charged amino acid residues are in positions P2-P5 of its substrate.	Lysine	98-101	transmembrane serine protease 15	Homo sapiens	0-15
12685035-2	2003	The deduced polypeptide WDHN 13 (MW = 12.8 kDa) represented the smallest dehydrin member in cereals with three lysine-rich K-segments.	Lysine	111-117	cold-shock protein CS120-like	Triticum aestivum	24-31
19996088-4	2010	Second, we show that Glu-plasminogen bound to carboxy-terminal lysine residues in platelets, fibrin, or extracellular matrix components (fibronectin, laminin) is transformed into plasmin by uPA expressed on monocytes or endothelial cell-derived microparticles but not by tissue-type plasminogen activator (tPA) expressed on neurons.	Lysine	63-69	plasminogen	Homo sapiens	25-32
8268211-0	1993	Evidence for proximal cysteine and lysine residues present at the nucleotide domain of rabbit muscle creatine kinase.	Lysine	35-41	creatine kinase M-type	Oryctolagus cuniculus	94-116
20026029-1	2010	Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysines in carboxylases and histones in two steps.	Lysine	68-75	holocarboxylase synthetase	Homo sapiens	0-26
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-6	apolipoprotein E	Canis lupus familiaris	25-47
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-6	apolipoprotein E	Canis lupus familiaris	87-91
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-6	low density lipoprotein receptor	Canis lupus familiaris	123-161
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-3	apolipoprotein E	Canis lupus familiaris	25-47
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-3	apolipoprotein E	Canis lupus familiaris	87-91
12401518-2	2003	In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity.	Lysine	146-148	protein kinase C beta	Homo sapiens	128-135
8226815-1	1993	Lysine (Lys) residues in apolipoprotein (apo) E are known to be involved in binding of apoE-containing lipoproteins to the low density lipoprotein (LDL) receptor.	Lysine	0-3	low density lipoprotein receptor	Canis lupus familiaris	123-161
20026029-1	2010	Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysines in carboxylases and histones in two steps.	Lysine	68-75	holocarboxylase synthetase	Homo sapiens	28-31
8226815-2	1993	To examine the microenvironments of the Lys residues of apoE-3 in a variety of lipid-associated states, we have used a high resolution 13C-NMR method in which Lys were reductively methylated with [13C] formaldehyde.	Lysine	40-43	apolipoprotein E	Canis lupus familiaris	56-60
8226815-2	1993	To examine the microenvironments of the Lys residues of apoE-3 in a variety of lipid-associated states, we have used a high resolution 13C-NMR method in which Lys were reductively methylated with [13C] formaldehyde.	Lysine	159-162	apolipoprotein E	Canis lupus familiaris	56-60
8226815-3	1993	Over a wide pH range, the spectrum of apoE in canine HDLc, a spherical lipoprotein particle, exhibited two peaks from Lys epsilon-amino groups.	Lysine	118-121	apolipoprotein E	Canis lupus familiaris	38-42
12559117-5	2003	Moreover, blockade of both mGluR1 and mGluR5 by LY 367385 and MPEP co-administration fully suppresses LTP.	Lysine	48-50	glutamate receptor, ionotropic, kainate 1	Mus musculus	38-44
12374802-7	2002	However, a mutant that cannot be acetylated by PCAF due to a change in the surrounding amino acid context of lysine 92 showed increased DNA binding and activity compared with wild type IRF7.	Lysine	109-115	lysine acetyltransferase 2B	Homo sapiens	47-51
8226815-6	1993	A single Lys microenvironment was observed for apoE present in a disordered, lipid-free, state in 8 M urea, confirming the fact that the lipid environment is modulating the conformation of apoE.	Lysine	9-12	apolipoprotein E	Canis lupus familiaris	47-51
20026029-2	2010	First, HCS catalyzes the synthesis of biotinyl-5"-AMP; second, the biotinyl moiety is ligated to lysine residues.	Lysine	97-103	holocarboxylase synthetase	Homo sapiens	7-10
8226815-6	1993	A single Lys microenvironment was observed for apoE present in a disordered, lipid-free, state in 8 M urea, confirming the fact that the lipid environment is modulating the conformation of apoE.	Lysine	9-12	apolipoprotein E	Canis lupus familiaris	189-193
8226815-7	1993	The above data demonstrate that the conformation of apoE, as reflected by the Lys microenvironments, on spherical HDLc particles is different from that on discoidal complexes.	Lysine	78-81	apolipoprotein E	Canis lupus familiaris	52-56
20026029-6	2010	A potential target lysine in Syn67 was biotinylated by HCS only after arginine-to-glycine substitutions in Syn67 produced a histone-like peptide.	Lysine	19-25	holocarboxylase synthetase	Homo sapiens	55-58
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	145-151	lipoprotein(a)	Homo sapiens	69-86
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	145-151	lipoprotein(a)	Homo sapiens	72-86
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	145-151	lipoprotein(a)	Homo sapiens	125-130
20113253-2	2010	Results of in vitro studies demonstrated that fibrinogen can bind to apolipoprotein(a) [apo(a)] component of lipoprotein(a) [Lp(a)] through both lysine-sensitive and lysine-insensitive mechanisms.	Lysine	166-172	lipoprotein(a)	Homo sapiens	69-86
8232556-6	1993	A lysine to arginine substitution at the corresponding residue of BRG1 also generated a transcriptional dominant negative in human cells.	Lysine	2-8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	66-70
20077120-8	2010	In XS52 cells, which express TLR2, TLR3, TLR4, and TLR7, but not TLR9, expression of claudin-7 protein was also increased after treatment with ligands of TLR2, TLR4 or TLR7/8, Pam3Cys-Ser-(Lys)4, LPS, or CL097.	Lysine	189-192	toll-like receptor 2	Mus musculus	29-33
8399241-5	1993	The structural changes are assumed to be induced by the electrostatic interactions between the negatively charged binding domain on cytochrome c oxidase and the positively charged lysine residues on the front surface of cytochrome c.	Lysine	180-186	LOC104968582	Bos taurus	132-144
8399241-8	1993	However, the analysis of the spectra suggests that lysine-79 may be involved in controlling conformational details within the heme pocket of the bound cytochrome c.	Lysine	51-57	LOC104968582	Bos taurus	151-163
12464276-4	2002	Surface plasmon resonance (SPR) analysis showed that CaMKIV(T196D), which mimics CaMKPase substrate, and CaMKPase could form tight complexes with poly(Lys).	Lysine	151-155	calcium/calmodulin dependent protein kinase IV	Homo sapiens	53-59
12464276-5	2002	Pull-down binding experiments suggested that the formation of a tightly associated ternary complex consisting of CaMKPase, poly(Lys), and phosphorylated CaMKIV is essential for stimulation.	Lysine	128-131	calcium/calmodulin dependent protein kinase IV	Homo sapiens	153-159
12457458-7	2002	The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT(2A+2C) antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT(3+4) antagonist ICS-205930 (ICS), whereas the 5-HT(1A) antagonist WAY-100635 (WAY) had no effect.	Lysine	126-128	5-hydroxytryptamine receptor 2A	Rattus norvegicus	81-88
20077120-8	2010	In XS52 cells, which express TLR2, TLR3, TLR4, and TLR7, but not TLR9, expression of claudin-7 protein was also increased after treatment with ligands of TLR2, TLR4 or TLR7/8, Pam3Cys-Ser-(Lys)4, LPS, or CL097.	Lysine	189-192	toll-like receptor 2	Mus musculus	154-158
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Lysine	109-112	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
20067792-2	2010	The PHF8 active site is highly conserved with those of the FBXL10/11demethylases, which are also selective for the di-/mono-methylated lysine states, but differs from that of the JMJD2 demethylases which are selective for tri-/di-methylated states.	Lysine	135-141	PHD finger protein 8	Homo sapiens	4-8
8243983-1	1993	Amplification of the LYP1 transport system in the plasma membrane of Saccharomyces cerevisiae did not change the substrate specificity, the affinity and the pH optimum of the transport system for lysine, but significantly increased the uptake velocity and accumulation ratio.	Lysine	196-202	lysine permease	Saccharomyces cerevisiae S288C	21-25
20018852-10	2010	Although MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8.	Lysine	84-90	lysine acetyltransferase 8	Homo sapiens	24-27
12434058-2	2002	We now demonstrate that Hos2, another member of the class I family, binds to the coding regions of genes primarily during gene activation, when it specifically deacetylates the lysines in H3 and H4 histone tails.	Lysine	177-184	histone deacetylase HOS2	Saccharomyces cerevisiae S288C	24-28
12698555-2	2002	Catalyzing trypsinogen activation enteropeptidase exhibits unique properties for high efficiency hydrolysis of the polypeptide chain after lysine-15 residue in the -DDDDK15- sequence.	Lysine	139-145	transmembrane serine protease 15	Homo sapiens	34-49
20018852-10	2010	Although MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8.	Lysine	191-198	lysine acetyltransferase 8	Homo sapiens	110-113
12698555-3	2002	In 1998 we found an unusual calcium-dependent autolysis of the enteropeptidase heavy chain leading to the drastic loss of its activity towards trypsinogen: after lysine-360 (-NNYEK360-INCN-), -), arginine-384 (-NEWER384-TQGS-), arginine-422 (-GRRER422-VGLL-) and lysine-465 (-QNMEK465-TIFQ-) residues.	Lysine	162-168	transmembrane serine protease 15	Homo sapiens	63-78
12698555-3	2002	In 1998 we found an unusual calcium-dependent autolysis of the enteropeptidase heavy chain leading to the drastic loss of its activity towards trypsinogen: after lysine-360 (-NNYEK360-INCN-), -), arginine-384 (-NEWER384-TQGS-), arginine-422 (-GRRER422-VGLL-) and lysine-465 (-QNMEK465-TIFQ-) residues.	Lysine	263-269	transmembrane serine protease 15	Homo sapiens	63-78
7690548-1	1993	Furin has been proposed to be the endoprotease responsible for precursor cleavage at Arg-X-Lys/Arg-Arg (RXK/RR) sites within the constitutive secretory pathway.	Lysine	91-94	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
20044541-4	2010	The involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes but raises questions about what forces have driven such rapid change.	Lysine	50-56	PR/SET domain 9	Homo sapiens	19-24
8369283-5	1993	It was established that E. coli harboring the mutant plasmid pKGP-HA1mut4 and an inactive pCM-X# are chloramphenicol-resistant and that the mutation responsible for the expression of CAT from the inactive pCM-X# plasmid is a G to A transition at nucleotide 664 of T7 gene 1 that converts glutamic acid (222) to lysine.	Lysine	311-317	chloramphenicol acetyltransferase	Escherichia coli	183-186
12408863-4	2002	The lysine 9 position is trimethylated and this mark is closely associated with Polycomb binding sites on polytene chromosomes but is also found in centric heterochromatin, chromosome 4, and telomeric sites.	Lysine	4-10	Polycomb	Drosophila melanogaster	80-88
20101266-4	2010	Biochemical and structural studies reveal that PHF8 is a novel histone demethylase specific for di- and mono-methylated histone H3 lysine 9 (H3K9me2/1), but not for H3K9me3.	Lysine	131-137	PHD finger protein 8	Homo sapiens	47-51
12161447-9	2002	Importantly, the RDM is similar to the recognition sequence for attachment of the ubiquitin-like protein, small ubiquitin-like modifier-1 (SUMO-1), and the conserved lysine residue of each C/EBP RDM served as an attachment site for SUMO-1.	Lysine	166-172	small ubiquitin like modifier 1	Homo sapiens	106-137
12161447-9	2002	Importantly, the RDM is similar to the recognition sequence for attachment of the ubiquitin-like protein, small ubiquitin-like modifier-1 (SUMO-1), and the conserved lysine residue of each C/EBP RDM served as an attachment site for SUMO-1.	Lysine	166-172	small ubiquitin like modifier 1	Homo sapiens	232-238
7689478-5	1993	This was considerably reduced by preincubation of the cells in lysine and an excess of cold nucleotides prior to the PRINS reaction.	Lysine	63-69	psoriasis associated non-protein coding RNA induced by stress	Homo sapiens	117-122
7694644-5	1993	We investigated this phenomenon further by using two analogues of Ac1-11 with alanine or tyrosine at position 4 which display higher affinity binding to the I-Au molecule than the original peptide with lysine at this position.	Lysine	202-208	adenylate cyclase 1	Mus musculus	66-69
19950192-0	2010	Epigenetic control of translation regulation: alterations in histone H3 lysine 9 post-translation modifications are correlated with the expression of the translation initiation factor 2B (Eif2b5) during thermal control establishment.	Lysine	72-78	eukaryotic translation initiation factor 2B subunit epsilon	Gallus gallus	188-194
8259556-4	1993	NH2-terminal amino acid sequence analysis revealed the sequence Lys-Gly-Asp- in addition to the known sequences of the Lys-plasmin chains, identifying STAR-delta 10 as the derivative generated from HMW-STAR.	Lysine	119-122	plasminogen	Homo sapiens	123-130
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18 binding protein	Homo sapiens	162-183
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18 binding protein	Homo sapiens	185-192
20010696-5	2010	Analysis of a single-copy gene, SUPPRESSOR OF drm1 drm2 cmt3 (SDC), revealed that mom1 activates SDC with concomitant reduction of di-methylated histone H3 lysine 9 (H3K9me2) at the tandem repeats in the promoter region without changes in siRNA accumulation and cytosine methylation.	Lysine	156-162	ascorbic acid mannose pathway regulator, putative (DUF295)	Arabidopsis thaliana	32-60
12241545-4	2002	Herein, we first determined that PAPP-A cleaves IGFBP-4 at a single site (Met-135/Lys-136), and we analysed the influence of ionic strength, pH and zinc ion concentration on the cleavage reaction.	Lysine	82-85	pappalysin 1	Homo sapiens	33-39
8395206-1	1993	The reactions of bovine cytochrome c oxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)bis(bipyridine)ruthenium (II) were studied by laser flash photolysis.	Lysine	101-107	LOC104968582	Bos taurus	24-36
8395206-4	1993	The photoreduced heme Fe(II) in the cytochrome c derivative modified at lysine 25 on the periphery of the heme crevice domain transferred an electron to CuA with a rate constant of 1.1 x 10(4) s-1.	Lysine	72-78	LOC104968582	Bos taurus	36-48
8395206-6	1993	The derivatives modified at lysines 7, 39, 55, and 60 remote from the heme crevice domain of cytochrome c have nearly the same kinetics.	Lysine	28-35	LOC104968582	Bos taurus	93-105
19843542-4	2010	PHF8 is selective in vitro for N(epsilon)-di- and mono-methylated lysine residues and does not accept trimethyl substrates.	Lysine	66-72	PHD finger protein 8	Homo sapiens	0-4
8395206-8	1993	The cytochrome c derivatives modified at lysines 13 and 27 in the heme crevice domain react much more slowly than the other derivatives, with intracomplex rate constants for oxidation of cytochrome c ranging from 1000 to 6000 s-1.	Lysine	41-48	LOC104968582	Bos taurus	4-16
8395206-8	1993	The cytochrome c derivatives modified at lysines 13 and 27 in the heme crevice domain react much more slowly than the other derivatives, with intracomplex rate constants for oxidation of cytochrome c ranging from 1000 to 6000 s-1.	Lysine	41-48	LOC104968582	Bos taurus	187-199
12110674-3	2002	A particular pair of HAT (Esa1) and HDAC (Rpd3) is proposed to modify the same lysine residue in vitro and in vivo.	Lysine	79-85	histone deacetylase 3	Homo sapiens	42-46
12119305-3	2002	The PDZKI-interacting domain on SR-BI was identified as the last three carboxyl-terminal amino acids, Arg-Lys-Leu.	Lysine	106-109	scavenger receptor class B, member 1	Mus musculus	32-37
8393577-5	1993	Electron density for the crystal structure of cathepsin D indicated the presence of an N-linked oligosaccharide that extends from Asn-70 toward Lys-203, which is a key component of the phosphotransferase recognition region, and thus provides a structural explanation for how the phosphotransferase can recognize apparently distant sites on the protein surface.	Lysine	144-147	cathepsin D	Homo sapiens	46-57
19966288-4	2010	This reaction leads to the poly-ubiquitination of p45/NF-E2 at one or more of six Lys residues, one of which being also a sumoylation site, and its degradation through the proteasome pathway.	Lysine	82-85	nuclear factor, erythroid derived 2	Mus musculus	50-53
12029097-2	2002	(125)I-YQLS or (125)I-YQS was cross-linked to CRFR1 using the chemical cross-linker, disuccinimidyl suberate (DSS), which cross-links the epsilon amino groups of lysine residues that have a molecular distance of 11.4 A.	Lysine	162-168	corticotropin releasing hormone receptor 1	Homo sapiens	46-51
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	40-46	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	57-60	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
8368011-5	1993	The strain transformed by a multi-copy plasmid harbouring the LYP1 gene, showed a 20-fold increase in the maximum velocity of lysine uptake over that in the wild type, with no changes in the affinity of the permease for its substrate.	Lysine	126-132	lysine permease	Saccharomyces cerevisiae S288C	62-66
19966288-4	2010	This reaction leads to the poly-ubiquitination of p45/NF-E2 at one or more of six Lys residues, one of which being also a sumoylation site, and its degradation through the proteasome pathway.	Lysine	82-85	nuclear factor, erythroid derived 2	Mus musculus	54-59
20564039-9	2010	The study shows that lysine 56 is a potential site to introduce labels site-specifically in SDF-1.	Lysine	21-27	C-X-C motif chemokine ligand 12	Homo sapiens	92-97
8506365-5	1993	One mutation changed a single nucleotide from A to G, resulting in substitution of Glu (GAA) for Lys-37 (AAA).	Lysine	97-100	alpha glucosidase	Homo sapiens	88-91
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	140-146	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
8098196-1	1993	The lysine residues at positions 194 and 198 in phenylalanine hydroxylase have been shown to react with a photoaffinity label which is an analog of phenyltetrahydropterin (Gibbs, B. S., and Benkovic, S. J.	Lysine	4-10	phenylalanine hydroxylase	Homo sapiens	48-73
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
19887446-5	2010	Our results show that a positively charged surface on NSF-N, bounded by Arg(67) and Lys(105), and the conserved residues in the central pore of NSF-D1 (Tyr(296) and Gly(298)) are involved in SNAP.SNARE binding but not basal ATP hydrolysis.	Lysine	84-87	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	54-57
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-4	2002	CRFR1 contains 5 putative extracellular lysine residues (Lys(110), Lys(111), Lys(113), Lys(257), and Lys(262)) that can cross-link to the 4 lysine residues (Lys(16), Lys(22), Lys(25), and Lys(27)) of the radioligands.	Lysine	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	0-5
12029097-5	2002	Identification of the CNBr-cleaved fragments of CRFR1 cross-linked to (125)I-YQLS or (125)I-YQS established that the second extracellular loop of CRFR1 cross-links to Lys(16) of YQS.	Lysine	167-170	corticotropin releasing hormone receptor 1	Homo sapiens	48-53
12029097-5	2002	Identification of the CNBr-cleaved fragments of CRFR1 cross-linked to (125)I-YQLS or (125)I-YQS established that the second extracellular loop of CRFR1 cross-links to Lys(16) of YQS.	Lysine	167-170	corticotropin releasing hormone receptor 1	Homo sapiens	146-151
12029097-6	2002	Additionally, site-directed mutagenesis (changing Lys to Arg in CRFR1 individually and in combination) revealed that Lys(257) in the second extracellular loop of CRFR1 is an important cross-linking site.	Lysine	50-53	corticotropin releasing hormone receptor 1	Homo sapiens	162-167
12029097-6	2002	Additionally, site-directed mutagenesis (changing Lys to Arg in CRFR1 individually and in combination) revealed that Lys(257) in the second extracellular loop of CRFR1 is an important cross-linking site.	Lysine	117-120	corticotropin releasing hormone receptor 1	Homo sapiens	64-69
12029097-6	2002	Additionally, site-directed mutagenesis (changing Lys to Arg in CRFR1 individually and in combination) revealed that Lys(257) in the second extracellular loop of CRFR1 is an important cross-linking site.	Lysine	117-120	corticotropin releasing hormone receptor 1	Homo sapiens	162-167
8098196-3	1993	The related enzyme tyrosine hydroxylase has a lysine at position 241 which, given the 75% identity between its C-terminal 330 amino acids and those of phenylalanine hydroxylase, corresponds to lysine194 of phenylalanine hydroxylase.	Lysine	46-52	phenylalanine hydroxylase	Homo sapiens	151-176
8098196-3	1993	The related enzyme tyrosine hydroxylase has a lysine at position 241 which, given the 75% identity between its C-terminal 330 amino acids and those of phenylalanine hydroxylase, corresponds to lysine194 of phenylalanine hydroxylase.	Lysine	46-52	phenylalanine hydroxylase	Homo sapiens	206-231
8318457-4	1993	A mutant IL-2 molecule, Lys-20 IL-2 which is known to be defective of p75 interaction, was unable to stimulate cells expressing only p75: p55 co-expression could restore its activity.	Lysine	24-27	interleukin 2 receptor subunit beta	Homo sapiens	70-73
8318457-5	1993	Under conditions of low p75 expression, Lys-20 IL-2 could act as an antagonist of wild-type IL-2 action.	Lysine	40-43	interleukin 2 receptor subunit beta	Homo sapiens	24-27
12029097-7	2002	In conclusion, it was shown that in SVG-bound CRFR1, Lys(257) of CRFR1 lies in close proximity (11.4 A) to Lys(16) of SVG.	Lysine	53-56	corticotropin releasing hormone receptor 1	Homo sapiens	46-51
12029097-7	2002	In conclusion, it was shown that in SVG-bound CRFR1, Lys(257) of CRFR1 lies in close proximity (11.4 A) to Lys(16) of SVG.	Lysine	53-56	corticotropin releasing hormone receptor 1	Homo sapiens	65-70
20617151-8	2010	In this study, we demonstrated that E. coli/Mycobacterial expression vectors bearing a weak promoter and lysine complementing gene in a recombinant lysine auxotroph of BCG could prevent genetic rearrangements and disruption of HIV 1gp120 gene expression, a key issue for engineering Mycobacterial based vaccine vectors.	Lysine	105-111	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	232-237
12029097-7	2002	In conclusion, it was shown that in SVG-bound CRFR1, Lys(257) of CRFR1 lies in close proximity (11.4 A) to Lys(16) of SVG.	Lysine	107-110	corticotropin releasing hormone receptor 1	Homo sapiens	46-51
12029097-7	2002	In conclusion, it was shown that in SVG-bound CRFR1, Lys(257) of CRFR1 lies in close proximity (11.4 A) to Lys(16) of SVG.	Lysine	107-110	corticotropin releasing hormone receptor 1	Homo sapiens	65-70
8476297-2	1993	However, the removal of the (Glu-Ala)2 peptide from the MF alpha 1 spacer region (Lys-Arg-Glu-Ala-Glu-Ala) yielded decreased levels of extracellular alpha-amylase.	Lysine	82-85	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	56-66
8454654-6	1993	Preceding the phosphorylation site, synaptotagmins I and II contain a lysine-rich sequence.	Lysine	70-76	synaptotagmin 1	Homo sapiens	36-59
8454654-8	1993	In recombinant proteins, removal of the lysine-rich sequence of synaptotagmin I makes its phosphorylation dependent on exogenous polylysine, suggesting that the lysine-rich sequence in synaptotagmin serves as an endogenous polylysine stimulation signal for casein kinase II.	Lysine	40-46	synaptotagmin 1	Homo sapiens	64-79
20617151-8	2010	In this study, we demonstrated that E. coli/Mycobacterial expression vectors bearing a weak promoter and lysine complementing gene in a recombinant lysine auxotroph of BCG could prevent genetic rearrangements and disruption of HIV 1gp120 gene expression, a key issue for engineering Mycobacterial based vaccine vectors.	Lysine	148-154	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	232-237
8454654-8	1993	In recombinant proteins, removal of the lysine-rich sequence of synaptotagmin I makes its phosphorylation dependent on exogenous polylysine, suggesting that the lysine-rich sequence in synaptotagmin serves as an endogenous polylysine stimulation signal for casein kinase II.	Lysine	133-139	synaptotagmin 1	Homo sapiens	64-79
19949111-3	2010	In this study, we show that BCR cross-linking induces histone lysine acetylation at the Btk promoter, correlating with marked recruitment of histone acetyltransferase E1A-associated 300-kDa protein (p300) to the locus.	Lysine	62-68	E1A binding protein p300	Homo sapiens	141-203
12093795-3	2002	The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176).	Lysine	66-69	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
19949111-6	2010	Interestingly, we found that BCR signaling induces Btk lysine acetylation mediated by p300.	Lysine	55-61	E1A binding protein p300	Homo sapiens	86-90
8383676-3	1993	The bacterially expressed and purified Cdc34 protein is shown here to catalyze its own ubiquitination via an intramolecular transfer of its thiol ester-linked ubiquitin to a lysine.	Lysine	174-180	ubiquitin	Saccharomyces cerevisiae S288C	87-96
12105226-7	2002	Mutational analysis of Rab15 indicates that lysine at position 48 (K48Q) is important for the binding of Rab15-GDP to Mss4.	Lysine	44-50	RAB15, member RAS oncogene family	Homo sapiens	23-28
20010813-0	2010	Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.	Lysine	55-58	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	32-36
12105226-7	2002	Mutational analysis of Rab15 indicates that lysine at position 48 (K48Q) is important for the binding of Rab15-GDP to Mss4.	Lysine	44-50	RAB15, member RAS oncogene family	Homo sapiens	105-110
8490130-4	1993	The encoded protein most resembles the endoplasmic reticulum (ER) resident HSP90 protein, the 94 kDa glucose-regulated protein (GRP94) of vertebrates, as it possesses both the characteristic N-terminal domain including a signal peptide sequence and the C-terminal ER retention signal (Lys-Asp-Glu-Leu).	Lysine	285-288	HSP90	Hordeum vulgare	75-80
20010813-6	2010	We uncovered a new pathway, which facilitates ubiquitylation at Lys 107 of proliferating cell nuclear antigen (PCNA).	Lysine	64-67	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	75-109
12027806-5	2002	Site-specific mutagenesis pinpointed the need for glycine and serine residues in the cleavage sequence Leu-Ser-Lys-Gly-Ser-Ile-Val-Val, which is localized between the two epidermal-growth-factor-like motifs of the mucin.	Lysine	111-114	LOC100508689	Homo sapiens	214-219
20010813-6	2010	We uncovered a new pathway, which facilitates ubiquitylation at Lys 107 of proliferating cell nuclear antigen (PCNA).	Lysine	64-67	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	111-115
20023648-6	2010	Mechanistically, we provide evidence that HERC2 facilitates assembly of the ubiquitin-conjugating enzyme Ubc13 with RNF8, thereby promoting DNA damage-induced formation of Lys 63-linked ubiquitin chains.	Lysine	172-175	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Homo sapiens	42-47
8437979-4	1993	Conversion of Glu-PLG to the preactivated form Lys-PLG, in the vicinity of the cell surface, may also precede plasmin formation.	Lysine	47-50	plasminogen	Homo sapiens	18-21
8437979-4	1993	Conversion of Glu-PLG to the preactivated form Lys-PLG, in the vicinity of the cell surface, may also precede plasmin formation.	Lysine	47-50	plasminogen	Homo sapiens	51-54
19861417-7	2009	Persistent DHCR24 overexpression did not alter the phosphorylation status of p53 but resulted in decreased acetylation of p53 at lysine residues 373 and 382 in the nucleus after treatment with hydrogen peroxide.	Lysine	129-135	24-dehydrocholesterol reductase	Homo sapiens	11-17
8437979-4	1993	Conversion of Glu-PLG to the preactivated form Lys-PLG, in the vicinity of the cell surface, may also precede plasmin formation.	Lysine	47-50	plasminogen	Homo sapiens	110-117
8381673-7	1993	Both virus-bound and solubilized neuraminidase are selectively modified by PLP at the lysine-553.	Lysine	86-92	neuraminidase 1	Homo sapiens	33-46
12208845-0	2002	Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.	Lysine	43-46	lysine methyltransferase 5A	Homo sapiens	68-75
12208845-4	2002	Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation were inversely correlated to transient H4 Lys 16 acetylation in early S-phase.	Lysine	77-80	lysine methyltransferase 5A	Homo sapiens	16-23
12208845-4	2002	Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation were inversely correlated to transient H4 Lys 16 acetylation in early S-phase.	Lysine	138-141	lysine methyltransferase 5A	Homo sapiens	16-23
12208845-5	2002	These data suggest that H4 Lys 20 methylation by PR-Set7 during mitosis acts to antagonize H4 Lys 16 acetylation and to establish a mechanism by which this mark is epigenetically transmitted.	Lysine	27-30	lysine methyltransferase 5A	Homo sapiens	49-56
12208845-5	2002	These data suggest that H4 Lys 20 methylation by PR-Set7 during mitosis acts to antagonize H4 Lys 16 acetylation and to establish a mechanism by which this mark is epigenetically transmitted.	Lysine	94-97	lysine methyltransferase 5A	Homo sapiens	49-56
8381673-7	1993	Both virus-bound and solubilized neuraminidase are selectively modified by PLP at the lysine-553.	Lysine	86-92	pyridoxal phosphatase	Homo sapiens	75-78
20003410-4	2009	RESULTS: We report that H2A.Z-1 and H2A.Z-2 are expressed across a wide range of human tissues, they are both acetylated at lysine residues within the N-terminal region and they exhibit similar, but nonidentical, distributions within chromatin.	Lysine	124-130	H2A.Z variant histone 2	Homo sapiens	36-43
8420991-3	1993	Previously we have shown that the region around the biotinyl lysine of the 1.3 S subunit is critical for catalysis, that peptides in the amino-terminal region of 1.3 S are capable of forming complexes with 12 S and 5 S, and that amino acids in the carboxyl terminus of the 1.3 S subunit form part of the recognition site for holocarboxylase synthetase.	Lysine	61-67	holocarboxylase synthetase	Homo sapiens	325-351
12350019-11	2002	Pre-feeding insulin levels were increased (P &lt; 0.05) with increasing level of lysine.	Lysine	81-87	insulin	Sus scrofa	12-19
12163582-3	2002	In chicken cells, the nsP4 Arg183 mutants had a nonconditionally lethal, temperature-sensitive (ts) growth phenotype caused by a ts defect in minus-strand synthesis whose extent varied with the particular amino acid substituted (Ser&gt;Ala&gt;Lys).	Lysine	243-246	serine protease 57	Homo sapiens	22-26
20003410-5	2009	Our results suggest that H2A.Z-2 preferentially associates with H3 trimethylated at lysine 4 compared to H2A.Z-1.	Lysine	84-90	H2A.Z variant histone 2	Homo sapiens	25-32
19815559-6	2009	Subsequent peptide mapping using chemical and proteinase cleavages of purified wild-type and mutant GLP1 receptor identified that the Arg(131)-Lys(136) segment at the juxtamembrane region of the receptor amino terminus contained the site of labeling for the position 24 probe, and the specific receptor residue labeled by this probe was identified as Glu(133) by radiochemical sequencing.	Lysine	143-146	glucagon like peptide 1 receptor	Homo sapiens	100-113
12163583-2	2002	76:8632-8640, 2002) found minus-strand synthesis to be temperature sensitive in vertebrate and invertebrate cells when the Arg183 residue of the Sindbis virus nsP4 polymerase was changed to Ser, Ala, or Lys.	Lysine	203-206	serine protease 57	Homo sapiens	159-163
1448098-8	1992	The gene, named EGD1 (enhancer of GAL4 DNA binding), encodes a highly basic protein (21% lysine and arginine) with a predicted molecular mass of 16.5 kDa.	Lysine	89-95	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	34-38
19879767-0	2009	Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.	Lysine	45-48	opioid related nociceptin receptor 1	Homo sapiens	93-97
12221124-9	2002	Last, we show that disruption of the functional interaction between endogenous FIP200 with FAK leads to increased FAK phosphorylation and partial restoration of cell cycle progression in cells plated on poly-L-lysine, providing further support for FIP200 as a negative regulator of FAK.	Lysine	203-216	protein tyrosine kinase 2	Homo sapiens	91-94
19879767-1	2009	[Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin.	Lysine	9-12	opioid related nociceptin receptor 1	Homo sapiens	49-53
19879767-4	2009	The mutant receptor Gln205Ala was found to be as active as wild-type ORL1 for both nociceptin and [Arg(14),Lys(15)]nociceptin.	Lysine	107-110	opioid related nociceptin receptor 1	Homo sapiens	69-73
12060650-5	2002	We found that GFP-HP1gamma is preferentially associated with the transcriptionally "inactive" heterochromatin fraction, a fraction enriched in Lys-9-methylated histone H3.	Lysine	143-146	chromobox 3	Homo sapiens	18-26
1438209-6	1992	Lp(a) binding is inhibited by epsilon-aminocaproic acid, indicating lysine binding site specificity.	Lysine	68-74	lipoprotein(a)	Homo sapiens	0-5
19744555-9	2009	Taken together, we propose that Ubc9-mediated sumoylation at lysine 25 of FOXL2 is required for transcriptional repression of the StAR gene and may be responsible for controlling the development of ovarian follicles.	Lysine	61-67	ubiquitin conjugating enzyme E2 I	Homo sapiens	32-36
1526970-3	1992	In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine.	Lysine	260-266	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	97-101
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	67-70	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	44-49
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	44-49
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	44-49
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Lysine	118-121	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	44-49
19744555-9	2009	Taken together, we propose that Ubc9-mediated sumoylation at lysine 25 of FOXL2 is required for transcriptional repression of the StAR gene and may be responsible for controlling the development of ovarian follicles.	Lysine	61-67	steroidogenic acute regulatory protein	Homo sapiens	130-134
1380438-9	1992	Highly purified alpha 1I3 was phosphorylated by muscle- or liver-derived insulin receptors in the presence of 1 microM poly-L-lysine and comigrated with pp195 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Lysine	119-132	alpha-1-inhibitor III	Rattus norvegicus	16-25
12176364-0	2002	A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.	Lysine	24-27	GRB2 related adaptor protein 2	Homo sapiens	94-98
19692349-7	2009	Furthermore, myotubes formed in culture from human laminin-alpha2-deficient patient myoblasts produced high levels of activated caspase-3 when grown on poly-L-lysine, but not when grown on a laminin-alpha2-containing substrate or when treated with BIPs.	Lysine	152-165	laminin subunit alpha 2	Homo sapiens	51-65
11988069-5	2002	Glutamic acid substitutions for two lysine residues in the activation loop of FAK, based upon the K650E (Lys(650--&gt;)Glu) mutant of fibroblast-growth-factor receptor 3, were made to create "SuperFAK".	Lysine	36-42	protein tyrosine kinase 2	Homo sapiens	78-81
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Lysine	169-172	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
1644824-1	1992	Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells.	Lysine	176-179	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
11988069-5	2002	Glutamic acid substitutions for two lysine residues in the activation loop of FAK, based upon the K650E (Lys(650--&gt;)Glu) mutant of fibroblast-growth-factor receptor 3, were made to create "SuperFAK".	Lysine	105-108	protein tyrosine kinase 2	Homo sapiens	78-81
19822661-3	2009	Specifically, deleting as few as 20 amino acids, or substituting glutamines for lysines in the tail, greatly impaired K36 methylation by Set2.	Lysine	80-87	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	137-141
12058023-6	2002	A mutation in the lysine repeat in the hypervariable region of Rsr1/Bud1 specifically abolished its plasma membrane localization, whereas a mutation at the CAAX motif eliminated both plasma membrane and internal membrane association of Rsr1/Bud1.	Lysine	18-24	Ras family GTPase RSR1	Saccharomyces cerevisiae S288C	63-67
12058023-6	2002	A mutation in the lysine repeat in the hypervariable region of Rsr1/Bud1 specifically abolished its plasma membrane localization, whereas a mutation at the CAAX motif eliminated both plasma membrane and internal membrane association of Rsr1/Bud1.	Lysine	18-24	Ras family GTPase RSR1	Saccharomyces cerevisiae S288C	68-72
1353732-2	1992	When phosphorylated cystatin alpha (P-cystatin alpha) was incubated with epidermal transglutaminase (TGase) and Ca2+ ions, polymerized protein was produced by formation of epsilon-(gamma-glutamyl)lysine cross-linking peptide bonds between lysine residues of cystatin alpha and glutamine residues of suitable protein(s) in the enzyme preparation.	Lysine	196-202	cystatin A	Homo sapiens	20-34
1353732-2	1992	When phosphorylated cystatin alpha (P-cystatin alpha) was incubated with epidermal transglutaminase (TGase) and Ca2+ ions, polymerized protein was produced by formation of epsilon-(gamma-glutamyl)lysine cross-linking peptide bonds between lysine residues of cystatin alpha and glutamine residues of suitable protein(s) in the enzyme preparation.	Lysine	196-202	cystatin A	Homo sapiens	38-52
1353732-2	1992	When phosphorylated cystatin alpha (P-cystatin alpha) was incubated with epidermal transglutaminase (TGase) and Ca2+ ions, polymerized protein was produced by formation of epsilon-(gamma-glutamyl)lysine cross-linking peptide bonds between lysine residues of cystatin alpha and glutamine residues of suitable protein(s) in the enzyme preparation.	Lysine	196-202	transglutaminase 1	Homo sapiens	101-106
19956600-5	2009	The NTD RSK2 possesses a three-stranded betaB-sheet inserted in the N-terminal lobe, resulting in displacement of the alphaC-helix and disruption of the Lys-Glu interaction, classifying the kinase conformation as inactive.	Lysine	153-156	ribosomal protein S6 kinase A3	Homo sapiens	8-12
1353732-2	1992	When phosphorylated cystatin alpha (P-cystatin alpha) was incubated with epidermal transglutaminase (TGase) and Ca2+ ions, polymerized protein was produced by formation of epsilon-(gamma-glutamyl)lysine cross-linking peptide bonds between lysine residues of cystatin alpha and glutamine residues of suitable protein(s) in the enzyme preparation.	Lysine	196-202	cystatin A	Homo sapiens	38-52
12058023-7	2002	Thus the lysine repeat and the CAAX motif of Rsr1/Bud1 are important for its localization to the plasma membrane and to the polarized growth sites.	Lysine	9-15	Ras family GTPase RSR1	Saccharomyces cerevisiae S288C	50-54
19956600-8	2009	Mutation of this lysine to alanine impaired both NTDs in vitro and full length RSK2 ex vivo activity, emphasizing the importance of this interaction.	Lysine	17-23	ribosomal protein S6 kinase A3	Homo sapiens	79-83
19801601-8	2009	Moreover, in vitro assays demonstrated that histone acetyltransferase p300 can catalyze H3 Lys(23) propionylation, whereas histone deacetylase Sir2 can remove this modification in the presence of NAD(+).	Lysine	91-94	E1A binding protein p300	Homo sapiens	70-74
12127488-1	2002	Lysine biosynthesis in yeast requires the posttranslational conversion of the alpha-aminoadipate semialdehyde reductase Lys2 by the 4"-phosphopantetheinyl transferase (PPTase) Lys5 from the inactive apo-form into the catalytically active holo-form.	Lysine	0-6	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	120-124
12127488-1	2002	Lysine biosynthesis in yeast requires the posttranslational conversion of the alpha-aminoadipate semialdehyde reductase Lys2 by the 4"-phosphopantetheinyl transferase (PPTase) Lys5 from the inactive apo-form into the catalytically active holo-form.	Lysine	0-6	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	176-180
1420981-6	1992	We have synthesized an anionic melittin analogue of MLT (E-MLT; net charge -4) in which all five lysine and arginine residues are replaced with glutamate, and acetyl and succinyl derivatives of E-MLT (net charges -5 and -6).	Lysine	97-103	MALT1 paracaspase	Homo sapiens	57-62
1515027-3	1992	The masu salmon sGnRH precursor was composed of a signal peptide, sGnRH and a GnRH-associated peptide (GAP) which was connected to sGnRH by a Gly-Lys-Arg sequence.	Lysine	146-149	gonadotropin releasing hormone 1	Homo sapiens	17-21
19731963-6	2009	Especially, several lysine residues on the SAGA subunits Spt7p and Sgf73p were found to be acetylated.	Lysine	20-26	SAGA histone acetyltransferase complex subunit SPT7	Saccharomyces cerevisiae S288C	57-62
12185510-0	2002	Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.	Lysine	84-87	hemoglobin subunit epsilon 1	Homo sapiens	64-68
12185510-1	2002	Hemoglobin (Hb) Korle-Bu (beta73; Asp-Asn) is the most frequent of the rare beta-chain variants in the population of West Africa whereas Hb E (beta26; Glu-Lys) is common among the Southeast Asian population.	Lysine	155-158	hemoglobin subunit epsilon 1	Homo sapiens	137-141
19771477-3	2009	Squirrel RNase 1 genes encode typical RNase A ribonucleases, each with eight cysteines, a conserved CKXXNTF signature motif, and a canonical His(12)-Lys(41)-His(119) catalytic triad.	Lysine	149-152	ribonuclease A family member 1, pancreatic	Homo sapiens	9-16
12072377-1	2002	Aortic carboxypeptidase-like protein (ACLP) is a 175-kDa protein that is expressed in vascular smooth muscle cells and contains a signal peptide sequence, a lysine- and proline-rich repeating motif, a discoidin-like domain with 35% identity to discoidin I, and a carboxypeptidase-like domain that is 39% identical with carboxypeptidase E.	Lysine	157-163	AE binding protein 1	Mus musculus	0-36
12072377-1	2002	Aortic carboxypeptidase-like protein (ACLP) is a 175-kDa protein that is expressed in vascular smooth muscle cells and contains a signal peptide sequence, a lysine- and proline-rich repeating motif, a discoidin-like domain with 35% identity to discoidin I, and a carboxypeptidase-like domain that is 39% identical with carboxypeptidase E.	Lysine	157-163	AE binding protein 1	Mus musculus	38-42
18965468-1	1992	Adsorbed amounts of poly-l-lysine (pLys) and bromide ion on hydroxyapatite (HAp) from aqueous solutions of poly-l-lysine hydrobromide, and amounts of calcium and phosphate ions liberated concurrently from HAp during the adsorption of pLys were determined at 25 degrees .	Lysine	20-33	reticulon 3	Homo sapiens	76-79
19773423-9	2009	Moreover, we also observed that PCAF acetylates cdk2 at lysine 33.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	32-36
1535355-6	1992	epsilon-Aminocaproic acid, which competes for lysine residues that are critical to the binding of plasminogen or plasmin to substrates, inhibited the digestion of high molecular weight kininogen by plasmin, which is consistent with the evidence that the 438-439 Lys-His was a primary site of plasmin attack on high molecular weight kininogen.	Lysine	46-52	plasminogen	Homo sapiens	98-105
1535355-6	1992	epsilon-Aminocaproic acid, which competes for lysine residues that are critical to the binding of plasminogen or plasmin to substrates, inhibited the digestion of high molecular weight kininogen by plasmin, which is consistent with the evidence that the 438-439 Lys-His was a primary site of plasmin attack on high molecular weight kininogen.	Lysine	46-52	plasminogen	Homo sapiens	113-120
11956210-2	2002	We and others have recently shown that Tat is directly acetylated at lysine 28, within the activation domain, and lysine 50, in the TAR RNA binding domain, by Tat-associated histone acetyltransferases p300, p300/CBP-associating factor, and hGCN5.	Lysine	69-75	E1A binding protein p300	Homo sapiens	201-205
11956210-2	2002	We and others have recently shown that Tat is directly acetylated at lysine 28, within the activation domain, and lysine 50, in the TAR RNA binding domain, by Tat-associated histone acetyltransferases p300, p300/CBP-associating factor, and hGCN5.	Lysine	69-75	E1A binding protein p300	Homo sapiens	207-211
11956210-2	2002	We and others have recently shown that Tat is directly acetylated at lysine 28, within the activation domain, and lysine 50, in the TAR RNA binding domain, by Tat-associated histone acetyltransferases p300, p300/CBP-associating factor, and hGCN5.	Lysine	114-120	E1A binding protein p300	Homo sapiens	201-205
11956210-2	2002	We and others have recently shown that Tat is directly acetylated at lysine 28, within the activation domain, and lysine 50, in the TAR RNA binding domain, by Tat-associated histone acetyltransferases p300, p300/CBP-associating factor, and hGCN5.	Lysine	114-120	E1A binding protein p300	Homo sapiens	207-211
1535355-6	1992	epsilon-Aminocaproic acid, which competes for lysine residues that are critical to the binding of plasminogen or plasmin to substrates, inhibited the digestion of high molecular weight kininogen by plasmin, which is consistent with the evidence that the 438-439 Lys-His was a primary site of plasmin attack on high molecular weight kininogen.	Lysine	46-52	plasminogen	Homo sapiens	113-120
1571548-9	1992	A conservative substitution of the P4 arginine by lysine resulted in a decrease in vWF processing by PACE, as did a nonconservative substitution to alanine.	Lysine	50-56	furin, paired basic amino acid cleaving enzyme	Homo sapiens	101-105
19773423-9	2009	Moreover, we also observed that PCAF acetylates cdk2 at lysine 33.	Lysine	56-62	cyclin dependent kinase 2	Homo sapiens	48-52
1571548-11	1992	These data indicate that both the P4 arginine and the P2 lysine play an important role in substrate recognition by PACE.	Lysine	57-63	furin, paired basic amino acid cleaving enzyme	Homo sapiens	115-119
19773423-10	2009	As this lysine is essential for the interaction with ATP, acetylation of this residue inhibits cdk2 activity.	Lysine	8-14	cyclin dependent kinase 2	Homo sapiens	95-99
19755537-6	2009	clf-59 mutants have elevated levels of trimethylation on lysine 27 of histone H3 (H3K27me3) at FLC.	Lysine	57-63	SET domain-containing protein	Arabidopsis thaliana	0-3
1312281-5	1992	Since previous work indicated that the lysine residue at position 461 is important for the neuraminidase activity of HN, we used site-directed mutation to produce HN protein with this lysine residue changed to glutamic acid.	Lysine	39-45	neuraminidase 1	Homo sapiens	91-104
1312281-5	1992	Since previous work indicated that the lysine residue at position 461 is important for the neuraminidase activity of HN, we used site-directed mutation to produce HN protein with this lysine residue changed to glutamic acid.	Lysine	184-190	neuraminidase 1	Homo sapiens	91-104
12021356-12	2002	These residues most likely form ionic interactions with conserved acidic amino acids on E7 since a stable pRB/E7 interaction was restored when the lysine residues on pRB and the acidic residues on E7 were interchanged.	Lysine	147-153	RB transcriptional corepressor 1	Homo sapiens	106-109
12021356-12	2002	These residues most likely form ionic interactions with conserved acidic amino acids on E7 since a stable pRB/E7 interaction was restored when the lysine residues on pRB and the acidic residues on E7 were interchanged.	Lysine	147-153	RB transcriptional corepressor 1	Homo sapiens	166-169
19810014-1	2009	Peptides modified by pyridoxal-5"-phosphate (PLP), linked to a lysine residue via reductive amination, exhibit distinct spectral characteristics in the collision-induced dissociation (CID) tandem mass (MS/MS) spectra that are described here.	Lysine	63-69	pyridoxal phosphatase	Homo sapiens	45-48
12022882-5	2002	Lys(147) and Arg(154) mutants were inhibited by TFPI approximately 2-fold slower than wild type; however, both Arg(143) and Arg(150) mutants were inhibited normally by the inhibitor.	Lysine	0-3	tissue factor pathway inhibitor	Homo sapiens	48-52
1531656-6	1992	Acylation of the 5 lysine residues of fragment 1 by the action of acetic anhydride (500-fold molar excess) in the presence of 75 mM Ca(II), pH 8.0, results in loss of positive cooperativity in Ca(II) binding (Scatchard plot) and an increase in the number of Ca(II) ions bound.	Lysine	19-25	carbonic anhydrase 2	Bos taurus	132-138
1531656-6	1992	Acylation of the 5 lysine residues of fragment 1 by the action of acetic anhydride (500-fold molar excess) in the presence of 75 mM Ca(II), pH 8.0, results in loss of positive cooperativity in Ca(II) binding (Scatchard plot) and an increase in the number of Ca(II) ions bound.	Lysine	19-25	carbonic anhydrase 2	Bos taurus	193-199
1531656-6	1992	Acylation of the 5 lysine residues of fragment 1 by the action of acetic anhydride (500-fold molar excess) in the presence of 75 mM Ca(II), pH 8.0, results in loss of positive cooperativity in Ca(II) binding (Scatchard plot) and an increase in the number of Ca(II) ions bound.	Lysine	19-25	carbonic anhydrase 2	Bos taurus	193-199
19706603-1	2009	In replicating yeast, lysine 63-linked polyubiquitin (polyUb) chains are extended from the ubiquitin moiety of monoubiquitinated proliferating cell nuclear antigen (monoUb-PCNA) by the E2-E3 complex of (Ubc13-Mms2)-Rad5.	Lysine	22-28	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	129-163
1318546-9	1992	Our analysis suggests that apo[a] kringle-type 10 has a high probability of binding to lysine in the same way as PGK4.	Lysine	87-93	lipoprotein(a)	Homo sapiens	27-32
12004135-4	2002	Moreover, the complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1gamma, and Polycomb group (PcG) proteins.	Lysine	107-113	chromobox 3	Homo sapiens	131-139
1531022-4	1992	Plasmin in a complex with streptokinase or bound to epsilon-aminocaproic acid is protected from inhibition by thrombospondin, thereby implicating the lysine-binding kringle domains of plasmin in the inhibition process.	Lysine	150-156	plasminogen	Homo sapiens	0-7
19706603-1	2009	In replicating yeast, lysine 63-linked polyubiquitin (polyUb) chains are extended from the ubiquitin moiety of monoubiquitinated proliferating cell nuclear antigen (monoUb-PCNA) by the E2-E3 complex of (Ubc13-Mms2)-Rad5.	Lysine	22-28	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	203-208
1531022-4	1992	Plasmin in a complex with streptokinase or bound to epsilon-aminocaproic acid is protected from inhibition by thrombospondin, thereby implicating the lysine-binding kringle domains of plasmin in the inhibition process.	Lysine	150-156	plasminogen	Homo sapiens	184-191
11867624-2	2002	We report that proteinases released from either mononucleated blood cells or polymorphonuclear neutrophils degranulated by inflammatory stimuli generate an SDF-1 fragment that is deleted from amino-terminal residues Lys(1)-Pro(2)-Val(3), as characterized by mass spectrometry analysis.	Lysine	216-219	C-X-C motif chemokine ligand 12	Homo sapiens	156-161
19706603-1	2009	In replicating yeast, lysine 63-linked polyubiquitin (polyUb) chains are extended from the ubiquitin moiety of monoubiquitinated proliferating cell nuclear antigen (monoUb-PCNA) by the E2-E3 complex of (Ubc13-Mms2)-Rad5.	Lysine	22-28	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	209-213
19706603-1	2009	In replicating yeast, lysine 63-linked polyubiquitin (polyUb) chains are extended from the ubiquitin moiety of monoubiquitinated proliferating cell nuclear antigen (monoUb-PCNA) by the E2-E3 complex of (Ubc13-Mms2)-Rad5.	Lysine	22-28	DNA helicase RAD5	Saccharomyces cerevisiae S288C	215-219
19706603-3	2009	The unusual ability of Ubc13-Mms2 to synthesize unanchored Lys(63)-linked polyUb chains in vitro allowed us to resolve the individual roles that it and Rad5 play in the catalysis and specificity of PCNA polyubiquitination.	Lysine	59-62	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	23-28
11925461-0	2002	Differential regulation of porcine hepatic IGF-I mRNA expression and plasma IGF-I concentration by a low lysine diet.	Lysine	105-111	insulin like growth factor 1	Sus scrofa	43-48
11925461-0	2002	Differential regulation of porcine hepatic IGF-I mRNA expression and plasma IGF-I concentration by a low lysine diet.	Lysine	105-111	insulin like growth factor 1	Sus scrofa	76-81
11925461-1	2002	The influence of dietary lysine on hepatic insulin-like growth factor-I (IGF-I) gene expression and plasma IGF-I level was investigated.	Lysine	25-31	insulin like growth factor 1	Sus scrofa	43-71
1665793-0	1991	The 5-HT3 receptor antagonists LY 277359 and granisetron potentiate the suppressant action of apomorphine on the basal firing rate of ventral tegmental dopamine cells.	Lysine	31-33	5-hydroxytryptamine receptor 3A	Rattus norvegicus	4-18
19706603-3	2009	The unusual ability of Ubc13-Mms2 to synthesize unanchored Lys(63)-linked polyUb chains in vitro allowed us to resolve the individual roles that it and Rad5 play in the catalysis and specificity of PCNA polyubiquitination.	Lysine	59-62	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	29-33
19706603-6	2009	Thus, Rad5 acts both to align monoUb-PCNA with Ub-charged Ubc13 and to stimulate Ub transfer onto Lys(63) of a Ub acceptor.	Lysine	98-101	DNA helicase RAD5	Saccharomyces cerevisiae S288C	6-10
1930159-0	1991	The processing of Alzheimer A4/beta-amyloid protein precursor: identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide.	Lysine	127-130	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	28-35
1930159-0	1991	The processing of Alzheimer A4/beta-amyloid protein precursor: identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide.	Lysine	127-130	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	34-35
19710011-8	2009	Mass spectrometric analysis showed that p300 acetylates four lysine residues in the C-terminal domain of TP2.	Lysine	61-67	E1A binding protein p300	Homo sapiens	40-44
1930159-0	1991	The processing of Alzheimer A4/beta-amyloid protein precursor: identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide.	Lysine	127-130	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	36-37
1930159-2	1991	A metalloendopeptidase was identified in the soluble fraction of post mortem human cerebral cortex which cleaves the substrate at the Lys-Leu bond.	Lysine	134-137	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	0-1
11925461-10	2002	We conclude that the reduction in plasma IGF-I caused by reduced dietary lysine may have been due in part to suppression of post-transcriptional events in IGF-I expression.	Lysine	73-79	insulin like growth factor 1	Sus scrofa	41-46
11925461-10	2002	We conclude that the reduction in plasma IGF-I caused by reduced dietary lysine may have been due in part to suppression of post-transcriptional events in IGF-I expression.	Lysine	73-79	insulin like growth factor 1	Sus scrofa	155-160
19635459-2	2009	It was found recently that Ubc9, the SUMO E2 conjugating enzyme, is covalently modified by SUMO at a lysine 14 in the N-terminal alpha helix, and that SUMO-modified Ubc9 has enhanced conjugation activity for certain target proteins containing a SUMO-interacting motif (SIM).	Lysine	101-107	ubiquitin conjugating enzyme E2 I	Homo sapiens	27-31
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Lysine	138-141	cyclin D1	Homo sapiens	22-31
1898413-5	1991	The Glu to Lys substitution is proven to account for the abnormal physical properties of the patients lysosomal alpha-glucosidase precursor and to prevent the formation of catalytically active enzyme.	Lysine	11-14	alpha glucosidase	Homo sapiens	102-129
1832675-4	1991	Accelerated plasmin generation did not occur in the presence of epsilon-amino caproic acid or if actin was exposed to acetic anhydride, an agent known to acetylate lysine residues.	Lysine	164-170	plasminogen	Homo sapiens	12-19
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Lysine	138-141	RB transcriptional corepressor like 1	Homo sapiens	120-124
19635459-2	2009	It was found recently that Ubc9, the SUMO E2 conjugating enzyme, is covalently modified by SUMO at a lysine 14 in the N-terminal alpha helix, and that SUMO-modified Ubc9 has enhanced conjugation activity for certain target proteins containing a SUMO-interacting motif (SIM).	Lysine	101-107	ubiquitin conjugating enzyme E2 I	Homo sapiens	165-169
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Lysine	138-141	RB transcriptional corepressor like 1	Homo sapiens	120-124
19557426-7	2009	Interestingly, DIDO3 is missing from the synaptonemal complex in Atm mutant spermatocytes, which form synapses but show persistent trimethylation of histone H3 lysine 4.	Lysine	160-166	ataxia telangiectasia mutated	Mus musculus	65-68
11983172-3	2002	In vitro assays show an indispensable role for H3 and H4 tails, especially major lysine substrates, in p300-dependent transcriptional activation, as well as activator-targeted acetylation of promoter-proximal histone tails by p300.	Lysine	81-87	E1A binding protein p300	Homo sapiens	103-107
11773068-4	2002	In hBVR, a lysine replaces L(3).	Lysine	11-17	biliverdin reductase A	Homo sapiens	3-7
1910040-0	1991	Replacement of lysine 234 affects transition state stabilization in the active site of beta-lactamase TEM1.	Lysine	15-21	hypothetical protein	Escherichia coli	102-106
1910040-8	1991	Therefore, lysine 234 in the E. coli beta-lactamase TEM-1 is involved both in the initial recognition of the substrate and in transition state stabilization.	Lysine	11-17	hypothetical protein	Escherichia coli	52-57
19706680-3	2009	Lysine 556 (K556) was found to be the major sumoylation site for Prox1 in vitro and in vivo.	Lysine	0-6	prospero homeobox 1	Homo sapiens	65-70
1840295-10	1991	In neuraminidase-treated type I, catalytic activity was also enhanced but lysine affinity remained unchanged.	Lysine	74-80	neuraminidase 1	Homo sapiens	3-16
11777905-4	2002	In comparison to HDAC1, HDAC3 preferentially deacetylated lysines 5 and 12 of H4 and lysine 5 of H2A.	Lysine	58-65	histone deacetylase 3	Homo sapiens	24-29
11777905-4	2002	In comparison to HDAC1, HDAC3 preferentially deacetylated lysines 5 and 12 of H4 and lysine 5 of H2A.	Lysine	58-64	histone deacetylase 3	Homo sapiens	24-29
19706680-4	2009	Mutation of this site (from lysine to arginine K556R) reduced DNA binding and the transcriptional activity of Prox1.	Lysine	28-34	prospero homeobox 1	Homo sapiens	110-115
19700617-0	2009	CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.	Lysine	39-45	Polycomb	Drosophila melanogaster	72-80
11836629-6	2002	Aldosterone response of ZG cells to 10(-7) M PACAP38 was unaffected by the PAC1-antagonist (A) PACAP(6-38), and significantly decreased by the VPAC1-A [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP(3-7) GRF(8-27)-NH(2).	Lysine	171-174	adenylate cyclase activating polypeptide 1	Rattus norvegicus	45-50
11931765-0	2002	Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.	Lysine	20-26	lysine acetyltransferase 2B	Homo sapiens	63-67
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	E1A binding protein p300	Homo sapiens	124-128
1856262-1	1991	GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.	Lysine	52-55	growth hormone secretagogue receptor	Homo sapiens	0-20
1856262-1	1991	GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.	Lysine	52-55	growth hormone secretagogue receptor	Homo sapiens	22-26
1856866-3	1991	For this insulin molecule, the first without detectable activity to be characterized, the A and B-chains are linked by a peptide bond between A1 Gly and B29 Lys.	Lysine	157-160	insulin	Sus scrofa	9-16
19700617-1	2009	Trimethylation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas acetylation of H3K27 (H3K27ac) has recently been shown to be associated with many active mammalian genes.	Lysine	29-35	Polycomb	Drosophila melanogaster	53-61
19700617-1	2009	Trimethylation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas acetylation of H3K27 (H3K27ac) has recently been shown to be associated with many active mammalian genes.	Lysine	29-35	Polycomb	Drosophila melanogaster	136-144
19449376-6	2009	Among heavy drinkers, the ADH1B Arg/Arg (55 years) and ALDH2 Glu/Lys genotypes (54 years) were found to confer a 15 and 16 years earlier carcinoma diagnosed age than His/His and Glu/Glu nondrinkers (both 70 years), respectively.	Lysine	65-68	aldehyde dehydrogenase 2 family member	Homo sapiens	55-60
1939027-4	1991	Comparing the 205-residue sequence of the skeletal myosin with those of cardiac, and gizzard myosins from chicken, considerable differences are recognized, especially in the amino-terminal region, but strong homologies are observed around the reactive lysine residue, around the epsilon-N-trimethyllysine residue, and around the consensus sequence of GXXGXGKT for nucleotide-binding proteins.	Lysine	252-258	myosin, heavy chain 15	Gallus gallus	51-57
1827591-10	1991	These results indicate that Lp(a) impairs the binding of plasminogen to fibrin and thereby decreases the generation of plasmin by occupying C-terminal lysine residues unveiled on the fibrin surface by plasmin degradation as recently reported (Circulation 1990;82[suppl III]:III-92).	Lysine	151-157	lipoprotein(a)	Homo sapiens	28-33
1827591-10	1991	These results indicate that Lp(a) impairs the binding of plasminogen to fibrin and thereby decreases the generation of plasmin by occupying C-terminal lysine residues unveiled on the fibrin surface by plasmin degradation as recently reported (Circulation 1990;82[suppl III]:III-92).	Lysine	151-157	plasminogen	Homo sapiens	119-126
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	160-186
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	188-192
11931765-3	2002	Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat.	Lysine	89-95	lysine acetyltransferase 2B	Homo sapiens	38-42
11931765-3	2002	Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat.	Lysine	183-189	lysine acetyltransferase 2B	Homo sapiens	38-42
11931765-4	2002	The three-dimensional solution structure of the PCAF bromodomain in complex with a lysine 50-acetylated Tat peptide together with biochemical analyses provides the structural basis for the specificity of this molecular recognition and reveals insights into the differences in ligand selectivity of bromodomains.	Lysine	83-89	lysine acetyltransferase 2B	Homo sapiens	48-52
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	mitogen-activated protein kinase 3	Mus musculus	133-174
11714719-9	2002	Lysine 115 is critically important for the membrane association of mGSTA4-4, most likely by entering into an electrostatic interaction with negatively charged phospholipid headgroups.	Lysine	0-6	glutathione S-transferase, alpha 4	Mus musculus	67-75
1848239-10	1991	Both CDC34 and E2(32k) exhibit a marked kinetic selectivity for processive multiubiquitination via Lys-48 of ubiquitin.	Lysine	99-102	ubiquitin-conjugating enzyme E2 R1	Oryctolagus cuniculus	5-10
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	ras homolog family member A	Mus musculus	240-244
19565568-10	2009	Compared to normal cells, silenced OPG gene in cancer cells were found to have reduced histone 3 lysine 4 tri-methylation (H3K4me3) and increased histone 3 lysine 27 tri-methylation (H3K27me3).	Lysine	97-103	TNF receptor superfamily member 11b	Homo sapiens	35-38
2006911-2	1991	Evidence is now presented that glucose is covalently attached to lysine-266 of purified human complement Factor B as a result of glycation.	Lysine	65-71	complement factor B	Homo sapiens	94-113
11929601-6	2002	The ubiquitin independence of Ste3p ligand-dependent uptake was further indicated by analysis of receptor mutants having Lys-to-Arg substitutions at all possible ubiquitin acceptor sites.	Lysine	121-124	ubiquitin	Saccharomyces cerevisiae S288C	4-13
19565568-10	2009	Compared to normal cells, silenced OPG gene in cancer cells were found to have reduced histone 3 lysine 4 tri-methylation (H3K4me3) and increased histone 3 lysine 27 tri-methylation (H3K27me3).	Lysine	156-162	TNF receptor superfamily member 11b	Homo sapiens	35-38
19570981-6	2009	Furthermore, a crystal structure of the E12V mutant hTCTP, which lacks the guanine nucleotide exchange factor activity, shows that the deficiency appears to be caused by loss of a salt-bridging interaction with Lys-45 of hRheb.	Lysine	211-214	Ras homolog, mTORC1 binding	Homo sapiens	221-226
11684677-10	2002	The increased antifibrinolytic potential of the Ile-325-containing TAFI variants reflects the fact that these variants have an increased ability to mediate the release of lysine from partially degraded fibrin and suppress plasminogen activation.	Lysine	171-177	carboxypeptidase B2	Homo sapiens	67-71
1998680-2	1991	Human Q31, murine, and human granzyme A hydrolyzed Arg- or Lys-containing thioesters very efficiently with kcat/KM of 10(4)-10(5) M-1 s-1.	Lysine	59-62	granzyme A	Homo sapiens	29-39
1827215-0	1991	Role of active center and lysine binding sites of plasmin in plasmin-induced platelet activation and disaggregation.	Lysine	26-32	plasminogen	Homo sapiens	50-57
1827215-0	1991	Role of active center and lysine binding sites of plasmin in plasmin-induced platelet activation and disaggregation.	Lysine	26-32	plasminogen	Homo sapiens	61-68
1827215-2	1991	In this study, the role of the active center and the lysine binding sites (LBS) of human plasmin in activating platelets and in dispersing platelet aggregates is investigated using aprotinin and the tripeptide Val-Phe-Lys-CH2Cl to inhibit the active center and using epsilon-aminocaproic acid (EACA) to specifically block the LBS.	Lysine	53-59	plasminogen	Homo sapiens	89-96
12785096-0	2002	Single-molecule measurement of elasticity of serine-, glutamate- and lysine-rich repeats of invertebrate connectin reveals that its elasticity is caused entropically by random coil structure.	Lysine	69-75	titin	Homo sapiens	105-114
12785096-3	2002	There are several extensible regions in I-connectin: two long PEVK regions, one unique sequence region and Ser-, Glu- and Lys-rich 68 residue-repeats called SEK repeats.	Lysine	122-125	titin	Homo sapiens	42-51
11736657-5	2001	Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively.	Lysine	88-96	ornithine decarboxylase 1	Homo sapiens	19-22
11736657-5	2001	Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively.	Lysine	88-96	ornithine decarboxylase 1	Homo sapiens	48-51
11736657-9	2001	Most notably, Lys(95) increased the K(m) for l-ornithine by 16-fold and for l-lysine by 3-fold, with 100-fold and 2.8-fold decreases in the k(cat) for ODC and lysine decarboxylase (LDC) activity respectively.	Lysine	14-17	ornithine decarboxylase 1	Homo sapiens	151-154
11598120-2	2001	In the insulin receptor"s kinase domain, Asp-1161 and Tyr-1162 in the peptide substrate-like sequence of the unphosphorylated activation loop can interact with four invariant residues in the active site: Lys-1085, Asp-1132, Arg-1136, and Gln-1208.	Lysine	204-207	insulin receptor	Homo sapiens	7-23
11739492-6	2001	These results strongly suggested that the positively charged lysine residues in the TCR-gamma chain CDR3 region encoded by the germline Jgamma1.2 gene play a key role in the recognition of diverse small molecular mass nonpeptide Ags.	Lysine	61-67	CDR3	Homo sapiens	100-104
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-36	ubiquitin	Saccharomyces cerevisiae S288C	52-61
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-36	ubiquitin	Saccharomyces cerevisiae S288C	77-86
11500494-6	2001	Furthermore, each of the two lysines harbors a poly-ubiquitin chain in which ubiquitin is linked to the lysine 63 of the preceding ubiquitin.	Lysine	29-36	ubiquitin	Saccharomyces cerevisiae S288C	77-86
11689449-0	2001	A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.	Lysine	11-17	E1A binding protein p300	Homo sapiens	98-102
11689053-6	2001	Unexpectedly, we also found that Tat could autoacetylate itself, which was specific to lysine residues 41 and 71.	Lysine	87-93	tyrosine aminotransferase	Homo sapiens	33-36
11481329-5	2001	Overexpression of tagged HDGF proteins with point mutations in the putative bipartite nuclear localization sequence in the carboxyl terminus demonstrated that single Lys --&gt; Asn mutations randomized HDGF expression to both the nucleus and cytoplasm similar to the empty vector.	Lysine	166-169	heparin binding growth factor	Homo sapiens	25-29
11481329-5	2001	Overexpression of tagged HDGF proteins with point mutations in the putative bipartite nuclear localization sequence in the carboxyl terminus demonstrated that single Lys --&gt; Asn mutations randomized HDGF expression to both the nucleus and cytoplasm similar to the empty vector.	Lysine	166-169	heparin binding growth factor	Homo sapiens	202-206
11481329-9	2001	We conclude that HDGF contains a true bipartite nuclear localization sequence with all three lysines necessary for nuclear targeting.	Lysine	93-100	heparin binding growth factor	Homo sapiens	17-21
11585801-4	2001	Lysine 149 of Xbra is conserved in all Brachyury homologues, while the corresponding amino acid in VegT and Eomesodermin is asparagine.	Lysine	0-6	T-box transcription factor Tr L homeolog	Xenopus laevis	14-18
11585801-5	2001	Mutation of this amino acid to lysine changes the inductive abilities of VegT and Eomesodermin to resemble that of Xbra.	Lysine	31-37	T-box transcription factor Tr L homeolog	Xenopus laevis	115-119
11567668-7	2001	A recently discovered thrombin-activatable fibrinolysis inhibitor (TAFI) eliminates carboxyterminal lysine residues from partially degraded fibrin and, thus, inhibits the second phase of fibrinolysis.	Lysine	100-106	carboxypeptidase B2	Homo sapiens	22-65
11567668-7	2001	A recently discovered thrombin-activatable fibrinolysis inhibitor (TAFI) eliminates carboxyterminal lysine residues from partially degraded fibrin and, thus, inhibits the second phase of fibrinolysis.	Lysine	100-106	carboxypeptidase B2	Homo sapiens	67-71
11445580-9	2001	Detailed analysis of the p300 selective inhibitor Lys-CoA showed that it exhibited slow, tight-binding kinetics.	Lysine	50-53	E1A binding protein p300	Homo sapiens	25-29
11514347-6	2001	Functional analysis of potential OPN interactions with conceptus and endometrial integrins was performed on LE and Tr cells in vitro using beads coated with OPN, poly-L-lysine, or recombinant OPN in which the Arg-Gly-Asp sequence was replaced with RGE or RAD.	Lysine	162-175	osteopontin	Ovis aries	33-36
11418614-4	2001	Conversely, mutation of the lysine 1136 inhibited the ability of the cells to increase cyclin E and cdk2 expression, to maintain long term phosphorylation of the ERK MAPK, and to enter S-phase but had no effect on the ability of the cells to phosphorylate the p38 MAPK or to migrate on type I collagen in response to EGF.	Lysine	28-34	cyclin dependent kinase 2	Homo sapiens	100-104
11485561-4	2001	Mutation of all 11 lysines in SSAT separately to arginine demonstrated that no single lysine residue is critical for its degradation in vitro, but mutant K87R had a significantly longer half-life, suggesting that lysine-87 may be the preferred site for ubiquitination.	Lysine	19-26	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	30-34
11485561-4	2001	Mutation of all 11 lysines in SSAT separately to arginine demonstrated that no single lysine residue is critical for its degradation in vitro, but mutant K87R had a significantly longer half-life, suggesting that lysine-87 may be the preferred site for ubiquitination.	Lysine	19-25	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	30-34
11481424-7	2001	Furthermore, p33ING2 expression increases the acetylation of p53 at Lys-382.	Lysine	68-71	inhibitor of growth family member 2	Homo sapiens	13-20
11463825-3	2001	For both DMR1 of Snrpn and the 5" untranslated region (5"-UTR) and 3"-UTR of U2af1-rs1, the methylated and nonexpressed maternal allele was underacetylated, relative to the paternal allele, at all H3 lysines tested (K14, K9, and K18).	Lysine	200-207	zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1	Mus musculus	77-86
11463825-4	2001	For H4, underacetylation of the maternal allele was exclusively (U2af1-rs1) or predominantly (Snrpn) at lysine 5.	Lysine	104-110	zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1	Mus musculus	65-74
11369780-2	2001	We showed previously that the products of the UBC13 and MMS2 genes function in error-free post-replicative DNA repair in the yeast Saccharomyces cerevisiae and form a complex that assembles Lys-63-linked polyubiquitin chains in vitro.	Lysine	190-193	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	46-51
11369780-2	2001	We showed previously that the products of the UBC13 and MMS2 genes function in error-free post-replicative DNA repair in the yeast Saccharomyces cerevisiae and form a complex that assembles Lys-63-linked polyubiquitin chains in vitro.	Lysine	190-193	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	56-60
11384967-4	2001	Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5.	Lysine	4-11	E1A binding protein p300	Homo sapiens	48-52
11384967-5	2001	The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat.	Lysine	29-36	E1A binding protein p300	Homo sapiens	40-44
11384967-6	2001	These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.	Lysine	58-65	tyrosine aminotransferase	Homo sapiens	95-98
11384967-6	2001	These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.	Lysine	58-65	E1A binding protein p300	Homo sapiens	193-197
11384967-6	2001	These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.	Lysine	58-65	tyrosine aminotransferase	Homo sapiens	225-228
12084985-4	2001	Microbeads coated with MK or poly-L-lysine induced clustering of glypican-2 as well as syndecan-3.	Lysine	29-42	glypican 2 (cerebroglycan)	Mus musculus	65-75
11486915-0	2001	Sustained oral lysine supplementation in ornithine delta-aminotransferase deficiency.	Lysine	15-21	ornithine aminotransferase	Homo sapiens	41-73
11373622-5	2001	A mutation of Lys 205 in eEF1Balpha that inserts into the Mg2+ binding site of eEF1A is lethal.	Lysine	14-17	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	79-84
11442827-7	2001	Results from competitive inhibition assays indicate that binding is mediated through the lysine binding sites in plasmin(ogen).	Lysine	89-95	plasminogen	Homo sapiens	113-120
11442827-8	2001	Carboxypeptidase B treatment and amino acid substitutions of the C-terminal lysyl residues of Eno indicated that the C-terminal lysine is pivotal for plasmin(ogen)-binding activity.	Lysine	128-134	plasminogen	Homo sapiens	150-157
11378154-3	2001	We observed that both AIDA (100 microM) and LY 367385 (30 microM), two blockers of mGluR1s, were able to fully prevent the induction of this form of synaptic plasticity, whereas MPEP (30 microM), a selective antagonist of the mGluR5 subtype, did not significantly affect the amplitude and time-course of corticostriatal LTD.	Lysine	44-46	glutamate receptor, ionotropic, kainate 1	Mus musculus	226-232
11441843-8	2001	The FCR of chicks fed feed-grade and extruded CSM plus 2% lysine at 21 d was significantly better than that of chicks fed feed-grade or extruded CSM alone.	Lysine	58-64	FCR	Gallus gallus	4-7
11371203-4	2001	Interactions between PLB molecules were measured following covalent modification of the single lysine (i.e., Lys(3)) in PLB isolated from cardiac SR membranes with fluorescein isothiocyanate (FITC) prior to co-reconstitution with the Ca-ATPase.	Lysine	95-101	phospholamban	Homo sapiens	21-24
11278381-4	2001	Our results identify lysine 82 as the major site of SUMO-1 modification in HSF2, which is located in a "wing" within the DNA-binding domain of this protein.	Lysine	21-27	small ubiquitin like modifier 1	Homo sapiens	52-58
11342641-2	2001	CPN cleaves the carboxyl-terminal amino acids arginine and lysine from biologically active peptides such as complement anaphylatoxins, kinins, and fibrinopeptides.	Lysine	59-65	carboxypeptidase N, polypeptide 1	Mus musculus	0-3
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	51-54	APC regulator of WNT signaling pathway	Homo sapiens	104-107
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	59-62	APC regulator of WNT signaling pathway	Homo sapiens	104-107
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	59-62	APC regulator of WNT signaling pathway	Homo sapiens	104-107
11331007-2	2001	Both catalytic sites are comprised of two histidine side chains acting as a general base-general acid pair and a phosphate-activating residue: an arginine in the case of PI-PLC and a lysine in RNase A.	Lysine	183-189	ribonuclease A family member 1, pancreatic	Homo sapiens	193-200
11311125-3	2001	We demonstrate that uPA, associated with the surface of U937 cells, undergoes plasmin-mediated cleavage of the Lys(46)-Ser(47) bond with elimination of the GFD.	Lysine	111-114	plasminogen	Homo sapiens	78-85
11359922-7	2001	Furthermore, mutation of the lysine residues of the cytosolic region of a chimeric receptor carrying the IL2Rbeta targeting signal resulted in a decreased degradation rate.	Lysine	29-35	interleukin 2 receptor, beta chain	Mus musculus	105-113
11096085-8	2001	In contrast, ATP activated a chimera containing the hIK1 C-terminal amino acids His(299)-Lys(427).	Lysine	89-92	potassium calcium-activated channel subfamily N member 4	Homo sapiens	52-56
11318785-5	2001	RESULTS: A novel homozygous missense mutation, at nucleotide 268, turning glutamic acid into lysine, located at the second transmembrane domain of the GnRH-R gene was found in two patients pertaining to one of the families studied.	Lysine	93-99	gonadotropin releasing hormone receptor	Homo sapiens	151-157
11398342-13	2001	The catalytic deficiency of ALDH2 is caused by a structural point mutation at amino acid position 487, where a substitution of Glu to Lys resulting from a transition of G (C) to A (T) at 1510 nucleotide from the initiation codon has occurred.	Lysine	134-137	aldehyde dehydrogenase 2 family member	Homo sapiens	28-33
11341506-8	2001	The lysine analogue EACA inhibits the binding of r-apo(a) to platelets, thus suggesting the involvement of lysine residues in that interaction.	Lysine	4-10	lipoprotein(a)	Homo sapiens	51-57
11341506-8	2001	The lysine analogue EACA inhibits the binding of r-apo(a) to platelets, thus suggesting the involvement of lysine residues in that interaction.	Lysine	107-113	lipoprotein(a)	Homo sapiens	51-57
11083877-14	2001	Defects in human ODC are likely to be a cause of 2-oxoadipate acidemia, an inborn error of metabolism of lysine, tryptophan, and hydroxylysine.	Lysine	105-111	solute carrier family 25 member 21	Homo sapiens	17-20
11099504-0	2001	Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.	Lysine	9-15	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	38-42
11099504-1	2001	We generated mutants of the transporter associated with antigen-processing subunits TAP1 and TAP2 that were altered at the conserved lysine residue in the Walker A motifs of the nucleotide binding domains (NBD).	Lysine	133-139	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	93-97
11067849-1	2001	After the nucleotide binding domain in sarcoplasmic reticulum Ca2+-ATPase has been derivatized with fluorescein isothiocyanate at Lys-515, ATPase phosphorylation in the presence of a calcium gradient, with Ca2+ on the lumenal side but without Ca2+ on the cytosolic side, results in the formation of a species that exhibits exceptionally low probe fluorescence (Pick, U.	Lysine	130-133	dynein axonemal heavy chain 8	Homo sapiens	67-73
11368342-8	2001	At position 2, substitution of Leu by Cha or Phe gave equivalent PAR-2 potency, but this modification also activated PAR-1, whereas Ala, Asp, Lys, or Gln abolished PAR-2 activity; at position 3, Ile and Cha were optimal, although various amino acids were tolerated; at position 4, Ala or Cha increased PAR-2 potency 2-fold, although Cha introduced PAR-1 activity; at position 5, Arg or Lys could be replaced successfully by large hydrophobic amino acids.	Lysine	142-145	F2R like trypsin receptor 1	Homo sapiens	164-169
11368342-8	2001	At position 2, substitution of Leu by Cha or Phe gave equivalent PAR-2 potency, but this modification also activated PAR-1, whereas Ala, Asp, Lys, or Gln abolished PAR-2 activity; at position 3, Ile and Cha were optimal, although various amino acids were tolerated; at position 4, Ala or Cha increased PAR-2 potency 2-fold, although Cha introduced PAR-1 activity; at position 5, Arg or Lys could be replaced successfully by large hydrophobic amino acids.	Lysine	142-145	F2R like trypsin receptor 1	Homo sapiens	164-169
11306098-2	2001	To examine possible differences in the catalytic sites of SPR for exogenous carbonyl compounds and the native pteridine substrates, we investigated by site-directed mutagenesis the role of the highly conserved Ser-Tyr-Lys triad (Ser and YXXXK motif) in SPR, which was shown to be the catalytic site of SDR-family enzymes.	Lysine	218-221	sepiapterin reductase	Homo sapiens	58-61
11945225-1	2001	Ubiquitination is a universal protein degradation pathway in which the molecules of 8.5-kDa proteolytic peptide ubiquitin are covalently attached to the epsilon-amino group of the substrate"s lysine residues.	Lysine	192-198	ubiquitin	Bos taurus	112-121
11120840-2	2000	A predicted model generated from the nuclear magnetic resonance structure of a related protein, NK lysin, suggested that granulysin contains a four alpha helical bundle motif, with the alpha helices enriched for positively charged amino acids, including arginine and lysine residues.	Lysine	267-273	granulysin	Homo sapiens	121-131
11216654-7	2000	Deletion of Lys 191 (del 191) from the hGnRH-R resulted in increased receptor expression levels and decreased internalization rates in both COS-7 and HEK 293 cells.	Lysine	12-15	gonadotropin releasing hormone receptor	Homo sapiens	39-46
11216654-8	2000	In this study, the combined effect of the addition of the C-tail from cfGnRH-R and deletion of the Lys 191 from the hGnRH-R was compared to expression of the wild-type (WT) or either alteration alone in a transient expression system using primate cells.	Lysine	99-102	gonadotropin releasing hormone receptor	Homo sapiens	116-123
11087420-3	2000	The capacity to interact with nNOS correlates with the presence of a Lys residue in the carboxylate- binding loop of these PDZ domains.	Lysine	69-72	nitric oxide synthase 1	Homo sapiens	30-34
11087420-6	2000	PDZ domains with an Arg in the carboxylate-binding loop do not bind nNOS; however, substitution with Lys or Ala was able to confer nNOS binding.	Lysine	101-104	nitric oxide synthase 1	Homo sapiens	131-135
11087420-7	2000	Our results indicate that the carboxylate-binding loop Lys or Arg is a critical determinant of nNOS binding and that the identity of this residue can profoundly alter one mode of PDZ recognition without affecting another.	Lysine	55-58	nitric oxide synthase 1	Homo sapiens	95-99
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Lysine	96-99	carboxypeptidase B2	Homo sapiens	0-4
11215380-3	2000	One of its target substrates is the C-terminal Lys residue in the alpha-chain of plasmin-digested fibrin, which is critical for plasminogen binding to fibrin.	Lysine	47-50	plasminogen	Homo sapiens	81-88
1898739-4	1991	Our kinetic data are consistent with a formal mechanism of action for carbonic anhydrase III that is directly analogous to that of carbonic anhydrase II, in which Lys-64 of carbonic anhydrase III can act as an intramolecular H+ transfer group during CO2 hydration.	Lysine	163-166	carbonic anhydrase 3	Bos taurus	70-92
1898739-4	1991	Our kinetic data are consistent with a formal mechanism of action for carbonic anhydrase III that is directly analogous to that of carbonic anhydrase II, in which Lys-64 of carbonic anhydrase III can act as an intramolecular H+ transfer group during CO2 hydration.	Lysine	163-166	carbonic anhydrase 2	Bos taurus	70-91
1898739-4	1991	Our kinetic data are consistent with a formal mechanism of action for carbonic anhydrase III that is directly analogous to that of carbonic anhydrase II, in which Lys-64 of carbonic anhydrase III can act as an intramolecular H+ transfer group during CO2 hydration.	Lysine	163-166	carbonic anhydrase 3	Bos taurus	173-195
1985948-6	1991	In cultured human fibroblasts, CsA caused posttranslational overmodification (hydroxylation of lysine 32.1 versus 22.1%) and increased intracellular degradation (18.7 versus 12.5%), and hence decreased production (10.2 versus 13.2% of total protein synthesis) of collagens I and III, indicating that procollagen folding is slowed by CsA also in human fibroblasts.	Lysine	95-101	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	31-34
1647004-2	1991	Acylation of the epsilon-amino group in lysine 13 by a hydrophobic moiety is well tolerated in terms of bioactivity: the analog [Nle8,18, D-Trp12,Lys 13 (epsilon-3-phenylpropanoyl),Tyr34]bPTH(7-34)NH2 is equivalent to the parent peptide in its affinity for PTH receptors and its ability to inhibit PTH-stimulated adenylate cyclase in both kidney- and bone-based assays.	Lysine	40-46	transient receptor potential cation channel subfamily V member 4	Homo sapiens	140-145
2123490-0	1990	Mutagenesis of lysine 460 in the human insulin receptor.	Lysine	15-21	insulin receptor	Homo sapiens	39-55
1701396-4	1990	Incubation of porin with fluorescein isothiocyanate (FITC) resulted in the isolation of a porin fraction in which on average two lysines located on the surface of the pore-forming complex per 35 kDa polypeptide were modified.	Lysine	129-136	voltage dependent anion channel 1	Homo sapiens	14-19
1701396-4	1990	Incubation of porin with fluorescein isothiocyanate (FITC) resulted in the isolation of a porin fraction in which on average two lysines located on the surface of the pore-forming complex per 35 kDa polypeptide were modified.	Lysine	129-136	voltage dependent anion channel 1	Homo sapiens	90-95
1701396-6	1990	The experiments presented here give the first biochemical evidence that positively charged lysine residues located on the surface of the channel-forming complex are responsible for the gating of the mitochondrial porin-channel.	Lysine	91-97	voltage dependent anion channel 1	Homo sapiens	213-218
2149860-1	1990	Partially purified selenoprotein P from rat plasma was digested with either trypsin, endoprotease Lys-C, or endoprotease Arg-C and analyzed by high pressure liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis.	Lysine	98-101	selenoprotein P	Rattus norvegicus	19-34
2145977-3	1990	The normalized energy transfer efficiency between AEDANS bound at cysteine-670 and -674 and FITC bound at lysine-515 increases with increasing temperature in the range of 10-37 degrees C, indicating the existence of a relatively flexible structure in the region of the ATPase molecule that links the AEDANS to the FITC site.	Lysine	106-112	dynein axonemal heavy chain 8	Homo sapiens	269-275
2209542-1	1990	The N-end rule-based degradation signal, which targets a protein for ubiquitin-dependent proteolysis, comprises a destabilizing amino-terminal residue and a specific internal lysine residue.	Lysine	175-181	ubiquitin	Saccharomyces cerevisiae S288C	69-78
2117703-1	1990	The N-terminal serine and four conserved lysine residues near the N-terminus of yeast histone H4 are acetylated.	Lysine	41-47	histone H4	Saccharomyces cerevisiae S288C	86-96
2143190-6	1990	In this paper, the structural and functional role of the lysine and arginine residues of the TCR alpha chain was addressed using oligonucleotide mediated site directed mutagenesis.	Lysine	57-63	T cell receptor alpha constant	Homo sapiens	93-102
2144871-2	1990	Lp[a] was purified from donors with various genetic polymorphic forms by affinity chromatography using lysine-Sepharose or specific immunoadsorbers.	Lysine	103-109	lipoprotein(a)	Homo sapiens	0-4
2114171-9	1990	Harmaline also has been found by other investigators to competitively inhibit L-lysine uptake by the Na(+)-independent system asc1 in horse erythrocytes, whereas it noncompetitively inhibits alanine uptake by the same system.	Lysine	78-86	solute carrier family 7 member 10	Homo sapiens	126-130
2162343-8	1990	The amino acid sequence surrounding this lysine residue labeled by both reagents is highly conserved in (Na,K)-ATPase and the related (H,K)-ATPase sequences thus far obtained, which may signify a functional importance for this region of the putative ATP-binding site in these transport proteins.	Lysine	41-47	dynein axonemal heavy chain 8	Homo sapiens	126-146
2114094-10	1990	Chemical modification of collagen lysine residues indicates that specific lysine residues may be involved in Mg2(+)-dependent adhesion.	Lysine	34-40	mucin 7, secreted	Homo sapiens	109-112
2114094-10	1990	Chemical modification of collagen lysine residues indicates that specific lysine residues may be involved in Mg2(+)-dependent adhesion.	Lysine	74-80	mucin 7, secreted	Homo sapiens	109-112
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Lysine	99-102	thyrotropin releasing hormone	Homo sapiens	0-3
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Lysine	123-126	thyrotropin releasing hormone	Homo sapiens	0-3
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Lysine	97-100	insulin receptor	Homo sapiens	3-19
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	206-209	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
2157138-2	1990	We therefore examined the ability of a CSF-1R carboxy-terminal truncation mutant to phosphorylate a kinase-defective receptor, CSF-1R[met 616], that contains a methionine-for-lysine substitution at its ATP-binding site.	Lysine	175-181	colony stimulating factor 1 receptor	Homo sapiens	39-45
2157138-2	1990	We therefore examined the ability of a CSF-1R carboxy-terminal truncation mutant to phosphorylate a kinase-defective receptor, CSF-1R[met 616], that contains a methionine-for-lysine substitution at its ATP-binding site.	Lysine	175-181	colony stimulating factor 1 receptor	Homo sapiens	127-133
2140397-1	1990	Human Lp[a] can be fractionated into two species with different affinities for lysine-Sepharose.	Lysine	79-85	lipoprotein(a)	Homo sapiens	6-10
1693271-5	1990	The amino acid composition of PAPP-A differed most significantly from alpha 2M, in the content of glutamate, glycine and lysine.	Lysine	121-127	pappalysin 1	Homo sapiens	30-36
2140680-0	1990	Modifications to the lysine Sepharose method of plasminogen purification which ensure plasmin-free Glu-plasminogen.	Lysine	21-27	plasminogen	Homo sapiens	48-55
2157180-1	1990	Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not.	Lysine	270-276	colony stimulating factor 1 receptor	Homo sapiens	40-76
2157180-1	1990	Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not.	Lysine	270-276	colony stimulating factor 1 receptor	Homo sapiens	78-84
33793773-8	2021	We identified two alternative forms of regulation both with the potential to act via lysine residues, including acetylation by Gcn5 and ubiquitination by the Not4 ligase.	Lysine	85-91	CCR4-NOT core ubiquitin-protein ligase subunit MOT2	Saccharomyces cerevisiae S288C	158-162
33782381-12	2021	Mechanistic research indicated that CREB and histone H4 lysine 20 methylation (H4K20me1, a downstream target of KMT5A) occupy the PTP1B promoter region.	Lysine	56-62	lysine methyltransferase 5A	Homo sapiens	112-117
33589814-2	2021	We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the complex selectively ubiquitylates lysines 125, 127 and 129 in the flexible C-terminal tail of H2A in a fully human system.	Lysine	216-223	H2A clustered histone 18	Homo sapiens	276-279
33588906-2	2021	NSD1 encodes a histone 3 lysine-36 methyltransferase.	Lysine	25-31	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
33232875-1	2021	NEDDylation is a post-translational modification of a protein, which transfers Ubiquitin like protein NEDD8 (Neuronal Precursor Cell-expressed Developmentally Down-regulated Protein 8) to the lysine residue of the product through a three-stage enzymatic reaction, and widely regulates many biological processes, such as cell cycle signal transduction and immune recognition.	Lysine	192-198	NEDD8 ubiquitin like modifier	Homo sapiens	102-107
33232875-1	2021	NEDDylation is a post-translational modification of a protein, which transfers Ubiquitin like protein NEDD8 (Neuronal Precursor Cell-expressed Developmentally Down-regulated Protein 8) to the lysine residue of the product through a three-stage enzymatic reaction, and widely regulates many biological processes, such as cell cycle signal transduction and immune recognition.	Lysine	192-198	NEDD8 ubiquitin like modifier	Homo sapiens	109-183
33778323-3	2021	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of cross-linking lysine residues in fibrillar collagen telopeptide domains.	Lysine	112-118	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-5
33778323-3	2021	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of cross-linking lysine residues in fibrillar collagen telopeptide domains.	Lysine	112-118	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	18-37
33778323-3	2021	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of cross-linking lysine residues in fibrillar collagen telopeptide domains.	Lysine	112-118	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	39-42
33768140-6	2021	USP7 enhanced the ubiquitination of Jumonji domain-containing protein D3 (JMJD3), elevated JMJD3-promoted growth of EC cells, and transcriptionally activated clusterin (CLU) expression at the promoter region via histone H3 lysine 27 tri-methyl (H3K27me3) demethylation, according to immunoprecipitation and ubiquitination assays.	Lysine	223-229	clusterin	Homo sapiens	158-167
24052902-6	2013	To gain such potential insights in a biological context, we analyzed two most prevalent PTMs on the lysine residue by acetylation and ubiquitylation along with the most abundant PTM in proteins by phosphorylation among enzymes involved in glucose metabolism, a fundamental process in biology.	Lysine	100-106	parathymosin	Homo sapiens	88-92
34741939-5	2022	The inhibition of mitochondrial activity and increase in HDAC2 and MTA3 dysregulated the lysine acetylation levels of histone and global proteins.	Lysine	89-95	metastasis associated 3	Mus musculus	67-71
34497325-2	2022	Polycomb group ring finger protein 1 (Pcgf1) is a component of PRC1.1, a non-canonical PRC1 that monoubiquitylates H2A at lysine 119 (H2AK119ub1).	Lysine	122-128	polycomb group ring finger 1	Mus musculus	0-36
34497325-2	2022	Polycomb group ring finger protein 1 (Pcgf1) is a component of PRC1.1, a non-canonical PRC1 that monoubiquitylates H2A at lysine 119 (H2AK119ub1).	Lysine	122-128	polycomb group ring finger 1	Mus musculus	38-43
34958593-3	2022	Here, for the first time, we applied a CBT-Cys click condensation reaction to synthesize an acidity-initiated molecular probe (AIM-Probe, Cys(StBu)-Lys(Cy 5.5)-EDA-PMA-CBT), which could self-assemble into nanoparticles (AIM-NP) with self-quenched fluorescence under glutathione (GSH) reduction.	Lysine	148-151	ectodysplasin A	Homo sapiens	160-163
34860252-4	2022	We show that pVHL directly interacts with conserved lysine and proline residues in the MH2 domain of SMAD3, triggering degradation.	Lysine	52-58	von Hippel-Lindau tumor suppressor	Homo sapiens	13-17
34491605-2	2022	METHODS: We constructed novel unimolecular dual agonists of GLP-1R and glucagon receptor prepared by linking sEx-4 and native glucagon (GCG) via lysine or triazole (sEx4-GCG(K) and sEx4-GCG(T), respectively) and evaluated their anti-obesity and anti-diabetic efficacy in diabetic and obese mouse model.	Lysine	145-151	glucagon receptor	Mus musculus	71-88
34491605-2	2022	METHODS: We constructed novel unimolecular dual agonists of GLP-1R and glucagon receptor prepared by linking sEx-4 and native glucagon (GCG) via lysine or triazole (sEx4-GCG(K) and sEx4-GCG(T), respectively) and evaluated their anti-obesity and anti-diabetic efficacy in diabetic and obese mouse model.	Lysine	145-151	glucagon	Mus musculus	126-134
34491605-2	2022	METHODS: We constructed novel unimolecular dual agonists of GLP-1R and glucagon receptor prepared by linking sEx-4 and native glucagon (GCG) via lysine or triazole (sEx4-GCG(K) and sEx4-GCG(T), respectively) and evaluated their anti-obesity and anti-diabetic efficacy in diabetic and obese mouse model.	Lysine	145-151	glucagon	Mus musculus	136-139
34826170-7	2022	Melatonin-induced OTUD1 upregulation caused deubiquitnation at the lysine 3 residue of Bim, resulting in its stabilization.	Lysine	67-73	OTU deubiquitinase 1	Homo sapiens	18-23
34890965-6	2022	Epigenetic repression of CDK4 and CDK6 by nafamostat mesylate induced apoptosis and suppressed the metastasis of ERPBC through the deacetylation of Histone 3 Lysine 27.	Lysine	158-164	cyclin dependent kinase 4	Homo sapiens	25-29
34902970-2	2021	Herein, a smart nanocarrier (designated as mP-NPs-DNase/PTX) based on regulating tumor-associated NETs has been developed, which consists of a paclitaxel (PTX) prodrug nanoparticle core and a poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell.	Lysine	192-205	tyrosine aminotransferase	Homo sapiens	277-280
34908107-7	2022	siRNAs for MAB21L4 did not inhibit the binding of Smad3 to their target genomic regions but down-regulated the acetylation of histone H3 lys 27 (H3K27ac), an active mark, near the Smad3 binding regions.	Lysine	137-140	SMAD family member 3	Homo sapiens	180-185
34698396-7	2021	Oligomerization-induced MLKL ubiquitylation occurs on at least four separate lysine residues and correlates with its proteasome- and lysosome-dependent turnover.	Lysine	77-83	mixed lineage kinase domain like pseudokinase	Homo sapiens	24-28
34586553-1	2021	Enteropeptidase is a duodenum serine protease that triggers the activation of pancreatic enzymes by remarkably specific cleavages after lysine residues of peptidyl substrate (Asp)4-Lys.	Lysine	136-142	transmembrane serine protease 15	Bos taurus	0-15
34807744-0	2021	Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice.	Lysine	19-25	sirtuin 5	Mus musculus	0-9
34807744-8	2021	The expression and desuccinylation activity of Sirt5, lysine succinylation of citrate synthase and ATP synthase subunits were investigated by Western blot, immunohistochemistry, and ELISA in SAH mice and patients.	Lysine	54-60	citrate synthase	Mus musculus	78-94
34807744-16	2021	CONCLUSIONS: Protein lysine succinylation is a biochemical hallmark of metabolic crisis after SAH, and disruption of lysine succinylation through activation of Sirt5 might be a promising therapeutic strategy for the treatment of SAH.	Lysine	21-27	sirtuin 5	Mus musculus	160-165
34807744-16	2021	CONCLUSIONS: Protein lysine succinylation is a biochemical hallmark of metabolic crisis after SAH, and disruption of lysine succinylation through activation of Sirt5 might be a promising therapeutic strategy for the treatment of SAH.	Lysine	117-123	sirtuin 5	Mus musculus	160-165
34909768-8	2021	Differential expression was paralleled by changes in histone H3 lysine residue 4 trimethylation at the promoters of DEGs at 1 day post-TBI, with the strongest changes observed for inflammation and immune response genes.	Lysine	64-70	delta(4)-desaturase, sphingolipid 1	Rattus norvegicus	116-120
34758883-10	2021	In addition, biological experiments proved that the downregulation of EPB41L4A-AS1 could reduce the expression of these genes via histone H3 lysine 27 acetylation, resulting in decreased NAD+ and ATP levels, while EPB41L4A-AS1 overexpression and nicotinamide riboside treatment could restore the NAD+ and ATP levels.	Lysine	141-147	EPB41L4A antisense RNA 1	Homo sapiens	70-82
34237635-0	2021	Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.	Lysine	57-63	lysine demethylase 4D	Homo sapiens	76-81
34126877-5	2021	Among them was NLR Family Pyrin Domain Containing 2 (NLRP2) forming a SecoA-protein adduct at lysine (K1019) in the terminal leucine-rich-repeat, a known regulatory region for NLR proteins.	Lysine	94-100	NLR family pyrin domain containing 2	Homo sapiens	15-51
34126877-5	2021	Among them was NLR Family Pyrin Domain Containing 2 (NLRP2) forming a SecoA-protein adduct at lysine (K1019) in the terminal leucine-rich-repeat, a known regulatory region for NLR proteins.	Lysine	94-100	NLR family pyrin domain containing 2	Homo sapiens	53-58
34088983-2	2021	The ubiquitin ligases RNF20 and RNF40 mediate the monoubiquitination of histone H2B at lysine 120 (H2Bub1) and were shown to play context-dependent roles in the development of inflammation.	Lysine	87-93	ring finger protein 20	Mus musculus	22-27
34089566-2	2021	Here, we show that PKCdelta is SUMOylated at lysine 473 in its C-terminal catalytic domain, and the SUMOylation increases PKCdelta stability by repressing its ubiquitination.	Lysine	45-51	protein kinase C delta	Homo sapiens	19-27
34662580-2	2021	Nedd8 attaches to a lysine residue of a substrate, not for degradation, but for modulation of substrate activity.	Lysine	20-26	NEDD8 ubiquitin like modifier	Homo sapiens	0-5
34725436-1	2021	Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes.	Lysine	54-60	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	26-30
34769235-2	2021	Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latter of which is supported by structural studies.	Lysine	19-25	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	62-67
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	lysine acetyltransferase 8	Homo sapiens	200-226
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	lysine acetyltransferase 8	Homo sapiens	228-232
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	150-153	lysine acetyltransferase 8	Homo sapiens	200-226
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	150-153	lysine acetyltransferase 8	Homo sapiens	228-232
34555477-3	2021	Herein, we modify neoantigen peptide (Adpgk) derived from MC-38 colon carcinoma by supplementing ten consecutive positively-charged lysine (10K-Adpgk) to obtain cationic polypeptide.	Lysine	132-138	ADP-dependent glucokinase	Mus musculus	144-149
34642466-0	2022	Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage.	Lysine	64-70	sirtuin 5	Mus musculus	30-35
34763954-6	2021	Additionally, trimethylation of histone H3 Lysine 4 (H3K4me3) was decreased in the A20 promoter of SLE B cells.	Lysine	43-49	TNF alpha induced protein 3	Homo sapiens	83-86
34615858-1	2021	The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation and progression of human cancer.	Lysine	88-94	nuclear receptor binding SET domain protein 3	Homo sapiens	4-41
34615858-1	2021	The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation and progression of human cancer.	Lysine	88-94	nuclear receptor binding SET domain protein 3	Homo sapiens	43-47
11044771-4	2000	We randomly treated preterm lambs (gestational age 127-129 days) with either 16 mg of lysine-plasminogen (n = 10) or saline (n = 10), and ventilated them for 5 h. There were no significant differences in physiologic measurements of lung function (ventilation efficiency index, oxygenation index, dynamic compliance, quasi-static pressure volume curve), measures of lung injury (alveolar wash protein content and (125)I-albumin recovery) or surfactant pool size.	Lysine	86-92	plasminogen	Homo sapiens	93-104
11034396-9	2000	Intriguingly, all 10 Vkappa1C hybridomas share a lysine to glutamate mutation in the CDR1.	Lysine	49-55	cerebellar degeneration related antigen 1	Mus musculus	85-89
10982821-1	2000	Hat1p and Hat2p are the two subunits of a type B histone acetyltransferase from Saccharomyces cerevisiae that acetylates free histone H4 on lysine 12 in vitro.	Lysine	140-146	Hat2p	Saccharomyces cerevisiae S288C	10-15
34251718-9	2021	MLL recruits p300/CBP through its transcriptional activation domain, which acetylates histone H3 at lysines 9, 18, and 27.	Lysine	100-107	E1A binding protein p300	Homo sapiens	13-17
19589784-4	2009	We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro.	Lysine	55-58	FA complementation group L	Homo sapiens	76-81
11020349-1	2000	Protein transduction domains (PTDs), such as the third helix of the Drosophila Antennapedia homeobox gene (Antp) and the HIV TAT PTD, possess a characteristic positive charge on the basis of their enrichment for arginine and lysine residues.	Lysine	225-231	Antennapedia	Drosophila melanogaster	107-111
19706513-3	2009	We showed previously that growth factor-induced phosphorylation of PR Ser-294 blocks PR Lys-388 sumoylation.	Lysine	88-91	progesterone receptor	Homo sapiens	67-69
10878019-15	2000	We conclude that mutation of a conserved lysine residue to glutamate in Galpha(i) and Galpha(q) family members renders these proteins insensitive to wild type RGS proteins.	Lysine	41-47	G protein subunit alpha q	Rattus norvegicus	86-95
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Lysine	121-127	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	11-12
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Lysine	121-127	neuropilin 1	Homo sapiens	30-42
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Lysine	121-127	neuropilin 1	Homo sapiens	44-48
19706513-3	2009	We showed previously that growth factor-induced phosphorylation of PR Ser-294 blocks PR Lys-388 sumoylation.	Lysine	88-91	progesterone receptor	Homo sapiens	85-87
19706513-8	2009	Notably, ChIP assays demonstrated that K388R PR-B and SRC1 were constitutively recruited to the STC1 promoter in the absence of progestin; PR Lys-388 sumoylation was required for HDAC3 recruitment.	Lysine	142-145	histone deacetylase 3	Homo sapiens	179-184
10859319-6	2000	NH(2)-terminal amino acid sequencing revealed that MMP-12 cleaved TFPI at Lys(20)-Leu(21)(close to Kunitz I domain and producing a 35-kDa band), Arg(83)-Ile(84) (between Kunitz I and II domains), and Ser(174)-Thr(175) (between Kunitz II and III domains).	Lysine	74-77	tissue factor pathway inhibitor	Homo sapiens	66-70
10859319-7	2000	MMP-7 and MMP-9 cleaved TFPI at Lys(20)-Leu(21) with additional COOH-terminal processing.	Lysine	32-35	tissue factor pathway inhibitor	Homo sapiens	24-28
34590685-3	2022	Here, a biomarker is reported for histone lysine methyltransferase (KMT2B)-deficient dystonia, a leading subtype among the individually rare monogenic dystonias.	Lysine	42-48	lysine methyltransferase 2B	Homo sapiens	68-73
19672304-5	2009	Methylation of H3 at lysine 4 coincided with DXZ1 higher order alpha satellite, the site of CENP-A localization.	Lysine	21-27	centromere protein A	Homo sapiens	92-98
34591986-9	2022	Through immunoprecipitation-mass spectrometry (IP-MS) analysis, we further found that OTUB1 directly bound to tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppressed its lysine 63 (K63)-linked polyubiquitination, thus inhibiting the activation of ASK1 and its downstream pathway.	Lysine	188-194	OTU domain, ubiquitin aldehyde binding 1	Mus musculus	86-91
34795154-1	2021	We previously reported that hepatitis C virus (HCV) NS5A (1b, Con1) protein accepts covalent ISG15 conjugation at specific lysine (Lys) residues (K44, K68, K166, K215 and K308), exhibiting proviral effects on HCV RNA replication.	Lysine	123-129	ISG15 ubiquitin like modifier	Homo sapiens	93-98
34795154-1	2021	We previously reported that hepatitis C virus (HCV) NS5A (1b, Con1) protein accepts covalent ISG15 conjugation at specific lysine (Lys) residues (K44, K68, K166, K215 and K308), exhibiting proviral effects on HCV RNA replication.	Lysine	131-134	ISG15 ubiquitin like modifier	Homo sapiens	93-98
34712915-5	2021	FKBP12 is acetylated on the lysine cluster (K45/K48/K53) by CREB-binding protein (CBP) in mammalian cells in response to nutrient treatment.	Lysine	28-34	FKBP prolyl isomerase 1A	Homo sapiens	0-6
11881039-0	2000	Lys(199) mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists.	Lysine	0-3	angiotensin II receptor type 1	Homo sapiens	31-58
11019956-3	2000	CPU removes C-terminal lysine residues that act as plasminogen binding sites from partially degraded fibrin, thereby down-regulating plasminogen activation and fibrinolysis.	Lysine	23-29	carboxypeptidase B2	Homo sapiens	0-3
19506301-2	2009	In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death.	Lysine	129-132	granzyme A	Homo sapiens	28-32
19506301-2	2009	In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death.	Lysine	129-132	granzyme A	Homo sapiens	263-267
10825173-6	2000	The importance of the lysine side chains was corroborated by the finding that the fibrillin-2 construct did not bind to mature elastin, whose lysine side chains have been modified to form cross-links.	Lysine	22-28	fibrillin 2	Homo sapiens	82-93
34551289-5	2021	Accordingly, key PAX8 target genes are repressed in RCC versus normal kidneys, with the loss of histone lysine-27 acetylation, but intact lysine-4 trimethylation, activation marks.	Lysine	104-110	paired box 8	Homo sapiens	17-21
19506301-2	2009	In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death.	Lysine	129-132	granzyme A	Homo sapiens	263-267
19131641-4	2009	mTORC1 was dose- and time-dependently activated in murine bone marrow neutrophils cultured with the TLR4 ligand, LPS, or the TLR2 ligand, Pam(3) Cys-Ser-(Lys)(4) (PAM).	Lysine	154-157	CREB regulated transcription coactivator 1	Mus musculus	0-6
34782858-2	2021	Urm1 is dual-functional, acting both as a sulfur carrier for thiolation of tRNA anticodons and as a protein modifier in a lysine-directed Ub-like conjugation also known as urmylation.	Lysine	122-128	ubiquitin related modifier 1	Homo sapiens	0-4
34782858-4	2021	An in-depth study of Ahp1 urmylation in yeast from our laboratory (Brachmann et al., 2020) uncovered that promiscuous lysine target sites and specific redox requirements determine the Urm1 acceptor activity of the peroxiredoxin.	Lysine	118-124	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	21-25
34782858-4	2021	An in-depth study of Ahp1 urmylation in yeast from our laboratory (Brachmann et al., 2020) uncovered that promiscuous lysine target sites and specific redox requirements determine the Urm1 acceptor activity of the peroxiredoxin.	Lysine	118-124	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	184-188
10913172-5	2000	To determine whether the NTP-binding motif is important for Rad24 function, we mutated the conserved lysine(115) residue in this motif.	Lysine	101-107	Rad24p	Saccharomyces cerevisiae S288C	60-65
10913172-6	2000	The rad24-K115E mutation, which changes lysine to glutamate, confers a complete loss-of-function phenotype, while the rad24-K115R mutation, which changes lysine to arginine, shows no apparent phenotype.	Lysine	40-46	Rad24p	Saccharomyces cerevisiae S288C	4-9
34603379-5	2021	Sequence alignment shows that the Lys 624 residue of SIPA1L3 is conserved across the species.	Lysine	34-37	signal induced proliferation associated 1 like 3	Homo sapiens	53-60
19131641-4	2009	mTORC1 was dose- and time-dependently activated in murine bone marrow neutrophils cultured with the TLR4 ligand, LPS, or the TLR2 ligand, Pam(3) Cys-Ser-(Lys)(4) (PAM).	Lysine	154-157	toll-like receptor 2	Mus musculus	125-129
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	RAP1 GTPase activating protein	Homo sapiens	40-47
10779504-3	2000	p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-terminal to the zinc finger DNA-binding domain.	Lysine	92-98	E1A binding protein p300	Homo sapiens	0-4
19131641-4	2009	mTORC1 was dose- and time-dependently activated in murine bone marrow neutrophils cultured with the TLR4 ligand, LPS, or the TLR2 ligand, Pam(3) Cys-Ser-(Lys)(4) (PAM).	Lysine	154-157	peptidylglycine alpha-amidating monooxygenase	Mus musculus	138-141
10779504-3	2000	p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-terminal to the zinc finger DNA-binding domain.	Lysine	92-98	E1A binding protein p300	Homo sapiens	9-13
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	RAP1 GTPase activating protein	Homo sapiens	153-160
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	RAP1 GTPase activating protein	Homo sapiens	247-254
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	RAP1 GTPase activating protein	Homo sapiens	40-47
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	RAP1 GTPase activating protein	Homo sapiens	153-160
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	RAP1 GTPase activating protein	Homo sapiens	247-254
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	25-28	SMAD family member 4	Homo sapiens	92-96
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	25-28	SMAD family member 3	Homo sapiens	185-191
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	25-28	SMAD family member 3	Homo sapiens	227-233
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 4	Homo sapiens	92-96
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	185-191
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	227-233
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 4	Homo sapiens	92-96
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	185-191
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	227-233
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 4	Homo sapiens	92-96
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	185-191
10884415-3	2000	An NLS-like basic motif (Lys(40)-Lys-Leu-Lys-Lys(44)), conserved among all pathway-specific Smad proteins, not only is responsible for constitutive nuclear localization of the isolated Smad 3 MH1 domain but also is crucial for Smad 3 nuclear import in response to ligand.	Lysine	33-36	SMAD family member 3	Homo sapiens	227-233
10884415-6	2000	Smad 4, which cannot translocate into the nucleus in the absence of Smad 3 or another pathway-specific Smad, contains a Glu in place of the last Lys in this motif.	Lysine	145-148	SMAD family member 4	Homo sapiens	0-6
10884415-6	2000	Smad 4, which cannot translocate into the nucleus in the absence of Smad 3 or another pathway-specific Smad, contains a Glu in place of the last Lys in this motif.	Lysine	145-148	SMAD family member 4	Homo sapiens	0-4
10770943-5	2000	PDZ2 mutations have more pronounced effects on binding than PDZ1 mutations, but complete abrogation of syntenin-syndecan binding requires the combination of both the lysine and the alphaB1 mutations in both the PDZ domains of syntenin.	Lysine	166-172	syndecan 1	Homo sapiens	112-120
10852958-7	2000	Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function.	Lysine	56-62	cut like homeobox 1	Homo sapiens	15-22
10852958-7	2000	Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	26-30
10852958-7	2000	Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function.	Lysine	56-62	cut like homeobox 1	Homo sapiens	114-121
10751404-7	2000	We also found that a conserved Lys residue required for PP5 binding to hsp90 was critical for the binding of FKBP52 but not for the binding of Hop to hsp90.	Lysine	31-34	protein phosphatase 5 catalytic subunit	Homo sapiens	56-59
18726387-7	2000	The ASYIP protein contains a C-terminal endoplasmic reticulum retrieval signal (Lys-Lys-Lys-Ala-Glu).	Lysine	84-87	reticulon 3	Homo sapiens	4-9
10799544-4	2000	Stoichiometric binding of SK to native Pm was followed by generation of a two-fragment form of SK cleaved at Lys(59) (SK"), which exhibited an indistinguishable affinity for labeled Pm, while a truncated, SK(55-414) species had a 120-360-fold reduced affinity.	Lysine	109-112	plasminogen	Homo sapiens	39-41
10788439-9	2000	The SUMO-1 attachment site in p53 (Lys-386) resides within a region known to regulate the DNA binding activity of the protein.	Lysine	35-38	small ubiquitin like modifier 1	Homo sapiens	4-10
10867710-0	2000	Ionization state and molecular docking studies for the macrophage migration inhibitory factor: the role of lysine 32 in the catalytic mechanism.	Lysine	107-113	macrophage migration inhibitory factor	Homo sapiens	55-93
10801418-8	2000	Mutagenesis of the glycine, as well as the lysine, severely impaired Rch1 acetylation, supporting the view that GK is part of a recognition motif for acetylation by CBP/p300.	Lysine	43-49	karyopherin subunit alpha 2	Homo sapiens	69-73
10727403-8	2000	This finding points to a catalytic mechanism in which the abstraction and re-addition of C-5 protons are effected by two polyprotic bases, presumably lysine residues.	Lysine	150-156	complement C5	Bos taurus	89-92
10686274-3	2000	The active form - CPU - is able to retard the initial phase of fibrinolysis by cleaving C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin.	Lysine	99-105	carboxypeptidase B2	Homo sapiens	18-21
10686274-3	2000	The active form - CPU - is able to retard the initial phase of fibrinolysis by cleaving C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin.	Lysine	99-105	plasminogen	Homo sapiens	169-176
10686274-4	2000	These C-terminal lysine residues are essential for the high affinity binding of plasminogen to fibrin and the subsequent activation to plasmin.	Lysine	17-23	plasminogen	Homo sapiens	80-87
10669658-7	2000	These studies provide the first quantitative evidence that binding of Lp(a) to lysine residues of fibrin and cell surfaces is directly related to circulating levels of both plasminogen and Lp(a) and that these glycoproteins may interact as competitive ligands for these biological surfaces in vivo.	Lysine	79-85	lipoprotein(a)	Homo sapiens	70-75
10669658-7	2000	These studies provide the first quantitative evidence that binding of Lp(a) to lysine residues of fibrin and cell surfaces is directly related to circulating levels of both plasminogen and Lp(a) and that these glycoproteins may interact as competitive ligands for these biological surfaces in vivo.	Lysine	79-85	lipoprotein(a)	Homo sapiens	189-194
10652256-7	2000	The HNE-mediated activation of caspases, cleavage of PARP and DNA fragmentation were blocked by antioxidants cysteine, N-acety-L-cysteine and dithiothreitol, but not by two other HNE-reactive amino acids lysine and histidine, or by cystine, the oxidized form of cysteine.	Lysine	204-210	caspase 8	Homo sapiens	31-39
10633045-5	2000	The anilino group of the CDK2-bound compound was essentially coplanar with the quinazoline ring system and occupied a pocket between Lys-33 and Phe-80.	Lysine	133-136	cyclin dependent kinase 2	Homo sapiens	25-29
10607594-5	1999	The major targets of acetylation by p300 are lysine residues (Lys50 and Lys51) in the arginine-rich motif (ARM) used by Tat to bind RNA and for nuclear import.	Lysine	45-51	E1A binding protein p300	Homo sapiens	36-40
10607594-5	1999	The major targets of acetylation by p300 are lysine residues (Lys50 and Lys51) in the arginine-rich motif (ARM) used by Tat to bind RNA and for nuclear import.	Lysine	45-51	tyrosine aminotransferase	Homo sapiens	120-123
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Lysine	31-37	tyrosine aminotransferase	Homo sapiens	127-130
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Lysine	31-37	E1A binding protein p300	Homo sapiens	135-139
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Lysine	31-37	tyrosine aminotransferase	Homo sapiens	146-149
10625453-6	1999	In addition, a unique lysine residue on the Cdc42-binding domain of ACK-2 (GBD-ACK) was covalently modified with a fluorescent succinimidyl ester.	Lysine	22-28	cell division cycle 42	Homo sapiens	44-49
10625453-7	1999	The distances separating this reactive lysine from the nucleotide binding site and lysine 150 of Cdc42 were determined by fluorescence resonance energy transfer and yielded a picture for Cdc42/GBD-ACK interactions that is consistent with recent NMR structural determinations for Cdc42/effector complexes.	Lysine	39-45	cell division cycle 42	Homo sapiens	187-192
10625453-7	1999	The distances separating this reactive lysine from the nucleotide binding site and lysine 150 of Cdc42 were determined by fluorescence resonance energy transfer and yielded a picture for Cdc42/GBD-ACK interactions that is consistent with recent NMR structural determinations for Cdc42/effector complexes.	Lysine	39-45	cell division cycle 42	Homo sapiens	279-293
10625453-7	1999	The distances separating this reactive lysine from the nucleotide binding site and lysine 150 of Cdc42 were determined by fluorescence resonance energy transfer and yielded a picture for Cdc42/GBD-ACK interactions that is consistent with recent NMR structural determinations for Cdc42/effector complexes.	Lysine	83-89	cell division cycle 42	Homo sapiens	97-102
10562558-3	1999	A lysine residue at amino acid position 386 of p53 is required for this previously undescribed modification, strongly suggesting that this lysine residue serves as the major attachment site for SUMO-1.	Lysine	2-8	small ubiquitin like modifier 1	Homo sapiens	194-200
10562558-3	1999	A lysine residue at amino acid position 386 of p53 is required for this previously undescribed modification, strongly suggesting that this lysine residue serves as the major attachment site for SUMO-1.	Lysine	139-145	small ubiquitin like modifier 1	Homo sapiens	194-200
10531419-9	1999	We demonstrate that LY 294002, but not PD 98059, prevents GDNF-, neurturin-, and persephin-induced motoneuron survival, suggesting that PI 3-kinase intracellular pathway is responsible in mediating the neurotrophic effect.	Lysine	20-22	glial cell derived neurotrophic factor	Gallus gallus	58-62
10608664-1	1999	Dihydrodipicolinate synthase (DHPS) is the main enzyme of a specific branch of the aspartate pathway leading to lysine biosynthesis in higher plants.	Lysine	112-118	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	30-34
10608664-7	1999	Steady-state levels of DHPS mRNA were slightly reduced in the endosperms and embryos of the maize lysine-rich opaque2 mutants when compared with those in normal kernels.	Lysine	98-104	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	23-27
10529174-8	1999	The sequence analysis of the four mutant mna6 alleles revealed that Leu(109) --&gt; Phe, Arg(111) --&gt; Lys, Pro(424) --&gt; Leu, or Pro(438) --&gt; Leu amino acid substitution in Mna6p causes temperature-dependent loss of the 15S rRNA.	Lysine	105-108	mitochondrial 37S ribosomal protein NAM9	Saccharomyces cerevisiae S288C	41-45
10493908-8	1999	In contrast, the peptides with a position 2 (P2) lysine mutation, IGF-I(66-75)Lys(70) and IGF-II(63-72)Lys(67), were cleaved more efficiently by PC1 and furin compared with rPC4A.	Lysine	49-55	furin, paired basic amino acid cleaving enzyme	Homo sapiens	153-158
10505700-2	1999	KTS (lysine-threonine-serine) splice site mutations in WT1 intron 9 have been described in patients with Frasier syndrome, another rare syndrome defined by focal and segmental glomerulosclerosis (FSGS), XY pseudohermaphroditism, and frequent occurrence of gonadoblastoma.	Lysine	5-11	actinin alpha 4	Homo sapiens	196-200
10501225-1	1999	In alpha1, beta2, and gamma2 subunits of the gamma-aminobutyric acid A (GABA(A)) receptor, a conserved lysine residue occupies the position in the middle of the predicted extracellular loop between the transmembrane M2 and M3 regions.	Lysine	103-109	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	11-16
10485991-11	1999	We suggest that glucose decreases the Ca(2+)-ATPase activity by reacting with one essential Lys residue probably located in the vicinity of the catalytic site, which results in the full inactivation of the enzyme.	Lysine	92-95	dynein axonemal heavy chain 8	Homo sapiens	45-51
10485991-12	1999	Thus, Ca(2+)-ATPase activity measured in erythrocyte membranes or purified enzyme preparations preincubated with glucose depends on the remaining enzyme molecules in which the essential Lys residue stays unglycated.	Lysine	186-189	dynein axonemal heavy chain 8	Homo sapiens	13-19
10454588-4	1999	The ability to transduce signals is abolished by mutation of the invariant lysine (K334A) in subdomain II of H-Ryk.	Lysine	75-81	receptor like tyrosine kinase	Homo sapiens	111-114
10446158-3	1999	A modified SDF-1alpha (SDF-1 3/6) was generated by combined substitution of the basic cluster of residues Lys(24), His(25), and Lys(27) by Ser.	Lysine	106-109	C-X-C motif chemokine ligand 12	Homo sapiens	11-16
10444506-7	1999	MMP-2 proteolytic activity was increased by approximately eightfold in conditioned media taken from LV myocytes plated on poly-L-lysine compared with that of Matrigel.	Lysine	122-135	matrix metallopeptidase 2	Homo sapiens	0-5
10477183-11	1999	OP-Tc preference for amino acids in the P2 position was (Gly,Lys,Arg) &gt; Phe &gt; Leu &gt; Pro.	Lysine	61-64	opticin	Bos taurus	0-5
10393560-2	1999	Escherichia coli hemolysin A (HlyA), a toxic protein, is transcribed as a nontoxic protein and made toxic by internal acylation of two lysine residue epsilon-amino groups; HlyC catalyzes the acyl transfer from acyl-acyl carrier protein (ACP), the obligate acyl donor.	Lysine	135-141	hemolysin A	Escherichia coli	17-28
10397699-13	1999	Finally, chemical modification of lysine and arginine residues reduced the overall inhibition of tissue factor by TFPI.	Lysine	34-40	tissue factor pathway inhibitor	Homo sapiens	114-118
10364488-5	1999	The pair of lysine residues in this motif constitutes an essential element of the C-terminal NLS as mutation of this motif to AAQK directly affected the nuclear localization of either pp50 or beta-galactosidase fusion proteins containing the C-terminal portion of pp50.	Lysine	12-18	galactosidase beta 1	Homo sapiens	192-210
10383055-2	1999	Here, we show that, on a substratum of pleiotrophin formed from a 5 or 10 microg/ml solution, undifferentiated rat CG-4 line oligodendrocytes adopt a bipolar morphology and disperse over the substratum, as we have previously shown with poly-L-lysine (Rumsby et al.	Lysine	236-249	pleiotrophin	Rattus norvegicus	39-51
10383055-7	1999	On pleiotrophin substrata formed from coating solutions of 1 microg/ml and below, CG-4 line cells form aggregates and do not disperse, as is also the case with poly-L-lysine.	Lysine	160-173	pleiotrophin	Rattus norvegicus	3-15
10408336-6	1999	When amines were absent in the assay mixture as an external amino donor, lysine residue occurring in the peptide was an effective amino donor site for TGase.	Lysine	73-79	transglutaminase 1	Homo sapiens	151-156
10212234-7	1999	The lysine residue of the Sp100 protein, to which SUMO-1 is covalently linked, was mapped within and may therefore modulate the previously described HP1 protein-binding site.	Lysine	4-10	small ubiquitin like modifier 1	Homo sapiens	50-56
10191281-4	1999	For comparison, we have also examined peptides containing the reactive-centre loop sequences of human protein-C inhibitor (PCI) and rat kallikrein-binding protein, which were hydrolysed after Phe-Arg and Leu-Lys bonds, respectively.	Lysine	208-211	serpin family A member 5	Homo sapiens	102-121
10191281-4	1999	For comparison, we have also examined peptides containing the reactive-centre loop sequences of human protein-C inhibitor (PCI) and rat kallikrein-binding protein, which were hydrolysed after Phe-Arg and Leu-Lys bonds, respectively.	Lysine	208-211	serpin family A member 5	Homo sapiens	123-126
10191281-4	1999	For comparison, we have also examined peptides containing the reactive-centre loop sequences of human protein-C inhibitor (PCI) and rat kallikrein-binding protein, which were hydrolysed after Phe-Arg and Leu-Lys bonds, respectively.	Lysine	208-211	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	136-162
10198004-8	1999	Preferential cleavage of Caf1M by trypsin at Lys-119 confirmed surface exposure of this part of the FGL sequence in the isolated chaperone and periplasmic chaperone-subunit complex.	Lysine	45-48	F1 capsule protein	Yersinia pestis	25-30
10082538-5	1999	Mutation of lysine residue 798 in the DNA-dependent ATPase domain of BRG1 significantly reduced its ability to repress c-fos transcription.	Lysine	12-18	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	69-73
10089880-3	1999	We show that Mms2p forms a specific heteromeric complex with the UBC13-encoded E2 and is required for the Ubc13p-dependent assembly of polyubiquitin chains linked through lysine 63.	Lysine	171-177	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	13-18
10089880-3	1999	We show that Mms2p forms a specific heteromeric complex with the UBC13-encoded E2 and is required for the Ubc13p-dependent assembly of polyubiquitin chains linked through lysine 63.	Lysine	171-177	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	65-70
10089880-3	1999	We show that Mms2p forms a specific heteromeric complex with the UBC13-encoded E2 and is required for the Ubc13p-dependent assembly of polyubiquitin chains linked through lysine 63.	Lysine	171-177	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	106-112
10029542-3	1999	When myosin subfragment-1 (S1) binds to actin, these lysines may interact with the C-terminus of actin and be responsible for the isoform specific properties of myosin.	Lysine	53-60	myosin, heavy chain 15	Gallus gallus	5-11
10029542-3	1999	When myosin subfragment-1 (S1) binds to actin, these lysines may interact with the C-terminus of actin and be responsible for the isoform specific properties of myosin.	Lysine	53-60	myosin, heavy chain 15	Gallus gallus	161-167
10050771-3	1999	We sought to characterise the surface topology of the quaternary structure-dependent heparin-binding region of PDC-109 by comparing the arginine- and lysine-selective chemical modification patterns of the free and the heparin-bound protein.	Lysine	150-156	seminal plasma protein PDC-109	Bos taurus	111-118
9880483-3	1999	p300 specifically acetylates all sites of histones H2A and H2B known to be acetylated in bulk chromatin in vivo but preferentially acetylates lysines 14 and 18 of histone H3 and lysines 5 and 8 of histone H4.	Lysine	142-149	E1A binding protein p300	Homo sapiens	0-4
9880483-3	1999	p300 specifically acetylates all sites of histones H2A and H2B known to be acetylated in bulk chromatin in vivo but preferentially acetylates lysines 14 and 18 of histone H3 and lysines 5 and 8 of histone H4.	Lysine	178-185	E1A binding protein p300	Homo sapiens	0-4
9880483-4	1999	PCAF primarily acetylates lysine 14 of H3 but also less efficiently acetylates lysine 8 of H4.	Lysine	26-32	lysine acetyltransferase 2B	Homo sapiens	0-4
9880483-4	1999	PCAF primarily acetylates lysine 14 of H3 but also less efficiently acetylates lysine 8 of H4.	Lysine	79-85	lysine acetyltransferase 2B	Homo sapiens	0-4
9920509-7	1999	In competition experiments, LDL, apoE, polymers of lysine and arginine were all capable of preventing the lipase specific [125I]Lp(a) retention.	Lysine	51-57	lipoprotein(a)	Homo sapiens	128-133
34370992-1	2021	BACKGROUND: Epigenetic dysregulation participates in the initiation and progression of hepatocellular carcinoma (HCC).2 Bromodomain-containing protein 9 (BRD9)3 can identify acetylated lysine residues, contributing to several cancers.	Lysine	185-191	bromodomain containing 9	Homo sapiens	154-158
34518519-11	2021	Pyruvate dehydrogenase E1alpha (PDHE1alpha), which is the primary link between glycolysis and the TCA cycle, was hyper-acetylated at lysine 385 in TECs after TGF-beta1 stimulation and was regulated by SIRT3.	Lysine	133-139	transforming growth factor, beta 1	Mus musculus	158-167
34661079-2	2021	BET proteins contain two bromodomains, a common protein motif that selectively binds acetylated lysine on histones.	Lysine	96-102	delta/notch like EGF repeat containing	Homo sapiens	0-3
34369620-8	2021	Furthermore, p300 is a lysine acetyltransferase that catalyzes acetylation of histone and non-histone proteins in various cell types.	Lysine	23-29	E1A binding protein p300	Homo sapiens	13-17
34446611-2	2021	As a newly identified lysine specific methyltransferase targeting eEF1A at Lys-165, too little attention has been paid to the function of METTL21B.	Lysine	22-28	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	66-71
34446611-2	2021	As a newly identified lysine specific methyltransferase targeting eEF1A at Lys-165, too little attention has been paid to the function of METTL21B.	Lysine	75-78	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	66-71
34575025-3	2021	Several studies have shown that NSD1 controls gene expression by methylation of lysine 36 of histone 3 (H3K36me1/2) in a complex crosstalk with de novo DNA methylation.	Lysine	80-86	nuclear receptor binding SET domain protein 1	Homo sapiens	32-36
34445801-6	2021	In vitro assays and knockdown studies reveal that TRIM25 ubiquitinates DDX3X at lysine 55 (K55) and that TRIM25 and DDX3X cooperatively enhance IFNB1 induction following RIG-I activation, but the latter is independent of TRIM25"s catalytic activity.	Lysine	80-86	tripartite motif containing 25	Homo sapiens	50-56
34445801-6	2021	In vitro assays and knockdown studies reveal that TRIM25 ubiquitinates DDX3X at lysine 55 (K55) and that TRIM25 and DDX3X cooperatively enhance IFNB1 induction following RIG-I activation, but the latter is independent of TRIM25"s catalytic activity.	Lysine	80-86	DEAD-box helicase 3 X-linked	Homo sapiens	71-76
34237030-2	2021	We generated a mouse model with a mutation that disrupts sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues.	Lysine	72-78	thyroid hormone receptor beta	Mus musculus	120-124
34485285-6	2021	The ubiquitin (Ub)-proteasome pathway (UPP) dominates the majority of intracellular protein degradation by coupling Ub molecules to the lysine residues of protein substrate, which is subsequently recognized by the 26S proteasome for degradation.	Lysine	136-142	uridine phosphorylase 1	Homo sapiens	39-42
34132576-6	2021	Mutational and sequence analysis revealed conserved lysine/arginine residues at positions 49/50 and 91 of betaC1 proteins to be essential for their ATPase activity.	Lysine	52-58	dynein axonemal heavy chain 8	Homo sapiens	148-154
34132576-16	2021	The lysine/arginine residues conserved at positions 49 and 91 of betaC1 were found to be crucial for its ATPase function.	Lysine	4-10	dynein axonemal heavy chain 8	Homo sapiens	105-111
34321663-2	2021	Non-homologous end joining relies on 53BP1 binding directly to ubiquitinated lysine 15 on H2A-type histones (H2AK15ub)4,5 (which is an RNF168-dependent modification6), but how RNF168 promotes BRCA1 recruitment and function remains unclear.	Lysine	77-83	ring finger protein 168	Homo sapiens	135-141
34273561-6	2021	Mechanistically, SLM2 mediates intron retention, prevents exon exclusion, and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-, glutamate-, valine-, and lysine-rich (PEVK) domain and another part of the I-band region of titin.	Lysine	193-199	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	17-21
34244482-4	2021	Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by inducing transcription of the deacetylase sirtuin 3 (SIRT3).	Lysine	107-113	CREB regulated transcription coactivator 1	Mus musculus	63-69
34244482-4	2021	Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by inducing transcription of the deacetylase sirtuin 3 (SIRT3).	Lysine	107-113	glycine decarboxylase	Homo sapiens	87-91
34238351-6	2021	We identified three lysine residues (K469, K595 and K622) located on the surface of SAMHD1 as the major SUMOylation sites.	Lysine	20-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	84-90
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	lysine methyltransferase 2C	Homo sapiens	0-4
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	lysine methyltransferase 2C	Homo sapiens	5-10
34156443-5	2021	MLL3 and MLL4 form identical multi-protein complexes for modifying mono-methylation of histone H3 lysine 4 (H3K4) at enhancers, which together with the p300/CBP-mediated H3K27 acetylation can generate an active enhancer landscape for long-range target gene activation.	Lysine	98-104	lysine methyltransferase 2C	Homo sapiens	0-4
34258564-1	2021	Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability.	Lysine	54-60	euchromatic histone methyltransferase 1	Mus musculus	22-27
34258564-1	2021	Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability.	Lysine	54-60	euchromatic histone methyltransferase 1	Mus musculus	88-104
34258564-1	2021	Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability.	Lysine	54-60	euchromatic histone methyltransferase 1	Mus musculus	106-109
34201346-1	2021	The CREB-binding protein (CBP) and p300 are two paralogous lysine acetyltransferases (KATs) that were discovered in the 1980s-1990s.	Lysine	59-65	E1A binding protein p300	Homo sapiens	35-39
34199982-4	2021	Furthermore, the influence of the mitochondrial status on cytosolic NAD+ availability affecting the activity of cytosolic SIRT5 iso1 and iso4-in turn regulating cytosolic protein lysine succinylations-is presented.	Lysine	179-185	sirtuin 5	Homo sapiens	122-127
34123337-2	2021	The key advancement involved is to utilize the benzofuran moiety as the peptide salicylaldehyde ester surrogate, and Dap-Ser/Lys-Ser dipeptide as the hydroxyl amino functionality, which could be successfully introduced at the side chain of peptides enabling peptide ligation.	Lysine	125-129	death associated protein	Homo sapiens	117-120
35504076-6	2022	The umami structures in the six core umami peptides with the lowest binding energy were easy to connect with Ser, Glu, His, Gln, Arg and Lys residues in T1R3 through hydrogen bond and salt bridge.	Lysine	137-140	taste 1 receptor member 3	Homo sapiens	153-157
35136209-8	2022	Mechanistically, KDM6A promotes the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently leads to the inactivation of p65.	Lysine	89-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	157-160
35462054-1	2022	Lysine acetylation creates docking sites for epigenetic reader domains of BET bromodomain proteins that have emerged as principal regulators of linage specific gene transcription.	Lysine	0-6	delta/notch like EGF repeat containing	Homo sapiens	74-77
35524561-6	2022	This region is ubiquitinated at six lysines, where E3 ligases Siah1 and Siah2 bind and degrade these sequences.	Lysine	36-43	siah E3 ubiquitin protein ligase 1	Homo sapiens	62-67
35524561-6	2022	This region is ubiquitinated at six lysines, where E3 ligases Siah1 and Siah2 bind and degrade these sequences.	Lysine	36-43	siah E3 ubiquitin protein ligase 2	Homo sapiens	72-77
35500056-10	2022	l-Lactate can possibly be activated by acyl-coenzyme A (CoA) synthetases and transferred to lysine residues by histone acetyltransferases such as p300.	Lysine	92-98	E1A binding protein p300	Homo sapiens	146-150
35551465-5	2022	We find that the elevated expression of VEGFR2 is epigenetically regulated via intrinsic acetylation of histone 3 at lysine 27 by histone acetyltransferase P300.	Lysine	117-123	E1A binding protein p300	Homo sapiens	130-160
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	14-17	solute carrier family 7 member 2	Homo sapiens	80-86
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	14-17	solute carrier family 7 member 2	Homo sapiens	110-116
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	18-21	solute carrier family 7 member 2	Homo sapiens	80-86
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	18-21	solute carrier family 7 member 2	Homo sapiens	110-116
35543974-4	2022	Herein, to avoid denaturation of BMP-2 and enhance therapeutic action via localized delivery, a complex coacervate consisting of fucoidan, a marine-derived glycosaminoglycan, and poly-l-lysine (PLL) is fabricated.	Lysine	179-192	bone morphogenetic protein 2	Homo sapiens	33-38
35100351-8	2022	The lysine analog e-aminocaproic acid blocks plasmin-catalyzed bradykinin generation.	Lysine	4-10	plasminogen	Homo sapiens	45-52
35474067-5	2022	We now report that Cullin 3-KLHL20, a trans-Golgi network (TGN)-localized E3 ubiquitin ligase, polyubiquitinates SERINC5 at lysine 130 via K33/K48-linked ubiquitination.	Lysine	124-130	cullin 3	Homo sapiens	19-27
35428764-5	2022	Here, we reported that lysine demethylase 5B (KDM5B), a histone demethylase that specifically demethylates tri- and di-methylated H3 Lys-4 (H3K4), was upregulated in EwS and overexpressed KDM5B was correlated with poor outcomes of patients.	Lysine	133-136	lysine demethylase 5B	Homo sapiens	23-44
35428764-5	2022	Here, we reported that lysine demethylase 5B (KDM5B), a histone demethylase that specifically demethylates tri- and di-methylated H3 Lys-4 (H3K4), was upregulated in EwS and overexpressed KDM5B was correlated with poor outcomes of patients.	Lysine	133-136	lysine demethylase 5B	Homo sapiens	46-51
35428764-5	2022	Here, we reported that lysine demethylase 5B (KDM5B), a histone demethylase that specifically demethylates tri- and di-methylated H3 Lys-4 (H3K4), was upregulated in EwS and overexpressed KDM5B was correlated with poor outcomes of patients.	Lysine	133-136	EWS RNA binding protein 1	Homo sapiens	166-169
35428764-5	2022	Here, we reported that lysine demethylase 5B (KDM5B), a histone demethylase that specifically demethylates tri- and di-methylated H3 Lys-4 (H3K4), was upregulated in EwS and overexpressed KDM5B was correlated with poor outcomes of patients.	Lysine	133-136	lysine demethylase 5B	Homo sapiens	188-193
35419695-2	2022	Further studies have demonstrated that SETD3 may be able to methylase some other residues, including lysine and methionine, that substitute His73 in the beta-actin peptide.	Lysine	101-107	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	39-44
35418650-5	2022	Loss of Chd7 reduces the restriction of PPAR-gamma and then PPAR-gamma associates with trimethylated histone H3 at lysine 4 (H3K4me3), which subsequently activates the transcription of downstream adipogenic genes and disrupts the balance between osteogenic and adipogenic differentiation.	Lysine	115-121	chromodomain helicase DNA binding protein 7	Homo sapiens	8-12
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	Fibronectin type III domain-containing protein	Arabidopsis thaliana	142-146
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	Fibronectin type III domain-containing protein	Arabidopsis thaliana	170-174
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	Fibronectin type III domain-containing protein	Arabidopsis thaliana	175-179
35182940-0	2022	SMYD5 is a histone H3-specific methyltransferase mediating mono-methylation of histone H3 lysine 36 and 37.	Lysine	90-96	SMYD family member 5	Homo sapiens	0-5
35182940-1	2022	Although post-translational modifications (-PTMs) of some histone H3 lysine residues are well studied, the PTMs of histone H3 lysine 37 in mammalian cells remain largely unknown.	Lysine	69-75	parathymosin	Homo sapiens	44-48
35182940-1	2022	Although post-translational modifications (-PTMs) of some histone H3 lysine residues are well studied, the PTMs of histone H3 lysine 37 in mammalian cells remain largely unknown.	Lysine	126-132	parathymosin	Homo sapiens	107-111
35182940-2	2022	In this study, we provide evidence to show that SMYD family member 5 (SMYD5) is a histone H3-specfic methyltransferase that catalyzes mono-methylation of H3 lysine 36 and 37 (H3K36/K37me1) in vitro.	Lysine	157-163	SMYD family member 5	Homo sapiens	70-75
35210569-4	2022	ASH1L methylates Histone H3 on Lysine 36, which is proposed to result primarily in transcriptional activation.	Lysine	31-37	ASH1 like histone lysine methyltransferase	Homo sapiens	0-5
35346195-13	2022	Mechanistically, we demonstrated that BMI1 directly binds to the promoter region of SIK1 in a complex with RING1B to promote monoubiquitination of histone H2A at lysine 119 (H2AK119ub) and inhibit H3K4 trimethylation (H3K4me3), resulting in inhibition of SIK1 transcription.	Lysine	162-168	ring finger protein 2	Homo sapiens	107-113
35338347-9	2022	SUMOylation inhibition reduced DOT1L with decreased methylation of histone H3 lysine 79, to suppress IRF4 gene transcription.	Lysine	78-84	interferon regulatory factor 4	Homo sapiens	101-105
35044214-7	2022	Site-directed mutagenesis revealed that two lysine residues (K23 and K121) on VPS4A were important for VPS4A polyubiquitylation.	Lysine	44-50	vacuolar protein sorting 4 homolog A	Homo sapiens	78-83
35044214-7	2022	Site-directed mutagenesis revealed that two lysine residues (K23 and K121) on VPS4A were important for VPS4A polyubiquitylation.	Lysine	44-50	vacuolar protein sorting 4 homolog A	Homo sapiens	103-108
35317899-1	2022	Objective: SET8 is a member of the SET domain-containing family and the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20me1).	Lysine	134-140	lysine methyltransferase 5A	Homo sapiens	11-15
35296809-2	2022	Here, we show that histone lysine 4 dimethylation (H3K4me2), a histone mark linked to gene activation, is significantly decreased in the prefrontal cortex (PFC) of autistic human patients and mutant mice with the deficiency of top-ranking autism risk factor Shank3 or Cul3.	Lysine	27-33	cullin 3	Mus musculus	268-272
34990836-3	2022	Histone H3 lysine 36 (H3K36) methyltransferases, such as the SET-domain 2 protein (SETD2), have emerged as critical tumor suppressors.	Lysine	11-17	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	61-81
34990836-3	2022	Histone H3 lysine 36 (H3K36) methyltransferases, such as the SET-domain 2 protein (SETD2), have emerged as critical tumor suppressors.	Lysine	11-17	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	83-88
35143843-0	2022	A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments.	Lysine	2-8	bifunctional apoptosis regulator	Homo sapiens	31-34
35143843-8	2022	Taken together, our results support the hypothesis that the lysine-rich cluster in the N-BAR domain of ASAP1 is important for regulating actin filament organization.	Lysine	60-66	bifunctional apoptosis regulator	Homo sapiens	89-92
35046573-3	2022	Several mAbs (LY-CoV555, LY-CoV016, REGN10933, REGN10987 and CT-P59) completely lost neutralizing activity against B.1.1.529 virus in both Vero-TMPRSS2 and Vero-hACE2-TMPRSS2 cells, whereas others were reduced (COV2-2196 and COV2-2130 combination, ~12-fold decrease) or minimally affected (S309).	Lysine	14-16	angiotensin converting enzyme 2	Homo sapiens	161-166
35173149-9	2022	Overexpression of lncRNA ROR activated TESC by inhibiting the G9a recruitment on the promoter of TESC and histone H3-lysine 9me methylation.	Lysine	117-123	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	25-28
35197979-4	2022	We further demonstrated that BmTCTP could be modified by SUMOylation molecular BmSMT3 at the lysine 164 via the conjugating enzyme BmUBC9, and the stable SUMOylation of BmTCTP by expressing BmTCTP-BmSMT3 fusion protein exhibited strong antiviral activity, which confirmed that the SUMOylation of BmTCTP would contribute to its immune responses.	Lysine	93-99	translationally-controlled tumor protein homolog	Bombyx mori	29-35
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	interferon regulatory factor 3	Homo sapiens	39-43
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	interferon regulatory factor 3	Homo sapiens	59-63
35265200-10	2022	Additionally, HDAC5 diminished p65 acetylation at lysine-310, which is essential for the transcriptional activity of p65.	Lysine	50-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	31-34
35265200-10	2022	Additionally, HDAC5 diminished p65 acetylation at lysine-310, which is essential for the transcriptional activity of p65.	Lysine	50-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-120
35011726-9	2022	Moreover, we determine Nse4 (lysine K181) as the first known SMC5/6-associated Nse1 substrate.	Lysine	29-35	structural maintenance of chromosomes 5	Homo sapiens	61-67
35011726-9	2022	Moreover, we determine Nse4 (lysine K181) as the first known SMC5/6-associated Nse1 substrate.	Lysine	29-35	NSE1 homolog, SMC5-SMC6 complex component	Homo sapiens	79-83
10079520-0	1999	N-Cadherin expression and signaling in limb mesenchymal chondrogenesis: stimulation by poly-L-lysine.	Lysine	87-100	cadherin 2	Gallus gallus	0-10
9753439-8	1998	Both the mono- and pentaglutamate derivatives of 5-CHO-H4PteGlun were cross-linked to SHMT by a carbodiimide reaction to Lys-450 which resides in a stretch of Lys, His, and Arg residues.	Lysine	121-124	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	86-90
9753439-8	1998	Both the mono- and pentaglutamate derivatives of 5-CHO-H4PteGlun were cross-linked to SHMT by a carbodiimide reaction to Lys-450 which resides in a stretch of Lys, His, and Arg residues.	Lysine	159-162	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	86-90
9731073-1	1998	Hemoglobin E (HbE; alpha2beta226glu-lys), globally the commonest hemoglobin variant, is synthesized at a slightly reduced rate and has a homozygous phenotype similar to heterozygous beta thalassemia.	Lysine	36-39	hemoglobin subunit epsilon 1	Homo sapiens	14-17
9744860-4	1998	p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear localization signal.	Lysine	16-19	E1A binding protein p300	Homo sapiens	0-4
9744860-4	1998	p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear localization signal.	Lysine	87-90	lysine acetyltransferase 2B	Homo sapiens	71-75
19131641-4	2009	mTORC1 was dose- and time-dependently activated in murine bone marrow neutrophils cultured with the TLR4 ligand, LPS, or the TLR2 ligand, Pam(3) Cys-Ser-(Lys)(4) (PAM).	Lysine	154-157	peptidylglycine alpha-amidating monooxygenase	Mus musculus	163-166
9744270-4	1998	Glutamate and lysine residues that are highly conserved in LBDs of nuclear receptors form a "charge clamp" that contacts backbone atoms of the LXXLL helices of SRC-1.	Lysine	14-20	nuclear receptor coactivator 1	Homo sapiens	160-165
19694578-13	2009	111In-[DTPA(1), Lys(3), Tyr(4)]-BN is a potential agent for imaging GRPR-positive tumors in humans.	Lysine	16-19	gastrin releasing peptide receptor	Mus musculus	68-72
19493659-4	2009	We found that human, but not Drosophila, Pygo robustly interacts with a histone-H3 peptide methylated at lysine-4.	Lysine	105-111	pygopus	Drosophila melanogaster	41-45
9776208-3	1998	The activated enzyme suppresses fibrinolysis by removing carboxy terminal lysine residues from partially degraded fibrin, thereby preventing plasmin-mediated positive feedback in the fibrinolytic cascade.	Lysine	74-80	plasminogen	Homo sapiens	141-148
19423701-5	2009	Peptide array and mutagenesis studies localize the FAK binding interface to blades I-III of the RACK1 beta-propeller and specifically identify a set of basic and hydrophobic amino acids (Arg-47, Tyr-52, Arg-57, Arg-60, Phe-65, Lys-127, and Lys-130) as key determinants for association with FAK.	Lysine	227-230	protein tyrosine kinase 2	Homo sapiens	51-54
19002783-12	1998	These studies also identify specific lysines in NBD1 and NBD2 which are important for optimal MRP activity.	Lysine	37-44	ATP binding cassette subfamily C member 3	Homo sapiens	94-97
19423701-5	2009	Peptide array and mutagenesis studies localize the FAK binding interface to blades I-III of the RACK1 beta-propeller and specifically identify a set of basic and hydrophobic amino acids (Arg-47, Tyr-52, Arg-57, Arg-60, Phe-65, Lys-127, and Lys-130) as key determinants for association with FAK.	Lysine	240-243	protein tyrosine kinase 2	Homo sapiens	51-54
19494831-0	2009	Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.	Lysine	33-39	Polycomb	Drosophila melanogaster	59-67
9761476-0	1998	Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles.	Lysine	0-6	plasminogen	Homo sapiens	45-56
9761476-0	1998	Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles.	Lysine	79-85	plasminogen	Homo sapiens	45-56
19414603-4	2009	The histone H4 Lys 20 (H4K20) monomethyltransferase PR-Set7/Setd8 gene is upregulated by PPAR gamma during adipogenesis, and the knockdown of PR-Set7/Setd8 suppressed adipogenesis.	Lysine	15-18	lysine methyltransferase 5A	Homo sapiens	52-59
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	p21 (RAC1) activated kinase 1	Homo sapiens	136-140
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	cell division cycle 42	Homo sapiens	171-176
9777408-8	1998	First, certain mAbs raised against gC1q-R react moderately with intact Raji cells in suspension and this binding increases when the cells are first bound to poly-L-lysine coated surfaces and then fixed with glutaraldehyde.	Lysine	157-170	complement C1q binding protein	Homo sapiens	35-41
19414603-4	2009	The histone H4 Lys 20 (H4K20) monomethyltransferase PR-Set7/Setd8 gene is upregulated by PPAR gamma during adipogenesis, and the knockdown of PR-Set7/Setd8 suppressed adipogenesis.	Lysine	15-18	lysine methyltransferase 5A	Homo sapiens	60-65
19414603-4	2009	The histone H4 Lys 20 (H4K20) monomethyltransferase PR-Set7/Setd8 gene is upregulated by PPAR gamma during adipogenesis, and the knockdown of PR-Set7/Setd8 suppressed adipogenesis.	Lysine	15-18	lysine methyltransferase 5A	Homo sapiens	142-149
19414603-4	2009	The histone H4 Lys 20 (H4K20) monomethyltransferase PR-Set7/Setd8 gene is upregulated by PPAR gamma during adipogenesis, and the knockdown of PR-Set7/Setd8 suppressed adipogenesis.	Lysine	15-18	lysine methyltransferase 5A	Homo sapiens	150-155
19377055-7	2009	The incremental cost-effectiveness ratio (ICER) of IL2Ra compared to polyclonal induction was $14,803 per LYS and $25,928 per QALY.	Lysine	106-109	interleukin 2 receptor subunit alpha	Homo sapiens	51-56
9636150-2	1998	Four lysine residues in the N-terminal domain of PsaF, which have been postulated to form the positively charged face of a putative amphipathic alpha-helical structure were altered to K12P, K16Q, K23Q, and K30Q.	Lysine	5-11	uncharacterized protein	Chlamydomonas reinhardtii	49-53
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	cyclin D1	Homo sapiens	14-23
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	E1A binding protein p300	Homo sapiens	89-93
9645365-5	1998	Compared with rodent Ly-49 molecules, the Ly-49L sequence contains a premature stop codon and predicts a truncated protein that lacks the distal part of a C-terminal lectin domain.	Lysine	21-23	killer cell lectin like receptor A1, pseudogene	Homo sapiens	42-48
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	SET and MYND domain containing 3	Homo sapiens	91-94
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	cyclin G1	Homo sapiens	246-255
9593699-11	1998	The NMB receptor-specific antagonist D-Nal,Cys,Tyr,D-Trp,Lys,Val, Cys,Nal-NH2 inhibited hBRS-3 receptor activation in a competitive fashion (Ki = 0.5 microM).	Lysine	57-60	neuromedin B	Homo sapiens	4-7
9593699-11	1998	The NMB receptor-specific antagonist D-Nal,Cys,Tyr,D-Trp,Lys,Val, Cys,Nal-NH2 inhibited hBRS-3 receptor activation in a competitive fashion (Ki = 0.5 microM).	Lysine	57-60	bombesin receptor subtype 3	Homo sapiens	88-94
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	cyclin dependent kinase 2	Homo sapiens	260-264
19131354-10	2009	One (p.K301M) produced a lysine to methionine change in the third interactive SH3 domain (position 301) and resulted in the defective CD2-CD2AP interaction and clustering; the other (c.1573delAGA) caused the deletion of the glutamic acid in position 525 in the COOH-terminal region of binding with nephrin and was associated with down-modulation of CD2AP, podocin and nephrin glomerular expression.	Lysine	25-31	CD2 associated protein	Homo sapiens	349-354
9585533-2	1998	Indeed, cloning of rhesus monkey apo(a) has shown that a Trp72 --&gt; Arg mutation in the lysine-binding site (LBS) of KIV-10 leads to loss of lysine-binding properties of the rhesus Lp(a) particle.	Lysine	90-96	apolipoprotein(a)	Macaca mulatta	183-188
19463173-5	2009	RESULTS: Peptide 5nd (Tyr-Trp-c [Cys-Lys-Gly-Leu-Cys]-Lys-NH2, S-S) blocks the RGS4-Galphao interaction with an IC50 of 28 microM.	Lysine	37-40	regulator of G protein signaling 4	Homo sapiens	79-83
9578568-6	1998	Alanine scanning mutagenesis in the alpha-helix of finger 1 reveals that Lys-1 immediately preceding the helix is important for the recognition of the two guanine bases, but other putative key amino acids do not affect the DNA binding.	Lysine	73-76	Yip1 domain family member 1	Homo sapiens	51-59
19463173-5	2009	RESULTS: Peptide 5nd (Tyr-Trp-c [Cys-Lys-Gly-Leu-Cys]-Lys-NH2, S-S) blocks the RGS4-Galphao interaction with an IC50 of 28 microM.	Lysine	37-40	G protein subunit alpha o1	Homo sapiens	84-91
19416817-5	2009	We show that in barley (Hordeum vulgare), repression of HvVRN1 before vernalization is associated with high levels of histone 3 lysine 27 trimethylation (H3K27me3) at HvVRN1 chromatin.	Lysine	128-134	VERNALIZATION1	Hordeum vulgare	56-62
9560319-10	1998	Internalization studies on the Ala261--&gt;Lys mutant showed a marked decrease in receptor internalization compared with the wild type, indicating that coupling is necessary for effective receptor internalization in the GnRH receptor system.	Lysine	43-46	gonadotropin releasing hormone receptor	Homo sapiens	220-233
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	46-52	plasminogen	Homo sapiens	0-7
9590659-1	1998	The recent cloning of human cytidine deaminase (CDD) revealed two variants with a nonconservative amino acid deviation (Gln<-->Lys) at codon 27 within a region of structural homology to a core domain of bacterial CDDs.	Lysine	127-130	cytidine deaminase	Homo sapiens	28-46
9590659-1	1998	The recent cloning of human cytidine deaminase (CDD) revealed two variants with a nonconservative amino acid deviation (Gln<-->Lys) at codon 27 within a region of structural homology to a core domain of bacterial CDDs.	Lysine	127-130	cytidine deaminase	Homo sapiens	48-51
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	46-52	plasminogen	Homo sapiens	136-143
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	58-61	plasminogen	Homo sapiens	0-7
19240037-5	2009	Plasmin also cleaves recombinant NR2A(ATD) at lysine 317 (Lys(317)), thereby producing a approximately 40-kDa fragment, consistent with plasmin-induced NR2A cleavage fragments observed in rat brain membrane preparations.	Lysine	58-61	plasminogen	Homo sapiens	136-143
9518490-7	1998	Furthermore, in irs-20 we identified a mutation in DNA-PKcs that causes substitution of a lysine for a glutamic acid in the fourth residue from the C-terminus.	Lysine	90-96	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	51-59
19240037-6	2009	A homology model of the NR2A(ATD) predicts that Lys(317) is near the surface of the protein and is accessible to plasmin.	Lysine	48-51	plasminogen	Homo sapiens	113-120
9535830-12	1998	Several substitutions in the P6-P3 sequence were well tolerated; however, replacement of the Lys at the P6 position with Gly and replacement of the P3 Lys by an acidic residue led to markedly compromised cleavage by furin.	Lysine	93-96	furin, paired basic amino acid cleaving enzyme	Homo sapiens	216-221
9535830-12	1998	Several substitutions in the P6-P3 sequence were well tolerated; however, replacement of the Lys at the P6 position with Gly and replacement of the P3 Lys by an acidic residue led to markedly compromised cleavage by furin.	Lysine	151-154	furin, paired basic amino acid cleaving enzyme	Homo sapiens	216-221
9535830-15	1998	Substitution at the P1" position of Val for Ser in conjunction with Ala for Val at P2", as well as a single substitution of Lys for Val at P2", generated specific inhibitors of furin cleavage.	Lysine	124-127	furin, paired basic amino acid cleaving enzyme	Homo sapiens	177-182
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Lysine	35-38	plasminogen	Homo sapiens	13-20
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Lysine	35-38	plasminogen	Homo sapiens	84-91
19239905-4	2009	RESULTS: The Lys and Glu allele frequencies of apoL-I gene at Lys166Glu site in HTG and normal control groups were 0.857, 0.143 and 0.801, 0.199, respectively; The Ile and Met allele frequencies of the gene at Ile244Met site in HTG and the control groups were 0.868, 0.132 and 0.812, 0.188 respectively.	Lysine	13-16	apolipoprotein L1	Homo sapiens	47-53
19141540-0	2009	Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.	Lysine	146-152	clock circadian regulator	Homo sapiens	38-43
9584989-3	1998	Sodium dodecyl sulphate polyacrylamide gel-electrophoresis and microsequence analysis showed that the glyoxalase II is proteolyzed at the level of Arg 184 and Lys 230 and undergoes a third cleavage in a region located at the beginning of the supposed C-terminal domain.	Lysine	159-162	hydroxyacylglutathione hydrolase	Homo sapiens	102-115
19141540-6	2009	CLOCK and GR interacted with each other physically, and CLOCK suppressed binding of GR to its DNA recognition sequences by acetylating multiple lysine residues located in its hinge region.	Lysine	144-150	clock circadian regulator	Homo sapiens	0-5
9524222-7	1998	The COOH-terminus of this new isoform, which we designate beta 4, lacks a 22 amino acid lysine-rich sequence common to both the human red cell alpha- and beta-adducin subunits and homologous to a highly conserved region in MARCKS, a filamentous actin-cross linking protein regulated by protein kinase C and calcium/calmodulin.	Lysine	88-94	tubulin beta 3 class III	Homo sapiens	58-64
19141540-6	2009	CLOCK and GR interacted with each other physically, and CLOCK suppressed binding of GR to its DNA recognition sequences by acetylating multiple lysine residues located in its hinge region.	Lysine	144-150	clock circadian regulator	Homo sapiens	56-61
19270100-7	2009	By site-directed mutagenesis, we altered five lysine residues located at positions 343, 394, 420, 427, and 430 of enolase in A. hydrophila SSU; the mutated forms of enolase were hyperexpressed in Escherichia coli, and the proteins were purified.	Lysine	46-52	HMPREF1171_RS22025	Aeromonas hydrophila SSU	114-121
19270100-7	2009	By site-directed mutagenesis, we altered five lysine residues located at positions 343, 394, 420, 427, and 430 of enolase in A. hydrophila SSU; the mutated forms of enolase were hyperexpressed in Escherichia coli, and the proteins were purified.	Lysine	46-52	HMPREF1171_RS22025	Aeromonas hydrophila SSU	165-172
9531056-8	1998	The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches.	Lysine	4-10	lipoprotein(a)	Homo sapiens	28-33
9531056-8	1998	The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches.	Lysine	4-10	lipoprotein(a)	Homo sapiens	88-93
19368801-1	2009	Suppressor-of-zeste-12 (Su(z)12) is a core component of the Polycomb repressive complex 2 (PRC2), which has a methyltransferase activity directed towards lysine residues of histone 3.	Lysine	154-160	Polycomb	Drosophila melanogaster	60-68
9531056-8	1998	The lysine binding sites of Lp(a) contributed to the increased binding of PLA2-modified Lp(a) to the matrix, and the enhanced lysine binding functions of PLA2-modified Lp(a) was demonstrated by two independent approaches.	Lysine	4-10	lipoprotein(a)	Homo sapiens	88-93
19154201-3	2009	The chromatin modifier ARABIDOPSIS HOMOLOG OF TRITHORAX (ATX1) methylates lysine residue 4 on histone H3 (H3K4me), acting as an epigenetic mark on associated genes.	Lysine	74-80	homolog of anti-oxidant 1	Arabidopsis thaliana	57-61
9463363-0	1998	The PsaC subunit of photosystem I provides an essential lysine residue for fast electron transfer to ferredoxin.	Lysine	56-62	uncharacterized protein	Chlamydomonas reinhardtii	101-111
19262565-0	2009	Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.	Lysine	57-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-87
9490044-1	1998	Saccharomyces cerevisiae Lys7p was proposed to be the enzyme catalyzing the dehydratation of homocitrate to cis-homoaconitate, the second step of the lysine biosynthetic pathway.	Lysine	150-156	copper chaperone CCS1	Saccharomyces cerevisiae S288C	25-30
9490044-3	1998	Cells deleted for the LYS7 gene displayed, in addition to lysine auxotrophy, methionine auxotrophy, sensitivity to superoxide generating drugs and light irradiation, and diminution of calcineurin activity.	Lysine	58-64	copper chaperone CCS1	Saccharomyces cerevisiae S288C	22-26
19262565-5	2009	Mutational and mass spectrometric analyses reveal that RelA is monomethylated by Set9 at lysine residues 314 and 315 in vitro and in vivo.	Lysine	89-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-59
19280628-11	2009	Similarly, XRCC1 Arg/Gln together with XPC Lys/Lys was found to significantly increase the risk of HD (OR, 2.14; 95% CI, 1.09-4.23).	Lysine	43-46	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	39-42
9430722-5	1998	In contrast, mutation of the highly conserved lysine residues in the carboxyl terminus of HAH1 had no effect on copper trafficking to the secretory pathway but eliminated the antioxidant function of HAH1 in sod1 delta yeast.	Lysine	46-52	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	207-211
9427722-4	1998	We identified a novel Fc gamma RIIA genotype in a healthy individual homozygous for Fc gamma RIIA R/R131 in whom a C to A substitution at codon 127 changes glutamine (Q) to lysine (K) in one of the two Fc gamma RIIA genes.	Lysine	173-179	Fc gamma receptor IIa	Homo sapiens	22-35
9427722-4	1998	We identified a novel Fc gamma RIIA genotype in a healthy individual homozygous for Fc gamma RIIA R/R131 in whom a C to A substitution at codon 127 changes glutamine (Q) to lysine (K) in one of the two Fc gamma RIIA genes.	Lysine	173-179	Fc gamma receptor IIa	Homo sapiens	84-97
19280628-11	2009	Similarly, XRCC1 Arg/Gln together with XPC Lys/Lys was found to significantly increase the risk of HD (OR, 2.14; 95% CI, 1.09-4.23).	Lysine	47-50	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	39-42
9427722-4	1998	We identified a novel Fc gamma RIIA genotype in a healthy individual homozygous for Fc gamma RIIA R/R131 in whom a C to A substitution at codon 127 changes glutamine (Q) to lysine (K) in one of the two Fc gamma RIIA genes.	Lysine	173-179	Fc gamma receptor IIa	Homo sapiens	84-97
19299466-3	2009	Here, we show that RECQL4 specifically interacts with the histone acetyltransferase p300 (also known as p300 HAT), both in vivo and in vitro, and that p300 acetylates one or more of the lysine residues at positions 376, 380, 382, 385 and 386 of RECQL4.	Lysine	186-192	E1A binding protein p300	Homo sapiens	84-88
19299466-3	2009	Here, we show that RECQL4 specifically interacts with the histone acetyltransferase p300 (also known as p300 HAT), both in vivo and in vitro, and that p300 acetylates one or more of the lysine residues at positions 376, 380, 382, 385 and 386 of RECQL4.	Lysine	186-192	E1A binding protein p300	Homo sapiens	104-112
19299466-3	2009	Here, we show that RECQL4 specifically interacts with the histone acetyltransferase p300 (also known as p300 HAT), both in vivo and in vitro, and that p300 acetylates one or more of the lysine residues at positions 376, 380, 382, 385 and 386 of RECQL4.	Lysine	186-192	E1A binding protein p300	Homo sapiens	104-108
9537673-1	1998	Studies on ligand-receptor interaction of Angiotensin II (Ang II) receptor type 1 have shown that for peptidic ligands to bind this receptor they must interact via their C-terminal carboxylate group to the positively charged side chain of the Lysine residue 199 located in the fifth transmembrane domain of this receptor.	Lysine	243-249	angiotensin II receptor type 1 S homeolog	Xenopus laevis	42-81
19211567-2	2009	We previously showed that progesterone receptors (PR) have a single consensus psiKXE SUMO-conjugation motif centered at Lys-388 in the N-terminal domain of PR-B and a homologous site of PR-A.	Lysine	120-123	RB transcriptional corepressor 1	Homo sapiens	156-160
9598086-0	1998	Role of cysteine and lysine residues in human hypoxanthine-guanine phosphoribosyltransferase.	Lysine	21-27	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	46-92
19211567-5	2009	However, paradoxically, cellular overexpression of SUMO-1 increases PR transcriptional activity even if Lys-388 is mutated, suggesting that the receptors are activated indirectly by other SUMOylated proteins.	Lysine	104-107	small ubiquitin like modifier 1	Homo sapiens	51-57
19219073-4	2009	APE1 ubiquitination occurred specifically at Lys residues near the N-terminus, and was markedly enhanced by mouse double minute 2 (MDM2), the major intracellular p53 inhibitor.	Lysine	45-48	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
9923695-4	1998	According to these data apoC-I forms two helices, Val-4-Lys-30 and Leu-34-Lys-52, linked by an unstructured region Gln-31-Glu-33.	Lysine	56-59	apolipoprotein C1	Homo sapiens	24-30
9923695-4	1998	According to these data apoC-I forms two helices, Val-4-Lys-30 and Leu-34-Lys-52, linked by an unstructured region Gln-31-Glu-33.	Lysine	74-77	apolipoprotein C1	Homo sapiens	24-30
19251738-5	2009	The results indicate that CHD7 localizes to discrete locations along chromatin that are specific to each cell type, and that the cell-specific binding of CHD7 correlates with a subset of histone H3 methylated at lysine 4 (H3K4me).	Lysine	212-218	chromodomain helicase DNA binding protein 7	Homo sapiens	154-158
9504411-1	1998	We have evaluated the effect of lysine binding sites in kringle structures on the activation of plasminogen with plasmin and staphylokinase (SAK) complex and on the binding of plasminogen to SAK.	Lysine	32-38	plasminogen	Homo sapiens	96-103
19168731-8	2009	Mass spectrometric analyses of IL-4 and IL-5 showed that hydrolysis by RgpA-Kgp complexes was C terminal to Arg and Lys residues of the cytokines.	Lysine	116-119	interleukin 5	Homo sapiens	40-44
9504411-9	1998	Since EACA binds to plasminogen via lysine binding sites in the kringle structure, we propose that the lysine binding site in K1+2+3+4 domain plays a role in the activation of plasminogen by plasmin SAK complex, and in the binding of plasminogen to SAK.	Lysine	103-109	plasminogen	Homo sapiens	20-27
19188254-4	2009	Simultaneous deletion of SEM1 and UBP6 induces dramatic silencing defect accompanied by significantly increased level of ubiquitinated-histone H2B and markedly reduced levels of acetylated-lysine 14 and 23 on histone H3 at the telomeres.	Lysine	189-195	proteasome regulatory particle lid subunit SEM1	Saccharomyces cerevisiae S288C	25-29
9394010-5	1998	A comparison of the kinetics of fluorescent dye transfer showed Cx32, Cx26 and Cx45 to have progressively decreasing permeabilities to LY, but increasing permeabilities to DAPI.	Lysine	135-137	gap junction protein, beta 1	Rattus norvegicus	64-68
9394010-5	1998	A comparison of the kinetics of fluorescent dye transfer showed Cx32, Cx26 and Cx45 to have progressively decreasing permeabilities to LY, but increasing permeabilities to DAPI.	Lysine	135-137	gap junction protein, gamma 1	Rattus norvegicus	79-83
19200568-2	2009	We demonstrate that the nuclei of Tax-expressing cells, including HTLV-1 transformed T-lymphocytes, contain a pool of Tax molecules acetylated on lysine residue at amino acid position 346 by the transcriptional coactivator p300.	Lysine	146-152	E1A binding protein p300	Homo sapiens	223-227
9659916-4	1998	Fusion of ubiquitin in-frame to a receptor that lacks cytoplasmic tail lysines also promotes rapid receptor internalization, indicating that ubiquitin itself and not a specific type of linkage to the receptor acts as an internalization signal.	Lysine	71-78	ubiquitin	Saccharomyces cerevisiae S288C	10-19
19218452-1	2009	Force-distance measurements between supported lipid bilayers mimicking the cytoplasmic surface of myelin at various surface coverages of myelin basic protein (MBP) indicate that maximum adhesion and minimum cytoplasmic spacing occur when each negative lipid in the membrane can bind to a positive arginine or lysine group on MBP.	Lysine	309-315	myelin basic protein	Homo sapiens	137-157
9459510-4	1998	Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80.	Lysine	36-39	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	116-119
19218452-1	2009	Force-distance measurements between supported lipid bilayers mimicking the cytoplasmic surface of myelin at various surface coverages of myelin basic protein (MBP) indicate that maximum adhesion and minimum cytoplasmic spacing occur when each negative lipid in the membrane can bind to a positive arginine or lysine group on MBP.	Lysine	309-315	myelin basic protein	Homo sapiens	159-162
18983266-6	2009	Arg(333) and Lys(348) in the C-terminal tail of the beta2AR were identified as crucial determinants for Rab11 binding.	Lysine	13-16	RAB11A, member RAS oncogene family	Homo sapiens	104-109
9405039-5	1997	With these peptides, the recognition sequence for gamma-PAK has been shown to contain two basic amino acids in the -2 and -3 positions, as represented by (K/R)RXS, in which the -2 position is an arginine, the -3 position is an arginine or a lysine, and X can be an acidic, basic, or neutral amino acid.	Lysine	241-247	p21 (RAC1) activated kinase 2	Homo sapiens	50-59
9396730-4	1997	Accumulation of excess intracellular putrescine inhibits the formation of hypusine in vivo, a reaction that proceeds by the transfer of the butylamine moiety of spermidine to a lysine residue in eukaryotic initiation factor 5A (eIF-5A).	Lysine	177-183	eukaryotic translation initiation factor 5A	Rattus norvegicus	195-226
19217413-5	2009	We provide evidence that the phosphorylated residues contact lysine 39 and 35 in SUMO1 and SUMO2, respectively.	Lysine	61-67	small ubiquitin like modifier 1	Homo sapiens	81-86
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Lysine	21-24	thyrotropin releasing hormone	Homo sapiens	75-82
19021012-6	2009	The HDAC-3 activity was evaluated by ELISA using the fluorimetric HDAC lysyl substrate that comprises an acetylated lysine side chain.	Lysine	116-122	histone deacetylase 3	Homo sapiens	4-10
9409765-7	1997	Sequencing analysis revealed that the mutant HAC1 gene obtained from the ire15 mutant contained an AAA codon at position 50 instead of the AGA codon observed in the wild-type gene, resulting in the alteration of the aa from Arg to Lys.	Lysine	231-234	transcription factor HAC1	Saccharomyces cerevisiae S288C	45-49
9409765-7	1997	Sequencing analysis revealed that the mutant HAC1 gene obtained from the ire15 mutant contained an AAA codon at position 50 instead of the AGA codon observed in the wild-type gene, resulting in the alteration of the aa from Arg to Lys.	Lysine	231-234	transcription factor HAC1	Saccharomyces cerevisiae S288C	73-78
19036079-2	2009	A common polymorphism, A79C, in the gene encoding cytidine deaminase (CDA) changes a lysine residue to glutamine resulting in decreased enzyme activity.	Lysine	85-91	cytidine deaminase	Homo sapiens	50-68
9581570-3	1997	Treatment of APA with N-acetylimidazole results in a loss of enzymic activity; this is prevented by the competitive aminopeptidase inhibitor amastatin, suggesting the presence of an important tyrosine, lysine or cysteine residue at the active site of APA.	Lysine	202-208	glutamyl aminopeptidase	Mus musculus	13-16
19036079-2	2009	A common polymorphism, A79C, in the gene encoding cytidine deaminase (CDA) changes a lysine residue to glutamine resulting in decreased enzyme activity.	Lysine	85-91	cytidine deaminase	Homo sapiens	70-73
19068087-8	2009	In the analysis of the combined effects of alcohol consumption and genotype, significant impact of alcohol was seen for those subjects with ALDH2 Lys+ allele, ADH1B His/His, or ADH1C Arg/Arg (trend P = 0.077, 0.003, or 0.020, respectively), each of which is associated with a high concentration or rapid production of acetaldehyde.	Lysine	146-149	aldehyde dehydrogenase 2 family member	Homo sapiens	140-145
18981217-4	2009	Interestingly, a mutant cyclin G1 (8KR) in which all lysine residues in this region have been replaced with arginine can be both ubiquitinated in cells and stabilized by a proteasome inhibitor to a similar extent as wild-type cyclin G(1-137).	Lysine	53-59	cyclin G1	Homo sapiens	24-33
9427526-0	1997	Mutation of a conserved fifth transmembrane domain lysine residue (Lys215) attenuates ligand binding in the angiotensin II type 2 receptor.	Lysine	51-57	angiotensin II receptor type 2	Homo sapiens	108-138
9427526-1	1997	A fifth transmembrane domain lysine residue is conserved in both the type 1 (AT1) and type 2 (AT2) angiotensin II (AngII) receptors.	Lysine	29-35	angiotensin II receptor type 1	Homo sapiens	77-80
9427526-1	1997	A fifth transmembrane domain lysine residue is conserved in both the type 1 (AT1) and type 2 (AT2) angiotensin II (AngII) receptors.	Lysine	29-35	angiotensin II receptor type 2	Homo sapiens	94-97
9427526-2	1997	This lysine (Lys199) is believed to play a critical role in peptide binding for the AT1 receptor.	Lysine	5-11	angiotensin II receptor type 1	Homo sapiens	84-87
19010784-3	2009	We discovered that plasma carboxypeptidase N (CPN) and B (CPB or activated thrombin-activable fibrinolysis inhibitor, TAFIa) enhanced the bioactivity of 10-mer chemerin peptide NH(2)-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine (K).	Lysine	233-239	carboxypeptidase B2	Homo sapiens	75-116
9392417-4	1997	In the case of Lp[a], elastase digestion generates a miniLp[a] particle, which contains the apo[a] COOH-terminal domain able to bind to lysine, fibrinogen, fibronectin, and proteoglycans.	Lysine	136-142	lipoprotein(a)	Homo sapiens	15-19
19010785-7	2009	We found that a protein complex of Jmj had histone methyltransferase activity toward histone H3 lysine 9 (H3-K9).	Lysine	96-102	jumonji and AT-rich interaction domain containing 2	Homo sapiens	35-38
19017631-2	2009	Activation of RIG-I requires the ubiquitin ligase, TRIM25, which mediates lysine 63-linked polyubiquitination of the RIG-I N-terminal CARD-like region.	Lysine	74-80	tripartite motif containing 25	Homo sapiens	51-57
9353942-8	1997	A lysine residue that is a binding site for pyridoxal phosphate and an arginine residue that is a binding site for the alpha-carboxylate group of the substrate are conserved in ORF3.	Lysine	2-8	hypothetical protein	Escherichia coli	177-181
18939944-6	2009	The c-IAP1 UBA domain binds mono-ubiquitin and Lys(48)- and Lys(63)-linked polyubiquitin chains with low-micromolar affinities as determined by surface plasmon resonance or isothermal titration calorimetry.	Lysine	47-50	baculoviral IAP repeat containing 2	Homo sapiens	4-10
9359108-2	1997	The dimeric EMP1 was synthesized using a C-terminal lysine residue as a branch point.	Lysine	52-58	epithelial membrane protein 1	Mus musculus	12-16
18939944-6	2009	The c-IAP1 UBA domain binds mono-ubiquitin and Lys(48)- and Lys(63)-linked polyubiquitin chains with low-micromolar affinities as determined by surface plasmon resonance or isothermal titration calorimetry.	Lysine	60-63	baculoviral IAP repeat containing 2	Homo sapiens	4-10
19958198-4	2009	Further Hb analysis using automated capillary zone electrophoresis identified that the proband was in fact a compound heterozygote for Hb E [beta26(B8)Glu--&gt;Lys, GAG&gt;AAG] and another beta chain variant.	Lysine	160-163	hemoglobin subunit epsilon 1	Homo sapiens	135-139
9334180-4	1997	One mutant, pma1-alpha4, which has the single amino acid change Glu367 --&gt; Lys at a highly conserved site within the catalytic domain of the ATPase, was analyzed in detail to determine the mechanism of Na+ tolerance.	Lysine	78-81	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	12-16
9359434-0	1997	Characterization of chicken-liver glutathione S-transferase (GST) A1-1 and A2-2 isoenzymes and their site-directed mutants heterologously expressed in Escherichia coli: identification of Lys-15 and Ser-208 on cGSTA1-1 as residues interacting with ethacrynic acid.	Lysine	187-190	glutathione S-transferase alpha 3	Gallus gallus	34-59
18753126-3	2009	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Lysine	91-97	E1A binding protein p300	Homo sapiens	139-143
9351369-6	1997	Binding due to kringle interactions with lysine residues was calculated by subtracting from the total bound the amount of Lp(a) bound (approximately 10%) in the presence of 6-aminohexanoic acid.	Lysine	41-47	lipoprotein(a)	Homo sapiens	122-127
18753126-6	2009	p300 was able to perform autopropionylation on lysine residues in cells.	Lysine	47-53	E1A binding protein p300	Homo sapiens	0-4
19749310-3	2009	It is here reported that one 10-mer strand of alpha-lysine substituted peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in the presence of single-strand binding protein (SSB) via Watson-Crick rule.	Lysine	46-58	small RNA binding exonuclease protection factor La	Homo sapiens	165-194
9765841-3	1997	Plasmin-binding was both inhibitable and elutable by lysine or lysine analogs, and active plasmin bound to recombinant Plr was not neutralized by alpha 2-antiplasmin.	Lysine	53-59	plasminogen	Homo sapiens	0-7
9765841-3	1997	Plasmin-binding was both inhibitable and elutable by lysine or lysine analogs, and active plasmin bound to recombinant Plr was not neutralized by alpha 2-antiplasmin.	Lysine	63-69	plasminogen	Homo sapiens	0-7
9235940-0	1997	The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues.	Lysine	91-97	deoxyribonuclease 1	Bos taurus	30-37
9235940-5	1997	Phosphorylation of DNase I oligosaccharides decreased from 12.6% to 2.3% when Lys-50, Lys-124, and Arg-27 were mutated to alanines, indicating that these residues are required for the basal level of phosphorylation.	Lysine	78-81	deoxyribonuclease 1	Bos taurus	19-26
9235940-5	1997	Phosphorylation of DNase I oligosaccharides decreased from 12.6% to 2.3% when Lys-50, Lys-124, and Arg-27 were mutated to alanines, indicating that these residues are required for the basal level of phosphorylation.	Lysine	86-89	deoxyribonuclease 1	Bos taurus	19-26
19749310-3	2009	It is here reported that one 10-mer strand of alpha-lysine substituted peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in the presence of single-strand binding protein (SSB) via Watson-Crick rule.	Lysine	46-58	small RNA binding exonuclease protection factor La	Homo sapiens	196-199
19270745-11	2009	The PcG-associated histone modification, trimethylation of histone H3 lysine 27, is reduced in Asxl2(-/-) heart.	Lysine	70-76	Polycomb	Drosophila melanogaster	4-7
19436740-5	2009	Here, we show that DRIL1 is sumoylated both in vitro and in vivo at lysine 398.	Lysine	68-74	AT rich interactive domain 3A (BRIGHT-like)	Mus musculus	19-24
9263881-4	1997	Docking with the model of the Kv1.3 channel started by location of Lys-27 side chain into the central axis of the pore, followed by energy minimization.	Lysine	67-70	potassium voltage-gated channel subfamily A member 3	Homo sapiens	30-35
18957409-1	2008	We show that the Saccharomyces cerevisiae ribosomal protein Rpl42ab (the identical product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.	Lysine	144-147	ribosomal 60S subunit protein L42B	Saccharomyces cerevisiae S288C	109-115
9210374-7	1997	Stimulation of CED-3-dependent apoptosis by CED-4 was accompanied by accelerated processing of CED-3, which was dependent on the presence of a wild-type CED-3 prodomain and a conserved lysine residue within a putative ATP/GTP-binding motif of CED-4.	Lysine	185-191	Cell death protein 4	Caenorhabditis elegans	44-49
18957409-1	2008	We show that the Saccharomyces cerevisiae ribosomal protein Rpl42ab (the identical product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.	Lysine	155-158	ribosomal 60S subunit protein L42B	Saccharomyces cerevisiae S288C	109-115
18845537-3	2008	This latter reaction is catalyzed by holocarboxylase synthetase (HCS) via synthesis of 5"-biotinyl-AMP (B-AMP) from biotin and ATP, followed by transfer of the biotin to a specific lysine residue of the apocarboxylase substrate.	Lysine	181-187	holocarboxylase synthetase	Homo sapiens	37-63
9215742-5	1997	This protein, GAL4/Inv, together with poly-L-lysine, formed complexes with a chloramphenicol acetyltransferase (CAT) reporter plasmid that contains eight repeats of the GAL4 consensus recognition sequence.	Lysine	38-51	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	14-18
9215742-5	1997	This protein, GAL4/Inv, together with poly-L-lysine, formed complexes with a chloramphenicol acetyltransferase (CAT) reporter plasmid that contains eight repeats of the GAL4 consensus recognition sequence.	Lysine	38-51	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	169-173
9207218-5	1997	Space-filling CPK models of a proposed beta-helical conformation of the peptide, in which the leucine side chains form a hydrophobic core and the hydrophilic lysine and glutamate side chains extend outwards from the helix, had a diameter consistent with the observed 2-nm diameter of the fibrils.	Lysine	158-164	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	14-17
18845537-3	2008	This latter reaction is catalyzed by holocarboxylase synthetase (HCS) via synthesis of 5"-biotinyl-AMP (B-AMP) from biotin and ATP, followed by transfer of the biotin to a specific lysine residue of the apocarboxylase substrate.	Lysine	181-187	holocarboxylase synthetase	Homo sapiens	65-68
18852282-1	2008	The ink of sea hares (Aplysia californica) contains escapin, an L-amino acid oxidase that metabolizes L-lysine, thereby producing a mixture that kills microbes and deters attacking predators.	Lysine	102-110	L-amino-acid oxidase	Aplysia californica	52-59
9202142-3	1997	The heparin binding activity of PF4 has been introduced into an unrelated leucine zipper sequence only by virtue of incorporating four lysines of PF4.	Lysine	135-142	platelet factor 4	Homo sapiens	32-35
9202142-5	1997	These results strongly suggest that the lysine residues play an important role in the binding of PF4 to heparin.	Lysine	40-46	platelet factor 4	Homo sapiens	97-100
18953286-2	2008	Here, we show that the manganese transporter Smf1 is endocytosed when cells are exposed to cadmium ions, that this endocytosis depends on Rsp5-dependent ubiquitination of specific lysines and that it also requires phosphorylation at nearby sites.	Lysine	180-187	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	45-49
9191969-3	1997	When compared to reference inhibitors, in vitro HLE inhibitory potency was maintained (10-100 nM) both with compounds containing the antioxidant moiety at the end of the N-terminal side chain and with compounds in which the N-terminal valine of the tripeptidic sequence had been replaced by a epsilon-substituted lysine.	Lysine	313-319	elastase, neutrophil expressed	Homo sapiens	48-51
19074853-5	2008	A lysine-less cyclin D1 species was resistant to these effects.	Lysine	2-8	cyclin D1	Homo sapiens	14-23
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Lysine	129-132	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
9261893-3	1997	Plasmin-induced platelet aggregation was inhibited by serine protease inhibitors, aprotinin and bdellin, and a lysine binding site inhibitor, epsilon-aminocaproic acid (EACA).	Lysine	111-117	plasminogen	Homo sapiens	0-7
9261893-9	1997	The binding of plasmin to platelets was suppressed by aprotinin and EACA, furthermore indicating that protease catalytic sites and lysine binding regions are involved in interaction of plasmin to platelet.	Lysine	131-137	plasminogen	Homo sapiens	15-22
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	interferon alpha 2	Homo sapiens	35-45
9261893-9	1997	The binding of plasmin to platelets was suppressed by aprotinin and EACA, furthermore indicating that protease catalytic sites and lysine binding regions are involved in interaction of plasmin to platelet.	Lysine	131-137	plasminogen	Homo sapiens	185-192
9115288-8	1997	The addition of two extra lysine residues at the carboxyl terminus or the conversion of the glutamic acids at positions 170 and 171 to lysines also prevented SSAT degradation by the proteasome.	Lysine	26-32	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	158-162
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	interferon alpha 2	Homo sapiens	54-64
9115288-8	1997	The addition of two extra lysine residues at the carboxyl terminus or the conversion of the glutamic acids at positions 170 and 171 to lysines also prevented SSAT degradation by the proteasome.	Lysine	135-142	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	158-162
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	interferon alpha 2	Homo sapiens	54-64
9169591-6	1997	With the aid of protein engineering, a modified pro-urokinase has been prepared in which the activation sequence normally recognized by plasmin (Pro-Arg-Phe-Lys upward arrowIle-Ile-Gly-Gly) has been replaced by a sequence expected to be recognized and hydrolysed by many MMPs (Arg-Pro-Leu-Gly upward arrowIle-Ile-Gly-Gly).	Lysine	157-160	plasminogen	Homo sapiens	136-143
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	interferon alpha 2	Homo sapiens	54-64
18782761-3	2008	Here we show that mouse KLF5 is SUMOylated at lysine residues 151 and 202.	Lysine	46-52	Kruppel-like factor 5	Mus musculus	24-28
18782761-4	2008	Mutation of these two lysines or two conserved nearby glutamates results in the loss of SUMOylation and increased cytoplasmic distribution of KLF5, suggesting that SUMOylation enhances nuclear localization of KLF5.	Lysine	22-29	Kruppel like factor 5	Homo sapiens	142-146
18782761-4	2008	Mutation of these two lysines or two conserved nearby glutamates results in the loss of SUMOylation and increased cytoplasmic distribution of KLF5, suggesting that SUMOylation enhances nuclear localization of KLF5.	Lysine	22-29	Kruppel like factor 5	Homo sapiens	209-213
18849969-6	2008	In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1).	Lysine	68-71	CREB regulated transcription coactivator 2	Mus musculus	32-37
9165092-1	1997	Lysine was substituted for a conserved arginine at position 199 of the schistosomal hypoxanthine phosphoribosyltransferase (HPRT).	Lysine	0-6	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	84-122
9165092-1	1997	Lysine was substituted for a conserved arginine at position 199 of the schistosomal hypoxanthine phosphoribosyltransferase (HPRT).	Lysine	0-6	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	124-128
18849969-6	2008	In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1).	Lysine	68-71	CREB regulated transcription coactivator 2	Mus musculus	102-107
18977325-3	2008	ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias.	Lysine	43-49	immunoglobulin kappa variable 4-80	Mus musculus	107-110
9204520-1	1997	The authors have recently reported on the design of a protein (MB-1) enriched in methionine, threonine, lysine, and leucine.	Lysine	104-110	CD79a molecule	Bos taurus	63-67
18923077-3	2008	We identified a critical lysine residue in histone H4 that is needed for interaction with Set2 and proper H3 K36 di- and trimethylation.	Lysine	25-31	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	90-94
9130696-1	1997	Activation of furin requires autoproteolytic cleavage of its 83-amino acid propeptide at the consensus furin site, Arg-Thr-Lys-Arg107/.	Lysine	123-126	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
9130696-1	1997	Activation of furin requires autoproteolytic cleavage of its 83-amino acid propeptide at the consensus furin site, Arg-Thr-Lys-Arg107/.	Lysine	123-126	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
9130696-8	1997	Co-immunoprecipitation studies coupled with analysis by mass spectrometry show that release of the propeptide at acidic pH, and hence activation of furin, requires a second cleavage within the autoinhibitory domain at a site containing a P6 arginine (-Arg70-Gly-Val-Thr-Lys-Arg75/-).	Lysine	270-273	furin, paired basic amino acid cleaving enzyme	Homo sapiens	148-153
18655826-5	2008	We then delineated signal transduction from Erk2-mediated phosphorylation of RIP140 that enhanced its recruiting p300 for subsequent lysine acetylation, and demonstrated the kinetics of activation of this signal transduction pathway in differentiating adipocytes.	Lysine	133-139	nuclear receptor interacting protein 1	Homo sapiens	77-83
18655826-5	2008	We then delineated signal transduction from Erk2-mediated phosphorylation of RIP140 that enhanced its recruiting p300 for subsequent lysine acetylation, and demonstrated the kinetics of activation of this signal transduction pathway in differentiating adipocytes.	Lysine	133-139	E1A binding protein p300	Homo sapiens	113-117
9135131-5	1997	We have mutated (independently or together) two lysine residues in the Walker A (W(A)) motifs of the first (K719A) and second (K1384M) nucleotide-binding domains (NBDs) of SUR1.	Lysine	48-54	ATP binding cassette subfamily C member 8	Homo sapiens	172-176
18655826-7	2008	These results demonstrate the signal transduction pathway, initiated from Erk2 activation for specific threonine phosphorylation, followed by p300 recruitment for lysine acetylation, which ultimately enhances the gene-repressive activity of RIP140 and its functional role in fat accumulation in differentiated adipocytes.	Lysine	163-169	E1A binding protein p300	Homo sapiens	142-146
18655826-7	2008	These results demonstrate the signal transduction pathway, initiated from Erk2 activation for specific threonine phosphorylation, followed by p300 recruitment for lysine acetylation, which ultimately enhances the gene-repressive activity of RIP140 and its functional role in fat accumulation in differentiated adipocytes.	Lysine	163-169	nuclear receptor interacting protein 1	Homo sapiens	241-247
18832068-1	2008	We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere.	Lysine	124-127	histone deacetylase 3	Homo sapiens	29-50
9062131-5	1997	N-Terminal sequencing revealed that both the Mr 147,000 and 107,000 polypeptides had the same N-terminal sequence resulting from cleavage of aminopeptidase A by trypsin at the Lys-42-Asp-43 bond just outside the membrane-spanning hydrophobic region.	Lysine	176-179	glutamyl aminopeptidase	Homo sapiens	141-157
18832068-1	2008	We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere.	Lysine	124-127	histone deacetylase 3	Homo sapiens	52-57
18647749-0	2008	G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.	Lysine	13-19	CCAAT enhancer binding protein beta	Homo sapiens	55-90
9095553-4	1997	Replacement of lysine with alanine at the pyridoxal phosphate (PLP) binding site of the ACC deaminase caused a lower content of PLP and loss of detectable activity of ACC deamination.	Lysine	15-21	pyridoxal phosphatase	Homo sapiens	63-66
9095553-4	1997	Replacement of lysine with alanine at the pyridoxal phosphate (PLP) binding site of the ACC deaminase caused a lower content of PLP and loss of detectable activity of ACC deamination.	Lysine	15-21	pyridoxal phosphatase	Homo sapiens	128-131
18647749-5	2008	A conserved lysine residue in the C/EBPbeta TAD served as a substrate for G9a-mediated methylation.	Lysine	12-18	CCAAT enhancer binding protein beta	Homo sapiens	34-43
18647749-7	2008	A C/EBPbeta TAD mutant that contained a lysine-to-alanine exchange was resistant to G9a-mediated inhibition.	Lysine	40-46	CCAAT enhancer binding protein beta	Homo sapiens	2-11
18650421-9	2008	Microarray profiling revealed that, in TNF-alpha-stimulated monocytes, the induction of 25% NF-kappaB downstream genes, including the histone H3-lysine 27 demethylase JMJD3, was attenuated by SET7/9 depletion.	Lysine	145-151	SET domain containing (lysine methyltransferase) 7	Mus musculus	192-198
18805092-2	2008	Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates CRL ubiquitination activity and prevents binding of the inhibitor CAND1.	Lysine	95-101	NEDD8 ubiquitin like modifier	Homo sapiens	50-55
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Lysine	67-73	interferon alpha 2	Homo sapiens	17-27
18805092-2	2008	Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates CRL ubiquitination activity and prevents binding of the inhibitor CAND1.	Lysine	95-101	cullin associated and neddylation dissociated 1	Homo sapiens	179-184
18681895-6	2008	A lysine residue at amino acid 634 of BCL11A is SUMOylated but not required for the SUMO1 recruitment.	Lysine	2-8	BAF chromatin remodeling complex subunit BCL11A	Homo sapiens	38-44
9078247-0	1997	Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3 alpha-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis.	Lysine	35-38	aldo-keto reductase family 1 member C3	Homo sapiens	71-107
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	lysine methyltransferase 5A	Homo sapiens	74-79
9128099-5	1997	The S2 binding subsite of POP can accommodate amino acid residues with a bulky side group, while it prefers a positively charged group (free Lys) instead of a negatively charged one (free Glu).	Lysine	141-144	prolyl endopeptidase	Homo sapiens	26-29
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	lysine methyltransferase 5A	Homo sapiens	81-85
18614799-4	2008	27nt RNA duplex induced hyperacetylation in H3 (lysine8, 12, and 23) and H4 (lysine 9 and 12) at the 27nt repeat element, which then interacted with nuclear actin, histone deacetylase 3 (HDAC3), and NonO proteins.	Lysine	48-54	histone deacetylase 3	Homo sapiens	164-185
8960907-6	1996	N-terminal sequencing of purified human beta 2m produced in fungi (f beta 2m) revealed that 28% of the purified protein was of proper sequence and 61% of the protein had an additional serine and lysine residue derived from the C-terminus of the fungal leader.	Lysine	195-201	beta-2 microglobulin	Mus musculus	40-47
18614799-4	2008	27nt RNA duplex induced hyperacetylation in H3 (lysine8, 12, and 23) and H4 (lysine 9 and 12) at the 27nt repeat element, which then interacted with nuclear actin, histone deacetylase 3 (HDAC3), and NonO proteins.	Lysine	48-54	histone deacetylase 3	Homo sapiens	187-192
18614799-4	2008	27nt RNA duplex induced hyperacetylation in H3 (lysine8, 12, and 23) and H4 (lysine 9 and 12) at the 27nt repeat element, which then interacted with nuclear actin, histone deacetylase 3 (HDAC3), and NonO proteins.	Lysine	48-54	non-POU domain containing octamer binding	Homo sapiens	199-203
18719106-6	2008	HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-linked polyubiquitination of PCNA.	Lysine	77-83	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	116-120
8951564-17	1996	By site-directed mutagenesis of amino acids of this region, we were able to show that 6 residues, Lys-Asp-Asp-Lys-Pro-Val402, of SERCA 2 are functionally important for the interaction.	Lysine	98-101	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	129-136
8910391-7	1996	The binding constant for Glu-Pg was estimated as 7.4 microM and for Lys-Pg as 0.28 microM; for active-site blocked plasmin the binding constant was less than 0.05 microM.	Lysine	68-71	plasminogen	Homo sapiens	115-122
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Lysine	57-60	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	19-23
8887660-2	1996	Multiple copies of ATX2 were found to reverse the aerobic auxotrophies of sod1(delta) mutants for lysine and methionine and also to enhance the resistance of these yeast strains to paraquat and atmospheric levels of oxygen.	Lysine	98-104	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	74-78
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Lysine	57-60	kringle containing transmembrane protein 1	Homo sapiens	110-116
18502762-5	2008	We were surprised to find that the Dkk1 mutants carrying a mutation at Arg(197), Ser(198), or Lys(232), the key Kremen-binding residues, could antagonize Wnt signaling as well as the wild-type Dkk1.	Lysine	94-97	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	35-39
18502762-5	2008	We were surprised to find that the Dkk1 mutants carrying a mutation at Arg(197), Ser(198), or Lys(232), the key Kremen-binding residues, could antagonize Wnt signaling as well as the wild-type Dkk1.	Lysine	94-97	kringle containing transmembrane protein 1	Homo sapiens	112-118
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Lysine	57-60	CDC like kinase 1	Homo sapiens	14-17
18701507-0	2008	Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.	Lysine	34-40	lysine acetyltransferase 8	Homo sapiens	8-12
18550644-1	2008	WNK1 kinase belongs to a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine.	Lysine	112-118	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
8841413-4	1996	Substitution of the His or Lys residues with Ala in the IF1-(42-58)-peptide decreased the inhibition of ATP hydrolysis.	Lysine	27-30	ATP synthase inhibitory factor subunit 1	Bos taurus	56-59
18625006-10	2008	Bat2p was found to be less specific and used proline, lysine, tyrosine and glutamate as amino donors in addition to the branched chain amino acids.	Lysine	54-60	branched-chain-amino-acid transaminase BAT2	Saccharomyces cerevisiae S288C	0-5
8718881-8	1996	Much of the ATP-dependent degradation of 125I-alpha-globin and, to a lesser degree, 125I-lysozyme may occur through alternative structures where ubiquitin monomers or short oligomers are ligated to one or more substrate lysines.	Lysine	220-227	hemoglobin subunit alpha 2	Homo sapiens	46-58
18563844-5	2008	We have also demonstrated that several chemical xenobiotics, chosen based on quantitative structural activity relationship analysis and rigorous epitope analysis, when coupled to the lysine residue that normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better to PBC sera than native autoantigen.	Lysine	183-189	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	246-252
8864949-3	1996	Lp[a] was further purified using a lysine-Sepharose affinity column and Lp[a]- obtained by incubating Lp[a] with dithiothreitol.	Lysine	35-41	lipoprotein(a)	Homo sapiens	0-4
2553728-11	1989	These results show that the carboxyl-terminal amino acid residues are either directly or indirectly implicated in the three catalytic functions of the human bisphosphoglycerate mutase, and that the two terminal lysine residues are not essential for the major part of the enzymatic mechanism of the enzyme.	Lysine	211-217	bisphosphoglycerate mutase	Homo sapiens	157-183
8756332-3	1996	The major determinant for the switch in specificity is the opposite charge of residue 31--Lys in Rap, Glu in Ras--which creates a favourable complementary interface for the Ras-Raf interaction.	Lysine	90-93	zinc fingers and homeoboxes 2	Homo sapiens	177-180
18455220-8	2008	EDN release was also induced by lysine-coated beads with cytokines (67.1 ng/100 microL) and blocked by heparin.	Lysine	32-38	ribonuclease A family member 2	Homo sapiens	0-3
2677144-0	1989	Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein.	Lysine	110-113	myosin heavy chain 14	Homo sapiens	76-82
2677144-0	1989	Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein.	Lysine	118-121	myosin heavy chain 14	Homo sapiens	76-82
2677144-6	1989	Therefore, the majority of mouse and human myosin crossreactive antibodies recognized an epitope within the 14 residue carboxy terminus of PepM5 which appeared to involve the GLN-LYS-SER-LYS-GLN sequence.	Lysine	179-182	myosin heavy chain 14	Homo sapiens	43-49
2677144-6	1989	Therefore, the majority of mouse and human myosin crossreactive antibodies recognized an epitope within the 14 residue carboxy terminus of PepM5 which appeared to involve the GLN-LYS-SER-LYS-GLN sequence.	Lysine	187-190	myosin heavy chain 14	Homo sapiens	43-49
18499670-6	2008	The activity of FP6 also was blocked by mutating Lys(1370) and Lys(1374), which precludes LRP-1 binding.	Lysine	49-52	LDL receptor related protein 1	Rattus norvegicus	90-95
18480059-2	2008	In this report we demonstrate that one of these enzymes, PR-Set7, and its corresponding histone modification, the monomethylation of histone H4 lysine 20 (H4K20), display a distinct cell cycle profile in mammalian cells: low at G1, increased during late S phase and G2, and maximal from prometaphase to anaphase.	Lysine	144-150	lysine methyltransferase 5A	Homo sapiens	57-64
2509779-0	1989	Lysine-specific cleavage of beta 2-microglobulin in amyloid deposits associated with hemodialysis.	Lysine	0-6	beta-2-microglobulin	Homo sapiens	28-48
2547586-7	1989	In the presence of 1 microM poly-L-lysine insulin stimulates pp195 phosphorylation in a dose-dependent manner (k0.5, approximately 5 x 10(-10) M; maximum approximately 10(-8) M insulin); pp195 phosphorylation by insulin-like growth factor-I requires about 100-fold higher doses.	Lysine	28-41	insulin-like growth factor 1	Rattus norvegicus	212-240
8844414-4	1996	We present here a procedure for Lp(a) purification based on sequential elutions after lysine-Sepharose affinity chromatography.	Lysine	86-92	lipoprotein(a)	Homo sapiens	32-36
8844414-5	1996	We were able to identify four distinct subspecies of Lp(a) showing different affinity to epsilon-amino groups of lysine-Sepharose, simply by modifying molarity and pH of the eluents; the fraction obtained in highly purified state represented the major form and could be eluted with 0.5 M sodium phosphate buffer (pH 4.4).	Lysine	113-119	lipoprotein(a)	Homo sapiens	53-58
18521183-3	2008	We report here that HSN2 is a nervous system-specific exon of the with-no-lysine(K)-1 (WNK1) gene.	Lysine	74-80	WNK lysine deficient protein kinase 1	Mus musculus	20-24
8679640-2	1996	The ethylation interference analyses of Spl(R565S) and Spl(K595S) mutants demonstrate that arginine at 565 position and lysine at 595 position interact with the phosphate between G(3) and G(4) and with the phosphate between G(9) and G(10) in GC-box DNA, respectively.	Lysine	120-126	sphingosine-1-phosphate lyase 1	Homo sapiens	40-43
8679640-2	1996	The ethylation interference analyses of Spl(R565S) and Spl(K595S) mutants demonstrate that arginine at 565 position and lysine at 595 position interact with the phosphate between G(3) and G(4) and with the phosphate between G(9) and G(10) in GC-box DNA, respectively.	Lysine	120-126	sphingosine-1-phosphate lyase 1	Homo sapiens	55-58
8679640-3	1996	On the basis of the experimental results for Spl(K535G), Sp1(537-623), and Sp1(530-623), lysine and glutamine at 535 and 536 positions have been clarified to be in contacts with phosphate between G(7) and G(8) and with phosphate outside GC-box, respectively.	Lysine	89-95	sphingosine-1-phosphate lyase 1	Homo sapiens	45-50
2506440-0	1989	A lysine substitution in the ATP-binding site of eucaryotic initiation factor 4A abrogates nucleotide-binding activity.	Lysine	2-8	eukaryotic translation initiation factor 4A2	Homo sapiens	49-80
2506440-5	1989	Mutation of the lysine residue (but not of the glycine residue) resulted in the loss of [alpha-32P]dATP cross-linking to eIF-4A, suggesting that the lysine is an important determinant in ATP binding to eIF-4A.	Lysine	16-22	eukaryotic translation initiation factor 4A2	Homo sapiens	121-127
2506440-5	1989	Mutation of the lysine residue (but not of the glycine residue) resulted in the loss of [alpha-32P]dATP cross-linking to eIF-4A, suggesting that the lysine is an important determinant in ATP binding to eIF-4A.	Lysine	16-22	eukaryotic translation initiation factor 4A2	Homo sapiens	202-208
18521183-3	2008	We report here that HSN2 is a nervous system-specific exon of the with-no-lysine(K)-1 (WNK1) gene.	Lysine	74-80	WNK lysine deficient protein kinase 1	Mus musculus	87-91
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Lysine	108-114	E1A binding protein p300	Homo sapiens	38-42
2499329-2	1989	Glucose-6-phosphate dehydrogenase from the yeast Pichia jadinii has a reactive lysine residue in a segment of amino acid sequence Ile-Asp-His-Tyr-Leu-Gly-Lys*-Glu-Met-Val-Lys.	Lysine	79-85	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
8666250-6	1996	The derived aa sequence of UGPase contains three putative N-glycosylation sites and has a highly conserved positioning of five Lys residues, previously shown to be critical for catalysis and substrate binding of potato tuber UGPase.	Lysine	127-130	UTP--glucose-1-phosphate uridylyltransferase	Solanum tuberosum	27-33
8666250-6	1996	The derived aa sequence of UGPase contains three putative N-glycosylation sites and has a highly conserved positioning of five Lys residues, previously shown to be critical for catalysis and substrate binding of potato tuber UGPase.	Lysine	127-130	UTP--glucose-1-phosphate uridylyltransferase	Solanum tuberosum	225-231
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Lysine	108-114	tyrosine aminotransferase	Homo sapiens	101-104
8631856-5	1996	Complexes which formed spontaneously by the interaction of the fusion protein with a luciferase reporter gene construct carrying a GAL4-specific recognition sequence, after condensation of the DNA and compensation of excess negative charge with poly-L-lysine were able to transfect ErbB-2-expressing cells in vitro in a cell-specific manner.	Lysine	245-258	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	131-135
18439419-2	2008	In this study, we found that the treatment with a p44/42 MAPK inhibitor, PD98059, induced di-methylation at lysine 9 on the upstream/transcriptional regions of the GLUT5 gene.	Lysine	108-114	interferon induced protein 44	Homo sapiens	50-53
2663650-7	1989	The Asn and Lys contents of the predicted protein are exceptionally high, these residues being particularly concentrated in the DHFR and junction domains.	Lysine	12-15	dihydrofolate reductase	Homo sapiens	128-132
18321858-4	2008	Based on PT1-docked AMPK alpha1 subunit structure model and different mutations, we found PT1 might interact with Glu-96 and Lys-156 residues near the autoinhibitory domain and directly relieve autoinhibition.	Lysine	125-128	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-31
2492530-9	1989	Thus, binding of heparin to human antithrombin diminished S-DABITC modification at Lys-107, Lys-125, and Lys-136, but at the same time enhanced S-DABITC modification at Lys-236.	Lysine	92-95	serpin family C member 1	Homo sapiens	34-46
8619628-1	1996	We showed that filaggrin linker segment peptide (FLSP) is a glutamine-rich substrate of epidermal transglutaminase (TGase), conjugating enzymatically with a phosphorylated cystatin alpha (P-cystatin alpha) which is a lysine-rich substrate of the enzyme.	Lysine	217-223	stefin A3	Rattus norvegicus	172-186
8641450-0	1996	The role of the C-terminal lysine in the hinge bending mechanism of yeast phosphoglycerate kinase.	Lysine	27-33	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	74-97
2912694-9	1989	Therefore, modification of lysine residues of histones by pyridoxal 5"-phosphate (Schiff base) presumably inhibited the binding of ASTP to the immobilized histone.	Lysine	27-33	glycerol kinase	Rattus norvegicus	131-135
18509048-5	2008	At the chromatin level, di- and trimethylation of lysine 4 of histone H3 (H3K4me2 and -3) near the Foxp3 transcription start site (TSS) and within the 5" untranslated region (UTR) preceded active Foxp3 expression and, like Foxp3 inducibility, was lost upon continued TCR stimulation.	Lysine	50-56	forkhead box P3	Homo sapiens	99-104
2915986-4	1989	A kinase-negative mutant EGFR (K721A), in which Lys-721 in the ATp binding site was replaced by an alanine residue, was shown to be phosphorylated in an EGF-dependent manner by an enzymatically active EGFR deletion mutant lacking two autophosphorylation sites.	Lysine	48-51	epidermal growth factor	Homo sapiens	25-28
8626612-13	1996	On the basis of our findings, we suggest a model in which Tat binds to TAR RNA by inserting the basic recognition sequence into the major groove with an orientation where lysine 41 in the core domain of Tat contacts the lower stem and Tyr47 is close to G26 of TAR RNA.	Lysine	171-177	tyrosine aminotransferase	Homo sapiens	58-61
18509048-5	2008	At the chromatin level, di- and trimethylation of lysine 4 of histone H3 (H3K4me2 and -3) near the Foxp3 transcription start site (TSS) and within the 5" untranslated region (UTR) preceded active Foxp3 expression and, like Foxp3 inducibility, was lost upon continued TCR stimulation.	Lysine	50-56	forkhead box P3	Homo sapiens	196-201
8626612-13	1996	On the basis of our findings, we suggest a model in which Tat binds to TAR RNA by inserting the basic recognition sequence into the major groove with an orientation where lysine 41 in the core domain of Tat contacts the lower stem and Tyr47 is close to G26 of TAR RNA.	Lysine	171-177	tyrosine aminotransferase	Homo sapiens	203-206
2668196-4	1989	Second, labeling with radioactive methionine or lysine gives a more intense beta 2m band with respect to the heavy chain than labeling with arginine or tyrosine.	Lysine	48-54	beta-2 microglobulin	Rattus norvegicus	76-83
18509048-5	2008	At the chromatin level, di- and trimethylation of lysine 4 of histone H3 (H3K4me2 and -3) near the Foxp3 transcription start site (TSS) and within the 5" untranslated region (UTR) preceded active Foxp3 expression and, like Foxp3 inducibility, was lost upon continued TCR stimulation.	Lysine	50-56	forkhead box P3	Homo sapiens	196-201
18481981-5	2008	K5 down-regulates cell-surface expression of the NKG2D ligands MICA/B (MHC class I-related chains A and B) by ubiquitination of MIC cytoplasmic tail lysine residues.	Lysine	149-155	killer cell lectin like receptor K1	Homo sapiens	49-54
3151991-7	1988	The flow of aspartate semialdehyde to either lysine or homoserine was influenced by the activity of homoserine dehydrogenase or dihydrodipicolinate synthase.	Lysine	45-51	dihydrodipicolinate synthase	Escherichia coli	128-156
3151991-10	1988	A similar increase of the flow of aspartate semialdehyde to lysine was found in strains with increased dihydrodipicolinate synthase activity, constructed by introducing the dapA gene of Escherichia coli (coding for the synthase) into C. glutamicum.	Lysine	60-66	dihydrodipicolinate synthase	Escherichia coli	103-131
8700867-0	1996	Single-amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase.	Lysine	42-48	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	69-97
8700867-1	1996	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) catalyzes the first step in biosynthesis of lysine in plants and bacteria.	Lysine	93-99	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-28
8700867-1	1996	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) catalyzes the first step in biosynthesis of lysine in plants and bacteria.	Lysine	93-99	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	30-34
8700867-2	1996	DHPS in plants is highly sensitive to end-product inhibition by lysine and, therefore, has an important role in regulating metabolite flux into lysine.	Lysine	64-70	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-4
8700867-2	1996	DHPS in plants is highly sensitive to end-product inhibition by lysine and, therefore, has an important role in regulating metabolite flux into lysine.	Lysine	144-150	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-4
8700867-3	1996	To better understand the feedback inhibition properties of the plant enzyme, we transformed a maize cDNA for lysine-sensitive DHPS into an Escherichia coli strain lacking DHPS activity.	Lysine	109-115	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	126-130
18481981-5	2008	K5 down-regulates cell-surface expression of the NKG2D ligands MICA/B (MHC class I-related chains A and B) by ubiquitination of MIC cytoplasmic tail lysine residues.	Lysine	149-155	MHC class I polypeptide-related sequence A	Homo sapiens	71-105
8700867-4	1996	Cells were mutagenized with ethylmethanesulfonate, and potential DHPS mutants were selected by growth on minimal medium containing the inhibitory lysine analogue S-2-aminoethyl-L-cysteine.	Lysine	146-152	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	65-69
8700867-5	1996	DHPS assays identified surviving colonies expressing lysine-insensitive DHPS activity.	Lysine	53-59	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-4
3138240-0	1988	A 13C NMR characterization of lysine residues in apolipoprotein B and their role in binding to the low density lipoprotein receptor.	Lysine	30-36	low density lipoprotein receptor	Homo sapiens	99-131
18481981-8	2008	This activity requires the K5 RING (really interesting new gene)-CH domain and AICL cytoplasmic tail lysine residues.	Lysine	101-107	C-type lectin domain family 2 member B	Homo sapiens	79-83
3138240-7	1988	The relative involvement of active and normal Lys in binding of apo B-100 to the LDL receptor on fibroblasts was explored by measuring the decrease in receptor binding as a function of the degree of methylation of the two types of Lys.	Lysine	46-49	low density lipoprotein receptor	Homo sapiens	81-93
8700867-7	1996	No other mutations were present in the remaining DHPS cDNA sequence, indicating that altering only one of the three residues suffices to eliminate lysine inhibition of maize DHPS.	Lysine	147-153	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	174-178
8700867-8	1996	Identification of these specific mutations that change the highly sensitive maize DHPS to a lysine-insensitive isoform will help resolve the lysine-binding mechanism and the resultant conformational changes involved in inhibition of DHPS activity.	Lysine	92-98	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	82-86
8700867-8	1996	Identification of these specific mutations that change the highly sensitive maize DHPS to a lysine-insensitive isoform will help resolve the lysine-binding mechanism and the resultant conformational changes involved in inhibition of DHPS activity.	Lysine	92-98	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	233-237
8700867-8	1996	Identification of these specific mutations that change the highly sensitive maize DHPS to a lysine-insensitive isoform will help resolve the lysine-binding mechanism and the resultant conformational changes involved in inhibition of DHPS activity.	Lysine	141-147	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	82-86
8700867-8	1996	Identification of these specific mutations that change the highly sensitive maize DHPS to a lysine-insensitive isoform will help resolve the lysine-binding mechanism and the resultant conformational changes involved in inhibition of DHPS activity.	Lysine	141-147	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	233-237
8700867-9	1996	The plant-derived mutant DHPS genes may also be used to improve nutritional quality of maize or other cereal grains that have inadequate lysine content when fed to animals such as poultry, swine, or humans.	Lysine	137-143	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	25-29
3265106-2	1988	and LY 171555 (0.625-20 mg/kg s.c.) showed clear evidence of dopamine D-1/D-2 behavioural interactions compared to either treatment given alone.	Lysine	4-6	solute carrier family 3 member 1	Rattus norvegicus	70-77
18519690-8	2008	This SS18-SSX binding correlates with trimethylation of Lys(27) of histone H3 (H3K27-M3) and recruitment of polycomb group proteins to this promoter.	Lysine	56-59	SSX family member 2	Homo sapiens	10-13
3138108-4	1988	The protein segment on the carboxy-terminal side of the human NF-H rod is uniquely long (greater than 600 amino acids) compared to other IF proteins and is highly charged (greater than 24% Glu, greater than 25% Lys), rich in proline (greater than 12%) and impoverished in cysteine, methionine and aromatic amino acids.	Lysine	211-214	neurofilament heavy chain	Homo sapiens	62-66
3132453-3	1988	In previous work with the Amadori rearrangement product N alpha-formyl-N epsilon-fructoselysine (fFL), an analog of glycated lysine residues in proteins, we showed that fFL was oxidatively cleaved between C-2 and C-3 of the carbohydrate chain to yield N epsilon-carboxymethyllysine (CML) and D-erythronic acid.	Lysine	89-95	complement C2	Homo sapiens	205-208
18558650-0	2008	Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.	Lysine	102-108	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	0-34
3283564-2	1988	We report here that lysates of insulin secretory granules contain two distinct Ca-dependent acidic endoproteases; one (type I) cleaving exclusively on the C-terminal side of Arg 31.Arg 32 (B-chain/C-peptide junction), the other (type II) preferentially on the C-terminal side of Lys 64.Arg 65 of proinsulin (C-peptide/A-chain junction).	Lysine	279-282	insulin 2	Rattus norvegicus	197-206
8552101-5	1996	Furthermore, a mutation in the AMT1 Cu-activated DNA binding domain which converts a single arginine, found in a conserved minor groove binding domain, to lysine markedly reduces AMT1 DNA binding affinity in vitro and results in a severe defect in the ability of C. glabrata cells to mount a protective response against Cu toxicity.	Lysine	155-161	ammonium permease MEP1	Saccharomyces cerevisiae S288C	31-35
8552101-5	1996	Furthermore, a mutation in the AMT1 Cu-activated DNA binding domain which converts a single arginine, found in a conserved minor groove binding domain, to lysine markedly reduces AMT1 DNA binding affinity in vitro and results in a severe defect in the ability of C. glabrata cells to mount a protective response against Cu toxicity.	Lysine	155-161	ammonium permease MEP1	Saccharomyces cerevisiae S288C	179-183
19040066-5	2008	RESULTS: The CYP17 genes of the patients were proved to hold a homozygous mutation with a base deletion and a base transversion (TAC/AA) in exon 6, which produced a missense mutation of Tyr--&gt;Lys at codon 329 and changed the open reading frame following this codon.	Lysine	195-198	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	13-18
8565073-4	1996	In a C-terminal truncated form of Ste2p that is rapidly ubiquitinated and endocytosed in response to ligand binding, a single lysine to arginine substitution in its cytoplasmic tail eliminates both ubiquitination and internalization.	Lysine	126-132	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	34-39
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Lysine	104-110	adenylate cyclase activating polypeptide 1	Rattus norvegicus	57-62
8579602-7	1996	As an aspartate is also present in position 3 of VIP and PACAP, two peptides related to secretin, and a lysine residue is conserved in the first extracellular loop of the VIP and PACAP receptors, this interaction may be a key element of peptide recognition by this receptor family.	Lysine	104-110	adenylate cyclase activating polypeptide 1	Rattus norvegicus	179-184
3125994-5	1988	Pre-treatment of the in situ BPDE-I-modified H2A.2 from rat liver with carboxypeptidase B, which should remove the C-terminal lysine from the protein, resulted in increased retention times on reverse-phase HPLC for the adduct-containing peptides upon subsequent V8-protease digestion.	Lysine	126-132	carboxypeptidase B1	Rattus norvegicus	71-89
3135547-8	1988	The binding site region of PAK2, which also binds Lys, resembles those of PGK1 and PGK4.	Lysine	50-53	phosphoglycerate kinase 1	Homo sapiens	74-78
18215125-13	2008	Recombinant neurobin processed 17-kDa FGF-2 (fibroblast growth factor-2) at several P(1) lysine and arginine positions to distinct fragments, in a heparin-inhibitable manner, but did not cleave FGF-7, laminin or fibronectin.	Lysine	89-95	fibroblast growth factor 2	Mus musculus	45-71
3117792-1	1987	The putative protein synthesis initiation factor eukaryotic initiation factor 4D (eIF-4D) is post-translationally modified by the polyamine spermidine, forming the rare amino acid hypusine from a lysine residue.	Lysine	196-202	eukaryotic translation initiation factor 5A	Homo sapiens	49-80
3117792-1	1987	The putative protein synthesis initiation factor eukaryotic initiation factor 4D (eIF-4D) is post-translationally modified by the polyamine spermidine, forming the rare amino acid hypusine from a lysine residue.	Lysine	196-202	eukaryotic translation initiation factor 5A	Homo sapiens	82-88
8549832-1	1996	Deoxyhypusine synthase is essentially required for the post-translational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A, which appears to be pivotal for cell proliferation.	Lysine	126-132	eukaryotic translation initiation factor 5A2	Homo sapiens	144-175
18467109-0	2008	Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors.	Lysine	45-51	alanyl aminopeptidase, membrane	Homo sapiens	63-80
18467109-0	2008	Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors.	Lysine	45-51	alanyl aminopeptidase, membrane	Homo sapiens	81-85
3040700-9	1987	Binding of mitochondrial cytochrome c but not of mitochondrial cytochrome c2 is strongly inhibited by low concentrations of poly-L-lysine.	Lysine	124-137	cytochrome c, somatic	Equus caballus	25-37
8622559-2	1996	This increasing effect was completely inhibited by aprotinin but not by tranexamic acid, thereby suggesting that the plasmin-induced stimulation of ET-1 release requires the catalytic site but not the lysine binding site, in plasmin molecule.	Lysine	201-207	plasminogen	Homo sapiens	117-124
18467109-1	2008	A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2).	Lysine	18-26	alanyl aminopeptidase, membrane	Homo sapiens	114-131
18467109-1	2008	A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2).	Lysine	18-26	alanyl aminopeptidase, membrane	Homo sapiens	133-136
3109489-9	1987	These studies indicated that the amino acids present in the active site of glyoxalase I from intestinal mucosa which may be important for activity are tyrosine, tryptophan, lysine and glutamic acid/aspartic acid residues.	Lysine	173-179	glyoxalase I	Homo sapiens	75-87
18467109-1	2008	A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2).	Lysine	18-26	alanyl aminopeptidase, membrane	Homo sapiens	138-142
18467109-1	2008	A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2).	Lysine	18-26	matrix metallopeptidase 2	Homo sapiens	147-173
18467109-1	2008	A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2).	Lysine	18-26	matrix metallopeptidase 2	Homo sapiens	175-180
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	NADPH oxidase 1	Homo sapiens	228-232
2436687-2	1987	Aprotinin has a Lys residue in the P1 (reactive center) position occupying residue 15.	Lysine	16-19	pancreatic trypsin inhibitor	Bos taurus	0-9
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	NADPH oxidase 4	Homo sapiens	268-272
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	NADPH oxidase 1	Homo sapiens	228-232
8983022-9	1996	Our results illustrate the potential of the CHO-D3-FUR cell line in the production of recombinant secretory proteins that need endoproteolytic activation at the consensus furin cleavage sequence Arg-X-Lys/Arg-Arg.	Lysine	201-204	furin, paired basic amino acid cleaving enzyme	Homo sapiens	171-176
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	NADPH oxidase 4	Homo sapiens	268-272
3028795-15	1987	Amino acid analysis of m-beta-2-m revealed that the protein is missing one lysine residue compared to the composition deduced from the cDNA sequence of beta-2-m.	Lysine	75-81	beta-2-microglobulin	Homo sapiens	25-33
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Lysine	103-106	acetylcholinesterase	Mus musculus	6-10
3028795-20	1987	Thus proteolytic cleavage of beta-2-m in the intrachain disulphide loop releases the amino acid Lys-58, which results in a modified form of beta-2-m with a molecular mass of 11,620 Da as determined by amino acid analysis.	Lysine	96-99	beta-2-microglobulin	Homo sapiens	29-37
3028795-20	1987	Thus proteolytic cleavage of beta-2-m in the intrachain disulphide loop releases the amino acid Lys-58, which results in a modified form of beta-2-m with a molecular mass of 11,620 Da as determined by amino acid analysis.	Lysine	96-99	beta-2-microglobulin	Homo sapiens	140-148
8616236-3	1996	Although the nucleotide and deduced amino acid sequences of these cDNAs are almost identical, the deduced HPR1 protein contains Ser-Lys-Leu at its carboxy-terminal end, which is known as a microbody-targeting signal, while the deduced HPR2 protein does not.	Lysine	132-135	THO complex 1	Homo sapiens	106-110
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Lysine	157-160	acetylcholinesterase	Mus musculus	6-10
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Lysine	157-160	acetylcholinesterase	Mus musculus	6-10
3024978-1	1986	The lysine reagent pyridoxal 5-phosphate was applied to the ADP/ATP carrier (AAC) in order to elucidate topological and functional properties of the numerous lysines within the primary structure.	Lysine	158-165	WD and tetratricopeptide repeats 1	Homo sapiens	60-75
24166118-0	1996	Lysine accumulation in maize cell cultures transformed with a lysine-insensitive form of maize dihydrodipicolinate synthase.	Lysine	0-6	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	95-123
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Lysine	157-160	acetylcholinesterase	Mus musculus	6-10
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	19-25	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	74-102
18241198-0	2008	A critical role in structure-specific DNA binding for the acetylatable lysine residues in HMGB1.	Lysine	71-77	high mobility group box 1	Homo sapiens	90-95
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	19-25	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	104-108
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	157-163	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	74-102
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	157-163	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	104-108
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	157-163	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	74-102
24166118-2	1996	Two enzymes in the lysine biosynthesis pathway, aspartate kinase (AK) and dihydrodipicolinate synthase (DHPS), have primary roles in regulating the level of lysine accumulation in plant cells because both enzymes are feedback-inhibited by lysine.	Lysine	157-163	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	104-108
24166118-3	1996	An isolated cDNA clone for maize DHPS was modified to encode a DHPS much less sensitive to lysine inhibition.	Lysine	91-97	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	33-37
24166118-3	1996	An isolated cDNA clone for maize DHPS was modified to encode a DHPS much less sensitive to lysine inhibition.	Lysine	91-97	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	63-67
24166118-4	1996	The altered DHPS cDNA was transformed into maize cell suspension cultures to determine the effect on DHPS activity and lysine accumulation.	Lysine	119-125	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	12-16
3790525-1	1986	The studies reported are concerned with the functional consequences of the chemical modifications of the lysines and carboxyl-containing amino acids of bovine rhodopsin.	Lysine	105-112	rhodopsin	Bos taurus	159-168
3790525-2	1986	The 10 non-active-site lysine residues of rhodopsin can be completely dimethylated and partially acetimidated (8-9 residues) with no loss in the ability of the proteins to activate the G protein when photolyzed or to regenerate with 11-cis-retinal.	Lysine	23-29	rhodopsin	Bos taurus	42-51
3790525-4	1986	Surprisingly, heavy acetylation of these lysines (eight to nine residues) with acetic anhydride, which neutralizes the positive charges of the lysine residues, yields a modified rhodopsin fully capable of activating the G protein and being regenerated.	Lysine	41-48	rhodopsin	Bos taurus	178-187
3790525-4	1986	Surprisingly, heavy acetylation of these lysines (eight to nine residues) with acetic anhydride, which neutralizes the positive charges of the lysine residues, yields a modified rhodopsin fully capable of activating the G protein and being regenerated.	Lysine	41-47	rhodopsin	Bos taurus	178-187
3790525-5	1986	It is concluded that the non-active-site lysine residues of rhodopsin are not importantly and directly involved in interactions with the G protein during photolysis.	Lysine	41-47	rhodopsin	Bos taurus	60-69
3790525-7	1986	The active-site lysine of rhodopsin was readily modified and prevented from regenerating with 11-cis-retinal and with o-salicylaldehyde and o-phthalaldehyde/mercaptoethanol, two sterically similar aromatic aldehyde containing reagents which react by entirely different mechanisms.	Lysine	16-22	rhodopsin	Bos taurus	26-35
3091599-0	1986	Effects of the binding of myosin light chain kinase on the reactivities of calmodulin lysines.	Lysine	86-93	myosin light chain kinase	Homo sapiens	26-51
18241198-1	2008	The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail, is acetylated in vivo at Lys(2) and Lys(11) in the A box.	Lysine	185-188	high mobility group box 1	Homo sapiens	43-48
24166118-5	1996	Partially purified DHPS (wildtype plus mutant) from transformed cultures was less sensitive to lysine inhibition than wild-type DHPS from nontransformed cultures.	Lysine	95-101	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	19-23
24166118-7	1996	Thus, we have shown that reducing the feedback inhibition of DHPS by lysine can lead to increased lysine accumulation in maize cells.	Lysine	69-75	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	61-65
24166118-7	1996	Thus, we have shown that reducing the feedback inhibition of DHPS by lysine can lead to increased lysine accumulation in maize cells.	Lysine	98-104	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	61-65
18241198-1	2008	The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail, is acetylated in vivo at Lys(2) and Lys(11) in the A box.	Lysine	185-188	high mobility group box 1	Homo sapiens	50-80
18241198-1	2008	The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail, is acetylated in vivo at Lys(2) and Lys(11) in the A box.	Lysine	196-199	high mobility group box 1	Homo sapiens	43-48
18241198-1	2008	The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail, is acetylated in vivo at Lys(2) and Lys(11) in the A box.	Lysine	196-199	high mobility group box 1	Homo sapiens	50-80
2422174-5	1986	Limited proteolysis of alpha 2M-methylamine with lysine-specific bacterial endoproteinase was examined by rate electrophoresis and by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to correlate the loss of the epitopes with the generation of defined fragments.	Lysine	49-55	alpha-2-macroglobulin	Homo sapiens	23-31
18241198-8	2008	We conclude that Lys(2) and Lys(11) are critical for binding of the isolated A domain and HMGB1 to distorted DNA substrates.	Lysine	17-20	high mobility group box 1	Homo sapiens	90-95
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Lysine	105-111	estrogen receptor 2	Homo sapiens	193-196
18241198-8	2008	We conclude that Lys(2) and Lys(11) are critical for binding of the isolated A domain and HMGB1 to distorted DNA substrates.	Lysine	28-31	high mobility group box 1	Homo sapiens	90-95
18363801-7	2008	The observed pattern of cleavage sites (Phe(18)-Lys(19) and Leu(17)-Phe(18)) is consistent with published in vitro studies of purified insulin-degrading enzyme cleavage of beta-endorphin.	Lysine	48-51	insulin degrading enzyme	Rattus norvegicus	135-159
7592852-6	1995	The TGase 3 reaction favored certain lysines and glutamines by forming mostly intrachain cross-links, whereas TGase 1 formed mostly large oligomeric complexes by interchain cross-links involving different lysines and glutamines.	Lysine	205-212	transglutaminase 1	Homo sapiens	110-117
2422647-1	1986	The complete amino acid sequence of the prostate-specific antigen (PA) from human seminal plasma has been determined from analyses of the peptides generated by cyanogen bromide, hydroxylamine, endoproteinases Arg-C and Lys-C.	Lysine	219-222	kallikrein related peptidase 3	Homo sapiens	40-70
2422647-7	1986	The cleavage sites of these proteins by PA were chemically analyzed as the alpha-carboxyl side of some hydrophobic residues, tyrosine, leucine, valine, and phenylalanine, and of basic residues histidine, lysine, and arginine.	Lysine	204-210	kallikrein related peptidase 3	Homo sapiens	40-42
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Lysine	252-255	thyrotropin-releasing hormone L homeolog	Xenopus laevis	20-49
3088682-2	1986	Peptides related to thyrotropin releasing hormone (TRH) were identified in the eluted fractions by trypsin digestion and radioimmunoassay (RIA) using antibodies to the TRH tripeptide pGlu-His-Pro amide or to a TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Lysine	252-255	thyrotropin-releasing hormone L homeolog	Xenopus laevis	51-54
3088682-5	1986	Evidence was also obtained for the presence of small amounts of the TRH-related pentapeptide pGlu-His-Pro-Gly-Lys.	Lysine	110-113	thyrotropin-releasing hormone L homeolog	Xenopus laevis	68-71
7585979-7	1995	Solid-phase assays with immobilized lactosylated poly-L-lysine demonstrated a comparatively lower affinity and higher extent of binding at saturation for the monomeric lectin than for the dimeric protein, whose properties were similar to those of an immunomodulatory plant lectin.	Lysine	49-62	galectin 3	Gallus gallus	168-174
7585979-7	1995	Solid-phase assays with immobilized lactosylated poly-L-lysine demonstrated a comparatively lower affinity and higher extent of binding at saturation for the monomeric lectin than for the dimeric protein, whose properties were similar to those of an immunomodulatory plant lectin.	Lysine	49-62	galectin 3	Gallus gallus	273-279
18053795-1	2008	A robust cross-link between Gln(23) in phospholamban (PLN) and Lys(328) in the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1a) is formed in the presence or absence of oxidant and is susceptible to both PLN phosphorylation and SERCA1a Ca(2+) binding.	Lysine	63-66	phospholamban	Homo sapiens	207-210
3082364-0	1986	Chemical modification of lysine and arginine residues in the myosin regulatory light chain inhibits phosphorylation.	Lysine	25-31	myosin heavy chain 14	Homo sapiens	61-67
18270205-6	2008	We show that Otu1 binds polyubiquitin chain analogs more tightly than monoubiquitin and preferentially hydrolyzes longer polyubiquitin chains with Lys(48) linkages, having little or no activity on Lys(63)- and Lys(29)-linked chains.	Lysine	147-150	ubiquitin-specific protease OTU1	Saccharomyces cerevisiae S288C	13-17
3943547-6	1986	Using fibronectin in which lysine residues were radioiodinated, an apparent Kd for binding to mixed rat liver gangliosides of 7.8 X 10(-9) M was determined.	Lysine	27-33	fibronectin 1	Rattus norvegicus	6-17
3943547-7	1986	This value compared favorably with the apparent Kd for attachment of fibronectin to isolated plasma membranes from rat liver of 3.7 X 10(-9) M for fibronectin modified on the tyrosine residue, or 6.4 X 10(-9) M for fibronectin modified on lysine residues.	Lysine	239-245	fibronectin 1	Rattus norvegicus	69-80
3943547-10	1986	In contrast, lysine-modified fibronectin both bound to cells and promoted cell attachment.	Lysine	13-19	fibronectin 1	Rattus norvegicus	29-40
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Lysine	79-85	cerebellar degeneration related protein 2	Homo sapiens	65-69
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Lysine	79-85	cerebellar degeneration related protein 2	Homo sapiens	162-166
7473721-2	1995	For example, an alanine residue at H71 provides room for packing CDR2/CDR1 and lysine residues at H73 and H93 contribute a salt-bridge to aspartic acid at H55 in CDR2 and a hydrogen bond to the carbonyl group at H96 in CDR3, respectively.	Lysine	79-85	CDR3	Homo sapiens	219-223
18008394-10	2008	These results suggested that in regenerating liver, enhanced the formation of Gln-Lys bonds catalyzed by TG2 led to reduced DNA synthesis, whereas when ODC produced newly synthesized SPD, the inhibition of Gln-Lys bond production by the preferential formation of protein-SPD bonds led to an increase in DNA synthesis.	Lysine	82-85	transglutaminase 2	Rattus norvegicus	105-108
8561277-8	1995	ALDH2(2Taiwan) is characterized by two G--&gt;A transitions at bases 1486 and 1510, resulting in Glu--&gt;Lys substitutions at both the 479 and 487 positions.	Lysine	106-109	aldehyde dehydrogenase 2 family member	Homo sapiens	0-5
3937555-0	1985	Methylation of the active-site lysine of rhodopsin.	Lysine	31-37	rhodopsin	Bos taurus	41-50
3937555-2	1985	Rhodopsin contains 10 non-active-site lysines, which account for the uptake of the 20 methyl groups.	Lysine	38-45	rhodopsin	Bos taurus	0-9
3937555-4	1985	The critical active-site lysine of permethylated rhodopsin can be liberated by photolysis.	Lysine	25-31	rhodopsin	Bos taurus	49-58
18008394-10	2008	These results suggested that in regenerating liver, enhanced the formation of Gln-Lys bonds catalyzed by TG2 led to reduced DNA synthesis, whereas when ODC produced newly synthesized SPD, the inhibition of Gln-Lys bond production by the preferential formation of protein-SPD bonds led to an increase in DNA synthesis.	Lysine	210-213	transglutaminase 2	Rattus norvegicus	105-108
18178186-5	2008	Transfection of primary rat neurons with ADAMTS4 cDNA induced longer neurites, whether the neurons were grown on a monolayer of astrocytes that secrete inhibitory PGs or on laminin/poly-L-lysine substrate alone.	Lysine	181-194	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	41-48
2863142-7	1985	The results suggested essential tryptophan, lysine and histidine residues at a common catalytic site for pseudocholinesterase and aryl acylamidase and an arginine residue (or residues) exclusively for pseudocholinesterase.	Lysine	44-50	butyrylcholinesterase	Homo sapiens	105-125
7665569-2	1995	The function of a lysine residue, Lys950, of human DNA polymerase alpha located in the third most conserved region and conserved in all of the alpha-like polymerases was analyzed by site-directed mutagenesis.	Lysine	18-24	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	51-71
7665584-6	1995	There are three serines in the sequence of eIF-4E that are three residues away from a tryptic cleavage site (i.e. lysine or arginine).	Lysine	114-120	eukaryotic translation initiation factor 4E	Cricetulus griseus	43-49
7665584-7	1995	32P-Labeled eIF-4E was digested with trypsin, Lys-C, or trypsin followed by Glu-C and subjected to two-dimensional mapping; the data obtained eliminated two of these potential sites, leaving Ser-209.	Lysine	46-49	eukaryotic translation initiation factor 4E	Cricetulus griseus	12-18
18267969-3	2008	Here the role of a conserved lysine residue in the smaller tier or collar of the E1 helicase domain in ori processing is described.	Lysine	29-35	helicase for meiosis 1	Homo sapiens	84-92
7557423-0	1995	Cloning and characterization of the Saccharomyces cerevisiae LYS7 gene: evidence for function outside of lysine biosynthesis.	Lysine	105-111	copper chaperone CCS1	Saccharomyces cerevisiae S288C	61-65
7557423-5	1995	The lys7 delta mutant requires lysine and simultaneously displays an array of phenotypes that include pH and temperature sensitivity.	Lysine	31-37	copper chaperone CCS1	Saccharomyces cerevisiae S288C	4-8
7557423-6	1995	The pleiotropic phenotypes of the lys7 delta mutant and the constitutive transcription pattern are at odds with the hypothesis that Lys7p functions solely in the lysine biosynthesis pathway.	Lysine	162-168	copper chaperone CCS1	Saccharomyces cerevisiae S288C	34-38
2988154-8	1985	3,4-DAP induced asynchronous end-plate potentials in response to nerve stimulation in type F-paralyzed muscles, but not in muscles treated with type A. Amidination of the amino groups (presumably lysine) on the toxin by treatment with ethylacetimidate increased the potency and efficacy of only type F BoTx.	Lysine	196-202	death-associated protein	Rattus norvegicus	4-7
3988754-3	1985	Free lysyl-tRNA synthetase dissociated from the synthetase complex is about 6-fold more active than the complex in AppppA synthesis, while their apparent Michaelis constants for ATP and lysine are similar.	Lysine	186-192	lysyl-tRNA synthetase 1	Rattus norvegicus	5-26
7557423-6	1995	The pleiotropic phenotypes of the lys7 delta mutant and the constitutive transcription pattern are at odds with the hypothesis that Lys7p functions solely in the lysine biosynthesis pathway.	Lysine	162-168	copper chaperone CCS1	Saccharomyces cerevisiae S288C	132-137
18020317-2	2008	The RXR-SRC1 interactions in three types of RXR-9cRA-SRC1 complexes, namely, a wild type (WT), a mutant whose Glu453 of AF2C was substituted by Lys (E453K), and another mutant whose Glu456 of AF2C was substituted by Lys (E456K), were compared.	Lysine	216-219	nuclear receptor coactivator 1	Homo sapiens	8-12
18239466-4	2008	The first 7 amino acid residues of Sp1 enhance the accessibility of Lysine-16 to the homologous modifiers SUMO-1 and ubiquitin; and Serine-7 specifically enhances ubiquitinylation.	Lysine	68-74	small ubiquitin like modifier 1	Homo sapiens	106-112
3979448-6	1985	Adherence to a substratum was determined to be a second required signal for expression of FcR, since PMA induction of P388 tumor cells in teflon dishes failed to fully develop FcR and adherence of P388 cells to poly-L-lysine-coated culture dishes in the absence of PMA was insufficient for FcR expression.	Lysine	211-224	Fc receptor	Mus musculus	90-93
17998425-2	2008	Cationic AA transporter-1 (CAT-1) is a major intestinal CAA transporter, demonstrating a high-affinity (muM) transport activity for l-Lys in other mammals, and is widely expressed by small intestinal epithelia of nonruminants, but neither sequence nor expression pattern data exist for CAT-1 in cattle.	Lysine	132-137	solute carrier family 7 member 1	Bos taurus	0-25
2983103-4	1985	The presence of a lysine residue in position 12 of BALB/c murine sarcoma virus p21 likely accounts for its oncogenic properties.	Lysine	18-24	H3 histone pseudogene 16	Homo sapiens	79-82
7638617-5	1995	The Gal6 channel is lined with 60 lysine residues from the six subunits, suggesting a role in DNA binding.	Lysine	34-40	bleomycin hydrolase	Saccharomyces cerevisiae S288C	4-8
18079109-5	2008	The UBA domain of CIP75 is the main element mediating the interaction with Cx43, whereas the CIP75-interacting region in Cx43 resides in the PY motif and multiphosphorylation sites located between Lys 264 and Asn 302.	Lysine	197-200	gap junction protein alpha 1	Homo sapiens	121-125
8533120-6	1995	The results are interpreted to suggest that CNBr-Fbg and 6-AH compete with each other for the same lysine binding sites (LBS) on the Plg molecule while fucoidan acted synergistically with 6-AH in enhancing the t-PA activation of Glu-Plg by a different mechanism.	Lysine	99-105	plasminogen	Homo sapiens	133-136
3985748-6	1985	The carboxy-terminal amino acid sequence-Lys-Arg of the fragment was identical to that obtained from colicin M.	Lysine	41-44	Colicin-M	Escherichia coli	101-110
3985748-7	1985	Release of lysine and arginine led to inactivation of colicin M.	Lysine	11-17	Colicin-M	Escherichia coli	54-63
18197703-5	2008	The acidic region of the extension is also dispensable for thermotolerance and for the stimulation of Hsp104 ATPase activity by poly-l-lysine, but its truncation results in an oligomerization defect and reduced ATPase activity in vitro.	Lysine	128-141	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	102-108
3001768-4	1985	The large abundance of lysine and arginine residues in the DBI molecule suggest that this polypeptide functions as a precursor of a putative endocoid which regulates anxiety levels.	Lysine	23-29	diazepam binding inhibitor	Rattus norvegicus	59-62
7549063-6	1995	The lysine binding sites situated in the kringle structures of plasminogen play a crucial role in the regulation of fibrinolysis by modulating its binding to fibrin and to cell surfaces, and by controlling the inhibition rate of plasmin by alpha 2-antiplasmin.	Lysine	4-10	plasminogen	Homo sapiens	63-70
7582119-4	1995	When a recombinantly expressed fragment of TrkA comprising the two immunoglobulin-like domains was coated as a substrate in combination with poly-L-lysine and laminin, neurite outgrowth was inhibited in a dose-dependent manner.	Lysine	141-154	neurotrophic receptor tyrosine kinase 1	Homo sapiens	43-47
18201069-2	2008	However, previous cross-linking studies on model proteins, such as cytochrome c and ribonuclease A, identified a limited number of peptide cross-links that are biased toward only a few of the potentially reactive lysine residues.	Lysine	213-219	LOC104968582	Bos taurus	67-79
2860689-0	1985	Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK &amp; F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats.	Lysine	141-143	solute carrier family 3 member 1	Rattus norvegicus	0-48
7791116-7	1995	At native rat 5-HT1A receptors and cloned human 5-HT1A receptors, LY 165,163 (pKi values of 8.7 and 8.9, respectively) mimicked the high affinity of 8-OH-DPAT (pKi values of 9.0 and 9.2).	Lysine	66-68	5-hydroxytryptamine receptor 1A	Rattus norvegicus	10-20
18063813-1	2008	Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) exerts an antifibrinolytic effect by removing C-terminal lysines from partially degraded fibrin.	Lysine	119-126	carboxypeptidase B2	Homo sapiens	10-53
7791116-12	1995	Further, STFs evoked by LY 165,163 in the presence of apomorphine were abolished by the 5-HT1A antagonists (-)-alprenolol, BMY 7378 and NAN-190.	Lysine	24-26	5-hydroxytryptamine receptor 1A	Rattus norvegicus	88-94
16453580-4	1984	We suggest that the main function of phosphorylation of sp-Ia and sp-Ib is to provide charge neutralization of an excess of lysine and arginine residues and is therefore required during early stages of protein folding.	Lysine	124-130	Spi-1 proto-oncogene	Homo sapiens	56-71
18282128-2	2008	Like ubiquitin, the SUMOs are protein modifiers that are covalently attached to the epsilon-amino group of lysine residues in the substrates.	Lysine	107-113	ubiquitin	Saccharomyces cerevisiae S288C	5-14
6432788-3	1984	[Methyl-3H] Lys(Me3)-labeled agalacto-orosomucoid (AGOR) and asialofetuin were rapidly taken up and degraded by the perfused liver.	Lysine	12-15	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	16-19
6432788-4	1984	Most of the free Lys(Me3) derived from Lys(Me3)-AGOR was released unmodified into the perfusion medium.	Lysine	17-20	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	21-24
6432788-4	1984	Most of the free Lys(Me3) derived from Lys(Me3)-AGOR was released unmodified into the perfusion medium.	Lysine	17-20	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	43-46
6432788-4	1984	Most of the free Lys(Me3) derived from Lys(Me3)-AGOR was released unmodified into the perfusion medium.	Lysine	39-42	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	21-24
6432788-4	1984	Most of the free Lys(Me3) derived from Lys(Me3)-AGOR was released unmodified into the perfusion medium.	Lysine	39-42	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	43-46
7744838-5	1995	Substitution of Arg-83 with amino acids of diverse structures including Lys, a conservative change, yielded mutant G6Pase with no enzymatic activity.	Lysine	72-75	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	115-121
6432788-5	1984	However, Lys(Me3), arising from Lys(Me3)-asialofetuin was converted mostly to gamma-butyrobetaine and carnitine.	Lysine	9-12	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	13-16
18415985-4	2008	CRTAase catalyzed the acetylation of a receptor protein nNOS, by a model PA 7, 8-diacetoxy-4-methylcoumarin (DAMC), which was visually confirmed by using antiacetyl lysine.	Lysine	165-171	nitric oxide synthase 1	Homo sapiens	56-60
6432788-5	1984	However, Lys(Me3), arising from Lys(Me3)-asialofetuin was converted mostly to gamma-butyrobetaine and carnitine.	Lysine	9-12	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	36-39
6432788-5	1984	However, Lys(Me3), arising from Lys(Me3)-asialofetuin was converted mostly to gamma-butyrobetaine and carnitine.	Lysine	32-35	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	13-16
6432788-5	1984	However, Lys(Me3), arising from Lys(Me3)-asialofetuin was converted mostly to gamma-butyrobetaine and carnitine.	Lysine	32-35	NADP-dependent malic enzyme, mitochondrial	Cavia porcellus	36-39
6148101-2	1984	In order to prevent epsilon-(gamma-glutamyl)lysine cross-link formation, the lysine residues of beta-casein were first blocked either by amidination with ethyl acetimidate or by acylation with succinic anhydride.	Lysine	44-50	casein beta	Homo sapiens	96-107
7750572-1	1995	Post-translational modification of a specific lysine residue in eukaryotic initiation factor 5A is essential for cell viability.	Lysine	46-52	eukaryotic translation initiation factor 5A2	Homo sapiens	64-95
7721768-2	1995	This NAD-dependent enzyme catalyzes the formation of deoxyhypusine by transfer of the butylamine portion of spermidine to the epsilon-amino group of a specific lysine residue in the eIF-5A precursor.	Lysine	160-166	eukaryotic translation initiation factor 5A	Rattus norvegicus	182-188
18415985-6	2008	For this purpose, purified nNOS was incubated with DAMC and CRTAase, the modified nNOS was analyzed by nanoscale LC-MS/MS, which recorded 11 distinct peptides with a significant score as acetylated on lysine residues.	Lysine	201-207	nitric oxide synthase 1	Homo sapiens	27-31
18020402-3	2008	It is possible to extend the circulating half-life of IFN-alpha2 by random modification of lysine residues in the protein with polyethylene glycol (PEG); however, such preparations have heterogeneous structures and low specific activities, and may not provide optimal therapeutic benefits to patients.	Lysine	91-97	interferon alpha 2	Homo sapiens	54-64
6329306-6	1984	Here we show that kringle 4, carboxymethylated on Cys-1 and Cys-79, regains its lysine-Sepharose affinity following denaturation and reductive cleavage of its disulphide bonds.	Lysine	80-86	cystin 1	Homo sapiens	50-55
18499250-0	2008	The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails.	Lysine	80-86	recombination activating protein 2-like	Strongylocentrotus purpuratus	47-54
6725400-9	1984	When cultured on ECM, however, 50-70% of the newly synthesized tropoelastin remains associated with the cell layer and is cross-linked to form insoluble elastin as shown by the incorporation of radiolabeled lysine into desmosine.	Lysine	207-213	elastin	Bos taurus	63-75
6725400-9	1984	When cultured on ECM, however, 50-70% of the newly synthesized tropoelastin remains associated with the cell layer and is cross-linked to form insoluble elastin as shown by the incorporation of radiolabeled lysine into desmosine.	Lysine	207-213	elastin	Bos taurus	68-75
7890760-5	1995	Wild type recombinant Lp(a) (r-Lp(a)) revealed lysine binding in the range observed for human plasma Lp(a).	Lysine	47-53	lipoprotein(a)	Homo sapiens	31-36
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	20-26	lipoprotein(a)	Homo sapiens	43-48
18178771-5	2008	All four Uev1 proteins can form a stable complex with At Ubc13 or with Ubc13 from yeast or human and can promote Ubc13-mediated Lys-63 polyubiquitination.	Lysine	128-131	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	57-62
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	20-26	lipoprotein(a)	Homo sapiens	114-119
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	20-26	lipoprotein(a)	Homo sapiens	162-168
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	20-26	lipoprotein(a)	Homo sapiens	241-247
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	84-90	lipoprotein(a)	Homo sapiens	43-48
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	84-90	lipoprotein(a)	Homo sapiens	114-119
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	84-90	lipoprotein(a)	Homo sapiens	43-48
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Lysine	84-90	lipoprotein(a)	Homo sapiens	114-119
6717443-5	1984	Comparison of this sequence with those of other H-2 class I molecules revealed that: (1) Lys-19, Val-55, Glu-56, Asn-63 and Ile-73 are unique to the H-2Kk molecule; and (2) H-2Kk shares 79-83% homology in this region with other mouse class I molecules.	Lysine	89-92	histocompatibility 2, K1, K region	Mus musculus	149-154
7890760-7	1995	Evidence is also presented for additional lysine-binding sites within kringles 32-36 of apo(a) that are masked in Lp(a) as indicated by an increased lysine binding for the point mutant (Cys-4057--&gt;Ser), which is unable to assemble into particles.	Lysine	42-48	lipoprotein(a)	Homo sapiens	88-94
18178771-5	2008	All four Uev1 proteins can form a stable complex with At Ubc13 or with Ubc13 from yeast or human and can promote Ubc13-mediated Lys-63 polyubiquitination.	Lysine	128-131	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	71-76
7890760-7	1995	Evidence is also presented for additional lysine-binding sites within kringles 32-36 of apo(a) that are masked in Lp(a) as indicated by an increased lysine binding for the point mutant (Cys-4057--&gt;Ser), which is unable to assemble into particles.	Lysine	42-48	lipoprotein(a)	Homo sapiens	114-119
7890760-7	1995	Evidence is also presented for additional lysine-binding sites within kringles 32-36 of apo(a) that are masked in Lp(a) as indicated by an increased lysine binding for the point mutant (Cys-4057--&gt;Ser), which is unable to assemble into particles.	Lysine	149-155	lipoprotein(a)	Homo sapiens	88-94
7890760-7	1995	Evidence is also presented for additional lysine-binding sites within kringles 32-36 of apo(a) that are masked in Lp(a) as indicated by an increased lysine binding for the point mutant (Cys-4057--&gt;Ser), which is unable to assemble into particles.	Lysine	149-155	lipoprotein(a)	Homo sapiens	114-119
7890760-8	1995	An important role of these lysine-binding site(s) for Lp(a) assembly is suggested by a decreased assembly efficiency for deletion mutants lacking either kringle 32 or kringles 32-35.	Lysine	27-33	lipoprotein(a)	Homo sapiens	54-59
6420409-6	1984	To further examine the role of lysine residues in the interaction of antithrombin III with heparin, the protein was singly labeled with pyridoxyl phosphate and affinity fractionated on heparin-agarose.	Lysine	31-37	serpin family C member 1	Homo sapiens	69-85
18166651-5	2007	We further demonstrate that pRb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes.	Lysine	118-124	RB transcriptional corepressor 1	Homo sapiens	28-31
6436641-0	1984	Methylated lysines and 3-methylhistidine in myosin: tissue and developmental differences.	Lysine	11-18	myosin heavy chain 14	Homo sapiens	44-50
6091699-1	1983	Preparations of horse heart cytochrome c have been obtained immobilized on Sepharose derivatives via lysine epsilon-amino groups, carboxyl groups of aspartic and glutamic acid residues, methionine and histidine residues as well as imidazole groups additionally introduced by means of chemical modification of free carboxyl groups by histamine.	Lysine	101-107	cytochrome c, somatic	Equus caballus	28-40
6091699-2	1983	Dissociation constants have been determined for complexes of adrenodoxin, hepatoredoxin, cytochrome b5 heme-containing fragment and myoglobin with preparations of cytochrome c immobilized via lysine residues (adsorbent I) or additionally introduced imidazole groups (adsorbent II).	Lysine	192-198	cytochrome c, somatic	Equus caballus	163-175
18158901-5	2007	In contrast, 53BP1 functions in XRCC4-dependent nonhomologous end-joining, likely mediated by its interaction with dimethylated lysine 20 of histone H4 but, surprisingly, independent of H2AX.	Lysine	128-134	X-ray repair cross complementing 4	Homo sapiens	32-37
7696314-6	1995	It is concluded that plasmin substrates containing a lysine residue have a general capacity to enhance plasminogen activation presumably by inducing a conformational change in the native zymogen in a manner similar to 6-aminohexanoate, while the same substrates are inhibitory both on the amidolytic activity of sc-tPA and the activation of native and des1-77-plasminogen by sc-tPA.	Lysine	53-59	plasminogen	Homo sapiens	21-28
6873065-5	1983	The imidate compound was found to react with a high specificity with only one lysine residue of ribosomal protein L7/L12.	Lysine	78-84	ribosomal protein L12	Homo sapiens	117-120
20641798-8	2004	alpha-MSH (Ac-Ser(1)-Tyr(2)-Ser(3)-Met(4)-Glu(5)-His(6)-Phe(7)-Arg(8)-Trp(9)-Gly(10)-Lys(11)-Pro(12)-Val(13)-NH2), composed of 13 amino acids, is the most potent naturally occurring melanotropic peptide (5).	Lysine	85-88	pro-opiomelanocortin-alpha	Mus musculus	0-9
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	70-73	cytochrome b5 type A	Homo sapiens	22-35
7749848-0	1995	Lysine modification of LDL or lipoprotein(a) by 4-hydroxynonenal or malondialdehyde decreases platelet serotonin secretion without affecting platelet aggregability and eicosanoid formation.	Lysine	0-6	lipoprotein(a)	Homo sapiens	30-44
7749848-4	1995	In contrast to native lipoproteins, HNE- or MDA-modified LDL and Lp(a) (approximately 20% to 30% of total apolipoprotein lysine residues modified) exerted a pronounced dose-dependent inhibition of 5-HT release from activated platelets in the following order: HNE LDL (50%) &gt; HNE Lp(a) (40%) &gt; MDA LDL (20%) &gt; MDA Lp(a) (5%).	Lysine	121-127	lipoprotein(a)	Homo sapiens	65-70
7749848-5	1995	Preincubation of human blood platelets with acetylated LDL or Lp(a) (approximately 60% to 70% of total lysine residues modified) prior to aggregation impaired serotonin secretion by 50% compared with native LDL or Lp(a).	Lysine	103-109	lipoprotein(a)	Homo sapiens	62-67
7749849-4	1995	Approximately 3% of the lysines of both Lp(a) and LDL were modified, which is a level comparable with that observed in LDL isolated from diabetic individuals.	Lysine	24-31	lipoprotein(a)	Homo sapiens	40-45
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	70-73	cytochrome b5 type A	Homo sapiens	113-126
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	cytochrome b5 type A	Homo sapiens	22-35
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	cytochrome b5 type A	Homo sapiens	113-126
18082607-4	2007	The RING finger-like structure of the PHD domain is required for both Ubc9 binding and sumoylation and directs modification to specific lysine residues in the bromodomain.	Lysine	136-142	ubiquitin conjugating enzyme E2 I	Homo sapiens	70-74
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	cytochrome b5 type A	Homo sapiens	22-35
6863249-4	1983	For the alpha-chain X cytochrome b5 complex, alpha-chain residues 56 (Lys), 60 (Lys), and 90 (Lys) interact with cytochrome b5 residues 44 (Glu), 43 (Glu), and 60 (Asp) respectively.	Lysine	80-83	cytochrome b5 type A	Homo sapiens	113-126
6863249-5	1983	A fourth hydrogen bond involves alpha-61 (Lys) bridging between a heme propionate from cytochrome b5 and a heme propionate from the alpha-chain.	Lysine	42-45	cytochrome b5 type A	Homo sapiens	87-100
6304037-5	1983	(CDNP lysine 72 cytochrome c yields a 3.6-fold decrease in the bimolecular rate constant, as compared to that for the native protein.)	Lysine	6-12	cytochrome c, somatic	Equus caballus	16-28
7862131-1	1995	Mutants of Saccharomyces cerevisiae lacking a functional SOD1 gene encoding Cu/Zn superoxide dismutase (SOD) are sensitive to atmospheric levels of oxygen and are auxotrophic for lysine and methionine when grown in air.	Lysine	179-185	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	57-61
7873529-8	1995	These results indicate that HPRG has independent binding sites for heparin and PLG and confirm that one or more lysine residues of HPRG are involved in its recognition by PLG.	Lysine	112-118	plasminogen	Homo sapiens	171-174
6304037-7	1983	(CDNP-lysine 27 cytochrome c exhibits a 7.3-fold increase in the rate constant, as compared to that for the native protein.)	Lysine	6-12	cytochrome c, somatic	Equus caballus	16-28
18077430-5	2007	We found that the JAZF1-JJAZ1 fusion restored levels of the polycomb protein EZH2 and histone 3 lysine 27 trimethylation, which were reduced by knockdown of endogenous JJAZ1.	Lysine	96-102	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	24-29
6870827-4	1983	The sequence analysis of the latter showed that the retinal-binding lysine residue was located at position 296 from the N-terminal of rhodopsin (or residue 53 from the C-terminal).	Lysine	68-74	rhodopsin	Bos taurus	134-143
7863976-4	1995	These studies show that human kringle 4-37 is mutable and that mutations in this kringle can affect the lysine-binding properties of apo(a) and, perhaps, the atherothrombogenic potential of Lp(a).	Lysine	104-110	lipoprotein(a)	Homo sapiens	190-195
18077430-5	2007	We found that the JAZF1-JJAZ1 fusion restored levels of the polycomb protein EZH2 and histone 3 lysine 27 trimethylation, which were reduced by knockdown of endogenous JJAZ1.	Lysine	96-102	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	168-173
18048344-4	2007	Overexpression of JARID1B resulted in loss of tri-, di-, and monomethyl H3K4 but did not affect other histone lysine methylations.	Lysine	110-116	lysine demethylase 5B	Homo sapiens	18-25
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Lysine	179-182	furin, paired basic amino acid cleaving enzyme	Homo sapiens	51-56
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Lysine	179-182	furin, paired basic amino acid cleaving enzyme	Homo sapiens	139-144
6404277-1	1983	Biproduct analogs of lysine and arginine are potent inhibitors of enkephalin convertase, a carboxypeptidase B-like enzyme which appears to be physiologically associated with enkephalin biosynthesis.	Lysine	21-27	carboxypeptidase E	Homo sapiens	66-87
6290485-8	1982	Modification of lysine residues of LDL abolished receptor activity in both normal and FHC cells.	Lysine	16-22	low density lipoprotein receptor	Homo sapiens	86-89
18048344-9	2007	Thus, we identified JARID1B as a demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer.	Lysine	101-107	lysine demethylase 5B	Homo sapiens	20-27
17884027-16	2007	Notably, HDAC inhibition also resulted in remarkable acetylation of p38 at lysine residues.	Lysine	75-81	mitogen-activated protein kinase 14	Mus musculus	68-71
6179939-14	1982	The sequence Arg-Lys precedes somatostatin-14.	Lysine	17-20	somatostatin-1	Ictalurus punctatus	30-45
7840619-6	1995	In combination, the above findings indicate that PLP interacts with the tricarboxylate transporter at a site(s) (i.e., a lysine residue(s) and/or the amino-terminal alanine residue) that is important in the translocation mechanism and may reside within or near the substrate binding site.	Lysine	121-127	pyridoxal phosphatase	Homo sapiens	49-52
7840781-8	1995	Antibodies raised against a truncated peptide (Tyr-Lys-Asp-Asn), representing the C-terminal half of the peptide, also bound to glucose-6-phosphate dehydrogenase, but failed to bind to CYP1A2; thus although the C-terminal region of the peptide 290-296 is strongly immunogenic, it appears that it is not this population of antibodies that binds to CYP1A2.	Lysine	51-54	glucose-6-phosphate dehydrogenase	Rattus norvegicus	128-161
18042460-2	2007	Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark.	Lysine	107-113	chromodomain helicase DNA binding protein 1	Homo sapiens	26-30
8545239-2	1995	Such effect was associated to increases in both IP3 production and [Ca++]i. Interestingly, these effects of Gly-His-Lys were antagonized by losartan, a nonpeptide angiotensin II receptor antagonist (AT1 selective), which suggested that these receptors were involved in its effect.	Lysine	116-119	angiotensin II receptor type 1	Homo sapiens	199-202
6127673-6	1982	Somatostatin-22 is homologous to somatostatin-14 in 7 of the 14 amino acids, including the Phe-Trp-Lys sequence.	Lysine	99-102	somatostatin-1	Ictalurus punctatus	33-48
18042461-0	2007	Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.	Lysine	27-33	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	87-94
8545239-3	1995	Binding competition experiments using the radioligand [125I][Sar1-Ile8]angiotensin II clearly indicated that Gly-His-Lys interacts with AT1 receptors.	Lysine	117-120	angiotensin II receptor type 1	Homo sapiens	136-139
6807983-0	1982	Inhibition of oxygen exchange by chemical modifiers at the sulfhydryl 1 or reactive lysine residue of myosin.	Lysine	84-90	myosin heavy chain 14	Homo sapiens	102-108
18042461-1	2007	Human L3MBTL1, which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimethylated lysines, in several histone sequence contexts.	Lysine	111-118	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	6-13
6807983-4	1982	We have performed this kind of analysis with two different forms of modified myosin, containing either N-ethylmaleimide at the sulfhydryl 1 group or trinitrophenyl at the reactive lysine residue.	Lysine	180-186	myosin heavy chain 14	Homo sapiens	77-83
7581493-4	1995	The Ahr protein has two different structures, ascribed to one amino acid replacement at codon 554 of Arg by Lys.	Lysine	108-111	aryl hydrocarbon receptor	Homo sapiens	4-7
6807983-5	1982	Although these modifications of the protein are chemically different, and the sulfhydryl 1 group and the reactive lysine residue are far apart in the primary chain of the myosin head, the two modifications caused a similar marked inhibition of oxygen exchange.	Lysine	114-120	myosin heavy chain 14	Homo sapiens	171-177
18042461-1	2007	Human L3MBTL1, which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimethylated lysines, in several histone sequence contexts.	Lysine	142-149	L3MBTL histone methyl-lysine binding protein 1	Homo sapiens	6-13
17948050-6	2007	TRAF6 associates with Malt1 in response to T-cell activation and can function as an E3 ligase for Malt1 in vitro and in vivo, mediating lysine 63-linked ubiquitination of Malt1.	Lysine	136-142	MALT1 paracaspase	Homo sapiens	98-103
6279635-8	1982	The interaction domain for the reaction with cytochrome c reductase includes in decreasing order of involvement lysines 13, 72, 86, 27, and 87.	Lysine	112-119	cytochrome c, somatic	Equus caballus	45-57
6279635-9	1982	That for the reaction with cytochrome c oxidase is slightly smaller, with lysines 13, 72, 86, and 27.	Lysine	74-81	cytochrome c, somatic	Equus caballus	27-39
6279635-10	1982	The cytochrome c peroxidase domain is the largest of all and is defined by lysines 72, 86, 13, 87, 27,, and 73.	Lysine	75-82	cytochrome c, somatic	Equus caballus	4-16
7528219-4	1994	The lysine analog epsilon-aminocaproic acid competitively inhibited plasmin binding.	Lysine	4-10	plasminogen	Homo sapiens	68-75
17948050-6	2007	TRAF6 associates with Malt1 in response to T-cell activation and can function as an E3 ligase for Malt1 in vitro and in vivo, mediating lysine 63-linked ubiquitination of Malt1.	Lysine	136-142	MALT1 paracaspase	Homo sapiens	98-103
17948050-7	2007	Multiple lysine residues in the C-terminus of Malt1 serve as acceptor sites for the assembly of polyubiquitin chains.	Lysine	9-15	MALT1 paracaspase	Homo sapiens	46-51
7991593-9	1994	A highly basic, lysine-rich motif of the predicted ELL protein is homologous to similar regions of several proteins, including the DNA-binding domain of poly(ADP-ribose) polymerase.	Lysine	16-22	elongation factor for RNA polymerase II	Homo sapiens	51-54
6280753-3	1982	The in vitro site of methylation by both the purified enzyme and crude wheat germ extract toward various forms of horse heart cytochrome c was localized by two dimensional peptide mapping, Aminex A-5 column peptide analysis, and CNBr cleavage analysis to be the residue 72 lysine.	Lysine	273-279	cytochrome c, somatic	Equus caballus	126-138
17948050-8	2007	Malt1 mutants that lack C-terminal ubiquitin acceptor lysines are impaired in rescuing NF-kappaB signaling and IL-2 production in Malt1-/- T cells.	Lysine	54-61	MALT1 paracaspase	Homo sapiens	0-5
17948050-8	2007	Malt1 mutants that lack C-terminal ubiquitin acceptor lysines are impaired in rescuing NF-kappaB signaling and IL-2 production in Malt1-/- T cells.	Lysine	54-61	MALT1 paracaspase	Homo sapiens	130-135
17932512-5	2007	Functional analyses in Drosophila show that the MBT domain of Scm and its methyl-lysine-binding activity are required for repression of Hox genes.	Lysine	81-87	tinman	Drosophila melanogaster	136-139
6262308-2	1981	The contribution of individual lysine amino groups to the electrostatic interaction was determined by measuring the reaction rate of specifically trifluoroacetylated or trifluoromethylphenylcarbamylated cytochrome c derivatives.	Lysine	31-37	cytochrome c, somatic	Equus caballus	203-215
6262308-3	1981	Modification of lysines 13, 27, 72, and 79 surrounding the heme crevice decreased the reaction rate by about 2-fold, while modification of lysine amino groups in other regions of cytochrome c had decreasing effects as the distance from the heme crevice was increased.	Lysine	16-23	cytochrome c, somatic	Equus caballus	179-191
6262308-3	1981	Modification of lysines 13, 27, 72, and 79 surrounding the heme crevice decreased the reaction rate by about 2-fold, while modification of lysine amino groups in other regions of cytochrome c had decreasing effects as the distance from the heme crevice was increased.	Lysine	16-22	cytochrome c, somatic	Equus caballus	179-191
6262308-4	1981	The interaction domain therefore involves specific complementary charge interactions between lysine amino groups immediately surrounding the heme crevice of cytochrome c and carboxylate groups on adrenodoxin.	Lysine	93-99	cytochrome c, somatic	Equus caballus	157-169
6262312-3	1981	A new semiempirical relationship for the electrostatic energy of interaction between cytochrome c and its oxidation-reduction partners was developed, in which specific complementary charge-pair interactions between lysine amino groups on cytochrome c and negatively charged carboxylate groups on the other protein are assumed to dominate the interaction.	Lysine	215-221	cytochrome c, somatic	Equus caballus	85-97
6262312-3	1981	A new semiempirical relationship for the electrostatic energy of interaction between cytochrome c and its oxidation-reduction partners was developed, in which specific complementary charge-pair interactions between lysine amino groups on cytochrome c and negatively charged carboxylate groups on the other protein are assumed to dominate the interaction.	Lysine	215-221	cytochrome c, somatic	Equus caballus	238-250
6262312-4	1981	The contribution of individual cytochrome c lysine amino groups to the electrostatic interaction was estimated from the decrease in reaction rate caused by specific modification of the lysine amino groups by reagents that change the charge to 0 or -1.	Lysine	44-50	cytochrome c, somatic	Equus caballus	31-43
6262312-4	1981	The contribution of individual cytochrome c lysine amino groups to the electrostatic interaction was estimated from the decrease in reaction rate caused by specific modification of the lysine amino groups by reagents that change the charge to 0 or -1.	Lysine	185-191	cytochrome c, somatic	Equus caballus	31-43
7998944-4	1994	In the first step, one of the unique kringle-IVs (K-IVs) in apo-a binds to a Lys residue of apoB; in the second step, Cys-4057 of K-IV type-9 (T-9) forms a disulphide bridge with Cys-3734 of LDL.	Lysine	77-80	lipoprotein(a)	Homo sapiens	60-65
7957235-4	1994	In contrast, a BDNF mutant with a single amino-acid replacement (Arg-1--&gt;Lys) in the basic processing site common to all neurotrophin precursors elutes as a single peak.	Lysine	76-79	arginase 1	Homo sapiens	65-70
6262312-5	1981	These estimates range from -0.9 kcal/mol for lysines immediately surrounding the heme crevice of cytochrome c to 0 kcal/mol for lysines well removed from the heme crevice region.	Lysine	45-52	cytochrome c, somatic	Equus caballus	97-109
17984618-0	2007	The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu &gt; Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.	Lysine	90-93	aldehyde dehydrogenase 2 family member	Homo sapiens	20-48
6262312-5	1981	These estimates range from -0.9 kcal/mol for lysines immediately surrounding the heme crevice of cytochrome c to 0 kcal/mol for lysines well removed from the heme crevice region.	Lysine	128-135	cytochrome c, somatic	Equus caballus	97-109
6783656-13	1981	As the changes in lysines 5 and 114 are similar to those observed in differential labeling, they are attributed to alterations in the affinity for galactosyltransferase resulting from acetylation of these groups.	Lysine	18-25	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	147-168
6783656-14	1981	In contrast, lysine 108, which is not sufficiently close to the interaction site to be perturbed in differential labeling studies but is greatly decreased in tritium content in the cross-linked complex, appears to represent the major site through which alpha-lactalbumin is cross-linked to galactosyltransferase as a result of the exclusion of protein molecules acetylated in this position from covalent cross-linking.	Lysine	13-19	lactalbumin alpha	Bos taurus	253-270
6783656-14	1981	In contrast, lysine 108, which is not sufficiently close to the interaction site to be perturbed in differential labeling studies but is greatly decreased in tritium content in the cross-linked complex, appears to represent the major site through which alpha-lactalbumin is cross-linked to galactosyltransferase as a result of the exclusion of protein molecules acetylated in this position from covalent cross-linking.	Lysine	13-19	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	290-311
7962321-2	1994	This mutation consists of deletion of three nucleotides (GAA) in exon 2 and results in loss of the lysine-121 in the putative ligand-binding domain of the alpha-subunit.	Lysine	99-105	alpha glucosidase	Homo sapiens	57-60
17984618-3	2007	A G-to-A missense mutation of ALDH2 gene, which causes a Glu &gt; Lys(504) substitution, was recently shown to be associated with carotid atherosclerosis; however, its relationship with coronary atherosclerosis has not been well studied.	Lysine	66-69	aldehyde dehydrogenase 2 family member	Homo sapiens	30-35
7925643-9	1994	Detachment was prevented by an anticatalytic anti-uPA antibody, by the plasmin-specific inhibitor aprotinin, and by the lysine analogue tranexamic acid, the latter of which prevents plasmin(ogen) binding to the cell surface.	Lysine	120-126	plasminogen	Homo sapiens	182-189
6783656-15	1981	Studies with a homologous series of bisimidoesters indicate that lysine 108 is situated 6.1 to 7.3 A degrees from an amino group on galactosyltransferase in the cross-linked complex.	Lysine	65-71	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	132-153
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Lysine	82-85	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
6457029-0	1981	Location of the nonidentical two reactive lysine residues in the myosin molecule.	Lysine	42-48	myosin heavy chain 14	Homo sapiens	65-71
7930635-3	1994	The conjugation is based on the principle that the succinimidyl ester group of m-ABS immediately acts on an epsilon-amino group of lysine residues of carrier protein BSA (or HSA) and a m-aminobenzoyl group incorporated into the protein is then activated by diazotization to a functional m-diazobenzoyl group (m-DB) acting on a histidyl group of TRH.	Lysine	131-137	thyrotropin releasing hormone	Rattus norvegicus	345-348
7925948-0	1994	Mutation of Lys-120 and Lys-134 drastically reduces the catalytic rate of Cu,Zn superoxide dismutase.	Lysine	12-15	superoxide dismutase [Cu-Zn]	Bos taurus	74-100
6257681-0	1981	Use of specific lysine modifications to identify the site of reaction between cytochrome c and ferricyanide.	Lysine	16-22	cytochrome c, somatic	Equus caballus	78-90
6257681-1	1981	The site of the reaction between horse heart ferrocytochrome c and ferricyanide was investigated by measuring the reaction rate of cytochrome c derivatives specifically modified at single lysine residues to form trifluoroacetyl or trifluoromethylphenylcarbamyl amino groups.	Lysine	188-194	cytochrome c, somatic	Equus caballus	50-62
6257681-2	1981	Cytochrome c derivatives singly modified at lysines 8, 13, 25, 27, 72, 79, and 87 surrounding the heme crevice had rate constants decreased from that of native cytochrome c by factors of 1.29, 2.03, 1.12, 1.35, 1.46, 1.29, and 1.19, respectively.	Lysine	44-51	cytochrome c, somatic	Equus caballus	0-12
6257681-5	1981	These results indicate that the reaction site is located at the exposed edge of the heme and that the electrostatic interaction between ferricyanide and cytochrome c is dominated by the lysine amino groups surrounding the heme crevice, which include lysine 86, in addition to the ones listed above.	Lysine	186-192	cytochrome c, somatic	Equus caballus	153-165
17675297-10	2007	In summary, this study not only demonstrates Pellino proteins to be E3 ligases that can catalyze Lys(63)-linked polyubiquitination but also shows bidirectional signaling between the IRAK and Pellino families and highlights a novel function for IRAK kinase activity.	Lysine	97-100	interleukin 1 receptor associated kinase 1	Homo sapiens	182-186
6257681-5	1981	These results indicate that the reaction site is located at the exposed edge of the heme and that the electrostatic interaction between ferricyanide and cytochrome c is dominated by the lysine amino groups surrounding the heme crevice, which include lysine 86, in addition to the ones listed above.	Lysine	250-256	cytochrome c, somatic	Equus caballus	153-165
6260144-4	1981	The faster rates of TNP-cytochrome c with the HiPIP"s are unexpected in terms of possible steric interaction since lysine-13 is at the top of the heme crevice.	Lysine	115-121	cytochrome c, somatic	Equus caballus	24-36
7925948-0	1994	Mutation of Lys-120 and Lys-134 drastically reduces the catalytic rate of Cu,Zn superoxide dismutase.	Lysine	24-27	superoxide dismutase [Cu-Zn]	Bos taurus	74-100
17675297-10	2007	In summary, this study not only demonstrates Pellino proteins to be E3 ligases that can catalyze Lys(63)-linked polyubiquitination but also shows bidirectional signaling between the IRAK and Pellino families and highlights a novel function for IRAK kinase activity.	Lysine	97-100	interleukin 1 receptor associated kinase 1	Homo sapiens	244-248
17850092-2	2007	Oxa-DAP is a substrate of DAP epimerase, a key enzyme for biosynthesis of l-lysine and formation of peptidoglycan precursors.	Lysine	74-82	death associated protein	Homo sapiens	4-7
7520754-2	1994	Lysine-217, located in the fourth hydrophilic domain of PLP, was found to be the major labeled residue, which defined this domain to be extracytoplasmic in agreement with our previously proposed topological model.	Lysine	0-6	proteolipid protein (myelin) 1	Mus musculus	56-59
8063713-5	1994	The first of these substrates, NFF-1 (Mca-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(Dnp)-Gly, where Mca is (7-methoxycoumarin-4-yl)acetyl and Dnp is 2,4-dinitrophenyl), was hydrolyzed equally well by MMP-3 and MMP-2 (kcat/Km approximately 11,000 s-1 M-1).	Lysine	46-49	matrix metallopeptidase 2	Homo sapiens	209-214
6803216-0	1981	Accessibility of epsilon-amino groups of lysine to guanidination in kappa-elastin from bovine ligamentum nuchae.	Lysine	41-47	elastin	Bos taurus	74-81
6160579-3	1980	The NH2 terminus was determined to be NH2-Met1-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-Gln-X-Gln-Lys.	Lysine	113-116	granzyme M	Homo sapiens	42-46
17850092-2	2007	Oxa-DAP is a substrate of DAP epimerase, a key enzyme for biosynthesis of l-lysine and formation of peptidoglycan precursors.	Lysine	74-82	death associated protein	Homo sapiens	26-29
17681943-3	2007	We demonstrate that mutating six surface-exposed lysine residues to arginine (6KR) to interfere with ubiquitin attachment can stabilize CK2beta.	Lysine	49-55	casein kinase 2 beta	Homo sapiens	136-143
6250589-0	1980	Use of specific trifluoroacetylation of lysine residues in cytochrome c to study the reaction with cytochrome b5, cytochrome c1, and cytochrome oxidase.	Lysine	40-46	cytochrome b5 type A	Homo sapiens	99-112
6250589-2	1980	The redox reaction rates of these derivatives with cytochrome b5, cytochrome c1 and cytochrome oxidase indicated that the interaction domain on cytochrome c for all three proteins involves the lysines immediately surrounding the heme crevice.	Lysine	193-200	cytochrome b5 type A	Homo sapiens	51-64
15299414-4	1994	In vitro, Tat binds through its basic domain (two Lys and six Arg in nine residues) to a three-nucleotide bulge of a stem-loop RNA structure called TAR.	Lysine	50-53	tyrosine aminotransferase	Homo sapiens	10-13
17805301-7	2007	Phosphorylated TORC2 was degraded by the 26S proteasome during re-feeding through an association with COP1, a substrate receptor for an E3 ligase complex that promoted TORC2 ubiquitination at Lys 628.	Lysine	192-195	CREB regulated transcription coactivator 2	Mus musculus	15-20
8024550-0	1994	Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.	Lysine	127-130	cytochrome P450 2B1	Rattus norvegicus	20-39
6254024-1	1980	The carbonate binding site on horse cytochrome c was mapped by comparing the yields of carboxydinitrophenyl-cytochromes c, each with a single carboxydinitrophenyl-substituted lysine residue per molecule, when the modification reaction was carried out in the presence and absence of carbonate.	Lysine	175-181	cytochrome c, somatic	Equus caballus	36-48
17805301-7	2007	Phosphorylated TORC2 was degraded by the 26S proteasome during re-feeding through an association with COP1, a substrate receptor for an E3 ligase complex that promoted TORC2 ubiquitination at Lys 628.	Lysine	192-195	CREB regulated transcription coactivator 2	Mus musculus	168-173
17693662-1	2007	Histone methyltransferase (HMT) enzymes that methylate the lysine of histones are involved in chromatin-mediated gene expression.	Lysine	59-65	PR/SET domain 9	Homo sapiens	0-25
7387627-2	1980	In addition, amino acid residues C-terminal to lysine residues in bovine tropoelastin were also examined.	Lysine	47-53	elastin	Bos taurus	73-85
7387627-4	1980	Apparently all the tyrosine residues C-terminal to lysine residues in pig tropoelastin are replaced with phenylalanine in bovine tropoelastin.	Lysine	51-57	elastin	Bos taurus	74-86
8069221-7	1994	The t-PAK2 structure also has noncrystallographic screw symmetry (3(1)) and mimics fibrin binding mode by having lysine of one molecule interacting electrostatically with the lysine binding site of another kringle.	Lysine	113-119	p21 (RAC1) activated kinase 2	Homo sapiens	6-10
8069221-7	1994	The t-PAK2 structure also has noncrystallographic screw symmetry (3(1)) and mimics fibrin binding mode by having lysine of one molecule interacting electrostatically with the lysine binding site of another kringle.	Lysine	175-181	p21 (RAC1) activated kinase 2	Homo sapiens	6-10
8069221-10	1994	Anions associate with the cationic centers of these and t-PAK2 that appear to be more than occasional components of lysine binding site regions.	Lysine	116-122	p21 (RAC1) activated kinase 2	Homo sapiens	58-62
8088314-2	1994	Recently Lp(a) was fractionated into two species with different affinities for Lysine-Sepharose.	Lysine	79-85	lipoprotein(a)	Homo sapiens	9-14
17693662-1	2007	Histone methyltransferase (HMT) enzymes that methylate the lysine of histones are involved in chromatin-mediated gene expression.	Lysine	59-65	PR/SET domain 9	Homo sapiens	27-30
158524-3	1979	The plasmin-streptokinase complex binds to Sepharose-lysine and Sepharose-fibrin monomer in the same fashion as free plasmin, showing that the lysine binding sites are fully exposed in the complex.	Lysine	53-59	plasminogen	Bos taurus	4-11
158524-3	1979	The plasmin-streptokinase complex binds to Sepharose-lysine and Sepharose-fibrin monomer in the same fashion as free plasmin, showing that the lysine binding sites are fully exposed in the complex.	Lysine	143-149	plasminogen	Bos taurus	4-11
17854661-2	2007	Recently, an isoleucine-lysine polymorphism at codon 1307 (I1307K) of the APC gene has been identified in 6-7% of the Ashkenazi Jewish population.	Lysine	24-30	APC regulator of WNT signaling pathway	Homo sapiens	74-77
158524-3	1979	The plasmin-streptokinase complex binds to Sepharose-lysine and Sepharose-fibrin monomer in the same fashion as free plasmin, showing that the lysine binding sites are fully exposed in the complex.	Lysine	143-149	plasminogen	Bos taurus	117-124
516595-2	1979	Net protein utilization (NPU) of the diet enriched by tryptophane, lysine or sulphur-containing amino acids comprised 0.408, 0.335 and 0.664.	Lysine	67-73	solute carrier family 6 member 2	Rattus norvegicus	0-3
8088314-3	1994	The influence of lysine-binding heterogeneity of Lp(a) on its cardiovascular pathogenicity has not previously been studied.	Lysine	17-23	lipoprotein(a)	Homo sapiens	49-54
8088314-8	1994	Similar results were obtained when the same analysis was carried out for [lys+] and [lys-] species of Lp(a) (odds ratio 11.52 and 3.3, respectively; chi-square 12.3 and 4.34, respectively; P = 0.0004 and 0.037, respectively).	Lysine	47-50	lipoprotein(a)	Homo sapiens	102-107
8088314-8	1994	Similar results were obtained when the same analysis was carried out for [lys+] and [lys-] species of Lp(a) (odds ratio 11.52 and 3.3, respectively; chi-square 12.3 and 4.34, respectively; P = 0.0004 and 0.037, respectively).	Lysine	74-77	lipoprotein(a)	Homo sapiens	102-107
17938767-7	2007	TAFIa, the product of TAFI activation, removes lysine residues from fibrin, which are essential for the binding of t-PA, plasminogen, and plasmin to fibrin.	Lysine	47-53	carboxypeptidase B2	Homo sapiens	0-4
8182131-11	1994	G6Pase is an endoplasmic reticulum (ER) membrane-associated protein containing an ER retention signal, two lysines (KK), located at residues 354 and 355.	Lysine	107-114	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-6
8182131-12	1994	We showed that the G6Pase-K355SP mutant containing a lysine-355 to stop codon mutation is enzymatically active.	Lysine	53-59	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	19-25
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	24-30	E1A binding protein p300	Homo sapiens	129-133
481679-6	1979	The stabilizing effect is most pronounced for GABA, although some amino acids such as asparagine, glutamine, and lysine as well as some GABA analogues and homologues also tend to increase ODC but to a significantly lesser extent than GABA itself.	Lysine	113-119	ornithine decarboxylase 1	Rattus norvegicus	188-191
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	24-30	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	57-60	E1A binding protein p300	Homo sapiens	129-133
7511144-8	1994	The binding of 125I-Pg was associated with lysine binding sites of the plasminogen molecule.	Lysine	43-49	plasminogen	Homo sapiens	71-82
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	57-60	lysine acetyltransferase 2B	Homo sapiens	138-142
7511144-14	1994	Plasmin activated on the cell surface was partially protected from inhibition by alpha 2-antiPm (requiring Pm lysine binding site interaction) but inhibited by aprotinin, (interacting directly with the Pm catalytic site).	Lysine	110-116	plasminogen	Homo sapiens	0-7
223955-6	1979	Since the imidoester groups on the surface of the resin carrier cannot react with buried lysine residues, this method gives strong chemical evidence for the spreading of the apo AII polypeptide chain over the surface of the lipoprotein particle, as far as the sequence carrying lysine residues between residue 22 and 55 of each symmetrical half is concerned.	Lysine	278-284	apolipoprotein A2	Homo sapiens	174-181
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	E1A binding protein p300	Homo sapiens	129-133
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	E1A binding protein p300	Homo sapiens	129-133
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
373354-1	1978	Cathepsin B, purified from isolated islets of Langerhans, when incubated with proinsulin under in vitro conditions could convert proinsulin to insulin and C-peptide, releasing free arginine and lysine.	Lysine	194-200	cathepsin B	Rattus norvegicus	0-11
8177211-8	1994	The predicted RSI-1 protein is rich in cysteine, lysine and proline, and includes an N-terminal region with characteristics of a signal peptide.	Lysine	49-55	protein RSI-1	Solanum lycopersicum	14-19
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	E1A binding protein p300	Homo sapiens	129-133
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	E1A binding protein p300	Homo sapiens	129-133
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	166-169	E1A binding protein p300	Homo sapiens	37-41
7914520-2	1994	Human elafin, a potent inhibitor specific for elastase and proteinase 3, has a unique repeating sequence in its prosegment that is rich in Gln and Lys residues.	Lysine	147-150	peptidase inhibitor 3	Homo sapiens	6-12
7914520-2	1994	Human elafin, a potent inhibitor specific for elastase and proteinase 3, has a unique repeating sequence in its prosegment that is rich in Gln and Lys residues.	Lysine	147-150	proteinase 3	Homo sapiens	46-71
8117273-2	1994	Using a fluorogenic substrate Ac-Lys-Thr-Lys-Gln-Leu-Arg-MCA corresponding to the sequence around the cleavage site of pro-HGF, HGF-converting enzyme was purified from fetal bovine serum.	Lysine	33-36	hepatocyte growth factor	Homo sapiens	128-131
649256-3	1978	A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease.	Lysine	116-119	ribonuclease A family member 1, pancreatic	Rattus norvegicus	226-249
649256-3	1978	A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease.	Lysine	124-127	ribonuclease A family member 1, pancreatic	Rattus norvegicus	226-249
649256-3	1978	A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease.	Lysine	124-127	ribonuclease A family member 1, pancreatic	Rattus norvegicus	226-249
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	166-169	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	166-169	E1A binding protein p300	Homo sapiens	127-131
415884-4	1977	Also, the responses to other GL-containing polymers, such as poly-L (Glu, Lys, Ala) and poly-L (Glu, Lys, Pro), which are under the control of distinct Ir genes, can stimulate the production of GL-binding antibodies that share common BGL idiotypic determinants with antibodies induced with GLphi.	Lysine	74-77	galactosidase, beta 1	Mus musculus	234-237
415884-4	1977	Also, the responses to other GL-containing polymers, such as poly-L (Glu, Lys, Ala) and poly-L (Glu, Lys, Pro), which are under the control of distinct Ir genes, can stimulate the production of GL-binding antibodies that share common BGL idiotypic determinants with antibodies induced with GLphi.	Lysine	101-104	galactosidase, beta 1	Mus musculus	234-237
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	166-169	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
199233-0	1977	Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5.	Lysine	50-57	cytochrome b5 type A	Homo sapiens	79-92
8117273-2	1994	Using a fluorogenic substrate Ac-Lys-Thr-Lys-Gln-Leu-Arg-MCA corresponding to the sequence around the cleavage site of pro-HGF, HGF-converting enzyme was purified from fetal bovine serum.	Lysine	41-44	hepatocyte growth factor	Homo sapiens	128-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
562863-3	1977	This paper deals with the effect in vitro of flavonoids and flavonoid-copper complexes on the oxidative deamination of lysine epsilon-amino groups in [4,5-3H]-lysine-labelled elastin.	Lysine	119-125	elastin	Mus musculus	175-182
8307974-4	1994	The three-dimensional crystal structure of the histidine-binding protein complexed with histidine has been determined at 2.5-A resolution by the molecular replacement method using a probe structure the previously solved lysine-liganded structure of the lysine-, arginine-, ornithine-binding protein (LAO), which shares 70% sequence identity with HisJ.	Lysine	220-226	interleukin 4 induced 1	Homo sapiens	253-298
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
8307974-8	1994	The HisJ residues surrounding the ligand are the same as the LAO residues interacting with lysine, except for residue 52 which is leucine in HisJ and phenylalanine in LAO.	Lysine	91-97	interleukin 4 induced 1	Homo sapiens	61-64
562863-3	1977	This paper deals with the effect in vitro of flavonoids and flavonoid-copper complexes on the oxidative deamination of lysine epsilon-amino groups in [4,5-3H]-lysine-labelled elastin.	Lysine	159-165	elastin	Mus musculus	175-182
562863-5	1977	The lysine epsilon-amino groups of elastin are specifically concerned: in fact no effect was observed on free [4,5-3H]-lysine or on [4,5-3H]-lysine-labelled proteins obtained from mouse liver.	Lysine	4-10	elastin	Mus musculus	35-42
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
196686-4	1977	The purified enzyme displays high specificity for the lysine-rich histones (H1, H2b, H2a).	Lysine	54-60	H2B clustered histone 21	Homo sapiens	80-83
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
8262986-10	1993	This serous cell lysozyme is predicted to differ importantly in structure from both 7a and 14d lysozymes, with an arginine:lysine ratio almost 10-fold higher.	Lysine	123-129	lysozyme C, tracheal isozyme	Bos taurus	17-25
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
861226-3	1977	For lysine-rich histones (H1 and H2B) it has been found that the main characteristics which governs the interaction with DNA are located in the very lysine-rich part of the molecules, i.e. in the C-H1 and N-H2B segments.	Lysine	4-10	H2B clustered histone 21	Homo sapiens	33-36
861226-3	1977	For lysine-rich histones (H1 and H2B) it has been found that the main characteristics which governs the interaction with DNA are located in the very lysine-rich part of the molecules, i.e. in the C-H1 and N-H2B segments.	Lysine	4-10	SUN domain containing ossification factor	Homo sapiens	196-210
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
861226-3	1977	For lysine-rich histones (H1 and H2B) it has been found that the main characteristics which governs the interaction with DNA are located in the very lysine-rich part of the molecules, i.e. in the C-H1 and N-H2B segments.	Lysine	149-155	H2B clustered histone 21	Homo sapiens	33-36
861226-3	1977	For lysine-rich histones (H1 and H2B) it has been found that the main characteristics which governs the interaction with DNA are located in the very lysine-rich part of the molecules, i.e. in the C-H1 and N-H2B segments.	Lysine	149-155	SUN domain containing ossification factor	Homo sapiens	196-210
8227051-1	1993	Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-.	Lysine	148-151	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
8227054-3	1993	Specifically, TrfA proteins with deletions or substitutions of the terminal cysteine, lysine, and arginine (codons 380-382, respectively) were constructed and characterized for their ability to initiate replication from an RK2 origin in vivo in E. coli, Azotobacter vinelandii, Pseudomonas putida, and Agrobacterium tumefaciens and for binding activity to the iterons at the replication origin.	Lysine	86-92	TrfA-like protein	Escherichia coli	14-18
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
8109742-1	1993	Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HL) were biotinylated using N-hydroxysuccinamide ester of biotin (25-fold molar excess) which was incorporated into the lysine amino groups of the enzyme protein.	Lysine	178-184	lipoprotein lipase	Bos taurus	0-18
197035-3	1977	A solution synthesis of Z-Gly-Thr-Lys (Tfa)-Met-Ile-Phe-Ala-Gly-Ile-Lys (Tfa)-Lys (Tfa)-NHNH-Boc corresponding to the sequence 77-87 of horse heart cytochrome c is described.	Lysine	68-71	cytochrome c, somatic	Equus caballus	148-160
197036-3	1977	A solution synthesis is described of the partially protected N alpha-benzyloxycarbonylheptadecapeptide Z-Lys (Tfa)-Thr-Glu-Arg-Glu-Asp-Leu-Ile-Ala-Tyr-Leu-Lys (Tfa)-Lys (Tfa)-Ala-Thr-Asn-Glu (OBu t)-OBu t corresponding to sequence 88-104 of horse heart cytochrome c.	Lysine	105-108	cytochrome c, somatic	Equus caballus	253-265
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
1115799-3	1975	They are hemoglobin Alabama (beta 39(C 5)Gln leads to Lys) and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg).	Lysine	54-57	complement C5	Homo sapiens	9-40
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	127-131
8244629-7	1993	Hydrophobic substitutions Leu and D-Trp at positions 11 (Lys) and 12 (Gly), respectively, in PTHrP-(7-34)NH2 resulted in increased potency, but the derivatives were not significantly more helical than the unsubstituted peptide in the presence of surfactants.	Lysine	57-60	parathyroid hormone like hormone	Homo sapiens	93-98
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	E1A binding protein p300	Homo sapiens	37-41
4374411-7	1974	Similarly, lysine replacements occurred almost exclusively in the NA-induced revertants of only the ochre mutant cyc1-72, but not at all in the others.	Lysine	11-17	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	113-117
8360181-6	1993	Solution phase fibronectin binding to immobilized plasminogen was mediated primarily via lysine binding site-dependent interactions with plasminogen kringles 1-4.	Lysine	89-95	plasminogen	Homo sapiens	50-61
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 &gt; Lys-66 &gt; Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 &gt; Lys-64 approximately Lys-66 &gt; Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
8360181-6	1993	Solution phase fibronectin binding to immobilized plasminogen was mediated primarily via lysine binding site-dependent interactions with plasminogen kringles 1-4.	Lysine	89-95	plasminogen	Homo sapiens	137-148
17691833-7	2007	Analogous modifications and an additional methylation of Lys-3 were identified for HTB11.	Lysine	57-60	Histone superfamily protein	Arabidopsis thaliana	83-88
8360181-7	1993	Lysine binding site-dependent binding of soluble laminin to immobilized plasminogen kringles 1-5 as well as an additional lysine binding site-independent interaction between mini-plasminogen and the 38-kDa laminin A chain fragment were also observed.	Lysine	0-6	plasminogen	Homo sapiens	72-83
8360181-7	1993	Lysine binding site-dependent binding of soluble laminin to immobilized plasminogen kringles 1-5 as well as an additional lysine binding site-independent interaction between mini-plasminogen and the 38-kDa laminin A chain fragment were also observed.	Lysine	122-128	plasminogen	Homo sapiens	179-190
4850239-0	1974	A new delta chain variant, haemoglobin-A2-Melbourne or alpha2 delta2 43Glu-Lys(CD2).	Lysine	75-78	CD2 molecule	Homo sapiens	79-82
17310991-4	2007	Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into BEAS-2B human bronchial epithelial (HBE) cells to evaluate stabilities after all-trans-retinoic acid (RA) or cycloheximide treatments.	Lysine	9-16	cyclin D1	Homo sapiens	20-29
5580564-0	1971	[Activation of lysine and aminoacylation of tRNA under the effect of lysyl-tRNA-synthetase from liver of rats subjected to whole-body roentgen irradiation].	Lysine	15-21	lysyl-tRNA synthetase 1	Rattus norvegicus	69-90
8344522-4	1993	The predicted DnaK sequence has a high Lys:Arg ratio which is not typical of streptomycete proteins.	Lysine	39-42	dnaK	Streptomyces coelicolor A3(2)	14-18
8344203-2	1993	Furin cleaves the concensus processing site -Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1-.	Lysine	55-58	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
17310991-5	2007	Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life.	Lysine	68-75	cyclin D1	Homo sapiens	30-39
8513967-4	1993	The amino acid analysis of untreated and glyceraldehyde-treated glucokinase suggested that glyceraldehyde-induced inactivation of glucokinase is caused by glycation of Lys residues of the enzyme by the triose.	Lysine	168-171	glucokinase	Rattus norvegicus	64-75
4917529-0	1970	Lysine as substrate for ornithine carbamoyltransferase.	Lysine	0-6	ornithine transcarbamylase	Homo sapiens	24-54
17310991-5	2007	Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life.	Lysine	68-75	cyclin D1	Homo sapiens	166-175
17310991-6	2007	Mutation of all cyclin D1 lysines blocked polyubiquitination.	Lysine	26-33	cyclin D1	Homo sapiens	16-25
17690487-3	2007	Thrombin activatable fibrinolysis inhibitor (TAFI) is a novel plasma protein, which inhibits fibrinolysis through removal of C-terminal lysines from partially degraded fibrin.	Lysine	136-143	carboxypeptidase B2	Homo sapiens	0-43
33774829-8	2021	The SUMO-interacting motifs (SIMs) LVIVF, VIWV, and a lysine residue at position 78 (K78) are required for the ORF4 protein SUMOylation.	Lysine	54-60	cortactin binding protein 2	Homo sapiens	111-115
8513967-4	1993	The amino acid analysis of untreated and glyceraldehyde-treated glucokinase suggested that glyceraldehyde-induced inactivation of glucokinase is caused by glycation of Lys residues of the enzyme by the triose.	Lysine	168-171	glucokinase	Rattus norvegicus	130-141
17690487-3	2007	Thrombin activatable fibrinolysis inhibitor (TAFI) is a novel plasma protein, which inhibits fibrinolysis through removal of C-terminal lysines from partially degraded fibrin.	Lysine	136-143	carboxypeptidase B2	Homo sapiens	45-49
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Lysine	46-49	SLC9A3 regulator 1	Homo sapiens	128-133
8504104-4	1993	In the other, lysine-69, the pyridoxal 5"-phosphate (PLP, the cofactor of ODC) binding residue was converted to alanine.	Lysine	14-20	pyridoxal phosphatase	Homo sapiens	53-56
8504104-4	1993	In the other, lysine-69, the pyridoxal 5"-phosphate (PLP, the cofactor of ODC) binding residue was converted to alanine.	Lysine	14-20	ornithine decarboxylase 1	Homo sapiens	74-77
8504104-9	1993	We therefore conclude that the active site of ODC is formed at the interface of the two monomers through the interaction of the cysteine-360-containing region of one monomer subunit with the region that contains lysine-69 of the other subunit.	Lysine	212-218	ornithine decarboxylase 1	Homo sapiens	46-49
34000466-2	2021	Here, we report that aspirin attenuates the glycolysis and proliferation of hepatoma cells through modulating the levels of lysine 2-hydroxyisobutyrylation (Khib) of enolase 1 (ENO1).	Lysine	124-130	enolase 1	Homo sapiens	166-175
34000466-2	2021	Here, we report that aspirin attenuates the glycolysis and proliferation of hepatoma cells through modulating the levels of lysine 2-hydroxyisobutyrylation (Khib) of enolase 1 (ENO1).	Lysine	124-130	enolase 1	Homo sapiens	177-181
8387333-8	1993	The ligand-binding site of one apo[a] kringle model is almost identical to that of PGK4 and may be a lysine-binding site of apo[a].	Lysine	101-107	lipoprotein(a)	Homo sapiens	31-36
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Lysine	46-49	SLC9A3 regulator 1	Homo sapiens	134-139
8387333-8	1993	The ligand-binding site of one apo[a] kringle model is almost identical to that of PGK4 and may be a lysine-binding site of apo[a].	Lysine	101-107	lipoprotein(a)	Homo sapiens	124-129
8387333-9	1993	Four other apo[a] kringle models appear to have structurally similar lysine-binding sites, but with differences that may influence ligand-polypeptide specificity.	Lysine	69-75	lipoprotein(a)	Homo sapiens	11-16
34047687-6	2022	Finally, nicotine increased the expression of Kdm4c, a key histone lysine demethylase, and decreased Suv39h1, a critical histone lysine methyltransferase.	Lysine	129-135	SUV39H1 histone lysine methyltransferase	Rattus norvegicus	101-108
17562855-0	2007	SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes.	Lysine	41-47	lysine methyltransferase 5A	Homo sapiens	0-4
34039738-4	2021	Tau-mediated toxicity in postsynaptic compartments was exacerbated by impaired proteasome activity detected by measuring lysine-48 polyubiquitination of proteins targeted for proteasomal degradation.	Lysine	121-127	microtubule associated protein tau	Homo sapiens	0-3
8383426-5	1993	Induction of the early phase of plasmin"s effect required both the lysine binding and catalytic sites in plasmin molecule because it was inhibited either by the binding antagonist tranexamic acid or by the serine protease inhibitor aprotinin.	Lysine	67-73	plasminogen	Homo sapiens	32-39
17478422-7	2007	At least three lysine residues, Lys(19), Lys(20), and Lys(39), are required for efficient acetylation of Smad2, as mutations altering these lysines abolished Smad2 acetylation in vivo.	Lysine	15-21	SMAD family member 2	Homo sapiens	105-110
1360664-6	1992	The sequence, corresponding to residues 165-174 of alpha B-crystallin, unambiguously identifies the known carboxyl-terminal domain, EK-PAVTAAPKK, as the prominent lysine-donating fragment in bovine lens.	Lysine	163-169	crystallin alpha B	Bos taurus	51-69
34031939-11	2021	Downregulation of KLF14 in activated HSCs was mediated by EZH2-regulated histone H3 lysine 27 trimethylation.	Lysine	84-90	Kruppel-like factor 14	Mus musculus	18-23
17478422-7	2007	At least three lysine residues, Lys(19), Lys(20), and Lys(39), are required for efficient acetylation of Smad2, as mutations altering these lysines abolished Smad2 acetylation in vivo.	Lysine	32-35	SMAD family member 2	Homo sapiens	105-110
34052673-2	2021	Alpha Tubulin Acetyltransferase 1 (ATAT1) is a major enzyme that acetylates "Lys-40" in alpha-tubulin on the luminal side of microtubules and is a drug target that lacks inhibitors.	Lysine	77-80	alpha tubulin acetyltransferase 1	Homo sapiens	0-33
17478422-7	2007	At least three lysine residues, Lys(19), Lys(20), and Lys(39), are required for efficient acetylation of Smad2, as mutations altering these lysines abolished Smad2 acetylation in vivo.	Lysine	41-44	SMAD family member 2	Homo sapiens	105-110
34052673-2	2021	Alpha Tubulin Acetyltransferase 1 (ATAT1) is a major enzyme that acetylates "Lys-40" in alpha-tubulin on the luminal side of microtubules and is a drug target that lacks inhibitors.	Lysine	77-80	alpha tubulin acetyltransferase 1	Homo sapiens	35-40
34052673-2	2021	Alpha Tubulin Acetyltransferase 1 (ATAT1) is a major enzyme that acetylates "Lys-40" in alpha-tubulin on the luminal side of microtubules and is a drug target that lacks inhibitors.	Lysine	77-80	tubulin alpha 1b	Homo sapiens	88-101
1360148-2	1992	Fusion activity requires proteolytic cleavage of the gp160 protein into gp120 and gp41 at a site containing several arginine and lysine residues.	Lysine	129-135	glutamyl aminopeptidase	Homo sapiens	53-58
1360148-5	1992	Furin, a subtilisin-like eukaryotic endoprotease, has a substrate specificity for the consensus amino-acid sequence Arg-X-Lys/Arg-Arg at the cleavage site.	Lysine	122-125	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-48
17478422-7	2007	At least three lysine residues, Lys(19), Lys(20), and Lys(39), are required for efficient acetylation of Smad2, as mutations altering these lysines abolished Smad2 acetylation in vivo.	Lysine	41-44	SMAD family member 2	Homo sapiens	105-110
17478422-7	2007	At least three lysine residues, Lys(19), Lys(20), and Lys(39), are required for efficient acetylation of Smad2, as mutations altering these lysines abolished Smad2 acetylation in vivo.	Lysine	140-147	SMAD family member 2	Homo sapiens	105-110
34029587-4	2021	Type I PRMT inhibitor (MS023) or substitution of R95 or R177 with lysine inhibited interaction of N protein with the 5"-UTR of SARS-CoV-2 genomic RNA, a property required for viral packaging.	Lysine	66-72	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	98-99
17579744-1	2007	N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.	Lysine	151-157	afamin	Homo sapiens	410-413
33929180-1	2021	Editing of the pre-mRNA of the DNA repair glycosylase NEIL1 results in substitution of a Lys with Arg in the lesion recognition loop of the enzyme.	Lysine	89-92	nei like DNA glycosylase 1	Homo sapiens	54-59
17570828-2	2007	Using biospecific interaction analysis, both Glu- and Lys-Plg were shown to interact with immobilized sMTf.	Lysine	54-57	plasminogen	Homo sapiens	58-61
34006303-10	2021	Mechanistically, KDM6A promotes the transcription of ARHGDIB by demethylating histone H3 lysine di/trimethylation (H3K27me2/3) and consequently leads to inhibition of Rac1.	Lysine	89-95	lysine (K)-specific demethylase 6A	Mus musculus	17-22
34006870-5	2021	PLK1 transcript levels are shown to be regulated by an unmutated lysine methyl-transferase (KMT2A) resulting in increased promoter monomethylation of lysine 4 of histone 3.	Lysine	150-156	lysine methyltransferase 2A	Homo sapiens	92-97
1321590-0	1992	Presence of an essential lysine residue in a GDP-fucose protected site of the alpha 1----3fucosyltransferase from human small cell lung carcinoma NCl-H69 cells.	Lysine	25-31	nucleolin	Homo sapiens	146-149
1420981-6	1992	We have synthesized an anionic melittin analogue of MLT (E-MLT; net charge -4) in which all five lysine and arginine residues are replaced with glutamate, and acetyl and succinyl derivatives of E-MLT (net charges -5 and -6).	Lysine	97-103	MALT1 paracaspase	Homo sapiens	52-55
17570828-4	2007	In addition, in the presence of Lys-Plg, the internalization of sMTf was a saturable process, sensitive to temperature and dependent on the integrity of lysine residues.	Lysine	32-35	plasminogen	Homo sapiens	36-39
17570828-4	2007	In addition, in the presence of Lys-Plg, the internalization of sMTf was a saturable process, sensitive to temperature and dependent on the integrity of lysine residues.	Lysine	153-159	plasminogen	Homo sapiens	36-39
1376317-6	1992	Binding of Lys-plasminogen and active-site-blocked plasmin was at least 10-fold higher in affinity (KD = 85-100 nM) compared to Glu-plasminogen (KD approximately 1 microM) and could be inhibited by lysine analogs but not by glycosaminoglycans or PAI-1, indicating that heteropolar plasmin(ogen) binding of VN occurs to an adjacent segment upstream to the heparin and PAI-1-binding sites.	Lysine	198-204	plasminogen	Homo sapiens	15-22
33639104-1	2021	Dihydrodipicolinate synthase (DHDPS) catalyzes the first step in the biosynthetic pathway for production of l-lysine in bacteria and plants.	Lysine	108-116	dihydrodipicolinate synthase	Escherichia coli	0-28
1376317-6	1992	Binding of Lys-plasminogen and active-site-blocked plasmin was at least 10-fold higher in affinity (KD = 85-100 nM) compared to Glu-plasminogen (KD approximately 1 microM) and could be inhibited by lysine analogs but not by glycosaminoglycans or PAI-1, indicating that heteropolar plasmin(ogen) binding of VN occurs to an adjacent segment upstream to the heparin and PAI-1-binding sites.	Lysine	198-204	plasminogen	Homo sapiens	51-58
17489985-4	2007	Both ADH2 Arg/Arg and ALDH2 Glu/Lys were found to be independently associated with increased risk, with odds ratios (OR) of 2.67 (95% confidence interval [CI] 1.51-4.57) and 1.66 (95% CI 1.20-2.31), respectively.	Lysine	32-35	aldehyde dehydrogenase 2 family member	Homo sapiens	22-27
17561960-12	2007	Mutation of the Walker A lysine in nucleotide-binding domain 1 (K719A) or nucleotide-binding domain 2 (K1385M) inhibited the ATPase activity of sulfonylurea receptor 1 by 60% and 80%, respectively.	Lysine	25-31	dynein axonemal heavy chain 8	Homo sapiens	125-131
1375508-2	1992	alpha-N-acetyl-L-lysine methyl ester (NALME) is a lysine analogue that reportedly binds to low-affinity lysine binding sites in plasmin(ogen) and miniplasmin(ogen).	Lysine	17-23	plasminogen	Homo sapiens	128-135
1375508-2	1992	alpha-N-acetyl-L-lysine methyl ester (NALME) is a lysine analogue that reportedly binds to low-affinity lysine binding sites in plasmin(ogen) and miniplasmin(ogen).	Lysine	50-56	plasminogen	Homo sapiens	128-135
33986343-3	2021	We show that Rab12 interacts with RILP, RILP-L1 and RILP-L2 independently of each other, whereby lysine-71, in mouse Rab12, is critical for Rab12 interactions with RILP-L1 or RILP-L2, but is dispensable for the binding of RILP.	Lysine	97-103	RAB12, member RAS oncogene family	Mus musculus	117-122
33986343-3	2021	We show that Rab12 interacts with RILP, RILP-L1 and RILP-L2 independently of each other, whereby lysine-71, in mouse Rab12, is critical for Rab12 interactions with RILP-L1 or RILP-L2, but is dispensable for the binding of RILP.	Lysine	97-103	RAB12, member RAS oncogene family	Mus musculus	117-122
17561960-12	2007	Mutation of the Walker A lysine in nucleotide-binding domain 1 (K719A) or nucleotide-binding domain 2 (K1385M) inhibited the ATPase activity of sulfonylurea receptor 1 by 60% and 80%, respectively.	Lysine	25-31	ATP binding cassette subfamily C member 8	Homo sapiens	144-167
17439941-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	NEDD8 ubiquitin like modifier	Homo sapiens	153-158
33303977-1	2021	Histone lysine demethylase 6a (Kdm6a) mediates the removal of repressive trimethylation from histone H3 lysine 27 (H3K27me3) to activate target gene expression.	Lysine	8-14	lysine (K)-specific demethylase 6A	Mus musculus	31-36
1394685-1	1992	Poly-L-lysine with molecular masses of 3.3-290 kDa increased the amidolytic activities of leukocyte elastase and cathepsin G at low concentration, but had little effect on the activities of pancreatic elastase, alpha-chymotrypsin, plasmin and thrombin.	Lysine	0-13	elastase, neutrophil expressed	Homo sapiens	90-108
17535915-4	2007	Here we show that B23 is sumoylated on both Lysine 230 and 263 residues, but the latter is the major one.	Lysine	44-50	nucleophosmin 1	Homo sapiens	18-21
1530364-1	1992	An enzyme preparation with affinity to a lysine column was detected from a DEAE-cellulose-adsorbed preparation of human seminal plasma containing plasminogen and plasmin.	Lysine	41-47	plasminogen	Homo sapiens	146-153
33723435-4	2021	Dimethylation of lysine 79 of histone H3 (H3K79me2) and the enzymes (DOT1L and KDM2B) that control this modification are enriched in D2-type medium spiny neurons and are shown to be crucial for the expression of ELS-induced stress susceptibility.	Lysine	17-23	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	69-74
33907746-3	2021	Here we reported that SUPT16H, a subunit of FACT, is acetylated at lysine 674 (K674) of middle domain (MD), which involves TIP60 histone acetyltransferase.	Lysine	67-73	SPT16 homolog, facilitates chromatin remodeling subunit	Homo sapiens	22-29
1521731-2	1992	The variant sequences Val-Met985 and Lys-Glu1068 of the insulin receptor and Val-Ile383 of GLUT 4 were each separately found in three different diabetic subjects.	Lysine	37-40	insulin receptor	Homo sapiens	56-72
17485541-6	2007	Alanine substitutions for lysines 408 and 412 (K408A/K412A) in a putative nucleotide-binding site of muA abolished NTPase activity, further suggesting that NTPase activity is attributable to protein muA.	Lysine	26-33	mu-A protein	Avian orthoreovirus	101-104
1533399-0	1992	Plasmin generation induces neutrophil aggregation: dependence on the catalytic and lysine binding sites.	Lysine	83-89	plasminogen	Homo sapiens	0-7
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Lysine	78-81	SAFB like transcription modulator	Homo sapiens	138-141
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Lysine	78-81	SAFB like transcription modulator	Homo sapiens	153-156
1533399-7	1992	Pretreatment of PMN with either active-site-inhibited plasmin or tranexamic acid prevented PMN aggregation by plasmin, indicating that both binding of plasmin to the cell surface via the lysine binding sites and catalysis were required for the response.	Lysine	187-193	plasminogen	Homo sapiens	54-61
33852845-3	2021	Spermidine serves as the amino-butyl group donor for the synthesis of hypusine (Nepsilon-[4-amino-2-hydroxybutyl]-lysine) at a specific lysine residue of the eukaryotic translation initiation factor 5A (eIF5A).	Lysine	114-120	eukaryotic translation elongation factor 5	Drosophila melanogaster	158-201
1533399-7	1992	Pretreatment of PMN with either active-site-inhibited plasmin or tranexamic acid prevented PMN aggregation by plasmin, indicating that both binding of plasmin to the cell surface via the lysine binding sites and catalysis were required for the response.	Lysine	187-193	plasminogen	Homo sapiens	110-117
17485541-6	2007	Alanine substitutions for lysines 408 and 412 (K408A/K412A) in a putative nucleotide-binding site of muA abolished NTPase activity, further suggesting that NTPase activity is attributable to protein muA.	Lysine	26-33	mu-A protein	Avian orthoreovirus	199-202
1533399-7	1992	Pretreatment of PMN with either active-site-inhibited plasmin or tranexamic acid prevented PMN aggregation by plasmin, indicating that both binding of plasmin to the cell surface via the lysine binding sites and catalysis were required for the response.	Lysine	187-193	plasminogen	Homo sapiens	110-117
33852845-3	2021	Spermidine serves as the amino-butyl group donor for the synthesis of hypusine (Nepsilon-[4-amino-2-hydroxybutyl]-lysine) at a specific lysine residue of the eukaryotic translation initiation factor 5A (eIF5A).	Lysine	114-120	eukaryotic translation elongation factor 5	Drosophila melanogaster	203-208
17289364-8	2007	Hydroxylation of the telopeptide lysines by LH2 thus occurs only in the context of a long peptide.	Lysine	33-40	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	44-47
33631678-0	2021	Lysine 72 substitutions differently affect lipid membrane permeabilizing and proapoptotic activities of horse heart cytochrome c.	Lysine	0-6	cytochrome c, somatic	Equus caballus	116-128
1532491-9	1992	The present findings suggest that the ability of oleic acid to stimulate plasmin activity and to enhance the conversion of plasminogen to plasmin depends on the interaction of oleic acid with specific lysine-binding sites in plasmin.	Lysine	201-207	plasminogen	Homo sapiens	73-80
1532491-9	1992	The present findings suggest that the ability of oleic acid to stimulate plasmin activity and to enhance the conversion of plasminogen to plasmin depends on the interaction of oleic acid with specific lysine-binding sites in plasmin.	Lysine	201-207	plasminogen	Homo sapiens	123-130
1532491-9	1992	The present findings suggest that the ability of oleic acid to stimulate plasmin activity and to enhance the conversion of plasminogen to plasmin depends on the interaction of oleic acid with specific lysine-binding sites in plasmin.	Lysine	201-207	plasminogen	Homo sapiens	123-130
33827814-3	2021	Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.	Lysine	113-119	forkhead box A1	Homo sapiens	16-21
33827814-3	2021	Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.	Lysine	113-119	forkhead box A1	Homo sapiens	104-109
17374603-3	2007	To elucidate the roles self-associated GATA-1 plays during hematopoietic cell development in vivo, in this study we prepared GATA-1 mutants in which three lysine residues potentially contributing to the self-association (Lys-245, Lys-246, and Lys-312) are substituted in combination with alanines.	Lysine	221-224	GATA binding protein 1	Mus musculus	39-45
33693809-2	2021	METTL18 is the last uncharacterized member of a group of human methyltransferases (MTases) that mainly exert lysine methylation, and here we set out to elucidate its function.	Lysine	109-115	methyltransferase like 18	Homo sapiens	0-7
1476544-0	1992	2",3"-O-(2,4,6-trinitrophenyl)-8-azido-AMP and -ATP photolabel Lys-492 at the active site of sarcoplasmic reticulum Ca(2+)-ATPase.	Lysine	63-66	dynein axonemal heavy chain 8	Homo sapiens	123-129
17452628-7	2007	This phenotype of the S103P mutation required a cluster of positively charged amino acid residues (Arg or Lys) located close to the mutation site in the Ire1 sequence.	Lysine	106-109	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	153-157
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Lysine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
1587790-7	1992	These observations support the notion that furin is the endogenous endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Lysine	120-123	furin, paired basic amino acid cleaving enzyme	Homo sapiens	43-48
32764680-4	2021	Here we investigate the essentiality of lysine acetyltransferase KAT7 in AMLs driven by the MLL-X gene fusions.	Lysine	40-46	lysine acetyltransferase 7	Homo sapiens	65-69
32764680-4	2021	Here we investigate the essentiality of lysine acetyltransferase KAT7 in AMLs driven by the MLL-X gene fusions.	Lysine	40-46	lysine methyltransferase 2A	Homo sapiens	92-95
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Lysine	42-48	Prophenoloxidase 1	Drosophila melanogaster	176-192
33559339-1	2021	Histone-3-lysine-4 (H3K4) methylation is catalysed by the multiprotein complex known as the Set1/COMPASS or MLL/COMPASS-like complex, an element that is highly evolutionarily conserved from yeast to humans.	Lysine	10-16	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	92-96
1545783-1	1992	The very lysine-rich replacement histone variant H1(0) is found to be present in different murine (C1003, PC13, P19) and human (Tera-2) embryonal carcinoma cell lines.	Lysine	9-15	interleukin 23, alpha subunit p19	Mus musculus	112-115
1378653-1	1992	A 9 amino acid peptide, Ser-Pro-Arg-Ser-Phe-Gln-Lys-Lys-Thr, corresponding to the clotting factor VIII (FVIII) sequence Ser1687-Thr1695, was synthesized in order to analyze a site on FVIII to which antibody inhibitors of FVIII may be directed.	Lysine	48-51	coagulation factor VIII	Homo sapiens	91-102
1378653-1	1992	A 9 amino acid peptide, Ser-Pro-Arg-Ser-Phe-Gln-Lys-Lys-Thr, corresponding to the clotting factor VIII (FVIII) sequence Ser1687-Thr1695, was synthesized in order to analyze a site on FVIII to which antibody inhibitors of FVIII may be directed.	Lysine	48-51	coagulation factor VIII	Homo sapiens	104-109
1378653-1	1992	A 9 amino acid peptide, Ser-Pro-Arg-Ser-Phe-Gln-Lys-Lys-Thr, corresponding to the clotting factor VIII (FVIII) sequence Ser1687-Thr1695, was synthesized in order to analyze a site on FVIII to which antibody inhibitors of FVIII may be directed.	Lysine	48-51	coagulation factor VIII	Homo sapiens	183-188
1378653-1	1992	A 9 amino acid peptide, Ser-Pro-Arg-Ser-Phe-Gln-Lys-Lys-Thr, corresponding to the clotting factor VIII (FVIII) sequence Ser1687-Thr1695, was synthesized in order to analyze a site on FVIII to which antibody inhibitors of FVIII may be directed.	Lysine	48-51	coagulation factor VIII	Homo sapiens	183-188
33738896-8	2021	Combination treatment with PI and deubiquitinating enzyme (DUB) inhibitors overcame this drug resistance by restoring cyclin A1 expression through chromatin crosstalk between histone H2B monoubiquitination and MLL-mediated histone H3 lysine 4 methylation.	Lysine	234-240	cyclin A1	Homo sapiens	118-127
33738896-8	2021	Combination treatment with PI and deubiquitinating enzyme (DUB) inhibitors overcame this drug resistance by restoring cyclin A1 expression through chromatin crosstalk between histone H2B monoubiquitination and MLL-mediated histone H3 lysine 4 methylation.	Lysine	234-240	lysine methyltransferase 2A	Homo sapiens	210-213
17420289-5	2007	Substitution of all lysine residues within the Ubl domain abolishes lysine-63-linked polyubiquitination of Herp in vitro and calcium-induced Herp relocalization that is also abrogated by the overexpression of a dominant-negative POSHV14A.	Lysine	20-26	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	141-145
17420289-5	2007	Substitution of all lysine residues within the Ubl domain abolishes lysine-63-linked polyubiquitination of Herp in vitro and calcium-induced Herp relocalization that is also abrogated by the overexpression of a dominant-negative POSHV14A.	Lysine	68-74	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	107-111
17347654-6	2007	CUEDC2 decreases the sumoylation while promoting ubiquitination on Lys-388 of PRB.	Lysine	67-70	RB transcriptional corepressor 1	Homo sapiens	78-81
33571875-1	2021	Tumor suppressor p53-binding protein 1 (53BP1), a tantem tudor domain (TTD) protein, takes part in DNA Damage Repair (DDR) pathways through the specific recognition of lysine methylation on histones.	Lysine	168-174	tumor protein p53 binding protein 1	Homo sapiens	0-38
33571875-1	2021	Tumor suppressor p53-binding protein 1 (53BP1), a tantem tudor domain (TTD) protein, takes part in DNA Damage Repair (DDR) pathways through the specific recognition of lysine methylation on histones.	Lysine	168-174	tumor protein p53 binding protein 1	Homo sapiens	40-45
33576509-3	2021	The homologous ubiquitin-conjugating (E2) enzymes Ubc1 (budding yeast) and Ube2K (mammals) exclusively generate polyubiquitin linked through lysine 48 (K48).	Lysine	141-147	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	50-54
1309759-10	1992	Rather, the presence of a pair of lysines (Lys4-Lys5) within the relatively unstructured N-terminal extension of the yeast cytochromes c may be responsible for their preferential ubiquitination.	Lysine	34-41	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	48-52
17389396-3	2007	In addition to members of the Set1 complex that mediate histone H3 lysine 4 methylation (H3K4me), we found that deleting members of the CCR4/NOT mRNA processing complex exhibit synthetic phenotypes when combined with proteasome mutants.	Lysine	67-73	C-C motif chemokine receptor 4	Homo sapiens	136-140
1731881-1	1992	Pyridoxal 5"-phosphate (PLP), a lysine-specific reagent, has been used to modify G-actin.	Lysine	32-38	pyridoxal phosphatase	Homo sapiens	24-27
1731881-2	1992	At pH 7.5, PLP reacted with 1.7-2 lysines on G-actin.	Lysine	34-41	pyridoxal phosphatase	Homo sapiens	11-14
1731881-3	1992	Limited proteolytic digestion experiments indicated that, in agreement with previous works, essentially lysine-61 was modified in a 1:1 fashion by PLP, other lysines being much less reactive.	Lysine	104-110	pyridoxal phosphatase	Homo sapiens	147-150
33682127-6	2021	The gels containing 15/20 mM Lys/Arg exhibited a significant increase in the proportion of immobilized water (P21 ).	Lysine	29-32	H3 histone pseudogene 16	Homo sapiens	110-113
33682127-7	2021	CONCLUSION: The enhancement of WHC, gel strength, and P21 was closely associated with the increased solubility and the dense microstructure induced by Lys and Arg with high concentrations of 15 mM and 20 mM.	Lysine	151-154	H3 histone pseudogene 16	Homo sapiens	54-57
1731881-4	1992	A PLP-derivatized affinity label of ATP binding sites, AMPPLP, reacted with two additional lysines that do not appear to be located in the ATP site on G-actin.	Lysine	91-98	pyridoxal phosphatase	Homo sapiens	2-5
17116355-2	2007	We have recently shown that PLP acted as a competitive inhibitor of C. guilliermondii topoisomerase I, impeding the formation of the cleavable complex from a selective binding to an active site lysine.	Lysine	194-200	pyridoxal phosphatase	Homo sapiens	28-31
1730585-3	1992	To explain our results, we propose a model in which plasmin can exist in two conformations of lower activity (kcat/Km = 1.4 x 10(6) M-1 s-1) or higher activity (kcat/Km = 16.7 x 10(6) M-1 s-1) depending on whether a lysine binding site is occupied or free, respectively.	Lysine	216-222	plasminogen	Homo sapiens	52-59
33676897-9	2021	Additionally, beta-TrCP1 impedes MDM2 accumulation via abrogation of its lysine 63-linked polyubiquitination by beta-TrCP2.	Lysine	73-79	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	14-24
1312335-5	1992	Acetylations and phosphorylations markedly affect the charge densities of these domains whereas ubiquitination adds a bulky globular protein, ubiquitin, to lysines in the C-terminal tails of H2A and H2B.	Lysine	156-163	H2A clustered histone 18	Homo sapiens	191-202
17116355-5	2007	We have proposed that PLP could be used as a new lead for anticancer drugs trapping the active site lysine (K(532)) and also as a tool to explore the enzyme dynamics required for catalysis.	Lysine	100-106	pyridoxal phosphatase	Homo sapiens	22-25
17251291-4	2007	A CXCR3 variant carrying the CXCR4 binding pocket was constructed by simultaneous lysine-to-alanine and serine-to-glutamate substitutions at positions 300 and 304 of the CXCR3 receptor.	Lysine	82-88	C-X-C motif chemokine receptor 3	Homo sapiens	2-7
1370273-3	1992	Glu-plasmin formed on the streptococcal surface was further converted to the Lys form.	Lysine	77-80	plasminogen	Homo sapiens	4-11
33663609-10	2021	Moreover, the decreased histone 3 lysine 9 acetylation (H3K9ac) level of TGFbetaRI and its expression were observed in IUGR-derived WJ-MSCs and normal WJ-MSCs treated with excessive cortisol, which could be abolished by RU486 and LMK235.	Lysine	34-40	transforming growth factor beta receptor 1	Homo sapiens	73-82
17205979-9	2007	Studies of these mutants revealed that trimethylation of Lys(347) of RARalpha facilitated its interactions with cofactors p300/CREB-binding protein-associated factor and receptor-interacting protein 140 as well as its heterodimeric partner retinoid X receptor, suggesting that site-specific hydrophobicity at Lys(347) enhanced molecular interaction of RARalpha with its modulators.	Lysine	57-60	E1A binding protein p300	Homo sapiens	122-126
33505026-8	2021	METTL3 also interacts physically with the histone 3 lysine 9 (H3K9) tri-methyltransferase SETDB1 and its cofactor TRIM28, and is important for their localization to IAPs.	Lysine	52-58	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	0-6
1662495-2	1991	Specific modification of lysine-9 sidechain with NHS-LC-biotin (Et-1[BtK9]) produced a derivative with maximal binding and retention of vascular smooth muscle contractile activity.	Lysine	25-31	endothelin-1	Cricetulus griseus	64-68
1662495-7	1991	Thus, biotinylation of Et-1 at the lysine-9 sidechain may be of general use for localization and typing of Et-receptor populations.	Lysine	35-41	endothelin-1	Cricetulus griseus	23-27
33649478-7	2021	Acetylation of lysine residue 16 on histone H4 (H4K16ac), which is catalyzed by the MSL complex, was undetectable in these cells.	Lysine	15-21	histone H4	Drosophila melanogaster	36-46
17244610-6	2007	Mutation of this Lys plus four additional residues, predicted to be neighbors in an assumed alpha-helical TMD arrangement, abrogated the TAP2-stabilizing capacity of Tpn.	Lysine	17-20	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	137-141
33503260-5	2021	Loss of BACH1 reduced the interaction between NANOG and MLL1/SET1 complexes, and decreased their occupancy on chromatin, and further decreased H3 lysine 4 trimethylation (H3K4me3) level on gene promoters and (super-) enhancers, leading to decreased enhancer activity and transcription activity, especially on stemness-related genes.	Lysine	146-152	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	8-13
17255098-6	2007	The final localization of [125I]RTI 82 incorporation to rat DAT Met(290)-Lys(336) and human DAT I291M to R344M provides positive evidence for the proximity of cocaine binding to TM6.	Lysine	73-76	solute carrier family 6 member 3	Rattus norvegicus	60-63
33631195-4	2021	Lysyl hydroxylase 1 (LH1) is required to hydroxylate lysine for cross-linking and carbohydrate attachment within collagen triple helical sequences.	Lysine	53-59	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Mus musculus	0-19
33631195-4	2021	Lysyl hydroxylase 1 (LH1) is required to hydroxylate lysine for cross-linking and carbohydrate attachment within collagen triple helical sequences.	Lysine	53-59	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	21-24
1764065-3	1991	Bovine tissue factor had three potential N-glycosylation sites, four extracellular cysteine residues, a cytoplasmic cysteine residue, and one tripeptide tryptophan-lysine-serine motif.	Lysine	164-170	LOC101909187	Bos taurus	7-20
1837350-3	1991	By site-directed mutagenesis of trk oncogene cDNA, the codon for lysine (367) at the putative ATP-binding site was changed to that for methionine and the codons for tyrosines (503 and 504) at the putative autophosphorylation sites were changed to those for phenylalanine.	Lysine	65-71	neurotrophic receptor tyrosine kinase 1	Homo sapiens	32-35
17320083-7	2007	To further understand the mechanism, we generated a lysine-less mutant KLF5(1-171).	Lysine	52-58	Kruppel like factor 5	Homo sapiens	71-75
1667373-7	1991	Structural analysis of the abnormal Hb by micro-crystal cellulose membrane and high performance liquid chromatography (HPLC) demonstrated that all the 11 cases of Hb variant in the native residents are HbE [ beta 26 (B8) Glu----Lys].	Lysine	228-231	hemoglobin subunit epsilon 1	Homo sapiens	202-205
33672962-2	2021	Transglutaminase 2 (TG2) is a crosslinking enzyme that forms a covalent bond between lysine and glutamine.	Lysine	85-91	transglutaminase 2, C polypeptide	Mus musculus	0-18
33672962-2	2021	Transglutaminase 2 (TG2) is a crosslinking enzyme that forms a covalent bond between lysine and glutamine.	Lysine	85-91	transglutaminase 2, C polypeptide	Mus musculus	20-23
17218320-5	2007	Histone H3 acetylation and Lys-4 tri-methylation were specifically associated with IL-17 and IL-17F gene promoters in THi lineage.	Lysine	27-30	interleukin 17F	Homo sapiens	93-99
33633752-7	2020	In Brassica species, the vernalization response including the repression of FLC expression by cold treatment and the enrichment of the repressive histone modification tri-methylated histone H3 lysine 27 (H3K27me3) at the FLC locus is similar to A. thaliana.	Lysine	193-199	MADS-box protein FLOWERING LOCUS C	Brassica napus	221-224
1657983-8	1991	Binding of 125I-Lys-PLG, but not 125I-t-PA, to t-PA-R was 80% inhibited by a 20-100-fold molar excess of the PLG-like lipoprotein(a), or by the lysine analog, epsilon-aminocaproic acid (50 mM).	Lysine	144-150	plasminogen	Homo sapiens	20-23
1657983-8	1991	Binding of 125I-Lys-PLG, but not 125I-t-PA, to t-PA-R was 80% inhibited by a 20-100-fold molar excess of the PLG-like lipoprotein(a), or by the lysine analog, epsilon-aminocaproic acid (50 mM).	Lysine	144-150	plasminogen	Homo sapiens	109-112
1657983-10	1991	Biosynthetically labeled 40-kDa protein coprecipitated with t-PA- or Lys-PLG-Sepharose beads, but not with unconjugated Sepharose.	Lysine	69-72	plasminogen	Homo sapiens	73-76
17342255-1	2007	Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitors of furin, a mammalian proprotein convertase.	Lysine	30-36	furin, paired basic amino acid cleaving enzyme	Homo sapiens	99-104
1657983-12	1991	These results suggest that t-PA-R can bind both t-PA and Lys-PLG in a manner that mimics the EC surface.	Lysine	57-60	plasminogen	Homo sapiens	61-64
33369872-7	2021	Ubiquitin remnant profiling identified receptor-interacting protein kinase 3 (RIPK3) lysines 42, 351, and 518 as novel, USP22-regulated ubiquitination sites during necroptosis.	Lysine	85-92	ubiquitin specific peptidase 22	Homo sapiens	120-125
17426003-2	2007	METHODS: Platelet CD42a was modified by 5 kD and 20 kD mPEG-SPA, respectively, and the fluorescence intensity of CD42a was detect by flow cytometry and the three-dimensional structure of CD42a simulated to analyze the distribution of lysine in CD42a molecule.	Lysine	234-240	glycoprotein IX platelet	Homo sapiens	18-23
33327751-8	2021	Mechanistically, SIRT3 deacetylates and activates PDHA1 (pyruvate dehydrogenase E1 alpha) at lysine 83, and the loss of SIRT3 leads to PDH activity decrease and lactate accumulation.	Lysine	93-99	sirtuin 3	Mus musculus	17-22
1959601-1	1991	Bullfrog thyroglobulin was digested with lysyl endopeptidase, known to be highly specific to cut the C-terminal side of lysine residue in protein, after reduction and carboxymethylation.	Lysine	120-126	thyroglobulin	Bos taurus	9-22
17426003-2	2007	METHODS: Platelet CD42a was modified by 5 kD and 20 kD mPEG-SPA, respectively, and the fluorescence intensity of CD42a was detect by flow cytometry and the three-dimensional structure of CD42a simulated to analyze the distribution of lysine in CD42a molecule.	Lysine	234-240	glycoprotein IX platelet	Homo sapiens	113-118
17426003-2	2007	METHODS: Platelet CD42a was modified by 5 kD and 20 kD mPEG-SPA, respectively, and the fluorescence intensity of CD42a was detect by flow cytometry and the three-dimensional structure of CD42a simulated to analyze the distribution of lysine in CD42a molecule.	Lysine	234-240	glycoprotein IX platelet	Homo sapiens	113-118
1924357-6	1991	Conversely, dipeptides His-Ala, Arg-Ala, and Lys-Ala inhibit the degradation of Arg-nsP4 but not of Tyr-nsP4 or Phe-nsP4.	Lysine	45-48	serine protease 57	Homo sapiens	84-88
17426003-2	2007	METHODS: Platelet CD42a was modified by 5 kD and 20 kD mPEG-SPA, respectively, and the fluorescence intensity of CD42a was detect by flow cytometry and the three-dimensional structure of CD42a simulated to analyze the distribution of lysine in CD42a molecule.	Lysine	234-240	glycoprotein IX platelet	Homo sapiens	113-118
32935630-11	2021	In addition, p65 phosphorylation at Ser-276 induced acetyl transferase p300 recruitment, leading to its acetylation on Lys-310 and thereby enhancing its transcriptional activity.	Lysine	119-122	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	13-16
17426003-3	2007	RESULTS: After platelet CD42a modification by 5 kD and 20 kD mPEG-SPA, the fluorescence intensity of CD42a decreased sharply by 85.54% and 88.65%, respectively, and multiple lysine regions were identified on the surface of CD42a molecule.	Lysine	174-180	glycoprotein IX platelet	Homo sapiens	24-29
33842849-0	2021	UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213-UBC13 axis is responsible for angiogenic activity.	Lysine	67-73	ubiquitin conjugating enzyme E2 N	Homo sapiens	113-118
1724377-0	1991	A basic region neighboring the lysine-rich C-terminus of protein SRP19 is required for binding to signal recognition particle RNA.	Lysine	31-37	signal recognition particle 19	Homo sapiens	65-70
17426003-3	2007	RESULTS: After platelet CD42a modification by 5 kD and 20 kD mPEG-SPA, the fluorescence intensity of CD42a decreased sharply by 85.54% and 88.65%, respectively, and multiple lysine regions were identified on the surface of CD42a molecule.	Lysine	174-180	surfactant protein A1	Homo sapiens	66-69
33535351-1	2021	The human epigenetic gene of SET domain containing 2 (SETD2) is located at the cytogenetic band p21.31 of chromosome 3, which encodes the histone3 lysine36 trimethyltransferase SETD2, the major enzyme that catalyzes the trimethylation of lysine 36 on histone 3 (H3K36me3) of human.	Lysine	147-153	H3 histone pseudogene 16	Homo sapiens	96-99
17189254-5	2007	SDS-PAGE analysis showed that plasmin cleaved the heavy chain of factor VIII into two terminal products, A1(37-336) and A2 subunits, by limited proteolysis at Lys(36), Arg(336), Arg(372), and Arg(740).	Lysine	159-162	plasminogen	Homo sapiens	30-37
33472079-7	2021	The cytosolic ERAL1 facilitates lysine 63 (K63)-linked ubiquitination of retinoicacid inducible gene-1 (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) and promotes downstream MAVS polymerization, thus positively regulating antiviral responses.	Lysine	32-38	Era (G-protein)-like 1 (E. coli)	Mus musculus	14-19
33472082-5	2021	Through modification of SQSTM1/p62 on lysine 435, the ER-embedded UBE2J1/RNF26 ubiquitylation complex recruits endosomal adaptors to immobilize their cognate vesicles in the perinuclear region of the cell.	Lysine	38-44	ubiquitin conjugating enzyme E2 J1	Homo sapiens	66-72
1879604-4	1991	This protein, designated as H1X, was regarded as an H1 subtype on the basis of its solubility in acids or salt and its lysine-rich amino acid composition.	Lysine	119-125	H1.10 linker histone S homeolog	Xenopus laevis	28-31
17189254-11	2007	Furthermore, the cleavages at Arg(336) and Lys(36) appeared to be selectively regulated by the A2 and A3-C1-C2 domains, respectively, interacting with plasmin.	Lysine	43-46	plasminogen	Homo sapiens	151-158
17301242-4	2007	Here, we show that C/EBPbeta is acetylated by GCN5 and PCAF within a cluster of lysine residues between amino acids 98-102 and that this acetylation is strongly induced by glucocorticoid treatment.	Lysine	80-86	CCAAT enhancer binding protein beta	Homo sapiens	19-28
1911840-7	1991	Sequence analysis indicated that calmodulin proteinase cleaves calmodulin at Lys-75.	Lysine	77-80	calmodulin 1	Rattus norvegicus	33-43
1911840-7	1991	Sequence analysis indicated that calmodulin proteinase cleaves calmodulin at Lys-75.	Lysine	77-80	calmodulin 1	Rattus norvegicus	63-73
33614242-8	2021	Furthermore, the expression of miR-1224 was inhibited by CREB through EZH2-mediated histone 3 lysine 27 (H3K27me3) on miR-1224 promoter, thus forming a positive feedback circuit.	Lysine	94-100	microRNA 1224	Homo sapiens	31-39
33614242-8	2021	Furthermore, the expression of miR-1224 was inhibited by CREB through EZH2-mediated histone 3 lysine 27 (H3K27me3) on miR-1224 promoter, thus forming a positive feedback circuit.	Lysine	94-100	microRNA 1224	Homo sapiens	118-126
33467728-2	2021	Here, we explore the ability of human KAT8 to catalyse the acetylation of histone H4 peptides possessing lysine and its analogues at position 16 (H4K16).	Lysine	105-111	H4 clustered histone 6	Homo sapiens	74-84
33523871-4	2021	In this study, we found that IKKbeta ubiquitination on lysine-238 was substantially increased during inflammation.	Lysine	55-61	conserved helix-loop-helix ubiquitous kinase	Mus musculus	29-36
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Lysine	75-78	ghrelin and obestatin prepropeptide	Rattus norvegicus	10-42
17301242-4	2007	Here, we show that C/EBPbeta is acetylated by GCN5 and PCAF within a cluster of lysine residues between amino acids 98-102 and that this acetylation is strongly induced by glucocorticoid treatment.	Lysine	80-86	lysine acetyltransferase 2B	Homo sapiens	55-59
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Lysine	75-78	ghrelin and obestatin prepropeptide	Rattus norvegicus	44-48
1712588-1	1991	Since the growth hormone-releasing peptide (GHRP), His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, was found to specifically release growth hormone by a complementary but yet not clearly defined action on the pituitary as well as the hypothalamus, in vitro studies have been performed to demonstrate and characterized GHRP binding sites on peripheral membranes of both the rat anterior pituitary and hypothalamus.	Lysine	75-78	ghrelin and obestatin prepropeptide	Rattus norvegicus	303-307
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Lysine	29-35	CCAAT enhancer binding protein beta	Homo sapiens	77-86
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Lysine	29-35	CCAAT enhancer binding protein beta	Homo sapiens	163-172
33511127-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 and contains a SET domain that catalyzes histone H3 trimethylation on lysine 27 (H3K27me3) to generate an epigenetic silencing mark.	Lysine	163-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Sus scrofa	0-27
33511127-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 and contains a SET domain that catalyzes histone H3 trimethylation on lysine 27 (H3K27me3) to generate an epigenetic silencing mark.	Lysine	163-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Sus scrofa	29-33
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Lysine	29-35	CCAAT enhancer binding protein beta	Homo sapiens	163-172
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	Thy-1 cell surface antigen	Homo sapiens	97-101
1904273-1	1991	A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP).	Lysine	32-38	PLF	Homo sapiens	129-132
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	POU class 5 homeobox 1	Homo sapiens	187-193
17158926-2	2007	Lysine acetylation has been shown to modulate MEF2 function, but it is not so clear which deacetylase(s) is involved.	Lysine	0-6	myocyte enhancer factor 2A	Homo sapiens	46-50
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	228-234	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	111-115
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	280-286	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	111-115
17245431-6	2007	In addition, DNA-bound CTIP2 also associates with the histone methyltransferase SUV39H1, which increases local histone H3 lysine 9 methylation.	Lysine	122-128	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	23-28
32882370-3	2021	Eukaryotic Translation Initiation Factor 5A undergoes a unique post-translation modification of lysine to hypusine (K50), which determines eIF5A binding partners.	Lysine	96-102	eukaryotic translation initiation factor 5A	Homo sapiens	0-43
2044150-2	1991	Histone H4 N-terminal residues 4-23, which include the extremely conserved, reversibly acetylated lysines (at positions 5, 8, 12, and 16), were found to encompass a region required for the activation of the GAL1 promoter.	Lysine	98-105	galactokinase	Saccharomyces cerevisiae S288C	207-211
32882370-3	2021	Eukaryotic Translation Initiation Factor 5A undergoes a unique post-translation modification of lysine to hypusine (K50), which determines eIF5A binding partners.	Lysine	96-102	eukaryotic translation initiation factor 5A	Homo sapiens	139-144
17098746-5	2007	In addition to the C-terminal lysine residues, FBXO11 can also promote Nedd8 conjugation to Lys-320 and Lys-321, and neddylation of p53 leads to suppression of p53 function.	Lysine	92-95	NEDD8 ubiquitin like modifier	Homo sapiens	71-76
1647011-5	1991	More than one lysine residue of alpha 2 can be joined to ubiquitin, and some of the ubiquitin moieties form a Lys48-linked multiubiquitin chain.	Lysine	14-20	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	32-39
17314514-0	2007	Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding.	Lysine	49-56	Cyclin A	Drosophila melanogaster	0-8
1851166-6	1991	Because of the sensitivity afforded by the use of 125I-Ub in this "stutter-step" sequencing method, minor ubiquitination at Lys-8 also was detected.	Lysine	124-127	ubiquitin	Saccharomyces cerevisiae S288C	55-57
33107021-1	2021	BRCA1/BRCA2-containing complex subunit 3 (BRCC3) is a lysine 63-specific deubiquitinase involved in multiple biological processes, such as DNA repair and immune responses.	Lysine	54-60	BRCA1/BRCA2-containing complex, subunit 3	Mus musculus	0-40
33107021-1	2021	BRCA1/BRCA2-containing complex subunit 3 (BRCC3) is a lysine 63-specific deubiquitinase involved in multiple biological processes, such as DNA repair and immune responses.	Lysine	54-60	BRCA1/BRCA2-containing complex, subunit 3	Mus musculus	42-47
33289299-3	2021	Recently, we reported the identification of inhibitors of the histone lysine demethylase JMJD1C that preferentially kill MLL rearranged acute leukemia cells.	Lysine	70-76	lysine methyltransferase 2A	Homo sapiens	121-124
17097793-9	2007	Further variants comprising DDDDK(156)SS, DDDDK(156)SD and DDDDK(156)RR showed that the minimal critical determinants for enhanced enterokinase cleavage are serine in the P1" position followed by a serine or a basic residue, lysine or arginine, in the P2" position.	Lysine	225-231	transmembrane protease, serine 15	Mus musculus	131-143
33303641-2	2021	By identifying a novel p53 acetylation site at lysine K136, we found that simultaneous mutations at all five acetylation sites (p53-5KR) diminished its remaining tumor suppression function.	Lysine	47-53	transformation related protein 53, pseudogene	Mus musculus	23-26
33303641-2	2021	By identifying a novel p53 acetylation site at lysine K136, we found that simultaneous mutations at all five acetylation sites (p53-5KR) diminished its remaining tumor suppression function.	Lysine	47-53	transformation related protein 53, pseudogene	Mus musculus	128-131
1908577-3	1991	In both experiments at each CP level, there was an optimum lysine content for weight gain and feed conversion ratio (FCR).	Lysine	59-65	FCR	Gallus gallus	94-115
1908577-3	1991	In both experiments at each CP level, there was an optimum lysine content for weight gain and feed conversion ratio (FCR).	Lysine	59-65	FCR	Gallus gallus	117-120
1908577-5	1991	Combining all data gave a significant improvement in both weight gain and FCR with increasing intake of dietary lysine.	Lysine	112-118	FCR	Gallus gallus	74-77
17257442-11	2007	CONCLUSION: We show that the majority of lysine-dependent plasminogen binding to breast cancer cells is ultimately regulated by plasmin activity and is dependent on the presence of significant levels of active uPA.	Lysine	41-47	plasminogen	Homo sapiens	58-65
1999425-2	1991	SOD-1- strains are unable to grow in 100% O2 in rich medium and are methionine and lysine auxotrophic when grown in air (Bilinski, T., Krawiec, Z., Liczmanski, A., and Litwinska, J.	Lysine	83-89	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	0-5
33151904-2	2021	Mixed lineage leukemia 1 (MLL1), a histone methyltransferase, is crucial for gene expression by catalyzing the trimethylation of histone 3 lysine 4 (H3K4me3) in gene promoter.	Lysine	139-145	lysine methyltransferase 2A	Homo sapiens	0-24
33151904-2	2021	Mixed lineage leukemia 1 (MLL1), a histone methyltransferase, is crucial for gene expression by catalyzing the trimethylation of histone 3 lysine 4 (H3K4me3) in gene promoter.	Lysine	139-145	lysine methyltransferase 2A	Homo sapiens	26-30
1703440-6	1991	In the presence of tranexamic acid or 6-aminohexanoic acid, lysine analogues that mimic the effects of fibrin, plasmin binding kinetics are changed such that equilibrium is reached slowly following a lag phase after mixing of enzyme and inhibitor.	Lysine	60-66	plasminogen	Homo sapiens	111-118
17311554-3	2007	Among them, CPU, also known as thrombin-activatable fibrinolysis inhibitor (TAFI), has been shown to cleave C-terminal Lys residues from partially degraded fibrin, acting as inhibitor of clot fibrinolysis and therefore constituting an important drug target for thrombolytic therapies.	Lysine	119-122	carboxypeptidase B2	Homo sapiens	31-74
1843556-3	1991	Glucosylated ovalbumin, human serum albumin, gamma-globulin and myoglobin show reduced susceptibility to degradation by trypsin as compared to the nonglucated proteins, apparently by direct modification of lysine residues.	Lysine	206-212	ovalbumin	Bos taurus	13-22
33325147-2	2021	Lysine methyltransferase, encoded by KMT2A, plays critical roles in the regulation of gene expression during early development.	Lysine	0-6	lysine methyltransferase 2A	Homo sapiens	37-42
17311554-3	2007	Among them, CPU, also known as thrombin-activatable fibrinolysis inhibitor (TAFI), has been shown to cleave C-terminal Lys residues from partially degraded fibrin, acting as inhibitor of clot fibrinolysis and therefore constituting an important drug target for thrombolytic therapies.	Lysine	119-122	carboxypeptidase B2	Homo sapiens	76-80
33316537-4	2021	In this study, we found that SUMOylation can occur in the Sirt2 protein at both lysine 183 and lysine 340 sites.	Lysine	80-86	sirtuin 2	Homo sapiens	58-63
33316537-4	2021	In this study, we found that SUMOylation can occur in the Sirt2 protein at both lysine 183 and lysine 340 sites.	Lysine	95-101	sirtuin 2	Homo sapiens	58-63
2120231-6	1990	Residue X was identified as lysine-134 from the SBP amino acid sequence (Walsh, K. A., Titani, K., Kumar, S., Hayes, R., and Petra, P. H. (1986) Biochemistry 25, 7584-7590).	Lysine	28-34	selenium binding protein 1	Homo sapiens	48-51
17140415-3	2007	We show that aspartate kinase 2 and aspartate kinase 3 are inhibited only by lysine, and that aspartate kinase 1 is inhibited in a synergistic manner by lysine and SAM.	Lysine	153-159	protein kinase 2A	Arabidopsis thaliana	104-112
33122827-11	2021	Mechanistically, downregulation of LINC00261 was caused by hypermethylation of the CpG island in the promoter region and EZH2-mediated histone H3 lysine 27 trimethylation.	Lysine	146-152	long intergenic non-protein coding RNA 261	Homo sapiens	35-44
17140415-4	2007	In the absence of SAM, aspartate kinase 1 displayed low apparent affinity for lysine compared to aspartate kinase 2 and aspartate kinase 3.	Lysine	78-84	protein kinase 2A	Arabidopsis thaliana	33-41
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Lysine	40-43	Auxin efflux carrier family protein	Arabidopsis thaliana	95-99
17140415-5	2007	In the presence of SAM, the apparent affinity of aspartate kinase 1 for lysine increased considerably, with K(0.5) values for lysine inhibition similar to those of aspartate kinase 2 and aspartate kinase 3.	Lysine	72-78	aspartate kinase 1	Arabidopsis thaliana	49-67
17140415-5	2007	In the presence of SAM, the apparent affinity of aspartate kinase 1 for lysine increased considerably, with K(0.5) values for lysine inhibition similar to those of aspartate kinase 2 and aspartate kinase 3.	Lysine	126-132	aspartate kinase 1	Arabidopsis thaliana	49-67
17140415-9	2007	SAM by itself had no effect on the enzyme activity, in accordance with equilibrium binding analyses indicating that SAM binding to aspartate kinase 1 requires prior binding of lysine.	Lysine	176-182	protein kinase 2A	Arabidopsis thaliana	141-149
2219707-5	1990	In contrast, the integrity of a second potential Tat activation motif, centered on a lysine residue at position 41, was found to be essential for Tat function.	Lysine	85-91	tyrosine aminotransferase	Homo sapiens	49-52
2219707-5	1990	In contrast, the integrity of a second potential Tat activation motif, centered on a lysine residue at position 41, was found to be essential for Tat function.	Lysine	85-91	tyrosine aminotransferase	Homo sapiens	146-149
17140415-12	2007	The increase in aspartate kinase 1 apparent affinity for lysine in the presence of SAM thus results from the displacement of the unfavorable equilibrium between aspartate kinase 1 and aspartate kinase 1-Lys towards the inactive form.	Lysine	57-63	protein kinase 2A	Arabidopsis thaliana	26-34
33379275-2	2020	Recent findings have suggested that aberrant methylation of histone H3 lysine 79 residue (H3K79me) by the histone methyltransferase disruptor of telomeric silencing 1-like (DOT1L) is a potential therapeutic target for TNBC clinical management.	Lysine	71-77	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	173-178
17140415-12	2007	The increase in aspartate kinase 1 apparent affinity for lysine in the presence of SAM thus results from the displacement of the unfavorable equilibrium between aspartate kinase 1 and aspartate kinase 1-Lys towards the inactive form.	Lysine	57-63	protein kinase 2A	Arabidopsis thaliana	171-202
17486496-0	2007	Three new alpha-globin variants: Hb Itapira [alpha30(B11)Glu-->Val (alpha1)], Hb Bom Jesus Da Lapa [alpha30(B11)Glu-->Ala (alpha1)] and Hb Boa Esperanca [alpha16(A14)Lys-->Thr (alpha2)].	Lysine	166-169	hemoglobin subunit alpha 2	Homo sapiens	10-22
33087443-8	2020	However, Lysine to Glutamic acid substitutions at the KTKEGV repeat domain of alpha-Syn, that interfere with phospholipid binding, are ineffective in enhancing CME.	Lysine	9-15	synuclein alpha	Homo sapiens	78-87
2188100-3	1990	Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating GCN4 expression.	Lysine	35-41	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	222-226
17060459-5	2007	TDG is also posttranslationally modified by covalent conjugation of SUMO-1 (sumoylation) to lysine 341.	Lysine	92-98	small ubiquitin like modifier 1	Homo sapiens	68-74
2328319-7	1990	Partial amino acid sequencing showed that the Sp alpha I/74 Kd peptide resulted from cleavage at lysine residue 42 of the Sp alpha I/80 Kd domain.	Lysine	97-103	surfactant protein A1	Homo sapiens	46-54
2328319-7	1990	Partial amino acid sequencing showed that the Sp alpha I/74 Kd peptide resulted from cleavage at lysine residue 42 of the Sp alpha I/80 Kd domain.	Lysine	97-103	surfactant protein A1	Homo sapiens	122-130
32988591-7	2020	In both Ift20:Wnt1-Cre and Ift20:Ocn-Cre mice the bones exhibit increased hydroxylysine-aldehyde deived cross-linking, and decreased lysine-aldehyde derived cross-linking.	Lysine	81-87	intraflagellar transport 20	Mus musculus	8-13
32988591-7	2020	In both Ift20:Wnt1-Cre and Ift20:Ocn-Cre mice the bones exhibit increased hydroxylysine-aldehyde deived cross-linking, and decreased lysine-aldehyde derived cross-linking.	Lysine	81-87	intraflagellar transport 20	Mus musculus	27-32
32988591-10	2020	These results suggest that IFT20 plays a pivotal role in collagen biosynthesis by regulating, in part, telopeptidyl lysine hydroxylation and cross-linking in bone.	Lysine	116-122	intraflagellar transport 20	Mus musculus	27-32
2155851-9	1990	SOE1 is a single C to T mutation in the anticodon of a tRNA(3Glu) gene and thereby, produces a missense suppressor tRNA capable of recognizing AAA lysine codons.	Lysine	147-153	SOE1	Saccharomyces cerevisiae S288C	0-4
17979108-9	2007	Sequencing revealed that the peptides were predominantly amino- and carboxy-terminal protein fragments displaying a specificity characteristic of the acidic proteases cathepsin D and E. Many of the identified peptides contained arginine and/or lysine, allowing determination of the incorporation rate of these amino acids.	Lysine	244-250	cathepsin D	Homo sapiens	167-178
2303410-5	1990	Altered cDNAs encoding pro-NPY with -Arg-Arg-, -Arg-Lys-, or Lys-Lys- at the cleavage site were used to generate stable cell lines.	Lysine	52-55	neuropeptide Y	Mus musculus	23-30
2303410-9	1990	Pro-NPY(-Arg-Arg-) was cleaved at a rate similar to that observed for the wild-type pro-NPY(-Lys-Arg-).	Lysine	93-96	neuropeptide Y	Mus musculus	0-7
33238306-2	2020	For example, lysine acetylation in histone H4 is correlated with activation of RNA polymerase I-, II- and III-driven transcription from chromatin templates, which requires prior chromatin remodeling.	Lysine	13-19	histone H4	Xenopus laevis	35-45
32988590-1	2020	Histone lysine N-methyltransferase 2D (KMT2D), an important methyltransferase that is involved in the methylation of lysine 4 in histone H3 (H3K4) and related to the development of prostate cancer.	Lysine	8-14	lysine methyltransferase 2D	Homo sapiens	39-44
2303410-9	1990	Pro-NPY(-Arg-Arg-) was cleaved at a rate similar to that observed for the wild-type pro-NPY(-Lys-Arg-).	Lysine	93-96	neuropeptide Y	Mus musculus	84-91
17077080-2	2006	Conjugation of small ubiquitin-like modifier type 1 (SUMO-1) to lysines in the negative regulatory domain strongly suppresses its transcriptional activity.	Lysine	64-71	small ubiquitin like modifier 1	Homo sapiens	15-51
33201982-4	2020	First, we constructed several rsp5 mutants producing Rsp5 variants without the C2 domain or with amino acid changes of membrane-binding lysine residues.	Lysine	136-142	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	30-34
32605792-7	2020	Molecular and functional studies demonstrated that the substitution of lysine (K) at position 257 with a glutamic acid (E) results in an altered IDO1 protein that undergoes a rapid protein turnover.	Lysine	71-77	indoleamine 2,3-dioxygenase 1	Homo sapiens	145-149
17077080-2	2006	Conjugation of small ubiquitin-like modifier type 1 (SUMO-1) to lysines in the negative regulatory domain strongly suppresses its transcriptional activity.	Lysine	64-71	small ubiquitin like modifier 1	Homo sapiens	53-59
17077080-5	2006	These lysines are in the negative regulatory domain of c-Myb and also serve as acceptor sites for SUMO-1.	Lysine	6-13	small ubiquitin like modifier 1	Homo sapiens	98-104
17189187-3	2006	This modification, acetylation of lysine 120 (K120), occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases hMOF and TIP60.	Lysine	34-40	lysine acetyltransferase 8	Homo sapiens	109-113
32900591-7	2020	Mass spectrophotometric analysis revealed that lysine residues in APOA1 and APOA2 of HDL modified by GAD and MDA in vitro differed from those modified by glucose, which resembled that seen with HDL from patients with type1 diabetes.	Lysine	47-53	apolipoprotein A2	Homo sapiens	76-81
33330095-0	2020	Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins.	Lysine	0-6	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	123-128
33330095-10	2020	In zebrafish, lysine in presence of E2 increased neutrophil-dependent dissemination of ER+ BC cells via upregulation of U2AF1 and RPN2 proteins, which both correlated with poor prognosis of ER+ BC patients in clinical databases.	Lysine	14-20	ribophorin II	Danio rerio	130-134
1688630-3	1990	One-half of the MAbs tested mapped to the amino-terminal proline-rich region, and one-third of the MAbs tested mapped to the lysine-arginine-rich region of tat.	Lysine	125-131	tyrosine aminotransferase	Homo sapiens	156-159
17189187-3	2006	This modification, acetylation of lysine 120 (K120), occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases hMOF and TIP60.	Lysine	34-40	lysine acetyltransferase 8	Homo sapiens	140-144
17190600-1	2006	Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established.	Lysine	8-14	crumbs cell polarity complex component 2	Homo sapiens	134-138
2108719-11	1990	The most highly cross-linked residues in TnI were Lys-105 and Lys-107, located in the inhibitory region.	Lysine	50-53	troponin I, fast skeletal muscle	Oryctolagus cuniculus	41-44
2108719-11	1990	The most highly cross-linked residues in TnI were Lys-105 and Lys-107, located in the inhibitory region.	Lysine	62-65	troponin I, fast skeletal muscle	Oryctolagus cuniculus	41-44
33256840-5	2020	Moreover, MEG3 increases the methylation modification of histone H3 at the 27th lysine via P53.	Lysine	80-86	maternally expressed 3	Homo sapiens	10-14
17154537-3	2006	We have attempted to determine the magnitude of cation-pi interactions of Lys with aromatic amino acids in four different proteins (LIVBP, MBP, RBP, and Trx).	Lysine	74-77	myelin basic protein	Homo sapiens	139-142
33244015-3	2020	DOT1L methylates lysine 79 in the globular domain of histone H3 (H3K79).	Lysine	17-23	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	0-5
2155113-6	1990	For eta = 1 cP and T = 297 K the correlation time of the labels bound to lysines is found to be tau = 9.10(-10) S and the rotational diffusion is nearly isotropic.	Lysine	73-80	endothelin receptor type A	Homo sapiens	4-7
17157253-7	2006	Consistent with the nonproteolytic self-ligase activity of Ring1B, it generates atypical mixed K6-, K27-, and K48-based polyubiquitin chains, which require the presence of all these lysine residues on the same ubiquitin molecule.	Lysine	182-188	ring finger protein 2	Homo sapiens	59-65
2117689-0	1990	Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys.	Lysine	78-81	gonadotropin releasing hormone receptor	Rattus norvegicus	21-35
33330413-2	2020	Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG aldehyde for PEGylation of the alpha-amino group of the first amino acid, and this leads to non-specific PEGylation of the epsilon amino group of lysine residues within the G-CSF; (ii) longer-acting G-CSF variants are desirable to reduce the risk of chemotherapy-associated neutropenia; and (iii) G-CSF cannot be administered on the day of chemotherapy.	Lysine	268-274	colony stimulating factor 3	Homo sapiens	11-16
33187986-6	2021	We show that acetylation of two key lysine residues on TULP3 by p300 increases TULP3 protein abundance, and that deacetylation of these sites by HDAC1 decreases protein levels.	Lysine	36-42	TUB like protein 3	Homo sapiens	55-60
17054378-2	2006	Our results suggest that the Gla 25 --&gt; Lys mutation causes a significant reduction in the binding force between protein C Gla domain and EPCR due to destabilization of the helix structure of EPCR and displacement of a Ca2+ ion.	Lysine	43-46	protein C receptor	Homo sapiens	141-145
33187986-6	2021	We show that acetylation of two key lysine residues on TULP3 by p300 increases TULP3 protein abundance, and that deacetylation of these sites by HDAC1 decreases protein levels.	Lysine	36-42	TUB like protein 3	Homo sapiens	79-84
2077397-3	1990	An IFN-alpha analogue in which arginine and lysine residues 121 and 122 were replaced by 2 leucines was generated by site-directed in vitro mutagenesis of the IFN-alpha 4 gene; at equivalent concentrations of antiviral activity, this analogue was 10-fold less effective in NK stimulation.	Lysine	44-50	interferon alpha 2	Homo sapiens	3-12
17054378-2	2006	Our results suggest that the Gla 25 --&gt; Lys mutation causes a significant reduction in the binding force between protein C Gla domain and EPCR due to destabilization of the helix structure of EPCR and displacement of a Ca2+ ion.	Lysine	43-46	protein C receptor	Homo sapiens	195-199
2360199-3	1990	Intravenous administration of the 5-HT2/5-HT1C antagonists ritanserin and LY 53857 in vivo blocked the facilitatory effects of 5-HT and DOM, but not norepinephrine (NE).	Lysine	74-76	5-hydroxytryptamine receptor 2A	Rattus norvegicus	34-39
33282879-4	2020	We demonstrate that recombinant NEDD4L stimulates ubiquitylation of OGG1 in vitro, particularly on lysine 341, and that NEDD4L and OGG1 interact in U2OS cells.	Lysine	99-105	8-oxoguanine DNA glycosylase	Homo sapiens	68-72
17030603-8	2006	The data presented here, together with our earlier data on the function of dAda2b, provide evidence that related Ada2 proteins of Drosophila, together with Gcn5 HAT, are involved in the acetylation of specific lysine residues in the N-terminal tails of nucleosomal H3 and H4.	Lysine	210-216	chromatin-binding transcription regulator ADA2	Saccharomyces cerevisiae S288C	76-80
17108113-9	2006	We show that ICAM-1 down-regulation in tumor endothelial cells is associated with ICAM-1 promoter histone H3 deacetylation and loss of histone H3 Lys(4) methylation but not with DNA hypermethylation.	Lysine	146-149	intercellular adhesion molecule 1	Mus musculus	13-19
33035707-2	2020	Chromatin immunoprecipitation (ChIP)-sequencing analyses of human adipose-derived stem cells (hADSCs) showed that hypoxia induced trimethylation of 4th lysine residue of histone 3 (H3K4me3) in the H19 gene, among the 40 known human imprinted genes, to the greatest extent.	Lysine	152-158	H19 imprinted maternally expressed transcript	Homo sapiens	197-200
33222574-8	2020	These two mutations led to the formation of a novel variant, namely Hb E-Myanmar, beta26(B8)Glu Lys and beta65(E9)Lys Asn, HBB: c.[79G>A;198G>C].	Lysine	114-117	hemoglobin subunit beta	Homo sapiens	123-126
32795465-4	2020	Our prior study identified frequent chromosome 3p loss of heterozygosity and minimum deleted regions on chromosome 3 encompassing SETD2, encoding a histone methyltransferase involved in the trimethylation of lysine-36 of histone H3 (H3K36me3).	Lysine	208-214	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	130-135
24052902-2	2013	In addition, the most commonly occurring PTMs involve similar residues in proteins such as acetylation, ubiquitylation, methylation and sumoylation at the lysine residue and phosphorylation and O-GlcNAc modification at serine/threonine residues.	Lysine	155-161	parathymosin	Homo sapiens	41-45
32952025-13	2020	A linear effect was detected for MPO, NFKB1, and SOD1 due to greater fold-change in abundance when Met was increased to reach Lys:Met ratios of 2.9:1 and 2.4:1.	Lysine	126-129	myeloperoxidase	Bos taurus	33-36
17261755-8	2006	Msk1 phosphorylates H3 at serine 10, which is followed by acetylation at lysine 14, displacement of HP1gamma, and recruitment of Brg1, PCAF, and RNA polymerase II.	Lysine	73-79	ribosomal protein S6 kinase A5	Homo sapiens	0-4
33138288-5	2020	In addition to an alteration in the epithelial-to-mesenchymal transition (EMT) marker expression, we observed PD-L1-dependent cell spreading, migration and invasion in a spheroid spreading assay on four different coatings (poly-L-lysine, collagen type I, fibronectin and Matrigel ) and a chemotactic transwell migration/invasion assay.	Lysine	223-236	CD274 molecule	Homo sapiens	110-115
20108004-4	2010	The mutation in this patient was identified in exon 12 of CFB and changes a lysine at amino acid position 533 to an arginine (c.1598A&gt;G p.Lys533Arg).	Lysine	76-82	complement factor B	Homo sapiens	58-61
17085686-10	2006	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.	Lysine	59-62	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	86-90
16374512-2	2006	In addition, the targeted acetylation of lysine (K) residues 873/874 in the carboxy-terminal region of pRb located within a cyclin-dependent kinase-docking site hinders pRb phosphorylation and thereby retains pRb in an active state of growth suppression.	Lysine	41-47	RB transcriptional corepressor 1	Homo sapiens	103-106
16374512-2	2006	In addition, the targeted acetylation of lysine (K) residues 873/874 in the carboxy-terminal region of pRb located within a cyclin-dependent kinase-docking site hinders pRb phosphorylation and thereby retains pRb in an active state of growth suppression.	Lysine	41-47	RB transcriptional corepressor 1	Homo sapiens	169-172
16374512-2	2006	In addition, the targeted acetylation of lysine (K) residues 873/874 in the carboxy-terminal region of pRb located within a cyclin-dependent kinase-docking site hinders pRb phosphorylation and thereby retains pRb in an active state of growth suppression.	Lysine	41-47	RB transcriptional corepressor 1	Homo sapiens	169-172
33109754-7	2020	CAF1 perturbation diminished occupancy of histones 3.1 and 3.3 and of repressive histone 3 lysine 9 and 27 trimethyl (H3K9me3 and H3K27me3) marks at multiple viral genome lytic cycle regulatory elements.	Lysine	91-97	chromatin assembly factor 1 subunit B	Homo sapiens	0-4
33070155-7	2020	We demonstrate that RNF40-driven H2B monoubiquitination is essential for transcriptional activation of RHO/ROCK/LIMK pathway components and proper actin-cytoskeleton dynamics through a trans-histone crosstalk with histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	224-230	H2B clustered histone 21	Homo sapiens	33-36
17085686-10	2006	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.	Lysine	59-62	histone deacetylase 1	Arabidopsis thaliana	102-105
16926075-3	2006	Polymeric core-shell microspheres with anionic functional groups on the surface were tested for their ability to reversibly bind lysine modified PNA sequences, whose antisense activity against COX-2 mRNA was already demonstrated in murine macrophages.	Lysine	129-135	cytochrome c oxidase II, mitochondrial	Mus musculus	193-198
32941003-1	2020	Sirtuin isoform 2 (SIRT2) is an enzyme that catalyzes the removal of acyl groups from lysine residues.	Lysine	86-92	sirtuin 2	Homo sapiens	0-17
32941003-1	2020	Sirtuin isoform 2 (SIRT2) is an enzyme that catalyzes the removal of acyl groups from lysine residues.	Lysine	86-92	sirtuin 2	Homo sapiens	19-24
34643933-0	2022	The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2.	Lysine	40-43	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	118-123
34974029-4	2022	We revealed that the activity of the fusion gene chimera EWSR1-FLI1, the genetic driver of Ewing sarcoma, leads to lower expression of the gene SPARC in these tumors, likely due to enriched acetylation marks of the histone H3 lysine 27 at regions including the SPARC promoter and potential enhancers.	Lysine	226-232	EWS RNA binding protein 1	Homo sapiens	57-62
16921367-4	2006	We show that these molecules directly affect the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12).	Lysine	116-122	frataxin	Homo sapiens	74-77
32915536-3	2020	Our results showed that ATP attracts multiple lysine residues of the four-repeat domain of tau (K18) via supramolecular complexation, thereby forming dimers that are converted to nuclei and accelerate fibril elongation.	Lysine	46-52	keratin 18	Homo sapiens	96-99
16857686-0	2006	Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes.	Lysine	29-35	plasminogen	Homo sapiens	64-71
33123537-1	2020	The substitution of the seventeenth amino acid glutamate by lysine in the homologous structural domain of the Akt1 gene pleckstrin is a somatic cellular mutation found in breast, colorectal, and ovarian cancers, named p. Glu17Lys or E17K.	Lysine	60-66	pleckstrin	Homo sapiens	120-130
34961760-0	2021	Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2.	Lysine	8-14	histone acetyltransferase 1	Homo sapiens	88-92
16857686-0	2006	Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes.	Lysine	29-35	plasminogen	Homo sapiens	127-134
16829524-7	2006	Comparison of the C2GnT-L structure with that of other GT-A fold glycosyltransferases further suggests that Arg-378 and Lys-401 serve to electrostatically stabilize the nucleoside diphosphate leaving group, a role normally played by metal ion in GT-A structures.	Lysine	120-123	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	18-25
34952627-8	2021	In P. oxalicum, the protein PoCyc8, a subunit of complex Tup1-Cyc8, interacts directly with TF PoCreA and histone H3 lysine 36 (H3K36) methyltransferase PoSet2 in the nucleus.	Lysine	117-123	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	57-61
34952627-8	2021	In P. oxalicum, the protein PoCyc8, a subunit of complex Tup1-Cyc8, interacts directly with TF PoCreA and histone H3 lysine 36 (H3K36) methyltransferase PoSet2 in the nucleus.	Lysine	117-123	transcription regulator CYC8	Saccharomyces cerevisiae S288C	62-66
32765868-2	2020	Triple methylation of H4 lysine 20 (H4K20me3), a key component of epigenetic regulation of genomic integrity, is catalyzed by the methyltransferase, SUV420H2.	Lysine	25-31	lysine methyltransferase 5C	Homo sapiens	149-157
32083791-4	2020	The CW domain of ASHH2 is a selective binder of monomethylation at Lysine 4 on histone H3 (H3K4me1) and likely helps the enzyme dock correctly onto chromatin sites.	Lysine	67-73	histone-lysine N-methyltransferase	Arabidopsis thaliana	17-22
32868907-4	2020	Mechanistically, we demonstrate that LSD1 positively regulates FOXA1 binding by demethylating lysine 270, adjacent to the wing2 region of the FOXA1 DNA-binding domain.	Lysine	94-100	forkhead box A1	Homo sapiens	63-68
16846981-7	2006	This topology is independently underscored by lysine mutagenesis, cell surface biotinylation, and cysteine derivation strategies and is compatible with the different physiological functions assigned to presenilin-1.	Lysine	46-52	presenilin 1	Homo sapiens	202-214
32660330-7	2020	Relative changes in the abundance of specific acetylated lysine peptides measured in DKO versus Sirt3 KO hearts were strongly correlated.	Lysine	57-63	sirtuin 3	Mus musculus	96-101
34942305-10	2022	Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis.	Lysine	261-267	lysine methyltransferase 5A	Homo sapiens	17-22
16939214-2	2006	Numerous studies revealed that this interaction occurs through the apolipoprotein(a) [apo(a)] component of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradation of fibrin with plasmin (a COOH-Lys-dependent mechanism).	Lysine	140-143	lipoprotein(a)	Homo sapiens	86-92
34801827-2	2021	In these procedure, p300/CBP could catalyze the acetylation of lysine 27 on histone 3 (H3K27ac), and had been reported to mediate tumorigenesis and development in a variety of tumors by enhancing chromatin transcription activity.	Lysine	63-69	E1A binding protein p300	Homo sapiens	20-24
34944486-1	2021	BACKGROUND: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors.	Lysine	121-127	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	12-62
33214845-1	2020	As a member of the sirtuin family of enzymes, SIRT2 promotes tumor growth and regulates various biological pathways through lysine deacetylation and defatty-acylation.	Lysine	124-130	sirtuin 2	Homo sapiens	46-51
34944486-1	2021	BACKGROUND: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors.	Lysine	121-127	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	64-69
16939214-2	2006	Numerous studies revealed that this interaction occurs through the apolipoprotein(a) [apo(a)] component of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradation of fibrin with plasmin (a COOH-Lys-dependent mechanism).	Lysine	217-220	lipoprotein(a)	Homo sapiens	67-84
32828270-5	2020	Kn2-7 enhanced the cellular uptake of CpG DNA; this effect was decreased by the substitution of arginine residues with alanine residues, and increased by the substitution of lysine residues with arginine residues.	Lysine	174-180	immunoglobulin kappa chain variable 4-70	Mus musculus	0-5
16939214-2	2006	Numerous studies revealed that this interaction occurs through the apolipoprotein(a) [apo(a)] component of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradation of fibrin with plasmin (a COOH-Lys-dependent mechanism).	Lysine	217-220	lipoprotein(a)	Homo sapiens	86-92
16939214-4	2006	Our recent study identified the Lys-independent apo(a)-binding sites within the fibrin(ogen) alphaC domains which contribute to an alternative Lys-independent mechanism.	Lysine	32-35	lipoprotein(a)	Homo sapiens	48-54
34850124-3	2021	Here, we unveil that an essential SpCas9-DNA interaction located beyond the protospacer adjacent motif (PAM) is realized through electrostatic forces between four positively charged lysines among SpCas9 residues 1151-1156 and the negatively charged DNA backbone.	Lysine	182-189	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	34-40
33088284-0	2020	Hypoxia-Inducible Lysine Methyltransferases: G9a and GLP Hypoxic Regulation, Non-histone Substrate Modification, and Pathological Relevance.	Lysine	18-24	euchromatic histone lysine methyltransferase 1	Homo sapiens	53-56
34850124-3	2021	Here, we unveil that an essential SpCas9-DNA interaction located beyond the protospacer adjacent motif (PAM) is realized through electrostatic forces between four positively charged lysines among SpCas9 residues 1151-1156 and the negatively charged DNA backbone.	Lysine	182-189	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	196-202
16939214-4	2006	Our recent study identified the Lys-independent apo(a)-binding sites within the fibrin(ogen) alphaC domains which contribute to an alternative Lys-independent mechanism.	Lysine	143-146	lipoprotein(a)	Homo sapiens	48-54
34850124-4	2021	Modulating this interaction by substituting lysines with amino acids that have distinct charges revealed a strong dependence of DNA target binding and cleavage activities of SpCas9 on the charge.	Lysine	44-51	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	174-180
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Lysine	84-90	euchromatic histone lysine methyltransferase 1	Homo sapiens	119-135
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Lysine	84-90	euchromatic histone lysine methyltransferase 1	Homo sapiens	137-140
33088284-8	2020	Furthermore, G9a and GLP elicit lysine methylation on a wide variety of non-histone proteins, many of which are known to be regulated by hypoxia.	Lysine	32-38	euchromatic histone lysine methyltransferase 1	Homo sapiens	21-24
16939214-10	2006	The experiments also identified a novel Lys-dependent high-affinity apo(a)-binding site within the sequence of gamma chain residues 287-411.	Lysine	40-43	lipoprotein(a)	Homo sapiens	68-74
16939214-11	2006	This site may provide interaction of apo(a) with intact fibrin(ogen) through another alternative mechanism, which depends on internal Lys residues.	Lysine	134-137	lipoprotein(a)	Homo sapiens	37-43
32677374-7	2020	Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells.	Lysine	146-152	lysine acetyltransferase 6A	Homo sapiens	102-107
16939214-12	2006	Thus, apo(a) may interact with intact fibrin through the Lys-independent and Lys-dependent mechanisms, while the COOH-Lys-dependent mechanism may prevail in the presence of fibrinolytic activity.	Lysine	57-60	lipoprotein(a)	Homo sapiens	6-12
34152239-2	2021	Bromodomain-containing protein 2 (BRD2) is an important member of the BET protein family, which can specifically bind histone acetylated lysine to participate in gene transcriptional regulation, chromatin remodelling, cell proliferation and apoptosis.	Lysine	137-143	bromodomain containing 2	Gallus gallus	0-32
34152239-2	2021	Bromodomain-containing protein 2 (BRD2) is an important member of the BET protein family, which can specifically bind histone acetylated lysine to participate in gene transcriptional regulation, chromatin remodelling, cell proliferation and apoptosis.	Lysine	137-143	bromodomain containing 2	Gallus gallus	34-38
16939214-12	2006	Thus, apo(a) may interact with intact fibrin through the Lys-independent and Lys-dependent mechanisms, while the COOH-Lys-dependent mechanism may prevail in the presence of fibrinolytic activity.	Lysine	77-80	lipoprotein(a)	Homo sapiens	6-12
16939214-12	2006	Thus, apo(a) may interact with intact fibrin through the Lys-independent and Lys-dependent mechanisms, while the COOH-Lys-dependent mechanism may prevail in the presence of fibrinolytic activity.	Lysine	77-80	lipoprotein(a)	Homo sapiens	6-12
33054052-0	2020	SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.	Lysine	27-33	lysine methyltransferase 2A	Homo sapiens	59-62
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Lysine	30-36	cyclin D1	Homo sapiens	166-175
32565234-0	2020	Retraction notice to "Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16" [Life Sci.	Lysine	154-160	H4 clustered histone 6	Homo sapiens	140-150
34555274-0	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.	Lysine	68-74	lysine acetyltransferase 2B	Homo sapiens	0-26
34555274-0	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.	Lysine	68-74	lysine acetyltransferase 2B	Homo sapiens	28-32
16790434-3	2006	The conformation of the PLP-amino acid adduct and its interactions with 15A9 are similar to those occurring in PLP-dependent enzymes, except that the amino acid substrate is only weakly bound, and, due to the immunization and selection strategy, the lysine residue that covalently binds PLP in these enzymes is missing.	Lysine	250-256	pyridoxal phosphatase	Homo sapiens	24-27
34555274-0	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.	Lysine	68-74	fascin actin-bundling protein 1	Homo sapiens	58-64
34555274-10	2021	RESULTS: Fascin directly interacted and colocalized with PCAF in the cytoplasm and was acetylated at lysine 471 (K471) by PCAF.	Lysine	101-107	fascin actin-bundling protein 1	Homo sapiens	9-15
34555274-10	2021	RESULTS: Fascin directly interacted and colocalized with PCAF in the cytoplasm and was acetylated at lysine 471 (K471) by PCAF.	Lysine	101-107	lysine acetyltransferase 2B	Homo sapiens	122-126
34555274-16	2021	CONCLUSIONS: Fascin interacts directly with PCAF and is acetylated at lysine 471 in ESCC cells.	Lysine	70-76	fascin actin-bundling protein 1	Homo sapiens	13-19
32514155-3	2020	Recent studies have revealed that maternal trimethylation of H3 on lysine 27 (H3K27me3) mediates autosomal maternal allele-specific gene silencing and has an important role in imprinted XCI through repression of maternal Xist.	Lysine	67-73	X inactive specific transcript	Homo sapiens	221-225
32647014-0	2020	Lysines in the lyase active site of DNA polymerase beta destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition.	Lysine	0-7	polymerase (DNA directed), beta	Mus musculus	36-55
16790434-3	2006	The conformation of the PLP-amino acid adduct and its interactions with 15A9 are similar to those occurring in PLP-dependent enzymes, except that the amino acid substrate is only weakly bound, and, due to the immunization and selection strategy, the lysine residue that covalently binds PLP in these enzymes is missing.	Lysine	250-256	pyridoxal phosphatase	Homo sapiens	111-114
16790434-3	2006	The conformation of the PLP-amino acid adduct and its interactions with 15A9 are similar to those occurring in PLP-dependent enzymes, except that the amino acid substrate is only weakly bound, and, due to the immunization and selection strategy, the lysine residue that covalently binds PLP in these enzymes is missing.	Lysine	250-256	pyridoxal phosphatase	Homo sapiens	111-114
34768127-9	2021	The acetylation level of lysine 142 in HSP90B1 was found to be obvious in the UC colon, and point mutation of HSP90B1-K142ac would result in the decreasing secretion of TNF-alpha and IL-2 in LPS-stimulated cultured cells.	Lysine	25-31	heat shock protein 90, beta (Grp94), member 1	Mus musculus	39-46
16790434-6	2006	The space vacated by the absent L-lysine side chain of the hapten can be filled, in both PLP-alanine aldimine complexes, by mobile Tyr-H100b.	Lysine	32-40	pyridoxal phosphatase	Homo sapiens	89-92
34768127-9	2021	The acetylation level of lysine 142 in HSP90B1 was found to be obvious in the UC colon, and point mutation of HSP90B1-K142ac would result in the decreasing secretion of TNF-alpha and IL-2 in LPS-stimulated cultured cells.	Lysine	25-31	heat shock protein 90, beta (Grp94), member 1	Mus musculus	110-117
32831651-11	2020	Results: Here, using a panel of OSCC cell lines with wild type or mutant p53, we show that p33ING1b expression is correlated to acetylation of p53 at lysine 382 residue.	Lysine	150-156	inhibitor of growth family member 1	Homo sapiens	91-99
16790434-9	2006	The reprotonation of C4" of PLP, the rate-limiting step of 15A9-catalyzed transamination, is most likely performed by a water molecule that, assisted by Lys-H96, produces a hydroxide ion stabilized by the anion-binding environment.	Lysine	153-156	pyridoxal phosphatase	Homo sapiens	28-31
16882982-7	2006	Our analyses of mutants that lack the PcG histone methyltransferase (HMTase) E(z) or the trxG HMTase Ash1 provide strong evidence that differential histone lysine trimethylation at the promoter and in the coding region confers transcriptional ON and OFF states of Ubx.	Lysine	156-162	Ultrabithorax	Drosophila melanogaster	264-267
32744498-4	2020	Art2 uses a basic patch to recognize C-terminal acidic sorting motifs in AATs and thereby instructs Rsp5 to ubiquitinate proximal lysine residues.	Lysine	130-136	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	100-104
34320608-6	2021	We also detected increased histone 3 lysine 9 acetylation (H3K9ac) with age at Sult1a1 (beta = 0.11, 95% CI (0.002, 0.22), SE = 0.05, P = 0.04), but no change to histone 3 lysine 27 acetylation (H3K27ac).	Lysine	37-43	sulfotransferase family 1A member 1	Homo sapiens	79-86
16714294-2	2006	The RING finger protein Ring1B is an E3 ligase that participates in the ubiquitination of lysine 119 of histone H2A, and the binding of Bmi-1 stimulates the E3 ligase activity.	Lysine	90-96	ring finger protein 2	Homo sapiens	24-30
34945726-7	2021	The KMT2C encodes a histone 3 lysine 4 (H3K4)-specific methyltransferase and involves epigenetic regulation of brain gene expression.	Lysine	30-36	lysine methyltransferase 2C	Homo sapiens	4-9
32774459-7	2020	Heterogeneity in the distribution of 5-methylcytosine and histone H3 trimethylated at lysine 9 along the chromosome axes was revealed.	Lysine	86-92	histone cluster 1 H3 family member g	Gallus gallus	58-68
16497729-0	2006	Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor.	Lysine	50-57	E1A binding protein p300	Homo sapiens	42-46
32747411-2	2020	The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3.	Lysine	111-117	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	218-221
34723504-5	2021	Besides the known site on Ycg1, we found a patch of lysines at the C-terminal domain of Ycs4 that were protected from biotinylation in the presence of DNA.	Lysine	52-59	condensin subunit YCS4	Saccharomyces cerevisiae S288C	88-92
16497729-2	2006	Using mutagenesis and mass spectrometry, we identified two conserved lysine residues in ERalpha (Lys266 and Lys268) that are the primary targets of p300-mediated acetylation.	Lysine	69-75	E1A binding protein p300	Homo sapiens	148-152
32457045-0	2020	Regulation of poly(A)-specific ribonuclease activity by reversible lysine acetylation.	Lysine	67-73	poly(A)-specific ribonuclease	Homo sapiens	14-43
16791211-4	2006	Using SUMmOn, we demonstrate for the first time that human SUMO-1 multimerizes in vitro primarily via three N-terminal lysines, Lys7, Lys16 and Lys17.	Lysine	119-126	small ubiquitin like modifier 1	Homo sapiens	59-65
32457045-6	2020	We found PARN is primarily acetylated by the acetyltransferase p300 at Lys-566 and deacetylated by sirtuin1 (SIRT1).	Lysine	71-74	poly(A)-specific ribonuclease	Homo sapiens	9-13
32470319-3	2020	Like the chromodomains of HP1 and Polycomb, the CDY chromodomains also recognize the lysine-methylated ARKS motif embedded in histone and non-histone proteins.	Lysine	85-91	chromobox 5	Homo sapiens	26-29
34772733-1	2022	Gene expression is regulated by promoters and enhancers marked by histone H3-lysine-27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HATs), EP300 and CBP.	Lysine	77-83	E1A binding protein p300	Homo sapiens	184-189
17023168-2	2006	We focused on L-lysine catabolism, and have previously demonstrated that degradation of this amino acid is osmo-regulated at the level of lysine-ketoglutarate reductase (LKR, EC 1.5.1.8) and saccharopine dehydrogenase (SDH, EC 1.5.1.9) in Brassica napus.	Lysine	14-22	alpha-aminoadipic semialdehyde synthase	Brassica napus	170-173
34762521-4	2022	The biodistribution of 67Ga-DOTA-Lys(ALB)-G/GG/GGG-Nle-CycMSHhex was examined on B16/F10 melanoma-bearing C57 mice at 2 h postinjection to select a lead peptide for further evaluation.	Lysine	33-36	albumin	Mus musculus	37-40
34762521-6	2022	Results: The IC50 value of DOTA-Lys(ALB)-G/GG/GGG-Nle-CycMSHhex {ALB-G1, ALB-G2, ALB-G3} was 0.67 +- 0.07, 0.5 +- 0.09 and 0.51 +- 0.03 nM on B16/F10 cells, respectively.	Lysine	32-35	albumin	Mus musculus	36-39
34762521-6	2022	Results: The IC50 value of DOTA-Lys(ALB)-G/GG/GGG-Nle-CycMSHhex {ALB-G1, ALB-G2, ALB-G3} was 0.67 +- 0.07, 0.5 +- 0.09 and 0.51 +- 0.03 nM on B16/F10 cells, respectively.	Lysine	32-35	albumin	Mus musculus	73-76
34762521-6	2022	Results: The IC50 value of DOTA-Lys(ALB)-G/GG/GGG-Nle-CycMSHhex {ALB-G1, ALB-G2, ALB-G3} was 0.67 +- 0.07, 0.5 +- 0.09 and 0.51 +- 0.03 nM on B16/F10 cells, respectively.	Lysine	32-35	albumin	Mus musculus	81-84
32651437-8	2020	Moreover, CCDC8 is phosphorylated at amino acid threonine T87 and serine S261, and mono-methylated at lysine K491.	Lysine	102-108	coiled-coil domain containing 8	Homo sapiens	10-15
17023168-13	2006	Collectively the results obtained demonstrate that lysine catabolism through LKR/SDH activity is involved in osmo-induced synthesis of pipecolic acid.	Lysine	51-57	alpha-aminoadipic semialdehyde synthase	Brassica napus	77-84
32435793-6	2020	Blocking ubiquitination of Smo by an E1 ligase inhibitor or by mutating two lysine residues in intracellular loop three causes Smo to aberrantly accumulate in cilia without pathway activation.	Lysine	76-82	smoothened, frizzled class receptor	Homo sapiens	127-130
34758305-4	2021	We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).	Lysine	24-30	E1A binding protein p300	Homo sapiens	49-53
34758305-4	2021	We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).	Lysine	24-30	keratin 40	Homo sapiens	70-73
16617055-6	2006	In addition, site-directed mutagenesis identified lysine 67 as the major sumoylation site on KLF8.	Lysine	50-56	Kruppel like factor 8	Homo sapiens	93-97
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	clock circadian regulator	Homo sapiens	132-137
34834780-3	2021	Arabidopsis UBC22 is a unique E2 enzyme, able to catalyze the formation of ubiquitin dimers through lysine 11 (K11).	Lysine	100-106	ubiquitin-conjugating enzyme 22	Arabidopsis thaliana	12-17
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Lysine	377-383	GDP dissociation inhibitor 1	Homo sapiens	222-226
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Lysine	238-244	DNA methyltransferase 3 beta	Homo sapiens	41-47
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Lysine	238-244	DNA methyltransferase 3 alpha	Homo sapiens	84-90
32620778-4	2020	A hydrogen bond in the catalytic loop of DNMT3B causes a lower CpG specificity than DNMT3A, while the interplay of target recognition domain and homodimeric interface fine-tunes the distinct target selection between the two enzymes, with Lysine 777 of DNMT3B acting as a unique sensor of the +1 flanking base.	Lysine	238-244	DNA methyltransferase 3 beta	Homo sapiens	252-258
32445435-0	2020	ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.	Lysine	85-91	mitogen-activated protein kinase kinase kinase 5	Mus musculus	123-127
32445435-7	2020	Mechanistically, ARRB1 directly interacts with ASK1 in hepatocytes and inhibits its TRAF6-mediated Lysine 6-linked polyubiquitination, which then prevents the activation of ASK1 and its downstream signalling pathway during hepatic I/R injury.	Lysine	99-105	mitogen-activated protein kinase kinase kinase 5	Mus musculus	47-51
16699007-9	2006	We also found immunological and radiochemical evidence that LANA is subject to lysine acetylation after NaB treatment.	Lysine	79-85	LANA	Human gammaherpesvirus 8	60-64
34592262-2	2021	One of the most well-studied protein PTMs is methylation, wherein an enzyme catalyzes the transfer of a methyl group from a cofactor to a lysine or arginine side chain.	Lysine	138-144	parathymosin	Homo sapiens	37-41
16543229-6	2006	Site-directed mutagenesis showed that Lys-253 and Lys-270, located in this sequence, were involved in internalization and subsequent vacuolar degradation of Ynt1.	Lysine	38-41	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	157-161
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	84-90	E1A binding protein p300	Homo sapiens	244-249
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	101-107	E1A binding protein p300	Homo sapiens	244-249
32306145-1	2020	Glutaric aciduria type I (GA1; OMIM #231670) is an autosomal recessively inherited and treatable disorder characterized by the accumulation and irregular excretion of glutaric acid due to a defect in the glutaryl-CoA dehydrogenase enzyme involved in the catabolic pathways of L-lysine, L-hydroxylysine, and L-tryptophan.	Lysine	276-284	glutaryl-CoA dehydrogenase	Homo sapiens	204-230
32647649-0	2020	The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1.	Lysine	12-18	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	148-153
16543229-6	2006	Site-directed mutagenesis showed that Lys-253 and Lys-270, located in this sequence, were involved in internalization and subsequent vacuolar degradation of Ynt1.	Lysine	50-53	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	157-161
16543229-8	2006	We conclude that glutamine triggers Ynt1 down-regulation via ubiquitinylation of lysines in the central hydrophilic domain, and proteolysis in the vacuole.	Lysine	81-88	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	36-40
32575755-3	2020	Both mono- and polyubiquitin were found linked to several lysine residues belonging to the region of tau protein that forms the structured core of the filaments.	Lysine	58-64	microtubule associated protein tau	Homo sapiens	101-104
16702384-8	2006	The combination genotypes of two polymorphisms revealed the clear effect of the ADH2 Arg allele among those with ALDH2 Glu/Lys in both sexes (P(trend) = 0.007 for men and 0.024 for women).	Lysine	123-126	aldehyde dehydrogenase 2 family member	Homo sapiens	113-118
32354745-4	2020	The VPA-mediated trafficking correction is in part associated with an increase in the acetylation of lysine residues in the cysteine-rich domain of NPC1.	Lysine	101-107	NPC intracellular cholesterol transporter 1	Homo sapiens	148-152
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	210-216	E1A binding protein p300	Homo sapiens	244-249
34720086-3	2021	Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine (SAM).	Lysine	86-92	phosphoglycerate dehydrogenase	Homo sapiens	18-23
34720086-3	2021	Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine (SAM).	Lysine	86-92	phosphoglycerate dehydrogenase	Homo sapiens	146-151
16648490-4	2006	We identified nine suppressors of the missense mutation clk-1(e2519), which harbors a Glu-to-Lys substitution.	Lysine	93-96	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	56-61
32400857-9	2020	The mRNA of LRP and P-gp in LY-294002 group and PDTC group were decreased.	Lysine	28-30	phosphoglycolate phosphatase	Homo sapiens	20-24
16601680-6	2006	Interestingly, we found that Tat/Brm interaction is regulated by Tat lysine 50 acetylation.	Lysine	69-75	tyrosine aminotransferase	Homo sapiens	29-32
32448279-10	2020	Further mechanistic studies revealed that EZH2 mediated trimethylation of lysine 27 on histone H3 of the KAT6B promoter.	Lysine	74-80	lysine acetyltransferase 6B	Homo sapiens	105-110
34409953-10	2021	LINC01232 epigenetically repressed the KLF2 expression via binding to enhancer of EZH2, EZH2 was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	165-171	Kruppel-like factor 2 (lung)	Mus musculus	39-43
34409953-10	2021	LINC01232 epigenetically repressed the KLF2 expression via binding to enhancer of EZH2, EZH2 was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	165-171	Kruppel-like factor 2 (lung)	Mus musculus	139-143
16601680-6	2006	Interestingly, we found that Tat/Brm interaction is regulated by Tat lysine 50 acetylation.	Lysine	69-75	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	33-36
16601680-6	2006	Interestingly, we found that Tat/Brm interaction is regulated by Tat lysine 50 acetylation.	Lysine	69-75	tyrosine aminotransferase	Homo sapiens	65-68
34909158-1	2021	Inspired by the biogenetic proposal of an intramolecular Diels-Alder (IMDA) cycloaddition, the total synthesis of natural product nahuoic acid A, a cofactor-competitive inhibitor of the epigenetic enzyme lysine methyl transferase SETD8, has been carried out.	Lysine	204-210	lysine methyltransferase 5A	Homo sapiens	230-235
32205424-5	2020	Further, using a myeloid-specific mixed-lineage leukemia 1 (MLL1) knockout (Mll1f/fLyz2Cre+ ), we determined that MLL1 drives Tlr4 expression in diabetic macrophages by regulating levels of histone H3 lysine 4 trimethylation on the Tlr4 promoter.	Lysine	201-207	lysine methyltransferase 2A	Homo sapiens	114-118
16533895-0	2006	A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.	Lysine	51-57	cyclic nucleotide gated channel subunit alpha 2	Homo sapiens	115-120
32358498-1	2020	Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation.	Lysine	26-32	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	45-49
34745943-4	2021	In this study, the results showed that LukS-PV induced apoptosis by downregulating the methyltransferase SET8 and its target histone H4 monomethylated at Lys 20 (H4K20me1).	Lysine	154-157	lysine methyltransferase 5A	Homo sapiens	105-109
34644302-4	2021	Here, we mapped the known SIRT3/SIRT5-targeted lysine residues onto the recently solved TFP crystal structure which revealed that many of the target sites are involved in substrate channeling within the TFPalpha subunit.	Lysine	47-53	sirtuin 5	Mus musculus	32-37
16537902-1	2006	The chromodomain (CD) of the Drosophila Polycomb protein exhibits preferential binding affinity for histone H3 when trimethylated at lysine 27.	Lysine	133-139	Polycomb	Drosophila melanogaster	40-48
16581778-3	2006	This selection identified mutations in SET2, which encodes a histone methylase that targets lysine 36 of histone H3 and, like BUR1, has a poorly characterized role during transcription elongation.	Lysine	92-98	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	39-43
32341358-3	2020	Here we show that RNF40, a histone H2B lysine 120 E3 ubiquitin-protein ligase, is specifically required for early reprogramming during induced pluripotency.	Lysine	39-45	H2B clustered histone 21	Homo sapiens	35-38
32357443-1	2020	CREB-binding protein (p300/CBP) is a universal transcriptional co-regulator with lysine acetyltransferase activity.	Lysine	81-87	sarcoplasmic calcium-binding protein	Drosophila melanogaster	27-30
34216208-0	2021	tRNA-derived fragment tRF Lys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC.	Lysine	26-29	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	126-130
34216208-9	2021	Thus, fine-tuneing glucose metabolism and the tRF Lys-CTT-010 /G6PC axis may provide a therapeutic target for TNBC treatment.	Lysine	50-53	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	63-67
16581778-5	2006	This SET2-dependent growth inhibition occurs via methylation of histone H3 on lysine 36, since a methylation-defective allele of SET2 or a histone H3 K36R mutation also suppressed bur1Delta.	Lysine	78-84	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	5-9
16501569-4	2006	CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck.	Lysine	23-26	CYLD lysine 63 deubiquitinase	Mus musculus	0-4
32324495-3	2020	The BETs (bromodomain and extraterminal-containing protein family), which includes BRD2, BRD3, and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetylated lysine residues on histone tails where they facilitate the assembly of transcription complexes including transcription factors and transcriptional machinery like RNA Polymerase II.	Lysine	200-206	bromodomain testis associated	Homo sapiens	130-134
32176478-1	2020	ENL is a transcriptional coactivator that recruits elongation machinery to active cis-regulatory elements upon binding of its YEATS domain-a chromatin reader module-to acylated lysine side chains.	Lysine	177-183	MLLT1 super elongation complex subunit	Homo sapiens	0-3
16501569-4	2006	CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck.	Lysine	23-26	lymphocyte protein tyrosine kinase	Mus musculus	75-78
34319621-5	2021	In cooperation with NFRs, the histone variant H2A.Z facilitates ORC loading through di-methylation of lysine 20 of histone H4.	Lysine	102-108	histone H4	Saccharomyces cerevisiae S288C	115-125
16501569-4	2006	CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck.	Lysine	35-38	CYLD lysine 63 deubiquitinase	Mus musculus	0-4
16501569-4	2006	CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck.	Lysine	35-38	lymphocyte protein tyrosine kinase	Mus musculus	75-78
16254126-7	2006	A synthetic tripalmitoylated cysteine-, serine-, and lysine-containing peptide (Pam) and LPS from Porphyromonas gingivalis, two TLR2 ligands, also stimulated IL-6 expression.	Lysine	53-59	peptidylglycine alpha-amidating monooxygenase	Mus musculus	80-83
34303036-0	2021	Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9.	Lysine	21-27	matrix metallopeptidase 2	Homo sapiens	98-103
34303036-6	2021	The synthesized biphenyl substituted lysine derivatives showed IC50-values in the low nanomolar concentration range against MMP-2 (ligands 3a-d: 3 nM to 8 microM, ligands 4a-d: 45 nM to 350 microM) and low micromolar range against MMP-9 (ligands 3a-d: 350 nM to 60 microM, ligands 4a-d: 5 microM to 600 microM), with a selectivity up to more than 160-fold for MMP-2.	Lysine	37-43	matrix metallopeptidase 2	Homo sapiens	124-129
34303036-6	2021	The synthesized biphenyl substituted lysine derivatives showed IC50-values in the low nanomolar concentration range against MMP-2 (ligands 3a-d: 3 nM to 8 microM, ligands 4a-d: 45 nM to 350 microM) and low micromolar range against MMP-9 (ligands 3a-d: 350 nM to 60 microM, ligands 4a-d: 5 microM to 600 microM), with a selectivity up to more than 160-fold for MMP-2.	Lysine	37-43	matrix metallopeptidase 2	Homo sapiens	360-365
32141187-3	2020	Here, we further investigate the function of IDH1 hyperacetylation at lysine 224 in CRC progression.	Lysine	70-76	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	45-49
32350470-7	2020	SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16.	Lysine	129-135	H4 clustered histone 6	Homo sapiens	96-106
16501224-6	2006	In consistent fashion, TUG-UBL1 is not expected to participate in a covalent protein modification reaction as it lacks the characteristic C-terminal diglycine ("GG") motif required for conjugation to an acceptor lysine, and also lacks the three most common acceptor lysine residues involved in polyubiquitination.	Lysine	212-218	small ubiquitin like modifier 1	Homo sapiens	27-31
34473995-5	2021	Here we demonstrate that the BD of Caenorhabditis elegans SMARCA4/BRG1, a core SWI/SNF subunit, recognizes acetylated lysine 14 of histone H3 (H3K14ac), similar to its Homo sapiens ortholog.	Lysine	118-124	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	58-65
16501224-6	2006	In consistent fashion, TUG-UBL1 is not expected to participate in a covalent protein modification reaction as it lacks the characteristic C-terminal diglycine ("GG") motif required for conjugation to an acceptor lysine, and also lacks the three most common acceptor lysine residues involved in polyubiquitination.	Lysine	266-272	small ubiquitin like modifier 1	Homo sapiens	27-31
34560100-2	2021	The polyamines putrescine, agmatine and cadaverine, are produced by pyridoxal 5"-phosphate-dependent L-ornithine, L-arginine and L-lysine decarboxylases (ODC, ADC, LDC), respectively, from both the alanine racemase (AR) and aspartate aminotransferase (AAT) folds.	Lysine	129-137	ornithine decarboxylase 1	Homo sapiens	154-157
32235505-2	2020	DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine spermidine to a specific lysine of eukaryotic translation factor 5A (eIF5A) precursor in a nicotinamide adenine dinucleotide (NAD)-dependent manner.	Lysine	90-96	eukaryotic translation initiation factor 5A	Homo sapiens	100-132
32235505-2	2020	DHS catalyses the transfer of a 4-aminobutyl moiety of polyamine spermidine to a specific lysine of eukaryotic translation factor 5A (eIF5A) precursor in a nicotinamide adenine dinucleotide (NAD)-dependent manner.	Lysine	90-96	eukaryotic translation initiation factor 5A	Homo sapiens	134-139
16476846-2	2006	The amino acid sequence of PLN is highly conserved, and although all species contain asparagine (Asn), human PLN is unique in containing lysine (Lys) at amino acid 27.	Lysine	137-143	phospholamban	Homo sapiens	109-112
32202502-5	2020	We identified lysine (K)270 as a target regulating RANKL signaling as K270A substitution results in exuberant osteoclastogenesis in vitro and murine inflammatory osteolysis in vivo.	Lysine	14-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	51-56
34396440-3	2021	The inhibition of WNK lysine deficient protein kinase/STE20/SPS1-related proline/alanine-rich kinase (SPAK) signaling ameliorates cerebral edema, and this signaling pathway regulates the phosphorylation of the downstream Na+-K+-Cl- cotransporter 1 (NKCC1).	Lysine	22-28	solute carrier family 12 member 2	Rattus norvegicus	221-247
16476846-2	2006	The amino acid sequence of PLN is highly conserved, and although all species contain asparagine (Asn), human PLN is unique in containing lysine (Lys) at amino acid 27.	Lysine	145-148	phospholamban	Homo sapiens	109-112
16356930-6	2006	Subsequent to the catalysis of acetyltransfer to lysine 8 of histone H4 for the enzyme, however, the substrate is released and NCOAT can no longer bind H4 in our assays.	Lysine	49-55	O-GlcNAcase	Homo sapiens	127-132
34616852-8	2021	The mechanism of action involves preventing HMGB1"s hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1.	Lysine	81-87	high mobility group box 1	Mus musculus	44-49
34556767-2	2021	Though there are several computational tools to identify individual PTMs, only three predictors have been established to predict multiple PTMs at the same lysine residue.	Lysine	155-161	parathymosin	Homo sapiens	68-72
32391426-3	2020	We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.	Lysine	53-59	glutaminase	Homo sapiens	16-27
32391426-3	2020	We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.	Lysine	53-59	glutaminase	Homo sapiens	29-32
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	119-125	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-103
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	178-184	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-103
16356933-4	2006	Adjacent to the sumoylation motif is Ser-444, which like Lys-439 is highly conserved among MEF2 proteins from diverse species.	Lysine	57-60	myocyte enhancer factor 2A	Homo sapiens	91-95
16356938-7	2006	Our results show that these Lys residues are acetylated by the nuclear acetylase p300.	Lysine	28-31	E1A binding protein p300	Homo sapiens	81-85
16460033-1	2006	In the present study we investigated the role of factor XIIIa reactive Gln and Lys sites of staphylococcal FnbA receptor in cross-linking reaction with alpha chains of fibrin.	Lysine	79-82	AT695_RS04810	Staphylococcus aureus	107-111
32129764-4	2020	We demonstrate that USP16 constitutes a component of late cytoplasmic pre-40S subunits that promotes the removal of ubiquitin from an internal lysine of ribosomal protein RPS27a/eS31.	Lysine	143-149	ubiquitin specific peptidase 16	Homo sapiens	20-25
32129764-4	2020	We demonstrate that USP16 constitutes a component of late cytoplasmic pre-40S subunits that promotes the removal of ubiquitin from an internal lysine of ribosomal protein RPS27a/eS31.	Lysine	143-149	ribosomal protein S27a	Homo sapiens	171-177
34556767-2	2021	Though there are several computational tools to identify individual PTMs, only three predictors have been established to predict multiple PTMs at the same lysine residue.	Lysine	155-161	parathymosin	Homo sapiens	138-142
16460035-5	2006	Mapping of the epitope of the antibody through the use of recombinant protein constructs and phage display showed that the epitope for GC-C:4D7 lies immediately C-terminal to a critical lysine residue (Lys516 in GC-C), required for ATP interaction in protein kinases.	Lysine	186-192	guanylate cyclase 2C	Homo sapiens	135-139
34530900-4	2021	RESULTS: Here, we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for the mono-methylation of histone H4 at lysine 20, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.	Lysine	55-61	lysine methyltransferase 5A	Homo sapiens	80-85
34530900-4	2021	RESULTS: Here, we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for the mono-methylation of histone H4 at lysine 20, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.	Lysine	150-156	lysine methyltransferase 5A	Homo sapiens	80-85
31922235-5	2020	The results indicated that BRD4 binds to enhancers with histone H3 acetylated at lysine 27 (H3K27Ac) and mediator complex subunit 1 in a cell type-specific manner, as well as binds to promoter regions with the oncogenic TFs MYC and E2F1 in a cell type-common manner.	Lysine	81-87	bromodomain containing 4 L homeolog	Xenopus laevis	27-31
16376303-1	2006	Mouse ARD1 (mARD1) has been reported to negatively regulate the hypoxia-inducible factor 1alpha (HIF-1alpha) protein by acetylating a lysine residue and enhancing HIF-1alpha ubiquitination and degradation.	Lysine	134-140	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	6-10
31996376-5	2020	Down syndrome critical region gene 6 (DSCR6), a RIPPLY family member that induces dorsal mesoderm by releasing repressive polycomb group proteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional and ventralizing activities by interfering with its lysine methylation.	Lysine	287-293	signal transducer and activator of transcription 3, gene 1 L homeolog	Xenopus laevis	175-180
31996376-8	2020	Furthermore, interference with Ezh2 phosphorylation also prevented Stat3 lysine methylation and transcriptional activity.	Lysine	73-79	signal transducer and activator of transcription 3, gene 1 L homeolog	Xenopus laevis	67-72
31996376-9	2020	Thus, inhibition of either Ezh2 phosphorylation or Stat3 lysine methylation compensated for the absence of DSCR6 function.	Lysine	57-63	signal transducer and activator of transcription 3, gene 1 L homeolog	Xenopus laevis	51-56
34530900-6	2021	Indeed, the inhibition of SETD8 by the chemical compound UNC-0379 and the subsequent decrease in histone H4 methylation at lysine 20 are highly toxic in MM cells compared to normal cells from the bone marrow microenvironment.	Lysine	123-129	lysine methyltransferase 5A	Homo sapiens	26-31
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	RAP1 GTPase activating protein	Homo sapiens	40-47
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	RAP1 GTPase activating protein	Homo sapiens	153-160
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	RAP1 GTPase activating protein	Homo sapiens	247-254
16384625-1	2006	The SU(VAR)3-9 protein family was first identified in animals as heterochromatin-associated proteins and found to control establishment of heterochromatic chromatin domains by histone H3 lysine 9 methylation.	Lysine	187-193	zinc finger (Ran-binding) family protein	Arabidopsis thaliana	4-14
34289383-0	2021	Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.	Lysine	0-6	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	36-40
31875226-5	2020	STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha1, the beta1-beta2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha2 bind to the phosphodiester backbone from the major groove side.	Lysine	195-202	staufen double-stranded RNA binding protein 1	Homo sapiens	0-5
32296036-7	2020	Finally, we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.	Lysine	91-97	sirtuin 3	Rattus norvegicus	30-35
34271259-1	2021	The NSD proteins, namely NSD1, NSD2 and NSD3, are lysine methyltransferases, which catalyze mono- and di-methylation of histone H3K36.	Lysine	50-56	nuclear receptor binding SET domain protein 1	Homo sapiens	25-29
34271259-1	2021	The NSD proteins, namely NSD1, NSD2 and NSD3, are lysine methyltransferases, which catalyze mono- and di-methylation of histone H3K36.	Lysine	50-56	nuclear receptor binding SET domain protein 3	Homo sapiens	40-44
16329992-5	2006	We found that like other genes, Tup1-Ssn6 target genes exhibit increased levels of histone H3 lysine 4 trimethylation upon activation.	Lysine	94-100	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	32-36
32120841-0	2020	Isoform-Specific Lysine Methylation of RORalpha2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression.	Lysine	17-23	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	52-57
32103017-3	2020	They modify ADP-ribosylation factor 6 (ARF6) on lysine 3 allowing it to remain on membranes during the GTPase cycle.	Lysine	48-54	ADP ribosylation factor 6	Homo sapiens	12-37
16329992-5	2006	We found that like other genes, Tup1-Ssn6 target genes exhibit increased levels of histone H3 lysine 4 trimethylation upon activation.	Lysine	94-100	transcription regulator CYC8	Saccharomyces cerevisiae S288C	37-41
32103017-3	2020	They modify ADP-ribosylation factor 6 (ARF6) on lysine 3 allowing it to remain on membranes during the GTPase cycle.	Lysine	48-54	ADP ribosylation factor 6	Homo sapiens	39-43
34496098-10	2021	LP+0.3% Lys group attenuated the effects of LP diet on the expression of MSTN, WWP1, IGF1, P-P70S6K1, P-4EBP1 and P-S6 (p < 0.05).	Lysine	8-11	NEDD4-like E3 ubiquitin-protein ligase WWP1	Oryctolagus cuniculus	79-83
16582543-8	2006	Moreover, homozygous carriers of both ET-1 and ET(A) variants showed a marked increase in the risk of HF (adjusted OR = 8.6, p = 0.005), displayed significantly lower LVEF (p = 0.002) and higher left ventricular end-diastolic (p = 0.03) and end-systolic diameters (p = 0.04; for Asn/Asn and TT vs. Lys and C carriers of the ET-1 and ET(A )polymorphisms, respectively).	Lysine	298-301	endothelin receptor type A	Homo sapiens	47-51
34496098-11	2021	LP+0.3% Lys group resulted in an increase in mRNA expression of MyoD and protein expression of P-mTOR relative to the NP and LP groups (p < 0.05).	Lysine	8-11	serine/threonine-protein kinase mTOR	Oryctolagus cuniculus	97-101
16563226-4	2006	In this study, we demonstrate that MEF2A undergoes sumoylation primarily at a single lysine residue (K395) both in vitro and in vivo.	Lysine	85-91	myocyte enhancer factor 2A	Homo sapiens	35-40
34482814-6	2021	The cpl1-3 mutant contains a G-to-A transition in the second exon, which results in an amino acid substitution from Glu to Lys (E116K).	Lysine	123-126	C-terminal domain phosphatase-like 1	Arabidopsis thaliana	4-10
32093151-2	2020	WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored.	Lysine	40-46	WNK lysine deficient protein kinase 2	Homo sapiens	0-4
16354696-5	2006	However, depletion of Paf1 reduces trimethylation of histone H3 at lysine 4 in the Hsp70 promoter region and significantly decreases the recruitment of chromatin-associated factors Spt6 and FACT, suggesting that Paf1 may manifest its effects on transcription through modulating chromatin structure.	Lysine	67-73	Heat-shock-protein-70Ab	Drosophila melanogaster	83-88
31759822-3	2020	Upon serum deprivation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox Protein (ADNP) and located near cell-cycle genes recruits TFIIIC, which alters their chromatin accessibility by direct acetylation of histone H3 lysine-18 (H3K18).	Lysine	246-252	activity dependent neuroprotector homeobox	Homo sapiens	58-108
31759822-3	2020	Upon serum deprivation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox Protein (ADNP) and located near cell-cycle genes recruits TFIIIC, which alters their chromatin accessibility by direct acetylation of histone H3 lysine-18 (H3K18).	Lysine	246-252	activity dependent neuroprotector homeobox	Homo sapiens	110-114
34264285-0	2021	Tubulin methylation of lysine 40 by SETD2: a new way to tune neuronal functions?	Lysine	23-29	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	36-41
16263726-0	2005	Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.	Lysine	84-90	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	20-24
34342229-5	2021	These KCTD proteins promote monoubiquitination of lysine-23 within Gbeta1/2 in vitro and in HEK-293 cells.	Lysine	50-56	electron transfer flavoprotein subunit alpha	Homo sapiens	67-75
34342229-7	2021	Together, our studies suggest that a KCTD2-KCTD5-CUL3-RING E3 ligase recruits Gbetagamma in response to signaling, monoubiquitinates lysine-23 within Gbeta1/2, and regulates Gbetagamma effectors to modulate downstream signal transduction.	Lysine	133-139	potassium channel tetramerization domain containing 2	Homo sapiens	37-42
31732298-5	2020	Notably, miR24-2 inhibits histone deacetylase HDAC3 through miR675, which promotes the acetylation of histone H4 at lysine 16.	Lysine	116-122	microRNA 24-2	Homo sapiens	9-16
31732298-5	2020	Notably, miR24-2 inhibits histone deacetylase HDAC3 through miR675, which promotes the acetylation of histone H4 at lysine 16.	Lysine	116-122	H4 clustered histone 6	Homo sapiens	102-112
34342229-7	2021	Together, our studies suggest that a KCTD2-KCTD5-CUL3-RING E3 ligase recruits Gbetagamma in response to signaling, monoubiquitinates lysine-23 within Gbeta1/2, and regulates Gbetagamma effectors to modulate downstream signal transduction.	Lysine	133-139	cullin 3	Homo sapiens	49-53
16263726-2	2005	In the current study, we identify human CHD1, an ATP-dependent chromatin remodeling protein, as a factor that directly and selectively recognizes histone H3 methylated on lysine 4.	Lysine	171-177	chromodomain helicase DNA binding protein 1	Homo sapiens	40-44
34342229-7	2021	Together, our studies suggest that a KCTD2-KCTD5-CUL3-RING E3 ligase recruits Gbetagamma in response to signaling, monoubiquitinates lysine-23 within Gbeta1/2, and regulates Gbetagamma effectors to modulate downstream signal transduction.	Lysine	133-139	electron transfer flavoprotein subunit alpha	Homo sapiens	150-158
16344468-1	2005	In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating cell nuclear antigen (PCNA) at Lys-164.	Lysine	157-160	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	112-146
31287209-3	2020	MALDI-TOF MS experiments reveal that, unlike monomethyltransferases SETD7 and SETD8, methyltransferases G9a and G9a-like protein (GLP) do have the capacity to ethylate lysine residues in histone peptides, and that cosubstrates follow the efficiency trend AdoMet>AdoSeEth>AdoEth.	Lysine	168-174	euchromatic histone lysine methyltransferase 1	Homo sapiens	112-128
31287209-3	2020	MALDI-TOF MS experiments reveal that, unlike monomethyltransferases SETD7 and SETD8, methyltransferases G9a and G9a-like protein (GLP) do have the capacity to ethylate lysine residues in histone peptides, and that cosubstrates follow the efficiency trend AdoMet>AdoSeEth>AdoEth.	Lysine	168-174	euchromatic histone lysine methyltransferase 1	Homo sapiens	130-133
31287209-4	2020	G9a and GLP can also catalyze AdoSeEth-mediated ethylation of ornithine and produce histone peptides bearing lysine residues with different alkyl groups, such as H3K9meet and H3K9me2et.	Lysine	109-115	euchromatic histone lysine methyltransferase 1	Homo sapiens	8-11
34085165-7	2021	In addition, incubation of  2-HDE with rHDAC1 generated five different amino acid adducts as detected by LC-MS/MS; the predominant adduct being  2-HDE with lysine residues of HDAC1.	Lysine	156-162	histone deacetylase 1	Rattus norvegicus	39-45
16344468-1	2005	In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating cell nuclear antigen (PCNA) at Lys-164.	Lysine	157-160	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	148-152
31981571-13	2020	CONCLUSIONS: Our results indicate for the first time that mimicking acetylation of a specific cTnI lysine accelerates myofilament, myofibril, and myocyte relaxation.	Lysine	99-105	troponin I3, cardiac type	Rattus norvegicus	94-98
16344468-3	2005	Here, we describe a robust in vitro system that ubiquitinates yeast PCNA specifically on Lys-164.	Lysine	89-92	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	68-72
16380505-5	2005	We show that BMP-2 induces the phosphorylation of mTOR in A549 and H1299 lung cancer cell lines, which is attenuated by the PI3K antagonists LY-294002 and wortmannin.	Lysine	141-143	bone morphogenetic protein 2	Homo sapiens	13-18
31755685-2	2020	Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodomain (ChD).	Lysine	157-163	chromobox 4	Homo sapiens	45-49
31755685-2	2020	Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodomain (ChD).	Lysine	157-163	chromobox 7	Homo sapiens	57-61
34358562-1	2021	Protein acetylation is a reversible post-translational modification, which is regulated by lysine acetyltransferase (KAT) and lysine deacetyltransferase (KDAC).	Lysine	91-97	thiosulfate sulfurtransferase (rhodanese)-like domain containing 1	Mus musculus	117-120
16307304-5	2005	Treatment of sulfite reductase with the lysine-modifying reagent, N-acetylsuccinimide, inhibited the ferredoxin-linked activity of the enzyme without inhibiting the methyl viologen-linked activity.	Lysine	40-46	ferredoxin	Zea mays	101-111
31755685-2	2020	Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodomain (ChD).	Lysine	157-163	chromobox 8	Homo sapiens	67-71
16307304-9	2005	The effects of these three inhibitory treatments are consistent with a possible role for a tryptophan residue the catalytic mechanism of sulfite reductase and for lysine and arginine residues at the ferredoxin-binding site of the enzyme.	Lysine	163-169	ferredoxin	Zea mays	199-209
34400522-9	2021	Keap1 was required for viral induction of G9a-GLP lysine methyltransferase binding and H3K9me2 modification at cytokine genes.	Lysine	50-56	euchromatic histone lysine N-methyltransferase 2	Mus musculus	42-45
31744885-9	2020	Mechanistically, SIRT6 bound to and repressed the expression of key TGF-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone 3.	Lysine	143-146	transforming growth factor alpha	Mus musculus	68-76
16150736-5	2005	A site-directed mutation at Lys-1016 significantly decreased WRN binding to fork or bubble DNA substrates.	Lysine	28-31	WRN RecQ like helicase	Homo sapiens	61-64
31744885-9	2020	Mechanistically, SIRT6 bound to and repressed the expression of key TGF-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone 3.	Lysine	153-156	transforming growth factor alpha	Mus musculus	68-76
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	serpin family E member 1	Homo sapiens	25-30
34429416-5	2021	Within the CBS, ATPase coupling is mediated by the charge distribution between an aspartate and a lysine.	Lysine	98-104	dynein axonemal heavy chain 8	Homo sapiens	16-22
16150736-6	2005	Moreover, the Lys-1016 mutation markedly reduced WRN helicase activity on fork, D-loop, and Holliday junction substrates in addition to reducing significantly the ability of WRN to stimulate FEN-1 incision activities.	Lysine	14-17	WRN RecQ like helicase	Homo sapiens	49-52
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	serpin family E member 1	Homo sapiens	88-93
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	serpin family E member 1	Homo sapiens	88-93
34419497-3	2021	We found that AKT transcription signaling was a target pathway via miR-26a-mediated deacetylation modification of Ras-responsive element-binding protein 1 (RREB1) at the Lys-60 residue.	Lysine	170-173	microRNA 26a-1	Homo sapiens	67-74
16150736-6	2005	Moreover, the Lys-1016 mutation markedly reduced WRN helicase activity on fork, D-loop, and Holliday junction substrates in addition to reducing significantly the ability of WRN to stimulate FEN-1 incision activities.	Lysine	14-17	WRN RecQ like helicase	Homo sapiens	174-177
31792055-5	2020	Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1.	Lysine	69-75	serpin family E member 1	Homo sapiens	88-93
31792055-9	2020	Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.	Lysine	155-158	serpin family E member 1	Homo sapiens	106-111
16262255-4	2005	Little is known about how SCF(Skp2) recruits its substrates and selects particular acceptor lysine residues for ubiquitination.	Lysine	92-98	S-phase kinase associated protein 2	Homo sapiens	30-34
31792055-9	2020	Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.	Lysine	155-158	serpin family E member 1	Homo sapiens	185-190
31792055-9	2020	Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.	Lysine	155-158	serpin family E member 1	Homo sapiens	185-190
34400610-4	2021	In normal mammary gland epithelial cells glucose can promote the nuclear translocation of SerRS by increasing the acetylation of SerRS at lysine 323.	Lysine	138-144	seryl-aminoacyl-tRNA synthetase 2	Mus musculus	90-95
16262255-5	2005	In this study, we investigated the requirements for SCF(Skp2) recognition of p21(Cip1/WAF1) and lysine residues that are ubiquitinated in vitro and inside cells.	Lysine	96-102	S-phase kinase associated protein 2	Homo sapiens	56-60
15944210-10	2005	Rapid ERK1/2 activation that preceded FAK and paxillin activation was detected upon VSM cell adhesion to poly-l-lysine, and this response was inhibited by CaMKII gene silencing.	Lysine	105-118	protein tyrosine kinase 2	Homo sapiens	38-41
34440566-0	2021	Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase.	Lysine	61-67	lysine methyltransferase 2B	Homo sapiens	40-44
34440566-0	2021	Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase.	Lysine	61-67	lysine methyltransferase 2B	Homo sapiens	46-51
31491587-1	2020	Glutaric Aciduria Type I (GA-I), is an autosomal recessive neurometabolic disease caused by mutations in the GCDH gene that encodes for glutaryl-CoA dehydrogenase (GCDH), a flavoprotein involved in the metabolism of tryptophan, lysine and hydroxylysine.	Lysine	228-234	glutaryl-CoA dehydrogenase	Homo sapiens	109-113
31491587-1	2020	Glutaric Aciduria Type I (GA-I), is an autosomal recessive neurometabolic disease caused by mutations in the GCDH gene that encodes for glutaryl-CoA dehydrogenase (GCDH), a flavoprotein involved in the metabolism of tryptophan, lysine and hydroxylysine.	Lysine	228-234	glutaryl-CoA dehydrogenase	Homo sapiens	136-162
31491587-1	2020	Glutaric Aciduria Type I (GA-I), is an autosomal recessive neurometabolic disease caused by mutations in the GCDH gene that encodes for glutaryl-CoA dehydrogenase (GCDH), a flavoprotein involved in the metabolism of tryptophan, lysine and hydroxylysine.	Lysine	228-234	glutaryl-CoA dehydrogenase	Homo sapiens	164-168
15944210-10	2005	Rapid ERK1/2 activation that preceded FAK and paxillin activation was detected upon VSM cell adhesion to poly-l-lysine, and this response was inhibited by CaMKII gene silencing.	Lysine	105-118	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	155-161
16237090-3	2005	In human peripheral blood NK cells and long-term cell lines, expressed KIR genes were associated with a moderate level of acetylated histone H3 and H4 and trimethylated histone H3 lysine 4.	Lysine	180-186	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	71-74
33389883-8	2020	Tregs uniquely constitutively express an E3 ligase known as the gene related to anergy in lymphocytes (GRAIL), which ubiquinates the exact lysine on the Cul5 protein that needs to be neddylated as a condition for the activation and consequent ubiquitination of pJAKl.	Lysine	139-145	cullin 5	Homo sapiens	153-157
34255515-1	2021	CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development.	Lysine	55-61	E1A binding protein p300	Homo sapiens	37-42
34255515-1	2021	CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development.	Lysine	55-61	E1A binding protein p300	Homo sapiens	44-49
34255515-3	2021	The bromodomains of CREBBP and EP300 enable the binding of acetylated lysine residues from histones and a number of other important proteins, including p53, p73, E2F, and GATA1.	Lysine	70-76	E1A binding protein p300	Homo sapiens	31-36
34255515-3	2021	The bromodomains of CREBBP and EP300 enable the binding of acetylated lysine residues from histones and a number of other important proteins, including p53, p73, E2F, and GATA1.	Lysine	70-76	tumor protein p73	Homo sapiens	157-160
31132972-1	2020	Mixed Lineage Leukemia 1 (MLL1), an important member of Histone Methyltransferases (HMT) family, is capable of catalyzing mono-, di-, and trimethylation of Histone 3 lysine 4 (H3K4).	Lysine	166-172	lysine methyltransferase 2A	Homo sapiens	0-24
31132972-1	2020	Mixed Lineage Leukemia 1 (MLL1), an important member of Histone Methyltransferases (HMT) family, is capable of catalyzing mono-, di-, and trimethylation of Histone 3 lysine 4 (H3K4).	Lysine	166-172	lysine methyltransferase 2A	Homo sapiens	26-30
16227571-0	2005	A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.	Lysine	126-132	male-specific lethal 3	Drosophila melanogaster	53-56
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Lysine	21-27	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	90-95
34356675-1	2021	The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines.	Lysine	125-131	lysine methyltransferase 2C	Homo sapiens	32-36
16363234-8	2005	A molecular dynamics simulation of Gla 25--&gt;Lys/EPCR complex in water suggested that the affinity between the molecules was decreased compared to the wild type Gla domain/EPCR complex.	Lysine	47-50	protein C receptor	Homo sapiens	51-55
34270461-7	2021	Mechanically, upon interaction with p53, BMI1 was recruited on the promoter of miR-3682-3p gene concomitant with an increase in the mono-ubiquitination of histone H2A lysine 119, leading to transcription repression of miR-3682-3p gene followed by derepression of ABCB1 (ATP binding cassette subfamily B member 1) gene.	Lysine	167-173	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	41-45
34357075-0	2021	Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases.	Lysine	68-74	SUV39H2 histone lysine methyltransferase	Homo sapiens	52-59
34357075-1	2021	SUV39H1 and SUV39H2 were the first protein lysine methyltransferases that were identified more than 20 years ago.	Lysine	43-49	SUV39H2 histone lysine methyltransferase	Homo sapiens	12-19
31587141-1	2019	BACKGROUND: Kabuki syndrome (KS), is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase (KMT2D) or an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A).	Lysine	110-116	lysine methyltransferase 2D	Homo sapiens	130-135
31515273-3	2019	Circadian acetylation of Lys-537 within the G-region enhances repressive BMAL1-TAD-CRY1 interactions.	Lysine	25-28	cryptochrome circadian regulator 1	Homo sapiens	83-87
16363234-8	2005	A molecular dynamics simulation of Gla 25--&gt;Lys/EPCR complex in water suggested that the affinity between the molecules was decreased compared to the wild type Gla domain/EPCR complex.	Lysine	47-50	protein C receptor	Homo sapiens	174-178
16363234-9	2005	Since Gla 25 has been shown to play an important role in protein C function, not only in membrane phospholipid binding but also in binding to EPCR, our findings provide new insight into the mechanism by which the Glu 25--&gt;Lys mutation induces type IIb protein C deficiency in individuals.	Lysine	225-228	protein C receptor	Homo sapiens	142-146
34367411-2	2021	We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues.	Lysine	147-153	small ubiquitin like modifier 1	Homo sapiens	87-118
31330113-8	2019	Co-immunoprecipitation analysis indicated that Ti particles promoted the binding of Brd4 to acetylated NF-kappaB p65 (lysine-310), which was also abrogated in JQ1-treated RAW264.7 cells.	Lysine	118-124	bromodomain containing 4	Mus musculus	84-88
34367411-2	2021	We demonstrate that ETV1 can be posttranslationally modified by covalent attachment of small ubiquitin-like modifier 1 (SUMO1) onto four different lysine residues.	Lysine	147-153	small ubiquitin like modifier 1	Homo sapiens	120-125
16396320-3	2005	Analysis of LMP7 gene polymorphism has shown that Lys/Lys - 89.5 %, Lys/Gln - 10.5 %, Gin/Gin - 0 % (in control group 93.8, 6.2, 0 % correspondingly; P &gt; 0.05).	Lysine	50-53	proteasome 20S subunit beta 8	Homo sapiens	12-16
34244565-5	2021	Reciprocally, SIRT6 also deacetylated CDH1 at lysine K135 and promoted its degradation, resulting in an increase in APC/C-CDH1-targeted substrates, dysfunction in centrosome amplification, and chromosome instability.	Lysine	46-52	sirtuin 6	Homo sapiens	14-19
34156114-5	2021	More importantly, GCN5 could mediate SOX9 acetylation at lysine 62 (K62) to enhance SOX9 binding to FGF1 or PDGFalpha promoter and promote FGF1 or PDGFalpha synthesis and GMC proliferation.	Lysine	57-63	lysine acetyltransferase 2A	Rattus norvegicus	18-22
31330113-9	2019	In conclusion, Brd4 expression increases in interface membrane and Brd4 participates in the production of pro-inflammatory cytokines induced by Ti particles via promoting the activation of NF-kappaB signaling and binding to acetylated NF-kappaB p65 (lysine-310) in mouse macrophages.	Lysine	250-256	bromodomain containing 4	Mus musculus	15-19
31330113-9	2019	In conclusion, Brd4 expression increases in interface membrane and Brd4 participates in the production of pro-inflammatory cytokines induced by Ti particles via promoting the activation of NF-kappaB signaling and binding to acetylated NF-kappaB p65 (lysine-310) in mouse macrophages.	Lysine	250-256	bromodomain containing 4	Mus musculus	67-71
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	SAFB like transcription modulator	Homo sapiens	166-169
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	cyclin dependent kinase 1	Homo sapiens	270-279
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	310-314
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	phosphatase and tensin homolog	Homo sapiens	340-344
16396320-3	2005	Analysis of LMP7 gene polymorphism has shown that Lys/Lys - 89.5 %, Lys/Gln - 10.5 %, Gin/Gin - 0 % (in control group 93.8, 6.2, 0 % correspondingly; P &gt; 0.05).	Lysine	54-57	proteasome 20S subunit beta 8	Homo sapiens	12-16
16396320-3	2005	Analysis of LMP7 gene polymorphism has shown that Lys/Lys - 89.5 %, Lys/Gln - 10.5 %, Gin/Gin - 0 % (in control group 93.8, 6.2, 0 % correspondingly; P &gt; 0.05).	Lysine	54-57	proteasome 20S subunit beta 8	Homo sapiens	12-16
16141209-0	2005	Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.	Lysine	23-26	pancreatic and duodenal homeobox 1	Mus musculus	0-5
31628376-6	2019	The N-terminal RING-finger domain of LNX1/2 ubiquitinates a cytoplasmic C-terminal lysine cluster in GlyT2 (K751, K773, K787 and K791), and this process regulates the expression levels and transport activity of GlyT2.	Lysine	83-89	ligand of numb-protein X 1	Homo sapiens	37-43
34289556-12	2021	ChIP-PCR results showed that CRL4B complex directly bound to the promoter regions of the target genes, NME1 and SFRP1, and the enrichment of monoubiquitination of lysine at 119 of histone H2A (H2AK119ub1) in the promoter region of target gene was reduced after CUL4B knockdown.	Lysine	163-169	cullin 4B	Homo sapiens	261-266
16141209-5	2005	We demonstrated here that the 50% fall in insulin transcription following knockdown of Pdx-1 is accompanied by a 60% fall in dimethylated histone H3-Lys-4 at the insulin promoter.	Lysine	149-152	pancreatic and duodenal homeobox 1	Mus musculus	87-92
16210620-7	2005	Mutation of PU.1 lysines 170 and 171 did not affect PU.1 DNA binding, but did lower the ability of PU.1 to activate transcription in association with p300.	Lysine	17-24	E1A binding protein p300	Homo sapiens	150-154
34194459-3	2021	Here we reveal the functions of two Arabidopsis thaliana homologs of human lysine-specific demethylase1-like1, LDL1 and LDL2, in the maintenance of methyl groups at lysine 4 of histone H3 and in plant immunity to Pseudomonas syringae infection.	Lysine	75-81	LSD1-like 1	Arabidopsis thaliana	111-115
34194459-3	2021	Here we reveal the functions of two Arabidopsis thaliana homologs of human lysine-specific demethylase1-like1, LDL1 and LDL2, in the maintenance of methyl groups at lysine 4 of histone H3 and in plant immunity to Pseudomonas syringae infection.	Lysine	165-171	LSD1-like 1	Arabidopsis thaliana	111-115
31311807-6	2019	In an acetylation-dependent manner, BRD4 recognized acetylated lysine 146 (K146) and K187 on Snail to prevent Snail recognition by its E3 ubiquitin ligases FBXL14 and beta-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation.	Lysine	63-69	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	167-177
20641210-19	2004	From the results of investigating a small library of RGD peptides for their binding activity to the alphavbeta3 integrin, a linear hexapeptide, Gly-Arg-Asp-Ser-Pro-Lys (GRDSPK), lacking the RGD sequence was conjugated with Cypate as Cyp-GRD to study in vivo biodistribution of the tracer in tumor-bearing mice (18).	Lysine	164-167	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	223-226
31527837-5	2019	KAT2A selectively acetylates H2A.Z.1 versus H2A.Z.2 in vitro on several well-defined lysines and we unveiled that alanine-14 in H2A.Z.2 is responsible for inhibiting the activity of KAT2A.	Lysine	85-92	H2A.Z variant histone 1	Homo sapiens	29-36
31433161-0	2019	SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration.	Lysine	10-16	RAS like proto-oncogene B	Homo sapiens	58-62
34099649-0	2021	Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.	Lysine	26-32	mixed lineage kinase domain like pseudokinase	Homo sapiens	18-22
34071322-1	2021	Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in CREBBP or EP300 genes encoding CBP/p300 lysine acetyltransferases.	Lysine	134-140	E1A binding protein p300	Homo sapiens	104-109
16081417-1	2005	WNK1 (with no lysine (K) 1) is a protein-serine/threonine kinase with a unique catalytic site organization.	Lysine	14-20	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
34071322-1	2021	Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in CREBBP or EP300 genes encoding CBP/p300 lysine acetyltransferases.	Lysine	134-140	E1A binding protein p300	Homo sapiens	129-133
31433161-2	2019	Recently, it has been shown that K-Ras4a, R-Ras2, and Rac1 are regulated by lysine fatty acylation.	Lysine	76-82	RAS related 2	Homo sapiens	42-48
31433161-6	2019	We show that RalB has C-terminal lysine fatty acylation, with the predominant modification site being Lys200.	Lysine	33-39	RAS like proto-oncogene B	Homo sapiens	13-17
31433161-7	2019	The lysine acylation of RalB is regulated by SIRT2, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacylases.	Lysine	4-10	RAS like proto-oncogene B	Homo sapiens	24-28
31433161-7	2019	The lysine acylation of RalB is regulated by SIRT2, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacylases.	Lysine	4-10	sirtuin 2	Homo sapiens	45-50
31433161-8	2019	Lysine fatty acylated RalB exhibited enhanced plasma membrane localization and recruited its known effectors Sec5 and Exo84, members of the exocyst complex, to the plasma membrane.	Lysine	0-6	RAS like proto-oncogene B	Homo sapiens	22-26
31317175-8	2019	Previous studies reported that collagen glycosylation of Lys residues mediated by lysyl hydroxylase3 is glucosyl-galactosyl-hydroxylation, presuming that this collagen-like glycosylation detected at Lys203 of recombinant CCN1 in this study might be glucosyl-galactosyl-hydroxylation.	Lysine	57-60	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	82-100
34094823-8	2021	In recent years, there have been considerable advances in our understanding of NCC control mechanisms, particularly via the pathway containing the with-no-lysine (K) (WNK) and its downstream target kinases, SPS/Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress responsive 1 (OSR1), which has led to the discovery of novel inhibitory molecules.	Lysine	155-161	solute carrier family 12 member 3	Homo sapiens	79-82
31317175-8	2019	Previous studies reported that collagen glycosylation of Lys residues mediated by lysyl hydroxylase3 is glucosyl-galactosyl-hydroxylation, presuming that this collagen-like glycosylation detected at Lys203 of recombinant CCN1 in this study might be glucosyl-galactosyl-hydroxylation.	Lysine	57-60	cellular communication network factor 1	Homo sapiens	221-225
15849232-3	2005	Using l-lysine, the preferred amino acid transported by CAT-1, we competitively inhibited extracellular l-arginine transport into endothelial cells during conditions of NaCl hyperosmolarity, low oxygen, and flow increase.	Lysine	6-14	solute carrier family 7 member 1	Rattus norvegicus	56-61
31527584-2	2019	Since EED is a Polycomb-Group protein and a core component of the polycomb repressive complex 2 (PRC2), we tested the involvement of PICOT in the regulation of PRC2-mediated H3 lysine 27 trimethylation (H3K27me3), transcription and translation of selected PRC2 target genes.	Lysine	177-183	glutaredoxin 3	Homo sapiens	133-138
34973011-2	2021	In previous work, we reported that the circadian transcription factor CLOCK and its heterodimer partner BMAL1 suppress the transcriptional activity of the glucocorticoid receptor (GR) by acetylating a lysine cluster located in its hinge region between the DNA- and ligand-binding domains.	Lysine	201-207	clock circadian regulator	Homo sapiens	70-75
16550483-6	2005	Sperm exposed to fluorescein-conjugated poly-L-lysine or Alexa488-histone showed a very uniform fluorescent labeling pattern over the entire sperm surface, almost identical to that observed with anti-DEFB126 Ig label.	Lysine	40-53	beta-defensin 126	Macaca fascicularis	200-207
34189273-3	2021	We identified lysine-143 in the equine arteritis virus (EAV) protein, nsp7, as a primary site of in vitro GMP attachment via a phosphoramide bond.	Lysine	14-20	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	70-74
34189273-4	2021	In SARS-CoV-2 replicase proteins, we demonstrate nsp12-mediated nucleotidylation of nsp7 lysine-2.	Lysine	89-95	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	84-88
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Lysine	192-200	antizyme inhibitor 1 L homeolog	Xenopus laevis	37-44
31509528-9	2019	Collectively, our results indicate that in Xenopus there is only one antizyme inhibitor (xlAZIN1) and two decarboxylases, xlODC1 and xlLDC, with clear preferences for L-ornithine and L-lysine, respectively.	Lysine	183-191	antizyme inhibitor 1 L homeolog	Xenopus laevis	89-96
31509528-9	2019	Collectively, our results indicate that in Xenopus there is only one antizyme inhibitor (xlAZIN1) and two decarboxylases, xlODC1 and xlLDC, with clear preferences for L-ornithine and L-lysine, respectively.	Lysine	183-191	ornithine decarboxylase 1 L homeolog	Xenopus laevis	122-128
31375263-3	2019	This autophagic degradation initiates when the transmembrane E3 ligase TRIM13 (also known as RFP2) is ubiquitinated via the lysine 63 (K63) linkage.	Lysine	124-130	tripartite motif containing 13	Homo sapiens	71-77
16191191-5	2005	In contrast to Cdk2-cyclin A, which has a well-defined consensus target site ((S/T)PX(K/R)) that strongly favors substrates containing a lysine at the +3 position of substrates, Cdk2-Speedy/Ringo A2 displayed a broad substrate specificity at this position.	Lysine	137-143	cyclin dependent kinase 2	Homo sapiens	15-19
31375263-3	2019	This autophagic degradation initiates when the transmembrane E3 ligase TRIM13 (also known as RFP2) is ubiquitinated via the lysine 63 (K63) linkage.	Lysine	124-130	tripartite motif containing 13	Homo sapiens	93-97
30953095-1	2019	alpha-Tubulin acetyltransferase 1 (ATAT1) catalyzes acetylation of alpha-tubulin at lysine 40 in various organisms ranging from Tetrahymena to humans.	Lysine	84-90	alpha tubulin acetyltransferase 1	Homo sapiens	0-33
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	transforming growth factor alpha	Homo sapiens	248-256
34227356-5	2021	Protein ubiquitination occurs through the formation of a covalent bond between the carboxyl terminus of ubiquitin and the epsilon-amino group of a lysine residue in the substrate.	Lysine	147-153	ubiquitin	Saccharomyces cerevisiae S288C	104-113
34227356-7	2021	There are eight sites, namely seven lysine residues (K6, K11, K27, K29, K33, K48, and K63) and one N-terminal methionine (M1), in one ubiquitin molecule that can be used to form a ubiquitin dimer.	Lysine	36-42	ubiquitin	Saccharomyces cerevisiae S288C	134-143
30953095-1	2019	alpha-Tubulin acetyltransferase 1 (ATAT1) catalyzes acetylation of alpha-tubulin at lysine 40 in various organisms ranging from Tetrahymena to humans.	Lysine	84-90	alpha tubulin acetyltransferase 1	Homo sapiens	35-40
16227196-11	2005	Epsilon aminocaproic acid and tranexamic acid are lysine analogs that reduce bleeding by inhibiting the conversion of plasminogen to plasmin, a serine protease responsible for breaking down fibrinogen to fibrin.	Lysine	50-56	plasminogen	Homo sapiens	118-125
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	lysine methyltransferase 2A	Homo sapiens	51-54
31485071-1	2019	Methyltransferases of the mixed-lineage leukaemia (MLL) family-which include MLL1, MLL2, MLL3, MLL4, SET1A and SET1B-implement methylation of histone H3 on lysine 4 (H3K4), and have critical and distinct roles in the regulation of transcription in haematopoiesis, adipogenesis and development1-6.	Lysine	156-162	lysine methyltransferase 2A	Homo sapiens	77-81
31485071-5	2019	H3K4 methylation is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120ub1), a prevalent histone H2B mark that disrupts chromatin compaction and favours open chromatin structures, but the underlying mechanism remains unknown10-12.	Lysine	72-78	H2B clustered histone 21	Homo sapiens	65-68
34227356-7	2021	There are eight sites, namely seven lysine residues (K6, K11, K27, K29, K33, K48, and K63) and one N-terminal methionine (M1), in one ubiquitin molecule that can be used to form a ubiquitin dimer.	Lysine	36-42	ubiquitin	Saccharomyces cerevisiae S288C	180-189
35569250-1	2022	Adenovirus E1A-associated 300-kD protein (p300) bromodomain, which regulates gene expression by recognizing acetylated lysine (KAc) of histone, is a promising target for the treatment of cancer.	Lysine	119-125	E1A binding protein p300	Homo sapiens	42-46
31375747-0	2019	HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells.	Lysine	26-32	histone deacetylase 7	Homo sapiens	0-5
31375747-5	2019	We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start sites (TSS) and super-enhancers (SEs) prominently in stem-like BrCa cells.	Lysine	136-142	histone deacetylase 7	Homo sapiens	65-70
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	50-56	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	90-93
16148121-6	2005	Expression of the activating Ly-49D and inhibitory Ly-49G2 receptors on recipient NK cells was significantly decreased in these beta(2)m(-/-)--&gt;B6 chimeras, and the proportion of donor NK cells expressing Ly-49D was also significantly decreased.	Lysine	29-31	beta-2 microglobulin	Mus musculus	128-136
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	50-56	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	198-201
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	76-82	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	90-93
16096646-0	2005	Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.	Lysine	54-60	high mobility group nucleosome binding domain 1	Homo sapiens	20-25
31398828-5	2019	The protease side-activities mainly acted on the hydrophobic C-terminus of beta-CN at Ala, Pro, Ile, Phe, Leu, Lys, Gln, and Tyr positions, resulting in the formation of peptides, some of which were N-terminal glycated or potentially bitter.	Lysine	111-114	apoptotic chromatin condensation inducer 1	Homo sapiens	75-82
35613279-6	2022	SIRT5 was engineered to resist acylation-driven inhibition via lysine to arginine mutagenesis.	Lysine	63-69	sirtuin 5	Mus musculus	0-5
35614060-0	2022	Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming.	Lysine	46-52	CCCTC-binding factor	Mus musculus	105-109
31213526-0	2019	Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.	Lysine	33-39	adenine nucleotide translocase lysine methyltransferase	Homo sapiens	6-13
15931461-2	2005	In this study, we extended the characterization of p91 and p102 and our results were as follows; (i) Lysine at amino acid position 450 in IE1p68 and at amino acid position 175 or 180 in IE2p80, to which SUMO-1 has been shown to be covalently linked, are required for production of p91 and p102, respectively.	Lysine	101-107	minichromosome maintenance complex component 3	Homo sapiens	59-63
31213526-0	2019	Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.	Lysine	33-39	solute carrier family 25 member 6	Homo sapiens	80-110
31213526-5	2019	Immunoblotting analysis using methyllysine-specific antibodies revealed that FAM173A knock-out (KO) abrogates lysine methylation of a single mitochondrial protein in human cells.	Lysine	36-42	adenine nucleotide translocase lysine methyltransferase	Homo sapiens	77-84
31213526-7	2019	We found that methylation occurs at Lys-52 of ANT, which was previously reported to be trimethylated.	Lysine	36-39	solute carrier family 25 member 6	Homo sapiens	46-49
31213526-8	2019	Complementation of KO cells with WT or enzyme-dead FAM173A indicated that the enzymatic activity of FAM173A is required for ANT methylation at Lys-52 to occur.	Lysine	143-146	adenine nucleotide translocase lysine methyltransferase	Homo sapiens	51-58
31213526-8	2019	Complementation of KO cells with WT or enzyme-dead FAM173A indicated that the enzymatic activity of FAM173A is required for ANT methylation at Lys-52 to occur.	Lysine	143-146	adenine nucleotide translocase lysine methyltransferase	Homo sapiens	100-107
31213526-8	2019	Complementation of KO cells with WT or enzyme-dead FAM173A indicated that the enzymatic activity of FAM173A is required for ANT methylation at Lys-52 to occur.	Lysine	143-146	solute carrier family 25 member 6	Homo sapiens	124-127
35439434-3	2022	Here, we implicate methylation of histone H3 at lysine 4 by SETD1A-BOD1L in the recruitment of RIF1 to DSBs.	Lysine	48-54	replication timing regulatory factor 1	Homo sapiens	95-99
16135803-0	2005	p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28.	Lysine	111-117	tumor protein p73	Homo sapiens	0-3
35579947-5	2022	Mechanistically, hnRNPA1 bound with SUMO2 at the lysine 113 residue via KRASG12D-induced hyperactivation of SUMOylation, which enabled its interaction with TSG101 to enhance hnRNPA1 packaging and transmission via EVs.	Lysine	49-55	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	17-24
31213526-11	2019	In summary, we demonstrate that FAM173A is the long-sought KMT responsible for ANT methylation at Lys-52, and point out the functional significance of Lys-52 methylation in ANT.	Lysine	98-101	adenine nucleotide translocase lysine methyltransferase	Rattus norvegicus	32-39
31213526-11	2019	In summary, we demonstrate that FAM173A is the long-sought KMT responsible for ANT methylation at Lys-52, and point out the functional significance of Lys-52 methylation in ANT.	Lysine	98-101	solute carrier family 25 member 6	Homo sapiens	79-82
31213526-11	2019	In summary, we demonstrate that FAM173A is the long-sought KMT responsible for ANT methylation at Lys-52, and point out the functional significance of Lys-52 methylation in ANT.	Lysine	151-154	adenine nucleotide translocase lysine methyltransferase	Rattus norvegicus	32-39
31213526-11	2019	In summary, we demonstrate that FAM173A is the long-sought KMT responsible for ANT methylation at Lys-52, and point out the functional significance of Lys-52 methylation in ANT.	Lysine	151-154	solute carrier family 25 member 6	Homo sapiens	173-176
35579947-5	2022	Mechanistically, hnRNPA1 bound with SUMO2 at the lysine 113 residue via KRASG12D-induced hyperactivation of SUMOylation, which enabled its interaction with TSG101 to enhance hnRNPA1 packaging and transmission via EVs.	Lysine	49-55	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	174-181
16135803-6	2005	Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF.	Lysine	64-70	tumor protein p73	Homo sapiens	15-18
16135803-6	2005	Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF.	Lysine	64-70	lysine acetyltransferase 2B	Homo sapiens	77-81
31012223-6	2019	Consistently, the ubiquitin (UB) mutant at lysine 29 (K29R) or the K29-deubiquitinating enzyme TRAF-binding protein domain (TRABID) attenuated the effect of ERalpha on Cav1.2.	Lysine	43-49	estrogen receptor 1 (alpha)	Mus musculus	157-164
15958389-3	2005	Here we demonstrate that human HIPK2 is small ubiquitin-related modifier-1 (SUMO-1)-modified in vitro and in vivo at lysine residue 25, a SUMO consensus modification motif conserved in human and mouse HIPK family proteins.	Lysine	117-123	small ubiquitin like modifier 1	Homo sapiens	40-74
31128196-3	2019	The ELP is precisely tailored to a silica-mineralizing peptide by programming it with lysine residues.	Lysine	86-92	nuclear receptor subfamily 5 group A member 1	Homo sapiens	4-7
35606079-4	2022	The remarkable homology between apo(a) and the fibrinolytic proenzyme plasminogen strongly suggests an antifibrinolytic role: apo(a) contains a strong lysine binding site and can block the sites on fibrin and cellular receptors required for plasminogen activation, but itself lacks proteolytic activity.	Lysine	151-157	lipoprotein(a)	Homo sapiens	32-38
35606079-4	2022	The remarkable homology between apo(a) and the fibrinolytic proenzyme plasminogen strongly suggests an antifibrinolytic role: apo(a) contains a strong lysine binding site and can block the sites on fibrin and cellular receptors required for plasminogen activation, but itself lacks proteolytic activity.	Lysine	151-157	lipoprotein(a)	Homo sapiens	126-132
15958389-3	2005	Here we demonstrate that human HIPK2 is small ubiquitin-related modifier-1 (SUMO-1)-modified in vitro and in vivo at lysine residue 25, a SUMO consensus modification motif conserved in human and mouse HIPK family proteins.	Lysine	117-123	small ubiquitin like modifier 1	Homo sapiens	76-82
35606081-4	2022	A substantial fraction of the OxPL on Lp(a) are covalently bound to the KIV10 domain of apo(a), and the strong lysine binding site (LBS) in this kringle is required for OxPL addition.	Lysine	111-117	lipoprotein(a)	Homo sapiens	38-43
35606081-4	2022	A substantial fraction of the OxPL on Lp(a) are covalently bound to the KIV10 domain of apo(a), and the strong lysine binding site (LBS) in this kringle is required for OxPL addition.	Lysine	111-117	lipoprotein(a)	Homo sapiens	88-94
16029420-4	2005	In vitro assays further show that sumoylation occurs at two lysine residues, K182 and K316, and depends on SUMO E1 activating enzyme (SAE I/SAE II) and E2 conjugating enzyme (Ubc9).	Lysine	60-66	ubiquitin conjugating enzyme E2 I	Homo sapiens	175-179
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	lymphoid enhancer binding factor 1	Homo sapiens	179-213
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	lymphoid enhancer binding factor 1	Homo sapiens	215-219
31403616-7	2019	We illustrate these reactions using minimal components of the mouse Polycomb Repressive Complex 1 (PRC1), BMI1, and RING1B, an E3 ubiquitin ligase that monoubiquitinates histone H2A on lysine 119.	Lysine	185-191	ring finger protein 2	Mus musculus	116-122
31266503-2	2019	Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues.	Lysine	183-189	bromodomain testis associated	Homo sapiens	68-72
31267712-1	2019	Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly understood.	Lysine	37-43	H2B clustered histone 21	Homo sapiens	30-33
15931174-3	2005	Upon DNA damage, PCNA is modified at the conserved lysine residue 164 by either mono-ubiquitin or a lysine-63-linked multi-ubiquitin chain, which induce error-prone or error-free replication bypasses of the lesions.	Lysine	51-57	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	17-21
35244191-5	2022	Notably, it was identified that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was decreased by silencing of USP22 and USP22 was found to remove lysine 48-linked poly-ubiquitination chains from TRAF6 to stabilize TRAF6 expression and these effects were clearly aggravated following PA infection.	Lysine	175-181	ubiquitin specific peptidase 22	Mus musculus	139-144
35244191-5	2022	Notably, it was identified that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was decreased by silencing of USP22 and USP22 was found to remove lysine 48-linked poly-ubiquitination chains from TRAF6 to stabilize TRAF6 expression and these effects were clearly aggravated following PA infection.	Lysine	175-181	ubiquitin specific peptidase 22	Mus musculus	149-154
31141788-6	2019	Moreover, the histone 3 lysine 14 acetylation (H3K14ac) level in the Igf1 promoter region was reduced.	Lysine	24-30	insulin-like growth factor 1	Rattus norvegicus	69-73
15931174-3	2005	Upon DNA damage, PCNA is modified at the conserved lysine residue 164 by either mono-ubiquitin or a lysine-63-linked multi-ubiquitin chain, which induce error-prone or error-free replication bypasses of the lesions.	Lysine	100-106	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	17-21
15908697-7	2005	Molecular modeling of the Rad51-G103E mutant protein shows that the negatively charged glutamate residue lies on the surface of the N-terminal domain facing a positively charged patch composed of Arg-260, His-302, and Lys-305 on the ATPase core domain.	Lysine	218-221	recombinase RAD51	Saccharomyces cerevisiae S288C	26-31
31067149-5	2019	Lysine residues within the transmembrane domain of Snc1 are necessary for presentation of a Snx4-Atg20-dependent sorting signal located within its juxtamembrane region.	Lysine	0-6	SNAP receptor SNC1	Saccharomyces cerevisiae S288C	51-55
31067149-6	2019	Mutations of the transmembrane lysine residues ablate retrograde sorting and subject Snc1 to quality control via sorting into the degradative multivesicular endosome pathway.	Lysine	31-37	SNAP receptor SNC1	Saccharomyces cerevisiae S288C	85-89
31067149-7	2019	Degradative sorting requires lysine residues in the juxtamembrane region of Snc1 and is mediated by the Rsp5 ubiquitin ligase and its transmembrane adapters, Ear1 and Ssh4, which localize to endosome and vacuole membranes.	Lysine	29-35	SNAP receptor SNC1	Saccharomyces cerevisiae S288C	76-80
35449295-1	2022	The lysine-63 deubiquitinase cylindromatosis (CYLD) is long recognized as a tumor suppressor in immunity and inflammation, and its loss-of-function mutations lead to familial cylindromatosis.	Lysine	4-10	CYLD lysine 63 deubiquitinase	Mus musculus	46-50
35474067-5	2022	We now report that Cullin 3-KLHL20, a trans-Golgi network (TGN)-localized E3 ubiquitin ligase, polyubiquitinates SERINC5 at lysine 130 via K33/K48-linked ubiquitination.	Lysine	124-130	serine incorporator 5	Homo sapiens	113-120
16024656-4	2005	RNAi against hSki8 or hCtr9 reduces the cellular levels of other hPAF subunits and of mono- and trimethylated H3-Lys 4 and dimethylated H3-Lys 79.	Lysine	113-116	WD repeat domain 61	Homo sapiens	13-18
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	142-150	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	142-150	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	152-155	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	152-155	glycine amidinotransferase	Rattus norvegicus	39-43
30939013-6	2019	PEG chains coordinating in looplike conformations were found near lysine residues.	Lysine	66-72	progestagen associated endometrial protein	Homo sapiens	0-3
31247018-7	2019	In the process, among the interacting residues of PI3Kgamma, the Lys-890 and the Met-953 were recognized as the key residues involved in XL765 binding.	Lysine	65-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	50-59
16024656-4	2005	RNAi against hSki8 or hCtr9 reduces the cellular levels of other hPAF subunits and of mono- and trimethylated H3-Lys 4 and dimethylated H3-Lys 79.	Lysine	139-142	WD repeat domain 61	Homo sapiens	13-18
16029044-0	2005	Ligand-directed labeling of a single lysine residue in hGST A1-1 mutants.	Lysine	37-43	glutathione S-transferase alpha 1	Homo sapiens	55-64
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	164-167	glycine amidinotransferase	Rattus norvegicus	0-37
15870073-7	2005	Mutation of either Lys(691) or Lys(692) prevented GRK2-mediated attenuation of mGluR1b signaling, whereas the mutation of only Lys(692) prevented GRK2-mediated inhibition of mGluR1a signaling.	Lysine	19-22	glutamate metabotropic receptor 1	Homo sapiens	79-85
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	164-167	glycine amidinotransferase	Rattus norvegicus	39-43
31242411-3	2019	We present evidence that loss of FACT has a dramatic impact on Pol II elongation-coupled processes including histone H3 lysine 4 (H3K4) and H3K36 methylation, consistent with a role for FACT in coordinating histone modification and chromatin architecture during Pol II transcription.	Lysine	120-126	RNA polymerase II 215kD subunit	Drosophila melanogaster	63-69
31242411-3	2019	We present evidence that loss of FACT has a dramatic impact on Pol II elongation-coupled processes including histone H3 lysine 4 (H3K4) and H3K36 methylation, consistent with a role for FACT in coordinating histone modification and chromatin architecture during Pol II transcription.	Lysine	120-126	RNA polymerase II 215kD subunit	Drosophila melanogaster	262-268
15972680-9	2005	The level of p65 binding correlates with a binary shift in nucleosome remodeling between histone H3 phosphorylation at serine 10 and methylation of histone H3 at lysine 9.	Lysine	162-168	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-16
31048377-3	2019	Special interest has been devoted to a series of mutants exacerbating the effects of the E46K mutation (associated with autosomal dominant PD) through homologous Glu-to-Lys substitutions in alphaSyn"s N-terminal region (i.e. E35K and E61K).	Lysine	169-172	synuclein, alpha	Mus musculus	190-198
35563734-0	2022	Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis.	Lysine	63-69	plastin 1	Homo sapiens	0-4
15994808-3	2005	A low percentage of the HIV-1 p6 protein has previously been shown to be ubiquitinated, and published mutagenesis data suggested that Gag ubiquitination is largely lost upon mutation of the two lysine residues in p6.	Lysine	194-200	Pr55(Gag)	Human immunodeficiency virus 1	134-137
35380918-4	2022	In this study, we showed that TRAF6 mediates oxidative stress-induced ATG9A ubiquitination at two C-terminal lysine residues (K581 and K838).	Lysine	109-115	autophagy related 9A	Homo sapiens	70-75
30082770-7	2019	Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPARgamma.	Lysine	0-6	selenoprotein S	Homo sapiens	41-45
15994808-4	2005	In this study, we show that Gag proteins lacking the p6 domain or the two lysine residues within p6 are ubiquitinated at levels comparable to those of the wild-type Gag protein.	Lysine	74-80	Pr55(Gag)	Human immunodeficiency virus 1	28-31
35233835-6	2022	Furthermore, NOR was shown to elevate the level of acetyl-CoA derived from FAO and acetylation of lysine 27 on histone 3 (H3K27) at the Foxp3 promoter and CNS2 regions.	Lysine	98-104	forkhead box P3	Rattus norvegicus	136-141
15994808-9	2005	In summary, these results indicate that HIV-1 Gag can be monoubiquitinated in all domains and that ubiquitination of lysine residues outside p6 may thus contribute to viral release and/or infectivity.	Lysine	117-123	Pr55(Gag)	Human immunodeficiency virus 1	46-49
30791110-7	2019	By disrupting an evolutionarily conserved Cullin4A-damage-specific DNA binding protein 1-RING type of E3 ligase, CRL4WDR70 , through its H-box, we show that HBx inhibits H2B monoubiquitylation at lysine 120 at double-strand breaks, thus reducing the efficiency of long-range resection.	Lysine	196-202	X protein	Hepatitis B virus	157-160
15933069-2	2005	We present here the crystal structure of a ternary complex of the enzyme Pr-Set7 (also known as Set8) that methylates Lys 20 of histone H4 (H4-K20).	Lysine	118-121	lysine methyltransferase 5A	Homo sapiens	96-100
30791110-7	2019	By disrupting an evolutionarily conserved Cullin4A-damage-specific DNA binding protein 1-RING type of E3 ligase, CRL4WDR70 , through its H-box, we show that HBx inhibits H2B monoubiquitylation at lysine 120 at double-strand breaks, thus reducing the efficiency of long-range resection.	Lysine	196-202	H2B clustered histone 21	Homo sapiens	170-173
15933070-2	2005	Herein we report the crystal structure of human SET8 (hSET8) bound to a histone H4 peptide bearing Lys-20 and the product cofactor S-adenosylhomocysteine.	Lysine	99-102	lysine methyltransferase 5A	Homo sapiens	48-52
35066023-2	2022	The combined action of chemical chaperones trehalose, betaine and lysine on stability, aggregation and oligomeric state of muscle glycogen phosphorylase b (Phb) has been studied.	Lysine	66-72	prohibitin 1	Homo sapiens	139-154
35066023-2	2022	The combined action of chemical chaperones trehalose, betaine and lysine on stability, aggregation and oligomeric state of muscle glycogen phosphorylase b (Phb) has been studied.	Lysine	66-72	prohibitin 1	Homo sapiens	156-159
15933070-2	2005	Herein we report the crystal structure of human SET8 (hSET8) bound to a histone H4 peptide bearing Lys-20 and the product cofactor S-adenosylhomocysteine.	Lysine	99-102	lysine methyltransferase 5A	Homo sapiens	54-59
35066023-3	2022	Dynamic light scattering data indicate that the affinity of trehalose to Phb increased in the presence of betaine or lysine at both stages (stage of nucleation and aggregate growth) of enzyme aggregation at 48  C, in contrast, the affinity of betaine to the enzyme in the presence of lysine remained practically unchanged.	Lysine	117-123	prohibitin 1	Homo sapiens	73-76
30302725-1	2019	The disruptor of telomeric silencing 1-like (DOT1L) mediates methylation of histone H3 at position lysine 79 (H3K79).	Lysine	99-105	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	4-43
30302725-1	2019	The disruptor of telomeric silencing 1-like (DOT1L) mediates methylation of histone H3 at position lysine 79 (H3K79).	Lysine	99-105	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	45-50
35066023-3	2022	Dynamic light scattering data indicate that the affinity of trehalose to Phb increased in the presence of betaine or lysine at both stages (stage of nucleation and aggregate growth) of enzyme aggregation at 48  C, in contrast, the affinity of betaine to the enzyme in the presence of lysine remained practically unchanged.	Lysine	284-290	prohibitin 1	Homo sapiens	73-76
35066023-6	2022	The main protective effect of the mixtures of osmolytes and lysine is associated with their influence on the dissociation/denaturation stage, which is the rate-limiting one of Phb aggregation.	Lysine	60-66	prohibitin 1	Homo sapiens	176-179
15933070-4	2005	Residues preceding Lys-20 in H4 engage in an extensive array of salt bridge, hydrogen bond, and van der Waals interactions with hSET8, while the C-terminal residues bind through predominantly hydrophobic interactions.	Lysine	19-22	lysine methyltransferase 5A	Homo sapiens	128-133
15933070-6	2005	Finally, analysis of the product specificity indicates that hSET8 is a monomethylase, consistent with its role in the maintenance of Lys-20 monomethylation during cell division.	Lysine	133-136	lysine methyltransferase 5A	Homo sapiens	60-65
30894683-5	2019	We identified UBR5 as a major ubiquitin E3 ligase that induces SOX2 degradation through ubiquitinating SOX2 at lysine 115.	Lysine	111-117	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	14-18
15973048-3	2005	Here we describe mutant Put4 permeases, in which up to nine lysine residues in the cytoplasmic N-terminal domain have been replaced by arginine.	Lysine	60-66	proline permease PUT4	Saccharomyces cerevisiae S288C	24-28
30951287-2	2019	Disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, plays an important role in the progressions of mixed-lineage leukemia (MLL)-rearranged leukemias and has been validated as a potential therapeutic target.	Lysine	62-68	lysine methyltransferase 2A	Homo sapiens	170-173
15973048-4	2005	The steady-state protein level of the mutant permease Put4-20p (Lys9, Lys34, Lys35, Lys60, Lys68, Lys71, Lys93, Lys105, Lys107 --&gt; Arg) was largely higher compared to that of the wild-type Put4p, indicating that the N-terminal lysines can undergo ubiquitination and the subsequent degradation steps.	Lysine	230-237	proline permease PUT4	Saccharomyces cerevisiae S288C	54-58
30951287-6	2019	Treatment of MLL-rearranged leukemia cells with MA gives a dose-dependent reduction in cellular levels of histone lysine 79 mono- and dimethylation without affecting the methylation of other histone sites.	Lysine	114-120	lysine methyltransferase 2A	Homo sapiens	13-16
35157847-0	2022	Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.	Lysine	83-89	sirtuin 5	Mus musculus	68-73
15893521-9	2005	Taking these data together, we suggest that SST-induced hSSTR1 up-regulation is critically dependent upon a specific Lys-Ser-Arg sequence in the C-tail of the receptor, with Ser360 being essential.	Lysine	117-120	somatostatin receptor 1	Homo sapiens	56-62
31069272-4	2019	Here we show that the Arg-Arg-Lys (RRK) stretch of the C-terminal ELYS region plays an essential role in the nucleosome binding.	Lysine	30-33	AT-hook containing transcription factor 1	Homo sapiens	66-70
15907489-0	2005	Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.	Lysine	10-16	SMAD family member 3	Homo sapiens	47-52
30886050-6	2019	We further determined that FOXP3 undergoes K63-linked ubiquitination at lysine 262 mediated by the E3 ligase TRAF6.	Lysine	72-78	forkhead box P3	Mus musculus	27-32
35347798-5	2022	Epigenetic modification analysis revealed that Hcy significantly increased levels of DNA methylation and H3 lysine 9 dimethylation (H3K9me2) on ERO1alpha promoter, which attributed to up-regulated DNA methyltransferase 1 (DNMT1) and G9a respectively.	Lysine	108-114	endoplasmic reticulum oxidoreductase 1 alpha	Mus musculus	144-153
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Lysine	181-187	mutS homolog 6	Homo sapiens	90-94
15907489-4	2005	In this study, we examined the roles for four lysine residues (Lys-333, Lys-341, Lys-378, and Lys-409) in the Smad3 MH2 domain.	Lysine	46-52	SMAD family member 3	Homo sapiens	110-115
35392432-12	2022	Analysis on molecular mechanisms revealed that KAT5 bonded to the promoter region of PD-L1 and upregulated its expression via enhancing histone H3 lysine 27 acetylation (H3K27ac), whereas ASP downregulated KAT5 expression and blocked this phenomenon.	Lysine	147-153	K(lysine) acetyltransferase 5	Mus musculus	47-51
15907489-9	2005	Thus, the lysine residues of Smad3 MH2 domain play important roles in the transcriptional regulation of TGF-beta signals through TbetaR-I.	Lysine	10-16	SMAD family member 3	Homo sapiens	29-34
15831457-9	2005	These results suggest that sumoylation of Lys(35) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy-dependent sumoylation and transcriptional activation of Tcf-4.	Lysine	42-45	transcription factor 4	Homo sapiens	195-200
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	66-72	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	232-237
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	66-72	angiotensin converting enzyme 2	Homo sapiens	246-250
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	153-159	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	232-237
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	153-159	angiotensin converting enzyme 2	Homo sapiens	246-250
30786218-5	2019	A hydrophobic, lysine-rich domain in maspin consists of 27 aa, is located at position 268-294, and is responsible for the interaction of this protein with cardiolipin.	Lysine	15-21	serpin family B member 5	Homo sapiens	37-43
15837933-8	2005	Importantly, one surface-exposed lysine is required for activation of HDAC3, but not for interaction.	Lysine	33-39	histone deacetylase 3	Homo sapiens	70-75
30849386-7	2019	Mass spectrometry analyses revealed a greater number of acetylated lysine residues in alpha-crystallin isolated from the SIRT3 and SIRT5 KO lenses than from WT lenses.	Lysine	67-73	sirtuin 3	Mus musculus	121-126
35592609-3	2022	Among these, RNF168-mediated ubiquitination of lysines 13 or 15 at the N-terminal tail of histone H2A (H2AK13/15Ub) is essential for the recruitment of effectors of both the non-homologous end joining (NHEJ) and the homologous recombination (HR) repair pathways.	Lysine	47-54	ring finger protein 168	Homo sapiens	13-19
31397596-3	2019	This amino acid substitution involves the alpha1beta2 contact and occurs at the same position as Hb Austin [beta40(C6)Arg Ser; HBB: c.[123G&gt;C or 123G&gt;T] (p.Arg41Ser)] and Hb Athens-GA [beta40(C6)Arg Lys; HBB: c.122G&gt;A (p.Arg41Lys)], both of which show increased oxygen affinity.	Lysine	205-208	hemoglobin subunit beta	Homo sapiens	127-130
15837933-9	2005	This lysine may play a uniquely important role in the mechanism of activating HDAC3.	Lysine	5-11	histone deacetylase 3	Homo sapiens	78-83
31011153-7	2019	ERF109 upregulates ANTHRANILATE SYNTHASE alpha1 (ASA1)-a tryptophan biosynthesis gene in the auxin production pathway8-10-dependent on the pre-deposition of SET DOMAIN GROUP8 (SDG8)-mediated histone H3 lysine 36 trimethylation (H3K36me3)11 on the ASA1 locus.	Lysine	202-208	histone-lysine N-methyltransferase	Arabidopsis thaliana	157-174
31011153-7	2019	ERF109 upregulates ANTHRANILATE SYNTHASE alpha1 (ASA1)-a tryptophan biosynthesis gene in the auxin production pathway8-10-dependent on the pre-deposition of SET DOMAIN GROUP8 (SDG8)-mediated histone H3 lysine 36 trimethylation (H3K36me3)11 on the ASA1 locus.	Lysine	202-208	histone-lysine N-methyltransferase	Arabidopsis thaliana	176-180
15725630-2	2005	In S. cerevisiae, a second complex, UBC13/MMS2/RAD5, can extend this single ubiquitin with a non-canonical lysine 63-linked chain.	Lysine	107-113	E2 ubiquitin-conjugating protein UBC13	Saccharomyces cerevisiae S288C	36-41
30996128-8	2019	A function of the 53BP1 protein is also linked to a specific histone signature, including phosphorylation of histone H2AX (gammaH2AX) or methylation of histone H4 at the lysine 20 position (H4K20me); therefore, we also discuss an epigenetic landscape of 53BP1-positive DNA lesions.	Lysine	170-176	tumor protein p53 binding protein 1	Homo sapiens	18-23
35246238-2	2022	SETD8 is so far the only known lysyl methyltransferase in mammalian cells to produce mono-methylation of histone H4 at lysine 20 (H4K20me1), a prerequisite for di- and tri-methylation.	Lysine	119-125	lysine methyltransferase 5A	Homo sapiens	0-5
35246238-8	2022	In this review, we discuss the progress made to date in roles for the lysine mono-methyltransferase SETD8 in DNA damage repair and its therapeutic relevance, in particular illuminating its involvement in establishment of DSB repair pathway choice, which is crucial for the timely elimination of DSBs.	Lysine	70-76	lysine methyltransferase 5A	Homo sapiens	100-105
15725630-2	2005	In S. cerevisiae, a second complex, UBC13/MMS2/RAD5, can extend this single ubiquitin with a non-canonical lysine 63-linked chain.	Lysine	107-113	E2 ubiquitin-conjugating protein MMS2	Saccharomyces cerevisiae S288C	42-46
15725630-2	2005	In S. cerevisiae, a second complex, UBC13/MMS2/RAD5, can extend this single ubiquitin with a non-canonical lysine 63-linked chain.	Lysine	107-113	DNA helicase RAD5	Saccharomyces cerevisiae S288C	47-51
30990809-6	2019	RESULTS: We identified KMT2D, SETD1A and SETD2, included in the lysine methyltransferase activity function, as linked with poor prognosis in invasive breast cancer.	Lysine	64-70	lysine methyltransferase 2D	Homo sapiens	23-28
16705796-4	2005	ARD-1, the acetyltransferase, acetylates HIF-1a at lysine 532, which enhances the interaction of HIF-1a with pVHL.	Lysine	51-57	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	0-5
35308356-11	2022	The purified Odc1 protein decarboxylated lysine into cadaverine, while the recombinant Odc2 protein preferentially produced putrescine from ornithine but also exhibited low lysine decarboxylating activity.	Lysine	41-47	ornithine decarboxylase 1	Homo sapiens	13-17
35230082-0	2022	Probing the Role of Aurora Kinase A Threonylation with Site-Specific Lysine Threonylation.	Lysine	69-75	aurora kinase A	Homo sapiens	20-35
16705796-4	2005	ARD-1, the acetyltransferase, acetylates HIF-1a at lysine 532, which enhances the interaction of HIF-1a with pVHL.	Lysine	51-57	von Hippel-Lindau tumor suppressor	Homo sapiens	109-113
35230082-4	2022	Here we report a chemical biology approach for site-specific incorporation of Nepsilon-threonyllysine into proteins with high efficiency and investigate the biological effect of lysine threonylation on Aurora kinase A.	Lysine	178-184	aurora kinase A	Homo sapiens	202-217
30992691-12	2019	Elevated RNF8 expression promotes the interaction between RARA and RNF8 and induces RARA Lys-48 linkage ubiquitylation and degradation, resulting in attenuated transcriptional activation of RARA.	Lysine	89-92	retinoic acid receptor alpha	Homo sapiens	58-62
30992691-12	2019	Elevated RNF8 expression promotes the interaction between RARA and RNF8 and induces RARA Lys-48 linkage ubiquitylation and degradation, resulting in attenuated transcriptional activation of RARA.	Lysine	89-92	retinoic acid receptor alpha	Homo sapiens	84-88
35230082-5	2022	Using this unnatural amino acid mutagenesis approach, we find that threonylation of Lys162 of Aurora kinase A inhibits its kinase activity both in vitro and in vivo and that the inhibitory effect can be reversed by the deacetylase Sirtuin 3, which removes the threonylated group from the lysine.	Lysine	288-294	aurora kinase A	Homo sapiens	94-109
30992691-12	2019	Elevated RNF8 expression promotes the interaction between RARA and RNF8 and induces RARA Lys-48 linkage ubiquitylation and degradation, resulting in attenuated transcriptional activation of RARA.	Lysine	89-92	retinoic acid receptor alpha	Homo sapiens	84-88
15767585-9	2005	In addition, biotin labeling of ROMK1 and R1K22R proteins expressed in HEK293 cells showed increased surface expression of the Lys-22 mutant channel.	Lysine	127-130	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	32-37
35182729-7	2022	Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance.	Lysine	138-144	acyl-CoA synthetase long chain family member 3	Homo sapiens	96-101
15615720-6	2005	We found that an IC(50) concentration (15 mum) of PLP modified a single IN residue, Lys(244), located in the C-terminal domain.	Lysine	84-87	pyridoxal phosphatase	Homo sapiens	50-53
35033534-1	2022	The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20-Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity.	Lysine	11-17	PHD finger protein 20	Homo sapiens	61-66
30817134-4	2019	Human MOCS3 is a dual-function protein that was shown to play an important role in Moco biosynthesis and in the mcm5s2U thio modifications of nucleosides in cytosolic tRNAs for Lys, Gln, and Glu.	Lysine	177-180	molybdenum cofactor synthesis 3	Homo sapiens	6-11
15615720-7	2005	In fact, we observed a correlation between interaction of PLP with Lys(244) and the compound"s ability to impair formation of the IN.DNA complex.	Lysine	67-70	pyridoxal phosphatase	Homo sapiens	58-61
30631154-2	2019	Here, we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.	Lysine	62-69	phosphatase and tensin homolog	Homo sapiens	54-58
15732101-5	2005	We have identified four mutations in senataxin in the French-Canadian population including two novel missense mutations: the 5927T--&gt;G mutation changes the leucine encoded by codon 1976 to an arginine in the helicase domain (L1976R), and the 193G--&gt;A mutation changes a glutamic acid encoded by codon 65 into a lysine in the N-terminal domain of the protein (E65K).	Lysine	317-323	senataxin	Homo sapiens	37-46
30842237-6	2019	Mechanistically, KAT8 directly interacts with IRF3 and mediates IRF3 acetylation at lysine 359 via its MYST domain.	Lysine	84-90	K(lysine) acetyltransferase 8	Mus musculus	17-21
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	145-151	ovo like zinc finger 2	Mus musculus	75-80
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	157-163	ovo like zinc finger 2	Mus musculus	75-80
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	157-163	ovo like zinc finger 2	Mus musculus	75-80
30858356-3	2019	Here we report that p53 is modified by kbhb and that this modification occurs at lysines 120, 319, and 370 of p53.	Lysine	81-88	transformation related protein 53, pseudogene	Mus musculus	20-23
35301489-5	2022	The acetylated Ada3 lysine residues are bound by bromodomains within SAGA subunits Gcn5 and Spt7 that synergistically facilitate formation of SAGA homo-dimers.	Lysine	20-26	SAGA histone acetyltransferase complex subunit SPT7	Saccharomyces cerevisiae S288C	92-96
35137160-0	2022	Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation.	Lysine	105-111	PR/SET domain 9	Homo sapiens	8-33
35169119-1	2022	The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation of histone H3 on lysine 27 residue (H3K27me3).	Lysine	186-192	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	78-83
30858356-3	2019	Here we report that p53 is modified by kbhb and that this modification occurs at lysines 120, 319, and 370 of p53.	Lysine	81-88	transformation related protein 53, pseudogene	Mus musculus	110-113
15769092-7	2005	Furthermore, PEG(2k)-Lys-GLP-1 was clearly resistant to purified DPP-IV in buffer with 50-fold increased half-life compared to unmodified GLP-1.	Lysine	21-24	dipeptidylpeptidase 4	Rattus norvegicus	65-71
30814730-8	2019	NR4A1 binding also promotes acetylation of histone 3 at lysine 27 (H3K27ac), leading to activation of tolerance-related genes.	Lysine	56-62	nuclear receptor subfamily 4, group A, member 1	Mus musculus	0-5
15737740-6	2005	Cell detachment is inhibited by carboxypeptidase B (CPB), an enzyme that blocks plasmin formation by cleaving off C-terminal lysine residues.	Lysine	125-131	carboxypeptidase B1 (tissue)	Mus musculus	32-50
30792382-5	2019	We also confirmed suppressor of variegation 4-20 homolog 2 (SUV420H2), which is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4 (H4K20), as the target of miR-29a.	Lysine	140-143	lysine methyltransferase 5C	Homo sapiens	18-58
30792382-5	2019	We also confirmed suppressor of variegation 4-20 homolog 2 (SUV420H2), which is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4 (H4K20), as the target of miR-29a.	Lysine	140-143	lysine methyltransferase 5C	Homo sapiens	60-68
35018834-4	2022	Using site directed mutagenesis, two lysine residues were inserted into variable loop VIII of the AAV serotype 5 capsid vector (AAV5-PK2).	Lysine	37-43	cytochrome c oxidase subunit 8A	Homo sapiens	86-90
30792382-5	2019	We also confirmed suppressor of variegation 4-20 homolog 2 (SUV420H2), which is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4 (H4K20), as the target of miR-29a.	Lysine	140-143	H4 clustered histone 6	Homo sapiens	150-160
15737740-6	2005	Cell detachment is inhibited by carboxypeptidase B (CPB), an enzyme that blocks plasmin formation by cleaving off C-terminal lysine residues.	Lysine	125-131	carboxypeptidase B1 (tissue)	Mus musculus	52-55
30792382-5	2019	We also confirmed suppressor of variegation 4-20 homolog 2 (SUV420H2), which is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4 (H4K20), as the target of miR-29a.	Lysine	140-143	microRNA 29a	Homo sapiens	187-194
35115713-1	2022	SETD2 is a histone H3 lysine 36 (H3K36) trimethyltransferase that is mutated with high prevalence (13%) in clear cell renal cell carcinoma (ccRCC).	Lysine	22-28	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
15629119-6	2005	Instead, we suggest that the conserved Glu, Lys, and Asn residues of the N-box contribute to coordinating Mg2+ in a position critical for formation of the PDK-MgATP-substrate ternary complex.	Lysine	44-47	pyruvate dehydrogenase kinase	Arabidopsis thaliana	155-158
34951461-2	2022	Mono-ubiquitination at Lysine 119 of H2A (ubH2A) has been suggested to repress transcription by preventing the recruitment of FACT at early elongation process.	Lysine	23-29	H2A clustered histone 18	Homo sapiens	37-40
29631413-6	2019	Augmented PPARalpha in hypertrophied myocytes revealed downregulated p53 acetylation (lys 382), leading to reduced apoptosis.	Lysine	86-89	peroxisome proliferator activated receptor alpha	Homo sapiens	10-19
15660834-8	2005	CONCLUSIONS: The absence of the high-prevalence antigen STAR detected by the proband"s antibody is likely associated with lysine at Position 47 of the Sc glycoprotein.	Lysine	122-128	steroidogenic acute regulatory protein	Homo sapiens	56-60
30661771-1	2019	Hypusine is formed post-translationally from lysine and is found in a single cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolog eIF5A2.	Lysine	45-51	eukaryotic translation initiation factor 5A	Homo sapiens	95-138
30661771-1	2019	Hypusine is formed post-translationally from lysine and is found in a single cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolog eIF5A2.	Lysine	45-51	eukaryotic translation initiation factor 5A	Homo sapiens	140-145
34453169-5	2022	Bisulphite sequencing demonstrated hypermethylation in the promoter region of PAX1 (35%; 14/40) and lower levels of histone 3 lysine 9 acetylation (H3K9ac) were observed on the promoter region of PAX1 (6-fold; P< 0.004) in parathyroid adenomas.	Lysine	126-132	paired box 1	Homo sapiens	196-200
15768552-2	2005	It was found in a compound heterozygous state with other mutations producing beta-thalassemia (thal) or Hb E [beta26(B8)Glu--&gt;Lys].	Lysine	129-132	hemoglobin subunit epsilon 1	Homo sapiens	104-108
34999729-8	2022	Both IL-15 and Kdm6b-mediated demethylation of histone 3 at lysine 27 are responsible for the maturation of TCRalphabeta+CD8alphaalpha+ IELs through upregulating the expression of Gzmb and Fasl.	Lysine	60-66	granzyme B	Mus musculus	180-184
15826377-2	2005	We determined the crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the conserved core of lysine-type PGNs.	Lysine	166-172	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	54-57
35018374-4	2022	SIRT5 is an NAD-dependent protein deacylase critical for cellular metabolism that removes succinyl and malonyl groups from lysine residues.	Lysine	123-129	sirtuin 5	Homo sapiens	0-5
30526028-0	2019	Experimental and theoretical investigations of infrared multiple photon dissociation spectra of lysine complexes with Zn2+ and Cd2.	Lysine	96-102	CD2 molecule	Homo sapiens	127-130
30691485-9	2019	The interaction of the up-regulated HDAC7 with beta-catenin led to a decrease in beta-catenin acetylation level at Lys-49, followed by a decrease in beta-catenin phosphorylation level at Ser-45.	Lysine	115-118	histone deacetylase 7	Homo sapiens	36-41
30691485-9	2019	The interaction of the up-regulated HDAC7 with beta-catenin led to a decrease in beta-catenin acetylation level at Lys-49, followed by a decrease in beta-catenin phosphorylation level at Ser-45.	Lysine	115-118	catenin beta 1	Homo sapiens	47-59
30691485-9	2019	The interaction of the up-regulated HDAC7 with beta-catenin led to a decrease in beta-catenin acetylation level at Lys-49, followed by a decrease in beta-catenin phosphorylation level at Ser-45.	Lysine	115-118	catenin beta 1	Homo sapiens	81-93
30691485-9	2019	The interaction of the up-regulated HDAC7 with beta-catenin led to a decrease in beta-catenin acetylation level at Lys-49, followed by a decrease in beta-catenin phosphorylation level at Ser-45.	Lysine	115-118	catenin beta 1	Homo sapiens	81-93
35070988-6	2021	Mechanistically, we found that INPP4B exerted its role via inhibiting the phosphorylation of Akt at lysine 473 but not threonine 308, which attenuated the activation of the PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway.	Lysine	100-106	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	31-37
35046941-4	2021	Furthermore, lysine residue 224 of KLF4 was acetylated by p300/CBP-associated factor (PCAF), which was important for KLF4-mediated transactivation.	Lysine	13-19	lysine acetyltransferase 2B	Rattus norvegicus	58-84
15993439-5	2005	Furthermore, we found that LY 487379, an mGluR2-specific allosteric modulator, significantly potentiated the inhibitory effect of DCG-IV on the excitatory transmission in the GP.	Lysine	27-29	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	41-47
35046941-4	2021	Furthermore, lysine residue 224 of KLF4 was acetylated by p300/CBP-associated factor (PCAF), which was important for KLF4-mediated transactivation.	Lysine	13-19	lysine acetyltransferase 2B	Rattus norvegicus	86-90
30545625-5	2019	Here we found that a triple helix fragment of hCOL3A1, Gly489-Gly510, contained multiple charged residues, as well as representative Glu-Lys-Gly and Glu-Arg-Gly charged triplets.	Lysine	137-140	collagen type III alpha 1 chain	Homo sapiens	46-53
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	10-16	H2B clustered histone 12	Rattus norvegicus	30-41
15894352-0	2005	Plasminogen interaction with platelets: the importance of carboxyterminal lysines.	Lysine	74-81	plasminogen	Homo sapiens	0-11
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	10-16	lysine acetyltransferase 2B	Rattus norvegicus	122-126
35046941-5	2021	Moreover, lysine residue 5 on histone H2B and lysine residue 9 on histone H3 at the IL-6 promoter were also acetylated by PCAF, which resulted in an increase in IL-6 transcription.	Lysine	46-52	lysine acetyltransferase 2B	Rattus norvegicus	122-126
30415967-3	2019	A few hot-spot lysines located in signature loops in ClpX were shown to be in proximity to several structural regions of ClpP providing an initial draft of the ClpX-ClpP interaction.	Lysine	15-22	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	121-125
30415967-3	2019	A few hot-spot lysines located in signature loops in ClpX were shown to be in proximity to several structural regions of ClpP providing an initial draft of the ClpX-ClpP interaction.	Lysine	15-22	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	165-169
15894352-11	2005	CONCLUSION: C-terminal lysines are necessary for high-affinity binding of plasminogen to platelets and for platelet-supported plasmin generation.	Lysine	23-30	plasminogen	Homo sapiens	74-85
30693017-13	2018	The MLL portion functions as a targeting module, which specifically binds chromatin containing di-/tri-methylated histone H3 lysine 36 and non-methylated CpGs.	Lysine	125-131	lysine methyltransferase 2A	Homo sapiens	4-7
15894352-11	2005	CONCLUSION: C-terminal lysines are necessary for high-affinity binding of plasminogen to platelets and for platelet-supported plasmin generation.	Lysine	23-30	plasminogen	Homo sapiens	74-81
15505811-5	2004	Besides the differences in loop flexibility and solvent accessibility, the dynamic stabilities of the hydrogen bonds between the inhibitors and the side chain of the lysine residue at the bottom of the active site also correlate well with the relative binding affinities of the inhibitors for the two CDKs.	Lysine	166-172	cyclin dependent kinase 2	Homo sapiens	301-305
30446621-7	2019	In human CD147, binding of CAIV was mediated by the negatively charged Glu-73 and in rat CD147 by the positively charged Lys-73.	Lysine	121-124	basigin (Ok blood group)	Homo sapiens	89-94
30346598-5	2019	Down-regulation of miR319A in jaw-1D* was linked to elevated levels of histone H3 lysine 9 dimethylation and DNA methylation at the CaMV35S enhancer located within the activation-tagging T-DNA of the jaw-1D locus.	Lysine	82-88	MIR319a	Arabidopsis thaliana	19-26
15572695-4	2004	Keap1 assembles into a functional E3 ubiquitin ligase complex with Cul3 and Rbx1 that targets multiple lysine residues located in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation both in vivo and in vitro.	Lysine	103-109	cullin 3	Homo sapiens	67-71
30361468-7	2019	We found that Ssh4-Rsp5 can target and ubiquitinate multiple lysines within a restricted distance from the membrane, providing a fail-safe mechanism for a diverse cargo repertoire.	Lysine	61-68	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	19-23
30431069-0	2019	Long non-coding RNA HOTAIR mediates the switching of histone H3 lysine 27 acetylation to methylation to promote epithelial-to-mesenchymal transition in gastric cancer.	Lysine	64-70	HOX transcript antisense RNA	Homo sapiens	20-26
30431069-2	2019	In this study, we propose a novel mechanism through which HOTAIR promotes EMT by switching histone H3 lysine 27 acetylation to methylation at the E-cadherin promoter, which induces the transcriptional inhibition of E-cadherin.	Lysine	102-108	HOX transcript antisense RNA	Homo sapiens	58-64
30431069-3	2019	HOTAIR recruits polycomb repressive complex 2 (PRC2) to catalyze H3K27me3; however, whether HOTAIR is associated with the acetylation of histone H3 lysine 27, a marker of transcriptional activation, and the mechanisms through which HOTAIR triggers the metastasis of gastric cancer (GC) by epigenetic regulation remain largely unknown.	Lysine	148-154	HOX transcript antisense RNA	Homo sapiens	0-6
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Lysine	120-123	matrix metallopeptidase 14	Homo sapiens	188-195
30453113-4	2019	Here, we analysis the structural effects of 4-HNE modification through formation of Michael adducts of Cys-4HNE, His-4HNE and Lys-4HNE on Serum Albumin (BSA) and Thioredoxin (TRX).	Lysine	126-129	thioredoxin	Homo sapiens	162-173
15550243-0	2004	Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.	Lysine	26-32	crumbs cell polarity complex component 2	Homo sapiens	60-64
30453113-4	2019	Here, we analysis the structural effects of 4-HNE modification through formation of Michael adducts of Cys-4HNE, His-4HNE and Lys-4HNE on Serum Albumin (BSA) and Thioredoxin (TRX).	Lysine	126-129	thioredoxin	Homo sapiens	175-178
29925903-1	2019	Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372.	Lysine	169-175	transformation related protein 53, pseudogene	Mus musculus	127-130
29925903-5	2019	However, only KO cells have elevated levels of Lysine 372 methylated p53.	Lysine	47-53	transformation related protein 53, pseudogene	Mus musculus	69-72
15371436-3	2004	The prototypic furin recognition cleavage site is Arg-X-Arg/Lys-Arg.	Lysine	60-63	furin, paired basic amino acid cleaving enzyme	Homo sapiens	15-20
31087300-0	2019	Analysis of DNA Processing Enzyme FEN1 and Its Regulation by Protein Lysine Acetylation.	Lysine	69-75	flap structure-specific endonuclease 1	Homo sapiens	34-38
15550569-3	2004	Here, we show that the orphan nuclear receptor SHP (small heterodimer partner), a coregulator that inhibits the activity of several nuclear receptors, can associate with unmodified and lysine 9-methylated histone-3, but not with the acetylated protein.	Lysine	185-191	nuclear receptor subfamily 0 group B member 2	Homo sapiens	23-50
30336354-6	2019	Increased MAO-A levels result in increased Lysine-63 linked ubiquitination of mitochondrial proteins and promotes autophagy through Bcl-2 phosphorylation.	Lysine	43-49	monoamine oxidase A	Homo sapiens	10-15
15550569-3	2004	Here, we show that the orphan nuclear receptor SHP (small heterodimer partner), a coregulator that inhibits the activity of several nuclear receptors, can associate with unmodified and lysine 9-methylated histone-3, but not with the acetylated protein.	Lysine	185-191	nuclear receptor subfamily 0 group B member 2	Homo sapiens	52-77
15284123-7	2004	Increased histone 3 Lysine 9 (H3-K9) methylation was observed in the promoter region of the IgH locus in L428 and L1236 cells.	Lysine	20-26	immunoglobulin heavy locus	Homo sapiens	92-95
30672443-7	2018	XPD Lys+ was significantly more common in the patient group than in the control group, and a two-fold increased risk for disease was determined.	Lysine	4-8	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-3
30361438-5	2018	Moreover, we observed RNF31 directly interact with cFLIP, and LUBAC further conjugated M1-linked ubiquitination chains at Lys-351 and Lys-353 of cFLIP to stabilize cFLIP, thereby protecting cells from TNFalpha-induced apoptosis.	Lysine	134-137	ring finger protein 31	Homo sapiens	22-27
15342649-4	2004	First, AMPK triggered the acetylation of importin alpha1 on Lys(22), a process dependent on the acetylase activity of p300.	Lysine	60-63	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	7-11
30566427-4	2018	We further show that PPARgamma is a direct substrate of Smurf1-mediated non-proteolytic lysine 63 (K63)-linked ubiquitin modification that suppresses its transcriptional activity, and treatment of Smurf1-deficient mice with a PPARgamma antagonist, GW9662, completely reversed the lipid accumulation in the liver.	Lysine	88-94	SMAD specific E3 ubiquitin protein ligase 1	Mus musculus	56-62
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Lysine	134-140	uncharacterized protein	Chlamydomonas reinhardtii	53-57
15342649-4	2004	First, AMPK triggered the acetylation of importin alpha1 on Lys(22), a process dependent on the acetylase activity of p300.	Lysine	60-63	E1A binding protein p300	Homo sapiens	118-122
30251657-7	2018	NMR data demonstrate that the recombinant domains of THB2 and THB4 coordinate the ferrous heme iron with the proximal histidine and a lysine from the distal helix.	Lysine	134-140	uncharacterized protein	Chlamydomonas reinhardtii	62-66
30251657-8	2018	An X-ray structure of ferric THB4 confirms lysine coordination.	Lysine	43-49	uncharacterized protein	Chlamydomonas reinhardtii	29-33
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Lysine	188-194	serine protease 8	Homo sapiens	74-83
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Lysine	232-238	serine protease 8	Homo sapiens	74-83
30098999-4	2018	Our results show that knockdown of FolR1 and/or Rfc1 reduced the abundance of histone H3 lysine and DNA methylation, two epigenetic modifications that play an important role during neural and neural crest development.	Lysine	89-95	folate receptor alpha	Homo sapiens	35-40
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Lysine	232-238	serine protease 8	Homo sapiens	74-83
15537541-5	2004	At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association.	Lysine	101-107	cullin associated and neddylation dissociated 1	Homo sapiens	22-27
30809370-5	2019	Crystallographic studies of peptide-MDM2/MDMX complexes structurally validated the chemoselectivity of the dithiocarbamate staple bridging Lys and Cys at (i, i + 4) positions.	Lysine	139-142	MDM4 regulator of p53	Homo sapiens	41-45
15537541-5	2004	At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association.	Lysine	101-107	cullin 1	Homo sapiens	96-100
15537541-5	2004	At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association.	Lysine	101-107	NEDD8 ubiquitin like modifier	Homo sapiens	167-172
15537541-5	2004	At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association.	Lysine	101-107	cullin associated and neddylation dissociated 1	Homo sapiens	191-196
15537541-5	2004	At the other end, two Cand1 HEAT repeats pack against a conserved Cul1 surface cleft and bury a Cul1 lysine residue, whose modification by the ubiquitin-like protein, Nedd8, is able to block Cand1-Cul1 association.	Lysine	101-107	cullin 1	Homo sapiens	96-100
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	89-92	small ubiquitin like modifier 1	Homo sapiens	66-72
15465032-8	2004	Altogether, we demonstrate that HIF-1alpha is upregulated through SUMO-1 modification at Lys(391)/Lys(477) residues, which may stabilize HIF-1alpha and enhance its transcriptional activity.	Lysine	98-101	small ubiquitin like modifier 1	Homo sapiens	66-72
15528149-0	2004	Generation of transgenic mice expressing human hemoglobin E. Hemoglobin E (HbE, beta26 Glu--&gt;Lys) is the most common abnormal Hb variant in the world, and found in greatest frequency in Southeast (SE) Asia.	Lysine	96-99	hemoglobin subunit epsilon 1	Homo sapiens	75-78
15574848-2	2004	Ectopic expression of NtSET1 causes an increase in methylated histone H3 lysine 9 and abnormal chromosome segregation in tobacco suspension cells, and inhibits tobacco plant growth.	Lysine	73-79	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1	Nicotiana tabacum	22-28
15684686-5	2004	The current experiments analyze the interactions of isolated human neutrophils with PEG hydrogels modified with Arg-Gly-Asp-Ser (RGDS), a known ligand for some beta(1) and beta(3) integrins, and Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Thr-Ile-Gly-Gly (TMKIIPFNRLTIGG), a ligand for Mac-1, a beta(2) integrin.	Lysine	203-206	ral guanine nucleotide dissociation stimulator	Homo sapiens	129-133
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	143-149	nerve growth factor	Rattus norvegicus	61-80
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	143-149	nerve growth factor	Rattus norvegicus	82-85
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	151-154	nerve growth factor	Rattus norvegicus	61-80
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	151-154	nerve growth factor	Rattus norvegicus	82-85
15470133-8	2004	Mutation of lysine-133 in the extracellular domain of the ASIC1a subunit abolishes the high-affinity Zn2+ inhibition.	Lysine	12-18	acid-sensing (proton-gated) ion channel 1	Mus musculus	58-64
15272016-5	2004	Without a predisposition to searching for the expected isopeptides based on calculated molecular mass and relying instead on the characteristic MS/MS fragmentation pattern to identify sumolylation, we demonstrate that several other lysine residues located not within the perfect consensus sumoylation motif psiKXE/D, where psi represents a large hydrophobic amino acid, and X represents any amino acid, can be sumolylated with a reconstituted in vitro system containing only the SUMO proteins, E1-activating enzyme and E2-conjugating enzyme (Ubc9).	Lysine	232-238	ubiquitin conjugating enzyme E2 I	Homo sapiens	542-546
15315443-5	2004	The calculations also help to explain the absence of positively charged Lys/Arg side chains in the anion-binding sites of SBP and ModA.	Lysine	72-75	selenium binding protein 1	Homo sapiens	122-125
15199058-0	2004	The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition.	Lysine	18-21	Fc epsilon receptor II	Homo sapiens	68-72
15199058-6	2004	Lysine 352 within the A-B loop was identified as contributing directly to human CD23 interaction.	Lysine	0-6	Fc epsilon receptor II	Homo sapiens	80-84
15297880-4	2004	In this study, we demonstrate that interaction of the human SRY with histone acetyltransferase p300 induces the acetylation of SRY both in vitro and in vivo at a single conserved lysine residue.	Lysine	179-185	E1A binding protein p300	Homo sapiens	69-99
15152012-4	2004	Three independent methods were used in this report to address the question of the protonation state of this important lysine (Lys-73) in the TEM-1 beta-lactamase from Escherichia coli.	Lysine	118-124	TEM-1 beta-lactamase	Escherichia coli	141-161
15152012-4	2004	Three independent methods were used in this report to address the question of the protonation state of this important lysine (Lys-73) in the TEM-1 beta-lactamase from Escherichia coli.	Lysine	126-129	TEM-1 beta-lactamase	Escherichia coli	141-161
15180994-0	2004	Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.	Lysine	13-19	galactokinase	Saccharomyces cerevisiae S288C	112-119
15180994-4	2004	Methylation of lysine 4 of H3 via Set1, a component of the Saccharomyces cerevisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquitination Rad6-Bre1 complexes, which are required for the expression of a subset of genes.	Lysine	15-21	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	190-194
15163661-4	2004	Mutagenesis of lysine residues within the putative nuclear localization region (amino acids 68-82) directs Id1(NLS) to the cytoplasm yet confers an increased rate of degradation (t(1/2) approximately 0.5 h).	Lysine	15-21	inhibitor of DNA binding 1, HLH protein	Homo sapiens	107-110
15163661-5	2004	Id1 in which all lysine residues were mutagenized to alanine (lysineless Id1) was also rapidly degraded (t(1/2) approximately 0.6 h).	Lysine	17-23	inhibitor of DNA binding 1, HLH protein	Homo sapiens	0-3
15163661-6	2004	Addition of a Myc(6) tag to the N terminus of lysine-less Id1 markedly stabilized Id1 (t(1/2) &gt; 10 h) and suggests degradation via the N terminus-dependent pathway.	Lysine	46-52	inhibitor of DNA binding 1, HLH protein	Homo sapiens	58-61
15163661-6	2004	Addition of a Myc(6) tag to the N terminus of lysine-less Id1 markedly stabilized Id1 (t(1/2) &gt; 10 h) and suggests degradation via the N terminus-dependent pathway.	Lysine	46-52	inhibitor of DNA binding 1, HLH protein	Homo sapiens	82-85
15166213-2	2004	Among the phenotypes of Saccharomyces cerevisiae mutants lacking CuZn-superoxide dismutase (Sod1p) is an aerobic lysine auxotrophy; in the current work we show an additional leaky auxotrophy for leucine.	Lysine	113-119	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	92-97
15166213-9	2004	Thus, we conclude that when Sod1p is absent a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originates in the intermembrane space and diffuses across the inner membrane.	Lysine	46-52	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	28-33
15191526-2	2004	This new allele is identical to MICB-0103101v except for a single mutation of G to A in exon 4 that translates into an amino acid substitution from glutamic acid to lysine.	Lysine	165-171	MHC class I polypeptide-related sequence B	Homo sapiens	32-36
15182962-1	2004	Persons who have the Glu-487--&gt;Lys mutation (single nucleotide polymorphism) of the aldehyde dehydrogenase-2 (ALDH2) gene have less ability to metabolize the alcohol breakdown product acetaldehyde.	Lysine	34-37	aldehyde dehydrogenase 2 family member	Homo sapiens	87-111
15182962-1	2004	Persons who have the Glu-487--&gt;Lys mutation (single nucleotide polymorphism) of the aldehyde dehydrogenase-2 (ALDH2) gene have less ability to metabolize the alcohol breakdown product acetaldehyde.	Lysine	34-37	aldehyde dehydrogenase 2 family member	Homo sapiens	113-118
15229330-1	2004	OBJECTIVE: To determine whether small ubiquitin-related modifier (SUMO)ylation of lysine 107 plays a role in regulating the activity of peroxisome proliferator-activated receptor gamma (PPARgamma).	Lysine	82-88	peroxisome proliferator activated receptor gamma	Mus musculus	136-184
15229330-1	2004	OBJECTIVE: To determine whether small ubiquitin-related modifier (SUMO)ylation of lysine 107 plays a role in regulating the activity of peroxisome proliferator-activated receptor gamma (PPARgamma).	Lysine	82-88	peroxisome proliferator activated receptor gamma	Mus musculus	186-195
15229330-4	2004	RESULTS: While examining PPARgamma2 for potential ubiquitylation sites, we identified a strong consensus site for SUMO modification that contains lysine 107.	Lysine	146-152	peroxisome proliferator activated receptor gamma	Mus musculus	25-35
15229330-5	2004	In vitro, SUMOylation studies showed that lysine 107 of PPARgamma2 is a major SUMOylation site and that at least one other SUMOylation site is present in PPARgamma.	Lysine	42-48	peroxisome proliferator activated receptor gamma	Mus musculus	56-66
15229330-5	2004	In vitro, SUMOylation studies showed that lysine 107 of PPARgamma2 is a major SUMOylation site and that at least one other SUMOylation site is present in PPARgamma.	Lysine	42-48	peroxisome proliferator activated receptor gamma	Mus musculus	56-65
15229330-7	2004	DISCUSSION: These results indicated that SUMOylation plays a role in regulating PPARgamma, both indirectly and directly by modification of lysine 107.	Lysine	139-145	peroxisome proliferator activated receptor gamma	Mus musculus	80-89
15144222-10	2004	Glucose 6-phosphate dehydrogenase was inactivated partially by glyoxylate when reactants were reduced with sodium borodeuteride, which may indicate that glyoxylate reacts with selective lysine epsilon-amino groups.	Lysine	186-192	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
32688904-5	2004	The metabolism of lysine was also studied by analysis of the enzymes aspartate kinase, homoserine dehydrogenase, lysine 2-oxoglutarate reductase and saccharopine dehydrogenase, which exhibited major changes in activity, depending on the genotype, suggesting that the mutant genes may have distinct regulatory activities.	Lysine	18-24	Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410	Zea mays	149-175
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Lysine	150-156	carboxypeptidase B1 (tissue)	Mus musculus	68-86
14715654-1	2004	Activated thrombin-activable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase B-like plasma enzyme that can slow clot lysis by removing lysine residues exposed on fibrin as it is cleaved by plasmin.	Lysine	140-146	carboxypeptidase B2	Homo sapiens	10-51
14715654-1	2004	Activated thrombin-activable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase B-like plasma enzyme that can slow clot lysis by removing lysine residues exposed on fibrin as it is cleaved by plasmin.	Lysine	140-146	plasminogen	Homo sapiens	194-201
14718541-4	2004	On poly-d-lysine-coated dishes, endogenous MOCA is concentrated on the leading edge of broad membrane protrusions (lamellipodia) where actin filaments are co-localized.	Lysine	10-16	dedicator of cytokinesis 3	Homo sapiens	43-47
15084912-5	2004	Peptide binding studies revealed that the majority of the CII-peptide binding affinity for DR1 and DR4 is controlled by the Phe at 263 and, unexpectedly, the adjacent Lys.	Lysine	167-170	serpin family D member 1	Homo sapiens	58-61
30458018-0	2018	Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.	Lysine	0-6	solute carrier family 35 member B4	Homo sapiens	102-109
15084912-5	2004	Peptide binding studies revealed that the majority of the CII-peptide binding affinity for DR1 and DR4 is controlled by the Phe at 263 and, unexpectedly, the adjacent Lys.	Lysine	167-170	down-regulator of transcription 1	Homo sapiens	91-94
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	117-120	WD repeat domain 77	Homo sapiens	108-113
15066178-5	2004	Using heparin affinity chromatography, commonly employed in such studies, we define three clusters of arginines and lysines of CCP3, which are important for the interaction of PAPP-A with heparin.	Lysine	116-123	pappalysin 1	Homo sapiens	176-182
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	117-120	WD repeat domain 77	Homo sapiens	153-158
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	127-130	WD repeat domain 77	Homo sapiens	108-113
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	127-130	WD repeat domain 77	Homo sapiens	153-158
30259036-6	2018	Through direct binding to lysine residue 433, TA triggers the dissociation of PKM2 tetramers and further blocks the metabolic activity of PKM2.	Lysine	26-32	pyruvate kinase M1/2	Homo sapiens	78-82
15060161-2	2004	In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.	Lysine	94-100	E1A binding protein p300	Homo sapiens	62-66
30259036-6	2018	Through direct binding to lysine residue 433, TA triggers the dissociation of PKM2 tetramers and further blocks the metabolic activity of PKM2.	Lysine	26-32	pyruvate kinase M1/2	Homo sapiens	138-142
30389914-8	2018	Trimethylation (me3) of histone H3 lysine 27 (H3K27) is enriched in the Nmyc promoter upon Asxl1 overexpression, whereas it is downregulated in Asxl1-deleted lung and -depleted A549 cells, similar to H3K9me3, another repressive histone marker.	Lysine	35-41	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	72-76
30389914-8	2018	Trimethylation (me3) of histone H3 lysine 27 (H3K27) is enriched in the Nmyc promoter upon Asxl1 overexpression, whereas it is downregulated in Asxl1-deleted lung and -depleted A549 cells, similar to H3K9me3, another repressive histone marker.	Lysine	35-41	ASXL transcriptional regulator 1	Mus musculus	91-96
30389914-8	2018	Trimethylation (me3) of histone H3 lysine 27 (H3K27) is enriched in the Nmyc promoter upon Asxl1 overexpression, whereas it is downregulated in Asxl1-deleted lung and -depleted A549 cells, similar to H3K9me3, another repressive histone marker.	Lysine	35-41	ASXL transcriptional regulator 1	Mus musculus	144-149
14688266-10	2004	Replacing Arg-1753 of Prp8 by either Lys, Ala, Gln, or Glu resulted in suppression of helicase-defective Prp22 mutants.	Lysine	37-40	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	22-26
29511337-10	2018	Interestingly, we determined that OCT4 was ubiquitinated at lysine 284, and CHIP overexpression did not degrade K284R mutant OCT4.	Lysine	60-66	POU class 5 homeobox 1	Homo sapiens	34-38
14688266-10	2004	Replacing Arg-1753 of Prp8 by either Lys, Ala, Gln, or Glu resulted in suppression of helicase-defective Prp22 mutants.	Lysine	37-40	DEAH-box ATP-dependent RNA helicase PRP22	Saccharomyces cerevisiae S288C	105-110
15014946-2	2004	Mutations of kryptonite cause a reduction of methylated histone H3 lysine 9, a loss of DNA methylation, and reduced gene silencing.	Lysine	67-73	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	13-23
30099093-7	2018	RESULTS: Overexpression of miR-132 decreased global histone 3 lysine 27 tri-methylation (H3K27me3), a repressive epigenetic mark.	Lysine	62-68	microRNA 132	Mus musculus	27-34
15014946-6	2004	In kryptonite mutants, dimethyl histone H3 lysine 9 is nearly completely lost, but monomethyl histone H3 lysine 9 levels are only slightly reduced.	Lysine	43-49	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	3-13
15014946-6	2004	In kryptonite mutants, dimethyl histone H3 lysine 9 is nearly completely lost, but monomethyl histone H3 lysine 9 levels are only slightly reduced.	Lysine	105-111	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	3-13
30270107-6	2018	This study revealed the existence of a DSB-induced monoubiquitination-to-acetylation switch on histone H2B lysine 120, likely mediated by the SAGA complex, as well as higher-order signaling at HR-repaired DSBs whereby histone H1 is evicted while ubiquitin and 53BP1 accumulate over the entire gammaH2AX domains.	Lysine	107-113	tumor protein p53 binding protein 1	Homo sapiens	260-265
15014946-7	2004	Recombinant KRYPTONITE can add one or two, but not three, methyl groups to the lysine 9 position of histone H3.	Lysine	79-85	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	12-22
30312172-1	2018	Methylation of histones H4 at lysine 20 position (H4K20me), which is functional in DNA repair, represents a binding site for the 53BP1 protein.	Lysine	30-36	tumor protein p53 binding protein 1	Homo sapiens	129-134
15014946-8	2004	Further, we identify a KRYPTONITE-related protein, SUVH6, which displays histone H3 lysine 9 methylation activity with a spectrum similar to that of KRYPTONITE.	Lysine	84-90	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	23-33
15014946-8	2004	Further, we identify a KRYPTONITE-related protein, SUVH6, which displays histone H3 lysine 9 methylation activity with a spectrum similar to that of KRYPTONITE.	Lysine	84-90	SU(VAR)3-9 homolog 6	Arabidopsis thaliana	51-56
15014946-8	2004	Further, we identify a KRYPTONITE-related protein, SUVH6, which displays histone H3 lysine 9 methylation activity with a spectrum similar to that of KRYPTONITE.	Lysine	84-90	histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4-like protein	Arabidopsis thaliana	149-159
15014946-9	2004	Our results suggest that multiple Su(var)3-9 family members are active in Arabidopsis and that dimethylation of histone H3 lysine 9 is the critical mark for gene silencing and DNA methylation.	Lysine	123-129	zinc finger (Ran-binding) family protein	Arabidopsis thaliana	34-44
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 1	Homo sapiens	44-47
14681216-1	2004	WNK1 belongs to a unique protein kinase family that lacks the catalytic lysine in its normal position.	Lysine	72-78	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 1	Homo sapiens	49-54
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 1	Homo sapiens	55-60
14559717-4	2004	On the contrary, apical uptake of glucose and lysine was increased in EGF-treated cells, indicating that EGF was not acting generally to decrease apical nutrient uptake mechanisms in the proximal tubule cells.	Lysine	46-52	epidermal growth factor like 1	Rattus norvegicus	70-73
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	4-7	coactosin-like 1 (Dictyostelium)	Mus musculus	20-25
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	4-7	coactosin-like 1 (Dictyostelium)	Mus musculus	129-134
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	88-91	coactosin-like 1 (Dictyostelium)	Mus musculus	20-25
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	88-91	coactosin-like 1 (Dictyostelium)	Mus musculus	129-134
14767880-7	2004	Here, we report that the replacement of Glu(9) of GLP-1 with Lys dramatically increased resistance to DPP IV.	Lysine	61-64	glucagon like peptide 1 receptor	Homo sapiens	50-55
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	chromobox 5	Homo sapiens	76-107
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	chromobox 5	Homo sapiens	109-117
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	182-187
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	291-296
14767880-9	2004	We investigated the in vivo antagonistic actions of (Lys(9))GLP-1 in comparison with GLP-1(9-36)amide and exendin (9-39) and revealed that this novel analogue may serve as a functional antagonist of the GLP-1 receptor.	Lysine	53-56	glucagon like peptide 1 receptor	Homo sapiens	60-65
30253283-4	2018	In previous studies, amino acid residues Lys340, Lys 384, Glu417 and Glu511 of TRAF6 were identified as the most vital residues on the basis of their contributions to interaction energy, relative solvent accessibility and electrostatic interactions in the TRAF6-Basigin protein-protein interaction (PPI) scheme.	Lysine	41-44	TNF receptor associated factor 6	Homo sapiens	79-84
14693378-4	2004	The tandem repeat sequence of Lys-Lys-Lys-Lys-Glu-Glu-Glu-Glu characteristic of the C-terminal region of S. cerevisiae Mnn4p is not present in Pno1p.	Lysine	30-33	Mnn4p	Saccharomyces cerevisiae S288C	119-124
30253283-4	2018	In previous studies, amino acid residues Lys340, Lys 384, Glu417 and Glu511 of TRAF6 were identified as the most vital residues on the basis of their contributions to interaction energy, relative solvent accessibility and electrostatic interactions in the TRAF6-Basigin protein-protein interaction (PPI) scheme.	Lysine	41-44	TNF receptor associated factor 6	Homo sapiens	256-261
30253283-4	2018	In previous studies, amino acid residues Lys340, Lys 384, Glu417 and Glu511 of TRAF6 were identified as the most vital residues on the basis of their contributions to interaction energy, relative solvent accessibility and electrostatic interactions in the TRAF6-Basigin protein-protein interaction (PPI) scheme.	Lysine	41-44	basigin (Ok blood group)	Homo sapiens	262-269
14693378-4	2004	The tandem repeat sequence of Lys-Lys-Lys-Lys-Glu-Glu-Glu-Glu characteristic of the C-terminal region of S. cerevisiae Mnn4p is not present in Pno1p.	Lysine	34-37	Mnn4p	Saccharomyces cerevisiae S288C	119-124
14693378-4	2004	The tandem repeat sequence of Lys-Lys-Lys-Lys-Glu-Glu-Glu-Glu characteristic of the C-terminal region of S. cerevisiae Mnn4p is not present in Pno1p.	Lysine	34-37	Mnn4p	Saccharomyces cerevisiae S288C	119-124
14693378-4	2004	The tandem repeat sequence of Lys-Lys-Lys-Lys-Glu-Glu-Glu-Glu characteristic of the C-terminal region of S. cerevisiae Mnn4p is not present in Pno1p.	Lysine	34-37	Mnn4p	Saccharomyces cerevisiae S288C	119-124
30224647-0	2018	De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.	Lysine	83-89	MSL complex subunit 3	Homo sapiens	21-25
30224647-3	2018	Here, we report pathogenic variations in MSL3, which encodes a member of the chromatin-associated male-specific lethal (MSL) complex responsible for bulk histone H4 lysine 16 acetylation (H4K16ac) in flies and mammals.	Lysine	165-171	MSL complex subunit 3	Homo sapiens	41-45
12962541-9	2004	The computed simulations detailing the docking of Pi1 peptides on to the Kv1.2 channels support an unexpected key role of specific basic amino acid residues, which form a basic ring (Arg-5, Arg-12, Arg-28 and Lys-31 residues), in toxin binding.	Lysine	209-212	Pancreas inflammation QTL 1	Rattus norvegicus	50-53
30268116-0	2018	Acetylation of C-terminal lysines modulates protein turnover and stability of Connexin-32.	Lysine	26-33	gap junction protein, beta 1	Mus musculus	78-89
30268116-9	2018	Mutational analysis demonstrates that these lysines are involved in the regulation of Cx32 ubiquitination and turnover.	Lysine	44-51	gap junction protein, beta 1	Mus musculus	86-90
30268116-11	2018	CONCLUSION: Taken together these results highlight the role of post translational modifications and lysines in the C-terminal tail of Cx32 in the fine-tuning of Cx32 protein stability and channel-independent functions.	Lysine	100-107	gap junction protein, beta 1	Mus musculus	134-138
15068667-6	2004	We observed that Lys-105 and Arg-109 are critical for IL13 binding to IL13Ralpha2, indeed.	Lysine	17-20	interleukin 13 receptor subunit alpha 2	Homo sapiens	70-81
30268116-11	2018	CONCLUSION: Taken together these results highlight the role of post translational modifications and lysines in the C-terminal tail of Cx32 in the fine-tuning of Cx32 protein stability and channel-independent functions.	Lysine	100-107	gap junction protein, beta 1	Mus musculus	161-165
14506259-3	2003	The catalytic efficiency of CDK2-cyclin A is impaired 2000-, 10-, and 150-fold, when Pro+1, Lys+2, or Lys+3, respectively, is substituted with Ala in a short synthetic peptide substrate.	Lysine	92-95	cyclin dependent kinase 2	Homo sapiens	28-32
14506259-4	2003	Yet, in physiological substrates of both CDK2-cyclin A and CDK2-cyclin E, it is found that Lys+2, and, occasionally, both Lys+2 and Lys+3 together are replaced with suboptimal determinants.	Lysine	91-94	cyclin dependent kinase 2	Homo sapiens	41-45
30108173-7	2018	We found that the lysine residues within the tropoelastin sequence were simultaneously unmodified and involved in various types of cross-links with different other domains.	Lysine	18-24	elastin	Bos taurus	45-57
14506259-4	2003	Yet, in physiological substrates of both CDK2-cyclin A and CDK2-cyclin E, it is found that Lys+2, and, occasionally, both Lys+2 and Lys+3 together are replaced with suboptimal determinants.	Lysine	91-94	cyclin dependent kinase 2	Homo sapiens	59-63
14506262-7	2003	This rearrangement allows lysines 44 and 46 to interact with the glycerol and cytosine phosphates of CDP-glycerol.	Lysine	26-33	cut like homeobox 1	Homo sapiens	101-104
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	78-84	lysine acetyltransferase 2B	Homo sapiens	24-28
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	150-157	lysine acetyltransferase 2B	Homo sapiens	24-28
29939350-6	2018	It was hypothesized 1) that the response to a decreasing digestible CP level could be described with broken line models and 2) that the break point of these models is dependent on the dietary SID Lys level.	Lysine	196-199	ceruloplasmin	Homo sapiens	68-70
29939350-8	2018	For G:F, the effect of decreasing CP level depended on the SID Lys level (P of the interaction = 0.028 in the linear model and P = 0.002 in the QP model).	Lysine	63-66	ceruloplasmin	Homo sapiens	34-36
14661947-5	2003	A comparison of these structures with tGcn5 bound to histone H3 reveals that the Gcn5/PCAF HATs can accommodate divergent substrates by utilizing analogous interactions with the lysine target and two C-terminal residues with a related chemical nature, suggesting that these interactions play a general role in Gcn5/PCAF substrate binding selectivity.	Lysine	178-184	lysine acetyltransferase 2B	Homo sapiens	86-90
29939350-9	2018	According to the BLL model, with 11 g SID Lys in the diet, G:F started to decline with CP levels < 176 g CP [SID Lys:CP = 0.062, SID Lys:apparent total tract digestible (ATTD) CP = 0.077], and with 10 g SID Lys, CP levels < 165 g/kg (SID Lys:CP = 0.061, SID Lys:ATTD CP = 0.075) depressed performance.	Lysine	42-45	ceruloplasmin	Homo sapiens	87-89
12917103-9	2003	In differentiating skeletal myocytes, SLIM1 overexpression induced hyperelongation, which, by either plating cells on poly-l-lysine or using a series of peptide blockade experiments, was shown to be specifically dependent on ligand binding to the alpha5beta1-integrin, whereas in reserve cells, SLIM1 overexpression induced the formation of multiple cytoplasmic protrusions (branching), which was also integrin mediated.	Lysine	118-131	four and a half LIM domains 1	Mus musculus	38-43
29947928-1	2018	The acetylation of the lysine 40 residue of alpha-tubulin was described more than 30 years ago and has been the subject of intense research ever since.	Lysine	23-29	tubulin alpha 1b	Homo sapiens	44-57
14653816-1	2003	The capacity of two maize opaque endosperm mutants (o1 and o2) and two floury (fl1 and fl2) to accumulate lysine in the seed in relation to their wild type counterparts Oh43+ was examined.	Lysine	106-112	zea floricaula/leafy 1	Zea mays	79-82
30154464-0	2018	Lysine benzoylation is a histone mark regulated by SIRT2.	Lysine	0-6	sirtuin 2	Homo sapiens	51-56
14653816-7	2003	The activities of the enzymes lysine 2-oxoglutate reductase and saccharopine dehydrogenase, both involved in lysine degradation in the maize endosperm were also determined and shown to be reduced several fold with the introduction of the o2, fl1 and fl2 mutations in the Oh43+ inbred line, whereas wild-type activity levels were verified in the Oh43o1 mutant.	Lysine	30-36	Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410	Zea mays	64-90
14653816-7	2003	The activities of the enzymes lysine 2-oxoglutate reductase and saccharopine dehydrogenase, both involved in lysine degradation in the maize endosperm were also determined and shown to be reduced several fold with the introduction of the o2, fl1 and fl2 mutations in the Oh43+ inbred line, whereas wild-type activity levels were verified in the Oh43o1 mutant.	Lysine	30-36	zea floricaula/leafy 1	Zea mays	242-245
30100186-1	2018	The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS).	Lysine	29-35	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	171-175
14622016-2	2003	ShK-Dap(22), a synthetic derivative in which a diaminopropionic acid residue has been substituted at position Lys(22), has been reported to be a selective K(v)1.3 inhibitor and to block this channel with equivalent potency as ShK [Kalman et al.	Lysine	110-113	death associated protein	Homo sapiens	4-7
29966721-5	2018	Bdnf transcription induced by BHBA stimulus was mediated through the cAMP/PKA-triggered phosphorylation of CREB (S133) and the subsequent up-regulation of histone H3 Lysine 27 acetylation (H3K27ac) binding at Bdnf promoters I, II, IV, and VI.	Lysine	166-172	brain derived neurotrophic factor	Mus musculus	0-4
14599798-5	2003	The substitution of key lysine residues with uncharged amino acids in NLS-2 blocked nuclear/nucleolar localization.	Lysine	24-30	phosphoserine aminotransferase 1	Homo sapiens	70-75
29777551-5	2018	METHODS: We have developed a new method for quantitative determination of human renalase, which is based on mass spectrometric detection of a proteotypic peptide containing S-terminal 13 C15 N-labelled lysine.	Lysine	202-208	renalase, FAD dependent amine oxidase	Homo sapiens	80-88
14573629-8	2003	In addition, the Lys-containing lactoferrin stimulated bovine tracheal epithelial cells to synthesize much higher levels of tracheal antimicrobial peptide mRNA than did the Arg-containing variant.	Lysine	17-20	tracheal antimicrobial peptide	Bos taurus	124-154
30089272-5	2018	Mechanistically, PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca2+ overload.	Lysine	84-90	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	17-23
30159125-1	2018	Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134 and enhance the formation of phosphorylated H2AX (gamma-H2AX), which causes chemoresistance of cancer cells.	Lysine	76-82	suppressor of variegation 3-9 2	Mus musculus	26-33
14551354-10	2003	Within the entire coding region of the XDH gene, an A to T base change at nucleotide position 2164 was identified in the siblings, indicating a nonsense substitution from AAG (Lys) to TAG (Tyr) at codon 722.	Lysine	176-179	xanthine dehydrogenase	Homo sapiens	39-42
30071900-7	2018	Molecularly, EZH2 interacted with PCNA via the PIP box and dimethylated PCNA at lysine 110.	Lysine	80-86	proliferating cell nuclear antigen	Homo sapiens	72-76
12881513-8	2003	Furthermore, increased pyridinoline cross-link levels were found in the matrix deposited by SSc fibroblasts, demonstrating a clear link between mRNA levels of the putative TLH gene (PLOD2) and the hydroxylation of lysine residues within the telopeptides.	Lysine	214-220	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	172-175
30094379-5	2018	We present evidence that SUMOylation of Glis3 by PIAS-family proteins occurs at two conserved lysine residues within the Glis3 N-terminus and modification of Glis3 by SUMO dramatically inhibited insulin transcription.	Lysine	94-100	GLIS family zinc finger 3	Homo sapiens	121-126
12881513-8	2003	Furthermore, increased pyridinoline cross-link levels were found in the matrix deposited by SSc fibroblasts, demonstrating a clear link between mRNA levels of the putative TLH gene (PLOD2) and the hydroxylation of lysine residues within the telopeptides.	Lysine	214-220	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	182-187
12888558-5	2003	Truncated CXCR2 receptors retained their ability to form oligomers only if the region between the amino acids Ala-106 and Lys-163 was present.	Lysine	122-125	C-X-C motif chemokine receptor 2	Homo sapiens	10-15
30022091-4	2018	MDC1 interacts mainly with EHMT1, which is facilitated by DNA damage-initiated ATM signalling, and EHMT2 dominantly modulates methylation of MDC1 lysine 45.	Lysine	146-152	ATM serine/threonine kinase	Homo sapiens	79-82
12816538-1	2003	To understand the structural basis of molecular elasticity and protein interaction of the elastic PEVK (Pro-Glu-Val-Lys) segment of the giant muscle protein titin, we carried out a detailed analysis of a representative PEVK module and a 16-module PEVK protein under various environmental conditions.	Lysine	116-119	titin	Homo sapiens	157-162
30016968-6	2018	Quantitative mass spectrometry, immunoprecipitation, ubiquitination assay, western blotting, and real-time RT-PCR were used to analyze the effects of Ube2v1 on histone H4 lysine 16 acetylation, interaction with Sirt1, ubiquitination of Sirt1, and autophagy-related gene expression.	Lysine	171-177	ubiquitin conjugating enzyme E2 V1	Homo sapiens	150-156
30016968-11	2018	Mechanistically, Ube2v1 promoted Ubc13-mediated ubiquitination and degradation of Sirt1 and inhibited histone H4 lysine 16 acetylation, and finally epigenetically suppressed autophagy gene expression in CRC.	Lysine	113-119	ubiquitin conjugating enzyme E2 N	Homo sapiens	33-38
12917322-6	2003	Conversion of lysine 36 to an unmethylatable arginine causes a decrease in the repression of GAL4 transcription, as does a Delta set2 mutation.	Lysine	14-20	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	93-97
30013113-0	2018	Correction: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.	Lysine	153-159	E2F transcription factor 1	Homo sapiens	45-49
12917322-7	2003	We further show that lysine 36 of histone H3 at GAL4 is methylated and that this methylation is dependent upon the presence of SET2.	Lysine	21-27	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	48-52
12754209-5	2003	MKP3 activation requires residues Tyr-111, Thr-116, Leu-119, Lys-149, Arg-189, Trp-190, Glu-218, Arg-223, Lys-229, and His-230 in the ERK2 substrate-binding region, located distal to the common docking site.	Lysine	61-64	dual specificity phosphatase 6	Homo sapiens	0-4
29803980-5	2018	METHODS: Conjugate was prepared by Lys-Lys cross-linking of thrombin with the phosphatidylserine-targeting ligand, annexin V.	Lysine	35-38	annexin A5	Homo sapiens	115-124
29803980-5	2018	METHODS: Conjugate was prepared by Lys-Lys cross-linking of thrombin with the phosphatidylserine-targeting ligand, annexin V.	Lysine	39-42	annexin A5	Homo sapiens	115-124
12754209-5	2003	MKP3 activation requires residues Tyr-111, Thr-116, Leu-119, Lys-149, Arg-189, Trp-190, Glu-218, Arg-223, Lys-229, and His-230 in the ERK2 substrate-binding region, located distal to the common docking site.	Lysine	106-109	dual specificity phosphatase 6	Homo sapiens	0-4
12724314-0	2003	Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.	Lysine	83-89	E1A binding protein p300	Homo sapiens	47-51
29741650-5	2018	RAD27 overexpressing cells were hypersensitive to treatment with DNA damaging agents, and defective in ubiquitinating the replication clamp proliferating cell nuclear antigen (PCNA) at lysine 164.	Lysine	185-191	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	0-5
29741650-5	2018	RAD27 overexpressing cells were hypersensitive to treatment with DNA damaging agents, and defective in ubiquitinating the replication clamp proliferating cell nuclear antigen (PCNA) at lysine 164.	Lysine	185-191	proliferating cell nuclear antigen	Homo sapiens	140-174
29741650-5	2018	RAD27 overexpressing cells were hypersensitive to treatment with DNA damaging agents, and defective in ubiquitinating the replication clamp proliferating cell nuclear antigen (PCNA) at lysine 164.	Lysine	185-191	proliferating cell nuclear antigen	Homo sapiens	176-180
12724314-5	2003	Consistent with the previous finding, lysines 370, 372, 373, 381, and 382 were detected by this modified selected ion tracing method as the target sites of p300 in vitro.	Lysine	38-45	E1A binding protein p300	Homo sapiens	156-160
12724314-7	2003	Immunoblotting using anti-acetyl-Lys-305 antibody confirmed this discovery and demonstrated that Lys-305 could be acetylated by p300 both in vitro and in vivo.	Lysine	33-36	E1A binding protein p300	Homo sapiens	128-132
12724314-7	2003	Immunoblotting using anti-acetyl-Lys-305 antibody confirmed this discovery and demonstrated that Lys-305 could be acetylated by p300 both in vitro and in vivo.	Lysine	97-100	E1A binding protein p300	Homo sapiens	128-132
29920217-5	2018	The DUSP14 triple-methylation mutant was impaired in PRMT5-mediated arginine methylation, TRAF2-mediated lysine ubiquitination, and DUSP14 phosphatase activity.	Lysine	105-111	dual specificity phosphatase 14	Homo sapiens	4-10
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	Lysine	99-105	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	94-97
12724314-9	2003	Thus, p300 may further regulate the transcriptional activity of p53 through a novel acetylation site, Lys-305.	Lysine	102-105	E1A binding protein p300	Homo sapiens	6-10
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-30	plasminogen	Homo sapiens	81-88
29712772-5	2018	Furthermore, we demonstrated that SOCS1- and SOCS3-bound IFN regulatory factor 7, a pivotal transcription factor of the TLR7 pathway, through the SH2 domain to promote its proteasomal degradation by lysine 48-linked polyubiquitination.	Lysine	199-205	suppressor of cytokine signaling 1	Homo sapiens	34-39
12871292-4	2003	These carboxy-terminal lysines are exposed upon limited proteolysis of fibrin by plasmin and act as ligands for the lysine-binding sites of plasminogen and tissue-type plasminogen activator (t-PA).	Lysine	23-29	plasminogen	Homo sapiens	81-88
12871292-5	2003	Elimination of these lysines by TAFIa abrogates the fibrin cofactor function of t-PA-mediated plasminogen activation, resulting in a decreased rate of plasmin generation and thus downregulation of fibrinolysis.	Lysine	21-28	plasminogen	Homo sapiens	94-101
29603199-10	2018	Furthermore, deacetylation of CypD at Lys residue by sirtuin 3 (SIRT3) caused its dissociation from ANT, contributing to an increase in mPT threshold in NAD+ -pretreated animals.	Lysine	38-41	sirtuin 3	Rattus norvegicus	53-62
12883629-5	2003	As the result, a novel SNP A(+884)-->G within the sixth exon of HL gene was found, the 276 codon AAA was changed into AGA and resulted in the substitution of arginine for lysine.	Lysine	171-177	lipase C, hepatic type	Homo sapiens	64-66
29603199-10	2018	Furthermore, deacetylation of CypD at Lys residue by sirtuin 3 (SIRT3) caused its dissociation from ANT, contributing to an increase in mPT threshold in NAD+ -pretreated animals.	Lysine	38-41	sirtuin 3	Rattus norvegicus	64-69
29963106-11	2018	The functional involvement of HDAC3 was related in part to the repression of miR-31 transcription via decreased histone H3 acetylation at lysine K9 levels of the miR-31 promoter.	Lysine	138-144	microRNA 31	Homo sapiens	77-83
29963106-11	2018	The functional involvement of HDAC3 was related in part to the repression of miR-31 transcription via decreased histone H3 acetylation at lysine K9 levels of the miR-31 promoter.	Lysine	138-144	microRNA 31	Homo sapiens	162-168
12876631-2	2003	The recently described thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin, thereby inhibiting tPA mediated plasminogen activation.	Lysine	128-134	carboxypeptidase B2	Homo sapiens	23-66
29506078-3	2018	Here we find that METTL3 is modified by SUMO1 mainly at lysine residues K177, K211, K212 and K215, which can be reduced by an SUMO1-specific protease SENP1.	Lysine	56-62	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	18-24
12876631-2	2003	The recently described thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin, thereby inhibiting tPA mediated plasminogen activation.	Lysine	128-134	carboxypeptidase B2	Homo sapiens	68-72
12788062-4	2003	Here, we report that SRF is modified by SUMO-1 chiefly at lysine(147) within the DNA-binding domain.	Lysine	58-64	small ubiquitin like modifier 1	Homo sapiens	40-46
29684271-6	2018	We then focused on investigating the effect of acetylation at lysine 280 (AcK280) on the structure, aggregation, and microtubule binding properties of Tau.	Lysine	62-68	microtubule associated protein tau	Homo sapiens	151-154
12676183-7	2003	Taken together, these data demonstrate that ubiquitylation of the cytoplasmic serine/threonine-rich region of the AT(1A) receptor on lysine residues is not required for its agonist-induced internalisation, and suggest that endocytosis of mammalian G protein-coupled receptors (GPCRs) occurs by a different mechanism than that of yeast GPCRs.	Lysine	133-139	angiotensin II receptor, type 1a	Rattus norvegicus	114-120
29599176-3	2018	Relevantly, Set1 methylates lysine residues in the kinetochore protein Dam1 while genetic studies of the S. pombe SET1 ortholog suggest the existence of non-H3K4 Set1 targets relevant to gene regulation.	Lysine	28-34	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	12-16
29628311-1	2018	The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3.	Lysine	157-163	embryonic ectoderm development	Mus musculus	74-77
12820959-0	2003	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	Lysine	83-89	succinate-CoA ligase ADP-forming subunit beta	Homo sapiens	13-19
29628311-1	2018	The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3.	Lysine	157-163	retinoblastoma binding protein 4, chromatin remodeling factor	Mus musculus	79-84
12820959-5	2003	The structure, together with the previous SCF(Skp2) structure, leads to the model of SCF catalyzing ubiquitination by increasing the effective concentration of the substrate lysine at the E2 active site.	Lysine	174-180	S-phase kinase associated protein 2	Homo sapiens	46-50
29892158-7	2018	Propanoylated lysine, a specific indicator of docosahexaenoic acid oxidation, was increased in neuronal differentiated human neuroblastoma SH-SY5Y cells overexpressing alpha-synuclein.	Lysine	14-20	synuclein alpha	Homo sapiens	168-183
12751628-5	2003	A model plasmid DNA, pSV-beta-Gal containing a reporter gene for beta-galactosidase was carried by the nanoemulsion/poly-L-lysine particles.	Lysine	116-129	galactosidase beta 1	Homo sapiens	65-83
29438996-6	2018	Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex.	Lysine	80-86	protein tyrosine kinase 2 beta	Homo sapiens	40-44
12586828-4	2003	Here we show that histone H3 Lys-9 methylation of the PWS-IC is reduced in mouse embryonic stem (ES) cells lacking the G9a histone H3 Lys-9/Lys-27 methyltransferase and that maintenance of CpG methylation of the PWS-IC in mouse ES cells requires the function of G9a.	Lysine	29-32	euchromatic histone lysine N-methyltransferase 2	Mus musculus	119-122
29438996-6	2018	Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex.	Lysine	80-86	protein tyrosine kinase 2 beta	Homo sapiens	105-109
29438996-6	2018	Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex.	Lysine	80-86	protein tyrosine kinase 2 beta	Homo sapiens	105-109
12586828-4	2003	Here we show that histone H3 Lys-9 methylation of the PWS-IC is reduced in mouse embryonic stem (ES) cells lacking the G9a histone H3 Lys-9/Lys-27 methyltransferase and that maintenance of CpG methylation of the PWS-IC in mouse ES cells requires the function of G9a.	Lysine	29-32	euchromatic histone lysine N-methyltransferase 2	Mus musculus	262-265
29511348-3	2018	BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription.	Lysine	38-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-88
12763785-5	2003	A critical position in the 5th TMS contains a lysine conserved in all known nonelectrogenic H,K-ATPases, and a serine in all known electrogenic Na,K-ATPase sequences.	Lysine	46-52	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	94-102
29498112-9	2018	Our results indicate that for both human and S. rosetta Cbl, ubiquitylation depends on proximity and accessibility, rather than being targeted toward specific lysine residues.	Lysine	159-165	Cbl proto-oncogene	Homo sapiens	56-59
12763785-7	2003	An electrogenic activity was recorded for the H,K-ATPase mutants in which the positively charged lysine had been replaced by neutral or negatively charged residues, while nonelectrogenic transport was observed with the S(782)R mutant of the Na,K-ATPase.	Lysine	97-103	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	48-56
29694893-3	2018	Here, we demonstrate an oncogenic role for the protein lysine methyltransferase SETDB2 in leukemia pathogenesis.	Lysine	55-61	SET domain bifurcated histone lysine methyltransferase 2	Homo sapiens	80-86
12640111-1	2003	Lysyl oxidase (LO), which catalyzes the oxidation of lysine residues, was previously shown to have anti-oncogenic activity on ras-transformed cells.	Lysine	53-59	lysyl oxidase	Mus musculus	0-13
29540553-7	2018	These findings suggest the functional importance of SIRT1 in regulating pathogenic tau acetylation and in suppressing the spread of tau pathology in vivoSIGNIFICANCE STATEMENT In neurodegenerative disorders with inclusions of microtubule-associated protein tau, aberrant lysine acetylation of tau plays critical roles in promoting tau accumulation and toxicity.	Lysine	271-277	sirtuin 1	Mus musculus	52-57
12640111-1	2003	Lysyl oxidase (LO), which catalyzes the oxidation of lysine residues, was previously shown to have anti-oncogenic activity on ras-transformed cells.	Lysine	53-59	lysyl oxidase	Mus musculus	15-17
12770769-9	2003	To rationalize our results we postulate that platelet alpha6FucT is folded through disulfide bonds that bring together donor/acceptor-binding- and cysteine- and lysine-rich, presumably acceptor substrate binding sites, thus creating a catalytic center of the enzyme.	Lysine	161-167	fucosyltransferase 8	Homo sapiens	54-64
29471495-6	2018	Using a methylation-specific antibody, we confirmed that TOP3B is methylated in cells and that mutation of R833 and R835 to lysine (K) significantly reduces TOP3B methylation.	Lysine	124-130	DNA topoisomerase III beta	Homo sapiens	157-162
12466273-7	2003	The effect of PF4 on binding ox-LDL was dependent on specific lysine residues in its C terminus.	Lysine	62-68	platelet factor 4	Homo sapiens	14-17
29540501-2	2018	Ash1 di-methylates lysine 36 in histone H3 (H3K36me2) but how this activity is controlled and at which genes it functions is not well understood.	Lysine	19-25	absent, small, or homeotic discs 1	Drosophila melanogaster	0-4
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	18-24	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	207-212
29523594-4	2018	HDAC3 facilitates lysine-63-chain polyubiquitination and phosphorylation of AKT, and this effect is mediated by AKT deacetylation at lysine 14 and 20 residues and HDAC3 interaction with the scaffold protein APPL1.	Lysine	133-139	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	207-212
12578380-5	2003	PTS1 variants that correspond to known functional targeting signals bind to the PEX5 fragment with a change in the standard binding free energy within 1.8 kcal mol(-1) of that corresponding to the peptide ending with -Ser-Lys-Leu-COO(-).	Lysine	222-225	peroxisomal biogenesis factor 5	Homo sapiens	80-84
29349500-4	2018	We hypothesized that exogenous H2S could switch cardiac energy metabolic substrate preference by lysine acetylation through promoting the expression of SIRT3 in cardiac tissue of db/db mice.	Lysine	97-103	sirtuin 3	Mus musculus	152-157
12578982-7	2003	Oligomerization, but not membrane binding, was disrupted by neutralization of two lysine residues (K326,327) within the C2B domain of syt.	Lysine	82-88	synaptotagmin 1	Homo sapiens	134-137
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	231-237	myogenin	Homo sapiens	124-132
12578986-4	2003	In this work, we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9) methylation and the underacetylation of histones.	Lysine	241-244	myogenin	Homo sapiens	124-132
29414790-10	2018	Mechanistically, KAT7 participates in VEGFR-2 transcription by mediating RNA polymerase II binding, H3 lysine 14, and H4 acetylation in its intragenic region.	Lysine	103-109	lysine acetyltransferase 7	Homo sapiens	17-21
12578986-6	2003	In addition, enrichment of histone H3 acetylation (Lys-9/14) and phosphorylation of Ser-10 can now be observed at the myogenin promoter.	Lysine	51-54	myogenin	Homo sapiens	118-126
29335521-7	2018	The proteasome-dependent degradation of CDK4 was accelerated by disrupting the interaction of PFKFB3 with CDK4 by mutating lysine (147) to alanine.	Lysine	123-129	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	94-100
12535660-2	2003	Mass spectrometry and immunoblot analysis revealed that TFAM was acetylated at a single lysine residue and that the level of acetylation did not change with age.	Lysine	88-94	transcription factor A, mitochondrial	Rattus norvegicus	56-60
29432156-8	2018	The extent of BubR1 ubiquitylation was markedly increased in recombinant MCC that contained a lysine-less mutant of Cdc20.	Lysine	94-100	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	14-19
29432156-9	2018	Mutation of lysine residues to arginines in the N-terminal region of BubR1 partially inhibited its ubiquitylation and slowed down the release of MCC from APC/C, provided that Cdc20 ubiquitylation was also blocked.	Lysine	12-18	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	69-74
29432173-2	2018	We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation mimetic lysine to glutamine substitution (K146Q).	Lysine	44-50	kinesin family member 11	Homo sapiens	58-61
29432173-2	2018	We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation mimetic lysine to glutamine substitution (K146Q).	Lysine	97-103	kinesin family member 11	Homo sapiens	58-61
12419806-3	2003	Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123.	Lysine	87-94	RELA proto-oncogene, NF-kB subunit	Homo sapiens	23-47
29288668-3	2018	In addition, Pex22p binding allows Pex4p to specifically produce lysine 48 linked ubiquitin chains in vitro through an unknown mechanism.	Lysine	65-71	E2 ubiquitin-protein ligase peroxin 4	Saccharomyces cerevisiae S288C	35-40
12419806-3	2003	Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123.	Lysine	87-94	E1A binding protein p300	Homo sapiens	70-74
29413895-3	2018	Here we show that histone 3 lysine 4 trimethylation (H3K4me3) modified by menin-MLL complex of IGF2 promoter contributes to promoter activity of IGF2.	Lysine	28-34	lysine methyltransferase 2A	Homo sapiens	80-83
29413895-3	2018	Here we show that histone 3 lysine 4 trimethylation (H3K4me3) modified by menin-MLL complex of IGF2 promoter contributes to promoter activity of IGF2.	Lysine	28-34	insulin like growth factor 2	Homo sapiens	95-99
29413895-3	2018	Here we show that histone 3 lysine 4 trimethylation (H3K4me3) modified by menin-MLL complex of IGF2 promoter contributes to promoter activity of IGF2.	Lysine	28-34	insulin like growth factor 2	Homo sapiens	145-149
12419806-3	2003	Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123.	Lysine	87-94	lysine acetyltransferase 2B	Homo sapiens	79-83
12525698-6	2003	The model can be extended into the cytoplasmic domain so that Lys-3 in PLN can be cross-linked with Lys-397 and Lys-400 in SERCA1a with little unwinding of the N-terminal helix of PLN.	Lysine	62-65	phospholamban	Homo sapiens	71-74
29052764-6	2018	Sequence analysis indicated that the coding region (CDS) of GhChlI is 1269 bp in length, with three predicted exons and one non-synonymous nucleotide mutation (G1082A) in the third exon of Gh_D10G0283, with an amino acid (AA) substitution of arginine (R) to lysine (K).	Lysine	258-264	magnesium-chelatase subunit ChlI, chloroplastic	Gossypium hirsutum	60-66
12525698-6	2003	The model can be extended into the cytoplasmic domain so that Lys-3 in PLN can be cross-linked with Lys-397 and Lys-400 in SERCA1a with little unwinding of the N-terminal helix of PLN.	Lysine	62-65	phospholamban	Homo sapiens	180-183
12525698-6	2003	The model can be extended into the cytoplasmic domain so that Lys-3 in PLN can be cross-linked with Lys-397 and Lys-400 in SERCA1a with little unwinding of the N-terminal helix of PLN.	Lysine	100-103	phospholamban	Homo sapiens	71-74
29336876-2	2018	The trimethylation of histone H3 lysine 9 (H3K9me3), a target of heterochromatin protein 1 (HP1), is a hallmark of heterochromatin formation.	Lysine	33-39	chromobox 5	Homo sapiens	65-90
12525698-6	2003	The model can be extended into the cytoplasmic domain so that Lys-3 in PLN can be cross-linked with Lys-397 and Lys-400 in SERCA1a with little unwinding of the N-terminal helix of PLN.	Lysine	100-103	phospholamban	Homo sapiens	71-74
29336876-2	2018	The trimethylation of histone H3 lysine 9 (H3K9me3), a target of heterochromatin protein 1 (HP1), is a hallmark of heterochromatin formation.	Lysine	33-39	chromobox 5	Homo sapiens	92-95
12527890-7	2003	The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation.	Lysine	62-65	jun proto-oncogene	Mus musculus	107-111
29404406-2	2018	Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins ASsociated with Set1) protein family that implements histone H3 lysine 4 monomethylation (H3K4me1) at enhancers, is essential for embryonic development and functions as a pancancer tumor suppressor.	Lysine	123-129	lysine methyltransferase 2D	Homo sapiens	0-4
12527890-7	2003	The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation.	Lysine	62-65	jun proto-oncogene	Mus musculus	184-188
29404406-2	2018	Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins ASsociated with Set1) protein family that implements histone H3 lysine 4 monomethylation (H3K4me1) at enhancers, is essential for embryonic development and functions as a pancancer tumor suppressor.	Lysine	123-129	lysine methyltransferase 2D	Homo sapiens	6-11
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Lysine	227-230	ectodysplasin A	Homo sapiens	48-51
28726069-3	2018	We recently showed that sirtuin 4 (SIRT4) removes glutaryl, 3-hydroxy-3-methylglutaryl, 3-methylglutaryl, and 3-methylglutaconyl modifications from lysine residues.	Lysine	148-154	sirtuin 4	Mus musculus	24-33
28726069-3	2018	We recently showed that sirtuin 4 (SIRT4) removes glutaryl, 3-hydroxy-3-methylglutaryl, 3-methylglutaryl, and 3-methylglutaconyl modifications from lysine residues.	Lysine	148-154	sirtuin 4	Mus musculus	35-40
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Lysine	239-242	ectodysplasin A	Homo sapiens	48-51
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Lysine	239-242	ectodysplasin A	Homo sapiens	48-51
12456318-2	2003	When plasminogen is bound to cell-surface proteins with C-terminal lysines via its lysine binding sites, its activation to plasmin is accelerated, and cell-bound plasmin is protected from inactivation by natural inhibitors.	Lysine	67-74	plasminogen	Homo sapiens	5-12
29153549-6	2017	In this 2-stage process, emetine prodrug intermediates are coupled to PSA peptide substrate (Ac-His-Ser-Ser-Lys-Leu-Gln) to obtain the full prodrug.	Lysine	108-111	kallikrein related peptidase 3	Homo sapiens	70-73
12456318-2	2003	When plasminogen is bound to cell-surface proteins with C-terminal lysines via its lysine binding sites, its activation to plasmin is accelerated, and cell-bound plasmin is protected from inactivation by natural inhibitors.	Lysine	67-74	plasminogen	Homo sapiens	123-130
12456318-2	2003	When plasminogen is bound to cell-surface proteins with C-terminal lysines via its lysine binding sites, its activation to plasmin is accelerated, and cell-bound plasmin is protected from inactivation by natural inhibitors.	Lysine	67-73	plasminogen	Homo sapiens	5-12
12456318-7	2003	New receptors may be generated by trypsin-like proteases, including plasmin, which create new C-terminal lysines; other enzymes may expose existing membrane proteins by altering the cell surface; or receptor function may be lost by removal of C-terminal lysines.	Lysine	105-112	plasminogen	Homo sapiens	68-75
29239724-5	2017	We further demonstrate that SIRT2-mediated lysine defatty-acylation promotes endomembrane localization of K-Ras4a, enhances its interaction with A-Raf, and thus promotes cellular transformation.	Lysine	43-49	sirtuin 2	Homo sapiens	28-33
12456318-7	2003	New receptors may be generated by trypsin-like proteases, including plasmin, which create new C-terminal lysines; other enzymes may expose existing membrane proteins by altering the cell surface; or receptor function may be lost by removal of C-terminal lysines.	Lysine	254-261	plasminogen	Homo sapiens	68-75
29239724-5	2017	We further demonstrate that SIRT2-mediated lysine defatty-acylation promotes endomembrane localization of K-Ras4a, enhances its interaction with A-Raf, and thus promotes cellular transformation.	Lysine	43-49	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	145-150
12461785-3	2003	The oxidation of lysine residues in bFGF by LO resulted in the covalent crosslinking of bFGF monomers to form dimers and higher order oligomers and dramatically altered its biological properties.	Lysine	17-23	fibroblast growth factor 2	Mus musculus	36-40
29060933-2	2017	NDRG2 has been shown to be SUMOylated on the lysine 333 residue, which promoted its ubiquitination and sequentially degradation by the SUMO-targeted ubiquitin E3 ligase RNF4.	Lysine	45-51	NDRG family member 2	Homo sapiens	0-5
29060933-2	2017	NDRG2 has been shown to be SUMOylated on the lysine 333 residue, which promoted its ubiquitination and sequentially degradation by the SUMO-targeted ubiquitin E3 ligase RNF4.	Lysine	45-51	ring finger protein 4	Homo sapiens	169-173
2554961-8	1989	The involvement of lysines-95 and -97 is especially significant, since they are located in an extra loop comprising residues 89-98 that is not present in eukaryotic cytochrome c.	Lysine	19-26	cytochrome c, somatic	Equus caballus	165-177
2554961-9	1989	The reactions of horse cytochrome c derivatives modified at single lysine amino groups with trifluoroacetyl or [(trifluoromethyl)phenyl]carbamoyl were also studied.	Lysine	67-73	cytochrome c, somatic	Equus caballus	23-35
28806398-0	2017	Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism.	Lysine	0-6	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-28
12461785-3	2003	The oxidation of lysine residues in bFGF by LO resulted in the covalent crosslinking of bFGF monomers to form dimers and higher order oligomers and dramatically altered its biological properties.	Lysine	17-23	fibroblast growth factor 2	Mus musculus	88-92
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Lysine	165-171	E1A binding protein p300	Homo sapiens	8-12
28806398-5	2017	Here we provide evidence for an SCFFbxw7-independent regulatory mechanism centred on the highly conserved lysine-52 (K52) within MYC Box I.	Lysine	106-112	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	129-132
28841214-0	2017	Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.	Lysine	35-41	PHD finger protein 20 like 1	Homo sapiens	21-28
2554961-10	1989	The derivatives modified at lysines-22, -55, -88, and -99 far removed from the heme crevice had nearly the same half-times for the fast phase as native cytochrome c, 6 microseconds.	Lysine	28-35	cytochrome c, somatic	Equus caballus	152-164
12486002-4	2002	It has recently been shown that acetylation at a single lysine, residue 50, regulated the association of Tat with PCAF.	Lysine	56-62	tyrosine aminotransferase	Homo sapiens	105-108
2573291-8	1989	On the other hand, the impurity in the [Bpa-8]dynorphin A (1-17) preparation, where the removal of the formyl group from Trp-14 was carried out using piperidine, was shown to result from migration of the formyl group to Lys-11 or Lys-13.	Lysine	220-223	thioredoxin domain containing 17	Homo sapiens	121-127
2573291-8	1989	On the other hand, the impurity in the [Bpa-8]dynorphin A (1-17) preparation, where the removal of the formyl group from Trp-14 was carried out using piperidine, was shown to result from migration of the formyl group to Lys-11 or Lys-13.	Lysine	230-233	thioredoxin domain containing 17	Homo sapiens	121-127
27282883-1	2017	In pediatric acute leukemias, reciprocal chromosomal translocations frequently cause gene fusions involving the lysine (K)-specific methyltransferase 2A gene (KMT2A, also known as MLL).	Lysine	112-118	lysine methyltransferase 2A	Homo sapiens	159-164
27282883-1	2017	In pediatric acute leukemias, reciprocal chromosomal translocations frequently cause gene fusions involving the lysine (K)-specific methyltransferase 2A gene (KMT2A, also known as MLL).	Lysine	112-118	lysine methyltransferase 2A	Homo sapiens	180-183
12486002-4	2002	It has recently been shown that acetylation at a single lysine, residue 50, regulated the association of Tat with PCAF.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	114-118
12486002-8	2002	Thus, differential lysine acetylation of Tat coordinates the interactions with its co-activators, cyclin T1 and PCAF.	Lysine	19-25	tyrosine aminotransferase	Homo sapiens	41-44
2546631-1	1989	Human 125I-plasminogen bound readily to rat hepatocytes in primary culture at 4 degrees C and at 37 degrees C. Binding was inhibited by lysine and reversed by lysine, epsilon-aminocaproic acid, or nonradiolabeled plasminogen.	Lysine	136-142	plasminogen	Rattus norvegicus	11-22
12486002-8	2002	Thus, differential lysine acetylation of Tat coordinates the interactions with its co-activators, cyclin T1 and PCAF.	Lysine	19-25	lysine acetyltransferase 2B	Homo sapiens	112-116
2546631-1	1989	Human 125I-plasminogen bound readily to rat hepatocytes in primary culture at 4 degrees C and at 37 degrees C. Binding was inhibited by lysine and reversed by lysine, epsilon-aminocaproic acid, or nonradiolabeled plasminogen.	Lysine	159-165	plasminogen	Rattus norvegicus	11-22
12456660-2	2002	We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 310 for modification.	Lysine	136-143	E1A binding protein p300	Homo sapiens	28-32
29083415-3	2017	To address this limitation, we generated LCK*, in which a key active-site lysine is replaced by a photocaged equivalent, using genetic code expansion.	Lysine	74-80	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-45
12456660-2	2002	We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and 310 for modification.	Lysine	136-143	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-112
12456660-3	2002	Analysis of the functional properties of hypoacetylated RelA mutants containing lysine-to-arginine substitutions at these sites and of wild-type RelA co-expressed in the presence of a dominantly interfering mutant of p300 reveals that acetylation at lysine 221 in RelA enhances DNA binding and impairs assembly with IkappaBalpha.	Lysine	250-256	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-60
28947430-13	2017	SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of LKB1-AMPK signaling.	Lysine	43-49	sirtuin 2	Mus musculus	0-5
2804442-4	1989	The molecular weight, 2857.4 and 2858.4, indicated the amino acid substitutions of asparagine and aspartic acid, respectively, for lysine at position 82 of beta globin chain.	Lysine	131-137	hemoglobin subunit beta	Homo sapiens	156-173
12456660-3	2002	Analysis of the functional properties of hypoacetylated RelA mutants containing lysine-to-arginine substitutions at these sites and of wild-type RelA co-expressed in the presence of a dominantly interfering mutant of p300 reveals that acetylation at lysine 221 in RelA enhances DNA binding and impairs assembly with IkappaBalpha.	Lysine	250-256	E1A binding protein p300	Homo sapiens	217-221
12456660-4	2002	Conversely, acetylation of lysine 310 is required for full transcriptional activity of RelA in the absence of effects on DNA binding and IkappaBalpha assembly.	Lysine	27-33	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-91
12413830-7	2002	A superposition of the calculated structures of hU-II and 3 clearly shows that three out of four key residues (i.e., Phe(6), Lys(8) and Tyr(9)) maintain the same side- chain orientation, while the fourth one, Trp(7), cannot be superimposed.	Lysine	125-128	ribosomal protein S6 kinase A3	Homo sapiens	48-59
2527365-4	1989	The mosxe gene is transforming when introduced into murine NIH 3T3 cells, and transformation is abrogated by a lysine-to-arginine mutation in the canonical ATP-binding site.	Lysine	111-117	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	4-9
2751482-5	1989	When LDL was derivatized with lower concentrations of HNE, concentration-dependent increases were observed in the covalent binding of HNE to apolipoprotein B (apo B), the blockage of the epsilon-amino groups on lysine residues of apo B, and the relative electrophoretic mobility of LDL.	Lysine	211-217	apolipoprotein B	Mus musculus	141-157
29131831-8	2017	CPD cleaved C-terminal Lys or Arg from a subset of the peptides.	Lysine	23-26	carboxypeptidase D	Homo sapiens	0-3
28849174-0	2017	TSA increases C/EBP-alpha expression by increasing its lysine acetylation in hepatic stellate cells.	Lysine	55-61	CCAAT/enhancer binding protein alpha	Rattus norvegicus	14-25
28849174-7	2017	Co-immunoprecipitation analysis was used to examine the lysine acetylation of C/EBP-alpha.	Lysine	56-62	CCAAT/enhancer binding protein alpha	Rattus norvegicus	78-89
28849174-11	2017	Therefore, the results of the present study suggested that TSA may increase C/EBP-alpha expression by increasing its lysine acetylation in HSCs.	Lysine	117-123	CCAAT/enhancer binding protein alpha	Rattus norvegicus	76-87
12542170-19	2002	In conclusion, these results provide evidence that protein (lysine) restriction throughout lactation alters circulating concentrations of somatotropic hormones and insulin at the end of lactation and has a negative impact on postweaning ovulation rate.	Lysine	60-66	insulin	Sus scrofa	164-171
29107294-6	2017	RESULTS: Amino acids such as Arg, Lys, and Ala evoke Ca2+ signals in tanycytes and evoke the release of ATP via pannexin 1 and CalHM1, which amplifies the signal via a P2 receptor dependent mechanism.	Lysine	34-37	calcium homeostasis modulator 1	Mus musculus	127-133
12417736-2	2002	The type B histone acetyltransferase Hat1p and specific lysine residues in the histone H3 NH(2)-terminal tail (primarily lysine 14) are redundantly required for telomeric silencing.	Lysine	121-127	histone acetyltransferase 1	Homo sapiens	37-42
29268844-6	2017	Chromatin immunoprecipitation (ChIP) was done to evaluate the effect of KAT6B on the recruitment of acetylation of histone 3 lysine 23 (H3K23ac) within IL-6 promoter region.	Lysine	125-131	K(lysine) acetyltransferase 6B	Mus musculus	72-77
2473902-1	1989	The epitopes (antigenic determinants) recognized by four different monoclonal antibodies on horse cytochrome c have been partially characterized by differential acetylation of lysine residues of free and antibody-bound cytochrome c.	Lysine	176-182	cytochrome c, somatic	Equus caballus	98-110
2473902-3	1989	Out of the 19 lysine residues of cytochrome c only very few were less reactive in the antigen-antibody complex, i.e. presumably located at the epitope for the antibody under study.	Lysine	14-20	cytochrome c, somatic	Equus caballus	33-45
12435631-5	2002	This complex, which we termed Polycomb repressive complex (PRC) 2, possesses HMT activity with specificity for Lys 9 (K9) and Lys 27 (K27) of histone H3.	Lysine	111-114	PR/SET domain 9	Homo sapiens	77-80
2538756-4	1989	The longer C-terminal extension protein (CEP80) is 30% lysine and arginine and, when denatured, behaves like a small cationic protein.	Lysine	55-61	ribosomal protein S27a	Homo sapiens	41-46
28892616-4	2017	Upon identifying a lead hit from this screen KEA1-97, we used activity-based protein profiling (ABPP)-based chemoproteomic platforms to identify that this compound targets lysine 72 of thioredoxin-a site previously shown to be important in protein interactions with caspase 3 to inhibit caspase 3 activity and suppress apoptosis.	Lysine	172-178	thioredoxin	Homo sapiens	185-196
28965816-5	2017	Moreover, Tetherin recruits E3 ubiquitin ligase MARCH8 to catalyze K27-linked ubiquitin chains on MAVS at lysine 7, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	106-112	mitochondrial antiviral signaling protein	Homo sapiens	98-102
12435631-5	2002	This complex, which we termed Polycomb repressive complex (PRC) 2, possesses HMT activity with specificity for Lys 9 (K9) and Lys 27 (K27) of histone H3.	Lysine	126-129	PR/SET domain 9	Homo sapiens	77-80
12419248-2	2002	We found that only a small subset of lysines in histones H4 and H3 are acetylated in vivo by the GCN5 acetyltransferase during activation of the IFN-beta gene.	Lysine	37-44	interferon beta 1	Homo sapiens	145-153
29163825-1	2017	K (lysine) acetyltransferase 8 (KAT8), an acetyltransferase that specifically catalyzes histone H4 lysine 16 acetylation, is critical for key biological processes including cell proliferation and maintenance of genome stability.	Lysine	3-9	lysine acetyltransferase 8	Sus scrofa	32-36
12519628-2	2002	The plasmid DNA that contained the Escherichia coli beta-galactosidase reporter gene was condensed using poly-l-lysine of molecular mass 20,700 (PLK99) to form a polyplex which was interacted with several anionic liposome formulations to form lipopolyplexes.	Lysine	105-118	galactosidase beta 1	Homo sapiens	52-70
29098080-4	2017	Here we report the first PTM with functional characterization on YY2, namely lysine 247 monomethylation (K247me1), which was found to be dynamically regulated by SET7/9 and LSD1 both in vitro and in cultured cells.	Lysine	77-83	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	162-168
2716051-4	1989	Electron microscopic examinations of antibody-myosin complexes revealed that the J1 and J2 junctions are located 15 nm and 16 nm from the head-rod junction, respectively, while the reactive lysine residue region is 13 nm from the junction.	Lysine	190-196	myosin heavy chain 14	Homo sapiens	46-52
2492530-9	1989	Thus, binding of heparin to human antithrombin diminished S-DABITC modification at Lys-107, Lys-125, and Lys-136, but at the same time enhanced S-DABITC modification at Lys-236.	Lysine	92-95	serpin family C member 1	Homo sapiens	34-46
2492530-12	1989	At a heparin/antithrombin molar ratio of 1, the extent of shielding of Lys-125 and Lys-136 and the unmasking of Lys-236 were 25-33%.	Lysine	71-74	serpin family C member 1	Homo sapiens	13-25
2492530-12	1989	At a heparin/antithrombin molar ratio of 1, the extent of shielding of Lys-125 and Lys-136 and the unmasking of Lys-236 were 25-33%.	Lysine	83-86	serpin family C member 1	Homo sapiens	13-25
2492530-12	1989	At a heparin/antithrombin molar ratio of 1, the extent of shielding of Lys-125 and Lys-136 and the unmasking of Lys-236 were 25-33%.	Lysine	83-86	serpin family C member 1	Homo sapiens	13-25
12356296-0	2002	Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.	Lysine	20-26	potassium voltage-gated channel subfamily A member 3	Homo sapiens	142-147
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	17-20	serpin family C member 1	Homo sapiens	101-113
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	17-20	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	17-20	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	101-113
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	101-113
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
28872461-6	2017	Mechanistic studies revealed that trihydroxyphenolics induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI kinase.	Lysine	98-104	transforming growth factor beta receptor 1	Homo sapiens	270-277
27615678-10	2017	The presence of a potassium-binding pocket within the active site of mammalian TyrRS compensates the absence of the second lysine in the KMSKS motif.	Lysine	123-129	tyrosyl-tRNA synthetase 1	Homo sapiens	79-84
12419227-4	2002	Removal of SUMO-1 from Sp3 by mutation of the SUMO acceptor lysines or expression of the SUMO-1 protease SuPr-1 converted Sp3 to a strong activator with a diffuse nuclear localization.	Lysine	60-67	small ubiquitin like modifier 1	Homo sapiens	11-17
28966167-5	2017	Preventing ubiquitylation of Rad23 by mutation of lysine residues within the UbL domain, Rad23UbLK0, does not affect the non-proteolytic role of Rad23 in DNA repair but causes an increase in ubiquitylated cargo bound to the UBA2 domain of Rad23, recapitulating the stabilization of Rad23-dependent substrates observed upon overexpression of Ubp12.	Lysine	50-56	Rad23p	Saccharomyces cerevisiae S288C	29-34
28966167-5	2017	Preventing ubiquitylation of Rad23 by mutation of lysine residues within the UbL domain, Rad23UbLK0, does not affect the non-proteolytic role of Rad23 in DNA repair but causes an increase in ubiquitylated cargo bound to the UBA2 domain of Rad23, recapitulating the stabilization of Rad23-dependent substrates observed upon overexpression of Ubp12.	Lysine	50-56	Rad23p	Saccharomyces cerevisiae S288C	89-94
28966167-5	2017	Preventing ubiquitylation of Rad23 by mutation of lysine residues within the UbL domain, Rad23UbLK0, does not affect the non-proteolytic role of Rad23 in DNA repair but causes an increase in ubiquitylated cargo bound to the UBA2 domain of Rad23, recapitulating the stabilization of Rad23-dependent substrates observed upon overexpression of Ubp12.	Lysine	50-56	Rad23p	Saccharomyces cerevisiae S288C	89-94
28966167-5	2017	Preventing ubiquitylation of Rad23 by mutation of lysine residues within the UbL domain, Rad23UbLK0, does not affect the non-proteolytic role of Rad23 in DNA repair but causes an increase in ubiquitylated cargo bound to the UBA2 domain of Rad23, recapitulating the stabilization of Rad23-dependent substrates observed upon overexpression of Ubp12.	Lysine	50-56	Rad23p	Saccharomyces cerevisiae S288C	89-94
28966167-5	2017	Preventing ubiquitylation of Rad23 by mutation of lysine residues within the UbL domain, Rad23UbLK0, does not affect the non-proteolytic role of Rad23 in DNA repair but causes an increase in ubiquitylated cargo bound to the UBA2 domain of Rad23, recapitulating the stabilization of Rad23-dependent substrates observed upon overexpression of Ubp12.	Lysine	50-56	putative ubiquitin-specific protease UBP12	Saccharomyces cerevisiae S288C	341-346
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	101-113
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
2492530-14	1989	We conclude that Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of human antithrombin and that binding of heparin to antithrombin causes a conformational change of antithrombin that leads to the exposure of Lys-236 for S-DABITC modification.	Lysine	26-29	serpin family C member 1	Homo sapiens	145-157
12070147-4	2002	When the lysine residue at the putative ubiquitination site of the N-degron was substituted with arginine, both the protein level and half-life of mutant Gts1p increased.	Lysine	9-15	Gts1p	Saccharomyces cerevisiae S288C	154-159
2475147-3	1989	We identified the NF-H multi-phosphorylation repeat domain, i.e. repeats of Lys-Ser-Pro-X (where X is a small uncharged amino acid and Ser acts as a phosphate acceptor), as the determinant recognized by 15/16 MAbs that detected NFTs in sections of AD hippocampus, and 11 of the same 16 MAbs recognised NF-M multi-phosphorylation repeats.	Lysine	76-79	neurofilament heavy chain	Homo sapiens	18-22
28666590-4	2017	For example, TLS is mediated by mono-ubiquitination of PCNA at lysine 164, for which RAD6-RAD18 is the primary E2-E3 complex.	Lysine	63-69	proliferating cell nuclear antigen	Homo sapiens	55-59
28666590-6	2017	The template switching pathway is promoted by K63-linked poly-ubiquitination of PCNA at lysine 164.	Lysine	88-94	proliferating cell nuclear antigen	Homo sapiens	80-84
28943877-8	2017	Acetylation of p65 by p300 likely underlies these events, as inhibition of the p300-beta-catenin interaction diminished levels of acetylated p65 at lysine 310, thereby reducing p65 transcriptional activity.	Lysine	148-154	catenin beta 1	Homo sapiens	84-96
12226657-4	2002	PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9.	Lysine	63-69	ubiquitin conjugating enzyme E2 I	Homo sapiens	181-185
28886131-8	2017	We observed increased IRS2 lysine acetylation as a consequence of histone deacetylase inhibition, a modification that was coupled with a decrease in IRS2 tyrosine phosphorylation.	Lysine	27-33	insulin receptor substrate 2	Mus musculus	22-26
2739643-2	1989	Point mutations alpha 58 His----Tyr (Hb M Boston), beta 6 Glu--lys (Hb C) and beta 26 Glu----Lys (Hb E) have been identified in abnormal hemoglobins by means of tryptic hydrolysis of their alpha- and beta-chains followed by mass-spectrometry coupled with direct extraction of ions from solution.	Lysine	63-66	keratin 88, pseudogene	Homo sapiens	68-72
28877467-3	2017	Here, using a combination of live-cell imaging and functional genomics, we discover that the vertebrate SET1 complex is targeted to actively transcribed gene promoters through CFP1, which engages in a form of multivalent chromatin reading that involves recognition of non-methylated DNA and histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	302-308	CXXC finger protein 1	Homo sapiens	176-180
12200128-7	2002	Mutation of lysine 1086 of SALL1 to arginine abrogates SALL1 sumoylation, suggesting the presence of a polymeric SUMO-1 chain in the wild type state.	Lysine	12-18	small ubiquitin like modifier 1	Homo sapiens	113-119
28545977-2	2017	GCDH deficiency leads to disruption of l-lysine degradation with characteristic accumulation of glutarylcarnitine and neurotoxic glutaric acid (GA), glutaryl-CoA, 3-hydroxyglutaric acid (3-OHGA).	Lysine	39-47	glutaryl-Coenzyme A dehydrogenase	Mus musculus	0-4
3142523-1	1988	The reaction of lysine with dithioesters was applied to horseradish peroxidase donor: hydrogen-peroxide oxidoreductase, EC 1.11.1.7) using carboxymethyl dithiotridecanoate: three to four lysine residues were modified.	Lysine	16-22	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	120-124
3142523-1	1988	The reaction of lysine with dithioesters was applied to horseradish peroxidase donor: hydrogen-peroxide oxidoreductase, EC 1.11.1.7) using carboxymethyl dithiotridecanoate: three to four lysine residues were modified.	Lysine	187-193	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	120-124
12142001-2	2002	Two different classes of histone methyltransferase (HMT) have been described, which target either lysine or arginine residues in the histone N-terminal tails.	Lysine	98-104	PR/SET domain 9	Homo sapiens	25-50
3143485-13	1988	The five genes, rpl23 (101 codons), rpl2 (278 codons), rps19 (95 codons), rpl22 (114 codons) and rps3 (220 codons) encode lysine-rich polypeptides with predicted molecular weights of 12,152, 31,029, 10,880, 12,819, and 25,238, respectively.	Lysine	122-128	rpl22	Euglena gracilis	74-79
3143485-13	1988	The five genes, rpl23 (101 codons), rpl2 (278 codons), rps19 (95 codons), rpl22 (114 codons) and rps3 (220 codons) encode lysine-rich polypeptides with predicted molecular weights of 12,152, 31,029, 10,880, 12,819, and 25,238, respectively.	Lysine	122-128	30S ribosomal protein S3	Euglena gracilis	97-101
28911000-6	2017	Dicer knockdown increased SIRT7 binding and decreased the level of H3K18Ac (acetylated lysine 18 of histone H3) at DSB sites, thereby repressing the recruitment of NHEJ factors to DSB sites and inhibiting NHEJ.	Lysine	87-93	dicer 1, ribonuclease III	Homo sapiens	0-5
12142001-2	2002	Two different classes of histone methyltransferase (HMT) have been described, which target either lysine or arginine residues in the histone N-terminal tails.	Lysine	98-104	PR/SET domain 9	Homo sapiens	52-55
28760777-6	2017	An in vitro SUMOylation assay and immunoprecipitation revealed that when SENP1 associated with N1ICD (NOTCH1 intracellular domain), it functions as a deSUMOylase of N1ICD SUMOylation on conserved lysines.	Lysine	196-203	notch 1	Mus musculus	102-108
12142001-3	2002	A flurry of recent papers now describe a third class of HMT that affects chromatin silencing indirectly, not by methylation of histone tails, but instead by targeting a conserved lysine residue in the core domain of the nucleosome.	Lysine	179-185	PR/SET domain 9	Homo sapiens	56-59
12107279-11	2002	We propose that the stabilization of intermediate ODC x I(-) is achieved by movement of the carbanion toward the external cation Lys-93 on decarboxylation and organization of the 203-218 loop.	Lysine	129-132	ornithine decarboxylase 1	Homo sapiens	50-53
28687409-8	2017	Furthermore, the deacetylase effect of Sirt3 enhanced the MnSOD activity by deacetylation at the lysine 68 residue and therapeutic effect of UCB-MSCs on skin-wound healing was increased by EphB2 activation.	Lysine	97-103	EPH receptor B2	Homo sapiens	189-194
3214553-7	1988	The chromatographic behaviour of these N-terminal peptides on a reversed phase C18 column is also identical, thus suggesting also for the rabbit Cu-Zn superoxide dismutase the N-terminal sequence Ac-Ala-Thr-Lys.	Lysine	207-210	superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	145-171
12095635-5	2002	These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition.	Lysine	75-78	serpin family D member 1	Homo sapiens	69-73
2836414-6	1988	These results support a model in which the lysines surrounding the heme crevice of cytochrome c interact with carboxylates on subunit II of one monomer of the cytochrome c oxidase dimer and the back of the molecule is close to subunit III on the other monomer.	Lysine	43-50	cytochrome c, somatic	Equus caballus	83-95
2836414-6	1988	These results support a model in which the lysines surrounding the heme crevice of cytochrome c interact with carboxylates on subunit II of one monomer of the cytochrome c oxidase dimer and the back of the molecule is close to subunit III on the other monomer.	Lysine	43-50	cytochrome c, somatic	Equus caballus	159-171
28970783-1	2017	Histone demethylase UTX mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish a mechanistic switch to activate large sets of genes.	Lysine	84-90	lysine (K)-specific demethylase 6A	Mus musculus	0-23
12298195-4	2002	interacts with lysine to form a thermodynamically stable complex with proton transfer and formation of the HO2.	Lysine	15-21	heme oxygenase 2	Homo sapiens	107-110
28819146-4	2017	Here, we show that the microtubule-binding repeats of Tau, which are lysine-rich, undergo liquid-liquid phase separation in solution.	Lysine	69-75	microtubule associated protein tau	Homo sapiens	54-57
3131329-11	1988	140, 1-14), the results suggest that Lys-111, located in the smaller of the two lobes of hexokinase, moves into the active site upon formation of the ternary complex.	Lysine	37-40	hexokinase	Saccharomyces cerevisiae S288C	89-99
12135563-1	2002	Enterokinase (EC 3.4.21.9) is a serine proteinase in the duodenum that exhibits specificity for the sequence (Asp)(4)-Lys.	Lysine	118-121	transmembrane serine protease 15	Bos taurus	0-12
3394172-5	1988	The results obtained indicate that lysine binding sites located at plasminogen K 1-3 and K 4 fragments correspond to different fibrinogen molecule centres.	Lysine	35-41	keratin 13	Homo sapiens	79-84
28727448-5	2017	This lysine derivative has a bio-orthogonally reactive group at the end of a long side chain, enabling identification of multiple new positions in Fab-constant domains, allowing chemical conjugation with high efficiency.	Lysine	5-11	FA complementation group B	Homo sapiens	147-150
28623232-8	2017	Mono-ubiquitination levels of a K275A mutant were lower, and its association with PDZRN3 was reduced compared with wild-type (WT) CLDN16 and a K261A mutant, indicating that Lys-275 is the major ubiquitination site.	Lysine	173-176	PDZ domain containing RING finger 3	Rattus norvegicus	82-88
2826157-2	1987	For investigations of the functional roles of the lysine residues of cytochrome c, analogues in which these residues are modified without charge loss are highly desirable.	Lysine	50-56	cytochrome c, somatic	Equus caballus	69-81
28623232-8	2017	Mono-ubiquitination levels of a K275A mutant were lower, and its association with PDZRN3 was reduced compared with wild-type (WT) CLDN16 and a K261A mutant, indicating that Lys-275 is the major ubiquitination site.	Lysine	173-176	claudin 16	Rattus norvegicus	130-136
12135568-0	2002	An Arg/Lys--&gt;Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis.	Lysine	7-10	myelin basic protein	Mus musculus	49-69
3121595-7	1987	259, 935-938) have shown that selective chemical modification of a limited number of lysine residues in antithrombin III causes drastic loss of its heparin cofactor activity.	Lysine	85-91	serpin family C member 1	Homo sapiens	104-120
3121595-8	1987	We have performed chemical modification of antithrombin III with trinitrobenzene sulfonic acid in order to determine the location of these lysine residues.	Lysine	139-145	serpin family C member 1	Homo sapiens	43-59
28692326-0	2017	Deletion of eIF2beta lysine stretches creates a dominant negative that affects the translation and proliferation in human cell line: A tool for arresting the cell growth.	Lysine	21-27	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	12-20
12069614-5	2002	Both MS methods detected six CcO subunits with an increased mass of 156 Da after reaction with HNE (subunits II, IV, Vb, VIIa, VIIc, and VIII); this result indicates a single Michael-type reaction site on either a lysine or histidine residue within each subunit.	Lysine	214-220	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	29-32
28572241-3	2017	Short-term activation (&lt;30 minutes) of protein kinase C (PKC) promotes the attachment of a lysine 48-linked polyubiquitin chain to hOAT1, a process catalyzed by ubiquitin ligase neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2).	Lysine	94-100	solute carrier family 22 member 6	Homo sapiens	134-139
28572241-8	2017	These results suggest that PKC-regulated and Nedd4-2-catalyzed attachment of a lysine 48-linked polyubiquitin chain to hOAT1 is important for hOAT1 stability.	Lysine	79-85	solute carrier family 22 member 6	Homo sapiens	119-124
12050216-8	2002	The aldosterone response of cultured ZG cells to VIP or PACAP was unaffected by the PAC(1) receptor antagonist PACAP-(6-38) (PAC(1)-A), but was significantly decreased by the VPAC(1) receptor antagonist [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP-(3-7),GH-releasing factor-(8-27)-NH(2) (VPAC(1)-A).	Lysine	223-226	adenylate cyclase activating polypeptide 1	Homo sapiens	56-61
28572241-8	2017	These results suggest that PKC-regulated and Nedd4-2-catalyzed attachment of a lysine 48-linked polyubiquitin chain to hOAT1 is important for hOAT1 stability.	Lysine	79-85	solute carrier family 22 member 6	Homo sapiens	142-147
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Lysine	140-146	complement C6	Bos taurus	102-105
12022872-6	2002	TAFI was also cleaved at Arg(302), Lys(327), and Arg(330), resulting in a approximately 44.3-kDa fragment and several smaller fragments.	Lysine	35-38	carboxypeptidase B2	Homo sapiens	0-4
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Lysine	140-146	complement C6	Bos taurus	187-190
28108335-6	2017	RESULTS: We show that tryptase truncates nucleosomal histone 3 and histone 2B (H2B) and that its absence results in accumulation of the epigenetic mark, lysine 5-acetylated H2B.	Lysine	153-159	tryptase alpha/beta 1	Mus musculus	22-30
28486049-7	2017	Mechanistic studies demonstrate that hypoxic insult enhances the interaction of FUNDC1 with MARCH5, which ubiquitinates FUNDC1 at lysine 119 for subsequent degradation.	Lysine	130-136	membrane associated ring-CH-type finger 5	Homo sapiens	92-98
11861638-10	2002	In vitro experiments using furin and purified EC-SOD suggest that furin proteolytically cleaves EC-SOD in the middle of the polybasic region and then requires an additional carboxypeptidase to remove the remaining lysines and arginines.	Lysine	214-221	furin, paired basic amino acid cleaving enzyme	Homo sapiens	27-32
28662362-5	2017	The acetylation status of lysine 68 of superoxide dismutase (SOD2K68) is dependent on Sirt3 in oocytes.	Lysine	26-32	sirtuin 3	Mus musculus	86-91
3038904-9	1987	The reaction rates of horse heart cytochrome c derivatives modified at single lysine amino groups with trifluoroacetyl or trifluoromethylphenylcarbamoyl were also measured.	Lysine	78-84	cytochrome c, somatic	Equus caballus	34-46
3113947-4	1987	Evidence was obtained that arginine and lysine were released from the C terminus of the pentapeptide before amidation took place since the rate of formation of dipeptide amide was reduced at pH values that were compatible with amidation but unfavourable to the action of carboxypeptidase H.	Lysine	40-46	carboxypeptidase E	Homo sapiens	271-289
11861638-10	2002	In vitro experiments using furin and purified EC-SOD suggest that furin proteolytically cleaves EC-SOD in the middle of the polybasic region and then requires an additional carboxypeptidase to remove the remaining lysines and arginines.	Lysine	214-221	furin, paired basic amino acid cleaving enzyme	Homo sapiens	66-71
11982427-2	2002	Three MRPs, Xyl-Lys MRP, Glu-Lys MRP, and Fru-Lys MRP, were prepared by heating lysine with xylose, glucose, and fructose, respectively, at pH 9.0 and 100 degrees C for 3 h and called undialyzed MRPs.	Lysine	80-86	zinc finger and BTB domain containing 22	Homo sapiens	42-45
3297348-5	1987	This receptor appears novel, lacking significant homology with other proteins; however, TF contains the uncommon tryptophan-lysine-serine (WKS) sequence repeated three times, a sequence we find in some serine protease-binding proteins and suggest may represent a functional sequence motif.	Lysine	124-130	coagulation factor III, tissue factor	Homo sapiens	88-90
28473327-12	2017	In line herewith, administration of LY-294002 reduced the expression of autophagy, EMT, and airway remodeling markers in FSTL1-challenged WT mice.	Lysine	36-38	follistatin-like 1	Mus musculus	121-126
11844798-2	2002	Sequence analysis and x-ray crystallographic investigations showed that the cross-linked residues were glutamic acid 82 of profilin and lysine 113 of actin.	Lysine	136-142	actin epsilon 1	Bos taurus	150-155
28388007-6	2017	Consistently, lysine-MCC-DM1, the active T-DM1 metabolite that inhibits microtubule polymerization, accumulated much less in N87-KR cells than in N87 cells.	Lysine	14-20	immunoglobulin heavy diversity 1-7	Homo sapiens	25-28
28388007-6	2017	Consistently, lysine-MCC-DM1, the active T-DM1 metabolite that inhibits microtubule polymerization, accumulated much less in N87-KR cells than in N87 cells.	Lysine	14-20	immunoglobulin heavy diversity 1-7	Homo sapiens	43-46
3109105-2	1987	The zootechnical parameters and protein value were optimum at the content of 5.22 g Lys per 16 g nitrogen in the feed, the activity of liver xanthine dehydrogenase was maximum.	Lysine	84-87	xanthine dehydrogenase/oxidase	Coturnix japonica	141-163
2433768-2	1987	By comparing the degree of acetylation of 18 lysine and 7 threonine residues in free and antibody-bound horse cytochrome c, a discontiguous, conformational epitope was characterized on this protein antigen.	Lysine	45-51	cytochrome c, somatic	Equus caballus	110-122
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Lysine	48-54	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	156-161
28368536-5	2017	In CD1 mice, made hyperglycemic by streptozotoicin (STZ) injection, cardiac structural alterations were evident at 6 months after STZ treatment and were associated with a significant increase of H3 lysine 27 trimethylation and reduction of H3 lysine 9 acetylation.	Lysine	198-204	CD1 antigen complex	Mus musculus	3-6
28368536-5	2017	In CD1 mice, made hyperglycemic by streptozotoicin (STZ) injection, cardiac structural alterations were evident at 6 months after STZ treatment and were associated with a significant increase of H3 lysine 27 trimethylation and reduction of H3 lysine 9 acetylation.	Lysine	243-249	CD1 antigen complex	Mus musculus	3-6
3105932-1	1987	The enzyme sequentially converts creatine kinase MM3 to MM2 and MM1 and hydrolyzes lysine and arginine from hippuryl-L-lysine and hippuryl-L-arginine.	Lysine	83-89	plexin B2	Homo sapiens	64-67
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Lysine	78-84	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	156-161
11980702-1	2002	Transglutaminase (TGase) enzymes catalyze the formation of covalent cross-links between protein-bound glutamines and lysines in a calcium-dependent manner, but the role of Ca(2+) ions remains unclear.	Lysine	117-124	transglutaminase 1	Homo sapiens	0-16
28539357-1	2017	A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk.	Lysine	15-21	transmembrane 6 superfamily member 2	Homo sapiens	48-84
28539357-1	2017	A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk.	Lysine	15-21	transmembrane 6 superfamily member 2	Homo sapiens	86-92
3095314-3	1986	One of these cleavages occurs at C-1 of the 4-aminobutyl group during its transfer from the secondary amine nitrogen of spermidine to the nitrogen at the epsilon-position of a specific lysine residue in the polypeptide precursor of eukaryotic initiation factor 4D.	Lysine	185-191	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	33-36
11980702-1	2002	Transglutaminase (TGase) enzymes catalyze the formation of covalent cross-links between protein-bound glutamines and lysines in a calcium-dependent manner, but the role of Ca(2+) ions remains unclear.	Lysine	117-124	transglutaminase 1	Homo sapiens	18-23
3095314-4	1986	Breakage of the other -C-H bond takes place at C-2 in this aminobutyl segment after it has been coupled to lysine to form the intermediate deoxyhypusine residue.	Lysine	107-113	complement C2	Homo sapiens	47-50
28438779-6	2017	Moreover, interleukin-4 polarization lowers expression levels of the osteoclast transcriptional activator nuclear factor of activated T cells type c-1, associated with increased gene promoter levels of the transcriptional repression mark H3K27me3 (histone 3 lysine 27 trimethylation).	Lysine	258-264	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	147-150
11953390-4	2002	The purpose of this study was to determine if the arginine- and lysine-specific gingipains of P. gingivalis (i.e., HRgpA and RgpB, and Kgp, respectively) were responsible for the degradation of E-cadherin, the cell-cell adhesion protein in the adherens junctions.	Lysine	64-70	cadherin 1	Canis lupus familiaris	194-204
28131816-7	2017	Mechanistic studies showed that TRAF1 expression enhances the ubiquitination of ERK5 on lysine 184, which is necessary for its kinase activity and AP-1 activation.	Lysine	88-94	TNF receptor-associated factor 1	Mus musculus	32-37
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	214-220	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	153-156
3019766-1	1986	The site-specific chemical modification of horse heart cytochrome c at Lys-13 and -72 using 4-chloro-3,5-dinitrobenzoic acid (CDNB) increases the electron self-exchange rate of the protein.	Lysine	71-74	cytochrome c, somatic	Equus caballus	55-67
11953390-7	2002	Incubation of P. gingivalis cells with immunoprecipitated E-cadherin resulted in degradation, whereas prior exposure of P. gingivalis cells to leupeptin and especially acetyl-Leu-Val-Lys-aldehyde (which are arginine- and lysine-specific inhibitors, respectively) reduced this activity.	Lysine	221-227	cadherin 1	Canis lupus familiaris	58-68
28653878-1	2017	Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression.	Lysine	246-252	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	153-156
11805121-2	2002	The fate of a substrate depends on the number of ubiquitin moieties conjugated, as well as the lysine linkage of Ub-Ub conjugation.	Lysine	95-101	ubiquitin	Saccharomyces cerevisiae S288C	113-115
28428430-1	2017	Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain.	Lysine	120-127	adiponectin, C1Q and collagen domain containing	Mus musculus	41-52
28428430-2	2017	The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its significance in relation to obesity.	Lysine	88-95	adiponectin, C1Q and collagen domain containing	Mus musculus	115-126
2427362-3	1986	Cleavage of Lys(1313)-Glu resulted in two major products, which could be separated by gel chromatography: a large disulfide bridged fragment set nearly the size of intact alpha 2M X MA, and an 18 kDa fragment, constituting the carboxy-terminal domain of alpha 2M.	Lysine	12-15	alpha-2-macroglobulin	Homo sapiens	171-179
2427362-3	1986	Cleavage of Lys(1313)-Glu resulted in two major products, which could be separated by gel chromatography: a large disulfide bridged fragment set nearly the size of intact alpha 2M X MA, and an 18 kDa fragment, constituting the carboxy-terminal domain of alpha 2M.	Lysine	12-15	alpha-2-macroglobulin	Homo sapiens	254-262
3782055-8	1986	Thus, the total sequence of H1b was completely determined; it consists of a total of 218 amino acid residues, has a molecular weight of 21,734 in the unmodified form, and is completely acetylated at the N-terminal serine residue and partially methylated at the lysine residue 25.	Lysine	261-267	H1.5 linker histone, cluster member	Homo sapiens	28-31
11805121-2	2002	The fate of a substrate depends on the number of ubiquitin moieties conjugated, as well as the lysine linkage of Ub-Ub conjugation.	Lysine	95-101	ubiquitin	Saccharomyces cerevisiae S288C	116-118
11805121-7	2002	Our in vivo genetic analysis demonstrates that such interactions require specific lysine residues of Ub that are important for Ub chain formation.	Lysine	82-88	ubiquitin	Saccharomyces cerevisiae S288C	101-103
28510597-8	2017	We now used mass spectrometry to map the lysines in MOF that are ubiquitylated by MSL2 in vitro and identified in vivo ubiquitylation sites of MOF in male and female cells.	Lysine	41-48	males absent on the first	Drosophila melanogaster	52-55
11805121-7	2002	Our in vivo genetic analysis demonstrates that such interactions require specific lysine residues of Ub that are important for Ub chain formation.	Lysine	82-88	ubiquitin	Saccharomyces cerevisiae S288C	127-129
28510597-8	2017	We now used mass spectrometry to map the lysines in MOF that are ubiquitylated by MSL2 in vitro and identified in vivo ubiquitylation sites of MOF in male and female cells.	Lysine	41-48	male-specific lethal 2	Drosophila melanogaster	82-86
3095926-9	1986	It is concluded that the reaction of aspirin with antithrombin III results in specific acetylation of lysine residues.	Lysine	102-108	serpin family C member 1	Homo sapiens	50-66
11805121-10	2002	Our results suggest a molecular mechanism for differentiation of substrate fates, depending on the precise nature of the mono-Ub or multi-Ub lysine linkage, and provide a foundation to further investigate postubiquitylation events.	Lysine	141-147	ubiquitin	Saccharomyces cerevisiae S288C	138-140
27765079-7	2017	In conclusion, results indicate that broilers fed diets with higher levels of digestible lysine have increased messenger RNA expression of some genes coded in the mitochondrial electron transport chain (ND1, CYTB, COX I, COX II and COX III).	Lysine	89-95	cytochrome c oxidase subunit 3	Glycine max	232-239
11972751-6	2002	In the positions with aliphatic amino acids, substitution by tyrosine or phenylalanine, and in the positions with charged amino acids, substitution by aspartic acid or lysine, preserved the affinity to FVIII.	Lysine	168-174	coagulation factor VIII	Homo sapiens	202-207
11923469-0	2002	Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.	Lysine	0-6	hypertrichosis 2 (generalised, congenital)	Homo sapiens	143-145
28289266-6	2017	Unexpectedly, this synergistic signaling occurs downstream of beta-catenin stabilization, and is correlated with increased lysine acetylation of beta-catenin.	Lysine	123-129	catenin beta 1	Homo sapiens	62-74
28289266-6	2017	Unexpectedly, this synergistic signaling occurs downstream of beta-catenin stabilization, and is correlated with increased lysine acetylation of beta-catenin.	Lysine	123-129	catenin beta 1	Homo sapiens	145-157
3085590-3	1986	Spectral analysis of pyridoxal 5"-phosphate-modified phosphoenolpyruvate carboxylase showed absorption maxima at 432 and 327 nm, before and after reduction with NaBH4, respectively, suggesting that epsilon-amino groups of lysine residues are the reactive groups in the enzyme.	Lysine	222-228	MLO-like protein 4	Zea mays	53-84
3085590-5	1986	The absence of modifier bound to phosphoenolpyruvate carboxylase when the modification was carried out in the presence of phosphoenolpyruvate and MgCl2 suggests the existence of an essential lysine residue at the catalytic site of the enzyme.	Lysine	191-197	MLO-like protein 4	Zea mays	33-64
3082364-1	1986	The contribution of lysine and arginine residues to the substrate specificity of the myosin light-chain kinase has been studied using chemically modified myosin light chains.	Lysine	20-26	myosin light chain kinase	Homo sapiens	85-110
11923477-0	2002	Lysine 270 in the third intracellular domain of the oxytocin receptor is an important determinant for G alpha(q) coupling specificity.	Lysine	0-6	oxytocin receptor	Homo sapiens	52-69
3082364-1	1986	The contribution of lysine and arginine residues to the substrate specificity of the myosin light-chain kinase has been studied using chemically modified myosin light chains.	Lysine	20-26	myosin heavy chain 14	Homo sapiens	85-91
3082364-4	1986	In contrast, phosphorylation of the myosin light chains by the cAMP-dependent protein kinase was relatively insensitive to lysine modification, with only a 15% reduction in phosphorylation following succinylation of 50% of the lysine residues.	Lysine	227-233	myosin heavy chain 14	Homo sapiens	36-42
28250117-11	2017	Thus, this is the first report that the E3 ligase PML is capable of stimulating the SUMOylation of a viral protein which is supposed to serve as a cellular mechanism to compromise specific functions of IE1p72.IMPORTANCE The major immediate early proteins of human cytomegalovirus, termed IE1p72 and IE2p86, have previously been shown to undergo posttranslational modification by covalent coupling to SUMO moieties at specific lysine residues.	Lysine	426-432	PML nuclear body scaffold	Homo sapiens	50-53
3082364-8	1986	The results of this study support the concept that lysine and arginine residues act as essential specificity determinants for the myosin light-chain kinase in protein substrates.	Lysine	51-57	myosin light chain kinase	Homo sapiens	130-155
11781322-4	2002	Recently we demonstrated that the primary antiangiogenic plasmin fragment, called A(61) (Lys(78)-Lys(468)) was released from cultured cells.	Lysine	89-92	plasminogen	Homo sapiens	57-64
28430144-6	2017	Dietary lysine excess may lead to: (1) decreased muscle protein degradation via the down-regulated DNAJA1, HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA.	Lysine	8-14	UBE2D3	Sus scrofa	128-134
28408745-3	2017	Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression.	Lysine	40-46	forkhead box P1	Homo sapiens	19-24
3005305-1	1986	Egg white lysozyme, treated with O-methylisourea to convert lysine to homoarginine residues, was used as a substrate for the ATP-dependent proteolytic pathway in rabbit reticulocyte lysates.	Lysine	60-66	lysozyme C-like	Oryctolagus cuniculus	10-18
11781322-4	2002	Recently we demonstrated that the primary antiangiogenic plasmin fragment, called A(61) (Lys(78)-Lys(468)) was released from cultured cells.	Lysine	97-100	plasminogen	Homo sapiens	57-64
11790772-2	2002	Computer modeling of human IL-18 identified two charged residues, Glu-42 and Lys-89, which interact with oppositely charged amino acid residues buried in a large hydrophobic pocket of IL-18BP.	Lysine	77-80	interleukin 18 binding protein	Homo sapiens	184-191
3001047-3	1986	The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c.	Lysine	303-310	cytochrome c, somatic	Equus caballus	30-42
3001047-3	1986	The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c.	Lysine	303-310	cytochrome c, somatic	Equus caballus	56-68
3001047-3	1986	The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c.	Lysine	303-310	cytochrome c, somatic	Equus caballus	56-68
28380336-2	2017	(2017) expand our understanding of what reader domains bind to by showing that MORF, a double PHD domain containing lysine acetyltransferase, is a preferential reader of histone lysine acylation.	Lysine	116-122	lysine acetyltransferase 6B	Homo sapiens	79-83
28103160-4	2017	Here we report dual acetylation at the serine and lysine residues by transiently expressed serine acetyltransferase YopJ mimicking Y. pestis infection in HeLa cells.	Lysine	50-56	targeted effector protein	Yersinia pestis	116-120
3001047-3	1986	The recognition site for flavocytochrome c552 on equine cytochrome c has been deduced by differential chemical modification of cytochrome c in the presence and absence of flavocytochrome c552 and by kinetic analysis of the sulfide:cytochrome c oxidoreductase activity of m-trifluoromethylphenylcarbamoyl-lysine derivatives of cytochrome c.	Lysine	303-310	cytochrome c, somatic	Equus caballus	56-68
11790772-10	2002	The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP.	Lysine	42-45	interleukin 18 binding protein	Homo sapiens	227-234
28103160-5	2017	Using shotgun proteomics followed by label-free quantification, we demonstrate an increase of dual acetylation in YopJ transfected human cells, including 10 Ser- (YopJ/non-YopJ 1.3-fold, p = 0.02) and 8 Lys- (YopJ/non-YopJ 3.5-fold, p = 0.00003) acetylation sites.	Lysine	203-206	targeted effector protein	Yersinia pestis	114-118
28103160-6	2017	Specifically, YopJ expression augments acetylation of membrane-associated E3 ubiquitin ligase MARCH8 at the serine residue Sac44, Sac71 and Sac253, and the lysine residue Kac247 and Kac252.	Lysine	156-162	targeted effector protein	Yersinia pestis	14-18
28103160-7	2017	YopJ-mediated Ser- and Lys-acetylation of MARCH8 is further confirmed by Western blotting using the specific antibodies against MARCH8 Sac71 and pan-acetyl lysine.	Lysine	23-26	targeted effector protein	Yersinia pestis	0-4
28103160-8	2017	Functional study demonstrates that YopJ-mediated Ser- and Lys-acetylation affects the auto-ubiquitination of MARCH8.	Lysine	58-61	targeted effector protein	Yersinia pestis	35-39
11779867-5	2002	Interestingly, the single mutation K523R completely abolished modification of c-Myb with SUMO-1, suggesting that sumolation of Lys(523) is required for modification of other lysines in c-Myb.	Lysine	127-130	small ubiquitin like modifier 1	Homo sapiens	89-95
28103160-9	2017	The mutant C172A of YopJ previously shown to abolish the acetyltransferase activity also reduces Ser- and Lys-acetylation and diminishes the auto-ubiquitination of MARCH8.	Lysine	106-109	targeted effector protein	Yersinia pestis	20-24
28103160-10	2017	In support, MARCH8 is indeed acetylated at serine and lysine in vitro by purified YopJ but the activity is reduced by the C172A mutant in YopJ.	Lysine	54-60	targeted effector protein	Yersinia pestis	82-86
28103160-11	2017	Our study provides evidence that bacterial serine acetyltransferase YopJ mediates Ser- and Lys-acetylation and affects auto-ubiquitination of ubiquitin ligase MARCH8 in human cells.	Lysine	91-94	targeted effector protein	Yersinia pestis	68-72
4066692-6	1985	Computer modeling implicates lysines 47, 50, and 98 of metMb as contact points with cytochrome b5 carboxylate residues 43, 44, 60, and heme 6-propionate.	Lysine	29-36	cytochrome b5 type A	Homo sapiens	84-97
11779867-6	2002	In accordance with this observation, we found that the SUMO-1-conjugating enzyme Ubc9 interacted only with a region surrounding Lys(523) (also called the PEST/EVES motif).	Lysine	128-131	small ubiquitin like modifier 1	Homo sapiens	55-61
4066692-10	1985	This study suggests a function for the three exterior lysine residues conserved in all mammalian myoglobin sequences: they are contact points for complexation with cytochrome b5.	Lysine	54-60	cytochrome b5 type A	Homo sapiens	164-177
11779867-6	2002	In accordance with this observation, we found that the SUMO-1-conjugating enzyme Ubc9 interacted only with a region surrounding Lys(523) (also called the PEST/EVES motif).	Lysine	128-131	ubiquitin conjugating enzyme E2 I	Homo sapiens	81-85
28287409-4	2017	Mechanistically, we determined that SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 levels.	Lysine	167-174	sirtuin 2	Mus musculus	36-41
11876646-0	2002	Topology of the anion exchange protein AE1: the controversial sidedness of lysine 743.	Lysine	75-81	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	39-42
28083916-4	2017	A novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, K274, and K281, which are associated with dementia in Alzheimer"s disease (AD).	Lysine	102-109	microtubule associated protein tau	Homo sapiens	33-36
28083916-4	2017	A novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, K274, and K281, which are associated with dementia in Alzheimer"s disease (AD).	Lysine	102-109	microtubule associated protein tau	Homo sapiens	113-116
28083916-5	2017	We propose that an increase in tau acetylated on these lysines blocks the expression of long-term potentiation at hippocampal synapses leading to impaired memory in AD.	Lysine	55-62	microtubule associated protein tau	Homo sapiens	31-34
2989266-4	1985	We now show that this enzyme hydrolyzes amide derivatives of the ubiquitin carboxyl terminus, including those of lysine (epsilon-amino), glycine methyl ester, and spermidine.	Lysine	113-119	ubiquitin	Oryctolagus cuniculus	65-74
2989266-6	1985	Amide adducts formed between ubiquitin and epsilon-amino groups of protein lysine residues are much poorer substrates than is the ubiquitin amide of the epsilon-amino group of free lysine.	Lysine	75-81	ubiquitin	Oryctolagus cuniculus	29-38
2989266-6	1985	Amide adducts formed between ubiquitin and epsilon-amino groups of protein lysine residues are much poorer substrates than is the ubiquitin amide of the epsilon-amino group of free lysine.	Lysine	75-81	ubiquitin	Oryctolagus cuniculus	130-139
2989266-6	1985	Amide adducts formed between ubiquitin and epsilon-amino groups of protein lysine residues are much poorer substrates than is the ubiquitin amide of the epsilon-amino group of free lysine.	Lysine	181-187	ubiquitin	Oryctolagus cuniculus	29-38
2989266-6	1985	Amide adducts formed between ubiquitin and epsilon-amino groups of protein lysine residues are much poorer substrates than is the ubiquitin amide of the epsilon-amino group of free lysine.	Lysine	181-187	ubiquitin	Oryctolagus cuniculus	130-139
3927977-2	1985	We have measured the relative reactivities of lysines in rabbit skeletal muscle alpha, alpha-tropomyosin with acetic anhydride using a competitive labeling procedure.	Lysine	46-53	tropomyosin alpha-1 chain	Oryctolagus cuniculus	87-104
11853669-1	2002	E2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues directly or through E3-mediated reactions.	Lysine	75-81	ubiquitin	Saccharomyces cerevisiae S288C	34-43
4030949-9	1985	Comparison of the peptide maps between a single-chain and a degraded form of ceruloplasmin facilitated the identification of two tryptic peptides, derived from the carboxyl-terminal regions of 67 kDa and 50 kDa fragments of the degraded form, which lack the carboxyl-terminal arginine and lysine residues, respectively.	Lysine	289-295	ceruloplasmin	Homo sapiens	77-90
27863698-7	2017	Targeted investigation of GRIA1, a glutamatergic gene implicated in drug-seeking behavior, verified the increased enrichment of lysine-27 acetylated histone H3 at discrete loci, accompanied by enhanced chromatin accessibility at hyperacetylated regions in the gene body.	Lysine	128-134	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	26-31
28084329-3	2017	EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1.	Lysine	171-177	epidermal growth factor	Homo sapiens	0-3
28084329-3	2017	EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1.	Lysine	171-177	splA/ryanodine receptor domain and SOCS box containing 1	Homo sapiens	63-104
11853669-1	2002	E2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues directly or through E3-mediated reactions.	Lysine	75-81	ubiquitin	Saccharomyces cerevisiae S288C	48-57
28084329-3	2017	EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1.	Lysine	171-177	splA/ryanodine receptor domain and SOCS box containing 1	Homo sapiens	106-111
3923165-4	1985	Serum somatomedin (Sm) activity was significantly decreased in lysine- (0.55 U/ml), methionine- (0.32 U/ml) and histidine-deficient (0.38 U/ml) rats compared to rats fed the control diet ad libitum (1.6 U/ml).	Lysine	63-69	insulin-like growth factor 1	Rattus norvegicus	6-17
11853669-3	2002	In contrast to most ubiquitin conjugation, the SUMO E2 enzyme Ubc9 is sufficient for substrate recognition and lysine modification of known SUMO targets.	Lysine	111-117	ubiquitin conjugating enzyme E2 I	Homo sapiens	62-66
11711550-10	2002	Surprisingly, heparin at concentrations that can be achieved in vivo during anticoagulation therapy greatly enhances the plasmin-mediated cleavage of the Lys(317)-Thr(318) site in beta2-GPI.	Lysine	154-157	plasminogen	Homo sapiens	121-128
28017832-6	2017	Confirming the cell-based experiments, we found deficient LH3-specific collagen lysine modifications in patients" urine and skin fibroblasts.	Lysine	80-86	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	58-61
11802713-0	2002	Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10.	Lysine	28-34	lipoprotein(a)	Homo sapiens	62-79
28447071-1	2017	BACKGROUND: Rpd3 is a conserved histone deacetylase that removes acetyl groups from lysine residues within histones and other proteins.	Lysine	84-90	Histone deacetylase 1	Drosophila melanogaster	12-16
3156136-8	1985	This sequence, -Cys-(Ser/Thr)-Asp(P)-Lys-, is similar to that in the calcium ion-transport ATPase of sarcoplasmic reticulum.	Lysine	37-40	ATPase	Zea mays	91-97
11928808-0	2002	The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.	Lysine	152-158	matrix metallopeptidase 2	Homo sapiens	26-52
28052935-5	2017	We identified two critical amino acid residues within the PH domain of SKAP55, aspartic acid 120 (D120) and lysine 152 (K152).	Lysine	108-114	src kinase associated phosphoprotein 1	Homo sapiens	71-77
11928808-0	2002	The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.	Lysine	152-158	matrix metallopeptidase 2	Homo sapiens	54-59
3889695-3	1985	The enzyme specifically cleaved the Lys-Arg bonds of two synthetic peptides containing the subsequence of proenkephalin A, but endogenous opioid peptides containing a single basic residue in the molecule [Met)enk-Arg-Phe, (Met)enk-Arg-Gly-Leu) were not affected by the enzyme.	Lysine	36-39	proenkephalin	Bos taurus	106-121
12900547-4	2002	At PGK1 and HPRT, chromatin on the active X chromosome reveals H3 lysine 4 methylation and acetylation of histones H3 and H4.	Lysine	66-72	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	12-16
2981069-7	1985	The effect of PLP was readily reversed by the addition of lysine.	Lysine	58-64	proteolipid protein 1	Bos taurus	14-17
28154176-3	2017	Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role of this residue in intrinsic KRAS function has not been well characterized.	Lysine	0-6	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	14-18
28154176-4	2017	We find that lysine 104 is important for GEF recognition, because mutations at this position impaired GEF-mediated nucleotide exchange.	Lysine	13-19	rho/rac guanine nucleotide exchange factor (GEF) 2	Mus musculus	41-44
28154176-4	2017	We find that lysine 104 is important for GEF recognition, because mutations at this position impaired GEF-mediated nucleotide exchange.	Lysine	13-19	rho/rac guanine nucleotide exchange factor (GEF) 2	Mus musculus	102-105
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Lysine	116-122	carboxypeptidase B2	Homo sapiens	29-47
28300060-3	2017	Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on lysine 23/36/37 residues, which specifically recruits histone acetyltransferase GCN5 for subsequent H3 acetylation.	Lysine	104-110	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	70-75
6241479-7	1984	In addition, the NBD label has been used, after its transfer from the essential Tyr to the essential Lys, as an internal fluorescent probe to monitor protein conformation change at the active site of MF1.	Lysine	101-104	flap structure-specific endonuclease 1	Homo sapiens	200-203
6437449-6	1984	NH2-terminal and amino acid analyses demonstrated this peptide to be derived from residues 51 to 62, with Lys-61 proposed as the major FITC-sensitive site on actin.	Lysine	106-109	actin	Oryctolagus cuniculus	158-163
6437449-10	1984	Therefore, either a localized conformational change near Lys-61 or steric hindrance due to the FITC attached to Lys-61 blocks the polymerization of actin.	Lysine	57-60	actin	Oryctolagus cuniculus	148-153
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Lysine	116-122	carboxypeptidase B2	Homo sapiens	49-52
6437449-10	1984	Therefore, either a localized conformational change near Lys-61 or steric hindrance due to the FITC attached to Lys-61 blocks the polymerization of actin.	Lysine	112-115	actin	Oryctolagus cuniculus	148-153
28281974-3	2017	In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site.	Lysine	188-194	ATPase H+/K+ transporting subunit beta	Homo sapiens	43-48
28281974-6	2017	Chromatin immunoprecipitation (ChIP) showed that, in BGC823 GC cells, histone H3 lysine 9 acetylation (H3K9ac) was enhanced in the intragenic region of ATP4B upon TSA treatment, whereas 5-AZA showed a minimal effect.	Lysine	81-87	ATPase H+/K+ transporting subunit beta	Homo sapiens	152-157
12478568-1	2002	Guanidination has been used to investigate how modification of the lysine eta-amino group into the corresponding guanidino group affects response in electrospray (ES) mass spectrometry (MS).	Lysine	67-73	endothelin receptor type A	Homo sapiens	74-77
28104757-3	2017	Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein.	Lysine	139-145	gremlin 2, DAN family BMP antagonist	Homo sapiens	55-64
28104757-3	2017	Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a series of lysine residues cluster along one face of the protein.	Lysine	139-145	gremlin 2, DAN family BMP antagonist	Homo sapiens	66-71
28104757-4	2017	In the present study, we used mutagenesis, heparin-binding measurements, and cell surface-binding analysis to identify lysine residues that are important for heparin/HS binding in Grem2.	Lysine	119-125	gremlin 2, DAN family BMP antagonist	Homo sapiens	180-185
6147349-0	1984	Modification of Lys-237 on actin by 2,4-pentanedione.	Lysine	16-19	actin	Oryctolagus cuniculus	27-32
6147349-2	1984	It has been possible to specifically label rabbit skeletal muscle actin at Lys-237 with 2,4-pentanedione, producing an enamine.	Lysine	75-78	actin	Oryctolagus cuniculus	66-71
6206897-3	1984	Because glutamic acid residue in position gamma 101 is involved in the alpha 1-gamma 2 chain contact, its replacement by a lysine residue results in changes in physicochemical and functional properties.	Lysine	123-129	adrenoceptor alpha 1D	Homo sapiens	71-86
28054303-8	2017	We propose that these four prolines and four lysines in a Kv1.4 homotetramer might provide a binding site for a putative endoplasmic reticulum-export molecule to ensure high cell surface protein expression of the channel.	Lysine	45-52	potassium voltage-gated channel subfamily A member 4	Homo sapiens	58-63
11598140-4	2001	The greatest sensitivity to canavanine was observed in cells expressing a mutant version of ubiquitin unable to support the formation of Lys(48) linkages.	Lysine	137-140	ubiquitin	Saccharomyces cerevisiae S288C	92-101
28104734-5	2017	MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.	Lysine	71-77	membrane associated ring-CH-type finger 5	Homo sapiens	0-6
11719561-6	2001	Mutation of all lysine residues of a truncated GHR (GHR-399K-) precludes ubiquitination of the receptor, but internalization of GHR-399K- still depends on an active ubiquitin system.	Lysine	16-22	growth hormone receptor	Cricetulus griseus	47-50
28114273-2	2017	Genetic studies suggest that the PKMTs SUV420H1 and SUV420H2 facilitate proficient nonhomologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation (me2 and me3, respectively) of lysine 20 on histone 4 (H4K20).	Lysine	208-214	lysine methyltransferase 5B	Homo sapiens	39-47
28114273-2	2017	Genetic studies suggest that the PKMTs SUV420H1 and SUV420H2 facilitate proficient nonhomologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation (me2 and me3, respectively) of lysine 20 on histone 4 (H4K20).	Lysine	208-214	lysine methyltransferase 5C	Homo sapiens	52-60
11719561-6	2001	Mutation of all lysine residues of a truncated GHR (GHR-399K-) precludes ubiquitination of the receptor, but internalization of GHR-399K- still depends on an active ubiquitin system.	Lysine	16-22	growth hormone receptor	Cricetulus griseus	52-61
11719561-6	2001	Mutation of all lysine residues of a truncated GHR (GHR-399K-) precludes ubiquitination of the receptor, but internalization of GHR-399K- still depends on an active ubiquitin system.	Lysine	16-22	growth hormone receptor	Cricetulus griseus	52-55
11602710-5	2001	Lysine 450 was mapped as the major SUMO-1 conjugation site, but a point mutation of this lysine residue in IE1 did not interfere with its targeting to and disruption of the PODs.	Lysine	0-6	small ubiquitin like modifier 1	Homo sapiens	35-41
28088282-2	2017	During production, the DM1 agents were conjugated to the lysine residues of the mAb in a non-specific manner, yielding a heterogeneous mixture of ADC molecules that differ with respect to both the number and the conjugation sites of DM1 per mAb molecule.	Lysine	57-63	immunoglobulin heavy diversity 1-7	Homo sapiens	23-26
28088282-4	2017	Herein, we have employed a signature ion fingerprinting approach to specifically determine lysine residues with DM1 conjugation, and developed a normalized peak area quantitation method to characterize the percentage of DM1-conjugated lysine for each putative site using a T-DM1 biosimilar as a model drug.	Lysine	91-97	immunoglobulin heavy diversity 1-7	Homo sapiens	112-115
28088282-4	2017	Herein, we have employed a signature ion fingerprinting approach to specifically determine lysine residues with DM1 conjugation, and developed a normalized peak area quantitation method to characterize the percentage of DM1-conjugated lysine for each putative site using a T-DM1 biosimilar as a model drug.	Lysine	235-241	immunoglobulin heavy diversity 1-7	Homo sapiens	220-223
28088282-4	2017	Herein, we have employed a signature ion fingerprinting approach to specifically determine lysine residues with DM1 conjugation, and developed a normalized peak area quantitation method to characterize the percentage of DM1-conjugated lysine for each putative site using a T-DM1 biosimilar as a model drug.	Lysine	235-241	immunoglobulin heavy diversity 1-7	Homo sapiens	220-223
28088282-5	2017	With this integrative approach, 38 lysine residues were identified with DM1 conjugation among 90 possible sites.	Lysine	35-41	immunoglobulin heavy diversity 1-7	Homo sapiens	72-75
28088282-6	2017	More interestingly, we found that the T-DM1 biosimilar exhibited a specific preference of DM1-conjugation for several lysine residues, and such preference was consistent among three production batches.	Lysine	118-124	immunoglobulin heavy diversity 1-7	Homo sapiens	40-43
28088282-6	2017	More interestingly, we found that the T-DM1 biosimilar exhibited a specific preference of DM1-conjugation for several lysine residues, and such preference was consistent among three production batches.	Lysine	118-124	immunoglobulin heavy diversity 1-7	Homo sapiens	90-93
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Lysine	35-38	C-terminal Src kinase	Homo sapiens	64-67
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Lysine	35-38	prolyl endopeptidase	Homo sapiens	189-192
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	87-93	sirtuin 1	Mus musculus	47-52
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	87-93	sirtuin 1	Mus musculus	71-76
11572945-3	2001	Mutagenesis studies with the human enzyme in which the invariant histidines and lysines of the HKD motifs are changed confirm that these highly conserved residues are essential for Tdp1 activity.	Lysine	80-87	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	181-185
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	214-220	sirtuin 1	Mus musculus	47-52
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	214-220	sirtuin 1	Mus musculus	71-76
11570872-6	2001	However, the natural regakine-1 protein missed the COOH-terminal lysine residue.	Lysine	65-71	regakine-1	Bos taurus	21-31
28028172-3	2017	Inhibition of HDAC1 resulted in increase of acetylation of lysine 9 of histone 3 (H3K9) and lysine 12 of histone 4 (H4K12) but not lysine 27 of histone 3 (H3K27) and led to maintained expression of progenitor-specific genes such as Vsx2 and Hes1 with concomitant block of expression of rod-specific genes.	Lysine	92-98	histone deacetylase 1	Mus musculus	14-19
28232907-1	2017	The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias.	Lysine	54-60	lysine methyltransferase 2A	Homo sapiens	4-28
28232907-1	2017	The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias.	Lysine	54-60	lysine methyltransferase 2A	Homo sapiens	30-34
28232907-1	2017	The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias.	Lysine	54-60	lysine methyltransferase 2A	Homo sapiens	98-103
11473115-0	2001	Identification of a critical lysine residue in apolipoprotein B-100 that mediates noncovalent interaction with apolipoprotein(a).	Lysine	29-35	lipoprotein(a)	Homo sapiens	111-128
28069388-7	2017	Renal tissues of VDR-M mice showed acetylation of p53 at lysine (K) 382 residues inferring that enhanced p53 expression in renal tissues could be the result of ongoing acetylation, a consequence of SIRT1 deficient state.	Lysine	57-63	transformation related protein 53, pseudogene	Mus musculus	50-53
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	41-47	lipoprotein(a)	Homo sapiens	149-155
28069388-8	2017	Notably, podocytes lacking SIRT1 not only showed acetylation of p53 at lysine (K) 382 residues but also displayed enhanced p53 expression.	Lysine	71-77	sirtuin 1	Mus musculus	27-32
28069388-8	2017	Notably, podocytes lacking SIRT1 not only showed acetylation of p53 at lysine (K) 382 residues but also displayed enhanced p53 expression.	Lysine	71-77	transformation related protein 53, pseudogene	Mus musculus	64-67
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	41-47	lipoprotein(a)	Homo sapiens	242-247
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	197-203	lipoprotein(a)	Homo sapiens	149-155
11473115-2	2001	In the present study, citraconylation of lysine residues in apoB-100 abolished the ability of the modified low density lipoprotein to associate with apo(a), thereby demonstrating a direct role for lysine residues in apoB in the first step of Lp(a) assembly.	Lysine	197-203	lipoprotein(a)	Homo sapiens	242-247
27648820-7	2017	Out of the 19 Aminated-ELP coatings tested, we found that the lysine-containing substrates comprising ELP-polylysine or ELP-PVDMA-butanediamine proved to consistently culture productive spheroidal hepatocytes.	Lysine	62-68	nuclear receptor subfamily 5 group A member 1	Homo sapiens	23-26
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	203-209	lipoprotein(a)	Homo sapiens	191-197
27648820-7	2017	Out of the 19 Aminated-ELP coatings tested, we found that the lysine-containing substrates comprising ELP-polylysine or ELP-PVDMA-butanediamine proved to consistently culture productive spheroidal hepatocytes.	Lysine	62-68	nuclear receptor subfamily 5 group A member 1	Homo sapiens	102-105
27648820-7	2017	Out of the 19 Aminated-ELP coatings tested, we found that the lysine-containing substrates comprising ELP-polylysine or ELP-PVDMA-butanediamine proved to consistently culture productive spheroidal hepatocytes.	Lysine	62-68	nuclear receptor subfamily 5 group A member 1	Homo sapiens	102-105
11473115-4	2001	Assessment of the ability of carboxyl-terminal truncations of apoB-18 to bind to r-apo(a)-Sepharose revealed that a 25-amino acid sequence in apoB (amino acids 680-704) bound specifically to apo(a) in a lysine-dependent manner; citraconylation of the lysine residues in the apoB derivative encoding this sequence abolished the binding interaction.	Lysine	251-257	lipoprotein(a)	Homo sapiens	191-197
27648820-8	2017	We suggest that the incorporation of lysine functional groups in Aminated-ELP rendered more biocompatible surfaces, increasing spheroid attachment and leading to increased liver-specific function.	Lysine	37-43	nuclear receptor subfamily 5 group A member 1	Homo sapiens	74-77
11509612-3	2001	The crystal structure of HLA-DR2 complexed with myelin basic protein(84-102) confirmed that Lys(91) is the major TCR contact site, whereas Phe(90) is a major anchor to MHC and binds the hydrophobic P4 pocket (2 ).	Lysine	92-95	myelin basic protein	Homo sapiens	48-68
27581538-8	2017	Pharmacologic inhibition of IDO1 in HSCs by 1-methyltryptophan (1MT) inhibited LPS/HSC-induced AhR signaling in nTregs, which was responsible for their expansion, Foxp3 expression, and stabilization of Foxp3 by increasing acetylation of lysine residues.	Lysine	237-243	indoleamine 2,3-dioxygenase 1	Mus musculus	28-32
27581538-9	2017	Finally, HSCs cryopreserved, following 2-3 passages, were as potent as primary-cultured HSCs in expanding nTregs In conclusion, LPS/HSCs expand allogeneic nTregs through an IDO-dependent, AhR-mediated mechanism and increase their stability through lysine-acetylation of Foxp3.	Lysine	248-254	indoleamine 2,3-dioxygenase 1	Mus musculus	173-176
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	Lysine	72-75	lysine acetyltransferase 2B	Homo sapiens	138-170
27903803-15	2017	We show that tight binding of IE1 to PML interferes with the de novo SUMOylation of a distinct lysine residue that is also the target of stress-mediated hyperSUMOylation of PML.	Lysine	95-101	PML nuclear body scaffold	Homo sapiens	37-40
27903803-15	2017	We show that tight binding of IE1 to PML interferes with the de novo SUMOylation of a distinct lysine residue that is also the target of stress-mediated hyperSUMOylation of PML.	Lysine	95-101	PML nuclear body scaffold	Homo sapiens	173-176
11509661-6	2001	Acetylation of the Lys residue in this motif, demonstrated in vivo by using an acetylated RIP140-specific antibody, dramatically reduced CtBP binding.	Lysine	19-22	nuclear receptor interacting protein 1	Homo sapiens	90-96
11543766-1	2001	A nonapeptide derived from the C terminus of the insulin B chain, H(2)N-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala-COOH, was found to strongly inhibit dopamine (DA) uptake by rat dopamine transporter (DAT) stably expressed in CHO cells (designated D8 cells).	Lysine	100-103	solute carrier family 6 member 3	Rattus norvegicus	172-192
27924031-4	2017	We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues.	Lysine	158-164	nei like DNA glycosylase 1	Homo sapiens	68-73
27924031-4	2017	We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues.	Lysine	158-164	nei like DNA glycosylase 1	Homo sapiens	125-130
11543766-1	2001	A nonapeptide derived from the C terminus of the insulin B chain, H(2)N-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala-COOH, was found to strongly inhibit dopamine (DA) uptake by rat dopamine transporter (DAT) stably expressed in CHO cells (designated D8 cells).	Lysine	100-103	solute carrier family 6 member 3	Rattus norvegicus	194-197
27865928-6	2017	Furthermore, we demonstrated that BRM was directly recruited to the cis-regulatory regions of PORC, but not of PORA and PORB, at least partially in a PIF1-dependent manner and the level of histone H3 lysine 4 tri-methylation (H3K4me3) at PORC loci was increased in the brm mutant.	Lysine	200-206	transcription regulatory protein SNF2	Arabidopsis thaliana	34-37
11523781-5	2001	Moreover, the rad1 ntg1 ntg2 strain is hypermutable (CanR and Lys+) upon exposure to H2O2, relative to WT, rad1 and ntg1 ntg2 strains.	Lysine	62-65	bifunctional N-glycosylase/AP lyase NTG1	Saccharomyces cerevisiae S288C	19-23
29178074-5	2017	USP30 preferentially mediates the removal of Ub chains from Lys 6 and Lys 11 on mitochondria-derived proteins.	Lysine	60-63	ubiquitin specific peptidase 30	Homo sapiens	0-5
29178074-5	2017	USP30 preferentially mediates the removal of Ub chains from Lys 6 and Lys 11 on mitochondria-derived proteins.	Lysine	70-73	ubiquitin specific peptidase 30	Homo sapiens	0-5
11523781-5	2001	Moreover, the rad1 ntg1 ntg2 strain is hypermutable (CanR and Lys+) upon exposure to H2O2, relative to WT, rad1 and ntg1 ntg2 strains.	Lysine	62-65	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	24-28
11323416-5	2001	Substitution of Met(293) or Lys(320), another residue of the putative substrate specificity motif, which in the predicted three-dimensional structure is located in close proximity to Met(293), by smaller amino acids converted At4CL2 to an enzyme capable of using ferulate.	Lysine	28-31	4-coumarate:CoA ligase 2	Arabidopsis thaliana	226-232
27560128-8	2017	In contrast, the association of Cav-1 promoter with the active histone modification mark, H3 lysine 4 trimethylation, correlated with Cav-1 down-regulation in activated/fibrotic lung fibroblasts.	Lysine	93-99	caveolin 1, caveolae protein	Mus musculus	32-37
27560128-8	2017	In contrast, the association of Cav-1 promoter with the active histone modification mark, H3 lysine 4 trimethylation, correlated with Cav-1 down-regulation in activated/fibrotic lung fibroblasts.	Lysine	93-99	caveolin 1, caveolae protein	Mus musculus	134-139
27560128-9	2017	Our data indicate that Cav-1 gene silencing in lung fibroblasts is actively regulated by epigenetic mechanisms that involve histone modifications, in particular H3 lysine 4 trimethylation, whereas DNA methylation does not appear to be a primary mechanism.	Lysine	164-170	caveolin 1, caveolae protein	Mus musculus	23-28
11451447-10	2001	This suggests that both receptors have the same or at least a very similar hormone binding site which is in close contact to Tyr(22) and Lys(15) located in the carboxy-terminal alpha-helical region of the PACAP-27 molecule.	Lysine	137-140	adenylate cyclase activating polypeptide 1	Rattus norvegicus	205-210
27640900-3	2017	The current study demonstrated that the amino acids histidine, lysine, threonine inhibited mTOR signaling and IgE-mediated mast cell activation, while the amino acids leucine, isoleucine, valine had no effect on mTOR signaling in BMMCs.	Lysine	63-69	mechanistic target of rapamycin kinase	Mus musculus	91-95
11396898-0	2001	Lysine-derivatized polyurethane as a clot lysing surface: conversion of adsorbed plasminogen to plasmin and clot lysis in vitro.	Lysine	0-6	plasminogen	Homo sapiens	81-88
27926813-6	2017	HTR11 is a unique H3 variant that lacks lysine at positions 9 and 27.	Lysine	40-46	histone 3 11	Arabidopsis thaliana	0-5
6430612-4	1984	PAF has been purified from Epstein-Barr (EB) virus genome carrying lymphoid lines by affinity chromatography using lysine-Sepharose columns.	Lysine	115-121	PCNA clamp associated factor	Homo sapiens	0-3
11309403-2	2001	Lysine residues in APC at positions 37, 38, and 39 form a secondary binding site for FVa, which is important for cleavage of FVa at Arg-506 while having no effect on Arg-306 cleavage.	Lysine	0-6	APC regulator of WNT signaling pathway	Homo sapiens	19-22
6424960-4	1984	The carboxy terminal amino acid of human, canine, and rabbit tissue MM3 was determined to be lysine, a specific substrate for carboxypeptidases N and B. Evidently the mechanism for the production of multiple forms of creatine MM in human plasma is the hydrolysis of a positively charged C-terminal lysine residue from one M subunit (MM2), followed by hydrolysis of the C-terminal lysine from the other subunit (MM1).	Lysine	93-99	plexin B2	Homo sapiens	411-414
6425061-3	1984	20 mM lysine, 1,2-diaminoethane, 1,3-diaminopropane, 1,4-diaminobutane or 1,5-diaminopentane are able to dissociate C1 into its two entities, C1q and the calcium-dependent C1r2-C1s2 complex.	Lysine	6-12	complement C1q A chain	Homo sapiens	142-145
6425061-4	1984	Ig-ovalbumin insoluble complexes bearing C1 are also dissociated by lysine and the above-mentioned diamines used at the same concentration: C1q remains bound to the complexes whereas the C1r2-C1s2 complex is partially solubilized.	Lysine	68-74	complement C1q A chain	Homo sapiens	140-143
27768594-1	2016	We previously showed that hepatitis B virus (HBV) X protein (HBx) could promote the trimethylation of histone H3 lysine 9 (H3K9me3) to repress tumor suppressor genes in hepatocellular carcinoma (HCC).	Lysine	113-119	X protein	Hepatitis B virus	61-64
27613418-4	2016	Furthermore, we found that HOXB9 is acetylated at lysine 27 (AcK27).	Lysine	50-56	homeobox B9	Homo sapiens	27-32
11309403-3	2001	In contrast, topological neighbors Lys-62, Lys-63, and Arg-74 in APC appear of minor importance in FVa degradation.	Lysine	35-38	APC regulator of WNT signaling pathway	Homo sapiens	65-68
11309403-3	2001	In contrast, topological neighbors Lys-62, Lys-63, and Arg-74 in APC appear of minor importance in FVa degradation.	Lysine	43-46	APC regulator of WNT signaling pathway	Homo sapiens	65-68
27803159-1	2016	Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links.	Lysine	57-63	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-19
11259410-6	2001	The SUMO-1 consensus sequence (SUMO-1-CS) is a motif of conserved residues surrounding the modified lysine residue of most SUMO-1 substrates.	Lysine	100-106	small ubiquitin like modifier 1	Homo sapiens	4-10
27803159-1	2016	Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links.	Lysine	57-63	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	21-24
6698980-19	1984	These two models can be positioned such that the three lysine residues in the alpha-helix can be matched for maximal interaction with the three sulfate groups in the octasaccharide demonstrated as essential for binding antithrombin III.	Lysine	55-61	serpin family C member 1	Homo sapiens	219-235
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Lysine	65-73	histone deacetylase 8	Homo sapiens	0-21
11259410-6	2001	The SUMO-1 consensus sequence (SUMO-1-CS) is a motif of conserved residues surrounding the modified lysine residue of most SUMO-1 substrates.	Lysine	100-106	small ubiquitin like modifier 1	Homo sapiens	31-37
27933794-1	2016	Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-l-lysine to yield products l-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+).	Lysine	65-73	histone deacetylase 8	Homo sapiens	23-28
6324739-6	1984	The failure of the redox potential of Saccharomyces cerevisae cytochrome c to be affected by acetimidylation suggests that it is lysine-53, absent from that species, that is the sensitive residue.	Lysine	129-135	cytochrome c, somatic	Equus caballus	62-74
6420409-0	1984	Pyridoxylation of essential lysines in the heparin-binding site of antithrombin III.	Lysine	28-35	serpin family C member 1	Homo sapiens	67-83
6420409-1	1984	Pyridoxal 5"-phosphate was used to selectively modify lysine residues on antithrombin III.	Lysine	54-60	serpin family C member 1	Homo sapiens	73-89
27845892-7	2016	H19 was further confirmed to suppress the promoter activity of BIK by recruiting EZH2 and by trimethylating the histone H3 at lysine 27.	Lysine	126-132	H19 imprinted maternally expressed transcript	Homo sapiens	0-3
11259410-6	2001	The SUMO-1 consensus sequence (SUMO-1-CS) is a motif of conserved residues surrounding the modified lysine residue of most SUMO-1 substrates.	Lysine	100-106	small ubiquitin like modifier 1	Homo sapiens	31-37
11259410-7	2001	This motif conforms to the sequence "PsiKXE," where Psi is a large hydrophobic residue, K is the lysine to which SUMO-1 is conjugated, X is any amino acid, and E is glutamic acid.	Lysine	97-103	small ubiquitin like modifier 1	Homo sapiens	113-119
11259410-10	2001	These findings have important implications for how SUMO-1 substrates are recognized and for how SUMO-1 is ultimately transferred to specific lysine residues on these substrates.	Lysine	141-147	small ubiquitin like modifier 1	Homo sapiens	51-57
11259410-10	2001	These findings have important implications for how SUMO-1 substrates are recognized and for how SUMO-1 is ultimately transferred to specific lysine residues on these substrates.	Lysine	141-147	small ubiquitin like modifier 1	Homo sapiens	96-102
29657272-1	2016	Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins.	Lysine	63-69	KMT5A pseudogene 1	Homo sapiens	0-4
11389038-4	2001	Plasmin-mediated mRNA expression was inhibited in a concentration-dependent manner by the lysine analogue trans-4-(aminomethyl)cyclohexane-1-carboxylic acid (t-AMCA).	Lysine	90-96	plasminogen	Homo sapiens	0-7
27071708-9	2016	Promoter methylation of several other genes and repressive histone H3 lysine 27 trimethylation by EZH2 of the HIC1 gene may also contribute to parathyroid tumorigenesis.	Lysine	70-76	HIC ZBTB transcriptional repressor 1	Homo sapiens	110-114
6229282-1	1984	Opsin readily undergoes Schiff base formation between an active site lysine and 9-cis- or 11-cis-retinaldehyde to form the visual pigments isorhodopsin (lambda max = 487 nm) and rhodopsin (lambda max = 500 nm), respectively (Dratz, 1977).	Lysine	69-75	rhodopsin	Bos taurus	142-151
11699729-3	2001	It is now generally accepted that Lp(a) assembly is a two-step process in which the initial non-covalent interaction between apo(a) and apo B-100 is mediated by the weak lysine binding sites present in kringle IV types 6, 7 and 8 of apo(a).	Lysine	170-176	lipoprotein(a)	Homo sapiens	34-39
6226655-12	1983	The sum of these interactions indicates that Glu-plasminogen binds to the Fragment D region of fibrinogen/fibrin through its low affinity binding site(s) and, as when lysine binds at these sites, the activation to Glu-plasmin is then accelerated.	Lysine	167-173	plasminogen	Bos taurus	49-56
27273574-3	2016	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, was originally proposed as a subunit of polycomb repressive complex 1 (PRC1) that could bind the tri-methylated lysine 27 of histone H3 (H3K27me3) established by the PRC2.	Lysine	200-206	like heterochromatin protein (LHP1)	Arabidopsis thaliana	16-46
27273574-3	2016	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, was originally proposed as a subunit of polycomb repressive complex 1 (PRC1) that could bind the tri-methylated lysine 27 of histone H3 (H3K27me3) established by the PRC2.	Lysine	200-206	like heterochromatin protein (LHP1)	Arabidopsis thaliana	48-52
27273574-3	2016	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, was originally proposed as a subunit of polycomb repressive complex 1 (PRC1) that could bind the tri-methylated lysine 27 of histone H3 (H3K27me3) established by the PRC2.	Lysine	200-206	like heterochromatin protein (LHP1)	Arabidopsis thaliana	69-86
11325856-4	2001	eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue.	Lysine	149-155	eukaryotic translation initiation factor 5A2	Homo sapiens	0-7
27797450-5	2016	SUMMARY: Background Using tissue factor pathway inhibitor (TFPI)-2 Kunitz domain1 (KD1), we obtained a bifunctional antifibrinolytic molecule (KD1L17R -KT ) with C-terminal lysine (kringle domain binding) and P2"-residue arginine (improved specificity towards plasmin).	Lysine	173-179	tissue factor pathway inhibitor 2	Mus musculus	26-66
6577469-4	1983	Experiments in which [3H]lysine was added to the perfusates showed that the apolipoprotein B that accumulated in VLDL was newly synthesized by the liver whereas the small amount of apolipoprotein B found in lipoproteins of higher density appeared to be washed out of extravascular spaces during perfusion.	Lysine	25-31	apolipoprotein B	Oryctolagus cuniculus	76-92
6577469-4	1983	Experiments in which [3H]lysine was added to the perfusates showed that the apolipoprotein B that accumulated in VLDL was newly synthesized by the liver whereas the small amount of apolipoprotein B found in lipoproteins of higher density appeared to be washed out of extravascular spaces during perfusion.	Lysine	25-31	apolipoprotein B	Oryctolagus cuniculus	181-197
11369207-12	2001	Glutamic acid substitution of the four lysine residues in the polybasic stretch at the COOH terminus of Ki-Ras completely abolishes the activation of Mn-SOD, although it does not inhibit ERK1/2-induced transcription.	Lysine	39-45	superoxide dismutase 2	Homo sapiens	150-156
6309520-0	1983	Enzymatic trimethylation of lysine-72 in cytochrome c.	Lysine	28-34	cytochrome c, somatic	Equus caballus	41-53
6309217-2	1983	The success of this procedure, which employs a matrix previously found ineffective with beef or yeast oxidase, is attributed to thorough dispersion of the enzyme with nonionic detergent and a low density of cross-linking between the lysine residues of cytochrome c and the cyanogen bromide activated Sepharose.	Lysine	233-239	cytochrome c, somatic	Equus caballus	252-264
27329046-0	2016	Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand.	Lysine	75-78	nuclear receptor subfamily 0, group B, member 1	Mus musculus	79-82
27439540-5	2016	In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain.	Lysine	17-20	brain derived neurotrophic factor	Mus musculus	88-121
11749178-2	2001	Fluorescent probes were used to detect that the membrane protein BR may act as a glutamine donor as well as a lysine donor for TGase.	Lysine	110-116	transglutaminase 1	Homo sapiens	127-132
26607633-7	2016	Our data show a disruption of energy and redox homeostasis associated to inflammation induced by QUIN in the striatum of Gcdh -/- mice submitted to a high Lys diet.	Lysine	155-158	glutaryl-Coenzyme A dehydrogenase	Mus musculus	121-125
7126601-4	1982	Biologically active tripeptides such as Met-Leu-Tyr (chemotactic factor), Gly-His-Lys (liver growth factor) and Thr-Val-leu central nervous system tripeptide) were hydrolyzed at rates 0.05-0.15-times that of Leu-Gly-Gly.	Lysine	82-85	myotrophin	Rattus norvegicus	93-106
11292199-5	2001	CPU cleaves off C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin.	Lysine	27-33	carboxypeptidase B2	Homo sapiens	0-3
6284736-3	1982	The fragment C-2 has now been selectively methylated with formaldehyde and sodium cyanoborohydride to give the epsilon-dimethylamino derivatives of Lys-30, 40, and 41 in 96-99% average yield.	Lysine	148-151	complement C2	Homo sapiens	13-16
6284736-5	1982	In contrast, dimethylation of the lysine residues of the C-1 fragment gave a derivative which did not form an active complex with unmethylated C-2.	Lysine	34-40	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	57-60
27595327-0	2016	Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.	Lysine	68-74	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	14-19
27595327-3	2016	Here we used aryl boronic acid carbonyl warheads to covalently target a noncatalytic lysine side chain, and generated to our knowledge the first reversible covalent inhibitors for Mcl-1, a protein-protein interaction (PPI) target that has proven difficult to inhibit via traditional medicinal chemistry strategies.	Lysine	85-91	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	180-185
27650450-7	2016	We identified an Arabidopsis (Arabidopsis thaliana) pex12 Glu-to-Lys missense allele that conferred severe peroxisomal defects, including impaired beta-oxidation, inefficient matrix protein import, and decreased growth.	Lysine	65-68	peroxin-12	Arabidopsis thaliana	52-57
27650450-12	2016	Future biochemical analyses will be needed to determine whether destabilization of the RING peroxin complex observed in pex12-1 stems from PEX4-dependent ubiquitination on the pex12-1 ectopic Lys residue.	Lysine	192-195	peroxin-12	Arabidopsis thaliana	176-181
11292199-5	2001	CPU cleaves off C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin.	Lysine	27-33	plasminogen	Homo sapiens	97-104
11292199-6	2001	Because these C-terminal lysine residues are important for upregulating the fibrinolytic rate, CPU thus slows down fibrinolysis.	Lysine	25-31	carboxypeptidase B2	Homo sapiens	95-98
11264375-6	2001	Two lysine residues at positions 175 and 180 were mapped as major alternative SUMO-1 conjugation sites in both cotransfected cells and an in vitro sumoylation assay and could be conjugated by SUMO-1 simultaneously.	Lysine	4-10	small ubiquitin like modifier 1	Homo sapiens	78-84
27459069-7	2016	Screening a panel of peptides with different acyl lysine modifications, we found that HDAC8 can catalyze the removal of acyl groups with 2-16 carbons from lysine 9 of the histone H3 peptide (H3K9).	Lysine	50-56	histone deacetylase 8	Homo sapiens	86-91
27459069-7	2016	Screening a panel of peptides with different acyl lysine modifications, we found that HDAC8 can catalyze the removal of acyl groups with 2-16 carbons from lysine 9 of the histone H3 peptide (H3K9).	Lysine	155-161	histone deacetylase 8	Homo sapiens	86-91
27459069-12	2016	This is the first report of a zinc-dependent HDAC with de-fatty-acylation activity, and identification of HDAC8 de-fatty-acylation targets will help to further understand the function of HDAC8 and protein lysine fatty acylation.	Lysine	205-211	histone deacetylase 8	Homo sapiens	106-111
7104366-9	1982	From the evidence presented it is concluded: (1) dialdehyde-ADP behaves as an affinity label of rabbit muscle pyruvate kinase; (2) the inactivator binds probably to lysine residues at or near the active site, forming morpholine-like structures, and (3) the enzyme possesses two modifiable groups essential for activity, the reaction of one of them being sufficient to cause total loss in activity.	Lysine	165-171	pyruvate kinase PKLR	Oryctolagus cuniculus	110-125
11264375-6	2001	Two lysine residues at positions 175 and 180 were mapped as major alternative SUMO-1 conjugation sites in both cotransfected cells and an in vitro sumoylation assay and could be conjugated by SUMO-1 simultaneously.	Lysine	4-10	small ubiquitin like modifier 1	Homo sapiens	192-198
11312612-10	2001	Thus, lysine decarboxylases such as p80 inhibit growth by removing lysine from mammalian cell culture media.	Lysine	6-12	coilin	Homo sapiens	36-39
6275898-1	1982	The kinetics of oxidation of horse cytochrome c and the trifluoromethylphenylcarbamylated lysine-13 derivative by cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1) were compared using both spectrophotometric and polarographic methods under different experimental conditions.	Lysine	90-96	cytochrome c, somatic	Equus caballus	114-126
6329685-1	1982	A peptide Tyr.Arg.Asp.Leu.Lys.Leu corresponding to the carboxy-terminal six amino acids of small-t antigen predicted from the DNA sequence of SV40 was synthesised, coupled to bovine serum albumin and to ovalbumin and used to raise antibody in rabbits.	Lysine	26-29	albumin	Oryctolagus cuniculus	182-195
27752143-1	2016	Acetylation of the lysine 40 of alpha-tubulin (K40) is a post-translational modification occurring in the lumen of microtubules (MTs) and is controlled by the alpha-tubulin acetyl-transferase alphaTAT1.	Lysine	19-25	alpha tubulin acetyltransferase 1	Homo sapiens	192-201
27531967-6	2016	Many of the 25 lysines present in DGAT2 appeared to be involved in promoting its degradation.	Lysine	15-22	diacylglycerol O-acyltransferase 2	Homo sapiens	34-39
11134025-5	2001	A distinct, Arg/Lys-rich N-terminal region targets CKA1 to the cell periphery.	Lysine	16-19	Choline Kinase A	Caenorhabditis elegans	51-55
27569210-3	2016	SMYD3-mediated dimethylation of H2A.Z.1 at lysine 101 (H2A.Z.1K101me2) increased stability by preventing binding to the removal chaperone ANP32E and facilitating its interaction with histone H3.	Lysine	43-49	H2A.Z variant histone 1	Homo sapiens	32-39
28090581-2	2016	Our study reveals an unexpected action of RNF8 in promoting cancer metastasis, cancer stem cell formation, and chemoresistance through the regulation of TWIST lysine 63 (K63)-linked ubiquitination, suggesting that RNF8 may serve as a new cancer prognosis marker and therapeutic target.	Lysine	159-165	ring finger protein 8	Homo sapiens	42-46
28090581-2	2016	Our study reveals an unexpected action of RNF8 in promoting cancer metastasis, cancer stem cell formation, and chemoresistance through the regulation of TWIST lysine 63 (K63)-linked ubiquitination, suggesting that RNF8 may serve as a new cancer prognosis marker and therapeutic target.	Lysine	159-165	ring finger protein 8	Homo sapiens	214-218
6297137-0	1982	Effect of chemical modification of a histidine and a lysine residue of pea seed nucleoside diphosphate kinase.	Lysine	53-59	cytidine/uridine monophosphate kinase 2	Homo sapiens	80-109
6297137-1	1982	Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase).	Lysine	41-47	cytidine/uridine monophosphate kinase 2	Homo sapiens	77-106
6297137-1	1982	Chemical modification of a histidine and lysine residue inactivates pea seed nucleoside diphosphate kinase (NDP kinase).	Lysine	41-47	cytidine/uridine monophosphate kinase 2	Homo sapiens	108-118
6297137-2	1982	Thus there seems to be a reactive lysine residue, at the active site of pea seed NDP kinase, in addition to the histidine residue phosphorylated by the substrate ATP as a consequence of the enzyme reaction.	Lysine	34-40	cytidine/uridine monophosphate kinase 2	Homo sapiens	81-91
6297138-0	1982	Effects of chemical modification of lysine, tyrosine and tryptophan residues in pea seed nucleoside diphosphate kinase and inhibition of the enzyme with antibodies.	Lysine	36-42	cytidine/uridine monophosphate kinase 2	Homo sapiens	89-118
11114303-4	2001	In the present communication we have identified the 61-kDa plasmin fragment as a novel four kringle-containing protein consisting of the amino acid sequence Lys(78)-Lys(468).	Lysine	157-160	plasminogen	Homo sapiens	59-66
6974731-4	1981	H1B extracted with 5% HClO4 along with H1A has a very similar amino acid composition and tryptic peptide map to H1o, a subfraction of lysine-rich histones found in nondividing mammalian cells.	Lysine	134-140	H1.5 linker histone, cluster member	Homo sapiens	0-3
27666593-4	2016	The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414.	Lysine	131-137	tripartite motif containing 14	Homo sapiens	17-23
27666593-4	2016	The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414.	Lysine	131-137	cyclic GMP-AMP synthase	Homo sapiens	50-54
27666593-4	2016	The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414.	Lysine	131-137	cyclic GMP-AMP synthase	Homo sapiens	123-127
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	Lysine	224-230	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	128-146
11114303-4	2001	In the present communication we have identified the 61-kDa plasmin fragment as a novel four kringle-containing protein consisting of the amino acid sequence Lys(78)-Lys(468).	Lysine	165-168	plasminogen	Homo sapiens	59-66
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	Lysine	224-230	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	297-300
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Lysine	126-134	interleukin 4 induced 1	Homo sapiens	52-72
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Lysine	126-134	interleukin 4 induced 1	Homo sapiens	74-77
27510653-3	2016	The results demonstrated that high doses of arginine increased IL-4, IL-10 and TNF-alpha secretion of T cells, while increasing concentrations of lysine increased IL-10 secretion and proliferative activity of the T cells.	Lysine	146-152	interleukin 10	Felis catus	163-168
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Lysine	126-134	interleukin 4 induced 1	Homo sapiens	216-219
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	59-67	interleukin 4 induced 1	Homo sapiens	129-132
6165589-0	1981	Effect of anti-Lyb3 antiserum on poly (L-glutamic acid, L-lysine)-induced B cell tolerance.	Lysine	56-65	B-lymphocyte antigen 3	Mus musculus	15-19
11319613-6	2001	The latter apoptosis was completely blocked by addition of L-lysine to the culture medium, which is the best substrate of AIP as LAO, indicating that decreased concentration of L-lysine in the culture medium by AIP-treatment induced apoptosis.	Lysine	177-185	interleukin 4 induced 1	Homo sapiens	129-132
11250042-12	2001	The 469 E/K polymorphism is in exon 6 and results in a change from glutamic acid to lysine in Ig-like domain 5 of ICAM-1, which is thought to affect interactions with LFA-1 and adhesion of B-cells.	Lysine	84-90	integrin subunit alpha L	Homo sapiens	167-172
6769116-6	1980	We conclude that the lysine residues in positions beta 66 and beta 95 are directly involved in the binding of cytochrome b5.	Lysine	21-27	cytochrome b5 type A	Homo sapiens	110-123
6769116-7	1980	The three-dimensional structure of hemoglobin suggests that the cytochrome b5-binding domain of hemoglobin is constituted by four lysine residues surrounding the heme crevice in both alpha and beta chains.	Lysine	130-136	cytochrome b5 type A	Homo sapiens	64-77
26386840-2	2016	Tissue transglutaminase (tTG) is a calcium-dependent enzyme that cross-links proteins forming a gamma-glutamyl-epsilon-lysine isopeptide bond.	Lysine	119-125	transglutaminase 2, C polypeptide	Mus musculus	0-23
26386840-2	2016	Tissue transglutaminase (tTG) is a calcium-dependent enzyme that cross-links proteins forming a gamma-glutamyl-epsilon-lysine isopeptide bond.	Lysine	119-125	transglutaminase 2, C polypeptide	Mus musculus	25-28
11263835-12	2001	Both lysine and glutamic acid induced (P = 0.001) acute release of prolactin, whereas an acute release of insulin was elicited (P = 0.002) only by lysine.	Lysine	147-153	INS	Equus caballus	106-113
27257062-2	2016	Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation.	Lysine	204-210	forkhead box A1	Homo sapiens	57-62
27257062-6	2016	TET1 thus co-occupies FOXA1-dependent enhancers and mediates local DNA demethylation and concomitant histone 3 lysine 4 methylation, further potentiating FOXA1 recruitment.	Lysine	111-117	tet methylcytosine dioxygenase 1	Homo sapiens	0-4
27257062-6	2016	TET1 thus co-occupies FOXA1-dependent enhancers and mediates local DNA demethylation and concomitant histone 3 lysine 4 methylation, further potentiating FOXA1 recruitment.	Lysine	111-117	forkhead box A1	Homo sapiens	22-27
27257062-6	2016	TET1 thus co-occupies FOXA1-dependent enhancers and mediates local DNA demethylation and concomitant histone 3 lysine 4 methylation, further potentiating FOXA1 recruitment.	Lysine	111-117	forkhead box A1	Homo sapiens	154-159
6783054-5	1980	In weanling pigs, both GOT and GPT exhibited significant negative quadratic relationship with dietary lysine levels and were also significantly influenced by the sex of the animals.	Lysine	102-108	alanine aminotransferase 1	Sus scrofa	31-34
11263835-14	2001	In the horse, aspartic acid, glutamic acid, and NMA seem to stimulate GH release; arginine and lysine seem to stimulate prolactin and insulin release; and NMA seems to stimulate LH and FSH release.	Lysine	95-101	INS	Equus caballus	134-141
7441383-7	1980	15N atom % excess in the lysine fraction of the hydrolysate of plasma protein was found in the range of 0.01-0.05% in a large number of cases of PNG subjects, and Japanese control of LPD, while it was not significantly detectable in Japanese controls of SPD.	Lysine	25-31	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	183-186
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Lysine	181-184	glutamate metabotropic receptor 1	Homo sapiens	17-23
229893-8	1979	This indicates that the interaction between the two proteins is best described as the sum of n complementary charge interactions, each involving a specific lysine on cytochrome c and a specific carboxyl group on cytochrome b5.	Lysine	156-162	cytochrome b5 type A	Homo sapiens	212-225
27729849-8	2016	Visual deprivation induced selective augmentation of histone H4 acetylation at lysine 16 in BLBP-positive cells.	Lysine	79-85	fatty acid binding protein 7, brain L homeolog	Xenopus laevis	92-96
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Lysine	181-184	glutamate metabotropic receptor 1	Homo sapiens	32-38
27695348-8	2016	Mechanistic studies revealed that HOTAIR modified the promoter of p53 and enhanced histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	94-100	HOX transcript antisense RNA	Homo sapiens	34-40
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Lysine	60-66	karyopherin (importin) alpha 1	Mus musculus	186-191
226162-6	1979	A semisynthetic peptide corresponding to residues 66 through 104 of cytochrome c was prepared by condensing the synthetic peptide 66--79 N-hydroxysuccinimide ester with t-butyloxycarbonyl (Lys,Tyr)80--104.	Lysine	189-192	cytochrome c, somatic	Equus caballus	68-80
11248282-6	2001	A second mutation characterised by a G(1344)--&gt;C transversion in exon VIII was detected in the proband resulting in a Lys(408)--&gt;Asn substitution.	Lysine	121-124	cytochrome c oxidase subunit 8A	Homo sapiens	73-77
27605042-1	2016	Pericentromeric heterochromatin (PCH) gives rise to highly dense chromatin sub-structures rich in the epigenetic mark corresponding to the trimethylated form of lysine 9 of histone H3 (H3K9me3) and in heterochromatin protein 1alpha (HP1alpha), which regulate genome expression and stability.	Lysine	161-167	chromobox 5	Mus musculus	201-231
27605042-1	2016	Pericentromeric heterochromatin (PCH) gives rise to highly dense chromatin sub-structures rich in the epigenetic mark corresponding to the trimethylated form of lysine 9 of histone H3 (H3K9me3) and in heterochromatin protein 1alpha (HP1alpha), which regulate genome expression and stability.	Lysine	161-167	chromobox 5	Mus musculus	233-241
11106639-0	2001	Crucial role of the high-loop lysine for the catalytic activity of arginyl-tRNA synthetase.	Lysine	30-36	arginyl-tRNA synthetase 1	Homo sapiens	67-90
27256581-3	2016	By applying a penalization method, we identified two genes FGF8 and MDGA2 with significant effects on lysine and cis-4-decenoylcarnitine, respectively, using Delta-AIC and likelihood ratio test statistics.	Lysine	102-108	fibroblast growth factor 8	Homo sapiens	59-63
218922-0	1979	Differential modification of specific lysine residues in the two kinds of subfragment-1 of myosin with  2, 4, 6-trinitrobenzenesulfonate.	Lysine	38-44	myosin heavy chain 14	Homo sapiens	91-97
11161218-2	2001	Here, we present the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [PtdIns(4,5)P2] via a lysine-rich motif.	Lysine	136-142	phosphatidylinositol binding clathrin assembly protein	Homo sapiens	61-65
371981-0	1979	Reading of the lysine codons in the MS 2 coat protein cistron during protein synthesis in vitro.	Lysine	15-21	MS2	Homo sapiens	36-40
27373678-1	2016	Suppressor of variegation 3-9 homolog 1 (Suv39h1) is a histone methyltransferase that trimethylates lysine 9 of histone H3 (H3K9me3), which results in gene silencing.	Lysine	100-106	suppressor of variegation 3-9 1	Mus musculus	0-39
27373678-1	2016	Suppressor of variegation 3-9 homolog 1 (Suv39h1) is a histone methyltransferase that trimethylates lysine 9 of histone H3 (H3K9me3), which results in gene silencing.	Lysine	100-106	suppressor of variegation 3-9 1	Mus musculus	41-48
11168397-6	2001	Changing the His6 residue of alpha-MSH-ND to Gln or Lys markedly decreased CRE-mediated luciferase activity for MC3R compared with MC4R.	Lysine	52-55	melanocortin 3 receptor	Homo sapiens	112-116
27550047-1	2016	BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3).	Lysine	273-279	HOX transcript antisense RNA	Homo sapiens	34-73
27550047-1	2016	BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3).	Lysine	273-279	HOX transcript antisense RNA	Homo sapiens	75-81
457426-0	1979	Hb J Lome beta 59 (E3) Lys is replaced by Asn associated with HPFH in a Togolese family.	Lysine	23-26	HBFQTL2	Homo sapiens	62-66
11244310-6	2001	Early treatment with lysine prevented the rise in glycosylated HbA(1) (normal 6.98 +/- 0.71% vs. diabetic - early treatment - 7.78 +/- 1.50%; p = NS), reduced glycosylation of GBM collagen by 86%, and significantly improved albuminuria.	Lysine	21-27	hemoglobin alpha, adult chain 1	Rattus norvegicus	63-69
736888-13	1978	By treatment of inactivated phosphorylase b with carboxypeptidase B, it was shown that the intestinal muscle proteinase had cleaved approximately 3 -Lys-X and 3 -Arg-X bonds in the polypeptide.	Lysine	149-152	carboxypeptidase B1	Rattus norvegicus	49-67
26700226-3	2016	The lysine residue at position 40 (K40) of alpha-tubulin is an important site for acetylation, and this site is acetylated in the cilium.	Lysine	4-10	tubulin alpha 1b	Homo sapiens	43-56
11237259-3	2001	Lysyl oxidase from P. pastoris has a similar substrate specificity to the mammalian enzyme (both have been shown to oxidize peptidyl lysine residues) and is 30% identical to the human kidney diamine oxidase (the highest of any non-mammalian source).	Lysine	133-139	amine oxidase copper containing 1	Homo sapiens	191-206
27454931-6	2016	Using single-molecule measurements and biochemical assays we demonstrated that HDAC6 catalytic domain 2 deacetylated alpha-tubulin lysine 40 in the lumen of microtubules, but that its preferred substrate was unpolymerized tubulin.	Lysine	131-137	histone deacetylase 6	Danio rerio	79-84
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Lysine	36-39	POU class 5 homeobox 1	Homo sapiens	165-169
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Lysine	77-80	lysozyme C-like	Oryctolagus cuniculus	113-121
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Lysine	77-80	lysozyme C-like	Oryctolagus cuniculus	284-292
26379-2	1978	The rate of cross-linking myosin heads to the thick filament surface decreases significantly over a narrow pH range (7.4--8.0) despite the fact that the rate of the chemical reaction (amidination of lysine side chains) shows a positive pH dependence.	Lysine	199-205	myosin heavy chain 14	Homo sapiens	26-32
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Lysine	129-132	POU class 5 homeobox 1	Homo sapiens	165-169
27369080-5	2016	Thus, we conclude that Oct4/Lys-156-modulated Oct4/Sox2 interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals.	Lysine	28-31	POU class 5 homeobox 1	Homo sapiens	23-27
27369080-5	2016	Thus, we conclude that Oct4/Lys-156-modulated Oct4/Sox2 interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals.	Lysine	28-31	POU class 5 homeobox 1	Homo sapiens	46-50
11112693-5	2001	A bipartite basic nuclear localization signal between amino acids 539-556 of Ku70 was observed to be required for nuclear import of full-length Ku70 monomer, while a short Ku80 motif of four amino acids from 565-568 containing three lysines was required for the nuclear import of full-length Ku80.	Lysine	233-240	X-ray repair cross complementing 5	Homo sapiens	172-176
27402839-0	2016	High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.	Lysine	190-197	LDL receptor related protein associated protein 1	Homo sapiens	29-56
27402839-5	2016	Studies on the interaction of the RAP third domain with LRP1 reveal critical contributions by lysine 256 and lysine 270 for this interaction.	Lysine	94-100	LDL receptor related protein associated protein 1	Homo sapiens	34-37
632257-1	1978	Lactose has been coupled to the lysine residues of the cross-linked dimer of bovine pancreatic ribonuclease A by reductive amination with cyanoborohydride.	Lysine	32-38	ribonuclease	Saccharomyces cerevisiae S288C	95-107
11118214-4	2000	P/CAF-mediated acetylation, which mapped to a lysine-rich motif in the loop region, increased TAL1 binding to DNA while selectively inhibiting its interaction with the transcriptional co-repressor mSin3A.	Lysine	46-52	lysine acetyltransferase 2B	Homo sapiens	0-5
632257-2	1978	Derivatives of ribonuclease dimer that contained up to 10 Nepsilon-1-(1-deoxylactitolyl)-lysine residues per molecule had greater than 75% of the enzymic activity of the unmodified enzyme toward yeast RNA.	Lysine	89-95	ribonuclease	Saccharomyces cerevisiae S288C	15-27
27538435-3	2016	RESULTS: We report here the localization of the ubiquitinated and phosphorylated active form of TBK1 to the Golgi apparatus after the stimulation of RIG-I-like receptors (RLRs) or Toll-like receptor-3 (TLR3), due to TBK1 K63-linked ubiquitination on lysine residues 30 and 401.	Lysine	250-256	TANK binding kinase 1	Homo sapiens	96-100
27540854-4	2016	They elegantly demonstrate that DNA methylation and transcriptional activation at the HDAC9 promoter by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events during host defense.	Lysine	123-129	TANK binding kinase 1	Homo sapiens	147-151
21085-2	1977	gamma-Glutamyl transpeptidase activity was detected in rat ascites tumor cells (LY-5) suspended in Hanks" balanced saline solution using L-gamma-glutamyl-p-nitroanilide as a substrate.	Lysine	80-82	gamma-glutamyltransferase 1	Rattus norvegicus	0-29
11106495-8	2000	Introduction of Lys at P(1), in place of Arg in R(4)R(1)-eglin reduced affinity only approximately 3-fold for Kex2 but 15-fold for furin.	Lysine	16-19	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
849484-3	1977	Thus, the unique specificity for heparin in the anticoagulation system (which involves two or more lysine residues on the antithrombin molecule) is not paralleled by the findings with the basic homopolymers.	Lysine	99-105	serpin family C member 1	Homo sapiens	122-134
27339900-7	2016	We also show, by constructing lysine-to-arginine mutants of rat AANAT, that its degradation is mediated by polyubiquitylation of its Lys residue(s).	Lysine	30-36	aralkylamine N-acetyltransferase	Rattus norvegicus	64-69
27339900-7	2016	We also show, by constructing lysine-to-arginine mutants of rat AANAT, that its degradation is mediated by polyubiquitylation of its Lys residue(s).	Lysine	133-136	aralkylamine N-acetyltransferase	Rattus norvegicus	64-69
11106495-11	2000	However, substitution of Lys at P(2) in place of Thr(44) resulted in eglin variants that inhibited both Kex2 and furin but which were eventually cleaved (temporary inhibition).	Lysine	25-28	furin, paired basic amino acid cleaving enzyme	Homo sapiens	113-118
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	PML nuclear body scaffold	Homo sapiens	96-126
11080476-4	2000	The site of acetylation of Tat was mapped to the double-lysine motif in a highly conserved region, (49)RKKRRQ(54), of the basic RNA-binding motif of Tat.	Lysine	56-62	tyrosine aminotransferase	Homo sapiens	27-30
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	PML nuclear body scaffold	Homo sapiens	128-131
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	PML nuclear body scaffold	Homo sapiens	165-168
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	36-39	E3 ubiquitin-protein ligase RNF4	Mandrillus leucophaeus	116-120
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	92-95	E3 ubiquitin-protein ligase RNF4	Mandrillus leucophaeus	116-120
27462807-4	2016	53BP1 binds specifically to H2AK15ub-containing nucleosomes through a peptide segment termed the ubiquitination-dependent recruitment motif (UDR), which requires the simultaneous engagement of histone H4 lysine 20 dimethylation (H4K20me2) by its tandem Tudor domain.	Lysine	204-210	tumor protein p53 binding protein 1	Homo sapiens	0-5
16659859-8	1977	Amino acids or amino acid analogues added singly to the induction medium have a similar effect: i.e. when the induction of nitrate reductase is inhibited in the root tips (lysine, canavanine, azaserine, azetidine-2-carboxylic acid, dl-4-azaleucine, asparagine, and glutamine), that inhibition is more severe in mature root sections.	Lysine	172-178	nitrate reductase [NADH] 1	Zea mays	123-140
197035-3	1977	A solution synthesis of Z-Gly-Thr-Lys (Tfa)-Met-Ile-Phe-Ala-Gly-Ile-Lys (Tfa)-Lys (Tfa)-NHNH-Boc corresponding to the sequence 77-87 of horse heart cytochrome c is described.	Lysine	34-37	cytochrome c, somatic	Equus caballus	148-160
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Lysine	109-112	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Lysine	109-112	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
27311481-1	2016	Deacetylation of alpha-tubulin at lysine 40 is catalyzed by two enzymes, the NAD-dependent deacetylase SIRT2 and the NAD-independent deacetylase HDAC6, in apparently redundant reactions.	Lysine	34-40	sirtuin 2	Homo sapiens	103-108
11080476-4	2000	The site of acetylation of Tat was mapped to the double-lysine motif in a highly conserved region, (49)RKKRRQ(54), of the basic RNA-binding motif of Tat.	Lysine	56-62	tyrosine aminotransferase	Homo sapiens	149-152
11063570-9	2000	These results indicate that the AE1 binding site is located within the first 17 residues of CAII, and that the interaction is mediated by electrostatic interactions involving histidine and/or lysine residues.	Lysine	192-198	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	32-35
27303024-4	2016	The recombinant LcL/ODC preferentially catalyzed the decarboxylation of l-Lys over l-ornithine (l-Orn) by about 5 times.	Lysine	72-77	ornithine decarboxylase-like	Nicotiana tabacum	20-23
11060344-6	2000	To be recognized by Pex5p, however, the preceding lysine residue is critical.	Lysine	50-56	peroxisomal biogenesis factor 5	Homo sapiens	20-25
11046145-4	2000	Interestingly, CBP and PCAF acetylate CIITA at lysine residues within a nuclear localization signal.	Lysine	47-53	lysine acetyltransferase 2B	Homo sapiens	23-27
187601-10	1976	The COOH-terminal amino acid of P-450LM2 is arginine, as shown by carboxypeptidase treatment, whereas that of P-450LM4 is lysine.	Lysine	122-128	cytochrome P450 1A2	Oryctolagus cuniculus	110-118
27055146-6	2016	For example, EZH2 somatic mutations drive silencing of bivalent gene promoters through histone 3 lysine 27 trimethylation, whereas KMT2D (MLL2) mutations disrupt specific sets of enhancers through depletion of histone 3 lysine 4 mono and dimethylation (H3K4me1/me2).	Lysine	220-226	lysine methyltransferase 2D	Homo sapiens	131-136
11046145-6	2000	The shuttling behavior and activity of the protein are regulated by acetylation: overexpression of PCAF or inhibition of cellular deacetylases by trichostatin A increases the nuclear accumulation of CIITA in a manner determined by the presence of the acetylation target lysines.	Lysine	270-277	lysine acetyltransferase 2B	Homo sapiens	99-103
27055146-6	2016	For example, EZH2 somatic mutations drive silencing of bivalent gene promoters through histone 3 lysine 27 trimethylation, whereas KMT2D (MLL2) mutations disrupt specific sets of enhancers through depletion of histone 3 lysine 4 mono and dimethylation (H3K4me1/me2).	Lysine	220-226	lysine methyltransferase 2D	Homo sapiens	138-142
11091223-5	2000	The addition of poly-L-lysine or LipofectAmine increased the percentage of transduced cells at an MOI of 500 (CD1a+/AP+ cells = 85 +/- 3% and 80 +/- 2% respectively).	Lysine	16-29	CD1a molecule	Homo sapiens	110-114
27259240-4	2016	Mixed-lineage leukemia (MLL), a histone methyltransferase, was upregulated, leading to increased trimethylation of histone H3 lysine 4, while G9a was downregulated, leading to decreased dimethylation of histone H3 lysine 9. siRNA-mediated MLL knockdown decreased levels of Nrf2 and HO-1 to a greater extent than did silencing HAT1.	Lysine	126-132	lysine methyltransferase 2A	Homo sapiens	24-27
27259240-4	2016	Mixed-lineage leukemia (MLL), a histone methyltransferase, was upregulated, leading to increased trimethylation of histone H3 lysine 4, while G9a was downregulated, leading to decreased dimethylation of histone H3 lysine 9. siRNA-mediated MLL knockdown decreased levels of Nrf2 and HO-1 to a greater extent than did silencing HAT1.	Lysine	214-220	lysine methyltransferase 2A	Homo sapiens	24-27
1068692-4	1976	Lysine-rich (F1) histones showed lower contents of Cr2+, Sb2+ and Co2+, whereas arginine-rich (F3) histones had significantly higher contents of these trace metals.	Lysine	0-6	complement C2	Homo sapiens	66-69
11091223-6	2000	Polycations made it possible to reduce the amounts of viral particles, with high efficiency of transduction being achieved at a MOI of 100 with 10 microg/ml poly-L-lysine (CD1a+/AP+: 68 +/- 9%) or 30 microg/ml LipofectAmine (CD1a+/AP+: 60 +/- 7%).	Lysine	157-170	CD1a molecule	Homo sapiens	172-176
952873-6	1976	Galactosyltransferase was inactivated with a [3H]UDP derivative and the predominant labeled peptide, from thermolysin digestion, isolated and characterized as: Ser-Gly-Lys-UDP.	Lysine	168-171	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	0-21
27143358-6	2016	Consistent with a role of CKII in FACT and PAF-C function, we show that decreased CKII function in vivo results in decreased levels of histone H2B lysine 123 monoubiquitylation, a modification dependent on FACT and PAF-C. Taken together, our results define a coordinated role of CKII and FACT in the regulation of RNA polymerase II transcription through chromatin via phosphorylation of PAF-C.	Lysine	147-153	casein kinase 2 alpha 1	Homo sapiens	82-86
27143358-6	2016	Consistent with a role of CKII in FACT and PAF-C function, we show that decreased CKII function in vivo results in decreased levels of histone H2B lysine 123 monoubiquitylation, a modification dependent on FACT and PAF-C. Taken together, our results define a coordinated role of CKII and FACT in the regulation of RNA polymerase II transcription through chromatin via phosphorylation of PAF-C.	Lysine	147-153	casein kinase 2 alpha 1	Homo sapiens	82-86
10913438-4	2000	PLCbeta(1) exists as two polypeptides of 150 and 140 kDa generated from a single gene by alternative RNA splicing, both of them containing in the COOH-terminal tail a cluster of lysine residues responsible for nuclear localization.	Lysine	178-184	phospholipase C beta 1	Homo sapiens	0-9
27129219-7	2016	HBP1-mediated repression of EZH2 through Wnt/beta-catenin signaling decreased the level of trimethylation of histone H3 at lysine 27 of overall and specific histone on the p21 promoter, resulting in p21 transactivation.	Lysine	123-129	HMG-box transcription factor 1	Homo sapiens	0-4
27129219-7	2016	HBP1-mediated repression of EZH2 through Wnt/beta-catenin signaling decreased the level of trimethylation of histone H3 at lysine 27 of overall and specific histone on the p21 promoter, resulting in p21 transactivation.	Lysine	123-129	catenin beta 1	Homo sapiens	45-57
129327-17	1976	The homologues with either lysine or arginine in the P1 position are equally good inhibitors of trypsin, plasmin and kallikrein.	Lysine	27-33	plasminogen	Bos taurus	105-112
27129283-7	2016	On the molecular level, IkappaBzeta directly activated the Il10 promoter at a proximal kappaB site and was required for the transcription-enhancing trimethylation of histone 3 at lysine 4.	Lysine	179-185	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	Mus musculus	24-35
10889187-8	2000	Competitive experiments carried out with 6-aminohexanoic acid and kringle proteolytic fragments identified the lysine-binding site domains of plasmin as the RG1192 binding sites.	Lysine	111-117	plasminogen	Homo sapiens	142-149
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	vimentin	Homo sapiens	68-76
27056598-1	2016	Lysine methyltransferases G9a and GLP (G9a-like protein) are highly homologous and form functional heterodimeric complexes that establish mono- and dimethylation on histone H3 lysine 9 (H3K9me1, H3K9me2) in euchromatin.	Lysine	176-182	euchromatic histone lysine methyltransferase 1	Homo sapiens	34-37
10970779-8	2000	In conclusion, charge neutralization of Lys-84 and Arg-349 in NaDC-1 affects succinate handling, suggesting that these residues might have roles in substrate binding.	Lysine	40-43	solute carrier family 13 member 2L homeolog	Xenopus laevis	62-68
27056598-1	2016	Lysine methyltransferases G9a and GLP (G9a-like protein) are highly homologous and form functional heterodimeric complexes that establish mono- and dimethylation on histone H3 lysine 9 (H3K9me1, H3K9me2) in euchromatin.	Lysine	176-182	euchromatic histone lysine methyltransferase 1	Homo sapiens	39-55
27256596-4	2016	Here we show that Tbx1 positively regulates monomethylation of histone 3 lysine 4 (H3K4me1) through interaction with and recruitment of histone methyltransferases.	Lysine	73-79	T-box 1	Mus musculus	18-22
27210755-5	2016	Site-directed mutagenesis established that the size of nanoclusters is controlled by transmembrane amino acid 233, a lysine in KIR2DS1.	Lysine	117-123	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1	Homo sapiens	127-134
33754480-4	2021	In this work, we describe how we designed a novel cationic nonapeptide, containing only leucine and two lysine residues, with potent anti-MRSA activity and a rapid bactericidal mode of action.	Lysine	104-110	solute carrier family 9 member A6	Homo sapiens	138-142
33559894-8	2021	Preceding TNFalpha expression, we detected Phosphoserine 536 and acetylated lysine 310 of RelA after 2 hours exposure with P. gingivalis.	Lysine	76-82	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	90-94
34058195-5	2021	Within LRP1 CR-clusters II and IV, we identified multiple sites comprised of adjacent CR-doublets, which provide alternative bivalent binding combinations with specific pairs of lysines on RAP.	Lysine	178-185	LDL receptor related protein associated protein 1	Homo sapiens	189-192
10974350-3	2000	The interaction of plasminogen was significantly (&gt;90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.	Lysine	72-78	plasminogen	Homo sapiens	19-30
34058195-6	2021	Mutational analysis of these lysines within each of isolated RAP D1/D2 and D3 domains having high-affinity to LRP1, and of conserved tryptophans on selected CR-doublets of LRP1, as well as in silico docking of a model LRP1 CR-triplet with RAP indicated a universal role for these residues in interaction of RAP and LRP1.	Lysine	29-36	LDL receptor related protein associated protein 1	Homo sapiens	61-64
27075367-2	2016	SET and MYND domain containing protein 2 (SMYD2) is a catalytic SET domain containing methyltransferase reported to monomethylate lysine residues on histone and nonhistone proteins.	Lysine	130-136	SET and MYND domain containing 2	Homo sapiens	42-47
10974350-6	2000	Using carboxypeptidase B digestion, the plasminogen-binding site of antithrombin III was localized to the carboxy-terminus lysine of the anticoagulant protein.	Lysine	123-129	plasminogen	Homo sapiens	40-51
10974350-7	2000	Tissue plasminogen activator also interacted with antithrombin III in a time- and concentration-dependent manner and its binding was also significantly (&gt;90%) inhibited by lysine.	Lysine	175-181	plasminogen	Homo sapiens	7-18
33998791-2	2021	Histone deacetylase 8 (HDAC8), which is proved to be involved in carcinogenesis, is an enzyme associated with the chromatin for post-translational deacetylation of acetylated lysine.	Lysine	175-181	histone deacetylase 8	Homo sapiens	0-21
10978616-5	2000	The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg-&gt;Arg-Arg-&gt;Met-&gt;Leu-&gt;Lys-&gt;Phe-&gt;Lys-Ala-&gt;Tyr-&gt;Ala-MCAs.	Lysine	103-106	alanyl aminopeptidase, membrane	Homo sapiens	39-44
33998791-2	2021	Histone deacetylase 8 (HDAC8), which is proved to be involved in carcinogenesis, is an enzyme associated with the chromatin for post-translational deacetylation of acetylated lysine.	Lysine	175-181	histone deacetylase 8	Homo sapiens	23-28
34032265-4	2021	WD40 repeat protein 5 (WDR5) interacts with all members of human SET1/MLL methyltransferases, which regulate methylation of the histone 3 lysine 4 (H3K4).	Lysine	138-144	lysine methyltransferase 2A	Homo sapiens	70-73
32262970-1	2016	We report the design, synthesis and structure-property investigation of a new perylene diimide material (PDI-Lys) bearing lysine end substituents.	Lysine	122-128	peptidyl arginine deiminase 1	Homo sapiens	105-108
32262970-3	2016	With the aim of evaluating the potential of PDI-Lys as a biocompatible and functional neural interface for organic bioelectronic applications, its electrochemical impedance as well as the adhesion and viability properties of primary neurons on the PDI-Lys films were studied.	Lysine	48-51	peptidyl arginine deiminase 1	Homo sapiens	44-47
32262970-4	2016	By combining theoretical calculations and electrical measurements we show that due to conversion between neutral and zwitterionic anions, the PDI-Lys film conductivity increased significantly upon passing from air to an inert atmosphere, reaching a maximum value of 6.3 S m-1.	Lysine	146-149	peptidyl arginine deiminase 1	Homo sapiens	142-145
34006870-5	2021	PLK1 transcript levels are shown to be regulated by an unmutated lysine methyl-transferase (KMT2A) resulting in increased promoter monomethylation of lysine 4 of histone 3.	Lysine	65-71	lysine methyltransferase 2A	Homo sapiens	92-97
10978616-5	2000	The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg-&gt;Arg-Arg-&gt;Met-&gt;Leu-&gt;Lys-&gt;Phe-&gt;Lys-Ala-&gt;Tyr-&gt;Ala-MCAs.	Lysine	119-122	alanyl aminopeptidase, membrane	Homo sapiens	39-44
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	Lysine	106-112	dicer 1, ribonuclease III	Homo sapiens	30-35
11034564-2	2000	NA2M differs in a single nucleotide (193G--&gt;A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu--&gt;Lys).	Lysine	116-119	Fc gamma receptor IIIb	Homo sapiens	55-61
26896748-6	2016	The acetylation of histone 3 at lysine residues 56 (H3K56), H3K14, H3K9, and H3K27, putative substrates of SIRT2 and SIRT6, was increased by maternal diabetes in vivo or high glucose in vitro, and these increases were blocked by SOD1 over-expression or tempol treatment.	Lysine	32-38	sirtuin 2	Mus musculus	107-112
33963283-6	2021	An epigenetic ASM switching induces C allele hypermethylation and then recruits repressive Polycomb repressive complex 2 (PRC2), reinforces trimethylation of lysine 27 on histone 3 and inhibits its transcriptional activity, thus leading to downregulation of EIPR1 in schizophrenia.	Lysine	158-164	EARP complex and GARP complex interacting protein 1	Homo sapiens	258-263
10764765-6	2000	Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding and identify by site-directed mutagenesis several key residues (Lys(1292), Leu(1298), Arg(1299), Arg(1300), Gln(1301), and Ser(1303)).	Lysine	164-167	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	63-67
33975152-9	2021	A salient finding of this study was identification of two new variants in IRS-1 gene, representing G > A (codon 1102) encoding Glu > Lys and a deletion of (A) at codon 658 in morbidly obese subjects with insulin resistance.	Lysine	133-136	insulin receptor substrate 1	Homo sapiens	74-79
27049934-4	2016	An efficient SERS nanoprobe has been constructed using gold nanoparticles as SERS substrate, and the TPE-In as the Raman reporter, which conjugated with a specific peptide substrate, Cys-Ser-Lys-Leu-Gln-OH, well-known for the recognition of prostate-specific antigen (PSA).	Lysine	191-194	kallikrein related peptidase 3	Homo sapiens	241-272
11003134-2	2000	In the present report, a linear analogue and a series of cyclic semi-mimetic peptides were designed and synthesized based on the human myelin basic protein (MBP(87-99)) epitope (Val87-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro90) and on Copolymer I (a mixture of random polymers of Ala, Gln, Lys and Tyr used to treat MS).	Lysine	196-199	myelin basic protein	Homo sapiens	135-155
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	107-110	zinc finger CW-type and PWWP domain containing 2	Homo sapiens	38-44
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	107-110	MORC family CW-type zinc finger 3	Homo sapiens	49-56
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	196-199	zinc finger CW-type and PWWP domain containing 2	Homo sapiens	38-44
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	196-199	MORC family CW-type zinc finger 3	Homo sapiens	49-56
33786615-7	2021	Decreased MUC22 expression in NSCLC cell lines was restored upon treatment with epigenetic modifiers 5-aza-2"-deoxycytidine (5-Aza) or trichostatin A (TSA), accompanied by reduction in global protein level of histone deacetylase 1 (HDAC1) but increased enrichment of histone H3 lysine 9 acetylation (H3K9ac) specifically in the MUC22 promoter in the SK-MES-1 cell line.	Lysine	278-284	mucin 22	Homo sapiens	10-15
27098497-4	2016	Here we report that in Schizosaccharomyces pombe a conserved DDB1-CUL4-associated factor (DCAF), Wdr70, is recruited to DSBs as part of the Cullin4-DDB1 ubiquitin ligase (CRL4(Wdr70)) and stimulates distal H2B lysine 119 mono-ubiquitination (uH2B).	Lysine	210-216	interleukin 17 receptor B	Homo sapiens	171-175
11003134-2	2000	In the present report, a linear analogue and a series of cyclic semi-mimetic peptides were designed and synthesized based on the human myelin basic protein (MBP(87-99)) epitope (Val87-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro90) and on Copolymer I (a mixture of random polymers of Ala, Gln, Lys and Tyr used to treat MS).	Lysine	196-199	myelin basic protein	Homo sapiens	157-160
10891493-6	2000	PCAF binds to the E1B 55-kDa protein and to a region near the C terminus of p53 encompassing Lys-320, the specific PCAF acetylation site.	Lysine	93-96	lysine acetyltransferase 2B	Homo sapiens	0-4
26726734-0	2016	Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on alpha-Synuclein Aggregation and Toxicity.	Lysine	54-60	synuclein alpha	Homo sapiens	161-176
33891828-7	2021	The increased Trpm7 expression coincided with the reduction in CpG site-specific methylation and tri-methylation of histone 3 (H3) lysine (K) 27 (H3K27M3), and the increase in acetylation of H3K27 (H3K27Ac) and tri-methylation of H3K4 (H3K4M3) at the Trpm7 promoter.	Lysine	131-137	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	14-19
10891493-6	2000	PCAF binds to the E1B 55-kDa protein and to a region near the C terminus of p53 encompassing Lys-320, the specific PCAF acetylation site.	Lysine	93-96	lysine acetyltransferase 2B	Homo sapiens	115-119
10935550-7	2000	Substitution of L124 in the hbeta2-AR with arginine, lysine, or alanine resulted in constitutive activation as evidenced by increased basal levels of cAMP that could be attenuated by an inverse agonist.	Lysine	53-59	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
33924051-4	2021	We found that a heterozygous tnnt2a mutation deleting Arginine at position 94 and Lysine at position 95 of TnT causes progressive cardiac structural changes resulting in heart failure.	Lysine	82-88	troponin T1, slow skeletal type	Homo sapiens	107-110
26917724-7	2016	Nerve injury consistently increased the enrichment of the G9a product histone 3 at lysine 9 dimethylation in the promoter of Oprm1 in the DRG.	Lysine	83-89	opioid receptor, mu 1	Rattus norvegicus	125-130
26929406-9	2016	Reduction in acetylation of histone H3 Lys-27 accompanies loss of FoxO1 and FoxA1/A2 binding.	Lysine	39-42	forkhead box A1	Homo sapiens	76-81
10951564-6	2000	Mutational analysis demonstrated that lysine 265 and/or arginine 266 were required for nuclear import of ETO, but that the surrounding basic residues were not critical.	Lysine	38-44	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	105-108
25526092-5	2016	We show here with gene expression screening of epigenetic enzymes that the highly expressed H3 methyltransferase disruptor of telomeric silencing 1-like (DOT1L) drives a transitional pattern of di-methylation on H3 lysine 79 (H3K79) in CMs at different stages of differentiation in vitro and in vivo.	Lysine	215-221	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	154-159
33463886-0	2021	An Unsual Cys-Glu-Lys Catalytic Triad is Responsible for the Catalytic Mechanism of the Nitrilase Superfamily: a QM/MM study on Nit2.	Lysine	18-21	nitrilase family member 2	Homo sapiens	128-132
33875777-3	2021	LH2 hydroxylates lysine (Lys) residues on fibrillar collagen"s amino- and carboxy-terminal telopeptides to create stable collagen cross-links.	Lysine	17-23	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-3
10951567-5	2000	Mutating W342 to aspartate (D), lysine (K) or histidine (H) also inactivated c-Raf whether assayed as a purified immunoprecipitate or when recruited to the plasma membrane.	Lysine	32-38	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	77-82
33875777-3	2021	LH2 hydroxylates lysine (Lys) residues on fibrillar collagen"s amino- and carboxy-terminal telopeptides to create stable collagen cross-links.	Lysine	25-28	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-3
26999603-1	2016	The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally permissive chromatin.	Lysine	131-137	lysine (K)-specific demethylase 6A	Mus musculus	25-48
10777508-6	2000	PCAF-catalyzed acetylation of the substrate H3-20 was shown to be specific for Lys-14, analogous to its behavior with the full-length histone H3 protein.	Lysine	79-82	lysine acetyltransferase 2B	Homo sapiens	0-4
26999603-1	2016	The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally permissive chromatin.	Lysine	131-137	lysine (K)-specific demethylase 6A	Mus musculus	64-69
27123477-3	2016	EHMT1 encodes a histone H3 methyltransferase at position Lys-9 (H3K9).	Lysine	57-60	euchromatic histone lysine methyltransferase 1	Homo sapiens	0-5
33852868-5	2021	During chronic lymphocytic choriomeningitis virus (LCMV) infection in mice, UTX binds to enhancers and transcription start sites of effector genes, allowing for improved cytotoxic T lymphocyte (CTL)-mediated protection, independent of its trimethylation of histone 3 lysine 27 (H3K27me3) demethylase activity.	Lysine	267-273	lysine (K)-specific demethylase 6A	Mus musculus	76-79
10892746-2	2000	We demonstrate that Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 self-ubiquitination.	Lysine	67-70	small ubiquitin like modifier 1	Homo sapiens	44-50
33846303-5	2021	Mechanistically, TRIM39 interacts with Rab7 and promotes its activity via inhibiting its ubiquitination at lysine 191 residue.	Lysine	107-113	tripartite motif containing 39	Homo sapiens	17-23
10828064-0	2000	WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.	Lysine	78-84	WNK lysine deficient protein kinase 1	Homo sapiens	0-4
33685627-3	2021	Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22).	Lysine	53-59	ubiquitin specific peptidase 22	Homo sapiens	146-177
33685627-3	2021	Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22).	Lysine	53-59	ubiquitin specific peptidase 22	Homo sapiens	179-184
26690800-0	2016	Lysines, Achilles" heel in alpha-synuclein conversion to a deadly neuronal endotoxin.	Lysine	0-7	synuclein alpha	Homo sapiens	27-42
26690800-2	2016	The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains.	Lysine	59-66	synuclein alpha	Homo sapiens	16-31
26717101-1	2016	The tumor suppressor, cylindromatosis (CYLD), is a negative regulator of NF-kappaB signaling by removing lysine 63-linked ubiquitin chains from multiple NF-kappaB signaling components, including TRAF2, TRAF6, and NEMO.	Lysine	105-111	TNF receptor associated factor 6	Homo sapiens	202-207
26717101-1	2016	The tumor suppressor, cylindromatosis (CYLD), is a negative regulator of NF-kappaB signaling by removing lysine 63-linked ubiquitin chains from multiple NF-kappaB signaling components, including TRAF2, TRAF6, and NEMO.	Lysine	105-111	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	213-217
10828064-7	2000	The demonstration of activity was striking because WNK1, and its homologs in other organisms lack the invariant catalytic lysine in subdomain II of protein kinases that is crucial for binding to ATP.	Lysine	122-128	WNK lysine deficient protein kinase 1	Homo sapiens	51-55
10828064-8	2000	A model of WNK1 using the structure of cAMP-dependent protein kinase suggests that lysine 233 in kinase subdomain I may provide this function.	Lysine	83-89	WNK lysine deficient protein kinase 1	Homo sapiens	11-15
10828064-9	2000	Mutation of this lysine residue to methionine eliminates WNK1 activity, consistent with the conclusion that it is required for catalysis.	Lysine	17-23	WNK lysine deficient protein kinase 1	Homo sapiens	57-61
10842153-10	2000	LY 294002 inhibited TSP-1-, Fn-, and Vn-stimulated VSMC migration (85% to 89%, P &lt;.05).	Lysine	0-2	vitronectin	Bos taurus	37-39
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	chromobox 7	Homo sapiens	4-15
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	chromobox 7	Homo sapiens	17-21
26830124-1	2016	Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first discovered in 1980, plays a critical role in diverse nuclear processes including the regulation of transcription and DNA damage repair.	Lysine	33-39	H2B clustered histone 21	Homo sapiens	26-29
26830124-1	2016	Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first discovered in 1980, plays a critical role in diverse nuclear processes including the regulation of transcription and DNA damage repair.	Lysine	33-39	H2B clustered histone 21	Homo sapiens	45-48
26830124-2	2016	Herein, we use a suite of protein chemistry methods to explore how H2B-Ub stimulates hDot1L-mediated methylation of histone H3 on lysine 79 (H3K79me).	Lysine	130-136	H2B clustered histone 21	Homo sapiens	67-70
33496017-0	2021	The Lys 280   Gln mutation mimicking disease-linked acetylation of Lys 280 in tau extends the structural core of fibrils and modulates their catalytic properties.	Lysine	4-7	microtubule associated protein tau	Homo sapiens	78-81
33496017-4	2021	Several PTMs, including acetylation at Lys 280, increase aggregation of tau in the brain, and increase neurodegeneration.	Lysine	39-42	microtubule associated protein tau	Homo sapiens	72-75
33496017-5	2021	In this study, tau-K18 K280Q, in which the Lys 280   Gln mutation is used to mimic acetylation at Lys 280, is shown, using HX-MS measurements, to form fibrils with a structural core that is longer than that of tau-K18 fibrils.	Lysine	43-46	microtubule associated protein tau	Homo sapiens	15-18
33496017-5	2021	In this study, tau-K18 K280Q, in which the Lys 280   Gln mutation is used to mimic acetylation at Lys 280, is shown, using HX-MS measurements, to form fibrils with a structural core that is longer than that of tau-K18 fibrils.	Lysine	43-46	microtubule associated protein tau	Homo sapiens	210-213
33496017-9	2021	Thus, the effect of Lys 280 acetylation on tau aggregate propagation in brain cells is expected to depend on the amount of acetylated tau present, and on whether the propagating seed is acetylated at Lys 280 or not.	Lysine	20-23	microtubule associated protein tau	Homo sapiens	43-46
33496017-9	2021	Thus, the effect of Lys 280 acetylation on tau aggregate propagation in brain cells is expected to depend on the amount of acetylated tau present, and on whether the propagating seed is acetylated at Lys 280 or not.	Lysine	20-23	microtubule associated protein tau	Homo sapiens	134-137
33496017-9	2021	Thus, the effect of Lys 280 acetylation on tau aggregate propagation in brain cells is expected to depend on the amount of acetylated tau present, and on whether the propagating seed is acetylated at Lys 280 or not.	Lysine	200-203	microtubule associated protein tau	Homo sapiens	43-46
10850706-7	2000	Most contacts in the complex are between KIR and conserved HLA-C residues, but a hydrogen bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.	Lysine	103-106	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	41-44
33959363-2	2021	The results showed that CyP6Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine.	Lysine	121-127	peptidylprolyl isomerase G	Homo sapiens	24-27
26708453-3	2016	The DHTKD1 enzyme is hypothesized to catalyze the oxidative decarboxylation of 2-oxoadipate, a shared intermediate of the degradative pathways for tryptophan, lysine and hydroxylysine.	Lysine	159-165	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	4-10
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Lysine	115-118	plasminogen	Homo sapiens	13-20
33789369-8	2021	The small interfering RNA of KDM6B (KDM6B siRNA) was used to silence the expression of KDM6B and the protein levels of KDM6B, F4/80 and tri-methylation of lysine 27 of histone H3 (H3K27me3) induced by HBx gene transfection were detected by Western blotting.	Lysine	155-161	X protein	Hepatitis B virus	201-204
18944551-3	2000	The substitution of Ile for Arg at position 180 in the conserved motif Phe-Arg-Asn-Lys (FRNK) of potyviruses was found to affect symptom expression.	Lysine	83-86	protein tyrosine kinase 2	Homo sapiens	88-92
33387462-8	2021	Furthermore, immunoprecipitation and use of a lysine acetylation assay showed that Sirtuin1 (SIRT1) mediated the PGC-1alpha deacetylation, which is involved in Nlrp3 inflammasome activation.	Lysine	46-52	sirtuin 1	Mus musculus	83-91
33387462-8	2021	Furthermore, immunoprecipitation and use of a lysine acetylation assay showed that Sirtuin1 (SIRT1) mediated the PGC-1alpha deacetylation, which is involved in Nlrp3 inflammasome activation.	Lysine	46-52	sirtuin 1	Mus musculus	93-98
33387462-8	2021	Furthermore, immunoprecipitation and use of a lysine acetylation assay showed that Sirtuin1 (SIRT1) mediated the PGC-1alpha deacetylation, which is involved in Nlrp3 inflammasome activation.	Lysine	46-52	NLR family, pyrin domain containing 3	Mus musculus	160-165
26614167-3	2016	These defects were partially recovered when the ILK-depleted OLs were instead grown on the non-integrin-activating substrate poly-l-lysine.	Lysine	125-138	integrin linked kinase	Mus musculus	48-51
26614167-4	2016	Intriguingly, ILK loss on the neutral poly-l-lysine substrate led to swelling at the tips of OL processes, which we identified as enlarged growth cones.	Lysine	38-51	integrin linked kinase	Mus musculus	14-17
26614167-13	2016	Strikingly, loss of ILK on poly-l-lysine leads to growth cone swelling, the structure"s size and motility rendered less dynamic.	Lysine	27-40	integrin linked kinase	Mus musculus	20-23
26486419-8	2016	In addition, sequence analysis of peptides displaying increased acetylation in GCLM knockout astrocytes revealed an enrichment of cysteine residues in the vicinity of the acetylation site, which suggests potential crosstalk between lysine-acetylation and cysteine modification.	Lysine	232-238	glutamate-cysteine ligase, modifier subunit	Mus musculus	79-83
26635363-4	2016	Of the PTMs identified, lysine acetylation (AcK) and arginine mono-methylation (Rme) were more prevalent than other PTMs.	Lysine	24-30	tyrosine kinase non receptor 2	Homo sapiens	44-47
10747782-6	2000	However, alanine substitution of two lysine residues (116 and 122) within the C-terminal extension (tail) of Mbp1 considerably reduces the apparent affinity for an MCB (MluI cell-cycle box) containing oligonucleotide.	Lysine	37-43	transcription factor MBP1	Saccharomyces cerevisiae S288C	109-113
26656312-0	2016	Clinical and molecular investigation in Chinese patients with glutaric aciduria type I. Glutaric aciduria type I (GA-I) is a rare autosomal recessive metabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCDH), leading to an abnormal metabolism of lysine, hydroxylysine and tryptophan.	Lysine	265-271	glutaryl-CoA dehydrogenase	Homo sapiens	221-225
33137372-6	2021	Here we apply SILCS-Biologics on a Fab domain of a monoclonal antibody (mAbN) to model Fab-Fab interactions and interactions with three amino acid excipients, namely, arginine HCl, proline and lysine HCl.	Lysine	193-203	FA complementation group B	Homo sapiens	87-90
33137372-6	2021	Here we apply SILCS-Biologics on a Fab domain of a monoclonal antibody (mAbN) to model Fab-Fab interactions and interactions with three amino acid excipients, namely, arginine HCl, proline and lysine HCl.	Lysine	193-203	FA complementation group B	Homo sapiens	87-90
10734177-6	2000	Next, SDS-polyacrylamide gel electrophoresis analysis revealed that chemically cross-linked (125)I-angiotensinogen 3-11(Lys(11)) specifically bound a protein of M(r) 173,000 that had the same molecular weight as ACE.	Lysine	120-123	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	212-215
33738331-1	2021	Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3.	Lysine	114-120	lysine (K)-specific methyltransferase 2D	Mus musculus	152-157
33738331-1	2021	Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3.	Lysine	196-202	lysine (K)-specific methyltransferase 2D	Mus musculus	152-157
33738331-4	2021	Since lysine-specific demethylase 1A (LSD1/KDM1A) normally removes the H3K4 methyl marks added by KMT2D, we hypothesized that inhibition of KDM1A demethylase activity may ameliorate molecular and phenotypic defects stemming from KMT2D loss.	Lysine	6-12	lysine (K)-specific methyltransferase 2D	Mus musculus	98-103
33738331-4	2021	Since lysine-specific demethylase 1A (LSD1/KDM1A) normally removes the H3K4 methyl marks added by KMT2D, we hypothesized that inhibition of KDM1A demethylase activity may ameliorate molecular and phenotypic defects stemming from KMT2D loss.	Lysine	6-12	lysine (K)-specific methyltransferase 2D	Mus musculus	229-234
26405201-5	2016	PKM2 contributes to enhancement of transcription of cytochrome P450 1A1 (CYP1A1), an AhR-target gene, acetylation at lysine 9 of histone H3 at the CYP1A1 enhancer.	Lysine	117-123	pyruvate kinase M1/2	Homo sapiens	0-4
26405201-5	2016	PKM2 contributes to enhancement of transcription of cytochrome P450 1A1 (CYP1A1), an AhR-target gene, acetylation at lysine 9 of histone H3 at the CYP1A1 enhancer.	Lysine	117-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	52-71
26405201-5	2016	PKM2 contributes to enhancement of transcription of cytochrome P450 1A1 (CYP1A1), an AhR-target gene, acetylation at lysine 9 of histone H3 at the CYP1A1 enhancer.	Lysine	117-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
26405201-5	2016	PKM2 contributes to enhancement of transcription of cytochrome P450 1A1 (CYP1A1), an AhR-target gene, acetylation at lysine 9 of histone H3 at the CYP1A1 enhancer.	Lysine	117-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	147-153
26701885-1	2016	SET7/9, a histone methyltransferase, has two distinct functions for lysine methylation.	Lysine	68-74	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
10734177-11	2000	These experiments indicate that the novel angiotensin I analog, (125)I-angiotensinogen 3-11(Lys(11)) binds to ACE and suggest that there are critical binding sites outside the catalytic domains of ACE that determine binding specificity and affinity.	Lysine	92-95	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	110-113
33589584-4	2021	Overexpressed histone methyltransferase NSD2 in patients bearing a t(4;14) translocation or in BTZ-resistant MM cells coordinates elevated SRC-3 by enhancing its liquid-liquid phase separation to supranormally modify histone H3 lysine 36 dimethylation (H3K36me2) modifications on promoters of anti-apoptotic genes.	Lysine	228-234	nuclear receptor coactivator 3	Homo sapiens	139-144
10734177-11	2000	These experiments indicate that the novel angiotensin I analog, (125)I-angiotensinogen 3-11(Lys(11)) binds to ACE and suggest that there are critical binding sites outside the catalytic domains of ACE that determine binding specificity and affinity.	Lysine	92-95	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	197-200
10694430-10	2000	A lysine to arginine mutation abolished MITF (K201R) degradation by hUBC9 in vivo.	Lysine	2-8	ubiquitin conjugating enzyme E2 I	Homo sapiens	68-73
33567280-3	2021	Here, we characterize GR"s protein interactome and find the SETD1A (SET domain containing 1A)/COMPASS (complex of proteins associated with Set1) histone H3 lysine 4 (H3K4) methyltransferase complex highly enriched in activated mouse macrophages.	Lysine	156-162	SET domain containing 1A	Mus musculus	60-66
33567280-3	2021	Here, we characterize GR"s protein interactome and find the SETD1A (SET domain containing 1A)/COMPASS (complex of proteins associated with Set1) histone H3 lysine 4 (H3K4) methyltransferase complex highly enriched in activated mouse macrophages.	Lysine	156-162	SET domain containing 1A	Mus musculus	68-92
26748706-0	2016	The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.	Lysine	95-101	carnitine acetyltransferase	Mus musculus	37-64
26751588-5	2016	Overexpression of PHF8 catalyzed the removal of methyl-groups from histone 3 lysine 9 (H3K9) and H4K20, whereas knockdown of the enzyme increased H3K9 methylation.	Lysine	77-83	PHD finger protein 8 L homeolog	Xenopus laevis	18-22
26555266-5	2016	Using a highly sensitive solution fluorescence assay, we have examined binding of CR456 to arginine and lysine variants of PAI-1 and definitively identified the binding site as composed of four basic residues, Lys-69, Arg-76, Lys-80, and Lys-88.	Lysine	104-110	serpin family E member 1	Homo sapiens	123-128
33546767-7	2021	We found that inhibition of NAMPT or SIRT2 in iPS cells induces p53 protein by promoting its lysine acetylation.	Lysine	93-99	sirtuin 2	Homo sapiens	37-42
10759708-4	2000	TAFI can be activated by thrombin, and in its activated form potently attenuates fibrinolysis by removing C-terminal lysine and arginine residues that are important for the binding and activation of plasminogen.	Lysine	117-123	carboxypeptidase B2	Homo sapiens	0-4
28959535-5	2016	Moreover, we revealed that the global histone 3 lysine 27 trimethylation (H3K27me3) modification was positively associated with the degree of genetic damage (beta = 0.061, P &lt; 0.001) and the increase of HOTAIR expression (beta = 0.385, P = 0.018).	Lysine	48-54	HOX transcript antisense RNA	Homo sapiens	206-212
26742748-2	2016	Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content.	Lysine	61-64	fibronectin type III domain containing 5	Homo sapiens	131-137
10657126-5	2000	The optimal P4 to P2 substrate specificity for plasmin was P4-Lys/Nle (norleucine)/Val/Ile/Phe, P3-Xaa, and P2-Tyr/Phe/Trp.	Lysine	62-65	plasminogen	Homo sapiens	47-54
26742748-3	2016	The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.	Lysine	51-54	fibronectin type III domain containing 5	Homo sapiens	136-142
26554302-4	2016	RESULTS: Carriers of XRCC1 glutamine (Gln), XRCC3 threonine (Thr), hOGG1 cysteine (Cys), and XPD lysine (Lys) alleles were significantly more frequent among the cohort of schizophrenia patients than in controls.	Lysine	97-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	93-96
26554302-6	2016	Moreover, healthy relatives had significantly higher frequencies of XRCC3 Thr+ and XPD Lys+ genotypes than unrelated healthy controls.	Lysine	87-90	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	83-86
33189720-3	2021	Isolated vacuolar membrane vesicles from S. cerevisiae cells overexpressing stm1+ exhibited stm1+-dependent arginine and lysine uptake activity.	Lysine	121-127	Stm1p	Saccharomyces cerevisiae S288C	76-80
33189720-3	2021	Isolated vacuolar membrane vesicles from S. cerevisiae cells overexpressing stm1+ exhibited stm1+-dependent arginine and lysine uptake activity.	Lysine	121-127	Stm1p	Saccharomyces cerevisiae S288C	92-96
33189720-5	2021	The expression levels of stm1+ in S. pombe cells significantly affected the vacuolar contents of lysine, histidine, and arginine.	Lysine	97-103	Stm1p	Saccharomyces cerevisiae S288C	25-29
10662499-1	2000	A hydrophilic matrix of periodate-oxidized dextran was used as a double-sided linker to covalently immobilize Staphylococcus aureus protein A (SpA) molecules onto a poly-L-lysine-modified piezoelectric crystal surface to improve their stability, activity, and binding specificity with human immunoglobulin G (IgG) in flow injection assays.	Lysine	165-178	surfactant protein A1	Homo sapiens	143-146
33175428-5	2021	Common feature of [ 1 +AA+H] +   complexes is the presence of a protonated AA bound to neutral 1 , in spite of the fact that the gas phase basicity of 1 is comparable to the one of Lys and His.	Lysine	181-184	aspartate beta-hydroxylase	Homo sapiens	23-27
33175428-7	2021	Within [ 1 +AA+H] +   the side chain substituents (imidazole group for His and terminal amino group for Lys) present comparable basic properties as the a-amino group, taking part to a cooperative H-bond network.	Lysine	104-107	aspartate beta-hydroxylase	Homo sapiens	12-16
26045091-1	2016	TGF-beta1 activity results in methylation of lysine 4 of histone H3 (H3K4) through SET domain-containing lysine methyltransferase 7/9 (SET7/9) induction, which is important for the transcriptional activation of fibrotic genes in vitro.	Lysine	45-51	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	83-133
26045091-1	2016	TGF-beta1 activity results in methylation of lysine 4 of histone H3 (H3K4) through SET domain-containing lysine methyltransferase 7/9 (SET7/9) induction, which is important for the transcriptional activation of fibrotic genes in vitro.	Lysine	45-51	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	135-141
10650993-2	2000	Calmodulin labelled with the fluorophore 5-([4,6 dichlorotriazin-2yl]amino)-fluorescein (FL-CaM) does not change its fluorescence when it binds calcium, while calmodulin labelled at lysine 75 with 2-chloro-(6-(4-N,N-diethylamino-phenyl)-1,4,5-triazin-4-yl (TA-CaM), an environment-sensitive probe, increases its fluorescence when it binds calcium.	Lysine	182-188	calmodulin 1	Rattus norvegicus	0-10
27121714-1	2016	Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., alpha-tubulin, Hsp90 and cortactin.	Lysine	78-84	heat shock protein 90 alpha family class A member 1	Homo sapiens	152-157
26548512-4	2016	The results demonstrated that the transcriptional activities of Wnt2b and Wnt7b were abnormally upregulated in mouse fetuses with NTDs and, in the GC-rich promoters of these genes, histone 3 lysine 4 (H3K4) acetylation was enriched, whereas H3K27 trimethylation was reduced.	Lysine	191-197	wingless-type MMTV integration site family, member 2B	Mus musculus	64-69
33079209-5	2021	Previous work shows that C-terminal phosphorylation of S. cerevisiae Pif1 regulates its telomere maintenance activity, and we recently identified that Pif1 is also regulated by lysine acetylation.	Lysine	177-183	DNA helicase PIF1	Saccharomyces cerevisiae S288C	69-73
33079209-5	2021	Previous work shows that C-terminal phosphorylation of S. cerevisiae Pif1 regulates its telomere maintenance activity, and we recently identified that Pif1 is also regulated by lysine acetylation.	Lysine	177-183	DNA helicase PIF1	Saccharomyces cerevisiae S288C	151-155
33079209-6	2021	The over-expression toxicity of Pif1 was exacerbated in cells lacking the Rpd3 lysine deacetylase, but mutation of the NuA4 lysine acetyltransferase subunit Esa1 ameliorated this toxicity.	Lysine	79-85	DNA helicase PIF1	Saccharomyces cerevisiae S288C	32-36
33079209-9	2021	It is currently unclear what triggers lysine acetylation of Pif1 and how this modification impacts the many in vivo functions of the helicase, but future work promises to shed light on how this protein is tightly regulated within the cell.	Lysine	38-44	DNA helicase PIF1	Saccharomyces cerevisiae S288C	60-64
10601259-3	1999	The alpha-carbon of the conserved lysine present near the C-terminal end of the transmembrane helix (Lys(1125) in alpha2, Lys(1022) in alpha5, Lys(752) in beta1, and Lys(724) in beta2) is buried in the plasma membrane, and the charged amino group most likely reaches into the polar head-group region of the lipid bilayer.	Lysine	34-40	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	178-183
32594524-2	2021	A conserved lysine in the lariat loop of arrestins directly binds the phosphate in crystal structures of activated arrestin-1, -2, and -3.	Lysine	12-18	S-antigen, retina and pineal gland (arrestin)	Mus musculus	115-137
32594524-5	2021	We tested the role of this lysine by introducing charge elimination (Lys->Ala) and reversal (Lys->Glu) mutations in arrestin-1, -2, and -3.	Lysine	27-33	S-antigen, retina and pineal gland (arrestin)	Mus musculus	116-138
27094172-8	2016	Docking studies indicated that compound 5c readily binds the active site of human glyoxalase I protein via two strong hydrogen bonds engaging residues of Glu-99 and Lys-156.	Lysine	165-168	glyoxalase I	Homo sapiens	82-94
26556865-4	2015	In this process, PPARalpha/C102 was critical for PPARalpha binding to BH3 domain of Bcl2, subsequently, PPARalpha transferred K48-linked polyubiquitin to lysine-22 site of Bcl2 resulting in its ubiquitination and proteasome-dependent degradation.	Lysine	154-160	peroxisome proliferator activated receptor alpha	Homo sapiens	17-26
26556865-4	2015	In this process, PPARalpha/C102 was critical for PPARalpha binding to BH3 domain of Bcl2, subsequently, PPARalpha transferred K48-linked polyubiquitin to lysine-22 site of Bcl2 resulting in its ubiquitination and proteasome-dependent degradation.	Lysine	154-160	peroxisome proliferator activated receptor alpha	Homo sapiens	49-58
26556865-4	2015	In this process, PPARalpha/C102 was critical for PPARalpha binding to BH3 domain of Bcl2, subsequently, PPARalpha transferred K48-linked polyubiquitin to lysine-22 site of Bcl2 resulting in its ubiquitination and proteasome-dependent degradation.	Lysine	154-160	peroxisome proliferator activated receptor alpha	Homo sapiens	49-58
10585493-1	1999	We have previously shown that human cullin-2 (Cul-2) is covalently modified at Lys-689 by NEDD8 (Wada, H., Yeh, E. T. H., and Kamitani, T. (1999) Biochem.	Lysine	79-82	NEDD8 ubiquitin like modifier	Homo sapiens	90-95
26560027-6	2015	We show that SNP rs2168101 G&gt;T is the most highly associated variant (combined P = 7.47 x 10(-29), odds ratio 0.65, 95% confidence interval 0.60-0.70), and resides in a super-enhancer defined by extensive acetylation of histone H3 lysine 27 within the first intron of LMO1.	Lysine	234-240	LIM domain only 1	Homo sapiens	271-275
33356257-4	2021	Ultralong pharmacokinetic profiles were obtained by attaching an albumin-binding side chain derived from octadecanedioic (C18) or icosanedioic acid (C20) to the lysine in position B29.	Lysine	161-167	albumin	Canis lupus familiaris	65-72
10587450-4	1999	In the present study, residue M208 in GST A1-1 has been mutated to Lys and Glu, and residue F220 to Ala and Thr.	Lysine	67-70	glutathione S-transferase alpha 1	Homo sapiens	38-46
26673323-4	2015	Instead, it requires the PHD motif of KDM5 that binds to histone H3 that is di- or trimethylated on lysine 4 (H3K4me2/3).	Lysine	100-106	little imaginal discs	Drosophila melanogaster	38-42
11196659-4	1999	In the present studies, sequence analyses for structural and promoter regions of Plat revealed a single nucleotide polymorphism encoding a catalytic domain of t-PA, with an amino acid substitution of anionic Glu366 in NZW for a cationic Lys in BXSB.	Lysine	237-240	plasminogen activator, tissue	Mus musculus	81-85
26399631-8	2015	We also discovered a novel K27M mutation in HIST2H3C, and a lysine-to-isoleucine substitution (K27I) in H3F3A, also creating a loss of trimethylation.	Lysine	60-66	H3.3 histone A	Homo sapiens	104-109
33290556-6	2021	By exchanging arginine to a lysine, the corresponding side chain in DNMT3B, the sequence preference is reversed, confirming the requirement for arginine at this position.	Lysine	28-34	DNA methyltransferase 3 beta	Homo sapiens	68-74
33423247-1	2021	Glutaricacidemia type 1(GA1) is an autosomal recessive disease caused by reduced or missing glutaryl-CoA dehydrogenase activity which hamps metabolism of lysine, hydroxylysine and tryptophan.	Lysine	154-160	glutaryl-CoA dehydrogenase	Homo sapiens	92-118
26422133-3	2015	We focused on how GG-NER relates to histone acetylation for its functioning and we identified the histone acetyltransferase Gcn5 and acetylation at lysines 9/14 of histone H3 as a major factor in enabling efficient repair.	Lysine	148-155	histone acetyltransferase GCN5	Saccharomyces cerevisiae S288C	98-128
11196659-4	1999	In the present studies, sequence analyses for structural and promoter regions of Plat revealed a single nucleotide polymorphism encoding a catalytic domain of t-PA, with an amino acid substitution of anionic Glu366 in NZW for a cationic Lys in BXSB.	Lysine	237-240	plasminogen activator, tissue	Mus musculus	159-163
10619020-4	1999	Here, we provide a molecular explanation of this phenomenon and report that MyoD is directly acetylated by PCAF at evolutionarily conserved lysines.	Lysine	140-147	lysine acetyltransferase 2B	Homo sapiens	107-111
33002579-3	2021	Sirtuin-3 (SIRT3) is a class III histone deacetylase and regulates lysine acetylation in mitochondria.	Lysine	67-73	sirtuin 3	Mus musculus	0-9
33002579-3	2021	Sirtuin-3 (SIRT3) is a class III histone deacetylase and regulates lysine acetylation in mitochondria.	Lysine	67-73	sirtuin 3	Mus musculus	11-16
10531318-5	1999	Deletion of the MH1 domain as well as mutations of four lysine residues in the MH1 domain abrogated the inhibitory activity of Smad3, but did not compromise the self-stimulatory function.	Lysine	56-62	SMAD family member 3	Homo sapiens	127-132
26341139-0	2015	Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis.	Lysine	51-57	X protein	Hepatitis B virus	0-27
10480954-5	1999	Recombinant granzyme K cleaves synthetic thiobenzyl ester substrates after Lys and Arg with k(cat)/K(m) values of 3.7 x 10(4) and 4.4 x 10(4) M(-1) s(-1), respectively.	Lysine	75-78	granzyme K	Homo sapiens	12-22
26391951-0	2015	Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.	Lysine	65-71	structural maintenance of chromosomes flexible hinge domain containing 1	Homo sapiens	30-36
26391951-5	2015	We further show that the principal mechanism for chromatin loading of SMCHD1 involves an LRIF1-mediated interaction with HP1gamma at trimethylated histone H3 lysine 9 (H3K9me3)-modified chromatin sites on the chromosome arms.	Lysine	158-164	structural maintenance of chromosomes flexible hinge domain containing 1	Homo sapiens	70-76
33201593-2	2021	MLL1 is a histone H3 lysine 4 trimethylation (H3K4me3) transferase that regulates the transcriptional activation of target genes.	Lysine	21-27	lysine methyltransferase 2A	Homo sapiens	0-4
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Lysine	49-55	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	237-242
32242051-3	2021	MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methylation (H3K79me2/3).	Lysine	125-131	lysine methyltransferase 2A	Homo sapiens	0-3
26383163-8	2015	Mechanistically, HDAC8 physically interacted with the chromatin modifier EZH2 to concordantly repress Wnt antagonists via histone H4 deacetylation and H3 lysine 27 trimethylation.	Lysine	154-160	histone deacetylase 8	Homo sapiens	17-22
10419890-2	1999	We show that a peptide between amino acids 47 and 70 that contains the heparin-binding lysine-rich site inhibits FGF-2 or VEGF function.	Lysine	87-93	fibroblast growth factor 2	Cricetulus griseus	113-118
26522327-4	2015	SIRT1 directly interacted with HMGB1 via its N-terminal lysine residues (28-30), and thereby inhibited HMGB1 release to improve survival in an experimental model of sepsis.	Lysine	56-62	sirtuin 1	Mus musculus	0-5
26470845-2	2015	Here we present data supporting a role for an ASXL1-BAP1 complex in the deubiquitylation of mono-ubiquitylated lysine 119 on Histone H2A (H2AK119ub1) in vivo.	Lysine	111-117	ASXL transcriptional regulator 1	Mus musculus	46-51
33456583-11	2021	Notably, the lysine 64 residue on SHMT2 (SHMT2K64) mediated its interaction with beta-catenin.	Lysine	13-19	catenin beta 1	Homo sapiens	81-93
33362253-2	2020	GNAT enzymes transfer an acyl moiety from acyl coenzyme A to a wide range of substrates including aminoglycosides, serotonin, glucosamine-6-phosphate, protein N-termini and lysine residues of histones and other proteins.	Lysine	173-179	glycine-N-acyltransferase like 1	Homo sapiens	0-4
10414965-5	1999	Substitution of these four amino acids-glycine 171, lysine 173, glutamate 179, and arginine 180-into the beta2 subunit was sufficient to enable the beta2 subunit to homo-oligomerize.	Lysine	52-58	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-110
26437366-1	2015	The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub).	Lysine	132-138	ASXL transcriptional regulator 1	Mus musculus	31-36
10414965-5	1999	Substitution of these four amino acids-glycine 171, lysine 173, glutamate 179, and arginine 180-into the beta2 subunit was sufficient to enable the beta2 subunit to homo-oligomerize.	Lysine	52-58	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
33012513-7	2020	Notably, serine 16 and lysine 63 residues of PIN1 were critical for its interaction with HIF-2alpha.	Lysine	23-29	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	45-49
26375672-4	2015	Our results show that the depletion of all p73 isoforms cause altered lysine metabolism and glycolysis, distinct patterns for glutathione synthesis and Krebs cycle, as well as an elevated pentose phosphate pathway and abnormal lipid accumulation.	Lysine	70-76	transformation related protein 73	Mus musculus	43-46
33012513-7	2020	Notably, serine 16 and lysine 63 residues of PIN1 were critical for its interaction with HIF-2alpha.	Lysine	23-29	endothelial PAS domain protein 1	Homo sapiens	89-99
10383441-1	1999	We have reported that bovine DNase I, a secretory glycoprotein, acquires mannose 6-phosphate residues on 12.6% of its Asn-linked oligosaccharides when expressed in COS-1 cells and that the extent of phosphorylation increases to 79.2% when lysines are placed at positions 27 and 74 of the mature protein (Nishikawa, A., Gregory, W. , Frenz, J., Cacia, J., and Kornfeld, S. (1997) J. Biol.	Lysine	239-246	deoxyribonuclease 1	Bos taurus	29-36
33326776-2	2020	Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.	Lysine	90-96	eukaryotic translation initiation factor 5A	Homo sapiens	111-154
26384289-1	2015	A small library of monovalent and bivalent Smac mimics was synthesized based on 2 types of monomers, with general structure NMeAla-Xaa-Pro-BHA (Xaa=Cys or Lys).	Lysine	155-158	diablo IAP-binding mitochondrial protein	Homo sapiens	43-47
33326776-2	2020	Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.	Lysine	90-96	eukaryotic translation initiation factor 5A	Homo sapiens	156-161
26469956-7	2015	Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter.	Lysine	232-238	HOX transcript antisense RNA	Homo sapiens	35-41
10406457-5	1999	Alanine substitutions further demonstrated that lysine 240, asparagine 242, and serine 243 are key residues for AT2-induced apoptosis, ERK inhibition, and SHP-1 activation.	Lysine	48-54	angiotensin II receptor, type 2	Rattus norvegicus	112-115
26469956-7	2015	Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter.	Lysine	232-238	HOX transcript antisense RNA	Homo sapiens	43-71
33326781-4	2020	DOT1L-dependent dimethylation of lysine 79 of histone H3 (H3K79me2) is associated with lineage-specific gene expression.	Lysine	33-39	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	0-5
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	methyl-CpG binding domain protein 2	Homo sapiens	79-90
26507377-0	2015	Lysine-acetylation as a fundamental regulator of Ran function: Implications for signaling of proteins of the Ras-superfamily.	Lysine	0-6	RAN, member RAS oncogene family	Homo sapiens	49-52
10406457-5	1999	Alanine substitutions further demonstrated that lysine 240, asparagine 242, and serine 243 are key residues for AT2-induced apoptosis, ERK inhibition, and SHP-1 activation.	Lysine	48-54	protein tyrosine phosphatase, non-receptor type 6	Rattus norvegicus	155-160
26507377-4	2015	Recently, several lysine-acetylation sites in Ran were identified by quantitative mass-spectrometry, some being located in highly important regions such as the P-loop, switch I, switch II and the G5/SAK motif.	Lysine	18-24	RAN, member RAS oncogene family	Homo sapiens	46-49
26507377-5	2015	We recently reported that lysine-acetylation regulates nearly all aspects of Ran-function such as RCC1 catalyzed nucleotide exchange, intrinsic nucleotide hydrolysis, its interaction with NTF2 and the formation of import- and export-complexes.	Lysine	26-32	RAN, member RAS oncogene family	Homo sapiens	77-80
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	lysine methyltransferase 2D	Homo sapiens	100-104
10387080-3	1999	We describe here the crystal structure at 2.8 A resolution of rabbit cytosolic SHMT (rcSHMT) in two forms: one with the PLP covalently bound as an aldimine to the Nepsilon-amino group of the active site lysine and the other with the aldimine reduced to a secondary amine.	Lysine	203-209	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	79-83
33043602-1	2020	Wiedemann-Steiner syndrome (WDSTS) is a rare autosomal dominant condition caused by heterozygous loss of function variants in the KMT2A (MLL) gene, encoding a lysine N-methyltransferase that mediates a histone methylation pattern specific for epigenetic transcriptional activation.	Lysine	159-165	lysine methyltransferase 2A	Homo sapiens	130-135
33043602-1	2020	Wiedemann-Steiner syndrome (WDSTS) is a rare autosomal dominant condition caused by heterozygous loss of function variants in the KMT2A (MLL) gene, encoding a lysine N-methyltransferase that mediates a histone methylation pattern specific for epigenetic transcriptional activation.	Lysine	159-165	lysine methyltransferase 2A	Homo sapiens	137-140
26523565-5	2015	The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( &lt; 0.05) of pigs.	Lysine	4-7	IMF	Sus scrofa	64-67
26523565-5	2015	The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( &lt; 0.05) of pigs.	Lysine	30-33	IMF	Sus scrofa	64-67
25043748-1	2015	Enhancer of zeste homolog 2 (EZH2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and its demethylation is catalyzed by UTX.	Lysine	74-80	lysine (K)-specific demethylase 6A	Mus musculus	133-136
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Lysine	74-77	mal, T cell differentiation protein	Canis lupus familiaris	29-32
26134565-4	2015	The ability of RME-8 to associate with PI(3)P and early endosomes is largely abolished when residues Lys(17), Trp(20), Tyr(24), or Arg(26) are mutated resulting in diffuse cytoplasmic localization of RME-8 while maintaining the ability to interact with Hsc70.	Lysine	101-104	DnaJ heat shock protein family (Hsp40) member C13	Homo sapiens	15-20
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Lysine	74-77	mal, T cell differentiation protein	Canis lupus familiaris	151-154
33130515-0	2020	The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology.	Lysine	21-27	lysine acetyltransferase 6A	Homo sapiens	47-52
10374816-7	1999	These findings suggest that both proline and lysine are necessary for cortistatin binding to its specific receptor.	Lysine	45-51	cortistatin	Homo sapiens	70-81
33130515-0	2020	The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology.	Lysine	21-27	lysine acetyltransferase 6B	Homo sapiens	57-62
33130515-4	2020	The paralogous lysine acetyltransferases KAT6A and KAT6B which belong to the MYST family of acetyltransferases, were first discovered approximately 25 years ago.	Lysine	15-21	lysine acetyltransferase 6A	Homo sapiens	41-46
26285145-0	2015	HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.	Lysine	78-84	ring finger protein 8	Homo sapiens	43-64
26285145-0	2015	HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.	Lysine	78-84	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	120-124
32603918-6	2020	Myosin light chain (MYL1 and MYL3) showed high oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.	Lysine	167-173	myosin light chain 1	Homo sapiens	20-24
10386876-7	1999	The homology model supports a ubiquitin-like fold for SUb and suggests that two conserved Lys residues, corresponding to Lys48 and Lys63 of ubiquitin, are functionally important.	Lysine	90-93	ubiquitin	Saccharomyces cerevisiae S288C	30-39
26195811-5	2015	This resulted in severe and specific reduction in germline transcription, histone H3 acetylation, and histone H4 lysine 4 methylation of the Jgamma1 gene segment in adult thymus.	Lysine	113-119	T cell receptor gamma, joining region	Mus musculus	141-148
26212320-3	2015	During metabolic stress, SUMO1 modification of LKB1 lysine 178 is essential in promoting its interaction with AMPK via a SUMO-interacting motif (SIM) essential for AMPK activation.	Lysine	52-58	serine/threonine kinase 11	Homo sapiens	47-51
32676696-4	2020	At the promoter region of the IL-1beta gene, the demethylation of histone H3 lysine 27 (H3K27) was significantly induced for 1 week after transient stimulation with LPS and IFN-gamma.	Lysine	77-83	interleukin 1 alpha	Mus musculus	30-38
10386876-7	1999	The homology model supports a ubiquitin-like fold for SUb and suggests that two conserved Lys residues, corresponding to Lys48 and Lys63 of ubiquitin, are functionally important.	Lysine	90-93	ubiquitin	Saccharomyces cerevisiae S288C	140-149
10329707-8	1999	Copper trafficking to Ccc2p also relied on the lysine-rich face of Atx1p.	Lysine	47-53	Cu(2+)-transporting P-type ATPase CCC2	Saccharomyces cerevisiae S288C	22-27
33271741-3	2020	A human anti-gp41 antibody (7B2) was conjugated to two photosensitizers (PSs) with different charges through different linking strategies; "Click" conjugation by using an azide-bearing porphyrin attached via a disulfide bridge linker with a drug-to-antibody ratio (DAR) of exactly 4, and "Lysine" conjugation by using phthalocyanine IRDye 700DX dye with average DARs of 2.1, 3.0 and 4.4.	Lysine	289-295	secretogranin V	Homo sapiens	28-31
25354230-9	2015	The higher muscularity, MyHC IIb expression in Semitendinosus muscle and Lys serum of pigs fed the ADE diet suggest that Lys increases growth rate not only by functioning as protein construction unit but also as potential control of the protein synthesis process.	Lysine	121-124	myosin-4	Sus scrofa	24-32
10329179-8	1999	Furthermore, a novel electrophilic substrate, 4-chloro-3,5-dinitrobenzoic acid, with a carboxylate group expected to interact with residue 208 gives a higher kcat value with the lysine mutant than with wild-type GST A1-1.	Lysine	178-184	glutathione S-transferase alpha 1	Homo sapiens	212-220
25694334-7	2015	This lysine conjugate is currently being considered for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, and combines the anti-HER2 antibody trastuzumab (Herceptin( )), with the cytotoxic microtubule-inhibiting maytansine derivative, DM1.	Lysine	5-11	immunoglobulin heavy diversity 1-7	Homo sapiens	274-277
33011288-1	2020	SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins.	Lysine	52-58	SET and MYND domain containing 2	Homo sapiens	0-40
33011288-1	2020	SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins.	Lysine	52-58	SET and MYND domain containing 2	Homo sapiens	42-47
33011288-1	2020	SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins.	Lysine	121-127	SET and MYND domain containing 2	Homo sapiens	0-40
33011288-1	2020	SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins.	Lysine	121-127	SET and MYND domain containing 2	Homo sapiens	42-47
10320345-0	1999	Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.	Lysine	0-6	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	92-96
33011288-4	2020	Among our focused library, compounds 43 and 44 with amide link on site C showed reasonably improved potency indicating that modification on this fragment is more flexible and introduction of electrophilic warheads in this position might provide lysine-targeting covalent inhibitors for SMYD2.	Lysine	245-251	SET and MYND domain containing 2	Homo sapiens	286-291
26199140-3	2015	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.	Lysine	108-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-78
32668307-9	2020	The inhibitory effect of poly-l-lysine, histone mixture, and lactoferrin on the motility of actin-myosin was higher than that of lysozyme.	Lysine	25-38	myosin heavy chain 14	Homo sapiens	98-104
26189595-0	2015	Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	Lysine	83-89	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	22-72
26189595-0	2015	Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	Lysine	83-89	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	74-78
26189595-0	2015	Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation.	Lysine	83-89	toll like receptor 4	Homo sapiens	112-116
10320345-0	1999	Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.	Lysine	0-6	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	153-157
10320345-1	1999	A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5.	Lysine	37-43	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	170-174
10320345-1	1999	A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5.	Lysine	37-43	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	179-183
26124124-0	2015	Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation.	Lysine	64-70	RAN, member RAS oncogene family	Homo sapiens	26-29
10207070-3	1999	Using mass spectrum sequence analysis, we identified the lysine at position 2 as the predominant site acetylated by PCAF.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	116-120
26124124-3	2015	Recent proteomic screens identified five Ran lysine acetylation sites in human and eleven sites in mouse/rat tissues.	Lysine	45-51	RAN, member RAS oncogene family	Homo sapiens	41-44
26124124-5	2015	Here, we show that lysine acetylation interferes with essential aspects of Ran function: nucleotide exchange and hydrolysis, subcellular Ran localization, GTP hydrolysis, and the interaction with import and export receptors.	Lysine	19-25	RAN, member RAS oncogene family	Homo sapiens	75-78
32878983-0	2020	Lysine Acetylation Regulates the Activity of Nuclear Pif1.	Lysine	0-6	DNA helicase PIF1	Saccharomyces cerevisiae S288C	53-57
32878983-2	2020	We sought to determine how the various activities of Pif1 are regulated in vivo Here, we report lysine acetylation of nuclear Pif1 and demonstrate that it influences both Pif1"s cellular roles and core biochemical activities.	Lysine	96-102	DNA helicase PIF1	Saccharomyces cerevisiae S288C	53-57
26124124-5	2015	Here, we show that lysine acetylation interferes with essential aspects of Ran function: nucleotide exchange and hydrolysis, subcellular Ran localization, GTP hydrolysis, and the interaction with import and export receptors.	Lysine	19-25	RAN, member RAS oncogene family	Homo sapiens	137-140
10207070-4	1999	Lysine 2 is a prominent acetylation site in vivo, suggesting that this PCAF-mediated acetylation is physiologically relevant.	Lysine	0-6	lysine acetyltransferase 2B	Homo sapiens	71-75
32878983-2	2020	We sought to determine how the various activities of Pif1 are regulated in vivo Here, we report lysine acetylation of nuclear Pif1 and demonstrate that it influences both Pif1"s cellular roles and core biochemical activities.	Lysine	96-102	DNA helicase PIF1	Saccharomyces cerevisiae S288C	126-130
32878983-2	2020	We sought to determine how the various activities of Pif1 are regulated in vivo Here, we report lysine acetylation of nuclear Pif1 and demonstrate that it influences both Pif1"s cellular roles and core biochemical activities.	Lysine	96-102	DNA helicase PIF1	Saccharomyces cerevisiae S288C	126-130
26023081-12	2015	Consistently, chromatin immunoprecipitation revealed that JARID1B occupies and reduces the histone 3 lysine 4 methylation levels at the HOXA5 promoter, demonstrating a direct function of JARID1B in endothelial HOXA5 gene regulation.	Lysine	101-107	homeobox A5	Homo sapiens	136-141
10372548-5	1999	Also, the dimorphism at these residues from asparagine and lysine to serine and asparagine, respectively, are known to modulate interaction with the natural killer (NK) cell killer inhibitory receptor (KIR).	Lysine	59-65	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	202-205
26181363-5	2015	Further, we identify that CIITA is also modified by Lys(63)-linked ubiquitination.	Lysine	52-55	class II major histocompatibility complex transactivator	Homo sapiens	26-31
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	0-3	class II major histocompatibility complex transactivator	Homo sapiens	22-27
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	0-3	class II major histocompatibility complex transactivator	Homo sapiens	97-102
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	0-3	class II major histocompatibility complex transactivator	Homo sapiens	97-102
26181363-6	2015	Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.	Lysine	130-133	class II major histocompatibility complex transactivator	Homo sapiens	22-27
25918018-0	2015	A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.	Lysine	2-8	CDK2 associated cullin domain 1	Homo sapiens	72-78
33166409-8	2020	Labeled TAFI also accumulated on both fibrin fibers and activated platelet surfaces, which were Lys-binding-site-dependent and Lys-binding-site-independent, respectively.	Lysine	96-99	carboxypeptidase B2 (plasma)	Mus musculus	8-12
33166409-8	2020	Labeled TAFI also accumulated on both fibrin fibers and activated platelet surfaces, which were Lys-binding-site-dependent and Lys-binding-site-independent, respectively.	Lysine	127-130	carboxypeptidase B2 (plasma)	Mus musculus	8-12
10092517-6	1999	Mapping of the NEDD8-conjugation site revealed that Lys-689 in human cullin-2 is conjugated by NEDD8.	Lysine	52-55	NEDD8 ubiquitin like modifier	Homo sapiens	15-20
33037124-7	2020	In addition, we identified two charged residues (aspartate-214 and lysine-223), present on opposite faces of a predicted alpha helix in the CRD, which are essential for S-acylation of Sprouty-2.	Lysine	67-73	sprouty RTK signaling antagonist 2	Rattus norvegicus	184-193
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	119-122	PML nuclear body scaffold	Homo sapiens	130-133
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	119-122	ring finger protein 4	Homo sapiens	224-228
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	119-122	PML nuclear body scaffold	Homo sapiens	257-260
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	199-202	PML nuclear body scaffold	Homo sapiens	130-133
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	199-202	ring finger protein 4	Homo sapiens	224-228
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	199-202	PML nuclear body scaffold	Homo sapiens	257-260
10092517-6	1999	Mapping of the NEDD8-conjugation site revealed that Lys-689 in human cullin-2 is conjugated by NEDD8.	Lysine	52-55	NEDD8 ubiquitin like modifier	Homo sapiens	95-100
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	cullin 1	Homo sapiens	50-56
10092517-7	1999	Interestingly, the Lys residue at position 689 in cullin-2 is conserved in all cullin family members, including human cullin-1, -2, -3, -4A, -4B, and -5 and yeast cullin (Cdc53), suggesting the possibility that other cullin family members are conjugated by NEDD8/Rub1 at a Lys residue of equivalent position.	Lysine	19-22	cullin 1	Homo sapiens	118-152
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Lysine	55-61	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
33154164-2	2021	IDOL also controls its own stability through autoubiquitination, primarily at lysine 293.	Lysine	78-84	myosin regulatory light chain interacting protein	Homo sapiens	0-4
10215847-0	1999	The structural and functional role of lysine residues in the binding domain of cytochrome c in the electron transfer to cytochrome c oxidase.	Lysine	38-44	LOC104968582	Bos taurus	79-91
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	CD274 molecule	Homo sapiens	109-114
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	CD274 molecule	Homo sapiens	168-173
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	CD274 molecule	Homo sapiens	109-114
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	CD274 molecule	Homo sapiens	168-173
25997831-5	2015	Jmjd6 does catalyse 2OG-dependent C-5 hydroxylation of lysine residues in mRNA splicing-regulatory proteins and histones; there is also accumulating evidence that Jmjd6 plays a role in splicing (potentially in an iron- and oxygen-dependent manner) as well as in other processes regulating gene expression, including transcriptional pause release.	Lysine	55-61	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	163-168
10215847-0	1999	The structural and functional role of lysine residues in the binding domain of cytochrome c in the electron transfer to cytochrome c oxidase.	Lysine	38-44	LOC104968582	Bos taurus	120-132
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	195-198	ring finger protein 170	Homo sapiens	41-47
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	195-198	ring finger protein 170	Homo sapiens	60-66
10215847-6	1999	These changes are qualitatively different to those observed for cytochrome c oxidase upon poly-l-lysine binding.	Lysine	90-103	LOC104968582	Bos taurus	64-76
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	195-198	ring finger protein 170	Homo sapiens	60-66
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	208-211	ring finger protein 170	Homo sapiens	41-47
33106653-2	2020	We report that a long noncoding RNA (lncRNA), H19, associates with dystrophin and inhibits E3-ligase-dependent polyubiquitination at Lys 3584 (referred to as Ub-DMD) and its subsequent protein degradation.	Lysine	133-136	H19 imprinted maternally expressed transcript	Homo sapiens	46-49
10191282-3	1999	In solution, PLA2-Lp[a] was a monomer, and when assessed by sedimentation velocity it behaved like untreated Lp[a], in that it remained compact in NaCl solutions but assumed the extended form in the presence of 6-amino hexanoic acid, which was shown previously to have an affinity for the apo[a] lysine binding site II (LBS II) comprising kringles IV5-8.	Lysine	296-302	lipoprotein(a)	Homo sapiens	18-22
32345138-9	2020	Key words: Epigenetic modification; TAZ, NKX2-1, PAX8, thyroid; human embryonic stem cells; acetyl histone H4; acetylation of histone H4 at lysine 16; ATAC-seq.	Lysine	140-146	H4 clustered histone 6	Homo sapiens	126-136
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	208-211	ring finger protein 170	Homo sapiens	60-66
25882839-6	2015	CRISPR/Cas9-mediated genetic deletion of RNF170 showed that RNF170 mediates the addition of all of the ubiquitin conjugates known to become attached to activated IP3 receptors (monoubiquitin and Lys(48)- and Lys(63)-linked ubiquitin chains), and that wild-type and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.	Lysine	208-211	ring finger protein 170	Homo sapiens	60-66
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	58-64	KMT5A pseudogene 1	Homo sapiens	28-32
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	86-92	KMT5A pseudogene 1	Homo sapiens	28-32
10082574-7	1999	We also provide evidence showing that lysines located in helices 3 and 4, which define part of hRARalpha NCoA binding surface, contribute differently to (i) the transcriptional activity and (ii) the interaction of RXR-RAR heterodimers with SRC-1, when challenged by either natural or RAR-selective retinoids.	Lysine	38-45	nuclear receptor coactivator 1	Homo sapiens	105-109
25897119-4	2015	In this study, we show that Set7 methylates HIF-1alpha at lysine 32 and HIF-2alpha at lysine K29; this methylation inhibits the expression of HIF-1alpha/2alpha targets by impairing the occupancy of HIF-alpha on hypoxia response element of HIF target gene promoter.	Lysine	86-92	endothelial PAS domain protein 1	Homo sapiens	72-82
25897119-8	2015	These findings define a novel modification of HIF-1alpha/2alpha and demonstrate that Set7-medited lysine methylation negatively regulates HIF-alpha transcriptional activity and HIF-1alpha-mediated glucose homeostasis.	Lysine	98-104	KMT5A pseudogene 1	Homo sapiens	85-89
10082574-7	1999	We also provide evidence showing that lysines located in helices 3 and 4, which define part of hRARalpha NCoA binding surface, contribute differently to (i) the transcriptional activity and (ii) the interaction of RXR-RAR heterodimers with SRC-1, when challenged by either natural or RAR-selective retinoids.	Lysine	38-45	nuclear receptor coactivator 1	Homo sapiens	240-245
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Lysine	28-31	insulin receptor	Homo sapiens	93-109
25728577-0	2015	A novel chemical footprinting approach identifies critical lysine residues involved in the binding of receptor-associated protein to cluster II of LDL receptor-related protein.	Lysine	59-65	LDL receptor related protein associated protein 1	Homo sapiens	102-129
25728577-1	2015	Tandem mass tags (TMTs) were utilized in a novel chemical footprinting approach to identify lysine residues that mediate the interaction of receptor-associated protein (RAP) with cluster II of LDL (low-density lipoprotein) receptor (LDLR)-related protein (LRP).	Lysine	92-98	LDL receptor related protein associated protein 1	Homo sapiens	140-167
32768649-5	2020	Inhibition assays enabled the identification of a >200-fold selective MMP9 inhibitor when Lys was considered as a C-4 substituent, thus addressing gelatinase selectivity beyond the S1" subsite, which is a major driver for selectivity.	Lysine	90-93	complement C4A (Rodgers blood group)	Homo sapiens	114-117
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Lysine	174-177	insulin receptor	Homo sapiens	93-109
25728577-1	2015	Tandem mass tags (TMTs) were utilized in a novel chemical footprinting approach to identify lysine residues that mediate the interaction of receptor-associated protein (RAP) with cluster II of LDL (low-density lipoprotein) receptor (LDLR)-related protein (LRP).	Lysine	92-98	LDL receptor related protein associated protein 1	Homo sapiens	169-172
25728577-1	2015	Tandem mass tags (TMTs) were utilized in a novel chemical footprinting approach to identify lysine residues that mediate the interaction of receptor-associated protein (RAP) with cluster II of LDL (low-density lipoprotein) receptor (LDLR)-related protein (LRP).	Lysine	92-98	low density lipoprotein receptor	Homo sapiens	198-254
10026103-4	1999	We have shown by transient expression in HeLa cells of beta-galactosidase fusion proteins that the betaA subunit precursor contains a functional nuclear localization signal within the lysine-rich sequence corresponding to amino acids 231-244.	Lysine	184-190	galactosidase beta 1	Homo sapiens	55-73
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	57-60	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	57-60	LDL receptor related protein associated protein 1	Homo sapiens	164-167
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	66-69	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	66-69	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	66-69	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	66-69	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-7	2015	For full-length RAP, we observed that peptides including Lys(60), Lys(191), Lys(256), Lys(270) and Lys(305)-Lys(306) exhibited reduced modification with TMT in the RAP-cluster II complex.	Lysine	66-69	LDL receptor related protein associated protein 1	Homo sapiens	16-19
25728577-12	2015	Collectively, novel insight has been obtained into the contribution of lysine residues of RAP to cluster II binding.	Lysine	71-77	LDL receptor related protein associated protein 1	Homo sapiens	90-93
33051544-3	2020	In our current work, we identified lysine 473 (K473) on PAK4 as the primary methylation site by SETD6.	Lysine	35-41	p21 (RAC1) activated kinase 4	Homo sapiens	56-60
32246626-0	2020	The Janus face of N-terminal lysines in alpha-synuclein.	Lysine	29-36	synuclein alpha	Homo sapiens	40-55
10075894-5	1999	Assembly is sensitive to mutation of lysine residues in the amino-terminal tail of histone H4 whose acetylation is associated with nucleosome deposition in vivo.	Lysine	37-43	histone H4	Saccharomyces cerevisiae S288C	83-93
25978044-9	2015	In addition, an influence of ionic interactions on PDHC-binding to plasminogen as well as of lysine residues on the association of PDHA-D with plasminogen was confirmed.	Lysine	93-99	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	131-135
32681597-7	2020	Of the tested peptides, only [Lys(lauroyl) 27 ,Pro 30 ,Lys(DOTA) 31 ,Bip 32 ,Leu 34 ]NPY 27-36 showed high stability against peptidase degradation, thus representing the best-suited truncated NPY analog for the development of NPY(Y 1 )R-specific imaging agents.	Lysine	30-33	neuropeptide Y	Homo sapiens	85-88
9874795-6	1999	These results are consistent with a model that places arginine at position five of Ac1-11 in pockets 4 and 7 of the MHC groove, which is formed in part by residues 26, 28, 70, and 74 of Abetau and places lysine at position four of Ac1-11, previously shown to be a major MHC contact, in hydrophobic pocket 6.	Lysine	204-210	adenylate cyclase 1	Mus musculus	83-86
32681597-7	2020	Of the tested peptides, only [Lys(lauroyl) 27 ,Pro 30 ,Lys(DOTA) 31 ,Bip 32 ,Leu 34 ]NPY 27-36 showed high stability against peptidase degradation, thus representing the best-suited truncated NPY analog for the development of NPY(Y 1 )R-specific imaging agents.	Lysine	55-58	neuropeptide Y	Homo sapiens	85-88
32984640-5	2020	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase, and it interacts and ubiquitinates the asyn in atypical chains (lysine K6, K27, K29, and K33).	Lysine	150-156	TNF receptor associated factor 6	Homo sapiens	0-50
25795785-0	2015	A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.	Lysine	32-38	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	70-77
25795785-6	2015	Our approach identified lysine 130 of the mRNA splicing factor snRNP70 as a SETMAR substrate in vitro, and we show that the enzyme primarily generates monomethylation at this position.	Lysine	24-30	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	63-70
25795785-7	2015	Furthermore, we show that SETMAR methylates snRNP70 Lys-130 in cells.	Lysine	52-55	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	44-51
32984640-5	2020	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase, and it interacts and ubiquitinates the asyn in atypical chains (lysine K6, K27, K29, and K33).	Lysine	150-156	TNF receptor associated factor 6	Homo sapiens	52-57
9760244-4	1998	Edman sequencing of the photolabeled peptide of rabbit SHBG revealed a single sequence corresponding to peptidic fragment Leu-118-Lys-134.	Lysine	130-133	sex hormone-binding globulin	Oryctolagus cuniculus	55-59
25558815-14	2015	In conclusion, the L-lysine-induced pathology in Gcdh(-/-) mice depends on genetic and dietary parameters.	Lysine	19-27	glutaryl-Coenzyme A dehydrogenase	Mus musculus	49-53
25743599-5	2015	In the case of human polymerase eta, ubiquitination at four lysine residues in its C-terminus appears to regulate its ability to interact with PCNA and modulate TLS.	Lysine	60-66	proliferating cell nuclear antigen	Homo sapiens	143-147
25743599-7	2015	In this review, we will summarize the known lysine modifications of several key proteins involved in TLS; PCNA and Y-family polymerases eta, iota, kappa and Rev1 and we will discuss the potential regulatory effects of such modification in controlling TLS in vivo.	Lysine	44-50	proliferating cell nuclear antigen	Homo sapiens	106-110
32652263-5	2020	Compared with the Lys-rich metallopeptide (Ru1), however, the third-strand stabilizating effect of the Arg-rich one (Ru2) is slightly more marked, which may be due to differences in the interactions of arginine and lysine residues with the third strand of the triplex.	Lysine	18-21	doublecortin domain containing 2	Homo sapiens	117-120
9748216-8	1998	Because Ser183 is adjacent to positively charged lysine groups that resemble PIP2-binding regions in several other proteins, phosphorylation of this serine may affect the binding affinity of the syndecan-4 cytoplasmic tail to PIP2.	Lysine	49-55	syndecan 4	Homo sapiens	195-205
32652263-5	2020	Compared with the Lys-rich metallopeptide (Ru1), however, the third-strand stabilizating effect of the Arg-rich one (Ru2) is slightly more marked, which may be due to differences in the interactions of arginine and lysine residues with the third strand of the triplex.	Lysine	215-221	doublecortin domain containing 2	Homo sapiens	117-120
25918939-1	2015	In yeast Saccharomyces cerevisiae, ~3% of the lysine transfer RNA acceptor 1 (tRK1) pool is imported into mitochondria while the second isoacceptor, tRK2, fully remains in the cytosol.	Lysine	46-52	Trk2p	Saccharomyces cerevisiae S288C	149-153
32413437-8	2020	Treatment of BV2 cells with LPS significantly reduced acetylation of histone H3 at lysine 9 of the alpha7 nAChR promoter.	Lysine	83-89	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	99-111
9758677-1	1998	Palmitoyl derivatives of interferon alpha2b (p-IFNalpha) were prepared by covalent attachment of the fatty acid to lysine residues in the protein through a reaction with N-hydroxysuccinimide palmitate ester.	Lysine	115-121	interferon alpha 2	Homo sapiens	25-43
25853889-3	2015	We identified a conserved lysine-rich motif within the Rel homology domain (RHD) of NFkappaBp50, mutation of which abrogated the interaction of NFkappaBp50 with the SLR polyU and impaired NFkappaBp50 mediated MYB elongation.	Lysine	26-32	MYB proto-oncogene, transcription factor	Homo sapiens	209-212
25853889-4	2015	We observed that the TAR RNA-binding region of Tat is homologous to the NFkappaBp50 RHD lysine-rich motif, a finding consistent with HIV Tat acting as an effector of MYB transcriptional elongation in an SLR dependent manner.	Lysine	88-94	MYB proto-oncogene, transcription factor	Homo sapiens	166-169
25466885-3	2015	We hypothesized that IUGR disrupts the normal developmental maturation of hepatic IGF-1 intron 2 growth hormone response element (IN2GHRE) histone methylation of key lysines and DNA methylation.	Lysine	166-173	insulin-like growth factor 1	Rattus norvegicus	82-87
32544411-6	2020	It was determined that OXL-induced endoplasmic reticulum stress (ERS) decreased because LY administration reduced the expressions of activating transcription factor-6 (ATF6), glucose-regulated protein-78 (GRP78), pancreatic endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme-1 (IRE1).	Lysine	88-90	activating transcription factor 6	Rattus norvegicus	133-166
32544411-6	2020	It was determined that OXL-induced endoplasmic reticulum stress (ERS) decreased because LY administration reduced the expressions of activating transcription factor-6 (ATF6), glucose-regulated protein-78 (GRP78), pancreatic endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme-1 (IRE1).	Lysine	88-90	activating transcription factor 6	Rattus norvegicus	168-172
9774110-8	1998	Moreover, our data show that dCBP acetylates a conserved lysine in the Armadillo-binding domain of dTCF, and that this acetylation lowers the affinity of Armadillo binding to dTCF.	Lysine	57-63	armadillo	Drosophila melanogaster	71-80
25550471-0	2015	Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.	Lysine	86-92	SET domain containing 1A	Mus musculus	0-6
25550471-1	2015	SETD1A is a member of trithorax-related histone methyltransferases that methylate lysine 4 at histone H3 (H3K4).	Lysine	82-88	SET domain containing 1A	Mus musculus	0-6
25697176-4	2015	Rather, our genetic analyses suggest that in the presence of replicative stress H3 lysine 56 acetylation uncouples the Cdc45-Mcm2-7-GINS DNA helicase complex and DNA polymerases through the replisome component Ctf4.	Lysine	83-89	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	125-131
32538547-6	2020	RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples.	Lysine	80-86	synuclein alpha	Homo sapiens	21-30
32538547-6	2020	RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples.	Lysine	80-86	synuclein alpha	Homo sapiens	96-105
25852572-9	2015	Finally, the acetylation status of SIRT3 target lysine residues on MnSOD (K122) or oligomycin-sensitivity conferring protein (OSCP; K139) was not altered in either mouse or human skeletal muscle in response to acute exercise.	Lysine	48-54	sirtuin 3	Mus musculus	35-40
9774110-8	1998	Moreover, our data show that dCBP acetylates a conserved lysine in the Armadillo-binding domain of dTCF, and that this acetylation lowers the affinity of Armadillo binding to dTCF.	Lysine	57-63	armadillo	Drosophila melanogaster	154-163
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Lysine	210-216	general transcription factor IIA subunit 1	Homo sapiens	200-205
25892958-1	2015	Kdm3b is a Jumonji C domain-containing protein that demethylates mono- and di-methylated lysine 9 of histone H3 (H3K9me1 and H3K9me2).	Lysine	89-95	KDM3B lysine (K)-specific demethylase 3B	Mus musculus	0-5
9693119-3	1998	A recombinant receptor protein (ErbB3-K/M, in which K/M stands for Lys--&gt;Met amino acid substitution) containing an inactivating mutation in the putative ATP-binding site was also phosphorylated in response to HRG and EGF.	Lysine	67-70	erb-b2 receptor tyrosine kinase 3	Homo sapiens	32-37
25758227-7	2015	Our results also demonstrate that loss of Hdac1 and Hdac2 in the UB epithelium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383; these post-translational modifications are known to boost p53 stability and transcriptional activity.	Lysine	151-157	histone deacetylase 1	Mus musculus	42-47
25758227-7	2015	Our results also demonstrate that loss of Hdac1 and Hdac2 in the UB epithelium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383; these post-translational modifications are known to boost p53 stability and transcriptional activity.	Lysine	151-157	transformation related protein 53, pseudogene	Mus musculus	144-147
32878247-9	2020	A ubiquitination-defective mutant of SARAF with Lys-to-Arg substitutions in the CytD showed a slower degradation rate by half-life analysis.	Lysine	48-51	store-operated calcium entry associated regulatory factor	Homo sapiens	37-42
9694813-7	1998	Buried and solvent-exposed lysine residues were identified in bovine CRALBP by reductive methylation of the holoprotein followed by denaturation and reaction with [3H]acetic anhydride.	Lysine	27-33	retinaldehyde binding protein 1	Bos taurus	69-75
32929358-6	2020	Results: HRG directly interacted with TNFR1 and stabilized TNFR1 protein by decreasing the Lys(K)-48 ubiquitination mediated-degradation.	Lysine	91-94	TNF receptor superfamily member 1A	Homo sapiens	38-43
32929358-6	2020	Results: HRG directly interacted with TNFR1 and stabilized TNFR1 protein by decreasing the Lys(K)-48 ubiquitination mediated-degradation.	Lysine	91-94	TNF receptor superfamily member 1A	Homo sapiens	59-64
32929358-7	2020	The formation of TNFR1-complex II was prompted by HRG overexpression via upregulating Lys(K)-63 ubiquitination of TNFR1.	Lysine	86-89	TNF receptor superfamily member 1A	Homo sapiens	17-22
25568349-3	2015	In the current study, using ectopic expression and ex vivo differentiation of CD34(+) hematopoietic progenitor cells, we demonstrate that C/EBPepsilon is acetylated, which was confirmed by mass spectrometry analysis, identifying 4 acetylated lysines in 3 distinct functional domains.	Lysine	242-249	CCAAT enhancer binding protein epsilon	Homo sapiens	138-150
32929358-7	2020	The formation of TNFR1-complex II was prompted by HRG overexpression via upregulating Lys(K)-63 ubiquitination of TNFR1.	Lysine	86-89	TNF receptor superfamily member 1A	Homo sapiens	114-119
9692954-8	1998	PEDF chemically modified on lysine residues by biotinylation lost its capacity for interacting with heparin, implicating the involvement of PEDF lysine residues in heparin binding.	Lysine	28-34	serpin family F member 1	Homo sapiens	0-4
25306337-0	2015	The solubility and conformational characteristics of porcine myosin as affected by the presence of L-lysine and L-histidine.	Lysine	99-107	myosin heavy chain 14	Homo sapiens	61-67
25306337-2	2015	The solubility of myosin was increased in the presence of L-his and/or L-lys in all ionic strength solutions used.	Lysine	71-76	myosin heavy chain 14	Homo sapiens	18-24
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Lysine	51-56	myosin heavy chain 14	Homo sapiens	91-97
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Lysine	51-56	myosin heavy chain 14	Homo sapiens	283-289
32702237-8	2020	Of note, modification of lysine residues on either proMMP-1 or TIMP-1 ablated the ability of the MMP-1/TIMP-1 complex to bind to LRP1.	Lysine	25-31	matrix metallopeptidase 1	Homo sapiens	54-59
9692954-8	1998	PEDF chemically modified on lysine residues by biotinylation lost its capacity for interacting with heparin, implicating the involvement of PEDF lysine residues in heparin binding.	Lysine	145-151	serpin family F member 1	Homo sapiens	0-4
25306337-5	2015	These results demonstrate that the introduction of L-lys and L-his causes the unfolding of myosin, resulting in loss of alpha-helical structure, which is followed by increases in random coils, beta-turns and beta-sheets, which exposes buried hydrophobic and sulphydryl groups to the myosin surface, ultimately increasing the solubility of porcine myosin.	Lysine	51-56	myosin heavy chain 14	Homo sapiens	283-289
9692954-8	1998	PEDF chemically modified on lysine residues by biotinylation lost its capacity for interacting with heparin, implicating the involvement of PEDF lysine residues in heparin binding.	Lysine	145-151	serpin family F member 1	Homo sapiens	140-144
9692954-11	1998	Homology modeling of PEDF based on the X-ray crystal structures of antithrombin III and ovalbumin shows a region at the center of beta-sheet A-strands 2 and 3- and helix F that has a basic electrostatic surface potential and is densely populated with lysines exposed to the surface (K134, K137, K189, K191, H212, and K214) that are available to interact with various glycosaminoglycans/polyanions.	Lysine	251-258	serpin family F member 1	Homo sapiens	21-25
32561529-4	2020	ATF3 was highly induced by combined PDI and HDACi treatment as a result of increased acetylation of key histone lysine residues (H3K27-ac, H3K18-ac) flanking the ATF3 promoter region.	Lysine	112-118	activating transcription factor 3	Homo sapiens	0-4
32561529-4	2020	ATF3 was highly induced by combined PDI and HDACi treatment as a result of increased acetylation of key histone lysine residues (H3K27-ac, H3K18-ac) flanking the ATF3 promoter region.	Lysine	112-118	activating transcription factor 3	Homo sapiens	162-166
25546421-11	2015	In both orientations, the ligand-binding module interferes with binding of beta2GPI to anionic phospholipids; however, it interacts with two different but overlapping sets of lysine residues in beta2GPI-DV, depending on the orientation.	Lysine	175-181	apolipoprotein H	Homo sapiens	75-83
25546421-11	2015	In both orientations, the ligand-binding module interferes with binding of beta2GPI to anionic phospholipids; however, it interacts with two different but overlapping sets of lysine residues in beta2GPI-DV, depending on the orientation.	Lysine	175-181	apolipoprotein H	Homo sapiens	194-205
9668555-1	1998	Heterozygotes and homozygotes for HbE (beta 26, GAG-AAG, Glu-Lys) are microcytic, minimally anemic, and asymptomatic.	Lysine	61-64	hemoglobin subunit epsilon 1	Homo sapiens	34-37
25448633-1	2015	Cephalosporin C acylase (CCA), an important industrial enzyme for the production of 7-aminocephalosporanic acid, has very limited and scattered surface lysine residues.	Lysine	152-158	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	Mus musculus	25-28
32559753-6	2020	Enzymes are covalently tethered to the capsid protein of TMV by the N- and C-terminal addition of lysine-rich assembly domains which react with surface exposed glutamine residues on the capsid surfaces; the lysine/glutamine linkages are mediated by a microbial transglutaminase (mTG).	Lysine	98-104	microbial transglutaminase	None	251-277
9618474-1	1998	Histone H4 can be acetylated at N-terminal lysines K5, K8, K12, and K16, but newly synthesized H4 is diacetylated at K5/K12 in diverse organisms.	Lysine	43-50	histone H4	Saccharomyces cerevisiae S288C	0-10
32544088-3	2020	Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal (BET) family of proteins that function as epigenetic "readers" of acetylated lysine groups on histones.	Lysine	166-172	bromodomain containing 4	Mus musculus	0-32
32544088-3	2020	Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal (BET) family of proteins that function as epigenetic "readers" of acetylated lysine groups on histones.	Lysine	166-172	bromodomain containing 4	Mus musculus	34-38
25472959-8	2015	Patients with T2DM showed Set7-dependent monomethylation of lysine 4 of histone 3 on NF-kB p65 promoter.	Lysine	60-66	KMT5A pseudogene 1	Homo sapiens	26-30
25472959-11	2015	In human aortic endothelial cells, silencing of Set7 prevented monomethylation of lysine 4 of histone 3 and abolished NF-kB-dependent oxidant and inflammatory signaling.	Lysine	82-88	KMT5A pseudogene 1	Homo sapiens	48-52
25315187-8	2015	Further mass spectrometry analysis indicated that both ACAT1 and MnSOD had characterized acetylation at lysine residues, which is the first time to identify acetylation of ACAT1 and MnSOD in ccRCC.	Lysine	104-110	acetyl-CoA acetyltransferase 1	Homo sapiens	55-60
25315187-8	2015	Further mass spectrometry analysis indicated that both ACAT1 and MnSOD had characterized acetylation at lysine residues, which is the first time to identify acetylation of ACAT1 and MnSOD in ccRCC.	Lysine	104-110	acetyl-CoA acetyltransferase 1	Homo sapiens	172-177
32679077-4	2020	OTUD3 directly hydrolyzes lysine 63 (Lys63)-linked polyubiquitination of MAVS and thus shuts off innate antiviral immune response.	Lysine	26-32	mitochondrial antiviral signaling protein	Homo sapiens	73-77
9660300-1	1998	The Asian flush reaction is known to result from a lysine for glutamine substitution in the aldehyde dehydrogenase 2 (ALDH2) gene.	Lysine	51-57	aldehyde dehydrogenase 2 family member	Homo sapiens	92-116
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	interleukin 17 receptor B	Homo sapiens	130-134
32634241-2	2020	Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on the histone methyltransferase DOT1L, which methylates histone 3 lysine 79 (H3K79).	Lysine	190-196	lysine methyltransferase 2A	Homo sapiens	40-45
9660300-1	1998	The Asian flush reaction is known to result from a lysine for glutamine substitution in the aldehyde dehydrogenase 2 (ALDH2) gene.	Lysine	51-57	aldehyde dehydrogenase 2 family member	Homo sapiens	118-123
32634241-2	2020	Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on the histone methyltransferase DOT1L, which methylates histone 3 lysine 79 (H3K79).	Lysine	190-196	lysine methyltransferase 2A	Homo sapiens	58-63
9601051-6	1998	Finally, it is demonstrated that inhibition of Lp(a) assembly by proline, lysine, and lysine analogues, as well as by arginine and phenylalanine, is due to their ability to inhibit noncovalent association of apo(a) and apoB-100 and that these compounds directly exert their effects primarily through interactions with sequences contained within apo(a) kringle IV types 6-8.	Lysine	74-80	lipoprotein(a)	Homo sapiens	47-52
32668765-1	2020	KMT2D encodes a methyltransferase responsible for histone 3 lysine 4 (H3K4) mono-/di-methylation, an epigenetic mark correlated with active transcription.	Lysine	60-66	lysine methyltransferase 2D	Homo sapiens	0-5
25476551-6	2015	The results also show that Sirt2 can regulate the acylation of lysine residues, of proteins, with fatty acids within cells.	Lysine	63-69	sirtuin 2	Homo sapiens	27-32
9601051-6	1998	Finally, it is demonstrated that inhibition of Lp(a) assembly by proline, lysine, and lysine analogues, as well as by arginine and phenylalanine, is due to their ability to inhibit noncovalent association of apo(a) and apoB-100 and that these compounds directly exert their effects primarily through interactions with sequences contained within apo(a) kringle IV types 6-8.	Lysine	86-92	lipoprotein(a)	Homo sapiens	47-52
25962702-1	2015	Sirtuin 3 (SIRT3) is a mitochondrial NAD(+)-dependent deacetylase that regulates energy metabolic enzymes by reversible protein lysine acetylation in various extracardiac tissues.	Lysine	128-134	sirtuin 3	Mus musculus	0-9
9593830-0	1998	Enzymatic and chemical modifications of lipoprotein(a) selectively alter its lysine-binding functions.	Lysine	77-83	lipoprotein(a)	Homo sapiens	40-54
25962702-1	2015	Sirtuin 3 (SIRT3) is a mitochondrial NAD(+)-dependent deacetylase that regulates energy metabolic enzymes by reversible protein lysine acetylation in various extracardiac tissues.	Lysine	128-134	sirtuin 3	Mus musculus	11-16
24947323-0	2015	The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE).	Lysine	99-102	F-box protein 7	Homo sapiens	18-23
24947323-5	2015	We found that FBXO7 interacts with NRAGE and mediates Lys-63-linked poly-ubiquitination of NRAGE in mammalian cells.	Lysine	54-57	F-box protein 7	Homo sapiens	14-19
32711437-12	2020	Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively).	Lysine	84-87	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	116-119
32605139-2	2020	eIF5A activity requires a unique and functionally essential post-translational modification, the change of a lysine to hypusine.	Lysine	109-115	eukaryotic translation initiation factor 5A	Homo sapiens	0-5
25790176-4	2015	Candidate screening revealed that the acetylation status of lysine 68 on superoxide dismutase (SOD2K68) is dependent on Sirt3 deacetylase activity in oocytes, and acetylation-mimetic mutant SOD2K68Q results in almost threefold increase in intracellular ROS.	Lysine	60-66	sirtuin 3	Mus musculus	120-125
9593830-1	1998	The pathogenicity of lipoprotein(a) [Lp(a)] as a risk factor for cardiovascular disease may depend upon its lysine binding sites (LBS) which impart unique functions to Lp(a) not shared with low density lipoprotein.	Lysine	108-114	lipoprotein(a)	Homo sapiens	21-35
9593830-1	1998	The pathogenicity of lipoprotein(a) [Lp(a)] as a risk factor for cardiovascular disease may depend upon its lysine binding sites (LBS) which impart unique functions to Lp(a) not shared with low density lipoprotein.	Lysine	108-114	lipoprotein(a)	Homo sapiens	37-42
25895136-13	2015	Intriguingly, mutating all 10 SUMO acceptor lysines did not reduce c-Myc SUMOylation, suggesting that SUMO acceptor lysines in c-Myc act promiscuously.	Lysine	116-123	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	127-132
9593830-1	1998	The pathogenicity of lipoprotein(a) [Lp(a)] as a risk factor for cardiovascular disease may depend upon its lysine binding sites (LBS) which impart unique functions to Lp(a) not shared with low density lipoprotein.	Lysine	108-114	lipoprotein(a)	Homo sapiens	168-173
9593830-3	1998	In the LBS-Lp(a) immunoassay, minimal changes in the LBS activity of Lp(a) were observed after modification with lipoprotein lipase, sphingomyelinase, or phospholipase C. In contrast, a significant (p&lt;0.003) increase in the LBS activity of Lp(a) occurred after phospholipase A2 (PLA2) treatment, and this increase was confirmed using the lysine-Sepharose bead assay.	Lysine	341-347	lipoprotein(a)	Homo sapiens	69-74
9593830-3	1998	In the LBS-Lp(a) immunoassay, minimal changes in the LBS activity of Lp(a) were observed after modification with lipoprotein lipase, sphingomyelinase, or phospholipase C. In contrast, a significant (p&lt;0.003) increase in the LBS activity of Lp(a) occurred after phospholipase A2 (PLA2) treatment, and this increase was confirmed using the lysine-Sepharose bead assay.	Lysine	341-347	lipoprotein(a)	Homo sapiens	69-74
32497171-2	2020	The functionality of bovine rhodopsin was determined following treatment with sulfosuccinimidyl 4-(N maleimidomethyl)cyclohexane-1-carboxylate (sulfo-SMCC), a bifunctional reagent capable of forming covalent cross-links between suitable placed lysines and cysteines.	Lysine	244-251	rhodopsin	Bos taurus	28-37
9572863-10	1998	These results indicate a specific role of Lys-72 of pol beta in the dRP excision during base excision repair.	Lysine	42-45	DNA polymerase beta	Homo sapiens	52-60
32497171-9	2020	Structural analysis of the rhodopsin three-dimensional structure suggested that the following lysine and cysteine pairs: Lys66/Lys67 and Cys316, Cys140 and Lys141, Cys140 and Lys248, Lys311 and Cys316, and/or Cys316 and Lys325 are potential candidates to generate intramolecular cross-links in the protein.	Lysine	94-100	rhodopsin	Bos taurus	27-36
25612011-3	2015	Using a rat model for developmental reprogramming of susceptibility to prostate carcinogenesis, we identified, by RNA-seq, that Scgb2a1 is significantly upregulated (&gt;100-fold) in the prostate of adult rats neonatally exposed to bisphenol A (BPA), with increased gene expression confirmed by quantitative RT-PCR and chromatin immunoprecipitation for histone H3 lysine 9 acetylation.	Lysine	364-370	secretoglobin, family 2A, member 2	Rattus norvegicus	128-135
26111032-2	2015	Initially thought to be an irreversible process, histone methylation is now known to be reversed by two families of proteins containing over 30 members that act to remove methyl groups from specific lysine residues present in the tails of histone H3 and histone H4.	Lysine	199-205	H4 clustered histone 6	Homo sapiens	254-264
9560319-4	1998	Mutation of this residue to Leu, Ile, Lys, Glu or Phe in the human GnRH receptor did not result in constitutive activity and instead led to complete uncoupling of the receptor (failure to support GnRH-stimulated inositol phosphate production).	Lysine	38-41	gonadotropin releasing hormone receptor	Homo sapiens	67-80
9560319-4	1998	Mutation of this residue to Leu, Ile, Lys, Glu or Phe in the human GnRH receptor did not result in constitutive activity and instead led to complete uncoupling of the receptor (failure to support GnRH-stimulated inositol phosphate production).	Lysine	38-41	gonadotropin releasing hormone 1	Homo sapiens	67-71
33367258-3	2020	Here, we show that SEU is a substrate of SUMO1, and that substitution of four conserved lysine residues disrupts the SUMOylation of SEU, impairs its function in photo- and thermomorphogenesis, and enhances its interaction with PHYTOCHROME-INTERACTING FACTOR 4 transcription factors.	Lysine	88-94	SEUSS transcriptional co-regulator	Arabidopsis thaliana	132-135
9556608-6	1998	Both brain and recombinant neuropsin had amidolytic activities cleaving Arg-X and Lys-X bonds in the synthetic chromogenic substrates, and the highest specific activity was found against Boc-Val-Pro-Arg-4-methylcoumaryl-7-amide.	Lysine	82-85	opsin 5	Mus musculus	27-36
32338452-4	2020	Herein, a novel nanocomlex consisting of dendrigraft poly-l-lysine (DGL)-loaded miR-1 inhibitor as the core to decrease apoptosis of cardiomyocytes and LMWH as the shell to overcome microvascular obstruction of the infarct area is developed.	Lysine	53-66	fibronectin type III and SPRY domain containing 1	Homo sapiens	80-85
25238203-9	2015	ASH1L and MLL1, which belong to the Trithorax group (TrxG) proteins and are major regulators of Homeobox gene expression, maintain active target gene transcription by histone 3 lysine 4 methylation.	Lysine	177-183	lysine methyltransferase 2A	Homo sapiens	10-14
25491103-1	2015	Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways.	Lysine	15-18	bone morphogenetic protein 1	Homo sapiens	208-211
9749372-3	1998	The X-ray structure of the active site of COMT suggests that the methylation involves a lysine as a general base.	Lysine	88-94	catechol-O-methyltransferase	Homo sapiens	42-46
25505145-4	2015	One level of control is provided by ubiquitination of the homotrimeric DNA clamp PCNA at lysine residue 164 (PCNA-Ub).	Lysine	89-95	proliferating cell nuclear antigen	Homo sapiens	81-85
25505145-4	2015	One level of control is provided by ubiquitination of the homotrimeric DNA clamp PCNA at lysine residue 164 (PCNA-Ub).	Lysine	89-95	proliferating cell nuclear antigen	Homo sapiens	109-113
31099089-7	2020	Consistently, chromatin immunoprecipitation results confirm that PPD2 and LHP1 are co-enriched at the promoter region of their targets such as D3-TYPE CYCLINS and HIGH MOBILITY GROUP A, which are up-regulated in ppd2, lhp1 and ppd2 lhp1 mutants, and that PPDs mediate repressive histone 3 lysine-27 trimethylation at these loci.	Lysine	289-295	like heterochromatin protein (LHP1)	Arabidopsis thaliana	74-78
9572144-8	1998	A deletion of RPD3 or SIN3, but not of the related histone-deacetylase gene HDA1, results in increased acetylation of the lysine 5 residue of H4 in the promoters of the UME6-regulated INO1, IME2 and SPO13 genes.	Lysine	122-128	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	169-173
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	transformed mouse 3T3 cell double minute 2	Mus musculus	113-117
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	transformation related protein 53, pseudogene	Mus musculus	124-127
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	transformed mouse 3T3 cell double minute 2	Mus musculus	172-176
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Lysine	74-77	metallothionein 2A	Homo sapiens	37-41
9525883-6	1998	The AP lyase activity of T4 DNA ligase is inhibited in the presence of ATP, suggesting that the adenylated lysine residue is part of the active site for both the ligase and lyase activities.	Lysine	107-113	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-12
25677767-5	2015	In search of higher agonist potency, two lysine and two aspartate residues were strategically incorporated into the receptor-binding C-terminus of the nociceptin sequence and two Lys(i) Asp(i+4) side chain-side chain condensations were used to generate lactam cross-links that constrained nociceptin into a highly stable alpha-helix in water.	Lysine	41-47	prepronociceptin	Rattus norvegicus	151-161
9560400-5	1998	The z1 lesion alters a lysine residue located between the N-terminal DNA-binding domain and the C-terminal hydrophobic repeats involved in Zeste self-interactions.	Lysine	23-29	zeste	Drosophila melanogaster	139-144
32596350-6	2020	lncRNA EZR-AS1 was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription.	Lysine	105-111	EZR antisense RNA 1	Homo sapiens	7-14
32596350-6	2020	lncRNA EZR-AS1 was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription.	Lysine	105-111	ezrin	Homo sapiens	7-10
25323450-2	2014	Its function relies on two ligand-binding surfaces of Pygo"s PHD finger that anchor the histone H3 tail methylated at lysine 4 (H3K4me) with assistance from the BCL9 HD1 domain.	Lysine	118-124	BCL9 transcription coactivator	Homo sapiens	161-165
9516482-3	1998	In the present study, we analyzed the effects of mutating the Glu at position 31 of the c-Ha-Ras protein to Asp, Ala, Arg, and Lys on the interactions with Raf-1 and RalGDS.	Lysine	127-130	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	156-161
25218134-5	2014	In addition, we also employed genetic approaches by ablating both the eIF5A protein itself and DHS, the rate limiting enzyme catalyzing the conversion of lysine to hypusine.	Lysine	154-160	eukaryotic translation initiation factor 5A	Homo sapiens	70-75
32478258-8	2020	A central alanine-to-lysine substitution in each hydrophobic fragment completely eliminated the peptides" amyloidogenic property, and alanine-to-lysine substitutions at corresponding sites in full-length alpha-synuclein also decreased the protein"s amyloidogenic potency.	Lysine	145-151	synuclein alpha	Homo sapiens	204-219
9516482-3	1998	In the present study, we analyzed the effects of mutating the Glu at position 31 of the c-Ha-Ras protein to Asp, Ala, Arg, and Lys on the interactions with Raf-1 and RalGDS.	Lysine	127-130	ral guanine nucleotide dissociation stimulator	Homo sapiens	166-172
32249212-0	2020	SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation.	Lysine	49-52	zinc finger homeobox 3	Homo sapiens	40-45
9516482-4	1998	The Ras-binding domain (RBD) of Raf-1 binds the E31R and E31K Ras mutants less tightly than the wild-type, E31A, and E31D Ras proteins; the introduction of the positively charged Lys or Arg residue at position 31 specifically impairs the binding of Ras with the Raf-1 RBD.	Lysine	179-182	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	32-37
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	72-76
9516482-4	1998	The Ras-binding domain (RBD) of Raf-1 binds the E31R and E31K Ras mutants less tightly than the wild-type, E31A, and E31D Ras proteins; the introduction of the positively charged Lys or Arg residue at position 31 specifically impairs the binding of Ras with the Raf-1 RBD.	Lysine	179-182	zinc fingers and homeoboxes 2	Homo sapiens	32-35
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	84-89
9521725-9	1998	(1996) Biochemistry 35, 7032-7040] suggests potential binding between the threonine-47 in a conserved cis-peptide loop and PPi whereas human HGPRTase has lysine-68 [Eads et al.	Lysine	154-160	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	141-149
25063569-3	2014	In eukaryotic organisms, a single Ub is attached to specific lysine residues of histones H2A and H2B in a modification that, unlike many other forms of ubiquitination in the cell, does not signal degradation.	Lysine	61-67	H2B clustered histone 21	Homo sapiens	97-100
32139118-5	2020	In this report, we examined MLL2 (KMT2D), a histone-lysine methyltransferase that catalyzes histone H3 lysine 4 methylation (H3K4me).	Lysine	52-58	lysine methyltransferase 2D	Homo sapiens	28-32
32139118-5	2020	In this report, we examined MLL2 (KMT2D), a histone-lysine methyltransferase that catalyzes histone H3 lysine 4 methylation (H3K4me).	Lysine	52-58	lysine methyltransferase 2D	Homo sapiens	34-39
32139118-5	2020	In this report, we examined MLL2 (KMT2D), a histone-lysine methyltransferase that catalyzes histone H3 lysine 4 methylation (H3K4me).	Lysine	103-109	lysine methyltransferase 2D	Homo sapiens	28-32
32139118-5	2020	In this report, we examined MLL2 (KMT2D), a histone-lysine methyltransferase that catalyzes histone H3 lysine 4 methylation (H3K4me).	Lysine	103-109	lysine methyltransferase 2D	Homo sapiens	34-39
9521733-4	1998	Based on the crystal structure of human HGPRTase, protonation/deprotonation is likely to occur at N7 of the purine ring, and Lys 165 or Asp 137 are each candidates for the general base/acid.	Lysine	125-128	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	40-48
9531424-2	1998	This sequence was confirmed by chemical synthesis and shows four amino acid substitutions (Arg1 --&gt; Lys,Lys3 --&gt; Arg,Gln5 --&gt; Asp and Phe8 --&gt; Tyr) compared with substance P.	Lysine	103-106	arginase 1	Homo sapiens	91-95
32323737-1	2020	[Su(var)3-9, enhancer of zeste, Trithorax] domain-containing protein 7 (SETD7) is a protein lysine methyltransferase that methylates both histone H3K4 and non-histone proteins, such as transcription factors.	Lysine	92-98	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	72-77
25469049-11	2014	In terms of the XPD Lys751Gln polymorphism, a significant association with EC susceptibility was found under the recessive model (Gln/Gln vs Lys/Gln+Lys/Lys: OR = 1.21, 95%CI: 1.02-1.43, P = 0.03).	Lysine	20-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-11	2014	In terms of the XPD Lys751Gln polymorphism, a significant association with EC susceptibility was found under the recessive model (Gln/Gln vs Lys/Gln+Lys/Lys: OR = 1.21, 95%CI: 1.02-1.43, P = 0.03).	Lysine	141-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
25469049-11	2014	In terms of the XPD Lys751Gln polymorphism, a significant association with EC susceptibility was found under the recessive model (Gln/Gln vs Lys/Gln+Lys/Lys: OR = 1.21, 95%CI: 1.02-1.43, P = 0.03).	Lysine	141-144	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
32355204-0	2020	Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer.	Lysine	79-85	BCL3 transcription coactivator	Homo sapiens	0-5
32355204-0	2020	Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer.	Lysine	79-85	catenin beta 1	Homo sapiens	63-75
9442102-5	1998	In contrast to most ubiquitinated proteins, only a single lysine residue (K526) in RanGAP1 can serve as the acceptor site for modification by SUMO-1.	Lysine	58-64	small ubiquitin like modifier 1	Homo sapiens	142-148
32355204-6	2020	Interestingly, Wnt3a increases the level and nuclear translocation of Bcl-3, which binds directly to beta-catenin and enhances the acetylation of beta-catenin at lysine 49 (Ac-K49-beta-catenin) and transcriptional activity.	Lysine	162-168	BCL3 transcription coactivator	Homo sapiens	70-75
32355204-6	2020	Interestingly, Wnt3a increases the level and nuclear translocation of Bcl-3, which binds directly to beta-catenin and enhances the acetylation of beta-catenin at lysine 49 (Ac-K49-beta-catenin) and transcriptional activity.	Lysine	162-168	catenin beta 1	Homo sapiens	146-158
25419660-0	2014	Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.	Lysine	29-35	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	0-19
25419660-2	2014	The LH3 has been shown to modify the lysine residues both in collagens and also in some collagenous proteins.	Lysine	37-43	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	4-7
25419660-4	2014	Furthermore, loss of the terminal glucose units on the derivatized lysine residues in mouse embryonic fibroblasts lacking the LH3 protein leads to defective disulphide bonding and oligomerization of rat MBL-A, with a decrease in the proportion of the larger functional MBL oligomers.	Lysine	67-73	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	126-129
25490674-11	2014	A small propargyl group is transferred from the cofactor analogue SeAdoYn to the protein by the histone H3 lysine 4 (H3K4) MTase Set7/9 followed by click labeling of the alkynylated histone H3 with TAMRA azide.	Lysine	107-113	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	129-135
32355204-6	2020	Interestingly, Wnt3a increases the level and nuclear translocation of Bcl-3, which binds directly to beta-catenin and enhances the acetylation of beta-catenin at lysine 49 (Ac-K49-beta-catenin) and transcriptional activity.	Lysine	162-168	catenin beta 1	Homo sapiens	146-158
9818478-2	1998	This mutation brings about a substitution of glutamic acid to lysine in the cytochrome P4501B1 molecule, and has been shown to be responsible, in homozygous form, for a severe and prognostically unfavourable form of primary congenital glaucoma (PCG).	Lysine	62-68	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	87-94
32094223-5	2020	Using MS-based analysis in HEK293 cells, we identified six lysine residues (Lys-556, -1155, -1230, -1465, -1475, and -1528) as ubiquitination sites in IQGAP1.	Lysine	59-65	IQ motif containing GTPase activating protein 1	Homo sapiens	151-157
32094223-5	2020	Using MS-based analysis in HEK293 cells, we identified six lysine residues (Lys-556, -1155, -1230, -1465, -1475, and -1528) as ubiquitination sites in IQGAP1.	Lysine	76-79	IQ motif containing GTPase activating protein 1	Homo sapiens	151-157
32094223-6	2020	To elucidate the biological consequences of IQGAP1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of these residues, Lys-1155 and Lys-1230, in the GAP-related domain of IQGAP1 (termed IQGAP1 GRD-2K) reduces its ubiquitination.	Lysine	94-101	IQ motif containing GTPase activating protein 1	Homo sapiens	44-50
32094223-6	2020	To elucidate the biological consequences of IQGAP1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of these residues, Lys-1155 and Lys-1230, in the GAP-related domain of IQGAP1 (termed IQGAP1 GRD-2K) reduces its ubiquitination.	Lysine	162-165	IQ motif containing GTPase activating protein 1	Homo sapiens	44-50
25014164-4	2014	Here we show that the histone 3 lysine 4- and lysine 36-specific methyltransferase Smyd2 acts as an endogenous antagonistic player of p53-dependent cardiomyocyte apoptosis.	Lysine	32-38	SET and MYND domain containing 2	Homo sapiens	83-88
25014164-4	2014	Here we show that the histone 3 lysine 4- and lysine 36-specific methyltransferase Smyd2 acts as an endogenous antagonistic player of p53-dependent cardiomyocyte apoptosis.	Lysine	46-52	SET and MYND domain containing 2	Homo sapiens	83-88
32094223-6	2020	To elucidate the biological consequences of IQGAP1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of these residues, Lys-1155 and Lys-1230, in the GAP-related domain of IQGAP1 (termed IQGAP1 GRD-2K) reduces its ubiquitination.	Lysine	175-178	IQ motif containing GTPase activating protein 1	Homo sapiens	44-50
9407092-11	1997	Taken together, these data reveal a second region of interaction with the p75 receptor in NGF with the positively charged residues Lys-74 and His-75 as candidate points of contact.	Lysine	131-134	nerve growth factor receptor	Rattus norvegicus	74-77
32265326-9	2020	CRL4 ligases catalyze different patterns of lysine ubiquitination on PB2.	Lysine	44-50	interleukin 17 receptor B	Homo sapiens	0-4
25130613-6	2014	A complement activation assay combined with mass spectrometry analysis revealed a highly significant inverse correlation between carbamylation of several key lysine residues within the hinge region and N-terminus of the CH2 domain and the proper binding of C1q to human IgG1 followed by subsequent complement activation.	Lysine	158-164	complement C1q A chain	Homo sapiens	257-260
25356590-2	2014	The histone methyltransferase Set1, a component of the Set1C/COMPASS complex, catalyzes the methylation at lysine 4 of histone H3 (H3K4me), a hallmark of euchromatin.	Lysine	107-113	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	30-34
32265326-10	2020	Recombinant viruses mutated in the targeted lysines showed attenuated viral production, suggesting that CRL4-mediated ubiquitination of PB2 contributes to IAV infection.	Lysine	44-51	interleukin 17 receptor B	Homo sapiens	104-108
9548475-7	1997	Thus, the carboxyl-terminal five amino acids, Lys-Tyr-Glu-Gly-Lys (KYEGK), of the beta1 integrin cytoplasmic domain are critical for the coordinate tyrosine phosphorylation of three non-FAK substrates in human T cells.	Lysine	46-49	protein tyrosine kinase 2	Homo sapiens	186-189
25285631-0	2014	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.	Lysine	57-63	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	48-53
25285631-0	2014	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.	Lysine	57-63	sirtuin 2	Homo sapiens	71-76
32265459-6	2020	Met-predictor was tested on two independent test sets, where the addition of structure model-based features improved AUC from 0.611 and 0.520 to 0.655 and 0.566 for lysine and from 0.723 and 0.640 to 0.734 and 0.643 for arginine.	Lysine	165-171	SAFB like transcription modulator	Homo sapiens	0-3
9548475-7	1997	Thus, the carboxyl-terminal five amino acids, Lys-Tyr-Glu-Gly-Lys (KYEGK), of the beta1 integrin cytoplasmic domain are critical for the coordinate tyrosine phosphorylation of three non-FAK substrates in human T cells.	Lysine	62-65	protein tyrosine kinase 2	Homo sapiens	186-189
25285631-5	2014	Here, we investigated whether SIRT2 deacetylates BubR1, which is a core component of the SAC; acetylation of BubR1 at lysine 250 (K250) during prometaphase inhibits its APC/C-dependent proteolysis and thus regulates timing in anaphase entry.	Lysine	118-124	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	109-114
9440041-3	1997	To obtain the analogue with the photolabel at Arg 1, SP was first reacted with N-hydroxysuccinimide p-hydroxyphenylpropionate, the Lys 3-modified derivative was isolated by reversed-phase high-performance liquid chromatography (HPLC), reacted with N-hydroxysuccinimide p-benzoylbenzoate and purified by HPLC.	Lysine	131-134	arginase 1	Rattus norvegicus	46-51
24166499-3	2014	Here we report that merlin can be sumoylated on Lysine residue (K76) in vitro and in vivo.	Lysine	48-54	keratin 76	Homo sapiens	64-67
24594358-4	2014	Here we present the crystal structure of SMYD2 in complex with a target lysine (Lys266)-containing ERalpha peptide.	Lysine	72-78	SET and MYND domain containing 2	Homo sapiens	41-46
24594358-5	2014	The structure reveals that ERalpha binds SMYD2 in a U-shaped conformation with the binding specificity determined mainly by residues C-terminal to the target lysine.	Lysine	158-164	SET and MYND domain containing 2	Homo sapiens	41-46
32249768-3	2020	Based on the finding that nuclear PTEN is more unstable than cytoplasmic PTEN, here we identify that F-box only protein 22 (FBXO22) induces ubiquitylation of nuclear but not cytoplasmic PTEN at lysine 221, which is responsible for the degradation of nuclear PTEN.	Lysine	194-200	F-box protein 22	Homo sapiens	101-122
32249768-3	2020	Based on the finding that nuclear PTEN is more unstable than cytoplasmic PTEN, here we identify that F-box only protein 22 (FBXO22) induces ubiquitylation of nuclear but not cytoplasmic PTEN at lysine 221, which is responsible for the degradation of nuclear PTEN.	Lysine	194-200	F-box protein 22	Homo sapiens	124-130
9356148-5	1997	These data, in combination with the known sequences of the two antibodies, suggested that nonspecific immobilization through one or more lysine residues close to or within the CDR2 region of the 11-1G10 VH domain was responsible for the reduced strength of the interaction with NC41.	Lysine	137-143	cerebellar degeneration related protein 2	Homo sapiens	176-180
32145688-3	2020	CRL activation requires neddylation, an enzymatic cascade transferring small ubiquitin-like protein NEDD8 to a conserved lysine residue on cullin proteins.	Lysine	121-127	CDK2 associated cullin domain 1	Homo sapiens	139-145
25195573-4	2014	Over-expression of SIRT2 or mutations at the acetylatable lysines of PGAM attenuates cancer cell proliferation with a concomitant decrease in PGAM activity.	Lysine	58-65	sirtuin 2	Homo sapiens	19-24
9520127-0	1997	Vascular accumulation of Lp(a): in vivo analysis of the role of lysine-binding sites using recombinant adenovirus.	Lysine	64-70	lipoprotein(a)	Homo sapiens	25-30
25086780-4	2014	We observed increased DNA methylation of the CpG island with enhanced recruitment of Dnmt3a, Dnmt3b and MeCP2 in the glut4 promoter region along with reduced acetylation of histone (H)2A.Z and H4 particularly at the H4.lysine (K)16 residue, which was predominantly mediated by histone deacetylase 4 (HDAC4).	Lysine	219-225	solute carrier family 2 member 4	Rattus norvegicus	117-122
9520127-3	1997	In these studies, we examined the properties of three forms of Lp(a) differing at postulated lysine-binding domains contained in the constituent apo(a).	Lysine	93-99	lipoprotein(a)	Homo sapiens	63-68
31953836-5	2020	Methylglyoxal was the major alpha-DC affected during storage, its relative content decreasing from 233.71 to 44.12 mug mL-1 in the glucose-lysine system.	Lysine	139-145	L1 cell adhesion molecule	Mus musculus	119-123
9520127-5	1997	By comparison of in vitro lysine-binding properties of these forms of Lp(a) with measurements of Lp(a) vascular accumulation in the mice, we have demonstrated that lysine-binding defective forms of Lp(a) have a diminished capacity for vascular accumulation in vivo.	Lysine	26-32	lipoprotein(a)	Homo sapiens	70-75
31953836-8	2020	The largest increases in 3-DG concentrations were observed in the maltose-lysine systems (24.94 to 35.74 mug mL-1 ).	Lysine	74-80	L1 cell adhesion molecule	Mus musculus	109-113
9520127-5	1997	By comparison of in vitro lysine-binding properties of these forms of Lp(a) with measurements of Lp(a) vascular accumulation in the mice, we have demonstrated that lysine-binding defective forms of Lp(a) have a diminished capacity for vascular accumulation in vivo.	Lysine	164-170	lipoprotein(a)	Homo sapiens	70-75
9520127-5	1997	By comparison of in vitro lysine-binding properties of these forms of Lp(a) with measurements of Lp(a) vascular accumulation in the mice, we have demonstrated that lysine-binding defective forms of Lp(a) have a diminished capacity for vascular accumulation in vivo.	Lysine	164-170	lipoprotein(a)	Homo sapiens	97-102
25127374-5	2014	In this work, we show by SUMOylation assays in COS-1 cells that the FOXA1 is modified at least in two of its three lysines embedded in SUMOylation consensus, K6 and K389, in proximity to its transactivation domains and K267 proximal to its DNA-binding domain.	Lysine	115-122	forkhead box A1	Homo sapiens	68-73
9520127-5	1997	By comparison of in vitro lysine-binding properties of these forms of Lp(a) with measurements of Lp(a) vascular accumulation in the mice, we have demonstrated that lysine-binding defective forms of Lp(a) have a diminished capacity for vascular accumulation in vivo.	Lysine	164-170	lipoprotein(a)	Homo sapiens	97-102
9431811-1	1997	We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the third alpha-helix of the homeodomain.	Lysine	210-216	Ptx1	Drosophila melanogaster	76-82
24905915-0	2014	Lysine residues at the first and second KTKEGV repeats mediate alpha-Synuclein binding to membrane phospholipids.	Lysine	0-6	synuclein alpha	Homo sapiens	63-78
31935506-2	2020	Studies have determined that pathogenic variants of the lysine-specific methyltransferase 2D (KMT2D) and lysine-specific demethylase 6A (KDM6A) genes are the major causes of KS.	Lysine	56-62	lysine methyltransferase 2D	Homo sapiens	94-99
9336452-2	1997	Three of these genes (mR-3, mR-4, mR-5) include complete open reading frames, encoding ribonucleases with eight cysteines and appropriately spaced histidines (His11 and His124) and lysine (Lys35) that are characteristic of this enlarging protein family; the fourth sequence encodes a non-functional pseudogene (mR-6P).	Lysine	181-187	eosinophil-associated, ribonuclease A family, member 3	Mus musculus	22-32
32218796-2	2020	Here we provide insight into the contribution of the histone lysine methyltransferase SET DOMAIN GROUP 8 (SDG8), implicated in histone H3 lysine 36 trimethylation (H3K36me3), in connection with RNA polymerase II (RNAPII) to enhance Arabidopsis immunity.	Lysine	61-67	histone-lysine N-methyltransferase	Arabidopsis thaliana	106-110
31794431-3	2020	Lysine acetyltransferase 8 (KAT8) is critical for acetylation of histone H4 at lysine 16 (H4K16), an evolutionarily conserved epigenetic mark.	Lysine	79-85	H4 clustered histone 6	Homo sapiens	65-75
25107905-1	2014	Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKbeta), the critical activating kinase in canonical (NFkappaB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma.	Lysine	27-33	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	45-50
25107905-1	2014	Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKbeta), the critical activating kinase in canonical (NFkappaB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma.	Lysine	27-33	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	70-77
25199838-6	2014	PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation.	Lysine	69-75	phosphatase and tensin homolog	Homo sapiens	0-4
9385634-0	1997	Oxidation of apolipoprotein(a) inhibits kringle-associated lysine binding: the loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site.	Lysine	59-65	lipoprotein(a)	Homo sapiens	13-30
25228803-2	2014	A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60.	Lysine	156-162	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	117-120
25228803-2	2014	A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60.	Lysine	156-162	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	195-198
31531877-8	2020	CBP immediately evoked KDM2B acetylation at lysine residue 765 in colon cancer cells.	Lysine	44-50	lysine demethylase 2B	Homo sapiens	23-28
9385634-0	1997	Oxidation of apolipoprotein(a) inhibits kringle-associated lysine binding: the loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site.	Lysine	165-171	lipoprotein(a)	Homo sapiens	13-30
9385634-2	1997	Lp(a) has been implicated in atherogenesis and thrombosis through the lysine binding site (LBS) affinity of its kringle domains.	Lysine	70-76	lipoprotein(a)	Homo sapiens	0-5
25127513-3	2014	Here, we show that isomerization of H3 at the alanine 15-proline 16 (A15-P16) peptide bond is influenced by lysine 14 (K14) and controls gene-specific K4me3 by balancing the actions of Jhd2, the K4me3 demethylase, and Spp1, a subunit of the Set1 K4 methyltransferase complex.	Lysine	108-114	keratin 14	Homo sapiens	119-122
9385634-4	1997	AAPH treatment caused a time-dependent decrease in the number of functional Lp(a) or r-apo(a) molecules capable of binding to fibrin or lysine-Sepharose and in the intrinsic protein fluorescence of both Lp(a) and r-apo(a).	Lysine	136-142	lipoprotein(a)	Homo sapiens	76-81
32115028-14	2020	High lysine concentration exhibited increased growth, upregulation of ghrelin in the liver, and downregulation of ghrelin in the intestines, and both adiponectin and leptin in the liver.	Lysine	5-11	leptin	Gallus gallus	166-172
9385645-2	1997	It is proposed that the mechanism for the in vitro methionylation of MetRS might be accounted for by the in situ covalent reaction of methionyl-adenylate with lysine side chains surrounding the active center of the enzyme, as well as by exchange of the label between donor and acceptor proteins.	Lysine	159-165	methionyl-tRNA synthetase 2, mitochondrial	Homo sapiens	69-74
32115028-16	2020	Expression of leptin was positively correlated with adiponectin in the hypothalamus and liver (P < 0.05), exhibiting satiety effects when the concentrations of lysine were low.	Lysine	160-166	leptin	Gallus gallus	14-20
9390441-0	1997	LHT1, a lysine- and histidine-specific amino acid transporter in arabidopsis.	Lysine	8-14	lysine histidine transporter 1	Arabidopsis thaliana	0-4
25029904-3	2014	Interestingly, a conserved lysine residue in eIF5A is post-translationally modified to hypusine and the corresponding lysine residue in EF-P from at least some bacteria is modified by the addition of a beta-lysine moiety.	Lysine	27-33	eukaryotic translation initiation factor 5A	Homo sapiens	45-50
25029904-3	2014	Interestingly, a conserved lysine residue in eIF5A is post-translationally modified to hypusine and the corresponding lysine residue in EF-P from at least some bacteria is modified by the addition of a beta-lysine moiety.	Lysine	118-124	eukaryotic translation initiation factor 5A	Homo sapiens	45-50
9390441-9	1997	Overall, LHT1 belongs to a new class of amino acid transporter that is specific for Lys and histidine, and, given its substrate specificity, it has significant promise as a tool for improving the Lys content of Lys-deficient grains.	Lysine	84-87	lysine histidine transporter 1	Arabidopsis thaliana	9-13
32184802-9	2020	PLOD1 and SETD7 genes were involved with lysine degradation in low feed efficient group in Landrace, while high feed efficient group pointed to genes underpinning valine, leucine, isoleucine degradation, and fatty acid elongation.	Lysine	41-47	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Sus scrofa	0-5
9390441-9	1997	Overall, LHT1 belongs to a new class of amino acid transporter that is specific for Lys and histidine, and, given its substrate specificity, it has significant promise as a tool for improving the Lys content of Lys-deficient grains.	Lysine	196-199	lysine histidine transporter 1	Arabidopsis thaliana	9-13
32103017-5	2020	This allows the lysine myrisotylation-demyristoylation cycle to couple to and promote the GTPase cycle of ARF6.	Lysine	16-22	ADP ribosylation factor 6	Homo sapiens	106-110
9390441-9	1997	Overall, LHT1 belongs to a new class of amino acid transporter that is specific for Lys and histidine, and, given its substrate specificity, it has significant promise as a tool for improving the Lys content of Lys-deficient grains.	Lysine	196-199	lysine histidine transporter 1	Arabidopsis thaliana	9-13
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-7
32101753-3	2020	NEDD4-1 undergoes lysine 29 (K29)-linked auto-ubiquitination at K1279 and serves as a scaffold for recruiting the ubiquitin-specific protease 13 (USP13) to form an NEDD4-1-USP13 deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy through removing the K48-linked poly-ubiquitin chains from VPS34 at K419.	Lysine	18-24	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	164-171
24996271-12	2014	The patterns of arterial concentrations combined with arterial-mammary venous concentration differences indicated that Lys, Leu, and Tyr were the first-limiting AA at 4 DIM with CTRL.	Lysine	119-122	CTRL	Bos taurus	178-182
18982486-8	1997	Significant enhancement in the nitric oxide production was investigated by the cotreatment of poly-L-lysine with antisense-TGFbeta.	Lysine	94-107	transforming growth factor, beta 1	Mus musculus	123-130
24880080-5	2014	Both in vitro and in vivo methyltransferase assays revealed that SMYD2 could methylate HSP90AB1 and mass spectrometry analysis indicated lysines 531 and 574 of HSP90AB1 to be methylated.	Lysine	137-144	SET and MYND domain containing 2	Homo sapiens	65-70
24880080-5	2014	Both in vitro and in vivo methyltransferase assays revealed that SMYD2 could methylate HSP90AB1 and mass spectrometry analysis indicated lysines 531 and 574 of HSP90AB1 to be methylated.	Lysine	137-144	heat shock protein 90 alpha family class B member 1	Homo sapiens	87-95
24880080-5	2014	Both in vitro and in vivo methyltransferase assays revealed that SMYD2 could methylate HSP90AB1 and mass spectrometry analysis indicated lysines 531 and 574 of HSP90AB1 to be methylated.	Lysine	137-144	heat shock protein 90 alpha family class B member 1	Homo sapiens	160-168
25148259-3	2014	Through simulating the dynamics of DAP12-NKG2C TM heterotrimer and point mutations, we demonstrated that a five-polar-residue motif including: 2 Asps and 2 Thrs in DAP12 dimer, as well as 1 Lys in NKG2C TM plays an important role in the assembly structure of the DAP12-NKG2C TM heterotrimer.	Lysine	190-193	transmembrane immune signaling adaptor TYROBP	Homo sapiens	35-40
32078691-5	2020	The most frequent mutation in DIPG is a lysine to methionine (K27M) mutation that occurs on H3F3A and HIST1H3B/C, genes encoding histone variants.	Lysine	40-46	H3.3 histone A	Homo sapiens	92-97
9298986-3	1997	The 26S, but not the 20S proteasome, digested recombinant 49-kD cyclin B at lysine 57 (K57), producing a 42-kD truncated form.	Lysine	76-82	proliferating cell nuclear antigen S homeolog	Xenopus laevis	64-70
31320749-6	2020	We further found that PVT1 serves as a scaffold for the chromatin modification factor KAT2A, which mediates histone 3 lysine 9 acetylation (H3K9), recruiting the nuclear receptor binding protein TIF1beta to activate NF90 transcription, thereby increasing HIF-1alpha stability and promoting a malignant phenotype in NPC cells.	Lysine	118-124	Pvt1 oncogene	Homo sapiens	22-26
25082442-0	2014	Significant enhancement of hPrx1 chaperone activity through lysine acetylation.	Lysine	60-66	peroxiredoxin 1	Homo sapiens	27-32
25134515-4	2014	From the experimental data, we developed a predictive mathematical model that explains how chromatin-bound SUV39H1/2 complexes act as nucleation sites and propagate a spatially confined PCH domain with elevated histone H3 lysine 9 trimethylation levels via chromatin dynamics.	Lysine	222-228	suppressor of variegation 3-9 1	Mus musculus	107-116
9294116-3	1997	Because of the presence of plasminogen-like lysine binding sites (LBS) in apo(a), fibrin binding has been proposed to play an important role in Lp(a)"s vascular accumulation.	Lysine	44-50	lipoprotein(a)	Homo sapiens	144-149
25122478-9	2014	Stimulation of cells with EGF resulted in an increase in Akt phosphorylation at Ser473, which was inhibited by c-Src DN, DPI, and LY 294002.	Lysine	130-132	epidermal growth factor	Homo sapiens	26-29
31209362-4	2020	Specifically, SIRT1 interacts with CHK2 and deacetylates it at lysine 520 residue, which suppresses CHK2 phosphorylation, dimerization, and thus activation.	Lysine	63-69	sirtuin 1	Mus musculus	14-19
25122478-12	2014	Treatment of HT-29 cells with EGF induced an increase in kappaB-luciferase activity, which was inhibited by a c-Src DN, LY 294002, and an Akt DN.	Lysine	120-122	epidermal growth factor	Homo sapiens	30-33
9294116-10	1997	These results indicate a correlation between lysine binding properties of Lp(a) and vascular accumulation, supporting the postulated role of apo(a) LBS in this potentially atherogenic characteristic of Lp(a).	Lysine	45-51	lipoprotein(a)	Homo sapiens	74-79
31372881-0	2020	Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma.	Lysine	20-26	homeobox B9	Homo sapiens	11-16
9294116-10	1997	These results indicate a correlation between lysine binding properties of Lp(a) and vascular accumulation, supporting the postulated role of apo(a) LBS in this potentially atherogenic characteristic of Lp(a).	Lysine	45-51	lipoprotein(a)	Homo sapiens	202-207
9238070-10	1997	We also showed that mutation of the lysine residue in the Walker A motif of either the first (K719A) or second (K1384M) nucleotide-binding domain of SUR1 abolished both the potentiatory effects of GTP and GDP on K-ATP currents and their ability to support stimulation by diazoxide.	Lysine	36-42	ATP binding cassette subfamily C member 8	Homo sapiens	149-153
31408253-2	2020	The histone mark histone 3 lysine 4 acetylation (H3K4Ac) is observed in the promoter regions of various EMT marker genes (eg, CDH1 and VIM).	Lysine	27-33	vimentin	Homo sapiens	135-138
24934128-7	2014	Recently, it was found that sheep with two copies of TMEM154 haplotype 1 (encoding lysine at position 35) had lower odds of SRLV infection.	Lysine	83-89	transmembrane protein 154	Ovis aries	53-60
24945908-4	2014	Azides were introduced by applying a recently developed pH-controlled diazotransfer reaction on the primary amines present in ELP (N-terminus and lysine side chains).	Lysine	146-152	nuclear receptor subfamily 5 group A member 1	Homo sapiens	126-129
9247091-0	1997	Late-infantile ceroid-lipofuscinosis: lysine methylation of mitochondrial ATP synthase subunit c from lysosomal storage bodies.	Lysine	38-44	ATP synthase membrane subunit c locus 1	Homo sapiens	60-96
24825348-5	2014	Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP.	Lysine	120-126	sirtuin 2	Mus musculus	102-107
31502334-3	2020	Here we standardized a targeted mass spectrometry method to determine the absolute amount of dystrophin in ng/mg of muscle using full length 13C6-Arg, 13C6,15N2-Lys-labeled dystrophin and parallel reaction monitoring (PRM).	Lysine	161-164	dystrophin	Homo sapiens	93-103
9247091-11	1997	Thus, it appears that specific methylation of lysine residue 43 of mitochondrial ATP synthase subunit c is probably a normal post-translational modification, and that the lysosomal storage of this protein in late-infantile, as well as in juvenile ceroid-lipofuscinosis, does not result from a defect in its methylation.	Lysine	46-52	ATP synthase membrane subunit c locus 1	Homo sapiens	67-103
31949209-2	2020	Lysine acetylation is a key mechanism of post-translational control of various transcription factors, and when acetylated, Foxp3 is stabilized and transcriptionally active.	Lysine	0-6	forkhead box P3	Mus musculus	123-128
24825911-1	2014	Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures.	Lysine	94-100	chromobox 5	Homo sapiens	0-25
24825911-1	2014	Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin, and plays a crucial role in forming higher-order chromatin structures.	Lysine	94-100	chromobox 5	Homo sapiens	27-30
9237811-7	1997	Substitutions Asp --&gt; Asn, Asp --&gt; Lys, Asp --&gt; Leu, show a correlation between diminished affinity for IL-2 receptor and reduced bioactivity measured on TS1beta cells.	Lysine	41-44	interleukin 2 receptor subunit beta	Homo sapiens	113-126
24779776-4	2014	Tri-methylation of lysine 4 on histone H3 (H3K4) enhanced at the promoter of HSP104, PRO1, TPS1 and SOD1 in ethanol-tolerant variants of S. cerevisiae was also diminished after tenth passage in stress-free cultures.	Lysine	19-25	glutamate 5-kinase	Saccharomyces cerevisiae S288C	85-89
32104503-4	2020	Results: Here we report that acetylated AKR1C1 on two lysine residues K185 &amp; K201 is critical to its pro-metastatic role.	Lysine	54-60	aldo-keto reductase family 1 member C1	Homo sapiens	40-46
32104503-7	2020	Conclusion: Acetylation on Lysines 185 and 201 of AKR1C1 dictates its pro-metastatic potential both in vitro and in vivo, and the reverting of acetylation by Sirtuin 2 provides potential therapeutic targets for treatment against metastatic NSCLC patients with high AKR1C1 expression.	Lysine	27-34	aldo-keto reductase family 1 member C1	Homo sapiens	50-56
31792055-0	2020	High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor-related protein 1 requires lysines 80, 88, and 207.	Lysine	112-119	serpin family E member 1	Homo sapiens	25-58
9195925-3	1997	A lysine residue was substituted for glutamic acid in the PH domain of PLC delta1 at position 54 (E54K).	Lysine	2-8	phospholipase C delta 1	Homo sapiens	71-81
33554132-4	2020	BRPF1 is known to recruit the MOZ HAT complex to chromatin by recognizing acetylated lysine residues on the N-terminal histone tail region through its bromodomain.	Lysine	85-91	lysine acetyltransferase 6A	Homo sapiens	30-33
24831002-0	2014	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein.	Lysine	0-3	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	52-59
24831002-0	2014	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein.	Lysine	0-3	synuclein alpha	Homo sapiens	112-127
24831002-3	2014	Recently, Nedd4-1 (neural precursor cell expressed developmentally down-regulated protein 4-1), an E3 ubiquitin ligase, was shown to catalyze the Lys-63-linked polyubiquitination of intracellular aS and thereby facilitate aS degradation by the endolysosomal pathway.	Lysine	146-149	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	10-17
24831002-3	2014	Recently, Nedd4-1 (neural precursor cell expressed developmentally down-regulated protein 4-1), an E3 ubiquitin ligase, was shown to catalyze the Lys-63-linked polyubiquitination of intracellular aS and thereby facilitate aS degradation by the endolysosomal pathway.	Lysine	146-149	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	19-93
24831002-10	2014	Together, these findings demonstrate that Nedd4-1-linked Lys-63 ubiquitination specifies the fate of extrinsic and de novo synthesized aS by facilitating their targeting to endosomes.	Lysine	57-60	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	42-49
9205124-8	1997	The human putative cortistatin peptide has an arginine for lysine substitution, compared to the rat and mouse products, and is N-terminally extended by 3 amino acids.	Lysine	59-65	cortistatin	Homo sapiens	19-30
24960696-0	2014	Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly.	Lysine	11-14	centromere protein A	Gallus gallus	41-47
31222801-0	2020	Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.	Lysine	102-108	mitogen-activated protein kinase kinase kinase 5	Mus musculus	140-176
31222801-5	2020	Here, we further demonstrated that tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes lysine 6 (Lys6)-linked polyubiquitination and subsequent activation of ASK1 to trigger the release of robust proinflammatory and profibrotic factors in hepatocytes, which, in turn, drive HSC activation and hepatic fibrosis.	Lysine	103-109	mitogen-activated protein kinase kinase kinase 5	Mus musculus	174-178
24922651-5	2014	SAHA combined with LY or rapamycin, or both, synergistically reduced p-p70S6K and p-4E-BP1 levels.	Lysine	19-21	ribosomal protein S6 kinase B1	Homo sapiens	71-77
9174192-6	1997	This enzyme differed from TEM-1 (blaT-1B gene) by four amino acid substitutions: Met--&gt;Leu-69, Glu--&gt;Lys-104, Gly--&gt;Ser-238 and Asn--&gt;Asp-276.	Lysine	107-110	hypothetical protein	Escherichia coli	26-31
24488929-5	2014	Further studies reveal that lysine 85 in the carboxyl terminus of Tat is critical for its interaction with Eg5 and hence its effects on Eg5 activity, mitotic progression, and apoptosis.	Lysine	28-34	kinesin family member 11	Homo sapiens	107-110
24488929-5	2014	Further studies reveal that lysine 85 in the carboxyl terminus of Tat is critical for its interaction with Eg5 and hence its effects on Eg5 activity, mitotic progression, and apoptosis.	Lysine	28-34	kinesin family member 11	Homo sapiens	136-139
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	neuronal differentiation 1	Homo sapiens	229-236
32347192-0	2020	Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.	Lysine	26-32	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	74-80
32347192-1	2020	OBJECTIVE: This study aimed to explore whether eukaryotic translation elongation factor 1 alpha 2 affected cell proliferation, migration, and apoptosis via regulating the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 in acute myeloid leukemia.	Lysine	240-246	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	47-97
32347192-6	2020	Additionally, the knockout of eukaryotic translation elongation factor 1 alpha 2 decreased dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression, meanwhile, eukaryotic translation elongation factor 1 alpha 2 wild type overexpression enhanced while eukaryotic translation elongation factor 1 alpha 2 with a K55R substitution overexpression did not influence the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression.	Lysine	160-166	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	30-80
32347192-6	2020	Additionally, the knockout of eukaryotic translation elongation factor 1 alpha 2 decreased dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression, meanwhile, eukaryotic translation elongation factor 1 alpha 2 wild type overexpression enhanced while eukaryotic translation elongation factor 1 alpha 2 with a K55R substitution overexpression did not influence the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression.	Lysine	466-472	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	30-80
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Lysine	189-192	carboxypeptidase B2	Homo sapiens	64-105
32347192-6	2020	Additionally, the knockout of eukaryotic translation elongation factor 1 alpha 2 decreased dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression, meanwhile, eukaryotic translation elongation factor 1 alpha 2 wild type overexpression enhanced while eukaryotic translation elongation factor 1 alpha 2 with a K55R substitution overexpression did not influence the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression.	Lysine	466-472	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	193-243
32347192-6	2020	Additionally, the knockout of eukaryotic translation elongation factor 1 alpha 2 decreased dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression, meanwhile, eukaryotic translation elongation factor 1 alpha 2 wild type overexpression enhanced while eukaryotic translation elongation factor 1 alpha 2 with a K55R substitution overexpression did not influence the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 expression.	Lysine	466-472	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	193-243
9153202-1	1997	Peptides with sequences based on the leader sequence of yeast cytochrome c oxidase subunit IV (pCOX IV-(1-25)) activate the electrophoretic uptake of K+ and other cations such as tetraethylammonium and lysine by rat liver mitochondria with EC50 = 11-15 microM.	Lysine	202-208	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	62-93
31890722-10	2019	In HIV+ ART+ individuals, the metabolites xanthosine and uridine, from nucleotide metabolism, and g-butyrobetaine, from lysine/dietary choline degradation, were also positively or negatively associated with c-IMT and/or cca-IMT (all P < .01), but not its evolution.	Lysine	120-126	CIMT	Homo sapiens	207-212
24858818-1	2014	DOT1L, the only known histone H3-lysine 79 (H3K79) methyltransferase, has been shown to be essential for the survival and proliferation of mixed-linkage leukemia (MLL) gene rearranged leukemia cells, which are often resistant to conventional chemotherapeutic agents.	Lysine	33-39	lysine methyltransferase 2A	Homo sapiens	163-166
24768535-7	2014	However, ISGylation-defective Lys-to-Arg mutations in PCNA or knockdown of any of ISG15, EFP, or USP10 led to persistent recruitment of mono-ubiquitinated PCNA and polymerase-eta to nuclear foci, causing an increase in mutation frequency.	Lysine	30-33	proliferating cell nuclear antigen	Homo sapiens	54-58
24768535-7	2014	However, ISGylation-defective Lys-to-Arg mutations in PCNA or knockdown of any of ISG15, EFP, or USP10 led to persistent recruitment of mono-ubiquitinated PCNA and polymerase-eta to nuclear foci, causing an increase in mutation frequency.	Lysine	30-33	proliferating cell nuclear antigen	Homo sapiens	155-159
9169015-4	1997	Because SNA modifies lysines, we conclude that at least one of the positive charges at the XIP lysine positions (7, 11, or 17) is important for inhibition.	Lysine	21-28	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	91-94
23770847-3	2014	API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-kappaB activation.	Lysine	46-52	baculoviral IAP repeat containing 3	Homo sapiens	0-4
23770847-3	2014	API2-MALT1 promotes ubiquitination of RIP1 at lysine (K) 377, which is necessary for full NF-kappaB activation.	Lysine	46-52	receptor interacting serine/threonine kinase 1	Homo sapiens	38-42
31824148-8	2019	Transferrin receptor 1, TfR1, was detected in lysates prepared from most cancer cell lines studied, contributing to enhanced anticancer potency of the AFt-encapsulated benzothiazoles (5F 203, Phortress, GW 610, GW 608-Lys).	Lysine	218-221	ferritin heavy chain 1	Homo sapiens	151-154
9169015-4	1997	Because SNA modifies lysines, we conclude that at least one of the positive charges at the XIP lysine positions (7, 11, or 17) is important for inhibition.	Lysine	21-27	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	91-94
9169015-5	1997	2CK-XIP (RRLLFYRYVYRCYCAGRQKG) has cysteines at 12 and 14 and only one lysine (at 19).2CK-XIP inhibited Na-Ca exchange; thus positive charges at 12 and 14 are not essential.	Lysine	71-77	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	4-7
24588869-5	2014	Here we present evidence that the histone H3 lysine 9 (H3K9) methyltransferase suppressor of variegation 3-9 homolog 1 (Suv39 h1) transcriptionally represses BZLF1 in B95-8 cells by promoting repressive trimethylation at H3K9 (H3K9me3).	Lysine	45-51	protein Zta	Human gammaherpesvirus 4	158-163
9169015-5	1997	2CK-XIP (RRLLFYRYVYRCYCAGRQKG) has cysteines at 12 and 14 and only one lysine (at 19).2CK-XIP inhibited Na-Ca exchange; thus positive charges at 12 and 14 are not essential.	Lysine	71-77	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	90-93
9153272-3	1997	A plausible mechanism for this inhibitory effect of thrombin involves TAFI (thrombin-activatable fibrinolysis inhibitor, procarboxypeptidase B) which, upon activation, may inhibit fibrinolysis by removing carboxy-terminal lysines from fibrin.	Lysine	222-229	carboxypeptidase B2	Homo sapiens	70-74
24743600-5	2014	We then use mass-spectrometry to identify proteome-wide differential lysine acetylation of putative Sirtuin-3 protein targets in livers of GK and BN rats.	Lysine	69-75	sirtuin 3	Rattus norvegicus	100-109
31423568-10	2019	CONCLUSIONS AND IMPLICATIONS: Inhibition of lysine acetylation suppresses aldosterone-dependent control over the SGK1-ENaC pathway, but does not perturb post-transcriptional signalling, providing a physiological basis for the anti-hypertensive action of KDAC inhibition seen in vivo.	Lysine	44-50	serum/glucocorticoid regulated kinase 1	Mus musculus	113-117
9153272-3	1997	A plausible mechanism for this inhibitory effect of thrombin involves TAFI (thrombin-activatable fibrinolysis inhibitor, procarboxypeptidase B) which, upon activation, may inhibit fibrinolysis by removing carboxy-terminal lysines from fibrin.	Lysine	222-229	carboxypeptidase B2	Homo sapiens	76-119
9175718-5	1997	Inactivation of glutathione reductase by alpha,beta-unsaturated aldehydes was followed by slower NADPH-independent reactions that led to formation of nonfluorescent cross-linked products, accompanied by loss of lysine and histidine residues.	Lysine	211-217	glutathione-disulfide reductase	Homo sapiens	16-37
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	74-80	protein inhibitor of activated STAT 1	Homo sapiens	151-156
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	125-131	protein inhibitor of activated STAT 1	Homo sapiens	151-156
31752909-9	2019	Moreover, PIAS1 itself is modified by SUMO3 overexpression, and mutation of SUMO-acceptor lysine 117 on PIAS1 can impair AR cytoplasmic distribution, demonstrating the essential role of sumoylated PIAS1 in AR translocation.	Lysine	90-96	protein inhibitor of activated STAT 1	Homo sapiens	104-109
31752909-9	2019	Moreover, PIAS1 itself is modified by SUMO3 overexpression, and mutation of SUMO-acceptor lysine 117 on PIAS1 can impair AR cytoplasmic distribution, demonstrating the essential role of sumoylated PIAS1 in AR translocation.	Lysine	90-96	protein inhibitor of activated STAT 1	Homo sapiens	104-109
31752909-10	2019	We further determine that sumoylated PIAS1 interacts with AR lysine 386 and 845 to form a binary complex.	Lysine	61-67	protein inhibitor of activated STAT 1	Homo sapiens	37-42
24261827-10	2014	These results indicate that IMF increased without adverse effects on growth, carcass characteristics and meat quality, when pigs were fed a diet with low lysine/protein ratio.	Lysine	154-160	IMF	Sus scrofa	28-31
24608896-3	2014	Here we show that c- and N-Myc are conjugated to SUMO proteins at conserved lysines in their C-terminal domain.	Lysine	76-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-30
9144392-1	1997	Transglutaminase (TGase) is a calcium-dependent enzyme which catalyzes the iso-peptide cross-link between peptide-bound glutamine and lysine in vivo.	Lysine	134-140	transglutaminase 1	Homo sapiens	0-16
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	63-67
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	69-73
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	glutaryl-Coenzyme A dehydrogenase	Mus musculus	179-183
31644285-0	2019	Chemical Probes Reveal Sirt2"s New Function as a Robust "Eraser" of Lysine Lipoylation.	Lysine	68-74	sirtuin 2	Homo sapiens	23-28
31644285-6	2019	To explore the potential activity of Sirt2 toward lysine lipoylation, we designed a single-step fluorogenic probe, KTlip, which reports delipoylation activity in a continuous manner.	Lysine	50-56	sirtuin 2	Homo sapiens	37-42
31644285-11	2019	Using our chemical probes, we have successfully established the relationship between Sirt2 and lysine lipoylation in living cells for the first time.	Lysine	95-101	sirtuin 2	Homo sapiens	85-90
31659899-5	2019	A molecular dynamics simulation showed that caffeine bound this tyrosinase via Lys379, Lys 376, Asp357, Glu356, Thr308, Gln307, Asp312, and Trp358, thus changing the binding sites of l-tyrosine and the loop conformation adjacent to the active center.	Lysine	79-82	tyrosinase	Mus musculus	64-74
24452550-1	2014	The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16.	Lysine	209-215	lysine acetyltransferase 6A	Homo sapiens	68-71
9144392-1	1997	Transglutaminase (TGase) is a calcium-dependent enzyme which catalyzes the iso-peptide cross-link between peptide-bound glutamine and lysine in vivo.	Lysine	134-140	transglutaminase 1	Homo sapiens	18-23
9241437-4	1997	One of these mutants (RL 4) was characterized by a relative enhancement of soluble lysine.	Lysine	83-89	RAD-like 4	Arabidopsis thaliana	22-26
24239178-3	2014	Studies from our laboratory in Drosophila melanogaster showed that nuclear HCS is associated with heterochromatin bands enriched with the transcriptionally repressive mark histone 3 trimethylated at lysine 9.	Lysine	199-205	Holocarboxylase synthetase	Drosophila melanogaster	75-78
23435416-10	2014	Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that the interaction of JARID2 at these promoters is dependent on EED, a core component of the polycomb repressive complex 2 (PRC2).	Lysine	92-98	myosin light chain 1	Homo sapiens	138-142
31534043-5	2019	Mechanistically, TBK1 phosphorylated multiple picornavirus VP3 proteins at serine residues and ubiquitinated them via K63-linked ubiquitination at lysine residues.	Lysine	147-153	TANK binding kinase 1	Homo sapiens	17-21
9241437-8	1997	A double mutant (RLT40 x RL4) was isolated and characterized by two feedback-desensitized isozymes of aspartate kinase to, respectively, lysine and threonine but no threonine and/or lysine overproduction was observed.	Lysine	137-143	RAD-like 4	Arabidopsis thaliana	25-28
9032262-4	1997	DBP3 encodes a putative RNA helicase, Dbp3p, of 523 amino acids in length, which bears a highly charged amino terminus consisting of 10 tandem lysine-lysine-X repeats ([KKX] repeats).	Lysine	143-149	RNA-dependent ATPase DBP3	Saccharomyces cerevisiae S288C	0-4
31700027-5	2019	We uncovered four lysine residues on Ssa1, K86, K185, K354 and K562 that are deacetylated in response to heat shock.	Lysine	18-24	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	37-41
23873758-7	2014	ChIP reChIP assays revealed that SirT1 and Set7/9 form a protein complex on the COL2A1 promoter region of 3D-cultured chondrocytes, which also demonstrated elevated trimethylated lysine 4 on histone 3 (3MeH3K4), a hallmark of Set7/9 methyltransferase activity.	Lysine	179-185	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	43-49
23318417-7	2014	AR activation recruits the polycomb group protein EZH2, which subsequently catalyzes histone H3 lysine 27 tri-methylation around the NOV promoter, thus leading to repressive chromatin remodeling and epigenetic silencing.	Lysine	96-102	cellular communication network factor 3	Homo sapiens	133-136
23318425-4	2014	DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.	Lysine	138-144	ATM serine/threonine kinase	Homo sapiens	200-203
9032262-4	1997	DBP3 encodes a putative RNA helicase, Dbp3p, of 523 amino acids in length, which bears a highly charged amino terminus consisting of 10 tandem lysine-lysine-X repeats ([KKX] repeats).	Lysine	143-149	RNA-dependent ATPase DBP3	Saccharomyces cerevisiae S288C	38-43
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	melanocyte inducing transcription factor	Homo sapiens	28-32
9032262-4	1997	DBP3 encodes a putative RNA helicase, Dbp3p, of 523 amino acids in length, which bears a highly charged amino terminus consisting of 10 tandem lysine-lysine-X repeats ([KKX] repeats).	Lysine	150-156	RNA-dependent ATPase DBP3	Saccharomyces cerevisiae S288C	0-4
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	melanocyte inducing transcription factor	Homo sapiens	74-78
31693890-0	2019	Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.	Lysine	37-43	SET and MYND domain containing 2	Homo sapiens	22-27
24257758-6	2014	Furthermore, sumoylation of MITF at Lys-316, known to negatively regulate MITF transcriptional activity, inhibited MITF interactions with FUS and BRG1 in a p38 MAPK phosphorylation-dependent manner.	Lysine	36-39	melanocyte inducing transcription factor	Homo sapiens	74-78
31693890-3	2019	Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1).	Lysine	88-94	SET and MYND domain containing 2	Homo sapiens	19-51
9032262-4	1997	DBP3 encodes a putative RNA helicase, Dbp3p, of 523 amino acids in length, which bears a highly charged amino terminus consisting of 10 tandem lysine-lysine-X repeats ([KKX] repeats).	Lysine	150-156	RNA-dependent ATPase DBP3	Saccharomyces cerevisiae S288C	38-43
31693890-3	2019	Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1).	Lysine	88-94	SET and MYND domain containing 2	Homo sapiens	53-58
9025964-8	1997	In addition, it was observed that the C-terminal lysine residue (K438) was absent from the deglycosylated Fc fragment, presumably due to carboxypeptidase B activity that occurs during the in vivo production of the B72.3 MAb in murine hosts.	Lysine	49-55	carboxypeptidase B1 (tissue)	Mus musculus	137-155
30787391-7	2019	Mechanistically, Sirt6 deacetylated ERalpha protein to prevent its proteasomal degradation, in which lysine 171 and lysine 299 were critical residues.	Lysine	101-107	estrogen receptor 1 (alpha)	Mus musculus	36-43
30787391-7	2019	Mechanistically, Sirt6 deacetylated ERalpha protein to prevent its proteasomal degradation, in which lysine 171 and lysine 299 were critical residues.	Lysine	116-122	estrogen receptor 1 (alpha)	Mus musculus	36-43
24268540-14	2014	Compounds that are specific for DapL could be potential biocides (antibiotic, herbicide or algaecide) that are nontoxic to animals since animals do not contain the enzymes necessary for PG or Lys synthesis.	Lysine	192-195	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	32-36
8939951-3	1996	Replacement of several conserved Lys residues in the C-terminal region of mouse and rat sPLA2s by Glu resulted in a marked reduction of their capacities to bind to heparin and mammalian cell surfaces without affecting their enzymatic activities toward dispersed phospholipid as a substrate.	Lysine	33-36	phospholipase A2 group IIA	Rattus norvegicus	88-93
24675890-5	2014	This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression.	Lysine	152-158	phosphatase and tensin homolog	Homo sapiens	92-96
24752040-2	2014	Suv39h1 is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9, which is associated with the suppression of inflammatory genes in diabetes.	Lysine	83-89	SUV39H1 histone lysine methyltransferase	Rattus norvegicus	0-7
31450981-5	2019	Given the reduced cell number in Sin3a-depleted embryos, blocked cell proliferation is observed, likely because of the increased level of Trp53 acetylation at lysine 379.	Lysine	159-165	transformation related protein 53	Mus musculus	138-143
8955878-0	1996	Catalytic roles of lysines (K9, K27, K31) in the N-terminal domain in human adenylate kinase by random site-directed mutagenesis.	Lysine	19-26	keratin 27	Homo sapiens	32-35
30891914-2	2019	A single nucleotide, T &gt; C, change in exon 13, leading to a Thr1289 Ala substitution, was identified in the lysine (K)-specific methyltransferase 2D gene (Kmt2d) located on chromosome 15.	Lysine	111-117	lysine (K)-specific methyltransferase 2D	Mus musculus	158-163
24471655-0	2014	A new delta chain variant, Hb A2-Tunis [delta46(CD5)Gly   Glu; HBD: c.140G&gt;A], observed in a Tunisian family in association with a compound heterozygosity for Hb C [beta6(A3)Glu   Lys; HBB: c.19G&gt;A] beta(0)-thalassemia [IVS-I-1 (beta143, G&gt;A); HBB: c.92+1G&gt;A].	Lysine	183-186	CD5 molecule	Homo sapiens	48-51
8955878-0	1996	Catalytic roles of lysines (K9, K27, K31) in the N-terminal domain in human adenylate kinase by random site-directed mutagenesis.	Lysine	19-26	keratin 31	Homo sapiens	37-40
8943576-6	1996	Substitution analysis of the amino acid residues involved in binding to DR1 and DRB5*0101 identified F-354 as the common primary contact residue (P1), while allele-specific differences were found in positions P4, P6 and in the C-terminal anchor residue (valine at P9 for DR1 or lysine at P10 for DRB5*0101).	Lysine	278-284	down-regulator of transcription 1	Homo sapiens	72-75
24214534-7	2014	The gamma-zein deletion further increased lysine in QPM in its homozygous and hemizygous states.	Lysine	42-48	prolamin 50 kDa gamma zein	Zea mays	4-14
24129573-0	2013	Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.	Lysine	83-89	KMT5A pseudogene 1	Homo sapiens	69-73
31265113-5	2019	Dietary Lys level had a linear (P &lt; 0.05) and quadratic (P &lt; 0.05) effects on maternal hepatic expression of mechanistic target of rapamycin, eukaryotic translation initiation factor 4E binding protein 1, ubiquitin conjugating enzyme E2K (UBE2K), cathepsin B (CTSB), and quadratically (P &lt; 0.05) increased the concentrations of plasma Lys, leucine, threonine, and tryptophan in duck breeders.	Lysine	8-11	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	148-209
31265113-5	2019	Dietary Lys level had a linear (P &lt; 0.05) and quadratic (P &lt; 0.05) effects on maternal hepatic expression of mechanistic target of rapamycin, eukaryotic translation initiation factor 4E binding protein 1, ubiquitin conjugating enzyme E2K (UBE2K), cathepsin B (CTSB), and quadratically (P &lt; 0.05) increased the concentrations of plasma Lys, leucine, threonine, and tryptophan in duck breeders.	Lysine	8-11	ubiquitin conjugating enzyme E2 K	Homo sapiens	211-243
31265113-5	2019	Dietary Lys level had a linear (P &lt; 0.05) and quadratic (P &lt; 0.05) effects on maternal hepatic expression of mechanistic target of rapamycin, eukaryotic translation initiation factor 4E binding protein 1, ubiquitin conjugating enzyme E2K (UBE2K), cathepsin B (CTSB), and quadratically (P &lt; 0.05) increased the concentrations of plasma Lys, leucine, threonine, and tryptophan in duck breeders.	Lysine	8-11	ubiquitin conjugating enzyme E2 K	Homo sapiens	245-250
31265113-6	2019	In contrast, maternal dietary Lys suppressed expression of proteasome 26S subunit, UBE2K, and CTSB in the liver of hatchlings.	Lysine	30-33	ubiquitin conjugating enzyme E2 K	Homo sapiens	83-88
31265113-8	2019	Maternal dietary Lys suppressed hepatic expression of VLDLR in the hatchlings.	Lysine	17-20	very low density lipoprotein receptor	Homo sapiens	54-59
24129573-2	2013	Interferon-induced transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1) to reduce its antiviral activity, mediated by the lysine methyltransferase SET7.	Lysine	84-90	KMT5A pseudogene 1	Homo sapiens	193-197
8921867-8	1996	Rare recombination events between two overlapping YACs could be identified in yeast clones able to grow in lysine- and adenine-deficient medium in the presence of 5-fluoro-orotic acid which is toxic for yeast cells containing a YAC with a functional URA3 gene.	Lysine	107-113	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	250-254
23899557-4	2013	Antibodies for p53 serine phosphorylation or lysine acetylation indicated a different post-translational status of recombinant p53 in the nucleus and mitochondrion, respectively.	Lysine	45-51	transformation related protein 53, pseudogene	Mus musculus	127-130
31665643-2	2019	Both tolerance pathways critically rely on ubiquitylation of the proliferating-cell nuclear antigen (PCNA) on lysine 164 and have been proposed to operate uncoupled from replication.	Lysine	110-116	proliferating cell nuclear antigen	Homo sapiens	65-99
31665643-2	2019	Both tolerance pathways critically rely on ubiquitylation of the proliferating-cell nuclear antigen (PCNA) on lysine 164 and have been proposed to operate uncoupled from replication.	Lysine	110-116	proliferating cell nuclear antigen	Homo sapiens	101-105
8841118-6	1996	Intermolecular contacts between the DNA and the 8-kDa domain of a symmetry-related pol beta molecule reveal a plausible binding site on the 8-kDa domain for the downstream oligonucleotide of a gapped-DNA substrate; in addition to a lysine-rich binding pocket that accommodates a 5"-PO4 end group, the 8-kDa domain also contains a newly discovered helix-hairpin-helix (HhH) motif that binds to DNA in the same way as does a structurally and sequentially homologous HhH motif in the 31-kDa domain.	Lysine	232-238	DNA polymerase beta	Homo sapiens	83-91
31479228-2	2019	The p15PAF gene is overexpressed in several types of human cancer, and its function is regulated by monoubiquitination of two lysines (K15 and K24) at the protein N-terminal region.	Lysine	126-133	PCNA clamp associated factor	Homo sapiens	4-10
24005904-6	2013	The aP2 locus exhibited elevated chromatin accessibility (&gt;2.1-fold), methylation of histone H3 lysine 4 (&gt;4.5-fold), and acetylation of histone H4 (&gt;2.5-fold) in USP2-KD cells.	Lysine	99-105	fatty acid binding protein 4	Homo sapiens	4-7
21153111-8	1996	Lys-48, known to function in formation of ubiquitin polymers, was present in hUCRP, but mutated to Arg in bUCRP.	Lysine	0-3	ubiquitin	Bos taurus	42-51
24193022-2	2013	Novel DPP-IV inhibitors were identified comprising of three potent dipeptides (Trp-Arg, Trp-Lys and Trp-Leu) with half maximum inhibitory concentration (IC50 values) &lt;45 muM.	Lysine	92-95	dipeptidyl peptidase 4	Homo sapiens	6-12
33455222-3	2019	We successfully synthesized the polypeptide (poly-l-lysine [PLL]) derivative of metformin (LysMET) and demonstrated its capacity as an anticancer therapeutic and gene carrier.	Lysine	45-58	SAFB like transcription modulator	Homo sapiens	80-89
21153111-8	1996	Lys-48, known to function in formation of ubiquitin polymers, was present in hUCRP, but mutated to Arg in bUCRP.	Lysine	0-3	ISG15 ubiquitin like modifier	Homo sapiens	77-82
31615119-4	2019	Our analyses revealed particular lysine sites at histone sequences targeted by the HDA6 enzyme, and by TSA- and NaB-sensitive HDAs.	Lysine	33-39	histone deacetylase 6	Arabidopsis thaliana	83-87
24129578-7	2013	Taken together, these findings demonstrated that three buried glutamic acid-lysine pairs, in concert with hydrophobic interactions of core residues, provide the major specificity and stability requirements for Hec1-Nuf2 dimerization and NDC80 complex formation.	Lysine	76-82	NUF2 component of NDC80 kinetochore complex	Homo sapiens	215-219
31366618-2	2019	Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.	Lysine	64-70	sirtuin 2	Homo sapiens	136-145
31366618-2	2019	Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.	Lysine	64-70	sirtuin 2	Homo sapiens	147-152
8879195-6	1996	Analysis of the cDNA and genomic DNA of this patient showed that the patient is a compound heterozygote for a triplet nucleotide deletion in the p67-phox gene, predicting an in-frame deletion of lysine 58 in the p67-phox protein and a larger deletion of 11-13 kb in the other allele.	Lysine	195-201	neutrophil cytosolic factor 2	Homo sapiens	145-153
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Lysine	196-202	HDGF like 3	Homo sapiens	78-110
24396869-1	2013	SUV420H1 and SUV420H2 are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation.	Lysine	71-77	lysine methyltransferase 5B	Homo sapiens	0-8
24396869-1	2013	SUV420H1 and SUV420H2 are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation.	Lysine	71-77	lysine methyltransferase 5C	Homo sapiens	13-21
24100029-6	2013	We showed that the pathogenic mutation preferentially impairs the interaction with Lys-63 and Met-1-linked di-Ub, which correlates with its ubiquitin binding defect in vivo.	Lysine	83-86	granzyme M	Homo sapiens	94-99
24100029-8	2013	Extensive mutagenesis was then performed on NEMO ZF and characterization of mutants allowed the proposal of a structural model of NEMO ZF in interaction with a Lys-63 di-Ub chain.	Lysine	160-163	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	44-48
31616795-4	2019	We identified two proteins, lens epithelium-derived growth factor (LEDGF) and hepatoma-derived growth factor 2 (HDGF2), each containing two high mobility group A (HMGA)-like AT-hooks and a methyl-lysine reading Pro-Trp-Trp-Pro (PWWP) domain that binds to H3K36me2 and H3K36me3.LEDGF and HDGF2 colocalize with H3K36me2/3 at genomic regions containing active genes.	Lysine	196-202	HDGF like 3	Homo sapiens	112-117
24100029-8	2013	Extensive mutagenesis was then performed on NEMO ZF and characterization of mutants allowed the proposal of a structural model of NEMO ZF in interaction with a Lys-63 di-Ub chain.	Lysine	160-163	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	130-134
31062674-9	2019	In biceps femoris muscle of lysine-deficient pigs, the activity of FAS and ME enzymes increased, ME1 gene was upregulated (added to FASN gene in the case of Iberian pigs; P < 0.01 to P < 0.001) and PPARA gene was downregulated (P < 0.05).	Lysine	28-34	peroxisome proliferator activated receptor alpha	Sus scrofa	198-203
8808931-5	1996	These analyses indicated that the internal residues Lys-564 and Lys-690 of HlyA, which have recently been shown by others to be fatty acid acylated by HlyC in vitro, are also the only modification sites in vivo.	Lysine	52-55	hemolysin transport protein	Escherichia coli	75-79
31449053-5	2019	Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degradation.	Lysine	85-92	heat shock protein 90 alpha family class B member 1	Homo sapiens	32-38
31215640-4	2019	Here, we demonstrated that CD147 undergoes an intramembranous cleavage by the gamma-secretase at lysine 231 to release its intracellular domains (ICDs).	Lysine	97-103	basigin (Ok blood group)	Homo sapiens	27-32
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	105-109
24136356-2	2013	Here, we describe activated PI3K-delta syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110delta protein, the catalytic subunit of phosphoinositide 3-kinase delta (PI3Kdelta), encoded by the PIK3CD gene.	Lysine	124-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	186-195
24136356-2	2013	Here, we describe activated PI3K-delta syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110delta protein, the catalytic subunit of phosphoinositide 3-kinase delta (PI3Kdelta), encoded by the PIK3CD gene.	Lysine	124-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	263-272
24136356-2	2013	Here, we describe activated PI3K-delta syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110delta protein, the catalytic subunit of phosphoinositide 3-kinase delta (PI3Kdelta), encoded by the PIK3CD gene.	Lysine	124-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	290-296
8808931-5	1996	These analyses indicated that the internal residues Lys-564 and Lys-690 of HlyA, which have recently been shown by others to be fatty acid acylated by HlyC in vitro, are also the only modification sites in vivo.	Lysine	64-67	hemolysin transport protein	Escherichia coli	75-79
31509528-6	2019	Whereas the properties of xlODC1 and xlAZIN1 were similar to those reported for their mammalian orthologues, the former catalyzing the decarboxylation of L-ornithine preferentially to that of L-lysine, xlAZIN2/xlODC2 showed important differences with respect to human and mouse AZIN2.	Lysine	192-200	ornithine decarboxylase 1 L homeolog	Xenopus laevis	26-32
8808931-7	1996	Single modifications in mutant and truncated HlyA derivatives suggested that both lysine residues are independently fatty acid acylated by a mechanism requiring additional sequences or structures flanking the corresponding acylation site.	Lysine	82-88	hemolysin transport protein	Escherichia coli	45-49
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Lysine	136-142	deoxyhypusine hydroxylase	Homo sapiens	0-4
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Lysine	136-142	eukaryotic translation initiation factor 5A	Homo sapiens	146-177
8760502-2	1996	The elastic portion of titin comprises two distinct structural motifs, immunoglobulin (Ig) domains and the PEVK titin, which is a novel motif family rich in proline, glutamate, valine and lysine residues.	Lysine	188-194	titin	Homo sapiens	23-28
23943044-8	2013	DOHH, a metalloprotein which consists of ferrous iron and catalyzes the second step of the posttranslational modification at a specific lysine in eukaryotic initiation factor 5A (EIF-5A) to hypusine.	Lysine	136-142	eukaryotic translation initiation factor 5A	Homo sapiens	179-185
23968852-4	2013	In this study, dendrigraft poly-l-lysine (DGL) was decorated by dermorphin (a mu-opiate receptor agonist) through PEG for efficient brain-targeting, then complexed with anti-Ask1 shRNA plasmid DNA, yielding the DGL-PEG-dermorphin/shRNA NPs.	Lysine	27-40	opioid receptor mu 1	Homo sapiens	78-96
23968852-4	2013	In this study, dendrigraft poly-l-lysine (DGL) was decorated by dermorphin (a mu-opiate receptor agonist) through PEG for efficient brain-targeting, then complexed with anti-Ask1 shRNA plasmid DNA, yielding the DGL-PEG-dermorphin/shRNA NPs.	Lysine	27-40	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	174-178
31324717-0	2019	Substrate docking-mediated specific and efficient lysine methylation by the SET domain-containing histone methyltransferase SETD7.	Lysine	50-56	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	124-129
31324717-4	2019	Here, using several biochemical approaches, including analytical gel filtration chromatography, isothermal titration calorimetry, and in vitro methylation assays, we discovered that SET domain-containing 7 histone lysine methyltransferase (SETD7), a KMT capable of methylating both histone and nonhistone proteins, uses its N-terminal membrane occupation and recognition nexus (MORN) repeats to dock its substrates and subsequently juxtapose their Lys methylation motif for efficient and specific methylation by the catalytic SET domain.	Lysine	448-451	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	240-245
31326165-11	2019	Our results indicate that casein synthesis was regulated by Lys/Met ratio via JAK2/ELF5, mTOR, and its downstream RPS6KB1 and EIF4EBP1 signaling.	Lysine	60-63	Janus kinase 2	Bos taurus	78-82
31326165-11	2019	Our results indicate that casein synthesis was regulated by Lys/Met ratio via JAK2/ELF5, mTOR, and its downstream RPS6KB1 and EIF4EBP1 signaling.	Lysine	60-63	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	126-134
31326165-13	2019	Within the range of substrate levels in the present study, a change in Lys/Met ratio had a stronger effect on abundance of alphaS1-casein and beta-casein than a change in glucose level.	Lysine	71-74	casein alpha s1	Bos taurus	123-137
23955539-7	2013	Resistin-induced WHSC1 increases the dimethylation of histone 3 at lysine 36 and decreases the trimethylation of histone 3 at lysine 27 on the promoter of Twist, resulting in an enhancement of the expression of Twist.	Lysine	67-73	resistin	Homo sapiens	0-8
23955539-7	2013	Resistin-induced WHSC1 increases the dimethylation of histone 3 at lysine 36 and decreases the trimethylation of histone 3 at lysine 27 on the promoter of Twist, resulting in an enhancement of the expression of Twist.	Lysine	126-132	resistin	Homo sapiens	0-8
8760502-2	1996	The elastic portion of titin comprises two distinct structural motifs, immunoglobulin (Ig) domains and the PEVK titin, which is a novel motif family rich in proline, glutamate, valine and lysine residues.	Lysine	188-194	titin	Homo sapiens	112-117
31480279-5	2019	These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1.	Lysine	76-82	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	198-201
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Lysine	367-373	peroxisomal biogenesis factor 5	Homo sapiens	131-144
24186071-3	2013	Importantly, both CFP1 and KDM2A are associated with enzymatic activities that modulate specific histone lysine methylation marks.	Lysine	105-111	CXXC finger protein 1	Homo sapiens	18-22
8804587-1	1996	We reacted a fluorescent probe, N-methyl-2-anilino-6-naphthalenesulfonyl chloride (MNS-Ci), with a specific lysine residue of porcine cardiac myosin located in the S-2 region of myosin.	Lysine	108-114	myosin, heavy chain 15	Gallus gallus	142-148
24030825-2	2013	NEMO ubiquitination requires a dual target specificity of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiquitin.	Lysine	78-84	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	0-4
24030825-2	2013	NEMO ubiquitination requires a dual target specificity of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiquitin.	Lysine	78-84	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	88-92
31303386-3	2019	Among these compounds, 14c showed the highest activity (IC50 = 0.008 muM) against ALK5 kinase, which was 16.1-fold and 1.8-fold higher than those of positive control compounds LY-2157299 (IC50 = 0.129 muM) and EW-7197 (IC50 = 0.014 muM), respectively.	Lysine	176-178	transforming growth factor beta receptor 1	Homo sapiens	82-86
24030825-5	2013	Whereas the RBR-LDD region on HOIP is sufficient for targeting the ubiquitin N terminus, the priming lysine modification on NEMO requires catalysis by the RBR domain of HOIL-1L as well as the catalytic machinery of the RBR-LDD domains of HOIP.	Lysine	101-107	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	124-128
8804587-1	1996	We reacted a fluorescent probe, N-methyl-2-anilino-6-naphthalenesulfonyl chloride (MNS-Ci), with a specific lysine residue of porcine cardiac myosin located in the S-2 region of myosin.	Lysine	108-114	myosin, heavy chain 15	Gallus gallus	178-184
31416910-4	2019	A critical target of OGT is the polycomb repressive complex 2 (PRC2) containing the histone lysine methyltransferase EZH2 that mediates trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	92-98	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	21-24
8804587-4	1996	The atomic coordinates of these LC2 loci can be closely approximated, and the FRET measurements were used to determine the position of the MNS-labeled lysine with respect to the myosin head.	Lysine	151-157	myosin, heavy chain 15	Gallus gallus	178-184
8654567-1	1996	The interaction of human plasmin with human alpha2-antiplasmin was measured in the presence and absence of lysine-binding ligands using the corresponding active site fluorescence changes.	Lysine	107-113	plasminogen	Homo sapiens	25-32
31409767-4	2019	Mechanically, SIRT3 interacted with pyruvate dehydrogenase E1alpha (PDHA1) and deacetylated Lys-83 both in vitro and in vivo under HS.	Lysine	92-95	sirtuin 3	Mus musculus	14-19
24339737-0	2013	The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.	Lysine	65-71	H2B clustered histone 21	Homo sapiens	87-90
24339737-3	2013	In the present study, we demonstrated that EZH2 has the function to monomethylate lysine 120 on histone H2B (H2BK120).	Lysine	82-88	H2B clustered histone 21	Homo sapiens	104-107
24339737-3	2013	In the present study, we demonstrated that EZH2 has the function to monomethylate lysine 120 on histone H2B (H2BK120).	Lysine	82-88	H2B clustered histone 21	Homo sapiens	109-116
8654567-4	1996	Substantial reductions in k1 were seen in the presence of trans-4-(aminomethyl)cyclohexane-1-carboxylic acid at concentrations corresponding to lysine-binding site interactions at kringle 4 of plasmin; at saturation the rate constant is reduced 20-fold, whereas the effect of saturation of kringle 1 is only a 2-fold reduction.	Lysine	144-150	plasminogen	Homo sapiens	193-200
31388051-5	2019	UBE2v1 mediates the formation of lysine 63-linked ubiquitin chains, a mechanism we previously showed as involved in DN kidney fibrosis.	Lysine	33-39	ubiquitin conjugating enzyme E2 V1	Homo sapiens	0-6
8654567-5	1996	It is thus found that the interaction of alpha2-antiplasmin with the lysine-binding site of kringle 1 is of little importance compared with that of kringle 4 in regulating the inhibition reaction of plasmin with alpha2-antiplasmin.	Lysine	69-75	plasminogen	Homo sapiens	52-59
24101509-5	2013	Here we show that SET and MYND domain containing 2 (SMYD2), a histone H3K4 and H3K36 methyltransferase, directly methylates ERalpha protein at lysine 266 (K266) both in vitro and in cells.	Lysine	143-149	SET and MYND domain containing 2	Homo sapiens	18-50
8963723-0	1996	A quantitative immunoassay for the lysine-binding function of lipoprotein(a).	Lysine	35-41	lipoprotein(a)	Homo sapiens	62-76
24101509-5	2013	Here we show that SET and MYND domain containing 2 (SMYD2), a histone H3K4 and H3K36 methyltransferase, directly methylates ERalpha protein at lysine 266 (K266) both in vitro and in cells.	Lysine	143-149	SET and MYND domain containing 2	Homo sapiens	52-57
24103193-9	2013	DHPS catalyzes the first step in hypusine formation, a unique amino acid formed by the posttranslational modification of the protein eukaryotic translation initiation factor 5A in a specific lysine residue.	Lysine	191-197	eukaryotic translation initiation factor 5A-1	Sus scrofa	133-176
8963723-2	1996	Apo(a), the unique apoprotein of lipoprotein(a) (Lp[a]), can express lysine-binding sites(s) (LBS).	Lysine	69-75	lipoprotein(a)	Homo sapiens	0-6
31138472-1	2019	A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads: MK-0893 and LY-2409021.	Lysine	170-172	glucagon receptor	Rattus norvegicus	65-82
8963723-2	1996	Apo(a), the unique apoprotein of lipoprotein(a) (Lp[a]), can express lysine-binding sites(s) (LBS).	Lysine	69-75	lipoprotein(a)	Homo sapiens	33-47
31138472-1	2019	A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads: MK-0893 and LY-2409021.	Lysine	170-172	glucagon receptor	Rattus norvegicus	84-88
24116170-7	2013	Both IGF1 and GSK3i induced chromatin-level changes favoring transcriptional activation at the Kitl promoter including increased histone H3/H4 acetylation and H3 lysine (K) 4 methylation, reduced H3K9 and H3K27 methylation and reduced occupancy by the H3K27 methyltransferase EZH2.	Lysine	162-168	kit ligand	Mus musculus	95-99
24116191-4	2013	The structure revealed that a cluster of lysine and arginine residues forms the positively charged DNA binding surface of human cGAS, which is important for the STING-dependent immune activation.	Lysine	41-47	cyclic GMP-AMP synthase	Homo sapiens	128-132
8963723-8	1996	When applied to plasma samples, the LBS activity of Lp(a) ranged from 0% to 100% of an isolated reference Lp(a); the signal corresponded to the percent retention of Lp(a) on a lysine-Sepharose but did not correlate well with total Lp(a) levels in plasma.	Lysine	176-182	lipoprotein(a)	Homo sapiens	52-57
8605329-6	1996	Finally, our biochemical studies show that the JAK3 kinase domain, but not the pseudo-kinase domain, has tyrosine kinase activity and, furthermore, that JAK3 kinase activity is abolished by an amino acid substitution of the conserved lysine in the kinase domain (K851R).	Lysine	234-240	Janus kinase 3	Mus musculus	47-51
24001608-6	2013	Analyses of oastlABC pollen demonstrated that the presence of at least one functional OAS-TL isoform is essential for the proper function of the male gametophyte, although the synthesis of histidine, lysine, and tryptophan is dispensable in pollen.	Lysine	200-206	O-acetylserine (thiol) lyase (OAS-TL) 	Arabidopsis thaliana	86-92
32721126-8	2019	A dramatic increase in encapsulation efficiency was achieved, with more than 380 molecules of GW 608-Lys molecules per AFt cage.	Lysine	101-104	ferritin heavy chain 1	Homo sapiens	119-122
32721126-12	2019	Of particular interest is the encapsulation efficiency and in vitro antitumour activity of AFt-GW 608-Lys, which warrants further preclinical evaluation.	Lysine	102-105	ferritin heavy chain 1	Homo sapiens	91-94
8605329-6	1996	Finally, our biochemical studies show that the JAK3 kinase domain, but not the pseudo-kinase domain, has tyrosine kinase activity and, furthermore, that JAK3 kinase activity is abolished by an amino acid substitution of the conserved lysine in the kinase domain (K851R).	Lysine	234-240	Janus kinase 3	Mus musculus	153-157
31370883-1	2019	SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-DEAF1) domain-containing protein 2 (SMYD2) is a protein methyltransferase that methylates histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) and diverse nonhistone proteins.	Lysine	190-196	SET and MYND domain containing 2	Homo sapiens	122-127
24204298-11	2013	Repression of TER94 is attributable to spreading of the eve Pc domain into the TER94 locus, accompanied by an increase in histone H3 trimethylation at lysine 27.	Lysine	151-157	even skipped	Drosophila melanogaster	56-59
8605211-2	1996	Toward this end, we have labeled the GTP-binding protein Cdc42Hs with the environmentally sensitive fluorophore succinimidyl 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]hexanoate (sNBD) at a single reactive lysine residue.	Lysine	207-213	cell division cycle 42	Homo sapiens	57-64
31370883-1	2019	SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-DEAF1) domain-containing protein 2 (SMYD2) is a protein methyltransferase that methylates histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) and diverse nonhistone proteins.	Lysine	209-215	SET and MYND domain containing 2	Homo sapiens	122-127
31096156-1	2019	Lysine-specific demethylase 1 (LSD1), demethylase against mono- and di - methylated histone3 lysine 4, has emerged as a promising target in oncology.	Lysine	93-99	methyl-CpG binding domain protein 2	Homo sapiens	16-27
24025767-5	2013	Usp16 can remove ubiquitin from histone H2A on lysine 119, a critical mark for the maintenance of multiple somatic tissues.	Lysine	47-53	ubiquitin specific peptidase 16	Homo sapiens	0-5
8983345-8	1996	The primary urinary catabolite of [Nle4,D-Phe7, Lys11-(125I)IBA]-alpha-MSH was the lysine conjugate of iodobenzoic acid, whereas radioiodide was the chief catabolite generated from [Tyr2(131I),Nle4,D-Phe7]-alpha-MSH.	Lysine	83-89	pro-opiomelanocortin-alpha	Mus musculus	65-74
23980167-7	2013	When the lysine residues adjacent to the SH2 domain of STAT5 were mutated, STAT5 acetylation decreased concomitant with a decrease in its transcriptional activity.	Lysine	9-15	signal transducer and activator of transcription 5A	Homo sapiens	55-60
31367038-6	2019	We reveal a connection between polyamine and lysine metabolism during stress situations, in the form of a promiscuous enzymatic reaction in which the first enzyme of the polyamine pathway, Spe1p, decarboxylates lysine and forms an alternative polyamine, cadaverine.	Lysine	45-51	ornithine decarboxylase SPE1	Saccharomyces cerevisiae S288C	189-194
8605626-4	1996	The functional epitope that primarily determines binding affinity consists of residues Gln 66, Lys 84 and Arg 89 in Raf.	Lysine	95-98	zinc fingers and homeoboxes 2	Homo sapiens	116-119
31367038-6	2019	We reveal a connection between polyamine and lysine metabolism during stress situations, in the form of a promiscuous enzymatic reaction in which the first enzyme of the polyamine pathway, Spe1p, decarboxylates lysine and forms an alternative polyamine, cadaverine.	Lysine	211-217	ornithine decarboxylase SPE1	Saccharomyces cerevisiae S288C	189-194
23980167-7	2013	When the lysine residues adjacent to the SH2 domain of STAT5 were mutated, STAT5 acetylation decreased concomitant with a decrease in its transcriptional activity.	Lysine	9-15	signal transducer and activator of transcription 5A	Homo sapiens	75-80
25702411-1	2013	Linear hepta-peptide Cys-Lys-Gly-Asp-Trp-Asp-Cys was synthesized first and then disulfide bond was formed between the Cys1 and Cys7 to develop cyclo-heptapeptide containing Lys-Gly-Asp-sequence.	Lysine	25-28	cystin 1	Homo sapiens	118-122
31147442-2	2019	JMJD6 is reported to catalyze hydroxylation of lysine residue(s) of histones, the tumor-suppressor protein p53, and splicing regulatory proteins, including u2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit (U2AF65).	Lysine	47-53	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
12226216-1	1996	The first enzyme of the lysine degradation pathway in maize (Zea mays L.), lysine-ketoglutarate reductase, condenses lysine and [alpha]-ketoglutarate into saccharopine using NADPH as a cofactor, whereas the second, saccharopine dehydrogenase, converts saccharopine to [alpha]-aminoadipic-[delta]-semialdehyde and glutamic acid using NAD+ or NADP+ as a cofactor.	Lysine	24-30	Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410	Zea mays	215-241
31147442-2	2019	JMJD6 is reported to catalyze hydroxylation of lysine residue(s) of histones, the tumor-suppressor protein p53, and splicing regulatory proteins, including u2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit (U2AF65).	Lysine	47-53	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	224-230
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-12	2013	However, gender stratification indicated the possible effect of heterozygous constitution of hOGG1 gene (Ser/Cys) on lung cancer risk in female non-smokers (OR = 0.20; p = 0.01) and heterozygous constitution of XPC gene (Lys/Gln) in male smokers (OR = 2.70; p = 0.01).	Lysine	221-224	8-oxoguanine DNA glycosylase	Homo sapiens	93-98
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	114-120	TNF receptor associated factor 6	Homo sapiens	99-104
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	157-163	TNF receptor associated factor 6	Homo sapiens	99-104
31160341-4	2019	The structure revealed that the direction of lysine entry is similar to that described for human proliferating cell nuclear antigen (PCNA), a small ubiquitin-like modifier (SUMO)-targeted substrate, and thus differs from the canonical SUMO-targeted substrate entry.	Lysine	45-51	proliferating cell nuclear antigen	Homo sapiens	97-131
31160341-4	2019	The structure revealed that the direction of lysine entry is similar to that described for human proliferating cell nuclear antigen (PCNA), a small ubiquitin-like modifier (SUMO)-targeted substrate, and thus differs from the canonical SUMO-targeted substrate entry.	Lysine	45-51	proliferating cell nuclear antigen	Homo sapiens	133-137
12226216-1	1996	The first enzyme of the lysine degradation pathway in maize (Zea mays L.), lysine-ketoglutarate reductase, condenses lysine and [alpha]-ketoglutarate into saccharopine using NADPH as a cofactor, whereas the second, saccharopine dehydrogenase, converts saccharopine to [alpha]-aminoadipic-[delta]-semialdehyde and glutamic acid using NAD+ or NADP+ as a cofactor.	Lysine	75-81	Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410	Zea mays	215-241
8919551-0	1996	The DAP pathway to lysine as a target for antimicrobial agents.	Lysine	19-25	death associated protein	Homo sapiens	4-7
31246453-2	2019	Neolymphostin A was recently shown to strongly inhibit phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) in a covalent manner via conjugation to a catalytic lysine residue in the ATP-binding pocket of the enzymes, making this metabolite the first reported covalent kinase inhibitor from a bacterium.	Lysine	185-191	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	55-80
23922389-4	2013	A complex between C1s and a collagen-like peptide containing the C1r/C1s-binding motif of C1q shows that the collagen binds to a shallow groove via a critical lysine side chain that contacts Ca(2+)-coordinating residues.	Lysine	159-165	complement C1q A chain	Homo sapiens	90-93
31360909-1	2019	WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation.	Lysine	146-152	lysine methyltransferase 2A	Homo sapiens	103-106
23851690-7	2013	The NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific enrichment of histone 3 lysine 4 trimethylation (H3K4me3), which is indicative of open chromatin state and marks transcription-competent promoters.	Lysine	216-222	CXXC finger protein 1	Homo sapiens	102-106
8745402-3	1996	Catalytic rate measurements on single and double mutants indicate that pK1 is mainly due to the deprotonation of Lys 120 and Lys 134, with only a minor contribution from other surface basic residues, whereas pK2 is due to titration of the invariant Arg 141, likely coupled to deprotonation of the copper-bound water molecule.	Lysine	113-116	prokineticin 1 L homeolog	Xenopus laevis	71-74
23841533-9	2013	We also uncovered, for the first time, the ATP-binding capability of human proliferating cell nuclear antigen (PCNA), identified the lysine residue involved in ATP binding, and validated the protein"s capacity in ATP binding with an independent assay.	Lysine	133-139	proliferating cell nuclear antigen	Homo sapiens	75-109
23841533-9	2013	We also uncovered, for the first time, the ATP-binding capability of human proliferating cell nuclear antigen (PCNA), identified the lysine residue involved in ATP binding, and validated the protein"s capacity in ATP binding with an independent assay.	Lysine	133-139	proliferating cell nuclear antigen	Homo sapiens	111-115
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	catenin beta 1	Homo sapiens	205-217
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	vimentin	Homo sapiens	238-246
23798680-2	2013	Acetylation of the epsilon-amino group of Lys-40 of alpha-tubulin marks stable microtubules, although the causal relationship between tubulin acetylation and microtubule stability has remained poorly understood.	Lysine	42-45	tubulin alpha 1b	Homo sapiens	52-65
8745402-3	1996	Catalytic rate measurements on single and double mutants indicate that pK1 is mainly due to the deprotonation of Lys 120 and Lys 134, with only a minor contribution from other surface basic residues, whereas pK2 is due to titration of the invariant Arg 141, likely coupled to deprotonation of the copper-bound water molecule.	Lysine	125-128	prokineticin 1 L homeolog	Xenopus laevis	71-74
23542129-0	2013	Dual roles for lysine 490 of promyelocytic leukemia protein in the transactivation of glucocorticoid receptor-interacting protein 1.	Lysine	15-21	PML nuclear body scaffold	Homo sapiens	29-59
8567633-4	1996	We found that when lysines 433 and/or 1076 were replaced by methionines in the ATP-binding domains, all these mutations abolished drug-stimulated ATPase activity independent of the MgATP concentrations applied.	Lysine	19-26	dynein axonemal heavy chain 8	Homo sapiens	146-152
23542129-5	2013	Three N-terminal sumoylation residues (Lys 65, 160, and 490) exhibited differential roles in the regulation of GRIP1 activity, and the sumoylation of Lys 490 acted as the primary nuclear localization signal of PML.	Lysine	150-153	PML nuclear body scaffold	Homo sapiens	210-213
31270335-6	2019	Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation.	Lysine	103-109	lysine demethylase 2B	Homo sapiens	49-54
31270335-6	2019	Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation.	Lysine	103-109	lysine demethylase 3B	Homo sapiens	56-61
23688307-1	2013	Jmjd6 (jumonji-domain-containing protein 6) is an Fe(II)- and 2OG (2-oxoglutarate)-dependent oxygenase that catalyses hydroxylation of lysine residues in proteins involved in pre-mRNA splicing.	Lysine	135-141	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
23688307-1	2013	Jmjd6 (jumonji-domain-containing protein 6) is an Fe(II)- and 2OG (2-oxoglutarate)-dependent oxygenase that catalyses hydroxylation of lysine residues in proteins involved in pre-mRNA splicing.	Lysine	135-141	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	7-42
8844764-1	1996	The peptide, Phe-Gly Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH, recently isolated from rat brain, has been suggested to be an endogenous agonist for an orphan, opioid-like receptor (ORL1).	Lysine	41-44	opioid related nociceptin receptor 1	Rattus norvegicus	199-203
23894581-0	2013	A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation.	Lysine	134-140	SAGA complex associated factor 29	Homo sapiens	16-41
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Lysine	258-264	microRNA 506	Homo sapiens	129-140
31087496-9	2019	Interestingly, we finally proved that the sorafenib resistant cells regained sensitivity for sorafenib by EZH2 intervention with miR-124/506 overexpression or EZH2 inhibitor treatment in vitro and in vivo, which will lead to the decreased tri-methylation at lysine 27 of histone H3 (H3K27me3) and increased acetylated lysine 27 of histone H3 (H3K27ac) levels.	Lysine	318-324	microRNA 506	Homo sapiens	129-140
23894581-0	2013	A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation.	Lysine	134-140	SAGA complex associated factor 29	Homo sapiens	43-48
8713793-7	1996	The effect of 6-aminohexanoate on the formation of fibrin degradation products by plasmin and miniplasmin suggests that the high-affinity lysine binding site in the N-terminal kringle domain of plasmin is involved in the interactions with the native polymerized fibrin, whereas the fifth kringle found in both enzymes participates in binding to newly exposed lysine residues.	Lysine	138-144	plasminogen	Homo sapiens	82-89
23894581-1	2013	The SGF29 protein binds to tri-methylated lysine-4 of histone H3 (H3K4me3), which is a histone modification associated with active promoters.	Lysine	42-48	SAGA complex associated factor 29	Homo sapiens	4-9
30714168-5	2019	FBXO16 interacts physically with the C-terminal domain of beta-catenin and promotes its lysine 48-linked polyubiquitination.	Lysine	88-94	catenin beta 1	Homo sapiens	58-70
8713793-7	1996	The effect of 6-aminohexanoate on the formation of fibrin degradation products by plasmin and miniplasmin suggests that the high-affinity lysine binding site in the N-terminal kringle domain of plasmin is involved in the interactions with the native polymerized fibrin, whereas the fifth kringle found in both enzymes participates in binding to newly exposed lysine residues.	Lysine	138-144	plasminogen	Homo sapiens	98-105
23639777-7	2013	Sumoylation of C/EBPalpha at lysine 159 was detected in CBRH-7919 cells with transient overexpressed C/EBPalpha, and Co-IP assay detected that sumoylated C/EBPalpha interacted with more HDAC3 than C/EBPalpha K159L mutant.	Lysine	29-35	CCAAT/enhancer binding protein alpha	Rattus norvegicus	15-25
31267840-6	2019	Furthermore, it reduced the expression of p65-NF-kappaB and acetylation of histone H3 at lysine K14, K56 and K79 residues.	Lysine	89-95	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	42-55
8713793-7	1996	The effect of 6-aminohexanoate on the formation of fibrin degradation products by plasmin and miniplasmin suggests that the high-affinity lysine binding site in the N-terminal kringle domain of plasmin is involved in the interactions with the native polymerized fibrin, whereas the fifth kringle found in both enzymes participates in binding to newly exposed lysine residues.	Lysine	359-365	plasminogen	Homo sapiens	82-89
8634061-6	1995	It is suggested that histone H4 plays a role in maintaining genome integrity through the cell cycle, possibly by a mechanism involving lysine acetylation.	Lysine	135-141	histone H4	Saccharomyces cerevisiae S288C	21-31
31372158-16	2019	Conclusion: Glutamic acid (E) is replaced by Lysine (K) at position number 207 (E207K) mutation at exon 4 of low-density lipoprotein receptor (LDLR) gene may be the causative genetic basis of premature coronary artery disease among Pakistani population.	Lysine	45-51	low density lipoprotein receptor	Homo sapiens	109-141
31372158-16	2019	Conclusion: Glutamic acid (E) is replaced by Lysine (K) at position number 207 (E207K) mutation at exon 4 of low-density lipoprotein receptor (LDLR) gene may be the causative genetic basis of premature coronary artery disease among Pakistani population.	Lysine	45-51	low density lipoprotein receptor	Homo sapiens	143-147
23750919-1	2013	Selective binding of the phosphate-substituted molecular tweezer 1a to protein lysine residues was suggested to explain the inhibition of certain enzymes and the aberrant aggregation of amyloid petide Abeta42 or alpha-synuclein, which are assumed to be responsible for Alzheimer"s and Parkinson"s disease, respectively.	Lysine	79-85	synuclein alpha	Homo sapiens	212-227
23738909-0	2013	Role of lysines in cytochrome c-cardiolipin interaction.	Lysine	8-15	cytochrome c, somatic	Equus caballus	19-31
8720146-1	1995	Transglutaminase (TGase) catalyzes an acyl-transfer reaction between peptidyl glutamine residues and primary amines including the epsilon-amino group of lysine residues in protein.	Lysine	153-159	transglutaminase 1	Homo sapiens	18-23
23803967-7	2013	A new study identified the protein inhibitor of growth 1 (Ing1) as a reader of the active chromatin mark histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	116-122	inhibitor of growth family member 1	Homo sapiens	35-56
23803967-7	2013	A new study identified the protein inhibitor of growth 1 (Ing1) as a reader of the active chromatin mark histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	116-122	inhibitor of growth family member 1	Homo sapiens	58-62
23673926-5	2013	The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), reduction of histone H3 or H4 acetylation and increased trimethylation of histone H3 lysine 9 as well as lysine 27 indicating that AML1-ETO induced heterochromatic silencing of Bcl-2, CEBPA and p14(ARF).	Lysine	199-205	RUNX family transcription factor 1	Homo sapiens	25-29
23673926-5	2013	The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), reduction of histone H3 or H4 acetylation and increased trimethylation of histone H3 lysine 9 as well as lysine 27 indicating that AML1-ETO induced heterochromatic silencing of Bcl-2, CEBPA and p14(ARF).	Lysine	219-225	RUNX family transcription factor 1	Homo sapiens	25-29
31071300-10	2019	In conclusion, we demonstrated that RORalpha could alleviate LPS-induced inflammation and organ injury both in vivo and in vitro by blocking NF-kappaB p65 nuclear translocation and restricting acetylation of NF-kappaB p65 at lysine 310 via the regulation of SIRT1 expression.	Lysine	225-231	interferon regulatory factor 6	Homo sapiens	61-64
7499343-1	1995	Furin is a membrane-associated endoprotease that catalyzes cleavage of precursor proteins at Arg-X-Lys/Arg-Arg sites.	Lysine	99-102	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
31196146-4	2019	Here, we demonstrate that cardiac glycoside proscillaridin A specifically targets MYC overexpressing leukemia cells and leukemia stem cells by causing MYC degradation, epigenetic reprogramming and leukemia differentiation through loss of lysine acetylation.	Lysine	238-244	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-85
22824796-3	2013	Tumor with mutations in IDH1 or IDH2 had lower 5-hydroxymethylcytosine and higher 5-methylcytosine levels, as well as increased dimethylation of histone H3 lysine 79 (H3K79).	Lysine	156-162	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	24-28
23755229-8	2013	APE1/Ref-1 also promotes lysine deacetylation of the SIRT1 target endothelial nitric oxide synthase (eNOS).	Lysine	25-31	sirtuin 1	Mus musculus	53-58
23755229-8	2013	APE1/Ref-1 also promotes lysine deacetylation of the SIRT1 target endothelial nitric oxide synthase (eNOS).	Lysine	25-31	nitric oxide synthase 3, endothelial cell	Mus musculus	66-99
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Lysine	76-82	cerebellar degeneration related protein 2	Homo sapiens	183-187
23755229-9	2013	SIRT1 mutated at cysteines 371 and 374, which renders it non-reducible by APE1/Ref-1, prevents lysine deacetylation of eNOS by APE1/Ref-1.	Lysine	95-101	sirtuin 1	Mus musculus	0-5
23772552-3	2013	In an effort to identify inhibitors of ubiquitin carrier protein 9 (Ubc9)-dependent sumoylation, a high-throughput fluorescence polarization assay was developed, which allows detection of Lys-1201 sumoylation, corresponding to the major site of functional sumoylation within the transcriptional repressor trichorhino-phalangeal syndrome type I protein (TRPS1).	Lysine	188-191	transcriptional repressor GATA binding 1	Homo sapiens	353-358
31000580-2	2019	This post-translational modification (PTM) is typically achieved by E1, E2, and E3 enzymes that sequentially catalyze activation, conjugation, and ligation reactions, respectively, leading to covalent attachment of ubiquitin, usually to lysine residues of substrate proteins.	Lysine	237-243	small nucleolar RNA, H/ACA box 73A	Homo sapiens	68-82
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Lysine	76-82	CDR3	Homo sapiens	197-201
30942468-6	2019	In addition, deletion mutants without RING domain or C-terminus of TRAIP diminished the ability to induce H2B monoubiquitination at lysine 120.	Lysine	132-138	H2B clustered histone 21	Homo sapiens	106-109
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Lysine	241-247	cerebellar degeneration related protein 2	Homo sapiens	183-187
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Lysine	241-247	CDR3	Homo sapiens	197-201
7592688-10	1995	Four serine pairs, all displaying the Arg/Lys-Ser-Ser motif typical of phosphorylation sites, are present in p21/SIIR between positions 31 and 48.	Lysine	42-45	transcription elongation factor A like 1	Homo sapiens	109-112
30992364-7	2019	Electrostatic and hydrophobic characteristics of histidine were both required for tau-microtubule binding, as substitutions with constitutively and positively charged nonaromatic lysine or uncharged alanine greatly reduced or abolished tau-microtubule binding.	Lysine	179-185	microtubule associated protein tau	Homo sapiens	82-85
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	doublecortin like kinase 3	Homo sapiens	228-231
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	receptor activity modifying protein 1	Homo sapiens	232-237
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	doublecortin like kinase 3	Homo sapiens	387-390
23296385-6	2013	We found that P493-6 cells with High Myc expression increased their specific uptake of glutamine, arginine, serine, lysine, and branched-chain amino acids by two- to threefold in comparison to low Myc cells, but exhibited only modest increases in glucose uptake and lactate excretion.	Lysine	116-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
23411464-0	2013	Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome.	Lysine	88-94	Spi-1 proto-oncogene	Homo sapiens	61-65
7592688-10	1995	Four serine pairs, all displaying the Arg/Lys-Ser-Ser motif typical of phosphorylation sites, are present in p21/SIIR between positions 31 and 48.	Lysine	42-45	transcription elongation factor A like 1	Homo sapiens	113-117
23696846-5	2013	We found that mouse p53b, but not p53a, could be SUMOylated by SUMO-1 at lysine 375, which was essential for the protein stability of p53b in a dose-dependent manner.	Lysine	73-79	transformation related protein 53, pseudogene	Mus musculus	20-23
23696846-9	2013	Our results provide strong evidences that modification of p53b by SUMO-1 at lysine 375 was necessary for its activity to induce apoptosis in mouse granulosa cells, and it was involved in the regulation of p53b protein stability and nuclear localization.	Lysine	76-82	transformation related protein 53, pseudogene	Mus musculus	58-61
7545663-8	1995	pH titration experiments of CaM dimethylated with [13C]formaldehyde show that Lys-75 (and Lys-148) experience a large increase in pKa upon peptide binding; this indicates an unraveling of part of the helical linker region of CaM upon cNOS peptide binding.	Lysine	78-81	calmodulin 1	Rattus norvegicus	28-31
23674823-5	2013	USP25 specifically reversed the Lys(48)-linked ubiquitination of TRAF3 that was mediated by the E3 ubiquitin ligase cIAP2 (cellular inhibitor of apoptosis 2).	Lysine	32-35	baculoviral IAP repeat-containing 3	Mus musculus	116-121
23674823-5	2013	USP25 specifically reversed the Lys(48)-linked ubiquitination of TRAF3 that was mediated by the E3 ubiquitin ligase cIAP2 (cellular inhibitor of apoptosis 2).	Lysine	32-35	baculoviral IAP repeat-containing 3	Mus musculus	123-156
23624957-1	2013	Holocarboxylase synthetase (HLCS) is a chromatin protein that facilitates the creation of histone H3 lysine 9-methylation (H3K9me) gene repression marks through physical interactions with the histone methyltransferase EHMT-1.	Lysine	101-107	euchromatic histone lysine methyltransferase 1	Homo sapiens	218-224
31120930-3	2019	RF E3s, such as the Cbl proteins, interact with a ubiquitin-conjugating enzyme (E2) to confer specificity to the ubiquitination process and direct the transfer of ubiquitin from the E2 to one or more lysines on the target proteins.	Lysine	200-207	Cbl proto-oncogene	Homo sapiens	20-23
7545663-8	1995	pH titration experiments of CaM dimethylated with [13C]formaldehyde show that Lys-75 (and Lys-148) experience a large increase in pKa upon peptide binding; this indicates an unraveling of part of the helical linker region of CaM upon cNOS peptide binding.	Lysine	78-81	calmodulin 1	Rattus norvegicus	225-228
7545663-8	1995	pH titration experiments of CaM dimethylated with [13C]formaldehyde show that Lys-75 (and Lys-148) experience a large increase in pKa upon peptide binding; this indicates an unraveling of part of the helical linker region of CaM upon cNOS peptide binding.	Lysine	90-93	calmodulin 1	Rattus norvegicus	28-31
30974121-0	2019	Allosteric Regulation of Cyclin-B Binding by the Charge State of Catalytic Lysine in CDK1 Is Essential for Cell-Cycle Progression.	Lysine	75-81	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	85-89
23547114-6	2013	Moreover, mechanistic insights acquired by chromatin immunoprecipitation demonstrate that IkappaBzeta is directly recruited to the proximal promoter region of the Ccl2 gene and is required for transcription-enhancing histone H3 at lysine-4 trimethylation.	Lysine	231-237	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	Mus musculus	90-101
30974121-3	2019	Here, we report for the first time that CDK1:cyclin-B binding is not default but rather determined by the evolutionarily conserved catalytic residue, lysine-33 in CDK1.	Lysine	150-156	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	40-44
7550325-5	1995	Biotinidase cleaves biocytin to biotin and lysine, thereby completing the biotin cycle.	Lysine	43-49	biotinidase	Homo sapiens	0-11
30974121-3	2019	Here, we report for the first time that CDK1:cyclin-B binding is not default but rather determined by the evolutionarily conserved catalytic residue, lysine-33 in CDK1.	Lysine	150-156	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	163-167
30974121-4	2019	We demonstrate that the charge state of this lysine allosterically remodels the CDK1:cyclin-B interface.	Lysine	45-51	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	80-84
30974121-10	2019	Importantly, cells expressing acetylation mimic mutant of Cdc2/CDK1 in yeast are arrested in G2 and fail to divide, indicating the requirement of the deacetylated state of the catalytic lysine for cell division.	Lysine	186-192	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	63-67
30974121-11	2019	Thus, by illustrating the molecular role of the catalytic lysine and cell cycle-dependent deacetylation as a determinant of CDK1:cyclin-B interaction, our results redefine the current model of CDK1 activation and cell-cycle progression.	Lysine	58-64	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	124-128
30974121-11	2019	Thus, by illustrating the molecular role of the catalytic lysine and cell cycle-dependent deacetylation as a determinant of CDK1:cyclin-B interaction, our results redefine the current model of CDK1 activation and cell-cycle progression.	Lysine	58-64	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	193-197
23479405-3	2013	Previously, the CYP27A1 Lys(358)-isoLG adduct was found in human retina afflicted with age-related macular degeneration.	Lysine	24-27	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	16-23
23479405-8	2013	Thus, modification of Lys(358), a residue involved in redox partner interactions, is the major contributor to isoLG-associated loss of CYP27A1 activity.	Lysine	22-25	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	135-142
7632680-4	1995	The steady-state radical was generated in the labeled samples and in samples with unlabeled PLP by addition of L-lysine.H2SO4 to activated enzyme.	Lysine	111-119	pyridoxal phosphatase	Homo sapiens	92-95
23675307-5	2013	This phenotype is linked to increased expression of the histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2), which results in the down-regulation of the tumor suppressors Msmb and Nkx3.1 through increased methylation of lysine 27 of histone H3 (H3K27) on their promoter regions.	Lysine	230-236	beta-microseminoprotein	Mus musculus	181-185
23675307-5	2013	This phenotype is linked to increased expression of the histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2), which results in the down-regulation of the tumor suppressors Msmb and Nkx3.1 through increased methylation of lysine 27 of histone H3 (H3K27) on their promoter regions.	Lysine	230-236	NK3 homeobox 1	Mus musculus	190-196
31123462-1	2019	Background: In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains.	Lysine	158-164	TNF receptor associated factor 6	Homo sapiens	32-82
31123462-1	2019	Background: In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains.	Lysine	158-164	TNF receptor associated factor 6	Homo sapiens	84-89
31123462-7	2019	Results: Here, we report on a form of TRAF6 ubiquitination that is mediated by c-Cbl, leading to the formation of lysine 48-linked polyubiquitin chains.	Lysine	114-120	TNF receptor associated factor 6	Homo sapiens	38-43
31123462-7	2019	Results: Here, we report on a form of TRAF6 ubiquitination that is mediated by c-Cbl, leading to the formation of lysine 48-linked polyubiquitin chains.	Lysine	114-120	Cbl proto-oncogene	Homo sapiens	79-84
31123462-13	2019	Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.	Lysine	85-91	TNF receptor associated factor 6	Homo sapiens	61-66
31123462-13	2019	Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.	Lysine	85-91	Cbl proto-oncogene	Homo sapiens	72-77
30905411-1	2019	Lysyl hydroxylase 2 (LH2) is an endoplasmic reticulum (ER)-resident enzyme that catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens.	Lysine	111-117	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-19
30905411-1	2019	Lysyl hydroxylase 2 (LH2) is an endoplasmic reticulum (ER)-resident enzyme that catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens.	Lysine	111-117	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	21-24
31043584-6	2019	Mutations of these three lysine sites in XRCC1 abrogated the interaction with beta-TrCP and prolonged the half-life of XRCC1 protein.	Lysine	25-31	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	78-87
30565859-1	2019	Bromodomain-containing protein 4 (BRD4) recognizes the acetylated lysine of histone H4 via its bromodomains, leading to the recruitment of positive transcription elongation factor b.	Lysine	66-72	H4 clustered histone 6	Homo sapiens	76-86
31097364-2	2019	KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine at position 27 in histone 3.	Lysine	31-37	lysine (K)-specific demethylase 6A	Mus musculus	0-5
31097364-2	2019	KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine at position 27 in histone 3.	Lysine	31-37	lysine (K)-specific demethylase 6A	Mus musculus	21-24
31061526-0	2019	KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.	Lysine	31-37	H4 clustered histone 6	Homo sapiens	20-30
31061526-3	2019	C21orf127 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12) in vitro and in vivo.	Lysine	93-99	H4 clustered histone 6	Homo sapiens	106-116
30558513-3	2019	Lysine (K) at codon 171 of PRNP is an inadequately characterized, naturally occurring polymorphism in sheep.	Lysine	0-6	major prion protein	Ovis aries	27-31
31015464-6	2019	Strikingly, an analogous lysine mutation to TMEM16F-F518 in TMEM16A (L543K) is sufficient to confer CaPLSase activity to the Ca2+-activated Cl- channel (CaCC).	Lysine	25-31	anoctamin 1	Homo sapiens	60-67
31015464-6	2019	Strikingly, an analogous lysine mutation to TMEM16F-F518 in TMEM16A (L543K) is sufficient to confer CaPLSase activity to the Ca2+-activated Cl- channel (CaCC).	Lysine	25-31	anoctamin 1	Homo sapiens	125-151
31015464-6	2019	Strikingly, an analogous lysine mutation to TMEM16F-F518 in TMEM16A (L543K) is sufficient to confer CaPLSase activity to the Ca2+-activated Cl- channel (CaCC).	Lysine	25-31	anoctamin 1	Homo sapiens	153-157
31009484-0	2019	Mutation of key lysine residues in the Insert B region of the yeast dynamin Vps1 disrupts lipid binding and causes defects in endocytosis.	Lysine	16-22	dynamin-like GTPase VPS1	Saccharomyces cerevisiae S288C	76-80
31004086-3	2019	This is accompanied by a decrease of the acetylation of lysine 117 within the core domain of the murine p53 protein, which is required for transcriptional induction of apoptosis.	Lysine	56-62	transformation related protein 53, pseudogene	Mus musculus	104-107
31004086-4	2019	Our results support a model in which the effect of GFI1"s regulation of methylation at the c-terminus of p53 is ultimately mediated through control of acetylation at lysine 117 of p53.	Lysine	166-172	transformation related protein 53, pseudogene	Mus musculus	105-108
31004086-4	2019	Our results support a model in which the effect of GFI1"s regulation of methylation at the c-terminus of p53 is ultimately mediated through control of acetylation at lysine 117 of p53.	Lysine	166-172	transformation related protein 53, pseudogene	Mus musculus	180-183
30979887-4	2019	TBX3 overexpression impairs cell growth and migration and we show that TBX3 is directly repressed by the polycomb repressive complex 2 (PRC2), which methylates histone H3 lysine 27 (H3K27me).	Lysine	171-177	T-box transcription factor 3	Homo sapiens	71-75
30788509-4	2019	Mechanistically, through an association with chromatin modulator polycomb repressive complex 2 (PRC2), MALAT1 detached the core component enhancer of zeste homolog 2 (EZH2) from binding with HIV-1 LTR promoter, and thus removed PRC2 complex-mediated methylation of histone H3 on lysine 27 (H3K27me3) and relieved epigenetic silencing of HIV-1 transcription.	Lysine	279-285	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	103-109
30959978-2	2019	Among numerous absorption enhancers, we already reported that a gemini surfactant, sodium dilauramidoglutamide lysine (SLG-30) with two hydrophobic and two hydrophilic moieties, is a novel and promising adjuvant with a high potency in improving the absorption safely.	Lysine	111-117	sialic acid binding Ig like lectin 12	Homo sapiens	119-122
30992691-12	2019	Elevated RNF8 expression promotes the interaction between RARA and RNF8 and induces RARA Lys-48 linkage ubiquitylation and degradation, resulting in attenuated transcriptional activation of RARA.	Lysine	89-92	ring finger protein 8	Homo sapiens	9-13
30670476-4	2019	We previously found that mutating a positively charged lysine residue (K584) in the ion transport pathway to glutamine converted the linear I-V curve of TMEM16A to an outwardly rectifying curve.	Lysine	55-61	anoctamin 1	Homo sapiens	153-160
30819897-7	2019	This study not only demonstrates that HDAC11 has an activity that is much more efficient than the corresponding deacetylase activity, but also expands the physiological functions of HDAC11 and protein lysine fatty acylation, which opens up opportunities to develop HDAC11-specific inhibitors as therapeutics to modulate immune responses.	Lysine	201-207	histone deacetylase 11	Mus musculus	38-44
30893914-5	2019	Our data suggest a similar binding mode of micro-PIIIA at KV1.6 and KV1.1, in which a plethora of hydrogen bonds are formed by the Arg and Lys residues within the alpha-helical core region of micro-PIIIA, with the central pore residues of the channel.	Lysine	139-142	potassium voltage-gated channel subfamily A member 1	Homo sapiens	68-73
30521896-3	2019	For interaction, the three oligopeptides from the HIV gp120 were peptide A 297TRPNNNTRKRIRIQRGPGRA316 with several lysine (K) and arginine (R) in the V3 loop region, peptide B 493PLGVAPTKAKRRVVQREKR511 with several K and R in the C-terminus region, and oligopeptide C 362KQSSGGDPEIVTHSFNCGG380 with few basic amino acids in the CD4 binding domain.	Lysine	115-121	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	54-59
30923526-11	2019	Therefore, we provided evidence that, in the context of the full length C1q protein, a key contribution to the interaction with both PTX3 and IgM is given by the B chain Arg residues that line the side of the gC1q heterotrimer, with a minor participation of a Lys residue located at the apex of gC1q.	Lysine	260-263	complement C1q A chain	Homo sapiens	72-75
30867409-12	2019	This results in increased histone H3 lysine 9 acetylation marks at E2F1-target gene promoters that are required for S-phase progression.	Lysine	37-43	E2F transcription factor 1	Mus musculus	67-71
30832686-1	2019	BACKGROUND: y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal and renal tubular cells.	Lysine	185-191	solute carrier family 7 member 7	Homo sapiens	12-18
30304383-6	2019	Histone H3 Lysine 9 acetylation of Hoxaas3 promoted gene expression.	Lysine	11-17	Hoxa cluster antisense RNA 3	Mus musculus	35-42
30599068-7	2019	Microtubule stabilization was accompanied by enhanced alpha-tubulin acetylation on lysine 40 and the depletion of HDAC6, the major deacetylase for alpha-tubulin lysine 40.	Lysine	83-89	tubulin alpha 1b	Homo sapiens	54-67
30599068-7	2019	Microtubule stabilization was accompanied by enhanced alpha-tubulin acetylation on lysine 40 and the depletion of HDAC6, the major deacetylase for alpha-tubulin lysine 40.	Lysine	161-167	tubulin alpha 1b	Homo sapiens	147-160
30867746-6	2019	Mechanistically, stimulation by IL-6 and TNF-alpha induced the trimethylation of histone H3 lysine 4 (H3K4Me3) at the MASTL promoter to facilitate chromatin accessibility.	Lysine	92-98	microtubule associated serine/threonine kinase like	Homo sapiens	118-123
30863716-5	2019	The interactive binding site residues of H1R are found to be; Lys-191, Tyr-108, Asp-107, Tyr-100, Lys-179, Lys-191, Thr-194, Trp-428, Phe-432, Tyr-458, Hie-450, with most of these shown to be inhibited by naturally-occurring compound curcumin.	Lysine	62-65	histamine receptor H1	Homo sapiens	41-44
30863716-5	2019	The interactive binding site residues of H1R are found to be; Lys-191, Tyr-108, Asp-107, Tyr-100, Lys-179, Lys-191, Thr-194, Trp-428, Phe-432, Tyr-458, Hie-450, with most of these shown to be inhibited by naturally-occurring compound curcumin.	Lysine	98-101	histamine receptor H1	Homo sapiens	41-44
30863716-5	2019	The interactive binding site residues of H1R are found to be; Lys-191, Tyr-108, Asp-107, Tyr-100, Lys-179, Lys-191, Thr-194, Trp-428, Phe-432, Tyr-458, Hie-450, with most of these shown to be inhibited by naturally-occurring compound curcumin.	Lysine	98-101	histamine receptor H1	Homo sapiens	41-44
30763307-5	2019	We find that Sko1 is sumoylated at Lys 567 and, although many of its targets are osmoresponse genes, the level of Sko1 sumoylation is not stress-regulated and the modification does not depend or impinge on its phosphorylation by the osmostress kinase Hog1.	Lysine	35-38	Sko1p	Saccharomyces cerevisiae S288C	13-17
30359161-1	2019	Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC) and the histone methyl transferase DOT1L.	Lysine	99-105	MLLT1 super elongation complex subunit	Homo sapiens	26-29
30699359-7	2019	This process antagonizes phosphorylation of FNIP1, preventing its interaction with Hsp90, and consequently promotes FNIP1 lysine-1119 ubiquitination and proteasomal degradation.	Lysine	122-128	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
30530489-0	2019	Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.	Lysine	0-6	ATP synthase c subunit lysine N-methyltransferase	Homo sapiens	58-65
30530489-4	2019	Interestingly, CRISPR/Cas9-mediated KO of FAM173B in mammalian cells abrogated trimethylation of Lys-43 in ATP synthase c-subunit (ATPSc), a modification previously reported as ubiquitous among metazoans.	Lysine	97-100	ATP synthase c subunit lysine N-methyltransferase	Homo sapiens	42-49
30530489-5	2019	ATPSc methylation was restored by complementing the KO cells with enzymatically active human FAM173B or with a putative FAM173B orthologue from the nematode Caenorhabditis elegans Interestingly, lack of Lys-43 methylation caused aberrant incorporation of ATPSc into the ATP synthase complex and resulted in decreased ATP-generating ability of the complex, as well as decreased mitochondrial respiration.	Lysine	203-206	ATP synthase c subunit lysine N-methyltransferase	Homo sapiens	120-127
30576099-3	2019	Here, we synthesized a lysine-rich CPP named KRP and developed a tumor-targeted drug delivery system (DDS) by linking KRP and doxorubicin (DOX) with stable covalent bonds (thioether bond and amide bond).	Lysine	23-29	myosin light chain kinase	Homo sapiens	45-48
30576099-3	2019	Here, we synthesized a lysine-rich CPP named KRP and developed a tumor-targeted drug delivery system (DDS) by linking KRP and doxorubicin (DOX) with stable covalent bonds (thioether bond and amide bond).	Lysine	23-29	myosin light chain kinase	Homo sapiens	118-121
33405876-5	2019	We show that amyloids of alpha-synuclein formed in the presence and absence of cationic polymers chitosan and amyloid of poly-l-lysine can interact with lentiviral particles and enhance transduction efficiency in cells.	Lysine	121-134	synuclein alpha	Homo sapiens	25-40
30358439-9	2019	Chromatin immunoprecipitation quantitative PCR using an antibody against H3K27ac (histone H3 acetylated at lysine 27; a known HDAC8 substrate and a marker for active enhancers) suggested that HDAC8 inhibition with NCC170 ameliorated TGFbeta1-induced loss of H3K27ac at the PPARgamma gene enhancer.	Lysine	107-113	histone deacetylase 8	Homo sapiens	192-197
30527625-12	2019	Mechanistically, KDM4D catalyzed histone 3 on lysine 9 (H3K9) di-, and tri-demethylation, which promoted TLR4 expression, and subsequently prompted liver fibrogenesis by activating NF-kappaB signaling pathways.	Lysine	46-52	toll like receptor 4	Homo sapiens	105-109
30171029-2	2019	Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival.	Lysine	68-74	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	19-24
30171029-5	2019	Chromatin immunoprecipitation-sequencing and microarray analysis revealed that DOT1L inhibition downregulated histone H3 lysine 79 dimethylation and expression of IRF4-MYC signaling genes in myeloma cells.	Lysine	121-127	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	79-84
30431069-3	2019	HOTAIR recruits polycomb repressive complex 2 (PRC2) to catalyze H3K27me3; however, whether HOTAIR is associated with the acetylation of histone H3 lysine 27, a marker of transcriptional activation, and the mechanisms through which HOTAIR triggers the metastasis of gastric cancer (GC) by epigenetic regulation remain largely unknown.	Lysine	148-154	HOX transcript antisense RNA	Homo sapiens	92-98
30431069-3	2019	HOTAIR recruits polycomb repressive complex 2 (PRC2) to catalyze H3K27me3; however, whether HOTAIR is associated with the acetylation of histone H3 lysine 27, a marker of transcriptional activation, and the mechanisms through which HOTAIR triggers the metastasis of gastric cancer (GC) by epigenetic regulation remain largely unknown.	Lysine	148-154	HOX transcript antisense RNA	Homo sapiens	92-98
30958363-5	2019	Therefore, it is pertinent to understand and link the role of various lysine residues along with their effector molecules, for instance, E3 ligases PARK2 and STUB1 in the ubiquitination cascade.	Lysine	70-76	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	148-153
29779173-1	2019	Glutaric acidemia type I (GA-I) is a neurometabolic disease caused by deficient activity of glutaryl-CoA dehydrogenase (GCDH) that results in accumulation of metabolites derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	183-189	glutaryl-Coenzyme A dehydrogenase	Mus musculus	92-118
29779173-1	2019	Glutaric acidemia type I (GA-I) is a neurometabolic disease caused by deficient activity of glutaryl-CoA dehydrogenase (GCDH) that results in accumulation of metabolites derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	183-189	glutaryl-Coenzyme A dehydrogenase	Mus musculus	120-124
29779173-1	2019	Glutaric acidemia type I (GA-I) is a neurometabolic disease caused by deficient activity of glutaryl-CoA dehydrogenase (GCDH) that results in accumulation of metabolites derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	191-194	glutaryl-Coenzyme A dehydrogenase	Mus musculus	92-118
29779173-1	2019	Glutaric acidemia type I (GA-I) is a neurometabolic disease caused by deficient activity of glutaryl-CoA dehydrogenase (GCDH) that results in accumulation of metabolites derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	191-194	glutaryl-Coenzyme A dehydrogenase	Mus musculus	120-124
30156703-5	2019	In Arabidopsis, HISTONE MONOUBIQUITINATION2 (HUB2) mediates H2B monoubiquitination (H2Bub1), whereas SET DOMAIN GROUP8 (SDG8) catalyzes H3 lysine 36 trimethylation (H3K36me3).	Lysine	139-145	histone-lysine N-methyltransferase	Arabidopsis thaliana	120-124
30552140-3	2018	We mutated all three lysine residues thought to be acetylated in PEPCK1 but were surprised to observe no loss of binding to UBR5 HECT domain.	Lysine	21-27	phosphoenolpyruvate carboxykinase 1	Homo sapiens	65-71
30552140-4	2018	Furthermore, two PEPCK1 truncation variants (74-622 aa and 10-560 aa) lacking these lysine residues were still able to bind with UBR5 and ubiquitinated in HEK293T cells.	Lysine	84-90	phosphoenolpyruvate carboxykinase 1	Homo sapiens	17-23
30552140-4	2018	Furthermore, two PEPCK1 truncation variants (74-622 aa and 10-560 aa) lacking these lysine residues were still able to bind with UBR5 and ubiquitinated in HEK293T cells.	Lysine	84-90	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	129-133
30552140-5	2018	To discover the ubiquitination site(s) of PEPCK1, which is currently unknown, the Lys residues of PEPCK1 were mutated to Ala and the ubiquitination level of the PEPCK1 mutants was assessed.	Lysine	82-85	phosphoenolpyruvate carboxykinase 1	Homo sapiens	42-48
30558131-4	2018	In this research, a robust lysine (CEL) are two typical UPLC-MS/MS method has been developed for the simultaneous determination of CML and CEL in various sections of antler velvet processed with different methods.	Lysine	27-33	carboxyl ester lipase	Homo sapiens	35-38
30558131-4	2018	In this research, a robust lysine (CEL) are two typical UPLC-MS/MS method has been developed for the simultaneous determination of CML and CEL in various sections of antler velvet processed with different methods.	Lysine	27-33	carboxyl ester lipase	Homo sapiens	139-142
30558131-7	2018	The different contents of CML and CEL in the different samples of antler velvet result from the different interactions of the protein and lysine at different temperatures.	Lysine	138-144	carboxyl ester lipase	Homo sapiens	34-37
30518942-8	2018	Trained against the experimental data for lysines from the Fab fragment, the model provided accurate predictions of occupancies at lysine sites from the Fc region and the protein N-terminus (R2 = 0.76).	Lysine	42-49	FA complementation group B	Homo sapiens	59-62
30518942-8	2018	Trained against the experimental data for lysines from the Fab fragment, the model provided accurate predictions of occupancies at lysine sites from the Fc region and the protein N-terminus (R2 = 0.76).	Lysine	42-48	FA complementation group B	Homo sapiens	59-62
30254011-1	2018	Histone H2B lysine 123 mono-ubiquitination (H2Bub1), catalyzed by Rad6 and Bre1 in Saccharomyces cerevisiae, modulates chromatin structure and affects diverse cellular functions.	Lysine	12-18	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	66-70
30089852-4	2018	Here we show that the histone-lysine N-methyltransferase MLL1/WDR5 complexes physically interact with SOX2 and evoke SOX2 proteolysis, possibly through methylation on a potential site lysine 42 (K42).	Lysine	30-36	lysine methyltransferase 2A	Homo sapiens	57-61
29633022-6	2018	Moreover, mutant IDH1 can drive the immortalization and transformation of p53-/pRb-deficient astrocytes by reactivating telomerase and stabilizing telomeres in combination with increased histone lysine methylation and c-Myc/Max binding at the TERT promoter.	Lysine	195-201	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	17-21
30479332-7	2018	Slx5-Slx8-dependent ubiquitination of Yen1 occurs mainly at K714 and mutation of this lysine increases crossover formation during DSB repair and suppresses chromosome segregation defects in a mus81  background.	Lysine	86-92	ring finger protein 4	Homo sapiens	0-4
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	WD repeat domain 77	Homo sapiens	45-50
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	WD repeat domain 77	Homo sapiens	88-93
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	WD repeat domain 77	Homo sapiens	88-93
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	WD repeat domain 77	Homo sapiens	45-50
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	WD repeat domain 77	Homo sapiens	88-93
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	WD repeat domain 77	Homo sapiens	88-93
30323061-4	2018	Transgenic GCN5L1 overexpression in the mouse liver increased protein acetylation levels, and proteomic detection of specific lysine residues identified numerous sites that are co-regulated by GCN5L1 and SIRT3.	Lysine	126-132	sirtuin 3	Mus musculus	204-209
30224386-6	2018	Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover.	Lysine	70-73	jun B proto-oncogene	Mus musculus	48-52
30224386-6	2018	Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover.	Lysine	70-73	jun B proto-oncogene	Mus musculus	107-111
30224386-6	2018	Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover.	Lysine	70-73	jun B proto-oncogene	Mus musculus	107-111
30228180-7	2018	Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5).	Lysine	104-107	growth arrest specific 8	Homo sapiens	28-32
23601638-2	2013	Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark.	Lysine	131-137	methyl-CpG binding domain protein 2	Homo sapiens	43-54
23550162-6	2013	This is supported by site-directed mutagenesis, which identifies two highly conserved, surface-exposed lysine residues in this region of the trimer that are essential for binding, thus revealing structural parallels with the interactions of Complement C1r/C1s, Uegf, BMP-1 (CUB) domain-containing proteins in diverse biological systems such as complement activation, receptor signaling, and transport.	Lysine	103-109	bone morphogenetic protein 1	Homo sapiens	267-272
23576753-5	2013	MS1 Filtering revealed that lysine acetylation of 283 sites in 136 proteins was significantly increased in the absence of SIRT3 (at least twofold).	Lysine	28-34	sirtuin 3	Mus musculus	122-127
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Lysine	32-38	H2B clustered histone 21	Homo sapiens	80-83
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Lysine	32-38	H2B clustered histone 21	Homo sapiens	85-90
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Lysine	32-38	galectin 1	Homo sapiens	150-154
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Lysine	32-38	H2B clustered histone 21	Homo sapiens	85-88
23519668-5	2013	The N atom in the azaalkyl chain of DAAM-3 is located at almost the same position as the N-methyl C atom of the methylated lysine side chain in the substrate-peptide complex structures and stabilizes complex formation by hydrogen bonding to the substrate-binding site residues of SET7/9.	Lysine	123-129	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	280-286
23255161-8	2013	Our results strongly suggest that ITCH interacts with mutant GCase variants and mediates their lysine 48 polyubiquitination and degradation.	Lysine	95-101	glucosylceramidase beta	Homo sapiens	61-66
23172686-4	2013	In osteoclasts, lack of SirT1 promoted osteoclastogenesis in vitro and activated NF-kappaB by increasing acetylation of Lysine 310.	Lysine	120-126	sirtuin 1	Mus musculus	24-29
23460739-8	2013	Accordingly, the mutation of an MBL conserved lysine residue essential for MASP binding (K55) abolished binding to soluble CR1 and CCP22-30.	Lysine	46-52	mannose binding lectin 2	Homo sapiens	32-35
23460739-8	2013	Accordingly, the mutation of an MBL conserved lysine residue essential for MASP binding (K55) abolished binding to soluble CR1 and CCP22-30.	Lysine	46-52	MBL associated serine protease 1	Homo sapiens	75-79
23460739-10	2013	In conclusion, we show that ficolins are new CR1 ligands and propose that MBL/L-ficolin binding involves major ionic interactions between conserved lysine residues of their collagen stalks and surface exposed acidic residues located in CR1 CCP24 and/or CCP25.	Lysine	148-154	mannose binding lectin 2	Homo sapiens	74-77
23481705-0	2013	Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas.	Lysine	10-16	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	68-92
23401860-3	2013	This interaction occurs in the cytoplasm and requires monoubiquitination of an evolutionarily conserved lysine 1147 (K1147) in the immunoglobulin (Ig)-like repeat 10 (R10) of FLNB and the nuclear localization sequence of HDAC7.	Lysine	104-110	filamin B	Homo sapiens	175-179
23401860-3	2013	This interaction occurs in the cytoplasm and requires monoubiquitination of an evolutionarily conserved lysine 1147 (K1147) in the immunoglobulin (Ig)-like repeat 10 (R10) of FLNB and the nuclear localization sequence of HDAC7.	Lysine	104-110	histone deacetylase 7	Homo sapiens	221-226
23365460-3	2013	Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX (Kdm6a) as a novel regulator for hematopoietic cell migration.	Lysine	134-140	lysine (K)-specific demethylase 6A	Mus musculus	156-159
23365460-3	2013	Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX (Kdm6a) as a novel regulator for hematopoietic cell migration.	Lysine	134-140	lysine (K)-specific demethylase 6A	Mus musculus	161-166
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	61-64	NEDD4 E3 ubiquitin protein ligase L homeolog	Xenopus laevis	19-25
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	NEDD4 E3 ubiquitin protein ligase L homeolog	Xenopus laevis	19-25
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	NEDD4 E3 ubiquitin protein ligase L homeolog	Xenopus laevis	19-25
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	NEDD4 E3 ubiquitin protein ligase L homeolog	Xenopus laevis	19-25
22867050-5	2013	RESULTS: Incubation with HNE promoted the oligomerization of recombinant human alpha-synuclein via adduct formation at the lysine and histidine residues.	Lysine	123-129	synuclein alpha	Homo sapiens	79-94
23353890-7	2013	Furthermore, mutation of the Godzilla ubiquitylation target lysines on VAMP3 abrogates the formation of enlarged endosomes induced by either Godzilla or RNF167.	Lysine	60-67	vesicle associated membrane protein 3	Homo sapiens	71-76
23650795-10	2013	Findings of the light microscope and electron microscope showed that the injury severity of pyramidal cells of hippocampal CA 1 and CA 3 regions was moderate 4 h after epileptic seizure and even worse 24 h after seizure in the model group, LY 294002 group and acupuncture+ LY 294002 group, but relatively lighter in the acupuncture group.	Lysine	240-242	carbonic anhydrase 1	Rattus norvegicus	123-127
23650795-10	2013	Findings of the light microscope and electron microscope showed that the injury severity of pyramidal cells of hippocampal CA 1 and CA 3 regions was moderate 4 h after epileptic seizure and even worse 24 h after seizure in the model group, LY 294002 group and acupuncture+ LY 294002 group, but relatively lighter in the acupuncture group.	Lysine	273-275	carbonic anhydrase 1	Rattus norvegicus	123-127
23229543-5	2013	Here, we report that PKR is ISGylated at lysines 69 and 159.	Lysine	41-48	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	21-24
23219819-6	2013	This mutation eliminates the termination codon of the MT-CO1 gene and extends the COI polypeptide by three amino acids (Lys-Gln-Lys) to the C-terminal.	Lysine	120-123	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	54-60
23219819-6	2013	This mutation eliminates the termination codon of the MT-CO1 gene and extends the COI polypeptide by three amino acids (Lys-Gln-Lys) to the C-terminal.	Lysine	120-123	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	82-85
23219819-6	2013	This mutation eliminates the termination codon of the MT-CO1 gene and extends the COI polypeptide by three amino acids (Lys-Gln-Lys) to the C-terminal.	Lysine	128-131	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	54-60
23219819-6	2013	This mutation eliminates the termination codon of the MT-CO1 gene and extends the COI polypeptide by three amino acids (Lys-Gln-Lys) to the C-terminal.	Lysine	128-131	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	82-85
23142645-6	2013	The hinge region (HR) connecting the CD and C-terminal chromoshadow domain (CSD), and the CSD contributed to the selective binding of HP1alpha to histone H3 with trimethylated lysine 9 through weak DNA binding and by suppressing the DNA binding, respectively.	Lysine	176-182	chromobox 5	Homo sapiens	134-142
23142645-7	2013	We propose that not only the specific recognition of lysine 9 methylation of histone H3 by the CD but also the HR and the CSD cooperatively contribute to the selective binding of HP1alpha to histone H3 lysine 9 methylated nucleosomes.	Lysine	53-59	chromobox 5	Homo sapiens	179-187
23142645-7	2013	We propose that not only the specific recognition of lysine 9 methylation of histone H3 by the CD but also the HR and the CSD cooperatively contribute to the selective binding of HP1alpha to histone H3 lysine 9 methylated nucleosomes.	Lysine	202-208	chromobox 5	Homo sapiens	179-187
23247593-12	2013	CONCLUSION: In U266 cells, berberine suppresses NF-kappaB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis.	Lysine	98-104	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	84-88
23085085-1	2013	Histone deacetylase 3 (Hdac3) is a nuclear enzyme that removes acetyl groups from lysine residues in histones and other proteins to epigenetically regulate gene expression.	Lysine	82-88	histone deacetylase 3	Mus musculus	0-21
23085085-1	2013	Histone deacetylase 3 (Hdac3) is a nuclear enzyme that removes acetyl groups from lysine residues in histones and other proteins to epigenetically regulate gene expression.	Lysine	82-88	histone deacetylase 3	Mus musculus	23-28
23484211-2	2013	Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.	Lysine	57-60	CD5 molecule	Homo sapiens	186-189
23439558-5	2013	Moreover, although the Gfap promoter region containing the STAT3-binding site (GSBS) is enriched with transcription-repressive histone modifications, such as methylation of H3 at lysine 9 (H3K9me3) and H3K27me3, the reduction of these modifications in TKO ESCs was not sufficient for binding of STAT3 at GSBS.	Lysine	179-185	glial fibrillary acidic protein	Mus musculus	23-27
23123766-7	2013	However, no significant restoration of FHL1 expression was observed using sodium butyrate, an inhibitor of histone deacetylase and chromatin immunoprecipitation showed that histone H3 lysine 9 in the FHL1 promoter region was significantly acetylated.	Lysine	184-190	four and a half LIM domains 1	Homo sapiens	200-204
23218171-6	2013	The results indicate that a disruption of redox homeostasis in the cerebral cortex and striatum of young Gcdh(-/-) mice exposed to increased Lys diet may possibly represent an important pathomechanism of brain injury in GA I patients under metabolic stress.	Lysine	141-144	glutaryl-Coenzyme A dehydrogenase	Mus musculus	105-109
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	51-57	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	205-210
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	51-57	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	51-57	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	205-210
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	205-210
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23362208-6	2013	Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down- or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression.	Lysine	78-84	histone deacetylase of the RPD3/HDA1 superfamily 18	Arabidopsis thaliana	268-273
23874194-1	2013	Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs.	Lysine	0-6	REST corepressor 1	Homo sapiens	83-89
23086944-0	2012	Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.	Lysine	143-149	serine/threonine kinase 11	Homo sapiens	59-63
23086944-9	2012	Mutation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB1 activity.	Lysine	17-23	serine/threonine kinase 11	Homo sapiens	12-16
23086944-9	2012	Mutation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB1 activity.	Lysine	17-23	serine/threonine kinase 11	Homo sapiens	100-104
23086944-10	2012	Taken together, our results suggest that adduction of LKB1 Lys-97 mediates the inhibitory effect of HNE.	Lysine	59-62	serine/threonine kinase 11	Homo sapiens	54-58
23105108-1	2012	Tubulin acetyltransferase (TAT) acetylates Lys-40 of alpha-tubulin in the microtubule lumen.	Lysine	43-46	tubulin alpha 1b	Homo sapiens	53-66
23047951-4	2012	Our results confirm that the highly enriched specific acetylation of histone H4 at lysine 16 of compensated genes by the histone acetyl transferase subunit MOF induces a more disorganized state of their chromatin.	Lysine	83-89	males absent on the first	Drosophila melanogaster	156-159
22310283-4	2012	Here, we reported that protein kinase A (PKA)-mediated phosphorylation regulates TAL1 interaction with the lysine-specific demethylase (LSD1) that removes methyl group from methylated Lys 4 on histone H3 tails.	Lysine	184-187	TAL bHLH transcription factor 1, erythroid differentiation factor	Homo sapiens	81-85
22729371-4	2012	METHODS: OPG was conjugated via lysine to poly(PEG) and to linear PEG (0.5 kDa and 5 kDa).	Lysine	32-38	TNF receptor superfamily member 11B	Rattus norvegicus	9-12
22891617-4	2012	In this study, we demonstrated for the first time that acetylation levels of histone H3 lysine 9 (H3K9) at the promoter regions of clock genes, such as Dbp, Per2, and Bmal1, in the adipose tissue of ob/ob mice were significantly reduced compared with those of its control C57BL/6J mice.	Lysine	88-94	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	167-172
23013792-4	2012	We identified lysine residue 266 and the major monoubiquitination site 289, both located within the C2 domain required for PTEN membrane association, as SUMO acceptors in PTEN.	Lysine	14-20	phosphatase and tensin homolog	Homo sapiens	123-127
23013792-4	2012	We identified lysine residue 266 and the major monoubiquitination site 289, both located within the C2 domain required for PTEN membrane association, as SUMO acceptors in PTEN.	Lysine	14-20	phosphatase and tensin homolog	Homo sapiens	171-175
23012657-6	2012	In addition, lysine 13 within PTEN, which is required for its ubiquitination by Nedd4-1, was required for exosomal transport of PTEN.	Lysine	13-19	phosphatase and tensin homolog	Homo sapiens	30-34
23012657-6	2012	In addition, lysine 13 within PTEN, which is required for its ubiquitination by Nedd4-1, was required for exosomal transport of PTEN.	Lysine	13-19	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	80-87
23012657-6	2012	In addition, lysine 13 within PTEN, which is required for its ubiquitination by Nedd4-1, was required for exosomal transport of PTEN.	Lysine	13-19	phosphatase and tensin homolog	Homo sapiens	128-132
22771042-5	2012	We have mapped all lysine residues on cohesin"s alpha-kleisin subunit Mcd1 (Scc1) where SUMO can conjugate.	Lysine	19-25	RAD21 cohesin complex component	Homo sapiens	70-74
22771042-5	2012	We have mapped all lysine residues on cohesin"s alpha-kleisin subunit Mcd1 (Scc1) where SUMO can conjugate.	Lysine	19-25	RAD21 cohesin complex component	Homo sapiens	76-80
24213472-7	2012	The Mixed Lineage Leukemia (MLL) protein is an example of a developmentally important protein that controls the epigenetic activation of gene targets in part by methylating histone 3 on lysine 4.	Lysine	186-192	lysine methyltransferase 2A	Homo sapiens	28-31
22578804-6	2012	Furthermore, mild increases of the activities of some respiratory chain complexes (II-III and IV) were observed in heart and skeletal muscle of Gcdh(-/-) and WT mice after Lys administration.	Lysine	172-175	glutaryl-Coenzyme A dehydrogenase	Mus musculus	144-148
22578804-7	2012	However, the most marked effects provoked by Lys administration were marked decreases of the activities of Na(+), K(+)-ATPase in brain and CK in brain and skeletal muscle of Gcdh(-/-) mice.	Lysine	45-48	glutaryl-Coenzyme A dehydrogenase	Mus musculus	174-178
23028370-1	2012	UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family.	Lysine	80-86	lysine (K)-specific demethylase 6A	Mus musculus	0-3
23028370-1	2012	UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family.	Lysine	80-86	lysine (K)-specific demethylase 6A	Mus musculus	5-10
23028370-1	2012	UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family.	Lysine	80-86	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	Mus musculus	16-19
24280696-3	2012	We discuss four mechanisms by which Hsp90 inhibitors can potentially synergize with anti-cancer drugs: by making a drug-resistant protein that is a client for Hsp90 more sensitive to the drug, by increasing chromosomal aneuploidy and the effectiveness of DNA-damaging drugs, by inhibiting Trithorax proteins which trimethylate histone 3 at lysine 4 (H3K4me3) and thereby decreasing expression of tumor promoter genes, and by interacting with the negative elongation factor (NELF) complex in tumors.	Lysine	340-346	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-41
24280696-3	2012	We discuss four mechanisms by which Hsp90 inhibitors can potentially synergize with anti-cancer drugs: by making a drug-resistant protein that is a client for Hsp90 more sensitive to the drug, by increasing chromosomal aneuploidy and the effectiveness of DNA-damaging drugs, by inhibiting Trithorax proteins which trimethylate histone 3 at lysine 4 (H3K4me3) and thereby decreasing expression of tumor promoter genes, and by interacting with the negative elongation factor (NELF) complex in tumors.	Lysine	340-346	heat shock protein 90 alpha family class A member 1	Homo sapiens	159-164
22745130-5	2012	Unexpectedly, the structure of pDCR refined to 1.84 A resolution reveals the absence of the tyrosine-serine pair seen in the active site of mDCR, which together with a lysine and an asparagine have been deemed a hallmark of the SDR family of enzymes.	Lysine	168-174	2,4-dienoyl-CoA reductase 2	Homo sapiens	31-35
22120716-2	2012	We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation.	Lysine	92-99	histone deacetylase 1	Mus musculus	126-131
22771806-4	2012	In addition, histone 3(H3)-acetylation and histone 3 lysine 4 (H3-K4)-methylation greatly increased at the ifng locus of the Th2 cells.	Lysine	53-59	heart and neural crest derivatives expressed 2	Mus musculus	125-128
22707723-8	2012	Immunoprecipitation assays show that Nrdp1 interacts with and ubiquitinates transcriptional factor C/EBPbeta via Lys-63-linked ubiquitination.	Lysine	113-116	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	99-108
22635919-6	2012	The ribosome binding site is identified as a short lysine-rich motif within the amino terminus of the Snl1 BAG domain distinct from the Hsp70 interaction region.	Lysine	51-57	Snl1p	Saccharomyces cerevisiae S288C	102-106
22653977-6	2012	Specifically, beta-catenin modified with lysine-11 ubiquitin chain extension efficiently activates a lymphocyte enhancer-binding factor-T cell factor reporter.	Lysine	41-47	catenin beta 1	Homo sapiens	14-26
22658724-4	2012	We also demonstrate a requirement for PCNA and its modification on lysine 164.	Lysine	67-73	proliferating cell nuclear antigen	Homo sapiens	38-42
22589545-3	2012	Here, we show that RNF8 dimerizes and binds to Ubc13/Mms2, thereby stimulating formation of Lys-63 ubiquitin chains, whereas the related RNF168 RING domain is a monomer and does not catalyze Lys-63 polyubiquitylation.	Lysine	92-95	ring finger protein 8	Homo sapiens	19-23
22589545-3	2012	Here, we show that RNF8 dimerizes and binds to Ubc13/Mms2, thereby stimulating formation of Lys-63 ubiquitin chains, whereas the related RNF168 RING domain is a monomer and does not catalyze Lys-63 polyubiquitylation.	Lysine	92-95	ubiquitin conjugating enzyme E2 N	Homo sapiens	47-52
22589545-3	2012	Here, we show that RNF8 dimerizes and binds to Ubc13/Mms2, thereby stimulating formation of Lys-63 ubiquitin chains, whereas the related RNF168 RING domain is a monomer and does not catalyze Lys-63 polyubiquitylation.	Lysine	191-194	ring finger protein 8	Homo sapiens	19-23
22589545-6	2012	These findings support the hypothesis that RNF8 is responsible for the initiation of Lys-63-linked ubiquitylation in the DNA damage response, which is subsequently amplified by RNF168.	Lysine	85-88	ring finger protein 8	Homo sapiens	43-47
23413682-8	2012	In particular, it was shown that in the mice brain the LAAO-catalyzed reaction is the single pathway of L-lysine degradation, while in the mice milk LAAO carry out the antibacterial effect and in human leucocytes LAAO take part in fulfilling their defending role.	Lysine	104-112	interleukin 4 induced 1	Mus musculus	55-59
22556262-3	2012	Here, we show that SETD8 regulates the function of proliferating cell nuclear antigen (PCNA) protein through lysine methylation.	Lysine	109-115	proliferating cell nuclear antigen	Homo sapiens	51-85
22556262-3	2012	Here, we show that SETD8 regulates the function of proliferating cell nuclear antigen (PCNA) protein through lysine methylation.	Lysine	109-115	proliferating cell nuclear antigen	Homo sapiens	87-91
22556262-4	2012	We found that SETD8 methylated PCNA on lysine 248, and either depletion of SETD8 or substitution of lysine 248 destabilized PCNA expression.	Lysine	39-45	proliferating cell nuclear antigen	Homo sapiens	31-35
22492917-3	2012	The broad heterogeneity in sensitivity to PG9 and PG16, despite closely genetically related envelope glycoproteins issued from single individuals, allowed us to identify two gp120 cross-clade conserved residues, a lysine at position 168 in the V2 loop and an isoleucine at position 215 in the C2 region, whose substitutions were associated with resistance to PG9 and PG16.	Lysine	214-220	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	174-179
24058773-1	2012	STAT5 proteins are activated by tyrosine phosphorylation, but recently further post-translation modifications such as serine/threonine phosphorylation, acetylation at lysine residues or sumoylation in close vicinity of the critical tyrosine residue have been reported.	Lysine	167-173	signal transducer and activator of transcription 5A	Mus musculus	0-5
22593213-3	2012	Here we show that the Mps3 N-terminus is a substrate for the acetyltransferase Eco1/Ctf7 in vitro and in vivo and map the sites of acetylation to three lysine residues adjacent to the Mps3 transmembrane domain.	Lysine	152-158	Mps3p	Saccharomyces cerevisiae S288C	22-26
22402492-5	2012	DNA damage stimulates sumoylation of BMI1 by CBX4 at lysine 88, which is required for the accumulation of BMI1 at DNA damage sites.	Lysine	53-59	chromobox 4	Homo sapiens	45-49
22688645-0	2012	New marks on the block: Set5 methylates H4 lysines 5, 8 and 12.	Lysine	43-50	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	24-28
22688645-2	2012	Using a biochemical approach, we recently identified new methylation marks on the histone H4 tail in budding yeast at lysines 5, 8 and 12, catalyzed by the previously-uncharacterized enzyme Set5.	Lysine	118-125	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	190-194
22688645-3	2012	Genetic studies revealed that Set5 functions in cellular processes that also rely on the global chromatin modifying complexes COMPASS and NuA4, which methylate H3 lysine 4 and acetylate H4 lysines 5, 8 and 12, respectively.	Lysine	189-196	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	30-34
22387187-3	2012	The promoter of nitrite reductase (Pnir) was cloned from LYS-86 and utilized to construct the transposon vector pUT/mini-Tn5-km2-Pnir-gfp.	Lysine	57-60	nitrite reductase small subunit NirD	Pseudomonas stutzeri	16-33
26105271-4	2012	Tissue transglutaminase (tTG) is a prominent member of a family of enzymes that crosslink proteins by catalyzing the formation of an isopeptide bond between the amide group of glutamine and the free amino group of lysine and is believed to play a role in AT1R activation.	Lysine	214-220	transglutaminase 2, C polypeptide	Mus musculus	0-23
26105271-4	2012	Tissue transglutaminase (tTG) is a prominent member of a family of enzymes that crosslink proteins by catalyzing the formation of an isopeptide bond between the amide group of glutamine and the free amino group of lysine and is believed to play a role in AT1R activation.	Lysine	214-220	transglutaminase 2, C polypeptide	Mus musculus	25-28
26105271-4	2012	Tissue transglutaminase (tTG) is a prominent member of a family of enzymes that crosslink proteins by catalyzing the formation of an isopeptide bond between the amide group of glutamine and the free amino group of lysine and is believed to play a role in AT1R activation.	Lysine	214-220	angiotensin II, type I receptor-associated protein	Mus musculus	255-259
22682249-3	2012	Here, we have generated mice bearing lysine to arginine mutations at one (p53(K117R)) or three (p53(3KR); K117R+K161R+K162R) of p53 acetylation sites.	Lysine	37-43	transformation related protein 53, pseudogene	Mus musculus	74-77
22302399-8	2012	It was found that combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with the two possible genotypes of XPD-Asp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Lysine	159-162	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	133-136
22302399-8	2012	It was found that combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with the two possible genotypes of XPD-Asp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Lysine	159-162	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	191-194
22787429-4	2012	According to an in vitro methyltransferase assay, we found that SMYD2 methylates RB1 protein, and liquid chromatography-tandem mass spectrometry analysis revealed lysine 810 of RB1 to be methylated by SMYD2.	Lysine	163-169	SET and MYND domain containing 2	Homo sapiens	64-69
22787429-4	2012	According to an in vitro methyltransferase assay, we found that SMYD2 methylates RB1 protein, and liquid chromatography-tandem mass spectrometry analysis revealed lysine 810 of RB1 to be methylated by SMYD2.	Lysine	163-169	SET and MYND domain containing 2	Homo sapiens	201-206
22787429-7	2012	SMYD2 is an important oncoprotein in various types of cancer, and SMYD2-dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells.	Lysine	101-107	SET and MYND domain containing 2	Homo sapiens	0-5
22787429-7	2012	SMYD2 is an important oncoprotein in various types of cancer, and SMYD2-dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells.	Lysine	101-107	SET and MYND domain containing 2	Homo sapiens	66-71
22654057-2	2012	The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain (AtCERK1-ECD) to activate immune responses.	Lysine	119-125	chitin elicitor receptor kinase 1	Arabidopsis thaliana	76-83
22654057-2	2012	The cell surface receptor chitin elicitor receptor kinase 1 of Arabidopsis (AtCERK1) directly binds chitin through its lysine motif (LysM)-containing ectodomain (AtCERK1-ECD) to activate immune responses.	Lysine	119-125	chitin elicitor receptor kinase 1	Arabidopsis thaliana	162-169
22403398-2	2012	In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.	Lysine	122-125	ubiquitin like modifier activating enzyme 2	Homo sapiens	33-37
30213795-5	2018	Furthermore, we demonstrate that SIRT2 regulates p73 transcriptional activity by deacetylation of its C-terminal lysine residues.	Lysine	113-119	sirtuin 2	Homo sapiens	33-38
30176030-0	2018	Lysine residues control the conformational dynamics of beta 2-glycoprotein I.	Lysine	0-6	apolipoprotein H	Homo sapiens	55-76
30176030-4	2018	A characteristic feature of beta2GPI is the high content of lysine residues.	Lysine	60-66	apolipoprotein H	Homo sapiens	28-36
30176030-5	2018	However, the potential role of lysine in the conformational dynamics of beta2GPI has been poorly investigated.	Lysine	31-37	apolipoprotein H	Homo sapiens	72-80
30176030-10	2018	Using this strategy, we proved that the electrostatic interaction of lysine residues plays a major role in stabilizing the beta2GPI closed conformation, as confirmed by lysine charge distribution calculations.	Lysine	69-75	apolipoprotein H	Homo sapiens	123-131
30176030-10	2018	Using this strategy, we proved that the electrostatic interaction of lysine residues plays a major role in stabilizing the beta2GPI closed conformation, as confirmed by lysine charge distribution calculations.	Lysine	169-175	apolipoprotein H	Homo sapiens	123-131
30367089-6	2018	We also found aberrantly reduced acetylation of several lysine residues on histone H3 and H4 around the promoter regions of multiple TGFbeta pathway genes.	Lysine	56-62	transforming growth factor alpha	Mus musculus	133-140
30190324-8	2018	In a reconstituted system in bacteria, I analyzed HSP90/P23-associated, SMYD2-mediated ERalpha methylation and found that when SMYD2 binds to the molecular chaperones, it considerably increases methylation of Lys-266 in ERalpha.	Lysine	209-212	prostaglandin E synthase 3	Homo sapiens	56-59
22403398-2	2012	In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.	Lysine	122-125	ubiquitin like modifier activating enzyme 2	Homo sapiens	241-245
22403398-2	2012	In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.	Lysine	191-194	ubiquitin like modifier activating enzyme 2	Homo sapiens	33-37
7632680-10	1995	The analysis indicates a distance of &lt; 3.5 A between the 2H at C4" of PLP and the radical center at C alpha lysine.	Lysine	111-117	pyridoxal phosphatase	Homo sapiens	73-76
30135206-5	2018	The mechanism consists of an IFN-induced, Bcl3- and p300-dependent PD-L1 promoter occupancy by Lys-314/315 acetylated p65 NF-kappaB.	Lysine	95-98	BCL3 transcription coactivator	Homo sapiens	42-46
22442143-9	2012	Consistent with the delayed flowering and FT suppression in the OE-AHL22 mutant, histone 3 (H3) acetylation was reduced and H3 lysine 9 dimethylation was elevated in the FT chromatin.	Lysine	127-133	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	170-172
30135206-5	2018	The mechanism consists of an IFN-induced, Bcl3- and p300-dependent PD-L1 promoter occupancy by Lys-314/315 acetylated p65 NF-kappaB.	Lysine	95-98	CD274 molecule	Homo sapiens	67-72
7639510-4	1995	pK1 is lacking in both the modified enzymes and thus can be assigned to activity-linked lysine residues.	Lysine	88-94	prokineticin 1	Bos taurus	0-3
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Lysine	189-195	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	15-19
7544282-1	1995	The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein.	Lysine	26-29	myelin basic protein	Homo sapiens	141-161
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Lysine	189-195	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	79-83
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Lysine	189-195	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	79-83
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	51-55
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	80-84
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	80-84
22549955-1	2012	Monoubiquitination of histone H2B on Lys 123 (H2BK123ub) is a transient histone modification considered to be essential for establishing H3K4 and H3K79 trimethylation by Set1/COMPASS and Dot1, respectively.	Lysine	37-40	H2B clustered histone 21	Homo sapiens	30-33
7622036-5	1995	Thus, the amino-terminal domain of histone H4 has novel genetic functions that depend on the presence of lysine per se, and not a specific primary peptide sequence.	Lysine	105-111	histone H4	Saccharomyces cerevisiae S288C	35-45
22189873-5	2012	An in vitro enzymatic assay monitored by matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry indicates that Jmjd6 is unable to remove the methyl group from histone arginine residues but can hydroxylate the histone H4 tail at lysine residues in a 2-oxoglutarate (2-OG)- and Fe (II)-dependent manner.	Lysine	262-268	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	145-150
29800064-2	2018	Acetylation/de-acetylation of specific lysine residues in Smad2/3 has been shown to regulate TGF-beta signalling by altering its transcriptional activity.	Lysine	39-45	transforming growth factor alpha	Mus musculus	93-101
30120198-6	2018	In a NopM variant lacking any lysine residues, auto-ubiquitination was not completely abolished, indicating noncanonical auto-ubiquitination of the protein.	Lysine	30-36	E3 ubiquitin--protein ligase	Sinorhizobium fredii NGR234	5-9
29939350-10	2018	Serum creatinine levels showed a linear decrease with increasing SID Lys:CP levels (P < 0.001).	Lysine	69-72	ceruloplasmin	Homo sapiens	73-75
7622036-9	1995	These results indicate that the lysine-dependent function of histone H4 is required for the maintenance of genome integrity, and that DNA damage resulting from the loss of this function activates the RAD9-dependent G2/M checkpoint pathway.	Lysine	32-38	histone H4	Saccharomyces cerevisiae S288C	61-71
7608199-5	1995	AAP3 and AAP5 efficiently transport arginine and lysine and are involved in basic amino acid transport.	Lysine	49-55	amino acid permease 3	Arabidopsis thaliana	0-4
29939350-14	2018	The effect of decreasing CP level depends on SID Lys, and using a maximal SID Lys:CP ratio may be useful for optimizing the AA profile of dietary CP.	Lysine	49-52	ceruloplasmin	Homo sapiens	25-27
22445450-6	2012	Following a single intra-peritoneal (IP) injection of lysine (Lys) there was a moderate increase of brain GA concentration in Gcdh(-/-) mice, but no change in WT.	Lysine	54-60	glutaryl-Coenzyme A dehydrogenase	Mus musculus	126-130
22445450-6	2012	Following a single intra-peritoneal (IP) injection of lysine (Lys) there was a moderate increase of brain GA concentration in Gcdh(-/-) mice, but no change in WT.	Lysine	62-65	glutaryl-Coenzyme A dehydrogenase	Mus musculus	126-130
22445450-9	2012	In the striatum, Lys administration provoked a marked increase of lipid peroxidation, DCFH oxidation, SOD and GR activities, as well as significant reductions of GSH levels and GPx activity, with no alteration of sulfhydryl content, CAT and G6PD activities.	Lysine	17-20	glucose-6-phosphate dehydrogenase 2	Mus musculus	241-245
22445450-13	2012	These results indicate that in Gcdh(-/-) mice cerebral tissue, particularly the striatum, is at greater risk for oxidative stress than peripheral tissues following Lys administration.	Lysine	164-167	glutaryl-Coenzyme A dehydrogenase	Mus musculus	31-35
7797559-8	1995	In addition, lysine residues in cathepsin D were shown to be as important for phosphorylation as those in procathepsin L, supporting a general model of the recognition site as a specific three-dimensional arrangement of lysine residues exposed on the surface of lysosomal proteins.	Lysine	13-19	cathepsin D	Homo sapiens	32-43
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	31-37	lysine methyltransferase 2A	Homo sapiens	80-84
29853448-9	2018	After IL-12 stimulation, both STAT1 and STAT4 directly bound on BCL6 and TBX21 gene loci accompanied by suppression of repressive histone mark trimethylated histone 3 lysine 27.	Lysine	167-173	T-box transcription factor 21	Homo sapiens	73-78
22266653-1	2012	In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3.	Lysine	144-147	lysine methyltransferase 2A	Homo sapiens	80-84
7797559-8	1995	In addition, lysine residues in cathepsin D were shown to be as important for phosphorylation as those in procathepsin L, supporting a general model of the recognition site as a specific three-dimensional arrangement of lysine residues exposed on the surface of lysosomal proteins.	Lysine	220-226	cathepsin D	Homo sapiens	32-43
7779780-7	1995	The Nter domain of apo(a) was purified as a soluble protein in a two-step procedure which involved sequential use of a heparin-Sepharose column and a lysine-Sepharose column.	Lysine	150-156	lipoprotein(a)	Homo sapiens	19-25
22393046-0	2012	RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.	Lysine	22-25	Rho GDP dissociation inhibitor alpha	Homo sapiens	0-6
22393046-4	2012	Here, we identified that RhoGDI SUMOylation specifically occurred at Lys-138, which was inhibited by XIAP domain.	Lysine	69-72	Rho GDP dissociation inhibitor alpha	Homo sapiens	25-31
22393046-5	2012	We further demonstrated that RhoGDI SUMOylation at Lys-138 was crucial for inhibiting actin polymerization and cytoskeleton formation as well as cancer cell motility.	Lysine	51-54	Rho GDP dissociation inhibitor alpha	Homo sapiens	29-35
29907572-9	2018	p17 interacts with cyclins by its cyclin-binding motif, 125RXL127 Sequence and mutagenic analyses of p17 indicated that a 140WXFD143 motif and residues Asp-113 and Lys-122 in p17 are critical for CDK2 and CDK6 binding, leading to their sequestration in the cytoplasm.	Lysine	164-167	cyclin B1	Homo sapiens	19-26
29772247-6	2018	Preventing NF-M lysine-serine-proline (KSP) repeat phosphorylation increased internode length by 30% after remyelination.	Lysine	16-22	neurofilament, medium polypeptide	Mus musculus	11-15
22393046-7	2012	Taken together, our study demonstrated a novel modification of RhoGDI, SUMOylation at Lys-138, which played a key role in regulating Rho GTPase activation in cancer cells.	Lysine	86-89	Rho GDP dissociation inhibitor alpha	Homo sapiens	63-69
7779784-2	1995	Over 65% of initial ATPase activity (115 mumol of Pi/(mg.h)) was preserved after complete reaction of the enzyme with the lysine reactive nitroxide spin-labeled TEMPO isothiocyanate (TITC).	Lysine	122-128	dynein axonemal heavy chain 8	Homo sapiens	20-26
7779784-3	1995	In contrast, rapid and complete loss of ATPase activity occurred after reaction of the enzyme with the lysine directed fluorescent probe FITC.	Lysine	103-109	dynein axonemal heavy chain 8	Homo sapiens	40-46
30054507-8	2018	Suppression of DRP1 by HDAC8 was likely mediated by decreasing the level of acetylated histone H3 lysine 27 (a hallmark of active promoters) at the DRP1 promoter.	Lysine	98-104	dynamin 1 like	Homo sapiens	15-19
7779784-9	1995	These findings show that EPR spectroscopy is able to report functionally coupled conformational changes of gastric H/K-ATPase and imply that the spin-labels are attached to lysines within functionally important regions of the enzyme.	Lysine	173-180	dynein axonemal heavy chain 8	Homo sapiens	119-125
30054507-8	2018	Suppression of DRP1 by HDAC8 was likely mediated by decreasing the level of acetylated histone H3 lysine 27 (a hallmark of active promoters) at the DRP1 promoter.	Lysine	98-104	histone deacetylase 8	Homo sapiens	23-28
30054507-8	2018	Suppression of DRP1 by HDAC8 was likely mediated by decreasing the level of acetylated histone H3 lysine 27 (a hallmark of active promoters) at the DRP1 promoter.	Lysine	98-104	dynamin 1 like	Homo sapiens	148-152
22451931-3	2012	Here, we identified key lysine residues (K(38)KKK) within the N-terminal domain of caspase-7 as critical elements for the efficient proteolysis of these two substrates.	Lysine	24-30	caspase 7	Homo sapiens	83-92
22451931-5	2012	Cellular expression of caspase-7 lacking the critical lysine residues resulted in less-efficient PARP and p23 cleavage compared with cells expressing the wild-type peptidase.	Lysine	54-60	caspase 7	Homo sapiens	23-32
22451931-5	2012	Cellular expression of caspase-7 lacking the critical lysine residues resulted in less-efficient PARP and p23 cleavage compared with cells expressing the wild-type peptidase.	Lysine	54-60	prostaglandin E synthase 3	Homo sapiens	106-109
7760048-4	1995	Recent studies by two different laboratories have demonstrated the presence of a cdc2-like kinase [cyclin-dependent kinase-5 (cdk5)] in nervous tissue that selectively phosphorylates KSPXKX and XS/TXK motifs in NF-H and lysine-rich histone (H1).	Lysine	220-226	cyclin-dependent kinase 5	Rattus norvegicus	99-124
22431625-5	2012	In contrast, H3.3 was enriched in actively transcribed genes, especially peaking at the 3" end of genes, and correlated with histone modifications associated with gene activation, such as histone H3 lysine 4 methylation and H2B ubiquitylation, as well as RNA Pol II occupancy.	Lysine	199-205	Histone superfamily protein	Arabidopsis thaliana	13-17
29731425-4	2018	Here, we show that HDAC11 cleaves long-chain acyl modifications on lysine side chains with remarkable efficiency.	Lysine	67-73	histone deacetylase 11	Homo sapiens	19-25
7760048-4	1995	Recent studies by two different laboratories have demonstrated the presence of a cdc2-like kinase [cyclin-dependent kinase-5 (cdk5)] in nervous tissue that selectively phosphorylates KSPXKX and XS/TXK motifs in NF-H and lysine-rich histone (H1).	Lysine	220-226	cyclin-dependent kinase 5	Rattus norvegicus	126-130
7538175-7	1995	However, the sequence Asp-Lys-Gly-Gly (amino acids 44 to 47), also found in the B subunit of PP2A, is dispensable for complex formation between MT and PP2A.	Lysine	26-29	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	93-97
22357541-9	2012	Two mtDNA genes (mitochondrial aspartic acid tRNA (MT-TD), mitochondrial lysine tRNA (MT-TK)) could be involved in the increased risk conferred by the haplogroup B2, as they were upregulated exclusively in B2 tumors (P&lt;0.01, t-test).	Lysine	73-79	mitochondrially encoded tRNA aspartic acid	Homo sapiens	17-49
22357541-9	2012	Two mtDNA genes (mitochondrial aspartic acid tRNA (MT-TD), mitochondrial lysine tRNA (MT-TK)) could be involved in the increased risk conferred by the haplogroup B2, as they were upregulated exclusively in B2 tumors (P&lt;0.01, t-test).	Lysine	73-79	mitochondrially encoded tRNA lysine	Homo sapiens	86-91
7721857-8	1995	Only the cdc34-2 allele, however, could be suppressed by Ub with an amino acid substitution at lysine 48 which is known to be involved in multi-Ub chain assembly.	Lysine	95-101	ubiquitin	Saccharomyces cerevisiae S288C	57-59
22298428-5	2012	Ankrd 13 proteins bound specifically to Lys-63-linked ubiquitin chains, which was consistent with a previous report that EGFR mainly undergoes Lys-63-linked polyubiquitination.	Lysine	40-43	ankyrin repeat domain 13A	Homo sapiens	0-8
22298428-5	2012	Ankrd 13 proteins bound specifically to Lys-63-linked ubiquitin chains, which was consistent with a previous report that EGFR mainly undergoes Lys-63-linked polyubiquitination.	Lysine	143-146	ankyrin repeat domain 13A	Homo sapiens	0-8
22298428-8	2012	We conclude that by binding to the Lys-63-linked polyubiquitin moiety of EGFR at the plasma membrane, Ankrd 13 proteins regulate the rapid internalization of ligand-activated EGFR.	Lysine	35-38	ankyrin repeat domain 13A	Homo sapiens	102-110
29614860-3	2018	We identified an AbetaO-subclass epitope defined by differential solvent orientation of the lysine 28 side chain in a constrained loop of serine-asparagine-lysine (cSNK), rarely displayed in molecular dynamics simulations of monomer and fibril ensembles.	Lysine	92-98	casein kappa	Mus musculus	164-168
29614860-3	2018	We identified an AbetaO-subclass epitope defined by differential solvent orientation of the lysine 28 side chain in a constrained loop of serine-asparagine-lysine (cSNK), rarely displayed in molecular dynamics simulations of monomer and fibril ensembles.	Lysine	156-162	casein kappa	Mus musculus	164-168
7721857-8	1995	Only the cdc34-2 allele, however, could be suppressed by Ub with an amino acid substitution at lysine 48 which is known to be involved in multi-Ub chain assembly.	Lysine	95-101	ubiquitin	Saccharomyces cerevisiae S288C	144-146
22275358-3	2012	The interaction of rhodopsin-attached phosphates with Lys-14 and Lys-15 in beta-strand I was shown to disrupt the interaction of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition into an active receptor-binding state.	Lysine	54-57	S-antigen visual arrestin	Homo sapiens	184-194
7733898-7	1995	Fluorescence quenching studies suggest that it could bind to the ATPase in the vicinity of Cys-344 in the phosphorylation domain and Lys-515 in the nucleotide binding domain.	Lysine	133-136	dynein axonemal heavy chain 8	Homo sapiens	65-71
22247549-3	2012	Here, we show that DM also undergoes post-translational modification through ubiquitination of a single lysine residue present in the cytoplasmic tail of the alpha chain, DMalpha.	Lysine	104-110	major histocompatibility complex, class II, DM alpha	Homo sapiens	171-178
22374424-3	2012	TaqMan RT-PCR was used to evaluate the SNPs of the XRCC3 codon241 (Thr/Met) and XPD codon751 (Lys/Gln) DNA repair genes.	Lysine	94-97	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	80-83
29996811-2	2018	A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in different cancers by inhibiting MYC oncogene.	Lysine	86-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	181-184
29653269-2	2018	c-Myc epigenetically silences tumor suppressors by recruiting PRC2 and inducing methylation of histone H3 lysine 27.	Lysine	106-112	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
7890760-0	1995	Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a).	Lysine	44-50	lipoprotein(a)	Homo sapiens	110-127
7890760-1	1995	The well documented association between high plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular disease might be mediated by the lysine binding of apolipoprotein(a) (apo(a)), the plasminogen-like, multikringle glycoprotein in Lp(a).	Lysine	137-143	lipoprotein(a)	Homo sapiens	62-76
22104404-3	2012	Synthesized ELP exhibited an inverse transition temperature (T(t)) of 40 C in serum with hyperthermia treatment and contained a lysine residue for conjugation with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene-glycol)]-hydroxy succinamide, PEG MW 2000 (DSPE-PEG2000-NHS).	Lysine	128-134	nuclear receptor subfamily 5 group A member 1	Homo sapiens	12-15
7890760-1	1995	The well documented association between high plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular disease might be mediated by the lysine binding of apolipoprotein(a) (apo(a)), the plasminogen-like, multikringle glycoprotein in Lp(a).	Lysine	137-143	lipoprotein(a)	Homo sapiens	78-83
29880196-5	2018	Mutations of lysine residues in calmodulin binding site 2 strongly reduced calmodulin binding and TRPM3 activity indicating the importance of this domain for TRPM3-mediated Ca2+ signaling.	Lysine	13-19	transient receptor potential cation channel subfamily M member 3	Homo sapiens	98-103
7890760-1	1995	The well documented association between high plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular disease might be mediated by the lysine binding of apolipoprotein(a) (apo(a)), the plasminogen-like, multikringle glycoprotein in Lp(a).	Lysine	137-143	lipoprotein(a)	Homo sapiens	155-172
29880196-5	2018	Mutations of lysine residues in calmodulin binding site 2 strongly reduced calmodulin binding and TRPM3 activity indicating the importance of this domain for TRPM3-mediated Ca2+ signaling.	Lysine	13-19	transient receptor potential cation channel subfamily M member 3	Homo sapiens	158-163
7890760-1	1995	The well documented association between high plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular disease might be mediated by the lysine binding of apolipoprotein(a) (apo(a)), the plasminogen-like, multikringle glycoprotein in Lp(a).	Lysine	137-143	lipoprotein(a)	Homo sapiens	174-180
22226905-9	2012	We showed that down-regulation of HDAC1 and the modifications on histone 3 lysine 4 (H3K4) and H3K9 significantly affected microRNA-29b expression.	Lysine	75-81	histone deacetylase 1	Mus musculus	34-39
29695490-4	2018	We found that deleting a H3 histone acetyltransferase Gcn5 or mutating lysines on the H3 tail impairs FACT recruitment at ADH1 and ARG1 genes.	Lysine	71-78	argininosuccinate synthase	Saccharomyces cerevisiae S288C	131-135
7890760-1	1995	The well documented association between high plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular disease might be mediated by the lysine binding of apolipoprotein(a) (apo(a)), the plasminogen-like, multikringle glycoprotein in Lp(a).	Lysine	137-143	lipoprotein(a)	Homo sapiens	234-239
22279139-7	2012	Subsequent chromatin immunoprecipitation analysis further demonstrated that the binding of p300/CBP-associated factor, a coactivator of SREBP-1c, and histone H3 lysine 14 acetylation at the FAS, SCD1, and ACC1 promoters were significantly reduced in the livers of APOE2 mice and HepG2 cells treated with MOEO compared with their controls.	Lysine	161-167	sterol regulatory element binding transcription factor 1	Mus musculus	136-144
7890760-2	1995	We employed a mutational analysis to localize the lysine-binding domains within human apo(a).	Lysine	50-56	lipoprotein(a)	Homo sapiens	86-92
22279139-7	2012	Subsequent chromatin immunoprecipitation analysis further demonstrated that the binding of p300/CBP-associated factor, a coactivator of SREBP-1c, and histone H3 lysine 14 acetylation at the FAS, SCD1, and ACC1 promoters were significantly reduced in the livers of APOE2 mice and HepG2 cells treated with MOEO compared with their controls.	Lysine	161-167	acetyl-Coenzyme A carboxylase alpha	Mus musculus	205-209
7890760-4	1995	The lysine binding of plasma Lp(a) and r-apo(a) in the culture supernatants of transfected HepG2 cells was analyzed by lysine-Sepharose affinity chromatography.	Lysine	4-10	lipoprotein(a)	Homo sapiens	29-34
7890760-4	1995	The lysine binding of plasma Lp(a) and r-apo(a) in the culture supernatants of transfected HepG2 cells was analyzed by lysine-Sepharose affinity chromatography.	Lysine	4-10	lipoprotein(a)	Homo sapiens	41-47
7890760-4	1995	The lysine binding of plasma Lp(a) and r-apo(a) in the culture supernatants of transfected HepG2 cells was analyzed by lysine-Sepharose affinity chromatography.	Lysine	119-125	lipoprotein(a)	Homo sapiens	29-34
7890760-4	1995	The lysine binding of plasma Lp(a) and r-apo(a) in the culture supernatants of transfected HepG2 cells was analyzed by lysine-Sepharose affinity chromatography.	Lysine	119-125	lipoprotein(a)	Homo sapiens	41-47
26889411-4	2012	DNA sequence analysis of the PROS1 gene identified a novel heterozygous nonsense mutation in exon 10 by transition of AAG (lysine) to TAG (stop codon) at codon 473 (c.1417A&gt;T, p.K473X).	Lysine	123-129	protein S	Homo sapiens	29-34
29626535-1	2018	The commercially available antibody-drug conjugate (ADC) product, Kadcyla  is synthesized using a 2-step reaction, wherein the linker is conjugated to native lysines on the mAb in step 1, followed by drug conjugation to the linker-modified antibody in step 2.	Lysine	158-165	antizyme inhibitor 2	Homo sapiens	52-55
7890760-5	1995	Wild type recombinant Lp(a) (r-Lp(a)) revealed lysine binding in the range observed for human plasma Lp(a).	Lysine	47-53	lipoprotein(a)	Homo sapiens	22-27
29626535-2	2018	In our study, we synthesized a lysine-conjugated ADC (Syn-ADC) on the same trastuzumab scaffold as Kadcyla  using a 1-step reaction.	Lysine	31-37	antizyme inhibitor 2	Homo sapiens	49-52
29626535-2	2018	In our study, we synthesized a lysine-conjugated ADC (Syn-ADC) on the same trastuzumab scaffold as Kadcyla  using a 1-step reaction.	Lysine	31-37	antizyme inhibitor 2	Homo sapiens	54-61
22499511-8	2012	Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.	Lysine	9-15	protein interacting with PRKCA 1	Homo sapiens	135-140
22499511-8	2012	Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.	Lysine	9-15	protein interacting with PRKCA 1	Homo sapiens	233-238
7890760-5	1995	Wild type recombinant Lp(a) (r-Lp(a)) revealed lysine binding in the range observed for human plasma Lp(a).	Lysine	47-53	lipoprotein(a)	Homo sapiens	31-36
15299314-5	1995	A probe model composed of the backbone atoms of the N-terminal 77 residues of lysine-, arginine-, ornithine-binding protein (LAO, a total of 238 residues) liganded with lysine correctly finds its position on LAO liganded with histidine which crystallizes as a monomer in the asymmetric unit.	Lysine	78-84	interleukin 4 induced 1	Homo sapiens	125-128
22053931-8	2012	Mutation of this site thus inhibited ubiquitylation of and stabilized p27(Kip1), suggesting that this lysine residue is the target site of p27(Kip1) for ubiquitin conjugation in vivo.	Lysine	102-108	cyclin dependent kinase inhibitor 1B	Homo sapiens	74-78
22053931-8	2012	Mutation of this site thus inhibited ubiquitylation of and stabilized p27(Kip1), suggesting that this lysine residue is the target site of p27(Kip1) for ubiquitin conjugation in vivo.	Lysine	102-108	cyclin dependent kinase inhibitor 1B	Homo sapiens	143-147
29845260-7	2018	Following gene sequencing, two novel heterozygous mutations of the FBN-1 gene were identified: c.3442C&gt;G in exon 27, proline replaced with alanine (p. Pro1148Ala) and c.6388G&gt;A in exon 52, glutamic acid replaced with lysine (p. Glu2130Lys).	Lysine	223-229	fibrillin 1	Homo sapiens	67-72
29915238-5	2018	Mass spectrometric analyses demonstrate that JMJD7 catalyzes Fe(II)- and 2OG-dependent hydroxylation of a highly conserved lysine residue in DRG1/2; amino-acid analyses reveal that JMJD7 catalyzes (3S)-lysyl hydroxylation.	Lysine	123-129	developmentally regulated GTP binding protein 1	Homo sapiens	141-147
15299314-5	1995	A probe model composed of the backbone atoms of the N-terminal 77 residues of lysine-, arginine-, ornithine-binding protein (LAO, a total of 238 residues) liganded with lysine correctly finds its position on LAO liganded with histidine which crystallizes as a monomer in the asymmetric unit.	Lysine	78-84	interleukin 4 induced 1	Homo sapiens	208-211
7814414-0	1995	Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.	Lysine	12-18	insulin receptor	Homo sapiens	92-108
29743353-9	2018	Mutation analyses of all the lysine residues of MAVS further revealed that Lys325 of MAVS is catalyzed by TRIM21 for the K27-linked polyubiquitination.	Lysine	29-35	mitochondrial antiviral signaling protein	Homo sapiens	48-52
29743353-9	2018	Mutation analyses of all the lysine residues of MAVS further revealed that Lys325 of MAVS is catalyzed by TRIM21 for the K27-linked polyubiquitination.	Lysine	29-35	mitochondrial antiviral signaling protein	Homo sapiens	85-89
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	Lysine	127-133	deoxyhypusine synthase	Mus musculus	156-178
21850436-2	2012	Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH).	Lysine	127-133	deoxyhypusine synthase	Mus musculus	180-184
7814414-1	1995	Recently we reported the deletion of Lys-121 in one allele of the insulin receptor gene from a child with severe insulin resistance.	Lysine	37-40	insulin receptor	Homo sapiens	66-82
22654853-12	2012	Therefore we have demonstrated that the activity of the INSL3 peptide is driven predominantly by residues 5-9 in the A-chain, with minor additional contributions from the two C-terminal A-chain residues and Lys-8 in the B-chain.	Lysine	207-210	insulin like 3	Homo sapiens	56-61
30456351-4	2018	Here, we show that SYCE2 constitutively insulates HP1alpha from trimethylated histone H3 lysine 9 (H3K9me3) to promote DNA double-strand break repair.	Lysine	89-95	chromobox 5	Homo sapiens	50-58
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	E1A binding protein p400	Mus musculus	183-187
7814414-8	1995	The results of these and other studies argue that Lys-121 occupies an important position for the regulation of insulin receptor conformation.	Lysine	50-53	insulin receptor	Homo sapiens	111-127
22034497-1	2012	UBC13 is a noncanonical ubiquitin conjugating enzyme (E2) that has been implicated in a variety of cellular signaling processes due to its ability to catalyze formation of lysine 63-linked polyubiquitin chains on various substrates.	Lysine	172-178	ubiquitin conjugating enzyme E2 N	Homo sapiens	0-5
7696559-8	1995	The structures observed in TFE suggest that the Thr-Pro sequence initiates short helical segments in TPAKK motifs, and these helical structures might interact with nucleic acids, presumably via interactions between lysines and threonines of nucleolin.	Lysine	215-222	nucleolin	Homo sapiens	241-250
22307598-0	2012	Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2.	Lysine	33-39	solute carrier family 10 member 4	Homo sapiens	98-114
29900004-4	2018	Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A.Z-depositing complexes, functions as a reader of histone lysine acetylation and recruits Tip60/p400 and SRCAP to deposit H2A.Z into specific chromatin regions including bivalent domains.	Lysine	145-151	Snf2-related CREBBP activator protein	Mus musculus	192-197
29942645-6	2018	Results: We show that Ly-294,002 upregulates bapx1 expression in vivo.	Lysine	22-24	NK3 homeobox 2 S homeolog	Xenopus laevis	45-50
7811262-1	1994	It has been recently reported that the 72 kDa proteolytic enzyme gelatinase A/type IV collagenase/matrix metalloproteinase 2 (MMP2) hydrolyzed the Lys 16-Leu 17 peptide bond of a synthetic decapeptide (YEVHHQKLVFF) representing the soluble A beta sequence of amino acid residues 10-20.	Lysine	147-150	matrix metallopeptidase 2	Homo sapiens	126-130
29721585-1	2018	As a vital member of AAA+ (ATPase associated with diverse cellular activities) protein superfamily, Lon, a homo-hexameric ring-shaped protein complex with a serine-lysine catalytic dyad, is highly conserved throughout almost all prokaryotic and eukaryotic organisms.	Lysine	164-170	lon peptidase 1, mitochondrial	Homo sapiens	100-103
22286100-5	2012	When the number of ubiquitylatable lysines in cyclin B1 is restricted, Lys 11-linked ubiquitin polymers elaborated by UBE2S become increasingly important.	Lysine	35-42	cyclin B1	Homo sapiens	46-55
22190494-12	2012	Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.	Lysine	54-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
7811262-3	1994	Our results indicate that MMP2 hydrolyzes A beta 1-40 and A beta 1-42 peptides at Lys 16-Leu 17, at Leu 34-Met 35, and Met 35-Val 36 peptide bonds.	Lysine	82-85	matrix metallopeptidase 2	Homo sapiens	26-30
22190494-12	2012	Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.	Lysine	54-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	130-135
22190494-12	2012	Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.	Lysine	162-168	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
7999753-0	1994	Residue lysine-34 in GroES modulates allosteric transitions in GroEL.	Lysine	8-14	heat shock protein family E (Hsp10) member 1	Homo sapiens	21-26
22244335-1	2012	Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both the histone methyltransferase COMPASS complex and the cleavage and polyadenylation factor(CPF).	Lysine	167-173	H2B clustered histone 21	Homo sapiens	8-11
29571013-7	2018	In the ternary complex model of Sirt4-NAD+-GDH, the acetylated lysine 171 of GDH is located close to NAD+.	Lysine	63-69	glutamate dehydrogenase 1	Homo sapiens	43-46
7999753-1	1994	The conserved residue Lys-34 in GroES was replaced by alanine and glutamic acid using site-directed mutagenesis.	Lysine	22-25	heat shock protein family E (Hsp10) member 1	Homo sapiens	32-37
29858084-9	2018	Ultimately, miR372 promotes the expression of erbB-2 through PKM2-pH3T11-acetylation on histone H3 lysine 9 (H3K9Ac) pathway.	Lysine	99-105	pyruvate kinase M1/2	Homo sapiens	61-65
7999753-5	1994	This is reflected by a change in the Hill coefficient (at 10 mM K+) from 4.10 (+/- 0.22) in the presence of wild-type GroES to 5.17 (+/- 0.24) and 4.46 (+/- 0.14) in the presence of the GroES mutants Lys-34--&gt;Ala and Lys-34--&gt;Glu, respectively.	Lysine	200-203	heat shock protein family E (Hsp10) member 1	Homo sapiens	118-123
7999753-5	1994	This is reflected by a change in the Hill coefficient (at 10 mM K+) from 4.10 (+/- 0.22) in the presence of wild-type GroES to 5.17 (+/- 0.24) and 4.46 (+/- 0.14) in the presence of the GroES mutants Lys-34--&gt;Ala and Lys-34--&gt;Glu, respectively.	Lysine	220-223	heat shock protein family E (Hsp10) member 1	Homo sapiens	118-123
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	44-47	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	29-33
7999753-10	1994	They suggest that Lys-34 in GroES modulates the allosteric transition in GroEL by stabilizing a relaxed (R)-like state.	Lysine	18-21	heat shock protein family E (Hsp10) member 1	Homo sapiens	28-33
22069318-3	2012	In TGFbeta-stimulated cells, TAK1 undergoes Lys-63-linked polyubiquitination at Lys-34 by TNF receptor-associated factor 6 and is thereby activated.	Lysine	80-83	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	29-33
22069318-4	2012	The aim of this study was to investigate whether TAK1 polyubiquitination at Lys-34 is also essential for NF-kappaB activation via TNF receptor, IL-1 receptor and toll-like receptor 4.	Lysine	76-79	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	49-53
22069318-5	2012	We observed that TAK1 polyubiquitination occurred at Lys-34 and required the E3 ubiquitin ligase TNF receptor-associated factor 6 after stimulation of cells with IL-1beta.	Lysine	53-56	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	17-21
22069318-6	2012	Polyubiquitination of TAK1 also occurred at Lys-34 in cells stimulated by TNF-alpha and LPS, which activates TLR4, as well as in HepG2 and prostate cancer cells stimulated with TGFbeta, which in all cases resulted in NF-kappaB activation.	Lysine	44-47	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	22-26
22072714-0	2012	Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.	Lysine	19-25	PHD finger protein 20	Mus musculus	43-48
29458143-8	2018	Mechanistic studies indicated that SUV39H2 can directly bind to the SLIT1 promoter, suppressing SLIT1 transcription by catalyzing histone H3 lysine 9 (H3K9) tri-methylation.	Lysine	141-147	slit guidance ligand 1	Homo sapiens	68-73
29458143-8	2018	Mechanistic studies indicated that SUV39H2 can directly bind to the SLIT1 promoter, suppressing SLIT1 transcription by catalyzing histone H3 lysine 9 (H3K9) tri-methylation.	Lysine	141-147	slit guidance ligand 1	Homo sapiens	96-101
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Lysine	83-86	matrix metallopeptidase 7	Homo sapiens	302-307
22072714-2	2012	One such molecule, plant homeodomain finger protein 20 (PHF20), uses a Tudor domain to read dimethyl lysine residues and is a known component of the MOF (male absent on the first) histone acetyltransferase protein complex, suggesting it plays a role in the cross-talk between lysine methylation and histone acetylation.	Lysine	101-107	PHD finger protein 20	Mus musculus	19-54
22072714-2	2012	One such molecule, plant homeodomain finger protein 20 (PHF20), uses a Tudor domain to read dimethyl lysine residues and is a known component of the MOF (male absent on the first) histone acetyltransferase protein complex, suggesting it plays a role in the cross-talk between lysine methylation and histone acetylation.	Lysine	101-107	PHD finger protein 20	Mus musculus	56-61
22072714-2	2012	One such molecule, plant homeodomain finger protein 20 (PHF20), uses a Tudor domain to read dimethyl lysine residues and is a known component of the MOF (male absent on the first) histone acetyltransferase protein complex, suggesting it plays a role in the cross-talk between lysine methylation and histone acetylation.	Lysine	276-282	PHD finger protein 20	Mus musculus	19-54
7705967-2	1994	Poly-L-lysine (PLL) was loaded with STN-COONSu and conjugated to polyclonal rabbit immunoglobulin G (IgG) activated with sodium periodate.	Lysine	0-13	immunoglobulin heavy variable V1-62	Mus musculus	83-99
22072714-2	2012	One such molecule, plant homeodomain finger protein 20 (PHF20), uses a Tudor domain to read dimethyl lysine residues and is a known component of the MOF (male absent on the first) histone acetyltransferase protein complex, suggesting it plays a role in the cross-talk between lysine methylation and histone acetylation.	Lysine	276-282	PHD finger protein 20	Mus musculus	56-61
22033876-3	2012	The resulting spectra identified monomethylation of lysine residues as a new tau modification.	Lysine	52-58	microtubule associated protein tau	Homo sapiens	77-80
22033876-4	2012	The methyl-lysine was distributed among seven residues located in the projection and microtubule binding repeat regions of tau protein, with one site, K254, being a substrate for a competing lysine modification, ubiquitylation.	Lysine	11-17	microtubule associated protein tau	Homo sapiens	123-126
7705967-2	1994	Poly-L-lysine (PLL) was loaded with STN-COONSu and conjugated to polyclonal rabbit immunoglobulin G (IgG) activated with sodium periodate.	Lysine	0-13	immunoglobulin heavy variable V1-62	Mus musculus	101-104
22033876-7	2012	Together these data provide the first evidence that tau in neurofibrillary lesions is post-translationally modified by lysine methylation.	Lysine	119-125	microtubule associated protein tau	Homo sapiens	52-55
29760386-6	2018	Moreover, the unique reactivity of N-acyl-N-alkyl sulfonamide enables the rational design of a lysine-targeted covalent inhibitor that shows durable suppression of the activity of Hsp90 in cancer cells.	Lysine	95-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	180-185
7527430-1	1994	We have previously reported that human eosinophil granule major basic protein and synthetic cationic proteins such as poly-L-arginine and poly-L-lysine, can increase airway responsiveness in vivo.	Lysine	138-151	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	39-77
29676907-6	2018	We obtained the first crystal structure, at 2.2 A resolution, of a GCase with a noniminosugar modulator covalently bound, and were able to identify the exact lysine residue modified (Lys346) and reveal an allosteric binding site.	Lysine	158-164	glucosylceramidase beta	Homo sapiens	67-72
21811504-2	2012	Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation.	Lysine	136-142	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	62-68
21811504-2	2012	Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation.	Lysine	136-142	DNA methyltransferase 3 alpha	Homo sapiens	76-82
7528239-5	1994	Sequence analysis identified a single base change in the amino-terminal V1 variable subdomain of keratin 1, which caused a lysine to isoleucine substitution.	Lysine	123-129	keratin 1	Homo sapiens	97-106
22938460-8	2012	In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.37- 0.93).	Lysine	87-90	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	83-86
22938460-8	2012	In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.37- 0.93).	Lysine	91-94	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	30-33
29501774-6	2018	Substitution of R50 with lysine (R50K) reduced Eno-1 association with epithelial caveolar domains, thereby diminishing its exteriorization.	Lysine	25-31	enolase 1	Homo sapiens	47-52
29501774-10	2018	Importantly, Eno-1R50me was essential for cancer cell motility since the replacement of Eno-1 R50 by lysine or the suppression of PRMT 5 activity diminished Eno-1-triggered cell invasion.	Lysine	101-107	enolase 1	Homo sapiens	13-18
22938460-8	2012	In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.37- 0.93).	Lysine	91-94	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	83-86
8077215-6	1994	The corresponding residues in lysosomal acid phosphatase (LAP) are Lys and Gly.	Lysine	67-70	acid phosphatase 2, lysosomal	Homo sapiens	30-56
29769718-5	2018	Serine that is misactivated by AlaRS is captured by the lysine side chains of ANKRD16, which prevents the charging of serine adenylates to tRNAAla and precludes serine misincorporation in nascent peptides.	Lysine	56-62	alanyl-tRNA synthetase	Mus musculus	31-36
8077215-6	1994	The corresponding residues in lysosomal acid phosphatase (LAP) are Lys and Gly.	Lysine	67-70	acid phosphatase 2, lysosomal	Homo sapiens	58-61
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	78-81	T cell receptor alpha constant	Homo sapiens	245-254
29507117-5	2018	SMU1, by acting as a substrate recognition module, binds to H2B and mediates monoubiquitylation at the lysine (K) residue K120 through CRL7SMU1 E3 ligase complex.	Lysine	103-109	H2B clustered histone 21	Homo sapiens	60-63
22570767-5	2012	NFs are phosphorylated on highly conserved lysine-serine-proline (KSP) repeats located along the C-termini of both NF-M and NF-H within myelinated axonal regions.	Lysine	43-49	neurofilament heavy chain	Homo sapiens	124-128
21940714-0	2012	Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.	Lysine	104-110	methyl-CpG binding domain protein 2	Homo sapiens	64-75
21940714-5	2012	Herein, the authors describe the development and optimization of homogeneous LANCE Ultra and AlphaLISA antibody-based assays for measuring the catalytic activity of two epigenetic enzymes acting on lysine 4 of histone H3: SET7/9 methyltransferase and LSD1 demethylase.	Lysine	198-204	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	222-228
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	82-85	T cell receptor alpha constant	Homo sapiens	245-254
21940714-5	2012	Herein, the authors describe the development and optimization of homogeneous LANCE Ultra and AlphaLISA antibody-based assays for measuring the catalytic activity of two epigenetic enzymes acting on lysine 4 of histone H3: SET7/9 methyltransferase and LSD1 demethylase.	Lysine	198-204	methyl-CpG binding domain protein 2	Homo sapiens	256-267
8077227-2	1994	We described here that deletion of the cytoplasmic tail polypeptide sequence (Lys-Lys-Lys-Asn-Ser) of TCR beta-chain (beta CT) results in expression of the truncated beta-chain on the surface of a mature T cell hybridoma line, in the absence of TCR-alpha, as a glycophosphatidylinositol (GPI)-anchored monomeric polypeptide.	Lysine	82-85	T cell receptor alpha constant	Homo sapiens	245-254
8052624-10	1994	The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (human) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like protease that cleaves the indicated Lys-Ile bond.	Lysine	254-257	transmembrane serine protease 15	Bos taurus	160-172
22548154-0	2012	Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene.	Lysine	42-48	insulin-like growth factor 1	Rattus norvegicus	74-79
29662162-4	2018	Our study shows that this conserved tryptophan senses the interaction of Hsp90 with a stringent client protein and transfers this information via a cation-pi interaction with a neighboring lysine.	Lysine	189-195	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
7749384-0	1994	Cleavage of human kininogen fragments at Met-Lys by human tissue kallikrein.	Lysine	45-48	kallikrein 1	Homo sapiens	58-75
29713182-17	2018	SUMO1 modification of PKM2 at Lys-336 site increased glycolysis and promoted its cofactor functions.	Lysine	30-33	pyruvate kinase M1/2	Homo sapiens	22-26
22072751-2	2012	In this study, we demonstrate that Sendai virus (SeV) infection results in the IKKepsilon- or TBK1-mediated phosphorylation of XIAP in vivo at Ser430, resulting in Lys(48)-linked autoubiquitination at Lys322/328 residues, followed by the subsequent proteasomal degradation of XIAP.	Lysine	164-167	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	79-89
22083954-5	2012	We provide the first evidence that HPL-1 interacts with HIS-24 monomethylated at lysine 14 (HIS-24K14me1) and associates in vivo with promoters of genes involved in antimicrobial response.	Lysine	81-87	Histone 24	Caenorhabditis elegans	56-62
8031770-5	1994	A positively charged ring of lysine and arginine side chains encircles the PF4 tetramer sphere, presenting multiple potential sites and orientations for heparin binding.	Lysine	29-35	platelet factor 4	Homo sapiens	75-78
23251702-10	2012	Interestingly, inhibition of E2F1 demethylation using an irreversible inhibitor of lysine-specific demethylase 1 reduced both TMCG/DIPY-mediated RASSF1A expression and apoptosis in MDA-MB-231 cells, suggesting that DNA and protein demethylation may act together to control these molecular and cellular processes.	Lysine	83-89	E2F transcription factor 1	Homo sapiens	29-33
29624498-5	2018	We demonstrate that arginine-to-lysine substitutions conferring an increased sensitivity to TRIM22-dependent ubiquitination accumulated progressively in the NP of seasonal influenza A (H1N1) viruses between 1918 and 2009.	Lysine	32-38	tripartite motif containing 22	Homo sapiens	92-98
29624498-7	2018	We show that four arginine residues present in the NP of the 1918 H1N1 pandemic strain and early postpandemic strains were progressively substituted for by lysines between 1918 and 2009, rendering NP more susceptible to TRIM22-mediated ubiquitination.	Lysine	156-163	tripartite motif containing 22	Homo sapiens	220-226
8022828-4	1994	Lys-70 was identified as the GMP attachment site of the Saccharomyces cerevisiae guanylyltransferase (encoded by the CEG1 gene) by guanylylpeptide sequencing.	Lysine	0-3	mRNA guanylyltransferase	Saccharomyces cerevisiae S288C	117-121
29486207-5	2018	Meanwhile, histone modification abnormalities (decreased acetylation and increased di-methylation of histone 3 Lysine 9) on the HSD11B2 promoter and lower-expression of 11beta-HSD2 were observed.	Lysine	111-117	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	128-135
22427990-6	2012	We observed that plating either primary mouse spinal cord neurons or primary rat hippocampal neurons on N-cadherin recombinant substrate greatly enhances their survival compared to non-specific adhesion on poly-L-lysine.	Lysine	206-219	cadherin 2	Rattus norvegicus	104-114
22442717-8	2012	Dysregulated hepatic FAAH(-/-) lysine acetylation was consistent with their metabolite profiling.	Lysine	31-37	fatty acid amide hydrolase	Mus musculus	21-25
22442717-14	2012	FAAH(-/-) mice had altered hepatic lysine acetylation, the pattern sharing similarities with acetylation changes reported with chronic alcohol treatment.	Lysine	35-41	fatty acid amide hydrolase	Mus musculus	0-4
29432128-5	2018	In this study, we have identified lysine 65 (K65) in Cse4 as a site that regulates sumoylation and ubiquitin-mediated proteolysis of Cse4 by Slx5.	Lysine	34-40	ring finger protein 4	Homo sapiens	141-145
8022828-5	1994	CEG1 genes with substitutions at Lys-70 were unable to support viability in yeast and produced proteins that were not guanylylated in vitro.	Lysine	33-36	mRNA guanylyltransferase	Saccharomyces cerevisiae S288C	0-4
8020183-6	1994	Characterization of the Aab to plg shows that they are directed against the conformational epitopes of plg with some of those epitopes being located in the lysine-binding domain of plg.	Lysine	156-162	plasminogen	Homo sapiens	31-34
29477841-5	2018	We demonstrate lysine 48 specific polyubiquitination and subsequent proteasome dependent degradation of ZSCAN4, which may explain how this key factor is efficiently cleared from the cells.	Lysine	15-21	zinc finger and SCAN domain containing 4	Homo sapiens	104-110
22685397-5	2012	P. gingivalis-induced cleavage of RIPK1 and RIPK2 was inhibited in the presence of a lysine-specific gingipain (Kgp) inhibitor.	Lysine	85-91	receptor interacting serine/threonine kinase 1	Homo sapiens	34-39
22049079-6	2011	It was determined that key residues in human (h) Shh involved in heparin and HSPG syndecan-4 binding and biological activity included the well known cationic Cardin-Weintraub motif (lysines 32-38) but also a previously unidentified major role for lysine 178.	Lysine	182-189	sonic hedgehog signaling molecule	Homo sapiens	49-52
29539416-4	2018	Sumoylation of Prdm16 at lysine 917 by Cbx4 blocks its ubiquitination-mediated degradation, thereby augmenting its stability and thermogenic function.	Lysine	25-31	chromobox 4	Mus musculus	39-43
22049079-6	2011	It was determined that key residues in human (h) Shh involved in heparin and HSPG syndecan-4 binding and biological activity included the well known cationic Cardin-Weintraub motif (lysines 32-38) but also a previously unidentified major role for lysine 178.	Lysine	182-188	sonic hedgehog signaling molecule	Homo sapiens	49-52
22049079-10	2011	The data correlated with reduced Shh multimerization where the Lys-37/38 and/or Lys-178 mutations were examined.	Lysine	63-66	sonic hedgehog signaling molecule	Homo sapiens	33-36
22049079-10	2011	The data correlated with reduced Shh multimerization where the Lys-37/38 and/or Lys-178 mutations were examined.	Lysine	80-83	sonic hedgehog signaling molecule	Homo sapiens	33-36
8020183-6	1994	Characterization of the Aab to plg shows that they are directed against the conformational epitopes of plg with some of those epitopes being located in the lysine-binding domain of plg.	Lysine	156-162	plasminogen	Homo sapiens	103-106
8020183-6	1994	Characterization of the Aab to plg shows that they are directed against the conformational epitopes of plg with some of those epitopes being located in the lysine-binding domain of plg.	Lysine	156-162	plasminogen	Homo sapiens	103-106
8189547-1	1994	Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease recognition (for reviews, see P. J. Barr, Cell 66:1-3, 1991, and Y. Nagai, Trends Microbiol.	Lysine	268-271	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
22106309-4	2011	However, our results show that GLS1 differs from PFKFB3 in that its recognition by APC/C-Cdh1 requires the presence of both a Lys-Glu-Asn box (KEN box) and a destruction box (D box) rather than a KEN box alone.	Lysine	126-129	glutaminase	Homo sapiens	31-35
29520069-4	2018	The HDAC9-MALAT1-BRG1 complex binds chromatin and represses contractile protein gene expression in association with gain of histone H3-lysine 27 trimethylation modifications.	Lysine	135-141	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	10-16
8006045-4	1994	The plasmin activity of plasminogen adsorbed to the lysine-derivatized silica glass and its sulfonated precursor was assessed by both a chromogenic substrate assay and a radioimmunoassay for the plasmin cleavage product of fibrinogen, the B beta 1-42 peptide.	Lysine	52-58	plasminogen	Homo sapiens	4-11
29504933-9	2018	Overall, our study identified lysine acetylation as a novel post-translational modification regulating GSK3 activity.	Lysine	30-36	glycogen synthase kinase 3 beta	Mus musculus	103-107
22016392-4	2011	We show here that disruption of helix 8 in the B(2)R by either C-terminal truncation or just by mutation of a central amino acid (Lys-315) to a helix-breaking proline resulted in strong reduction of surface expression.	Lysine	130-133	bradykinin receptor B2	Homo sapiens	47-52
22021037-3	2011	Mutational studies demonstrated that sumoylation occurs on the lysine residue at position 627 (Lys(627)) of mouse MTF-1.	Lysine	63-69	metal response element binding transcription factor 1	Mus musculus	114-119
22021037-3	2011	Mutational studies demonstrated that sumoylation occurs on the lysine residue at position 627 (Lys(627)) of mouse MTF-1.	Lysine	95-98	metal response element binding transcription factor 1	Mus musculus	114-119
8006045-4	1994	The plasmin activity of plasminogen adsorbed to the lysine-derivatized silica glass and its sulfonated precursor was assessed by both a chromogenic substrate assay and a radioimmunoassay for the plasmin cleavage product of fibrinogen, the B beta 1-42 peptide.	Lysine	52-58	plasminogen	Homo sapiens	24-31
8158274-1	1994	alpha-Melanocyte-stimulating hormone (alpha-MSH1-13) and its COOH-terminal tripeptide alpha-MSH11-13 (Lys Pro Val) inhibit inflammation when administered systemically.	Lysine	102-105	pro-opiomelanocortin-alpha	Mus musculus	0-36
21952235-4	2011	Using chromatin immunoprecipitation analysis, we reveal that Sirt1 directly and negatively regulates Sost gene expression by deacetylating histone 3 at lysine 9 at the Sost promoter.	Lysine	152-158	sirtuin 1	Mus musculus	61-66
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	149-154
29037682-0	2018	l-Lysine and l-arginine inhibit myosin aggregation and interact with acidic amino acid residues of myosin: The role in increasing myosin solubility.	Lysine	0-8	myosin heavy chain 14	Homo sapiens	32-38
29037682-0	2018	l-Lysine and l-arginine inhibit myosin aggregation and interact with acidic amino acid residues of myosin: The role in increasing myosin solubility.	Lysine	0-8	myosin heavy chain 14	Homo sapiens	99-105
29037682-1	2018	The objective of this paper is to investigate the potential affecting mechanisms of l-lysine (Lys)/l-arginine (Arg) on myosin solubility.	Lysine	84-92	myosin heavy chain 14	Homo sapiens	119-125
29037682-1	2018	The objective of this paper is to investigate the potential affecting mechanisms of l-lysine (Lys)/l-arginine (Arg) on myosin solubility.	Lysine	94-97	myosin heavy chain 14	Homo sapiens	119-125
29037682-2	2018	The results showed that both Lys and Arg increased the solubility of myosin at the examined pH values.	Lysine	29-32	myosin heavy chain 14	Homo sapiens	69-75
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Lysine	19-22	myosin heavy chain 14	Homo sapiens	66-72
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	CRK like proto-oncogene, adaptor protein	Homo sapiens	156-160
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	telomerase reverse transcriptase	Homo sapiens	178-183
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Lysine	19-22	myosin heavy chain 14	Homo sapiens	155-161
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Lysine	19-22	myosin heavy chain 14	Homo sapiens	155-161
7509806-2	1994	Biotinidase (EC 3.5.1.12) catalyzes the hydrolysis of biocytin, the product of biotin-dependent carboxylase degradation, to biotin and lysine.	Lysine	135-141	biotinidase	Homo sapiens	0-11
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Lysine	19-22	myosin heavy chain 14	Homo sapiens	155-161
29037682-4	2018	The results indicate that the properties of Lys or Arg that result in an inhibition of myosin aggregation and an interaction with hydrophobic amino acid residues may play important roles in increasing the myosin solubility.	Lysine	44-47	myosin heavy chain 14	Homo sapiens	87-93
22179996-4	2011	Overall, significantly elevated head  and neck cancer risk was associated with XPD Lys751Gln polymorphism when  all studies were pooled into the meta-analysis [(Gln/Gln + Lys/Gln) vs Lys/Lys: OR = 1.12, 95%CI = 1.03-1.22, P &lt; 0.01, heterogeneity P =  0.11].	Lysine	83-86	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	79-82
21963238-6	2011	HOTAIR lncRNA preferentially occupies a GA-rich DNA motif to nucleate broad domains of Polycomb occupancy and histone H3 lysine 27 trimethylation.	Lysine	121-127	HOX transcript antisense RNA	Homo sapiens	0-6
7907864-5	1994	The profile of activities for intact Jurkat cells was Leu &gt; Ala &gt; Lys &gt; Arg, changing in the cytosolic fraction to Lys &gt; or = Arg &gt; Leu = Ala; the profiles for intact HL60 cells and AP-N were identical, namely Ala &gt; Leu &gt; Arg &gt; Lys.	Lysine	72-75	alanyl aminopeptidase, membrane	Homo sapiens	197-201
21880715-2	2011	Here we report that SMYD2 prefers to methylate p53 Lys-370 over histone substrates in vitro.	Lysine	51-54	SET and MYND domain containing 2	Homo sapiens	20-25
21880715-3	2011	Consistently, the level of endogenous p53 Lys-370 monomethylation is significantly elevated when SMYD2 is overexpressed in vivo.	Lysine	42-45	SET and MYND domain containing 2	Homo sapiens	97-102
29337251-4	2018	In this study, we investigated the link between chromatin organization and BMSC migration and demonstrated that OPN-mediated BMSC migration leads to elevated levels of heterochromatin marker histone H3 lysine 27 trimethylation (H3K27me3) through the methyltransferase EZH2.	Lysine	202-208	secreted phosphoprotein 1	Homo sapiens	112-115
8069777-8	1994	Preliminary studies indicate that the presence of a threonine at this position may enhance the interaction of Lp(a) with lysine-Sepharose.	Lysine	121-127	lipoprotein(a)	Homo sapiens	110-115
29360266-0	2018	Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.	Lysine	83-89	lysine demethylase 2B	Homo sapiens	119-124
21917920-0	2011	HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia.	Lysine	42-48	histone deacetylase 4	Homo sapiens	0-5
8106349-3	1994	The results confirm that ODC activity requires the formation of a dimer and that this dimer contains two active sites, each made up from part of one subunit that contains amino acids lysine 69, lysine 169, and histidine 197 and a part of the other subunit that contains cysteine 360.	Lysine	183-189	ornithine decarboxylase 1	Homo sapiens	25-28
21871814-0	2011	Lysine-deficient lymphotoxin-alpha mutant for site-specific PEGylation.	Lysine	0-6	lymphotoxin A	Mus musculus	17-34
21871814-4	2011	Previously, we created phage libraries expressing mutant LTalphas in which the lysine residues of wild-type LTalpha (wtLTalpha) were substituted for other amino acids.	Lysine	79-85	lymphotoxin A	Mus musculus	57-64
21871814-5	2011	Here, we attempted to create a lysine-deficient mutant LTalpha with about the same bioactivity as wtLTalpha by using these libraries and site-specific PEGylation of the N-terminus.	Lysine	31-37	lymphotoxin A	Mus musculus	55-62
21871814-6	2011	We isolated a lysine-deficient mutant LTalpha, LT-K0, with almost identical bioactivity to that of wtLTalpha against mouse LM cells.	Lysine	14-20	lymphotoxin A	Mus musculus	38-45
28493058-8	2018	Preferential truncation of two consecutive, positively charged Lys residues at the C-terminus of the LH1 alpha-polypeptide was observed for the Sr2+-cultured cells.	Lysine	63-66	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	101-104
28493058-11	2018	Limited proteolysis of the native Ca2+-LH1 complex with lysyl protease revealed selective truncations at the Lys residues in both C- and N-terminal extensions of the alpha- and beta-polypeptides.	Lysine	109-112	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	39-42
8106349-3	1994	The results confirm that ODC activity requires the formation of a dimer and that this dimer contains two active sites, each made up from part of one subunit that contains amino acids lysine 69, lysine 169, and histidine 197 and a part of the other subunit that contains cysteine 360.	Lysine	194-200	ornithine decarboxylase 1	Homo sapiens	25-28
8155080-0	1994	[Inhibition of esterase by L-lysine, the activator and fibrinolytic activity of the plasmin-streptokinase activator complex].	Lysine	27-35	plasminogen	Homo sapiens	84-91
29440439-5	2018	We show that a charge-conserved mutation of a lysine located on the surface of DD (K599R in human RIPK1 or K584R in murine RIPK1) blocks RIPK1 activation in necroptosis and RIPK1-dependent apoptosis and the formation of complex II.	Lysine	46-52	receptor interacting serine/threonine kinase 1	Homo sapiens	98-103
8155080-1	1994	The effect of L-lysine on some reactions catalysed by plasmin and the plasmin-streptokinase activator complex has been studied.	Lysine	14-22	plasminogen	Homo sapiens	54-61
21531005-3	2011	Here, we investigated the role of lysine-specific demethylase 1 in mesenchymal tumors.	Lysine	34-40	methyl-CpG binding domain protein 2	Homo sapiens	50-61
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	11-17	plasminogen	Homo sapiens	60-67
21531005-5	2011	By analyzing a total of 468 tumors, we describe for the first time high lysine-specific demethylase 1 expression in several highly malignant sarcomas, including synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors and malignant peripheral nerve sheath tumors.	Lysine	72-78	methyl-CpG binding domain protein 2	Homo sapiens	88-99
29474172-5	2018	Mechanistically, SIRT6 deacetylates p53 at lysine 381 to negatively regulate the stability and activity of p53.	Lysine	43-49	transformation related protein 53	Mus musculus	36-39
29474172-5	2018	Mechanistically, SIRT6 deacetylates p53 at lysine 381 to negatively regulate the stability and activity of p53.	Lysine	43-49	transformation related protein 53	Mus musculus	107-110
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	plasminogen	Homo sapiens	60-67
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	plasminogen	Homo sapiens	60-67
29462142-5	2018	Double mutants of Rnf8 and Scml2 revealed that RNF8-dependent monoubiquitination of histone H2A at Lysine 119 (H2AK119ub) is deubiquitinated by SCML2, demonstrating interplay between RNF8 and SCML2 in ubiquitin regulation.	Lysine	99-105	ring finger protein 8	Homo sapiens	18-22
29462142-5	2018	Double mutants of Rnf8 and Scml2 revealed that RNF8-dependent monoubiquitination of histone H2A at Lysine 119 (H2AK119ub) is deubiquitinated by SCML2, demonstrating interplay between RNF8 and SCML2 in ubiquitin regulation.	Lysine	99-105	ring finger protein 8	Homo sapiens	47-51
21884823-0	2011	Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice.	Lysine	30-36	heart and neural crest derivatives expressed 2	Mus musculus	91-94
8170472-5	1994	In contrast, either a C-terminal truncation of 46 amino acids (delta 382-427) or single point mutations at lysine-382, methionine-383, glutamine-385, or leucine-390 dramatically reduced the ability of hVDR to heterodimerize with RAF.	Lysine	107-113	zinc fingers and homeoboxes 2	Homo sapiens	229-232
21875999-1	2011	Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and Drosophila melanogaster Trithorax (Trx).	Lysine	26-32	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	88-92
8276107-1	1994	We made a mutated progastrin cDNA construct that contains a cleavage site (-Arg(-4)-Arg(-3)-Lys(-2)-Arg-1) specific for the Kex2-like endoprotease furin, located ahead of the bioactive gastrin.	Lysine	92-95	arginase-1	Cricetulus griseus	100-105
21875999-1	2011	Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and Drosophila melanogaster Trithorax (Trx).	Lysine	26-32	defective proventriculus	Drosophila melanogaster	93-100
21875999-1	2011	Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and Drosophila melanogaster Trithorax (Trx).	Lysine	26-32	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	165-169
21875999-1	2011	Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and Drosophila melanogaster Trithorax (Trx).	Lysine	26-32	lysine methyltransferase 2A	Homo sapiens	179-183
29422610-7	2018	These findings suggest a coordinated transcriptional activation of genes in the MMP cluster at 11q22.3 and that acetylation of histone H3 at lysine 9 has an important role in the UVB-dependent enhancement of transcription of MMP genes in this region.	Lysine	141-147	matrix metallopeptidase 1	Homo sapiens	225-228
21900231-7	2011	Superposition of the ternary Naa50p complex with the peptide-bound Gcn5 histone acetyltransferase revealed that the two enzymes share a Gcn5-related N-acetyltransferase fold but differ in their respective substrate-binding grooves such that Naa50p can accommodate only an alpha-amino substrate and not a side chain lysine substrate that is acetylated by lysine acetyltransferase enzymes such as Gcn5.	Lysine	315-321	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	29-35
8187235-9	1994	Since plasminogen bound to carboxy-terminal lysines of progressively degraded fibrin or membranes is readily transformed into plasmin by fibrin-bound t-PA, this mechanism represents the most important pathway for the acceleration and amplification of fibrinolysis.	Lysine	44-51	plasminogen	Homo sapiens	6-13
8187237-2	1994	This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin with the kringle domains of plasminogen, and is further amplified via the interaction of plasminogen kringles with the carboxy-terminal lysine residues of fibrin that are exposed by plasmin cleavage.	Lysine	76-82	plasminogen	Homo sapiens	130-137
29410405-5	2018	Mechanistically, cisplatin induces PFKFB3 acetylation at lysine 472 (K472), which impairs activity of the nuclear localization signal (NLS) and accumulates PFKFB3 in the cytoplasm.	Lysine	57-63	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	35-41
29410405-5	2018	Mechanistically, cisplatin induces PFKFB3 acetylation at lysine 472 (K472), which impairs activity of the nuclear localization signal (NLS) and accumulates PFKFB3 in the cytoplasm.	Lysine	57-63	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	156-162
21981917-4	2011	Interestingly, HAT4 is localized in the Golgi apparatus and displays a substrate preference for lysine residues of free histone H4, including H4K79 and H4K91, that reside in the globular domain of H4.	Lysine	96-102	N-alpha-acetyltransferase 60, NatF catalytic subunit	Homo sapiens	15-19
8187237-2	1994	This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin with the kringle domains of plasminogen, and is further amplified via the interaction of plasminogen kringles with the carboxy-terminal lysine residues of fibrin that are exposed by plasmin cleavage.	Lysine	238-244	plasminogen	Homo sapiens	130-137
8187237-3	1994	By virtue of its marked homology with plasminogen, apo(a), the specific apolipoprotein component of Lp(a), may bind to the lysine sites available for plasminogen on the surface of fibrin and thereby interfere with the fibrinolytic process.	Lysine	123-129	lipoprotein(a)	Homo sapiens	100-105
8187237-7	1994	We have further shown that Lp(a) blocks specifically carboxy-terminal lysine residues on the surface of fibrin.	Lysine	70-76	lipoprotein(a)	Homo sapiens	27-32
8239618-3	1993	Both TEM-10 sequences differed from TEM-1 by substitutions of Ser-162 and Lys-237.	Lysine	74-77	hypothetical protein	Escherichia coli	5-10
21802447-6	2011	Site-directed structural modifications of aprotinin are possible to increase its intracellular targeting of cleavage of highly virulent H5 and H7 hemagglutinins possessing multi-arginine/lysine cleavage site.	Lysine	187-193	pancreatic trypsin inhibitor	Bos taurus	42-51
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Lysine	225-228	serpin family C member 1	Homo sapiens	54-59
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Lysine	236-239	serpin family C member 1	Homo sapiens	54-59
21875153-6	2011	In the protease bound-antithrombin-pentasaccharide complex Lys 114, Pro 12 and Lys 125 form important hydrogen bonding interactions.	Lysine	59-62	serpin family C member 1	Homo sapiens	22-34
29237556-4	2018	Here, we report that FTO undergoes post-translational ubiquitination on Lys-216.	Lysine	72-75	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	21-24
29232121-0	2018	Selectively Targeting the Kinome-Conserved Lysine of PI3Kdelta as a General Approach to Covalent Kinase Inhibition.	Lysine	43-49	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	53-62
21875153-6	2011	In the protease bound-antithrombin-pentasaccharide complex Lys 114, Pro 12 and Lys 125 form important hydrogen bonding interactions.	Lysine	79-82	serpin family C member 1	Homo sapiens	22-34
8259556-1	1993	Recombinant staphylokinase (STAR) is produced as a 136 amino acid protein with NH2-terminal sequence Ser-Ser-Ser (mature STAR, HMW-STAR), which may be converted to lower molecular weight forms (LMW-STAR) by removal of the first six residues (yielding STAR-delta 6 with NH2-terminal Gly-Lys-Tyr-) or the first ten residues (yielding STAR-delta 10 with NH2-terminal Lys-Gly-Asp-).	Lysine	286-289	steroidogenic acute regulatory protein	Homo sapiens	28-32
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	SET and MYND domain containing 2	Homo sapiens	26-31
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	SET and MYND domain containing 2	Homo sapiens	195-200
29352221-1	2018	METTL20 is a seven-beta-strand methyltransferase that is localised to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) beta subunit (ETFB) at lysines 200 and 203.	Lysine	170-177	electron transferring flavoprotein, beta polypeptide	Mus musculus	161-165
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	270-276
8259556-1	1993	Recombinant staphylokinase (STAR) is produced as a 136 amino acid protein with NH2-terminal sequence Ser-Ser-Ser (mature STAR, HMW-STAR), which may be converted to lower molecular weight forms (LMW-STAR) by removal of the first six residues (yielding STAR-delta 6 with NH2-terminal Gly-Lys-Tyr-) or the first ten residues (yielding STAR-delta 10 with NH2-terminal Lys-Gly-Asp-).	Lysine	286-289	cilia and flagella associated protein 97	Homo sapiens	127-130
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	101-104	SET and MYND domain containing 2	Homo sapiens	195-200
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	26-31
7688990-11	1993	Fibrin stimulates plasminogen activation by STAR via mechanisms involving the lysine-binding sites of plasminogen, probably by facilitating the generation of plasmin-STAR complex and by delaying its inhibition at the clot surface.	Lysine	78-84	steroidogenic acute regulatory protein	Homo sapiens	44-48
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	195-200
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	270-276
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	195-200
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	26-31
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	21-25
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	26-31
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	32-36
22028615-7	2011	WHSC1 interacts with some proteins related to the WNT pathway including beta-catenin and transcriptionally regulates CCND1, the target gene of the beta-catenin/Tcf-4 complex, through histone H3 at lysine 36 trimethylation.	Lysine	197-203	catenin beta 1	Homo sapiens	147-159
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	37-41
7688990-11	1993	Fibrin stimulates plasminogen activation by STAR via mechanisms involving the lysine-binding sites of plasminogen, probably by facilitating the generation of plasmin-STAR complex and by delaying its inhibition at the clot surface.	Lysine	78-84	steroidogenic acute regulatory protein	Homo sapiens	166-170
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	43-93
8409766-11	1993	LDL from Lpb5 pigs possessed a smaller proportion of lysine residues titrating at pH 8.9 than did LDL from non-Lpb5 pigs, suggesting that the Lpb5-encoded apoB is altered in a manner affecting the microenvironment of particular lysine residues.	Lysine	53-59	apolipoprotein B	Sus scrofa	155-159
29160738-10	2018	In non-replicated DNA, saturating levels of the 53BP1 binding site, di-methylated lysine 20 of histone 4 (H4K20me2), lead to robust 53BP1-RIF1-MAD2L2 recruitment at DSBs, with consequent exclusion of BRCA1.	Lysine	82-88	tumor protein p53 binding protein 1	Homo sapiens	48-53
29160738-10	2018	In non-replicated DNA, saturating levels of the 53BP1 binding site, di-methylated lysine 20 of histone 4 (H4K20me2), lead to robust 53BP1-RIF1-MAD2L2 recruitment at DSBs, with consequent exclusion of BRCA1.	Lysine	82-88	tumor protein p53 binding protein 1	Homo sapiens	132-137
29160738-10	2018	In non-replicated DNA, saturating levels of the 53BP1 binding site, di-methylated lysine 20 of histone 4 (H4K20me2), lead to robust 53BP1-RIF1-MAD2L2 recruitment at DSBs, with consequent exclusion of BRCA1.	Lysine	82-88	mitotic arrest deficient 2 like 2	Homo sapiens	143-149
21784112-0	2011	Interplay of salicylaldehyde, lysine, and M2+ ions on alpha-synuclein aggregation: cancellation of aggregation effects and determination of salicylaldehyde neurotoxicity.	Lysine	30-36	synuclein alpha	Homo sapiens	54-69
21784112-1	2011	In this study, alpha-synuclein was treated in vitro with salicylaldehyde (SA), lysine (lys) and M(n+) (Cu(2+) or Zn(2+)) in various ratios.	Lysine	79-85	synuclein alpha	Homo sapiens	15-30
21784112-1	2011	In this study, alpha-synuclein was treated in vitro with salicylaldehyde (SA), lysine (lys) and M(n+) (Cu(2+) or Zn(2+)) in various ratios.	Lysine	79-82	synuclein alpha	Homo sapiens	15-30
21784112-3	2011	Free lys can thus scavenge SA, inhibiting the aggregation of alpha-syn up to ~63% (alpha-syn:SA:lys=1:1000:5000).	Lysine	5-8	synuclein alpha	Homo sapiens	61-70
21784112-3	2011	Free lys can thus scavenge SA, inhibiting the aggregation of alpha-syn up to ~63% (alpha-syn:SA:lys=1:1000:5000).	Lysine	5-8	synuclein alpha	Homo sapiens	83-92
21784112-3	2011	Free lys can thus scavenge SA, inhibiting the aggregation of alpha-syn up to ~63% (alpha-syn:SA:lys=1:1000:5000).	Lysine	96-99	synuclein alpha	Homo sapiens	61-70
8409766-11	1993	LDL from Lpb5 pigs possessed a smaller proportion of lysine residues titrating at pH 8.9 than did LDL from non-Lpb5 pigs, suggesting that the Lpb5-encoded apoB is altered in a manner affecting the microenvironment of particular lysine residues.	Lysine	228-234	apolipoprotein B	Sus scrofa	155-159
21757742-8	2011	We also found that Tyk2 is preferentially Lys-63 polyubiquitinated and that this activation reaction is inhibited by SOCS1.	Lysine	42-45	suppressor of cytokine signaling 1	Homo sapiens	117-122
8329699-5	1993	These effects were directly proportional to the amount of Lp(a) bound to the carboxy-terminal lysine residues of degraded fibrin.	Lysine	94-100	lipoprotein(a)	Homo sapiens	58-63
21795702-6	2011	Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro.	Lysine	62-65	cyclin dependent kinase inhibitor 1B	Homo sapiens	102-106
21884927-1	2011	Histone H3 lysine 4 trimethylation needed for transcription is mediated by the Set1 methyltransferase and requires prior monoubiquitination of histone H2B.	Lysine	11-17	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	79-83
29975939-2	2018	Histone acetyltransferase (HAT) Mof, specifically acetylating lysine 16 of histone H4 (H4K16), has been reported to regulate T cell differentiation.	Lysine	62-68	K(lysine) acetyltransferase 8	Mus musculus	32-35
8323289-0	1993	Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.	Lysine	8-14	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	51-55
29292490-1	2018	Glutaric aciduria type 1 (GA1) is an autosomal recessive rare disorder caused by mutations in the GCDH gene resulting in deficiency of glutaryl-CoA dehydrogenase, leading to accumulation of the amino acids lysine, hydroxylysine and tryptophan and other metabolites.	Lysine	206-212	glutaryl-CoA dehydrogenase	Homo sapiens	98-102
21642393-7	2011	Comparative modeling with OATP1A2 and OATP2B1 revealed that the pore size around this lysine residue is larger in OATP1A2 and smaller in OATP2B1 compared with OATP1B3, which could be related to the respective substrate spectra.	Lysine	86-92	solute carrier organic anion transporter family member 2B1	Homo sapiens	38-45
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	early growth response 1	Homo sapiens	272-277
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	early growth response 1	Homo sapiens	129-134
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Lysine	78-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	early growth response 1	Homo sapiens	266-271
29623821-6	2018	Dietary lysine restriction enhanced meat color lightness and upregulated SLC7A2 expression.	Lysine	8-14	solute carrier family 7 member 2	Sus scrofa	73-79
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Lysine	78-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	145-149
8323289-2	1993	Acetylation of 2.2 and 8.5 mol of lysine/mole of P450 by acetic anhydride led to 38.7 and 95% reductions, respectively, in benzphetamine demethylation activity by NADPH-dependent reconstituted P450/reductase complex, while modification of up to 8.5 mol of lysine/mol of P450 did not inhibit cumene hydroperoxide-supported P450-dependent benzphetamine demethylation.	Lysine	34-40	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	49-53
21734303-4	2011	The RING domain promotes ubiquitination in vitro and Lys-63-specific ubiquitination of the LDLR in vivo in response to IDOL or liver X receptor activation.	Lysine	53-56	low density lipoprotein receptor	Homo sapiens	91-95
8323289-2	1993	Acetylation of 2.2 and 8.5 mol of lysine/mole of P450 by acetic anhydride led to 38.7 and 95% reductions, respectively, in benzphetamine demethylation activity by NADPH-dependent reconstituted P450/reductase complex, while modification of up to 8.5 mol of lysine/mol of P450 did not inhibit cumene hydroperoxide-supported P450-dependent benzphetamine demethylation.	Lysine	34-40	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	193-197
21734303-4	2011	The RING domain promotes ubiquitination in vitro and Lys-63-specific ubiquitination of the LDLR in vivo in response to IDOL or liver X receptor activation.	Lysine	53-56	myosin regulatory light chain interacting protein	Homo sapiens	119-123
30375897-0	2018	Falsely high HbA1c value due to a novel alpha1-globin gene mutation: Hb shantou [alpha127(H10)Lys &gt; Glu; HBA1: c.382 A &gt; G].	Lysine	94-97	adrenoceptor alpha 1D	Homo sapiens	40-46
8323289-2	1993	Acetylation of 2.2 and 8.5 mol of lysine/mole of P450 by acetic anhydride led to 38.7 and 95% reductions, respectively, in benzphetamine demethylation activity by NADPH-dependent reconstituted P450/reductase complex, while modification of up to 8.5 mol of lysine/mol of P450 did not inhibit cumene hydroperoxide-supported P450-dependent benzphetamine demethylation.	Lysine	34-40	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	193-197
30375897-14	2018	By Sanger sequencing, we identified a transition mutation in the alpha1 gene Hb Shantou [alpha127(H10)Lys &gt; Glu; HBA1: c.382 A &gt; G].	Lysine	102-105	adrenoceptor alpha 1D	Homo sapiens	65-71
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	95-101	nuclear factor of activated T cells 2	Homo sapiens	57-63
8323289-2	1993	Acetylation of 2.2 and 8.5 mol of lysine/mole of P450 by acetic anhydride led to 38.7 and 95% reductions, respectively, in benzphetamine demethylation activity by NADPH-dependent reconstituted P450/reductase complex, while modification of up to 8.5 mol of lysine/mol of P450 did not inhibit cumene hydroperoxide-supported P450-dependent benzphetamine demethylation.	Lysine	34-40	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	193-197
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	111-114	nuclear factor of activated T cells 2	Homo sapiens	57-63
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	119-122	nuclear factor of activated T cells 2	Homo sapiens	57-63
8323289-2	1993	Acetylation of 2.2 and 8.5 mol of lysine/mole of P450 by acetic anhydride led to 38.7 and 95% reductions, respectively, in benzphetamine demethylation activity by NADPH-dependent reconstituted P450/reductase complex, while modification of up to 8.5 mol of lysine/mol of P450 did not inhibit cumene hydroperoxide-supported P450-dependent benzphetamine demethylation.	Lysine	256-262	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	49-53
8323289-9	1993	These results support the hypothesis of a predominant role of lysine residues of P450 in the electrostatic interaction with NADPH-cytochrome P450 reductase.	Lysine	62-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	81-85
8405897-6	1993	The sequence His-Ala-Asp-Gly-Thr5-Phe-Thr-Asn-Asp-Met10-Thr-Ser-Tyr- Leu-Asp15-Ala-Lys-Ala-Ala-Arg20-Asp-Phe-Val-Ser-Trp25- Leu-Ala-Arg-Ser-Asp30- Lys-Ser shows 16 amino acid substitutions compared with the corresponding region of mammalian GLP-1 and 15 substitutions compared with that of salmon GLP.	Lysine	83-86	glucagon like peptide 1 receptor	Homo sapiens	241-246
21764752-0	2011	The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.	Lysine	62-68	RUNX family transcription factor 1	Homo sapiens	23-27
29281621-3	2017	In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitination at lysine 164 promotes recruitment of TLS polymerases, allowing cells to efficiently cope with DNA damage.	Lysine	63-69	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	15-19
29225035-6	2017	Preventing ATF3 ubiquitination by mutating target lysines prevented recovery of transcription and increased cell death following UV treatment.	Lysine	50-57	activating transcription factor 3	Homo sapiens	11-15
21586674-6	2011	SLC7A7 gene silencing causes a significant reduction of system y(+)L activity and a subsequent, marked increase of arginine and lysine cell content, thus suggesting that in macrophagic cells, system y(+)L activity is mainly directed outwardly.	Lysine	128-134	solute carrier family 7 member 7	Homo sapiens	0-6
8505318-3	1993	From predictions based on known substrates it was concluded that amino acids Lys or Ser in place of Gln at position 7 would prevent cleavage at the Leu5-Trp6 peptide bond, therefore stabilizing the protein.	Lysine	77-80	transient receptor potential cation channel subfamily C member 6	Homo sapiens	153-157
21678921-1	2011	SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferase that catalyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residues on histones and other proteins.	Lysine	62-68	SET and MYND domain containing 2	Homo sapiens	0-40
21678921-1	2011	SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferase that catalyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residues on histones and other proteins.	Lysine	62-68	SET and MYND domain containing 2	Homo sapiens	42-47
29225200-2	2017	During sumoylation, SUMO proteins are covalently attached to the epsilon-amino group of lysine in target proteins via an enzymatic cascade that requires the sequential action of E1, E2 and E3 enzymes.	Lysine	88-94	small nucleolar RNA, H/ACA box 73A	Homo sapiens	178-190
7683664-6	1993	When mixtures of plasmin and STAR were adsorbed to lysine-Sepharose, STAR adsorbed quantitatively (96 +/- 1%) to the gel, whereas it was nearly quantitatively recovered in the unbound fraction (92 +/- 4%) after addition of alpha 2-antiplasmin to the mixture.	Lysine	51-57	plasminogen	Homo sapiens	17-24
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	lysine methyltransferase 2A	Homo sapiens	39-42
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	lysine methyltransferase 2A	Homo sapiens	193-196
21726816-2	2011	MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail.	Lysine	108-114	male-specific lethal 2	Drosophila melanogaster	0-4
21597337-10	2011	Histone H3 acetylation and histone H3 lysine 27 trimethylation on MSTN promoter were increased, while histone H3 lysine 9 monomethylation was decreased in LP pigs.	Lysine	38-44	myostatin	Sus scrofa	66-70
28663172-6	2017	Recombinant METTL21B was shown in vitro to catalyze methylation on lysine 165 in eEF1A1 and eEF1A2, confirming it as the methyltransferase responsible for this methylation site.	Lysine	67-73	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	92-98
7683664-6	1993	When mixtures of plasmin and STAR were adsorbed to lysine-Sepharose, STAR adsorbed quantitatively (96 +/- 1%) to the gel, whereas it was nearly quantitatively recovered in the unbound fraction (92 +/- 4%) after addition of alpha 2-antiplasmin to the mixture.	Lysine	51-57	steroidogenic acute regulatory protein	Homo sapiens	29-33
7683664-6	1993	When mixtures of plasmin and STAR were adsorbed to lysine-Sepharose, STAR adsorbed quantitatively (96 +/- 1%) to the gel, whereas it was nearly quantitatively recovered in the unbound fraction (92 +/- 4%) after addition of alpha 2-antiplasmin to the mixture.	Lysine	51-57	steroidogenic acute regulatory protein	Homo sapiens	69-73
8324021-7	1993	The strains with positive signal were selected to perform colony hybridization and Southern blot with oligonucleotide probes for TEM-1 (Gln 37) and TEM-2 (Lys 37).	Lysine	155-158	RASD family member 2	Homo sapiens	148-153
27573876-2	2017	Here, we found that a history of alcohol dependence persistently decreased the expression of Prdm2, a histone methyltransferase that monomethylates histone 3 at the lysine 9 residue (H3K9me1), in the rat dorsomedial prefrontal cortex (dmPFC).	Lysine	165-171	PR/SET domain 2	Rattus norvegicus	93-98
21388379-6	2011	Here, we demonstrate that NtUBP12 and AtUBP12 are bona fide deubiquitinating enzymes capable of cleaving lysine-48-linked ubiquitin chains.	Lysine	105-111	ubiquitin-specific protease 12	Arabidopsis thaliana	38-45
21750686-6	2011	This provided evidence for its NAT activity targeting Met-Lys- and other Met-starting protein N-termini, and the enzyme was termed Naa60p and its activity NatF.	Lysine	58-61	N-alpha-acetyltransferase 60, NatF catalytic subunit	Homo sapiens	131-137
21573619-1	1993	Y-79 retinoblastoma cells grown on a poly-D-lysine-coated substratum can assume a photoreceptor-like morphology and they express the retina-specific interphotoreceptor-retinoid-binding protein (IRBP) mRNA in abundance.	Lysine	44-50	retinol binding protein 3	Homo sapiens	194-198
21750686-6	2011	This provided evidence for its NAT activity targeting Met-Lys- and other Met-starting protein N-termini, and the enzyme was termed Naa60p and its activity NatF.	Lysine	58-61	zinc finger protein 644	Homo sapiens	155-159
21521686-4	2011	The longer mBMAL1 fragment (BMAL490) includes Lys-537, which is rhythmically acetylated by mCLOCK in vivo.	Lysine	46-49	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	11-17
21521686-9	2011	We propose that Lys-537(mBMAL1) acetylation enhances mCRY1 binding by affecting electrostatic interactions predominantly with the mCRY1 tail.	Lysine	16-19	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	24-30
29183317-4	2017	RESULTS: In the hippocampus, Smad4 is SUMOylated by the E3 ligase PIAS1 at Lys-113 and Lys-159.	Lysine	75-78	SMAD family member 4	Rattus norvegicus	29-34
29183317-4	2017	RESULTS: In the hippocampus, Smad4 is SUMOylated by the E3 ligase PIAS1 at Lys-113 and Lys-159.	Lysine	87-90	SMAD family member 4	Rattus norvegicus	29-34
8461292-7	1993	Within the monoacetylated series, acetylation of the amino terminal of Cys-1, as compared to the epsilon-amino group of either Lys-2 or Lys-24, leads to the greatest shift in potency.	Lysine	127-130	cystin 1	Rattus norvegicus	71-76
29234344-2	2017	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, has been proposed as a plant specific subunit of PRC1 that could bind the trimethylated lysine 27 of histone H3 (H3K27me3), which is established by PRC2 and is required for a functional plant PcG system.	Lysine	176-182	like heterochromatin protein (LHP1)	Arabidopsis thaliana	16-46
29234344-2	2017	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, has been proposed as a plant specific subunit of PRC1 that could bind the trimethylated lysine 27 of histone H3 (H3K27me3), which is established by PRC2 and is required for a functional plant PcG system.	Lysine	176-182	like heterochromatin protein (LHP1)	Arabidopsis thaliana	48-52
29234344-2	2017	In Arabidopsis, LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), also known as TERMINAL FLOWER 2, has been proposed as a plant specific subunit of PRC1 that could bind the trimethylated lysine 27 of histone H3 (H3K27me3), which is established by PRC2 and is required for a functional plant PcG system.	Lysine	176-182	like heterochromatin protein (LHP1)	Arabidopsis thaliana	69-86
29234344-3	2017	LHP1 not only interacts with PRC1 to catalyze monoubiquitination at lysine 119 of histone H2A but also functions with PRC2 to establish H3K27me3.	Lysine	68-74	like heterochromatin protein (LHP1)	Arabidopsis thaliana	0-4
21543646-4	2011	The cytoplasmic domain of CD3 zeta also contains several clusters of arginine and lysine residues.	Lysine	82-88	CD247 molecule	Homo sapiens	26-34
8461292-7	1993	Within the monoacetylated series, acetylation of the amino terminal of Cys-1, as compared to the epsilon-amino group of either Lys-2 or Lys-24, leads to the greatest shift in potency.	Lysine	136-139	cystin 1	Rattus norvegicus	71-76
21498512-6	2011	CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that readily interact with iso[4]LGE(2) in vitro.	Lysine	29-32	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
8437136-1	1993	The putative D2 dopamine receptor agonist quinpirole (LY 171,555) has been extensively used in a variety of in vivo and in vitro studies of D2 receptor-mediated effects and may have even higher affinity for the recently described D3 dopamine receptor.	Lysine	54-56	dopamine receptor D2	Rattus norvegicus	13-33
21498512-6	2011	CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that readily interact with iso[4]LGE(2) in vitro.	Lysine	43-46	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
21498512-6	2011	CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that readily interact with iso[4]LGE(2) in vitro.	Lysine	43-46	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
21498512-6	2011	CYP27A1 exhibited only three Lys residues, Lys(134), Lys(358), and Lys(476), that readily interact with iso[4]LGE(2) in vitro.	Lysine	43-46	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-7
28912266-5	2017	ER stress leads to de novo biosynthesis of non-trimethylated GRP78, whereas homeostatic, METTL21A-dependent lysine 585-trimethylated GRP78 is reduced.	Lysine	108-114	methyltransferase 21A, HSPA lysine	Homo sapiens	89-97
8443603-4	1993	The synthetic peptide Lys-Pro-Ile-Glu-Phe*Nph-Arg-Leu has proven to be an excellent chromogenic substrate for cathepsin D yielding a value of kcat/Km = 0.92 x 10(-6) s-1 M-1 for enzyme isolated from human placenta.	Lysine	22-25	cathepsin D	Homo sapiens	110-121
29021135-5	2017	Mechanistic investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate PIK3CA transcription, thereby enhancing PI3K/AKT signaling and tumorigenesis.	Lysine	62-68	lysine acetyltransferase 6A	Homo sapiens	45-50
21463657-5	2011	Overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity.	Lysine	114-120	tripartite motif containing 29	Homo sapiens	18-24
21498644-5	2011	Furthermore, Paf1 complex-dependent histone modifications are enriched at the ARG1 locus in repressing conditions, and histone H3 lysine 4 methylation contributes to ARG1 repression.	Lysine	130-136	argininosuccinate synthase	Saccharomyces cerevisiae S288C	166-170
8397057-8	1993	The results with alpha-MSH(8-13) are consistent with previous findings of lesser antihost response activity of alpha-MSH fragments that contain the COOH-terminal tripeptide Lys-Pro-Val.	Lysine	173-176	pro-opiomelanocortin-alpha	Mus musculus	111-120
21498644-6	2011	Consistent with previous reports, histone H2B monoubiquitylation, the mark upstream of histone H3 lysine 4 methylation, is also important for ARG1 repression.	Lysine	98-104	argininosuccinate synthase	Saccharomyces cerevisiae S288C	142-146
21849816-2	2011	AtAGP17, 18 and 19 are homologous genes encoding three classical lysine-rich AGPs in Arabidopsis.	Lysine	65-71	arabinogalactan protein 17	Arabidopsis thaliana	0-7
29264886-7	2017	Likewise, the frequency of the XPD Lys+ genotype was significantly increased in the patients as compared to the controls, and carriers of the Lys+ genotype had an increased risk for OCD (p = 0.027).	Lysine	35-38	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	31-34
29264886-10	2017	XPD Lys/Lys genotype frequency and XPD Gln+ frequency are also significantly associated even after Bonferroni correction (p &lt; 0.008).	Lysine	4-7	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-3
29264886-10	2017	XPD Lys/Lys genotype frequency and XPD Gln+ frequency are also significantly associated even after Bonferroni correction (p &lt; 0.008).	Lysine	8-11	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-3
29264886-11	2017	CONCLUSIONS: The findings suggest that XPD Lys/Lys might play a facilitating role in the development of OCD.	Lysine	43-46	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	39-42
29264886-11	2017	CONCLUSIONS: The findings suggest that XPD Lys/Lys might play a facilitating role in the development of OCD.	Lysine	47-50	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	39-42
21168982-8	2011	Among the substitutions, the Env amino acid position at 407 of TM2PI was substituted to lysine which has been known to be responsible for the FIV tropism for Crandell feline kidney cells.	Lysine	88-94	envelope polyprotein;hypothetical protein	Feline immunodeficiency virus	29-32
8423225-2	1993	Rhesus lipoprotein(a) (Lp[a]) binds less efficiently than human Lp(a) to lysine-Sepharose and to cultured U937 cells.	Lysine	73-79	lipoprotein(a)	Homo sapiens	7-21
21322057-6	2011	The methylation of histone H3 at lysine 4 residue (H3K4me2) associated with the STAT (signal transducer and activator of transcription)-binding site of the GFAP promoter was significantly decreased in the gray matter of the FGF-2 null mouse, suggesting a role for FGF-2 in the epigenetic regulation of astrocyte differentiation in vivo.	Lysine	33-39	glial fibrillary acidic protein	Mus musculus	156-160
21489093-0	2011	Expression analyses of AtAGP17 and AtAGP19, two lysine-rich arabinogalactan proteins, in Arabidopsis.	Lysine	48-54	arabinogalactan protein 17	Arabidopsis thaliana	23-30
21489093-4	2011	Peptide-specific antibodies were raised against the Lys-rich regions of AtAGP17 and AtAGP19 and used to study the organ-specific expression patterns of these two AGPs.	Lysine	52-55	arabinogalactan protein 17	Arabidopsis thaliana	72-79
28938454-7	2017	Our results demonstrate that 11beta-HSD2 is SUMOylated at lysine 266.	Lysine	58-64	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	29-40
8423225-2	1993	Rhesus lipoprotein(a) (Lp[a]) binds less efficiently than human Lp(a) to lysine-Sepharose and to cultured U937 cells.	Lysine	73-79	lipoprotein(a)	Homo sapiens	64-68
21637793-2	2011	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown, in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	Lysine	252-258	HOX transcript antisense RNA	Homo sapiens	0-6
29029378-8	2017	In conclusion, Gpn1-inhibitable, nuclear polyubiquitination on lysine 216 regulates the half-life of Gpn3 by tagging it for proteasomal degradation.	Lysine	63-69	GPN-loop GTPase 1	Homo sapiens	15-19
1479581-9	1992	In order to effect interaction with the S1"-S3" subsites of HLE, the leaving group side of cleaved peptides, spacers based upon Gly-Gly, and those linked via the N epsilon of L-lysine were utilized.	Lysine	175-183	elastase, neutrophil expressed	Homo sapiens	60-63
28757400-7	2017	On the other hand, repression of EC-SOD expression was associated with deacetylation of lysine 9 on histone H3 and lysines 5, 8, 12 and 16 on histone H4 located at the gene promoter.	Lysine	88-94	superoxide dismutase 3, extracellular	Mus musculus	33-39
28757400-7	2017	On the other hand, repression of EC-SOD expression was associated with deacetylation of lysine 9 on histone H3 and lysines 5, 8, 12 and 16 on histone H4 located at the gene promoter.	Lysine	115-122	superoxide dismutase 3, extracellular	Mus musculus	33-39
21333652-2	2011	Using fusion proteins in vitro, in combination with site-directed mutagenesis and surface plasmon resonance measurements, we previously showed that the binding site on sAnk1 for obscurin consists, in part, of six lysine and arginine residues.	Lysine	213-219	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Homo sapiens	178-186
21333652-3	2011	Here we show that four charged residues in the high-affinity binding site on obscurin for sAnk1 (between residues 6316 and 6345), consisting of three glutamates and a lysine, are necessary, but not sufficient, for this site on obscurin to bind to sAnk1 with high affinity.	Lysine	167-173	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Homo sapiens	77-85
21333652-6	2011	The models, based on a combination of Brownian and molecular dynamics simulations, predict that the binding site on sAnk1 for obscurin is organized as two ankyrin-like repeats, with the last alpha-helical segment oriented at an angle to nearby helices, allowing lysine 6338 of obscurin to form an ionic interaction with aspartate 111 of sAnk1.	Lysine	262-268	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Homo sapiens	126-134
1445886-6	1992	Coumarin 7-hydroxylation activity is greatly stimulated by cytochrome b5 only when Phe is at position 209, while cytochrome b5 stimulates testosterone hydroxylation activity of P450coh in which Phe, Asn, Ser or Lys substitutes residue 209.	Lysine	211-214	cytochrome b5 type A (microsomal)	Mus musculus	59-72
21391620-7	2011	The two disulfide-linked conjugates, mAb-SPP-[(3)H]DM1 and mAb-SPDB-[(3)H]DM4, were also found to be catabolized to the analogous lysine-linked maytansinoid metabolites.	Lysine	130-136	immunoglobulin heavy diversity 1-7	Homo sapiens	51-54
29094203-3	2017	In the current study, we performed ENU (ethylnitrosourea) mutagenesis that resulted in substituting a conserved lysine with a serine (p. L247S) in the DNA-binding domain of the MITF gene to generate a novel miniature pig model of WS2A.	Lysine	112-118	melanocyte inducing transcription factor	Homo sapiens	177-181
1445886-6	1992	Coumarin 7-hydroxylation activity is greatly stimulated by cytochrome b5 only when Phe is at position 209, while cytochrome b5 stimulates testosterone hydroxylation activity of P450coh in which Phe, Asn, Ser or Lys substitutes residue 209.	Lysine	211-214	cytochrome b5 type A (microsomal)	Mus musculus	113-126
21395319-0	2011	Incorporation of ortho-carbaboranyl-Nepsilon-modified L-lysine into neuropeptide Y receptor Y1- and Y2-selective analogues.	Lysine	54-62	neuropeptide Y receptor Y1	Homo sapiens	68-102
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	147-150	pro-opiomelanocortin-alpha	Mus musculus	72-76
21310926-1	2011	The histone H3 lysine 36 dimethyl-specific demethylase KDM2b/JHDM1b, which is highly expressed in various human leukemias, was previously found to be important in regulating cell proliferation and cellular senescence.	Lysine	15-21	lysine demethylase 2B	Homo sapiens	55-60
21310926-1	2011	The histone H3 lysine 36 dimethyl-specific demethylase KDM2b/JHDM1b, which is highly expressed in various human leukemias, was previously found to be important in regulating cell proliferation and cellular senescence.	Lysine	15-21	lysine demethylase 2B	Homo sapiens	61-67
21310926-6	2011	The functions of Kdm2b/Jhdm1b are mediated by its silencing of p15(Ink4b) expression through active demethylation of histone H3 lysine 36 dimethyl.	Lysine	128-134	lysine demethylase 2B	Homo sapiens	17-22
21310926-6	2011	The functions of Kdm2b/Jhdm1b are mediated by its silencing of p15(Ink4b) expression through active demethylation of histone H3 lysine 36 dimethyl.	Lysine	128-134	lysine demethylase 2B	Homo sapiens	23-29
29382003-0	2017	Hemoglobin Hornchurch [beta43 (CD2) Glu &gt; Lys; HBB: c.130G &gt; A] in a Chinese boy complicated with thrombocytopenia: A case report and literature review.	Lysine	45-48	CD2 molecule	Homo sapiens	31-34
29113254-11	2017	FHL1 was synergistically silenced by DNA methylation and histone modification, and 3-deanzaneplanocin A (DZNep), an inhibitor of EZH2, which is a histone methyltransferase of the polycomb repressive complex 2, which catalyzes histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	237-243	four and a half LIM domains 1	Homo sapiens	0-4
29042477-0	2017	KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis.	Lysine	43-49	neurogenin 2 L homeolog	Xenopus laevis	89-96
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	147-150	pro-opiomelanocortin-alpha	Mus musculus	98-102
21300781-1	2011	In budding yeast and humans, cohesion establishment during S phase requires the acetyltransferase Eco1/Esco1-2, which acetylates the cohesin subunit Smc3 on two conserved lysine residues.	Lysine	171-177	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	98-102
21300781-1	2011	In budding yeast and humans, cohesion establishment during S phase requires the acetyltransferase Eco1/Esco1-2, which acetylates the cohesin subunit Smc3 on two conserved lysine residues.	Lysine	171-177	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	103-110
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	151-154	pro-opiomelanocortin-alpha	Mus musculus	72-76
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	151-154	pro-opiomelanocortin-alpha	Mus musculus	98-102
1390778-2	1992	We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn--&gt;Lys15, His--&gt;Arg209, Phe--&gt;Val382, Lys--&gt;Glu460, and Asn--&gt;Ser462) and studied the effects of these mutations upon posttranslational processing, insulin binding, and tyrosine autophosphorylation.	Lysine	115-118	insulin receptor	Homo sapiens	88-104
21552333-8	2011	Acetylation levels increased significantly in the hda6 mutant at all of the lysine residues in the H3 and H4 N-tails, except H4K16.	Lysine	76-82	histone deacetylase 6	Arabidopsis thaliana	50-54
29212211-1	2017	SETD7 is a methyltransferase that specifically catalyzes the monomethylation of lysine 4 on histone H3.	Lysine	80-86	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-5
1388166-8	1992	TFPI contains the sequence Pro-Phe-Lys, 9 residues N-terminal to the glycosylation site at position 228; this tripeptide may act as the recognition sequence for the GalNAc-transferase.	Lysine	35-38	tissue factor pathway inhibitor	Homo sapiens	0-4
28899943-5	2017	Results presented here indicate that Isw1 is not only ubiquitylated but also strongly SUMOylated on multiple lysine residues by the redundant Siz1/Siz2 SUMO E3 ligases.	Lysine	109-115	SUMO ligase SIZ1	Saccharomyces cerevisiae S288C	142-146
21483786-4	2011	In addition, the histone H3 lysine 27-specific demethylase JMJD3 induces ARF expression, thereby stabilizing p53 in mouse embryonic fibroblasts.	Lysine	28-34	transformation related protein 53, pseudogene	Mus musculus	109-112
21365783-3	2011	A novel peptide segment of beta2M ranging from residue 58 to residue 67 (Lys-Asp-Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr), which was capable of being fibrillated at neutral pH was isolated.	Lysine	73-76	beta-2-microglobulin	Homo sapiens	27-33
1356154-1	1992	The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies of D2 receptor-mediated effects.	Lysine	54-56	dopamine receptor D2	Rattus norvegicus	13-33
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	VEFS-Box of polycomb protein	Arabidopsis thaliana	68-83
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	VEFS-Box of polycomb protein	Arabidopsis thaliana	85-89
28771755-8	2017	Furthermore, PKL affects the level of trimethylation of histone H3 Lys 27 associated with INDOLE-3-ACETIC ACID INDUCIBLE 19 (IAA19) and IAA29 and regulates their expression.	Lysine	67-70	indole-3-acetic acid inducible 19	Arabidopsis thaliana	90-123
28771755-8	2017	Furthermore, PKL affects the level of trimethylation of histone H3 Lys 27 associated with INDOLE-3-ACETIC ACID INDUCIBLE 19 (IAA19) and IAA29 and regulates their expression.	Lysine	67-70	indole-3-acetic acid inducible 19	Arabidopsis thaliana	125-130
21402527-2	2011	During vernalization, the Polycomb Repressive Complex 2, containing VERNALIZATION 2 (VRN2), CLF/SWN, FIE, and MSI1, can trimethylate the lysine 27 of histone H3 in the chromtin loci of FLOWER LOCUS C (FLC), the main flowering repressor in Arabidopsis.	Lysine	137-143	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	110-114
28963509-4	2017	Of sequence-related properties studied, relative lysine to arginine content was found to be higher in CH1 and CL than in variable domains.	Lysine	49-55	SUN domain containing ossification factor	Homo sapiens	102-105
1380826-6	1992	The lysine-specific reagent PLP was found to be a noncompetitive inhibitor with respect to both primer-template [poly(rA).oligo(dT)] and dTTP.	Lysine	4-10	pyridoxal phosphatase	Homo sapiens	28-31
28876923-3	2017	A lysine derivative of Sph, SphK, was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of class B G protein-coupled receptors (GPCRs) in mammalian cells with the incorporation efficiency dependent on the location.	Lysine	2-8	sphingosine kinase 1	Homo sapiens	28-32
21183685-2	2011	Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(428) promotes trafficking of activated receptors to the lysosomes for degradation.	Lysine	75-78	erythropoietin receptor	Homo sapiens	41-64
21183685-2	2011	Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(428) promotes trafficking of activated receptors to the lysosomes for degradation.	Lysine	75-78	erythropoietin receptor	Homo sapiens	66-70
28760828-5	2017	These findings uncover a novel acetylation-phosphorylation switch at Lys-321/Ser-324 that coordinately regulates tau polymerization and function.	Lysine	69-72	microtubule associated protein tau	Homo sapiens	113-116
1644824-5	1992	Evidence that furin may require a P4 Arg in fluorogenic peptide substrates suggested that this enzyme might cleave the protective antigen (PA) component of anthrax toxin at the sequence -Arg-Lys-Lys-Arg-.	Lysine	191-194	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
1412165-0	1992	Lysine-binding heterogeneity of Lp(a): consequences for fibrin binding and inhibition of plasminogen activation.	Lysine	0-6	lipoprotein(a)	Homo sapiens	32-37
28798096-2	2017	S100P protein possesses a C-terminal lysine residue.	Lysine	37-43	S100 calcium binding protein P	Homo sapiens	0-5
28798096-3	2017	Using a multiwell in vitro assay, S100P is now shown for the first time to exhibit a strong, C-terminal lysine-dependent activation of tissue plasminogen activator (tPA), but not of urokinase-catalysed plasminogen activation.	Lysine	104-110	S100 calcium binding protein P	Homo sapiens	34-39
28798096-7	2017	S100P shows C-terminal lysine-dependent enhancement of cell invasion.	Lysine	23-29	S100 calcium binding protein P	Homo sapiens	0-5
28798096-8	2017	An S100P antibody, when added to the culture medium, reduced the rate of invasion of wild-type S100P-expressing cells, but not of cells expressing mutant S100P proteins lacking the C-terminal lysine, suggesting that S100P functions outside the cell.	Lysine	192-198	S100 calcium binding protein P	Homo sapiens	3-8
21139082-5	2011	The chromatin status at the Aiolos promoter in CLL is defined by the demethylation of DNA and an enrichment of euchromatin associated histone markers, such as the dimethylation of the lysine 4 on histone H3.	Lysine	184-190	IKAROS family zinc finger 3	Homo sapiens	28-34
21269355-6	2011	Because it has been observed that higher oxidative capacity is associated with higher IMF content, we hypothesized that dietary low lysine would promote IMF accumulation.	Lysine	132-138	IMF	Sus scrofa	86-89
21269355-6	2011	Because it has been observed that higher oxidative capacity is associated with higher IMF content, we hypothesized that dietary low lysine would promote IMF accumulation.	Lysine	132-138	IMF	Sus scrofa	153-156
21269355-7	2011	Further, higher mRNA abundance of peroxisome proliferator-activated receptor gamma, a master regulator of adipogenesis, in both muscles induced by dietary low lysine, supported this hypothesis.	Lysine	159-165	peroxisome proliferator activated receptor gamma	Sus scrofa	34-82
21269355-8	2011	Indeed, IMF content of L. dorsi muscle of finishing pigs given a low lysine diet for 2 months until reaching the market weight was twice that of pigs given a control diet.	Lysine	69-75	IMF	Sus scrofa	8-11
1412165-5	1992	We prepared Lp(a) from plasma by sequential ultracentrifugation followed by lysine-sepharose affinity chromatography.	Lysine	76-82	lipoprotein(a)	Homo sapiens	12-17
1412165-8	1992	Bound Lp(a) [Lp(a)lys+] was eluted with 0.2 M EACA.	Lysine	18-21	lipoprotein(a)	Homo sapiens	6-11
21115810-3	2011	We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes.	Lysine	136-139	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	92-97
1629222-1	1992	Human furin is a calcium-dependent serine endoprotease that can efficiently cleave many precursor proteins on the carboxyl side of the consensus cleavage sequence, -Arg-X-Lys/Arg-Arg-, both in vivo and in vitro.	Lysine	171-174	furin, paired basic amino acid cleaving enzyme	Homo sapiens	6-11
21149574-2	2011	Lack of HBO1 led to a more than 90% reduction of histone 3 lysine 14 (H3K14) acetylation, whereas no reduction of acetylation was detected at other histone residues.	Lysine	59-65	lysine acetyltransferase 7	Homo sapiens	8-12
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 18	Homo sapiens	23-26
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 18	Homo sapiens	115-118
28798096-10	2017	It is proposed that activation of tPA via the C-terminal lysine of S100P contributes to the enhancement of cell invasion by S100P and thus potentially to its metastasis-promoting activity.	Lysine	57-63	S100 calcium binding protein P	Homo sapiens	67-72
28798096-10	2017	It is proposed that activation of tPA via the C-terminal lysine of S100P contributes to the enhancement of cell invasion by S100P and thus potentially to its metastasis-promoting activity.	Lysine	57-63	S100 calcium binding protein P	Homo sapiens	124-129
28900200-6	2017	Furthermore, in ESCs, DNMT3b interacts with histone H3 tri-methylated at lysine 36 (H3K36me3), resulting in hyper-methylation at CpHs upon actively transcribed genes, including those involved in embryo development.	Lysine	73-79	DNA methyltransferase 3 beta	Homo sapiens	22-28
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 18	Homo sapiens	23-26
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 18	Homo sapiens	23-26
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Lysine	291-294	furin, paired basic amino acid cleaving enzyme	Homo sapiens	44-49
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Lysine	291-294	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
28819560-2	2017	With computational prediction algorithms and structure-based drug design, we identified peptides containing the Gly-Lys-Gly-Glu-Gly-Glu-Gly-Lys-Gly sequence (peptide H1), which strongly interacts with uPAR.	Lysine	116-119	plasminogen activator, urokinase receptor	Homo sapiens	201-205
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Lysine	291-294	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
20923787-0	2011	Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I. Glutaric aciduria type I, an inherited deficiency of glutaryl-coenzyme A dehydrogenase localized in the final common catabolic pathway of L-lysine, L-hydroxylysine and L-tryptophan, leads to accumulation of neurotoxic glutaric and 3-hydroxyglutaric acid, as well as non-toxic glutarylcarnitine.	Lysine	35-43	glutaryl-Coenzyme A dehydrogenase	Mus musculus	155-188
20923787-0	2011	Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I. Glutaric aciduria type I, an inherited deficiency of glutaryl-coenzyme A dehydrogenase localized in the final common catabolic pathway of L-lysine, L-hydroxylysine and L-tryptophan, leads to accumulation of neurotoxic glutaric and 3-hydroxyglutaric acid, as well as non-toxic glutarylcarnitine.	Lysine	240-248	glutaryl-Coenzyme A dehydrogenase	Mus musculus	155-188
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Lysine	291-294	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
1628654-1	1992	Site-directed mutagenesis has been used to produce mutant forms of yeast phosphoglycerate kinase in which the conserved active-site residue, Arg21, has been replaced by a methionine or a lysine.	Lysine	187-193	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	73-96
22272142-1	2011	Histone deacetylase 8 (HDAC8) is an enzyme involved in deacetylating the amino groups of terminal lysine residues, thereby repressing the transcription of various genes including tumor suppressor gene.	Lysine	98-104	histone deacetylase 8	Homo sapiens	0-21
22272142-1	2011	Histone deacetylase 8 (HDAC8) is an enzyme involved in deacetylating the amino groups of terminal lysine residues, thereby repressing the transcription of various genes including tumor suppressor gene.	Lysine	98-104	histone deacetylase 8	Homo sapiens	23-28
28666963-9	2017	Overall, our results suggest that the replacement of a negatively charged residue with a positively charged lysine at position 283 in Kv1.1 causes a drop of potassium current that likely accounts for EA-1 symptoms in the heterozygous carrier.	Lysine	108-114	potassium voltage-gated channel subfamily A member 1	Homo sapiens	134-139
28666963-9	2017	Overall, our results suggest that the replacement of a negatively charged residue with a positively charged lysine at position 283 in Kv1.1 causes a drop of potassium current that likely accounts for EA-1 symptoms in the heterozygous carrier.	Lysine	108-114	potassium voltage-gated channel subfamily A member 1	Homo sapiens	200-204
28848693-4	2017	Mass spectrometry of a variant of Deg1-Sec62 revealed that the protein is acetylated at the N-terminal methionine and two internal lysine residues.	Lysine	131-137	pseudouridine synthase DEG1	Saccharomyces cerevisiae S288C	34-38
1607649-3	1992	We previously reported that alterations in the H chain V regions can affect the binding of first component of C (C1q) and a major breakdown product of the third C component (C3b) when otherwise identical antibodies were bound to immobilized (Tyr, Glu)-Ala-Lys.	Lysine	256-259	endogenous retrovirus group K member 3	Homo sapiens	174-177
28655759-0	2017	RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.	Lysine	112-118	RNA binding motif protein 25	Homo sapiens	0-5
28655759-8	2017	Previously, we identified an RBM25 species that is mono-methylated at lysine 77 (RBM25K77me1), and here we used quantitative mass spectrometry to show that RBM25K77me1 is abundant in multiple human cell lines.	Lysine	70-76	RNA binding motif protein 25	Homo sapiens	29-34
21427723-5	2011	Mass spectrometry analysis identified specific lysine residues, including lysine 280 (K280) within the microtubule-binding motif as the major sites of tau acetylation.	Lysine	47-53	microtubule associated protein tau	Homo sapiens	151-154
21427723-5	2011	Mass spectrometry analysis identified specific lysine residues, including lysine 280 (K280) within the microtubule-binding motif as the major sites of tau acetylation.	Lysine	74-80	microtubule associated protein tau	Homo sapiens	151-154
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	46-49	RNA binding motif protein 25	Homo sapiens	31-36
1597470-2	1992	The cDNA for the developmentally regulated, neurite outgrowth-promoting protein HB-GAM (heparin-binding growth-associated molecule) was recently cloned and shown to encode a novel lysine-rich sequence that is homologous with retinoic acid-induced sequences suggested to function in cell differentiation (Merenmies, J., and Rauvala, H. (1990) J. Biol.	Lysine	180-186	pleiotrophin	Rattus norvegicus	80-86
28655759-9	2017	We also identified a region of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing factor 2 (SRSF2), a crucial protein in exon definition, but only when Lys-77 is unmethylated.	Lysine	191-194	RNA binding motif protein 25	Homo sapiens	31-36
28655759-10	2017	Together, our findings uncover a pivotal role for RBM25 as an essential regulator of alternative splicing and reveal a new potential mechanism for regulation of pre-mRNA splicing by lysine methylation of a splicing factor.	Lysine	182-188	RNA binding motif protein 25	Homo sapiens	50-55
28673962-7	2017	Furthermore, our observed effects of in vitro acetylation on the canonical activities of IDH, MDH and LDH appeared to contrast with previous findings wherein acetyl-mimetic lysine mutations resulted in the inhibition of these enzymes.	Lysine	173-179	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	89-92
22132161-6	2011	Using several chromogenic substrates and serine proteinase inhibitors, we demonstrate that ISP1 exhibits trypsin-like substrate specificity, having a preference for lysine over arginine at the P1 position.	Lysine	165-171	protease, serine 28	Mus musculus	91-95
22073215-6	2011	Interestingly, Tat binds to promoters of genes that, in Jurkat cells, are bound by the ETS1 transcription factor, the CBP histone acetyltransferase and/or are enriched for histone H3 lysine 4 tri-methylation (H3K4me3) and H3K27me3.	Lysine	183-189	ETS proto-oncogene 1, transcription factor	Homo sapiens	87-91
21858169-5	2011	Lysine acetylation of Foxo4 is required for Foxo4 binding and transcription of Bcl2l11 in podocytes treated with AGE-BSA.	Lysine	0-6	forkhead box O4	Homo sapiens	22-27
1597470-2	1992	The cDNA for the developmentally regulated, neurite outgrowth-promoting protein HB-GAM (heparin-binding growth-associated molecule) was recently cloned and shown to encode a novel lysine-rich sequence that is homologous with retinoic acid-induced sequences suggested to function in cell differentiation (Merenmies, J., and Rauvala, H. (1990) J. Biol.	Lysine	180-186	pleiotrophin	Rattus norvegicus	88-130
21858169-5	2011	Lysine acetylation of Foxo4 is required for Foxo4 binding and transcription of Bcl2l11 in podocytes treated with AGE-BSA.	Lysine	0-6	forkhead box O4	Homo sapiens	44-49
21858169-5	2011	Lysine acetylation of Foxo4 is required for Foxo4 binding and transcription of Bcl2l11 in podocytes treated with AGE-BSA.	Lysine	0-6	BCL2 like 11	Homo sapiens	79-86
1532491-4	1992	The amino acid analogue 6-aminohexanoic acid (AHA), which is known to bind to lysine-binding sites in plasmin, suppressed the stimulatory effect of oleic acid in a concentration-dependent manner; at 0.3 mM-AHA, about 70% of the oleic acid-dependent enhancement of plasmin activity was abolished.	Lysine	78-84	plasminogen	Homo sapiens	102-109
29228645-4	2017	Sumoylation of Snail1 lysine residue 234 confers its transcriptional activity, inducing the expression of classical EMT genes, as well as TGFbeta receptor I (TbetaRI) and the transcriptional repressor Hes1.	Lysine	22-28	transforming growth factor beta receptor 1	Homo sapiens	138-156
29228645-4	2017	Sumoylation of Snail1 lysine residue 234 confers its transcriptional activity, inducing the expression of classical EMT genes, as well as TGFbeta receptor I (TbetaRI) and the transcriptional repressor Hes1.	Lysine	22-28	transforming growth factor beta receptor 1	Homo sapiens	158-165
1330132-0	1992	Purification of cytochrome c oxidase by lysine-affinity chromatography.	Lysine	40-46	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	16-36
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	21-27	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	116-120
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	35-41	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	116-120
21041298-0	2010	Regulation of angiogenesis by histone chaperone HIRA-mediated incorporation of lysine 56-acetylated histone H3.3 at chromatin domains of endothelial genes.	Lysine	79-85	histone cell cycle regulator	Homo sapiens	48-52
21041298-4	2010	Our molecular analyses revealed that, in response to angiogenic signals, HIRA is induced in endothelial cells and mediates incorporation of lysine 56 acetylated histone H3.3 (H3acK56) at the chromatin domain of Vegfr1.	Lysine	140-146	histone cell cycle regulator	Homo sapiens	73-77
21172655-0	2010	Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.	Lysine	57-63	sirtuin 3	Mus musculus	0-5
1330132-1	1992	A method for the purification of cytochrome c oxidase that is based on the affinity of this enzyme for polycations such as poly-L-lysine is described.	Lysine	123-136	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	33-53
1330132-2	1992	When detergent extracts of bovine cardiac mitochondria were applied to either a poly-L-lysine-agarose or a lysine-Sepharose column at low ionic strength, cytochrome c oxidase was found to adhere tightly, whereas the bulk of the proteins were eluted by washing with the same buffer.	Lysine	87-93	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	154-174
1309773-7	1992	Isopeptidase T acts on polyUb-protein conjugates, but not on conjugates in which the formation of polyUb chains was prevented by the use of reductively methylated Ub or on abnormal polyUb chains formed with a mutant Ub that contains a Lys----Arg substitution at residue 48.	Lysine	235-238	ubiquitin specific peptidase 5	Homo sapiens	0-14
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	lysine methyltransferase 2A	Homo sapiens	110-113
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	MLLT1 super elongation complex subunit	Homo sapiens	145-148
21159644-3	2010	Dot1, the only known histone H3 lysine 79 (H3K79) methyltransferase, has been shown to interact with multiple MLL fusion partners including AF9, ENL, AF10, and AF17.	Lysine	32-38	MLLT10 histone lysine methyltransferase DOT1L cofactor	Homo sapiens	150-154
28593724-2	2017	We report an approach inspired by the posttranslational acetylation/deacetylation of lysine residues, in which a protein encoded by a gene with an in-frame nonsense codon at an essential lysine can be expressed in its native state only upon genetic incorporation of N-epsilon-acetyl-l-Lys (AcK), and subsequent enzymatic deacetylation in the host cell.	Lysine	85-91	tyrosine kinase non receptor 2	Homo sapiens	290-293
28593724-2	2017	We report an approach inspired by the posttranslational acetylation/deacetylation of lysine residues, in which a protein encoded by a gene with an in-frame nonsense codon at an essential lysine can be expressed in its native state only upon genetic incorporation of N-epsilon-acetyl-l-Lys (AcK), and subsequent enzymatic deacetylation in the host cell.	Lysine	187-193	tyrosine kinase non receptor 2	Homo sapiens	290-293
1735123-0	1992	Physical and biochemical characterization of the cloned LYS5 gene required for alpha-aminoadipate reductase activity in the lysine biosynthetic pathway of Saccharomyces cerevisiae.	Lysine	124-130	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	56-60
28453461-2	2017	SerpinE2 (a small ubiquitin-related modifier), like ubiquitin, conjugates SerpinE2 proteins onto lysine residues of target proteins.	Lysine	97-103	serpin family E member 2	Homo sapiens	0-8
28453461-2	2017	SerpinE2 (a small ubiquitin-related modifier), like ubiquitin, conjugates SerpinE2 proteins onto lysine residues of target proteins.	Lysine	97-103	serpin family E member 2	Homo sapiens	74-82
20836999-1	2010	BACKGROUND: Glutaric aciduria type 1 (GA1) is an inborn error in the metabolism of the amino acids tryptophan, lysine and hydroxylysine due to mutations in the GCDH gene coding for glutaryl-CoA dehydrogenase.	Lysine	111-117	glutaryl-CoA dehydrogenase	Homo sapiens	160-164
21156064-10	2010	LY-411,575 or DAPT also increased survival of primary neurons expressing endogenous full-length mutant huntingtin.	Lysine	0-2	huntingtin	Mus musculus	103-113
1735123-1	1992	The LYS5 and LYS2 genes of Saccharomyces cerevisiae are required for the synthesis of alpha-aminoadipate reductase in the lysine pathway.	Lysine	122-128	holo-[acyl-carrier-protein] synthase	Saccharomyces cerevisiae S288C	4-8
1735123-1	1992	The LYS5 and LYS2 genes of Saccharomyces cerevisiae are required for the synthesis of alpha-aminoadipate reductase in the lysine pathway.	Lysine	122-128	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	13-17
21212461-0	2010	Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.	Lysine	66-72	sirtuin 3	Mus musculus	26-31
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Lysine	6-12	Cbl proto-oncogene	Homo sapiens	176-179
21212461-3	2010	Here we report that the NAD+-dependent deacetylase SIRT3 deacetylates the regulatory component of the mPTP, cyclophilin D (CypD) on lysine 166, adjacent to the binding site of cyclosporine A, a CypD inhibitor.	Lysine	132-138	sirtuin 3	Mus musculus	51-56
1659529-0	1991	Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells.	Lysine	67-70	gonadotropin releasing hormone receptor	Rattus norvegicus	83-97
21109197-6	2010	Deacetylation of HMGCS2 lysines 310, 447, and 473 by incubation with wild-type SIRT3 or by mutation to arginine enhances its enzymatic activity.	Lysine	24-31	sirtuin 3	Mus musculus	79-84
28672915-7	2017	Furthermore, the majority of the histone H3 at lysine 9 sites that interacted with the Oct4 and Sox2 promoters were acetylated, suggesting that the transcription activities of the above two transcription factors significantly increased.	Lysine	47-53	POU class 5 homeobox 1	Homo sapiens	87-91
1794978-4	1991	In the reduced form, two Soret peaks were observable at 447 and 423 nm and their relative heights were dependent on pH, indicating the existence of two interconvertible states of ferrous Lys-mutated P450 which are in equilibrium.	Lysine	187-190	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	199-203
28476883-10	2017	We further demonstrated that HOTAIR regulates DR5 expression via the epigenetic regulator enhancer of zeste homolog 2 (EZH2) and that EZH2 controls histone H3 lysine 27 trimethylation on the DR5 gene.	Lysine	159-165	TNF receptor superfamily member 10b	Homo sapiens	191-194
20937772-3	2010	We found that Drosophila Ras1 is inefficiently prenylated as a consequence of a lysine in the A(1) position of its CAAX sequence such that a significant pool remains soluble in the cytosol.	Lysine	80-86	Ras oncogene at 85D	Drosophila melanogaster	25-29
28506985-2	2017	K (lysine) acetyltransferase 8 (KAT8), an important component of the X chromosome dosage compensation system in Drosophila, regulates gene activity by acetylating histone H4 preferentially at lysine 16.	Lysine	3-9	K(lysine) acetyltransferase 8	Mus musculus	32-36
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Lysine	54-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	189-193
21068368-1	2010	Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein.	Lysine	65-71	nei like DNA glycosylase 1	Homo sapiens	50-55
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Lysine	54-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	233-237
21124902-1	2010	Histone H3 lysine 4 (K4) methylation is a prevalent mark associated with transcription activation and is mainly catalyzed by the MLL/SET1 family histone methyltransferases.	Lysine	11-17	lysine methyltransferase 2A	Homo sapiens	129-132
28370702-3	2017	Through the process to search substrates for various methyltransferases using an in vitro methyltransferase assay, we found that a lysine methyltransferase, SET and MYND domain-containing 2 (SMYD2), could methylate lysine residues 1451, 1455, and 1610 in ALK protein.	Lysine	131-137	SET and MYND domain containing 2	Homo sapiens	157-189
28370702-3	2017	Through the process to search substrates for various methyltransferases using an in vitro methyltransferase assay, we found that a lysine methyltransferase, SET and MYND domain-containing 2 (SMYD2), could methylate lysine residues 1451, 1455, and 1610 in ALK protein.	Lysine	131-137	SET and MYND domain containing 2	Homo sapiens	191-196
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Lysine	177-180	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	189-193
20709017-0	2010	Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.	Lysine	154-160	dihydrodipicolinate synthase	Escherichia coli	55-83
20709017-0	2010	Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.	Lysine	154-160	dihydrodipicolinate synthase	Escherichia coli	85-90
1794978-6	1991	These findings suggest that epsilon-amino nitrogen of Lys-301, which was introduced by amino acid substitution, occupies the 6th coordination position with the heme iron of the Lys-mutated P450, because, owing to conformation of the P450 protein, the epsilon-amino group may be located at just the right position for coordination as the internal 6th ligand.	Lysine	177-180	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	233-237
20709017-7	2010	Furthermore, allosteric inhibition by (S)-lysine was abolished for DHDPS-L197D/Y107W, confirming the importance of the dimeric unit as the minimal functional assembly for efficient (S)-lysine binding.	Lysine	38-48	dihydrodipicolinate synthase	Escherichia coli	67-72
20709017-7	2010	Furthermore, allosteric inhibition by (S)-lysine was abolished for DHDPS-L197D/Y107W, confirming the importance of the dimeric unit as the minimal functional assembly for efficient (S)-lysine binding.	Lysine	181-191	dihydrodipicolinate synthase	Escherichia coli	67-72
1658624-4	1991	The expression of the uncleaved Met protein is due to defective posttranslational processing, since in this cell line (i) the proteolytic cleavage site Lys-303-Arg-Lys-Lys-Arg-Ser-308 is present in the precursor, (ii) p190NC is sensitive to mild trypsin digestion of the cell surface, generating alpha and beta chains of the correct size, and (iii) the 205-kDa insulin receptor precursor is not cleaved as well.	Lysine	164-167	insulin receptor	Homo sapiens	361-377
20829358-6	2010	Additionally, a BAF57 mutant, which contains no lysine residues, was found to retain its ability to be stabilized by interaction with BAF155, suggesting that in addition to the ubiquitin-dependent mechanism of BAF57 degradation, there exists a ubiquitin-independent mechanism that may involve the direct interaction of BAF57 with the proteasome.	Lysine	48-54	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	Homo sapiens	16-21
26706905-7	2017	The study suggests that ligand interaction with the residues Asp 48, Thr 44, Thr 77, Tyr 81, Trp29, Ile 143 of NRP-1 and Lys 653, Phe 765, Ser 763, Thr 699, Ile 683 of Eph might be critical for the inhibitory activity of these receptors.	Lysine	121-124	EPH receptor A1	Homo sapiens	168-171
28542143-0	2017	DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.	Lysine	141-147	E2F transcription factor 1	Homo sapiens	33-37
1658624-4	1991	The expression of the uncleaved Met protein is due to defective posttranslational processing, since in this cell line (i) the proteolytic cleavage site Lys-303-Arg-Lys-Lys-Arg-Ser-308 is present in the precursor, (ii) p190NC is sensitive to mild trypsin digestion of the cell surface, generating alpha and beta chains of the correct size, and (iii) the 205-kDa insulin receptor precursor is not cleaved as well.	Lysine	164-167	insulin receptor	Homo sapiens	361-377
28542143-2	2017	Here, we demonstrated that the E3-ubiquitin ligase cellular inhibitor of apoptosis 1 (cIAP1) increases E2F1 K63-poly-ubiquitination on the lysine residue 161/164 cluster, which is associated with the transcriptional factor stability and activity.	Lysine	139-145	E2F transcription factor 1	Homo sapiens	103-107
21062452-16	2010	CONCLUSIONS: Targeting MOF to reporter genes led to transcription enhancement and acetylation of histone H4 at lysine 16.	Lysine	111-117	males absent on the first	Drosophila melanogaster	23-26
28542143-3	2017	Mutation of these lysine residues completely abrogates the binding of E2F1 to CCNE, TP73 and APAF1 promoters, thus inhibiting transcriptional activation of these genes and E2F1-mediated cell proliferation control.	Lysine	18-24	E2F transcription factor 1	Homo sapiens	70-74
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Lysine	53-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
28542143-3	2017	Mutation of these lysine residues completely abrogates the binding of E2F1 to CCNE, TP73 and APAF1 promoters, thus inhibiting transcriptional activation of these genes and E2F1-mediated cell proliferation control.	Lysine	18-24	E2F transcription factor 1	Homo sapiens	172-176
28542143-4	2017	Importantly, E2F1 stabilization in response to etoposide-induced DNA damage or during the S phase of cell cycle, as revealed by cyclin A silencing, is associated with K63-poly-ubiquitinylation of E2F1 on lysine 161/164 residues and involves cIAP1.	Lysine	204-210	E2F transcription factor 1	Homo sapiens	13-17
28542143-4	2017	Importantly, E2F1 stabilization in response to etoposide-induced DNA damage or during the S phase of cell cycle, as revealed by cyclin A silencing, is associated with K63-poly-ubiquitinylation of E2F1 on lysine 161/164 residues and involves cIAP1.	Lysine	204-210	E2F transcription factor 1	Homo sapiens	196-200
20849112-3	2010	Lysine residues K325 and K373 on basic regions BR1 and BR3 of the DNA binding domain, respectively, are shown to be acetylated by PCAF.	Lysine	0-6	moladietz	Drosophila melanogaster	55-58
1776140-1	1991	When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK).	Lysine	120-126	plasminogen	Homo sapiens	41-48
21115916-3	2010	RESULTS: LY/Api synergistically induced apoptosis in leukaemia cells, especially CD34(+)CD38(-) leukaemia cells.	Lysine	9-11	CD38 molecule	Homo sapiens	88-92
28437098-3	2017	Our binding experiments with the (beta15-66)2 fragment, which corresponds to a pair of fibrin betaN-domains, and the VLDLR(1-8) fragment, consisting of eight CR domains of VLDLR, revealed that interaction between them strongly depends on ionic strength and chemical modification of all Lys or Arg residues in (beta15-66)2 results in abrogation of this interaction.	Lysine	286-289	very low density lipoprotein receptor	Homo sapiens	117-122
28437098-3	2017	Our binding experiments with the (beta15-66)2 fragment, which corresponds to a pair of fibrin betaN-domains, and the VLDLR(1-8) fragment, consisting of eight CR domains of VLDLR, revealed that interaction between them strongly depends on ionic strength and chemical modification of all Lys or Arg residues in (beta15-66)2 results in abrogation of this interaction.	Lysine	286-289	very low density lipoprotein receptor	Homo sapiens	172-177
28437098-6	2017	The results obtained suggest that interaction between fibrin and the VLDL receptor employs the "double-Lys/Arg" recognition mode previously proposed for the interaction of the LDL receptor family members with their ligands.	Lysine	103-106	very low density lipoprotein receptor	Homo sapiens	69-82
20735436-8	2010	Although DNA methylation of the NIK locus was not detected, NIK expression also increased when the luminal-like subtype was treated with 5-azacytidine, which inhibits histone H3-Lys-9 dimethylation in addition to DNA methylation.	Lysine	178-181	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	60-63
1776140-1	1991	When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK).	Lysine	68-71	plasminogen	Homo sapiens	41-48
1898367-5	1991	The protein sequence of G7a contains two short consensus sequences, His-Ile-Gly-His and Lys-Met-Ser-Lys-Ser, which is the typical signature structure of class I tRNA synthetases and indicative of the presence of the Rossman fold.	Lysine	88-91	valyl-tRNA synthetase 1	Homo sapiens	24-27
20699419-2	2010	Using cultured vascular smooth muscle cells (MVSMC) from type 2 diabetic db/db mice, we recently showed that decreased promoter occupancy of the chromatin histone H3 lysine-9 methyltransferase Suv39h1 and the associated repressive epigenetic mark histone H3 lysine-9 trimethylation (H3K9me3) play key roles in sustained inflammatory gene expression.	Lysine	166-172	suppressor of variegation 3-9 1	Mus musculus	193-200
1898367-5	1991	The protein sequence of G7a contains two short consensus sequences, His-Ile-Gly-His and Lys-Met-Ser-Lys-Ser, which is the typical signature structure of class I tRNA synthetases and indicative of the presence of the Rossman fold.	Lysine	100-103	valyl-tRNA synthetase 1	Homo sapiens	24-27
1909331-3	1991	Since the NH2-terminal part of amphoterin is exceptionally rich in lysine residues, we have studied its interactions with plasminogen and tissue plasminogen activator (t-PA).	Lysine	67-73	high mobility group box 1	Homo sapiens	31-41
20813976-6	2010	Histone H4 lysine acetylation and histone H3 acetylation and phosphorylation in the heat shock element (HSE) of the promoters of heat shock protein-70 (hsp70) and -90 (hsp90) genes were examined.	Lysine	11-17	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	152-157
20734208-6	2010	The modification status of histone H3 lysine 9 (H3-K9) was also closely related to MUC5AC expression.	Lysine	38-44	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	83-89
28494238-5	2017	SMYD2 associated with latent HIV-1 promoter chromatin, which was enriched in monomethylated lysine 20 at histone H4 (H4K20me1), a mark lost in cells lacking SMYD2.	Lysine	92-98	SET and MYND domain containing 2	Homo sapiens	0-5
27765079-5	2017	Birds fed the lowest level of dietary lysine (1.016%) showed a lower expression of genes such as NADH dehydrogenase subunit I (ND1), cytochrome b (CYTB) and cytochrome c oxidase subunits I (COX I), II (COX II) and III (COX III), displaying the worst performance and body protein deposition.	Lysine	38-44	cytochrome c oxidase subunit 3	Glycine max	219-226
1909331-5	1991	In purified systems, both t-PA and plasminogen bound to immobilized amphoterin, and their binding was inhibited by the lysine analogue epsilon-aminocaproic acid.	Lysine	119-125	high mobility group box 1	Homo sapiens	68-78
1909331-9	1991	The results indicate that t-PA and plasminogen form through their lysine-binding sites a complex with amphoterin, which results in acceleration of plasminogen activation and effective degradation of amphoterin.	Lysine	66-72	high mobility group box 1	Homo sapiens	102-112
28209620-2	2017	Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation.	Lysine	11-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	44-47
28209620-2	2017	Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation.	Lysine	11-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	122-125
1909331-9	1991	The results indicate that t-PA and plasminogen form through their lysine-binding sites a complex with amphoterin, which results in acceleration of plasminogen activation and effective degradation of amphoterin.	Lysine	66-72	high mobility group box 1	Homo sapiens	199-209
1916152-4	1991	We amplified and cloned the exon 12 of the ALDH2 gene using polymerase chain reaction (PCR), and revealed that normal GAA coding glutamic acid is replaced for AAA coding lysine in codon 487 of the mutant ALDH2 gene.	Lysine	170-176	aldehyde dehydrogenase 2 family member	Homo sapiens	43-48
28161903-7	2017	A conserved lysine residue in RGS1 (Lys259 ) is directly involved in RGS1-PA binding.	Lysine	12-18	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	30-34
28161903-7	2017	A conserved lysine residue in RGS1 (Lys259 ) is directly involved in RGS1-PA binding.	Lysine	12-18	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	69-73
20870437-1	2010	Zinc-dependent histone deacetylase 8 removes the epsilon-acetyl groups present in the N-terminal lysine residues of histone proteins, thereby restricting various transcription factors from being expressed.	Lysine	97-103	histone deacetylase 8	Homo sapiens	15-36
20863814-9	2010	In conclusion, JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells.	Lysine	139-145	Kruppel like factor 10	Homo sapiens	36-41
20863814-9	2010	In conclusion, JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells.	Lysine	139-145	Kruppel like factor 10	Homo sapiens	81-86
20863814-9	2010	In conclusion, JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells.	Lysine	139-145	Kruppel like factor 10	Homo sapiens	81-86
1916152-4	1991	We amplified and cloned the exon 12 of the ALDH2 gene using polymerase chain reaction (PCR), and revealed that normal GAA coding glutamic acid is replaced for AAA coding lysine in codon 487 of the mutant ALDH2 gene.	Lysine	170-176	aldehyde dehydrogenase 2 family member	Homo sapiens	204-209
28167662-4	2017	Correspondingly, in GCB-derived cell lines, the IRE1 promoter carried increased levels of the repressive epigenetic mark histone 3 lysine 27 trimethylation.	Lysine	131-137	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	48-52
20949080-8	2010	Microarray and chromatin immunoprecipitation analyses showed that LAZ2/SDG8 is required for LAZ5 expression and H3 lysine 36 trimethylation at LAZ5 chromatin to maintain a transcriptionally active state.	Lysine	115-121	histone-lysine N-methyltransferase	Arabidopsis thaliana	66-70
20949080-8	2010	Microarray and chromatin immunoprecipitation analyses showed that LAZ2/SDG8 is required for LAZ5 expression and H3 lysine 36 trimethylation at LAZ5 chromatin to maintain a transcriptionally active state.	Lysine	115-121	histone-lysine N-methyltransferase	Arabidopsis thaliana	71-75
1886613-1	1991	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) is the first committed enzyme in the lysine branch of the aspartate-derived amino acid biosynthesis pathway and is common to bacteria and plants.	Lysine	86-92	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-28
20798608-3	2010	Recently, we found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediates Lys(63) (K63)- linked ubiquitination of Beclin 1 is crucial for TLR4-triggered autophagy in macrophages.	Lysine	99-102	TNF receptor associated factor 6	Homo sapiens	83-88
20798608-3	2010	Recently, we found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediates Lys(63) (K63)- linked ubiquitination of Beclin 1 is crucial for TLR4-triggered autophagy in macrophages.	Lysine	99-102	toll like receptor 4	Homo sapiens	163-167
20682767-6	2010	We show that ZFP91 interacts with and promotes the Lys(63)-linked ubiquitination of NIK and subsequent processing of p100 to p52.	Lysine	51-54	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	84-87
28371162-5	2017	FPheK reacted with adjacent Lys, Cys, and Tyr residues in thioredoxin in high yields.	Lysine	28-31	thioredoxin	Homo sapiens	58-69
1886613-1	1991	Dihydrodipicolinate synthase (DHPS; EC 4.2.1.52) is the first committed enzyme in the lysine branch of the aspartate-derived amino acid biosynthesis pathway and is common to bacteria and plants.	Lysine	86-92	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	30-34
28371162-6	2017	In addition, crosslinks could be formed between FPheK and Lys residue of two interacting proteins, including the heavy chain and light chain of an antibody Fab.	Lysine	58-61	FA complementation group B	Homo sapiens	156-159
1886613-2	1991	Due to feedback inhibition by lysine, DHPS serves in a regulatory role for this pathway in plant metabolism.	Lysine	30-36	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	38-42
1886613-4	1991	The maize DHPS activity expressed in the complemented E. coli auxotroph showed the lysine inhibition characteristics of purified maize DHPS, indicating that the cDNA encoded sequences for both the catalytic function and regulatory properties of the enzyme.	Lysine	83-89	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	10-14
20832885-8	2010	Moreover, Lys/Gln+Gln/Gln genotypes of XPD Lys751Gln polymorphism were also associated with a significantly decreased RIET risk (adjusted HR=0.55; 95% CI=0.32-0.96; P=0.030).	Lysine	10-13	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	39-42
1886613-4	1991	The maize DHPS activity expressed in the complemented E. coli auxotroph showed the lysine inhibition characteristics of purified maize DHPS, indicating that the cDNA encoded sequences for both the catalytic function and regulatory properties of the enzyme.	Lysine	83-89	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	135-139
28318385-8	2017	We further showed that K10 and K524 were 2 lysine residues essential for Mus81 sumoylation.	Lysine	43-49	MUS81 structure-specific endonuclease subunit	Homo sapiens	73-78
1905927-1	1991	We have shown the increase in the acetyl-CoA-independent activity of sheep liver pyruvate carboxylase following trinitrophenylation of a specific lysine residue (designated Lys-A) to be the result of a large stimulation of the first partial reaction and a slight stimulation of the second partial reaction catalysed by this enzyme.	Lysine	146-152	pyruvate carboxylase, mitochondrial	Ovis aries	81-101
28131055-1	2017	Lysine-MCC-DM1, MCC-DM1 and DM1 are potential catabolites of trastuzumab emtansine (T-DM1).	Lysine	0-6	immunoglobulin heavy diversity 1-7	Homo sapiens	11-14
28406396-0	2017	SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.	Lysine	46-52	RAS related 2	Homo sapiens	16-42
28406396-3	2017	Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a member of the Ras family.	Lysine	69-75	RAS related 2	Homo sapiens	103-109
20816089-3	2010	Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.	Lysine	250-256	sirtuin 1	Mus musculus	19-24
28406396-4	2017	SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.	Lysine	75-81	RAS related 2	Homo sapiens	101-107
16668206-1	1991	Dihydrodipicolinate synthase (EC 4.2.1.52), the first enzyme specific to lysine biosynthesis in plants, was purified from maize (Zea mays L.) cell suspension cultures and leaves.	Lysine	73-79	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	0-28
28406396-6	2017	Lysine fatty acylation promotes the plasma membrane localization of R-Ras2 and its interaction with phosphatidylinositol 3-kinase PI3K, leading to activated Akt and increased cell proliferation.	Lysine	0-6	RAS related 2	Homo sapiens	68-74
20797627-4	2010	We addressed the mechanistic basis for this lysine selectivity in Ubc1, an E2 that catalyzes the ubiquitination of lysine 48 (K48) in ubiquitin, leading to the formation of K48-linked polyubiquitin chains.	Lysine	44-50	ubiquitin conjugating enzyme E2 K	Homo sapiens	66-70
20797627-4	2010	We addressed the mechanistic basis for this lysine selectivity in Ubc1, an E2 that catalyzes the ubiquitination of lysine 48 (K48) in ubiquitin, leading to the formation of K48-linked polyubiquitin chains.	Lysine	115-121	ubiquitin conjugating enzyme E2 K	Homo sapiens	66-70
20797627-5	2010	We identified a cluster of polar residues near the Ubc1 active site, as well as a residue in ubiquitin itself, that are required for catalysis of K48-specific ubiquitin ligation, but not for general activity toward other lysines.	Lysine	221-228	ubiquitin conjugating enzyme E2 K	Homo sapiens	51-55
20797627-6	2010	Our results suggest that the active site of Ubc1, as well as the surface of ubiquitin, contains specificity determinants that channel specific lysines to the central residues involved directly in catalysis.	Lysine	143-150	ubiquitin conjugating enzyme E2 K	Homo sapiens	44-48
28326190-6	2017	Mechanistically, in the proliferating myoblasts, Malat1 recruits Suv39h1 to MyoD-binding loci, causing trimethylation of histone 3 lysine 9 (H3K9me3), which suppresses the target gene expression.	Lysine	131-137	suppressor of variegation 3-9 1	Mus musculus	65-72
16668206-7	1991	Lysine was an allosteric cooperative inhibitor of dihydrodipicolinate synthase with an estimated Hill number of 4 and 23 micromolar concentration required for 50% inhibition.	Lysine	0-6	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Zea mays	50-78
2017168-2	1991	The Ste2 and beta la components were linked by a processing fragment (P) from the yeast killer preprotoxin containing a C-terminal lysine-arginine site for cleavage by the Golgi-associated Kex2 protease.	Lysine	131-137	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	4-8
28290497-1	2017	Sister-chromatid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit.	Lysine	94-101	establishment of sister chromatid cohesion N-acetyltransferase 1 L homeolog	Xenopus laevis	44-48
20808952-0	2010	MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.	Lysine	47-53	lysine methyltransferase 2D	Homo sapiens	0-4
20691906-2	2010	Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc.	Lysine	119-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
20691906-2	2010	Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc.	Lysine	119-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-72
20691906-2	2010	Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc.	Lysine	119-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-72
1688125-0	1991	Three high-lysine mutations control the level of ATP-binding HSP70-like proteins in the maize endosperm.	Lysine	11-17	heat shock cognate 70 kDa protein 2	Zea mays	61-66
20600146-10	2010	The blockage of PI3K by LY 294002 reduced melatonin synthesis and AANAT activity.	Lysine	24-26	aralkylamine N-acetyltransferase	Rattus norvegicus	66-71
20603103-3	2010	The attachment of Nedd8 to its substrates occurs via a process analogous to ubiquitin transfer, involving a Nedd8 E1 activating enzyme and a Nedd8 E2 conjugating enzyme, Ubc12, which transfers Nedd8 onto lysine residues of target proteins.	Lysine	204-210	ubiquitin conjugating enzyme E2 M	Homo sapiens	170-175
28122914-5	2017	Notably, NDR2 puncta mostly co-localized with the peroxisome marker proteins, catalase and CFP-SKL (cyan fluorescent protein carrying the C-terminal typical peroxisome-targeting signal type-1 (PTS1) sequence, Ser-Lys-Leu).	Lysine	213-216	serine/threonine kinase 38 like	Homo sapiens	9-13
28122914-6	2017	NDR2 contains the PTS1-like sequence, Gly-Lys-Leu, at the C-terminal end, whereas the C-terminal end of NDR1 is Ala-Lys.	Lysine	42-45	serine/threonine kinase 38 like	Homo sapiens	0-4
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Lysine	329-332	prolactin receptor	Homo sapiens	89-102
28135087-2	2017	GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates.	Lysine	90-96	euchromatic histone lysine methyltransferase 1	Homo sapiens	0-3
20668706-0	2010	SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.	Lysine	119-125	sirtuin 1	Mus musculus	0-5
20668706-6	2010	SIRT1 deacetylated two specific lysine residues (K265/K268) in PIP5Kgamma and enhanced PIP5Kgamma enzyme activity.	Lysine	32-38	sirtuin 1	Mus musculus	0-5
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Lysine	338-341	prolactin receptor	Homo sapiens	89-102
1829277-6	1991	The effect of AHA suggests a specific involvement of lysine binding sites (LBS) on plasmin in the interaction of the enzyme with aspirin.	Lysine	53-59	plasminogen	Homo sapiens	83-90
20452361-3	2010	Here, we demonstrate that the third PHD domain of MLL (PHD3) binds histone H3 trimethylated at lysine 4 (H3K4me3) with high affinity and specificity and H3K4me2 with 8-fold lower affinity.	Lysine	95-101	lysine methyltransferase 2A	Homo sapiens	50-53
20603083-0	2010	Lysine methylation regulates E2F1-induced cell death.	Lysine	0-6	E2F transcription factor 1	Homo sapiens	29-33
20603083-3	2010	Set9 methylates E2F1 at lysine-185, which prevents E2F1 accumulation during DNA damage and activation of its proapoptotic target gene p73.	Lysine	24-30	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
20603083-3	2010	Set9 methylates E2F1 at lysine-185, which prevents E2F1 accumulation during DNA damage and activation of its proapoptotic target gene p73.	Lysine	24-30	E2F transcription factor 1	Homo sapiens	16-20
20603083-3	2010	Set9 methylates E2F1 at lysine-185, which prevents E2F1 accumulation during DNA damage and activation of its proapoptotic target gene p73.	Lysine	24-30	E2F transcription factor 1	Homo sapiens	51-55
20603083-5	2010	The molecular mechanism involves crosstalks between lysine methylation and other covalent modifications that affect E2F1 stability.	Lysine	52-58	E2F transcription factor 1	Homo sapiens	116-120
28278223-6	2017	The carboxylate clamp interactions with bound Hsp90 peptide were a critical component of the interaction and mutation of Lys 307, involved in the carboxylate clamp, completely disrupted the interaction with Hsp90.	Lysine	121-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-51
28278223-6	2017	The carboxylate clamp interactions with bound Hsp90 peptide were a critical component of the interaction and mutation of Lys 307, involved in the carboxylate clamp, completely disrupted the interaction with Hsp90.	Lysine	121-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	207-212
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Lysine	27-33	bactericidal permeability increasing protein	Sus scrofa	124-127
28616572-0	2017	Reversible lysine acetylation regulates nuclear translocation of TyrRS to counteract genotoxic oxidative stress.	Lysine	11-17	tyrosyl-tRNA synthetase 2	Homo sapiens	65-70
1782747-2	1991	The structure of the apolipoprotein CII variant was determined to be the same as normal apolipoprotein CII except for replacement of the normal Lys at amino acid residue 19 by Thr (C2K19T).	Lysine	144-147	apolipoprotein C2	Homo sapiens	21-39
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	71-77	sodium voltage-gated channel alpha subunit 5	Homo sapiens	61-67
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	114-120	sodium voltage-gated channel alpha subunit 5	Homo sapiens	61-67
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	114-120	sodium voltage-gated channel alpha subunit 5	Homo sapiens	159-165
20613989-1	2010	BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev.	Lysine	263-269	ring finger protein 8	Homo sapiens	77-81
20613989-1	2010	BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev.	Lysine	263-269	proliferating cell nuclear antigen	Homo sapiens	127-131
20613989-1	2010	BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains, catalyzed by the conserved ubiquitin conjugating heterodimeric enzyme Ubc13-Uev.	Lysine	263-269	ubiquitin conjugating enzyme E2 N	Homo sapiens	375-380
20613989-3	2010	In mammalian cells, they inhibit lysine 63-type polyubiquitylation of PCNA, inhibit activation of NF-kappaB by TNF-alpha and sensitize tumor cells to chemotherapeutic agents.	Lysine	33-39	proliferating cell nuclear antigen	Homo sapiens	70-74
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	mitochondrial antiviral signaling protein	Homo sapiens	242-246
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	mitochondrial antiviral signaling protein	Homo sapiens	247-252
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	mitochondrial antiviral signaling protein	Homo sapiens	253-259
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	mitochondrial antiviral signaling protein	Homo sapiens	260-264
20498091-1	2010	The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site.	Lysine	91-94	proliferating cell nuclear antigen	Homo sapiens	46-80
28191886-6	2017	Increased Sirt1 activity or expression results in decreased lysine acetylation of Nav1.5, which promotes the trafficking of Nav1.5 to the plasma membrane and stimulation of INa.	Lysine	60-66	sodium voltage-gated channel alpha subunit 5	Homo sapiens	82-88
28191886-6	2017	Increased Sirt1 activity or expression results in decreased lysine acetylation of Nav1.5, which promotes the trafficking of Nav1.5 to the plasma membrane and stimulation of INa.	Lysine	60-66	sodium voltage-gated channel alpha subunit 5	Homo sapiens	124-130
20498091-1	2010	The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site.	Lysine	91-94	proliferating cell nuclear antigen	Homo sapiens	82-86
2013406-1	1991	The Saccharomyces cerevisiae LYS2 gene, which encodes alpha-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced.	Lysine	117-123	L-aminoadipate-semialdehyde dehydrogenase	Saccharomyces cerevisiae S288C	29-33
20498091-1	2010	The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site.	Lysine	91-94	proliferating cell nuclear antigen	Homo sapiens	201-205
20498091-2	2010	Although a number of genetic and biochemical observations have provided strong evidence that TLS Pols bind PCNA at its interdomain connector loop (IDCL) via their PCNA-interacting protein (PIP) domain, a more recent proposal formulates that TLS Pols bind PCNA at two sites, to the IDCL via their PIP domain and to lys-164 linked ubiquitin (Ub) via their ubiquitin-binding domain.	Lysine	314-317	proliferating cell nuclear antigen	Homo sapiens	107-111
28357416-3	2017	However, we have recently discovered a novel KMT that appeared to have a more relaxed sequence specificity, namely, valosin-containing protein (VCP)-KMT, which trimethylates Lys-315 in the molecular chaperone VCP.	Lysine	174-177	valosin containing protein lysine methyltransferase	Homo sapiens	116-152
28357416-4	2017	On the basis of this, here, we explored the possibility of using the VCP-KMT/VCP system to obtain specific lysine methylation of desired sequences grafted onto a VCP-derived scaffold.	Lysine	107-113	valosin containing protein lysine methyltransferase	Homo sapiens	69-76
2016271-7	1991	Purified rh-prorenin was almost inactive, but was cleaved at the carboxyl end of a dibasic pair Lys-2-Arg-1 by trypsin and converted to active renin.	Lysine	96-99	arginase 1	Homo sapiens	102-107
27984186-1	2017	Glutaryl-CoA dehydrogenase (GCDH) is a mitochondrial enzyme that is involved in the degradation of tryptophan, lysine and hydroxylysine.	Lysine	111-117	glutaryl-CoA dehydrogenase	Rattus norvegicus	0-26
27984186-1	2017	Glutaryl-CoA dehydrogenase (GCDH) is a mitochondrial enzyme that is involved in the degradation of tryptophan, lysine and hydroxylysine.	Lysine	111-117	glutaryl-CoA dehydrogenase	Rattus norvegicus	28-32
28028172-0	2017	Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.	Lysine	113-119	histone deacetylase 1	Mus musculus	0-21
28028172-0	2017	Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.	Lysine	137-143	histone deacetylase 1	Mus musculus	0-21
28028172-3	2017	Inhibition of HDAC1 resulted in increase of acetylation of lysine 9 of histone 3 (H3K9) and lysine 12 of histone 4 (H4K12) but not lysine 27 of histone 3 (H3K27) and led to maintained expression of progenitor-specific genes such as Vsx2 and Hes1 with concomitant block of expression of rod-specific genes.	Lysine	59-65	histone deacetylase 1	Mus musculus	14-19
28028172-3	2017	Inhibition of HDAC1 resulted in increase of acetylation of lysine 9 of histone 3 (H3K9) and lysine 12 of histone 4 (H4K12) but not lysine 27 of histone 3 (H3K27) and led to maintained expression of progenitor-specific genes such as Vsx2 and Hes1 with concomitant block of expression of rod-specific genes.	Lysine	92-98	histone deacetylase 1	Mus musculus	14-19
20075941-4	2010	The suppressive action of NO on Nanog gene depends on the activation of p53 repressor protein by covalent modifications, such as pSer15, pSer315, pSer392 and acetyl Lys 379.	Lysine	165-168	transformation related protein 53, pseudogene	Mus musculus	72-75
20227435-2	2010	Dihydrodipicolinate synthase (DHDPS) catalyzes the branch point reaction leading to meso-diaminopimelate (DAP) and (S)-lysine in lysine biosynthesis.	Lysine	115-125	dihydrodipicolinate synthase	Escherichia coli	0-28
20227435-2	2010	Dihydrodipicolinate synthase (DHDPS) catalyzes the branch point reaction leading to meso-diaminopimelate (DAP) and (S)-lysine in lysine biosynthesis.	Lysine	115-125	dihydrodipicolinate synthase	Escherichia coli	30-35
20227435-2	2010	Dihydrodipicolinate synthase (DHDPS) catalyzes the branch point reaction leading to meso-diaminopimelate (DAP) and (S)-lysine in lysine biosynthesis.	Lysine	119-125	dihydrodipicolinate synthase	Escherichia coli	0-28
20227435-2	2010	Dihydrodipicolinate synthase (DHDPS) catalyzes the branch point reaction leading to meso-diaminopimelate (DAP) and (S)-lysine in lysine biosynthesis.	Lysine	119-125	dihydrodipicolinate synthase	Escherichia coli	30-35
20501938-0	2010	TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.	Lysine	23-29	TNF receptor associated factor 6	Homo sapiens	0-5
20501938-0	2010	TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.	Lysine	23-29	toll like receptor 4	Homo sapiens	78-82
20501938-3	2010	We found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediated, Lys(63) (K63)-linked ubiquitination of Beclin-1 is critical for TLR4-triggered autophagy in macrophages.	Lysine	90-93	TNF receptor associated factor 6	Homo sapiens	73-78
20501938-3	2010	We found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediated, Lys(63) (K63)-linked ubiquitination of Beclin-1 is critical for TLR4-triggered autophagy in macrophages.	Lysine	90-93	toll like receptor 4	Homo sapiens	154-158
28028849-10	2017	Chromatin immunoprecipitation assay was performed to determine the status of histone H3 lysine 9 acetylation (H3K9Ac) on the promoter of the beta3 -adrenergic receptor (ARbeta3) gene in epididymal white adipose tissue.	Lysine	88-94	adrenergic receptor, beta 3	Mus musculus	141-167
2279701-2	1990	Alteration of the tetra-basic amino acid sequence (Arg84-Arg-Lys-Arg to Arg-Ser-Asn-Gly) results in the formation of stable pro-PDGF-A homodimers that lack mitogenic activity.	Lysine	61-64	platelet derived growth factor, alpha	Mus musculus	128-134
20304918-7	2010	TAX1BP1 and A20 blocked antiviral signaling by disrupting Lys(63)-linked polyubiquitination of TBK1-IKKi independently of the A20 deubiquitination domain.	Lysine	58-61	Tax1 (human T cell leukemia virus type I) binding protein 1	Mus musculus	0-7
20304918-7	2010	TAX1BP1 and A20 blocked antiviral signaling by disrupting Lys(63)-linked polyubiquitination of TBK1-IKKi independently of the A20 deubiquitination domain.	Lysine	58-61	inhibitor of kappaB kinase epsilon	Mus musculus	100-104
20307547-7	2010	The signature HKKme2 motif of p53, which defines specificity, is identified through a combination of NMR resonance perturbations, mutagenesis, measurements of binding affinities and docking simulations, and analysis of the crystal structures of 53BP1 bound to p53 peptides containing other dimethyl-lysine marks, p53K370me2 (p53 dimethylated at Lys370) and p53K372me2 (p53 dimethylated at Lys372).	Lysine	299-305	tumor protein p53 binding protein 1	Homo sapiens	245-250
20082324-4	2010	We show here that in a Drosophila CtBP mutant background, intergenic transcripts are induced across several PRE sequences and this corresponds to reduced DNA binding by PcG proteins Pleiohomeotic (PHO) and Polycomb (Pc), and reduced trimethylation of histone H3 on lysine 27, a hallmark of PcG repression.	Lysine	265-271	C-terminal Binding Protein	Drosophila melanogaster	34-38
27436852-8	2017	The RelA NF-kappaB subunit is activated by acetylation of lysine 310.	Lysine	58-64	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	4-8
1705373-9	1990	In the other mutants, one substitution in position 239 of a lysine for a methionine was correlated with an increased neuraminidase activity of strain M12, while a substitution in position 360 of an arginine for a cysteine appeared to represent the most likely explanation for the reduced neurovirulence of strain M13.	Lysine	60-66	neuraminidase 1	Homo sapiens	117-130
27540894-9	2017	Sirt3-targeted siRNA decreased SOD2 activity by reducing deacetylation of lysine 68 of SOD2, leading to increased osteoclastogenesis.	Lysine	74-80	sirtuin 3	Mus musculus	0-5
20082324-5	2010	Restoration of CtBP levels by expression of a CtBP transgene results in repression of intergenic transcripts, restored PcG binding, and elevated trimethylation of H3 on lysine 27.	Lysine	169-175	C-terminal Binding Protein	Drosophila melanogaster	15-19
20082324-5	2010	Restoration of CtBP levels by expression of a CtBP transgene results in repression of intergenic transcripts, restored PcG binding, and elevated trimethylation of H3 on lysine 27.	Lysine	169-175	C-terminal Binding Protein	Drosophila melanogaster	46-50
2168396-7	1990	Tryptic digestion of cG-BPDE phosphorylated by cGK and [gamma-32P]ATP produced a single major phosphopeptide of approximately 2 kDa with the following amino-terminal sequence: Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg- Radioactivity was released during the third cycle of Edman degradation.	Lysine	176-179	phosphodiesterase 5A	Bos taurus	21-28
20351197-3	2010	In response to both 17beta-estradiol (E2) and the xenoestrogen diethylstilbestrol, ER signaling via phosphatidylinositol 3-kinase/protein kinase B phosphorylates EZH2 at S21, reducing levels of trimethylation of lysine 27 on histone H3 in hormone-responsive cells.	Lysine	212-218	protein tyrosine kinase 2 beta	Homo sapiens	130-146
28031478-2	2017	Here, we show that TRIM65 specifically interacts with MDA5 and promotes K63-linked ubiquitination of MDA5 at lysine 743, which is critical for MDA5 oligomerization and activation.	Lysine	109-115	interferon induced with helicase C domain 1	Homo sapiens	54-58
28031478-2	2017	Here, we show that TRIM65 specifically interacts with MDA5 and promotes K63-linked ubiquitination of MDA5 at lysine 743, which is critical for MDA5 oligomerization and activation.	Lysine	109-115	interferon induced with helicase C domain 1	Homo sapiens	101-105
28031478-2	2017	Here, we show that TRIM65 specifically interacts with MDA5 and promotes K63-linked ubiquitination of MDA5 at lysine 743, which is critical for MDA5 oligomerization and activation.	Lysine	109-115	interferon induced with helicase C domain 1	Homo sapiens	101-105
20177150-6	2010	The nuclear export induced by the re-addition of serum or growth factors was prevented by LY 294002 and SH-5, inhibitors of phosphoinositide 3-kinase (PI3K) and Akt/protein kinase B, respectively, suggesting an involvement of the PI3K signaling pathway in the nuclear export of GAPDH.	Lysine	90-92	protein tyrosine kinase 2 beta	Homo sapiens	165-181
2384754-5	1990	On the basis of these findings, it is suggested that at pH 9, NBD-Cl modifies one (or more) essential lysine residue(s) in the active sites of the two types of MAO.	Lysine	102-108	monoamine oxidase A	Rattus norvegicus	160-163
20385835-3	2010	We have used the eukaryotic replication clamp PCNA, a natural target of lysine (K)63-linked polyubiquitylation, as a model substrate to directly compare the consequences of modification by different types of polyubiquitin chains.	Lysine	72-78	proliferating cell nuclear antigen	Homo sapiens	46-50
27868254-8	2017	Furthermore, we identify lysine 30 and 271 as critical acetylation sites on C. albicans Hsp90, and substitutions at these residues compromise Hsp90 function.	Lysine	25-31	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	88-93
27868254-8	2017	Furthermore, we identify lysine 30 and 271 as critical acetylation sites on C. albicans Hsp90, and substitutions at these residues compromise Hsp90 function.	Lysine	25-31	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	142-147
28361100-2	2017	EHMT1 (MIM# 607001) encodes a histone methyltransferase that heterodimerizes with EHMT2 (also known as G9a, MIM# 604599), which together are responsible for mono- and dimethylation of H3 lysine 9 (H3K9me1 and -me2), resulting in transcriptional repression of target genes.	Lysine	187-193	euchromatic histone lysine methyltransferase 1	Homo sapiens	0-5
20419159-6	2010	We show that K5 targets a single lysine (K18) in the cytoplasmic tail of tetherin for ubiquitination, leading to relocalization of tetherin to CD63-positive endosomal compartments.	Lysine	33-39	CD63 molecule	Homo sapiens	143-147
2143185-9	1990	In contrast, partial inhibition by Glu-plasminogen of t-PA K2 domain-mediated fibrin binding is observed that is dependent on carboxyl-terminal lysines, exposed in fibrin upon limited plasmin digestion.	Lysine	144-151	plasminogen	Homo sapiens	39-46
1973167-4	1990	Using molecular techniques, two point mutations were detected in the coding sequence of the FX Vorarlberg gene: a G----A at base pair 160 in exon II resulting in a change of Gla14 (GAA) to Lys (AAA); a G----A at base pair 424 in exon V resulting in a change from Glu102 (GAG) to Lys (AAG).	Lysine	189-192	alpha glucosidase	Homo sapiens	181-184
20150895-5	2010	Blocking this tonic ubiquitylation by mutating all the lysines in the CD3 cytoplasmic tails significantly upregulates TCR levels on DP thymocytes.	Lysine	55-62	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	118-121
1973167-4	1990	Using molecular techniques, two point mutations were detected in the coding sequence of the FX Vorarlberg gene: a G----A at base pair 160 in exon II resulting in a change of Gla14 (GAA) to Lys (AAA); a G----A at base pair 424 in exon V resulting in a change from Glu102 (GAG) to Lys (AAG).	Lysine	279-282	alpha glucosidase	Homo sapiens	181-184
20230194-4	2010	AREAS COVERED IN THIS REVIEW: The histone methyltransferase DOT1L is responsible for methylation of histone H3 at lysine 79 and is involved in the pathobiology of several leukemias, the majority of which are characterized by chromosomal translocations involving the mixed lineage leukemia (MLL) gene.	Lysine	114-120	lysine methyltransferase 2A	Homo sapiens	290-293
28036303-3	2017	Here we report that PKM2 is succinylated at lysine 498 (K498) and succinylation increases its activity.	Lysine	44-50	pyruvate kinase M1/2	Homo sapiens	20-24
2361732-3	1990	The slow form of cystatin C possessed the N-terminal tetrapeptide Lys Pro Pro Arg, which was cleaved in the fast form.	Lysine	66-69	cystatin C	Homo sapiens	17-27
28102357-1	2017	The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c.	Lysine	88-94	trace amine associated receptor 13c	Danio rerio	191-198
20210853-6	2010	Site-directed mutagenesis analysis of AANAT revealed that the AANAT degradation is independent of lysine and the two surface cysteine residues.	Lysine	98-104	aralkylamine N-acetyltransferase	Rattus norvegicus	62-67
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Lysine	142-145	pro-platelet basic protein	Homo sapiens	0-20
20042594-4	2010	Here we show the pivotal role of the covalent bond between the retinal chromophore and the lysine residue at position 296 in the activation pathway of bovine rhodopsin, by use of a rhodopsin mutant K296G reconstituted with retinylidene Schiff bases.	Lysine	91-97	rhodopsin	Bos taurus	158-167
20042594-4	2010	Here we show the pivotal role of the covalent bond between the retinal chromophore and the lysine residue at position 296 in the activation pathway of bovine rhodopsin, by use of a rhodopsin mutant K296G reconstituted with retinylidene Schiff bases.	Lysine	91-97	rhodopsin	Bos taurus	181-190
27881643-12	2017	Acetylation on lysine (K) 40 of alpha-tubulin is an evolutionarily conserved modification and plays an important role in many cellular processes, but its role in viral IB dynamics has not been fully explored.	Lysine	15-21	tubulin alpha 1b	Homo sapiens	32-45
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Lysine	142-145	pro-platelet basic protein	Homo sapiens	22-29
27926517-6	2017	Moreover, cell cycle real-time PCR array and proteome profiler antibody array confirmed that Leptin and SAHA treatment significantly changed the expressions of factors associated with cell cycle regulation and apoptosis including p53 and p21WAF1/CIP1.In DNA-ChIP analysis, we found that acetylation levels binding with p21WAF1/CIP1 promoters are regulated in a manner specific to histone type, lysine residue and selective promoter regions.	Lysine	394-400	leptin	Homo sapiens	93-99
2141792-2	1990	beta-Thromboglobulin (beta TG) is an 81-residue peptide which is derived from CTAP-III by cleavage of the N-terminal tetrapeptide Asn-Leu-Ala-Lys which results in the loss of mitogenic activity.	Lysine	142-145	pro-platelet basic protein	Homo sapiens	78-86
2141792-7	1990	This predicted structural difference appears to be due to the high helix-forming potential of the N-terminal tetrapeptide Asn-Leu-Ala-Lys in CTAP-III.	Lysine	134-137	pro-platelet basic protein	Homo sapiens	141-149
20170637-0	2010	Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity.	Lysine	49-55	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	95-111
27827827-1	2017	K(lysine) acetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis.	Lysine	2-8	K(lysine) acetyltransferase 8	Mus musculus	31-35
2109688-2	1990	Two antisera (Anti-P7 and Anti-P10) were raised against (-Gln-His-Pro-Gly-) elongated peptides: P7 Gln-His-Pro-Gly-Lys-Arg-Phe) and P10 (Ser-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Phe).	Lysine	115-118	S100 calcium binding protein A10 (calpactin)	Mus musculus	31-34
27827827-1	2017	K(lysine) acetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis.	Lysine	2-8	K(lysine) acetyltransferase 8	Mus musculus	51-54
20205709-9	2010	We also demonstrate that SUMOylation of PML at Lysine positions K160 and/or K490 are required for nuclear body formation in vivo.We propose a model in which the isoform specific residence times of PML provide both, structural stability to function as a scaffold and flexibility to attract specific nuclear proteins for efficient biochemical reactions at the surface of nuclear bodies.MCS code: 92C37.	Lysine	47-53	PML nuclear body scaffold	Homo sapiens	40-43
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	198-201	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
20205709-9	2010	We also demonstrate that SUMOylation of PML at Lysine positions K160 and/or K490 are required for nuclear body formation in vivo.We propose a model in which the isoform specific residence times of PML provide both, structural stability to function as a scaffold and flexibility to attract specific nuclear proteins for efficient biochemical reactions at the surface of nuclear bodies.MCS code: 92C37.	Lysine	47-53	PML nuclear body scaffold	Homo sapiens	197-200
27916662-3	2017	Here, we demonstrate that acetylation of lysine residues at the inner surface of PCNA is induced by DNA lesions.	Lysine	41-47	proliferating cell nuclear antigen	Homo sapiens	81-85
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Lysine	206-209	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
20025926-2	2010	DHDPS catalyses the first committed step in (S)-lysine biosynthesis: the Schiff-base mediated aldol condensation of pyruvate with (S)-aspartate semi-aldehyde.	Lysine	44-54	dihydrodipicolinate synthase	Escherichia coli	0-5
1692865-4	1990	Although a corresponding sequence of amino acids in the IFN-beta molecule was localized to the region 134-139 and shows only a 66% homology with the assumed IFN-alpha 2 binding site, lysine at position 132 in IFN-alpha 2 and at position 134 in IFN-beta seems to be crucial for establishment of the common epitope.	Lysine	183-189	interferon beta 1	Homo sapiens	56-64
19787286-7	2010	In regard to the mechanism of mucin expression, we have recently reported that MUC1, MUC2, MUC4, and MUC5AC gene expression is regulated by epigenetics (DNA methylation and histone H3 lysine 9 modification) in cancer cell lines, including PDAC cells.	Lysine	184-190	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	101-107
20071374-9	2010	In the dehydrated state, GmPM1 and GmPM28 interact with non-reducing sugars to improve the transition temperature of cellular glass, with poly-l-lysine to prevent dehydration-induced aggregation and with phospholipids to maintain the liquid crystal phase over a wide temperature range.	Lysine	138-151	late embryogenesis abundant group 4 protein PM1	Glycine max	25-30
27799292-3	2017	FADD was modified at multiple lysine residues (K120/125/149) by small ubiquitin-related modifier 2 (SUMO2) during necrosis caused by calcium ionophore A23187 and by ischemic damage.	Lysine	30-36	Fas associated via death domain	Homo sapiens	0-4
28452589-1	2017	Lysyl oxidase (LOX) catalyzes the oxidative deamination of lysine residues in collagen and elastin, key components of connective tissue.	Lysine	59-65	elastin	Mus musculus	91-98
1692865-4	1990	Although a corresponding sequence of amino acids in the IFN-beta molecule was localized to the region 134-139 and shows only a 66% homology with the assumed IFN-alpha 2 binding site, lysine at position 132 in IFN-alpha 2 and at position 134 in IFN-beta seems to be crucial for establishment of the common epitope.	Lysine	183-189	interferon alpha 2	Homo sapiens	157-168
1692865-4	1990	Although a corresponding sequence of amino acids in the IFN-beta molecule was localized to the region 134-139 and shows only a 66% homology with the assumed IFN-alpha 2 binding site, lysine at position 132 in IFN-alpha 2 and at position 134 in IFN-beta seems to be crucial for establishment of the common epitope.	Lysine	183-189	interferon alpha 2	Homo sapiens	209-220
19955185-4	2010	In this report, we demonstrate that hPPARalpha is SUMOylated by SUMO-1 on lysine 185 in the hinge region.	Lysine	74-80	peroxisome proliferator activated receptor alpha	Homo sapiens	36-46
2159781-0	1990	Effect of chemical modification of lysine amino groups on redox and protonmotive activity of bovine heart cytochrome c oxidase reconstituted in phospholipid membranes.	Lysine	35-41	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	106-126
27842487-10	2017	RESULTS: We found in our study the basic amino acids His13 and Lys 16 of Abeta peptide to be crucial for the interaction with bexarotene.	Lysine	63-66	amyloid beta (A4) precursor protein	Mus musculus	73-78
2159781-1	1990	A study is presented of the effect of chemical modification of lysine amino groups on the redox and protonmotive activity of bovine heart cytochrome c oxidase.	Lysine	63-69	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	138-158
20188669-4	2010	Within these subnuclear structures IKKepsilon inducibly colocalizes with TOPORS, which functions as a SUMO E3 ligase mediating SUMOylation of IKKepsilon at lysine 231.	Lysine	156-162	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	35-45
2322278-4	1990	As the fusion protein was designed to be connected through lysine residue, elastase activity was generated after digestion of the fusion protein with lysyl-endopeptidase.	Lysine	59-65	elastase, neutrophil expressed	Homo sapiens	75-83
20188669-4	2010	Within these subnuclear structures IKKepsilon inducibly colocalizes with TOPORS, which functions as a SUMO E3 ligase mediating SUMOylation of IKKepsilon at lysine 231.	Lysine	156-162	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	73-79
20188669-4	2010	Within these subnuclear structures IKKepsilon inducibly colocalizes with TOPORS, which functions as a SUMO E3 ligase mediating SUMOylation of IKKepsilon at lysine 231.	Lysine	156-162	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	142-152
28948132-3	2017	For Py-Tag labelled lysine, sensitive signals that showed less noise with a ten times higher sensitivity, showed a wider mass difference by Nano-PALDI MS compared to MALDI MS.	Lysine	20-26	long intergenic non-protein coding RNA 1194	Homo sapiens	7-10
2108161-2	1990	The biosynthesis of deoxyhypusine (N-(4-aminobutyl)lysine) occurs by the transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in a precursor of eukaryotic translation initiation factor 4D (eIF-4D).	Lysine	51-57	eukaryotic translation initiation factor 5A	Rattus norvegicus	170-213
27929370-4	2016	We now report: (1) that this ANGPTL4 variant is less efficient in catalyzing the unfolding of LPL; and (2) that its Glu-to-Lys substitution destabilizes its N-terminal alpha-helix.	Lysine	123-126	angiopoietin like 4	Homo sapiens	29-36
27929370-4	2016	We now report: (1) that this ANGPTL4 variant is less efficient in catalyzing the unfolding of LPL; and (2) that its Glu-to-Lys substitution destabilizes its N-terminal alpha-helix.	Lysine	123-126	lipoprotein lipase	Homo sapiens	94-97
20030396-1	2010	Bovine rhodopsin contains 11-cis-retinal as a light-absorbing chromophore that binds to a lysine residue of the apoprotein opsin via a protonated Schiff base linkage.	Lysine	90-96	rhodopsin	Bos taurus	7-16
2108161-2	1990	The biosynthesis of deoxyhypusine (N-(4-aminobutyl)lysine) occurs by the transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in a precursor of eukaryotic translation initiation factor 4D (eIF-4D).	Lysine	51-57	eukaryotic translation initiation factor 5A	Rattus norvegicus	215-221
28497125-4	2016	Here we map lysine 372 as the primary attachment site for ubiquitin on S. cerevisiae Mcm10.	Lysine	12-18	Mcm10p	Saccharomyces cerevisiae S288C	85-90
2106160-0	1990	Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation.	Lysine	50-57	histone H4	Saccharomyces cerevisiae S288C	20-30
19914676-2	2010	While previous studies showed that the side chain acetyl group of L-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine N(epsilon)-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the alpha-carbon and the side chain acetamido group, with that found in L-AcK being optimal.	Lysine	148-154	tyrosine kinase non receptor 2	Homo sapiens	68-71
19914676-2	2010	While previous studies showed that the side chain acetyl group of L-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine N(epsilon)-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the alpha-carbon and the side chain acetamido group, with that found in L-AcK being optimal.	Lysine	148-154	sirtuin 2	Homo sapiens	115-119
19914676-2	2010	While previous studies showed that the side chain acetyl group of L-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine N(epsilon)-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the alpha-carbon and the side chain acetamido group, with that found in L-AcK being optimal.	Lysine	148-154	tyrosine kinase non receptor 2	Homo sapiens	392-395
27392443-1	2016	PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas.	Lysine	56-62	H3.3 histone A	Homo sapiens	17-21
27392443-1	2016	PURPOSE: Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas.	Lysine	56-62	H3.3 histone A	Homo sapiens	23-28
2303410-10	1990	In contrast, pro-NPY(-Arg-Lys-) was cleaved at a much lower rate, and pro-NPY (-Lys-Lys-) was cleaved very poorly.	Lysine	26-29	neuropeptide Y	Mus musculus	13-20
2303410-10	1990	In contrast, pro-NPY(-Arg-Lys-) was cleaved at a much lower rate, and pro-NPY (-Lys-Lys-) was cleaved very poorly.	Lysine	80-83	neuropeptide Y	Mus musculus	70-77
19805576-3	2010	Here, we used immunoblotting and EGFP fusion protein fluorescence to demonstrate that murine nucleoplasmin 2 (NPM2) is a component of mouse NLBs and that the targeting of NPM2 to NLBs is regulated by a lysine-rich, 16-aa C-terminal motif (K-rich motif).	Lysine	202-208	nucleophosmin/nucleoplasmin 2	Mus musculus	93-108
19805576-3	2010	Here, we used immunoblotting and EGFP fusion protein fluorescence to demonstrate that murine nucleoplasmin 2 (NPM2) is a component of mouse NLBs and that the targeting of NPM2 to NLBs is regulated by a lysine-rich, 16-aa C-terminal motif (K-rich motif).	Lysine	202-208	nucleophosmin/nucleoplasmin 2	Mus musculus	110-114
2303410-10	1990	In contrast, pro-NPY(-Arg-Lys-) was cleaved at a much lower rate, and pro-NPY (-Lys-Lys-) was cleaved very poorly.	Lysine	80-83	neuropeptide Y	Mus musculus	70-77
19805576-3	2010	Here, we used immunoblotting and EGFP fusion protein fluorescence to demonstrate that murine nucleoplasmin 2 (NPM2) is a component of mouse NLBs and that the targeting of NPM2 to NLBs is regulated by a lysine-rich, 16-aa C-terminal motif (K-rich motif).	Lysine	202-208	nucleophosmin/nucleoplasmin 2	Mus musculus	171-175
2303410-12	1990	While two of the three mutant pro-NPY molecules were processed to wild-type carboxyl-terminal peptide, the carboxyl-terminal peptide derived from pro-NPY(-Arg-Lys-) contained an amino-terminal lysine residue, indicating that biosynthetic endoproteolysis occurred in the middle or at the amino terminus of the pair of basic amino acid residues at the cleavage site.	Lysine	159-162	neuropeptide Y	Mus musculus	146-153
2303410-12	1990	While two of the three mutant pro-NPY molecules were processed to wild-type carboxyl-terminal peptide, the carboxyl-terminal peptide derived from pro-NPY(-Arg-Lys-) contained an amino-terminal lysine residue, indicating that biosynthetic endoproteolysis occurred in the middle or at the amino terminus of the pair of basic amino acid residues at the cleavage site.	Lysine	193-199	neuropeptide Y	Mus musculus	146-153
2105216-5	1990	Comparison of the amino acid composition of beta-galactosidase from S. solfataricus with that from Escherichia coli revealed a lower cysteine content and a lower Arg/Lys ratio in the thermophilic enzyme.	Lysine	166-169	MFS transporter	Saccharolobus solfataricus	44-62
19948887-4	2010	Here, we show that this suppression of spt5 can result from loss of histone H3 lysines 4 or 36 methylation, or reduced recruitment of Chd1 or the Rpd3S complex.	Lysine	79-86	transcription elongation factor SPT5	Saccharomyces cerevisiae S288C	39-43
19948887-8	2010	We suggest that, as previously proposed for H3 lysine 36 methylation and the Rpd3S complex, H3 lysine 4 methylation and Chd1 function to maintain normal chromatin structures over transcribed genes, and that one function of Spt4-Spt5 is to help RNA polymerase II overcome the repressive effects of these histone modifications and chromatin regulators on transcription.	Lysine	95-101	transcription elongation factor SPT4	Saccharomyces cerevisiae S288C	223-227
27658392-4	2016	We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to the consensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked polyubiquitination, predominantly at the lysine 100 residue.	Lysine	199-205	patatin-like phospholipase domain containing 2	Mus musculus	95-99
27819666-4	2016	The sequence-specific readers recognize both the cis element (termed the cold memory element) and a repressive mark, trimethylation of histone H3 at lysine 27 (H3K27me3), and directly associate with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), leading to establishment of the H3K27me3 peak in the nucleation region at FLC during vernalization.	Lysine	149-155	like heterochromatin protein (LHP1)	Arabidopsis thaliana	199-229
27819666-4	2016	The sequence-specific readers recognize both the cis element (termed the cold memory element) and a repressive mark, trimethylation of histone H3 at lysine 27 (H3K27me3), and directly associate with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), leading to establishment of the H3K27me3 peak in the nucleation region at FLC during vernalization.	Lysine	149-155	like heterochromatin protein (LHP1)	Arabidopsis thaliana	231-235
20093773-4	2010	Here we have demonstrated that c-Myb is recruited to the MLL histone methyl transferase complex by menin, a protein important for MLL-associated leukemic transformation, and that it contributes substantially to MLL-mediated methylation of histone H3 at lysine 4 (H3K4).	Lysine	253-259	MYB proto-oncogene, transcription factor	Homo sapiens	31-36
2140680-1	1990	Modifications to the commonly employed lysine Sepharose affinity chromatography method for the purification of plasminogen from human plasma, give a preparation of native, Glu-plasminogen which is free of plasmin contamination.	Lysine	39-45	plasminogen	Homo sapiens	111-118
20093773-4	2010	Here we have demonstrated that c-Myb is recruited to the MLL histone methyl transferase complex by menin, a protein important for MLL-associated leukemic transformation, and that it contributes substantially to MLL-mediated methylation of histone H3 at lysine 4 (H3K4).	Lysine	253-259	lysine methyltransferase 2A	Homo sapiens	57-60
27803189-6	2016	Mutations in BRM not only increased occupancy of the -2 and +1 nucleosomes proximal to the transcription start site at the MIR156A locus but also the levels of trimethylated histone H3 at Lys 27.	Lysine	188-191	transcription regulatory protein SNF2	Arabidopsis thaliana	13-16
32797353-1	2021	RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized.	Lysine	70-76	ring finger protein 20	Mus musculus	0-5
27703003-3	2016	Our present studies show that SNIP1 is covalently modified by small ubiquitin-like modifier (SUMO) in vitro and in vivo at three lysine sites: Lys5, Lys30, and Lys108, with Lys30 being the major SUMO modification site.	Lysine	129-135	Smad nuclear interacting protein 1	Homo sapiens	30-35
19948738-7	2010	Thus, Lys(842) is critical for the known functions of the AI and also enables two additional functions of the AI as newly identified here: suppression of electron transfer to FMN and control of the conformational equilibrium of the nNOS reductase domain.	Lysine	6-9	formin 1	Homo sapiens	175-178
20028034-2	2010	The CI-MPR is a receptor for plasminogen, and this interaction can be inhibited by lysine analogues.	Lysine	83-89	insulin like growth factor 2 receptor	Homo sapiens	4-10
20028034-7	2010	To identify the lysine residue(s) of the CI-MPR that serve(s) as an essential determinant for recognition by the LBS of plasminogen, site-directed mutagenesis studies were carried out using a construct encoding the N-terminal three domains of the CI-MPR (Dom1-3His) which contains both a mannose 6-phosphate (Man-6-P) and plasminogen binding site.	Lysine	16-22	insulin like growth factor 2 receptor	Homo sapiens	41-47
20028034-8	2010	The results demonstrate two lysine residues (Lys53 located in domain 1 and Lys125 located in the loop connecting domains 1 and 2) of the CI-MPR are key determinants for plasminogen binding but are not required for Man-6-P binding.	Lysine	28-34	insulin like growth factor 2 receptor	Homo sapiens	137-143
27811920-0	2016	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres.	Lysine	26-32	centromere protein A	Gallus gallus	58-64
33793815-6	2021	Our results also indicate that Arabidopsis GCN5 acetylates multiple lysine residues on H3.1 variants, but H3.1K27 and H3.1K36 play essential functions in inducing genomic instability in the absence of H3.1K27me1.	Lysine	68-74	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	43-47
19923226-4	2010	Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79 and resulted in significant sensitivity to 6-azauracil and mycophenolic acid.	Lysine	62-68	H2B clustered histone 21	Homo sapiens	55-58
19923226-4	2010	Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79 and resulted in significant sensitivity to 6-azauracil and mycophenolic acid.	Lysine	95-102	H2B clustered histone 21	Homo sapiens	55-58
33821277-3	2021	The structure shows a highly basic and concave surface flanking the active site, comprising several Lys residues of nsp14 and the N-terminal amino group of nsp10.	Lysine	100-103	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	156-161
20023629-5	2010	USP9X binds MCL1 and removes the Lys 48-linked polyubiquitin chains that normally mark MCL1 for proteasomal degradation.	Lysine	33-36	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	87-91
27808254-0	2016	alpha-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.	Lysine	36-42	synuclein alpha	Homo sapiens	0-15
27542907-0	2016	TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.	Lysine	16-22	TSC complex subunit 2	Mus musculus	0-4
27542907-3	2016	This study analyzes tuberous sclerosis complex (TSC2) lysine acetylation, in the regulation of mTORC1 signaling activation, autophagy and cell proliferation.	Lysine	54-60	TSC complex subunit 2	Mus musculus	48-52
27542907-12	2016	This study provides, for the first time, a relationship between TSC2 lysine acetylation status and its stability, representing a novel mechanism for regulating mTORC1 pathway.	Lysine	69-75	TSC complex subunit 2	Mus musculus	64-68
20006587-4	2010	Deletion of a short lysine-rich domain that contains the major SUMO acceptor sites of CBP abrogated its ability to be SUMO modified, and prevented its association with endogenous SUMO-1/PML speckles in vivo.	Lysine	20-26	PML nuclear body scaffold	Homo sapiens	186-189
33232890-2	2021	PRC2 comprises a trimeric core of SUZ12, EED and EZH1/2, which together with RBBP4/7 is sufficient to catalyse mono-methylation, di-methylation and tri-methylation of histone H3 at lysine 27 (H3K27me1/2/3).	Lysine	181-187	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	34-39
19921743-0	2010	Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.	Lysine	15-21	cortactin	Mus musculus	53-62
19921743-6	2010	Especially effective in promoting the peptide binding is a Lys residue at the -5 position, a determinant present in both P2 (HPK1 394-403) and S1 (Shank2 1168-1189) peptides.	Lysine	59-62	mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus	125-129
27611768-0	2016	A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.	Lysine	44-50	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	74-80
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Lysine	18-21	interleukin 4	Mus musculus	132-136
33232890-2	2021	PRC2 comprises a trimeric core of SUZ12, EED and EZH1/2, which together with RBBP4/7 is sufficient to catalyse mono-methylation, di-methylation and tri-methylation of histone H3 at lysine 27 (H3K27me1/2/3).	Lysine	181-187	enhancer of zeste 1 polycomb repressive complex 2 subunit	Homo sapiens	49-55
33588715-5	2021	PSAT1 exists as a functional dimer, where each protomer has a large and a small domain; each large domain contains a Lys residue that covalently binds PLP.	Lysine	117-120	phosphoserine aminotransferase 1	Homo sapiens	0-5
27464357-3	2016	We identified the antigen molecule for 9F5: the 50- to 70-kDa fragments of rat glycoprotein nonmetastatic melanoma protein B (GPNMB)/osteoactivin, which started at Lys(170) .	Lysine	164-167	glycoprotein nmb	Rattus norvegicus	79-124
27464357-3	2016	We identified the antigen molecule for 9F5: the 50- to 70-kDa fragments of rat glycoprotein nonmetastatic melanoma protein B (GPNMB)/osteoactivin, which started at Lys(170) .	Lysine	164-167	glycoprotein nmb	Rattus norvegicus	126-131
27464357-3	2016	We identified the antigen molecule for 9F5: the 50- to 70-kDa fragments of rat glycoprotein nonmetastatic melanoma protein B (GPNMB)/osteoactivin, which started at Lys(170) .	Lysine	164-167	glycoprotein nmb	Rattus norvegicus	133-145
20386582-0	2010	[Role of individual lysine residues of horse cytochrome c in the formation of reactive complexes with components of the respiratory chain].	Lysine	20-26	cytochrome c, somatic	Equus caballus	45-57
19897479-1	2010	In Saccharomyces cerevisiae, lysine 4 on histone H3 (H3K4) is methylated by the Set1 complex (Set1C or COMPASS).	Lysine	29-35	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	80-84
27594515-2	2016	We recently identified SETD2 as a dual-function histone and microtubule methyltransferase, and methylation as a new microtubule PTM that occurs on lysine 40 of alpha-tubulin, which is trimethylated (alpha-TubK40me3) by SETD2.	Lysine	147-153	tubulin alpha 1b	Homo sapiens	160-173
17433364-3	2007	In human and Drosophila, CHD1 double chromodomains bind lysine 4-methylated histone H3 tail, which is a hallmark of transcriptionally active chromatin in all eukaryotes.	Lysine	56-62	Chromodomain-helicase-DNA-binding protein 1	Drosophila melanogaster	25-29
30023485-9	2016	Our models and binding data suggest that the aromatic cages of Cbx7/Cbx4 can accommodate larger alkyl groups such as diisobutyl substitution on the lysine nitrogen.	Lysine	148-154	chromobox 7	Homo sapiens	63-67
30023485-9	2016	Our models and binding data suggest that the aromatic cages of Cbx7/Cbx4 can accommodate larger alkyl groups such as diisobutyl substitution on the lysine nitrogen.	Lysine	148-154	chromobox 4	Homo sapiens	68-72
19755569-7	2010	The concentrations of lysine, phenylalanine, leucine, and aspartic acid were all significantly lower in concentration in the aap6 mutant plants compared with wild-type plants.	Lysine	22-28	amino acid permease 6	Arabidopsis thaliana	125-129
19875446-7	2009	Site-directed mutagenesis of GLYT2 EL4 residues was used to identify the key residues Arg(531), Lys(532), and Ile(545) that contribute to the differences in NAGly sensitivity.	Lysine	96-99	solute carrier family 6 member 5	Rattus norvegicus	29-34
19880507-3	2009	Here, we identified human SHIP2 monoubiquitination on lysine 315.	Lysine	54-60	inositol polyphosphate phosphatase like 1	Homo sapiens	26-31
17433364-8	2007	Despite great sequence similarity between the human CHD1 and CHD2 chromodomains, variation within an insert likely prevents CHD2 double chromodomains from binding lysine 4-methylated histone H3 tail as efficiently as in CHD1.	Lysine	163-169	chromodomain helicase DNA binding protein 1	Homo sapiens	52-56
17433364-8	2007	Despite great sequence similarity between the human CHD1 and CHD2 chromodomains, variation within an insert likely prevents CHD2 double chromodomains from binding lysine 4-methylated histone H3 tail as efficiently as in CHD1.	Lysine	163-169	chromodomain helicase DNA binding protein 1	Homo sapiens	220-224
34728328-9	2022	The sod1  mutant is known to exhibit methionine and lysine auxotrophy.	Lysine	52-58	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	4-8
19877718-5	2009	Replacement of a central Gly in the neuromodulin IQ domain with a Lys at this position in PEP19 almost entirely accounts for the distinctive patterns of Ca(2+)-dependent stability changes exhibited by the two complexes.	Lysine	66-69	growth associated protein 43	Homo sapiens	36-48
19877718-6	2009	Replacement of a Lys immediately before the "IQ" amino acid pair in the neuromodulin sequence with the Ala in PEP19 accounts for the remaining Ca(2+)-dependent differences.	Lysine	17-20	growth associated protein 43	Homo sapiens	72-84
19955365-4	2009	Here, we show that mutating lysine 257 (K257), an amino acid adjacent to the caspase-7 cleavage site of ataxin-7 regulates turnover of the truncation product in a repeat-dependent manner.	Lysine	28-34	caspase 7	Homo sapiens	77-86
27783945-5	2016	We show that SIRT2 deacetylates Slug protein at lysine residue K116 to prevent Slug degradation.	Lysine	48-54	sirtuin 2	Homo sapiens	13-18
34826399-5	2022	Chromatin immunoprecipitation analysis revealed that lysine demethylase 3A (KDM3A) expression was transcriptionally activated by HIF-3alpha under hypoxia, and KDM3A occupied the SRY-box transcription factor 9 (SOX9) gene promoter region through H3 lysine 9 dimethylation (H3K9me2).	Lysine	248-254	SRY-box transcription factor 9	Homo sapiens	210-214
26989081-0	2016	Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.	Lysine	74-80	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	0-18
26989081-5	2016	When CpD mRNA levels were reduced by RNAi (RNA interference) technology, C-terminal lysine levels increased, whereas there was no obvious change in C-terminal lysine levels when a different carboxypeptidase mRNA level was knocked down suggesting that carboxypeptidase D is the main contributor for C-terminal lysine processing.	Lysine	84-90	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	5-8
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	147-153	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	23-26
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	147-153	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
20025521-9	2009	Other epigenetic modifications including histone 3 lysine 4, 9, and 27 trimethylation (H3K4me3, H3K9me3, and H3K27me3) showed similar patterns around the regulatory regions of Oct4 and Nanog in both kinds of ES cells.	Lysine	51-57	POU class 5 homeobox 1	Homo sapiens	176-180
19843608-5	2009	Chromatin immunoprecipitation revealed that trimethylated histone H3 lysine 9 and H4 lysine 20 were enriched in the last exon through the proximal downstream region of RBM10, but were remarkably diminished at approximately 2 kb upstream of the UBA1 transcription start site.	Lysine	69-75	RNA binding motif protein 10	Homo sapiens	168-173
19843608-5	2009	Chromatin immunoprecipitation revealed that trimethylated histone H3 lysine 9 and H4 lysine 20 were enriched in the last exon through the proximal downstream region of RBM10, but were remarkably diminished at approximately 2 kb upstream of the UBA1 transcription start site.	Lysine	69-75	ubiquitin like modifier activating enzyme 1	Homo sapiens	244-248
19843608-5	2009	Chromatin immunoprecipitation revealed that trimethylated histone H3 lysine 9 and H4 lysine 20 were enriched in the last exon through the proximal downstream region of RBM10, but were remarkably diminished at approximately 2 kb upstream of the UBA1 transcription start site.	Lysine	85-91	RNA binding motif protein 10	Homo sapiens	168-173
19843608-5	2009	Chromatin immunoprecipitation revealed that trimethylated histone H3 lysine 9 and H4 lysine 20 were enriched in the last exon through the proximal downstream region of RBM10, but were remarkably diminished at approximately 2 kb upstream of the UBA1 transcription start site.	Lysine	85-91	ubiquitin like modifier activating enzyme 1	Homo sapiens	244-248
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	147-153	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	355-361	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	23-26
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	355-361	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
34808502-10	2021	The silencing of KAT6A reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) and RNA polymerase II (RNA pol II) on the promoter of YAP in sorafenib-resistant HCC cells.	Lysine	60-66	Yes1 associated transcriptional regulator	Homo sapiens	146-149
26989081-6	2016	Most importantly, when CpD expression was knocked out by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology, C-terminal lysine cleavage was completely abolished in CpD knockout cells based on mass spectrometry analysis, demonstrating that CpD is the only endogenous carboxypeptidase that cleaves antibody heavy chain C-terminal lysine in CHO cells.	Lysine	355-361	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	191-194
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	Lysine	95-101	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	128-146
26989081-7	2016	Hence, our work showed for the first time that the cleavage of antibody heavy chain C-terminal lysine is solely mediated by the carboxypeptidase D in CHO cells and our finding provides one solution to eliminating C-terminal lysine heterogeneity for therapeutic antibody production by knocking out CpD gene expression.	Lysine	95-101	LOW QUALITY PROTEIN: carboxypeptidase D	Cricetulus griseus	297-300
19864627-3	2009	Here, we report a novel mechanism of NF-kappaB regulation through lysine monomethylation by SET9 methyltransferase.	Lysine	66-72	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	92-96
19864627-4	2009	Set9 specifically methylates p65 at lysine 37.	Lysine	36-42	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
19744929-10	2009	Furthermore, hNaa50p autoacetylates lysines 34, 37, and 140 in vitro, modulating hNaa50p substrate specificity.	Lysine	36-43	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	13-20
19744929-10	2009	Furthermore, hNaa50p autoacetylates lysines 34, 37, and 140 in vitro, modulating hNaa50p substrate specificity.	Lysine	36-43	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	81-88
19922872-1	2009	We report that embryos deficient in the histone acetyltransferase Moz (Myst3/Kat6a) show histone H3 lysine 9 (H3K9) hypoacetylation, corresponding H3K9 hypermethylation, and reduced transcription at Hox gene loci.	Lysine	100-106	K(lysine) acetyltransferase 6A	Mus musculus	66-69
19922872-1	2009	We report that embryos deficient in the histone acetyltransferase Moz (Myst3/Kat6a) show histone H3 lysine 9 (H3K9) hypoacetylation, corresponding H3K9 hypermethylation, and reduced transcription at Hox gene loci.	Lysine	100-106	K(lysine) acetyltransferase 6A	Mus musculus	71-76
34914972-11	2022	These observations show for the first time that IP-10 mRNA stability is dynamically regulated by Lysine demethylation of hnRNPK by LSD-1.	Lysine	97-103	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	121-127
19922872-1	2009	We report that embryos deficient in the histone acetyltransferase Moz (Myst3/Kat6a) show histone H3 lysine 9 (H3K9) hypoacetylation, corresponding H3K9 hypermethylation, and reduced transcription at Hox gene loci.	Lysine	100-106	K(lysine) acetyltransferase 6A	Mus musculus	77-82
27358110-3	2016	Here, deacetylation of the Stat5a coactivator and chromatin-remodeling protein HMGN2 on lysine residue K2 by HDAC6 promotes Stat5a-mediated transcription and breast cancer growth.	Lysine	88-94	signal transducer and activator of transcription 5A	Homo sapiens	27-33
27358110-3	2016	Here, deacetylation of the Stat5a coactivator and chromatin-remodeling protein HMGN2 on lysine residue K2 by HDAC6 promotes Stat5a-mediated transcription and breast cancer growth.	Lysine	88-94	signal transducer and activator of transcription 5A	Homo sapiens	124-130
19567367-1	2009	Heterochromatin protein 1 (HP1) family members (alpha, beta, and gamma) bind histone H3 methylated at Lys-9, leading to gene silencing and heterochromatin formation.	Lysine	102-105	chromobox 5	Homo sapiens	0-25
19567367-1	2009	Heterochromatin protein 1 (HP1) family members (alpha, beta, and gamma) bind histone H3 methylated at Lys-9, leading to gene silencing and heterochromatin formation.	Lysine	102-105	chromobox 5	Homo sapiens	27-30
34788845-3	2021	Here we report that loss of HAT1, which acetylates lysines 5 and 12 of newly synthesized histone H4 during replication-coupled chromatin assembly, results in the loss of accessibility of large domains of heterochromatin, termed HAT1-dependent Accessibility Domains (HADs).	Lysine	51-58	histone aminotransferase 1	Mus musculus	28-32
27419650-1	2016	We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls.	Lysine	156-162	lysine methyltransferase 2A	Homo sapiens	36-60
19788305-2	2009	A prototype example is the trimethylation (Me3) of lysine 9 on histone 3 (H3), which is a readout by an aromatic cage of the chromodomain of heterochromatin-associated protein 1 (HP1) thereby leading to transcriptional repression and heterochromatin formation.	Lysine	51-57	chromobox 5	Homo sapiens	141-177
34788845-3	2021	Here we report that loss of HAT1, which acetylates lysines 5 and 12 of newly synthesized histone H4 during replication-coupled chromatin assembly, results in the loss of accessibility of large domains of heterochromatin, termed HAT1-dependent Accessibility Domains (HADs).	Lysine	51-58	histone aminotransferase 1	Mus musculus	228-232
19788305-2	2009	A prototype example is the trimethylation (Me3) of lysine 9 on histone 3 (H3), which is a readout by an aromatic cage of the chromodomain of heterochromatin-associated protein 1 (HP1) thereby leading to transcriptional repression and heterochromatin formation.	Lysine	51-57	chromobox 5	Homo sapiens	179-182
19788305-6	2009	Meanwhile, our calculated free energy difference between H3-tert-butyl norleucine 9 and H3-methylnorleucine 9 in their binding to the HP1 clearly reveals the importance of the charge independent interactions for the state-specific readout of histone lysine trimethylation marks.	Lysine	250-256	chromobox 5	Homo sapiens	134-137
34842492-4	2021	Lysine Acetyltransferase 6 A (KAT6A) is a protein coding gene and plays a critical role in many cellular processes.	Lysine	0-6	histone acetyltransferase KAT6A	Ovis aries	30-35
20723346-9	2009	And the polymorphisms of XPD codon 751 were also associated with increased lung cancer risk (Lys/Gln OR=1.09, 95%CI: 1.02-1.18; Gln/Gln OR=1.24, 95%CI: 1.10-1.41).	Lysine	93-96	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
27486774-1	2016	Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory and DNA damage response pathways.	Lysine	101-107	ubiquitin conjugating enzyme E2 N	Homo sapiens	0-5
27653692-4	2016	KAT6A-deficient CD8(+) T cells downregulated surface CD8 co-receptor expression during clonal expansion, a finding linked to reduced Cd8alpha transcripts and histone-H3 lysine 9 acetylation of the Cd8 locus.	Lysine	169-175	lysine acetyltransferase 6A	Homo sapiens	0-5
34837535-7	2021	Additionally, we confirmed that RNF166 interacts with and forms lysine 63-linked polyubiquitin chains in Ku80.	Lysine	64-70	X-ray repair cross complementing 5	Homo sapiens	105-109
27466423-11	2016	We also developed a monoclonal antibody specifically targeting the region of NTCP centered on lysine residue 86, and it can differentiate the modified mouse NTCP from that of the wild type and partially inhibited HDV infection.	Lysine	94-100	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	77-81
19767730-2	2009	The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED.	Lysine	111-117	Su(z)12	Drosophila melanogaster	240-245
27466423-11	2016	We also developed a monoclonal antibody specifically targeting the region of NTCP centered on lysine residue 86, and it can differentiate the modified mouse NTCP from that of the wild type and partially inhibited HDV infection.	Lysine	94-100	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	157-161
19812315-9	2009	Additionally, we demonstrate that plasminogen specifically bound to laminin-1, the interaction resulted in increased plasminogen activation by tissue-type plasminogen activator, and was dependent on a functional lysine binding site within plasminogen kringle 5.	Lysine	212-218	laminin subunit alpha 1	Rattus norvegicus	68-77
34570618-2	2021	Modifications of histone H2A N-terminal tail has also been linked to DNA damage response, through acetylation or ubiquitination of lysine residues that regulate repair pathway choice.	Lysine	131-137	histone H2A	Saccharomyces cerevisiae S288C	17-28
19651786-2	2009	From the proteinase K-cleavable peripheral fraction of Lewy bodies, which was densely cross-linked by gamma-glutamyl-epsilon-lysine bonds between HspB1 and ubiquitin in a pattern similar to neurofibrillary tangles (Nemes, Z., Devreese, B., Steinert, P. M., Van Beeumen, J., and Fesus, L. (2004) FASEB J.	Lysine	125-131	heat shock protein family B (small) member 1	Homo sapiens	146-151
34834120-1	2021	In our previous paper, we reported that amphiphilic Ir complex-peptide hybrids (IPHs) containing basic peptides such as KK(K)GG (K: lysine, G: glycine) (e.g., ASb-2) exhibited potent anticancer activity against Jurkat cells, with the dead cells showing a strong green emission.	Lysine	132-138	ankyrin repeat and SOCS box containing 2	Homo sapiens	159-164
19829087-5	2009	Set9 was initially found to target histone H3 lysine 4 for monomethylation and was subsequently shown to target a variety of non-histone proteins, especially transcription-related factors.	Lysine	46-52	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
19829087-7	2009	Here we summarize the latest findings on the effects of Set9-mediated lysine methylation on the stability of non-histone proteins.	Lysine	70-76	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	56-60
27353379-0	2016	The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.	Lysine	4-10	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	31-35
27353379-2	2016	The iron-sulfur cluster-containing enzyme homoaconitase converts homocitrate to homoisocitrate in the lysine biosynthetic pathway, and is encoded by LYS4 in the model yeast Saccharomyces cerevisiae.	Lysine	102-108	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	149-153
27353379-4	2016	Deletion of the LYS4 gene resulted in lysine auxotrophy suggesting that Lys4 is essential for lysine biosynthesis.	Lysine	38-44	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	16-20
27353379-4	2016	Deletion of the LYS4 gene resulted in lysine auxotrophy suggesting that Lys4 is essential for lysine biosynthesis.	Lysine	94-100	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	16-20
27353379-4	2016	Deletion of the LYS4 gene resulted in lysine auxotrophy suggesting that Lys4 is essential for lysine biosynthesis.	Lysine	94-100	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	72-76
34804916-1	2021	Neddylation is a process in which a ubiquitin-like molecule NEDD8 is conjugated to a lysine residue of the substrate protein via successive enzymatic cascade reactions.	Lysine	85-91	NEDD8 ubiquitin like modifier	Homo sapiens	60-65
27346274-9	2016	Mutagenesis of each amino acid difference in EC1 between BB3 receptor/BB2 receptor showed replacement of His(107) in BB3 receptor by Lys(107) (H107K-BB3 receptor-mutant) from BB2 receptor, decreased affinity 60-fold, and three replacements [H107K, E11D, G112R] decreased affinity 500-fold.	Lysine	133-136	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	45-48
19762820-0	2009	Meta-analysis of milk protein yield responses to lysine and methionine supplementation.	Lysine	49-55	PY	Bos taurus	17-35
19762820-2	2009	The objective of this study was to quantify the milk protein yield (MPY; g/d) response in studies in which Met or Lys was supplied either by postruminal infusion or in a rumen-protected form.	Lysine	114-117	PY	Bos taurus	48-66
19752231-8	2009	A central pocket binds arginine 83, the only Bw4 motif residue essential for KIR3DL1 interaction, similar to the binding of lysine 80 in HLA-C by KIR2DL1.	Lysine	124-130	body weight QTL 4	Mus musculus	45-48
34725333-7	2021	Mechanistic study further indicated that SIRT6 directly binds to mini-chromosome and deacetylates histone H3 lysine 9 (H3K9ac) and histone H3 lysine 56 (H3K56ac), and chemical activation of endogenous SIRT6 with MDL800 suppressed HBV infection in vitro and in vivo.	Lysine	109-115	sirtuin 6	Homo sapiens	41-46
34725333-7	2021	Mechanistic study further indicated that SIRT6 directly binds to mini-chromosome and deacetylates histone H3 lysine 9 (H3K9ac) and histone H3 lysine 56 (H3K56ac), and chemical activation of endogenous SIRT6 with MDL800 suppressed HBV infection in vitro and in vivo.	Lysine	142-148	sirtuin 6	Homo sapiens	41-46
27384303-8	2016	Manipulations of tet2 expression altered tet2 genome binding and histone 3 lysine 4 trimethylation abundance at the GnRH promoter.	Lysine	75-81	tet methylcytosine dioxygenase 2	Mus musculus	17-21
27384303-8	2016	Manipulations of tet2 expression altered tet2 genome binding and histone 3 lysine 4 trimethylation abundance at the GnRH promoter.	Lysine	75-81	gonadotropin releasing hormone 1	Mus musculus	116-120
34347311-9	2021	The Ac-SDpsiKP analogue (whereby the peptide bond between the aspartate and lysine is reduced) peptide inhibited TGF-beta/ small mother against decapentaplegic (Smad)-3 signalling and collagen deposition.	Lysine	76-82	transforming growth factor alpha	Homo sapiens	113-121
27402839-5	2016	Studies on the interaction of the RAP third domain with LRP1 reveal critical contributions by lysine 256 and lysine 270 for this interaction.	Lysine	109-115	LDL receptor related protein associated protein 1	Homo sapiens	34-37
27405757-0	2016	Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.	Lysine	81-87	phosphatase and tensin homolog	Homo sapiens	12-16
19589362-9	2009	The changes in ratios of CCK9 compared to CCK8 are consistent with dual roles of the cathepsin L protease pathway that includes aminopeptidase B to remove NH2-terminal Arg or Lys, and the PC1/3 protease pathway.	Lysine	175-178	cathepsin L	Mus musculus	85-96
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Lysine	97-103	estrogen receptor 1 (alpha)	Mus musculus	36-59
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Lysine	97-103	estrogen receptor 1 (alpha)	Mus musculus	61-68
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Lysine	97-103	estrogen receptor 1 (alpha)	Mus musculus	281-288
27405757-5	2016	The present work identifies a key role for Lys(66) in the regulation of PTEN expression and provides both an opportunity to improve the stability of PTEN as a protein therapy and a mechanistic basis for efforts to stabilize endogenous PTEN.	Lysine	43-46	phosphatase and tensin homolog	Homo sapiens	72-76
34347311-9	2021	The Ac-SDpsiKP analogue (whereby the peptide bond between the aspartate and lysine is reduced) peptide inhibited TGF-beta/ small mother against decapentaplegic (Smad)-3 signalling and collagen deposition.	Lysine	76-82	SMAD family member 3	Homo sapiens	123-168
27563873-8	2016	In complementary ubiquitination assays, we show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain.	Lysine	109-115	cell division cycle 25C	Homo sapiens	83-89
19650668-2	2009	Cytochrome c exhibits two positively charged sites: site A containing lysine residues with high pKa values and site L containing ionizable groups with pKaobs values around 7.0.	Lysine	70-76	cytochrome c, somatic	Equus caballus	0-12
34397151-0	2021	Calcitonin gene-related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain.	Lysine	55-61	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
19556245-0	2009	On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.	Lysine	29-35	lysine methyltransferase 2A	Homo sapiens	61-93
19556245-0	2009	On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.	Lysine	29-35	lysine methyltransferase 2A	Homo sapiens	95-99
19556245-7	2009	Single turnover kinetic experiments reveal that the reaction leading to H3K4 dimethylation involves the transient accumulation of a monomethylated species, suggesting that the MLL1 core complex uses a non-processive mechanism to catalyze multiple lysine methylation.	Lysine	247-253	lysine methyltransferase 2A	Homo sapiens	176-180
27563873-8	2016	In complementary ubiquitination assays, we show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain.	Lysine	109-115	cell division cycle 25C	Homo sapiens	126-132
19556245-9	2009	Our results suggest that the mechanism of multiple lysine methylation by the MLL1 core complex involves the sequential addition of two methyl groups at two distinct active sites within the complex.	Lysine	51-57	lysine methyltransferase 2A	Homo sapiens	77-81
34671018-3	2021	Nuclear receptor-binding SET Domain protein 2 (NSD2) is a key histone methyltransferase catalyzing histone H3 lysine 36 dimethylation (H3K36me2).	Lysine	110-116	PR/SET domain 9	Homo sapiens	62-87
19630420-3	2009	Limited LysC proteolysis leads to high efficiency cleavage at the C-terminal side of the hinge lysine 222 residue, generating Fab and Fc fragments.	Lysine	95-101	FA complementation group B	Homo sapiens	126-129
19630420-5	2009	The growth of the Fab-Fc species was proportional to the duration and storage temperature of the incubation period and correlated with the amount of isomerization of the aspartic acid residue preceding lysine 222, determined by peptide mapping.	Lysine	202-208	FA complementation group B	Homo sapiens	18-21
27435297-3	2016	We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types.	Lysine	240-247	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog	Homo sapiens	19-24
27435297-3	2016	We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types.	Lysine	240-247	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	73-92
27435297-3	2016	We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types.	Lysine	240-247	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	94-97
27435297-3	2016	We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types.	Lysine	240-247	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	113-118
19453968-2	2009	The suppressor of cytokine signaling protein SOCS3 drives lysosomal degradation of the granulocyte colony-stimulating factor receptor (G-CSFR), depending on SOCS3-mediated ubiquitination of a specific lysine located in a conserved juxtamembrane motif.	Lysine	201-207	colony stimulating factor 3 receptor	Homo sapiens	87-133
19453968-2	2009	The suppressor of cytokine signaling protein SOCS3 drives lysosomal degradation of the granulocyte colony-stimulating factor receptor (G-CSFR), depending on SOCS3-mediated ubiquitination of a specific lysine located in a conserved juxtamembrane motif.	Lysine	201-207	colony stimulating factor 3 receptor	Homo sapiens	135-141
27435297-3	2016	We discovered that VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is essential for modification of lysines in multiple collagen types.	Lysine	240-247	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog	Homo sapiens	183-188
34534290-3	2021	Most of the mutations that suppressed extended HMR-silencing in rpd3 mutants without completely abolishing silencing were identified in the histone H3 lysine 4 methylation (H3K4me) pathway, specifically in SET1, BRE1 and BRE2.	Lysine	151-157	E3 ubiquitin-protein ligase BRE1	Saccharomyces cerevisiae S288C	212-216
26568301-6	2016	Knocking down USP24 increased Suv39h1 level through a decrease in mouse double-minute 2 homolog levels, thus enhancing lysine-9 methylation of histone H3, and resulting in the prevention of lung cancer malignancy.	Lysine	119-125	ubiquitin specific peptidase 24	Mus musculus	14-19
19494119-7	2009	However, displacement of the inhibitory MCL-1 protein from BAK is compromised when Lys-120 acetylation is blocked.	Lysine	83-86	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	40-45
34671716-0	2021	Global Histone H3 Lysine 4 Trimethylation (H3K4me3) Landscape Changes in Response to TGFbeta.	Lysine	18-24	transforming growth factor alpha	Homo sapiens	85-92
19407811-2	2009	We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250.	Lysine	72-78	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	19-24
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	122-126
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	pleckstrin	Homo sapiens	156-159
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	melanotransferrin	Homo sapiens	184-187
19443658-3	2009	The leukemogenic CALM-AF10 fusion protein is capable of interacting with the histone H3 lysine 79 (H3K79)-specific methyltransferase hDOT1L through the fused AF10 moiety.	Lysine	88-94	synaptosome associated protein 91	Homo sapiens	17-21
34671716-7	2021	In this report, we performed chromatin immunoprecipitation-sequencing (ChIP-Seq) to identify the genome-wide regions that undergo changes in histone H3 Lysine 4 trimethylation (H3K4me3) occupancy in response to TGFbeta stimulation.	Lysine	152-158	transforming growth factor alpha	Homo sapiens	211-218
19443658-3	2009	The leukemogenic CALM-AF10 fusion protein is capable of interacting with the histone H3 lysine 79 (H3K79)-specific methyltransferase hDOT1L through the fused AF10 moiety.	Lysine	88-94	MLLT10 histone lysine methyltransferase DOT1L cofactor	Homo sapiens	22-26
19443658-3	2009	The leukemogenic CALM-AF10 fusion protein is capable of interacting with the histone H3 lysine 79 (H3K79)-specific methyltransferase hDOT1L through the fused AF10 moiety.	Lysine	88-94	MLLT10 histone lysine methyltransferase DOT1L cofactor	Homo sapiens	158-162
34606826-2	2021	Zhang and colleagues provide new understanding of memory formation by uncovering the lysine acetyltransferase SRC3 as the key driver of the novel posttranslational modification of calmodulin (CaM) acetylation, which regulates CaM"s activity and subsequent activation of CaMKII.	Lysine	85-91	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	270-276
19553542-4	2009	Immunoblotting demonstrates that c-Maf can be modified at lysine 33 by SUMO-1 (small ubiquitin-like modifier 1).	Lysine	58-64	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	33-38
27383765-2	2016	Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation.	Lysine	95-101	microtubule associated protein tau	Homo sapiens	10-13
27383765-2	2016	Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation.	Lysine	95-101	microtubule associated protein tau	Homo sapiens	137-140
34599168-3	2021	SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127.	Lysine	75-81	keratin 27	Homo sapiens	14-17
27383765-3	2016	Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats.	Lysine	78-84	microtubule associated protein tau	Homo sapiens	26-29
27383765-3	2016	Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats.	Lysine	158-164	microtubule associated protein tau	Homo sapiens	26-29
27159579-1	2016	Bromodomain-containing proteins of the BET family recognize histone lysine acetylation and mediate transcriptional activation of target genes such as the MYC oncogene.	Lysine	68-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	154-157
19502796-5	2009	The transcriptional regulation of ribosomal RNA gene by mdig is achieved through abrogating tri-methyl lysine 9 on histone H3 and enhancing RNA polymerase I occupancy in the promoter region of the ribosomal RNA gene as demonstrated by chromatin immunoprecipitation.	Lysine	103-109	ribosomal oxygenase 2	Homo sapiens	56-60
19535349-8	2009	In particular, histone H3 specific methylation at lysine 79 catalyzed by DOT1L has been recognized as a hallmark of chromatin activated by MLL fusion proteins.	Lysine	50-56	lysine methyltransferase 2A	Homo sapiens	139-142
34584221-8	2022	Mechanistically, TRIM31 interacted with and catalyzed the K48-linked polyubiquitination of lysine 72 on Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), followed by the proteasomal degradation of MAP3K7, which further negatively regulated TGF-beta1-mediated Smad and MAPK/NF-kappaB signaling pathways.	Lysine	91-97	mitogen-activated protein kinase kinase kinase 7	Mus musculus	104-152
19465398-4	2009	Here, we demonstrate that HMGA1a/b and HMGA2 possess intrinsic dRP and AP site cleavage activities, and that lysines and arginines in the AT-hook DNA-binding domains function as nucleophiles.	Lysine	109-116	high mobility group AT-hook 1	Homo sapiens	26-32
19465398-4	2009	Here, we demonstrate that HMGA1a/b and HMGA2 possess intrinsic dRP and AP site cleavage activities, and that lysines and arginines in the AT-hook DNA-binding domains function as nucleophiles.	Lysine	109-116	high mobility group AT-hook 2	Homo sapiens	39-44
27354553-5	2016	SDG8 and SDG25 affected distinct and overlapping global and locus-specific histone H3 lysine 4 (H3K4) and histone H3 lysine 36 (H3K36) methylations.	Lysine	86-92	histone-lysine N-methyltransferase	Arabidopsis thaliana	0-4
27354553-5	2016	SDG8 and SDG25 affected distinct and overlapping global and locus-specific histone H3 lysine 4 (H3K4) and histone H3 lysine 36 (H3K36) methylations.	Lysine	117-123	histone-lysine N-methyltransferase	Arabidopsis thaliana	0-4
34584221-8	2022	Mechanistically, TRIM31 interacted with and catalyzed the K48-linked polyubiquitination of lysine 72 on Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), followed by the proteasomal degradation of MAP3K7, which further negatively regulated TGF-beta1-mediated Smad and MAPK/NF-kappaB signaling pathways.	Lysine	91-97	mitogen-activated protein kinase kinase kinase 7	Mus musculus	154-160
34602983-4	2021	The gene cylindromatosis (Cyld), which encodes a lysine-63 deubiquitinase, is expressed in several brain regions including the amygdala.	Lysine	49-55	CYLD lysine 63 deubiquitinase	Mus musculus	9-24
26779630-1	2016	SET7/9 is a protein lysine methyltransferase that had been initially identified as a histone lysine methyltransferase which generates monomethylation at histone 3 lysine 4.	Lysine	20-26	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
27259994-4	2016	Site-directed mutagenesis revealed that acetylation at lysine (K) 64 of LKB1 triggers the formation of SIRT1/HERC2/LKB1 protein complex and subsequent proteasomal degradation.	Lysine	55-61	serine/threonine kinase 11	Homo sapiens	72-76
27259994-4	2016	Site-directed mutagenesis revealed that acetylation at lysine (K) 64 of LKB1 triggers the formation of SIRT1/HERC2/LKB1 protein complex and subsequent proteasomal degradation.	Lysine	55-61	serine/threonine kinase 11	Homo sapiens	115-119
19544450-2	2009	The histone methyltransferase Dot1L is responsible for methylation of histone H3 at lysine 79 (H3K79me).	Lysine	84-90	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	30-35
19495417-10	2009	N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes.	Lysine	34-40	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
19495417-10	2009	N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes.	Lysine	34-40	LIF interleukin 6 family cytokine	Homo sapiens	76-79
34602983-4	2021	The gene cylindromatosis (Cyld), which encodes a lysine-63 deubiquitinase, is expressed in several brain regions including the amygdala.	Lysine	49-55	CYLD lysine 63 deubiquitinase	Mus musculus	26-30
27158766-0	2016	Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of alpha-Synuclein.	Lysine	83-90	synuclein alpha	Homo sapiens	94-109
34528302-9	2021	Our study shows that a certain proportion of lysine residue in diet affects the specific metabolic pathway of broilers, which may affect amino acid and fat metabolism by regulating alanine aminotransferase, aspartate aminotransferase and high-density lipoprotein cholesterol, ultimately affecting the flavour.	Lysine	45-51	glutamic--pyruvic transaminase	Homo sapiens	181-205
27248498-6	2016	In the current study we find that 1) protein degradation is initiated by K48-linked polyubiquitination of the lysine- 25 in G0S2; and 2) G0S2 protein is stabilized in response to ATGL expression and TG accumulation.	Lysine	110-116	G0/G1 switch gene 2	Mus musculus	124-128
27248498-6	2016	In the current study we find that 1) protein degradation is initiated by K48-linked polyubiquitination of the lysine- 25 in G0S2; and 2) G0S2 protein is stabilized in response to ATGL expression and TG accumulation.	Lysine	110-116	G0/G1 switch gene 2	Mus musculus	137-141
27248498-6	2016	In the current study we find that 1) protein degradation is initiated by K48-linked polyubiquitination of the lysine- 25 in G0S2; and 2) G0S2 protein is stabilized in response to ATGL expression and TG accumulation.	Lysine	110-116	patatin-like phospholipase domain containing 2	Mus musculus	179-183
27248498-7	2016	Mutation of lysine-25 of G0S2 abolished ubiquitination and increased protein stability.	Lysine	12-18	G0/G1 switch gene 2	Mus musculus	25-29
19380491-5	2009	MAVS is ubiquitinated following Sendai virus infection, and K63-linked ubiquitination of lysine 500 (K500) of MAVS mediates recruitment of IKKepsilon to the mitochondria.	Lysine	89-95	mitochondrial antiviral signaling protein	Homo sapiens	110-114
19380491-5	2009	MAVS is ubiquitinated following Sendai virus infection, and K63-linked ubiquitination of lysine 500 (K500) of MAVS mediates recruitment of IKKepsilon to the mitochondria.	Lysine	89-95	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	139-149
19321453-7	2009	Charge reversal of neighboring cationic groups in the TLR4 ectodomain (Lys-388 and Lys-435), in contrast, did not affect cell activation.	Lysine	71-74	toll like receptor 4	Homo sapiens	54-58
19321453-7	2009	Charge reversal of neighboring cationic groups in the TLR4 ectodomain (Lys-388 and Lys-435), in contrast, did not affect cell activation.	Lysine	83-86	toll like receptor 4	Homo sapiens	54-58
34497374-4	2021	In this study, we report that IFN-alpha2b enhances the histone deacetylase 3 (HDAC3)-mediated de-2-hydroxyisobutyrylation of histone H4 lysine 8 (H4K8) on HBV cccDNA minichromosome to restrict the cccDNA transcription in liver.	Lysine	136-142	interferon alpha 2	Homo sapiens	30-41
19413317-2	2009	Among the compounds thus designed and synthesized, we found that 2k, which contains an ethoxycarbonyl group at the alpha position to the acetamide of acetylated lysine substrate analogue 1, showed potent inhibitory activity in an in vitro assay using recombinant SIRT1, with high selectivity over SIRT2 and SIRT3.	Lysine	161-167	sirtuin 2	Homo sapiens	297-302
34497374-4	2021	In this study, we report that IFN-alpha2b enhances the histone deacetylase 3 (HDAC3)-mediated de-2-hydroxyisobutyrylation of histone H4 lysine 8 (H4K8) on HBV cccDNA minichromosome to restrict the cccDNA transcription in liver.	Lysine	136-142	histone deacetylase 3	Homo sapiens	55-76
34497374-4	2021	In this study, we report that IFN-alpha2b enhances the histone deacetylase 3 (HDAC3)-mediated de-2-hydroxyisobutyrylation of histone H4 lysine 8 (H4K8) on HBV cccDNA minichromosome to restrict the cccDNA transcription in liver.	Lysine	136-142	histone deacetylase 3	Homo sapiens	78-83
27021582-1	2016	SIRT1 is a key protein deacetylase that regulates cellular metabolism through lysine deacetylation on both histones and non-histone proteins.	Lysine	78-84	sirtuin 1	Mus musculus	0-5
34568085-4	2021	The K4 Kringle domain of the Plg molecule was required for binding of Plg to whole PbsP and to a PbsP fragment encompassing a region rich in methionine and lysine (MK-rich domain).	Lysine	156-162	plasminogen	Homo sapiens	29-32
26973343-0	2016	Regulation of HIF-1alpha stability by lysine methylation.	Lysine	38-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	14-24
19318352-3	2009	Through affinity purification of acetylated peptides and mass spectrometry, we identified that OTC is acetylated on lysine residues, including Lys88, which is also mutated in OTC-deficient patients.	Lysine	116-122	ornithine transcarbamylase	Homo sapiens	95-98
19152073-0	2009	Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification.	Lysine	27-30	BRCA1 associated protein	Homo sapiens	0-5
34568085-5	2021	These interactions were inhibited by free L-lysine, indicating the involvement of lysine binding sites in the Plg molecule.	Lysine	42-50	plasminogen	Homo sapiens	110-113
19152073-6	2009	Furthermore, we found that Brap2, which has intrinsic RING domain dependent E3 ligase activity, facilitates HsCdc14A Lys-63 linked ubiquitin modification, indicating that Brap2 may be the ubiquitin E3 Ligase of HsCdc14A.	Lysine	117-120	BRCA1 associated protein	Homo sapiens	27-32
19152073-6	2009	Furthermore, we found that Brap2, which has intrinsic RING domain dependent E3 ligase activity, facilitates HsCdc14A Lys-63 linked ubiquitin modification, indicating that Brap2 may be the ubiquitin E3 Ligase of HsCdc14A.	Lysine	117-120	BRCA1 associated protein	Homo sapiens	171-176
34568085-5	2021	These interactions were inhibited by free L-lysine, indicating the involvement of lysine binding sites in the Plg molecule.	Lysine	82-88	plasminogen	Homo sapiens	110-113
26995359-1	2016	The m.8344A&gt;G mutation in the MTTK gene, which encodes the mitochondrial transfer RNA for lysine, is traditionally associated with myoclonic epilepsy and ragged-red fibres (MERRF), a multisystemic mitochondrial disease that is characterised by myoclonus, seizures, cerebellar ataxia, and mitochondrial myopathy with ragged-red fibres.	Lysine	93-99	mitochondrially encoded tRNA lysine	Homo sapiens	33-37
34568085-7	2021	Collectively, our data identify a novel bacterial sequence that can interact with lysine binding sites in the Plg molecule.	Lysine	82-88	plasminogen	Homo sapiens	110-113
34339634-9	2021	In the common two paths, it was observed that the multiple lysine residues of RdRp carried the ligands to the binding site like a "bucket brigade".	Lysine	59-65	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	78-82
29235323-6	2016	K 5 interaction is independent and K 1-3 is partly dependent on C-terminal lysine residues.	Lysine	75-81	keratin 13	Homo sapiens	35-40
26903517-1	2016	DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically generate histone Lys-63-linked ubiquitin chains in DSB signaling.	Lysine	193-196	ring finger protein 8	Homo sapiens	101-105
26903517-1	2016	DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically generate histone Lys-63-linked ubiquitin chains in DSB signaling.	Lysine	193-196	ubiquitin conjugating enzyme E2 N	Homo sapiens	154-159
19098283-1	2009	Lipoprotein(a) [Lp(a)] is assembled by the binding of apolipoprotein B (apoB) lysine residues on LDL to lysine binding sites in apolipoprotein(a) [apo(a)] and the subsequent formation of a disulphide bond between apoB and apo(a).	Lysine	78-84	apolipoprotein B	Mus musculus	54-70
19098283-1	2009	Lipoprotein(a) [Lp(a)] is assembled by the binding of apolipoprotein B (apoB) lysine residues on LDL to lysine binding sites in apolipoprotein(a) [apo(a)] and the subsequent formation of a disulphide bond between apoB and apo(a).	Lysine	78-84	apolipoprotein B	Mus musculus	72-76
19098283-1	2009	Lipoprotein(a) [Lp(a)] is assembled by the binding of apolipoprotein B (apoB) lysine residues on LDL to lysine binding sites in apolipoprotein(a) [apo(a)] and the subsequent formation of a disulphide bond between apoB and apo(a).	Lysine	104-110	apolipoprotein B	Mus musculus	54-70
19098283-1	2009	Lipoprotein(a) [Lp(a)] is assembled by the binding of apolipoprotein B (apoB) lysine residues on LDL to lysine binding sites in apolipoprotein(a) [apo(a)] and the subsequent formation of a disulphide bond between apoB and apo(a).	Lysine	104-110	apolipoprotein B	Mus musculus	72-76
19264809-4	2009	Preventing PCNA modification at lysine 164 (pol30-K164R) results in a dramatic increase in GC to TA mutations due to endogenous 8-oxoG in Ogg1-deficient cells.	Lysine	32-38	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	138-142
34470819-8	2021	We identified several evolutionary conserved EXO70 lysine residues and experimentally proved their importance for the EXO70A1-phospholipid interactions.	Lysine	51-57	GTP-Rho binding exocyst subunit EXO70	Saccharomyces cerevisiae S288C	45-50
19569527-1	2009	Nonapeptide H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 corresponding to a modified sequence of autoinhibitory region of myosin light chain kinase (MLCK) was synthesized from L-amino acids and from D-amino acids.	Lysine	18-21	myosin light chain kinase	Homo sapiens	119-144
19569527-1	2009	Nonapeptide H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 corresponding to a modified sequence of autoinhibitory region of myosin light chain kinase (MLCK) was synthesized from L-amino acids and from D-amino acids.	Lysine	18-21	myosin light chain kinase	Homo sapiens	146-150
19258007-9	2009	SCF down-regulated the expression of p27KIP1 and pro-apoptotic factors such as Bim, Bad, and Bax, and this activity was reversed by LY 294002.	Lysine	132-134	KIT ligand	Rattus norvegicus	0-3
27041503-3	2016	Transgenic mice expressing human tau with lysine-to-glutamine mutations to mimic K274 and K281 acetylation (tauKQ) exhibit AD-related memory deficits and impaired hippocampal long-term potentiation (LTP).	Lysine	42-48	microtubule associated protein tau	Homo sapiens	33-36
34378541-1	2021	Acetylation of NF-kappaB"s RelA subunit at lysine-310 (AcLys310) helps to maintain constitutive NF-kappaB activity in cancers such as triple-negative breast cancer (TNBC).	Lysine	43-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	27-31
27090491-1	2016	Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein 1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for genome stability and long-term transcriptional silencing.	Lysine	29-35	chromobox 5	Homo sapiens	95-98
19258007-9	2009	SCF down-regulated the expression of p27KIP1 and pro-apoptotic factors such as Bim, Bad, and Bax, and this activity was reversed by LY 294002.	Lysine	132-134	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	37-44
19258007-9	2009	SCF down-regulated the expression of p27KIP1 and pro-apoptotic factors such as Bim, Bad, and Bax, and this activity was reversed by LY 294002.	Lysine	132-134	BCL2 associated X, apoptosis regulator	Rattus norvegicus	93-96
34448459-7	2021	Reduced histone H3 lysine 9 (H3K9) acetylation was found near the promoter region of caspase-3/-9 after curcumin treatment.	Lysine	19-25	caspase 3	Rattus norvegicus	85-97
19345187-3	2009	We report here that such clearance can be achieved by posttranslational modification of the mutant Huntingtin (Htt) by acetylation at lysine residue 444 (K444).	Lysine	134-140	huntingtin	Mus musculus	99-109
19345187-3	2009	We report here that such clearance can be achieved by posttranslational modification of the mutant Huntingtin (Htt) by acetylation at lysine residue 444 (K444).	Lysine	134-140	huntingtin	Mus musculus	111-114
27068976-10	2016	Subsequently, we have tested the hypothesis whether KLHL12 could promote ubiquitination on non-lysine residues of the D4R.	Lysine	95-101	kelch like family member 12	Homo sapiens	52-58
26903513-5	2016	In fact, we show that the regulation of NY-ESO-1 processing by the ubiquitin receptors Rpn10 and Rpn13 as a well as by the standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites.	Lysine	204-210	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	87-92
34703564-5	2021	Illustrated by a cryo-EM structure of the Cas9/sgRNA/dsDNA dimer, non-specific interactions between DNA ~8 bp downstream of the PAM site and lysines within residues 1151-1156 of Cas9, especially lys1153, are the key elements to mediate the one-dimensional diffusion of Cas9 and cause asymmetric target search regions flanking the PAM.	Lysine	141-148	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	42-46
26912657-4	2016	HDAC8 selectively targeted acetylated histone H3 lysine 27 (H3K27Ac), which is known to associate with active enhancers.	Lysine	49-55	histone deacetylase 8	Mus musculus	0-5
27383565-8	2016	The sterility in xnd-1 mutants is correlated with an increase in the transcriptional activation-associated histone modification, dimethylation of histone H3 lysine 4 (H3K4me2), and aberrant expression of somatic transgenes but overlapping roles with nos-2 and nos-1 suggest that transcriptional repression is achieved by multiple redundant mechanisms.	Lysine	157-163	X chromosome NonDisjunction factor	Caenorhabditis elegans	17-22
19336893-3	2009	In our previous report, we demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active ingredients of ginseng saponins, inhibits human Kv1.4 (hKv1.4) channel currents through the interaction with amino acids, including Lys (K) residue, which is known as K(+) activation and the extracellular tetraethylammonium (TEA) binding site.	Lysine	228-231	potassium voltage-gated channel subfamily A member 4	Homo sapiens	151-157
19295512-6	2009	Here we show that STAT3 phosphorylation and function in the liver were tightly regulated by the nutritional status of an animal, through SirT1-mediated deacetylation of key STAT3 lysine sites.	Lysine	179-185	sirtuin 1	Mus musculus	137-142
34703564-5	2021	Illustrated by a cryo-EM structure of the Cas9/sgRNA/dsDNA dimer, non-specific interactions between DNA ~8 bp downstream of the PAM site and lysines within residues 1151-1156 of Cas9, especially lys1153, are the key elements to mediate the one-dimensional diffusion of Cas9 and cause asymmetric target search regions flanking the PAM.	Lysine	141-148	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	178-182
34703564-5	2021	Illustrated by a cryo-EM structure of the Cas9/sgRNA/dsDNA dimer, non-specific interactions between DNA ~8 bp downstream of the PAM site and lysines within residues 1151-1156 of Cas9, especially lys1153, are the key elements to mediate the one-dimensional diffusion of Cas9 and cause asymmetric target search regions flanking the PAM.	Lysine	141-148	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	269-273
27051521-1	2016	BACKGROUND: NRD convertase, also termed Nardilysin, is a Zn(++) metalloendopeptidase that specifically cleaves the N-terminus of arginine and lysine residues into dibasic moieties.	Lysine	142-148	nardilysin, N-arginine dibasic convertase, NRD convertase 1	Mus musculus	12-26
19223581-3	2009	Here, we show that Lys-28 acetylation modulates the affinity and stability of HIV-1 Tat-CycT1-TAR complexes by enhancing an interaction with the CycT1 Tat-TAR recognition motif.	Lysine	19-22	cyclin T1	Bos taurus	88-93
27051521-1	2016	BACKGROUND: NRD convertase, also termed Nardilysin, is a Zn(++) metalloendopeptidase that specifically cleaves the N-terminus of arginine and lysine residues into dibasic moieties.	Lysine	142-148	nardilysin, N-arginine dibasic convertase, NRD convertase 1	Mus musculus	40-50
34213836-4	2021	Two mechanistically inspired covalent inhibitors ( 1 , IC 50 = 21.0 muM; 9 , IC 50 = 18.7 muM) that modify lysine residues in different Pol beta active sites are characterized.	Lysine	107-113	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	136-144
19223581-3	2009	Here, we show that Lys-28 acetylation modulates the affinity and stability of HIV-1 Tat-CycT1-TAR complexes by enhancing an interaction with the CycT1 Tat-TAR recognition motif.	Lysine	19-22	cyclin T1	Bos taurus	145-150
34213836-5	2021	Despite modifying lysine residues in different active sites, 1 and 9 inactivate the polymerase and lyase activities of Pol beta.	Lysine	18-24	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	119-127
19234061-1	2009	Since the discovery of the first histone lysine demethylase in 2004, two protein families with numerous members have been identified that demethylate various histone lysine residues.	Lysine	41-47	methyl-CpG binding domain protein 2	Homo sapiens	48-59
26718709-0	2016	Identification of lysine K18 acetylation on histone H3 peptide using gold nanoparticles" aggregation behaviour.	Lysine	18-24	keratin 18	Homo sapiens	25-28
34400610-4	2021	In normal mammary gland epithelial cells glucose can promote the nuclear translocation of SerRS by increasing the acetylation of SerRS at lysine 323.	Lysine	138-144	seryl-aminoacyl-tRNA synthetase 2	Mus musculus	129-134
17723255-1	2009	We identified a case of Alzheimer"s disease with a deletion of the lysine residue at codon 280 (DeltaK280) in exon 10-encoded microtubule-binding repeat domain of the tau gene (MAPT).	Lysine	67-73	microtubule associated protein tau	Homo sapiens	167-170
17723255-1	2009	We identified a case of Alzheimer"s disease with a deletion of the lysine residue at codon 280 (DeltaK280) in exon 10-encoded microtubule-binding repeat domain of the tau gene (MAPT).	Lysine	67-73	microtubule associated protein tau	Homo sapiens	177-181
34400610-5	2021	In SerRS knock-in mice bearing acetylation-defective lysine to arginine mutation, we observed increased body weight and adipose tissue mass.	Lysine	53-59	seryl-aminoacyl-tRNA synthetase 2	Mus musculus	3-8
34400610-7	2021	Overexpression of SerRS, in particularly the acetylation-mimetic lysine to glutamine mutant, dramatically inhibits the de novo lipid synthesis and hence greatly suppresses the proliferation of breast cancer cells and the growth of breast cancer xenografts in mice.	Lysine	65-71	seryl-aminoacyl-tRNA synthetase 2	Mus musculus	18-23
26767982-2	2016	The livers of Hint2 knockout (Hint2(-/-)) mice accumulate triglycerides and show a pattern of mitochondrial protein lysine hyperacetylation.	Lysine	116-122	histidine triad nucleotide binding protein 2	Mus musculus	14-19
34385547-5	2021	Our studies suggest that acetylation of Api5 at lysine 251 is mediated by p300 histone acetyltransferase while de-acetylation is carried out by HDAC1.	Lysine	48-54	E1A binding protein p300	Homo sapiens	74-78
26767982-2	2016	The livers of Hint2 knockout (Hint2(-/-)) mice accumulate triglycerides and show a pattern of mitochondrial protein lysine hyperacetylation.	Lysine	116-122	histidine triad nucleotide binding protein 2	Mus musculus	30-35
26742000-4	2016	RESULTS: XPD-Lys/Gln was more common in IFH (n=28; 70%) than in OSCC (n=24; 44.4%) (OR: 0.3; p&lt;0.05).	Lysine	13-16	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	9-12
19192200-5	2009	Rhodopsin, a member of the GPCR or seven-transmembrane spanning receptor superfamily, is composed of a chromophore, 11-cis-retinal that is covalently bound by a protonated Schiff base linkage to the apo-protein opsin at Lys(296) (in bovine opsin).	Lysine	220-223	rhodopsin	Bos taurus	0-9
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	79-82	H3 histone pseudogene 6	Homo sapiens	62-65
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	[Histone H3]-lysine-36 demethylase	Saccharomyces cerevisiae S288C	134-139
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	91-94	H3 histone pseudogene 6	Homo sapiens	62-65
26859163-3	2016	The results showed that the expression levels of histone deacetylase 1 (HDAC1), histone deacetylase 3 (HDAC3), and thymic stromal lymphopoietin (TSLP) were significantly upregulated in mice with allergic rhinitis, whereas H3 acetylation at lysine 9 (H3AcK9) was decreased.	Lysine	240-246	histone deacetylase 1	Mus musculus	49-70
26859163-3	2016	The results showed that the expression levels of histone deacetylase 1 (HDAC1), histone deacetylase 3 (HDAC3), and thymic stromal lymphopoietin (TSLP) were significantly upregulated in mice with allergic rhinitis, whereas H3 acetylation at lysine 9 (H3AcK9) was decreased.	Lysine	240-246	histone deacetylase 1	Mus musculus	72-77
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	Rph1p	Saccharomyces cerevisiae S288C	148-153
26859163-3	2016	The results showed that the expression levels of histone deacetylase 1 (HDAC1), histone deacetylase 3 (HDAC3), and thymic stromal lymphopoietin (TSLP) were significantly upregulated in mice with allergic rhinitis, whereas H3 acetylation at lysine 9 (H3AcK9) was decreased.	Lysine	240-246	histone deacetylase 3	Mus musculus	80-101
26859163-3	2016	The results showed that the expression levels of histone deacetylase 1 (HDAC1), histone deacetylase 3 (HDAC3), and thymic stromal lymphopoietin (TSLP) were significantly upregulated in mice with allergic rhinitis, whereas H3 acetylation at lysine 9 (H3AcK9) was decreased.	Lysine	240-246	histone deacetylase 3	Mus musculus	103-108
19027756-8	2009	Significantly the most chromatid breaks were found in elderly people both Lys/Lys homozygous in the XPD Lys751Gln genotype and C/C or A/A homozygous in the XPC IVS11 genotype (P<0.05).	Lysine	74-77	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	100-103
34098071-2	2021	This study focuses on the function of lysine acetyltransferase 1 (KAT1) in the progression of DR and the epigenetic mechanism.	Lysine	38-44	histone aminotransferase 1	Mus musculus	66-70
19254477-3	2009	Lysine residue corresponding to 6 of ubiquitin, which is involved in the formation of a multi-ubiquitin chain that can bind proteasomal subunit Rpn10/S5a, is also conserved in its ubiquitin-homology domain.	Lysine	0-6	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	144-149
19254477-3	2009	Lysine residue corresponding to 6 of ubiquitin, which is involved in the formation of a multi-ubiquitin chain that can bind proteasomal subunit Rpn10/S5a, is also conserved in its ubiquitin-homology domain.	Lysine	0-6	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	150-153
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	121-127	CD38 molecule	Homo sapiens	34-38
26743126-11	2016	Furthermore, we have identified a lysine degradation pathway as a common regulatory pathway for miR-1260a, miR-1260b, and miR-3182 by using DIANA-mirPath.	Lysine	34-40	microRNA 1260b	Homo sapiens	107-116
19236233-5	2009	In silico modeling suggests that sCD38p and CD4 form stable heterodimers involving, among others, an interaction between lysine 57 (K57) of CD38 and a groove in the CD4 receptor, which, in CD4/gp120 complexes, is partially occupied by a lysine residue of the HIV-1 envelope glycoprotein.	Lysine	237-243	CD38 molecule	Homo sapiens	34-38
34321470-0	2021	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.	Lysine	25-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	15-21
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	195-201	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	271-277
20408502-2	2009	The three-dimensional structures of these CYP2F enzymes have been compared by molecular overlay, especially with regard to the active site regions, and it would appear that the substitution of a lysine (Lys-301) in human CYP2F1 for the usual glutamate (Glu-301) in mouse CYP2F2, goat CYPF3 and rat CYP2F4 prior to the conserved distal threonine residue may well constitute a significant factor in any species differences between these CYP2F enzymes.	Lysine	203-206	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	271-277
19374776-5	2009	By combining the results with previously reported FANTOM4 data, we found that EGR-1 binding sites highly co-localized with CpG islands, acetylated histone H3 lysine 9 binding sites, and CAGE tag clusters.	Lysine	158-164	early growth response 1	Homo sapiens	78-83
26979866-9	2016	RESULTS: We found that (1) SUMO1 knockdown worsened ischemic damage and reduced the protective effect of preconditioning; (2) SUMO1 bound to NCX3 at lysine residue 590, and its silencing increased NCX3 degradation; and (3) NCX3 sumoylation participates in SUMO1 protective role during ischemic preconditioning.	Lysine	149-155	solute carrier family 8 member A3	Rattus norvegicus	141-145
26555343-5	2016	Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(epsilon)-methylated lysine residue in different conformations during catalysis.	Lysine	40-46	complement C4A (Rodgers blood group)	Homo sapiens	25-28
26555343-5	2016	Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(epsilon)-methylated lysine residue in different conformations during catalysis.	Lysine	40-46	complement C5	Homo sapiens	29-32
34236185-1	2021	The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2.	Lysine	78-85	delta/notch like EGF repeat containing	Homo sapiens	36-39
26940749-0	2016	Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.	Lysine	21-27	microtubule associated protein tau	Homo sapiens	50-53
19764654-5	2009	At the same time, the receptor possessing all binding sites for Cbl but lacking C-terminal domain of 63 aminoacid residues (CD63) which contains two autophosphorylation sites (Y1148 and 1173) and 4 lysines, was less ubiquitinated and had more low-ubiquitinated forms comparing to the WT one.	Lysine	198-205	CD63 molecule	Homo sapiens	124-128
34236185-1	2021	The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2.	Lysine	78-85	leiomodin 1	Homo sapiens	163-172
26940749-2	2016	Reversible lysine acetylation has recently emerged as a post-translational modification that may play an important role in the modulation of hTau pathology.	Lysine	11-17	microtubule associated protein tau	Homo sapiens	141-145
26940749-4	2016	However, whether lysine acetylation at position 280 (K280) modulates hTau-induced toxicity in vivo is unknown.	Lysine	17-23	microtubule associated protein tau	Homo sapiens	69-73
34440470-0	2021	Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase.	Lysine	53-59	nuclear receptor binding SET domain protein 3	Homo sapiens	40-44
26934956-0	2016	Extended string-like binding of the phosphorylated HP1alpha N-terminal tail to the lysine 9-methylated histone H3 tail.	Lysine	83-89	chromobox 5	Homo sapiens	51-59
18952095-1	2008	LL-Diaminopimelate aminotransferase (LL-DAP-AT), a pyridoxal phosphate (PLP)-dependent enzyme in the lysine biosynthetic pathways of plants and Chlamydia, is a potential target for the development of herbicides or antibiotics.	Lysine	101-107	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	0-35
18952095-1	2008	LL-Diaminopimelate aminotransferase (LL-DAP-AT), a pyridoxal phosphate (PLP)-dependent enzyme in the lysine biosynthetic pathways of plants and Chlamydia, is a potential target for the development of herbicides or antibiotics.	Lysine	101-107	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	37-46
26934956-1	2016	The chromodomain of HP1alpha binds directly to lysine 9-methylated histone H3 (H3K9me).	Lysine	47-53	chromobox 5	Homo sapiens	20-28
34440470-1	2021	NSD3 is one of six H3K36-specific lysine methyltransferases in metazoans, and the methylation of H3K36 is associated with active transcription.	Lysine	34-40	nuclear receptor binding SET domain protein 3	Homo sapiens	0-4
34440470-2	2021	NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and dimethylated lysine on histone H3.	Lysine	170-176	nuclear receptor binding SET domain protein 3	Homo sapiens	0-4
18977234-5	2008	We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.	Lysine	175-178	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	171-174
18977234-6	2008	We also found that individuals with the G/C genotype of the RAD51-135G/C polymorphism and with the Lys/Lys genotype of the XPD-Lys751Gln polymorphism displayed a lower extent of basal and oxidative DNA damage.	Lysine	99-102	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	123-126
26932671-0	2016	KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.	Lysine	70-76	lysine methyltransferase 2D	Homo sapiens	0-5
18977234-6	2008	We also found that individuals with the G/C genotype of the RAD51-135G/C polymorphism and with the Lys/Lys genotype of the XPD-Lys751Gln polymorphism displayed a lower extent of basal and oxidative DNA damage.	Lysine	103-106	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	123-126
34440470-2	2021	NSD3 is a member of the nuclear receptor-binding SET domain (NSD) family of histone methyltransferases together with NSD1 and NSD2, which generate mono- and dimethylated lysine on histone H3.	Lysine	170-176	nuclear receptor binding SET domain protein 1	Homo sapiens	117-121
34345216-9	2021	Results: This study proved that IGF2BP2 mainly binds to SUMO1 and was SUMOylated at the lysine residues K497, K505 and K509 sites, which can be reduced by SENP1.	Lysine	88-94	SUMO1/sentrin specific peptidase 1	Mus musculus	155-160
19006282-0	2008	Coordination properties of lysine interacting with Co(I) and Co(II).	Lysine	27-33	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	51-56
26862167-6	2016	This "antigen clasping" produced an expansive interface where trimethylated Lys bound to an unusually extensive aromatic cage in one Fab and the histone N terminus to a pocket in the other, thereby rationalizing the high specificity.	Lysine	76-79	FA complementation group B	Homo sapiens	133-136
26902152-0	2016	Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.	Lysine	65-71	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	49-55
34281237-1	2021	SMYD3 is a SET-domain-containing methyltransferase that catalyzes the transfer of methyl groups onto lysine residues of substrate proteins.	Lysine	101-107	SET and MYND domain containing 3	Homo sapiens	0-5
26902152-3	2016	Here we reported the first methyltransferase, SET7/9 (KMT7), capable of methylating YY1 at two highly conserved lysine (K) residues, K173 and K411, located in two distinct domains, one in the central glycine-rich region and the other in the very carboxyl-terminus.	Lysine	112-118	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	46-52
26902152-3	2016	Here we reported the first methyltransferase, SET7/9 (KMT7), capable of methylating YY1 at two highly conserved lysine (K) residues, K173 and K411, located in two distinct domains, one in the central glycine-rich region and the other in the very carboxyl-terminus.	Lysine	112-118	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	54-58
26848759-1	2016	Protein arginine methyltransferase 6 (PRMT6) catalyses asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which has been shown to impede the deposition of histone H3 lysine 4 trimethylation (H3K4me3) by blocking the binding and activity of the MLL1 complex.	Lysine	180-186	lysine methyltransferase 2A	Homo sapiens	258-262
19047142-2	2008	Strikingly, 90% to 95% of the total genomic euchromatic marks histone H3 acetylated at lysine 9 and methylated at lysine 4 is N-Myc-dependent.	Lysine	87-93	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	128-131
19047142-2	2008	Strikingly, 90% to 95% of the total genomic euchromatic marks histone H3 acetylated at lysine 9 and methylated at lysine 4 is N-Myc-dependent.	Lysine	114-120	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	128-131
18948218-3	2008	Immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein, p53, and T-cell proliferation in response to lysine, asparagine, and glutamic acid.	Lysine	160-166	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	115-118
34281237-7	2021	Only in the case that both the methyl donor binding pocket and the target lysine-binding channel had bound species did the simulations show SMYD3 maintaining its conformation in the closed state, indicative of a synergetic effect of the cofactors and target lysine on regulating the conformational change of SMYD3.	Lysine	74-80	SET and MYND domain containing 3	Homo sapiens	140-145
34281237-7	2021	Only in the case that both the methyl donor binding pocket and the target lysine-binding channel had bound species did the simulations show SMYD3 maintaining its conformation in the closed state, indicative of a synergetic effect of the cofactors and target lysine on regulating the conformational change of SMYD3.	Lysine	74-80	SET and MYND domain containing 3	Homo sapiens	308-313
18824541-6	2008	Lysine residues at positions 410 and 411 in a putative TRAF6 consensus binding domain of IRF-5 are the targets of K63-linked ubiquitination.	Lysine	0-6	TNF receptor associated factor 6	Homo sapiens	55-60
26450989-6	2016	Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFbeta treatment.	Lysine	55-61	interferon alpha inducible protein 27	Homo sapiens	16-19
26450989-6	2016	Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFbeta treatment.	Lysine	55-61	cyclin dependent kinase inhibitor 1B	Homo sapiens	20-24
34281237-7	2021	Only in the case that both the methyl donor binding pocket and the target lysine-binding channel had bound species did the simulations show SMYD3 maintaining its conformation in the closed state, indicative of a synergetic effect of the cofactors and target lysine on regulating the conformational change of SMYD3.	Lysine	258-264	SET and MYND domain containing 3	Homo sapiens	140-145
34281237-7	2021	Only in the case that both the methyl donor binding pocket and the target lysine-binding channel had bound species did the simulations show SMYD3 maintaining its conformation in the closed state, indicative of a synergetic effect of the cofactors and target lysine on regulating the conformational change of SMYD3.	Lysine	258-264	SET and MYND domain containing 3	Homo sapiens	308-313
34179622-11	2021	Lysine residue K228 with both KCr and Khib modifications in ENO1 was on its surface and made it accessible for p300 mediating dynamic modifications.	Lysine	0-6	E1A binding protein p300	Homo sapiens	111-115
26678563-8	2016	Furthermore, we find that OPN purified from human urine contains the Lys(154)-Gln(193) isopeptide bond, indicating that intramolecular cross-linking of OPN occurs in vivo.	Lysine	69-72	secreted phosphoprotein 1	Homo sapiens	26-29
26678563-8	2016	Furthermore, we find that OPN purified from human urine contains the Lys(154)-Gln(193) isopeptide bond, indicating that intramolecular cross-linking of OPN occurs in vivo.	Lysine	69-72	secreted phosphoprotein 1	Homo sapiens	152-155
18815416-2	2008	BRD4 and its family members contain two bromodomains known to bind acetylated lysine, and a conserved ET domain whose function is unclear.	Lysine	78-84	bromodomain containing 4	Mus musculus	0-4
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	lysine methyltransferase 2A	Homo sapiens	4-36
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	lysine methyltransferase 2A	Homo sapiens	38-42
34117888-4	2021	Here, we show that IP3/Ca2+ signals in vGlutVGN6341 neurons drive expression of Set2, a gene encoding Drosophila Histone 3 Lysine 36 methyltransferase.	Lysine	123-129	SET domain containing 2	Drosophila melanogaster	80-84
18995842-4	2008	SIRT2 deacetylates lysine residues in the catalytic domain of p300 and restores binding of p300 to the PIC.	Lysine	19-25	sirtuin 2	Homo sapiens	0-5
26759222-6	2016	H2B regained acetylation on multiple lysine residues, phosphorylation on Thr19, and methylation on Lys23 and Lys43 in the DU-145 cells after sodium butyrate treatment.	Lysine	37-43	H2B clustered histone 21	Homo sapiens	0-3
26717573-0	2015	KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant.	Lysine	20-26	kelch like family member 12	Homo sapiens	0-6
26717573-2	2015	KLHL12 PROMOTES UBIQUITINATION OF THE DOPAMINE D4 RECEPTOR ON NON-LYSINE RESIDUES: In previous studies we have shown that KLHL12, a BTB-Kelch protein, specifically interacts with the polymorphic repeats of the dopamine D4 receptor and enhances its ubiquitination, which, however, has no influence on receptor degradation.	Lysine	66-72	kelch like family member 12	Homo sapiens	0-6
26717573-2	2015	KLHL12 PROMOTES UBIQUITINATION OF THE DOPAMINE D4 RECEPTOR ON NON-LYSINE RESIDUES: In previous studies we have shown that KLHL12, a BTB-Kelch protein, specifically interacts with the polymorphic repeats of the dopamine D4 receptor and enhances its ubiquitination, which, however, has no influence on receptor degradation.	Lysine	66-72	dopamine receptor D4	Homo sapiens	38-58
26717573-2	2015	KLHL12 PROMOTES UBIQUITINATION OF THE DOPAMINE D4 RECEPTOR ON NON-LYSINE RESIDUES: In previous studies we have shown that KLHL12, a BTB-Kelch protein, specifically interacts with the polymorphic repeats of the dopamine D4 receptor and enhances its ubiquitination, which, however, has no influence on receptor degradation.	Lysine	66-72	kelch like family member 12	Homo sapiens	122-128
26717573-2	2015	KLHL12 PROMOTES UBIQUITINATION OF THE DOPAMINE D4 RECEPTOR ON NON-LYSINE RESIDUES: In previous studies we have shown that KLHL12, a BTB-Kelch protein, specifically interacts with the polymorphic repeats of the dopamine D4 receptor and enhances its ubiquitination, which, however, has no influence on receptor degradation.	Lysine	66-72	dopamine receptor D4	Homo sapiens	210-230
26717573-3	2015	In this study we provide evidence that KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues.	Lysine	105-111	kelch like family member 12	Homo sapiens	39-45
18722556-2	2008	Error-prone replication involves translesion polymerases and requires monoubiquitylation at lysine (K) 164 of PCNA by the Rad6 and Rad18 enzymes.	Lysine	92-98	proliferating cell nuclear antigen	Homo sapiens	110-114
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	146-152	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-19
18767117-8	2008	Supplementation of Lys, His, and Thr abrogated mTOR Ser 2448 phosphorylation, with no effect on Akt Ser 473-an mTORC2 target.	Lysine	19-22	mechanistic target of rapamycin kinase	Mus musculus	47-51
18767117-10	2008	The individual supplementation of Lys, His, and Thr maintained a low level of IRS-1 phosphorylation, which was dose-dependently increased by their combined addition.	Lysine	34-37	insulin receptor substrate 1	Mus musculus	78-83
26717573-3	2015	In this study we provide evidence that KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues.	Lysine	105-111	dopamine receptor D4	Homo sapiens	77-97
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	146-152	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	21-24
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	146-152	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	42-91
26586479-4	2015	Here, we demonstrated that the protein lysine methyltransferase SUV420H1 tri-methylated ERK1 at lysines 302 and 361, and that substitution of methylation sites diminished phosphorylation levels of ERK1.	Lysine	96-103	lysine methyltransferase 5B	Homo sapiens	64-72
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	146-152	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	93-98
18799617-0	2008	HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.	Lysine	37-43	NAD-dependent histone deacetylase HST3	Saccharomyces cerevisiae S288C	0-4
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	154-157	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	0-19
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	154-157	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	21-24
26515065-3	2015	Following food deprivation, the expression and acetylation of the p65 of NF-kappaB on lysine 310 increase markedly in muscles.	Lysine	86-92	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	66-69
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	154-157	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	42-91
26515065-4	2015	NF-kappaB inhibition in mouse muscles by overexpression of the IkappaBalpha superrepressor (IkappaBalpha-SR) or of p65 mutated at Lys-310 prevented atrophy.	Lysine	130-133	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	115-118
18687677-5	2008	In the 293T cells, SIRT1 overexpression diminished lysine acetylation of LKB1 and concurrently increased its activity, cytoplasmic/nuclear ratio, and association with the LKB1 activator STRAD.	Lysine	51-57	serine/threonine kinase 11	Homo sapiens	73-77
18687677-7	2008	Mass spectrometric analysis established that acetylation of LKB1 occurs on multiple, but specific, lysine residues; however, only mutation of lysine 48 to arginine, which mimics deacetylation, reproduced all of the effects of activated SIRT1.	Lysine	99-105	serine/threonine kinase 11	Rattus norvegicus	60-64
34107376-3	2021	Lysyl hydroxylase 2 (LH2), encoded by the Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) gene, catalyzes hydroxylation of telopeptidyl lysine (Lys) residues of fibrillar collagens which then undergo subsequent modifications to form stable intermolecular cross-links that change the biomechanical properties (i.e. quality) of the TME.	Lysine	154-157	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	93-98
18687677-10	2008	Consistent with the results in cultured cells, total LKB1 lysine acetylation was decreased by 60% in the liver of 48-h starved rats compared with starved-refed rats, and this was associated with modest but significant increases in both LKB1 and AMPK activities.	Lysine	58-64	serine/threonine kinase 11	Rattus norvegicus	53-57
34158847-10	2021	Mutation of the demalonylation lysine sites (K66, K130, and K162) of DDX3 increased ifnbeta transcription.	Lysine	31-37	DEAD box helicase 3, X-linked	Mus musculus	69-73
18716620-3	2008	We have previously reported that ubiquitinylation of PTEN at specific lysine residues regulates its nuclear-cytoplasmic partitioning.	Lysine	70-76	phosphatase and tensin homolog	Homo sapiens	53-57
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	46-49	TNF receptor associated factor 6	Homo sapiens	31-36
26330467-3	2015	Here, we analyze differential histone modifications between WT and MED23(-/-) (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone modification.	Lysine	129-135	H2B clustered histone 21	Homo sapiens	102-105
26319017-1	2015	The alpha, beta and gamma isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains.	Lysine	111-117	chromobox 5	Homo sapiens	48-73
26319017-1	2015	The alpha, beta and gamma isoforms of mammalian heterochromatin protein 1 (HP1) selectively bind to methylated lysine 9 of histone H3 via their chromodomains.	Lysine	111-117	chromobox 5	Homo sapiens	75-78
26508549-5	2015	Finally, we have observed that alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells, presumably via restoring the activity of cellular alpha-KG-dependent DNA hydroxylases and histone H3 lysine demethylases.	Lysine	137-143	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	156-160
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	46-49	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	82-86
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	46-49	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	110-114
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	87-90	TNF receptor associated factor 6	Homo sapiens	31-36
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	87-90	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	82-86
18758450-8	2008	Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation.	Lysine	87-90	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	110-114
34158847-11	2021	Furthermore, the acetylation on lysine 118 of DDX3 positively regulated ifnbeta transcription, whereas Sirt5 could not deacetylate this site.	Lysine	32-38	DEAD box helicase 3, X-linked	Mus musculus	46-50
34069243-10	2021	Overall, the replacement of lysine in SVS-1 with other basic amino acids significantly influenced its binding and internalization into cancer cells, as well as its in vivo pharmacokinetic profile.	Lysine	28-34	amine oxidase copper containing 1-like 3	Mus musculus	38-43
18674781-7	2008	Interestingly, while Id-1 did not induce HBX-ubiquitination, we found that removal of all the lysine residues of the HBX protein protects it from the effect of Id-1, indicating that ubiquitination is still required for the Id-1-mediated HBX degradation.	Lysine	94-100	X protein	Hepatitis B virus	117-120
18674781-7	2008	Interestingly, while Id-1 did not induce HBX-ubiquitination, we found that removal of all the lysine residues of the HBX protein protects it from the effect of Id-1, indicating that ubiquitination is still required for the Id-1-mediated HBX degradation.	Lysine	94-100	X protein	Hepatitis B virus	117-120
26807165-2	2015	To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs).	Lysine	33-39	keratin 79	Homo sapiens	73-76
34306974-6	2021	In addition, the molecular interaction between the lysine motif of ctCTLA-4 and PKC-eta is critical for Foxp3 expression.	Lysine	51-57	forkhead box P3	Homo sapiens	104-109
26555036-7	2015	RESULTS: The close proximity of Arg/Lys amino acids and a proline two residues N-terminal to the phosphorylated residue both improve recognition of the substrate by CDK5.	Lysine	36-39	cyclin dependent kinase 5	Homo sapiens	165-169
30090230-5	2015	Several small molecules were found to bind in the lysine-binding pocket of the kringle 1 domain of HGF/SF and its truncated splice variant NK1.	Lysine	50-56	tachykinin receptor 1	Homo sapiens	139-142
30090230-7	2015	Thus we demonstrate that targeting the lysine-binding pocket of NK1 is an effective strategy to generate MET receptor antagonists and we offer proof of concept that the HGF/SF-MET interface may be successfully targeted with small molecules.	Lysine	39-45	tachykinin receptor 1	Homo sapiens	64-67
18791070-3	2008	Here, we show that the hERG1 polymorphism at codon 897, which is read as a Thr instead of a Lys, creates a phosphorylation site for the Akt protein kinase on the Kv11.1 channel protein.	Lysine	92-95	potassium voltage-gated channel subfamily H member 2	Homo sapiens	23-28
18791070-3	2008	Here, we show that the hERG1 polymorphism at codon 897, which is read as a Thr instead of a Lys, creates a phosphorylation site for the Akt protein kinase on the Kv11.1 channel protein.	Lysine	92-95	potassium voltage-gated channel subfamily H member 2	Homo sapiens	162-168
18601901-2	2008	Prior to incorporation into chromatin, newly synthesized histones H3 and H4 are highly acetylated in pre-deposition complex, wherein H4 is di-acetylated at Lys-5 and Lys-12 residues by histone acetyltransferase-1 (Hat1), but their role in histone metabolism is still unclear.	Lysine	156-159	histone acetyltransferase 1	Gallus gallus	185-212
34094832-5	2021	Using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) analysis, PARP16 was identified as a novel target gene for histone H3 lysine 4 (H3K4) methyltransferase SMYD3, and SMYD3 could bind to the promoter of Parp16 and increased H3K4me3 level to activate its host gene"s transcription, which causes UPR activation and SMC proliferation.	Lysine	146-152	poly(ADP-ribose) polymerase family member 16	Homo sapiens	86-92
18601901-2	2008	Prior to incorporation into chromatin, newly synthesized histones H3 and H4 are highly acetylated in pre-deposition complex, wherein H4 is di-acetylated at Lys-5 and Lys-12 residues by histone acetyltransferase-1 (Hat1), but their role in histone metabolism is still unclear.	Lysine	166-169	histone acetyltransferase 1	Gallus gallus	185-212
34094832-5	2021	Using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) analysis, PARP16 was identified as a novel target gene for histone H3 lysine 4 (H3K4) methyltransferase SMYD3, and SMYD3 could bind to the promoter of Parp16 and increased H3K4me3 level to activate its host gene"s transcription, which causes UPR activation and SMC proliferation.	Lysine	146-152	SET and MYND domain containing 3	Homo sapiens	180-185
34094832-5	2021	Using chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) analysis, PARP16 was identified as a novel target gene for histone H3 lysine 4 (H3K4) methyltransferase SMYD3, and SMYD3 could bind to the promoter of Parp16 and increased H3K4me3 level to activate its host gene"s transcription, which causes UPR activation and SMC proliferation.	Lysine	146-152	poly(ADP-ribose) polymerase family member 16	Homo sapiens	227-233
18617513-3	2008	In conjunction with the dimeric E2 enzyme Ubc13-Uev1A, the N-terminal RING domain of TRAF6 functions as an E3 ubiquitin (Ub) ligase that facilitates its own site-specific ubiquitination through the generation of a Lys-63-linked poly-Ub chain.	Lysine	214-217	ubiquitin conjugating enzyme E2 N	Homo sapiens	42-47
25809859-5	2015	This method uses novel cysteine (NAC) and novel lysine derivatives (NAL), which were synthesized by introducing a naphthalene ring to the amine group of cysteine and lysine residues.	Lysine	166-172	synuclein alpha	Homo sapiens	33-36
34141456-2	2021	Here, we aimed to discuss the role of lncRNA interleukin enhancer-binding factor 3-antisense RNA 1 (ILF3-AS1)/enhancer of zeste homolog 2 (EZH2)/cyclin-dependent kinase inhibitor 2 (CDKN2A)/histone 3 (H3) lysine 27 trimethylation (H3K27me3) in cell proliferation and metastasis of CRC.	Lysine	205-211	interleukin enhancer binding factor 3	Mus musculus	100-104
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Lysine	61-67	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-53
26503230-2	2015	TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites.	Lysine	104-110	proliferating cell nuclear antigen	Homo sapiens	59-93
26503230-2	2015	TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites.	Lysine	104-110	proliferating cell nuclear antigen	Homo sapiens	95-99
18765789-3	2008	DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4.	Lysine	97-103	double PHD fingers 3	Danio rerio	0-4
18765789-4	2008	Thus, DPF3 may represent the first plant homeodomains that bind acetylated lysines, a feature previously only shown for the bromodomain.	Lysine	75-82	double PHD fingers 3	Danio rerio	6-10
18393272-0	2008	Alternative splicing of Nav1.5: an electrophysiological comparison of "neonatal" and "adult" isoforms and critical involvement of a lysine residue.	Lysine	132-138	sodium voltage-gated channel alpha subunit 5	Homo sapiens	24-30
35512565-1	2022	Acetylation of histone lysine residues by histone acetyltransferase (HAT) p300 and its paralog CBP play important roles in gene regulation in health and diseases.	Lysine	23-29	E1A binding protein p300	Homo sapiens	74-78
18393272-7	2008	In this "neonatal K211D" mutant, the electrophysiological parameters studied strongly shifted back towards the "adult", that is the lysine residue was primarily responsible for the electrophysiological effects of Nav1.5 D1:S3 splicing.	Lysine	132-138	sodium voltage-gated channel alpha subunit 5	Homo sapiens	213-219
18523136-8	2008	We showed that the proximal region of the intracellular C terminus of P2X(1) subunit directly binds to PI(4,5)P(2) and other anionic phospholipids, and we identified the basic residue Lys(364) as a critical determinant for phospholipid binding and sensitivity to wortmannin.	Lysine	184-187	purinergic receptor P2X 1	Homo sapiens	70-76
26320100-3	2015	EHMT1/2 catalyze mono- and dimethylation of lysine 9 on histone 3 (H3K9), raising the possibility that H3K9Me2, a repressive chromatin mark, plays a role in silencing gamma-globin expression.	Lysine	44-50	euchromatic histone lysine methyltransferase 1	Homo sapiens	0-5
35248525-1	2022	AIMS: Lysine-specific demethylase 5B (KDM5B) is an epigenetic regulator of chromatin that catalyzes the demethylation of histone 3 lysine 4.	Lysine	131-137	lysine demethylase 5B	Homo sapiens	6-36
26257145-6	2015	Here, we report a method for separation of endogenous HILS1 protein from other rat testis linker histones by reversed-phase high-performance liquid chromatography (RP-HPLC) and identification of 15 novel post-translational modifications of HILS1, which include lysine acetylation and serine/threonine/tyrosine phosphorylation sites.	Lysine	261-267	histone linker H1 domain, spermatid-specific 1	Rattus norvegicus	54-59
18722180-5	2008	Mutating the highly conserved N terminus increases substrate ubiquitination and the number of substrate lysines targeted, allows ubiquitination of APC substrates lacking their destruction boxes, increases resistance to the APC inhibitors Emi1 and BubR1 in vitro, and bypasses the spindle checkpoint in vivo.	Lysine	104-111	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	247-252
35248525-1	2022	AIMS: Lysine-specific demethylase 5B (KDM5B) is an epigenetic regulator of chromatin that catalyzes the demethylation of histone 3 lysine 4.	Lysine	131-137	lysine demethylase 5B	Homo sapiens	38-43
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	72-77
26435321-8	2015	These results indicate that lysine methylation by SETD7 is important for the fine-tuning of ROS signaling through its regulation on pro-inflammatory responses, mitochondrial function and the NFE2L2/ARE pathway.	Lysine	28-34	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	50-55
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	83-88
35501461-8	2022	Mechanistically, Nedd4 enhanced TGF-beta signal transduction mediated tumor progression by directly binding to TGF-beta type I receptor (TGFBR1) and forming K27-linked ubiquitin at Lysine 391.	Lysine	181-187	transforming growth factor alpha	Homo sapiens	32-40
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	275-278	chemokine like factor	Homo sapiens	83-88
26431207-5	2015	CUL4A-DDB1-CDT2 E3 ligase targets lysine 585 within the C-terminal region of CRY1 protein, shown by the CRY1 585KA mutant"s resistance to ubiquitination and degradation mediated by the CUL4A-DDB1 complex.	Lysine	34-40	cryptochrome circadian regulator 1	Homo sapiens	77-81
26431207-5	2015	CUL4A-DDB1-CDT2 E3 ligase targets lysine 585 within the C-terminal region of CRY1 protein, shown by the CRY1 585KA mutant"s resistance to ubiquitination and degradation mediated by the CUL4A-DDB1 complex.	Lysine	34-40	cryptochrome circadian regulator 1	Homo sapiens	104-108
26116705-5	2015	A mutagenesis assay and mass spectrometric analyses revealed that beta-catenin was monomethylated by SET7/9 at lysine residue 180.	Lysine	111-117	catenin beta 1	Homo sapiens	66-78
18541669-6	2008	Mof(-/-) embryos fail to acetylate histone 4 lysine 16 (H4K16) but have normal acetylation of other N-terminal histone lysine residues.	Lysine	45-51	K(lysine) acetyltransferase 8	Mus musculus	0-3
18541669-6	2008	Mof(-/-) embryos fail to acetylate histone 4 lysine 16 (H4K16) but have normal acetylation of other N-terminal histone lysine residues.	Lysine	119-125	K(lysine) acetyltransferase 8	Mus musculus	0-3
26116705-5	2015	A mutagenesis assay and mass spectrometric analyses revealed that beta-catenin was monomethylated by SET7/9 at lysine residue 180.	Lysine	111-117	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	101-107
26344566-5	2015	Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy.	Lysine	150-153	ATM serine/threonine kinase	Homo sapiens	68-71
35501461-8	2022	Mechanistically, Nedd4 enhanced TGF-beta signal transduction mediated tumor progression by directly binding to TGF-beta type I receptor (TGFBR1) and forming K27-linked ubiquitin at Lysine 391.	Lysine	181-187	keratin 27	Homo sapiens	157-160
18622391-1	2008	Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior monoubiquitination of histone H2B.	Lysine	25-31	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	50-54
35404465-1	2022	Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function.	Lysine	31-37	PR/SET domain containing protein 7	Drosophila melanogaster	68-72
26366710-1	2015	The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known.	Lysine	22-28	lysine (K)-specific methyltransferase 2D	Mus musculus	64-69
35404465-1	2022	Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function.	Lysine	31-37	lysine methyltransferase 5A	Homo sapiens	73-78
26366710-1	2015	The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known.	Lysine	22-28	lysine (K)-specific methyltransferase 2D	Mus musculus	224-229
18477475-0	2008	Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7.	Lysine	24-30	hes family bHLH transcription factor 7	Homo sapiens	96-100
18477475-3	2008	Here, we found that lysine residues (K22, K52, and K55) in the bHLH domain are essential not only for the instability of Hes7 protein but also for the transcriptional repressor activity.	Lysine	20-26	hes family bHLH transcription factor 7	Homo sapiens	121-125
26172293-4	2015	Thereby, the SETD2 binding capacity to substrate histone H3 is weakened, triggering a reduction of trimethylation on histone H3 thirty-sixth lysine, and thereby the H3K36me3-hMSH2-hMSH6-SKP2 complex is also decreased.	Lysine	141-147	mutS homolog 6	Homo sapiens	180-185
18477475-4	2008	Introduction of lysine-to-arginine mutations into the bHLH domain led to stabilization of Hes7 protein and to abnormalities in either the N box-binding activity or partner preference in heterodimer formation.	Lysine	16-22	hes family bHLH transcription factor 7	Homo sapiens	90-94
35446024-6	2022	PEGylation of the MMP-targeting N-terminal domain of TIMP2 (N-TIMP2), via either cysteine or lysine residues, resulted in a significant decrease in N-TIMP2 affinity toward MMP-14 or multisite conjugation and conjugate heterogeneity, respectively.	Lysine	93-99	tissue inhibitor of metalloproteinase 2	Mus musculus	53-58
18556019-1	2008	Dihydrodipicolinate synthase (DHDPS) is an essential enzyme in (S)-lysine biosynthesis and an important antibiotic target.	Lysine	63-73	dihydrodipicolinate synthase	Escherichia coli	0-28
26418248-0	2015	PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination.	Lysine	92-98	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	Mus musculus	14-19
35446024-6	2022	PEGylation of the MMP-targeting N-terminal domain of TIMP2 (N-TIMP2), via either cysteine or lysine residues, resulted in a significant decrease in N-TIMP2 affinity toward MMP-14 or multisite conjugation and conjugate heterogeneity, respectively.	Lysine	93-99	tissue inhibitor of metalloproteinase 2	Mus musculus	60-67
18556019-1	2008	Dihydrodipicolinate synthase (DHDPS) is an essential enzyme in (S)-lysine biosynthesis and an important antibiotic target.	Lysine	63-73	dihydrodipicolinate synthase	Escherichia coli	30-35
35446024-6	2022	PEGylation of the MMP-targeting N-terminal domain of TIMP2 (N-TIMP2), via either cysteine or lysine residues, resulted in a significant decrease in N-TIMP2 affinity toward MMP-14 or multisite conjugation and conjugate heterogeneity, respectively.	Lysine	93-99	tissue inhibitor of metalloproteinase 2	Mus musculus	150-155
35532818-1	2022	NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases.	Lysine	98-104	nuclear receptor binding SET domain protein 1	Homo sapiens	0-4
18628398-4	2008	Our data reveal that the presence of stalled Pol II at this latter group of genes enhances gene expression by maintaining a permissive chromatin architecture around the promoter-proximal region, and that loss of Pol II stalling at these promoters is accompanied by a significant increase in nucleosome occupancy and a decrease in histone H3 Lys 4 trimethylation.	Lysine	341-344	RNA polymerase II 215kD subunit	Drosophila melanogaster	45-51
18628398-4	2008	Our data reveal that the presence of stalled Pol II at this latter group of genes enhances gene expression by maintaining a permissive chromatin architecture around the promoter-proximal region, and that loss of Pol II stalling at these promoters is accompanied by a significant increase in nucleosome occupancy and a decrease in histone H3 Lys 4 trimethylation.	Lysine	341-344	RNA polymerase II 215kD subunit	Drosophila melanogaster	212-218
26251516-8	2015	Mapping Ran sumoylation sites revealed that transport receptors may simply block access of the E2-conjugating enzyme Ubc9, however the acceptor lysines are perfectly accessible in Ran/NTF2 complexes.	Lysine	144-151	RAN, member RAS oncogene family	Homo sapiens	8-11
26032282-6	2015	Two somatic mutations and one constitutional variant in the well-established cancer gene lysine (K)-specific methyltransferase 2D (KMT2D, MLL2) were discovered in one sample each, prompting KMT2D screening using focused exome-sequencing in the verification cohort.	Lysine	89-95	lysine methyltransferase 2D	Homo sapiens	131-136
35532818-1	2022	NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases.	Lysine	98-104	nuclear receptor binding SET domain protein 3	Homo sapiens	16-20
26032282-6	2015	Two somatic mutations and one constitutional variant in the well-established cancer gene lysine (K)-specific methyltransferase 2D (KMT2D, MLL2) were discovered in one sample each, prompting KMT2D screening using focused exome-sequencing in the verification cohort.	Lysine	89-95	lysine methyltransferase 2D	Homo sapiens	138-142
26032282-6	2015	Two somatic mutations and one constitutional variant in the well-established cancer gene lysine (K)-specific methyltransferase 2D (KMT2D, MLL2) were discovered in one sample each, prompting KMT2D screening using focused exome-sequencing in the verification cohort.	Lysine	89-95	lysine methyltransferase 2D	Homo sapiens	190-195
18632619-9	2008	Taken together, our results show that c-Cbl constitutes a new ligase responsible for the ubiquitination of IGF-IR and that it complements the action of Mdm2 on ubiquitin lysine residue specificity, responsiveness to IGF-I, and type of endocytic pathway used.	Lysine	170-176	Cbl proto-oncogene	Homo sapiens	38-43
35503397-6	2022	Mechanistically, SMYD2 physically interacts with HNRNPK and mediates lysine monomethylation at K422 of HNRNPK, which substantially increases RNA binding activity.	Lysine	69-75	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	103-109
18450745-0	2008	Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.	Lysine	73-79	AXL receptor tyrosine kinase	Homo sapiens	91-94
18450745-9	2008	The CDY chromodomain exhibits discriminatory binding to lysine-methylated ARK(S/T) motifs, whereas the CDYL2 chromodomain binds with comparable strength to multiple ARK(S/T) motifs.	Lysine	56-62	AXL receptor tyrosine kinase	Homo sapiens	74-77
35504875-6	2022	In addition, chromatin immunoprecipitation, RNA-binding protein immunoprecipitation, and RNA pull-down assays predicted and validated that LINC00478 targeted lysine-specific demethylase-1 (KDM1A) and down-regulated the expression of MMP9 by decreasing the monomethylation on lysine 4 of histone H3 (H3K4me1) of MMP9 promoter.	Lysine	158-164	mir-99a-let-7c cluster host gene	Homo sapiens	139-148
18457658-1	2008	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an ubiquitin ligase that regulates a diverse array of physiological processes via forming Lys-63 linked polyubiquitin chains.	Lysine	152-155	TNF receptor associated factor 6	Homo sapiens	0-50
18457658-1	2008	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an ubiquitin ligase that regulates a diverse array of physiological processes via forming Lys-63 linked polyubiquitin chains.	Lysine	152-155	TNF receptor associated factor 6	Homo sapiens	52-57
18457658-2	2008	In this study, the lysine selection process for TRAF6/p62 ubiquitination was examined.	Lysine	19-25	TNF receptor associated factor 6	Homo sapiens	48-53
18457658-5	2008	Interestingly, Lysine 811 in TrkB was selected for ubiquination, and mutation of Lysine 811 diminished the formation of TRAF6/p62 complex that is necessary for effective ubiquination.	Lysine	81-87	TNF receptor associated factor 6	Homo sapiens	120-125
26237645-4	2015	Locally generated fumarate inhibits KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 Lys 36; in turn, this increases the accumulation of the Ku70-containing DNA-PK at DSB regions for non-homologous end-joining DNA repair and cell survival.	Lysine	122-125	lysine demethylase 2B	Homo sapiens	36-41
35504875-6	2022	In addition, chromatin immunoprecipitation, RNA-binding protein immunoprecipitation, and RNA pull-down assays predicted and validated that LINC00478 targeted lysine-specific demethylase-1 (KDM1A) and down-regulated the expression of MMP9 by decreasing the monomethylation on lysine 4 of histone H3 (H3K4me1) of MMP9 promoter.	Lysine	275-281	mir-99a-let-7c cluster host gene	Homo sapiens	139-148
26279576-4	2015	Oncogenic HRas(G12V) elevates histone 3 lysine 27 acetylation (H3K27ac) levels at enhancers near the transcription factor Gata4 and the kinase Prkcb, as well as their expression levels.	Lysine	40-46	HRas proto-oncogene, GTPase	Homo sapiens	10-14
18512960-13	2008	The average value of the experimental DeltaG(E)() for the six lysine methyl transfer reactions catalyzed by vSET, LSMT, and SET7/9 with p53 as a substrate is 22.1 +/- 1.0 kcal/mol, and the computed average (DeltaG(C)()) is 22.2 +/- 0.8 kcal/mol.	Lysine	62-68	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	124-130
35349166-3	2022	However, the roles of some atypical poly-ubiquitin topologies, in particular linkages via lysine 27 (K27), remain poorly understood due to a lack of tools for their specific detection and manipulation.	Lysine	90-96	keratin 27	Homo sapiens	101-104
18559531-3	2008	Knockdown of histone deacetylase (HDAC) 6, which deacetylates lysine residues in hsp90, induces reversible hyperacetylation and attenuates ATP binding and chaperone function of hsp90.	Lysine	62-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-86
26307012-5	2015	The amount of acetylated histone H3 lysine 9 (H3K9) associated with the CRH promoter was greater in cytotrophoblasts from full-term placenta than in those from midterm placenta.	Lysine	36-42	corticotropin releasing hormone	Homo sapiens	72-75
35503228-1	2022	Purpose: We aimed to explore the effect of lysine acetyltransferase KAT5 on allergic conjunctivitis (AC).	Lysine	43-49	K(lysine) acetyltransferase 5	Mus musculus	68-72
26157143-7	2015	Moreover, the immunoprecipitation results clearly demonstrate that PIP5K SUMOylated at Lys-490 interacts with components of the chromatin silencing machinery, H3K9me3 and heterochromatin protein 1alpha.	Lysine	87-90	chromobox 5	Homo sapiens	171-201
18559531-3	2008	Knockdown of histone deacetylase (HDAC) 6, which deacetylates lysine residues in hsp90, induces reversible hyperacetylation and attenuates ATP binding and chaperone function of hsp90.	Lysine	62-68	heat shock protein 90 alpha family class A member 1	Homo sapiens	177-182
18559531-4	2008	Here, using mass spectrometry, we identified seven lysine residues in hsp90alpha that are hyperacetylated after treatment of eukaryotic cells with a pan-HDAC inhibitor that also inhibits HDAC6.	Lysine	51-57	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-80
18559531-5	2008	Depending on the specific lysine residue in the middle domain involved, although acetylation affects ATP, cochaperone, and client protein binding to hsp90alpha, acetylation of all seven lysines increased the binding of hsp90alpha to 17-allyl-amino-demethoxy geldanamycin.	Lysine	26-32	heat shock protein 90 alpha family class A member 1	Homo sapiens	219-229
18559531-5	2008	Depending on the specific lysine residue in the middle domain involved, although acetylation affects ATP, cochaperone, and client protein binding to hsp90alpha, acetylation of all seven lysines increased the binding of hsp90alpha to 17-allyl-amino-demethoxy geldanamycin.	Lysine	186-193	heat shock protein 90 alpha family class A member 1	Homo sapiens	219-229
35503228-7	2022	Mechanically, the phosphorylation of PI3K and Akt and the levels of histone H3 lysine 27 acetylation (H3K27ac) were enhanced in EAC mice, whereas the overexpression of KAT5 promoted and NU9056 repressed the phenotype in the mice.	Lysine	79-85	K(lysine) acetyltransferase 5	Mus musculus	168-172
26240340-1	2015	Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations.	Lysine	33-39	H2B clustered histone 21	Homo sapiens	26-29
18378668-5	2008	We determined that the carboxyl-terminal cytosolic region of BI-1 contains a lysine-rich motif (EKDKKKEKK) resembling the pH-sensing domains of ion channels.	Lysine	77-83	transmembrane BAX inhibitor motif containing 6	Homo sapiens	61-65
35609316-5	2022	EZH2 catalyzed trimethylation of lysine 27 on histone 3 (H3K27me3) in GADD45A promoter to suppress its transcription.	Lysine	33-39	growth arrest and DNA damage inducible alpha	Homo sapiens	70-77
18449190-3	2008	One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4).	Lysine	63-69	H2B clustered histone 21	Homo sapiens	49-52
26240340-1	2015	Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations.	Lysine	33-39	H2B clustered histone 21	Homo sapiens	45-48
25968119-5	2015	Pretreatment with Lys also caused Gcdh-/- astrocytes to induce extensive death of striatal and cortical neurons when compared with milder effect in WT astrocytes.	Lysine	18-21	glutaryl-Coenzyme A dehydrogenase	Mus musculus	34-38
25968119-7	2015	In contrast, Lys or GA direct exposure on Gcdh-/- or WT striatal neurons cultured in the absence of astrocytes was not toxic, indicating that neuronal death is mediated by astrocytes.	Lysine	13-16	glutaryl-Coenzyme A dehydrogenase	Mus musculus	42-46
18481301-5	2008	The ubiquitin-fusion protein includes an ubiquitin monomer of 76 amino acids with a 6-amino acid motif (LRLRGG) and 3 conserved lysine functional sites, which participate in the formation of the ubiquitin-protease complex.	Lysine	128-134	ubiquitin	Musca domestica	4-13
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	C-C motif chemokine ligand 20	Homo sapiens	256-285
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	C-C motif chemokine ligand 20	Homo sapiens	287-292
18577015-8	2008	The nutritional properties of sample showed that enrichment of semolina with MPI had a pronounced effect on lysine, cysteine, arginine, and histidine contents.	Lysine	108-114	mannose phosphate isomerase	Homo sapiens	77-80
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	E2F transcription factor 2	Homo sapiens	299-325
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	E2F transcription factor 2	Homo sapiens	327-331
25968119-8	2015	In summary, GCDH-defective astrocytes actively contribute to produce and accumulate GA and 3HGA when Lys catabolism is stressed.	Lysine	101-104	glutaryl-Coenzyme A dehydrogenase	Mus musculus	12-16
35574370-2	2022	Here, we found that lncRNA PRADX was overexpressed in the mesenchymal GBM and was transcriptionally regulated by RUNX1-CBFbeta complex, overexpressed PRADX suppressed BLCAP expression via interacting with EZH2 and catalyzing trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	243-249	BLCAP apoptosis inducing factor	Homo sapiens	167-172
26101372-6	2015	Ube2W targets multiple TRIM5alpha internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal amino group, which is instead alphaN-acetylated in cells.	Lysine	43-50	ubiquitin conjugating enzyme E2 W	Homo sapiens	0-5
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	Janus kinase 2	Bos taurus	34-38
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	signal transducer and activator of transcription 5B	Bos taurus	229-235
18299392-3	2008	The bidirectional silencing property of Kcnq1ot1 maps to a highly conserved repeat motif within the silencing domain, which directs transcriptional silencing by interaction with chromatin, resulting in histone H3 lysine 9 trimethylation.	Lysine	213-219	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	40-48
35449131-3	2022	Here, we identify that SNIP1 is a non-histone substrate of lysine methyltransferase KMT5A, which undergoes KMT5A-mediated mono-methylation to promote breast cancer cell growth, invasion and lung metastasis.	Lysine	59-65	lysine methyltransferase 5A	Homo sapiens	84-89
18488021-3	2008	Here we report that the HECT-domain ubiquitin ligase Huwe1 ubiquitinates the N-Myc oncoprotein through Lys 48-mediated linkages and targets it for destruction by the proteasome.	Lysine	103-106	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	77-82
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Lysine	164-167	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Lysine	168-171	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
18400224-2	2008	A novel breakdown product arising from the hydrolysis of water buffalo beta-casein, originated by the presence of a plasmin-sensitive Lys bond at position 68 was identified, which was not present in bovine beta-casein.	Lysine	134-137	plasminogen	Bos taurus	116-123
35449131-3	2022	Here, we identify that SNIP1 is a non-histone substrate of lysine methyltransferase KMT5A, which undergoes KMT5A-mediated mono-methylation to promote breast cancer cell growth, invasion and lung metastasis.	Lysine	59-65	lysine methyltransferase 5A	Homo sapiens	107-112
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Lysine	168-171	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Lysine	168-171	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Lysine	114-120	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	147-152
18493325-1	2008	BACKGROUND: Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early embryogenesis.	Lysine	131-137	ring finger protein 2	Mus musculus	61-67
18493325-1	2008	BACKGROUND: Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early embryogenesis.	Lysine	131-137	ring finger protein 2	Mus musculus	68-72
26159421-6	2015	LSD depletion increases trimethylation of histone 3 lysine 4 at the avian myelocytomatosis viral oncogene homolog (MYC) locus, which elevates MYC expression.	Lysine	52-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-118
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Lysine	114-120	angiotensin converting enzyme 2	Homo sapiens	298-302
26159421-6	2015	LSD depletion increases trimethylation of histone 3 lysine 4 at the avian myelocytomatosis viral oncogene homolog (MYC) locus, which elevates MYC expression.	Lysine	52-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-145
18389226-0	2008	CE-LIF determination of salivary cadaverine and lysine concentration ratio as an indicator of lysine decarboxylase enzyme activity.	Lysine	48-54	LIF interleukin 6 family cytokine	Homo sapiens	3-6
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Lysine	0-6	angiotensin converting enzyme 2	Homo sapiens	66-70
18029035-4	2008	Ymer, which has been reported to be highly phosphorylated on tyrosine residues via EGF stimulation, bound to lysine (K)-63-linked polyubiquitin chain on receptor-interacting serine/threonine-protein kinase 1 (RIP1), which is essential for NF-kappaB signaling in collaboration with A20.	Lysine	109-115	receptor interacting serine/threonine kinase 1	Homo sapiens	153-207
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Lysine	0-6	angiotensin converting enzyme 2	Homo sapiens	194-198
18029035-4	2008	Ymer, which has been reported to be highly phosphorylated on tyrosine residues via EGF stimulation, bound to lysine (K)-63-linked polyubiquitin chain on receptor-interacting serine/threonine-protein kinase 1 (RIP1), which is essential for NF-kappaB signaling in collaboration with A20.	Lysine	109-115	receptor interacting serine/threonine kinase 1	Homo sapiens	209-213
26085214-1	2015	Among all the E2 ubiquitin-conjugating enzymes, Ubc13, which heterodimerizes with Uev1a, specifically mediates lysine 63 (K63)-linked protein polyubiquitylation, a process that does not lead to proteasomal degradation of its substrates.	Lysine	111-117	ubiquitin conjugating enzyme E2 N	Homo sapiens	48-53
26085214-1	2015	Among all the E2 ubiquitin-conjugating enzymes, Ubc13, which heterodimerizes with Uev1a, specifically mediates lysine 63 (K63)-linked protein polyubiquitylation, a process that does not lead to proteasomal degradation of its substrates.	Lysine	111-117	ubiquitin conjugating enzyme E2 V1	Homo sapiens	82-87
35458513-6	2022	However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations.	Lysine	24-30	angiotensin converting enzyme 2	Homo sapiens	161-165
35453408-5	2022	A decreased interaction between sirtuin 3 and superoxide dismutase 2 (SOD2) induced SOD2 acetylation on lysine 68 and inactivation, leading to mitochondrial oxidative stress and dysfunction and hypertrophy after 24 h of Iso treatment.	Lysine	104-110	superoxide dismutase 2	Homo sapiens	46-68
18340008-4	2008	Using amino acid sequencing analysis, we identified a major cleavage site between Lys(168) and Leu(169) and a minor cleavage site between Lys(170) and Met(171) in mouse Angptl4.	Lysine	82-85	angiopoietin-like 4	Mus musculus	169-176
18340008-4	2008	Using amino acid sequencing analysis, we identified a major cleavage site between Lys(168) and Leu(169) and a minor cleavage site between Lys(170) and Met(171) in mouse Angptl4.	Lysine	138-141	angiopoietin-like 4	Mus musculus	169-176
35453408-5	2022	A decreased interaction between sirtuin 3 and superoxide dismutase 2 (SOD2) induced SOD2 acetylation on lysine 68 and inactivation, leading to mitochondrial oxidative stress and dysfunction and hypertrophy after 24 h of Iso treatment.	Lysine	104-110	superoxide dismutase 2	Homo sapiens	70-74
25889751-0	2015	Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys(145)-Lys(146) internally cleaved forms.	Lysine	101-104	kallikrein related peptidase 3	Homo sapiens	71-74
25889751-0	2015	Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys(145)-Lys(146) internally cleaved forms.	Lysine	110-113	kallikrein related peptidase 3	Homo sapiens	44-69
18292211-0	2008	Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?	Lysine	79-85	carboxypeptidase M	Homo sapiens	0-18
35453408-5	2022	A decreased interaction between sirtuin 3 and superoxide dismutase 2 (SOD2) induced SOD2 acetylation on lysine 68 and inactivation, leading to mitochondrial oxidative stress and dysfunction and hypertrophy after 24 h of Iso treatment.	Lysine	104-110	superoxide dismutase 2	Homo sapiens	84-88
18292211-1	2008	Carboxypeptidase M (CPM) is a membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins.	Lysine	129-135	carboxypeptidase M	Homo sapiens	0-18
25889751-0	2015	Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys(145)-Lys(146) internally cleaved forms.	Lysine	110-113	kallikrein related peptidase 3	Homo sapiens	71-74
25889751-3	2015	Assay of one of the kallikrein forms, intact free PSA (fPSA-I), is based on a unique monoclonal antibody (4D4), which is specific for PSA without the internal cleavage at Lys(145)-Lys(146).	Lysine	180-183	kallikrein related peptidase 3	Homo sapiens	50-53
18292211-7	2008	We suggest that cleavage of the C-terminal lysine residue of SDF-1alpha by CPM leads to attenuated chemotactic responses and could facilitate G-CSF-induced mobilization of HSPC from BM to peripheral blood.	Lysine	43-49	colony stimulating factor 3	Homo sapiens	142-147
35388001-4	2022	Here we show that depletion of STAG2 in melanoma cells leads to expansion of topologically associating domains (TADs) and enhances the formation of acetylated histone H3 lysine 27 (H3K27ac)-associated DNA loops at sites where binding of STAG2 is switched to its paralog STAG1.	Lysine	170-176	stromal antigen 2	Homo sapiens	31-36
18434530-2	2008	Utx (ubiquitously transcribed tetratricopeptide repeat gene on X chromosome) is an escapee gene that encodes a demethylase specific for lysine 27 of histone H3, a mark of repressed chromatin.	Lysine	136-142	lysine (K)-specific demethylase 6A	Mus musculus	0-3
18434530-8	2008	This transcriptional divergence between the two paralogues was associated with high levels of histone H3 lysine 4 dimethylation at the Utx promoter and of histone H4 lysine 16 acetylation throughout the gene body, which suggests that epigenetic mechanisms control differential expression of paralogous genes.	Lysine	105-111	lysine (K)-specific demethylase 6A	Mus musculus	135-138
25977460-10	2015	JVZ-007-c-myc-his was conjugated to 2-(4-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (p-SCN-DTPA) via the lysines, whereas JVZ-007-cys was conjugated to maleimide-DTPA via the C-terminal cysteine.	Lysine	119-126	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	8-13
25977460-16	2015	Renal uptake of (111)In-JVZ-007-c-myc-his was initially high but was efficiently reduced by coinjection of gelofusine and lysine.	Lysine	122-128	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	32-37
35388001-4	2022	Here we show that depletion of STAG2 in melanoma cells leads to expansion of topologically associating domains (TADs) and enhances the formation of acetylated histone H3 lysine 27 (H3K27ac)-associated DNA loops at sites where binding of STAG2 is switched to its paralog STAG1.	Lysine	170-176	stromal antigen 2	Homo sapiens	237-242
18201968-7	2008	We also found that suppression of STAT3, Oct-3/4, or Eed causes induction of differentiation-associated genes as well as loss of Lys(27)-trimethylated histone H3 at the promoter regions of the differentiation-associated genes.	Lysine	129-132	embryonic ectoderm development	Mus musculus	53-56
35119862-4	2022	Both CBP and p300 contain a domain of about 110 residues (called the bromodomain) that recognizes histone tails with one or more acetylated lysine side chains.	Lysine	140-146	E1A binding protein p300	Homo sapiens	13-17
18307322-6	2008	Sequence alignments of rhuMAb with 12 other recombinant monoclonal antibodies and computer modeling of the Fab part of rhuMAb suggest that the unusually high level of glycation of lysine residue 49, which is located adjacent to the second complementarity-determining region (CDR2) in the light chain, is due to a spatial proximity effect in catalyzing the Amadori rearrangement by aspartic acid residue 31 in the CDR1 on the light chain.	Lysine	180-186	FA complementation group B	Homo sapiens	107-110
18307322-6	2008	Sequence alignments of rhuMAb with 12 other recombinant monoclonal antibodies and computer modeling of the Fab part of rhuMAb suggest that the unusually high level of glycation of lysine residue 49, which is located adjacent to the second complementarity-determining region (CDR2) in the light chain, is due to a spatial proximity effect in catalyzing the Amadori rearrangement by aspartic acid residue 31 in the CDR1 on the light chain.	Lysine	180-186	cerebellar degeneration related protein 1	Homo sapiens	413-417
25755154-0	2015	Lysine methylation modulates the protein-protein interactions of yeast cytochrome C Cyc1p.	Lysine	0-6	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	84-89
25755154-6	2015	Specifically, we asked whether Ctm1p-mediated trimethylation of yeast cytochrome c Cyc1p, on lysine 78, modulates its interactions with Erv1p, Ccp1p, Cyc2p and Cyc3p.	Lysine	93-99	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	83-88
25755154-7	2015	We show that the interactions between Cyc1p and Erv1p, and between Cyc1p and Cyc3p, are significantly increased upon trimethylation of lysine 78.	Lysine	135-141	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	38-43
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	Lysine	92-95	NIMA (never in mitosis gene a)-related expressed kinase 7	Mus musculus	52-56
25755154-7	2015	We show that the interactions between Cyc1p and Erv1p, and between Cyc1p and Cyc3p, are significantly increased upon trimethylation of lysine 78.	Lysine	135-141	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	48-53
25755154-7	2015	We show that the interactions between Cyc1p and Erv1p, and between Cyc1p and Cyc3p, are significantly increased upon trimethylation of lysine 78.	Lysine	135-141	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	67-72
18178582-9	2008	These results suggest that acetylation of Lys-317 modulates the functions of p53 and influences the cross-talk between the DNA damage response and other signaling pathways.	Lysine	42-45	transformation related protein 53, pseudogene	Mus musculus	77-80
35149670-6	2022	However, ISGylation-induced pro-YAP effects were abolished by YAP K497R (K, lysine; R, arginine) mutation, suggesting K497 could be the major YAP ISGylation site.	Lysine	76-82	Yes1 associated transcriptional regulator	Homo sapiens	32-35
18358809-5	2008	Despite the ability of FoxA1 to bind nucleosomes, its differential binding to chromatin sites is dependent on the distribution of histone H3 lysine 4 dimethylation.	Lysine	141-147	forkhead box A1	Homo sapiens	23-28
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	helicase like transcription factor	Homo sapiens	23-27
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	ubiquitin conjugating enzyme E2 V2	Homo sapiens	73-77
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	ubiquitin conjugating enzyme E2 N	Homo sapiens	78-83
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	proliferating cell nuclear antigen	Homo sapiens	176-210
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	helicase like transcription factor	Homo sapiens	23-27
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	ubiquitin conjugating enzyme E2 V2	Homo sapiens	73-77
25944903-5	2015	Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32.	Lysine	16-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	30-35
25944903-5	2015	Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32.	Lysine	16-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	44-49
25944903-5	2015	Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32.	Lysine	16-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	44-49
25911107-7	2015	By in vitro motility assay, we found that lysine acetylation increased the actin-sliding velocity of alpha-myosin by 20% and beta-myosin by 36% compared with their respective non-acetylated isoforms.	Lysine	42-48	myosin heavy chain 14	Homo sapiens	107-113
25911107-9	2015	During induction of hypertrophy, myosin isoform acetylation increased progressively with duration of stress stimuli independently of isoform shift, suggesting that lysine acetylation of myosin could be an early response of myofilaments to increase contractile performance of the heart.	Lysine	164-170	myosin heavy chain 14	Homo sapiens	33-39
25911107-9	2015	During induction of hypertrophy, myosin isoform acetylation increased progressively with duration of stress stimuli independently of isoform shift, suggesting that lysine acetylation of myosin could be an early response of myofilaments to increase contractile performance of the heart.	Lysine	164-170	myosin heavy chain 14	Homo sapiens	186-192
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	ubiquitin conjugating enzyme E2 N	Homo sapiens	78-83
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	proliferating cell nuclear antigen	Homo sapiens	176-210
18212060-4	2008	EGF in the presence of dihydrotestosterone stabilizes the AR-MAGE complex through the site-specific phosphorylation of MAGE-11 at Thr-360 and ubiquitinylation at Lys-240 and Lys-245.	Lysine	162-165	epidermal growth factor	Homo sapiens	0-3
35149670-6	2022	However, ISGylation-induced pro-YAP effects were abolished by YAP K497R (K, lysine; R, arginine) mutation, suggesting K497 could be the major YAP ISGylation site.	Lysine	76-82	Yes1 associated transcriptional regulator	Homo sapiens	62-65
18212060-4	2008	EGF in the presence of dihydrotestosterone stabilizes the AR-MAGE complex through the site-specific phosphorylation of MAGE-11 at Thr-360 and ubiquitinylation at Lys-240 and Lys-245.	Lysine	174-177	epidermal growth factor	Homo sapiens	0-3
35172032-0	2022	Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis.	Lysine	94-100	3-phosphoinositide dependent protein kinase 1	Mus musculus	150-155
17166629-4	2008	In addition, one control case had MDA-Lys-modified alpha-synuclein in the frontal cortex, and another in the substantia nigra.	Lysine	38-41	synuclein alpha	Homo sapiens	51-66
26051938-5	2015	Inhibition of AURKB induces silencing of cenRNA transcription and establishment of a repressive chromatin state with histone H3 lysine 9 trimethylation and heterochromatin protein 1 accumulation.	Lysine	128-134	aurora kinase B	Mus musculus	14-19
25934149-0	2015	Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.	Lysine	0-6	DNA ligase 4	Homo sapiens	93-106
35217833-7	2022	Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1-TAK1-TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-kappaB) signaling pathway.	Lysine	114-117	mitogen-activated protein kinase kinase kinase 7	Mus musculus	193-197
25893304-6	2015	Mechanistically, LSD1 promotes beta-catenin activation by inhibiting the expression of several suppressors of beta-catenin signaling, especially Prickle1 and APC in Lgr5(+) CICs, by directly regulating the levels of mono- and di-methylation of histone H3 lysine-4 at the promoters of these genes.	Lysine	255-261	catenin beta 1	Homo sapiens	31-43
17965877-4	2008	In MDCK cells, AQP2-E258K mainly localized to MVB/lysosomes (Lys).	Lysine	61-64	aquaporin 2	Canis lupus familiaris	15-19
35217833-7	2022	Mechanistically, we demonstrated that TRIM45 constitutively interacted with TAB2 and consequently facilitated the Lys-63-linked polyubiquitination of TAB2, leading to the formation of the TAB1-TAK1-TAB2 complex and activation of TAK1, which was ultimately followed by activation of the nuclear factor-kappa B (NF-kappaB) signaling pathway.	Lysine	114-117	mitogen-activated protein kinase kinase kinase 7	Mus musculus	229-233
17965877-10	2008	Instead, our data reveal that the loss of the E258 in AQP2-E258K is fundamental to its missorting to MVB/Lys and indicate that this amino acid has an important role in the proper structure formation of the C-terminal tail of AQP2.	Lysine	105-108	aquaporin 2	Canis lupus familiaris	54-58
17965877-10	2008	Instead, our data reveal that the loss of the E258 in AQP2-E258K is fundamental to its missorting to MVB/Lys and indicate that this amino acid has an important role in the proper structure formation of the C-terminal tail of AQP2.	Lysine	105-108	aquaporin 2	Canis lupus familiaris	225-229
25660075-7	2015	We also identified acetylation of K338/K341 lysine residues in OGG1 has an important role on the repair activity of OGG1 to oxidative damage after H2O2 exposure in human lens epithelial cells (HLE-B3).	Lysine	44-50	8-oxoguanine DNA glycosylase	Homo sapiens	63-67
35094088-1	2022	Sotos syndrome (SS), the most common overgrowth with intellectual disability (OGID) disorder, is caused by inactivating germline mutations of NSD1, which encodes a histone H3 lysine 36 methyltransferase.	Lysine	175-181	nuclear receptor binding SET domain protein 1	Homo sapiens	142-146
25660075-7	2015	We also identified acetylation of K338/K341 lysine residues in OGG1 has an important role on the repair activity of OGG1 to oxidative damage after H2O2 exposure in human lens epithelial cells (HLE-B3).	Lysine	44-50	8-oxoguanine DNA glycosylase	Homo sapiens	116-120
18155658-5	2008	Surprisingly, HBX in which all six lysines were mutated and showed no evidence of ubiquitination, was still susceptible to proteasomal degradation.	Lysine	35-42	X protein	Hepatitis B virus	14-17
35163434-5	2022	The serine-threonine kinase WNK3 (also known as protein kinase lysine-deficient 3) was identified as the most promising target of CSA with the strongest enzymatic activity inhibition in vitro and the highest binding affinity in molecular docking in silico.	Lysine	63-69	WNK lysine deficient protein kinase 3	Homo sapiens	28-32
18280244-6	2008	We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60.	Lysine	57-63	transformation related protein 53, pseudogene	Mus musculus	79-82
18280244-6	2008	We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60.	Lysine	57-63	transformation related protein 53, pseudogene	Mus musculus	110-113
18280244-6	2008	We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60.	Lysine	57-63	transformation related protein 53, pseudogene	Mus musculus	110-113
18006692-10	2008	His107 (EC2-BRS-3) for lysine (H107K) (EC2-GRPR) decreased affinity (25- and 0-fold) for peptides 4 and 1; however, it could not be activated by either peptide.	Lysine	23-29	transcription factor 15	Homo sapiens	8-11
18006692-10	2008	His107 (EC2-BRS-3) for lysine (H107K) (EC2-GRPR) decreased affinity (25- and 0-fold) for peptides 4 and 1; however, it could not be activated by either peptide.	Lysine	23-29	transcription factor 15	Homo sapiens	39-42
25817234-3	2015	MAIN METHODS: MCP-1 gene expression was measured by Real-Time quantitative Polymerase Chain Reaction (RT-qPCR), the histone 3 lysine 4 methylation (H3K4me) and lysine 9 methylation (H3K9me) were evaluated using chromatin immunoprecipitation assay.	Lysine	160-166	C-C motif chemokine ligand 2	Homo sapiens	14-19
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	catenin beta 1	Homo sapiens	132-144
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	catenin beta 1	Homo sapiens	191-203
35116104-4	2022	BET inhibitors, disrupting the interaction between BET proteins and acetylated lysines, have been reported to suppress tumor initiation and progression in most of GI cancers.	Lysine	79-86	delta/notch like EGF repeat containing	Homo sapiens	0-3
18034266-11	2008	Still, we show that Su(z)12 is essential for tri-methylation of the lysine 27 residue of histone H3 in vivo, and that overexpression of SU(Z)12 in somatic clones results in higher levels of histone methylation, indicating that SU(Z)12 is rate limiting for the enzymatic activity of PRC2.	Lysine	68-74	Su(z)12	Drosophila melanogaster	20-27
18034266-11	2008	Still, we show that Su(z)12 is essential for tri-methylation of the lysine 27 residue of histone H3 in vivo, and that overexpression of SU(Z)12 in somatic clones results in higher levels of histone methylation, indicating that SU(Z)12 is rate limiting for the enzymatic activity of PRC2.	Lysine	68-74	Su(z)12	Drosophila melanogaster	136-143
35116104-4	2022	BET inhibitors, disrupting the interaction between BET proteins and acetylated lysines, have been reported to suppress tumor initiation and progression in most of GI cancers.	Lysine	79-86	delta/notch like EGF repeat containing	Homo sapiens	51-54
25997738-2	2015	Here, we elucidate the functions of two histone H3 lysine 4 (H3K4) methylation enzymes, SMYD3 and SETD7, during zebrafish heart morphogenesis using gene expression profiling by whole mount in situ hybridization and antisense morpholino oligonucleotide (MO)-based gene knockdown.	Lysine	51-57	SET domain containing 7, histone lysine methyltransferase	Danio rerio	98-103
34974819-1	2022	The p300 histone acetyltransferase (HAT) enzyme acetylates the lysine residue of histone promotes the transcription reaction.	Lysine	63-69	E1A binding protein p300	Homo sapiens	4-8
25825497-8	2015	LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys(370) at submicromolar concentrations.	Lysine	92-95	SET and MYND domain containing 2	Homo sapiens	55-60
18086704-0	2008	Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells.	Lysine	26-32	myocyte enhancer factor 2C	Homo sapiens	56-61
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	42-48	nucleotide binding oligomerization domain containing 1	Homo sapiens	135-139
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	83-89	nucleotide binding oligomerization domain containing 1	Homo sapiens	135-139
2478364-3	1989	This was characterized by the extent to which a polysaccharide could protect chemical modification of Lys-125 and Lys-136, two lysyl residues of antithrombin which have been implicated in heparin binding.	Lysine	102-105	serpin family C member 1	Homo sapiens	145-157
18224408-6	2008	These enzymatic activities, including RNA polymerase II phosphorylation as well as histone H3 lysine 79 methylation present attractive targets for the development of future MLL-directed therapy.	Lysine	94-100	lysine methyltransferase 2A	Homo sapiens	173-176
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Lysine	29-32	MLO-like protein 4	Zea mays	58-62
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Lysine	29-32	MLO-like protein 4	Zea mays	124-128
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Lysine	29-32	MLO-like protein 4	Zea mays	124-128
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Lysine	84-87	MLO-like protein 4	Zea mays	58-62
17928567-8	2008	Dimeric histaprodifen was docked into the binding pocket of gpH(1)R. Hydrogen bonds and electrostatic interactions were detected between dimeric histaprodifen and Asp-116, Ser-120, Lys-187, Glu-190, and Tyr-432.	Lysine	181-184	gephyrin	Homo sapiens	60-63
17967868-0	2008	The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.	Lysine	68-74	males absent on the first	Drosophila melanogaster	37-40
17967868-1	2008	The mammalian ortholog of the Drosophila MOF (males absent on the first) gene product is a histone H4 lysine 16-specific acetyltransferase.	Lysine	102-108	males absent on the first	Drosophila melanogaster	41-44
17967868-1	2008	The mammalian ortholog of the Drosophila MOF (males absent on the first) gene product is a histone H4 lysine 16-specific acetyltransferase.	Lysine	102-108	males absent on the first	Drosophila melanogaster	46-71
18923646-4	2008	To further investigate the role of ubiquitination in regulating G-CSFR signaling, we generated a mutant form of the G-CSFR (K762R/G-CSFR) which abrogates the attachment of ubiquitin to the lysine residue at position 762 of the G-CSFR that is deleted in the Delta716 G-CSFR form isolated from patients with SCN/AML.	Lysine	189-195	colony stimulating factor 3 receptor	Homo sapiens	116-122
18923646-4	2008	To further investigate the role of ubiquitination in regulating G-CSFR signaling, we generated a mutant form of the G-CSFR (K762R/G-CSFR) which abrogates the attachment of ubiquitin to the lysine residue at position 762 of the G-CSFR that is deleted in the Delta716 G-CSFR form isolated from patients with SCN/AML.	Lysine	189-195	colony stimulating factor 3 receptor	Homo sapiens	116-122
18923646-4	2008	To further investigate the role of ubiquitination in regulating G-CSFR signaling, we generated a mutant form of the G-CSFR (K762R/G-CSFR) which abrogates the attachment of ubiquitin to the lysine residue at position 762 of the G-CSFR that is deleted in the Delta716 G-CSFR form isolated from patients with SCN/AML.	Lysine	189-195	colony stimulating factor 3 receptor	Homo sapiens	116-122
18923646-9	2008	Mutations that disrupt G-CSFR ubiquitination at lysine 762 induce aberrant receptor signaling and hyperproliferative responses to G-CSF, which may contribute to leukemic transformation.	Lysine	48-54	colony stimulating factor 3 receptor	Homo sapiens	23-29
18923646-9	2008	Mutations that disrupt G-CSFR ubiquitination at lysine 762 induce aberrant receptor signaling and hyperproliferative responses to G-CSF, which may contribute to leukemic transformation.	Lysine	48-54	colony stimulating factor 3	Homo sapiens	23-28
18027980-1	2007	Sir2 protein deacetylases (or sirtuins) catalyze NAD+-dependent conversion of epsilon-amino-acetylated lysine residues to deacetylated lysine, nicotinamide, and 2"-O-acetyl-ADP-ribose.	Lysine	103-109	sirtuin 2	Homo sapiens	0-4
18027980-1	2007	Sir2 protein deacetylases (or sirtuins) catalyze NAD+-dependent conversion of epsilon-amino-acetylated lysine residues to deacetylated lysine, nicotinamide, and 2"-O-acetyl-ADP-ribose.	Lysine	135-141	sirtuin 2	Homo sapiens	0-4
17855633-5	2007	Purified EAP showed a histone H3 lysine 79-specific methylase activity, displayed a robust RNAPolII CTD kinase function, and counteracted the effect of the pTEFb inhibitor 5,6-dichloro-benzimidazole-riboside.	Lysine	33-39	ribosomal protein L22	Homo sapiens	9-12
18033247-0	2007	RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.	Lysine	35-41	recombination activating 2	Homo sapiens	0-4
18033247-4	2007	Here we show that RAG2--an essential component of the RAG1/2 V(D)J recombinase, which mediates antigen-receptor gene assembly--contains a plant homeodomain (PHD) finger that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3).	Lysine	226-232	recombination activating 2	Homo sapiens	18-22
17928536-0	2007	Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.	Lysine	93-99	sodium voltage-gated channel alpha subunit 5	Homo sapiens	70-77
18025461-0	2007	The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.	Lysine	78-84	recombination activating 2	Homo sapiens	32-36
18025461-2	2007	RAG2 contains a plant homeodomain (PHD) near its C terminus (RAG2-PHD) that recognizes histone H3 methylated at lysine 4 (H3K4me) and influences V(D)J recombination.	Lysine	112-118	recombination activating 2	Homo sapiens	0-4
18025461-2	2007	RAG2 contains a plant homeodomain (PHD) near its C terminus (RAG2-PHD) that recognizes histone H3 methylated at lysine 4 (H3K4me) and influences V(D)J recombination.	Lysine	112-118	recombination activating 2	Homo sapiens	61-65
17965779-6	2007	This coactivator function of atrogin-1 was dependent on its ubiquitin ligase activity and the deposition of polyubiquitin chains on lysine 63 of Foxo1 and Foxo3a.	Lysine	132-138	F-box protein 32	Mus musculus	29-38
17965779-6	2007	This coactivator function of atrogin-1 was dependent on its ubiquitin ligase activity and the deposition of polyubiquitin chains on lysine 63 of Foxo1 and Foxo3a.	Lysine	132-138	forkhead box O1	Mus musculus	145-150
17965779-8	2007	These experiments define a role for lysine 63-linked ubiquitin chains in transcriptional coactivation and demonstrate that atrogin-1 uses this mechanism to disrupt physiologic cardiac hypertrophic signaling through its effects on Forkhead transcription factors.	Lysine	36-42	F-box protein 32	Mus musculus	123-132
17929852-2	2007	Furthermore, p33ING1 is a transcriptional silencer that recognizes the histone mark for trimethylated lysine 4 at histone H3.	Lysine	102-108	inhibitor of growth family member 1	Homo sapiens	13-20
17823124-0	2007	Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.	Lysine	103-106	TANK binding kinase 1	Homo sapiens	77-81
17823124-0	2007	Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.	Lysine	103-106	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	82-92
17823124-5	2007	Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.	Lysine	173-176	TANK binding kinase 1	Homo sapiens	49-53
17935739-9	2007	Pre-treatment with Wortmannin, LY 294002, PD 098,059 and SB 203580 caused a significant decrease in nitrite production, NOS type II protein expression and NOS type II mRNA expression induced by leptin and interferon-gamma co-stimulation.	Lysine	31-33	leptin	Mus musculus	194-200
17709375-0	2007	Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.	Lysine	28-34	ubiquitin conjugating enzyme E2 N	Homo sapiens	74-79
17709375-0	2007	Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.	Lysine	28-34	ubiquitin conjugating enzyme E2 V1	Homo sapiens	80-85
17709375-4	2007	We have determined that the presentation of Lys(63) of ubiquitin by UEV1A suppresses TRAF6 modification.	Lysine	44-47	ubiquitin conjugating enzyme E2 V1	Homo sapiens	68-73
17709375-4	2007	We have determined that the presentation of Lys(63) of ubiquitin by UEV1A suppresses TRAF6 modification.	Lysine	44-47	TNF receptor associated factor 6	Homo sapiens	85-90
17709375-5	2007	Based on our observations, we propose that the modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism.	Lysine	77-80	ubiquitin conjugating enzyme E2 V1	Homo sapiens	126-131
17709375-5	2007	Based on our observations, we propose that the modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism.	Lysine	77-80	ubiquitin conjugating enzyme E2 V1	Homo sapiens	171-176
17709375-5	2007	Based on our observations, we propose that the modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism.	Lysine	187-190	ubiquitin conjugating enzyme E2 V1	Homo sapiens	171-176
17597201-4	2007	The carboxylated CarboSil can then be used to immobilize TM through the formation of an amide bond between the surface carboxylic acid groups and the lysine residues of TM.	Lysine	150-156	thrombomodulin	Homo sapiens	57-59
17597201-4	2007	The carboxylated CarboSil can then be used to immobilize TM through the formation of an amide bond between the surface carboxylic acid groups and the lysine residues of TM.	Lysine	150-156	thrombomodulin	Homo sapiens	169-171
17879145-1	2007	Glutaryl-CoA dehydrogenase (GCDH) is a central enzyme in the catabolic pathway of L-tryptophan, L-lysine, and L-hydroxylysine which catalyses the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2.	Lysine	96-104	glutaryl-CoA dehydrogenase	Homo sapiens	0-26
17879145-1	2007	Glutaryl-CoA dehydrogenase (GCDH) is a central enzyme in the catabolic pathway of L-tryptophan, L-lysine, and L-hydroxylysine which catalyses the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2.	Lysine	96-104	glutaryl-CoA dehydrogenase	Homo sapiens	28-32
17646389-2	2007	Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53.	Lysine	29-35	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	66-72
17646389-2	2007	Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53.	Lysine	29-35	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	88-92
17646389-2	2007	Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53.	Lysine	29-35	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	97-101
17880717-2	2007	In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4.	Lysine	88-94	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	55-60
17785417-6	2007	SIRT1-induced increase in endothelial NO is mediated through lysines 496 and 506 in the calmodulin-binding domain of eNOS.	Lysine	61-68	sirtuin 1	Mus musculus	0-5
17785417-6	2007	SIRT1-induced increase in endothelial NO is mediated through lysines 496 and 506 in the calmodulin-binding domain of eNOS.	Lysine	61-68	nitric oxide synthase 3, endothelial cell	Mus musculus	117-121
17803944-3	2007	Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --&gt; lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3.	Lysine	110-116	Sac3p	Saccharomyces cerevisiae S288C	197-201
17803944-3	2007	Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --&gt; lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3.	Lysine	110-116	bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase	Saccharomyces cerevisiae S288C	203-208
17760996-6	2007	The histone acetyltransferase GCN5 can acetylate the Drosophila remodelling ATPase ISWI at a single, conserved lysine, K753, in vivo and in vitro.	Lysine	111-117	Gcn5 acetyltransferase	Drosophila melanogaster	30-34
17760996-6	2007	The histone acetyltransferase GCN5 can acetylate the Drosophila remodelling ATPase ISWI at a single, conserved lysine, K753, in vivo and in vitro.	Lysine	111-117	Imitation SWI	Drosophila melanogaster	83-87
17760996-7	2007	The target sequence is strikingly similar to the N-terminus of histone H3, where the corresponding lysine, H3K14, can also be acetylated by GCN5.	Lysine	99-105	Gcn5 acetyltransferase	Drosophila melanogaster	140-144
17583737-0	2007	Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.	Lysine	136-144	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	21-56
17583737-2	2007	Plants use a shortcut of a bacterial pathway to l-Lysine in which the pyridoxal-5"-phosphate (PLP)-dependent enzyme ll-diaminopimelate aminotransferase (LL-DAP-AT) transforms l-tetrahydrodipicolinic acid (L-THDP) directly to LL-DAP.	Lysine	48-56	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	116-151
17583737-2	2007	Plants use a shortcut of a bacterial pathway to l-Lysine in which the pyridoxal-5"-phosphate (PLP)-dependent enzyme ll-diaminopimelate aminotransferase (LL-DAP-AT) transforms l-tetrahydrodipicolinic acid (L-THDP) directly to LL-DAP.	Lysine	48-56	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	153-162
17707224-3	2007	Two lysines are found to be automethylated in G9a, and one is H3K9-like and can establish a docking site for HP1 chromodomain.	Lysine	4-11	chromobox 5	Homo sapiens	109-112
17707229-1	2007	MLL-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription.	Lysine	49-55	lysine methyltransferase 2A	Homo sapiens	0-3
17707231-4	2007	As with methylation of H3 lysine 9, autocatalytic G9a methylation is necessary and sufficient to mediate in vivo interaction with the epigenetic regulator heterochromatin protein 1 (HP1), and this methyl-dependent interaction can be reversed by adjacent G9a phosphorylation.	Lysine	26-32	chromobox 5	Homo sapiens	155-180
17707231-4	2007	As with methylation of H3 lysine 9, autocatalytic G9a methylation is necessary and sufficient to mediate in vivo interaction with the epigenetic regulator heterochromatin protein 1 (HP1), and this methyl-dependent interaction can be reversed by adjacent G9a phosphorylation.	Lysine	26-32	chromobox 5	Homo sapiens	182-185
17707231-5	2007	NMR analysis indicates that the HP1 chromodomain recognizes methyl-G9a through a binding mode similar to that used in recognition of methyl-H3K9, demonstrating that the chromodomain functions as a generalized methyl-lysine binding module.	Lysine	216-222	chromobox 5	Homo sapiens	32-35
17544373-5	2007	Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus.	Lysine	153-159	piwi like RNA-mediated gene silencing 4	Homo sapiens	26-37
17544373-5	2007	Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus.	Lysine	153-159	piwi like RNA-mediated gene silencing 4	Homo sapiens	39-45
17544230-6	2007	Under the same experimental condition, lysine to arginine substitution of histone H3 at position 36 abolished the methyltransferase activity of Drosophila ASH1, suggesting that K36 is their specific target.	Lysine	39-45	absent, small, or homeotic discs 1	Drosophila melanogaster	155-159
17483134-6	2007	Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule.	Lysine	108-114	transmembrane immune signaling adaptor TYROBP	Homo sapiens	58-89
17525163-5	2007	Sumoylation of Oct4 occurs at a single lysine, Lys(118), located at the end of the amino-terminal transactivation domain and next to the Pit1-Oct-Unc86 (POU) DNA binding domain.	Lysine	39-45	POU class 5 homeobox 1	Homo sapiens	15-19
17525163-5	2007	Sumoylation of Oct4 occurs at a single lysine, Lys(118), located at the end of the amino-terminal transactivation domain and next to the Pit1-Oct-Unc86 (POU) DNA binding domain.	Lysine	47-50	POU class 5 homeobox 1	Homo sapiens	15-19
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	69-72	ADAM metallopeptidase domain 8	Homo sapiens	139-144
17517887-2	2007	When DNA damage is encountered, PCNA is monoubiquitinated on Lys-164 by the Rad6-Rad18 complex as the initiating step of translesion synthesis.	Lysine	61-64	proliferating cell nuclear antigen	Homo sapiens	32-36
17630853-5	2007	CONCLUSION: The results indicated that XRCC1 codon 194 Trp allele and XPD codon 751 Lys allele may be contributing factors in the risk of NPC.	Lysine	84-87	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	70-73
17579775-4	2007	MJE3 was found to label PGAM1 on lysine-100, a conserved active site residue implicated in substrate recognition.	Lysine	33-39	phosphoglycerate mutase 1	Homo sapiens	24-29
17498659-5	2007	We find that BRD7 bromodomain contains the typical left-handed four-helix bundle topology, and can bind with weak affinity to lysine-acetylated peptides derived from histone H3 with K9 or K14 acetylated and from histone H4 with K8, K12 or K16 acetylated.	Lysine	126-132	bromodomain containing 7	Homo sapiens	13-17
17449872-3	2007	By introducing point mutations into a subdomain interface at the base of the myosin lever arm at positions Lys(84) and Arg(704), we caused modulatory changes in the equilibrium constant of the recovery stroke, which we could accurately resolve using the fluorescence signal of single tryptophan Dictyostelium myosin II constructs.	Lysine	107-110	myosin heavy chain 14	Homo sapiens	77-83
17449872-3	2007	By introducing point mutations into a subdomain interface at the base of the myosin lever arm at positions Lys(84) and Arg(704), we caused modulatory changes in the equilibrium constant of the recovery stroke, which we could accurately resolve using the fluorescence signal of single tryptophan Dictyostelium myosin II constructs.	Lysine	107-110	myosin heavy chain 14	Homo sapiens	309-315
17362920-7	2007	Furthermore, the effect of erythropoietin on reactive oxygen species levels was also blocked by LY 294002.	Lysine	96-98	erythropoietin	Rattus norvegicus	27-41
17439941-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	CDK2 associated cullin domain 1	Homo sapiens	14-20
17554311-5	2007	Here we show that mutations in an Arabidopsis deubiquitination enzyme, SUP32/UBP26, decrease the dimethylation on lysine 9 of H3, suppress siRNA-directed methylation of DNA and release heterochromatic silencing of transgenes as well as transposons.	Lysine	114-120	ubiquitin-specific protease 26	Arabidopsis thaliana	71-76
17554311-5	2007	Here we show that mutations in an Arabidopsis deubiquitination enzyme, SUP32/UBP26, decrease the dimethylation on lysine 9 of H3, suppress siRNA-directed methylation of DNA and release heterochromatic silencing of transgenes as well as transposons.	Lysine	114-120	ubiquitin-specific protease 26	Arabidopsis thaliana	77-82
17554311-6	2007	We found that Arabidopsis histone H2B is monoubiquitinated at lysine 143 and that the levels of ubiquitinated H2B and trimethyl H3 at lysine 4 increase in sup32 mutant plants.	Lysine	62-68	ubiquitin-specific protease 26	Arabidopsis thaliana	155-160
17554311-6	2007	We found that Arabidopsis histone H2B is monoubiquitinated at lysine 143 and that the levels of ubiquitinated H2B and trimethyl H3 at lysine 4 increase in sup32 mutant plants.	Lysine	134-140	ubiquitin-specific protease 26	Arabidopsis thaliana	155-160
17466390-6	2007	Desensitization was impaired by the nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC) and PKG inhibitors L-NAME, LY 83583 and KT5823, respectively, indicating that homologous desensitization of TP alpha involves nitric oxide generation and signalling.	Lysine	123-125	protein kinase cGMP-dependent 1	Homo sapiens	100-103
17264068-6	2007	The variant genotypes of XPD Lys751Gln polymorphism were associated with a higher risk of EA; the adjusted OR comparing Gln/Gln + Lys/Gln with Lys/Lys was 1.49 (95% CI: 1.02-2.14).	Lysine	29-32	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
17264068-6	2007	The variant genotypes of XPD Lys751Gln polymorphism were associated with a higher risk of EA; the adjusted OR comparing Gln/Gln + Lys/Gln with Lys/Lys was 1.49 (95% CI: 1.02-2.14).	Lysine	130-133	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
17264068-6	2007	The variant genotypes of XPD Lys751Gln polymorphism were associated with a higher risk of EA; the adjusted OR comparing Gln/Gln + Lys/Gln with Lys/Lys was 1.49 (95% CI: 1.02-2.14).	Lysine	130-133	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
17332144-3	2007	We found a new sequence variation in exon 7 of the CYP2C9 gene (1060G&gt;A) resulting in a substitution of acidic amino acid glutamate to basic lysine (E354K) when translated.	Lysine	144-150	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	51-57
17542647-0	2007	Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27.	Lysine	96-102	like heterochromatin protein (LHP1)	Arabidopsis thaliana	12-16
17542647-0	2007	Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27.	Lysine	96-102	like heterochromatin protein (LHP1)	Arabidopsis thaliana	17-21
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	141-147	like heterochromatin protein (LHP1)	Arabidopsis thaliana	45-49
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	141-147	like heterochromatin protein (LHP1)	Arabidopsis thaliana	50-54
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	141-147	like heterochromatin protein (LHP1)	Arabidopsis thaliana	86-90
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	141-147	like heterochromatin protein (LHP1)	Arabidopsis thaliana	91-95
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	236-242	like heterochromatin protein (LHP1)	Arabidopsis thaliana	45-49
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	236-242	like heterochromatin protein (LHP1)	Arabidopsis thaliana	50-54
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	236-242	like heterochromatin protein (LHP1)	Arabidopsis thaliana	86-90
17542647-5	2007	We investigated the chromatin marks to which TFL2/LHP1 binds and show that, in vitro, TFL2/LHP1 binds to histone H3 di- or tri-methylated at lysine 9 (H3K9me2 or H3K9me3), the marks recognized by HP1, and to histone H3 trimethylated at lysine 27 (H3K27me3), the mark deposited by PRC2.	Lysine	236-242	like heterochromatin protein (LHP1)	Arabidopsis thaliana	91-95
17470536-4	2007	In vitro, methylation of histone 3 Lys 9 by G9a creates a binding platform for HP1alpha, beta, and gamma.	Lysine	35-38	chromobox 5	Homo sapiens	79-87
17254749-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	CDK2 associated cullin domain 1	Homo sapiens	14-20
17254749-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	CDK2 associated cullin domain 1	Homo sapiens	106-112
17339329-2	2007	PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3).	Lysine	103-109	embryonic ectoderm development	Mus musculus	48-51
17447102-1	2007	In Saccharomyces cerevisiae histone H2B is ubiquitylated at lysine 123 in a process requiring the E2-ubiquitin conjugase, Rad6.	Lysine	60-66	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	122-126
17447102-8	2007	Finally, by comparing gene expression changes in the htb1 ( K123R ) strain with those in a strain deleted for rad6, we conclude that lysine 123 affects transcription primarily because of it being a site of ubiquitylation.	Lysine	133-139	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	110-114
17310067-12	2007	Moreover, a RAMP1 mutant lacking the only intracellular lysine (RAMP1K142R) internalized and was degraded normally.	Lysine	56-62	receptor activity modifying protein 1	Homo sapiens	12-17
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	35-41	colony stimulating factor 3 receptor	Homo sapiens	64-110
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	35-41	colony stimulating factor 3 receptor	Homo sapiens	112-118
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	35-41	colony stimulating factor 3	Homo sapiens	112-117
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	251-257	colony stimulating factor 3 receptor	Homo sapiens	64-110
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	251-257	colony stimulating factor 3 receptor	Homo sapiens	112-118
17363902-4	2007	Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine.	Lysine	251-257	colony stimulating factor 3	Homo sapiens	112-117
17391059-7	2007	Of the five potential TRPS1 SUMO-target sites, which were predicted based on a minimal SUMOylation consensus sequence (MCS), two are located within the C-terminal repression domain (RD) at lysine residues 1192 (termed S4) and 1201 (S5).	Lysine	189-195	transcriptional repressor GATA binding 1	Homo sapiens	22-27
17696747-7	2007	Analysis of XPD genotypes revealed 51% Lys/Lys, 41% Lys/Gln and 8% Gln/Gln with Gln allele frequency of 0.29.	Lysine	39-42	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	12-15
17696747-7	2007	Analysis of XPD genotypes revealed 51% Lys/Lys, 41% Lys/Gln and 8% Gln/Gln with Gln allele frequency of 0.29.	Lysine	43-46	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	12-15
17696747-7	2007	Analysis of XPD genotypes revealed 51% Lys/Lys, 41% Lys/Gln and 8% Gln/Gln with Gln allele frequency of 0.29.	Lysine	43-46	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	12-15
17205979-9	2007	Studies of these mutants revealed that trimethylation of Lys(347) of RARalpha facilitated its interactions with cofactors p300/CREB-binding protein-associated factor and receptor-interacting protein 140 as well as its heterodimeric partner retinoid X receptor, suggesting that site-specific hydrophobicity at Lys(347) enhanced molecular interaction of RARalpha with its modulators.	Lysine	57-60	retinoic acid receptor alpha	Homo sapiens	352-360
17205979-9	2007	Studies of these mutants revealed that trimethylation of Lys(347) of RARalpha facilitated its interactions with cofactors p300/CREB-binding protein-associated factor and receptor-interacting protein 140 as well as its heterodimeric partner retinoid X receptor, suggesting that site-specific hydrophobicity at Lys(347) enhanced molecular interaction of RARalpha with its modulators.	Lysine	309-312	retinoic acid receptor alpha	Homo sapiens	69-77
17283066-3	2007	Here, we show that endogenous HIC1 is SUMOylated in vivo on a phylogenetically conserved lysine, K314, located in the central region which is a second repression domain.	Lysine	89-95	HIC ZBTB transcriptional repressor 1	Homo sapiens	30-34
17283066-6	2007	Strikingly, the K314R mutant is less acetylated than wild-type HIC1, suggesting that this lysine is a target for both SUMOylation and acetylation.	Lysine	90-96	HIC ZBTB transcriptional repressor 1	Homo sapiens	63-67
17314413-2	2007	HP1 proteins bind via their chromodomain to nucleosomes methylated at lysine 9 of histone H3 (H3K9me).	Lysine	70-76	chromobox 5	Mus musculus	0-3
17264082-5	2007	Homogeneous apoA-II rHDL were reacted with a cross-linking agent to link proximal lysine residues.	Lysine	82-88	apolipoprotein A2	Homo sapiens	12-19
17392473-5	2007	In neurons, acetylation at lysine 40 of alpha-tubulin increases the flux of vesicles and the subsequent release of BDNF.	Lysine	27-33	tubulin alpha 1b	Homo sapiens	40-53
17392473-7	2007	Our findings reveal that HDAC6 inhibition and acetylation at lysine 40 of alpha-tubulin may be therapeutic targets of interest in disorders such as HD in which intracellular transport is altered.	Lysine	61-67	tubulin alpha 1b	Homo sapiens	74-87
17320161-3	2007	Here we demonstrate that the JARID1 proteins RBP2, PLU1, and SMCX are histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4).	Lysine	136-142	little imaginal discs	Drosophila melanogaster	29-35
17300195-2	2007	In the context of the HoxD9 homeodomain bound specifically to DNA we were able to directly observe three cross-peaks, arising from lysine NH3 groups, with 15N chemical shifts around approximately 33 ppm at pH 5.8 and 35 degrees C. Measurement of water-exchange rates and various types of 15N transverse relaxation rates for these NH3 groups, reveals that rapid water exchange dominates the 15N relaxation for antiphase coherence with respect to 1H through scalar relaxation of the second kind.	Lysine	131-137	homeobox D9	Homo sapiens	22-27
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	13-19	receptor interacting serine/threonine kinase 1	Homo sapiens	48-52
17306544-5	2007	We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism.	Lysine	56-62	receptor interacting serine/threonine kinase 1	Homo sapiens	48-52
17116397-1	2007	Homoisocitrate dehydrogenase is involved in the alpha-aminoadipate pathway of biosynthesis of l-lysine in fungi, yeast, some prokaryotic bacteria, and archaea.	Lysine	94-102	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
17217456-2	2007	The lysine-rich classical AGP subfamily in Arabidopsis consists of three members, AtAGP17, 18 and 19.	Lysine	4-10	arabinogalactan protein 17	Arabidopsis thaliana	82-89
16862177-3	2007	In current models of the functionally similar Skp1, cullin, F-box (SCF)-E3 ligase, the E3 binds the target protein and the E2 catalyses ubiquitin transfer to lysines in an appropriately positioned domain.	Lysine	158-165	S-phase kinase associated protein 1	Homo sapiens	46-50
16862177-3	2007	In current models of the functionally similar Skp1, cullin, F-box (SCF)-E3 ligase, the E3 binds the target protein and the E2 catalyses ubiquitin transfer to lysines in an appropriately positioned domain.	Lysine	158-165	CDK2 associated cullin domain 1	Homo sapiens	52-58
16862185-3	2007	Among four potential SUMO motifs in Ets-1, we identified lysines 15 and 227 within the LK(15)YE and IK(227)QE motifs, as being the sumoylation acceptor sites.	Lysine	57-64	ETS proto-oncogene 1, transcription factor	Homo sapiens	36-41
16862185-6	2007	Finally, sumoylation of Ets-1 leads to reduced transactivation and we demonstrated that previously identified critical lysine residues in Synergistic Control motifs are the sumoylation acceptor sites of Ets-1.	Lysine	119-125	ETS proto-oncogene 1, transcription factor	Homo sapiens	24-29
16862185-6	2007	Finally, sumoylation of Ets-1 leads to reduced transactivation and we demonstrated that previously identified critical lysine residues in Synergistic Control motifs are the sumoylation acceptor sites of Ets-1.	Lysine	119-125	ETS proto-oncogene 1, transcription factor	Homo sapiens	203-208
17202337-6	2007	The lysine residue in the transmembrane region of MAIR-II was involved in the association with FcRgamma chain as well as DAP12.	Lysine	4-10	CD300C molecule 2	Mus musculus	50-57
17218261-5	2007	A lysine mutant of PTEN, K289E associated with Cowden syndrome, retains catalytic activity but fails to accumulate in nuclei of patient tissue due to an import defect.	Lysine	2-8	phosphatase and tensin homolog	Homo sapiens	19-23
17218261-6	2007	We identify this and another lysine residue as major monoubiquitination sites essential for PTEN import.	Lysine	29-35	phosphatase and tensin homolog	Homo sapiens	92-96
18419267-9	2007	BMAL1 is specifically acetylated on a unique, highly conserved Lys-537 residue.	Lysine	63-66	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	0-5
17088384-1	2007	In yeast and other eukaryotes, the histone methyltransferase Set1 mediates methylation of lysine 4 on histone H3 (H3K4me).	Lysine	90-96	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	61-65
17341467-3	2007	Here we describe a short amphipathic peptide, Pep-3, that combines a tryptophan/phenylalanine domain with a lysine/arginine-rich hydrophilic motif.	Lysine	108-114	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	46-51
17056597-5	2006	The synthetic TLR4 peptide corresponding to the TLR4 region Glu(24)-Lys(47) directly binds to recombinant soluble MD-2 (sMD-2).	Lysine	68-71	toll like receptor 4	Homo sapiens	14-18
17056597-5	2006	The synthetic TLR4 peptide corresponding to the TLR4 region Glu(24)-Lys(47) directly binds to recombinant soluble MD-2 (sMD-2).	Lysine	68-71	toll like receptor 4	Homo sapiens	48-52
17056597-9	2006	These results demonstrate that the TLR4 region Glu(24)-Lys(47) is a site for MD-2 binding and that Cys(29) and Cys(40) within this region are critical residues for MD-2 binding and LPS signaling.	Lysine	55-58	toll like receptor 4	Homo sapiens	35-39
17028178-6	2006	A large fraction of the Lys(63) conjugates in ubp2Delta cells bound to Rsp5, and a proteomics approach was used to identify Rsp5 substrates subject to Ubp2 regulation.	Lysine	24-27	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	71-75
17028178-6	2006	A large fraction of the Lys(63) conjugates in ubp2Delta cells bound to Rsp5, and a proteomics approach was used to identify Rsp5 substrates subject to Ubp2 regulation.	Lysine	24-27	ubiquitin-specific protease UBP2	Saccharomyces cerevisiae S288C	151-155
17028178-8	2006	Both were efficiently Lys(63)-polyubiquitinated by Rsp5 and deubiquitinated by Ubp2.	Lysine	22-25	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	51-55
17028178-8	2006	Both were efficiently Lys(63)-polyubiquitinated by Rsp5 and deubiquitinated by Ubp2.	Lysine	22-25	ubiquitin-specific protease UBP2	Saccharomyces cerevisiae S288C	79-83
17028178-9	2006	Together, these results indicate that Ubp2 modulates Lys(63)-polyubiquitination of Rsp5 substrates in vivo, including ubiquitination of two newly identified Rsp5 substrates.	Lysine	53-56	ubiquitin-specific protease UBP2	Saccharomyces cerevisiae S288C	38-42
17028178-9	2006	Together, these results indicate that Ubp2 modulates Lys(63)-polyubiquitination of Rsp5 substrates in vivo, including ubiquitination of two newly identified Rsp5 substrates.	Lysine	53-56	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	83-87
16767160-1	2006	Reversible acetylation on protein lysine residues has been shown to regulate the function of both nuclear proteins such as histones and p53 and cytoplasmic proteins such as alpha-tubulin.	Lysine	34-40	transformation related protein 53, pseudogene	Mus musculus	136-139
17066076-4	2006	Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1.	Lysine	177-183	protein inhibitor of activated STAT 1	Homo sapiens	54-59
17066076-4	2006	Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1.	Lysine	177-183	protein inhibitor of activated STAT 1	Homo sapiens	61-99
17028574-2	2006	Among them, the myogenic transcription factor MyoD shows an increased transcriptional activity in vitro when acetylated on two lysines (K): lysines 99 and 102.	Lysine	127-134	myogenic differentiation 1	Mus musculus	46-50
17028574-2	2006	Among them, the myogenic transcription factor MyoD shows an increased transcriptional activity in vitro when acetylated on two lysines (K): lysines 99 and 102.	Lysine	140-147	myogenic differentiation 1	Mus musculus	46-50
17028574-4	2006	Using specific antibodies, we show that endogenous MyoD is acetylated on lysines 99 and 102 in myoblasts.	Lysine	73-80	myogenic differentiation 1	Mus musculus	51-55
17028574-5	2006	Moreover, we show the functional importance of acetylation in live animals by using a mutant of MyoD in which lysines 99 and 102 were replaced by arginines (R).	Lysine	110-117	myogenic differentiation 1	Mus musculus	96-100
17056793-2	2006	Distinct lysine residues in histones are targets for covalent binding of biotin, catalyzed by holocarboxylase synthetase (HCS) and biotinidase (BTD).	Lysine	9-15	Holocarboxylase synthetase	Drosophila melanogaster	94-120
17056793-2	2006	Distinct lysine residues in histones are targets for covalent binding of biotin, catalyzed by holocarboxylase synthetase (HCS) and biotinidase (BTD).	Lysine	9-15	Holocarboxylase synthetase	Drosophila melanogaster	122-125
17056793-2	2006	Distinct lysine residues in histones are targets for covalent binding of biotin, catalyzed by holocarboxylase synthetase (HCS) and biotinidase (BTD).	Lysine	9-15	Biotinidase	Drosophila melanogaster	131-142
17056793-2	2006	Distinct lysine residues in histones are targets for covalent binding of biotin, catalyzed by holocarboxylase synthetase (HCS) and biotinidase (BTD).	Lysine	9-15	Biotinidase	Drosophila melanogaster	144-147
16928690-8	2006	MS/MS analysis of the purified proteolytic fragments suggests that lysine 56 of Fpg and lysine 249 of hOgg1 cross-link to the phosphate located 3" to the 8-oxoG residue.	Lysine	67-73	8-oxoguanine DNA glycosylase	Homo sapiens	102-107
16928690-8	2006	MS/MS analysis of the purified proteolytic fragments suggests that lysine 56 of Fpg and lysine 249 of hOgg1 cross-link to the phosphate located 3" to the 8-oxoG residue.	Lysine	88-94	8-oxoguanine DNA glycosylase	Homo sapiens	102-107
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	137-143	purinergic receptor P2X 2	Homo sapiens	46-50
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	137-143	purinergic receptor P2X 2	Homo sapiens	90-96
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	137-143	purinergic receptor P2X 2	Homo sapiens	90-94
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	231-238	purinergic receptor P2X 2	Homo sapiens	46-50
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	231-238	purinergic receptor P2X 2	Homo sapiens	90-96
16840712-4	2006	By coexpression of wild-type P2X3 and mutated P2X2 subunit, we found that the heteromeric P2X2/3 channel functioned normally when either lysine in the P2X2 subunit was mutated to alanine (i.e., [K69A] or [K308A]) but not when both lysines were mutated to alanine (i.e., [K69A, K308A]).	Lysine	231-238	purinergic receptor P2X 2	Homo sapiens	90-94
16840712-6	2006	The rescue of the single lysine mutant P2X2 subunit by wild-type P2X3 (but not the converse) suggests that the heteromeric channel contains one P2X2 and two P2X3 subunits and that the receptor functions essentially normally as long as two subunits are not mutated.	Lysine	25-31	purinergic receptor P2X 2	Homo sapiens	39-43
16840712-6	2006	The rescue of the single lysine mutant P2X2 subunit by wild-type P2X3 (but not the converse) suggests that the heteromeric channel contains one P2X2 and two P2X3 subunits and that the receptor functions essentially normally as long as two subunits are not mutated.	Lysine	25-31	purinergic receptor P2X 2	Homo sapiens	144-148
16840712-7	2006	The failure to rescue function in the P2X2 subunit with both lysines mutated by wild-type P2X3 suggests that these residues from two different subunits interact in agonist binding or channel opening.	Lysine	61-68	purinergic receptor P2X 2	Homo sapiens	38-42
17024155-6	2006	In this capacity menin is a regulator of expression of the cyclin-dependent-kinase inhibitors p18INK4C and p27Kip1; furthermore, menin serves as a co-activator of estrogen receptor mediated transcription, by recruiting methyltransferase activity to lysine 4 of histone 3 at the estrogen responsive TFF1(pS2) gene promoter.	Lysine	249-255	cyclin dependent kinase inhibitor 1B	Homo sapiens	107-114
16849322-0	2006	Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation.	Lysine	0-6	catenin beta 1	Homo sapiens	37-49
16849322-0	2006	Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation.	Lysine	0-3	catenin beta 1	Homo sapiens	37-49
16849322-0	2006	Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation.	Lysine	16-19	catenin beta 1	Homo sapiens	37-49
16920917-3	2006	The CD300b cDNA open reading frame encodes a 201-aa type I protein composed of a single extracellular Ig V-type domain followed by a transmembrane region containing a positively charged residue (lysine) which is a common feature among receptors that associate with activating adaptor proteins.	Lysine	195-201	CD300 molecule like family member b	Homo sapiens	4-10
16862162-1	2006	The Ubc13 E2 ubiquitin-conjugating enzyme is key in the process of "tagging" target proteins with lysine 63-linked polyubiquitin chains, which are essential for the transmission of immune receptor signals culminating in activation of the transcription factor NF-kappaB.	Lysine	98-104	ubiquitin conjugating enzyme E2 N	Homo sapiens	4-9
16924011-8	2006	Analysis of TNNI2 encoding the troponin I isoform expressed in type 2 muscle fibers disclosed a heterozygous three-base in-frame deletion, 2,918-2,920del, skipping the highly conserved lysine at position 176.	Lysine	185-191	troponin I2, fast skeletal type	Homo sapiens	12-17
16893187-3	2006	Given the key biochemical processes in which hUev1a is involved, it is important to determine the molecular basis of the catalytic mechanism for Lys(63)-linked protein ubiquitination.	Lysine	145-148	ubiquitin conjugating enzyme E2 V1	Homo sapiens	45-51
16893187-5	2006	A structural model for the Ub-hUev1a-hUbc13-Ub tetramer was developed to gain chemical insight into the synthesis of Lys(63)-linked Ub chains.	Lysine	117-120	ubiquitin conjugating enzyme E2 V1	Homo sapiens	30-36
16893187-5	2006	A structural model for the Ub-hUev1a-hUbc13-Ub tetramer was developed to gain chemical insight into the synthesis of Lys(63)-linked Ub chains.	Lysine	117-120	ubiquitin conjugating enzyme E2 N	Homo sapiens	37-43
16893187-6	2006	We propose that a network of hydrogen bonds involving hUbc13-Asp(81) and Ub-Glu(64) positions Ub-Lys(63) proximal to the active site.	Lysine	97-100	ubiquitin conjugating enzyme E2 N	Homo sapiens	54-60
16912182-6	2006	More interestingly, the expression level of acetyltransferase cyclic AMP-responsive element binding protein-binding protein (CBP) is also increased in the Etk transgenic prostate as well as in a prostate cancer cell line overexpressing Etk, concomitant with elevated histone 3 acetylation at lysine 18 (H3K18Ac).	Lysine	292-298	BMX non-receptor tyrosine kinase	Homo sapiens	155-158
16912182-6	2006	More interestingly, the expression level of acetyltransferase cyclic AMP-responsive element binding protein-binding protein (CBP) is also increased in the Etk transgenic prostate as well as in a prostate cancer cell line overexpressing Etk, concomitant with elevated histone 3 acetylation at lysine 18 (H3K18Ac).	Lysine	292-298	BMX non-receptor tyrosine kinase	Homo sapiens	236-239
16889659-13	2006	A highly conserved carboxy-terminal lysine was identified, which suggests Vps25 is ubiquitinated.	Lysine	36-42	ESCRT-II subunit protein VPS25	Saccharomyces cerevisiae S288C	74-79
16783012-4	2006	This substitution appears to abolish all DNA damage-tolerance activities normally carried out by the RAD6/RAD18 pathway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-dependent component of this pathway, but has little effect on the growth rate, suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA.	Lysine	372-378	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	101-105
16783012-4	2006	This substitution appears to abolish all DNA damage-tolerance activities normally carried out by the RAD6/RAD18 pathway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-dependent component of this pathway, but has little effect on the growth rate, suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA.	Lysine	372-378	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	178-182
16732293-2	2006	Tri- and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is required for the binding of the repressive protein HP1 and is associated with heterochromatin formation and transcriptional repression in a variety of species.	Lysine	26-32	defensin alpha 1	Homo sapiens	117-120
16729975-3	2006	Mutational analysis reveals that sumoylation of Ets-1 occurs at two lysine residues at amino acid positions 15 and 227, which lie within previously identified synergy control motifs.	Lysine	68-74	ETS proto-oncogene 1, transcription factor	Homo sapiens	48-53
16729975-4	2006	Replacement of sumoylation site lysines with arginine or overexpression of SENP1, a desumoylation enzyme, enhances the transactivation ability of Ets-1.	Lysine	32-39	ETS proto-oncogene 1, transcription factor	Homo sapiens	146-151
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	interleukin 1 alpha	Mus musculus	174-178
16814719-4	2006	Here we show that physiological levels of nucleotides inhibit the CC-initiated apoptosome formation and caspase-9 activation by directly binding to CC on several key lysine residues and thus preventing CC interaction with Apaf-1.	Lysine	166-172	caspase 9	Homo sapiens	104-113
16805913-6	2006	Although accumulating evidence suggests that methylation of histone 3, lysine 36 (H3K36) is associated with actively transcribed genes, we show that the SET domain of Smyd2 mediates H3K36 dimethylation and that Smyd2 represses transcription from an SV40-luciferase reporter.	Lysine	71-77	SET and MYND domain containing 2	Homo sapiens	167-172
16613853-0	2006	Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes.	Lysine	11-17	adiponectin, C1Q and collagen domain containing	Mus musculus	80-91
16787775-0	2006	Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.	Lysine	88-94	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	31-35
16621799-12	2006	Functional studies of adiponectin-null mice revealed that abrogation of lysine hydroxylation/glycosylation markedly decreased the ability of adiponectin to stimulate phosphorylation of AMP-activated protein kinase in liver tissue.	Lysine	72-78	adiponectin, C1Q and collagen domain containing	Mus musculus	22-33
16621799-12	2006	Functional studies of adiponectin-null mice revealed that abrogation of lysine hydroxylation/glycosylation markedly decreased the ability of adiponectin to stimulate phosphorylation of AMP-activated protein kinase in liver tissue.	Lysine	72-78	adiponectin, C1Q and collagen domain containing	Mus musculus	141-152
16515785-7	2006	Furthermore, deletion of a subdomain (KRKHPRRAQ) in the peptide or amino acid substitution of lysine and arginine residues in the subdomain resulted in the loss of Nop25 nucleolar localization.	Lysine	94-100	nucleolar protein 12	Homo sapiens	164-169
16515785-8	2006	These results suggest that the lysine and arginine residue-enriched peptide is the most prominent nucleolar targeting sequence of Nop25 and that the long stretch of basic residues might play an important role in the nucleolar localization of Nop25.	Lysine	31-37	nucleolar protein 12	Homo sapiens	130-135
16515785-8	2006	These results suggest that the lysine and arginine residue-enriched peptide is the most prominent nucleolar targeting sequence of Nop25 and that the long stretch of basic residues might play an important role in the nucleolar localization of Nop25.	Lysine	31-37	nucleolar protein 12	Homo sapiens	242-247
16704420-1	2006	Cleavage of the small amyloidogenic protein beta2-microglobulin after lysine-58 renders it more prone to unfolding and aggregation.	Lysine	70-76	beta-2-microglobulin	Homo sapiens	44-63
16704420-4	2006	We here use such methods to examine beta2-microglobulin cleaved after lysine-58 and the further processed variant (found in vivo) from which lysine-58 is removed.	Lysine	70-76	beta-2-microglobulin	Homo sapiens	36-55
16704420-5	2006	We find that the solution stability of both variants, especially of beta2-microglobulin from which lysine-58 is removed, is much reduced compared to wild-type beta2-microglobulin and is strongly dependent on temperature and protein concentration.	Lysine	99-105	beta-2-microglobulin	Homo sapiens	68-87
16704420-5	2006	We find that the solution stability of both variants, especially of beta2-microglobulin from which lysine-58 is removed, is much reduced compared to wild-type beta2-microglobulin and is strongly dependent on temperature and protein concentration.	Lysine	99-105	beta-2-microglobulin	Homo sapiens	159-178
16552718-4	2006	The Leu-enkephalin peptide-micelle association constant increased from 130 +/- 8 to 1459 +/- 57 and 1744 +/- 64 M(-1), respectively, when an Arg or Lys was added to the C-terminus.	Lysine	148-151	prodynorphin	Homo sapiens	4-18
16732283-4	2006	X-ray structures for wild-type and mutant human Ubc9-RanGAP1 complexes showed partial loss of contacts to the substrate lysine in mutant complexes.	Lysine	120-126	Ran GTPase activating protein 1	Homo sapiens	53-60
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Lysine	66-69	lymphocyte antigen 96	Mus musculus	162-166
16623599-4	2006	In contrast, a high degree of specificity for the basic side chain could be observed because the KIR-DAP12 and FcalphaRI-Fcgamma interactions favored lysine or arginine, respectively.	Lysine	150-156	transmembrane immune signaling adaptor TYROBP	Homo sapiens	101-106
16630895-4	2006	The mode of recognition at each site is virtually identical: three conserved, calcium-coordinating acidic residues from each LDLR module encircle a lysine side chain protruding from the second helix of RAP.	Lysine	148-154	low density lipoprotein receptor	Homo sapiens	125-129
16630895-4	2006	The mode of recognition at each site is virtually identical: three conserved, calcium-coordinating acidic residues from each LDLR module encircle a lysine side chain protruding from the second helix of RAP.	Lysine	148-154	LDL receptor related protein associated protein 1	Homo sapiens	202-205
16601694-5	2006	This lysine-63-linked polyubiquitination requires both UbcH5b/c and Ubc13-conjugating enzymes for initiating mono- and subsequent polyubiquitination of class I, and the clathrin-dependent internalisation is mediated by the epsin endocytic adaptor.	Lysine	5-11	ubiquitin conjugating enzyme E2 D2	Homo sapiens	55-61
16601694-5	2006	This lysine-63-linked polyubiquitination requires both UbcH5b/c and Ubc13-conjugating enzymes for initiating mono- and subsequent polyubiquitination of class I, and the clathrin-dependent internalisation is mediated by the epsin endocytic adaptor.	Lysine	5-11	ubiquitin conjugating enzyme E2 N	Homo sapiens	68-73
16603626-4	2006	So far as we know, the myosin sites that first respond are the two lysine-rich loops that produce an ionic strength-dependent weak-binding complex with actin.	Lysine	67-73	myosin heavy chain 14	Homo sapiens	23-29
16603626-8	2006	On the other hand, that of loop 2 (dependent on drawing close two myosin lysines and two actin aspartates) is probably responsible for opening switch I and uncovering the gamma-phosphate moiety of bound ATP.	Lysine	73-80	myosin heavy chain 14	Homo sapiens	66-72
16594669-2	2006	Here we describe the use of the transglutaminase enzyme from guinea pig liver (gpTGase), whose natural function is to cross-link glutamine and lysine side chains, to covalently conjugate various small-molecule probes to recombinant proteins fused to a 6- or 7-amino acid transglutaminase recognition sequence, called a Q-tag.	Lysine	143-149	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	32-48
16594669-2	2006	Here we describe the use of the transglutaminase enzyme from guinea pig liver (gpTGase), whose natural function is to cross-link glutamine and lysine side chains, to covalently conjugate various small-molecule probes to recombinant proteins fused to a 6- or 7-amino acid transglutaminase recognition sequence, called a Q-tag.	Lysine	143-149	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	271-287
16446282-4	2006	We hypothesized that acute striatal injury may be induced in GCDH-deficient (Gcdh-/-) mice by elevated dietary protein and lysine.	Lysine	123-129	glutaryl-Coenzyme A dehydrogenase	Mus musculus	77-81
16446282-6	2006	High lysine alone resulted in vasogenic oedema and blood-brain barrier breakdown within the striatum, associated with serum and tissue GA accumulation, neuronal loss, haemorrhage, paralysis, seizures and death in 75% of 4-week-old Gcdh-/- mice after 3-12 days.	Lysine	5-11	glutaryl-Coenzyme A dehydrogenase	Mus musculus	231-235
16446282-7	2006	In contrast, most 8-week-old Gcdh-/- mice survived on high lysine, but developed white matter lesions, reactive astrocytes and neuronal loss after 6 weeks.	Lysine	59-65	glutaryl-Coenzyme A dehydrogenase	Mus musculus	29-33
16446282-8	2006	Thus, the Gcdh-/- mouse exposed to high protein or lysine may be a useful model of human GA-1 including developmentally dependent striatal vulnerability.	Lysine	51-57	glutaryl-Coenzyme A dehydrogenase	Mus musculus	10-14
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	80-83	tumor protein p53 binding protein 1	Homo sapiens	66-72
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	80-83	tumor protein p53 binding protein 1	Homo sapiens	191-197
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53 binding protein 1	Homo sapiens	66-72
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53 binding protein 1	Homo sapiens	191-197
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53 binding protein 1	Homo sapiens	66-72
16314399-6	2006	Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).	Lysine	206-209	tumor protein p53 binding protein 1	Homo sapiens	191-197
16396988-8	2006	The revised sequence encodes lysine at position 21, which is consistent with all reported GHRH sequences from other species but different from the originally published chicken sequence.	Lysine	29-35	growth hormone releasing hormone	Gallus gallus	90-94
16547522-0	2006	Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].	Lysine	11-14	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	47-51
16547522-6	2006	The recruitment of IKK to occupied cytokine receptors, and its subsequent activation, are dependent on the attachment of Lys 63-linked polyubiquitin chains to signalling intermediates such as receptor-interacting protein (RIP).	Lysine	121-124	receptor interacting serine/threonine kinase 1	Homo sapiens	192-220
16547522-6	2006	The recruitment of IKK to occupied cytokine receptors, and its subsequent activation, are dependent on the attachment of Lys 63-linked polyubiquitin chains to signalling intermediates such as receptor-interacting protein (RIP).	Lysine	121-124	receptor interacting serine/threonine kinase 1	Homo sapiens	222-225
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	transition protein 2	Homo sapiens	124-127
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	200-204
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	206-210
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	transition protein 2	Homo sapiens	223-226
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	transition protein 2	Homo sapiens	124-127
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	200-204
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	206-210
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	transition protein 2	Homo sapiens	223-226
25786853-7	2015	We found that reducing the levels of histone H4 lysine 16 acetylation or H3 lysine 79 methylation partially suppresses these sensitivities and reduces spontaneous and genotoxin-induced activation of the DNA damage-response kinase Rad53 in hst3  hst4  cells.	Lysine	48-54	NAD-dependent histone deacetylase HST3	Saccharomyces cerevisiae S288C	239-243
25500144-6	2015	RESULTS: Ectopic CCRK expression in immortalized human liver cells increased EZH2 and histone H3 lysine 27 trimethylation (H3K27me3) to stimulate proliferation and tumor formation.	Lysine	97-103	cyclin dependent kinase 20	Homo sapiens	17-21
25590533-0	2015	Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.	Lysine	71-77	tumor protein p53 binding protein 1	Homo sapiens	95-100
25590533-3	2015	We specifically targeted the DNA damage response protein, 53BP1, which uses its tandem tudor domain to recognize histone H4 dimethylated on lysine 20 (H4K20me2), a modification related to double-strand DNA breaks.	Lysine	140-146	tumor protein p53 binding protein 1	Homo sapiens	58-63
25607372-10	2015	This targeting to transcribed sequences requires SETD2-mediated methylation of lysine 36 on histone H3 and a functional PWWP domain of DNMT3B.	Lysine	79-85	DNA methyltransferase 3 beta	Homo sapiens	135-141
25614623-5	2015	Asp(25) and Lys(30) of medin align with residues Asp(23) and Lys(28) of Abeta, which are known to form a stabilizing salt bridge in some fibril morphologies.	Lysine	12-15	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	23-28
25614623-5	2015	Asp(25) and Lys(30) of medin align with residues Asp(23) and Lys(28) of Abeta, which are known to form a stabilizing salt bridge in some fibril morphologies.	Lysine	61-64	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	23-28
25614623-7	2015	Wild-type medin, by contrast, aggregates into beta-sheet-rich amyloid-like fibrils within 50 h. A structural analysis of wild-type fibrils by solid-state NMR suggests a molecular repeat unit comprising at least two extended beta-strands, separated by a turn stabilized by a Asp(25)-Lys(30) salt bridge.	Lysine	282-285	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	10-15
25727006-2	2015	We have discovered that CUL4A-RBX1-COPS8 E3 ligase activity is required for CENP-A ubiquitylation on lysine 124 (K124) and CENP-A centromere localization.	Lysine	101-107	COP9 signalosome subunit 8	Homo sapiens	35-40
25742135-6	2015	The BmANTI2 protein has an N-terminal extension in which the positions of lysine residues in the amino acid sequence are distributed as in human ANT4.	Lysine	74-80	solute carrier family 25 member 31	Homo sapiens	145-149
25574816-7	2015	RESULTS: Histone H1.2, which lacks histidine, was phosphorylated by phosphoramidate on several lysine residues, as shown by MS. PHPT1 was shown to dephosphorylate phosphohistone H1 at a rate similar to that previously described for the dephosphorylation of phosphohistidine-containing peptides.	Lysine	95-101	H1.2 linker histone, cluster member	Homo sapiens	17-21
25548288-3	2015	Little is known about how Bre1 directs Rad6 toward transferring only a single ubiquitin to a specific lysine residue.	Lysine	102-108	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	39-43
25544292-6	2015	We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at the Stra6 RARE; 2) RA increases co-activator p300 (KAT3B) binding and histone H3 Lys-27 acetylation at both promoters; 3) RA decreases Suz12 levels and histone H3 Lys-27 trimethylation epigenetic marks at both promoters; and 4) these epigenetic changes are diminished in the absence of RARgamma.	Lysine	167-170	retinoic acid response element 2	Mus musculus	96-103
25544292-6	2015	We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at the Stra6 RARE; 2) RA increases co-activator p300 (KAT3B) binding and histone H3 Lys-27 acetylation at both promoters; 3) RA decreases Suz12 levels and histone H3 Lys-27 trimethylation epigenetic marks at both promoters; and 4) these epigenetic changes are diminished in the absence of RARgamma.	Lysine	249-252	stimulated by retinoic acid gene 6	Mus musculus	90-95
25544292-6	2015	We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at the Stra6 RARE; 2) RA increases co-activator p300 (KAT3B) binding and histone H3 Lys-27 acetylation at both promoters; 3) RA decreases Suz12 levels and histone H3 Lys-27 trimethylation epigenetic marks at both promoters; and 4) these epigenetic changes are diminished in the absence of RARgamma.	Lysine	249-252	retinoic acid response element 2	Mus musculus	96-103
25537508-6	2015	The RUNX1 promoter is bound by enhancer of zeste homolog 2 (EZH2) and is negatively regulated by histone H3 lysine 27 (K27) trimethylation.	Lysine	108-114	RUNX family transcription factor 1	Homo sapiens	4-9
25561279-6	2015	In contrast, L-lysine (Lys)-coated Fe3O4 NPs showed strong binding with the monomeric A-syn, inhibiting the early events of aggregation.	Lysine	13-21	synuclein alpha	Homo sapiens	86-91
25561279-6	2015	In contrast, L-lysine (Lys)-coated Fe3O4 NPs showed strong binding with the monomeric A-syn, inhibiting the early events of aggregation.	Lysine	23-26	synuclein alpha	Homo sapiens	86-91
25483313-9	2015	A mitochondrial substrate of Sirt3, succinate dehydrogenase (SDH), is regulated by Sirt3 via lysine residue acetylation status of SDH.	Lysine	93-99	sirtuin 3	Rattus norvegicus	29-34
25483313-9	2015	A mitochondrial substrate of Sirt3, succinate dehydrogenase (SDH), is regulated by Sirt3 via lysine residue acetylation status of SDH.	Lysine	93-99	sirtuin 3	Rattus norvegicus	83-88
25565142-2	2015	We show that menin activates the long noncoding RNA maternally expressed gene 3 (Meg3) by histone-H3 lysine-4 trimethylation and CpG hypomethylation at the Meg3 promoter CRE site, to allow binding of the transcription factor cAMP response element-binding protein.	Lysine	101-107	maternally expressed 3	Mus musculus	52-79
25565142-2	2015	We show that menin activates the long noncoding RNA maternally expressed gene 3 (Meg3) by histone-H3 lysine-4 trimethylation and CpG hypomethylation at the Meg3 promoter CRE site, to allow binding of the transcription factor cAMP response element-binding protein.	Lysine	101-107	maternally expressed 3	Mus musculus	81-85
25492870-0	2015	Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.	Lysine	41-47	Asi2p	Saccharomyces cerevisiae S288C	53-57
25492870-3	2015	Here we report that a fully functional lysine-less mutant of an inner nuclear membrane protein in yeast, Asi2, is polyubiquitylated and targeted for proteasomal degradation.	Lysine	39-45	Asi2p	Saccharomyces cerevisiae S288C	105-109
25492870-4	2015	Efficient degradation of lysine-free Asi2 requires E3-ligase Doa10 and E2 enzymes Ubc6 and Ubc7, components of the endoplasmic reticulum-associated degradation pathway.	Lysine	25-31	Asi2p	Saccharomyces cerevisiae S288C	37-41
25489884-3	2015	Using this methodology, we have studied the temperature dependence of the internal motions of the lysine side-chain NH3(+) groups that form ion pairs with DNA phosphate groups in the HoxD9 homeodomain-DNA complex.	Lysine	98-104	homeobox D9	Homo sapiens	183-188
25429968-5	2015	This PI(4,5)P2 site uses Arg-47 and Lys-13 as phosphate ligands, explaining why PTEN R47G and K13E can no longer be activated by that phosphoinositide.	Lysine	36-39	phosphatase and tensin homolog	Homo sapiens	80-84
25489787-3	2015	This study is the first to report the development of a real-time molecular imaging biosensor (a fusion protein, [FLuc2]-[Suv39h1]-[(G4S)3]-[H3-K9]-[cODC]) that can detect and monitor the methylation status of a specific histone lysine methylation mark (H3-K9) in live animals.	Lysine	228-234	suppressor of variegation 3-9 1	Mus musculus	121-128
25572421-3	2015	We found that the trimethylation of lysine 36 on histone H3 (H3K36me3), a modification that is associated with gene activation, is enhanced in Bam-expressing cells.	Lysine	36-42	bag of marbles	Drosophila melanogaster	143-146
25588111-1	2015	Heterochromatin protein 1alpha (HP1alpha) encoded from the CBX5-gene is an evolutionary conserved protein that binds histone H3 di- or tri-methylated at position lysine 9 (H3K9me2/3), a hallmark for heterochromatin, and has an essential role in forming higher order chromatin structures.	Lysine	162-168	chromobox 5	Homo sapiens	0-30
25588111-1	2015	Heterochromatin protein 1alpha (HP1alpha) encoded from the CBX5-gene is an evolutionary conserved protein that binds histone H3 di- or tri-methylated at position lysine 9 (H3K9me2/3), a hallmark for heterochromatin, and has an essential role in forming higher order chromatin structures.	Lysine	162-168	chromobox 5	Homo sapiens	32-40
25588111-1	2015	Heterochromatin protein 1alpha (HP1alpha) encoded from the CBX5-gene is an evolutionary conserved protein that binds histone H3 di- or tri-methylated at position lysine 9 (H3K9me2/3), a hallmark for heterochromatin, and has an essential role in forming higher order chromatin structures.	Lysine	162-168	chromobox 5	Homo sapiens	59-63
26315885-1	2015	Ubiquitin is a small modifier protein that conjugates on lysine (Lys) residues of substrates, and it can be targeted by another ubiquitin molecule to form chains through conjugation on the intrinsic Lys residues and methionine (Met) 1 residue.	Lysine	57-63	granzyme M	Homo sapiens	216-234
26315885-1	2015	Ubiquitin is a small modifier protein that conjugates on lysine (Lys) residues of substrates, and it can be targeted by another ubiquitin molecule to form chains through conjugation on the intrinsic Lys residues and methionine (Met) 1 residue.	Lysine	65-68	granzyme M	Homo sapiens	216-234
26037225-4	2015	Here we demonstrate that C-terminal lysines may interfere with this process, leading to suboptimal C1q binding and CDC of cells opsonized with C-terminal lysine-containing IgG.	Lysine	36-43	complement C1q A chain	Homo sapiens	99-102
26037225-4	2015	Here we demonstrate that C-terminal lysines may interfere with this process, leading to suboptimal C1q binding and CDC of cells opsonized with C-terminal lysine-containing IgG.	Lysine	36-42	complement C1q A chain	Homo sapiens	99-102
25527207-9	2014	ChIP analysis revealed that PRC2-mediated trimethylation of Lys 27 on histone H3 (H3K27me3) was increased in the KRT13 promoter in the HSC3 and SAS cells.	Lysine	60-63	keratin 13	Homo sapiens	113-118
25527207-9	2014	ChIP analysis revealed that PRC2-mediated trimethylation of Lys 27 on histone H3 (H3K27me3) was increased in the KRT13 promoter in the HSC3 and SAS cells.	Lysine	60-63	tetraspanin 31	Homo sapiens	144-147
25318671-6	2014	Nevertheless, only Sox10 histone H3 lysine 36 dimethylation requires NSD3, revealing unexpected complexity in NSD3-dependent neural crest gene regulation.	Lysine	36-42	SRY-box transcription factor 10	Homo sapiens	19-24
25382779-0	2014	Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.	Lysine	0-6	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	36-42
25301943-1	2014	Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimulates interaction between nucleosomes and histone deacetylase complexes to block cryptic transcription in budding yeast.	Lysine	44-51	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	64-68
25305019-8	2014	Finally, we demonstrated that USP16 could deubiquitinate both H2A Lys-119 and H2A Lys-15 ubiquitination in vitro.	Lysine	66-69	ubiquitin specific peptidase 16	Homo sapiens	30-35
25305019-8	2014	Finally, we demonstrated that USP16 could deubiquitinate both H2A Lys-119 and H2A Lys-15 ubiquitination in vitro.	Lysine	82-85	ubiquitin specific peptidase 16	Homo sapiens	30-35
25305019-9	2014	Therefore, this study identifies USP16 as a critical regulator of DNA damage response and H2A Lys-15 ubiquitination as a potential target of USP16.	Lysine	94-97	ubiquitin specific peptidase 16	Homo sapiens	141-146
25419572-4	2014	However, little is known about the reactivity and location of the glutamine and lysine residues involved in the TG2-mediated modification of OPN.	Lysine	80-86	secreted phosphoprotein 1	Homo sapiens	141-144
25419572-7	2014	The distribution of reactive Gln and Lys residues in OPN proved to be important, as the full-length protein but not the physiologically highly active integrin-binding N-terminal part of OPN were able to polymerize in a TG2-mediated reaction.	Lysine	37-40	secreted phosphoprotein 1	Homo sapiens	53-56
25216241-5	2014	The transcriptional repression of HMGCR was associated with CpG island hypermethylation and higher repressive histone mark H3K27me3 (histone H3 lysine 27 trimethylation) on the promoter, whereas increased HMGCR protein content was associated with significantly decreased expression of miR-497.	Lysine	144-150	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	34-39
24814981-1	2014	Acetylation of alpha-tubulin on lysine 40 is one of the major posttranslational modifications of microtubules.	Lysine	32-38	tubulin alpha 1b	Homo sapiens	15-28
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	88-94	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	50-55
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	88-94	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	50-55
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	88-94	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	50-55
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	88-94	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	50-55
25196737-3	2014	Here, we designed and synthesized analogues of TAK-242, a small molecule inhibitor of Toll-like receptor 4, that primarily reacted with a single lysine residue of HSA.	Lysine	145-151	toll like receptor 4	Homo sapiens	86-106
25263594-0	2014	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	Lysine	45-51	zinc finger MYND-type containing 11	Homo sapiens	0-4
25263594-0	2014	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	Lysine	45-51	zinc finger MYND-type containing 11	Homo sapiens	5-12
25263594-2	2014	Here, we show that BS69 selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains.	Lysine	68-74	zinc finger MYND-type containing 11	Homo sapiens	19-23
25341040-5	2014	In this study, we found that EZH2 suppresses miR-31 expression by trimethylation of lysine 27 on histone 3 on the miR-31 promoter.	Lysine	84-90	microRNA 31	Homo sapiens	45-51
25341040-5	2014	In this study, we found that EZH2 suppresses miR-31 expression by trimethylation of lysine 27 on histone 3 on the miR-31 promoter.	Lysine	84-90	microRNA 31	Homo sapiens	114-120
24905915-3	2014	We aimed at investigating the role, of the positive charged lysine residues at the KTKEGV repeat motif, in mediating alpha-Syn associations with membrane phospholipids and in alpha-Syn oligomerization and aggregation.	Lysine	60-66	synuclein alpha	Homo sapiens	117-126
24905915-8	2014	Together, our results suggest a critical role for lysine residues at the N-terminal repeat domain in the pathophysiology of alpha-Syn.	Lysine	50-56	synuclein alpha	Homo sapiens	124-133
25273096-4	2014	In vitro reporter alleles demonstrated a reduction in histone 4 acetylation and histone 3 lysine 4 trimethylation (H3K4me3) activity in mouse embryonic fibroblasts from Kmt2d(+/betaGeo) mice.	Lysine	90-96	lysine (K)-specific methyltransferase 2D	Mus musculus	169-174
25086053-10	2014	14-3-3gamma Ser(58) phosphorylation is required for STAR interactions under control conditions, and 14-3-3gamma Lys(49) acetylation is important for the cAMP-dependent induction of these interactions.	Lysine	112-115	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	100-111
25104354-2	2014	HP1alpha detects histone dimethylation and trimethylation of Lys-9 via its chromodomain.	Lysine	61-64	chromobox 5	Homo sapiens	0-8
25015965-0	2014	Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.	Lysine	69-75	histone deacetylase 1	Bos taurus	0-21
25015965-9	2014	Thus these data indicate that upregulated HDAC1 decreases NOS3 activity, most likely through direct lysine deacetylation of NOS3.	Lysine	100-106	histone deacetylase 1	Bos taurus	42-47
25086354-3	2014	Mass spectrometric analysis of EF2 tryptic peptides localised this loss of methylation to lysine 509, in peptide LVEGLKR.	Lysine	90-96	eukaryotic translation elongation factor 2	Homo sapiens	31-34
25086354-4	2014	In vitro methylation, using recombinant methyltransferases and purified EF2, validated YJR129Cp as responsible for methylation of lysine 509 and Efm2p as responsible for methylation at lysine 613.	Lysine	130-136	eukaryotic translation elongation factor 2	Homo sapiens	72-75
25086354-4	2014	In vitro methylation, using recombinant methyltransferases and purified EF2, validated YJR129Cp as responsible for methylation of lysine 509 and Efm2p as responsible for methylation at lysine 613.	Lysine	185-191	eukaryotic translation elongation factor 2	Homo sapiens	72-75
24958724-7	2014	We also demonstrate that mutation of Lys-443 and Tyr-474 in RIP2 disrupted the interaction with NOD1.	Lysine	37-40	nucleotide binding oligomerization domain containing 1	Homo sapiens	96-100
24980959-7	2014	RNF2 mediates ubiquitination of AMBRA1 at lysine 45.	Lysine	42-48	autophagy and beclin 1 regulator 1	Homo sapiens	32-38
24973453-5	2014	Among multiple histone acetylations, histone H3 lysine 27 (H3K27) acetylation was most significantly decreased in TIR cells in an HDAC8-dependent manner, and the association of H3K27 acetylation with the genomic regions of BNIP3 and metastatic lymph node 64, where HDAC8 was recruited to, was diminished in TIR cells.	Lysine	48-54	histone deacetylase 8	Mus musculus	130-135
24973453-5	2014	Among multiple histone acetylations, histone H3 lysine 27 (H3K27) acetylation was most significantly decreased in TIR cells in an HDAC8-dependent manner, and the association of H3K27 acetylation with the genomic regions of BNIP3 and metastatic lymph node 64, where HDAC8 was recruited to, was diminished in TIR cells.	Lysine	48-54	histone deacetylase 8	Mus musculus	265-270
24838002-4	2014	Here we report that histone lysine methyltransferase SDG8, implicated in histone 3 lysine 36 di- and trimethylation (H3K36me2 and me3), is involved in BR-regulated gene expression.	Lysine	28-34	histone-lysine N-methyltransferase	Arabidopsis thaliana	53-57
24907272-5	2014	Results from combined mutagenesis and computational modeling studies suggest that RNF4 utilizes concerted bimodular recognition, namely SIM for Lys-676 SUMOylation and ARM for Ser(P)-824 of simultaneously phosphorylated and SUMOylated KAP1 (Ser(P)-824-SUMO-KAP1).	Lysine	144-147	ring finger protein 4	Homo sapiens	82-86
25068395-3	2014	Here, presteady-state and steady-state kinetics of the PSA-catalyzed hydrolysis of the fluorogenic substrate Mu-His-Ser-Ser-Lys-Leu-Gln-AMC (spanning from pH 6.5 to pH 9.0, at 37.0 C) are reported.	Lysine	124-127	kallikrein related peptidase 3	Homo sapiens	55-58
24806961-1	2014	In human cells, appropriate monomethylation of histone H4 lysine 20 by PrSet7 (also known as SET8 and SETD7) is important for the correct transcription of specific genes and timely progression through the cell cycle.	Lysine	58-64	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	102-107
24914048-1	2014	The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice factor U2 auxiliary factor 65 kDa subunit (U2AF65) and to act as a modulator of alternative splicing.	Lysine	86-92	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	50-55
24914048-1	2014	The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice factor U2 auxiliary factor 65 kDa subunit (U2AF65) and to act as a modulator of alternative splicing.	Lysine	86-92	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	133-167
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	94-100	proliferating cell nuclear antigen	Homo sapiens	86-90
24939902-4	2014	Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of chromatin-bound PCNA and its degradation during NER.	Lysine	102-105	proliferating cell nuclear antigen	Homo sapiens	86-90
24884163-6	2014	Of the acetylated proteins, ANT1, which catalyzes ADP-ATP exchange across the inner mitochondrial membrane, was acetylated at lysines 10, 23, and 92.	Lysine	126-133	solute carrier family 25 member 4	Homo sapiens	28-32
24884163-8	2014	Molecular dynamics modeling and ensemble docking simulations predicted the ADP binding site of ANT1 to be a pocket of positively charged residues, including lysine 23.	Lysine	157-163	solute carrier family 25 member 4	Homo sapiens	95-99
24884163-9	2014	Calculated ADP-ANT1 binding affinities were physiologically relevant and predicted substantial reductions in affinity upon acetylation of lysine 23.	Lysine	138-144	solute carrier family 25 member 4	Homo sapiens	15-19
24884163-10	2014	Insertion of these derived binding affinities as parameters into a complete mathematical description of ANT1 kinetics predicted marked reductions in adenine nucleotide flux resulting from acetylation of lysine 23.	Lysine	203-209	solute carrier family 25 member 4	Homo sapiens	104-108
24847881-0	2014	SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.	Lysine	12-18	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	34-40
24847881-7	2014	In cancer cell lines, SMYD3-mediated methylation of MAP3K2 at lysine 260 potentiates activation of the Ras/Raf/MEK/ERK signalling module and SMYD3 depletion synergizes with a MEK inhibitor to block Ras-driven tumorigenesis.	Lysine	62-68	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	52-58
24918754-8	2014	Antibody 2, attaching to reactive lysine residue in the CVD, showed a marked inhibitory effect on in vitro actin-myosin sliding without changing actin-activated myosin head (S1) ATPase activity, while it showed no appreciable effect on muscle contraction.	Lysine	34-40	myosin heavy chain 14	Homo sapiens	113-119
24798798-4	2014	In the first proteolysis step, two fragments of 21 kDa (Glu86-Lys282) and 45 kDa (Ser283-Arg689) were generated because two lysine residues, Lys85 and Lys282, in the structure of iron-saturated bovine lactoferrin were fully exposed.	Lysine	124-130	lactotransferrin	Bos taurus	201-212
24662292-7	2014	The Pex10p Pex12p complex catalyzes monoubiquitination of Pex5p at one of multiple lysine residues in vitro, following the dissociation of Pex5p from Pex14p and the PTS1 cargo.	Lysine	83-89	peroxisomal biogenesis factor 12	Homo sapiens	11-17
24886859-3	2014	In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.	Lysine	55-61	prostaglandin E synthase	Mus musculus	123-130
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	111-114	exonuclease 1	Homo sapiens	45-49
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	115-118	exonuclease 1	Homo sapiens	45-49
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	115-118	exonuclease 1	Homo sapiens	45-49
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	115-118	exonuclease 1	Homo sapiens	45-49
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	115-118	exonuclease 1	Homo sapiens	45-49
24810280-7	2014	Subgroup analysis based on smoking suggested Exo1 K589E polymorphism conferred significant risk among smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 2.16, 95%CI:1.77-2.63, P&lt;0.01), but not in non-smokers (Lys/Lys+Glu/Lys vs Glu/Glu: OR = 0.89, 95%CI:0.64-1.24, P = 0.50).	Lysine	115-118	exonuclease 1	Homo sapiens	45-49
24810280-8	2014	In conclusion, Exo1 K589E Lys allele may be used as a novel biomarker for cancer susceptibility, particularly in smokers.	Lysine	26-29	exonuclease 1	Homo sapiens	15-19
24843002-2	2014	In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand breaks (DSBs).	Lysine	76-82	ATM serine/threonine kinase	Homo sapiens	114-117
24613676-7	2014	On the other hand, glyoxal modifies Lys-133 and Lys-145 to carboxymethyllysine and Arg-31 to hydroimidazolone adducts in myoglobin.	Lysine	36-39	myoglobin	Homo sapiens	121-130
24613676-7	2014	On the other hand, glyoxal modifies Lys-133 and Lys-145 to carboxymethyllysine and Arg-31 to hydroimidazolone adducts in myoglobin.	Lysine	48-51	myoglobin	Homo sapiens	121-130
24435446-1	2014	The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2.	Lysine	100-107	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	185-190
24678731-5	2014	NFIB controlled the expression of mammary-specific and STAT5-regulated genes and chromatin immunoprecipitation-sequencing established STAT5 and NFIB binding at composite regulatory elements containing histone H3 lysine dimethylation enhancer marks and progesterone receptor binding.	Lysine	212-218	signal transducer and activator of transcription 5A	Mus musculus	55-60
24678731-5	2014	NFIB controlled the expression of mammary-specific and STAT5-regulated genes and chromatin immunoprecipitation-sequencing established STAT5 and NFIB binding at composite regulatory elements containing histone H3 lysine dimethylation enhancer marks and progesterone receptor binding.	Lysine	212-218	signal transducer and activator of transcription 5A	Mus musculus	134-139
24769646-5	2014	The level of dimethyl histone H3 lysine 4 (H3K4me2) in the RARalpha gene-promoter region, PU.1 upstream regulatory region (URE) and RUNX1+24/+25 intronic enhancer was higher in MLL-AF9-positive cells than in MLL-AF4-positive cells, and inhibiting lysine-specific demethylase 1, which acts as a histone demethylase inhibitor, reactivated ATRA sensitivity in MLL-AF4-positive cells.	Lysine	33-39	retinoic acid receptor alpha	Homo sapiens	59-67
24797807-8	2014	Tudor is a large protein, which contains multiple Tudor domains--small modules that interact with methylated arginines or lysines of target proteins.	Lysine	122-129	tudor	Drosophila melanogaster	0-5
24797807-8	2014	Tudor is a large protein, which contains multiple Tudor domains--small modules that interact with methylated arginines or lysines of target proteins.	Lysine	122-129	tudor	Drosophila melanogaster	50-55
24616100-7	2014	Biochemical analyses revealed that IRS1/2 decreased Lys-63-linked ubiquitination of Dvl2 and stabilized Dvl2 protein via suppressing its autophagy-mediated degradation.	Lysine	52-55	insulin receptor substrate 1	Homo sapiens	35-41
24616101-9	2014	Strikingly, substitution of Glu(580) in NCX3-B with its NCX3-AC equivalent Lys(580) recapitulated the functional properties of NCX3-AC regarding Ca(2+) sensitivity, Lys(580) presumably acting through a structure stabilization of the Ca(2+) binding site.	Lysine	75-78	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	40-44
24616101-9	2014	Strikingly, substitution of Glu(580) in NCX3-B with its NCX3-AC equivalent Lys(580) recapitulated the functional properties of NCX3-AC regarding Ca(2+) sensitivity, Lys(580) presumably acting through a structure stabilization of the Ca(2+) binding site.	Lysine	75-78	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	56-60
24616101-9	2014	Strikingly, substitution of Glu(580) in NCX3-B with its NCX3-AC equivalent Lys(580) recapitulated the functional properties of NCX3-AC regarding Ca(2+) sensitivity, Lys(580) presumably acting through a structure stabilization of the Ca(2+) binding site.	Lysine	75-78	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	56-60
24616101-9	2014	Strikingly, substitution of Glu(580) in NCX3-B with its NCX3-AC equivalent Lys(580) recapitulated the functional properties of NCX3-AC regarding Ca(2+) sensitivity, Lys(580) presumably acting through a structure stabilization of the Ca(2+) binding site.	Lysine	165-168	solute carrier family 8 (sodium/calcium exchanger), member 3	Mus musculus	40-44
24567327-2	2014	In this work we investigate this relationship by examining alpha-synuclein in the presence of a small molecular tweezer, CLR01, which binds selectively to Lys side chains.	Lysine	155-158	synuclein alpha	Homo sapiens	59-74
24567327-4	2014	Top-down mass-spectrometric analysis shows that the main binding of CLR01 to alpha-synuclein occurs at the N-terminal Lys-10/Lys-12.	Lysine	118-121	synuclein alpha	Homo sapiens	77-92
24567327-4	2014	Top-down mass-spectrometric analysis shows that the main binding of CLR01 to alpha-synuclein occurs at the N-terminal Lys-10/Lys-12.	Lysine	125-128	synuclein alpha	Homo sapiens	77-92
24625057-2	2014	CBX7 uses its chromodomain to bind histone 3, lysine 27 trimethylated (H3K27me3), and this recognition event is implicated in silencing multiple tumor suppressors.	Lysine	46-52	chromobox 7	Homo sapiens	0-4
24722283-7	2014	ChIP assays further showed that the modifications of acetylated histone 4 (H4Ac) and dimethylation at the lysine 9 of histone 3 (H3K9me2) around the rDNA promoter were altered in dao-5 mutants compared with the N2 wild type.	Lysine	106-112	Nucleolar protein dao-5	Caenorhabditis elegans	179-184
23933118-8	2014	Thus, menin by forming a subunit of the mixed lineage leukemia (MLL) complexes that trimethylate histone H3 at lysine 4 (H3K4), facilitates activation of transcriptional activity in target genes such as cyclin-dependent kinase (CDK) inhibitors; and by interacting with the suppressor of variegation 3-9 homolog family protein (SUV39H1) to mediate H3K methylation, thereby silencing transcriptional activity of target genes.	Lysine	111-117	lysine methyltransferase 2A	Homo sapiens	64-67
24140279-3	2014	Recently, it was found that Kin17 is methylated on lysine 135 by the newly discovered methyltransferase METTL22.	Lysine	51-57	methyltransferase 22, Kin17 lysine	Homo sapiens	104-111
24140279-7	2014	Interestingly, overexpression of METTL22 in HEK 293 cells displaces Kin17 from the chromatin to the cytoplasmic fraction, suggesting a role for methylation of lysine 135, a residue that lies within a winged helix domain of Kin17, in regulating association with chromatin.	Lysine	159-165	methyltransferase 22, Kin17 lysine	Homo sapiens	33-40
24474444-1	2014	This study was conducted to determine the optimum ratio of lysine and methionine (Lys:Met) to enhance milk protein concentration in vitro, focusing on the regulation of genes related to the JAK2-STAT5 and the mammalian target of rapamycin (mTOR) signaling pathways.	Lysine	82-85	signal transducer and activator of transcription 5A	Homo sapiens	195-200
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	casein beta	Homo sapiens	47-51
24474444-4	2014	Furthermore, the expression of CSN1S1, CSN1S2, CSN2, CSN3, LALBA, JAK2, STAT5, and MTOR was upregulated with both Lys and Met compared with the control.	Lysine	114-117	signal transducer and activator of transcription 5A	Homo sapiens	72-77
24488492-7	2014	These cytokines suppressed Merm1 protein expression by driving ubiquitination of two conserved lysine residues.	Lysine	95-101	BUD23 rRNA methyltransferase and ribosome maturation factor	Homo sapiens	27-32
24526689-2	2014	Mono-ubiquitination of H2B in the histone tail (at Lys-123 in yeast or Lys-120 in humans) is a conserved modification that has been implicated in the regulation of transcription, replication, and DNA repair processes.	Lysine	51-54	H2B clustered histone 21	Homo sapiens	23-26
24526689-2	2014	Mono-ubiquitination of H2B in the histone tail (at Lys-123 in yeast or Lys-120 in humans) is a conserved modification that has been implicated in the regulation of transcription, replication, and DNA repair processes.	Lysine	71-74	H2B clustered histone 21	Homo sapiens	23-26
24492612-2	2014	Lysine 142 of DNMT1 is methylated by the SET domain containing lysine methyltransferase 7 (SET7), leading to its degradation by proteasome.	Lysine	0-6	KMT5A pseudogene 1	Homo sapiens	91-95
24492612-4	2014	Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner.	Lysine	70-76	PHD finger protein 20 like 1	Homo sapiens	38-45
24425877-10	2014	There were only two major ubiquitination sites in Ret51, Lys(1060) and Lys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitination and degradation of Ret51.	Lysine	57-60	ret proto-oncogene	Homo sapiens	50-55
24425877-10	2014	There were only two major ubiquitination sites in Ret51, Lys(1060) and Lys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitination and degradation of Ret51.	Lysine	57-60	ret proto-oncogene	Homo sapiens	197-202
24425877-10	2014	There were only two major ubiquitination sites in Ret51, Lys(1060) and Lys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitination and degradation of Ret51.	Lysine	71-74	ret proto-oncogene	Homo sapiens	197-202
24425877-10	2014	There were only two major ubiquitination sites in Ret51, Lys(1060) and Lys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitination and degradation of Ret51.	Lysine	117-124	ret proto-oncogene	Homo sapiens	50-55
24425877-10	2014	There were only two major ubiquitination sites in Ret51, Lys(1060) and Lys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitination and degradation of Ret51.	Lysine	117-124	ret proto-oncogene	Homo sapiens	197-202
24459145-3	2014	In contrast, H4 lysine 20 trimethylation (H4K20me3), mediated by SUV420H2, enforces Pol II pausing by inhibiting MSL recruitment.	Lysine	16-22	lysine methyltransferase 5C	Homo sapiens	65-73
24726141-4	2014	We confirmed lysine 528 to be a target of SMYD2-dependent PARP1 methylation by LC-MS/MS and Edman Degradation analyses.	Lysine	13-19	SET and MYND domain containing 2	Homo sapiens	42-47
24516652-3	2014	Previous studies employing oligopeptides and mononucleosomes suggested that acetylation of the H4 tail at lysine 16 (H4K16) within the basic patch may inhibit the activity of ISWI.	Lysine	106-112	Imitation SWI	Drosophila melanogaster	175-179
24498361-7	2014	These data suggest that GCDH is a constituent of multimeric mitochondrial dehydrogenase complexes, and the characterization of their interrelated functions may provide new insights into the regulation of lysine oxidation and the pathophysiology of GA1.	Lysine	204-210	glutaryl-CoA dehydrogenase	Homo sapiens	24-28
24308962-2	2014	In this report we showed that TRIM50 is a target of HDAC6 with Lys-372 as a critical residue for acetylation.	Lysine	63-66	tripartite motif containing 50	Homo sapiens	30-36
24354544-1	2014	BACKGROUND: Down-regulation of fibrinolysis due to cleavage of C-terminal lysine residues from partially degraded fibrin is mainly exerted by the carboxypeptidase activity of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).	Lysine	74-80	carboxypeptidase B2 (plasma)	Mus musculus	185-228
24274971-8	2014	The half-life of Lys(30)-PEG-pGLP-2 was 16-fold longer than that of pGLP-2 in DPP-IV.	Lysine	17-20	dipeptidylpeptidase 4	Mus musculus	78-84
24397610-9	2014	Comparison of the binding modes of HsTx1 with Kv1.1 and Kv1.3 reveals that the lower affinity of HsTx1 for Kv1.1 is due to its inability to come close to the pore domain, which prevents the pore inserting lysine from making proper contacts with the tyrosine carbonyls in the selectivity filter.	Lysine	205-211	potassium voltage-gated channel subfamily A member 1	Homo sapiens	107-112
24462205-4	2014	Here, we show that asymmetric SUMOylation of a conserved lysine residue in the N domain of both yeast (K178) and human (K191) Hsp90 facilitates both recruitment of the adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90 inhibitors, suggesting that these drugs associate preferentially with Hsp90 proteins that are actively engaged in the chaperone cycle.	Lysine	57-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-131
24462205-4	2014	Here, we show that asymmetric SUMOylation of a conserved lysine residue in the N domain of both yeast (K178) and human (K191) Hsp90 facilitates both recruitment of the adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90 inhibitors, suggesting that these drugs associate preferentially with Hsp90 proteins that are actively engaged in the chaperone cycle.	Lysine	57-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	264-269
24462205-4	2014	Here, we show that asymmetric SUMOylation of a conserved lysine residue in the N domain of both yeast (K178) and human (K191) Hsp90 facilitates both recruitment of the adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90 inhibitors, suggesting that these drugs associate preferentially with Hsp90 proteins that are actively engaged in the chaperone cycle.	Lysine	57-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	264-269
24421331-3	2014	We show here that HSP27 and alphaB-crystallin associated with immunoglobulin-like (Ig) domain-containing regions, but not the disordered PEVK domain (titin region rich in proline, glutamate, valine, and lysine), of the titin springs.	Lysine	203-209	heat shock protein family B (small) member 1	Homo sapiens	18-23
24379373-6	2014	Upon viral infection, TRIM14 undergoes Lys-63-linked polyubiquitination at Lys-365 and recruits NF-kappaB essential modulator to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3 and NF-kappaB pathways.	Lysine	39-42	tripartite motif containing 14	Homo sapiens	22-28
24165275-4	2014	Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus.	Lysine	179-185	HOX transcript antisense RNA	Homo sapiens	17-23
25169498-8	2014	On stratified analysis by tumor type, XPD Lys751Gln polymorphism was not associated with increased risk of non-melanoma skin cancer, but was significantly related with increased risk of cutaneous melanoma (Gln/Gln vs Lys/Lys: OR=1.15, 95%CI=1.02-1.29, p=0.023; dominant model: OR=1.09, 95%CI=1.01-1.18, p=0.036).	Lysine	42-45	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	38-41
25169498-8	2014	On stratified analysis by tumor type, XPD Lys751Gln polymorphism was not associated with increased risk of non-melanoma skin cancer, but was significantly related with increased risk of cutaneous melanoma (Gln/Gln vs Lys/Lys: OR=1.15, 95%CI=1.02-1.29, p=0.023; dominant model: OR=1.09, 95%CI=1.01-1.18, p=0.036).	Lysine	217-220	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	38-41
24761866-7	2014	However; in subgroup analyses by cancer type, a significant association between EXO1 Glu589Lys and lung cancer risk was found (Lys vs Glu: OR=1.23, 95%CI=1.07- 1.41, p heterogeneity=0.05).	Lysine	91-94	exonuclease 1	Homo sapiens	80-84
24967351-7	2014	In the gonadal adipose tissues, combinations of DHA and lysine inhibited mRNA expression of lipid metabolism-associated genes, including ACC1, fatty acid synthase, lipoprotein lipase, and perilipin.	Lysine	56-62	acetyl-Coenzyme A carboxylase alpha	Mus musculus	137-141
24587932-1	2014	Glutaric aciduria type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism caused by deficiency of glutaryl-CoA dehydrogenase.	Lysine	70-76	glutaryl-CoA dehydrogenase	Homo sapiens	143-169
25483188-7	2014	Expression of a lysine mutant of cyclin B1 that is degraded only slightly inefficiently allowed a normal metaphase-to-anaphase transition.	Lysine	16-22	cyclin B1	Homo sapiens	33-42
24492587-4	2014	The amino acids in these positions have opposite charges in CYP2C9 and 2C19; the former has lysines in both positions (Lys72 and Lys241), and the latter has glutamic acids (Glu72 and Glu241).	Lysine	92-99	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	60-66
24803743-9	2014	Moreover, cathepsin G, but not elastase, induced aggregation on poly-L-lysine substrates which are not decomposed by these enzymes, and the action of cathepsin G was nearly completely attenuated by PMSF.	Lysine	64-77	cathepsin G	Homo sapiens	10-21
24803743-9	2014	Moreover, cathepsin G, but not elastase, induced aggregation on poly-L-lysine substrates which are not decomposed by these enzymes, and the action of cathepsin G was nearly completely attenuated by PMSF.	Lysine	64-77	cathepsin G	Homo sapiens	150-161
24247240-5	2013	Here, we show that H-Ras is activated by monoubiquitination and that ubiquitination at Lys-117 accelerates intrinsic nucleotide exchange, thereby promoting GTP loading.	Lysine	87-90	HRas proto-oncogene, GTPase	Homo sapiens	19-24
24132959-3	2013	To elucidate the mechanism of this reorganization of heterochromatin, we investigated the expression and nuclear localization of DOT1L, which is involved in the regulation of heterochromatin structure through histone H3 lysine 79 (H3K79) methyltransferase activity, during preimplantation development.	Lysine	220-226	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	129-134
24217247-8	2013	Targeted point mutations recognized that amino acids Lys-233, Glu-236, and Lys-240 in helix 10 mediate the interaction of AKR1B10 with HSP90alpha.	Lysine	53-56	heat shock protein 90 alpha family class A member 1	Homo sapiens	135-145
24217247-8	2013	Targeted point mutations recognized that amino acids Lys-233, Glu-236, and Lys-240 in helix 10 mediate the interaction of AKR1B10 with HSP90alpha.	Lysine	75-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	135-145
24240174-1	2013	The histone deacetylases HDAC1 and HDAC2 remove acetyl moieties from lysine residues of histones and other proteins and are important regulators of gene expression.	Lysine	69-75	histone deacetylase 1	Mus musculus	25-30
24115035-7	2013	Interestingly, acetylation of histone H3 at lysine 56 mediated by histone deacetylase-3 reduction was enhanced significantly in AMPKalpha2(-/-) VSMCs compared with wild-type or AMPKalpha1(-/-) VSMCs.	Lysine	44-50	histone deacetylase 3	Mus musculus	66-87
23872418-5	2013	Here, we report for the first time that sumoylation targets human ZIC3 primarily on the consensus lysine residue K248, which is critical for the nuclear retention of ZIC3.	Lysine	98-104	Zic family member 3	Homo sapiens	66-70
23872418-5	2013	Here, we report for the first time that sumoylation targets human ZIC3 primarily on the consensus lysine residue K248, which is critical for the nuclear retention of ZIC3.	Lysine	98-104	Zic family member 3	Homo sapiens	166-170
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	137-140	phosphatase and tensin homolog	Homo sapiens	65-69
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	147-150	phosphatase and tensin homolog	Homo sapiens	65-69
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	147-150	phosphatase and tensin homolog	Homo sapiens	65-69
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	147-150	phosphatase and tensin homolog	Homo sapiens	65-69
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	147-150	phosphatase and tensin homolog	Homo sapiens	65-69
23872024-9	2013	Subsequent LC/MS/MS analysis of 4-HNE-modified recombinant human PTEN identified Michael addition adducts of 4-HNE on Cys(71), Cys(136), Lys(147), Lys(223), Cys(250), Lys(254), Lys(313), Lys(327), and Lys(344).	Lysine	147-150	phosphatase and tensin homolog	Homo sapiens	65-69
24081332-1	2013	Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (complex of proteins associated with Set1) family from Saccharomyces cerevisiae to humans, and these modifications can be found at distinct regions of the genome.	Lysine	11-17	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	127-131
24129578-0	2013	Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.	Lysine	65-68	NUF2 component of NDC80 kinetochore complex	Homo sapiens	126-130
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	sirtuin 2	Mus musculus	14-19
24126913-5	2013	The arch contains basic residues (Lys-93 and Arg-100 in human FEN1 (hFEN1)) that are conserved by all 5"-nucleases and a cap region only present in enzymes that process DNAs with 5" termini.	Lysine	34-37	flap structure-specific endonuclease 1	Homo sapiens	62-66
24126913-5	2013	The arch contains basic residues (Lys-93 and Arg-100 in human FEN1 (hFEN1)) that are conserved by all 5"-nucleases and a cap region only present in enzymes that process DNAs with 5" termini.	Lysine	34-37	flap structure-specific endonuclease 1	Homo sapiens	68-73
23898905-12	2013	With the development of protein crystallography, researchers solved HMGR crystal structures to reveal an unexpected lysine residue at the center of the active site.	Lysine	116-122	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	68-72
24003859-9	2013	When these two residues in AtTrx-h3 were replaced with lysine, AtTrx-h3 functioned like AtTrx-h2.	Lysine	55-61	thioredoxin 2	Arabidopsis thaliana	88-96
24207025-5	2013	Mutation of lysines or p300 inhibitor treatment causes the loss of epidermal growth-factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused polymerases, but does not affect expression or polymerase occupancy at housekeeping genes.	Lysine	12-19	epidermal growth factor	Homo sapiens	67-90
24207025-5	2013	Mutation of lysines or p300 inhibitor treatment causes the loss of epidermal growth-factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused polymerases, but does not affect expression or polymerase occupancy at housekeeping genes.	Lysine	12-19	early growth response 2	Homo sapiens	123-127
23948433-6	2013	Chromatin immunoprecipitation (ChIP) analysis confirmed the alterations of di-methylated lysine 36 of histone H3 (H3K36me2) in the coding region of cyclin A1.	Lysine	89-95	cyclin A1	Homo sapiens	148-157
24054699-5	2013	The unexpected molecular weights of POT1 seem to be associated with SUMO1 and ubiquitin conjugation; the latter occurring at a double lysine residue at 289-KK-290.	Lysine	134-140	protection of telomeres 1	Homo sapiens	36-40
23970103-3	2013	Herein, we report that KDM5B is SUMOylated at lysine residues 242 and 278 and that the ectopic expression of the hPC2 SUMO E3 ligase enhances this SUMOylation.	Lysine	46-52	chromobox 4	Homo sapiens	113-117
24100389-3	2013	Recent studies focusing on the post-translational modification of TLR4 signaling pathways have begun expanding our knowledge of the impact of lysine acetylation on TLR4 signaling cascades.	Lysine	142-148	toll like receptor 4	Homo sapiens	66-70
24100389-3	2013	Recent studies focusing on the post-translational modification of TLR4 signaling pathways have begun expanding our knowledge of the impact of lysine acetylation on TLR4 signaling cascades.	Lysine	142-148	toll like receptor 4	Homo sapiens	164-168
24240169-0	2013	KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.	Lysine	68-74	lysine methyltransferase 2D	Homo sapiens	0-5
24038880-5	2013	In order to gain a better understanding of the possible function(s) of the Pro-Lys (PK) sequence at positions 3 and 4 of yeast Rpt1, we generated mutant strains expressing an Rpt1 allele that lacks this sequence.	Lysine	79-82	proteasome regulatory particle base subunit RPT1	Saccharomyces cerevisiae S288C	127-131
16546250-2	2006	G3-PLLs having various oligo(L-lysine) (PLL) segment (n = 5-40) were successfully synthesized by graft-polymerization of L-lysine NCA initiated with amino groups at the 3rd-generation poly(amidoamine) dendrimer surface.	Lysine	121-129	CEA cell adhesion molecule 6	Homo sapiens	130-133
16543150-3	2006	We find a stable association of the histone H4 lysine 16-specific acetyltransferase MOF with the RNA/protein containing MSL complex as well as with an evolutionary conserved complex.	Lysine	47-53	males absent on the first	Drosophila melanogaster	84-87
16540651-5	2006	Nuclear IGFBP-3 is highly polyubiquitinated at multiple lysine residues in its conserved COOH-terminal domain and stabilized through mutation of two COOH-terminal lysine residues.	Lysine	56-62	insulin like growth factor binding protein 3	Homo sapiens	8-15
16540651-5	2006	Nuclear IGFBP-3 is highly polyubiquitinated at multiple lysine residues in its conserved COOH-terminal domain and stabilized through mutation of two COOH-terminal lysine residues.	Lysine	163-169	insulin like growth factor binding protein 3	Homo sapiens	8-15
16325371-3	2006	SMCP can now be reliably identified by its tripartite structure including a short amino-terminal segment; a central segment containing short tandem repeats rich in cysteine, proline, glutamine, and lysine; and a C-terminal segment containing no repeats, few cysteines, and a C-terminal lysine.	Lysine	198-204	sperm mitochondria associated cysteine rich protein	Homo sapiens	0-4
16325371-3	2006	SMCP can now be reliably identified by its tripartite structure including a short amino-terminal segment; a central segment containing short tandem repeats rich in cysteine, proline, glutamine, and lysine; and a C-terminal segment containing no repeats, few cysteines, and a C-terminal lysine.	Lysine	286-292	sperm mitochondria associated cysteine rich protein	Homo sapiens	0-4
16319397-8	2006	For the replacement histone H2AZ, acetylation at Lys-4 and Lys-7 was found.	Lysine	49-52	H2A.Z variant histone 1	Homo sapiens	28-32
16319397-8	2006	For the replacement histone H2AZ, acetylation at Lys-4 and Lys-7 was found.	Lysine	59-62	H2A.Z variant histone 1	Homo sapiens	28-32
16319397-9	2006	The main histone H2B variant, H2BA, was acetylated at Lys-12, -15, and -20.	Lysine	54-57	H2B clustered histone 21	Homo sapiens	17-20
16319071-3	2006	Ets-1 is modified in vivo predominantly at a consensus sumoylation motif containing Lys-15.	Lysine	84-87	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-5
16319071-4	2006	This lysine is located within the unstructured N-terminal segment of Ets-1 preceding its PNT domain.	Lysine	5-11	ETS proto-oncogene 1, transcription factor	Homo sapiens	69-74
16467571-2	2006	To investigate the in vivo importance of LH3-catalyzed lysine hydroxylation and hydroxylysine-linked glycosylations, three different LH3-manipulated mouse lines were generated.	Lysine	55-61	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	41-44
16476163-8	2006	Structural modeling suggested that six lysines per VP2 subunit are presumably addressable for bioconjugation on the CPV capsid exterior.	Lysine	39-46	VP2	Canine parvovirus	51-54
16427628-2	2006	We showed that all RET-PTC-1 mutants in which the C in this motif (C376) was replaced with glycine, lysine, threonine or serine lost their activity in vitro.	Lysine	100-106	ret proto-oncogene	Homo sapiens	19-22
16470308-1	2006	Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH.	Lysine	152-158	carboxypeptidase M	Homo sapiens	0-18
16470308-1	2006	Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH.	Lysine	152-158	carboxypeptidase M	Homo sapiens	20-23
16518696-3	2006	The catalysis of lysine-63 linked polyubiquitin chains involves the sequential activity of three enzymes (E1, E2, and E3) that ultimately transfer a ubiquitin thiolester intermediate to a protein target.	Lysine	17-23	small nucleolar RNA, H/ACA box 73A	Homo sapiens	106-120
16518696-4	2006	The E2 responsible for catalysis of lysine-63 linked polyubiquitination is a protein heterodimer consisting of a canonical E2 known as Ubc13, and an E2-like protein, or ubiquitin conjugating enzyme variant (UEV), known as Mms2.	Lysine	36-42	ubiquitin conjugating enzyme E2 N	Homo sapiens	135-140
16518696-4	2006	The E2 responsible for catalysis of lysine-63 linked polyubiquitination is a protein heterodimer consisting of a canonical E2 known as Ubc13, and an E2-like protein, or ubiquitin conjugating enzyme variant (UEV), known as Mms2.	Lysine	36-42	ubiquitin conjugating enzyme E2 V2	Homo sapiens	222-226
16518696-6	2006	The structure of the Mms2-Ub complex provides important insights into the molecular basis underlying the catalysis of lysine-63 linked polyubiquitin chains.	Lysine	118-124	ubiquitin conjugating enzyme E2 V2	Homo sapiens	21-25
16415881-3	2006	Collectively, our data reveal that SET7/9 recognizes a conserved K/R-S/T/A motif preceding the lysine substrate and has a propensity to bind aspartates and asparagines on the C-terminal side of the lysine target.	Lysine	95-101	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	35-41
16415881-3	2006	Collectively, our data reveal that SET7/9 recognizes a conserved K/R-S/T/A motif preceding the lysine substrate and has a propensity to bind aspartates and asparagines on the C-terminal side of the lysine target.	Lysine	198-204	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	35-41
16472284-4	2006	DNA samples were genotyped for the nucleotide 2690 A&gt;C variation of the KCNH2 gene, corresponding to the KCNH2 K(lysine)897T(threonine) amino acid polymorphism.	Lysine	116-122	potassium voltage-gated channel subfamily H member 2	Homo sapiens	75-80
16472284-4	2006	DNA samples were genotyped for the nucleotide 2690 A&gt;C variation of the KCNH2 gene, corresponding to the KCNH2 K(lysine)897T(threonine) amino acid polymorphism.	Lysine	116-122	potassium voltage-gated channel subfamily H member 2	Homo sapiens	108-113
16399501-4	2006	Upon sterol deprivation, the Scap/SREBP complex dissociates from Insig-1, which is then ubiquitinated on lysines 156 and 158 and degraded in proteasomes.	Lysine	105-112	insulin induced gene 1	Homo sapiens	65-72
17464364-0	2006	Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2.	Lysine	30-36	methyl CpG binding protein 2	Mus musculus	108-113
17464364-5	2006	Using an antibody specific to acetylated histone H3 lysine 9 (H3K9ac), a bright punctate nuclear staining pattern was observed as MECP2 expression increased in early postnatal neuronal nuclei.	Lysine	52-58	methyl CpG binding protein 2	Mus musculus	130-135
17464364-8	2006	In contrast, trimethylated histone H3 lysine 9 (H3K9me3) localized to heterochromatin independent of MeCP2, but showed significantly reduced levels in Mecp2 deficient mouse and RTT brain.	Lysine	38-44	methyl CpG binding protein 2	Mus musculus	151-156
16267042-5	2005	Here we provide evidence that the T loop-proximal residue Lys-163 in IKKbeta serves as a major site for signal-induced monoubiquitination with significant regulatory potential.	Lysine	58-61	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	69-76
16267042-7	2005	Phosphopeptide mapping experiments revealed that the Lys-163 --&gt; Arg mutation also interferes with proper in vivo but not in vitro phosphorylation of cytokine-responsive serine residues located in the distal C-terminal region of IKKbeta.	Lysine	53-56	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	232-239
16267042-8	2005	Taken together, these data indicate that chronic phosphorylation of IKKbeta at Ser-177/Ser-181 leads to monoubiquitin attachment at nearby Lys-163, which in turn modulates the phosphorylation status of IKKbeta at select C-terminal serines.	Lysine	139-142	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	68-75
16267042-8	2005	Taken together, these data indicate that chronic phosphorylation of IKKbeta at Ser-177/Ser-181 leads to monoubiquitin attachment at nearby Lys-163, which in turn modulates the phosphorylation status of IKKbeta at select C-terminal serines.	Lysine	139-142	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	202-209
16357144-6	2005	Induction of MLL fusion protein activity is associated with increased levels of histone acetylation and Lys(4) methylation at Hox target genes.	Lysine	104-107	lysine methyltransferase 2A	Homo sapiens	13-16
16357144-7	2005	In addition, the MLL-ENL-ER protein, but not dimerized MLL, also induces dimethylation of histone H3 at Lys(79), suggesting alternative mechanisms for transcriptional activation.	Lysine	104-107	lysine methyltransferase 2A	Homo sapiens	17-20
16306263-8	2005	These studies demonstrate that the folic acid conjugation to the Lys side-chain amino groups blocks binding to the normal LDL receptor and reroutes the resulting conjugate to cancer cells through their FRs.	Lysine	65-68	low density lipoprotein receptor	Homo sapiens	122-134
24074567-4	2013	Here, we conjugated a TLR7/8 ligand to lysine residues on gp120 using NHS-PEO8-maleimide linkers and investigated if this affected Ab recognition of the CD4 binding site (CD4bs), a highly conserved target for bNAbs.	Lysine	39-45	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	58-63
24070375-6	2013	ChIP/QPCR (chromatin immunoprecipitation/quantitative PCR) assays demonstrated enrichment of Rnf2, H2AK119 (mono-ubiquitinated histone H2A lysine 119), and H3K27me3 (histone H3 lysine 27 trimethylated), a PRC2 chromatin mark, at multiple alpha-ENaC promoter subregions corresponding to regions of known Af9 enrichment, under basal conditions.	Lysine	177-183	ring finger protein 2	Mus musculus	93-97
23974797-9	2013	Ambra1 is an E3 ligase for lysine 63-linked ubiquitination of Beclin 1 that is required for starvation-induced autophagy.	Lysine	27-33	autophagy and beclin 1 regulator 1	Homo sapiens	0-6
2478364-3	1989	This was characterized by the extent to which a polysaccharide could protect chemical modification of Lys-125 and Lys-136, two lysyl residues of antithrombin which have been implicated in heparin binding.	Lysine	114-117	serpin family C member 1	Homo sapiens	145-157
16261261-2	2005	Consistent with the hypothesis that post-translational modifications of histones may functionally "mark" DNA sequences, HP1 was found to bind to "silent" chromatin via the methylated lysine 9 (K9) residue on the histone H3 tail that protrudes from the nucleosome.	Lysine	183-189	chromobox 5	Homo sapiens	120-123
2478364-9	1989	These data clearly demonstrate that the heparin and pentosan polysulfate binding sites of antithrombin overlap (at Lys-125) but are not identical.	Lysine	115-118	serpin family C member 1	Homo sapiens	90-102
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Lysine	147-150	PCNA clamp associated factor	Homo sapiens	88-91
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Lysine	147-150	PCNA clamp associated factor	Homo sapiens	186-189
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Lysine	147-150	PCNA clamp associated factor	Homo sapiens	186-189
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Lysine	147-150	PCNA clamp associated factor	Homo sapiens	186-189
16263756-4	2005	Relevant key features of SIMP/STT3B are its lysine-rich region, its propensity to misfold and its location in the ER membrane in close proximity to the immunoproteasome.	Lysine	44-50	STT3 oligosaccharyltransferase complex catalytic subunit B	Homo sapiens	30-35
2506440-5	1989	Mutation of the lysine residue (but not of the glycine residue) resulted in the loss of [alpha-32P]dATP cross-linking to eIF-4A, suggesting that the lysine is an important determinant in ATP binding to eIF-4A.	Lysine	149-155	eukaryotic translation initiation factor 4A2	Homo sapiens	121-127
16287840-4	2005	We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain.	Lysine	193-199	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-37
16287840-4	2005	We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain.	Lysine	193-199	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-106
16287840-4	2005	We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain.	Lysine	193-199	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-106
2506440-5	1989	Mutation of the lysine residue (but not of the glycine residue) resulted in the loss of [alpha-32P]dATP cross-linking to eIF-4A, suggesting that the lysine is an important determinant in ATP binding to eIF-4A.	Lysine	149-155	eukaryotic translation initiation factor 4A2	Homo sapiens	202-208
2668284-6	1989	However, the replacement of the activation peptide with an 8-residue sequence (Pro-Arg-Pro-Ser-Arg-Lys-Arg-Arg) involved in the proteolytic processing of the human insulin receptor precursor resulted in the direct expression of fully activated protein C.	Lysine	99-102	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	244-253
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	48-54	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	48-54	defensin alpha 1	Homo sapiens	187-190
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	102-108	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	102-108	defensin alpha 1	Homo sapiens	187-190
23974119-7	2013	Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.	Lysine	186-193	proprotein convertase subtilisin/kexin type 9	Mus musculus	144-149
24088713-3	2013	SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1.	Lysine	67-73	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	8-13
24088713-3	2013	SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1.	Lysine	67-73	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	15-19
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Lysine	103-109	carboxypeptidase E	Homo sapiens	31-49
23770285-3	2013	Here we report that Sef-S physically interacts with TAK1, induces Lys63-linked TAK1 polyubiquitination on lysine 209 and TAK1-mediated JNK and p38 activation.	Lysine	106-112	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	52-56
23770285-3	2013	Here we report that Sef-S physically interacts with TAK1, induces Lys63-linked TAK1 polyubiquitination on lysine 209 and TAK1-mediated JNK and p38 activation.	Lysine	106-112	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	79-83
23770285-3	2013	Here we report that Sef-S physically interacts with TAK1, induces Lys63-linked TAK1 polyubiquitination on lysine 209 and TAK1-mediated JNK and p38 activation.	Lysine	106-112	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	79-83
23770285-6	2013	These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells.	Lysine	75-81	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	48-52
16144832-5	2005	Pias1 binding to mGluR8-C required a region N-terminal to a consensus sumoylation motif and was not affected by arginine substitution of the conserved lysine 882 within this motif.	Lysine	151-157	protein inhibitor of activated STAT 1	Homo sapiens	0-5
16236769-3	2005	Here we characterize cis-acting targeting sequences in the LIN-12 intracellular domain and find that in addition to a di-leucine motif, serine/threonine residues are important for internalization and lysine residues are important for post-internalization trafficking and degradation.	Lysine	200-206	lin-12/Notch intracellular domain	Caenorhabditis elegans	59-65
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Lysine	103-109	carboxypeptidase E	Homo sapiens	51-58
2552329-4	1989	In accordance, increases in intracellular cyclic GMP by sodium nitroprusside and EDRF were attenuated by LY 83583.	Lysine	105-107	alpha hemoglobin stabilizing protein	Homo sapiens	81-85
16246731-0	2005	Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling.	Lysine	0-6	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	65-69
16118210-8	2005	Further deletion analyses identified at least 3 lysine residues within the Xic1 C terminus that are targeted for specific ubiquitination.	Lysine	48-54	cyclin-dependent kinase inhibitor xic1 L homeolog	Xenopus laevis	75-79
23959799-4	2013	Our data unambiguously demonstrate that Smurf1 ubiquitinates axin through Lys 29 (K29)-linked polyubiquitin chains.	Lysine	74-77	SMAD specific E3 ubiquitin protein ligase 1	Mus musculus	40-46
24056301-4	2013	We found that whereas GTP binding turns on RALB activity, ubiquitylation of RALB at Lys 47 tunes its activity towards a particular effector.	Lysine	84-87	RAS like proto-oncogene B	Homo sapiens	76-80
24056301-5	2013	Specifically, ubiquitylation at Lys 47 sterically inhibits RALB binding to EXO84, while facilitating its interaction with SEC5.	Lysine	32-35	RAS like proto-oncogene B	Homo sapiens	59-63
16126174-0	2005	Six lysine residues on c-Myc are direct substrates for acetylation by p300.	Lysine	4-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	23-28
2777004-4	1989	It turned out that TP1 is a small, but very basic protein with 54 amino acids (21% arginine, 19% lysine) and is highly conserved during mammalian evolution at the nucleotide as well as at the amino-acid level.	Lysine	97-103	transition protein 1	Homo sapiens	19-22
16126174-6	2005	These analyses identify six lysine residues in human Myc (K143, K157, K275, K317, K323, and K371) as direct substrates for p300.	Lysine	28-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	53-56
16194093-0	2005	Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.	Lysine	149-156	RAN binding protein 2	Homo sapiens	160-166
24046422-7	2013	Breed-specific epigenetic modifications of the PEPCK-c promoter were also observed; the fast-growing breed demonstrated lower CpG methylation (P &lt; 0.05) and histone H3 (P &lt; 0.05) levels but more histone H3 acetylation (H3ac) and histone H3 lysine 27 trimethylation (H3K27me3; P &lt; 0.05) compared with the slow-growing breed.	Lysine	246-252	phosphoenolpyruvate carboxykinase 1	Gallus gallus	47-54
23973329-5	2013	In addition, the TGF-beta receptor-TRAF4 interaction triggers Lys 63-linked TRAF4 polyubiquitylation and subsequent activation of the TGF-beta-activated kinase (TAK)1.	Lysine	62-65	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	134-166
2570065-0	1989	Site-specific mutagenesis of lysine-204, tyrosine-224, tyrosine-228, and histidine-307 of porcine kidney D-amino acid oxidase and the implications as to its catalytic function.	Lysine	29-35	D-amino acid oxidase	Homo sapiens	105-125
24036492-1	2013	Sir2, a member of the sirtuin family of protein acylases, deacetylates lysine residues within many proteins and is associated with lifespan extension in a variety of model organisms.	Lysine	71-77	Sirtuin 1	Drosophila melanogaster	0-4
16186386-0	2005	BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.	Lysine	74-80	neuronal differentiation 1	Homo sapiens	0-12
16142216-6	2005	ASK 1(3M), an ASK 1 mutant in which all three lysines in the psiKXE motif were substituted with alanines, still retained the kinase activity and activated the Jun amino-terminal kinase pathway.	Lysine	46-53	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-5
2570065-1	1989	In order to evaluate the possible contributions of Lys-204, Tyr-224, Tyr-228, and His-307 in porcine kidney D-amino acid oxidase [EC 1.4.3.3] (DAO) to its catalytic function, we constructed four point mutant cDNAs encoding enzymes possessing Glu-204, Phe-224, Phe-228, and Leu-307 by oligonucleotide-directed in vitro mutagenesis.	Lysine	51-54	D-amino acid oxidase	Homo sapiens	108-128
16166626-3	2005	Mutations that affect Dot1 function such as Rad6-Bre1/Paf1 pathway gene deletions or mutation of H2B Lys 123 or H3 Lys 79 share dot1Delta checkpoint defects.	Lysine	101-104	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	44-48
23414300-0	2013	Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.	Lysine	24-30	H3.3 histone A	Homo sapiens	161-166
23414300-1	2013	H3F3A mutations are seen in ~30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V).	Lysine	89-95	H3.3 histone A	Homo sapiens	0-5
16166626-8	2005	Mutation of Rad9 to alter tudor domain binding to methylated Lys 79 phenocopies the dot1Delta checkpoint defect and blocks Rad53 phosphorylation.	Lysine	61-64	chromatin-binding protein RAD9	Saccharomyces cerevisiae S288C	12-16
2472353-6	1989	The 600 glycine and the 601 lysine were involved in the binding of all IgG1, 2 and 4 and most IgG3.	Lysine	28-34	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	94-98
16166628-6	2005	Importantly, HDAC4 promotes sumoylation on a lysine residue that is also subject to acetylation by a MEF2 coactivator, the acetyltransferase CBP, suggesting a possible interplay between acetylation and sumoylation in regulating MEF2 activity.	Lysine	45-51	histone deacetylase 4	Homo sapiens	13-18
16168379-1	2005	The Set1-containing complex COMPASS, which is the yeast homolog of the human MLL complex, is required for mono-, di-, and trimethylation of lysine 4 of histone H3.	Lysine	140-146	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	4-8
16168379-1	2005	The Set1-containing complex COMPASS, which is the yeast homolog of the human MLL complex, is required for mono-, di-, and trimethylation of lysine 4 of histone H3.	Lysine	140-146	lysine methyltransferase 2A	Homo sapiens	77-80
23707529-6	2013	Here we show that the presenilin full-length holoproteins are novel substrates of TRAF6-mediated Lysine-63-linked ubiquitination.	Lysine	97-103	TNF receptor associated factor 6	Homo sapiens	82-87
2708351-11	1989	As a result, it was concluded that the C terminus of the 66,000-dalton, 64,000-dalton, and 61,000-dalton MLC kinase fragments are arginine 522, lysine 490 and arginine 494, and lysine 473, respectively.	Lysine	144-150	myosin light chain kinase	Homo sapiens	105-115
23852375-7	2013	We then demonstrate that Spi-1 represses Bim transcription by binding to the Bim promoter and by promoting the trimethylation of histone 3 on lysine 27 (H3K27me3, a repressive histone mark) on the Bim promoter.	Lysine	142-148	Spi-1 proto-oncogene	Homo sapiens	25-30
23673479-7	2013	In total, significantly increased risk of developing lung cancer was found in the following combinations of genotypes: XPD Lys/Gln+XPC Lys/Lys (OR = 1.62; p = 0.04), XRCC1 Gln/Gln+hOGG1 Ser/Ser (OR = 2.14; p = 0.02).	Lysine	123-126	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	119-122
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	115-118	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	111-114
16131544-2	2005	Competitive binding analysis and mutagenesis reveals a unique BTLA binding site centered on a critical lysine residue in cysteine-rich domain 1 of HVEM.	Lysine	103-109	B and T lymphocyte associated	Homo sapiens	62-66
15987677-4	2005	Here we report that DEK undergoes acetylation in vivo at lysine residues within the first 70 N-terminal amino acids.	Lysine	57-63	DEK proto-oncogene	Homo sapiens	20-23
2708351-11	1989	As a result, it was concluded that the C terminus of the 66,000-dalton, 64,000-dalton, and 61,000-dalton MLC kinase fragments are arginine 522, lysine 490 and arginine 494, and lysine 473, respectively.	Lysine	177-183	myosin light chain kinase	Homo sapiens	105-115
16143104-6	2005	We find that Set1 is required for methylation of conserved lysines in a kinetochore protein, Dam1.	Lysine	59-66	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	13-17
2495940-15	1989	Limited trypsinolytic cleavage, previously shown to occur at Lys-292, removed cross-linking in UCP both in the solubilized and mitochondrially bound state.	Lysine	61-64	uncoupling protein 1	Homo sapiens	95-98
16135786-6	2005	Multiple site-specific lysine acetylation of H3/H4 is associated with such LHR gene activation.	Lysine	23-29	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	75-78
16135789-2	2005	Acetylation at lysines 218, 221, and 310 differentially regulates RelA"s DNA binding activity, assembly with IkappaBalpha, and transcriptional activity.	Lysine	15-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	66-70
23965803-3	2013	Although mdig can only cause a marginal decrease of the total histone H3 lysine 9 trimethylation (H3K9me3), a significant reduction of H3K9me3 in the promoter region of H19, the paternally imprinted but maternally expressed gene transcribing a large intergenic non-coding RNA (lincRNA), was observed in the cells with mdig overexpression.	Lysine	73-79	ribosomal oxygenase 2	Homo sapiens	9-13
2492530-0	1989	Binding of heparin to human antithrombin III activates selective chemical modification at lysine 236.	Lysine	90-96	serpin family C member 1	Homo sapiens	28-44
23903439-1	2013	NEDD8 (NEURAL PRECURSOR CELL-EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED PROTEIN8) is an evolutionarily conserved 8-kD protein that is closely related to ubiquitin and that can be conjugated like ubiquitin to specific lysine residues of target proteins in eukaryotes.	Lysine	216-222	related to ubiquitin 1	Arabidopsis thaliana	0-5
15927960-8	2005	Indeed, delta(389-418) carrying four lysine-to-alanine substitutions (delta(389-418) K387A/K428A/K442A/K445A) was as stable as delta(358-452) c-Myb.	Lysine	37-43	myeloblastosis oncogene	Mus musculus	142-147
2492530-1	1989	Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of antithrombin III.	Lysine	0-3	serpin family C member 1	Homo sapiens	78-94
23798683-0	2013	Quantitative dissection of the binding contributions of ligand lysines of the receptor-associated protein (RAP) to the low density lipoprotein receptor-related protein (LRP1).	Lysine	63-70	LDL receptor related protein associated protein 1	Homo sapiens	78-105
2492530-1	1989	Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of antithrombin III.	Lysine	9-12	serpin family C member 1	Homo sapiens	78-94
23798683-0	2013	Quantitative dissection of the binding contributions of ligand lysines of the receptor-associated protein (RAP) to the low density lipoprotein receptor-related protein (LRP1).	Lysine	63-70	LDL receptor related protein associated protein 1	Homo sapiens	107-110
2492530-1	1989	Lys-107, Lys-125, and Lys-136 are situated within the heparin-binding site of antithrombin III.	Lysine	9-12	serpin family C member 1	Homo sapiens	78-94
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	85-92	LDL receptor related protein associated protein 1	Homo sapiens	162-189
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	94-97	LDL receptor related protein associated protein 1	Homo sapiens	162-189
16040246-3	2005	In yeast, histone H3 lysine 4 (K4) is mono-, di-, and trimethylated by the Set1 histone methyltransferase.	Lysine	21-27	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	75-79
2492530-2	1989	A new water-soluble color reagent, 4-N,N-dimethylaminoazobenzene-4"-isothiocyano-2"-sulfonic acid (S-DABITC), was used to identify lysine residues of antithrombin III which participate in the binding of heparin.	Lysine	131-137	serpin family C member 1	Homo sapiens	150-166
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	103-106	LDL receptor related protein associated protein 1	Homo sapiens	162-189
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	103-106	LDL receptor related protein associated protein 1	Homo sapiens	162-189
2492530-9	1989	Thus, binding of heparin to human antithrombin diminished S-DABITC modification at Lys-107, Lys-125, and Lys-136, but at the same time enhanced S-DABITC modification at Lys-236.	Lysine	83-86	serpin family C member 1	Homo sapiens	34-46
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	103-106	LDL receptor related protein associated protein 1	Homo sapiens	162-189
23798683-2	2013	To resolve this paradox, we have examined the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the third domain (D3) of receptor-associated protein (RAP), by eliminating all other lysine residues.	Lysine	85-91	LDL receptor related protein associated protein 1	Homo sapiens	162-189
16103223-1	2005	Trimethylation of histone H3 lysine 9 and the subsequent binding of heterochromatin protein 1 (HP1) mediate the formation and maintenance of pericentromeric heterochromatin.	Lysine	29-35	chromobox 5	Homo sapiens	95-98
2492530-9	1989	Thus, binding of heparin to human antithrombin diminished S-DABITC modification at Lys-107, Lys-125, and Lys-136, but at the same time enhanced S-DABITC modification at Lys-236.	Lysine	92-95	serpin family C member 1	Homo sapiens	34-46
2912694-11	1989	These observations together suggest that lysine residues in H4 and H3 are essential for the binding of ASTP to histone.	Lysine	41-47	glycerol kinase	Rattus norvegicus	103-107
15964832-2	2005	In Saccharomyces cerevisiae, Set1 has been identified as the sole histone methyltransferase required for histone H3 lysine 4 (Lys(4)) methylation.	Lysine	116-122	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	29-33
15964832-2	2005	In Saccharomyces cerevisiae, Set1 has been identified as the sole histone methyltransferase required for histone H3 lysine 4 (Lys(4)) methylation.	Lysine	126-129	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	29-33
23941555-4	2013	Ctf7 contains an acetyltransferase domain and a zinc finger motif and acetylates conserved lysine residues in the Smc3 subunit of cohesin.	Lysine	91-97	structural maintenance of chromosome 3	Arabidopsis thaliana	114-118
2492279-1	1989	Protein synthesis initiation factor 4D (eIF-4D) from mammalian cells contains the post-translationally modified lysine derivative hypusine.	Lysine	112-118	eukaryotic translation initiation factor 5A	Homo sapiens	36-38
23904486-0	2013	Relocating the active-site lysine in rhodopsin and implications for evolution of retinylidene proteins.	Lysine	27-33	rhodopsin	Bos taurus	37-46
23908241-3	2013	SIRT2 associates with the transcription start site of a subset of genes repressed during infection and deacetylates histone H3 on lysine 18 (H3K18).	Lysine	130-136	sirtuin 2	Mus musculus	0-5
15918681-9	2005	A large conformational departure from the crystallographic data is observed for two lysine residues at the binding site of selectinE.	Lysine	84-90	selectin E	Homo sapiens	123-132
2492279-1	1989	Protein synthesis initiation factor 4D (eIF-4D) from mammalian cells contains the post-translationally modified lysine derivative hypusine.	Lysine	112-118	eukaryotic translation initiation factor 5A	Homo sapiens	40-46
15950946-3	2005	A MORi3 peptide with a Lys &gt; Ala substitution--shown to reduce CaM-binding of intact MOR--bound fivefold less avidly than the wild-type peptide.	Lysine	23-26	opioid receptor mu 1	Homo sapiens	2-5
2521222-7	1989	The Pg reactive species in a plasmin-treated IgG digest was identified as the Fab fragment by chromatography utilizing the immobilized high affinity lysine-binding site of plasminogen.	Lysine	149-155	FA complementation group B	Homo sapiens	78-81
16026159-6	2005	Affinity probing of IL-1ra with methyl acetyl phosphate (MAP) in combination with proteolytic digestion and mass spectral analysis show that an anion-binding site location on the IL-1ra surface is contributed by lysine-93 and lysine-96 of the loop 84-98 as well as by lysine-6 of the unstructured N-terminal region 1-7.	Lysine	212-218	interleukin 1 receptor antagonist	Homo sapiens	20-26
16026159-6	2005	Affinity probing of IL-1ra with methyl acetyl phosphate (MAP) in combination with proteolytic digestion and mass spectral analysis show that an anion-binding site location on the IL-1ra surface is contributed by lysine-93 and lysine-96 of the loop 84-98 as well as by lysine-6 of the unstructured N-terminal region 1-7.	Lysine	212-218	interleukin 1 receptor antagonist	Homo sapiens	179-185
16026159-6	2005	Affinity probing of IL-1ra with methyl acetyl phosphate (MAP) in combination with proteolytic digestion and mass spectral analysis show that an anion-binding site location on the IL-1ra surface is contributed by lysine-93 and lysine-96 of the loop 84-98 as well as by lysine-6 of the unstructured N-terminal region 1-7.	Lysine	226-232	interleukin 1 receptor antagonist	Homo sapiens	179-185
23229652-7	2013	In the cyanate treatment group, of the twenty amino acids, phenylalanine, valine, tryptophan, threonine, and lysine prevented the structural modification of erythropoietin, according to Western blot analysis.	Lysine	109-115	erythropoietin	Rattus norvegicus	157-171
23229652-9	2013	As for the cyanate with erythropoietin treatment group, only lysine and albumin prevented the loss of biological activity of erythropoietin in the rats.	Lysine	61-67	erythropoietin	Rattus norvegicus	125-139
16026159-6	2005	Affinity probing of IL-1ra with methyl acetyl phosphate (MAP) in combination with proteolytic digestion and mass spectral analysis show that an anion-binding site location on the IL-1ra surface is contributed by lysine-93 and lysine-96 of the loop 84-98 as well as by lysine-6 of the unstructured N-terminal region 1-7.	Lysine	226-232	interleukin 1 receptor antagonist	Homo sapiens	179-185
23229652-10	2013	CONCLUSION: The results of this study suggest that lysine and albumin may play a protective role against renal anemia by erythropoietin carbamoylation in chronic renal failure.	Lysine	51-57	erythropoietin	Rattus norvegicus	121-135
2521222-9	1989	These data suggest that Pg binds to the new COOH-terminal lysine residue of the plasmin-derived Fab.	Lysine	58-64	FA complementation group B	Homo sapiens	96-99
2535032-0	1989	The modification of essential lysine residues for actin binding of myosin subfragment-1 by pyridoxal-5"-phosphate.	Lysine	30-36	myosin heavy chain 14	Homo sapiens	67-73
23884607-4	2013	Depletion of TH2B induces compensatory mechanisms that permit histone removal by up-regulating H2B and programming nucleosome instability through targeted histone modifications, including lysine crotonylation and arginine methylation.	Lysine	188-194	H2B clustered histone 1	Mus musculus	13-17
16006521-0	2005	The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.	Lysine	15-22	transformation related protein 53	Mus musculus	33-36
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	104-107	CD244 molecule	Homo sapiens	126-130
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	157-160	CD244 molecule	Homo sapiens	126-130
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	157-160	CD244 molecule	Homo sapiens	196-200
16002700-9	2005	Binding of CD48-Fc fusion protein to RNK-16 cells stably transfected with wild-type and a double-mutant Lys(68)Ala-Glu(70)Ala h2B4 further demonstrated that Lys(68) and Glu(70) in the V domain of h2B4 are essential for 2B4/CD48 interaction.	Lysine	157-160	CD244 molecule	Rattus norvegicus	127-130
23727580-8	2013	We also show that increased HDAC6 activity resulting from ROCK signaling activation reduced beta-catenin acetylation at Lys-49, which was also accompanied by its decreased phosphorylation by Caesin kinase 1 (CK1) and Glycogen synthase kinase 3beta (GSK3beta), thus preventing its proteasomal degradation.	Lysine	120-123	catenin beta 1	Homo sapiens	92-104
2535032-1	1989	Myosin subfragment-1 was modified with pyridoxal-5"-phosphate, a lysine modifying agent.	Lysine	65-71	myosin heavy chain 14	Homo sapiens	0-6
2789522-4	1989	When proteins were compared on an "equi-lysine" basis under non-reducing conditions, G-actin was found to preferentially compete with albumin for binding to acetaldehyde.	Lysine	40-46	actin	Oryctolagus cuniculus	87-92
23542007-6	2013	These observations are consistent with stabilization of the native NEIL1 structure via intramolecular, mostly electrostatic, interactions that were disrupted by mutating a positively charged (Lys-rich) cluster of residues (amino acids 355-360) near the C-terminus.	Lysine	192-195	nei like DNA glycosylase 1	Homo sapiens	67-72
23760478-3	2013	How ubiquitin recruits 53BP1 to break sites remains unknown as its relocalization involves recognition of histone H4 Lys 20 (H4K20) methylation by its Tudor domain.	Lysine	117-120	tumor protein p53 binding protein 1	Homo sapiens	23-28
23760478-5	2013	We show that 53BP1 recognizes mononucleosomes containing dimethylated H4K20 (H4K20me2) and H2A ubiquitinated on Lys 15 (H2AK15ub), the latter being a product of RNF168 action on chromatin.	Lysine	112-115	tumor protein p53 binding protein 1	Homo sapiens	13-18
15878871-11	2005	Lys(114), like Leu(176), was implicated in binding to FcgammaRI, but not FcgammaRIIa.	Lysine	0-3	Fc gamma receptor Ia	Homo sapiens	54-63
15878871-12	2005	Single mutations at amino acid positions Lys(114), Asp(169), Thr(173), Tyr(175), and Leu(176) affected C1q binding to CRP.	Lysine	41-44	complement C1q A chain	Homo sapiens	103-106
15972587-4	2005	DMP1 and BSP, each containing both glutamine and lysine residues critical for crosslink formation, readily formed polymers in vitro when incubated with TG2.	Lysine	49-55	dentin matrix acidic phosphoprotein 1	Homo sapiens	0-4
2494434-9	1989	The unique susceptibility of rat monoclonal IgG1 and IgG2a is likely to be the result of the presence of a lysine residue in a loop of C gamma 1 domain, which therefore is accessible to trypsin.	Lysine	107-113	immunoglobulin heavy variable V1-9	Mus musculus	53-58
15929062-3	2005	In this work, we induced P19 aggregates for 4 days with RA and plated them onto tissue culture dishes coated with poly-L-lysine.	Lysine	114-127	interleukin 23 subunit alpha	Homo sapiens	25-28
15952783-3	2005	The Mms2-Ubc13 heterodimer links Ub molecules to one another through an isopeptide bond between its own C-terminus and Lys-63 on another Ub.	Lysine	119-122	ubiquitin conjugating enzyme E2 V2	Homo sapiens	4-8
23560854-2	2013	Ubiquitylation requires the co-ordinated action of three enzymes termed E1, E2 and E3, and typically results in the formation of an isopeptide bond between the C-terminal carboxy group of ubiquitin and the epsilon-amino group of a target lysine residue.	Lysine	238-244	small nucleolar RNA, H/ACA box 73A	Homo sapiens	72-85
23934123-7	2013	ChIP assays demonstrated that activation of the HGF-MET pathway resulted in increased occupancy of the MLL-ETS2 complex on MMP1 and MMP3 promoters, where MLL trimethylated histone H3 lysine 4 (H3K4), activating transcription.	Lysine	183-189	E26 avian leukemia oncogene 2, 3' domain	Mus musculus	107-111
15952783-3	2005	The Mms2-Ubc13 heterodimer links Ub molecules to one another through an isopeptide bond between its own C-terminus and Lys-63 on another Ub.	Lysine	119-122	ubiquitin conjugating enzyme E2 N	Homo sapiens	9-14
2506564-7	1989	A glucose-lysine reaction compound, 2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine was found to be a strong competitive inhibitor of aminopeptidase N (Ki = 0.2mM) in vitro.	Lysine	10-16	alanyl aminopeptidase, membrane	Rattus norvegicus	133-149
15952783-4	2005	The role of Mms2 is to orient a target-bound Ub molecule such that its Lys-63 is proximal to the C-terminus of the Ub molecule that is covalently linked to the active site of Ubc13.	Lysine	71-74	ubiquitin conjugating enzyme E2 V2	Homo sapiens	12-16
15952783-4	2005	The role of Mms2 is to orient a target-bound Ub molecule such that its Lys-63 is proximal to the C-terminus of the Ub molecule that is covalently linked to the active site of Ubc13.	Lysine	71-74	ubiquitin conjugating enzyme E2 N	Homo sapiens	175-180
15920479-4	2005	Strains lacking Sas2 histone acetylase or the histone methylases that modify lysines 4 (Set1) or 79 (Dot1) of H3 display accelerated Sir3 accumulation at HMR or its spreading away from the telomere, suggesting that these histone modifications exert distinct inhibitory effects on heterochromatin formation.	Lysine	77-84	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	88-92
2848033-0	1988	Thermodynamic stabilities of yeast iso-1-cytochromes c having amino acid substitutions for lysine 32.	Lysine	91-97	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	35-40
15941828-4	2005	Like Set1, MLL1 localizes with RNA polymerase II (Pol II) to the 5" end of actively transcribed genes, where histone H3 lysine 4 trimethylation occurs.	Lysine	120-126	lysine methyltransferase 2A	Homo sapiens	11-15
23678181-9	2013	It was found that the V protein inhibited TRAF6-mediated lysine 63 (K63)-linked polyubiquitination of IRF7, which is prerequisite for IRF7 activation.	Lysine	57-63	TNF receptor associated factor 6	Homo sapiens	42-47
3263437-0	1988	The construction and characterization of a biologically active recombinant IL-2 containing a lysine-rich C-terminal extension.	Lysine	93-99	interleukin 2	Rattus norvegicus	75-79
23752130-7	2013	We found that acetylation on histone 3 lysine 9 (acetyl-H3K9) around the MFG-E8 promoter was significantly increased with butyric acid exposure.	Lysine	39-45	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	73-79
23673667-6	2013	Mutation of each lysine residue revealed that Lys-35 is the major SUMOylation site on Maf1 and that the deSUMOylase, SENP1, is responsible for controlling Maf1K35 SUMOylation.	Lysine	46-49	MAF1 homolog, negative regulator of RNA polymerase III	Homo sapiens	86-90
23673667-8	2013	By preventing SUMOylation at Lys-35, Maf1 is impaired in its ability to both repress transcription and suppress colony growth.	Lysine	29-32	MAF1 homolog, negative regulator of RNA polymerase III	Homo sapiens	37-41
15786493-3	2005	It was first demonstrated for the yeast MLL homolog complex, Set1/COMPASS, and now for the MLL complex itself, that these complexes are histone methyltransferases capable of methylating the fourth lysine of histone H3.	Lysine	197-203	lysine methyltransferase 2A	Homo sapiens	40-43
15786493-3	2005	It was first demonstrated for the yeast MLL homolog complex, Set1/COMPASS, and now for the MLL complex itself, that these complexes are histone methyltransferases capable of methylating the fourth lysine of histone H3.	Lysine	197-203	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	61-65
15786493-3	2005	It was first demonstrated for the yeast MLL homolog complex, Set1/COMPASS, and now for the MLL complex itself, that these complexes are histone methyltransferases capable of methylating the fourth lysine of histone H3.	Lysine	197-203	lysine methyltransferase 2A	Homo sapiens	91-94
23696636-5	2013	To confirm N-terminal ubiquitination, we generated lysine-less and N-terminally blocked versions of one substrate, the polyglutamine disease protein ataxin-3, and showed that Ube2w can ubiquitinate a lysine-less, but not N-terminally blocked, ataxin-3.	Lysine	51-57	ubiquitin conjugating enzyme E2 W	Homo sapiens	175-180
3263437-1	1988	A polylysine extended gibbon IL-2 (IL-2-L) was constructed by the addition of a lysine-rich oligopeptide, Gly3-(Lys-Lys-Asp)3-Leu-Glu to the C terminus of gibbon IL-2 by using rDNA technology.	Lysine	6-12	interleukin 2	Rattus norvegicus	29-33
23696636-5	2013	To confirm N-terminal ubiquitination, we generated lysine-less and N-terminally blocked versions of one substrate, the polyglutamine disease protein ataxin-3, and showed that Ube2w can ubiquitinate a lysine-less, but not N-terminally blocked, ataxin-3.	Lysine	200-206	ubiquitin conjugating enzyme E2 W	Homo sapiens	175-180
3263437-1	1988	A polylysine extended gibbon IL-2 (IL-2-L) was constructed by the addition of a lysine-rich oligopeptide, Gly3-(Lys-Lys-Asp)3-Leu-Glu to the C terminus of gibbon IL-2 by using rDNA technology.	Lysine	6-12	interleukin 2	Rattus norvegicus	35-39
3263437-1	1988	A polylysine extended gibbon IL-2 (IL-2-L) was constructed by the addition of a lysine-rich oligopeptide, Gly3-(Lys-Lys-Asp)3-Leu-Glu to the C terminus of gibbon IL-2 by using rDNA technology.	Lysine	6-12	interleukin 2	Rattus norvegicus	35-39
15908192-7	2005	These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate.	Lysine	178-184	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	56-59
15908192-7	2005	These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate.	Lysine	178-184	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	138-141
3263437-6	1988	Thus, the addition of the lysine-rich oligopeptide facilitated the generation of an active form of biotinylated IL-2 which acts as a bridge between IL-2R-positive cells and avidin-coupled reagents and affinity supports.	Lysine	26-32	interleukin 2	Rattus norvegicus	112-116
15908192-8	2005	In addition, the non-proportional increase in cross-links (20-fold) with respect to the decrease in lysyl hydroxylation state of the triple helix (2-fold) even suggests that LH1 preferentially hydroxylates triple helical lysine residues at the cross-link positions.	Lysine	221-227	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	174-177
23445175-7	2013	Microsomal assays using a lysine residue-specific reagent show that the reverse ceramidase activity can only be blocked when the reagent has access to Ypc1p from the lumenal side.	Lysine	26-32	phytoceramidase	Saccharomyces cerevisiae S288C	151-156
15899859-0	2005	In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.	Lysine	85-91	chromobox 5	Homo sapiens	8-11
3140897-0	1988	Inactivation of yeast hexokinase by o-phthalaldehyde: evidence for the presence of a cysteine and a lysine at or near the active site.	Lysine	100-106	hexokinase	Saccharomyces cerevisiae S288C	22-32
15899859-4	2005	In vivo targeting of an enhanced green fluorescent protein-tagged HP1-lac repressor fusion to a lac operator-containing, gene-amplified chromosome region causes local condensation of the higher-order chromatin structure, recruitment of the histone methyltransferase SETDB1, and enhanced trimethylation of histone H3 lysine 9.	Lysine	316-322	chromobox 5	Homo sapiens	66-69
3140897-14	1988	Thus, it is concluded that two cysteines and lysines at or near the active site of the hexokinase were involved in reaction with o-phthalaldehyde following complete loss of the phosphotransferase activity.	Lysine	45-52	hexokinase	Saccharomyces cerevisiae S288C	87-97
15916965-5	2005	The structures and associated biochemical assays reveal the mechanism of binding, which involves an interaction between the PA26 C terminus and a conserved lysine.	Lysine	156-162	sestrin 1	Homo sapiens	124-128
3145094-7	1988	Comparison of mouse and human NF-H reveals that otherwise conserved proteins have been subjected to evolutionary mutation within their multiphosphorylation repeat domains, although the Lys-Ser-Pro motif has been conserved.	Lysine	185-188	neurofilament heavy chain	Homo sapiens	30-34
15683365-8	2005	The specific activity of the alternative mutant Trp234--&gt;Lys was lower than for the parental human GST T1-1 with many substrates, showing that a positive charge is not sufficient for increased activity.	Lysine	60-63	CD2 molecule	Homo sapiens	106-110
23647335-0	2013	Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.	Lysine	105-111	synaptotagmin 2	Homo sapiens	29-45
23616576-0	2013	Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.	Lysine	0-6	T-box transcription factor 21	Homo sapiens	114-119
23616576-4	2013	In this study, we found that T-bet underwent proteasomal degradation via ubiquitination at Lys-313.	Lysine	91-94	T-box transcription factor 21	Homo sapiens	29-34
23616576-9	2013	Collectively, these data show that Lys-313 in the T-box domain is essential for controlling T-bet protein stability via ubiquitin-dependent degradation, T-bet binding to the IFN-gamma promoter, and for the interaction with and suppression of NFAT1.	Lysine	35-38	T-box transcription factor 21	Homo sapiens	92-97
15782135-4	2005	We show here that, in contrast to other caspases such as caspase-9 and -3, caspase-8 can be sumoylated at lysine 156.	Lysine	106-112	caspase 9	Homo sapiens	57-73
23616576-9	2013	Collectively, these data show that Lys-313 in the T-box domain is essential for controlling T-bet protein stability via ubiquitin-dependent degradation, T-bet binding to the IFN-gamma promoter, and for the interaction with and suppression of NFAT1.	Lysine	35-38	T-box transcription factor 21	Homo sapiens	153-158
3217917-7	1988	These findings indicate, for the first time, that both glutamine acceptor and lysine donor activities may be localized within CNBr VIII.	Lysine	78-84	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	126-135
23616576-9	2013	Collectively, these data show that Lys-313 in the T-box domain is essential for controlling T-bet protein stability via ubiquitin-dependent degradation, T-bet binding to the IFN-gamma promoter, and for the interaction with and suppression of NFAT1.	Lysine	35-38	nuclear factor of activated T cells 2	Homo sapiens	242-247
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	lysine methyltransferase 2A	Homo sapiens	10-13
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	lysine methyltransferase 2A	Homo sapiens	21-25
15718234-0	2005	Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.	Lysine	67-73	synuclein alpha	Homo sapiens	0-15
15718234-8	2005	We determined that Parkin functions with UbcH13/Uev1a, a dimeric ubiquitin-conjugating enzyme, to assemble ubiquitin lysine 63-linked chains.	Lysine	117-123	ubiquitin conjugating enzyme E2 N	Homo sapiens	41-47
15718234-8	2005	We determined that Parkin functions with UbcH13/Uev1a, a dimeric ubiquitin-conjugating enzyme, to assemble ubiquitin lysine 63-linked chains.	Lysine	117-123	ubiquitin conjugating enzyme E2 V1	Homo sapiens	48-53
2839368-2	1988	Digestion of phosphorylated vimentin with lysine-specific endoprotease and subsequent tryptic peptide mapping indicated that a 12 kDa N-terminal fragment contained all the phosphorylation sites found in the intact molecule.	Lysine	42-48	vimentin	Homo sapiens	28-36
15718234-10	2005	alpha-Synuclein also stimulated the assembly of lysine 63-linked ubiquitin chains.	Lysine	48-54	synuclein alpha	Homo sapiens	0-15
15718234-11	2005	Because UCH-L1, a ubiquitin hydrolase, was recently reported to form lysine 63-linked conjugates, it is evident that three proteins that are genetically linked to Parkinson disease can contribute to lysine 63 multiubiquitin chain formation.	Lysine	69-75	ubiquitin C-terminal hydrolase L1	Homo sapiens	8-14
15718234-11	2005	Because UCH-L1, a ubiquitin hydrolase, was recently reported to form lysine 63-linked conjugates, it is evident that three proteins that are genetically linked to Parkinson disease can contribute to lysine 63 multiubiquitin chain formation.	Lysine	199-205	ubiquitin C-terminal hydrolase L1	Homo sapiens	8-14
15823605-9	2005	Substitution of the aspartic acid at position 61 and glutamic acid at position 63 in the SIV(cpz) ANT Vpu within with lysine residues abolished the ability of this protein to down-modulate cell surface expression of CD4.	Lysine	118-124	solute carrier family 25 member 6	Homo sapiens	98-101
23585276-8	2013	This domain contains the IGF2 gene and is marked by a histone H3 lysine 27 trimethylation block between CTCF site upstream of the IGF2 promoters and the Centrally Conserved Domain upstream of the ICR.	Lysine	65-71	insulin like growth factor 2	Homo sapiens	25-29
23585276-8	2013	This domain contains the IGF2 gene and is marked by a histone H3 lysine 27 trimethylation block between CTCF site upstream of the IGF2 promoters and the Centrally Conserved Domain upstream of the ICR.	Lysine	65-71	insulin like growth factor 2	Homo sapiens	130-134
23658530-2	2013	We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by de-methylation of histone H3 at lysine 27 by KDM6A, a histone demethylase with female-biased expression.	Lysine	110-116	lysine (K)-specific demethylase 6A	Mus musculus	123-128
3258649-10	1988	By systematically altering surface residues in the mouse IgG2b isotype, we have localized the binding site for C1q to three side chains, Glu 318, Lys 320 and Lys 322.	Lysine	146-149	complement C1q A chain	Homo sapiens	111-114
23514740-6	2013	Moreover, LAT was ubiquitinated at Lys(88) by TRAF6 via K63-linked chain.	Lysine	35-38	TNF receptor associated factor 6	Homo sapiens	46-51
23417673-3	2013	We previously demonstrated that HIC1 can be either acetylated or SUMOylated on lysine 314.	Lysine	79-85	HIC ZBTB transcriptional repressor 1	Homo sapiens	32-36
23575859-8	2013	Increased gene expression of c-Fos and Nr4a2 is correlated with decreased HDAC3 occupancy and increased histone H4 lysine 8 acetylation at their promoters.	Lysine	115-121	FBJ osteosarcoma oncogene	Mus musculus	29-34
15820677-3	2005	SUMO-conjugating enzyme is seen to be resident in plasma membrane, to assemble with K2P1, and to modify K2P1 lysine 274.	Lysine	109-115	potassium two pore domain channel subfamily K member 1	Homo sapiens	84-88
15820677-3	2005	SUMO-conjugating enzyme is seen to be resident in plasma membrane, to assemble with K2P1, and to modify K2P1 lysine 274.	Lysine	109-115	potassium two pore domain channel subfamily K member 1	Homo sapiens	104-108
15899702-3	2005	Cathepsin L, cathepsin K, plasmin, trypsin and tryptase were able to release elafin by cleaving the Lys 38 -Ala 39 peptide bond in trappin-2.	Lysine	100-103	cathepsin K	Homo sapiens	13-24
15677454-5	2005	We found that Tal1/SCL could complex with the histone H3 lysine 9 (H3K9)-specific methyltransferase Suv39H1.	Lysine	57-63	TAL bHLH transcription factor 1, erythroid differentiation factor	Homo sapiens	14-18
3128173-2	1988	Acetylation of 11 lysine residues of the reductase with acetic anhydride yielded a 20-40% decrease in the apparent Km of the reductase for cytochrome P-450b or cytochrome P-450c using either 7-ethoxycoumarin or benzphetamine as substrates.	Lysine	18-24	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-177
15767660-0	2005	Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment.	Lysine	32-38	chromobox 5	Homo sapiens	84-109
15767660-1	2005	Histone H3 lysine 9 (H3-K9) methylation has been shown to correlate with transcriptional repression and serve as a specific binding site for heterochromatin protein 1 (HP1).	Lysine	11-17	chromobox 5	Homo sapiens	141-166
15767660-1	2005	Histone H3 lysine 9 (H3-K9) methylation has been shown to correlate with transcriptional repression and serve as a specific binding site for heterochromatin protein 1 (HP1).	Lysine	11-17	chromobox 5	Homo sapiens	168-171
3394172-0	1988	[Binding of K 1-3 and K 4 fragments of plasminogen containing lysine-binding sites with fibrinogen and its fragments].	Lysine	62-68	keratin 13	Homo sapiens	12-17
23455153-4	2013	We showed that UBE2O functions as an E2-E3 hybrid to monoubiquitinate SMAD6 at lysine 174 and that the cysteine 885 residue of human UBE2O is necessary for SMAD6 monoubiquitination.	Lysine	79-85	SMAD family member 6	Homo sapiens	156-161
2820990-8	1987	The reaction rates of horse heart cytochrome c derivatives modified at single lysine amino groups with trifluoroacetyl or trifluoromethylphenylcarbamoyl were also measured.	Lysine	78-84	cytochrome c, somatic	Equus caballus	34-46
23509280-5	2013	Western blot using antibodies specific for antimethylated SUV39H1 and mass spectrometry demonstrated that SUV39H1 was specifically methylated at lysines 105 and 123 by SET7/9.	Lysine	145-152	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	168-174
23382074-5	2013	Moreover, we show that USP22 is acetylated on multiple lysine residues and that alteration of a single lysine (K129) within the ZnF-UBP domain is sufficient to alter interaction of the DUBm with the core SAGA complex.	Lysine	55-61	ubiquitin specific peptidase 22	Homo sapiens	23-28
15775977-1	2005	Trimethylation of lysine 4 of histone H3 occurs at the 5" end of active genes and is catalyzed by Set1 in Saccharomyces cerevisiae.	Lysine	18-24	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	98-102
15752042-0	2005	Effect of mono-CDNP substitution of lysine residues on the redox reaction of cytochrome c electrostatically adsorbed on a mercaptoheptanoic acid modified Au(111) surface.	Lysine	36-42	cytochrome c, somatic	Equus caballus	77-89
2823795-5	1987	Comparison of these results with spectra obtained for the n-butylamine adduct of soybean leghaemoglobin support the hypothesis that lysine is the sixth ligand in the alkaline form of horse heart cytochrome c.	Lysine	132-138	cytochrome c, somatic	Equus caballus	195-207
15752042-1	2005	The effect of charge-inverting modification of single surface lysine residue on the electron transfer (ET) reaction of horse heart cytochrome c (cyt c) is examined for 12 different types of mono-4-chloro-2,5-dinitrobenzoic acid substituted cyt c (mCDNPc) adsorbed on a Au(111) electrode modified with a self-assembled monolayer (SAM) of 7-mercapto-heptanoic acid (MHA).	Lysine	62-68	cytochrome c, somatic	Equus caballus	131-143
15752042-1	2005	The effect of charge-inverting modification of single surface lysine residue on the electron transfer (ET) reaction of horse heart cytochrome c (cyt c) is examined for 12 different types of mono-4-chloro-2,5-dinitrobenzoic acid substituted cyt c (mCDNPc) adsorbed on a Au(111) electrode modified with a self-assembled monolayer (SAM) of 7-mercapto-heptanoic acid (MHA).	Lysine	62-68	cytochrome c, somatic	Equus caballus	145-150
15591590-7	2005	Furthermore, we demonstrate that both HMGA1 isoforms are di-methylated on arginine and lysine residues.	Lysine	87-93	high mobility group AT-hook 1	Homo sapiens	38-43
23431328-4	2013	An important step in X chromosome inactivation is the recruitment of the Polycomb repressive complex PRC2 that mediates histone H3 lysine 27 methylation, a hallmark of the inactive X chromosome, and recent studies have suggested that this occurs as a consequence of PRC2 interacting directly with Xist RNA.	Lysine	131-137	X inactive specific transcript	Homo sapiens	297-301
3038891-4	1987	The deduced bovine p11 amino acid sequence is identical to the previously published partial bovine and complete porcine p11 protein sequence except for an additional COOH-terminal lysine residue.	Lysine	180-186	S100 calcium binding protein A10	Bos taurus	19-22
23453969-2	2013	Here, we show that IKKepsilon is modified and regulated by K63-linked polyubiquitination at lysine 30 and lysine 401.	Lysine	92-98	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	19-29
23453969-2	2013	Here, we show that IKKepsilon is modified and regulated by K63-linked polyubiquitination at lysine 30 and lysine 401.	Lysine	106-112	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	19-29
23453972-4	2013	An intact TBK1 dimer undergoes K63-linked polyubiquitination on lysines 30 and 401, and these modifications are required for TBK1 activity.	Lysine	64-71	TANK binding kinase 1	Homo sapiens	10-14
16833496-1	2005	We have examined the role of the catalytic lysine (Lys 249) in breaking the glycosidic bond of 8-oxoguanine in the enzyme human 8-oxoguanine DNA glycosylase.	Lysine	43-49	8-oxoguanine DNA glycosylase	Homo sapiens	128-156
2822094-8	1987	The reaction rates of horse heart cytochrome c derivatives modified at single lysine amino groups with trifluoroacetyl or trifluoromethylphenylcarbamoyl were also measured.	Lysine	78-84	cytochrome c, somatic	Equus caballus	34-46
16833496-1	2005	We have examined the role of the catalytic lysine (Lys 249) in breaking the glycosidic bond of 8-oxoguanine in the enzyme human 8-oxoguanine DNA glycosylase.	Lysine	51-54	8-oxoguanine DNA glycosylase	Homo sapiens	128-156
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	Lysine	142-144	ribosomal protein S6 kinase B1	Rattus norvegicus	64-70
23499448-4	2013	We show that the deubiquitylating enzyme UCH-L1 is a key regulator of NOXA turnover, which protects NOXA from proteasomal degradation by removing Lys(48)-linked polyubiquitin chains.	Lysine	146-149	ubiquitin C-terminal hydrolase L1	Homo sapiens	41-47
23507839-6	2013	Znf198, stabilizes the LSD1-CoREST-HDAC complex that removes, via lysine demethylase1 (LSD1), the activating trimethylation of H3 on lysine-4 (H3K4me3).	Lysine	66-72	REST corepressor 1	Homo sapiens	28-34
16040344-3	2005	The deduced Bndhn ERD10 protein contained an 8-serine residue domain and two conserved repeats of the characterized lysine-rich-K-segment (KIKEKLPG).	Lysine	116-122	dehydrin ERD10-like	Brassica napus	18-23
2822095-5	1987	In order to define the interaction domain on horse cytochrome c, the reaction rates of derivatives modified at single lysine amino groups with trifluoroacetyl or trifluoromethylphenylcarbamoyl were measured.	Lysine	118-124	cytochrome c, somatic	Equus caballus	51-63
2822095-7	1987	This result indicates that lysines surrounding the heme crevice of horse cytochrome c are involved in electrostatic interactions with carboxylate groups at the binding site on the cytochrome bc1 complex.	Lysine	27-34	cytochrome c, somatic	Equus caballus	73-85
15748426-8	2005	As(2)O(3) binds ubiquitin like SUMO-1 through the lysine 160 of PML, resulting in the degradation of PML-RAR alpha.	Lysine	50-56	PML nuclear body scaffold	Homo sapiens	64-67
2885328-4	1987	An endoprotease cleaving either the substrate Pro-Arg-Glu-Arg-Lys-Ala-Gly-Ala-Lys-Asn-Tyr-NH2, i.e. [Ala17,Tyr20]S-28-(10-20)-NH2 (peptide I), or the octacosapeptide somatostatin-28, on the NH2 side of the Arg-Lys doublet was separated from an aminopeptidase B-like activity.	Lysine	62-65	arginyl aminopeptidase	Rattus norvegicus	244-260
15748426-8	2005	As(2)O(3) binds ubiquitin like SUMO-1 through the lysine 160 of PML, resulting in the degradation of PML-RAR alpha.	Lysine	50-56	PML nuclear body scaffold	Homo sapiens	101-104
3110143-2	1987	Modification of antithrombin with limiting amounts of reagent yields an average incorporation of the phosphopyridoxyl label into 1 lysine/protein molecule (Pecon, J. M., and Blackburn, M. N. (1984) J. Biol.	Lysine	131-137	serpin family C member 1	Homo sapiens	16-28
15528187-5	2005	Lge1p is a nuclear protein that has been found to play a role in ubiquitination of histone H2B at Lys(123).	Lysine	98-101	H2B clustered histone 21	Homo sapiens	91-94
23341449-6	2013	Specifically, two basic OCAM Ig5 residues (Lys and Arg) found near asparagines equivalent to those carrying the polysialylated N-glycans in NCAM substantially decrease or eliminate polysialylation when used to replace the smaller and more neutral residues (Ser and Asn) in analogous positions in NCAM Ig5.	Lysine	43-46	neural cell adhesion molecule 1	Homo sapiens	140-144
23341449-6	2013	Specifically, two basic OCAM Ig5 residues (Lys and Arg) found near asparagines equivalent to those carrying the polysialylated N-glycans in NCAM substantially decrease or eliminate polysialylation when used to replace the smaller and more neutral residues (Ser and Asn) in analogous positions in NCAM Ig5.	Lysine	43-46	neural cell adhesion molecule 1	Homo sapiens	296-300
23406569-4	2013	Here, using NMR (15)N relaxation and hydrogen-bond scalar (15)N-(31)P J-couplings ((h3)J(NP)), we have investigated the dynamics of the ion pairs between lysine side-chain NH3(+) amino groups and DNA phosphate groups at the molecular interface of the HoxD9 homeodomain-DNA complex.	Lysine	154-160	homeobox D9	Homo sapiens	251-256
3110143-9	1987	This peptide corresponds to a tryptic fragment including residues 115-129 in the sequence of antithrombin, with the modified residue identified as Lys-125.	Lysine	147-150	serpin family C member 1	Homo sapiens	93-105
15580297-7	2005	Ubc9 and PIAS1 stimulate sumoylation in vivo of lysine 162 in the NID.	Lysine	48-54	protein inhibitor of activated STAT 1	Homo sapiens	9-14
3110143-11	1987	Identification of this critical lysine for heparin binding strongly supports previous data which indicate that the heparin-binding domain of antithrombin is located at the NH2 terminus within one of the disulfide cross-linked loops of the protein.	Lysine	32-38	serpin family C member 1	Homo sapiens	141-153
23412334-2	2013	As aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in hematopoietic cells through interactions with the histone H3 lysine 79 (H3K79) methyltransferase DOT1L.	Lysine	146-152	lysine methyltransferase 2A	Homo sapiens	40-43
2952652-7	1987	The sequence of this peptide was determined to be NH2-Met1-Tyr2-Ser3-Lys4-Gly5-Ala6-Ser7-Glu8++ +-Ile9-Ile10-Leu11-Arg12-COOH; fluorescein isothiocyanate reacts with the lysine residue.	Lysine	170-176	granzyme M	Homo sapiens	54-58
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	TNF receptor associated factor 6	Homo sapiens	15-20
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	TNF receptor associated factor 6	Homo sapiens	140-145
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	227-231
16333984-7	2005	The necessity of Ile296, Thr298, and Arg299, which are replaced by Leu, Met/Leu, and Lys, respectively, in some eukaryotic Hsp90, was dependent on the mAbs, and K41110 and K41116C could react with Hsp90s carrying these substitutions.	Lysine	85-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	123-128
16333984-7	2005	The necessity of Ile296, Thr298, and Arg299, which are replaced by Leu, Met/Leu, and Lys, respectively, in some eukaryotic Hsp90, was dependent on the mAbs, and K41110 and K41116C could react with Hsp90s carrying these substitutions.	Lysine	85-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	197-202
15339847-1	2004	The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase that functions in nucleotide excision repair of chemotherapy-induced DNA damage, the efficiency of which is predicted to be affected by a lysine to glutamine variant at codon 751.	Lysine	206-212	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-33
3654593-2	1987	The most predominant amino acid in the phospholipase A2 was cysteine followed by lysine, suggesting that it is a basic one.	Lysine	81-87	phospholipase A2 group IB	Rattus norvegicus	39-55
15339847-1	2004	The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase that functions in nucleotide excision repair of chemotherapy-induced DNA damage, the efficiency of which is predicted to be affected by a lysine to glutamine variant at codon 751.	Lysine	206-212	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	35-38
15339847-5	2004	Furthermore, homozygosity for the XPD codon 751 glutamine variant was associated with a significantly increased risk of developing AML after chemotherapy (odds ratio, 2.22 for Gln/Gln vs Lys/Lys; 95% CI, 1.04-4.74).	Lysine	187-190	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	34-37
15339847-5	2004	Furthermore, homozygosity for the XPD codon 751 glutamine variant was associated with a significantly increased risk of developing AML after chemotherapy (odds ratio, 2.22 for Gln/Gln vs Lys/Lys; 95% CI, 1.04-4.74).	Lysine	191-194	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	34-37
15459184-6	2004	The loss of antisense transcription from the Kcnq1ot1 promoter coincides with an enrichment in the levels of deacetylation and methylation at the lysine 9 residue of histone H3 and DNA methylation at the CpG residues, implying a crucial role for the NF-Y transcription factor in organizing the parent of origin-specific chromatin conformation in the Kcnq1 ICR.	Lysine	146-152	KCNQ1 overlapping transcript 1	Mus musculus	45-53
15459184-6	2004	The loss of antisense transcription from the Kcnq1ot1 promoter coincides with an enrichment in the levels of deacetylation and methylation at the lysine 9 residue of histone H3 and DNA methylation at the CpG residues, implying a crucial role for the NF-Y transcription factor in organizing the parent of origin-specific chromatin conformation in the Kcnq1 ICR.	Lysine	146-152	potassium voltage-gated channel, subfamily Q, member 1	Mus musculus	45-50
23329845-7	2013	In addition, we show that Lys-78 and Arg-79 are critical for the binding of ILKAP to importin alpha.	Lysine	26-29	ILK associated serine/threonine phosphatase	Homo sapiens	76-81
22991139-8	2013	Finally, we found that ATF3 is selectively SUMOylated at lysine residue 42 but the SUMOylation does not alter subcellular localization of ATF3.	Lysine	57-63	activating transcription factor 3	Homo sapiens	23-27
3032943-2	1987	These forms arise as the result of the presence, at a single position, of 102 additional nucleotides in the mRNA for elastin a and of 60 of these nucleotides in the mRNA for elastin b as compared to the mRNA for elastin c. As expected, most lysines occur in pairs, separated by two or three small amino acid residues.	Lysine	241-248	elastin	Bos taurus	117-124
23382189-3	2013	One member of the complex, MOF, a histone acetyltransferase, acetylates lysine 16 of histone H4 and another, MSL2, which is only expressed in males, triggers its assembly.	Lysine	72-78	male-specific lethal 2	Drosophila melanogaster	109-113
15572450-2	2004	We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the core of lysine-type PGNs from Gram-positive bacteria.	Lysine	179-185	peptidoglycan recognition protein 3	Homo sapiens	105-116
2951254-11	1987	Fluorescence resonance energy transfer between the donor 1,5-IAEDANS bound to SH1 of myosin subfragment-1 and the acceptor fluorescein-5-isothiocyanate bound to Lys-61 of actin in the rigor complex was measured.	Lysine	161-164	myosin heavy chain 14	Homo sapiens	85-91
18404400-3	2004	The residue corresponding to lysine 79 in NTPDase3 is conserved in all known cell surface membrane NTPDases (NTPDase1, 2, 3, and 8), but not in the soluble, monomeric NTPDases (NTPDase5 and 6), or in the intracellular, two transmembrane NTPDases (NTPDase4 and 7).	Lysine	29-35	ectonucleoside triphosphate diphosphohydrolase 4	Homo sapiens	247-255
18404400-4	2004	This conserved lysine is located between apyrase conserved region 1 (ACR1) and an invariant glycosylation site (N81), in a region previously hypothesized to be important for NTPDase3 oligomeric structure.	Lysine	15-21	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	174-182
15377664-0	2004	Physical association of eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly enhances its binding to eIF3.	Lysine	95-101	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	107-115
23297412-6	2013	We found that SIRT1 induced p300 down-regulation via the ubiquitin-proteasome pathway by deacetylation of lysine residues for ubiquitination.	Lysine	106-112	sirtuin 1	Mus musculus	14-19
3112244-1	1987	Two lower-molecular-weight derivatives of recombinant human interferon-gamma (rIFN-gamma) were purified concurrently from a lysozyme-EDTA extract of Escherichia coli cells by immunoaffinity chromatography using a monoclonal antibody (MAb) against a synthetic carboxy-terminal peptide (Lys-131-Gln-146).	Lysine	285-288	interferon gamma	Rattus norvegicus	78-88
23258539-6	2013	Lentiviral TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated Lys-48 and Lys-63-linked ubiquitin to TDP-43 and led to cytosolic co-localization of Parkin with ubiquitinated TDP-43.	Lysine	111-114	TAR DNA binding protein	Rattus norvegicus	149-155
23258539-6	2013	Lentiviral TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated Lys-48 and Lys-63-linked ubiquitin to TDP-43 and led to cytosolic co-localization of Parkin with ubiquitinated TDP-43.	Lysine	111-114	TAR DNA binding protein	Rattus norvegicus	149-155
23258539-6	2013	Lentiviral TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated Lys-48 and Lys-63-linked ubiquitin to TDP-43 and led to cytosolic co-localization of Parkin with ubiquitinated TDP-43.	Lysine	122-125	TAR DNA binding protein	Rattus norvegicus	149-155
23258539-6	2013	Lentiviral TDP-43 increased the levels of nuclear and cytosolic protein, whereas Parkin co-expression mediated Lys-48 and Lys-63-linked ubiquitin to TDP-43 and led to cytosolic co-localization of Parkin with ubiquitinated TDP-43.	Lysine	122-125	TAR DNA binding protein	Rattus norvegicus	149-155
15525938-3	2004	Here we report a novel mechanism of p53 regulation through lysine methylation by Set9 methyltransferase.	Lysine	59-65	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	81-85
3453895-6	1987	Cleavage at an internal pair of lysine residues yields gastrin 17.	Lysine	32-38	gastrin	Homo sapiens	55-62
15280381-1	2004	Set1p methylates lysine 4 of histone H3 and can activate transcription by recruiting the chromatin-remodeling factor Isw1p.	Lysine	17-23	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	0-5
15465037-4	2004	In combination with the ubiquitin conjugating enzyme complex Ubc13/Uev1A, TRAF6 could catalyze the formation on itself of unique Lys-63 linked polyubiquitin chain that positively regulated NF-kappaB signaling pathway.	Lysine	129-132	ubiquitin conjugating enzyme E2 N	Homo sapiens	61-66
15465037-4	2004	In combination with the ubiquitin conjugating enzyme complex Ubc13/Uev1A, TRAF6 could catalyze the formation on itself of unique Lys-63 linked polyubiquitin chain that positively regulated NF-kappaB signaling pathway.	Lysine	129-132	ubiquitin conjugating enzyme E2 V1	Homo sapiens	67-72
15465037-4	2004	In combination with the ubiquitin conjugating enzyme complex Ubc13/Uev1A, TRAF6 could catalyze the formation on itself of unique Lys-63 linked polyubiquitin chain that positively regulated NF-kappaB signaling pathway.	Lysine	129-132	TNF receptor associated factor 6	Homo sapiens	74-79
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Lysine	124-127	Serpin 88Ea	Drosophila melanogaster	4-10
23273980-4	2013	Glucose-dependent beta-catenin nuclear retention requires lysine 354 and is mediated by alteration of the balance between p300 and sirtuins that trigger beta-catenin acetylation.	Lysine	58-64	catenin beta 1	Homo sapiens	18-30
23273982-3	2013	Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3.	Lysine	31-37	PHD finger protein 1	Mus musculus	164-168
23273982-3	2013	Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3.	Lysine	31-37	PHD finger protein 1	Mus musculus	169-173
24900672-2	2013	MLL complexes, the trithorax-like family of SET1 methyltransferases, catalyze trimethylation of lysine 4 on histone 3, and they have been widely implicated in various cancers.	Lysine	96-102	lysine methyltransferase 2A	Homo sapiens	0-3
15491612-3	2004	The crystal structure of aldolase antibody 93F3 Fab" at 2.5A resolution revealed a combining site with two lysine residues, including LysL89 that reacts to form the covalent enamine intermediate.	Lysine	107-113	FA complementation group B	Homo sapiens	48-51
15494368-5	2004	Mutant peptide derivatives that have lost a cluster of lysine in the vicinity of the transmembrane domain had reduced binding activity to Ret2p and the GMT with this sequence was delivered to the vacuole.	Lysine	55-61	coatomer subunit delta	Saccharomyces cerevisiae S288C	138-143
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Lysine	285-288	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	109-114
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	199-202	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	AGBL carboxypeptidase 2	Homo sapiens	169-173
3030433-4	1987	By comparison with the shifts reported for lysine-13-modified cytochrome c we conclude that the results reported here support the Poulos-Kraut proposed structure for the molecular redox complex between cytochrome-c peroxidase and cytochrome c.	Lysine	43-49	cytochrome c, somatic	Equus caballus	62-74
15280358-9	2004	ZNF76 is sumoylated by PIAS1 at lysine 411, which is in the minimal TBP-interacting region.	Lysine	32-38	protein inhibitor of activated STAT 1	Homo sapiens	23-28
23035012-7	2013	Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).	Lysine	111-114	transmembrane immune signaling adaptor TYROBP	Homo sapiens	42-75
23035012-7	2013	Siglec-15 associates with adaptor protein DNAX activation protein of 12 kDa (DAP12) at the binding determinant Lys(274) in the transmembrane domain and transduces a signal to spleen tyrosine kinase (Syk).	Lysine	111-114	transmembrane immune signaling adaptor TYROBP	Homo sapiens	77-82
15273251-5	2004	Acetylation of NF-E4 is restricted to a single residue (Lys(43)) in the amino-terminal domain of the protein and results in two important functional consequences.	Lysine	56-59	nuclear factor, erythroid 4	Homo sapiens	15-20
3030433-4	1987	By comparison with the shifts reported for lysine-13-modified cytochrome c we conclude that the results reported here support the Poulos-Kraut proposed structure for the molecular redox complex between cytochrome-c peroxidase and cytochrome c.	Lysine	43-49	cytochrome c, somatic	Equus caballus	230-242
15273251-8	2004	Acetylation of Lys(43) also reduces the interaction between NF-E4 and HDAC1, potentially maximizing the activating ability of the factor at the gamma-promoter.	Lysine	15-18	nuclear factor, erythroid 4	Homo sapiens	60-65
3030433-5	1987	These results indicate that the principal site of interaction with cytochrome-c peroxidase is the exposed heme edge of horse cytochrome c, in proximity to lysine-13 and the heme pyrrole II.	Lysine	155-161	cytochrome c, somatic	Equus caballus	125-137
22899583-8	2013	In addition, suppressive trimethylation of histone H3 lysine 27 of important T-cell transcription factor genes (GATA3, LEF1, TCF1) was present in anaplastic large cell lymphoma cells, which is in line with their absence in primary tumor specimens as demonstrated by immunohistochemistry.	Lysine	54-60	transcription factor 7	Homo sapiens	125-129
3028257-0	1987	The molecular dynamics of actin measured by a spin probe attached to lysine.	Lysine	69-75	actin	Oryctolagus cuniculus	26-31
23161884-7	2013	SIRT1 can deacetylate NF-kappaB at lysine 30, as well as histones adjacent to the transcription factor AP-1, NF-kappaB, and Pea3 binding sites of the MMP9 promoter, thereby suppressing MMP9 transcription, hence fixing MMP9 in the OFF mode.	Lysine	35-41	sirtuin 1	Mus musculus	0-5
15368356-7	2004	In addition, immunocytochemical analysis was done with an antibody to heterochromatin protein 1alpha (HP1alpha), whose preferential binding to heterochromatin has been linked to trimethylation of H3 at lysine 9.	Lysine	202-208	chromobox 5	Homo sapiens	70-100
15368356-7	2004	In addition, immunocytochemical analysis was done with an antibody to heterochromatin protein 1alpha (HP1alpha), whose preferential binding to heterochromatin has been linked to trimethylation of H3 at lysine 9.	Lysine	202-208	chromobox 5	Homo sapiens	102-110
3028257-2	1987	Tryptic digestion of the labeled actin followed by ultrafiltration and ion-exchange column chromatography indicated that the label was attached to residue Lys-61.	Lysine	155-158	actin	Oryctolagus cuniculus	33-38
3024978-0	1986	The transmembrane arrangement of the ADP/ATP carrier as elucidated by the lysine reagent pyridoxal 5-phosphate.	Lysine	74-80	WD and tetratricopeptide repeats 1	Homo sapiens	37-52
15325847-4	2004	In this study, we observed that the stimulation of FPRL1 by Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) caused serine phosphorylation but not tyrosine phosphorylation of STAT3 in a pertussis toxin-sensitive manner.	Lysine	64-67	formyl peptide receptor 2	Homo sapiens	51-56
3024978-1	1986	The lysine reagent pyridoxal 5-phosphate was applied to the ADP/ATP carrier (AAC) in order to elucidate topological and functional properties of the numerous lysines within the primary structure.	Lysine	4-10	WD and tetratricopeptide repeats 1	Homo sapiens	60-75
15350139-9	2004	In BIAcore analysis, IGFBP-2 and IGFBP-3 bound only to the N(epsilon)(Lys65/68b)-IGF-1-coated flowcell of a biosensor chip, confirming the inaccessibility of Gly 1 and Lys 27 when IGF-1 is bound to IGFBP-2 and IGFBP-3.	Lysine	70-73	insulin like growth factor binding protein 3	Homo sapiens	33-40
23811564-1	2013	In this study, the pharmacokinetic and pharmacodynamic properties of Lys(35), Met(N-terminal), and Lys(17)-mono-PEGylated recombinant human granulocyte colony stimulating factor (rhG-CSF) positional isomers were evaluated in rats.	Lysine	69-72	colony stimulating factor 3	Homo sapiens	140-177
2945819-4	1986	We showed that rabbit skeletal thin filaments reconstituted with actin modified at Lys-237 activate heavy meromyosin X Mg2+-ATPase activity independently of the Ca2+ ion concentration.	Lysine	83-86	actin	Oryctolagus cuniculus	65-70
23811564-1	2013	In this study, the pharmacokinetic and pharmacodynamic properties of Lys(35), Met(N-terminal), and Lys(17)-mono-PEGylated recombinant human granulocyte colony stimulating factor (rhG-CSF) positional isomers were evaluated in rats.	Lysine	99-102	colony stimulating factor 3	Homo sapiens	140-177
23906220-9	2013	Optimisation of the NN models developed for response to protein and lysine showed that diets containing 220.7 (g/kg of diet) protein and 12.85 (g/kg of diet) lysine maximise ADG, whereas maximum FE is achieved with diets containing 241.3 and 13.12 (g/kg) protein and lysine, respectively.	Lysine	158-164	ADG	Gallus gallus	174-177
23906220-9	2013	Optimisation of the NN models developed for response to protein and lysine showed that diets containing 220.7 (g/kg of diet) protein and 12.85 (g/kg of diet) lysine maximise ADG, whereas maximum FE is achieved with diets containing 241.3 and 13.12 (g/kg) protein and lysine, respectively.	Lysine	158-164	ADG	Gallus gallus	174-177
15212764-7	2004	By analysis of point mutants, we found that lysines 15 and 16 had a greater contribution to productive interaction between Arf1, ASAP1 and AGAP1 than between Arf1 and Arf GAP1.	Lysine	44-51	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	Homo sapiens	139-144
2945819-15	1986	Our results indicate that is is possible to produce an active state(s) of the myofibrils in the absence and presence of Ca2+ by specific alteration of the actin X Tm interaction following modification of myofibrillar actin most likely at Lys-237.	Lysine	238-241	actin	Oryctolagus cuniculus	155-160
15224381-4	2004	The common structural feature of U-II peptides from different species is the C-terminal portion, characterized by the disulfide bridged cyclic hexapeptide Cys-Phe-Trp-Lys-Tyr-Cys.	Lysine	167-170	urotensin 2	Homo sapiens	33-37
2945819-15	1986	Our results indicate that is is possible to produce an active state(s) of the myofibrils in the absence and presence of Ca2+ by specific alteration of the actin X Tm interaction following modification of myofibrillar actin most likely at Lys-237.	Lysine	238-241	actin	Oryctolagus cuniculus	217-222
3026438-2	1986	These rate constants were also measured with eight different singly substituted 4-carboxy-2,6-dinitrophenyl (CDNP) horse cytochrome c derivatives, modified at lysine-7, -13, -25, -27, -60, -72, -86, or -87 and with the trinitrophenyl (TNP) derivative modified at lysine-13.	Lysine	159-165	cytochrome c, somatic	Equus caballus	121-133
15351027-1	2004	Glutaric aciduria type 1 is an inborn error of lysine, hydroxylysine, and tryptophan metabolism caused by deficiency of glutaryl-coenzyme A dehydrogenase.	Lysine	47-53	glutaryl-CoA dehydrogenase	Homo sapiens	120-153
24140951-6	2013	The epsilon-amino group of Lys 305 of MAO A is proposed as possible target of the ITC group of the inhibitor.	Lysine	27-30	monoamine oxidase A	Homo sapiens	38-43
3028371-4	1986	161, 12-25], in which the break in continuity is between residues arginine-38 and lysine-39, the new analogue has a nearly normal redox potential, and can more fully restore succinate oxidation to mitochondria depleted of cytochrome c.	Lysine	82-88	cytochrome c, somatic	Equus caballus	222-234
23048139-2	2013	In liver, AASS is restricted to the mitochondrial matrix and lysine is presumptively transported through the plasma membrane by a cationic AA transporter (CAT1/2) and through the inner mitochondrial membrane by 1 or both mitochondrial ornithine transporters (ORC-1/ORC-2).	Lysine	61-67	origin recognition complex subunit 1	Sus scrofa	259-264
23516328-6	2013	Recent findings reveal that Eco1-mediated acetylation of different lysine residues in Smc3 during S phase promote either cohesion or condensation.	Lysine	67-73	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	28-32
15327770-2	2004	TAK1 is in turn activated by TRAF6, a RING domain ubiquitin ligase that facilitates the synthesis of lysine 63-linked polyubiquitin chains.	Lysine	101-107	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
15327770-2	2004	TAK1 is in turn activated by TRAF6, a RING domain ubiquitin ligase that facilitates the synthesis of lysine 63-linked polyubiquitin chains.	Lysine	101-107	TNF receptor associated factor 6	Homo sapiens	29-34
3790514-7	1986	Since EDC cross-links Lys residue with Asp or Glu residue only when they are in direct contact, the result indicates that some of the N-terminal residues 1-12 and the C-terminal residues 357-375 of actin participate in binding depactin.	Lysine	22-25	actin	Oryctolagus cuniculus	198-203
15302856-4	2004	Furthermore, in contrast to previous reports, we find that the checkpoint requires ubiquitylation but not proteasome activity, which is in agreement with the recent demonstration that Chfr conjugates ubiquitin through lysine 63 and not lysine 48.	Lysine	218-224	checkpoint with forkhead and ring finger domains	Homo sapiens	184-188
15302922-5	2004	Comparing Spalax with human and mouse p53 revealed an arginine (R) to lysine (K) substitution in Spalax (Arg-174 in human) in the DNA-binding domain, identical to known tumor associated mutations.	Lysine	70-76	transformation related protein 53, pseudogene	Mus musculus	38-41
23797602-5	2013	This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.	Lysine	77-83	protein phosphatase 2 phosphatase activator	Homo sapiens	130-134
3091607-2	1986	The fraction of eIF-4D that contains the post-translational modification of lysine converted to hypusine is not regulated with respect to translation rate in HeLa cells.	Lysine	76-82	eukaryotic translation initiation factor 5A	Homo sapiens	16-22
23064431-7	2013	Bidimensional NMR experiments indicate that a specific site at the N-terminal alpha-syn (Gly31/Lys32) is involved in the interaction with vitamins K, which is corroborated by previous studies suggesting that Lys is a key residue in the interaction with quinones.	Lysine	95-98	synuclein alpha	Homo sapiens	78-87
3735252-6	1986	Co-incubation with human serum albumin or poly-L-lysine but not lysine protected human and hamster LDH-X from gossypol.	Lysine	42-55	lactate dehydrogenase C	Homo sapiens	99-104
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	TANK binding kinase 1	Homo sapiens	310-314
23907581-4	2013	Here we report that BRAF is modified by Lys63-linked polyubiquitination at lysine 578 within its kinase domain once it is activated by gain of constitutively active mutation or epidermal growth factor (EGF) stimulation.	Lysine	75-81	epidermal growth factor	Homo sapiens	177-200
23907581-4	2013	Here we report that BRAF is modified by Lys63-linked polyubiquitination at lysine 578 within its kinase domain once it is activated by gain of constitutively active mutation or epidermal growth factor (EGF) stimulation.	Lysine	75-81	epidermal growth factor	Homo sapiens	202-205
23249737-1	2012	Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation.	Lysine	107-110	growth factor, augmenter of liver regeneration	Homo sapiens	53-56
15294972-6	2004	The short cytoplasmic tail of SIRPgamma does not contain any known signaling motifs, nor does it contain a characteristic lysine, as with SIRPbeta, that is required for DAP12 interaction.	Lysine	122-128	signal regulatory protein gamma	Homo sapiens	30-39
15151997-3	2004	The stabilization of helix 12 by a contact between its C terminus and the lysine of helix 4 has the same impact in human and mouse CARs.	Lysine	74-80	cysteinyl-tRNA synthetase	Mus musculus	131-135
15280549-1	2004	An E2 ubiquitin-conjugating enzyme, Rad6, working with an E3 ubiquitin ligase Bre1, catalyzes monoubiquitylation of histone H2B on a C-terminal lysine residue.	Lysine	144-150	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	36-40
23259061-4	2012	Here we demonstrate that Ngn3 protein stability is regulated by the ubiquitin proteasome system and that Ngn3 can be ubiquitylated on lysines, the N-terminus and, highly unusually, on non-canonical residues including cysteines and serines/threonines.	Lysine	134-141	neurogenin 3	Homo sapiens	105-109
3735252-6	1986	Co-incubation with human serum albumin or poly-L-lysine but not lysine protected human and hamster LDH-X from gossypol.	Lysine	49-55	lactate dehydrogenase C	Homo sapiens	99-104
3087015-1	1986	Using affinity chromatography on lysine Sepharose 4B, a fast-acting tissue plasminogen activator inhibitor (t-PAI) was partially purified from t-PAI-rich plasma from patients with recurrent DVT.	Lysine	33-39	serpin family B member 2	Homo sapiens	110-113
15070833-6	2004	The N-terminal sequence analysis of the fragments revealed that the enzymes cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1.	Lysine	99-102	insulin like growth factor binding protein 1	Homo sapiens	83-90
15070833-6	2004	The N-terminal sequence analysis of the fragments revealed that the enzymes cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1.	Lysine	99-102	insulin like growth factor binding protein 1	Homo sapiens	164-171
15070833-6	2004	The N-terminal sequence analysis of the fragments revealed that the enzymes cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1.	Lysine	103-106	insulin like growth factor binding protein 1	Homo sapiens	83-90
15070833-6	2004	The N-terminal sequence analysis of the fragments revealed that the enzymes cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1.	Lysine	103-106	insulin like growth factor binding protein 1	Homo sapiens	164-171
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	Lysine	27-35	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
3007477-1	1986	The chymotryptic fragment of bacteriorhodopsin, C-2 (residues 1-71), has been acetylated completely at its three lysines (residues 30, 40, and 41) by treatment with acetic anhydride.	Lysine	113-120	complement C2	Homo sapiens	48-51
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
22802127-5	2012	E(2) induced epigenetic modifications at the faah proximal promoter compatible with transcriptional activation by remarkably decreasing methylation of both DNA at CpG site and histone H3 at lysine 9.	Lysine	190-196	fatty acid amide hydrolase	Mus musculus	45-49
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Lysine	118-121	Furin 1	Drosophila melanogaster	17-22
2421435-2	1986	Lysine-binding sites of Lys-plasminogen, heavy chain and fragment K1-3 interact with the guanidyl-carboxyl pair on homoarginine-agarose.	Lysine	0-6	keratin 13	Homo sapiens	66-70
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	59-62	toll like receptor 4	Homo sapiens	215-219
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	59-62	toll like receptor 4	Homo sapiens	301-305
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	215-219
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	301-305
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	215-219
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	301-305
23078624-0	2012	Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24.	Lysine	17-23	interleukin 24	Homo sapiens	69-74
23078624-0	2012	Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24.	Lysine	17-23	interleukin 24	Homo sapiens	75-80
23078624-4	2012	MDA-7/IL-24 contains 10 lysine sites: K63, K69, K78, K119, K123, K136, K179, K189, K203, and K206.	Lysine	24-30	interleukin 24	Homo sapiens	0-5
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	215-219
2421435-2	1986	Lysine-binding sites of Lys-plasminogen, heavy chain and fragment K1-3 interact with the guanidyl-carboxyl pair on homoarginine-agarose.	Lysine	0-3	keratin 13	Homo sapiens	66-70
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	toll like receptor 4	Homo sapiens	301-305
3002455-7	1986	Neither of these species were formed in the presence of a cytochrome c derivative in which all of the lysine amino groups had been dimethylated, demonstrating that EDC had cross-linked lysine amino groups on native cytochrome c to carboxyl groups on the heme and flavin peptides.	Lysine	185-191	cytochrome c, somatic	Equus caballus	215-227
23071112-8	2012	Lysine at position 296 of Galpha(i2) was identified as the critical determinant of Nef-induced degradation.	Lysine	0-6	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	26-35
23157318-6	2012	Thirteen human proteins, including ERCC2 (also known as XPD) and NBR1, gained human-specific ubiquitylated lysines after the human-chimpanzee divergence.	Lysine	107-114	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	35-40
23157318-6	2012	Thirteen human proteins, including ERCC2 (also known as XPD) and NBR1, gained human-specific ubiquitylated lysines after the human-chimpanzee divergence.	Lysine	107-114	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	56-59
3001744-1	1985	An aortic phosphatase which dephosphorylates several proteins including phosphorylase a and the 20-kDa myosin light chains is subject to modulation in vitro by polycationic effectors such as lysine-rich histone-H1 and polylysine.	Lysine	191-197	myosin heavy chain 14	Homo sapiens	103-109
3934525-5	1985	From the results it was concluded that the basic beta 2m form has lysine and the acidic beta 2m form has asparagine as their respective C-terminal amino acids.	Lysine	66-72	beta-2-microglobulin	Cavia porcellus	49-56
23157318-7	2012	ERCC2 has a Lys/Gln polymorphism, the derived (major) allele of which confers enhanced DNA repair capacity and reduced cancer risk compared with the ancestral (minor) allele.	Lysine	12-15	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-5
22683090-8	2012	Furthermore, we report that adolescent THC exposure mediates Penk upregulation through reduction of histone H3 lysine 9 (H3K9) methylation in the NAcsh, thereby disrupting the normal developmental pattern of H3K9 methylation.	Lysine	111-117	proenkephalin	Rattus norvegicus	61-65
4016099-11	1985	Cathepsin G hydrolyzed peptides containing model desmosine residues and prefers the hydrophobic picolinoyllysine derivative over lysine by substantial margins at both the S4 and S2 subsites but will not tolerate it at S3.	Lysine	106-112	cathepsin G	Homo sapiens	0-11
23046516-5	2012	In the absence of Asxl2, there is a significant reduction in trimethylation of histone H3 lysine 27 (H3K27), a histone mark associated with lineage-specific silencing of developmental genes.	Lysine	90-96	ASXL transcriptional regulator 2	Homo sapiens	18-23
4096891-7	1985	These data, and the other results reported in this paper, led to the conclusion that the superreactivity at neutral pH of cysteine residues at positions 31 and 32 of bovine seminal ribonuclease is primarily dependent on the nearby presence of positively charged groups, particularly the epsilon-NH2 of lysine-34, and is influenced by the adjacency of the two thiols and by the protein tertiary structure.	Lysine	302-308	seminal ribonuclease	Bos taurus	173-193
23041319-5	2012	S. cerevisiae Hsp90 is acetylated on lysine 27 and 270, and key KDACs for drug resistance are Hda1 and Rpd3.	Lysine	37-43	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	14-19
2417406-1	1985	Intraperitoneal injection of lysine (400 mg/100 g body weight) in rats caused necrosis of pancreatic acinar cells with fat necrosis and a significant increase in serum amylase and lipase.	Lysine	29-35	lipase G, endothelial type	Rattus norvegicus	180-186
23043241-2	2012	We demonstrate that these chemical cross-linkers covalently cross-link the catalytic Cys residue of the yeast HECT E3 ubiquitin ligase Rsp5 with the Lys of the ubiquitination site in the model substrate Sic60-GFP.	Lysine	149-152	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	135-139
22921934-2	2012	Here, we provide evidence for the role of trimethylated histone H4 lysine 20 (H4K20me3) as a repression checkpoint that restricts expression of toll-like receptor 4 (TLR4) target genes in macrophages.	Lysine	67-73	toll like receptor 4	Homo sapiens	144-164
6510180-3	1984	The intraindividual fluctuation of lys-GSP in normoglycemic subjects is very small, resulting in an interindividual range of 3.0 +/- 0.3 lysine-bound glucose/mg protein (means +/- SD, N = 52).	Lysine	137-143	GSM1	Homo sapiens	39-42
22921934-2	2012	Here, we provide evidence for the role of trimethylated histone H4 lysine 20 (H4K20me3) as a repression checkpoint that restricts expression of toll-like receptor 4 (TLR4) target genes in macrophages.	Lysine	67-73	toll like receptor 4	Homo sapiens	166-170
22908223-5	2012	Interestingly, as the RLR pathway was activated, TSPAN6 underwent Lys-63-linked ubiquitination, which promoted its association with MAVS.	Lysine	66-69	tetraspanin 6	Homo sapiens	49-55
22908223-5	2012	Interestingly, as the RLR pathway was activated, TSPAN6 underwent Lys-63-linked ubiquitination, which promoted its association with MAVS.	Lysine	66-69	mitochondrial antiviral signaling protein	Homo sapiens	132-136
6510180-8	1984	The utility of lys-GSP for diagnosis of diabetes is compared with the results of 60 oral glucose tolerance tests.	Lysine	15-18	GSM1	Homo sapiens	19-22
6510180-9	1984	Two patients suffering from insulinoma displayed decreased lys-GSP values.	Lysine	59-62	GSM1	Homo sapiens	63-66
22909820-4	2012	This occurs both through antagonism of RNF8/RNF168-mediated lysine 63-linked poly-Ub and through the promotion of JMJD2A retention on chromatin.	Lysine	60-66	ring finger protein 8	Homo sapiens	39-43
6510180-10	1984	From these results it appears that determination of lys-GSP represents a more sensitive parameter for long-term control than HbA1a-c and is suitable for monitoring even small fluctuations of blood glucose.	Lysine	52-55	GSM1	Homo sapiens	56-59
6441113-2	1984	A detailed analysis of H1 and Hp structure was carried out by means of N-bromosuccinimide, chymotrypsin and pepsin cleavage followed by determination of the lysine residue number, positive charge and molecular length of obtained fragments by the method of incomplete succinylation.	Lysine	157-163	H1.5 linker histone, cluster member	Homo sapiens	23-32
22705350-0	2012	Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.	Lysine	0-6	catenin beta 1	Homo sapiens	59-71
22705350-6	2012	Lysine to arginine mutations within repeats 5-7 identified K394 as the major Rad6B ubiquitination site in vitro and in vivo, and confirmed by Rad6B ubiquitination of a beta-catenin peptide encompassing K394.	Lysine	0-6	catenin beta 1	Homo sapiens	168-180
6205792-8	1984	Although the enzyme associated with alpha 2M in the plasma from RA patients appeared to be similar to trypsin, the differences in optimal pH, cation concentration, degradation of Lys-containing substrates, and biological activity suggest otherwise.	Lysine	179-182	alpha-2-macroglobulin	Homo sapiens	36-44
23054437-9	2012	Lysine (Lys), methionine (Met), sodium acetate, beta-sodium hydroxybutyrate, and glucose all had more positive effects on the lactation function of DCMECs after pcDNA3.1+-stat5a-alphaS1 transfection.	Lysine	0-6	signal transducer and activator of transcription 5A	Bos taurus	171-177
23054437-9	2012	Lysine (Lys), methionine (Met), sodium acetate, beta-sodium hydroxybutyrate, and glucose all had more positive effects on the lactation function of DCMECs after pcDNA3.1+-stat5a-alphaS1 transfection.	Lysine	0-3	signal transducer and activator of transcription 5A	Bos taurus	171-177
6326144-3	1984	A carboxypeptidase B activity that cleaved the COOH-terminal -Lys-Lys-Arg residues from the adrenocorticotropin fragment ACTH-(1-17) (a potential hormone product liberated from pro-opiocortin by a trypsin-like enzyme) was detected in anterior and intermediate lobe granules.	Lysine	62-65	carboxypeptidase B1	Rattus norvegicus	2-20
22942423-3	2012	We show that, in resting macrophages, some IRF8 is conjugated to small ubiquitin-like modifiers (SUMO) 2/3 through the lysine residue 310.	Lysine	119-125	interferon regulatory factor 8	Homo sapiens	43-47
6423643-2	1984	A single cellular protein of Mr approximately 18,000 and pI near 5.1, recently identified as eukaryotic translation initiation factor eIF-4D, contains the unusual amino acid hypusine [N epsilon-(4-amino--2-hydroxybutyl)lysine] formed post-translationally from lysine with a structural contribution from the polyamine spermidine.	Lysine	219-225	eukaryotic translation initiation factor 5A	Homo sapiens	134-140
22815475-1	2012	Binding of heterochromatin protein 1 (HP1) to the histone H3 lysine 9 trimethylation (H3K9me3) mark is a hallmark of establishment and maintenance of heterochromatin.	Lysine	61-67	chromobox 5	Homo sapiens	38-41
6329161-1	1984	Preparations of horse heart cytochrome c have been obtained immobilized on Sepharose derivatives via lysine epsilon-amino groups, carboxyl groups of aspartic and glutamic acid residues, methionine and histidine residues as well as imidazole groups additionally introduced by means of modification of free carboxyl groups by histamine.	Lysine	101-107	cytochrome c, somatic	Equus caballus	28-40
6329161-2	1984	Dissociation constants have been determined for complexes of adrenodoxin, hepatoredoxin , cytochrome b5 heme-containing tryptic fragment and myoglobin with cytochrome c preparations immobilized via lysine residues (cytochrome c-Sepharose I) or additional imidazole groups (cytochrome c-Sepharose II).	Lysine	198-204	cytochrome c, somatic	Equus caballus	156-168
6526653-0	1984	Hemoglobin Shelby [beta 131(H9) Gln----Lys] a correction to the structure of hemoglobin Deaconess and hemoglobin Leslie.	Lysine	39-42	ras homolog family member C	Homo sapiens	24-30
22841713-4	2012	We demonstrate that CypM has low substrate selectivity and methylates a variety of oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine.	Lysine	176-182	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	20-24
6547165-1	1984	The immunomodulatory potential of poly-(Lys-[Leu-poly-DL-Ala]) (LAK) (Lys:Ala:Leu = 1:3:0.7) as the first prototype of a series of new branched polypeptides was studied.	Lysine	40-43	alpha-kinase 1	Mus musculus	64-67
22455726-3	2012	Recently, it has been reported that PRMT6-mediated di-methylation of histone H3 at arginine 2 (H3R2me2) can antagonize tri-methylation of histone H3 at lysine 4 (H3K4me3), which marks active genes.	Lysine	152-158	protein arginine N-methyltransferase 6	Mus musculus	36-41
22723015-10	2012	Alterations in the methylation of lysines 4 and 27 of histone H3 were detected in the promoter region of PAX6 and OCT4.	Lysine	34-41	POU class 5 homeobox 1	Homo sapiens	114-118
6352261-6	1983	Several substitutions relative to bovine insulin occur in the proposed receptor binding region (A5Gln leads to His, B21Glu leads to Pro, B22Arg leads to Lys, B25Phe leads to Tyr).	Lysine	153-156	insulin	Bos taurus	41-48
22921202-3	2012	Here we show that lack of the histone acetyltransferase MOZ (MYST3/KAT6A) phenocopies DiGeorge syndrome, and the MOZ complex occupies the Tbx1 locus, promoting its expression and histone 3 lysine 9 acetylation.	Lysine	189-195	K(lysine) acetyltransferase 6A	Mus musculus	113-116
22921202-3	2012	Here we show that lack of the histone acetyltransferase MOZ (MYST3/KAT6A) phenocopies DiGeorge syndrome, and the MOZ complex occupies the Tbx1 locus, promoting its expression and histone 3 lysine 9 acetylation.	Lysine	189-195	T-box 1	Mus musculus	138-142
6639061-11	1983	It is reported that in rabbit tissues thymosin beta 10 is also replaced by a variant, designated thymosin beta arg10, that contains an additional amino acid, arginine, inserted following lysine-38.	Lysine	187-193	thymosin beta-10	Oryctolagus cuniculus	38-54
22231382-2	2012	GA-1 is known as an autosomal recessively inherited disease due to defects in the gene coding for glutaryl-CoA dehydrogenase (GCDH), a mitochondrial enzyme involved in the catabolism of the amino acids hydroxylysine, lysine and tryptophan.	Lysine	209-215	glutaryl-CoA dehydrogenase	Homo sapiens	98-124
22231382-2	2012	GA-1 is known as an autosomal recessively inherited disease due to defects in the gene coding for glutaryl-CoA dehydrogenase (GCDH), a mitochondrial enzyme involved in the catabolism of the amino acids hydroxylysine, lysine and tryptophan.	Lysine	209-215	glutaryl-CoA dehydrogenase	Homo sapiens	126-130
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Lysine	164-167	cytochrome c, somatic	Equus caballus	98-110
22079207-7	2012	Modifications of chromatin structure, including acetylated histone H3, acetylated histone H4 and di-methylated histone H3 at lysine 4, were detected at a significantly increased level at the GLUT4 promoter region in female pup muscle following a maternal LP diet.	Lysine	125-131	solute carrier family 2 member 4	Rattus norvegicus	191-196
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Lysine	164-167	cytochrome c, somatic	Equus caballus	191-203
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Lysine	175-178	cytochrome c, somatic	Equus caballus	98-110
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Lysine	175-178	cytochrome c, somatic	Equus caballus	191-203
6638506-6	1983	The N-terminal-region amino acid sequence of the purified BAL was determined as follows: Ala-Lys-Leu-Gly-Ala-Val-Tyr-Thr-Glu-Gly-Lys-Phe-Val-Glu-Gly-Val-Asn-Lys-Lys-Leu-Gly-Leu-.	Lysine	93-96	carboxyl ester lipase	Homo sapiens	58-61
22878891-7	2012	Here, we report that histone H3 acetylation (H3Ac) and H3 lysine 4 tri-methylation (H3K4me3) levels at LHY, CCA1, and TOC1 are positively correlated with the rhythmic transcript levels of these genes, whereas H3K36me2 level shows a negative correlation.	Lysine	58-64	CCT motif -containing response regulator protein	Arabidopsis thaliana	118-122
6311171-0	1983	Ionization of tyrosine and lysine residues in native and modified horse cytochrome c.	Lysine	27-33	cytochrome c, somatic	Equus caballus	72-84
22801502-3	2012	Here we show in mice and humans that the histone H3 methylated Lys 27 (H3K27) demethylase Utx (also known as Kdm6a) regulates the efficient induction, rather than maintenance, of pluripotency.	Lysine	63-66	lysine (K)-specific demethylase 6A	Mus musculus	90-93
6311171-4	1983	spectroscopy of the lysine-modified proteins N epsilon-acetimidyl-, N epsilon-amidino-, N epsilon-trifluoroacetyl- and N epsilon-maleyl-cytochrome c have shown that, although the lysine modifications do not greatly perturb the protein structure at pH7 and 27 degrees C, at higher temperature or at alkaline pH some parts of the structure are markedly perturbed.	Lysine	20-26	cytochrome c, somatic	Equus caballus	136-148
6311171-4	1983	spectroscopy of the lysine-modified proteins N epsilon-acetimidyl-, N epsilon-amidino-, N epsilon-trifluoroacetyl- and N epsilon-maleyl-cytochrome c have shown that, although the lysine modifications do not greatly perturb the protein structure at pH7 and 27 degrees C, at higher temperature or at alkaline pH some parts of the structure are markedly perturbed.	Lysine	179-185	cytochrome c, somatic	Equus caballus	136-148
22809283-4	2012	This coincided with more pronounced losses of myosin in oxidized samples (up to 33.2%) as compared to 21.1% in nonoxidized (P &lt; 0.05), which was attributed to glutamine-lysine cross-linking as suggested by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Lysine	172-178	myosin heavy chain 14	Homo sapiens	46-52
15262146-1	2004	OBJECTIVE: The mature eukaryotic translation initiation factor 5A contains the unusual amino acid hypusine, formed post-translationally from a specific lysine residue and essential for proliferation of eukaryotic cells.	Lysine	152-158	eukaryotic translation initiation factor 5A	Homo sapiens	22-65
6311172-5	1983	Spectroscopic measurements of pKa values for Lys-55 (horse and tuna cytochromes c) and His-33 and His-39 (C. krusei and S. cerevisiae cytochromes c) are in excellent agreement with expectations based on chemical-modification studies of horse cytochrome c.	Lysine	45-48	cytochrome c, somatic	Equus caballus	242-254
6411930-8	1983	sgs-3 differs from sgs-7 and sgs-8 by containing a third module between the other two, comprised largely of tandem repeats of the five amino acids Pro-Thr-Thr-Thr-Lys.	Lysine	163-166	Salivary gland secretion 3	Drosophila melanogaster	0-5
15054101-9	2004	Sequence comparison of the two porin isoforms indicates the exchange of four lysines in DmPorin1 for four glutamic acids in DmPorin2.	Lysine	77-84	porin	Drosophila melanogaster	31-36
15054101-9	2004	Sequence comparison of the two porin isoforms indicates the exchange of four lysines in DmPorin1 for four glutamic acids in DmPorin2.	Lysine	77-84	porin	Drosophila melanogaster	88-96
15054101-9	2004	Sequence comparison of the two porin isoforms indicates the exchange of four lysines in DmPorin1 for four glutamic acids in DmPorin2.	Lysine	77-84	Porin2	Drosophila melanogaster	124-132
22692198-4	2012	Here we show that, in the absence of Tyr-211 phosphorylation, PCNA is subject to polyubiquitylation at Lys-164 by the CUL4A E3 ligase, resulting in the degradation of PCNA.	Lysine	103-106	proliferating cell nuclear antigen	Homo sapiens	62-66
6411928-6	1983	The complementation pattern observed and the corresponding expression of the lysA gene show that in fact the Lys- phenotype can be obtained by mutations in two different and closely linked loci: one being the lysA structural gene, and the other called lysR.	Lysine	109-112	transcriptional regulator, LysR family	Escherichia coli	252-256
22665495-4	2012	Lysine residues 76 and 81, located at the WASp WH1 domain, which contains the vast majority of WASp gene mutations, serve as the ubiquitylation sites.	Lysine	0-6	WASP actin nucleation promoting factor	Homo sapiens	42-46
22665495-4	2012	Lysine residues 76 and 81, located at the WASp WH1 domain, which contains the vast majority of WASp gene mutations, serve as the ubiquitylation sites.	Lysine	0-6	WASP actin nucleation promoting factor	Homo sapiens	95-99
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Lysine	43-46	flap structure-specific endonuclease 1	Homo sapiens	64-69
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Lysine	131-134	flap structure-specific endonuclease 1	Homo sapiens	64-69
6863249-7	1983	An additional hydrogen bond can be formed by bridging of the epsilon-amino group of beta-66 (Lys) between a heme propionate from cytochrome b5 and a beta-chain heme propionate.	Lysine	93-96	cytochrome b5 type A	Homo sapiens	129-142
6845437-2	1983	Moderately lysine-rich histones H2A and H2B were found to be more susceptible to acetylation than arginine-rich H3 and H4.	Lysine	11-17	H2B clustered histone 21	Homo sapiens	40-43
15147900-2	2004	It has been proposed that TRAF6, a RING finger-containing protein, acts as a ubiquitin ligase (E3) and a target for Lys-63 linked polyubiquitination mediated by Ubc13-Uev, a ubiquitin conjugating (E2) complex.	Lysine	116-119	TNF receptor associated factor 6	Homo sapiens	26-31
15147900-2	2004	It has been proposed that TRAF6, a RING finger-containing protein, acts as a ubiquitin ligase (E3) and a target for Lys-63 linked polyubiquitination mediated by Ubc13-Uev, a ubiquitin conjugating (E2) complex.	Lysine	116-119	ubiquitin conjugating enzyme E2 N	Homo sapiens	161-166
22802671-1	2012	The complex of lysine-specific demethylase-1 (LSD1/KDM1A) with its corepressor protein CoREST is an exceptionally relevant target for epigenetic drugs.	Lysine	15-21	REST corepressor 1	Homo sapiens	87-93
22605335-0	2012	Analysis of nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-kappaB.	Lysine	95-101	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	67-71
22605335-3	2012	Full-length NEMO can also interact with Lys-11-, Lys-48-, and Lys-63-linked ubiquitin chains of varying length in cells.	Lysine	40-43	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	12-16
22605335-3	2012	Full-length NEMO can also interact with Lys-11-, Lys-48-, and Lys-63-linked ubiquitin chains of varying length in cells.	Lysine	49-52	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	12-16
15082759-7	2004	We demonstrate that the hnRNP C proteins are modified by SUMO at a single lysine residue, K237, and that SUMO modification at this site decreases their binding to nucleic acids.	Lysine	74-80	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	24-31
22605335-3	2012	Full-length NEMO can also interact with Lys-11-, Lys-48-, and Lys-63-linked ubiquitin chains of varying length in cells.	Lysine	49-52	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	12-16
6817800-0	1982	Changes of lysine reactivities of actin in complex with myosin subfragment-1, tropomyosin and troponin.	Lysine	11-17	myosin heavy chain 14	Homo sapiens	56-62
22605335-4	2012	Here, we show that purified full-length NEMO binds preferentially to linear ubiquitin chains in competition with lysine-linked ubiquitin chains of defined length, including long Lys-63-linked deca-ubiquitins.	Lysine	113-119	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	40-44
22605335-4	2012	Here, we show that purified full-length NEMO binds preferentially to linear ubiquitin chains in competition with lysine-linked ubiquitin chains of defined length, including long Lys-63-linked deca-ubiquitins.	Lysine	178-181	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	40-44
22605335-6	2012	In TNFalpha-stimulated cells, NEMO chimeras engineered to bind exclusively to Lys-63-linked ubiquitin chains mediated partial NF-kappaB activation compared with cells expressing NEMO that binds to linear ubiquitin chains.	Lysine	78-81	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	30-34
22605335-7	2012	We propose that NEMO functions as a high affinity receptor for linear ubiquitin chains and a low affinity receptor for long lysine-linked ubiquitin chains.	Lysine	124-130	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	16-20
15082760-4	2004	Addition of the nuclear export inhibitor leptomycin B caused both overexpressed wild-type and endogenous SH2-B beta to accumulate in the nucleus of both PC12 cells and COS-7 cells as did deletion of a putative nuclear export sequence (amino acids 224 to 233) or mutation of two critical lysines in that sequence.	Lysine	287-294	SH2B adaptor protein 1	Rattus norvegicus	105-110
14982931-1	2004	Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28.	Lysine	114-120	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	0-4
14982931-1	2004	Hint, histidine triad nucleotide-binding protein, is a universally conserved enzyme that hydrolyzes AMP linked to lysine and, in yeast, functions as a positive regulator of the RNA polymerase II C-terminal domain kinase, Kin28.	Lysine	114-120	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	221-226
6817800-4	1982	Myosin subfragment-1 reduced the reactivities of Lys-335 and Lys-372, while tropomyosin reduced those of Lys-237, -325, 327 and -335.	Lysine	49-52	myosin heavy chain 14	Homo sapiens	0-6
15099517-1	2004	SET9 is a member of the SET domain-containing histone methyltransferase family that can specifically methylate histone 3 at lysine 4 position.	Lysine	124-130	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
15099517-3	2004	Here, we show that SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the putative histone-fold domain of the protein.	Lysine	86-92	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	19-23
6817800-4	1982	Myosin subfragment-1 reduced the reactivities of Lys-335 and Lys-372, while tropomyosin reduced those of Lys-237, -325, 327 and -335.	Lysine	61-64	myosin heavy chain 14	Homo sapiens	0-6
15099517-3	2004	Here, we show that SET9 can monomethylate the TBP-associated factor TAF10 at a single lysine residue located at the loop 2 region within the putative histone-fold domain of the protein.	Lysine	86-92	TATA-box binding protein associated factor 10	Homo sapiens	68-73
6817800-4	1982	Myosin subfragment-1 reduced the reactivities of Lys-335 and Lys-372, while tropomyosin reduced those of Lys-237, -325, 327 and -335.	Lysine	61-64	myosin heavy chain 14	Homo sapiens	0-6
14752096-0	2004	AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.	Lysine	77-83	RUNX family transcription factor 1	Homo sapiens	0-4
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	75-81	RUNX family transcription factor 1	Homo sapiens	49-53
7124951-9	1982	However, lysine (5 mM) and low perfusate calcium concentration (0.5 mM) inhibited T beta 2M but not TCYT c and ThGH.	Lysine	9-15	beta-2-microglobulin	Homo sapiens	84-91
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	92-95	RUNX family transcription factor 1	Homo sapiens	49-53
14752096-5	2004	Mutagenesis analyses reveal that p300 acetylates AML1 at the two conserved lysine residues (Lys-24 and Lys-43).	Lysine	103-106	RUNX family transcription factor 1	Homo sapiens	49-53
14752096-7	2004	Disruption of these two lysines severely impairs DNA binding of AML1 and reduced the transcriptional activity and the transforming potential of AML1.	Lysine	24-31	RUNX family transcription factor 1	Homo sapiens	64-68
14752096-7	2004	Disruption of these two lysines severely impairs DNA binding of AML1 and reduced the transcriptional activity and the transforming potential of AML1.	Lysine	24-31	RUNX family transcription factor 1	Homo sapiens	144-148
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	92-98	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	84-88
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	92-98	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	139-143
22556262-4	2012	We found that SETD8 methylated PCNA on lysine 248, and either depletion of SETD8 or substitution of lysine 248 destabilized PCNA expression.	Lysine	100-106	proliferating cell nuclear antigen	Homo sapiens	124-128
7200983-4	1982	The relative rate of RBP synthesis was estimated by measuring the extent of incorporation of [3H]leucine, [3H]lysine, and [3H]phenylalanine after a 12-min pulse label into immunoprecipitable RBP, relative to the incorporation of these amino acids into total liver trichloroacetic acid-precipitable protein.	Lysine	110-116	retinol binding protein 4	Rattus norvegicus	21-24
22556262-5	2012	Mechanistically, lysine methylation significantly enhanced the interaction between PCNA and the flap endonuclease FEN1.	Lysine	17-23	proliferating cell nuclear antigen	Homo sapiens	83-87
22556262-5	2012	Mechanistically, lysine methylation significantly enhanced the interaction between PCNA and the flap endonuclease FEN1.	Lysine	17-23	flap structure-specific endonuclease 1	Homo sapiens	114-118
22556262-8	2012	Together, our findings reveal a function for lysine methylation on a nonhistone protein and suggest that aberrant lysine methylation of PCNA may play a role in human carcinogenesis.	Lysine	45-51	proliferating cell nuclear antigen	Homo sapiens	136-140
22556262-8	2012	Together, our findings reveal a function for lysine methylation on a nonhistone protein and suggest that aberrant lysine methylation of PCNA may play a role in human carcinogenesis.	Lysine	114-120	proliferating cell nuclear antigen	Homo sapiens	136-140
15031712-2	2004	The trxG proteins Ash1 and hTRX and the PcG repressor E(z) are histone methyltransferases (HMTases) that methylate distinct lysine residues in the N-terminal tail of histone H3.	Lysine	124-130	thioredoxin	Homo sapiens	27-31
15039296-0	2004	Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).	Lysine	30-36	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	84-103
15039296-0	2004	Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).	Lysine	30-36	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	105-111
7049235-4	1982	Therefore, it was possible to measure the distances between Cys-70 of L10 and Lys-51 and the N terminus of each L7/L12 dimer.	Lysine	78-81	ribosomal protein L12	Homo sapiens	115-118
15024081-1	2004	Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4).	Lysine	197-203	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	166-170
22751501-3	2012	Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1.	Lysine	63-70	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	Homo sapiens	37-42
22751501-3	2012	Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1.	Lysine	63-70	RAD21 cohesin complex component	Homo sapiens	94-98
6281781-2	1982	When less than 15% of the lysine residues of human LDL were modified by malondialdehyde while the lipoprotein was in solution, recognition and uptake of the modified lipoprotein occurred via the LDL receptor.	Lysine	26-32	low density lipoprotein receptor	Homo sapiens	195-207
22019351-7	2012	This mutation resulted in the deletion of a lysine at position 123 (p.lys123del) in the lamin A/C protein.	Lysine	44-50	lamin A/C	Homo sapiens	88-97
15020763-3	2004	The glutamate at P6, which is formed by tissue transglutaminase-catalyzed deamidation, is an important anchor residue as it participates in an extensive hydrogen-bonding network involving Lys-beta71 of DQ2.	Lysine	188-191	torsin family 1 member A	Homo sapiens	202-205
6282265-1	1982	The mitochondrial cytochrome c-557 of Crithidia oncopelti contains two lysine residues and an N-terminal proline residue that are methylated in vivo by the methyl group of methionine.	Lysine	71-77	cytochrome c, somatic	Equus caballus	18-30
14665632-5	2004	Although the p33ING1-Sin3-HDAC and DMAP1-DNMT1 complexes are recruited independently to pericentric heterochromatin regions, they are both required for deacetylation of histones and methylation of histone H3 at lysine 9.	Lysine	211-217	inhibitor of growth family member 1	Homo sapiens	13-20
14665632-5	2004	Although the p33ING1-Sin3-HDAC and DMAP1-DNMT1 complexes are recruited independently to pericentric heterochromatin regions, they are both required for deacetylation of histones and methylation of histone H3 at lysine 9.	Lysine	211-217	SIN3 transcription regulator family member A	Homo sapiens	21-25
14699168-2	2004	P2X receptors comprise a family of ATP-gated ion channels with the basic amino acids Lys-68, Arg-292, and Lys-309 (P2X(1) receptor numbering) contributing to agonist potency.	Lysine	85-88	purinergic receptor P2X 1	Homo sapiens	115-130
14699168-2	2004	P2X receptors comprise a family of ATP-gated ion channels with the basic amino acids Lys-68, Arg-292, and Lys-309 (P2X(1) receptor numbering) contributing to agonist potency.	Lysine	106-109	purinergic receptor P2X 1	Homo sapiens	115-130
14699168-12	2004	These results suggest that residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP.	Lysine	36-39	purinergic receptor P2X 1	Homo sapiens	115-121
22544915-0	2012	Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification.	Lysine	128-134	HIC ZBTB transcriptional repressor 1	Homo sapiens	29-33
6282265-9	1982	254, 4645-4652] in that lysine-72 of horse cytochrome c is a poor acceptor.	Lysine	24-30	cytochrome c, somatic	Equus caballus	43-55
14699168-12	2004	These results suggest that residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP.	Lysine	75-78	purinergic receptor P2X 1	Homo sapiens	115-121
6174372-0	1982	Proteolysis at a lysine residue abolishes the receptor-recognition site of alpha 2-macroglobulin complexes.	Lysine	17-23	alpha-2-macroglobulin	Homo sapiens	75-96
15025528-5	2004	RAP was purified using a bacterial expression system and coupled to poly-D-lysine (PDL) or poly-L-lysine (PLL) of average MW 50 kDa via the heterobifunctional cross-linker SPDP.	Lysine	91-104	LDL receptor related protein associated protein 1	Homo sapiens	0-3
22792074-0	2012	FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.	Lysine	27-33	BRCA1 interacting helicase 1	Homo sapiens	0-5
7053363-6	1982	T-protein is a basic protein having a pI value of 9.8 and relatively rich in arginine rather than lysine.	Lysine	98-104	aminomethyltransferase	Gallus gallus	0-9
22792074-4	2012	Preventing FANCJ acetylation at lysine 1249 does not interfere with the ability of cells to survive DNA interstrand crosslinks (ICLs).	Lysine	32-38	BRCA1 interacting helicase 1	Homo sapiens	11-16
22792074-8	2012	Furthermore, both preventing and mimicking FANCJ acetylation at lysine 1249 disrupts FANCJ function in checkpoint maintenance.	Lysine	64-70	BRCA1 interacting helicase 1	Homo sapiens	43-48
22792074-8	2012	Furthermore, both preventing and mimicking FANCJ acetylation at lysine 1249 disrupts FANCJ function in checkpoint maintenance.	Lysine	64-70	BRCA1 interacting helicase 1	Homo sapiens	85-90
22555612-2	2012	Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1.	Lysine	61-67	protein inhibitor of activated STAT 1	Homo sapiens	115-120
14985069-4	2004	RESULTS: Arginine-aminopeptidase found in cardiac fibroblasts (Fb) was arginine and lysine specific, sensitive to various aminopeptidase (AP) inhibitors and to the inhibitor of metalloproteases, 1.10-phenatroline.	Lysine	84-90	arginyl aminopeptidase	Rattus norvegicus	9-32
14660555-7	2004	Furthermore, we show for the first time that Fyn is trimethylated at lysine residues 7 and/or 9 within its N-terminal region.	Lysine	69-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
14660555-10	2004	Lysine mutants of Fyn that could not be methylated failed to promote cell adhesion and spreading, suggesting that methylation is important for Fyn function.	Lysine	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
6462134-7	1981	Heparin must bind to plasmin to accelerate the plasmin-antithrombin III reaction, since the modification of four to five lysine residues of the enzyme inhibits the rate-enhancement effect of heparin and the dissociation of heparin-plasmin complex decreases the inactivation rate of plasmin.	Lysine	121-127	serpin family C member 1	Homo sapiens	55-71
14660555-10	2004	Lysine mutants of Fyn that could not be methylated failed to promote cell adhesion and spreading, suggesting that methylation is important for Fyn function.	Lysine	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Lysine	107-110	defensin, alpha, 20	Mus musculus	9-19
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Lysine	107-110	defensin, alpha, 20	Mus musculus	21-25
22566697-3	2012	Lys-for-Arg mutagenesis attenuates Crp4, but RMAD4 activity remains mostly unchanged.	Lysine	0-3	defensin, alpha, 20	Mus musculus	35-39
7299136-8	1981	These results suggest that the positively charged residues His-285, Lys-288, Lys-290, and Arg-292, which are located on the outer surface of the C gamma 2 domain, may be involved in the C1q-binding site of human IgG.	Lysine	68-71	complement C1q A chain	Homo sapiens	186-189
22566697-5	2012	In Crp4, small-angle x-ray scattering analyses showed that Arg-to-Lys replacements shifted the induced nanoporous phases to a different range of lipid compositions compared with the Arg-rich native peptide, consistent with the attenuation of bactericidal activity by Lys-for-Arg mutations.	Lysine	66-69	defensin, alpha, 20	Mus musculus	3-7
22682226-0	2012	Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.	Lysine	90-97	hepcidin antimicrobial peptide	Homo sapiens	23-31
22682227-6	2012	Substitutions of lysines between residues 229 and 269 in the third cytoplasmic loop of ferroportin prevented hepcidin-dependent ubiquitination and endocytosis of ferroportin, and promoted cellular iron export even in the presence of hepcidin.	Lysine	17-24	hepcidin antimicrobial peptide	Homo sapiens	109-117
22682227-6	2012	Substitutions of lysines between residues 229 and 269 in the third cytoplasmic loop of ferroportin prevented hepcidin-dependent ubiquitination and endocytosis of ferroportin, and promoted cellular iron export even in the presence of hepcidin.	Lysine	17-24	hepcidin antimicrobial peptide	Homo sapiens	233-241
14757744-7	2004	Most intriguingly, the CDR3 regions of the ANAs exhibited alternating arginine/lysine peaks at H96, H98, and H100, with neutral troughs at H95, H97, and H99.	Lysine	79-85	cerebellar degeneration-related 3	Mus musculus	23-27
14751456-4	2004	The binding of [3H]LY 278584 to 5-HT(3) receptors was significantly reduced in frontal cortex, CA1 region of hippocampus, and in the medial and lateral nuclei of the amygdala of FH/Wjd versus ACI/N rats.	Lysine	19-21	carbonic anhydrase 1	Rattus norvegicus	95-98
7299136-8	1981	These results suggest that the positively charged residues His-285, Lys-288, Lys-290, and Arg-292, which are located on the outer surface of the C gamma 2 domain, may be involved in the C1q-binding site of human IgG.	Lysine	77-80	complement C1q A chain	Homo sapiens	186-189
7028141-1	1981	An intramolecular modification of insulin at the alpha-amino group of glycine (A1) and the epsilon-amino group of lysine (B29) was carried out.	Lysine	114-120	CD79b molecule	Homo sapiens	122-125
14737116-7	2004	Efficient growth arrest by p16/Rb is dependent on histone H3 lysine 9 methylation, which provides a binding site for HP1.	Lysine	61-67	chromobox 5	Homo sapiens	117-120
14660634-2	2004	Given the requirement of Rad6/Bre1-dependent ubiquitination of histone H2B for H3 dimethylation (at lysines 4 and 79) and gene silencing (2-7), removal of ubiquitin from H2B may have a significant regulatory effect on transcription.	Lysine	100-107	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	25-29
22101407-6	2012	MYST2 and SUV420H2 regulate the levels of the epigenetic biomarkers histone H4 lysine 16 acetylation (H4K16ac) and histone H4 lysine 20 trimethylation (H4K20me3), respectively.	Lysine	79-85	lysine acetyltransferase 7	Homo sapiens	0-5
6114810-2	1981	Negatively charged elastin ligands, including fatty acids, bile salts or sodium dodecyl sulfate can completely inhibit the oxidation of lysine in elastin, the cationic amphiphilic ligands stimulate the enzymatic reaction five-fold, while small hydrophilic molecules of either charge or neutral detergents have no effect.	Lysine	136-142	elastin	Bos taurus	19-26
22101407-6	2012	MYST2 and SUV420H2 regulate the levels of the epigenetic biomarkers histone H4 lysine 16 acetylation (H4K16ac) and histone H4 lysine 20 trimethylation (H4K20me3), respectively.	Lysine	79-85	lysine methyltransferase 5C	Homo sapiens	10-18
22101407-6	2012	MYST2 and SUV420H2 regulate the levels of the epigenetic biomarkers histone H4 lysine 16 acetylation (H4K16ac) and histone H4 lysine 20 trimethylation (H4K20me3), respectively.	Lysine	126-132	lysine acetyltransferase 7	Homo sapiens	0-5
22101407-6	2012	MYST2 and SUV420H2 regulate the levels of the epigenetic biomarkers histone H4 lysine 16 acetylation (H4K16ac) and histone H4 lysine 20 trimethylation (H4K20me3), respectively.	Lysine	126-132	lysine methyltransferase 5C	Homo sapiens	10-18
14723728-2	2004	Direct sequencing identified a heterozygous A --&gt; C substitution at nucleotide 596 altering codon 199 of KRT5 from lysine to threonine in all affected family members, but not in the unaffected family members or in 50 unrelated control samples.	Lysine	118-124	keratin 5	Homo sapiens	108-112
14723728-4	2004	This mutated lysine residue is sited within the 1A domain of keratin 5 and is highly conserved among all type II keratins.	Lysine	13-19	keratin 5	Homo sapiens	61-70
22434078-8	2012	There were lower acetylation and higher methylation levels of histone H3 at lysine 9 of the promoter of adiponectin in adipose tissues of OH mice at 2 wk of age as well as at 12 and 24 wk of age compared with OC mice.	Lysine	76-82	adiponectin, C1Q and collagen domain containing	Mus musculus	104-115
6114810-2	1981	Negatively charged elastin ligands, including fatty acids, bile salts or sodium dodecyl sulfate can completely inhibit the oxidation of lysine in elastin, the cationic amphiphilic ligands stimulate the enzymatic reaction five-fold, while small hydrophilic molecules of either charge or neutral detergents have no effect.	Lysine	136-142	elastin	Bos taurus	146-153
22434078-9	2012	In contrast, methylation of histone 4 at lysine 20 in the leptin promoter was significantly higher in OH compared with OC mice.	Lysine	41-47	leptin	Mus musculus	58-64
6449829-7	1980	It is suggested that the reduced extent of activation of factor XII observed in plasma from rats injected intravenously with dextran, or rat plasma that has been passed through a column with lysine-Sepharose, is due to the loss of functional HMWK caused by plasmin activated in vivo or on the column.	Lysine	191-197	coagulation factor XII	Rattus norvegicus	57-67
22493065-0	2012	Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.	Lysine	112-118	sarcoplasmic calcium-binding protein	Drosophila melanogaster	69-72
22493065-2	2012	We previously showed that the Drosophila melanogaster acetyltransferase CREB-binding protein (CBP) acetylates histone H3 lysine 27 (H3K27ac), thereby directly blocking its trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) in Polycomb target genes.	Lysine	121-127	sarcoplasmic calcium-binding protein	Drosophila melanogaster	94-97
22787431-3	2012	We show here that APC binds to the nuclear localization sequence of Fen1 (Lys(365)Lys(366)Lys(367)), which prevents entry of Fen1 into the nucleus and participation in Pol-beta-directed long-patch BER.	Lysine	74-77	flap structure-specific endonuclease 1	Homo sapiens	68-72
22787431-3	2012	We show here that APC binds to the nuclear localization sequence of Fen1 (Lys(365)Lys(366)Lys(367)), which prevents entry of Fen1 into the nucleus and participation in Pol-beta-directed long-patch BER.	Lysine	74-77	flap structure-specific endonuclease 1	Homo sapiens	125-129
15001841-4	2004	Docking of this molecule onto the P-selectin carbohydrate-binding site demonstrated that a nitro group enabled an electrostatic interaction with residue Lys 84, while the phenyl ring and the CH2 at C-6 contacted the CH2 groups of the same Lys residue.	Lysine	153-156	selectin P	Homo sapiens	34-44
15001841-4	2004	Docking of this molecule onto the P-selectin carbohydrate-binding site demonstrated that a nitro group enabled an electrostatic interaction with residue Lys 84, while the phenyl ring and the CH2 at C-6 contacted the CH2 groups of the same Lys residue.	Lysine	239-242	selectin P	Homo sapiens	34-44
15505399-1	2004	Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase, an enzyme responsible for the catabolism of lysine, hydroxylysine and tryptophan.	Lysine	155-161	glutaryl-CoA dehydrogenase	Homo sapiens	83-109
6159774-6	1980	Previous experiments with rat plasma demonstrated that plasmin and also a plasmin-like factor without affinity for lysine-Sepharose were able to destroy the capacity of HMWK to function as a cofactor in the surface-dependent activation of factor XII, without a corresponding release of kinin.	Lysine	115-121	coagulation factor XII	Rattus norvegicus	239-249
22626058-3	2012	RESULTS: We report here that RLR activation triggers MAVS ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling.	Lysine	76-82	mitochondrial antiviral signaling protein	Homo sapiens	53-57
6254024-0	1980	Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues.	Lysine	88-94	cytochrome c, somatic	Equus caballus	34-46
22457348-9	2012	Two amino acids (lysine 715 and arginine 716) of the TRPC4 C terminus were identified by structural modeling as mediating the interaction with Galpha(i2).	Lysine	17-23	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	143-152
15160493-0	2004	Engineering lysine reactivity as a conformational sensor in the Dictyostelium myosin II motor domain.	Lysine	12-18	myosin heavy chain 14	Homo sapiens	78-84
15160493-4	2004	By following trinitrophenylation of the mutant constructs, we first unambiguously identify Lys84 as the reactive lysine in Dictyostelium myosin.	Lysine	113-119	myosin heavy chain 14	Homo sapiens	137-143
6244857-0	1980	Enzymatic trimethylation of residue-72 lysine in cytochrome c.	Lysine	39-45	cytochrome c, somatic	Equus caballus	49-61
15263846-3	2004	Ulp1 (SUMO protease 1) processes the SUMO precursor to its mature form and also de-conjugates SUMO from side chain lysines of target proteins.	Lysine	115-122	SUMO protease ULP1	Saccharomyces cerevisiae S288C	0-4
14701748-0	2004	Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues of histone and nonhistone proteins.	Lysine	185-191	histone deacetylase 8	Homo sapiens	23-44
22431730-1	2012	The Set1 complex (also known as complex associated with Set1 or COMPASS) methylates histone H3 on lysine 4, with different levels of methylation affecting transcription by recruiting various factors to distinct regions of active genes.	Lysine	98-104	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	4-8
22431730-1	2012	The Set1 complex (also known as complex associated with Set1 or COMPASS) methylates histone H3 on lysine 4, with different levels of methylation affecting transcription by recruiting various factors to distinct regions of active genes.	Lysine	98-104	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	56-60
22510409-5	2012	SIRT1 is also responsible of the deacetylation of the lysine 314 of HIC1 that allows its subsequent SUMOylation which in turn favors its interaction with the NuRD complex.	Lysine	54-60	HIC ZBTB transcriptional repressor 1	Homo sapiens	68-72
6244857-2	1980	A highly purified protein methylase III from Neurospora crassa or Saccharomyces cerevisiae specifically methylates a single lysine residue of position 72 of horse heart cytochrome c.	Lysine	124-130	cytochrome c, somatic	Equus caballus	169-181
14676321-0	2003	L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats.	Lysine	0-8	5-hydroxytryptamine receptor 4	Rattus norvegicus	29-49
6244857-6	1980	Space-filling models revealed the possibility of a hydrogen bond between the oxygen of amide of residue-70 asparagine and the epsilon-amino nitrogen of residue-72 lysine in unmethylated horse heart cytochrome C.	Lysine	163-169	cytochrome c, somatic	Equus caballus	198-210
14676321-1	2003	The purpose of this investigation was to determine whether a nutritionally essential amino acid, l-lysine, acts like a serotonin receptor 4 (5-HT4) antagonist, and if l-lysine is beneficial in animal models of serotonin (5-HT)-induced anxiety, diarrhea, ileum contractions, and tachycardia and in stress-induced fecal excretion.	Lysine	97-105	5-hydroxytryptamine receptor 4	Rattus norvegicus	119-139
7441383-9	1980	From discussions on the above findings it is presumed that 15N urea may be utilized in PNG highlanders and Japanese controls of LPD to produce amino acids, especially lysine in the intestine where the bacterial species are changed by a long-continued protein-deficient diet from those of Japanese controls of SPD.	Lysine	167-173	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	128-131
14522996-1	2003	Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose.	Lysine	133-139	sirtuin 2	Homo sapiens	0-30
21963854-6	2012	p53 pre-methylated at lysine-372 (p53K372 mono-methylation) by SET7 protects p53 from E6-induced degradation.	Lysine	22-28	KMT5A pseudogene 1	Homo sapiens	63-67
22652693-1	2012	Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans).	Lysine	29-35	lysine methyltransferase 2A	Homo sapiens	154-158
14522996-1	2003	Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose.	Lysine	133-139	sirtuin 2	Homo sapiens	32-36
158524-2	1979	The loss of reactivity of the streptokinase-plasmin complex towards alpha 2-antiplasmin is independent of the lysine binding sites in plasmin since low-Mr plasmin, which lacks these sites, and plasmin in which the sites have been blocked by 6-aminohexanoic acid, are both equally unreactive towards alpha 2-antiplasmin on reaction with streptokinase.	Lysine	110-116	plasminogen	Bos taurus	44-51
92520-8	1979	Tobacco hornworm moth cytochrome c, which contains a glutamine at residue 100 but a terminal lysine at residue 103 (one amino acid closer to the glutamine), stimulated pigeon cytochrome c immune T cells better than the immunogen.	Lysine	93-99	cytochrome c, somatic	Gallus gallus	22-34
14641038-10	2003	Treatment with the proteasomal inhibitor lactacystin increased the cytotoxicity of the lysine-enriched RTA to a level approaching that of wild-type RTA.	Lysine	87-93	MAS related GPR family member F	Homo sapiens	103-106
14641038-10	2003	Treatment with the proteasomal inhibitor lactacystin increased the cytotoxicity of the lysine-enriched RTA to a level approaching that of wild-type RTA.	Lysine	87-93	MAS related GPR family member F	Homo sapiens	148-151
22205538-2	2012	A guanine (G)/adenine (A) common single nucleotide polymorphism at first position of codon 589 in Exo 1 gene determines a glutamic acid (Glu, E) to lysine (Lys, K) (K589E) aminoacidic substitution which may alter cancer risk by influencing the activity of Exo 1 protein.	Lysine	148-154	exonuclease 1	Homo sapiens	98-103
22205538-2	2012	A guanine (G)/adenine (A) common single nucleotide polymorphism at first position of codon 589 in Exo 1 gene determines a glutamic acid (Glu, E) to lysine (Lys, K) (K589E) aminoacidic substitution which may alter cancer risk by influencing the activity of Exo 1 protein.	Lysine	148-154	exonuclease 1	Homo sapiens	256-261
22205538-2	2012	A guanine (G)/adenine (A) common single nucleotide polymorphism at first position of codon 589 in Exo 1 gene determines a glutamic acid (Glu, E) to lysine (Lys, K) (K589E) aminoacidic substitution which may alter cancer risk by influencing the activity of Exo 1 protein.	Lysine	156-159	exonuclease 1	Homo sapiens	98-103
22205538-2	2012	A guanine (G)/adenine (A) common single nucleotide polymorphism at first position of codon 589 in Exo 1 gene determines a glutamic acid (Glu, E) to lysine (Lys, K) (K589E) aminoacidic substitution which may alter cancer risk by influencing the activity of Exo 1 protein.	Lysine	156-159	exonuclease 1	Homo sapiens	256-261
14983093-0	2003	Isolation from phage display libraries of lysine-deficient human epidermal growth factor variants for directional conjugation as targeting ligands.	Lysine	42-48	epidermal growth factor	Homo sapiens	65-88
14983093-3	2003	In this paper, we describe the isolation by phage display of human epidermal growth factor (EGF) variants without lysine and a reduced number of arginine residues.	Lysine	114-120	epidermal growth factor	Homo sapiens	67-90
222754-2	1979	All the lysines of horse heart cytochrome c were maleylated yielding a low spin product.	Lysine	8-15	cytochrome c, somatic	Equus caballus	31-43
14983093-3	2003	In this paper, we describe the isolation by phage display of human epidermal growth factor (EGF) variants without lysine and a reduced number of arginine residues.	Lysine	114-120	epidermal growth factor	Homo sapiens	92-95
14616797-6	2003	Anti-PR3 or anti-MPO induced an FcgammaRIIa-dependent burst in TNF-primed neutrophils incubated in wells coated with poly-L-lysine, known to induce beta2-integrin-independent adhesion, but this reaction was still inhibited by blocking CD18 antibodies.	Lysine	117-130	lymphotoxin beta receptor	Homo sapiens	235-239
22505724-2	2012	Ubiquitin is a small protein modifier that is adducted to lysine residues by the combined function of E1, E2, and E3 enzymes and is removed by deubiquitinating enzymes.	Lysine	58-64	small nucleolar RNA, H/ACA box 73A	Homo sapiens	102-116
22373579-2	2012	The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20.	Lysine	185-191	tumor protein p53 binding protein 1	Homo sapiens	19-24
14636589-1	2003	Set1p methylates lysine 4 (K4) of histone H3 and regulates the expression of many genes in yeast.	Lysine	17-23	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	0-5
514636-1	1979	Kappa-Elastin is exhaustively guanidinated in order to chemically modify the pre-existing lysine content to homoarginine.	Lysine	90-96	elastin	Bos taurus	6-13
14576290-5	2003	In snc1, one of the TIR-NB-LRR-type R genes contains a point mutation that results in a single amino acid change from Glu to Lys in the region between NB-ARC and LRR.	Lysine	125-128	TIR-NBS-LRR class disease resistance protein	Arabidopsis thaliana	3-7
514636-6	1979	These results are similar to those obtained by photolysis of (Iso) desmosine residues by UV light which will liberate "new" lysine containing peptides from kappa-Elastin.	Lysine	124-130	elastin	Bos taurus	162-169
486492-6	1979	A highly purified ornithine decarboxylase preparation was able to decarboxylate lysine and the ratio of ornithine to lysine decarboxylase activities was constant throughout purification.	Lysine	80-86	ornithine decarboxylase 1	Rattus norvegicus	18-41
12920115-2	2003	These PB1 domains harbor either a conserved lysine residue on one side or an acidic OPCA (OPR/PC/AID) motif around the other side; the lysine of p67phox or Bem1p likely binds to the OPCA of p40phox or Cdc24p, respectively, via electrostatic interactions.	Lysine	135-141	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	156-161
22514307-2	2012	Here, we identify an essential role for the G9a/G9a-like protein (GLP) lysine dimethyltransferase complex and the histone H3 lysine 9 dimethylation (H3K9me2) marks it catalyzes, in the transcriptional regulation of genes in area CA1 of the rat hippocampus and the EC during memory consolidation.	Lysine	71-77	carbonic anhydrase 1	Rattus norvegicus	229-232
22375010-7	2012	Second, Drd2 transcriptional activation is partially antagonized by heterochromatin protein 1 (HP1), the code reader for histone H3 lysine 9 methylation.	Lysine	132-138	chromobox 5	Homo sapiens	68-93
22375010-7	2012	Second, Drd2 transcriptional activation is partially antagonized by heterochromatin protein 1 (HP1), the code reader for histone H3 lysine 9 methylation.	Lysine	132-138	chromobox 5	Homo sapiens	95-98
421686-1	1979	Antiserum obtained by immunizing a goat with lacto-N-difucohexaose I, a Leb blood-group hapten, coupled to poly-L-lysine was used in a radioimmunoassay to detect Leb-active oligosaccharides (chiefly lacto-N-difucohexaose I) in urine of 138 pregnant and lactating women of different ABO and Lewis blood groups.	Lysine	107-120	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	162-165
12876294-5	2003	Strains deleted for several components of the Paf1 complex are defective in monoubiquitination of histone H2B, which results in the loss of methylation of lysines 4 and 79 of histone H3.	Lysine	155-162	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	46-50
22386717-1	2012	Dihydrodipicolinate synthase is a key enzyme in the lysine biosynthesis pathway that catalyzes the condensation of pyruvate and aspartate semi-aldehyde.	Lysine	52-58	dihydrodipicolinate synthase	Escherichia coli	0-28
210807-10	1978	A line through the positive and negative charge centres, the dipole axis, crosses the tuna cytochrome c surface at Ala 83 (positive part) and Lys 99 (negative part).	Lysine	142-145	cytochrome c, somatic	Equus caballus	91-103
22402663-3	2012	Here, we demonstrate that the methyltransferase Set9 methylates FOXO3 at lysine 270.	Lysine	73-79	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	48-52
207344-11	1978	However, in the lipoproteins apoA-II, which contains lysine but no arginine, was cleaved more rapidly and extensively by agarose-trypsin than apoA-I.	Lysine	53-59	apolipoprotein A2	Homo sapiens	29-36
22402663-5	2012	Accordingly, lysine methylation reduces oxidative stress-induced and FOXO3-mediated Bim expression and neuronal apoptosis in neurons.	Lysine	13-19	BCL2 like 11	Homo sapiens	84-87
14499861-1	2003	OBJECTIVE: To determine whether the amino acid 897 threonine (T) to lysine (K) polymorphism of the KCNH2 (HERG) potassium channel influences channel performance or patient phenotype.	Lysine	68-74	potassium voltage-gated channel subfamily H member 2	Homo sapiens	99-104
14499861-1	2003	OBJECTIVE: To determine whether the amino acid 897 threonine (T) to lysine (K) polymorphism of the KCNH2 (HERG) potassium channel influences channel performance or patient phenotype.	Lysine	68-74	potassium voltage-gated channel subfamily H member 2	Homo sapiens	106-110
12788913-3	2003	The synthesis of deoxyhypusine catalyzed by this enzyme involves transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in the eIF5A precursor protein to form a deoxyhypusine-containing eIF5A intermediate, eIF5A(Dhp).	Lysine	129-135	eukaryotic translation initiation factor 5A	Homo sapiens	151-156
22160855-5	2012	Using chromatin immunoprecipitation coupled with real-time PCR technique, it was shown that the after induction of differentiation the repressive epigenetic marks of hypoacetylation and methylation on lysine-9 of histone H3 occurred very effectively on the upstream of Oct4, especially in PP region.	Lysine	201-207	POU class 5 homeobox 1	Homo sapiens	269-273
412965-2	1977	The synthesis of lysine analogues wherein blocking groups are substituted at position 5, the site of hydroxylation by peptidyl lysine hydroxylase, is described.	Lysine	17-23	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	127-145
22318720-5	2012	Simultaneous mutation of the C-domain and another subunit of the Paf1 complex, Rtf1, causes enhanced mutant phenotypes and loss of histone H3 lysine 36 trimethylation.	Lysine	142-148	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	65-69
22318720-5	2012	Simultaneous mutation of the C-domain and another subunit of the Paf1 complex, Rtf1, causes enhanced mutant phenotypes and loss of histone H3 lysine 36 trimethylation.	Lysine	142-148	RTF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	79-83
12788913-3	2003	The synthesis of deoxyhypusine catalyzed by this enzyme involves transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in the eIF5A precursor protein to form a deoxyhypusine-containing eIF5A intermediate, eIF5A(Dhp).	Lysine	129-135	eukaryotic translation initiation factor 5A	Homo sapiens	210-215
12788913-3	2003	The synthesis of deoxyhypusine catalyzed by this enzyme involves transfer of the 4-aminobutyl moiety of spermidine to a specific lysine residue in the eIF5A precursor protein to form a deoxyhypusine-containing eIF5A intermediate, eIF5A(Dhp).	Lysine	129-135	eukaryotic translation initiation factor 5A	Homo sapiens	210-215
856709-2	1977	The synthesis by conventional methods of the following three peptides is described: MCD(8-11) Boc-His(Trt)-Val-Ile-Lys(Z) (III) MCD(5-7) Boc-Cys(SiPr)-Lys(Z)-Arg(Tos) (IV) and MCD(1-4) Boc-Ile-Lys(Z)-Cys(Trt)-Asn(Mbh) (V).	Lysine	115-118	RAD21 cohesin complex component	Homo sapiens	176-183
12869583-2	2003	Less is known of the family of mammalian HP1 proteins, which may be euchromatic, targeted to expressed loci by repressor-corepressor complexes, and retained there by Lys 9-methylated histone H3 (H3-MeK9).	Lysine	166-169	chromobox 5	Homo sapiens	41-44
12759344-9	2003	Interestingly, PML mutants in which sumoylation at lysine 160 was inhibited displayed an increased association with MDM2, suggesting that sumoylation at this site may be a determinant of PML-MDM2 binding.	Lysine	51-57	PML nuclear body scaffold	Homo sapiens	15-18
12759344-9	2003	Interestingly, PML mutants in which sumoylation at lysine 160 was inhibited displayed an increased association with MDM2, suggesting that sumoylation at this site may be a determinant of PML-MDM2 binding.	Lysine	51-57	PML nuclear body scaffold	Homo sapiens	187-190
22364263-1	2012	Analysis of the in vivo ubiquitylation of the p54/Rpn10 polyubiquitin receptor subunit of the Drosophila 26S proteasome revealed that the site of ubiquitylation is the C-terminal cluster of lysines, which is conserved in higher eukaryotes.	Lysine	190-197	Regulatory particle non-ATPase 10	Drosophila melanogaster	46-49
22364263-1	2012	Analysis of the in vivo ubiquitylation of the p54/Rpn10 polyubiquitin receptor subunit of the Drosophila 26S proteasome revealed that the site of ubiquitylation is the C-terminal cluster of lysines, which is conserved in higher eukaryotes.	Lysine	190-197	Regulatory particle non-ATPase 10	Drosophila melanogaster	50-55
12885887-0	2003	PML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0.	Lysine	12-18	PML nuclear body scaffold	Homo sapiens	0-3
191160-0	1977	Ion binding to lysine-modified derivatives of cytochrome c.	Lysine	15-21	cytochrome c, somatic	Equus caballus	46-58
12885887-0	2003	PML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0.	Lysine	12-18	PML nuclear body scaffold	Homo sapiens	58-61
12885887-11	2003	Using a transfection-based approach and a family of deletion and point mutations of PML, we found that efficient ICP0-induced PML degradation requires sequences within the C-terminal part of PML and lysine residue 160, one of the principal targets for SUMO-1 modification of the protein.	Lysine	199-205	PML nuclear body scaffold	Homo sapiens	84-87
12885887-11	2003	Using a transfection-based approach and a family of deletion and point mutations of PML, we found that efficient ICP0-induced PML degradation requires sequences within the C-terminal part of PML and lysine residue 160, one of the principal targets for SUMO-1 modification of the protein.	Lysine	199-205	PML nuclear body scaffold	Homo sapiens	126-129
12885887-11	2003	Using a transfection-based approach and a family of deletion and point mutations of PML, we found that efficient ICP0-induced PML degradation requires sequences within the C-terminal part of PML and lysine residue 160, one of the principal targets for SUMO-1 modification of the protein.	Lysine	199-205	PML nuclear body scaffold	Homo sapiens	126-129
22311979-7	2012	Importantly, EBS deletion or Arg-337 and Lys-338 mutations abrogated PSGL-1-induced ERK activation, whereas they did not prevent Syk phosphorylation or E-selectin-induced leukocyte slow rolling.	Lysine	41-44	selectin P ligand	Homo sapiens	69-75
868650-3	1977	The synthesis of corsslinked elastin was shown by the isolation and identification of the lysine-derived crosslinks after incubating the cultures with [14C]-labeled lysine.	Lysine	90-96	LOC100620140	Sus scrofa	29-36
22275358-3	2012	The interaction of rhodopsin-attached phosphates with Lys-14 and Lys-15 in beta-strand I was shown to disrupt the interaction of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition into an active receptor-binding state.	Lysine	65-68	S-antigen visual arrestin	Homo sapiens	184-194
22275358-7	2012	BRET data confirmed the role of Lys-14 and Lys-15 in arrestin-1 binding to non-cognate receptors.	Lysine	32-35	S-antigen visual arrestin	Homo sapiens	53-63
22275358-7	2012	BRET data confirmed the role of Lys-14 and Lys-15 in arrestin-1 binding to non-cognate receptors.	Lysine	43-46	S-antigen visual arrestin	Homo sapiens	53-63
12834344-2	2003	A protein heterodimer composed of a catalytically active ubiquitin-conjugating enzyme (Ubc13) and its homologue (Mms2 or Uev1a) forms a catalytic scaffold upon which a noncovalently associated acceptor Ub and thiolester-linked donor Ub are oriented such that Lys(63)-linked poly-Ub chain synthesis is facilitated.	Lysine	259-262	ubiquitin conjugating enzyme E2 N	Homo sapiens	87-92
12834344-2	2003	A protein heterodimer composed of a catalytically active ubiquitin-conjugating enzyme (Ubc13) and its homologue (Mms2 or Uev1a) forms a catalytic scaffold upon which a noncovalently associated acceptor Ub and thiolester-linked donor Ub are oriented such that Lys(63)-linked poly-Ub chain synthesis is facilitated.	Lysine	259-262	ubiquitin conjugating enzyme E2 V2	Homo sapiens	113-117
12834344-2	2003	A protein heterodimer composed of a catalytically active ubiquitin-conjugating enzyme (Ubc13) and its homologue (Mms2 or Uev1a) forms a catalytic scaffold upon which a noncovalently associated acceptor Ub and thiolester-linked donor Ub are oriented such that Lys(63)-linked poly-Ub chain synthesis is facilitated.	Lysine	259-262	ubiquitin conjugating enzyme E2 V1	Homo sapiens	121-126
12834344-7	2003	In connection with previous structural studies for this system, the thermodynamics and kinetics of acceptor Ub binding to the Mms2.Ubc13 heterodimer described in detail in this study will allow for a more thorough rationalization of the mechanism of formation of Lys(63)-linked poly-Ub chains.	Lysine	263-266	ubiquitin conjugating enzyme E2 V2	Homo sapiens	126-130
12834344-7	2003	In connection with previous structural studies for this system, the thermodynamics and kinetics of acceptor Ub binding to the Mms2.Ubc13 heterodimer described in detail in this study will allow for a more thorough rationalization of the mechanism of formation of Lys(63)-linked poly-Ub chains.	Lysine	263-266	ubiquitin conjugating enzyme E2 N	Homo sapiens	131-136
22421046-1	2012	The histone H4 lysine 16 (H4K16)-specific acetyltransferase MOF is part of two distinct complexes involved in X chromosome dosage compensation and autosomal transcription regulation.	Lysine	15-21	males absent on the first	Drosophila melanogaster	60-63
868650-3	1977	The synthesis of corsslinked elastin was shown by the isolation and identification of the lysine-derived crosslinks after incubating the cultures with [14C]-labeled lysine.	Lysine	165-171	LOC100620140	Sus scrofa	29-36
12847084-6	2003	Polyubiquitin chains linked by lysine 48 are recognized in a synergistic manner by both p97 and an evolutionarily conserved ubiquitin-binding site at the NH2 terminus of Ufd1.	Lysine	31-37	polyubiquitin-binding protein UFD1	Saccharomyces cerevisiae S288C	170-174
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Lysine	101-104	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
12819771-5	2003	Differences in hydrogen bonding between the MeLys epsilon-amino group and Rubisco LSMT and SET7/9 explain why Rubisco LSMT generates multiply methylated Lys, wheras SET7/9 generates only MeLys.	Lysine	46-49	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	91-97
22285752-4	2012	In other cells without adenovirus expression, the C-terminal domain of WTX binds to the DNA-binding domain of p53, enhances its binding to CBP, and increases CBP/p300-mediated acetylation of p53 at Lys 373/382.	Lysine	198-201	APC membrane recruitment protein 1	Homo sapiens	71-74
12819771-5	2003	Differences in hydrogen bonding between the MeLys epsilon-amino group and Rubisco LSMT and SET7/9 explain why Rubisco LSMT generates multiply methylated Lys, wheras SET7/9 generates only MeLys.	Lysine	46-49	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	165-171
22352855-4	2012	It was clear that LDAI selectively labeled a single Lys(K32) in DHFR, proximal to the ligand-binding pocket.	Lysine	52-55	dihydrofolate reductase	Homo sapiens	64-68
825141-3	1976	The lactoferrin preparation obtained was highly purified as judged by polyacrylamide gel electrophoresis under both non-denaturing and denaturing conditions, and the presence of lysine as the only NH2-terminal amino acid.	Lysine	178-184	lactotransferrin	Mus musculus	4-15
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Lysine	9-15	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Lysine	50-53	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Lysine	59-62	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Lysine	59-62	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
12679340-6	2003	The four lysine residues located in the SMG loop, Lys-260, Lys-263, Lys-265, and Lys-268, also play an important role in mediating the sensitivity of OTCase to ornithine and to arginase and appear to be involved in transducing and enhancing the signal given by ornithine for the closure of the catalytic domain.	Lysine	59-62	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	150-156
22803945-8	2012	The most likely candidates to interact with anionic groups of mitochondrial phospholipids are invariant lysine and arginine residues in the environment of the myoglobin heme cavity, which do not change their ionization state in the pH range investigated.	Lysine	104-110	myoglobin	Homo sapiens	159-168
72-4	1975	Polyacrylamide gel electrophoresis of polypeptides released from denatured Sepharose-Myosin indicates that 85% of the myosin is attached to the agarose beads through the heavy chains and the remainder through the light chains, in agreement with predictions of binding and release based upon either the lysine contents or molecular weights of themyosin subunits.	Lysine	302-308	myosin heavy chain 14	Homo sapiens	85-91
22135382-9	2012	In addition, acetylation of histone H3 [lysine (Lys9)-acetylated histone H3 (AcK9-H3)] on the promoter region of MIP-2 and CXCR2 was increased in the injured SCN after PSL.	Lysine	40-46	C-X-C motif chemokine ligand 2	Homo sapiens	113-118
12652484-3	2003	ELPs with repeating sequences of [(VPGVG)(2)(VPGKG)(VPGVG)(2)](21) were synthesized and the free amino groups on the lysine residues were modified by reacting with imidazole-2-carboxyaldehyde to incorporate the metal-binding ligands into the ELP bio- polymers.	Lysine	117-123	nuclear receptor subfamily 5 group A member 1	Homo sapiens	0-3
72-4	1975	Polyacrylamide gel electrophoresis of polypeptides released from denatured Sepharose-Myosin indicates that 85% of the myosin is attached to the agarose beads through the heavy chains and the remainder through the light chains, in agreement with predictions of binding and release based upon either the lysine contents or molecular weights of themyosin subunits.	Lysine	302-308	myosin heavy chain 14	Homo sapiens	118-124
124728-5	1975	The kinetic constant of trinitrophenylation of the epsilon-amino group of lysine at the active site was found to be 2000 S-1-M-1, whereas a much smaller constant of 2.2 S-1-M-1 was obtained for the trinitrophenylation of the unessential lysyl residues of myosin.	Lysine	74-80	myosin heavy chain 14	Homo sapiens	255-261
12805403-7	2003	Endostatin-mediated stimulation of plasminogen activation, vitronectin degradation, and endothelial cell detachment is inhibited by carboxypeptidase B, indicating an essential role for carboxyl-terminal lysines.	Lysine	203-210	collagen type XVIII alpha 1 chain	Homo sapiens	0-10
22116596-5	2012	The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients.	Lysine	59-62	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	51-54
22252316-1	2012	Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation.	Lysine	25-31	H2B clustered histone 21	Homo sapiens	18-21
12615929-3	2003	Mutational analyses identified two major sumoylation sites (Lys(123) and Lys(418)) in SREBP-1a and a single site (Lys(464)) in SREBP-2.	Lysine	60-63	sterol regulatory element binding transcription factor 1	Homo sapiens	86-94
4808708-5	1974	A decrease in lysine-derived aldehyde levels was found in both skin collagen and aortic elastin similar to that found in lathyritic tissue.	Lysine	14-20	elastin	Mus musculus	88-95
12615929-3	2003	Mutational analyses identified two major sumoylation sites (Lys(123) and Lys(418)) in SREBP-1a and a single site (Lys(464)) in SREBP-2.	Lysine	73-76	sterol regulatory element binding transcription factor 1	Homo sapiens	86-94
12615929-3	2003	Mutational analyses identified two major sumoylation sites (Lys(123) and Lys(418)) in SREBP-1a and a single site (Lys(464)) in SREBP-2.	Lysine	73-76	sterol regulatory element binding transcription factor 1	Homo sapiens	86-94
22586912-9	2012	The modeling analysis of the three dimensional structure elucidated that Lys-173 and Asp-202, which were oriented near the hydroxyl group of the substrate, were essential residues for the ProDH activity.	Lysine	73-76	proline dehydrogenase 1	Homo sapiens	188-193
4361686-2	1973	The 4-nitrobenzo-2-oxa-1,3-diazole derivative of lysine 13 of horse cytochrome c and the bis-phenylglyoxal derivative of arginine 13 of Candida krusei cytochrome c have the opposite properties, in that they are readily reduced by the succinate-cytochrome c reductase (EC 1.3.99.1) system but are defective in their capability of transferring electrons to cytochrome c oxidase (EC 1.9.3.1).	Lysine	49-55	cytochrome c, somatic	Equus caballus	68-80
22343720-0	2012	Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.	Lysine	18-25	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	47-51
22343720-2	2012	Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast.	Lysine	102-108	S-adenosylmethionine-dependent methyltransferase	Saccharomyces cerevisiae S288C	17-21
12556442-5	2003	Kinetic and structural considerations suggest that Phe-122 and Lys-114 act cooperatively through non-ionic interactions to promote P-helix formation and ATIII binding to the pentasaccharide.	Lysine	63-66	serpin family C member 1	Homo sapiens	153-158
33617987-1	2021	KAT8 is a lysine acetyltransferase (KAT) that plays a role in a variety of cellular functions ranging from DNA damage repair to apoptosis.	Lysine	10-16	K(lysine) acetyltransferase 8	Mus musculus	0-4
12707784-9	2003	The lysine-substituted mutant was not an in vitro substrate for the yeast protein methyltransferase, Hmt1p/Rmt1.	Lysine	4-10	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	107-111
12641448-1	2003	The small ubiquitin-like modifier SUMO-1 is covalently attached to lysine residues on target proteins by a specific conjugation pathway involving the E1 enzyme SAE1/SAE2 and the E2 enzyme Ubc9.	Lysine	67-73	ubiquitin like modifier activating enzyme 2	Homo sapiens	165-169
12641448-2	2003	In an ATP-dependent manner, the C-terminus of SUMO-1 forms consecutive thiolester bonds with cysteine residues in the SAE2 subunit and Ubc9, before the Ubc9.SUMO-1 thiolester complex catalyzes the formation of an isopeptide bond between SUMO-1 and the epsilon-amino group of the target lysine residue on the protein substrate.	Lysine	286-292	ubiquitin like modifier activating enzyme 2	Homo sapiens	118-122
22374677-2	2012	We recently demonstrated that BubR1 was modified by sumoylation, and that lysine 250 (K250) functions as the crucial site for this modification.	Lysine	74-80	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	30-35
34048738-4	2021	Herein, a novel organic compound (PLC) was designed by using lysine as a bridge to connect two functional small molecules, a hypoxia-responsive nitroimidazole derivative (pimonidazole) and a pH-responsive cinnamaldehyde (CA) derivative.	Lysine	61-67	heparan sulfate proteoglycan 2	Homo sapiens	34-37
22194612-7	2012	These data demonstrate that SUMO and ubiquitin modification of SHMT1 occurs on the same lysine residue and determine the localization and accumulation of SHMT1 in the nucleus.	Lysine	88-94	serine hydroxymethyltransferase 1	Homo sapiens	63-68
22194612-7	2012	These data demonstrate that SUMO and ubiquitin modification of SHMT1 occurs on the same lysine residue and determine the localization and accumulation of SHMT1 in the nucleus.	Lysine	88-94	serine hydroxymethyltransferase 1	Homo sapiens	154-159
12628246-5	2003	Acetylation of the lysine residue in the second AT-hook, which corresponds to Lys65 of HMGA1, has little effect on the DNA binding; so it appears that repression of the hIFNbeta gene, which follows this modification, is not a direct result of the abrogation of DNA binding.	Lysine	19-25	high mobility group AT-hook 1	Homo sapiens	87-92
12615683-3	2003	METHODS AND RESULTS: Alignment of the human apoB4330-4397 sequence with mouse apoB, which also noncovalently binds apo(a), revealed stretches of similar sequence, including a lysine-rich sequence spanning apoB amino acids 4372-4392.	Lysine	175-181	apolipoprotein B	Mus musculus	44-48
12615683-3	2003	METHODS AND RESULTS: Alignment of the human apoB4330-4397 sequence with mouse apoB, which also noncovalently binds apo(a), revealed stretches of similar sequence, including a lysine-rich sequence spanning apoB amino acids 4372-4392.	Lysine	175-181	apolipoprotein B	Mus musculus	78-82
22004688-4	2012	Intriguingly, PABP1 contains glutamate and aspartate methylations, modifications of unknown function in eukaryotes, as well as lysine and arginine methylations, and lysine acetylations.	Lysine	165-171	poly(A) binding protein cytoplasmic 1	Homo sapiens	14-19
22004688-6	2012	Two lysine residues were differentially acetylated or methylated, revealing that PABP1 may be the first example of a cytoplasmic protein utilizing a "methylation/acetylation switch".	Lysine	4-10	poly(A) binding protein cytoplasmic 1	Homo sapiens	81-86
34020723-4	2021	Two recent studies reported reduced immunostaining for trimethylation at lysine 27 on histone H3 (H3K27me3) in IDH Mut 1p/19q codeleted oligodendroglioma.	Lysine	73-79	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	111-114
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	CDK2 associated cullin domain 1	Homo sapiens	172-178
22004789-3	2012	NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.	Lysine	248-254	CDK2 associated cullin domain 1	Homo sapiens	266-272
22159227-4	2012	We identify the lysine residues 120/125 of the E2F1 protein as the prime target sites of Tip60 and show that acetylation at these sites promotes the accumulation of E2F1.	Lysine	16-22	E2F transcription factor 1	Homo sapiens	47-51
22159227-4	2012	We identify the lysine residues 120/125 of the E2F1 protein as the prime target sites of Tip60 and show that acetylation at these sites promotes the accumulation of E2F1.	Lysine	16-22	E2F transcription factor 1	Homo sapiens	165-169
12547786-5	2003	These domains interface at the reactive lysine, Lys84, where trinitrophenylation (TNP-Lys84-S1) was observed in this work to block actin activation of myosin ATPase and in vitro sliding of actin over myosin.	Lysine	40-46	myosin heavy chain 14	Homo sapiens	151-157
12547786-5	2003	These domains interface at the reactive lysine, Lys84, where trinitrophenylation (TNP-Lys84-S1) was observed in this work to block actin activation of myosin ATPase and in vitro sliding of actin over myosin.	Lysine	40-46	myosin heavy chain 14	Homo sapiens	200-206
33545070-4	2021	Notably, the positively charged lysine-arginine (KR) clusters are responsible for modulating HMGA1a conformation via electrostatic interaction with the phosphorylated acidic tail.	Lysine	32-38	high mobility group AT-hook 1	Homo sapiens	93-99
12620231-3	2003	SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo.	Lysine	19-25	sirtuin 2	Homo sapiens	0-5
12620231-3	2003	SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo.	Lysine	19-25	tubulin alpha 1b	Homo sapiens	32-45
22072291-1	2012	In Drosophila, males absent on the first (MOF) acetylates histone H4 at lysine 16 (H4K16ac).	Lysine	72-78	males absent on the first	Drosophila melanogaster	42-45
33893171-6	2021	Through mass spectrum and biochemical analysis, we identified lysine 565 and lysine 687 as theK63-linked polyubiquitination sites of NLRP3.	Lysine	62-68	NLR family, pyrin domain containing 3	Mus musculus	133-138
21811308-7	2012	In small-cell lung carcinoma cell lines with low levels of CT47 transcripts, we observed reduced levels of histone 3 lysine 9 trimethylation (H3K9me3) and trimethylated lysine 27 of histone H3 (H3K27me3) without concomitant increase in euchromatic histone modifications.	Lysine	117-123	cancer/testis antigen family 47 member A10	Homo sapiens	59-63
21811308-7	2012	In small-cell lung carcinoma cell lines with low levels of CT47 transcripts, we observed reduced levels of histone 3 lysine 9 trimethylation (H3K9me3) and trimethylated lysine 27 of histone H3 (H3K27me3) without concomitant increase in euchromatic histone modifications.	Lysine	169-175	cancer/testis antigen family 47 member A10	Homo sapiens	59-63
22142192-5	2012	BmHP1s formed homo- and hetero-dimers and interacted with BmSu(var)3-9, which is a methyltransferase for histone H3 lysine 9 (H3K9).	Lysine	116-122	H3K9 methyltransferase-like	Bombyx mori	58-70
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	153-156	mutL homolog 1	Homo sapiens	74-78
33893171-6	2021	Through mass spectrum and biochemical analysis, we identified lysine 565 and lysine 687 as theK63-linked polyubiquitination sites of NLRP3.	Lysine	77-83	NLR family, pyrin domain containing 3	Mus musculus	133-138
12501186-3	2002	MUR1 is a member of the nucleoside-diphosphosugar modifying subclass of the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr, and Ser/Thr residues.	Lysine	191-194	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	0-4
33756345-5	2021	Two of these PTMs, phosphorylation of Serine 694 and Acetylation of Lysine 623 are located in the conserved HIC1 C-terminal region located downstream of the Zinc Finger DNA-binding domain.	Lysine	68-74	HIC ZBTB transcriptional repressor 1	Homo sapiens	108-112
12393902-7	2002	This study also suggests that ubiquitination of Mdm2 and MdmX may not serve as a signal for degradation, as we show that each are capable of synthesizing non-lysine 48 polyubiquitin chains and, in fact, utilize multiple lysine linkages.	Lysine	158-164	MDM4 regulator of p53	Homo sapiens	57-61
12393902-7	2002	This study also suggests that ubiquitination of Mdm2 and MdmX may not serve as a signal for degradation, as we show that each are capable of synthesizing non-lysine 48 polyubiquitin chains and, in fact, utilize multiple lysine linkages.	Lysine	220-226	MDM4 regulator of p53	Homo sapiens	57-61
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	115-121	hexokinase 2	Saccharomyces cerevisiae S288C	22-26
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	115-121	hexokinase 2	Saccharomyces cerevisiae S288C	61-65
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	115-121	karyopherin alpha	Saccharomyces cerevisiae S288C	71-76
33986438-2	2021	Here we show that the master transcription factor OCT4 in pluripotent stem cells (PSCs) was methylated at multiple lysine residues.	Lysine	115-121	POU class 5 homeobox 1	Homo sapiens	50-54
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	180-186	hexokinase 2	Saccharomyces cerevisiae S288C	22-26
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	180-186	hexokinase 2	Saccharomyces cerevisiae S288C	61-65
22157003-5	2012	We also show that the Hxk2 nuclear import and the binding of Hxk2 with Kap60 are glucose-dependent and involve one lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.	Lysine	180-186	karyopherin alpha	Saccharomyces cerevisiae S288C	71-76
12438576-5	2002	BZLF1-expressing cells had increased p53-specific DNA binding activity in electrophoretic mobility shift assays, increased p53 phosphorylation at multiple residues (including serines 6, 9, 15, 33, 46, 315, and 392), and increased acetylation at lysine 320 and lysine 382.	Lysine	245-251	protein Zta	Human gammaherpesvirus 4	0-5
12438576-5	2002	BZLF1-expressing cells had increased p53-specific DNA binding activity in electrophoretic mobility shift assays, increased p53 phosphorylation at multiple residues (including serines 6, 9, 15, 33, 46, 315, and 392), and increased acetylation at lysine 320 and lysine 382.	Lysine	260-266	protein Zta	Human gammaherpesvirus 4	0-5
33986438-3	2021	LSD1 that is highly expressed in PSCs can directly interact with and demethylate OCT4 at lysine 222 (K222) in the flexible linker region.	Lysine	89-95	POU class 5 homeobox 1	Homo sapiens	81-85
12354770-5	2002	Here, we report that ARNT is modified by SUMO-1 chiefly at Lys(245) within the PAS domain of this protein, both in vivo and in vitro.	Lysine	59-62	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	21-25
22241783-0	2012	Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.	Lysine	27-33	SET and MYND domain containing 2	Homo sapiens	0-5
22241783-0	2012	Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.	Lysine	27-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	49-54
33986438-5	2021	Furthermore, site-specifically replacing K222 with phenylalanine to mimic the constitutively methylated lysine promoted the "locked-in" mode engagement of the OCT4 PORE-homodimers that tightly bind to and block the transcription of multiple PORE-motif-containing target genes regulating cell fate determination and cell junction organization, and thereby reducing the pluripotency of PSCs.	Lysine	104-110	POU class 5 homeobox 1	Homo sapiens	159-163
12354770-6	2002	Substitution of the target lysine with alanine enhanced the transcriptional potential of ARNT per se.	Lysine	27-33	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	89-93
33986537-2	2021	The localization of de novo DNA methyltransferase DNMT3A is facilitated by its PWWP domain recognizing histone H3 lysine 36 (H3K36) methylation1,2 and is normally depleted at CpG islands (CGIs)3.	Lysine	114-120	DNA methyltransferase 3 alpha	Homo sapiens	50-56
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Lysine	287-293	p38a MAP kinase	Drosophila melanogaster	323-330
33986537-5	2021	DNMT3A PWWP mutants accumulate at regions containing PRC1-mediated formation of monoubiquitylated histone H2A lysine 119 (H2AK119ub), irrespective of the amounts of PRC2-catalyzed formation of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	110-116	DNA methyltransferase 3 alpha	Homo sapiens	0-6
33986537-5	2021	DNMT3A PWWP mutants accumulate at regions containing PRC1-mediated formation of monoubiquitylated histone H2A lysine 119 (H2AK119ub), irrespective of the amounts of PRC2-catalyzed formation of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	218-224	DNA methyltransferase 3 alpha	Homo sapiens	0-6
12397363-6	2002	Transcriptional activation by Ash1 coincides with methylation of these three lysine residues at the promoter of Ash1 target genes.	Lysine	77-83	absent, small, or homeotic discs 1	Drosophila melanogaster	30-34
33975961-5	2021	A ubiquitination assay showed that lysine-155 of TRAF3 was the critical residue for K33-linked polyubiquitination, which contributes to the formation of a TRAF3-TBK1 complex.	Lysine	35-41	TANK binding kinase 1	Homo sapiens	161-165
12397363-6	2002	Transcriptional activation by Ash1 coincides with methylation of these three lysine residues at the promoter of Ash1 target genes.	Lysine	77-83	absent, small, or homeotic discs 1	Drosophila melanogaster	112-116
12060666-3	2002	In this work, we demonstrate that lysine residues 239, 731, and 788 of GRIP1 serve as principal attachment sites for SUMO-1.	Lysine	34-40	glutamate receptor interacting protein 1	Homo sapiens	71-76
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Lysine	0-3	glutamate receptor interacting protein 1	Homo sapiens	127-132
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Lysine	12-15	glutamate receptor interacting protein 1	Homo sapiens	127-132
12060666-5	2002	Likewise, Lys-731 and Lys-788 mutants of GRIP1 have attenuated ability to enhance AR-dependent transcription and fail to synergize with PIASx beta-mediated activation of AR function, indicating that sumoylation modifies the ability of GRIP1 to function as a steroid receptor coactivator.	Lysine	10-13	glutamate receptor interacting protein 1	Homo sapiens	41-46
21967556-1	2012	Identification of Hb A2-Melbourne [delta43(CD2)Glu Lys] in Thai individuals.	Lysine	51-54	CD2 molecule	Homo sapiens	43-46
22694102-3	2012	Unfortunately, SIRT2 complex structure is not available yet, hence molecular docking was carried out to dock the substrate (NAD(+) and acetylated lysine) and inhibitor (sirtinol) in the NAD(+) binding site.	Lysine	146-152	sirtuin 2	Homo sapiens	15-20
33975961-6	2021	Subsequently, we revealed that VP3 blocked TRAF3-TBK1 complex formation through reducing K33-linked polyubiquitination of lysine-155 on TRAF3.	Lysine	122-128	TANK binding kinase 1	Homo sapiens	49-53
33975961-9	2021	In this study, we first identified that K33-linked polyubiquitination of lysine-155 of TRAF3 enhances the interaction with TBK1, which positively regulates the host IFN immune response.	Lysine	73-79	TANK binding kinase 1	Homo sapiens	123-127
12016229-4	2002	Recent kinetic studies indicate that potassium functionally compensates for the absence of the second lysine in the human tyrosyl-tRNA synthetase (222KKSSS226).	Lysine	102-108	tyrosyl-tRNA synthetase 1	Homo sapiens	122-145
33975961-10	2021	Meanwhile, we discovered that the interaction of the CC1 domain of the Avibirnavirus VP3 protein and the residue lysine-155 of TRAF3 reduced the K33-linked polyubiquitination of TRAF3 and blocked the formation of the TRAF3-TBK1 complex, which contributed to the downregulation of host IFN signaling, supporting viral replication.	Lysine	113-119	TANK binding kinase 1	Homo sapiens	223-227
33964139-8	2022	The amino acids Lys154, Lys 180, and Lys220 of the p32 protein were identified as putative ubiquitination sites.	Lysine	16-19	complement component 1, q subcomponent binding protein	Mus musculus	51-54
12151350-6	2002	The XPD 751 Lys allele (combined Lys/Lys and Lys/Gln genotypes) was associated with a significantly increased risk of lung cancer (OR = 3.19; CI 1.01-10.07).	Lysine	12-15	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
12151350-6	2002	The XPD 751 Lys allele (combined Lys/Lys and Lys/Gln genotypes) was associated with a significantly increased risk of lung cancer (OR = 3.19; CI 1.01-10.07).	Lysine	33-36	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
12151350-6	2002	The XPD 751 Lys allele (combined Lys/Lys and Lys/Gln genotypes) was associated with a significantly increased risk of lung cancer (OR = 3.19; CI 1.01-10.07).	Lysine	33-36	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
23071455-6	2012	Furthermore, real-time interaction analyses demonstrate that CortoCD binds with high affinity RPL12 tri-methylated on lysine 3.	Lysine	118-124	Ribosomal protein L12	Drosophila melanogaster	94-99
33744765-3	2021	In this study, we demonstrate that the first lysine residue in the reported K66KAE SUMOylation motif in HMGA2 can be methylated in vitro and in vivo by the Set7/9 methyltransferase.	Lysine	45-51	high mobility group AT-hook 2	Homo sapiens	104-109
23209641-2	2012	Here we demonstrate for the first time that LH3 also modifies the lysine residues in the collagenous domain of adiponectin, which has important roles in glucose and lipid metabolism and inflammation.	Lysine	66-72	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	44-47
23209641-2	2012	Here we demonstrate for the first time that LH3 also modifies the lysine residues in the collagenous domain of adiponectin, which has important roles in glucose and lipid metabolism and inflammation.	Lysine	66-72	adiponectin, C1Q and collagen domain containing	Mus musculus	111-122
23209641-3	2012	Hydroxylation and, especially, glycosylation of the lysine residues of adiponectin have been shown to be essential for the formation of the more active high molecular weight adiponectin oligomers and thus for its function.	Lysine	52-58	adiponectin, C1Q and collagen domain containing	Mus musculus	71-82
23209641-3	2012	Hydroxylation and, especially, glycosylation of the lysine residues of adiponectin have been shown to be essential for the formation of the more active high molecular weight adiponectin oligomers and thus for its function.	Lysine	52-58	adiponectin, C1Q and collagen domain containing	Mus musculus	174-185
12130695-5	2002	Substitutions of the amino acids at the putative local anesthetic binding site (i.e., F1760, N1765, Y1767, and N406) with lysine had much lesser effects on prenylamine block of the mutant hNav1.5 channels compared with local anesthetic block.	Lysine	122-128	sodium voltage-gated channel alpha subunit 5	Homo sapiens	188-195
33961407-6	2021	For comparison, random lysine conjugation analogs with an average of one polymer per Fab were prepared by bis-aryl hydrazone conjugation.	Lysine	23-29	FA complementation group B	Homo sapiens	85-88
11986303-2	2002	Peroxiredoxin (Prx) I is a member of the peroxiredoxin family of peroxidases and contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin-dependent kinases (CDKs).	Lysine	124-127	cyclin dependent kinase 1	Homo sapiens	178-182
23209641-5	2012	Circulating adiponectin levels in mutant mice lacking the lysyl hydroxylase activity of LH3 were significantly reduced, which indicates that LH3 is required for complete modification of lysine residues in adiponectin and the loss of some of the glycosylated hydroxylysine residues severely affects the secretion of adiponectin.	Lysine	186-192	adiponectin, C1Q and collagen domain containing	Mus musculus	12-23
23209641-5	2012	Circulating adiponectin levels in mutant mice lacking the lysyl hydroxylase activity of LH3 were significantly reduced, which indicates that LH3 is required for complete modification of lysine residues in adiponectin and the loss of some of the glycosylated hydroxylysine residues severely affects the secretion of adiponectin.	Lysine	186-192	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	88-91
23209641-5	2012	Circulating adiponectin levels in mutant mice lacking the lysyl hydroxylase activity of LH3 were significantly reduced, which indicates that LH3 is required for complete modification of lysine residues in adiponectin and the loss of some of the glycosylated hydroxylysine residues severely affects the secretion of adiponectin.	Lysine	186-192	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	141-144
33962636-6	2021	However, the methylation signature on Tau lysine changes once it acquires pathological aggregated form.	Lysine	42-48	microtubule associated protein tau	Homo sapiens	38-41
12077605-4	2002	Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methylation of histone H3 at lysine 4 (Lys 4) through ubiquitination of H2B at Lys 123 in yeast (Saccharomyces cerevisiae).	Lysine	111-114	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	51-55
12077605-4	2002	Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methylation of histone H3 at lysine 4 (Lys 4) through ubiquitination of H2B at Lys 123 in yeast (Saccharomyces cerevisiae).	Lysine	111-114	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	57-61
12077605-4	2002	Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methylation of histone H3 at lysine 4 (Lys 4) through ubiquitination of H2B at Lys 123 in yeast (Saccharomyces cerevisiae).	Lysine	111-114	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	101-109
12077605-6	2002	These data indicate a unidirectional regulatory pathway in which ubiquitination of H2B (Lys 123) is a prerequisite for H3 (Lys 4) methylation.	Lysine	88-91	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	123-128
12077605-7	2002	We also show that an H2B-K123R mutation perturbs silencing at the telomere, providing functional links between Rad6-mediated H2B (Lys 123) ubiquitination, Set1-mediated H3 (Lys 4) methylation, and transcriptional silencing.	Lysine	130-133	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	111-115
22563434-4	2012	Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2).	Lysine	36-42	class II major histocompatibility complex transactivator	Homo sapiens	184-189
33962636-10	2021	Here, we have discussed the effect of methylation on Tau function in a site-specific manner and their cross-talk with other lysine modifications.	Lysine	124-130	microtubule associated protein tau	Homo sapiens	53-56
33394042-3	2021	The SUMOylation on alpha-tubulin mainly occurred at Lys 96 (K96), K166, and K304 of soluble alpha-tubulin and could be removed by SUMO-specific peptidase 1.	Lysine	52-55	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	144-155
12123582-4	2002	Here, we report that lysine 79 (K79) of H3, located in the globular domain, can be methylated.	Lysine	21-27	keratin 79	Homo sapiens	32-35
11919183-6	2002	We report that Lys-199, Phe-201, and Phe-251 are essential for cell viability and required for Sis1 polypeptide binding activity.	Lysine	15-18	type II HSP40 co-chaperone SIS1	Saccharomyces cerevisiae S288C	95-99
33979575-0	2021	Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.	Lysine	29-35	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	42-46
11919190-9	2002	However, TGF-beta induced rapid and prolonged lysine acetylation of Ets1.	Lysine	46-52	ETS proto-oncogene 1, transcription factor	Homo sapiens	68-72
22539995-7	2012	PIAS1 promoted SUMO-1 modification of GATA4 on lysine 366.	Lysine	47-53	protein inhibitor of activated STAT 1	Homo sapiens	0-5
33979575-3	2021	Here, we show that histone H3 lysine 37 mono-methylation (H3K37me1) is catalyzed by Set1p and Set2p and that it regulates replication origin licensing.	Lysine	30-36	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	84-89
12084512-1	2002	Our previous studies revealed that the 143-148 fragment of interleukin-1 receptor antagonist (IL-1 Ra) molecule with a Val-Thr-Lys-Phe-Tyr-Phe (VTKFYF) sequence inhibits the interleukin-1 (IL-1) interaction with its cellular receptor.	Lysine	127-130	interleukin 1 receptor antagonist	Homo sapiens	59-92
33935047-2	2021	The aim of this study was to investigate alteration of cationic amino acid transporter (CAT-1) activity in the transport of lysine and the pretreatment effect of lysine on pro-inflammatory states in an amyotrophic lateral sclerosis cell line.	Lysine	124-130	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	88-93
12084512-1	2002	Our previous studies revealed that the 143-148 fragment of interleukin-1 receptor antagonist (IL-1 Ra) molecule with a Val-Thr-Lys-Phe-Tyr-Phe (VTKFYF) sequence inhibits the interleukin-1 (IL-1) interaction with its cellular receptor.	Lysine	127-130	interleukin 1 receptor antagonist	Homo sapiens	94-101
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	30-33	ATM serine/threonine kinase	Homo sapiens	157-160
22169038-5	2011	SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHLH2 on lysine 49 to increase its activation of the MAO-A promoter.	Lysine	85-91	nescient helix-loop-helix 2	Homo sapiens	76-81
22169038-5	2011	SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHLH2 on lysine 49 to increase its activation of the MAO-A promoter.	Lysine	85-91	monoamine oxidase A	Homo sapiens	129-134
22030396-6	2011	Uncoupling FKBP38 from Hsp90 by substituting a conserved lysine in the TPR domain modestly enhances CFTR maturation and further reduces its synthesis.	Lysine	57-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	23-28
11875057-5	2002	p53 C-terminal acetylation at Lys(320) and Lys(382), which may stabilize p53 and activate sequence-specific DNA binding, required Ser(15) phosphorylation by ATM and was enhanced by phosphorylation at nearby residues including Ser(6), Ser(9), and Thr(18).	Lysine	43-46	ATM serine/threonine kinase	Homo sapiens	157-160
33935047-3	2021	The mRNA expression of cationic amino acid transporter 1 was lower in NSC-34/hSOD1G93A (MT) than the control cell line (WT), lysine transport is mediated by CAT-1 in NSC-34 cell lines.	Lysine	125-131	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	23-56
33935047-3	2021	The mRNA expression of cationic amino acid transporter 1 was lower in NSC-34/hSOD1G93A (MT) than the control cell line (WT), lysine transport is mediated by CAT-1 in NSC-34 cell lines.	Lysine	125-131	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	157-162
33935047-4	2021	The uptake of [3H]L-lysine was Na+-independent, voltage-sensitive, and strongly inhibited by inhibitors and substrates of cationic amino acid transporter 1 (system y+).	Lysine	18-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	122-155
21787888-7	2011	On the other hand, no arginine or lysine residues are found in the active site of MMP-7.	Lysine	34-40	matrix metallopeptidase 7	Homo sapiens	82-87
33755722-4	2021	At the molecular level, DEK recruits the corepressor NCoR1 to repress acetylation of histone 3 at lysine 27 (H3K27ac) and restricts the chromatin accessibility of HSCs, governing the expression of quiescence-associated genes (e.g., Akt1/2, Ccnb2, and p21).	Lysine	98-104	DEK proto-oncogene	Homo sapiens	24-27
11850414-3	2002	Both modifications lead to the binding of specific proteins; bromodomain proteins, such as GCN5, bind acetyl lysines and the chromodomain protein, HP1, binds methyl lysine 9 of histone H3.	Lysine	109-115	chromobox 5	Homo sapiens	147-150
33755722-4	2021	At the molecular level, DEK recruits the corepressor NCoR1 to repress acetylation of histone 3 at lysine 27 (H3K27ac) and restricts the chromatin accessibility of HSCs, governing the expression of quiescence-associated genes (e.g., Akt1/2, Ccnb2, and p21).	Lysine	98-104	nuclear receptor corepressor 1	Homo sapiens	53-58
11985881-2	2002	In this region, nucleotide transition of the plasma membrane Ca2+-ATPase isoform 2 (PMCA2) gene was found, which caused a glutamic acid to change into lysine.	Lysine	151-157	ATPase, Ca++ transporting, plasma membrane 2	Mus musculus	45-82
22007908-6	2011	Previous studies showed that the stability of endogenous DNMT1 protein is regulated by lysine methylation through histone lysine methyltransferase Set7 and lysine-specific demethylase 1 (LSD1), with the methylated DNMT1 being the target for proteasomal degradation.	Lysine	87-93	KMT5A pseudogene 1	Homo sapiens	147-151
33755722-4	2021	At the molecular level, DEK recruits the corepressor NCoR1 to repress acetylation of histone 3 at lysine 27 (H3K27ac) and restricts the chromatin accessibility of HSCs, governing the expression of quiescence-associated genes (e.g., Akt1/2, Ccnb2, and p21).	Lysine	98-104	H3 histone pseudogene 16	Homo sapiens	251-254
21880715-10	2011	Meanwhile, mutation of EDEE residues impairs both the binding and the enzymatic activity of SMYD2 to p53 Lys-370.	Lysine	105-108	SET and MYND domain containing 2	Homo sapiens	92-97
21880715-11	2011	These data together reveal the molecular basis of SMYD2 in specifically recognizing and regulating functions of p53 tumor suppressor through Lys-370 monomethylation.	Lysine	141-144	SET and MYND domain containing 2	Homo sapiens	50-55
11985881-2	2002	In this region, nucleotide transition of the plasma membrane Ca2+-ATPase isoform 2 (PMCA2) gene was found, which caused a glutamic acid to change into lysine.	Lysine	151-157	ATPase, Ca++ transporting, plasma membrane 2	Mus musculus	84-89
11781309-7	2002	Modeling studies suggest that serine palmitoyltransferase is likely to have a single active site that lies at the Lcb1p small middle dotLcb2p interface and that the mutations in Lcb1p reside near the lysine in Lcb2p that is expected to form the Schiff"s base with the pyridoxal 5"-phosphate cofactor.	Lysine	200-206	serine C-palmitoyltransferase LCB1	Saccharomyces cerevisiae S288C	178-183
33544437-1	2021	The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of histone H4 at lysine 16 (H4K16) and some non-histone proteins.	Lysine	96-102	H4 clustered histone 6	Homo sapiens	82-92
11773077-3	2002	We show that yeast Ada2, Ada3, and Gcn5 form a catalytic core of the ADA and Spt-Ada-Gcn5-acetyltransferase HAT complexes, which is necessary and sufficient in vitro for nucleosomal HAT activity and lysine specificity of the intact HAT complexes.	Lysine	199-205	histone acetyltransferase NGG1	Saccharomyces cerevisiae S288C	25-29
11773077-5	2002	Our results suggest that Ada2 potentiates the Gcn5 catalytic activity and that Ada3 facilitates nucleosomal acetylation and an expanded lysine specificity.	Lysine	136-142	histone acetyltransferase NGG1	Saccharomyces cerevisiae S288C	79-83
33996800-6	2021	We further demonstrate that ZNRF1 and Casitas B-lineage lymphoma (CBL), another E3 ubiquitin ligase responsible for EGFR ubiquitination, mediate ubiquitination at distinct lysine residues on EGFR.	Lysine	172-178	Cbl proto-oncogene	Homo sapiens	66-69
11805079-5	2002	The formation of the stably cross-linked species with dL depends on the polymerase lysine 72 residue, which forms a Schiff base with the C-1 aldehyde during excision of an unmodified abasic site.	Lysine	83-89	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	137-140
11805079-6	2002	In the case of a dL residue, attack on the lactone C-1 by lysine 72 proceeds more slowly and evidently produces an amide linkage, which resists further processing.	Lysine	58-64	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	51-54
21896569-6	2011	To investigate whether Mt-Acs is regulated by lysine acetylation as reported for Salmonella enterica Acs, its mutant K617R was also generated.	Lysine	46-52	acetyl-CoAsynthetase	Mycobacterium tuberculosis H37Rv	26-29
33877835-6	2021	Further, the TCPD analysis, which relies on a combination of experimental data, shows that the free energy of hydration of Arg+ is less favorable than that of Lys+.	Lysine	159-162	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	123-126
21435399-2	2011	Recently, a novel pyridoxal 5"-phosphate (PLP) dependent enzyme called LL-diaminopimelate aminotransferase (LL-DAP-AT) was identified in the lysine biosynthetic pathway of plants and Chlamydiae.	Lysine	141-147	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	71-106
21435399-2	2011	Recently, a novel pyridoxal 5"-phosphate (PLP) dependent enzyme called LL-diaminopimelate aminotransferase (LL-DAP-AT) was identified in the lysine biosynthetic pathway of plants and Chlamydiae.	Lysine	141-147	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	108-117
11882902-0	2002	Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.	Lysine	68-74	chromobox 5	Homo sapiens	17-20
11882902-2	2002	Methylation of lysine 9 in histone H3 is recognized by heterochromatin protein 1 (HP1), which directs the binding of other proteins to control chromatin structure and gene expression.	Lysine	15-21	chromobox 5	Homo sapiens	55-80
11882902-2	2002	Methylation of lysine 9 in histone H3 is recognized by heterochromatin protein 1 (HP1), which directs the binding of other proteins to control chromatin structure and gene expression.	Lysine	15-21	chromobox 5	Homo sapiens	82-85
33946784-3	2021	DHTKD1 is a gene encoding 2-oxoadipate dehydrogenase (E1a), which functions in the L-lysine degradation pathway.	Lysine	83-91	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	0-6
11882902-3	2002	Here we show that HP1 uses an induced-fit mechanism for recognition of this modification, as revealed by the structure of its chromodomain bound to a histone H3 peptide dimethylated at Nzeta of lysine 9.	Lysine	194-200	chromobox 5	Homo sapiens	18-21
11882290-10	2002	This latter result provides a molecular explanation for the previous identification of MKS1 as LYS80, a negative regulator of lysine biosynthesis [8].	Lysine	126-132	Mks1p	Saccharomyces cerevisiae S288C	87-91
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 5	Mus musculus	4-29
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 5	Mus musculus	31-34
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 5	Mus musculus	51-59
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 5	Mus musculus	84-88
11882290-10	2002	This latter result provides a molecular explanation for the previous identification of MKS1 as LYS80, a negative regulator of lysine biosynthesis [8].	Lysine	126-132	Mks1p	Saccharomyces cerevisiae S288C	95-100
21895798-2	2011	Overexpression of Lys20 resulted in eightfold increased Lys, as well as 2-oxoglutarate pools, which were not attained by overexpressing Lys21 or other pathway enzymes (Lys1, Lys9 or Lys12).	Lysine	18-21	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	182-187
11744707-8	2002	Mutation of lysine 74 in mGluR4, or the analogous lysine in mGluR8, to tyrosine (mimicking mGluR1 at this position) produced a large decrease in binding.	Lysine	50-56	glutamate receptor, metabotropic 8	Mus musculus	60-66
33749253-1	2021	Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the development of aggressive cancers.	Lysine	61-67	MLLT1 super elongation complex subunit	Homo sapiens	39-44
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	TANK binding kinase 1	Homo sapiens	96-100
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	101-105
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	TANK binding kinase 1	Homo sapiens	158-162
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	163-167
11839791-2	2002	We have used in vitro mutagenesis to obtain a temperature-sensitive SSO2 allele, sso2-1, in which a conserved arginine has been changed to a lysine.	Lysine	141-147	syntaxin	Saccharomyces cerevisiae S288C	68-72
11839791-2	2002	We have used in vitro mutagenesis to obtain a temperature-sensitive SSO2 allele, sso2-1, in which a conserved arginine has been changed to a lysine.	Lysine	141-147	syntaxin	Saccharomyces cerevisiae S288C	81-85
33854041-10	2021	Taken together, Sirt1 deacetylates p62 at lysine 295 to disturb Keap1-mediated p62 poly-ubiquitination, thus up-regulating p62 expression to promote hepato-carcinogenesis.	Lysine	42-48	sirtuin 1	Mus musculus	16-21
12658774-6	2002	Urokinase didn"t bind to Ann-II, demonstrating the role of receptor-related lysine residues on activation of PLG, showing that the Ann-II-PLG interaction was dependent upon carboxyl-terminal lysine residues.	Lysine	191-197	annexin A2	Homo sapiens	131-137
33691185-8	2021	SELP-415 K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.	Lysine	91-97	selectin P	Homo sapiens	0-4
11600502-2	2001	To identify the GTP binding site(s) within human GDH, mutant GDHs at Tyr-266 or Lys-450 position were constructed by cassette mutagenesis.	Lysine	80-83	glutamate dehydrogenase 1	Homo sapiens	49-52
11600502-3	2001	More than 90% of the initial activities were remained at the concentration of GTP up to 300 microm for the Lys-450 mutant GDHs regardless of their size, hydrophobicity, and ionization of the side chains, whereas the wild type GDH and the Tyr-266 mutant GDHs were completely inhibited by 30 microm GTP.	Lysine	107-110	glutamate dehydrogenase 1	Homo sapiens	122-125
11600502-7	2001	The results with cassette mutagenesis and photoaffinity labeling demonstrate selectivity of the photoprobe for the GTP binding site and suggest that Lys-450, but not Tyr-266, is required for efficient binding of GTP to GDH.	Lysine	149-152	glutamate dehydrogenase 1	Homo sapiens	219-222
11600502-8	2001	Interestingly, studies of the steady-state velocity showed that both the wild type GDH and the Tyr-266 mutant GDHs were inhibited by ATP at concentrations between 10 and 100 microm, whereas less than 10% of the initial activities of the Lys-450 mutant GDHs were diminished by ATP.	Lysine	237-240	glutamate dehydrogenase 1	Homo sapiens	83-86
21852399-8	2011	The endogenous glial cells, as well as those induced by Gcm overexpression display low levels of histone 3 lysine 9 acetylation (H3K9ac) and Drosophila CREB-binding protein (dCBP) Histone Acetyl-Transferase (HAT).	Lysine	107-113	glial cells missing	Drosophila melanogaster	56-59
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	195-200
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	270-276
21724641-7	2011	Further modeling study of Smyd2 in complex with a p53 peptide indicates that mono-methylation of p53-Lys(372) might result in steric conflict of the methyl group with the surrounding residues of Smyd2, providing a structural explanation for the inhibitory effect of the SET7/9-mediated mono-methylation of p53-Lys(372) on the Smyd2-mediated methylation of p53-Lys(370).	Lysine	310-313	SET and MYND domain containing 2	Homo sapiens	195-200
33631678-2	2021	As cyt c binding to CL-containing membranes is at least partially associated with electrostatic protein/lipid interaction, we screened single-point mutants of horse heart cyt c with various substitutions of lysine at position 72, considered to play a significant role in both the binding and peroxidase activity of the protein.	Lysine	207-213	cytochrome c, somatic	Equus caballus	3-8
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Lysine	12-18	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	86-91
11732899-4	2001	To identify the exact binding site of the probe, the distances between the bound ANN as donor and acceptors in known positions (Lys-553 or Cys-707) of the myosin head were determined by using fluorescence resonance energy transfer.	Lysine	128-131	myosin heavy chain 14	Homo sapiens	155-161
11713475-4	2001	Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged "buttons").	Lysine	187-194	catenin beta 1	Homo sapiens	87-99
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Lysine	12-18	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	125-130
11713475-4	2001	Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged "buttons").	Lysine	187-194	catenin beta 1	Homo sapiens	156-168
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Lysine	12-18	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	125-130
11713475-4	2001	Earlier structural and biochemical studies demonstrated that the central region of the beta-catenin binding domain of Tcf is essential for anchoring Tcf to beta-catenin via two conserved lysines in beta-catenin (called the charged "buttons").	Lysine	187-194	catenin beta 1	Homo sapiens	156-168
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Lysine	239-245	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	86-91
33683887-8	2021	Compared to the normal controls, AD brain showed different Lys accessibility of tau and RNA splicing complexes, which are the hallmarks of AD pathology, as well as proteins involved in transcription, mitochondrial, and synaptic functions.	Lysine	59-62	microtubule associated protein tau	Homo sapiens	80-83
21708940-3	2011	We provide evidence that protein phosphatase 2A (PP2A) is a negative regulator of the phosphorylation, Lys(48)-linked ubiquitination, and degradation of IRAK-1.	Lysine	103-106	protein phosphatase 2 phosphatase activator	Homo sapiens	33-47
21708940-3	2011	We provide evidence that protein phosphatase 2A (PP2A) is a negative regulator of the phosphorylation, Lys(48)-linked ubiquitination, and degradation of IRAK-1.	Lysine	103-106	protein phosphatase 2 phosphatase activator	Homo sapiens	49-53
21708940-5	2011	siRNA against PP2A catalytic subunit (PP2Ac) or treatment with pharmacological inhibitor, okadaic acid, enhanced IRAK-1 Lys(48)-linked ubiquitination and degradation.	Lysine	120-123	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	14-36
11713475-7	2001	These conformations allow different glutamate residues in the central region of Tcf4 to form a salt bridge with the same critical charged button, Lys 312 of beta-catenin.	Lysine	146-149	catenin beta 1	Homo sapiens	157-169
11714270-3	2001	The data suggest that beta(2)GPI anchors to the membrane surface with its hydrophobic loop adjacent to the positively charged lysine rich region in domain V. Subsequently, beta(2)GPI penetrates the membrane interfacial headgroup region as indicated by a restriction of the lipid side chain mobility, but without formation of a nonbilayer lipid phase.	Lysine	126-132	apolipoprotein H	Homo sapiens	22-32
11567021-0	2001	Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding.	Lysine	0-6	serpin family C member 1	Homo sapiens	14-26
33827976-3	2021	Here, we showed that pharmacological inhibition of histone deacetylase 8 (HDAC8), a histone H3 lysine 27 (H3K27)-specific isozyme overexpressed in a variety of human cancers, thwarts HCC tumorigenicity in a T cell-dependent manner.	Lysine	95-101	histone deacetylase 8	Homo sapiens	51-72
11585814-5	2001	Notably, an H4 peptide previously diacetylated on lysines 8 and 16 was a very poor substrate for acetylation by either yeast Hat1p or human HAT-B.	Lysine	50-57	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	125-130
21708940-5	2011	siRNA against PP2A catalytic subunit (PP2Ac) or treatment with pharmacological inhibitor, okadaic acid, enhanced IRAK-1 Lys(48)-linked ubiquitination and degradation.	Lysine	120-123	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	38-43
33827976-3	2021	Here, we showed that pharmacological inhibition of histone deacetylase 8 (HDAC8), a histone H3 lysine 27 (H3K27)-specific isozyme overexpressed in a variety of human cancers, thwarts HCC tumorigenicity in a T cell-dependent manner.	Lysine	95-101	histone deacetylase 8	Homo sapiens	74-79
21654327-0	2011	High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice.	Lysine	101-107	sirtuin 1	Mus musculus	81-90
33421591-5	2021	Notably, ET-1 administration increased spinal glutamate acid decarboxylases (GAD65/67) expression via initiating HDAC5 nuclear exportation and increased the acetylation of histone 3 at lysine 9 (Acetyl-H3K9) in the promotor regions of spinal Gad1 and Gad2 genes.	Lysine	185-191	endothelin 1	Mus musculus	9-13
21654327-0	2011	High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice.	Lysine	101-107	transformation related protein 53, pseudogene	Mus musculus	115-118
21654327-1	2011	Our purpose was to determine if high-fat diet and treatment with a polyphenol regulate the acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch.	Lysine	106-112	transformation related protein 53, pseudogene	Mus musculus	120-123
21654327-1	2011	Our purpose was to determine if high-fat diet and treatment with a polyphenol regulate the acetylation of lysine-382 of p53, the site regulated by sirtuin-1, and apoptosis in the endothelium of the atherosclerotic lesion-prone mouse aortic arch.	Lysine	106-112	sirtuin 1	Mus musculus	147-156
21654327-2	2011	In cultured endothelial cells, 2 atherogenic stimuli, hydrogen peroxide and tumor necrosis factor-alpha, increased the acetylation of p53 lysine-382, and caspase-3 cleavage, an indicator of apoptotic signaling.	Lysine	138-144	transformation related protein 53, pseudogene	Mus musculus	134-137
11689007-6	2001	It is possible that the abrogation of CYP1A1 induction in the combined Lys(554) + Ile(570) variant may reduce susceptibility of the host to the carcinogenic effects of polycyclic aromatic hydrocarbons.	Lysine	71-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-44
11731082-8	2001	Subsequently, when the amino acid composition of CP reacted with AAPH was analyzed, cysteine, tryptophan, methionine, histidine, tyrosine, and lysine residues were particularly sensitive.	Lysine	143-149	ceruloplasmin	Homo sapiens	49-51
21768309-0	2011	SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.	Lysine	33-39	F-box protein 22	Homo sapiens	4-10
33674747-7	2021	We also show that LY6K-AS regulates the levels of histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of kinetochore members.	Lysine	61-67	lymphocyte antigen 6 family member K	Homo sapiens	18-22
21855805-1	2011	Methylation of specific lysine residues in the C terminus of p53 is thought to govern p53-dependent transcription following genotoxic and oncogenic stress.	Lysine	24-30	transformation related protein 53, pseudogene	Mus musculus	61-64
21855805-1	2011	Methylation of specific lysine residues in the C terminus of p53 is thought to govern p53-dependent transcription following genotoxic and oncogenic stress.	Lysine	24-30	transformation related protein 53, pseudogene	Mus musculus	86-89
21855805-2	2011	In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines.	Lysine	70-76	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	15-21
11743865-2	2001	Rhodopsin has an 11-cis retinal as the chromophore, which binds covalently with a lysine residue through a protonated Schiff base linkage.	Lysine	82-88	rhodopsin	Bos taurus	0-9
11601995-4	2001	Seven site-specific point mutants of MDP-1 were produced by modifying the catalytic aspartate, serine, and lysine residues to asparagine or glutamate, alanine, and arginine, respectively.	Lysine	107-113	magnesium dependent phosphatase 1	Homo sapiens	37-42
21855805-2	2011	In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines.	Lysine	70-76	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	23-27
21855806-3	2011	Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash et al., 2008).	Lysine	82-88	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	104-110
33716169-6	2021	OGT and its interaction partners were immunoprecipitated from OGT wild-type, null and hydrogen peroxide treated cell lysates that had been isotopically labeled with light, medium and heavy lysine and arginine (stable isotopic labeling of amino acids in cell culture [SILAC]).	Lysine	189-195	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
21855806-3	2011	Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash et al., 2008).	Lysine	82-88	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	124-129
21855806-3	2011	Originally defined as a critical layer of p53 regulation in human cell lines, p53 lysine methylation by Set7/9 (also called Setd7) was proposed to fulfill a similar function in vivo in the mouse, promoting p53 acetylation, stabilization, and activation upon DNA damage (Kurash et al., 2008).	Lysine	82-88	transformation related protein 53, pseudogene	Mus musculus	78-81
21794016-6	2011	mRNA expressions of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) were lower in cells cultured in low lysine medium.	Lysine	171-177	peroxisome proliferator activated receptor gamma	Sus scrofa	20-68
21794016-6	2011	mRNA expressions of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) were lower in cells cultured in low lysine medium.	Lysine	171-177	peroxisome proliferator activated receptor gamma	Sus scrofa	70-79
11606747-7	2001	APCs expressing mutant H-2K(b) (Lys(227)) molecules that do not bind CD8 were unable to form stable conjugates with these T cells, even at high peptide concentrations.	Lysine	32-35	histocompatibility 2, K1, K region	Mus musculus	23-30
11514574-9	2001	Consistent with a recent report, we show that nuclear localization of CIITA is enhanced by lysine 144, an in vitro target of pCAF-mediated HAT.	Lysine	91-97	class II major histocompatibility complex transactivator	Homo sapiens	70-75
33674555-6	2021	Our findings indicate that RNF8 ubiquitinates RecQL4 protein mainly at the lysine sites of 876, 1048, and 1101, thereby facilitating the dissociation of RecQL4 from DSB sites.	Lysine	75-81	ring finger protein 8	Homo sapiens	27-31
11477073-2	2001	A region of 9 conserved amino acid residues (residues Gln-337 through Lys-345) in the C terminus of human FEN-1 (hFEN-1) was shown to be responsible for the interaction with PCNA.	Lysine	70-73	flap structure-specific endonuclease 1	Homo sapiens	106-111
21794016-8	2011	These results indicate that low lysine concentrations in culture medium inhibit differentiation of 3T3-L1 preadipocytes through inhibiting the mRNA expressions of PPARgamma and C/EBPalpha.	Lysine	32-38	peroxisome proliferator activated receptor gamma	Sus scrofa	163-172
33674555-6	2021	Our findings indicate that RNF8 ubiquitinates RecQL4 protein mainly at the lysine sites of 876, 1048, and 1101, thereby facilitating the dissociation of RecQL4 from DSB sites.	Lysine	75-81	RecQ like helicase 4	Homo sapiens	46-52
33674555-6	2021	Our findings indicate that RNF8 ubiquitinates RecQL4 protein mainly at the lysine sites of 876, 1048, and 1101, thereby facilitating the dissociation of RecQL4 from DSB sites.	Lysine	75-81	RecQ like helicase 4	Homo sapiens	153-159
11432854-2	2001	The conserved lysine in the Walker A motif of the ATP-binding domain encoded by the yeast RFC1, RFC2, RFC3, and RFC4 genes was mutated to glutamic acid.	Lysine	14-20	replication factor C subunit 4	Saccharomyces cerevisiae S288C	112-116
33565245-4	2021	Mechanistically, MITOL mediates ubiquitination of Parkin at lysine 220 residue, which promotes its proteasomal degradation, and thereby fine-tunes mitophagy by controlling the quantity of Parkin.	Lysine	60-66	membrane associated ring-CH-type finger 5	Homo sapiens	17-22
11413542-4	2001	We have focused on the second C2 domain (C2B) of synaptotagmin I, in particular, on a series of conserved lysine residues on beta-strand 4 of C2B.	Lysine	106-112	Synaptotagmin 1	Drosophila melanogaster	49-64
21746811-3	2011	In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (Smu) bearing H3K9me3 (trimethylated histone H3 at lysine 9) in vivo.	Lysine	236-242	chromobox 5	Homo sapiens	109-112
21808242-2	2011	The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).	Lysine	255-258	LIF interleukin 6 family cytokine	Homo sapiens	129-156
11451439-1	2001	Lys-112 and Tyr-113 in pig kidney fructose-1,6-bisphosphatase (FBPase) make direct interactions with AMP in the allosteric binding site.	Lysine	0-3	fructose-bisphosphatase 1	Sus scrofa	34-61
21808242-2	2011	The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).	Lysine	255-258	LIF interleukin 6 family cytokine	Homo sapiens	158-161
11451439-1	2001	Lys-112 and Tyr-113 in pig kidney fructose-1,6-bisphosphatase (FBPase) make direct interactions with AMP in the allosteric binding site.	Lysine	0-3	fructose-bisphosphatase 1	Sus scrofa	63-69
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	91-97	interleukin 17 receptor B	Homo sapiens	15-22
11415439-3	2001	We demonstrate here that CaBP1, similar to PDI and CaBP2, can complement the lethal phenotype of the disrupted Saccharomyces cerevisiae PDI gene, provided that the natural C-terminal Lys-Asp-Glu-Leu sequence is replaced by His-Asp-Glu-Leu.	Lysine	183-186	calcium binding protein 1	Rattus norvegicus	25-30
21904977-1	2011	The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans).	Lysine	68-74	molybdenum cofactor synthesis 3	Homo sapiens	132-137
21904977-1	2011	The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans).	Lysine	68-74	molybdenum cofactor synthesis 3	Homo sapiens	189-193
21904977-1	2011	The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans).	Lysine	68-74	molybdenum cofactor synthesis 3	Homo sapiens	195-200
21746928-6	2011	Specifically, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase, Mof, to the nuclear matrix.	Lysine	49-55	K(lysine) acetyltransferase 8	Mus musculus	166-169
11530934-4	2001	Immunofluorescence microscopy showed that OST48 mutants in which the C-terminal lysine-3 or lysine-5, but not lysine-7, had been replaced by leucine (OST48AK) could be detected on the cell surface.	Lysine	80-86	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	42-47
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	91-97	interleukin 17 receptor B	Homo sapiens	142-149
11530934-4	2001	Immunofluorescence microscopy showed that OST48 mutants in which the C-terminal lysine-3 or lysine-5, but not lysine-7, had been replaced by leucine (OST48AK) could be detected on the cell surface.	Lysine	92-98	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	42-47
11732685-6	2001	Mutation of the 17 lysines in residues 1-220 of the GBP decreased the affinity for gastrin between 1.7- and 3.5-fold and in some cases reduced, but did not abolish, the extent of covalent cross-linking.	Lysine	19-26	gastrin	Homo sapiens	83-90
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	92-95	TNF receptor associated factor 6	Homo sapiens	28-33
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	100-103	TNF receptor associated factor 6	Homo sapiens	28-33
11732685-7	2001	We conclude that one or more lysine residues are involved in binding of gastrin to the GBP, but that no single lysine residue is the preferred target for covalent cross-linking of iodinated gastrin2,17 to the GBP.	Lysine	29-35	gastrin	Homo sapiens	72-79
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	128-134	interleukin 17 receptor B	Homo sapiens	15-22
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	128-134	interleukin 17 receptor B	Homo sapiens	142-149
33658352-7	2021	Consequentially, IL-17RB mutants with substitution at either tyrosine-447 or lysine-470 lose their oncogenic activity.	Lysine	77-83	interleukin 17 receptor B	Homo sapiens	17-24
33647772-4	2021	Thereafter, it was transformed to a full-length Fc-silenced anti-PCSK9 antibody FAP2M21 by fusing to a modified human IgG1 Fc fragment with L234A/L235A/N297G mutations and C-terminal lysine deletion, thus eliminating its immune effector functions and mitigating mAb heterogeneity.	Lysine	183-189	proprotein convertase subtilisin/kexin type 9	Homo sapiens	65-70
11408160-3	2001	Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111.	Lysine	142-149	selectin P	Homo sapiens	172-182
11389722-0	2001	Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase.	Lysine	24-30	glutamate dehydrogenase 1	Homo sapiens	44-67
21454471-5	2011	Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation.	Lysine	100-103	TNF receptor associated factor 6	Homo sapiens	28-33
32970364-4	2021	Ubiquitin ligases RGLG1 and RGLG2 ubiquitinated MAPKKK18 at lysine residue K32 and K154, and promoted its degradation.	Lysine	60-66	RING domain ligase1	Arabidopsis thaliana	18-23
21741597-1	2011	The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene.	Lysine	14-20	lysine methyltransferase 2A	Homo sapiens	138-160
21741597-1	2011	The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene.	Lysine	14-20	lysine methyltransferase 2A	Homo sapiens	162-165
21746851-6	2011	We mapped SUMO acceptor sites in alpha-synuclein and showed that simultaneous mutation of lysines 96 and 102 to arginine significantly impaired alpha-synuclein sumoylation in vitro and in cells.	Lysine	90-97	synuclein alpha	Homo sapiens	33-48
21746851-6	2011	We mapped SUMO acceptor sites in alpha-synuclein and showed that simultaneous mutation of lysines 96 and 102 to arginine significantly impaired alpha-synuclein sumoylation in vitro and in cells.	Lysine	90-97	synuclein alpha	Homo sapiens	144-159
11389722-2	2001	It has been suggested that reactive lysine residue(s) may play an important role in the catalytic activities of glutamate dehydrogenase (GDH).	Lysine	36-42	glutamate dehydrogenase 1	Homo sapiens	112-135
11389722-2	2001	It has been suggested that reactive lysine residue(s) may play an important role in the catalytic activities of glutamate dehydrogenase (GDH).	Lysine	36-42	glutamate dehydrogenase 1	Homo sapiens	137-140
11371211-3	2001	Previously, we demonstrated that anthroyloxy-labeled fatty acid (AOFA) transfer from AFABP to phospholipid membranes occurs by a collisional process, in which ionic interactions between positively charged lysine residues on the protein surface and negatively charged phospholipid headgroups are involved.	Lysine	205-211	fatty acid binding protein 4, adipocyte	Mus musculus	85-90
11371211-4	2001	In the present study, the role of specific lysine residues located in the portal and other regions of AFABP was directly examined using site-directed mutagenesis.	Lysine	43-49	fatty acid binding protein 4, adipocyte	Mus musculus	102-107
11371211-5	2001	The results showed that isoleucine replacement for lysine in the portal region, including the alphaI- and alphaII-helices and the beta C-D turn, resulted in much slower 2-(9-anthroyloxy)palmitate (2AP) transfer rates to acidic membranes than those of native AFABP.	Lysine	51-57	fatty acid binding protein 4, adipocyte	Mus musculus	258-263
11371211-8	2001	These studies suggest that lysines in the helical cap domain are important for governing ionic interactions between AFABP and membranes.	Lysine	27-34	fatty acid binding protein 4, adipocyte	Mus musculus	116-121
33739886-8	2021	The possible PCB interaction with Sox4 transcriptional protein was confirmed through molecular docking where three hydrogen bonds were formed at ARG and LYS residues at a stable binding energy of -4.72.	Lysine	153-156	SRY (sex determining region Y)-box 4	Mus musculus	34-38
11278418-3	2001	DHS mediates the first of two enzymatic reactions that activate eIF-5A by converting a conserved lysine to the unusual amino acid, deoxyhypusine.	Lysine	97-103	deoxyhypusine synthase	Solanum lycopersicum	0-3
21518757-0	2011	TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.	Lysine	23-26	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	75-83
21518757-0	2011	TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.	Lysine	23-26	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	85-114
21518757-0	2011	TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.	Lysine	23-26	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	116-120
21518757-3	2011	TRAF7 promotes Lys-29-linked polyubiquitination of NEMO and p65 that results in lysosomal degradation of both proteins and altered activation.	Lysine	15-18	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	51-55
11278418-3	2001	DHS mediates the first of two enzymatic reactions that activate eIF-5A by converting a conserved lysine to the unusual amino acid, deoxyhypusine.	Lysine	97-103	eukaryotic translation initiation factor 5A	Homo sapiens	64-70
33460788-3	2021	Brd4, a member of the bromodomain and extra-terminal domain (BET) protein family, serves as a chromatin "reader" by binding to histones in acetylated lysine residues, and hence promotes transcriptional activities.	Lysine	150-156	bromodomain containing 4	Mus musculus	0-4
11336656-8	2001	For alpha1 integrin/protein binding, the conserved Lys-Ile-Gly-Phe-Phe-Lys-Arg motif and, in particular, the two lysine residues, are important.	Lysine	51-54	adrenoceptor alpha 1D	Homo sapiens	4-10
11336656-8	2001	For alpha1 integrin/protein binding, the conserved Lys-Ile-Gly-Phe-Phe-Lys-Arg motif and, in particular, the two lysine residues, are important.	Lysine	113-119	adrenoceptor alpha 1D	Homo sapiens	4-10
11278664-7	2001	Mutant ST8Sia II and IV enzymes in which this His residue was changed to Lys showed no detectable enzyme activity, even though they were folded correctly and could bind to CDP-hexanolamine, suggesting the importance of the His residue for their catalytic activity.	Lysine	73-76	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	7-16
21129812-4	2011	During the median 26.5 months of follow-up, patients with the XPD 751Lys/Lys genotype had a median survival time of 17.0 months (95% CI, 14.5-19.6 months), not much longer than those carried Lys/Gln heterozygote (12.0 months; 95% CI, 3.4-20.6 months; log-rank test, P=0.542).	Lysine	69-72	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	62-65
21443952-5	2011	These comprehensive analyses have revealed (i) that RAD6 serves as the cognate E2 for the BRE1 complex in human cells, as previously established in yeast, (ii) that RAD6, through direct interaction with the BRE1 complex, ubiquitylates chromatinized H2B at lysine 120 and (iii) that PAF1 complex-mediated transcription is required for efficient H2B ubiquitylation.	Lysine	256-262	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	52-56
33636024-5	2021	Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4alpha (HNF4alpha) protein by binding to and deacetylating HNF4alpha on lysine 458.	Lysine	136-142	sirtuin 2	Mus musculus	17-22
21443952-5	2011	These comprehensive analyses have revealed (i) that RAD6 serves as the cognate E2 for the BRE1 complex in human cells, as previously established in yeast, (ii) that RAD6, through direct interaction with the BRE1 complex, ubiquitylates chromatinized H2B at lysine 120 and (iii) that PAF1 complex-mediated transcription is required for efficient H2B ubiquitylation.	Lysine	256-262	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	165-169
11238294-7	2001	RESULTS: One of the patient"s sisters had a missense mutation (Asp(407)--&gt;Lys) in exon 9 of the LDL receptor and a serum LDL-cholesterol concentration of 4.07 mmol/L.	Lysine	77-80	low density lipoprotein receptor	Homo sapiens	99-111
33754067-15	2021	At last, we identified that the lysine sites K127/131 and K185/187/189 of Fndc5 may contribute to the SIRT2-dependent deacetylation and deubiquitination of Fndc5.	Lysine	32-38	fibronectin type III domain containing 5	Mus musculus	74-79
11157057-2	2001	Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.	Lysine	16-22	major histocompatibility complex, class I, B	Homo sapiens	135-142
21764993-3	2011	RPN10 and members of the UBL-UBA-containing RAD23 and DSK2 families displayed strong affinities for Lys-48-linked ubiquitin chains (the major UPP signals), indicating that they are involved in ubiquitylated substrate recognition.	Lysine	100-103	regulatory particle non-ATPase 10	Arabidopsis thaliana	0-5
21554885-0	2011	Immunoassay for the discrimination of free prostate-specific antigen (fPSA) forms with internal cleavages at Lys(145) or Lys(146) from fPSA without internal cleavages at Lys(145) or Lys(146).	Lysine	109-112	kallikrein related peptidase 3	Homo sapiens	43-68
11042210-0	2001	Two conserved lysines at the 50/20-kDa junction of myosin are necessary for triggering actin activation.	Lysine	14-21	myosin heavy chain 14	Homo sapiens	51-57
33754067-15	2021	At last, we identified that the lysine sites K127/131 and K185/187/189 of Fndc5 may contribute to the SIRT2-dependent deacetylation and deubiquitination of Fndc5.	Lysine	32-38	sirtuin 2	Mus musculus	102-107
11042210-5	2001	We further show that the 16 amino acids of loop 2 preceding the lysine-rich region are not essential for actin activation, although they do modulate myosin"s affinity for actin in the presence of ATP.	Lysine	64-70	myosin heavy chain 14	Homo sapiens	149-155
33754067-15	2021	At last, we identified that the lysine sites K127/131 and K185/187/189 of Fndc5 may contribute to the SIRT2-dependent deacetylation and deubiquitination of Fndc5.	Lysine	32-38	fibronectin type III domain containing 5	Mus musculus	156-161
33174606-2	2021	Here, we show that UTX, a demethylase for lysine 27 on histone H3 (H3K27) and a component of Compass-like and SWI/SNF complexes, plays an essential role in the hematopoietic system by globally regulating aging-associated genes.	Lysine	42-48	lysine (K)-specific demethylase 6A	Mus musculus	19-22
11060315-1	2001	Hypusine is formed through a spermidine-dependent posttranslational modification of eukaryotic initiation factor 5A (eIF-5A) at a specific lysine residue.	Lysine	139-145	eukaryotic translation initiation factor 5A	Homo sapiens	84-115
11060315-1	2001	Hypusine is formed through a spermidine-dependent posttranslational modification of eukaryotic initiation factor 5A (eIF-5A) at a specific lysine residue.	Lysine	139-145	eukaryotic translation initiation factor 5A	Homo sapiens	117-123
21697825-7	2011	Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region.	Lysine	144-147	histamine receptor H1	Homo sapiens	37-42
21697825-7	2011	Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region.	Lysine	165-168	histamine receptor H1	Homo sapiens	37-42
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	141-147	transforming growth factor beta 1 induced transcript 1	Homo sapiens	67-72
21515881-4	2011	Molecular mechanistic dissection with mutation analysis found that ARA55 could enhance TR4 acetylation at the conserved acetylation sites of lysine 175 and lysine 176 in the DNA-binding domain via recruiting proteins with histone acetyl transferase activity, which might then reduce significantly the TR4 DNA binding activity that resulted in the suppression of TR4 transactivation.	Lysine	156-162	transforming growth factor beta 1 induced transcript 1	Homo sapiens	67-72
11013234-7	2001	The main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.	Lysine	191-197	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	42-47
33628191-8	2021	Interestingly, acetylation of STAT3 at lysine 685 (AcK685) was reduced in ocular hypertensive animals and subsequently increased significantly by SNC-121 treatment.	Lysine	39-45	signal transducer and activator of transcription 3	Rattus norvegicus	30-35
11013234-7	2001	The main physiological roles of Odc1p and Odc2p are probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.	Lysine	234-240	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	42-47
11460477-2	2001	We have characterized the lysine residues in fibrinogen to which PAI-2 is crosslinked by tissue transglutaminase and factor XIIIa.	Lysine	26-32	serpin family B member 2	Homo sapiens	65-70
11460477-4	2001	PAI-2 was crosslinked to several lysine residues, all in the A alpha chain, 148, 176, 183, 230, 413, and 457, but not to Lys 303.	Lysine	33-39	serpin family B member 2	Homo sapiens	0-5
21660059-1	2011	Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4.	Lysine	144-150	lysine methyltransferase 2A	Homo sapiens	33-36
33058867-8	2021	RESULTS: TGFbeta stimulation caused widespread changes in histone 3 lysine 27 acetylation (H3K27ac), and was associated with global TGFbeta-mediated transcription.	Lysine	68-74	transforming growth factor alpha	Mus musculus	9-16
21073857-5	2011	Both rapamycin and LY-294002 decreased EGF-induced Mg2+ influx.	Lysine	19-21	epidermal growth factor	Homo sapiens	39-42
11642611-8	2001	TCR transgenic T cells specific to cytochrome c peptide 88-104 acquired the capacity to respond to the low-affinity analogue at position 99 (lys--&gt;ala) if PAHA was present during their development.	Lysine	141-144	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-3
33245804-3	2021	Here, we show that substitutions of alanine, glutamic acid, or lysine for the conserved residue tryptophan at position 122 (W122 ) in tobacco vein banding mosaic virus (TVBMV) CP abolished virus cell-to-cell movement in Nicotiana benthamiana plants.	Lysine	63-69	ceruloplasmin	Homo sapiens	176-178
11150848-2	2001	Complete sequencing of FUT6 genes in these individuals revealed the presence of two point mutations, i.e., G739 to A (Glu--&gt;247 to Lys) and C945 to A (Tyr--&gt;315 to stop).	Lysine	134-137	fucosyltransferase 6	Homo sapiens	23-27
11161242-9	2001	Two nucleotide changes, G785A and C786A, in codon 262 of the FUT1 gene resulted in the replacement of serine by lysine.	Lysine	112-118	fucosyltransferase 1 (H blood group)	Homo sapiens	61-65
21586903-3	2011	In addition to having roles in DNA replication initiation, the human Origin Recognition Complex (ORC) binds along with ORC-associated proteins ORCA/ LRWD1 to prominent transcriptional repressive lysine methylation marks and localizes to HP1-containing heterochromatic structures.	Lysine	195-201	chromobox 5	Homo sapiens	237-240
21431622-4	2011	Glutaric aciduria type I is caused by inherited deficiency of glutaryl-CoA dehydrogenase which is involved in the catabolic pathways of L-lysine, L-hydroxylysine and L-tryptophan.	Lysine	136-144	glutaryl-CoA dehydrogenase	Homo sapiens	62-88
33323973-4	2021	Then, we identified its upstream regulator UBE2T which promotes GC progression via hyperactivating the Wnt/beta-catenin signaling pathway through the ubiquitination and degradation of RACK1 at the lysine K172, K225, and K257 residues independent of an E3 ligase.	Lysine	197-203	catenin beta 1	Homo sapiens	107-119
21781587-14	2011	Immunohistochemistry results demonstrated that the expressions of p-ERK and p-Akt in treated groups were lower than that in control group, of which LY + PD group was the lowest one.	Lysine	148-150	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	66-71
11085934-5	2000	In addition, AGT-Ser-Lys-Leu was targeted to peroxisomes in Saccharomyces cerevisiae, whereas AGT-Lys-Lys-Leu was not.	Lysine	21-24	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	13-16
11085934-5	2000	In addition, AGT-Ser-Lys-Leu was targeted to peroxisomes in Saccharomyces cerevisiae, whereas AGT-Lys-Lys-Leu was not.	Lysine	98-101	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	94-97
10921925-1	2000	Lysines in apolipoprotein (apo) E are key factors in the binding of apoE to the low density lipoprotein receptor, and high affinity binding requires that apoE be associated with lipid.	Lysine	0-7	low density lipoprotein receptor	Homo sapiens	80-112
33473116-4	2021	SUMOylation of PKM2 lysine 270 (K270) triggered conformation change from tetrameric to dimeric of PKM2, reduced PK activity, and led to nuclear translocation of PKM2.	Lysine	20-26	pyruvate kinase M1/2	Homo sapiens	15-19
11038281-5	2000	The best of these substrates, (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2, 4-dinitrophenyl), is hydrolyzed by ECE-1 with a k(cat)/K(m) value of 1.9 x 10(7) M(-1) s(-1), making it the most sensitive substrate yet described for ECE-1.	Lysine	93-96	endothelin converting enzyme 1	Homo sapiens	135-140
11038281-5	2000	The best of these substrates, (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2, 4-dinitrophenyl), is hydrolyzed by ECE-1 with a k(cat)/K(m) value of 1.9 x 10(7) M(-1) s(-1), making it the most sensitive substrate yet described for ECE-1.	Lysine	93-96	endothelin converting enzyme 1	Homo sapiens	251-256
21549103-6	2011	Determination of the ubiquitination site(s) in Tob by mass spectrometric analysis revealed that two lysine residues (Lys48 and Lys63) located in Tob/BTG homology domain are ubiquitinated.	Lysine	100-106	transducer of ERBB2, 1	Homo sapiens	47-50
21549103-6	2011	Determination of the ubiquitination site(s) in Tob by mass spectrometric analysis revealed that two lysine residues (Lys48 and Lys63) located in Tob/BTG homology domain are ubiquitinated.	Lysine	100-106	transducer of ERBB2, 1	Homo sapiens	145-148
21320486-6	2011	We determined that the ubiquitin ligase Nedd4 enhances polyubiquitination of APPL1, and the ubiquitin molecules attached to APPL1 are linked through lysine-63.	Lysine	149-155	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	40-45
33473116-4	2021	SUMOylation of PKM2 lysine 270 (K270) triggered conformation change from tetrameric to dimeric of PKM2, reduced PK activity, and led to nuclear translocation of PKM2.	Lysine	20-26	pyruvate kinase M1/2	Homo sapiens	98-102
21320486-6	2011	We determined that the ubiquitin ligase Nedd4 enhances polyubiquitination of APPL1, and the ubiquitin molecules attached to APPL1 are linked through lysine-63.	Lysine	149-155	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	124-129
11086929-5	2000	The release rate of model drugs (salicylic acid, theophylline, and bovine insulin) from the prepared hydrogels ranked as follows: NaOH&gt;lysine&gt;arginine, the sustained-release profile being observed with arginine.	Lysine	138-144	insulin	Bos taurus	74-81
33450879-0	2021	Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells.	Lysine	0-6	aminoadipate aminotransferase	Homo sapiens	31-36
11443278-12	2000	Replacing the lysine residue in the -3 position by leucine resulted in plasma membrane expression of the OST48-Leu polypeptide, indicating that this sequence motif may be able to influence OST48 localisation.	Lysine	14-20	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	105-110
11443278-12	2000	Replacing the lysine residue in the -3 position by leucine resulted in plasma membrane expression of the OST48-Leu polypeptide, indicating that this sequence motif may be able to influence OST48 localisation.	Lysine	14-20	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	189-194
21498567-3	2011	Among the identified HKMTs in mammals, G9a and GLP are the primary enzymes for mono- and dimethylation at Lys 9 of histone H3 (H3K9me1 and H3K9me2), and exist predominantly as a G9a-GLP heteromeric complex that appears to be a functional H3K9 methyltransferase in vivo.	Lysine	106-109	euchromatic histone lysine methyltransferase 1	Homo sapiens	47-50
21486482-3	2011	One of the proteins, MOF (males absent on the first), is a histone acetyltransferase that specifically acetylates histone H4 at lysine 16.	Lysine	128-134	males absent on the first	Drosophila melanogaster	21-24
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	55-61	aminoadipate aminotransferase	Homo sapiens	80-115
11057907-4	2000	We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.	Lysine	151-157	TNF receptor associated factor 6	Homo sapiens	13-18
11057907-4	2000	We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.	Lysine	151-157	ubiquitin conjugating enzyme E2 N	Homo sapiens	67-72
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	55-61	aminoadipate aminotransferase	Homo sapiens	117-122
11057907-4	2000	We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.	Lysine	151-157	ubiquitin conjugating enzyme E2 V1	Homo sapiens	73-78
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	55-61	aminoadipate aminotransferase	Homo sapiens	175-180
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	140-146	aminoadipate aminotransferase	Homo sapiens	80-115
21486482-9	2011	In its absence, the activity of the MOF subunit was compromised, and the complex failed to acetylate histone H4 at lysine 16.	Lysine	115-121	males absent on the first	Drosophila melanogaster	36-39
11014211-3	2000	We report the novel finding that all ECMs tested, but not a nonspecific attachment factor, poly-L-lysine (PL), promoted a highly synergistic proliferative response to EGF plus IGF-I.	Lysine	91-104	epidermal growth factor	Mus musculus	167-170
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	140-146	aminoadipate aminotransferase	Homo sapiens	117-122
33450879-7	2021	Moreover, we found that expression of the gene for the lysine catabolism enzyme alpha-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR-AKT signaling.	Lysine	140-146	aminoadipate aminotransferase	Homo sapiens	175-180
33408182-5	2021	Inactivation of KAT7 decreased histone H3 lysine 14 acetylation, repressed p15INK4b transcription, and alleviated hMPC senescence.	Lysine	42-48	lysine acetyltransferase 7	Homo sapiens	16-20
11106181-1	2000	A sequence variant of human MIP-1alpha, in which Asp26 has been replaced by Al alpha, has been chemically modified by the addition of 13C-labeled methyl groups at each of the lysine residues and the N-terminus.	Lysine	175-181	C-C motif chemokine ligand 3	Homo sapiens	28-38
21423168-8	2011	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	Lysine	114-120	HOXA distal transcript antisense RNA	Homo sapiens	0-6
33911375-1	2021	Introduction: Glutaric aciduria type I is an autosomal recessive disorder of lysine metabolism due to the defect of the enzyme glutaryl-CoA dehydrogenase.	Lysine	77-83	glutaryl-CoA dehydrogenase	Homo sapiens	127-153
21371431-2	2011	Thus, ATP binding lysine 476 of NAIP, which is located at the Nucleotide Binding Oligomerization Domain (NOD) was mutated to threonine and the effect of this mutation on autoproteolysis of procaspase-9 and the cleavage of procaspase-3 by apoptosome was investigated.	Lysine	18-24	NLR family apoptosis inhibitory protein	Homo sapiens	32-36
11006099-2	2000	We investigated some features of these two models for the GluR1 subunit by inserting epitope tags between residues Lys(502)-Pro(503), Ala(632)-Glu(633), Lys(712)-Pro(713), or after the C-terminal residue Leu(889).	Lysine	115-118	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	58-63
11006099-4	2000	The epitope tag inserted between residues Lys(712)-Pro(713) is extracellular and after Leu(889) intracellular.	Lysine	42-45	long intergenic non-protein coding RNA 1194	Homo sapiens	12-15
10965040-3	2000	The results suggest that the P1 reactive center site (position 70 of STI2) for protease subtilisin BPN" or trypsin may be the prime Lys residue that can be recognized by MTG, when succinylated beta-casein was used as a partner Gln-substrate.	Lysine	132-135	tetratricopeptide repeat domain 21A	Homo sapiens	69-73
33191170-11	2021	Notably, the 2DG-PLGA-NPs augmented chemokine (CXCL9/CXCL10) production in liver tumors via interferon-gamma-Janus kinase-signal transducers and activator of transcription pathway and AMP-activated protein kinase-mediated suppression of histone H3 lysine 27 trimethylation.	Lysine	248-254	chemokine (C-X-C motif) ligand 9	Mus musculus	47-52
10945842-2	2000	The aryloxypropanolamines CGP 12177 and LY 362884, originally developed as beta(3)-AR agonists, were found to stimulate the beta(1)-AR.	Lysine	40-42	adrenoceptor beta 3	Homo sapiens	75-85
21256110-3	2011	The current report describes Lys 422 mutations (K422C, K422E) that have no effect on transport activity when introduced into wild-type PCFT but result in a marked loss of activity when introduced into a Cys-less PCFT which is otherwise near-fully functional.	Lysine	29-32	solute carrier family 46 member 1	Homo sapiens	135-139
21256110-3	2011	The current report describes Lys 422 mutations (K422C, K422E) that have no effect on transport activity when introduced into wild-type PCFT but result in a marked loss of activity when introduced into a Cys-less PCFT which is otherwise near-fully functional.	Lysine	29-32	solute carrier family 46 member 1	Homo sapiens	212-216
10934255-3	2000	Here, we have provided evidence that intracellular signaling by the alpha(1)beta(1) integrin-induced activation of cyclin-dependent kinase 5 (cdk5) is involved in neurite outgrowth and human neurofilament protein H (hNF-H) Lys-Ser-Pro (KSP) tail domain phosphorylation in differentiated human SH-SY5Y cells.	Lysine	223-226	cyclin dependent kinase 5	Homo sapiens	115-140
21344134-7	2011	According to the three-dimensional structure of the human SRY HMG-box, the substitution of the conserved glutamic acid residue by the basic lysine at position 89 introduces an extra positive charge adjacent to and between the positively charged residues R86 and K92, important for stabilizing the HMG-box helix 2 with DNA.	Lysine	140-146	sex determining region Y	Homo sapiens	58-61
10934255-3	2000	Here, we have provided evidence that intracellular signaling by the alpha(1)beta(1) integrin-induced activation of cyclin-dependent kinase 5 (cdk5) is involved in neurite outgrowth and human neurofilament protein H (hNF-H) Lys-Ser-Pro (KSP) tail domain phosphorylation in differentiated human SH-SY5Y cells.	Lysine	223-226	cyclin dependent kinase 5	Homo sapiens	142-146
33197229-3	2021	Here, we focus on the function and regulation of lysine 20 of histone H4 (H4K20) methylation in multiple biological processes including DNA repair, cell cycle regulation and DNA replication.	Lysine	49-55	H4 clustered histone 2	Homo sapiens	62-72
10949293-3	2000	Here we show that human SUV39H1 and murine Suv39h1--mammalian homologues of Drosophila Su(var)3-9 and of Schizosaccharomyces pombe clr4--encode histone H3-specific methyltransferases that selectively methylate lysine 9 of the amino terminus of histone H3 in vitro.	Lysine	210-216	suppressor of variegation 3-9 1	Mus musculus	43-50
10825373-4	2000	The NK(2) receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK(1) and NK(3) receptor-selective agonists, [Sar(9), Met(O(2))(11)]SP and [N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors.	Lysine	39-42	tachykinin precursor 3	Homo sapiens	238-241
21282469-3	2011	We first show that PTIP is recruited to a Pax5 binding site to promote histone H3 lysine 4 (H3K4) methylation.	Lysine	82-88	PAX interacting protein 1	Homo sapiens	19-23
21239494-0	2011	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	Lysine	0-3	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	44-49
21239494-4	2011	Further, we also demonstrated that USP17 specifically deubiquitinates Lys-63-linked ubiquitin chains from SDS3 and regulates its biological functions.	Lysine	70-73	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	35-40
33362225-6	2020	Mass spectrometry analysis of purified Atg32 protein revealed that at least lysine residue in position 282 is ubiquitinated.	Lysine	76-82	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	39-44
10851091-4	2000	Within the INK4 family, this regulatory mode appears restricted to p19INK4d whose ubiquitination was dependent on the integrity of lysine 62, and binding to CDK4.	Lysine	131-137	cyclin dependent kinase inhibitor 2D	Homo sapiens	67-75
33362225-7	2020	Interestingly, the replacement of lysine 282 with alanine impaired Atg32 degradation only partially in the course of cell growth, suggesting that additional lysine residues on Atg32 might also be ubiquitinated.	Lysine	34-40	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	67-72
10736562-1	2000	MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence.	Lysine	211-218	MARCKS like 1	Homo sapiens	86-108
33362225-7	2020	Interestingly, the replacement of lysine 282 with alanine impaired Atg32 degradation only partially in the course of cell growth, suggesting that additional lysine residues on Atg32 might also be ubiquitinated.	Lysine	34-40	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	176-181
10736562-1	2000	MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence.	Lysine	211-218	MARCKS like 1	Homo sapiens	110-113
33339442-1	2020	The histone methyltransferase SETD8, which methylates the lysine 20 of histone H4 (H4K20), is reportedly involved in human carcinogenesis along with nonhistone proteins such as p53.	Lysine	58-64	H4 clustered histone 6	Homo sapiens	71-81
10850813-2	2000	This structure accurately predicts the copolymerization of hybridized mixtures of HbS with HbA or HbC (beta6 Glu--&gt;Lys), which could not be reconciled with prior models in which only half the beta6 sites were required for assembly.	Lysine	118-121	keratin 88, pseudogene	Homo sapiens	98-101
21445285-1	2011	BACKGROUND: Different histone post-translational modifications (PTMs) are crucial in the regulation of chromatin, including methylations of H3 at Lysine 4 by the MLL complex.	Lysine	146-152	lysine methyltransferase 2A	Homo sapiens	162-165
21445315-4	2011	Thus, in brm mutant plants FLC expression is elevated, and FLC chromatin exhibits increased levels of histone H3 lysine 4 tri-methylation and decreased levels of H3 lysine 27 tri-methylation, indicating that BRM imposes a repressive chromatin configuration at the FLC locus.	Lysine	113-119	transcription regulatory protein SNF2	Arabidopsis thaliana	9-12
33298158-8	2020	Chromatin immunoprecipitation and Western blot analyses found that GSK-J4 treatment elevated the levels of the Kdm6a and Kdm6b epigenetic target, the repressive mark of tri-methylated lysine 27 on histone 3, on osteogenic genes leading to repression of Runx2 and Alkaline Phosphatase expression.	Lysine	184-190	lysine (K)-specific demethylase 6A	Mus musculus	111-116
22238144-0	2011	The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.	Lysine	68-74	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	39-44
21972110-5	2011	Eleven of 12 Sotos mutations in PHD4, PHD5, and PHD6 disrupted binding to these methylated lysines, and 8 of 9 mutations in PHD4 and PHD6 severely compromised binding to transcription cofactor Nizp1.	Lysine	91-98	prolyl 4-hydroxylase, transmembrane	Homo sapiens	32-36
10781022-6	2000	A lysine on TM4 and an aspartate on TM5 interacted with the aldehyde moiety of octanal.	Lysine	2-8	tropomyosin 4	Rattus norvegicus	12-15
10755371-1	2000	Allysine is the most important precursor of physiologically essential cross-links formation in collagen and elastin and is formed by enzymatic oxidative deamination of lysine residues.	Lysine	2-8	elastin	Bos taurus	108-115
33299050-3	2020	Here, we identify new unnatural lysine analogues as substrates for human methyltransferases SETD7, SETD8, G9a and GLP.	Lysine	32-38	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	92-97
21144910-0	2011	A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein.	Lysine	9-15	LDL receptor related protein associated protein 1	Homo sapiens	72-99
21144910-0	2011	A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein.	Lysine	27-33	LDL receptor related protein associated protein 1	Homo sapiens	72-99
32866343-1	2020	Inspired by the amino acid composition of natural protein surfaces, we developed a zwitterionic cloak containing multi-layers of short alternating glutamic acid and lysine (EK) peptides as a facile, highly effective and low-immunogenicity approach for the protection and delivery of biotherapeutics.	Lysine	165-171	choline kinase alpha	Homo sapiens	173-175
21293379-1	2011	p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the recruitment of 53BP1 to double-strand breaks (DSBs).	Lysine	128-134	tumor protein p53 binding protein 1	Homo sapiens	23-28
21293379-1	2011	p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the recruitment of 53BP1 to double-strand breaks (DSBs).	Lysine	128-134	tumor protein p53 binding protein 1	Homo sapiens	180-185
21209336-8	2011	First, Urm1 is appended to lysine residues of three components that function in its own pathway (i.e., MOCS3, ATPBD3, and CTU2).	Lysine	27-33	molybdenum cofactor synthesis 3	Homo sapiens	103-108
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Lysine	186-189	oxidized low density lipoprotein receptor 1	Bos taurus	24-29
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Lysine	186-189	oxidized low density lipoprotein receptor 1	Bos taurus	120-125
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Lysine	186-189	oxidized low density lipoprotein receptor 1	Bos taurus	120-125
10681560-13	2000	A deletion in the carboxyl region or a mutation on the last lysine residue of the carboxyl end had a detrimental effect on the level of Flag-SPRR1 fusion protein expressed in transfected cells.	Lysine	60-66	small proline rich protein 1B	Homo sapiens	141-146
21209336-8	2011	First, Urm1 is appended to lysine residues of three components that function in its own pathway (i.e., MOCS3, ATPBD3, and CTU2).	Lysine	27-33	cytosolic thiouridylase subunit 1	Homo sapiens	110-116
32866343-2	2020	Each EK layer grafted to proteins provides multiple times of new lysine reaction sites for the growth of subsequent EK layers.	Lysine	65-71	choline kinase alpha	Homo sapiens	5-7
32866343-2	2020	Each EK layer grafted to proteins provides multiple times of new lysine reaction sites for the growth of subsequent EK layers.	Lysine	65-71	choline kinase alpha	Homo sapiens	116-118
32866343-3	2020	This unique design allows EK peptides to achieve high coating density on proteins, overcoming the limitation of traditional conjugation strategies that rely on the number of innate lysine groups.	Lysine	181-187	choline kinase alpha	Homo sapiens	26-28
10693811-3	2000	Lysines 9 and 14 of histone H3 and lysines 5, 8 and 16 of H4 are acetylated in active chromatin and hypoacetylated in silenced chromatin, and overexpression of Sir2 promotes global deacetylation of histones, indicating that Sir2 may be a histone deacetylase.	Lysine	0-7	sirtuin 1	Mus musculus	160-164
33285161-10	2021	The administration of LTD4 to Ptges-/- mice, which display enhanced LTC4 synthesis similar to aspirin exacerbated respiratory disease (AERD), completely blocked the physiologic response to subsequent lysine-aspirin inhalation challenges, as well as increases in IL-33, type 2 cytokines, and biochemical markers of mast cell and platelet activation.	Lysine	200-206	prostaglandin E synthase	Mus musculus	30-35
10693811-3	2000	Lysines 9 and 14 of histone H3 and lysines 5, 8 and 16 of H4 are acetylated in active chromatin and hypoacetylated in silenced chromatin, and overexpression of Sir2 promotes global deacetylation of histones, indicating that Sir2 may be a histone deacetylase.	Lysine	35-42	sirtuin 1	Mus musculus	160-164
10693811-5	2000	Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases, which deacetylate lysines 9 and 14 of H3 and specifically lysine 16 of H4.	Lysine	142-149	sirtuin 1	Mus musculus	34-38
10693811-5	2000	Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases, which deacetylate lysines 9 and 14 of H3 and specifically lysine 16 of H4.	Lysine	142-148	sirtuin 1	Mus musculus	34-38
21068446-4	2011	beta-TrCP ubiquitinates LPCAT1 at an acceptor site (Lys(221)), as substitution of Lys(221) with Arg abrogated LPCAT1 polyubiquitination.	Lysine	52-55	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	0-9
21103576-7	2011	The MnO(2)-C/Chit/GC electrode exhibited excellent stability (without any decrease of the response signal after 1 month) and admirable resistance against interference like glutathione and other oxidizable amino acids (tryptophan, tyrosine, L-lysine and methionine).	Lysine	240-248	chitinase 1	Homo sapiens	13-17
33273685-5	2020	Deletion of the TDH2 gene, which encodes glyceraldehyde 3-phospho dehydrogenase and is essential for glycolysis/gluconeogenesis, partially suppressed DNA damage sensitivity due to chromatin structure, which was persistently acetylated histone H3 on lysine 56 in cells with deletions of both HST3 and HST4, encoding NAD+-dependent deacetylases.	Lysine	249-255	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2	Saccharomyces cerevisiae S288C	16-20
21078669-7	2011	Guided by structural bioinformatics including protein-protein docking, we revealed that the amino acids Arg(63), Lys(70), Lys(101), Glu(138), Asp(139), and Asn(160) engage in intermolecular salt bridges within the anxA5 trimer, which is the basic building block of the two-dimensional network.	Lysine	113-116	annexin A5	Homo sapiens	214-219
21078669-7	2011	Guided by structural bioinformatics including protein-protein docking, we revealed that the amino acids Arg(63), Lys(70), Lys(101), Glu(138), Asp(139), and Asn(160) engage in intermolecular salt bridges within the anxA5 trimer, which is the basic building block of the two-dimensional network.	Lysine	122-125	annexin A5	Homo sapiens	214-219
21119616-3	2011	In pRb, lysine (K) 810 represents the essential and conserved basic residue (SPXK) required for cyclin/Cdk recognition and phosphorylation.	Lysine	8-14	proliferating cell nuclear antigen	Homo sapiens	96-102
10639328-2	2000	The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation.	Lysine	148-151	neurofilament heavy chain	Homo sapiens	41-45
10639328-2	2000	The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation.	Lysine	148-151	neurofilament heavy chain	Homo sapiens	104-108
10735543-1	2000	BACKGROUND: Previous in vitro experiments have indicated that if the ninth codon of the hepatitis C virus (HCV) core gene is mutated from arginine to lysine, a short 16-kDa (P16) instead of a 21-kDa (P21) core protein will be produced.	Lysine	150-156	H3 histone pseudogene 16	Homo sapiens	200-203
33273685-6	2020	tdh2 deletion also restored the short replicative lifespan of cells with deletion of sir2, another NAD+-dependent deacetylase, by suppressing intrachromosomal recombination in rDNA repeats increased by the unacetylated histone H4 on lysine 16.	Lysine	233-239	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2	Saccharomyces cerevisiae S288C	0-4
32555448-3	2020	PHD finger protein 20 (PHF20) is a multidomain protein and subunit of a lysine acetyltransferase complex that acetylates histone H4 and p53, but its function is unclear.	Lysine	72-78	PHD finger protein 20	Mus musculus	0-21
10625480-8	2000	We speculate that a reaction between a carbonyl on one actin polymer subunit and a lysine on a neighboring subunit is responsible for ANF formation.	Lysine	83-89	natriuretic peptide A	Bos taurus	134-137
10619850-0	2000	A non-canonical lon proteinase lacking the ATPase domain employs the ser-Lys catalytic dyad to exercise broad control over the life cycle of a double-stranded RNA virus.	Lysine	73-76	lon peptidase 1, mitochondrial	Homo sapiens	16-19
21167713-6	2011	Furthermore, we find that the binding of histone-interaction domains from BPTF, CHD1, and RAG2 to H3 lysine 4 trimethylation is also influenced by combinatorial PTMs.	Lysine	101-107	recombination activating 2	Homo sapiens	90-94
21915788-4	2011	In this process, small RNAs of ~28-29 nt, which are processed by the Dicer-like protein Dcl1p and are associated with the Argonaute family protein Twi1p, induce heterochromatin formation at complementary genomic sequences by recruiting the histone H3 lysine 9/27 methyltransferase Ezl1p and chromodomain proteins.	Lysine	251-257	CD302 molecule	Homo sapiens	88-93
20837137-0	2011	TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	5-11	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
11193762-6	2000	In the known uteroglobin structures, this lysine forms an exposed salt bridge with an aspartate side chain, which is conserved in almost all sequences.	Lysine	42-48	secretoglobin family 1A member 1	Homo sapiens	13-24
32555448-3	2020	PHD finger protein 20 (PHF20) is a multidomain protein and subunit of a lysine acetyltransferase complex that acetylates histone H4 and p53, but its function is unclear.	Lysine	72-78	PHD finger protein 20	Mus musculus	23-28
32555448-3	2020	PHD finger protein 20 (PHF20) is a multidomain protein and subunit of a lysine acetyltransferase complex that acetylates histone H4 and p53, but its function is unclear.	Lysine	72-78	transformation related protein 53, pseudogene	Mus musculus	136-139
33130515-4	2020	The paralogous lysine acetyltransferases KAT6A and KAT6B which belong to the MYST family of acetyltransferases, were first discovered approximately 25 years ago.	Lysine	15-21	lysine acetyltransferase 6B	Homo sapiens	51-56
20837137-0	2011	TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	5-11	TNF receptor associated factor 6	Homo sapiens	49-54
33130515-4	2020	The paralogous lysine acetyltransferases KAT6A and KAT6B which belong to the MYST family of acetyltransferases, were first discovered approximately 25 years ago.	Lysine	15-21	lysine acetyltransferase 6A	Homo sapiens	77-81
20837137-3	2011	However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 polyubiquitination acceptor site in TGF-beta signaling pathway.	Lysine	34-40	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	52-56
20837137-3	2011	However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 polyubiquitination acceptor site in TGF-beta signaling pathway.	Lysine	34-40	TNF receptor associated factor 6	Homo sapiens	60-65
10717388-10	2000	Fpg expression suppresses the spontaneous mutator phenotype of ogg1- yeast for the production of canavanin resistant mutants (CanR) and Lys+ revertants.	Lysine	136-139	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	63-67
20837137-3	2011	However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 polyubiquitination acceptor site in TGF-beta signaling pathway.	Lysine	34-40	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	75-79
33318631-3	2020	Moreover, it has been recently found to demethylate monomethylated and dimethylated lysine 20 in histone H4 and to contribute to the balance of several other methylated lysine residues in histone H3 (i.e., H3K27, H3K36, and H3K79).	Lysine	84-90	H4 clustered histone 6	Homo sapiens	97-107
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	34-38
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	TNF receptor associated factor 6	Homo sapiens	72-77
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	87-91
20837137-4	2011	Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation.	Lysine	20-26	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	87-91
16232702-2	2000	This proteolytic cleavage was inhibited significantly by the addition of high concentrations of l-arginine and l-lysine, with a resultant marked improvement in the yield of intact hLC1.	Lysine	111-119	NADH:ubiquinone oxidoreductase subunit C2	Homo sapiens	180-184
32814111-19	2020	Knockdown of lysine demethylases, or succinate supplementation, restored expression of LGR5 to SLC25A22-knockout CRC cells.	Lysine	13-19	solute carrier family 25 member 22	Homo sapiens	95-103
10594033-4	2000	We have partially purified a complex containing MSL1, -2, and -3, MOF, MLE, and roX2 RNA and demonstrated that it exclusively acetylates H4 at lysine 16 on nucleosomal substrates.	Lysine	143-149	males absent on the first	Drosophila melanogaster	66-69
20533040-4	2011	According to the results of in vivo enzyme assay and three-dimension structural model of Dunaliella salina (6-4) photolyase we hypothesized that Lys(281) might be involved in the photoreactivation over the pH range from 10.0 to 11.0.	Lysine	145-148	6-4 photolyase	Xenopus laevis	108-123
10608835-1	1999	We have performed a site-directed mutagenesis study showing that residues comprising the type I signal peptidase signature in the two catalytic subunits of the yeast inner membrane protease, Imp1p and Imp2p, are functionally important, consistent with the idea that these subunits contain a serine/lysine catalytic dyad.	Lysine	298-304	endopeptidase catalytic subunit IMP1	Saccharomyces cerevisiae S288C	191-196
32154934-5	2020	A crucial component of small ubiquitin-related modifiers (SUMOs) E3 ligase, RANBP2, is activated by SIRT1 and it is indispensable for FTO SUMOylation at Lysine (K)-216 site that promotes FTO degradation.	Lysine	153-159	RAN binding protein 2	Homo sapiens	76-82
10608835-1	1999	We have performed a site-directed mutagenesis study showing that residues comprising the type I signal peptidase signature in the two catalytic subunits of the yeast inner membrane protease, Imp1p and Imp2p, are functionally important, consistent with the idea that these subunits contain a serine/lysine catalytic dyad.	Lysine	298-304	endopeptidase catalytic subunit	Saccharomyces cerevisiae S288C	201-206
10637513-8	1999	Mutation of this serine to aspartate or glutamate, but not alanine, in combination with the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of serine-473 of protein kinase B.	Lysine	105-111	protein tyrosine kinase 2 beta	Homo sapiens	196-212
21205864-3	2011	In Drosophila, two enzymes, dLsd1 (Drosophila ortholog of lysine-specific demethylase 1) and Lid (little imaginal discs), demethylate histone H3 at Lys 4 (H3K4), a residue whose methylation is associated with actively transcribed genes.	Lysine	148-151	little imaginal discs	Drosophila melanogaster	93-96
22472282-4	2011	We elucidated the effect of lysine sufficiency on the dynamics of hormones, relevant to muscle protein synthesis and degradation, insulin-like growth factor-I (IGF-I) and corticosterone, and on the expression of proteolytic-related genes in skeletal muscle during compensatory growth.	Lysine	28-34	insulin-like growth factor 1	Rattus norvegicus	130-158
32154934-5	2020	A crucial component of small ubiquitin-related modifiers (SUMOs) E3 ligase, RANBP2, is activated by SIRT1 and it is indispensable for FTO SUMOylation at Lysine (K)-216 site that promotes FTO degradation.	Lysine	153-159	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	134-137
22472282-4	2011	We elucidated the effect of lysine sufficiency on the dynamics of hormones, relevant to muscle protein synthesis and degradation, insulin-like growth factor-I (IGF-I) and corticosterone, and on the expression of proteolytic-related genes in skeletal muscle during compensatory growth.	Lysine	28-34	insulin-like growth factor 1	Rattus norvegicus	160-165
22472282-8	2011	With the lysine sufficiency, serum IGF-I concentration increased (p&lt;0.05) whereas serum corticosterone decreased (p&lt;0.05).	Lysine	9-15	insulin-like growth factor 1	Rattus norvegicus	35-40
10606725-4	1999	The Cry1Aa toxin bound to the fragment containing 40-Asp to 313-Lys, suggesting that the Cry1Aa toxin-binding site is located in the region between 40-Asp and 313-Lys, while Cry1Ac toxin bound exclusively to mature APN.	Lysine	64-67	aminopeptidase N	Bombyx mori	215-218
10606725-4	1999	The Cry1Aa toxin bound to the fragment containing 40-Asp to 313-Lys, suggesting that the Cry1Aa toxin-binding site is located in the region between 40-Asp and 313-Lys, while Cry1Ac toxin bound exclusively to mature APN.	Lysine	163-166	aminopeptidase N	Bombyx mori	215-218
32154934-5	2020	A crucial component of small ubiquitin-related modifiers (SUMOs) E3 ligase, RANBP2, is activated by SIRT1 and it is indispensable for FTO SUMOylation at Lysine (K)-216 site that promotes FTO degradation.	Lysine	153-159	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	187-190
33247773-10	2020	Hence, we propose potential candidate genes that might be compensating the function of PLGRKT based on the presence of a C-terminal lysine residue, transmembrane domains, and gene expression patterns.	Lysine	132-138	plgrkt	None	87-93
10585950-0	1999	Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.	Lysine	31-37	H3 histone pseudogene 16	Homo sapiens	94-97
10625471-3	1999	One of the active site residues is lysine-32, which is postulated to play two roles: it assists in substrate binding through an interaction with a carboxylate oxygen at C-1 of phenylpyruvate, and it may be partially responsible for lowering the pK(a) of the catalytic base, Pro-1.	Lysine	35-41	lamin A/C	Homo sapiens	274-279
10625471-12	1999	The combination of these results indicates that the primary function of Lys-32 in the PPT activity of MIF is to lower the pK(a) of Pro-1.	Lysine	72-75	lamin A/C	Homo sapiens	131-136
21131967-0	2011	Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.	Lysine	0-6	euchromatic histone lysine methyltransferase 1	Homo sapiens	108-111
33149299-10	2020	The amplification of PI3K signals depends on IFITM3 using two lysine residues (Lys83 and Lys104) in its conserved intracellular loop as a scaffold for the accumulation of PIP3.	Lysine	62-68	interferon induced transmembrane protein 3	Mus musculus	45-51
22140559-6	2011	Conversely, epidermal growth factor receptor (EGFR)-mediated phosphorylation of the MUC1-C cytoplasmic domain on Tyr-46 conferred binding to PKM2 Lys-433 and inhibited PKM2 activity.	Lysine	146-149	pyruvate kinase M1/2	Homo sapiens	141-145
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Lysine	144-147	proprotein convertase subtilisin/kexin type 1	Homo sapiens	259-262
33253187-0	2020	Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology.	Lysine	48-54	cAMP-dependent protein kinase regulatory subunit BCY1	Saccharomyces cerevisiae S288C	96-100
10504448-5	1999	We again found the glutamine-lysine substitution (E413K) in the helix termination motif of hHb6 in two families, and in another, the corresponding E413K substitution in the hHb1 gene.	Lysine	29-35	keratin 86	Homo sapiens	91-95
10504448-5	1999	We again found the glutamine-lysine substitution (E413K) in the helix termination motif of hHb6 in two families, and in another, the corresponding E413K substitution in the hHb1 gene.	Lysine	29-35	keratin 86	Homo sapiens	173-177
21625555-1	2011	SET9, a protein lysine methyltransferase, has been thought to be capable of transferring only one methyl group to target lysine residues.	Lysine	16-22	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
21194439-12	2010	However, GSK-3beta inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310.	Lysine	98-104	glycogen synthase kinase 3 beta	Mus musculus	9-18
21194439-12	2010	However, GSK-3beta inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310.	Lysine	98-104	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	70-73
33253187-10	2020	We found that NuA4-dependent localization of Bcy1 is dependent on a lysine residue at position 313 of Bcy1.	Lysine	68-74	cAMP-dependent protein kinase regulatory subunit BCY1	Saccharomyces cerevisiae S288C	45-49
21194439-12	2010	However, GSK-3beta inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310.	Lysine	98-104	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	91-94
10491387-7	1999	The ubiquitination machinery and lysine residues within the NH(2)-terminal 31 amino acids of TAT2 mediate ubiquitination and degradation of the permease.	Lysine	33-39	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	93-97
33253187-10	2020	We found that NuA4-dependent localization of Bcy1 is dependent on a lysine residue at position 313 of Bcy1.	Lysine	68-74	cAMP-dependent protein kinase regulatory subunit BCY1	Saccharomyces cerevisiae S288C	102-106
33188174-5	2020	From adopting this multiplexed approach, we find that preformed 53BP1 dimers relocate from the nucleoplasm to DSB sites, where consecutive recognition of ubiquitinated lysine 15 of histone 2A (H2AK15ub) and di-methylated lysine 20 of histone 4 (H4K20me2), leads to the assembly of 53BP1 oligomers and a mature 53BP1 foci structure.	Lysine	168-174	tumor protein p53 binding protein 1	Homo sapiens	64-69
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Lysine	131-134	thrombomodulin	Homo sapiens	66-68
10455016-0	1999	Lysine mutagenesis identifies cationic charges of human CYP17 that interact with cytochrome b5 to promote male sex-hormone biosynthesis.	Lysine	0-6	cytochrome b5 type A	Homo sapiens	81-94
20940306-5	2010	Continued Myc expression prevented deacetylation of several lysine residues in histones H3 and H4 that are normally deacetylated during erythroid maturation.	Lysine	60-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	10-13
33188174-5	2020	From adopting this multiplexed approach, we find that preformed 53BP1 dimers relocate from the nucleoplasm to DSB sites, where consecutive recognition of ubiquitinated lysine 15 of histone 2A (H2AK15ub) and di-methylated lysine 20 of histone 4 (H4K20me2), leads to the assembly of 53BP1 oligomers and a mature 53BP1 foci structure.	Lysine	221-227	tumor protein p53 binding protein 1	Homo sapiens	64-69
21129218-4	2010	Cyclic voltammetry of the heme-binding domain of human cytochrome b5 (HLMWb5) and its site-directed mutants was conducted using a gold electrode pre-treated with beta-mercarptopropionic acid by inclusion of positively-charged poly-L-lysine.	Lysine	226-239	cytochrome b5 type A	Homo sapiens	55-68
10411539-6	1999	Adherence of ESC to various ECM substrates, except for poly-L-lysine, a non-integrin-dependent adhesion matrix, induced the expression of MCP-1 at both mRNA and protein levels.	Lysine	55-68	C-C motif chemokine ligand 2	Homo sapiens	138-143
32997115-7	2020	Overexpression of ZFAT increases the centromeric levels of both the histone acetyltransferase KAT2B and the acetylation at the lysine 8 in histone H4 (H4K8ac).	Lysine	127-133	zinc finger and AT hook domain containing	Mus musculus	18-22
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Lysine	27-33	pleckstrin	Homo sapiens	53-56
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Lysine	27-33	pleckstrin	Homo sapiens	57-61
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Lysine	27-33	pleckstrin	Homo sapiens	53-62
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	57-60
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	61-65
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	105-120
32843329-5	2020	Rat liver tritosomes and cathepsin B yielded IGN-P1 aniline, sulfonated IGN-P1 (s-IGN-P1) aniline and a lysine conjugate of IGN-P1 (IGN-P1-Lys) aniline as catabolites.	Lysine	104-110	cathepsin B	Rattus norvegicus	25-36
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	calcineurin like EF-hand protein 1	Homo sapiens	121-124
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	109-113
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	146-161
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	105-108
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Lysine	76-82	pleckstrin	Homo sapiens	109-113
10391914-9	1999	We conclude that the p47(phox) SH3A domain-binding site is blocked by an interaction between the p47(phox) SH3AB domains and the C-terminal arginine/lysine-rich region.	Lysine	149-155	pleckstrin	Homo sapiens	21-30
10391914-9	1999	We conclude that the p47(phox) SH3A domain-binding site is blocked by an interaction between the p47(phox) SH3AB domains and the C-terminal arginine/lysine-rich region.	Lysine	149-155	pleckstrin	Homo sapiens	97-106
20890731-3	2010	Likewise, histone acetyltransferase and SWI/SNF chromatin remodeling complexes each appear to be required for recombination, and the PHD-finger of RAG-2 preferentially associates with recombination signal sequence (RSS) chromatin that contains H3 trimethylated on lysine 4.	Lysine	264-270	recombination activating 2	Homo sapiens	147-152
20953165-2	2010	High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor.	Lysine	92-98	TATA-box binding protein associated factor 3	Homo sapiens	70-74
20953165-2	2010	High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor.	Lysine	92-98	relaxin 3	Homo sapiens	112-114
20953165-2	2010	High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in promoter recruitment of this basal transcription factor.	Lysine	92-98	relaxin 3	Homo sapiens	116-123
32578221-5	2020	Compared to dialysis, SPK transplantation incurs the greatest benefits in LYS and QALY for patients with type 1 diabetes requiring renal replacement therapy.	Lysine	74-77	symplekin scaffold protein	Homo sapiens	22-25
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	56-62	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	117-122
21078122-6	2010	A difference in the exposure to the solvent of a single lysine residue, lysine 339 of Ure2p, was detected upon Ure2p-Ssa1p complex formation.	Lysine	72-78	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	117-122
21078122-7	2010	These observations strongly suggest that lysine 339 and its flanking amino acid stretches are involved in the interaction between Ure2p and Ssa1p.	Lysine	41-47	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	140-145
20699270-3	2010	The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism.	Lysine	52-58	keratin 24	Homo sapiens	69-72
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Lysine	108-114	arginyl aminopeptidase	Rattus norvegicus	0-16
10456457-0	1999	Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor.	Lysine	15-18	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	52-75
10456457-0	1999	Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor.	Lysine	31-34	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	52-75
10456457-2	1999	Three lysine residues located in a positively charged cluster in the serine protease domain of protein C (PC) were mutated to probe their involvement in the heparin stimulation of inhibition by PCI.	Lysine	6-12	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	95-104
20798234-8	2010	These data suggest a model whereby DOT1L-dependent lysine 79 of histone H3 methylation serves as a critical regulator of a differentiation switch during early hematopoiesis, regulating steady-state levels of GATA2 and PU.1 transcription, thus controlling numbers of circulating erythroid and myeloid cells.	Lysine	51-57	Spi-1 proto-oncogene	Homo sapiens	218-222
10350461-0	1999	Trinitrophenylated reactive lysine residue in myosin detects lever arm movement during the consecutive steps of ATP hydrolysis.	Lysine	28-34	myosin heavy chain 14	Homo sapiens	46-52
10350461-1	1999	Trinitrophenylation of the reactive lysine (Lys84) in skeletal myosin subfragment 1 (S1) introduces a chiral probe (TNP) into an interface of the catalytic and lever arm domains of S1 [Muhlrad (1977) Biochim.	Lysine	36-42	myosin heavy chain 14	Homo sapiens	63-69
33047718-15	2020	Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) detected the m.8344A>G mutation of the MT-TK gene encoding mitochondrial transfer RNA for lysine in the patient"s blood.	Lysine	167-173	mitochondrially encoded tRNA lysine	Homo sapiens	116-121
10363586-1	1999	The Fab fragment of monoclonal antibody B4G7 against human epidermal growth factor (EGF) receptor was conjugated with cationic poly-L-lysine and the resulting conjugate was further complexed with reporter genes or therapeutic genes.	Lysine	127-140	FA complementation group B	Homo sapiens	4-7
20833725-5	2010	The aspartate finger of VPS9a recognizes GDP beta-phosphate directly and pulls the P-loop lysine of ARA7 away from GDP beta-phosphate toward switch II to further destabilize GDP for its release during the transition from the GDP-bound to nucleotide-free intermediates in the nucleotide exchange reaction.	Lysine	90-96	Vacuolar sorting protein 9 (VPS9) domain-containing protein	Arabidopsis thaliana	24-29
32901907-3	2020	KDM2A and KDM2B (Lysine (K)-specific demethylase 2A / B) are histone demethylases modulating the accessibility of ribosomal genes, thereby regulating their transcription.	Lysine	17-23	lysine demethylase 2B	Homo sapiens	10-15
21085684-2	2010	Two classical PLDs, PLD1 and PLD2, contain phosphatidylinositide-binding PX and PH domains and two conserved His-x-Lys-(x)(4)-Asp (HKD) motifs, which are critical for PLD activity.	Lysine	115-118	phospholipase D2	Mus musculus	29-33
10049942-5	1999	The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor-associated polypeptide (KARAP)/DAP12.	Lysine	23-29	transmembrane immune signaling adaptor TYROBP	Homo sapiens	190-195
10049942-5	1999	The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor-associated polypeptide (KARAP)/DAP12.	Lysine	23-29	transmembrane immune signaling adaptor TYROBP	Homo sapiens	197-202
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	NLR family, pyrin domain containing 3	Mus musculus	230-235
15539285-3	1999	The results of this study, which were in agreement with the results of earlier experiments in our laboratory, showed that feeding a low-fat, cholesterol-free, semipurified amino acid diet enriched with Lys + Met to rabbits caused a marked increase in serum total and low density lipoprotein cholesterol and apolipoprotein B levels, whereas a similar diet enriched in essential ketogenic amino acids (EketoAA) resulted in a more moderate increase in these parameters.	Lysine	202-205	apolipoprotein B	Oryctolagus cuniculus	307-323
20822186-4	2010	Presented here is a mass spectrometric immunoassay method for quantitative determination of beta-2-microglobulin, an established biomarker used in the diagnosis of active rheumatoid arthritis and kidney disease, and its structural variant, cleaved at and deficient in lysine-58 (DeltaK58-b2m).	Lysine	268-274	beta-2-microglobulin	Homo sapiens	92-112
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	NLR family, pyrin domain containing 3	Mus musculus	230-235
20716525-3	2010	The KMT2 family of SET domain methyltransferases, typified by mixed lineage leukemia protein-1 (MLL1), is responsible for histone H3 lysine 4 methylation, a marker of active genes.	Lysine	133-139	lysine methyltransferase 2A	Homo sapiens	96-100
10331647-3	1999	ATP, produced by glucose metabolism, competes with cADPR for the binding site, Lys-129, of CD38, resulting in the inhibition of the hydrolysis of cADPR and thereby causing cADPR accumulation in beta-cells.	Lysine	79-82	CD38 molecule	Homo sapiens	91-95
32774499-0	2020	Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2.	Lysine	19-25	lysine methyltransferase 5C	Homo sapiens	127-135
10022840-4	1999	PU.1-Pip interaction is shown to be template directed and involves two distinct protein-protein interaction surfaces: (i) the ets and IRF DNA-binding domains; and (ii) the phosphorylated PEST region of PU.1 and a lysine-requiring putative alpha-helix in Pip.	Lysine	213-219	Spi-1 proto-oncogene	Homo sapiens	0-4
32774499-2	2020	The aberrant trimethylation of histone H4 at lysine 20 (H4K20) has been implicated in carcinogenesis.	Lysine	45-51	H4 clustered histone 6	Homo sapiens	31-41
20944745-8	2010	We show that xnd-1 functions independently of genes required for X chromosome-specific gene silencing, revealing a novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1 exerts its effects on COs, at least in part, by modulating levels of H2A lysine 5 acetylation.	Lysine	288-294	X chromosome NonDisjunction factor	Caenorhabditis elegans	13-18
32727878-7	2020	We observed that K308, one of the Lys residues for NS5A ISGylation, is located within the binding region of cyclophilin A (CypA), which is the critical host factor for HCV replication.	Lysine	34-37	peptidylprolyl isomerase A	Homo sapiens	123-127
20944745-8	2010	We show that xnd-1 functions independently of genes required for X chromosome-specific gene silencing, revealing a novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1 exerts its effects on COs, at least in part, by modulating levels of H2A lysine 5 acetylation.	Lysine	288-294	X chromosome NonDisjunction factor	Caenorhabditis elegans	209-214
20569236-5	2010	Short-term p16 expression increases the amount of histone H3 trimethylated on lysine 27 (H3K27) bound to the hTERT promoter, resulting in transcriptional silencing, likely mediated by polycomb complexes.	Lysine	78-84	telomerase reverse transcriptase	Homo sapiens	109-114
9862972-7	1999	The lysine residue responsible for this interaction is K80 which is conserved in all NF-kappaB/Rel/Dorsal molecules.	Lysine	4-10	keratin 80	Homo sapiens	55-58
32817139-3	2020	KDM6A physically associates with histone H3 lysine 4 monomethyltransferases MLL3 (KMT2C) and MLL4 (KMT2D).	Lysine	44-50	lysine methyltransferase 2D	Homo sapiens	99-104
10736626-2	1999	Hypusine is formed by the transfer of the butylamine portion from spermidine to the epsilon-amino group of a specific lysine residue of eIF-5A precursor and the subsequent hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety.	Lysine	118-124	eukaryotic translation initiation factor 5A	Homo sapiens	136-142
32520409-2	2020	Acyl-CoA synthetase family member 3 (ACSF3), which is involved in the regulation of fatty acid metabolism, was predicted to contain lysine acetylation sites related to the mitochondrial deacetylase sirtuin 3 (SIRT3).	Lysine	132-138	sirtuin 3	Mus musculus	209-214
9875639-8	1998	Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production.	Lysine	267-275	interferon gamma	Rattus norvegicus	0-16
20855965-1	2010	HP1 is a conserved prototype protein that plays an essential role in heterochromatin formation and epigenetic gene silencing through its interaction with histone methyltransferase enzymes (HMTases) and the histone H3 at lysine 9 (H3-MeK9).	Lysine	220-226	chromobox 5	Homo sapiens	0-3
32139900-8	2020	In addition, lysine 418 (K418) and lysine 249 (K249) were shown to be of critical importance in regulating PARP1 ubiquitination and degradation by WWP2.	Lysine	13-19	poly (ADP-ribose) polymerase 1	Rattus norvegicus	107-112
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	53-56	ring finger protein 187	Homo sapiens	85-91
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	ring finger protein 187	Homo sapiens	85-91
20852630-5	2010	Stimulation of the MEK/ERK pathway strongly promoted Lys 63-linked ubiquitylation of RACO-1, which antagonized Lys 48-linked degradative auto-ubiquitylation of the same Lys residues.	Lysine	111-114	ring finger protein 187	Homo sapiens	85-91
9799487-7	1998	In one loop conformation, the conserved Lys 421 can form an intersubunit salt bridge as observed in the muscle PK crystal structure.	Lysine	40-43	pyruvate kinase PKLR	Oryctolagus cuniculus	111-113
9846894-10	1998	These findings, combined with the results on tau chemical modifications suggest that the reactive lysine residues within functional domains on tau, e.g., those of the repetitive binding motifs, were affected by these modifications.	Lysine	98-104	microtubule associated protein tau	Homo sapiens	143-146
32139900-8	2020	In addition, lysine 418 (K418) and lysine 249 (K249) were shown to be of critical importance in regulating PARP1 ubiquitination and degradation by WWP2.	Lysine	35-41	poly (ADP-ribose) polymerase 1	Rattus norvegicus	107-112
9846896-4	1998	Like the glycoxidation products, N(epsilon)-(carboxymethyl)lysine (CML) and glyoxal-lysine dimer (GOLD) which are formed on reaction of glyoxal with protein, CEL and MOLD increase in lens proteins and skin collagen with age.	Lysine	59-65	carboxyl ester lipase	Homo sapiens	158-161
32345914-0	2020	Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia via attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription.	Lysine	94-100	lysine methyltransferase 2A	Homo sapiens	11-15
9797363-10	1998	CONCLUSIONS: Deletion at codon 579 (Asp) in the juxtamembrane domain of the c-kit gene is a novel gain-of-function mutation other than the region between Lys-550 and Val-560.	Lysine	154-157	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	76-81
20558618-2	2010	H3K4 (histone H3 lysine 4) methylation by the SET domain of the trithorax-group protein MLL (mixed-lineage leukemia) is important for the control of homeobox (HOX) gene expression during development.	Lysine	17-23	lysine methyltransferase 2A	Homo sapiens	88-91
20558618-4	2010	MLL fusion proteins associated with human leukemia contain the menin interaction peptide and frequently recruit H3K79 (histone H3 lysine 79) methylation activity.	Lysine	130-136	lysine methyltransferase 2A	Homo sapiens	0-3
32345914-1	2020	Mixed lineage leukemia 1 (MLL1)-mediated histone H3 lysine 4 trimethylation (H3K4me3) of a subset of genes has been linked to the transcriptional activation critical for synaptic plasticity, but its potential contribution to neuropathic allodynia development remains poorly explored.	Lysine	52-58	lysine methyltransferase 2A	Homo sapiens	0-24
20698491-1	2010	In the manufacture of the antibody-drug conjugate Trastuzumab-DM1 (T-DM1), the lysine residues on the antibody trastuzumab (Tmab) are modified to form the intermediate Tmab-MCC (T-MCC) and then conjugated with the drug DM1.	Lysine	79-85	immunoglobulin heavy diversity 1-7	Homo sapiens	62-65
9756909-7	1998	The PML mutant with Lys to Arg substitutions in all three sites is expressed normally, but cannot be sentrinized.	Lysine	20-23	PML nuclear body scaffold	Homo sapiens	4-7
20698491-1	2010	In the manufacture of the antibody-drug conjugate Trastuzumab-DM1 (T-DM1), the lysine residues on the antibody trastuzumab (Tmab) are modified to form the intermediate Tmab-MCC (T-MCC) and then conjugated with the drug DM1.	Lysine	79-85	immunoglobulin heavy diversity 1-7	Homo sapiens	69-72
32345914-1	2020	Mixed lineage leukemia 1 (MLL1)-mediated histone H3 lysine 4 trimethylation (H3K4me3) of a subset of genes has been linked to the transcriptional activation critical for synaptic plasticity, but its potential contribution to neuropathic allodynia development remains poorly explored.	Lysine	52-58	lysine methyltransferase 2A	Homo sapiens	26-30
20698491-1	2010	In the manufacture of the antibody-drug conjugate Trastuzumab-DM1 (T-DM1), the lysine residues on the antibody trastuzumab (Tmab) are modified to form the intermediate Tmab-MCC (T-MCC) and then conjugated with the drug DM1.	Lysine	79-85	immunoglobulin heavy diversity 1-7	Homo sapiens	69-72
32867667-4	2021	The MLL/KMT2 family of histone methyltransferases specifically methylate histone H3 at lysine 4.	Lysine	87-93	lysine methyltransferase 2A	Homo sapiens	4-7
21171714-7	2010	With poly-L-lysine as the underlying layer, biologically significant differences (greater than twofold) in the expression of VWF, VEGFR, VEGFA, endoglin, and ICAM1 were observed among the three glycosaminoglycans.	Lysine	5-18	endoglin	Homo sapiens	144-152
9722668-6	1998	Regions of skeletal muscle myosin containing the highly reactive residues Cys 707 (SH1), Cys 697 (SH2), and lysine 83 (RLR) dramatically alter their local conformation when myosin hydrolyzes ATP, and these changes may reflect formation of a series of transient intermediates during ATP hydrolysis.	Lysine	108-114	myosin heavy chain 14	Homo sapiens	27-33
32854201-2	2020	In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of 68Ga-labeled DOTA-conjugated peptides and peptidomimetics.	Lysine	43-46	mevalonate kinase	Mus musculus	48-51
9765602-5	1998	Several Lys-Ser-Gly repeats are present in the basic region of the hnRNP C proteins.	Lysine	8-11	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	67-74
9712037-5	1998	Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors.	Lysine	78-84	dynein light chain Tctex-type 1	Homo sapiens	0-7
20534001-3	2010	The selective 5-HT(2B)R antagonist 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-B]indole (LY 266097; 0.16 mg/kg, i.p.)	Lysine	128-130	5-hydroxytryptamine receptor 2B	Rattus norvegicus	14-21
9712037-5	1998	Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors.	Lysine	78-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	162-165
20930520-12	2010	A subsequent study revealed that HOTAIR is overexpressed in approximately one quarter of human breast cancers, directing PRC2 to approximately 800 ectopic sites in the genome, which leads to histone H3 lysine 27 trimethylation and changes in gene expression[4].	Lysine	202-208	HOX transcript antisense RNA	Homo sapiens	33-39
32814769-1	2020	The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined.	Lysine	47-53	lysine methyltransferase 2A	Homo sapiens	120-123
9675242-4	1998	These analyses showed that five distinct cytochrome c derivatives had been produced which were modified at the specific Lys residues including Lys8, Lys25, Lys72, Lys86 or Lys87, respectively.	Lysine	120-123	cytochrome c, somatic	Equus caballus	41-53
32639142-1	2020	Acetylation of alpha-tubulin at conserved lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellular activities.	Lysine	42-48	tubulin alpha 1b	Homo sapiens	15-28
9668041-4	1998	Injection of mRNA coding for the wild type Akt kinase was less effective in stimulating GVBD, whereas Akt bearing a lysine mutation in the catalytic domain that abolishes the kinase activity had no effect.	Lysine	116-122	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	102-105
20601429-9	2010	Three matriptase recognition sites were identified in ASIC1 (Arg-145, Lys-185, and Lys-384).	Lysine	70-73	acid sensing ion channel subunit 1	Homo sapiens	54-59
20601429-9	2010	Three matriptase recognition sites were identified in ASIC1 (Arg-145, Lys-185, and Lys-384).	Lysine	83-86	acid sensing ion channel subunit 1	Homo sapiens	54-59
32875102-2	2020	Here, we showed that loss of the m6A reader YTH-domain family 2 (YTHDF2) promoted demethylation of histone H3 lysine-27 trimethylation (H3K27me3), which led to enhanced production of proinflammatory cytokines and facilitated the deposition of m6A cotranscriptionally.	Lysine	110-116	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	44-63
20538595-5	2010	Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and Lys-333, and a phosphorylation site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, and MHC class II expression.	Lysine	39-45	class II major histocompatibility complex transactivator	Homo sapiens	143-148
20538595-5	2010	Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and Lys-333, and a phosphorylation site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, and MHC class II expression.	Lysine	39-45	class II major histocompatibility complex transactivator	Homo sapiens	171-176
20538595-5	2010	Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and Lys-333, and a phosphorylation site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, and MHC class II expression.	Lysine	56-59	class II major histocompatibility complex transactivator	Homo sapiens	143-148
20538595-5	2010	Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and Lys-333, and a phosphorylation site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, and MHC class II expression.	Lysine	65-68	class II major histocompatibility complex transactivator	Homo sapiens	143-148
20538595-5	2010	Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and Lys-333, and a phosphorylation site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, and MHC class II expression.	Lysine	65-68	class II major histocompatibility complex transactivator	Homo sapiens	143-148
9660787-3	1998	To establish how it is glycosylated, SKP1 labeled with [3H]Fuc was purified to homogeneity and digested with endo-Lys-C.	Lysine	114-117	S-phase kinase associated protein 1	Homo sapiens	37-41
9670929-3	1998	One soluble KIR2D, derived from an inhibitory receptor with a long cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.	Lysine	149-155	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	85-92
32875102-2	2020	Here, we showed that loss of the m6A reader YTH-domain family 2 (YTHDF2) promoted demethylation of histone H3 lysine-27 trimethylation (H3K27me3), which led to enhanced production of proinflammatory cytokines and facilitated the deposition of m6A cotranscriptionally.	Lysine	110-116	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	65-71
32758419-4	2020	Blocking CAR ubiquitination by mutating all lysines in the CAR cytoplasmic domain (CARKR) markedly repressed CAR downmodulation by inhibiting lysosomal degradation while enhancing recycling of internalized CARs back to the cell surface.	Lysine	44-51	CXADR pseudogene 1	Homo sapiens	9-12
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Lysine	23-26	general transcription factor 3A L homeolog	Xenopus laevis	68-93
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Lysine	23-26	general transcription factor 3A L homeolog	Xenopus laevis	95-101
20547484-0	2010	The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.	Lysine	39-45	DNA methyltransferase 3 alpha	Homo sapiens	4-10
20671152-2	2010	Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defective immunoglobulin class switching.	Lysine	171-177	PAX interacting protein 1	Homo sapiens	56-60
32758419-4	2020	Blocking CAR ubiquitination by mutating all lysines in the CAR cytoplasmic domain (CARKR) markedly repressed CAR downmodulation by inhibiting lysosomal degradation while enhancing recycling of internalized CARs back to the cell surface.	Lysine	44-51	CXADR pseudogene 1	Homo sapiens	59-62
32758419-4	2020	Blocking CAR ubiquitination by mutating all lysines in the CAR cytoplasmic domain (CARKR) markedly repressed CAR downmodulation by inhibiting lysosomal degradation while enhancing recycling of internalized CARs back to the cell surface.	Lysine	44-51	CXADR pseudogene 1	Homo sapiens	59-62
20551322-5	2010	Here, we demonstrate the sumoylation of NRL in vivo and in vitro, with two small ubiquitin-like modifier (SUMO) molecules attached to the Lys-20 residue.	Lysine	138-141	neural retina leucine zipper gene	Mus musculus	40-43
32675242-5	2020	We identified two lysine residues, 6 and 9, in the first exon of mHtt that are specifically ubiquitinated in striatal and cortical brain tissues of mHtt-transgenic animals.	Lysine	18-24	huntingtin	Mus musculus	65-69
20630764-0	2010	N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.	Lysine	20-26	sirtuin 2	Homo sapiens	63-68
20630764-2	2010	Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel N(epsilon)-modified lysine containing inhibitors against SIRT1 and SIRT2.	Lysine	124-130	sirtuin 2	Homo sapiens	171-176
9605162-0	1998	Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies.	Lysine	76-82	apolipoprotein H	Homo sapiens	6-27
9605162-0	1998	Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies.	Lysine	76-82	apolipoprotein H	Homo sapiens	172-193
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Lysine	197-205	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	4-10
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Lysine	197-205	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	77-83
20714214-4	2010	Myc binding to targets genes depends on the presence of the E-box binding motif and the presence of histone H3K4me3 lysines.	Lysine	116-123	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
9564049-3	1998	In the presence of ATP, hMutSalpha dissociated from mismatched oligonucleotide substrates, and this reaction was attenuated by mutating the conserved lysine in the ATP-binding domains of hMSH6, hMSH2 or both to arginine.	Lysine	150-156	mutS homolog 6	Homo sapiens	187-192
32675242-5	2020	We identified two lysine residues, 6 and 9, in the first exon of mHtt that are specifically ubiquitinated in striatal and cortical brain tissues of mHtt-transgenic animals.	Lysine	18-24	huntingtin	Mus musculus	148-152
32504080-1	2020	Lysinuric protein intolerance (LPI) is an inborn error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallelic pathogenic variants in SLC7A7, which encodes the light subunit of the y+LAT1 transporter.	Lysine	89-95	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	Mus musculus	161-167
9548943-6	1998	Monitoring DMPG-d5 in mixed DMPC/DMPG bilayers revealed a direct electrostatic interaction of DMPG with the protein, where positively charged lysine residues located at the tail domain of myosin provide the necessary sites for the interaction to occur.	Lysine	142-148	myosin heavy chain 14	Homo sapiens	188-194
20547755-4	2010	This interaction is regulated by two competitive posttranslational modifications of HIC1 at lysine 314, promotion by SUMOylation, and inhibition by acetylation.	Lysine	92-98	HIC ZBTB transcriptional repressor 1	Homo sapiens	84-88
32577803-8	2020	In particular, the lysine variant content noticeably increased with tyrosine limitation owing to the downregulation of two carboxypeptidases, i.e., CpB and CpH.	Lysine	19-25	carboxypeptidase B1	Rattus norvegicus	148-151
20516063-3	2010	Here we found that BZLF1 is conjugated at lysine 12 not only by SUMO-1 but also by SUMO-2 and 3.	Lysine	42-48	protein Zta	Human gammaherpesvirus 4	19-24
9541871-5	1998	In some of the newly identified DM domains, the glutamate is changed to a residue that could not function as a proton shuttle and in one instance (Mus musculus spermatid protein TENR) the cysteines are also changed to lysine and serine.	Lysine	218-224	adenosine deaminase domain containing 1 (testis specific)	Mus musculus	178-182
20599721-0	2010	S6K1 is acetylated at lysine 516 in response to growth factor stimulation.	Lysine	22-28	ribosomal protein S6 kinase B1	Homo sapiens	0-4
32094511-6	2020	This mechanism of degradation also required the MCL1 transmembrane domain and distinct MCL1 lysine residues to proceed, suggesting that the components likely act on the MCL1:NOXA complex by associating with it in a specific orientation within the mitochondrial outer membrane.	Lysine	92-98	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	87-91
20599721-3	2010	In addition to phosphorylation, we have recently shown that S6K1 is also targeted by lysine acetylation.	Lysine	85-91	ribosomal protein S6 kinase B1	Homo sapiens	60-64
20599721-4	2010	Here, using tandem mass spectrometry we have mapped acetylation of S6K1 to lysine 516, a site close to the C-terminus of the kinase that is highly conserved amongst vertebrate S6K1 orthologues.	Lysine	75-81	ribosomal protein S6 kinase B1	Homo sapiens	67-71
20599721-4	2010	Here, using tandem mass spectrometry we have mapped acetylation of S6K1 to lysine 516, a site close to the C-terminus of the kinase that is highly conserved amongst vertebrate S6K1 orthologues.	Lysine	75-81	ribosomal protein S6 kinase B1	Homo sapiens	176-180
9507015-6	1998	Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression.	Lysine	17-30	interleukin 1 alpha	Homo sapiens	78-82
32094511-6	2020	This mechanism of degradation also required the MCL1 transmembrane domain and distinct MCL1 lysine residues to proceed, suggesting that the components likely act on the MCL1:NOXA complex by associating with it in a specific orientation within the mitochondrial outer membrane.	Lysine	92-98	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	87-91
9570320-10	1998	The conserved lysine residue (K436) in the helicase motif Ia in the Upf1p was shown to be critical for ATP binding.	Lysine	14-20	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	68-73
32487734-0	2020	Modulation of Human Arylamine N-Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CBP and Sirtuins 1 and 2.	Lysine	64-70	N-acetyltransferase 1	Homo sapiens	20-51
9838244-7	1998	CYP11B2 is polymorphic at this position, encoding arginine or lysine.	Lysine	62-68	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	0-7
20554965-5	2010	Specifically, hepatitis B virus X (HBX) interacted with MAVS and promoted the degradation of MAVS through Lys(136) ubiquitin in MAVS protein, thus preventing the induction of IFN-beta.	Lysine	106-109	X protein	Hepatitis B virus	14-33
20554965-5	2010	Specifically, hepatitis B virus X (HBX) interacted with MAVS and promoted the degradation of MAVS through Lys(136) ubiquitin in MAVS protein, thus preventing the induction of IFN-beta.	Lysine	106-109	X protein	Hepatitis B virus	35-38
32487734-2	2020	Recently, it was reported that NAT1 undergoes lysine acetylation, an important post-translational modification that can regulate protein function.	Lysine	46-52	N-acetyltransferase 1	Homo sapiens	31-35
20442396-0	2010	A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation.	Lysine	44-47	H2B clustered histone 21	Homo sapiens	40-43
20442396-0	2010	A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation.	Lysine	74-77	H2B clustered histone 21	Homo sapiens	40-43
9443739-5	1998	The activities for plasmin of the plasmin inhibitor and bovine pancreatic trypsin inhibitor were reduced by conjugation, presumably because of a sensitive lysine residue in the structure of each of these two peptides.	Lysine	155-161	plasminogen	Bos taurus	19-26
32487734-3	2020	In the current study, we use site-directed mutagenesis to identify K100 and K188 as major sites of lysine acetylation in the NAT1 protein.	Lysine	99-105	N-acetyltransferase 1	Homo sapiens	125-129
9443739-5	1998	The activities for plasmin of the plasmin inhibitor and bovine pancreatic trypsin inhibitor were reduced by conjugation, presumably because of a sensitive lysine residue in the structure of each of these two peptides.	Lysine	155-161	plasminogen	Bos taurus	34-41
20442396-6	2010	We found that H2B ubiquitination is inversely correlated with H3 Lys-79 methylation.	Lysine	65-68	H2B clustered histone 21	Homo sapiens	14-17
20442396-7	2010	Therefore, we propose that a catalytic and inhibitory loop mechanism may better describe the cross-talk relationship between H2B ubiquitination and H3 Lys-79 methylation.	Lysine	151-154	H2B clustered histone 21	Homo sapiens	125-128
32694502-0	2020	Author Correction: A methylated lysine is a switch point for conformational communication in the chaperone Hsp90.	Lysine	32-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-112
9608659-1	1998	Gag p19 protein (MA) of the transformation-defective Rous sarcoma virus mutant, tdPH2010, has a point mutation at nucleotide 376 (G to A) that results in an amino-acid change at residue 126 of p19 (Glu to Lys).	Lysine	205-208	interleukin 23 subunit alpha	Homo sapiens	4-7
9608659-1	1998	Gag p19 protein (MA) of the transformation-defective Rous sarcoma virus mutant, tdPH2010, has a point mutation at nucleotide 376 (G to A) that results in an amino-acid change at residue 126 of p19 (Glu to Lys).	Lysine	205-208	interleukin 23 subunit alpha	Homo sapiens	193-196
32634241-8	2020	Mechanistically, we uncover an epigenetic barrier to efficient cooperation; mIDH1/2 expression is associated with high global histone 3 lysine 79 dimethylation (H3K79me2) levels, whereas global H3K79me2 is obligate low in KMT2A-rearranged AML.	Lysine	136-142	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	76-83
9405486-8	1997	Lys to Ala or Lys to Arg substitution at Lys329 totally abolished covalent enzyme-substrate intermediate formation and deoxyhypusine synthesis activity, indicating that Lys329 is the unique site for the enzyme intermediate and that it is absolutely required for deoxyhypusine synthesis in the eukaryotic translation initiation factor 5A precursor.	Lysine	0-3	eukaryotic translation initiation factor 5A	Homo sapiens	293-336
9405486-8	1997	Lys to Ala or Lys to Arg substitution at Lys329 totally abolished covalent enzyme-substrate intermediate formation and deoxyhypusine synthesis activity, indicating that Lys329 is the unique site for the enzyme intermediate and that it is absolutely required for deoxyhypusine synthesis in the eukaryotic translation initiation factor 5A precursor.	Lysine	14-17	eukaryotic translation initiation factor 5A	Homo sapiens	293-336
20427269-6	2010	Valproate treatment induced binding of Ets-1 and Ets-2 to the FOXP3 promoter and acted positively on its expression, by increasing the acetylation of histone H4 lysines.	Lysine	161-168	ETS proto-oncogene 1, transcription factor	Homo sapiens	39-44
20427269-6	2010	Valproate treatment induced binding of Ets-1 and Ets-2 to the FOXP3 promoter and acted positively on its expression, by increasing the acetylation of histone H4 lysines.	Lysine	161-168	ETS proto-oncogene 2, transcription factor	Homo sapiens	49-54
32459350-2	2020	Here we discover an HRP2-DPF3a-BAF epigenetic pathway that coordinates methylated histone H3 lysine 36 (H3K36me) and ATP-dependent chromatin remodeling to regulate chromatin dynamics and gene transcription during myogenic differentiation.	Lysine	93-99	b-associated fitness	Mus musculus	31-34
20418916-0	2010	LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription.	Lysine	42-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-63
20418916-2	2010	We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3.	Lysine	46-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	16-19
20418916-2	2010	We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3.	Lysine	119-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	16-19
9396728-2	1997	The covalent complex has been prepared by introducing a disulphide bond between Cys-1 of P21 and Lys-13 of Mp, previously modified with a thiol-containing reagent.	Lysine	97-100	H3 histone pseudogene 16	Homo sapiens	89-92
32435793-6	2020	Blocking ubiquitination of Smo by an E1 ligase inhibitor or by mutating two lysine residues in intracellular loop three causes Smo to aberrantly accumulate in cilia without pathway activation.	Lysine	76-82	smoothened, frizzled class receptor	Homo sapiens	27-30
9502155-3	1997	Fragmentation allowed the resolution of the variants arising from the cyclization of glutamine to pyroglutamate at the amino-terminus of the light and heavy chains (Fab-pE/Q variants) from the variants resulting from the processing of the carboxy-terminal lysine residues of the heavy chains (Fc-Lys variants).	Lysine	256-262	FA complementation group B	Homo sapiens	165-168
9502155-3	1997	Fragmentation allowed the resolution of the variants arising from the cyclization of glutamine to pyroglutamate at the amino-terminus of the light and heavy chains (Fab-pE/Q variants) from the variants resulting from the processing of the carboxy-terminal lysine residues of the heavy chains (Fc-Lys variants).	Lysine	296-299	FA complementation group B	Homo sapiens	165-168
20577214-5	2010	Here we show that SphK1 and the production of S1P is necessary for lysine-63-linked polyubiquitination of RIP1, phosphorylation of IkappaB kinase and IkappaBalpha, and IkappaBalpha degradation, leading to NF-kappaB activation.	Lysine	67-73	sphingosine kinase 1	Homo sapiens	18-23
32247936-2	2020	In this study, we revealed the secretion mechanism of transforming growth factor beta-induced protein (TGFBIp) that was recently identified as a therapeutic target for sepsis, and designed TGFBIp acetylation inhibitory peptide (TAIP) that suppresses acetylation of lysine 676 in TGFBIp.	Lysine	265-271	transforming growth factor, beta induced	Mus musculus	103-109
20577214-5	2010	Here we show that SphK1 and the production of S1P is necessary for lysine-63-linked polyubiquitination of RIP1, phosphorylation of IkappaB kinase and IkappaBalpha, and IkappaBalpha degradation, leading to NF-kappaB activation.	Lysine	67-73	receptor interacting serine/threonine kinase 1	Homo sapiens	106-110
9392078-3	1997	Previously, the lys80 mutations, reducing the lysine repression and increasing the production of lysine, were interpreted as impairing a repressor of LYS genes expression.	Lysine	46-52	Mks1p	Saccharomyces cerevisiae S288C	16-21
9392078-3	1997	Previously, the lys80 mutations, reducing the lysine repression and increasing the production of lysine, were interpreted as impairing a repressor of LYS genes expression.	Lysine	97-103	Mks1p	Saccharomyces cerevisiae S288C	16-21
9392078-4	1997	In order to understand the role of Lys80p in the control of the lysine pathway, we have analysed the effects of mutations epistatic to lys80 mutations.	Lysine	64-70	Mks1p	Saccharomyces cerevisiae S288C	35-41
20403980-4	2010	The results showed that blockade of PKB activity caused significant reduction of CK release and cell death, a benefit that was as potent as ischaemic preconditioning and could be reproduced by blockade of phosphatidylinositol 3-kinase (PI-3K) with wortmannin and LY 294002.	Lysine	263-265	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	205-234
32247936-2	2020	In this study, we revealed the secretion mechanism of transforming growth factor beta-induced protein (TGFBIp) that was recently identified as a therapeutic target for sepsis, and designed TGFBIp acetylation inhibitory peptide (TAIP) that suppresses acetylation of lysine 676 in TGFBIp.	Lysine	265-271	transforming growth factor, beta induced	Mus musculus	189-195
9392078-5	1997	The effects of lys80 mutations on LYS genes expression were dependent on the integrity of the activation system (Lys14p and alpha AASA).	Lysine	34-37	Mks1p	Saccharomyces cerevisiae S288C	15-20
32185890-1	2020	HLA-DRB3*03:39 differs from HLA-DRB3*03:01:01 by a single nucleotide substitution in codon 22 (Glutamic acid to Lysine).	Lysine	112-118	major histocompatibility complex, class II, DR beta 3	Homo sapiens	0-8
9392078-6	1997	The increased production of lysine in lys80 mutants appeared to result from an improvement of the metabolic flux through the pathway and was correlated to an increase of the alpha-ketoglutarate pool and of the level of several enzymes of the tricarboxylic acid cycle.	Lysine	28-34	Mks1p	Saccharomyces cerevisiae S288C	38-43
9341155-7	1997	Lysines 45, 89, 92, and 96 were derivatized only in monomeric GNMT, suggesting that modification of these residues resulted in GNMT dissociation.	Lysine	0-7	glycine N-methyltransferase	Rattus norvegicus	62-66
9341155-7	1997	Lysines 45, 89, 92, and 96 were derivatized only in monomeric GNMT, suggesting that modification of these residues resulted in GNMT dissociation.	Lysine	0-7	glycine N-methyltransferase	Rattus norvegicus	127-131
20398676-8	2010	The interaction between ACT1 and ACT4 or between ACT2 and ACT3 generates a threonine binding site and a lysine binding site at each interface, making a total of eight regulatory sites per dimer and allowing a fine-tuning of the AK activity by the end products, threonine and lysine.	Lysine	104-110	C-C motif chemokine ligand 4	Homo sapiens	49-53
20398676-8	2010	The interaction between ACT1 and ACT4 or between ACT2 and ACT3 generates a threonine binding site and a lysine binding site at each interface, making a total of eight regulatory sites per dimer and allowing a fine-tuning of the AK activity by the end products, threonine and lysine.	Lysine	275-281	C-C motif chemokine ligand 4	Homo sapiens	49-53
20427762-6	2010	We identified an evolutionary-unique lysine residue in Cbeta, central to murine TCR function.	Lysine	37-43	T cell receptor alpha variable 6-3	Mus musculus	80-83
20483785-5	2010	Five essential amino acid exchanges were identified in the TCRbeta C region, with exchange of a glutamic acid (human) for a basic lysine (mouse) at position 18 of the C region, being most important.	Lysine	130-136	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	59-66
20351170-2	2010	The SUMO E3 ligase PIAS1 enhances SUMO conjugation to SATB1 lysine-744, and this modification regulates caspase-6 mediated cleavage of SATB1 at promyelocytic leukemia nuclear bodies (PML NBs).	Lysine	60-66	protein inhibitor of activated STAT 1	Homo sapiens	19-24
20307995-2	2010	This mutation results from the substitution of asparagine (AAC) by lysine (AAA) at codon 103 of a non-mature (signal peptide-containing) leptin and corresponds to the N82K mutation in the mature protein.	Lysine	67-73	leptin	Homo sapiens	137-143
20421743-1	2010	Heterochromatin Protein 1 (HP1) is a transcriptional repressor that directly binds to the methylated lysine 9 residue of histone H3 (H3K9me), which is a hallmark histone modification for transcriptionally silenced heterochromatin.	Lysine	101-107	chromobox 5	Homo sapiens	0-25
20421743-1	2010	Heterochromatin Protein 1 (HP1) is a transcriptional repressor that directly binds to the methylated lysine 9 residue of histone H3 (H3K9me), which is a hallmark histone modification for transcriptionally silenced heterochromatin.	Lysine	101-107	chromobox 5	Homo sapiens	27-30
20470363-10	2010	Additionally we examined co-localization of GLT25D1 with MBL and lysyl hydroxylase 3 (LH3, PLOD3), which is a protein able to catalyze hydroxylation of lysine residues before they can be glycosylated.	Lysine	152-158	mannose binding lectin 2	Homo sapiens	57-60
20470363-10	2010	Additionally we examined co-localization of GLT25D1 with MBL and lysyl hydroxylase 3 (LH3, PLOD3), which is a protein able to catalyze hydroxylation of lysine residues before they can be glycosylated.	Lysine	152-158	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	65-84
20470363-10	2010	Additionally we examined co-localization of GLT25D1 with MBL and lysyl hydroxylase 3 (LH3, PLOD3), which is a protein able to catalyze hydroxylation of lysine residues before they can be glycosylated.	Lysine	152-158	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	86-89
20470363-10	2010	Additionally we examined co-localization of GLT25D1 with MBL and lysyl hydroxylase 3 (LH3, PLOD3), which is a protein able to catalyze hydroxylation of lysine residues before they can be glycosylated.	Lysine	152-158	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	91-96
20074640-5	2010	However, we demonstrate that a region consisting of the ERK1/2 docking domain, ERK1/2 phosphorylation sites and either of the two potential ubiquitin-acceptor lysine residues is sufficient to allow poly-ubiquitination and turnover of BIM.	Lysine	159-165	BCL2 like 11	Homo sapiens	234-237
20194622-4	2010	By studying the polyubiquitination of Sic1 by the E2 protein Cdc34 and the RING E3 Skp1/Cul1/F-box (SCF) protein, we now demonstrate that in addition to E2/E3-mediated positioning, proximal amino acids surrounding the lysine residues in Sic1 and Ub are critical for ubiquitination.	Lysine	218-224	cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1	Saccharomyces cerevisiae S288C	38-42
20398220-5	2010	Finally, a COPI binding domain swap was used to demonstrate that substitution of the lysine-rich transmembrane helix 1 with the COPI binding portion of the p23 adaptor cytoplasmic tail results in a mutant that displays full wild-type activity.	Lysine	85-91	prostaglandin E synthase 3	Homo sapiens	156-159
20931757-2	2010	The immunoconjugates were prepared by linking Fab" to lysine-69 of LDM apoprotein by SPDP, LCSPDP, SMBS or SSMPB as the intermediate drug linkers.	Lysine	54-60	FA complementation group B	Homo sapiens	46-49
20398922-5	2010	While RAG1 binding was detected only at regions containing recombination signal sequences, RAG2 binds at thousands of sites in the genome containing histone 3 trimethylated at lysine 4.	Lysine	176-182	recombination activating 2	Homo sapiens	91-95
20331966-8	2010	Chromatin immunoprecipitation (ChIP) experiments show that Eco1 facilitates the demethylation of lysine 4 of histone H3.	Lysine	97-103	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	59-63
20189851-0	2010	First detection of Hb Hornchurch (beta43(CD2) Glu-Lys) in a Chinese.	Lysine	50-53	CD2 molecule	Homo sapiens	41-44
20393566-5	2010	Enforced expression of HOTAIR in epithelial cancer cells induced genome-wide re-targeting of Polycomb repressive complex 2 (PRC2) to an occupancy pattern more resembling embryonic fibroblasts, leading to altered histone H3 lysine 27 methylation, gene expression, and increased cancer invasiveness and metastasis in a manner dependent on PRC2.	Lysine	223-229	HOX transcript antisense RNA	Homo sapiens	23-29
19887450-5	2010	In addition, we identify six essential residues Tyr-87, Ile-97, Arg-99, Asn-103, Lys-105, and Lys-108 that define a compact HA-binding surface on Lyve-1, encompassing the epitope for an adhesion-blocking monoclonal antibody 3A, in an analogous position to the HA-binding surface in CD44.	Lysine	81-84	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	146-152
19887450-5	2010	In addition, we identify six essential residues Tyr-87, Ile-97, Arg-99, Asn-103, Lys-105, and Lys-108 that define a compact HA-binding surface on Lyve-1, encompassing the epitope for an adhesion-blocking monoclonal antibody 3A, in an analogous position to the HA-binding surface in CD44.	Lysine	94-97	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	146-152
20332119-5	2010	The presence of a single lysine residue at specific positions within the TCRalpha TM domain abolishes its oligomerization and causes its rapid degradation.	Lysine	25-31	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	73-81
20071582-11	2010	While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction.	Lysine	50-53	mitochondrial antiviral signaling protein	Homo sapiens	117-121
20334638-0	2010	Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.	Lysine	28-34	euchromatic histone lysine methyltransferase 1	Homo sapiens	64-68
20334638-0	2010	Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.	Lysine	28-34	euchromatic histone lysine methyltransferase 1	Homo sapiens	69-74
20334638-5	2010	We found that the histone lysine methyltransferases G9a/KMT1C and Glp1/KMT1D methylate H1.2 in vitro and in vivo, and we mapped this novel site to lysine 187 (H1.2K187) in the C-terminus of H1.	Lysine	26-32	euchromatic histone lysine methyltransferase 1	Homo sapiens	66-70
20334638-5	2010	We found that the histone lysine methyltransferases G9a/KMT1C and Glp1/KMT1D methylate H1.2 in vitro and in vivo, and we mapped this novel site to lysine 187 (H1.2K187) in the C-terminus of H1.	Lysine	26-32	euchromatic histone lysine methyltransferase 1	Homo sapiens	71-76
20237569-7	2010	Finally, the comparison of Ca(2+)-binding CUB domains and the low-density lipoprotein (LDL) receptor-type A modules suggests that the electrostatic pairing of a basic ligand arginine/lysine residue with Ca(2+)-coordinating acidic aspartates/glutamates is a common theme of Ca(2+)-dependent ligand-receptor interactions.	Lysine	183-189	low density lipoprotein receptor	Homo sapiens	62-100
20083119-9	2010	We further observed that substrate binding proteins with multiple substrate acceptor lysines have a larger distance range between the substrate and the E2 as compared with beta-TrCP1, with only one acceptor lysine.	Lysine	85-91	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	172-182
20148560-1	2010	LSD1 is a flavin-dependent histone demethylase that oxidatively removes methyl groups from Lys-4 of histone H3.	Lysine	91-94	methyl-CpG binding domain protein 2	Homo sapiens	35-46
20203611-7	2010	Mass spectrometry of mitochondrial proteins shows that long-chain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated at lysine 42 in the absence of SIRT3.	Lysine	125-131	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	55-95
20203611-7	2010	Mass spectrometry of mitochondrial proteins shows that long-chain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated at lysine 42 in the absence of SIRT3.	Lysine	125-131	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	97-101
20148947-8	2010	A systematic analysis of mutant Mhr1 proteins revealed that Asp69 is involved in Mg(2+)-dependent DNA binding, and that multiple Lys and Arg residues located around Trp71 and Trp165 are involved in the DNA-binding activity of Mhr1.	Lysine	129-132	Mhr1p	Saccharomyces cerevisiae S288C	32-36
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	33-40	inhibitor of growth family member 1	Homo sapiens	60-63
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	33-40	inhibitor of growth family member 1	Homo sapiens	171-174
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	33-40	tumor susceptibility 101	Homo sapiens	201-207
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	136-143	inhibitor of growth family member 1	Homo sapiens	60-63
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	136-143	inhibitor of growth family member 1	Homo sapiens	171-174
20004458-2	2010	In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor.	Lysine	136-143	tumor susceptibility 101	Homo sapiens	201-207
20004458-4	2010	The combined mutations of the two lysines and the late-domain-like sequences in p33 reduced replication of a replicon RNA of Tomato bushy stunt virus in yeast model host, in plant protoplasts, and plant leaves, suggesting that p33-Vps23p ESCRT protein interaction affects tombusvirus replication.	Lysine	34-41	inhibitor of growth family member 1	Homo sapiens	80-83
20004458-4	2010	The combined mutations of the two lysines and the late-domain-like sequences in p33 reduced replication of a replicon RNA of Tomato bushy stunt virus in yeast model host, in plant protoplasts, and plant leaves, suggesting that p33-Vps23p ESCRT protein interaction affects tombusvirus replication.	Lysine	34-41	inhibitor of growth family member 1	Homo sapiens	227-230
20004458-4	2010	The combined mutations of the two lysines and the late-domain-like sequences in p33 reduced replication of a replicon RNA of Tomato bushy stunt virus in yeast model host, in plant protoplasts, and plant leaves, suggesting that p33-Vps23p ESCRT protein interaction affects tombusvirus replication.	Lysine	34-41	ubiquitin-binding ESCRT-I subunit protein STP22	Saccharomyces cerevisiae S288C	231-237
20038579-3	2010	Tumor necrosis factor receptor-associated factors 2 and 6 (TRAF2 and -6) act as the ubiquitin E3 ligases to mediate Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue in vivo and in vitro.	Lysine	116-119	TNF receptor-associated factor 2	Mus musculus	59-71
20038579-3	2010	Tumor necrosis factor receptor-associated factors 2 and 6 (TRAF2 and -6) act as the ubiquitin E3 ligases to mediate Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue in vivo and in vitro.	Lysine	162-165	TNF receptor-associated factor 2	Mus musculus	59-71
19828345-7	2010	In addition, a mutant LDLR, which has the three lysines in the intracellular domain substituted with arginines, was also degraded by D374Y-PCSK9.	Lysine	48-55	low density lipoprotein receptor	Homo sapiens	22-26
19828345-7	2010	In addition, a mutant LDLR, which has the three lysines in the intracellular domain substituted with arginines, was also degraded by D374Y-PCSK9.	Lysine	48-55	proprotein convertase subtilisin/kexin type 9	Homo sapiens	139-144
19920145-7	2010	A second ligand receptor-binding site involved Lys(134), with alanine substitution leading to a protein that still binds GPL, but is unable to recruit the second receptor subunit and the subsequent signaling pathways.	Lysine	47-50	interleukin 31 receptor A	Homo sapiens	121-124
19913553-3	2010	Here, we study one facet of this CHIP-mediated turnover by determining the lysine residues on human Hsp70 and Hsp90 ubiquitinated by CHIP.	Lysine	75-81	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
19913553-5	2010	Six such ubiquitination sites were identified on Hsp70 (K325, K451, K524, K526, K559, and K561) and 13 ubiquitinated lysine residues were found on Hsp90 (K107, K204, K219, K275, K284, K347, K399, K477, K481, K538, K550, K607, and K623).	Lysine	117-123	heat shock protein 90 alpha family class A member 1	Homo sapiens	147-152
20098713-2	2010	SUMO is covalently attached to lysines in target proteins via an enzymatic cascade which consists of E1 and E2, SUMO activating and conjugating enzymes.	Lysine	31-38	small nucleolar RNA, H/ACA box 73A	Homo sapiens	101-110
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Lysine	98-101	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
21394217-7	2010	The XPD diplotypes were coded as the combination of two of the following haplotypes: haplotype A=(Lys)751A/(Asp) 312G; B=(Gln)751C/(Asn)312A; C=(Lys)751A/(Asn)312A; and D=(Gln)751C/(Asp)312G.	Lysine	145-148	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
19864419-7	2010	Endogenous and overexpressed Nedd4 polyubiquitinate Spry2 via Lys(48) on ubiquitin and decrease its stability.	Lysine	62-65	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	29-34
19846531-9	2010	When three lysine sites at positions 101, 103, and 104 of WNVCp were replaced with alanine, MKRN1-mediated ubiquitination and degradation of the mutant were significantly inhibited, suggesting that these sites are required for the ubiquitination.	Lysine	11-17	makorin ring finger protein 1	Homo sapiens	92-97
19855092-2	2010	Previous work has demonstrated the importance of posttranslational modifications, such as proline hydroxylation and lysine hydroxylation/glycosylation, in adiponectin oligomerization, secretion, and function.	Lysine	116-122	adiponectin, C1Q and collagen domain containing	Mus musculus	155-166
19942853-6	2009	Interestingly, Lag2 is itself neddylated in vivo on a lysine adjacent to this N-terminal-binding site.	Lysine	54-60	Lag2p	Saccharomyces cerevisiae S288C	15-19
19906198-1	2009	The C1q binding epicentre on IgG molecules involves residues Asp(270), Lys(322), Pro(329) and Pro(331) in the C(H)2 domain.	Lysine	71-74	complement C1q A chain	Homo sapiens	4-7
19896110-4	2009	An important recent observation has been the dependence of cortical neuronal migration upon acetylation of alpha-tubulin at lysine 40 by the histone acetyltransferase Elongator complex.	Lysine	124-130	tubulin alpha 1b	Homo sapiens	107-120
19834512-3	2009	Combined with the results of biochemical analysis, the complex structure indicates that DNMT3A recognizes the unmethylated state of lysine 4 in histone H3.	Lysine	132-138	DNA methyltransferase 3 alpha	Homo sapiens	88-94
19706600-0	2009	Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation.	Lysine	75-81	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	36-40
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	15-21	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	54-58
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	15-21	TNF receptor associated factor 6	Homo sapiens	94-99
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	15-21	ubiquitin conjugating enzyme E2 N	Homo sapiens	104-109
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	62-68	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	54-58
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	62-68	TNF receptor associated factor 6	Homo sapiens	94-99
19843958-4	2009	Site-specific, lysine 63-linked polyubiquitination of TAK1 at lysine 209, likely catalyzed by TRAF6 and Ubc13, was required for the formation of this complex.	Lysine	62-68	ubiquitin conjugating enzyme E2 N	Homo sapiens	104-109
19829382-6	2009	In contrast, mice with point mutations in the conserved lysine residue of the potential ATP-binding site of the kinase domain, which mediates Ilk binding to alpha-parvin, die owing to renal agenesis.	Lysine	56-62	integrin linked kinase	Mus musculus	142-145
19826488-5	2009	hARD1, which is known to have the activity of protein lysine epsilon-acetylation, bound to and acetylated MLCK activated by Ca(2+) signaling, and by so doing deactivated MLCK, which led to a reduction in the phosphorylation of MLC.	Lysine	54-60	myosin light chain kinase	Homo sapiens	106-110
19826488-5	2009	hARD1, which is known to have the activity of protein lysine epsilon-acetylation, bound to and acetylated MLCK activated by Ca(2+) signaling, and by so doing deactivated MLCK, which led to a reduction in the phosphorylation of MLC.	Lysine	54-60	myosin light chain kinase	Homo sapiens	170-174
19825182-2	2009	This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH).	Lysine	123-129	deoxyhypusine hydroxylase	Homo sapiens	178-203
19825182-2	2009	This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH).	Lysine	123-129	deoxyhypusine hydroxylase	Homo sapiens	205-209
19661062-6	2009	By contrast, mutation of Lys(114) solely affected the preferential interaction of the pentasaccharide with activated antithrombin.	Lysine	25-28	serpin family C member 1	Homo sapiens	117-129
19661062-7	2009	These findings demonstrate that the 3-O-sulfo group functions as a key determinant of heparin pentasaccharide activation of antithrombin both by contributing to the Lys(114)-independent recognition of native antithrombin and by triggering a Lys(114)-dependent induced fit interaction with activated antithrombin that locks the serpin in the activated state.	Lysine	165-168	serpin family C member 1	Homo sapiens	124-136
19661062-7	2009	These findings demonstrate that the 3-O-sulfo group functions as a key determinant of heparin pentasaccharide activation of antithrombin both by contributing to the Lys(114)-independent recognition of native antithrombin and by triggering a Lys(114)-dependent induced fit interaction with activated antithrombin that locks the serpin in the activated state.	Lysine	241-244	serpin family C member 1	Homo sapiens	124-136
19809202-7	2009	We found that Gap1 was removed from the plasma membrane in the presence of ethanol in a Rsp5-dependent manner, and that the disappearance of Gap1 required Ubc4 and involved the lysine residues of ubiquitin.	Lysine	177-183	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	88-92
19809202-10	2009	In addition, it appears that the substrates of Rsp5 are appropriately poly-ubiquitinated via different lysine residues of ubiquitin under various growth conditions.	Lysine	103-109	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	47-51
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	66-69	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	19-23
19789334-3	2009	Here, we show that ASK1-dependent phosphorylation of Daxx induces Lys(63) (K63)-linked polyubiquitination on Lys(122) of Daxx.	Lysine	109-112	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	19-23
19577564-4	2009	FOXP3 proteins in Tregs are present in a dynamic protein complex containing histone acetyltransferase and HDAC enzymes, and FOXP3 itself is acetylated on lysine residues.	Lysine	154-160	forkhead box P3	Mus musculus	0-5
9370364-5	1997	Typically, in cells transiently activated by fMet-Leu-Phe-Lys, onset of superoxide production coincides with the appearance of new phosphorylated species of p40phox and, at the end of the respiratory burst, dephosphorylation of p40phox is observed.	Lysine	58-61	neutrophil cytosolic factor 4	Homo sapiens	157-164
9370364-5	1997	Typically, in cells transiently activated by fMet-Leu-Phe-Lys, onset of superoxide production coincides with the appearance of new phosphorylated species of p40phox and, at the end of the respiratory burst, dephosphorylation of p40phox is observed.	Lysine	58-61	neutrophil cytosolic factor 4	Homo sapiens	228-235
9307942-3	1997	The Schiff bases of the amino acids and myoglobin were obtained by reacting the aldehyde with an excess of isoleucine, valine, lysine, methyl ester lysine and myoglobin in aqueous methanol for 18 h at room temperature.	Lysine	127-133	myoglobin	Homo sapiens	40-49
9307942-3	1997	The Schiff bases of the amino acids and myoglobin were obtained by reacting the aldehyde with an excess of isoleucine, valine, lysine, methyl ester lysine and myoglobin in aqueous methanol for 18 h at room temperature.	Lysine	148-154	myoglobin	Homo sapiens	40-49
9338968-5	1997	Expression of a series of truncated CND41 proteins in Escherichia coli indicated that the lysine-rich region is essential for DNA binding and that CND41 nonspecifically binds chloroplast DNA.	Lysine	90-96	aspartyl protease family protein At5g10770-like	Nicotiana tabacum	36-41
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	38-44	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	97-100	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9252357-8	1997	Based on the analysis of 67 transglutaminase substrate repeats as present in all known Trappin gene family members from four different mammalian species a consensus sequence could be established: Gly-Gln-Asp-Pro-Val-Lys (GQDPVK).	Lysine	216-219	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	28-44
9279329-7	1997	Initially, this high incidence was attributed to infection via consumption of sheep brains or eyeballs, but a mutation at codon 200 in PRNP resulting in the substitution of lysine (K) for glutamate (E), designated E200K, was identified in this population.	Lysine	173-179	major prion protein	Ovis aries	135-139
9188485-2	1997	Deoxyhypusine synthase catalyzes the formation of deoxyhypusine by conjugation of the butylamine moiety of spermidine to the epsilon-amino group of one specific lysine residue of the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein.	Lysine	161-167	eukaryotic translation initiation factor 5A	Homo sapiens	183-226
9188485-2	1997	Deoxyhypusine synthase catalyzes the formation of deoxyhypusine by conjugation of the butylamine moiety of spermidine to the epsilon-amino group of one specific lysine residue of the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein.	Lysine	161-167	eukaryotic translation initiation factor 5A	Homo sapiens	228-234
9467753-1	1997	Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin.	Lysine	91-94	Sp5 transcription factor	Homo sapiens	14-18
9152842-3	1997	The base change results in the replacement of a lysine by glutamic acid in Ig-like loop III of FGFR2.	Lysine	48-54	fibroblast growth factor receptor 2	Homo sapiens	95-100
9042912-7	1997	On the other hand, when lysine was substituted for R-264 (R264K), the mutant alpha1 subunit was able to form dimers that retain significant MAT activity, suggesting that amino acid 264 is involved in intersubunit salt-bridge formation.	Lysine	24-30	adrenoceptor alpha 1D	Homo sapiens	77-83
9056190-2	1997	This substrate consists of modified lysine (N-alpha-[3H]acetyl-l-lysine-N-methylamide or ALMA), linked by its epsilon-amino group to a gamma-carboxyl amide group of casein with guinea pig liver transglutaminase or Factor XIIIa.	Lysine	36-42	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	194-210
9013608-4	1997	Efficient and productive adsorption of the Class I bovine pancreatic phospholipase A2 to anionic interfaces is dependent upon the presence of two nonconserved lysine residues at sequence positions 56 and 116, implying that critical components of the adsorption surface differ among enzyme species (Dua, R., Wu, S.-K., and Cho, W. (1995) J. Biol.	Lysine	159-165	LOC104974671	Bos taurus	69-85
9013608-9	1997	Lysine residues at sequence positions 7 and 10 mediate the adsorption of A. p. piscivorus phospholipase A2 to anionic interfaces but play little role in the enzyme"s interaction with electrically neutral surfaces or in substrate binding.	Lysine	0-6	LOC104974671	Bos taurus	90-106
9013608-11	1997	The calculated contributions of Lys-7 and Lys-10 to the free energy of binding of A. p. piscivorus phospholipase A2 to anionic liposomes (-1.8 kcal/mol at 25 degrees C per lysine) are additive (i.e. -3.7 kcal/mol) and together represent nearly half of the total binding energy.	Lysine	172-178	LOC104974671	Bos taurus	99-115
9033386-1	1997	Rat serum mannose-binding protein in which residues 211-213 have been changed to the Lys-Lys-Lys sequence found in E-selectin binds HL-60 cells and the oligosaccharide 3"-NeuAc-Le(x).	Lysine	85-88	selectin E	Homo sapiens	115-125
9033386-1	1997	Rat serum mannose-binding protein in which residues 211-213 have been changed to the Lys-Lys-Lys sequence found in E-selectin binds HL-60 cells and the oligosaccharide 3"-NeuAc-Le(x).	Lysine	89-92	selectin E	Homo sapiens	115-125
9033386-1	1997	Rat serum mannose-binding protein in which residues 211-213 have been changed to the Lys-Lys-Lys sequence found in E-selectin binds HL-60 cells and the oligosaccharide 3"-NeuAc-Le(x).	Lysine	89-92	selectin E	Homo sapiens	115-125
8993325-0	1997	A lysine 73--&gt;histidine variant of yeast iso-1-cytochrome c: evidence for a native-like intermediate in the unfolding pathway and implications for m value effects.	Lysine	2-8	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	44-49
8993325-1	1997	In this paper we report thermodynamic studies on a variant of yeast iso-1-cytochrome c in which a surface lysine residue at position 73 has been replaced with a histidine (H73).	Lysine	106-112	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	68-73
9003434-6	1997	Removal of the C-terminal lysine residue of r-alpha-enolase with carboxy-peptidase B significantly reduced its plasminogen binding capacity, suggesting that binding required C-terminal lysine residue of r-alpha-enolase.	Lysine	26-32	enolase 1	Homo sapiens	46-59
9003434-6	1997	Removal of the C-terminal lysine residue of r-alpha-enolase with carboxy-peptidase B significantly reduced its plasminogen binding capacity, suggesting that binding required C-terminal lysine residue of r-alpha-enolase.	Lysine	26-32	enolase 1	Homo sapiens	205-218
9003434-6	1997	Removal of the C-terminal lysine residue of r-alpha-enolase with carboxy-peptidase B significantly reduced its plasminogen binding capacity, suggesting that binding required C-terminal lysine residue of r-alpha-enolase.	Lysine	185-191	enolase 1	Homo sapiens	46-59
9357050-1	1997	The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor.	Lysine	77-80	prepronociceptin	Rattus norvegicus	37-47
9357050-1	1997	The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor.	Lysine	93-96	prepronociceptin	Rattus norvegicus	37-47
8931557-13	1996	(b) The efficiency of electron transfer to cytochrome f from the Rieske protein is slightly impaired by the neutralization of the lysine-rich domain.	Lysine	130-136	cytochrome f	Chlamydomonas reinhardtii	43-55
8931561-3	1996	Peptide mapping of the reaction products by mass spectrometry showed that, with low DEP:M-CSF ratios (&lt; 50:1), there was selective modification of histidine residues, whereas at higher ratios (&gt; 50:1), Tyr and Lys residues were also modified.	Lysine	216-219	colony stimulating factor 1	Homo sapiens	88-93
8910598-0	1996	Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin.	Lysine	25-31	serpin family C member 1	Homo sapiens	76-88
8914020-3	1996	We hypothesize that uremic toxins form Schiff bases with the lysine residues of the VDR DNA binding domain and inhibit the VDR interaction with the VDRE.	Lysine	61-67	vitamin D receptor	Rattus norvegicus	84-87
12239373-4	1996	These data suggest that EF-1[alpha] and actin are associated in maize endosperm cells and may help to explain the basis of the correlation we found between the concentration of EF-1[alpha] and lysine content.	Lysine	193-199	elongation factor 1-alpha	Zea mays	24-34
12239373-4	1996	These data suggest that EF-1[alpha] and actin are associated in maize endosperm cells and may help to explain the basis of the correlation we found between the concentration of EF-1[alpha] and lysine content.	Lysine	193-199	actin-7	Zea mays	40-45
12239373-4	1996	These data suggest that EF-1[alpha] and actin are associated in maize endosperm cells and may help to explain the basis of the correlation we found between the concentration of EF-1[alpha] and lysine content.	Lysine	193-199	elongation factor 1-alpha	Zea mays	177-187
8871678-3	1996	Based on a three-dimensional model of beta2GPI, electrostatic calculations, and earlier peptide studies, a highly positively charged amino acid sequence, Lys282-Asn-Lys-Glu-Lys-Lys287, located in the fifth domain of beta2GPI, has been predicted to be the phospholipid binding site.	Lysine	154-157	apolipoprotein H	Homo sapiens	38-46
8871678-3	1996	Based on a three-dimensional model of beta2GPI, electrostatic calculations, and earlier peptide studies, a highly positively charged amino acid sequence, Lys282-Asn-Lys-Glu-Lys-Lys287, located in the fifth domain of beta2GPI, has been predicted to be the phospholipid binding site.	Lysine	154-157	apolipoprotein H	Homo sapiens	216-224
8871678-3	1996	Based on a three-dimensional model of beta2GPI, electrostatic calculations, and earlier peptide studies, a highly positively charged amino acid sequence, Lys282-Asn-Lys-Glu-Lys-Lys287, located in the fifth domain of beta2GPI, has been predicted to be the phospholipid binding site.	Lysine	165-168	apolipoprotein H	Homo sapiens	38-46
8871678-3	1996	Based on a three-dimensional model of beta2GPI, electrostatic calculations, and earlier peptide studies, a highly positively charged amino acid sequence, Lys282-Asn-Lys-Glu-Lys-Lys287, located in the fifth domain of beta2GPI, has been predicted to be the phospholipid binding site.	Lysine	165-168	apolipoprotein H	Homo sapiens	216-224
8896442-6	1996	Arrangement of this Glu226 carboxylate would also allow accommodation of a Lys side chain in this S1 pocket, in agreement with the recently observed cathepsin G preference for Lys and Phe at P1.	Lysine	75-78	cathepsin G	Homo sapiens	149-160
8896442-6	1996	Arrangement of this Glu226 carboxylate would also allow accommodation of a Lys side chain in this S1 pocket, in agreement with the recently observed cathepsin G preference for Lys and Phe at P1.	Lysine	176-179	cathepsin G	Homo sapiens	149-160
8964456-5	1996	Molecular modelling of TEM-2, when compared to that of TEM-1, showed an additional ionic bond between Lys-39 and Glu-281.	Lysine	102-105	CD248 molecule	Homo sapiens	55-60
8774851-7	1996	Unlike rat cathepsin B, which cleaves peptide PB8 at the G47p-G48p bond after prolonged incubation, the human enzyme cleaved both PB8 and PB11 at the Lys-40p-Leu-41p bond, in agreement with the different kinetic properties of these two proteinases.	Lysine	150-153	cathepsin B	Rattus norvegicus	11-22
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Lysine	94-97	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Lysine	122-125	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8690792-0	1996	Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes.	Lysine	69-75	aminopeptidase O (putative)	Homo sapiens	47-50
8690792-0	1996	Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes.	Lysine	145-151	aminopeptidase O (putative)	Homo sapiens	47-50
8690792-1	1996	It is now established that the lysine binding site (LBS) of apo(a) kringle IV-10, and particularly Trp72, plays a dominant role in the binding of lipoprotein(a) [Lp(a)] to lysine.	Lysine	31-37	aminopeptidase O (putative)	Homo sapiens	60-63
8690792-1	1996	It is now established that the lysine binding site (LBS) of apo(a) kringle IV-10, and particularly Trp72, plays a dominant role in the binding of lipoprotein(a) [Lp(a)] to lysine.	Lysine	172-178	aminopeptidase O (putative)	Homo sapiens	60-63
8690792-5	1996	We conclude that the LBS of kringle IV-10 is not involved in this process and that apo(a) binds to PM-fibrinogen via a lysine-proline-sensitive domain located outside the LBS and largely masked by the interaction of apo(a) with apoB100.	Lysine	119-125	aminopeptidase O (putative)	Homo sapiens	83-86
8662867-7	1996	By mutagenesis, we showed that two differences (methionine instead of tyrosine at position 70; lysine instead of aspartate or glutamate at position 285) explain the low sensitivity of Bungarus AChE to peripheral site inhibitors, compared to the Torpedo or mammalian AChEs.	Lysine	95-101	acetylcholinesterase	Rattus norvegicus	193-197
8811737-0	1996	Chemical cross-linking between lysine groups in vimentin oligomers is dependent on local peptide conformations.	Lysine	31-37	vimentin	Homo sapiens	48-56
8811737-3	1996	In the present study, molecular modeling of the conformations of vimentin molecules indicated that lysine side chains in identical positions in regions of alpha-helix in parallel chains might be unable to be linked because they are on opposite sides of the coiled coil hydrophobic core.	Lysine	99-105	vimentin	Homo sapiens	65-73
8662686-2	1996	Competition experiments with methylamine-treated alpha2-macroglobulin for binding to the multifunctional alpha2-macroglobulin receptor identify two Lys residues (residues 1370 and 1374 in human alpha2-macroglobulin) spaced by three amino acid residues as crucial for receptor binding.	Lysine	148-151	alpha-2-macroglobulin	Homo sapiens	49-69
8662686-2	1996	Competition experiments with methylamine-treated alpha2-macroglobulin for binding to the multifunctional alpha2-macroglobulin receptor identify two Lys residues (residues 1370 and 1374 in human alpha2-macroglobulin) spaced by three amino acid residues as crucial for receptor binding.	Lysine	148-151	alpha-2-macroglobulin	Homo sapiens	105-125
8638161-3	1996	In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail.	Lysine	187-190	synaptophysin	Mus musculus	74-77
8638161-3	1996	In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail.	Lysine	187-190	synaptophysin	Mus musculus	142-145
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	155-158
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	163-166
8662595-4	1996	The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.	Lysine	101-104	LIF interleukin 6 family cytokine	Homo sapiens	20-24
8626701-4	1996	Mutations of Arg-124, Ser-126, Lys-128, and Gln-129 inhibited both phosphorylation and TCR down-regulation, whereas mutation of Asp-127 only inhibited down-regulation.	Lysine	31-34	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	87-90
8615810-1	1996	Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor by transferring an aminobutyl moiety from spermidine to the epsilon-amino group of a unique lysine residue.	Lysine	259-265	eukaryotic translation initiation factor 5A	Homo sapiens	116-147
8615810-1	1996	Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor by transferring an aminobutyl moiety from spermidine to the epsilon-amino group of a unique lysine residue.	Lysine	259-265	eukaryotic translation initiation factor 5A	Homo sapiens	149-155
8934924-9	1996	Many of the RF-reactive sites on C gamma 2 and C gamma 3 as well as on beta 2m show common immunodominant valines, leucines, tryptophanes, arginines, lysines, and glutamines, thus comprising common reactive residues.	Lysine	150-157	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	33-56
8934924-9	1996	Many of the RF-reactive sites on C gamma 2 and C gamma 3 as well as on beta 2m show common immunodominant valines, leucines, tryptophanes, arginines, lysines, and glutamines, thus comprising common reactive residues.	Lysine	150-157	beta-2-microglobulin	Homo sapiens	71-78
8852756-0	1996	Probing structure-activity relationship in diamine oxidase--reactivities of lysine and arginine residues.	Lysine	76-82	amine oxidase copper containing 1	Sus scrofa	43-58
8852756-1	1996	Lysine and arginine residues of pig kidney diamine oxidase (DAO) were modified with 2,4,6-trinitrobenzenesulphonic acid (TNBS), 2,3-butanedione and phenylglyoxal, respectively, using different concentrations and time periods.	Lysine	0-6	amine oxidase copper containing 1	Sus scrofa	43-58
8852756-1	1996	Lysine and arginine residues of pig kidney diamine oxidase (DAO) were modified with 2,4,6-trinitrobenzenesulphonic acid (TNBS), 2,3-butanedione and phenylglyoxal, respectively, using different concentrations and time periods.	Lysine	0-6	amine oxidase copper containing 1	Sus scrofa	60-63
8573586-16	1996	Further, by introducing a positive charge to alpha-helix II (alpha-II) of the helical cap region, 2AP transfer rates increased by 4-fold and properties of HFABP transfer began to approach those seen for AFABP, another member of the FABP family thought to transfer ligand via collisional interactions with membranes, which has a lysine residue in the alpha-II helix.	Lysine	328-334	fatty acid binding protein 4	Homo sapiens	203-208
9116050-5	1996	Using spectral titration at 325 nm, the stoichiometry was 2 mol/mol of GDH subunit without protection and 1 mol/mol with protection, indicating the complete masking of one mol of lysine.	Lysine	179-185	glutamate dehydrogenase 1	Homo sapiens	71-74
8785711-3	1996	Recombinant human EGF was chemically modified to allow for its attachment to DNA through the use of the poly-cation poly-L-lysine (PLL).	Lysine	116-129	epidermal growth factor	Homo sapiens	18-21
8839354-4	1996	Time-dependent increase of aromatase mRNA was also observed for 3 days in E13 neuronal cells dissociated with papain and cultured on poly L-Lys-coated dishes in serum-free medium.	Lysine	140-143	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	27-36
8839354-4	1996	Time-dependent increase of aromatase mRNA was also observed for 3 days in E13 neuronal cells dissociated with papain and cultured on poly L-Lys-coated dishes in serum-free medium.	Lysine	140-143	skull morphology 19	Mus musculus	74-77
8554326-8	1995	In the cross-linked peptide, Lys-242 of the receptor cross-linked the amino terminal Met of G-CSF through the cross-linker.	Lysine	29-32	colony stimulating factor 3	Homo sapiens	92-97
8554326-10	1995	The results show that the N-terminal Met of G-CSF is located at a distance of approximately 11 A from a reactive Lys-242 of the receptor in the ligand-receptor complex.	Lysine	113-116	colony stimulating factor 3	Homo sapiens	44-49
8530405-5	1995	The most interesting observation was noted with two point mutants of LH/CG-R, Glu332--&gt;Lys and Asp333--&gt;Lys, which bound hCG but failed to give increased cAMP production.	Lysine	90-93	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	69-76
8530405-5	1995	The most interesting observation was noted with two point mutants of LH/CG-R, Glu332--&gt;Lys and Asp333--&gt;Lys, which bound hCG but failed to give increased cAMP production.	Lysine	110-113	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	69-76
8530405-9	1995	The Lys235--&gt;Asp and Asp333--&gt;Lys mutants exhibited primarily the lower M(r) form, indicating that receptor processing was impaired or that the mutant higher M(r) form was more rapidly degraded than LH/CG-R wild type.	Lysine	4-7	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	205-212
8600990-1	1995	The review summarizes contemporary views on the biological role, levels and mechanisms of regulation of carboxypeptidase H--the exopeptidase of secretory vesicles removing arginine and lysine residues from C-termini of peptides.	Lysine	185-191	carboxypeptidase E	Homo sapiens	104-122
8614409-2	1995	We examined the analogous region in the rat follitropin receptor (rFSHR) by substituting the Asp at position 404 (D404) of the rFSHR with either Glu (D404E), Ala (D404A), or Lys (D404K).	Lysine	174-177	follicle stimulating hormone receptor	Rattus norvegicus	66-71
7592870-5	1995	Among these, three lysine residues, at positions 327, 328, and 332 in the middle of the C2B domain, which is not conserved in the C2A domain, were found to be essential for IP4 binding in synaptotagmin II.	Lysine	19-25	synaptotagmin 2	Homo sapiens	188-204
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	196-199	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	196-199	sucrase-isomaltase	Homo sapiens	239-257
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	200-203	sucrase-isomaltase	Homo sapiens	79-97
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Lysine	200-203	sucrase-isomaltase	Homo sapiens	239-257
7478569-4	1995	However, a mutation in Mos that removed two basic amino acid residues (R94 and K97) downstream from the lysine at the ATP binding site (K90) markedly enhanced autophosphorylation activity.	Lysine	104-110	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	23-26
7559487-6	1995	Replacing the phosphorylation sites with alanine residues had a similar effect, while substitution with aspartate, glutamate, or lysine residues produced pleckstrin variants that were fully active even in the absence of phosphorylation.	Lysine	129-135	pleckstrin	Homo sapiens	154-164
7588773-5	1995	The binding activity of prothymosin alpha to Rev or Rex was completely abolished when the epsilon-amino groups of its lysine residues were chemically modified by N-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate.	Lysine	118-124	prothymosin alpha pseudogene 9	Homo sapiens	24-41
7588773-5	1995	The binding activity of prothymosin alpha to Rev or Rex was completely abolished when the epsilon-amino groups of its lysine residues were chemically modified by N-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate.	Lysine	118-124	p27	Human T-cell leukemia virus type I	52-55
7561862-2	1995	The most suitable residues for glycation, lysines, present at the tubulin-binding motif of tau protein, seem to be preferentially modified compared with those lysines present at other regions.	Lysine	42-49	microtubule associated protein tau	Homo sapiens	91-94
7561862-2	1995	The most suitable residues for glycation, lysines, present at the tubulin-binding motif of tau protein, seem to be preferentially modified compared with those lysines present at other regions.	Lysine	159-166	microtubule associated protein tau	Homo sapiens	91-94
7561862-3	1995	Among these modified lysines, those located in the sequence comprising residues 318-336 (in the largest human tau isoform) were found to be glycated, as determined by the reaction with an antibody that recognizes a glycated peptide containing this sequence.	Lysine	21-28	microtubule associated protein tau	Homo sapiens	110-113
7561862-4	1995	Because those lysines are present in a tubulin binding motif of tau protein, its modification could result in a decrease in the interaction of tau with tubulin.	Lysine	14-21	microtubule associated protein tau	Homo sapiens	64-67
7561862-4	1995	Because those lysines are present in a tubulin binding motif of tau protein, its modification could result in a decrease in the interaction of tau with tubulin.	Lysine	14-21	microtubule associated protein tau	Homo sapiens	143-146
19577564-4	2009	FOXP3 proteins in Tregs are present in a dynamic protein complex containing histone acetyltransferase and HDAC enzymes, and FOXP3 itself is acetylated on lysine residues.	Lysine	154-160	forkhead box P3	Mus musculus	124-129
19707690-2	2009	Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group.	Lysine	120-123	CD24 molecule	Rattus norvegicus	96-100
19748360-3	2009	Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for activation of the E2 approximately SUMO thioester, while the PINIT domain is essential for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a nonconsensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1.	Lysine	282-288	proliferating cell nuclear antigen	Homo sapiens	237-271
19748360-3	2009	Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for activation of the E2 approximately SUMO thioester, while the PINIT domain is essential for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a nonconsensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1.	Lysine	309-315	proliferating cell nuclear antigen	Homo sapiens	237-271
19051060-5	2009	Variant genotypes XRCC1 Arg/Gln or Gln/Gln and XPD Lys/Gln or Gln/Gln increased both familial and sporadic breast cancer susceptibility.	Lysine	51-54	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	47-50
19750210-2	2009	Trimethylation of histone 3 lysine 9 (H3K9me3) leads to chromatin silencing and the formation of heterochromatin by recruitment of heterochromatin protein 1 (HP1).	Lysine	28-34	chromobox 5	Homo sapiens	131-156
19750210-2	2009	Trimethylation of histone 3 lysine 9 (H3K9me3) leads to chromatin silencing and the formation of heterochromatin by recruitment of heterochromatin protein 1 (HP1).	Lysine	28-34	chromobox 5	Homo sapiens	158-161
19621874-1	2009	(G:3-7)-dendri-PAMAM-(APO-Phe-Lys)(x) (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5"-phosphate.	Lysine	30-33	aminopeptidase O (putative)	Homo sapiens	22-25
19621874-1	2009	(G:3-7)-dendri-PAMAM-(APO-Phe-Lys)(x) (2, APO = aminopropanol, Phe = phenylalanine, Lys = lysine) were prepared and used in a binding study with pyridoxal 5"-phosphate.	Lysine	30-33	aminopeptidase O (putative)	Homo sapiens	42-45
7548152-4	1995	In the ferric state, the protein modified at lysine 72 remained stable as a monomer, but that modified at lysine 73 dimerized rapidly through disulfide bond formation, while the TP Lys-79 cytochrome c dimerized with a half-time of approx.	Lysine	181-184	cytochrome c, somatic	Equus caballus	188-200
32185890-1	2020	HLA-DRB3*03:39 differs from HLA-DRB3*03:01:01 by a single nucleotide substitution in codon 22 (Glutamic acid to Lysine).	Lysine	112-118	major histocompatibility complex, class II, DR beta 3	Homo sapiens	28-36
19621874-3	2009	(G:3-7)-dendri-PAMAM-(APO-Phe-Lys)(x) (2) demonstrated better binding ability at higher pH, and protonation of lysine was considered to affect binding.	Lysine	111-117	aminopeptidase O (putative)	Homo sapiens	22-25
32681621-8	2020	Similarly, PLOD3 gene shows missense mutation in heterozygous condition due to loss of guanine in the sequence AGG A-G and it is responsible for the change in post-translational event of amino acid where arginine change into lysine.	Lysine	225-231	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	11-16
19666599-4	2009	Through electron and immunofluorescence microscopy studies, we show that BAHD1 overexpression directs HP1 to specific nuclear sites and promotes the formation of large heterochromatic domains, which lack acetyl histone H4 and are enriched in H3 trimethylated at lysine 27 (H3K27me3).	Lysine	262-268	bromo adjacent homology domain containing 1	Homo sapiens	73-78
7547918-6	1995	Recombinant A-FABP was acetylated to neutralize all positively charged surface lysine residues.	Lysine	79-85	fatty acid binding protein 4	Homo sapiens	12-18
7662862-1	1995	Photoaffinity labeling with bovine rhodopsin using a retinal with a fixed 11-cis-ene cross-linked exclusively to Trp-265/Leu-266 in helix F, showing that the beta-ionone C-3 is close to helix F. Moreover, since these labeled amino acids are in the middle of helix F, while the Schiff-base linkage to Lys-296 at the other terminus of the chromophore is also in the middle of helix G, the chromophore lies horizontally near the center of the lipid bilayer.	Lysine	300-303	rhodopsin	Bos taurus	35-44
7642593-2	1995	Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1.	Lysine	66-69	proprotein convertase subtilisin/kexin type 1	Homo sapiens	185-188
32579914-5	2020	The expression of NeuroD1 in bulk MB cells is repressed by trimethylation of histone 3 lysine-27 (H3K27me3).	Lysine	87-93	neuronal differentiation 1	Homo sapiens	18-25
7633739-1	1995	Carboxypeptidase M (CPM) cleaves the C-terminal arginine and lysine of peptides; it is expressed in the lung, especially on the plasma membrane of alveolar type I cells.	Lysine	61-67	carboxypeptidase M	Homo sapiens	0-18
7633739-1	1995	Carboxypeptidase M (CPM) cleaves the C-terminal arginine and lysine of peptides; it is expressed in the lung, especially on the plasma membrane of alveolar type I cells.	Lysine	61-67	carboxypeptidase M	Homo sapiens	20-23
32695416-0	2020	Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.	Lysine	110-116	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	51-57
7661866-2	1995	Three schemes of synthesis for pentapeptide Glp-Glu-Asp-Cys-Lys-OH were compared was carried out.	Lysine	60-63	euchromatic histone lysine methyltransferase 1	Homo sapiens	44-47
19684477-4	2009	SET7/9 plays a prominent role in lysine methylation of histone and non-histone proteins.	Lysine	33-39	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	Lysine	148-154	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	126-132
19615999-2	2009	Whereas the former share common sequence motives in their viral capsid proteins (VPs), in the latter only a lysine residue within the binding epitope in VP1 is conserved; this lysine is also present in "K-type" major group HRVs that fail to use LDLR for infection.	Lysine	176-182	low density lipoprotein receptor	Homo sapiens	245-249
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	47-53
7610159-6	1995	We conclude that in the presence of Ca(2+)-hydrophobic interactions involving tryptophan-485 and electrostatic interactions involving the carboxy-terminal lysines mediate CaM/GAD complex formation.	Lysine	155-162	glutamate decarboxylase	Arabidopsis thaliana	175-178
7610159-7	1995	By contrast, in the absence of Ca2+, CaM/GAD interactions are essentially electrostatic and involve the carboxy-terminal lysines.	Lysine	121-128	glutamate decarboxylase	Arabidopsis thaliana	41-44
7610159-8	1995	In addition, a tryptophan residue and carboxy-terminal lysines are present in the CaM-binding domain of an Arabidopsis GAD.	Lysine	55-62	glutamate decarboxylase	Arabidopsis thaliana	119-122
19546378-5	2009	Sequencing of fumarase cDNA indicated the presence of lysine at amino acid position 481 in Dahl salt-sensitive rats and glutamic acid in Brown Norway and SS-13(BN) rats.	Lysine	54-60	fumarate hydratase	Rattus norvegicus	14-22
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	55-118
7672445-8	1995	Since this aminopeptidase-B was able in vitro to trim out N-terminal Arg and/or Lys residues from peptides mimicking processing intermediates, it is proposed that this enzyme may be involved in propeptide and proprotein processing mechanisms in the course of spermatid differentiation.	Lysine	80-83	arginyl aminopeptidase	Rattus norvegicus	11-27
32399807-1	2020	Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFkappaB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.	Lysine	49-52	telomerase reverse transcriptase	Homo sapiens	118-122
19691749-7	2009	Gene analysis revealed an E478K (Glu to Lys) mutation in exon 5 of the keratin 5 (K5) gene.	Lysine	40-43	keratin 5	Homo sapiens	71-80
19691749-7	2009	Gene analysis revealed an E478K (Glu to Lys) mutation in exon 5 of the keratin 5 (K5) gene.	Lysine	40-43	keratin 5	Homo sapiens	82-84
32460017-5	2020	Upon DC activation, JNK signaling stimulated p300 association with PKM2 for the acetylation of lysine 433, a classic posttranslational modification critical for PKM2 destabilization and nuclear re-localization.	Lysine	95-101	pyruvate kinase M1/2	Homo sapiens	67-71
19643030-7	2009	Besides, acetylation at Lysine 8 and 12 of HISTONE H4 in soybean were identified.	Lysine	24-30	histone H4	Glycine max	43-53
19643030-11	2009	Lysine 4 and Lysine 36 methylation were only detected in HISTONE H3.2, suggesting that HISTONE variant H3.2 might be associated with actively transcribing genes.	Lysine	0-6	histone H3.2	Glycine max	57-69
7724596-1	1995	The missense mutation Lys-296--&gt;Glu (K296E) in the rhodopsin gene produces an opsin with no chromophore binding site and therefore is not activated by light.	Lysine	22-25	rhodopsin	Mus musculus	54-63
32460017-5	2020	Upon DC activation, JNK signaling stimulated p300 association with PKM2 for the acetylation of lysine 433, a classic posttranslational modification critical for PKM2 destabilization and nuclear re-localization.	Lysine	95-101	pyruvate kinase M1/2	Homo sapiens	161-165
7543205-0	1995	Introduction of lysine residues on the light chain constant domain improves the labelling properties of a recombinant Fab fragment.	Lysine	16-22	FA complementation group B	Homo sapiens	118-121
7543205-3	1995	Here the labelling efficiency of a recombinant anti-human alpha-fetoprotein (hAFP) Fab fragment has been improved by increasing its lysine content by protein engineering.	Lysine	132-138	FA complementation group B	Homo sapiens	83-86
19643030-11	2009	Lysine 4 and Lysine 36 methylation were only detected in HISTONE H3.2, suggesting that HISTONE variant H3.2 might be associated with actively transcribing genes.	Lysine	13-19	histone H3.2	Glycine max	57-69
32466590-1	2020	The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells.	Lysine	39-45	ubiquitin specific peptidase 16	Homo sapiens	73-78
19433580-0	2009	Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains.	Lysine	86-92	Jen1p	Saccharomyces cerevisiae S288C	60-64
19433580-7	2009	Jen1 is modified at the cell surface by oligo-ubiquitylation with ubiquitin-Lys(63) linked chain(s), and Jen1-Lys(338) is one of the target residues.	Lysine	76-79	Jen1p	Saccharomyces cerevisiae S288C	0-4
19433580-7	2009	Jen1 is modified at the cell surface by oligo-ubiquitylation with ubiquitin-Lys(63) linked chain(s), and Jen1-Lys(338) is one of the target residues.	Lysine	110-113	Jen1p	Saccharomyces cerevisiae S288C	0-4
19433580-7	2009	Jen1 is modified at the cell surface by oligo-ubiquitylation with ubiquitin-Lys(63) linked chain(s), and Jen1-Lys(338) is one of the target residues.	Lysine	110-113	Jen1p	Saccharomyces cerevisiae S288C	105-109
19433580-8	2009	Ubiquitin-Lys(63)-linked chain(s) are also required directly or indirectly to sort Jen1 into multivesicular bodies.	Lysine	10-13	Jen1p	Saccharomyces cerevisiae S288C	83-87
19433580-9	2009	Jen1 is one of the few examples for which ubiquitin-Lys(63)-linked chain(s) was shown to be required for correct trafficking at two stages of endocytosis: endocytic internalization and sorting at multivesicular bodies.	Lysine	52-55	Jen1p	Saccharomyces cerevisiae S288C	0-4
19478089-5	2009	Within this surface, the Asn-115 residue of human SHH has been documented to associate with HPE when mutated to lysine (N115K).	Lysine	112-118	sonic hedgehog signaling molecule	Homo sapiens	50-53
19442507-2	2009	A mutant of GBP was labelled with badan near the binding site, the protein adsorbed to microparticles of CaCO(3) as templates and encapsulated in alternating nano-layers of poly-L-lysine and heparin.	Lysine	173-186	transmembrane protein 132A	Homo sapiens	12-15
19263424-5	2009	This work presents a method named MASA that combines the support vector machine with the sequence and structural characteristics of proteins to identify methylation sites on lysine, arginine, glutamate, and asparagine.	Lysine	174-180	enolase-phosphatase 1	Homo sapiens	34-38
19432880-4	2009	In addition, the Mdmx mutant cooperates with Mdm2 to induce ubiquitination of p53 at C-terminal lysine residues, and the integrity of the C-terminal lysines was partly required for the cooperative inhibition.	Lysine	149-156	MDM4 regulator of p53	Homo sapiens	17-21
19432884-2	2009	We analyzed the influence of codon 751 Lys--&gt;Gln polymorphism of XPD on its protein expression levels, clinico-pathological features, and outcome of 188 Chinese patients with metastatic colorectal carcinoma (CRC) that had been treated with first-line Oxaliplatin + Leucovorin + 5-Fluorouracil (FOLFOX-4) chemotherapy.	Lysine	39-42	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	68-71
19432884-8	2009	These data suggest that Asian populations have a significantly lower prevalence of codon 751 Lys/Gln polymorphism in XPD, which could be a key determinant for good response to oxaliplatin-based treatment and favorable outcomes.	Lysine	93-96	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	117-120
19424988-10	2009	RESULTS: Synthetic peptides with additional lysine residues were well phosphorylated by IKKbeta.	Lysine	44-50	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	88-95
19542455-5	2009	Ubiquitin modification of lysine residues K168 and K183, but not K192, in the cytoplasmic domain of CD83 was shown to be necessary for GRAIL-mediated degradation of CD83.	Lysine	26-32	CD83 molecule	Homo sapiens	100-104
19542455-5	2009	Ubiquitin modification of lysine residues K168 and K183, but not K192, in the cytoplasmic domain of CD83 was shown to be necessary for GRAIL-mediated degradation of CD83.	Lysine	26-32	CD83 molecule	Homo sapiens	165-169
19825650-5	2009	Here, we report that decondensation of the major pericentromeric repeats and depletion of the heterochromatic mark histone H3 lysine 9 dimethylation at chromocenters occurs specifically in pol V and drd1 mutants.	Lysine	126-132	SNF2 domain-containing protein / helicase domain-containing protein	Arabidopsis thaliana	199-203
19379712-3	2009	eIF5A also undergoes an acetylation at specific Lys residue(s).	Lysine	48-51	eukaryotic translation initiation factor 5A	Homo sapiens	0-5
19486666-10	2009	A major reason for the weaker association of MCP in the calculations was the noninterfacial residue Lys-40, which in the dimer structure is forced to be buried in the membrane interior.	Lysine	100-103	capping actin protein, gelsolin like	Homo sapiens	45-48
19486666-11	2009	To alleviate the desolvation cost, in MCP and MCP-GpA dimers, Lys-40 gets deprotonated.	Lysine	62-65	capping actin protein, gelsolin like	Homo sapiens	38-41
19593652-7	2009	Molecular modeling of human cyt c shows that the omega loop where the lysine residue is located apparently further away from heme in human cyt c than in yeast iso-1 and horse heart cyt c.	Lysine	70-76	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	159-164
19332560-8	2009	Moreover, these nat4-Delta phenotypes were enhanced in the strain containing K5R K8R K12R replacements in the N-tail of histone H4, suggesting that the lack of N-terminal serine acetylation is synergistic to the lack of acetylation of the H4 N-tail lysines.	Lysine	249-256	N-terminal L-serine N(alpha)-acetyltransferase NatD	Saccharomyces cerevisiae S288C	16-20
19318352-0	2009	Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.	Lysine	0-6	ornithine transcarbamylase	Homo sapiens	43-73
19164286-7	2009	Using this approach, we identified the glutamine and lysine residues involved in tTG-catalyzed intramolecular cross-linking of alpha-syn.	Lysine	53-59	synuclein alpha	Homo sapiens	127-136
19107532-3	2009	Insulin was shown to stimulate milk protein gene expression, casein synthesis and (14)C-lysine uptake in mammary explants from late pregnant cows.	Lysine	88-94	insulin	Bos taurus	0-7
19459942-10	2009	Using site-directed mutagenesis, we demonstrate that the highly-conserved and positively-charged lysine-rich surface region enhances the toxicity of PAF.	Lysine	97-103	PCNA clamp associated factor	Homo sapiens	149-152
19393168-4	2009	Here we show that recombinant Hbo1 can acetylate nucleosomal histone H4 in vitro, with a preference for lysines 5 and 12.	Lysine	104-111	lysine acetyltransferase 7	Homo sapiens	30-34
19267451-2	2009	A novel non-glycerol based cationic lipid which contains both a guanidinium and a lysine residue as the cationic headgroup, i.e. DSGLA, downregulated pERK more efficiently in H460 cells than DOTAP.	Lysine	82-88	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	150-154
19405949-6	2009	We show that PP2A interacts with the cytoplasmic tail of CTLA-4 in two different sites, one on the lysine rich motif, and the other on the tyrosine residue located at position 182 (but not the tyrosine 165 of the YVKM motif).	Lysine	99-105	protein phosphatase 2 phosphatase activator	Homo sapiens	13-17
19405949-6	2009	We show that PP2A interacts with the cytoplasmic tail of CTLA-4 in two different sites, one on the lysine rich motif, and the other on the tyrosine residue located at position 182 (but not the tyrosine 165 of the YVKM motif).	Lysine	99-105	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	57-63
19251700-5	2009	SUMOylation of the three lysine residues is important for the interaction between AhRR and ANKRA2, HDAC4, and HDAC5, which are important corepressors for AhRR.	Lysine	25-31	histone deacetylase 4	Homo sapiens	99-104
19393081-4	2009	RESULTS: In this study we identified ALIX as a POSH ubiquitination substrate in human cells: POSH induces the ubiquitination of ALIX that is modified on several lysine residues in vivo and in vitro.	Lysine	161-167	programmed cell death 6 interacting protein	Homo sapiens	37-41
19393081-4	2009	RESULTS: In this study we identified ALIX as a POSH ubiquitination substrate in human cells: POSH induces the ubiquitination of ALIX that is modified on several lysine residues in vivo and in vitro.	Lysine	161-167	programmed cell death 6 interacting protein	Homo sapiens	128-132
19383174-3	2009	RESULTS: An analog of the SHAL (DvLPBaPPP)2LLDo containing a hexa-arginine peptide was created by adding six D-arginine residues sequentially to a lysine inserted in the SHAL"s linker.	Lysine	147-153	hexosaminidase subunit alpha	Homo sapiens	61-65
19208623-6	2009	In response to DNA damage, Lys-164 of PCNA undergoes ubiquitination by the RAD6-RAD18 complex, and the ubiquitination is considered to facilitate TLS.	Lysine	27-30	proliferating cell nuclear antigen	Homo sapiens	38-42
19208623-12	2009	Furthermore, these structures enable us to speculate how these TLS polymerases interact with Lys-164-monoubiquitinated PCNA.	Lysine	93-96	proliferating cell nuclear antigen	Homo sapiens	119-123
19351759-9	2009	In vitro results showed that MSI-H cell lines due to hypermethylation of MLH1 are preferentially targeted by rapamycin (18.3 versus 4.4 mumol/L; P = 0.0824) and LY-294002 (15.02 versus 10.37 mumol/L; P = 0.0385) when compared with microsatellite-stable cells.	Lysine	161-163	RB binding protein 4, chromatin remodeling factor	Homo sapiens	29-32
19351759-9	2009	In vitro results showed that MSI-H cell lines due to hypermethylation of MLH1 are preferentially targeted by rapamycin (18.3 versus 4.4 mumol/L; P = 0.0824) and LY-294002 (15.02 versus 10.37 mumol/L; P = 0.0385) when compared with microsatellite-stable cells.	Lysine	161-163	mutL homolog 1	Homo sapiens	73-77
19230796-3	2009	A less well-known aspect of Rad6-mediated DNA repair, however, involves its function with Bre1 in mono-ubiquitinating the histone H2B residue lysine 123.	Lysine	142-148	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	28-32
19090718-4	2009	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and N-terminal sequence analyses show that KLK9 and 10 exhibit low hydrolytic activities towards all of the 15 pro-KLK sequences, while KLK15 exhibits significant activity towards both Arg- and Lys-containing KLK pro-sequences.	Lysine	272-275	kallikrein related peptidase 9	Homo sapiens	121-125
19307613-8	2009	The increased rate of hydrolysis by plasmin toward the cleavage site Lys(68)-Ser(69) has to be ascribed to the elevated proline content of the peptide 61-73.	Lysine	69-72	plasminogen	Bos taurus	36-43
19118899-5	2009	Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1.	Lysine	37-43	recombination activating 1	Homo sapiens	74-78
19228710-3	2009	RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1-dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.	Lysine	163-169	tumor protein p53 binding protein 1	Homo sapiens	22-27
19228710-3	2009	RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1-dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.	Lysine	163-169	tumor protein p53 binding protein 1	Homo sapiens	63-68
19228710-3	2009	RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1-dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.	Lysine	163-169	tumor protein p53 binding protein 1	Homo sapiens	63-68
19228710-4	2009	A monoubiquitination-resistant 53BP1 mutant harboring a substitution at lysine 1268 is not retained efficiently at the chromatin in the vicinity of DSBs.	Lysine	72-78	tumor protein p53 binding protein 1	Homo sapiens	31-36
19282482-0	2009	Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.	Lysine	52-58	KMT5A pseudogene 1	Homo sapiens	38-42
19282482-3	2009	SET7 colocalizes and directly interacts with DNMT1 and specifically monomethylates Lys-142 of DNMT1.	Lysine	83-86	KMT5A pseudogene 1	Homo sapiens	0-4
19351588-0	2009	Multiple lysine methylation of PCAF by Set9 methyltransferase.	Lysine	9-15	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	39-43
19351588-4	2009	In vitro mapping experiments revealed six lysine residues could be methylated by Set9.	Lysine	42-48	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	81-85
20641344-11	2004	The tumor homing peptide cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys (cNGR) contains the Asn-Gly-Arg (NGR) motif that binds to APN (11).	Lysine	56-59	alanyl (membrane) aminopeptidase	Mus musculus	118-121
19074424-0	2009	The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.	Lysine	35-41	thrombomodulin	Homo sapiens	112-126
19074424-6	2009	When the three consecutive lysine residues in the activation peptide of TAFI were substituted with alanine (K42/43/44A), the catalytic efficiencies for TAFI activation with TM decreased 8-fold.	Lysine	27-33	thrombomodulin	Homo sapiens	173-175
19135027-6	2009	Arg(671), Lys(712)/Lys(713) and Lys(728) were also found to modulate the ETF.	Lysine	10-13	TEA domain transcription factor 2	Homo sapiens	73-76
19135027-6	2009	Arg(671), Lys(712)/Lys(713) and Lys(728) were also found to modulate the ETF.	Lysine	19-22	TEA domain transcription factor 2	Homo sapiens	73-76
19135027-6	2009	Arg(671), Lys(712)/Lys(713) and Lys(728) were also found to modulate the ETF.	Lysine	19-22	TEA domain transcription factor 2	Homo sapiens	73-76
19223185-1	2009	The ATP-dependent Mur ligases (MurC, MurD, MurE and MurF) successively add L-Ala, D-Glu, meso-A(2)pm or L-Lys, and D-Ala-D-Ala to the nucleotide precursor UDP-MurNAc, and they represent promising targets for antibacterial drug discovery.	Lysine	104-109	tripartite motif containing 54	Homo sapiens	52-56
19074500-7	2009	Lastly, levels of trimethylated lysine 27 at histone H3 in blastocysts were higher in bovine nuclear transfer embryos activated using cycloheximide and 6-dimethylaminopurine (DMAP) than in those activated using PLCZ or derived from IVF.	Lysine	32-38	phospholipase C zeta 1	Bos taurus	211-215
19232136-6	2009	We further demonstrated that trimethylation of histone 3 lysine 27 (H3K27me3) is involved in the miR-10a-induced hoxd4 transcriptional gene silence.	Lysine	57-63	microRNA 10a	Homo sapiens	97-104
19232136-6	2009	We further demonstrated that trimethylation of histone 3 lysine 27 (H3K27me3) is involved in the miR-10a-induced hoxd4 transcriptional gene silence.	Lysine	57-63	homeobox D4	Homo sapiens	113-118
19073596-0	2009	MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines.	Lysine	130-137	eukaryotic translation initiation factor 3 subunit F	Homo sapiens	63-69
19073596-4	2009	Site-directed mutagenesis of eIF3-f revealed that the six lysine residues within this domain are required for full polyubiquitination and degradation by the proteasome.	Lysine	58-64	eukaryotic translation initiation factor 3 subunit F	Homo sapiens	29-35
19203578-6	2009	RNF168 acts with UBC13 to amplify the RNF8-dependent histone ubiquitylation by targeting H2A-type histones and by promoting the formation of lysine 63-linked ubiquitin conjugates.	Lysine	141-147	ubiquitin conjugating enzyme E2 N	Homo sapiens	17-22
19203578-6	2009	RNF168 acts with UBC13 to amplify the RNF8-dependent histone ubiquitylation by targeting H2A-type histones and by promoting the formation of lysine 63-linked ubiquitin conjugates.	Lysine	141-147	ring finger protein 8	Homo sapiens	38-42
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	tumor protein p53 binding protein 1	Homo sapiens	247-252
19193875-2	2009	Removal of the tail domain and lysine-serine-proline (KSP) repeats of NF-M, but not neurofilament heavy, produced axons with impaired radial growth and reduced conduction velocities.	Lysine	31-37	neurofilament, medium polypeptide	Mus musculus	70-74
18984904-7	2009	Phylogenetic analyses and the presence of a lysine residue corresponding to position 90 in bovine rhodopsin suggested that three of the branchiopod opsins comprise UV-sensitive pigments.	Lysine	44-50	rhodopsin	Bos taurus	98-107
19015261-6	2009	We have further identified two functional degradation motifs in Sgo1; that is, a KEN (Lys-Glu-Asn) box and a destruction box (D box).	Lysine	86-89	shugoshin 1	Homo sapiens	64-68
19135889-4	2009	SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters.	Lysine	76-82	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	35-39
18824138-1	2009	The Rad6-Rad18 complex mono-ubiquitinates proliferating cell nuclear antigen (PCNA) at the lysine 164 residue after DNA damage and promotes DNA polymerase eta (Poleta)- and Polzeta/Rev1-dependent DNA synthesis.	Lysine	91-97	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	4-8
18824138-1	2009	The Rad6-Rad18 complex mono-ubiquitinates proliferating cell nuclear antigen (PCNA) at the lysine 164 residue after DNA damage and promotes DNA polymerase eta (Poleta)- and Polzeta/Rev1-dependent DNA synthesis.	Lysine	91-97	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	181-185
19205976-1	2009	beta-Globin haplotypes have been used to investigate the origin and spread of beta-globin mutations such as Hb S [beta 6(A3)Glu--&gt;Val, GAG&gt;GTG], Hb E [beta 26(B8)Glu--&gt;Lys, GAG&gt;AAG], and beta-thalassemia (beta-thal).	Lysine	177-180	hemoglobin subunit beta	Homo sapiens	0-11
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	49-52	mannose binding lectin 2	Homo sapiens	165-168
19079244-6	2009	IR treatments lead to a global increase in the acetylation of Lys 14 of histone H3 (H3K14) in an HMGN1-dependent manner and treatment of cells with histone deacetylase inhibitors bypasses the HMGN1 requirement for efficient ATM activation.	Lysine	62-65	ATM serine/threonine kinase	Homo sapiens	224-227
18996021-1	2008	Cyclization by double reductive amination of L-arabino-hexos-5-ulose with suitably protected D- as well as L-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5.	Lysine	107-115	complement C5	Homo sapiens	221-224
19066219-9	2008	The alpha-synuclein helix extends parallel to the curved membrane in a manner that allows conserved Lys and Glu residues to interact with the zwitterionic headgroups, while uncharged residues penetrate into the acyl chain region.	Lysine	100-103	synuclein alpha	Homo sapiens	4-19
19072264-6	2008	The stability of the 1:1 complexes between lysine, diphenylalanine, Ang III, and LeuEnk and DPPC were evaluated by varying the temperature of the heated capillary of the mass spectrometer.	Lysine	43-49	prodynorphin	Homo sapiens	81-87
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Lysine	167-170	ret proto-oncogene	Homo sapiens	109-112
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Lysine	194-197	ret proto-oncogene	Homo sapiens	109-112
7543205-7	1995	With a higher degree of labelling the affinities of both Fab fragments decreased more than that of the intact IgG since more lysine residues are available for labelling in the additional heavy chain constant domains of the larger molecule.	Lysine	125-131	FA complementation group B	Homo sapiens	57-60
7543205-8	1995	Electrostatic adsorption and covalent immobilization of the Fab fragments were characterized by BIAcore and the lysine-enriched Fab fragment was found to be more efficiently immobilized to an activated carboxymethyl surface.	Lysine	112-118	FA complementation group B	Homo sapiens	60-63
7543205-8	1995	Electrostatic adsorption and covalent immobilization of the Fab fragments were characterized by BIAcore and the lysine-enriched Fab fragment was found to be more efficiently immobilized to an activated carboxymethyl surface.	Lysine	112-118	FA complementation group B	Homo sapiens	128-131
7630885-0	1995	Alteration of the amino acid substrate specificity of clostridial glutamate dehydrogenase by site-directed mutagenesis of an active-site lysine residue.	Lysine	137-143	glutamate dehydrogenase 1	Homo sapiens	66-89
8744698-0	1995	Influence of Lys-residue deletion on the immunomodulatory activity of peptides related to immunosuppressive region of lactoferrin.	Lysine	13-16	lactotransferrin	Mus musculus	118-129
8744698-5	1995	On the contrary, the similar change within Arg-Lys-Pro-Val-Thr sequence, derived of 575-589 loop of LF, produces a tetrapeptide Arg-Pro-Val-Thr, that is active as immunosuppressor both in humoral and cellular immune response.	Lysine	47-50	lactotransferrin	Mus musculus	100-102
8744698-7	1995	The data presented herein indicate that exclusion of Lys residue from the LF-derived immunomodulatory peptides differentially alters their effects on the immune response to SRBC in mice.	Lysine	53-56	lactotransferrin	Mus musculus	74-76
7735142-0	1995	Effect of a p-nitro group of phenyl-maltooligosaccharide substrate on the change of action specificity of lysine-modified porcine pancreatic alpha-amylase.	Lysine	106-112	amylase alpha 2A	Homo sapiens	130-154
7735142-1	1995	The effect of chemical modification of lysine residues on the activity of porcine pancreatic alpha-amylase (PPA) was examined, using p-nitrophenyl-alpha-D-maltoside, p-nitrophenyl-alpha-D-maltotrioside, phenyl-alpha-D-maltoside and phenyl-alpha-D-maltotrioside as substrates.	Lysine	39-45	amylase alpha 2A	Homo sapiens	82-106
7587650-4	1995	Several linear peptides, incorporating the critical core-D-Trp-Lys-sequence of all active analogues, exhibit selectivity for either sstr3, sstr5 or both, but little affinity for the other three.	Lysine	63-66	somatostatin receptor 3	Rattus norvegicus	132-137
7966558-2	1994	We previously analyzed the quasispecies of the third hypervariable region (V3) in the viral envelope glycoprotein gp120 in an infected individual and found that the species with a basic amino acid substitution (lysine for aspartic acid) at a particular position evolved and became a distinct population within a short period, followed by progression to the typical immunodeficiency stage (S. Oka et al., AIDS Res.	Lysine	211-217	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	114-119
7961669-2	1994	We have previously shown that a decapeptide sequence between Lys-243 and Glu-252 (KYSFNYDGSE) in the third immunoglobulin (Ig)-like domain of chick neural cell adhesion molecule NCAM is directly involved in NCAM-to-NCAM binding.	Lysine	61-64	neural cell adhesion molecule 1	Gallus gallus	178-182
7713746-0	1994	Two new alpha chain variants found during glycated hemoglobin screening: Hb Tatras [alpha 7(A5)Lys-->Asn] and HB Lisbon [alpha 23(B4)Glu-->Asp].	Lysine	95-98	immunoglobulin kappa variable 2D-26	Homo sapiens	73-94
7962116-8	1994	By cleavage of the B subunit at the single tryptophan residue, the reduced Gb3 binding and lack of cellular internalization was shown to be due to the biotinylation of lysine 53 in the VT1 B subunit.	Lysine	168-174	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	75-78
8000011-1	1994	The rate-limiting step in the pathway for lysine synthesis in plants is catalyzed by the enzyme dihydrodipicolinate synthase (DS).	Lysine	42-48	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Glycine max	96-124
7948863-3	1994	The lti45 gene product contains the conserved serine stretch and three lysine-rich repeats characteristic of DHN/LEA/RAB proteins and is very similar to another low temperature-responsive protein of A. thaliana, COR47 [17].	Lysine	71-77	Dehydrin family protein	Arabidopsis thaliana	4-9
8062449-2	1994	Single site-specific mutations at lysine 58 and serine 61 produced a major decrease (50-100%) in reactivity of polyclonal IgM RF with beta 2m.	Lysine	34-40	beta-2-microglobulin	Homo sapiens	134-141
7529922-2	1994	To test possible mechanisms of antigen-antibody recognition and specificity computationally, we have used a Metropolis Monte Carlo algorithm to dock fragments of the epitope Glu-Val-Val-Pro-His-Lys-Lys to the X-ray structures of both the free and the complexed Fab of the antibody B13I2 (raised against the C-helix of myohemerythrin).	Lysine	198-201	FA complementation group B	Homo sapiens	261-264
8063713-9	1994	The third substrate, NFF-3 (Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2), was hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but there was no significant hydrolysis by MMP-1 and MMP-2.	Lysine	40-43	matrix metallopeptidase 1	Homo sapiens	239-244
8034630-0	1994	Role of highly conserved lysine 130 of myosin motor domain.	Lysine	25-31	myosin heavy chain 14	Homo sapiens	39-45
8034630-2	1994	We have created a mutant Dictyostelium myosin II heavy chain gene in which a highly conserved lysine residue (Lys-130) is changed to leucine.	Lysine	94-100	myosin heavy chain 14	Homo sapiens	39-45
8034630-2	1994	We have created a mutant Dictyostelium myosin II heavy chain gene in which a highly conserved lysine residue (Lys-130) is changed to leucine.	Lysine	110-113	myosin heavy chain 14	Homo sapiens	39-45
8034630-3	1994	Lys-130 is a residue that is known to be trimethylated in skeletal muscle myosin and had been thought to play an integral role in the interaction of myosin with ATP during the actomyosin chemomechanical cycle.	Lysine	0-3	myosin heavy chain 14	Homo sapiens	74-80
8043603-2	1994	The amino-acid sequences differ only by 13 residues, out of which two Lys residues of PRS I at positions 4 and 152 give net additional positive charges to PRS I.	Lysine	70-73	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	86-91
8043603-2	1994	The amino-acid sequences differ only by 13 residues, out of which two Lys residues of PRS I at positions 4 and 152 give net additional positive charges to PRS I.	Lysine	70-73	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	155-160
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	9-12	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	18-23
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	9-12	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	114-119
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	9-12	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	114-119
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	137-140	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	18-23
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	137-140	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	114-119
8043603-5	1994	Changing Lys-4 of PRS I to Val, together with Ile-5 to Leu, completely abolished sensitivity to GDP inhibition of PRS I, indicating that Lys-4 in PRS I is critical for GDP inhibition.	Lysine	137-140	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	114-119
8043603-8	1994	Lys-4 was also important for the strong ADP inhibition of PRS I.	Lysine	0-3	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	58-63
8043603-9	1994	Regarding the physical properties, chimeric enzymes bearing residues 12-53 of PRS I were stable at 49 degrees C and with digestion with papain and proteinase K. Our observations suggest that Lys-17, Ile-18, and/or Cys-40 of PRS I contribute to stability of the enzyme.	Lysine	191-194	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	78-83
8043021-7	1994	Both proteins contain one alpha amino group but only the human-EGF contains lysine residues with epsilon amino groups.	Lysine	76-82	epidermal growth factor	Homo sapiens	63-66
7960400-0	1994	New, highly active antagonists of LHRH with acylated lysine and p-aminophenylalanine in positions 5 and 6.	Lysine	53-59	gonadotropin releasing hormone 1	Rattus norvegicus	34-38
7960400-1	1994	A series of antagonists of the luteinizing hormone releasing hormone (LHRH) with substitutions in position 5 and/or 6 that included acylated lysine or p-aminophenylalanine were synthesized, characterized and tested for antiovulatory activity (AOA) in rats, and histamine releasing activity.	Lysine	141-147	gonadotropin releasing hormone 1	Rattus norvegicus	70-74
8175783-4	1994	In the first group (Group 1), replacement of His-699 by the basic amino acid Arg or Lys showed not only loss of EF-2 activity but also inhibitory effects on the growth of cells co-expressing wild-type EF-2.	Lysine	84-87	elongation factor 2	Saccharomyces cerevisiae S288C	112-116
8175783-4	1994	In the first group (Group 1), replacement of His-699 by the basic amino acid Arg or Lys showed not only loss of EF-2 activity but also inhibitory effects on the growth of cells co-expressing wild-type EF-2.	Lysine	84-87	elongation factor 2	Saccharomyces cerevisiae S288C	201-205
8170953-6	1994	Consequently, in human BPGM, we replaced by site-directed mutagenesis the corresponding amino acid residue Gly13 with an Arg or a Lys.	Lysine	130-133	bisphosphoglycerate mutase	Homo sapiens	23-27
7920863-3	1994	Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L).	Lysine	76-79	solute carrier family 3 member 2	Homo sapiens	19-24
7920863-3	1994	Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L).	Lysine	211-214	solute carrier family 3 member 2	Homo sapiens	19-24
8302588-4	1994	During the neoplastic progression a mutation was shown to occur in p53 gene at codon 130 (AAG &gt; AGG; Lys &gt; Arg) in a single cell which expanded and gave rise to a predominant subpopulation.	Lysine	104-107	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70
8262946-8	1993	Radiosequencing data verified that the production of the 5.3-kDa fragment by PC1 occurred as a result of a Lys-Lys cleavage.	Lysine	107-110	proprotein convertase subtilisin/kexin type 1	Homo sapiens	77-80
8262946-8	1993	Radiosequencing data verified that the production of the 5.3-kDa fragment by PC1 occurred as a result of a Lys-Lys cleavage.	Lysine	111-114	proprotein convertase subtilisin/kexin type 1	Homo sapiens	77-80
8262956-6	1993	The rate constants were 4,800, 6,800, 22,000, and 22,000 s-1 for cytochrome c derivatives modified at lysines 13, 27, 25, and 72, respectively.	Lysine	102-109	cytochrome c, somatic	Equus caballus	65-77
8299962-5	1993	The first Leu of the putative leucine zipper of D. melanogaster PARP is substituted to Lys in X. laevis PARP.	Lysine	87-90	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	64-68
8257710-6	1993	Fluorescein isothiocyanate- and cyclohexanedione-modified Lf competed fully with native Lf for binding and endocytosis, indicating that, unlike human Lf, modification of lysine or arginine residues does not block the interaction of bovine Lf with cells.	Lysine	170-176	lactotransferrin	Bos taurus	58-60
8258527-6	1993	A lysine residue, analogous to the retinaldehyde attachment site in rhodopsin, is conserved in the seventh hydrophobic segment of the novel sequence.	Lysine	2-8	rhodopsin	Bos taurus	68-77
7848387-1	1993	We have been able to amplify the lysine binding pocket region of human apo(a) kringle type 5 starting from the DNA isolated from peripheral blood lymphocytes.	Lysine	33-39	aminopeptidase O (putative)	Homo sapiens	71-74
8250906-2	1993	The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr &gt; Ser &gt; Gly &gt; Gln &gt; Cys &gt; Asn &gt; Asp &gt; Val &gt; Phe &gt; Glu &gt; Lys &gt; Tyr &gt; Ala = Trp &gt; His &gt; Arg, suggesting the importance of end capping.	Lysine	189-192	neuropeptide Y	Homo sapiens	59-62
7690504-5	1993	Crystallographic data shows that a salt bridge exists between Asp 488 and Lys 465 of RNase H which stabilizes the uncleavable form of RT p66, and that substitution of Asp for Ala would prevent the formation of this salt bridge.	Lysine	74-77	DNA polymerase delta 3, accessory subunit	Homo sapiens	137-140
7690756-4	1993	The Apn1 C terminus is rich in basic amino acids and includes two lysine/arginine clusters related to the nuclear transport signals of some other proteins.	Lysine	66-72	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	4-8
8376414-1	1993	We have previously used synthetic peptides to identify a homophilic binding site between Lys-243 and Glu-252 (KYSFNYDGSE) in the third immunoglobulin-like domain of the chick neural cell adhesion molecule (NCAM).	Lysine	89-92	neural cell adhesion molecule 1	Gallus gallus	175-204
8376414-1	1993	We have previously used synthetic peptides to identify a homophilic binding site between Lys-243 and Glu-252 (KYSFNYDGSE) in the third immunoglobulin-like domain of the chick neural cell adhesion molecule (NCAM).	Lysine	89-92	neural cell adhesion molecule 1	Gallus gallus	206-210
8395505-7	1993	As expected, K2P showed enhanced plasminogen activation in the presence of CNBr fragments of fibrinogen, bound to lysine-Sepharose and to a forming fibrin clot.	Lysine	114-120	keratin 76	Homo sapiens	13-16
8282716-0	1993	In vitro motility of proteolytically cleaved myosin subfragment 1 on a lysine-coated surface.	Lysine	71-77	myosin heavy chain 14	Homo sapiens	45-51
8257803-2	1993	A tetrameric MAP with multiply incorporated overlapping B- and T-cell epitopes was combined with a particular HA sequence representing the slightly modified fusion peptide on the C-terminus of the Lys core (MAP-1).	Lysine	197-200	mannosidase processing 1	Mus musculus	207-212
8415938-4	1993	An increase in serum inhibin and activin A was observed in rats fed a Lys-sufficient and nonprotein diet, respectively.	Lysine	70-73	inhibin subunit beta A	Rattus norvegicus	33-42
8395206-1	1993	The reactions of bovine cytochrome c oxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)bis(bipyridine)ruthenium (II) were studied by laser flash photolysis.	Lysine	101-107	cytochrome c, somatic	Equus caballus	56-68
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Lysine	155-158	phosphoenolpyruvate carboxylase	Nicotiana tabacum	80-84
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Lysine	155-158	phosphoenolpyruvate carboxylase	Nicotiana tabacum	274-278
8344949-3	1993	Cathepsin G and chymotrypsin cleave the synthetic peptide HSEVKMDAEF at M/D under acidic conditions, whereas cleavage at lysine-methionine (K/M) predominates when the pH is alkaline.	Lysine	121-127	cathepsin G	Homo sapiens	0-11
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	Lysine	140-146	glutathione S-transferase pi 1	Homo sapiens	54-61
8393791-2	1993	Site-specific reaction was achieved by cross-linking conserved lysine residues close to the G-nucleotide binding site of p21 with the 2",3"-dialdehyde derivatives of GDP or GTP under kinetically controlled conditions.	Lysine	63-69	H3 histone pseudogene 16	Homo sapiens	121-124
8399528-3	1993	An hydroxysuccinimide ester analogue of ICI 200,880 was coupled to the lysine residues of bovine serum albumin, characterized by gel electrophoresis and injected into rabbits to stimulate antibody formation; a highly specific, high titre antibody was obtained.	Lysine	71-77	albumin	Oryctolagus cuniculus	97-110
8373732-4	1993	Surprisingly, these lysines are conserved among several src family members.	Lysine	20-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
8493555-2	1993	Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with target cells that were homozygous for HLA-C(Ser77,Asn80); the reciprocal stimulation yielded NK cells specific for the NK-2 alloantigen.	Lysine	170-176	tachykinin receptor 1	Homo sapiens	39-43
8506324-1	1993	The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences are observed with mutations at His-64 and Val-68 as well as with temperature and pH.	Lysine	115-118	myoglobin	Homo sapiens	56-65
8383684-3	1993	Peptides derived from the sequence of RK were used to prepare site-specific anti-peptide antibodies against: 1) the N-terminal region located between residues 17 and 34, which contains an autophosphorylation site; 2) the Lys/Arg-rich region corresponding to residues 216-237 near the catalytic domain; 3) the region located between residues 483 and 497, which encompasses the major autophosphorylation sites; and 4) the C-terminal region located between residues 539 and 556, close to the isoprenylation site of RK.	Lysine	221-224	G protein-coupled receptor kinase 1	Homo sapiens	38-40
8097117-11	1993	Lys 394 in a human keratinocyte alpha-tubulin (k alpha 1) was replaced by a glutamic acid residue using site-directed mutagenesis.	Lysine	0-3	tubulin alpha 1b	Homo sapiens	32-45
8097117-11	1993	Lys 394 in a human keratinocyte alpha-tubulin (k alpha 1) was replaced by a glutamic acid residue using site-directed mutagenesis.	Lysine	0-3	tubulin alpha 1b	Homo sapiens	47-56
8382508-6	1993	PCR/DNA sequence analysis and allele-specific hybridisation showed that one of two TOP2 alpha alleles expressed in CEM/VP-1 cells had acquired a Lys-797--&gt;Asn codon change.	Lysine	145-148	DNA topoisomerase II alpha	Homo sapiens	83-93
8435081-7	1993	The values of Hyl/(Hyl+Lys) in bone collagen alpha 1(I) chains from treated mice were about 0.434-0.484, i.e. substantially higher than that of the control (0.277).	Lysine	23-26	megakaryocyte-associated tyrosine kinase	Mus musculus	14-17
8420976-7	1993	In contrast, the alpha 1-1 and alpha 1-3 mutants accumulated in both cytoplasm and nucleus, underscoring the importance of the Lys134-Arg-Lys residues for correct nuclear targeting.	Lysine	127-130	adrenoceptor alpha 1D	Homo sapiens	17-40
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Lysine	176-179	insulin like growth factor 2	Homo sapiens	18-55
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Lysine	250-253	insulin like growth factor 2	Homo sapiens	18-55
1368920-4	1992	Moreover, when one amino acid (Ile155) in a beta-sheet of the DHFR C-terminal region was replaced with Lys, the enzymatically active DHFR fusion protein was secreted into the medium.	Lysine	103-106	Dihydrofolate reductase	Escherichia coli	62-66
1368920-4	1992	Moreover, when one amino acid (Ile155) in a beta-sheet of the DHFR C-terminal region was replaced with Lys, the enzymatically active DHFR fusion protein was secreted into the medium.	Lysine	103-106	Dihydrofolate reductase	Escherichia coli	133-137
1337603-1	1992	Latent protein phosphatase, Fc.M, was purified from porcine heart extracts by a procedure involving precipitation at pH 5.0, DEAE-Sephacel chromatography, ammonium sulfate fractionation, chromatography on phenyl-Sepharose, Biogel-A 0.5m and poly-L-lysine-agarose.	Lysine	241-254	nucleolar protein 3	Homo sapiens	28-32
1425958-1	1992	We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.	Lysine	26-31	neurotensin/neuromedin N	Cavia porcellus	202-213
1322913-0	1992	Lysine 356 is a critical residue for binding the C-6 phospho group of fructose 2,6-bisphosphate to the fructose-2,6-bisphosphatase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	Lysine	0-6	complement C6	Rattus norvegicus	49-52
1327167-1	1992	Carbodiimide-activated coupling chemistry has been used to covalently attach 1,1"-dicarboxyferrocene (dcFc) to the epsilon-amine of surface lysine residues of horse heart cytochrome c.	Lysine	140-146	cytochrome c, somatic	Equus caballus	171-183
1327167-4	1992	Through-space distances from these lysines to the nearest heme edge span the 6-16 A range and these derivatives should prove useful in exploring the distance dependence of long-range intramolecular electron transfer in cytochrome c.	Lysine	35-42	cytochrome c, somatic	Equus caballus	219-231
1516484-1	1992	OBJECTIVE: To develop a sensitive and reliable immunoreadiometric assay to measure glycosylated lysine residues on serum proteins (GSP) and to evaluate its efficacy in monitoring glycemic control.	Lysine	96-102	GSM1	Homo sapiens	131-134
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-112	cytochrome c, somatic	Equus caballus	73-85
1639630-8	1992	TCC B and I were restricted by HLA-DR molecules, and recognized the mutated p21 ras-derived peptide carrying Arg and Lys at residue 12, respectively.	Lysine	117-120	H3 histone pseudogene 16	Homo sapiens	76-79
1372908-0	1992	Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex.	Lysine	18-24	coagulation factor III, tissue factor	Homo sapiens	91-104
18929535-6	2008	Reactivation of MLH1 by MeTA accompanied acetylation of histone H3 lysine 9/14 at the promoter region.	Lysine	67-73	mutL homolog 1	Homo sapiens	16-20
19006282-6	2008	For both systems, Co+-lysine and Co2+-lysine, the most stable structure results from the interaction of neutral lysine to the metal cation through the two amino groups and the carbonyl oxygen, the ground electronic state being a 3A in the case of Co+ and 4A for the Co2+ system.	Lysine	22-28	complement C2	Homo sapiens	266-269
19001268-1	2008	Treatment of yeast and human cells with DNA-damaging agents elicits Rad6-Rad18-mediated monoubiquitination of proliferating cell nuclear antigen (PCNA) at its Lys-164 residue [ubiquitin (Ub)-PCNA], and this PCNA modification is indispensable for promoting the access of translesion synthesis (TLS) polymerases (Pols) to PCNA.	Lysine	159-162	proliferating cell nuclear antigen	Homo sapiens	110-144
19001268-1	2008	Treatment of yeast and human cells with DNA-damaging agents elicits Rad6-Rad18-mediated monoubiquitination of proliferating cell nuclear antigen (PCNA) at its Lys-164 residue [ubiquitin (Ub)-PCNA], and this PCNA modification is indispensable for promoting the access of translesion synthesis (TLS) polymerases (Pols) to PCNA.	Lysine	159-162	proliferating cell nuclear antigen	Homo sapiens	146-150
18849979-2	2008	Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69 of Swd2, the essential component of SET1/COMPASS in Saccharomyces cerevisiae.	Lysine	80-83	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	134-138
18849979-2	2008	Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69 of Swd2, the essential component of SET1/COMPASS in Saccharomyces cerevisiae.	Lysine	91-94	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	134-138
18765669-12	2008	The results explain the marked species difference in antagonist sensitivity and identify an ectodomain lysine residue that plays a key role in the binding of both suramin and NF449 to P2X(1) receptors.	Lysine	103-109	purinergic receptor P2X 1	Homo sapiens	184-190
18852463-5	2008	miR-320 directs the association of RNA interference (RNAi) protein Argonaute-1 (AGO1), Polycomb group (PcG) component EZH2, and tri-methyl histone H3 lysine 27 (H3K27me3) with the POLR3D promoter.	Lysine	150-156	RNA polymerase III subunit D	Homo sapiens	180-186
1554354-1	1992	The tripeptide sequence Trp-Lys-Ser (WKS) is repeated three times in the extracellular ligand binding domain of human Tissue Factor (TF).	Lysine	28-31	coagulation factor III, tissue factor	Homo sapiens	118-131
1554354-1	1992	The tripeptide sequence Trp-Lys-Ser (WKS) is repeated three times in the extracellular ligand binding domain of human Tissue Factor (TF).	Lysine	28-31	coagulation factor III, tissue factor	Homo sapiens	133-135
32449466-9	2021	It was found that Lys-MG and Lys-Gly induced an increase in P-selectin expression (p < .05), being 33.9% higher for Lys-MG when compared to Lys-Gly.	Lysine	18-21	selectin P	Homo sapiens	60-70
1549610-7	1992	The potassium dependence of macroscopic conductance in RCK4 channels was related by site-directed mutagenesis to that lysine residue in the extracellular loop between the transmembrane segments S5 and S6 of RCK4 protein that confers resistance to extracellular blockage by tetraethylammonium.	Lysine	118-124	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	55-59
1549610-7	1992	The potassium dependence of macroscopic conductance in RCK4 channels was related by site-directed mutagenesis to that lysine residue in the extracellular loop between the transmembrane segments S5 and S6 of RCK4 protein that confers resistance to extracellular blockage by tetraethylammonium.	Lysine	118-124	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	207-211
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Lysine	42-45	nei like DNA glycosylase 1	Homo sapiens	130-135
19080631-0	2008	[Histone H3 lysine 9 methylation is associated with the expression of hMLH1 and DNA methylation in gastric cancer cells].	Lysine	12-18	mutL homolog 1	Homo sapiens	70-75
32449466-9	2021	It was found that Lys-MG and Lys-Gly induced an increase in P-selectin expression (p < .05), being 33.9% higher for Lys-MG when compared to Lys-Gly.	Lysine	29-32	selectin P	Homo sapiens	60-70
1558197-3	1992	None of the SH reagents tested affected the flow-induced EDRF release, but DTDP and NEM inhibited the release of EDRF stimulated by ADP, ionomycin, or poly-L-lysine.	Lysine	151-164	alpha hemoglobin stabilizing protein	Homo sapiens	113-117
32313942-6	2020	HBXIP induced HMGA2 acetylation at the lysine 26 (K26), resulting in HMGA2 protein accumulation.	Lysine	39-45	high mobility group AT-hook 2	Homo sapiens	14-19
1311955-3	1992	Similar to its ligands, the amino acid sequence of the activin receptor is highly conserved with only two conservative amino acid differences (Lys-39 and Val-92 in human versus Arg-39 and Ile-92 in the mouse).	Lysine	143-146	inhibin subunit beta E	Homo sapiens	55-62
19080631-3	2008	Chromatin immunoprecipitation (ChIP) assay was used to assess the status of histone H3 lysine 9 methylation in the promoter regions of hMLH1 gene.	Lysine	87-93	mutL homolog 1	Homo sapiens	135-140
1733935-10	1992	The reaction of lysine 41 with methyl acetimidate resulted in a lysineacetamidine product which only partially restored activity of the lysine hEGF mutant.	Lysine	16-22	epidermal growth factor	Homo sapiens	143-147
32313942-6	2020	HBXIP induced HMGA2 acetylation at the lysine 26 (K26), resulting in HMGA2 protein accumulation.	Lysine	39-45	high mobility group AT-hook 2	Homo sapiens	69-74
1733935-10	1992	The reaction of lysine 41 with methyl acetimidate resulted in a lysineacetamidine product which only partially restored activity of the lysine hEGF mutant.	Lysine	64-70	epidermal growth factor	Homo sapiens	143-147
32551023-1	2020	The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4.	Lysine	67-73	lysine methyltransferase 2A	Homo sapiens	56-60
1281953-3	1992	In tissue fixed briefly in periodate-lysine-paraformaldehyde, tau immunoreactivity was detected in astrocytes, but only a few tau epitopes were detected in NFT with this fixation method.	Lysine	37-43	microtubule associated protein tau	Homo sapiens	62-65
18596036-9	2008	This information allows us to propose a model of the MBL-MASP-1/3 interaction, involving a major electrostatic interaction between two acidic Ca(2+) ligands of MASP-1/3 and a conserved lysine of MBL.	Lysine	185-191	mannose binding lectin 2	Homo sapiens	53-56
18596036-9	2008	This information allows us to propose a model of the MBL-MASP-1/3 interaction, involving a major electrostatic interaction between two acidic Ca(2+) ligands of MASP-1/3 and a conserved lysine of MBL.	Lysine	185-191	MBL associated serine protease 1	Homo sapiens	57-65
18617513-3	2008	In conjunction with the dimeric E2 enzyme Ubc13-Uev1A, the N-terminal RING domain of TRAF6 functions as an E3 ubiquitin (Ub) ligase that facilitates its own site-specific ubiquitination through the generation of a Lys-63-linked poly-Ub chain.	Lysine	214-217	ubiquitin conjugating enzyme E2 V1	Homo sapiens	48-53
18617513-3	2008	In conjunction with the dimeric E2 enzyme Ubc13-Uev1A, the N-terminal RING domain of TRAF6 functions as an E3 ubiquitin (Ub) ligase that facilitates its own site-specific ubiquitination through the generation of a Lys-63-linked poly-Ub chain.	Lysine	214-217	TNF receptor associated factor 6	Homo sapiens	85-90
32249212-6	2020	Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species.	Lysine	55-58	zinc finger homeobox 3	Homo sapiens	148-153
18478542-6	2008	A lysine-to-leucine substitution in this domain of L1 (K1147L) shows reduced binding to the ezrin FERM domain.	Lysine	2-8	ezrin	Homo sapiens	92-97
1732513-4	1992	Of the charged amino acids in the C"" and D strands of the amino-terminal domain of CD4, alteration of only two, lysine 46 and arginine 59, dramatically disrupted ability to bind gp120.	Lysine	113-119	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	179-184
32249212-3	2020	We have previously demonstrated that ZFHX3 is SUMOylated at three or more lysine residues.	Lysine	74-80	zinc finger homeobox 3	Homo sapiens	37-42
1751497-2	1991	Site-directed mutagenesis studies of bovine pancreatic phospholipase A2 (PLA2, overproduced in Escherichia coli) showed that replacement of surface residue Lys-56 by a neutral or hydrophobic amino acid residue resulted in an unexpected and significant change in the function of the enzyme.	Lysine	156-159	LOC104974671	Bos taurus	55-71
1751497-2	1991	Site-directed mutagenesis studies of bovine pancreatic phospholipase A2 (PLA2, overproduced in Escherichia coli) showed that replacement of surface residue Lys-56 by a neutral or hydrophobic amino acid residue resulted in an unexpected and significant change in the function of the enzyme.	Lysine	156-159	LOC104974671	Bos taurus	73-77
18583067-4	2008	Sequence analysis revealed that, like human LPTS/PinX1, the zLPTS protein has a conserved G-patch domain at its N-terminus and a lysine-rich domain at its C-terminus.	Lysine	129-135	PIN2 (TERF1) interacting telomerase inhibitor 1	Danio rerio	60-65
1751497-14	1991	264, 10041-10047] that substrate-level acylation of Lys-56 is an obligatory step in the catalysis by PLA2.	Lysine	52-55	LOC104974671	Bos taurus	101-105
32249212-6	2020	Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species.	Lysine	9-15	zinc finger homeobox 3	Homo sapiens	28-33
32249212-9	2020	SUMOylation at Lys-2806 enhanced ZFHX3 stability by interfering with its ubiquitination and proteasomal degradation.	Lysine	15-18	zinc finger homeobox 3	Homo sapiens	33-38
32249212-10	2020	Functionally, Lys-2806 SUMOylation enabled ZFHX3-mediated cell proliferation and xenograft tumor growth of the MDA-MB-231 breast cancer cell line.	Lysine	14-17	zinc finger homeobox 3	Homo sapiens	43-48
18486321-1	2008	The transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta) contains multiple acetylation sites, including lysine (K) 39.	Lysine	120-126	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	25-60
31883159-4	2020	Both SWI3B and HDA6 maintain transposon silencing by decreasing histone H3 lysine 9 acetylation, but increasing histone H3 lysine 9 di-methylation, DNA methylation and nucleosome occupancy.	Lysine	75-81	histone deacetylase 6	Arabidopsis thaliana	15-19
18486321-1	2008	The transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta) contains multiple acetylation sites, including lysine (K) 39.	Lysine	120-126	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	62-71
18614019-6	2008	We show that p400 localization to the promoters of both silent and active genes is dependent upon histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	109-115	E1A binding protein p400	Mus musculus	13-17
18614053-3	2008	Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of the cohesin complex that physically holds the sister chromatid together, at two conserved lysine residues.	Lysine	188-194	establishment of sister chromatid cohesion N-acetyltransferase 1	Homo sapiens	55-60
1756714-1	1991	Mutational analysis of p21ras has shown that plasma membrane targeting requires the combination of a CAAX motif with a polybasic domain of six lysine residues or a nearby palmitoylation site.	Lysine	143-149	HRas proto-oncogene, GTPase	Homo sapiens	23-29
1680853-0	1991	Interaction of gamma-glutamyl transpeptidase with glutathione involves specific arginine and lysine residues of the heavy subunit.	Lysine	93-99	gamma-glutamyltransferase 1	Rattus norvegicus	15-44
31883159-4	2020	Both SWI3B and HDA6 maintain transposon silencing by decreasing histone H3 lysine 9 acetylation, but increasing histone H3 lysine 9 di-methylation, DNA methylation and nucleosome occupancy.	Lysine	123-129	histone deacetylase 6	Arabidopsis thaliana	15-19
1908564-5	1991	An inward current was recorded electrophysiologically when a mixture of amino-acids was applied: this resulted from a stereoselective, saturable uptake of lysine, arginine and ornithine; it was independent of sodium and not substantially altered by gp70.	Lysine	155-161	embigin	Mus musculus	249-253
29185849-4	2020	Monoubiquitylation of KRAS at lysine 147 (mUbRAS) enhances Ras activation and promotes signaling through the RAF and Phosphoinositide 3-Kinase (PI3K) signaling pathways.	Lysine	30-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	117-142
1772311-5	1991	Human acrosin showed a broad substrate specificity for arginine and lysine derivatives and it seemed to have a somewhat different specificity from trypsin.	Lysine	68-74	acrosin	Homo sapiens	6-13
18471979-4	2008	Here, we show that ER is directly methylated at lysine 302 (K302) by the SET7 methyltransferase.	Lysine	48-54	KMT5A pseudogene 1	Homo sapiens	73-77
32112098-3	2020	MORC2 is acetylated by the acetyltransferase NAT10 at lysine 767 (K767Ac) and this process is counteracted by the deacetylase SIRT2 under unperturbed conditions.	Lysine	54-60	sirtuin 2	Homo sapiens	126-131
18408733-3	2008	Here, we demonstrate that arsenic-induced PML SUMOylation triggers its Lys 48-linked polyubiquitination and proteasome-dependent degradation.	Lysine	71-74	PML nuclear body scaffold	Homo sapiens	42-45
1850732-8	1991	Whereas the unmodified precursor ec-eIF-4D(Lys) appeared inactive, the deoxyhypusine-containing form provided a significant degree of stimulation.	Lysine	43-46	eukaryotic translation initiation factor 5A	Homo sapiens	36-42
32193337-6	2020	O-GlcNAcylation of threonine 136 on AHCY increases its activity and is important for the maintenance of trimethylation of histone H3 lysine 4 (H3K4me3) to sustain mESC pluripotency.	Lysine	133-139	S-adenosylhomocysteine hydrolase	Mus musculus	36-40
2022663-5	1991	We found 134 unique PAI-1 variants that retained inhibitory activity towards UK; they contained a variety of amino acids in their P3 and P2 positions but only Arg or, infrequently, Lys in their P1 position.	Lysine	181-184	serpin family E member 1	Homo sapiens	20-25
2016746-1	1991	A yeast nuclear gene, designated MSK1, has been selected from a yeast genomic library by transformation of a respiratory deficient mutant impaired in acylation of mitochondrial lysine tRNA.	Lysine	177-183	lysine--tRNA ligase MSK1	Saccharomyces cerevisiae S288C	33-37
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	96-99	microtubule affinity regulating kinase 4	Homo sapiens	76-81
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	microtubule affinity regulating kinase 4	Homo sapiens	76-81
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	microtubule affinity regulating kinase 4	Homo sapiens	76-81
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	microtubule affinity regulating kinase 4	Homo sapiens	76-81
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	171-174	microtubule affinity regulating kinase 4	Homo sapiens	60-65
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	179-182	microtubule affinity regulating kinase 4	Homo sapiens	60-65
1848239-10	1991	Both CDC34 and E2(32k) exhibit a marked kinetic selectivity for processive multiubiquitination via Lys-48 of ubiquitin.	Lysine	99-102	ubiquitin	Oryctolagus cuniculus	80-89
31891777-5	2020	We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites, some of which are removed by HDA9, resulting in inhibition of WRKY53 transcription activity.	Lysine	57-63	WRKY family transcription factor	Arabidopsis thaliana	14-20
1848244-6	1991	Both epsilon-aminocaproic acid and tranexamic acid prevented actin"s inhibition of plasmin, suggesting that accessible lysine residues of actin interact with the kringle (lysine-binding) regions of plasmin.	Lysine	119-125	actin	Oryctolagus cuniculus	61-66
1848244-6	1991	Both epsilon-aminocaproic acid and tranexamic acid prevented actin"s inhibition of plasmin, suggesting that accessible lysine residues of actin interact with the kringle (lysine-binding) regions of plasmin.	Lysine	119-125	actin	Oryctolagus cuniculus	138-143
1848244-6	1991	Both epsilon-aminocaproic acid and tranexamic acid prevented actin"s inhibition of plasmin, suggesting that accessible lysine residues of actin interact with the kringle (lysine-binding) regions of plasmin.	Lysine	171-177	actin	Oryctolagus cuniculus	61-66
1848244-6	1991	Both epsilon-aminocaproic acid and tranexamic acid prevented actin"s inhibition of plasmin, suggesting that accessible lysine residues of actin interact with the kringle (lysine-binding) regions of plasmin.	Lysine	171-177	actin	Oryctolagus cuniculus	138-143
18239056-2	2008	SREBP-1 activity is regulated by reversible acetylation at specific lysine residues.	Lysine	68-74	sterol regulatory element binding transcription factor 1	Homo sapiens	0-7
18383026-4	2008	The present study uses CE to assess conformational states of wt and cleaved beta(2)m (dK58-beta(2)m, beta(2)m cleaved at lysine-58, a modification found in the circulation of hemodialysis patients) in the presence of divalent metal ions.	Lysine	121-127	beta-2-microglobulin	Homo sapiens	76-84
18383026-4	2008	The present study uses CE to assess conformational states of wt and cleaved beta(2)m (dK58-beta(2)m, beta(2)m cleaved at lysine-58, a modification found in the circulation of hemodialysis patients) in the presence of divalent metal ions.	Lysine	121-127	beta-2-microglobulin	Homo sapiens	91-99
18383026-4	2008	The present study uses CE to assess conformational states of wt and cleaved beta(2)m (dK58-beta(2)m, beta(2)m cleaved at lysine-58, a modification found in the circulation of hemodialysis patients) in the presence of divalent metal ions.	Lysine	121-127	beta-2-microglobulin	Homo sapiens	91-99
31891777-5	2020	We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites, some of which are removed by HDA9, resulting in inhibition of WRKY53 transcription activity.	Lysine	57-63	WRKY family transcription factor	Arabidopsis thaliana	157-163
1993649-6	1991	In normal human LDL, there are about 50 Lys with pK 8.9 and 170 Lys with pK 10.5; an upper limit of 10 pK 8.9 Lys may be particularly involved in binding to the LDL receptor.	Lysine	40-43	low density lipoprotein receptor	Homo sapiens	161-173
32350732-1	2020	PURPOSE OF REVIEW: Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia (MLL) gene, are found in 10% and 5% of adult and children ALL cases, respectively.	Lysine	49-55	lysine methyltransferase 2A	Homo sapiens	87-92
1898734-3	1991	In the presence of Mn2+, alpha-lactalbumin was found to reduce the reactivities of lysines 93 and 181 and to increase the reactivities of one or more of lysines 230, 237, and 241.	Lysine	83-90	lactalbumin alpha	Bos taurus	25-42
1898734-3	1991	In the presence of Mn2+, alpha-lactalbumin was found to reduce the reactivities of lysines 93 and 181 and to increase the reactivities of one or more of lysines 230, 237, and 241.	Lysine	153-160	lactalbumin alpha	Bos taurus	25-42
1773057-3	1991	The cleavage following a pair of lysine residues yields gastrin 17.	Lysine	33-39	gastrin	Homo sapiens	56-63
18272573-2	2008	We have previously shown that, in addition to lysine ubiquitination, MIR1 has the unique ability of transferring ubiquitin onto MHC-I molecules lacking available lysine residues, in a cysteine-dependent manner.	Lysine	46-52	fibronectin type III and SPRY domain containing 1	Homo sapiens	69-73
32350732-1	2020	PURPOSE OF REVIEW: Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia (MLL) gene, are found in 10% and 5% of adult and children ALL cases, respectively.	Lysine	49-55	lysine methyltransferase 2A	Homo sapiens	166-169
18272573-2	2008	We have previously shown that, in addition to lysine ubiquitination, MIR1 has the unique ability of transferring ubiquitin onto MHC-I molecules lacking available lysine residues, in a cysteine-dependent manner.	Lysine	162-168	fibronectin type III and SPRY domain containing 1	Homo sapiens	69-73
32107878-4	2020	KDM3B overexpression in HT-1080 cells results in decreased histone H3 lysine 9 methylation.	Lysine	70-76	lysine demethylase 3B	Homo sapiens	0-5
18285465-1	2008	The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia.	Lysine	15-21	lysine methyltransferase 2A	Homo sapiens	135-138
1650724-2	1991	A mutant of the iso-1-cytochrome c gene from Saccharomyces cerevisiae has been constructed which contains an Arg codon, replacing the normal trimethylated Lys at position 77.	Lysine	155-158	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	16-21
32035087-8	2020	Exogenous treatment with alpha-KG reduced brown adipogenesis during the early phase of differentiation, and ChIP analysis revealed that IDH1-mediated alpha-KG reduced trimethylation of histone H3 lysine 4 in the promoters of genes associated with brown adipogenesis.	Lysine	196-202	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	136-140
2229057-4	1990	This amino acid is part of the ATIII region comprising residues 114-154, which contains the highest proportion of basic residues (Arg or Lys), and is known from chemical modification studies to be involved in heparin binding.	Lysine	137-140	serpin family C member 1	Homo sapiens	31-36
2229057-8	1990	We propose that a cooperation between Lys-125, Arg-129, Lys-136, and Arg-47 exposed at the surface of the inhibitor allows the binding of the essential pentasaccharide domain of heparin which is specific for the ATIII interaction.	Lysine	38-41	serpin family C member 1	Homo sapiens	212-217
2229057-8	1990	We propose that a cooperation between Lys-125, Arg-129, Lys-136, and Arg-47 exposed at the surface of the inhibitor allows the binding of the essential pentasaccharide domain of heparin which is specific for the ATIII interaction.	Lysine	56-59	serpin family C member 1	Homo sapiens	212-217
18311969-5	2008	It is found that the binding of the methylated lysine substrate in the active site of SET7/ 9 opens up the cofactor AdoMet binding channel so that solvent water molecules get access to the active site.	Lysine	47-53	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	86-93
18311969-6	2008	This disrupts the catalytic machinery of SET7/9 for the di-methylation reaction, which leads to a higher activation barrier, whereas for the LSMT, its active site is more spacious than that of SET7/9, so that the methylated lysine substrate can be accommodated without interfering with its catalytic power.	Lysine	224-230	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	41-47
18311969-6	2008	This disrupts the catalytic machinery of SET7/9 for the di-methylation reaction, which leads to a higher activation barrier, whereas for the LSMT, its active site is more spacious than that of SET7/9, so that the methylated lysine substrate can be accommodated without interfering with its catalytic power.	Lysine	224-230	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	193-199
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	catenin beta 1	Homo sapiens	79-91
32317093-4	2020	Acetylation status of histone H4 on lysine K5, K6, K12 and K16 was assessed by immunohistochemistry.	Lysine	36-42	LOC781223	Bos taurus	22-32
18264770-1	2008	The aim of the present work was to perform a combined analysis of the degree of activation of the anterior hypothalamus of the rat and expression of the interleukin-2 gene during treatments of different types: mild stress ("handling") and adaption to it, as well as intranasal administration of physiological saline and the peptides Vilon (Lys-Glu) and Epitalon (Ala-Glu-Asp-Gly).	Lysine	340-343	interleukin 2	Rattus norvegicus	153-166
2205476-5	1990	The size of the digested product was consistent with a cleavage of pro-NPY resulting in an immunoreactive species, NPY-Gly-Lys.	Lysine	123-126	neuropeptide Y	Homo sapiens	71-74
2205476-5	1990	The size of the digested product was consistent with a cleavage of pro-NPY resulting in an immunoreactive species, NPY-Gly-Lys.	Lysine	123-126	neuropeptide Y	Homo sapiens	115-118
32124883-1	2020	Histone lysine methylation regulates the recruitment of mammalian DNA repair factor 53BP1 to the histone H4 lysine 20 (H4K20), through specific recognition of the tandem Tudor domain of 53BP1.	Lysine	8-14	tumor protein p53 binding protein 1	Homo sapiens	84-89
2144289-3	1990	The linkage site of the analog to the opsin was confirmed to be Lys-296 as in 11-cis-retinal rhodopsin.	Lysine	64-67	rhodopsin	Bos taurus	93-102
18284681-4	2008	While PCNA monoubiquitination leads to error-prone bypass via TLS, biochemical studies have identified MMS2 along with its heteromeric partner UBC13 to govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb).	Lysine	227-233	ubiquitin conjugating enzyme E2 V2	Homo sapiens	103-107
18284681-4	2008	While PCNA monoubiquitination leads to error-prone bypass via TLS, biochemical studies have identified MMS2 along with its heteromeric partner UBC13 to govern the error-free repair of DNA lesions by catalyzing the formation of lysine 63-linked polyubiquitin chains (K63-polyUb).	Lysine	227-233	ubiquitin conjugating enzyme E2 N	Homo sapiens	143-148
17668447-6	2008	As an illustration, we propose blocking of phosphorylation by O-GlcNAc modification on Ser 10, which may result in gene silencing in the presence of methylated Lys 9.	Lysine	160-163	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	62-70
2124504-0	1990	Role of lysine-54 in determining cofactor specificity and binding in human dihydrofolate reductase.	Lysine	8-14	dihydrofolate reductase	Homo sapiens	75-98
2124504-1	1990	Lysine-54 of human dihydrofolate reductase (hDHFR) appears to be involved in the interaction with the 2"-phosphate of NADPH and is conserved as a basic residue in other species.	Lysine	0-6	dihydrofolate reductase	Homo sapiens	19-42
2124504-1	1990	Lysine-54 of human dihydrofolate reductase (hDHFR) appears to be involved in the interaction with the 2"-phosphate of NADPH and is conserved as a basic residue in other species.	Lysine	0-6	dihydrofolate reductase	Homo sapiens	44-49
2124504-3	1990	A Lys-54 to Gln-54 mutant (K54Q) of hDHFR has been constructed by oligodeoxynucleotide-directed mutagenesis in order to study the role of Lys-54 in differentiating Km and Kcat values for NADPH and NADH as well as in other functions of hDHFR.	Lysine	2-5	dihydrofolate reductase	Homo sapiens	36-41
32124883-1	2020	Histone lysine methylation regulates the recruitment of mammalian DNA repair factor 53BP1 to the histone H4 lysine 20 (H4K20), through specific recognition of the tandem Tudor domain of 53BP1.	Lysine	8-14	tumor protein p53 binding protein 1	Homo sapiens	186-191
32124883-1	2020	Histone lysine methylation regulates the recruitment of mammalian DNA repair factor 53BP1 to the histone H4 lysine 20 (H4K20), through specific recognition of the tandem Tudor domain of 53BP1.	Lysine	108-114	tumor protein p53 binding protein 1	Homo sapiens	84-89
32124883-1	2020	Histone lysine methylation regulates the recruitment of mammalian DNA repair factor 53BP1 to the histone H4 lysine 20 (H4K20), through specific recognition of the tandem Tudor domain of 53BP1.	Lysine	108-114	tumor protein p53 binding protein 1	Homo sapiens	186-191
32108856-6	2020	The TLS ability of AtPolIB is mapped to two conserved lysine residues: K593 and K866.	Lysine	54-60	polymerase gamma 1	Arabidopsis thaliana	19-26
2177733-7	1990	The present models of mu- and delta-conformations share geometrical similarity with the low-energy structures of Leu-enkephalin and the Tyr-D-Lys-Gly-Phe-analogue.	Lysine	142-145	prodynorphin	Homo sapiens	113-127
31948749-4	2020	In addition, we observed that WDR5 promoted the binding of Myc to CARM1 promoter by interacting with Myc and inducing histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	128-134	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-62
2261441-2	1990	It is shown that the cationic oligopeptides octadeca(L-lysine) (Lys18) and octadeca(L-ornithine) (Orn18) can induce a parallel duplex for the natural DNA oligomer dT10 with thymine-thymine base pairs.	Lysine	53-61	Actin 57B	Drosophila melanogaster	163-167
18235233-4	2008	The 500 kD precursor MLL undergoes evolutionarily conserved site-specific cleavage mediated by Taspase1, generating the mature MLL(N320/C180) heterodimer which methylates histone H3 at lysine 4 with its carboxy-terminal SET domain.	Lysine	185-191	lysine methyltransferase 2A	Homo sapiens	21-24
18235233-4	2008	The 500 kD precursor MLL undergoes evolutionarily conserved site-specific cleavage mediated by Taspase1, generating the mature MLL(N320/C180) heterodimer which methylates histone H3 at lysine 4 with its carboxy-terminal SET domain.	Lysine	185-191	lysine methyltransferase 2A	Homo sapiens	127-130
32005763-6	2020	The SIRT1 action was associated with CaMKIIalpha downregulation and deacetylation of histone H3 lysine 9 at the CaMKIIalpha promoter.	Lysine	96-102	sirtuin 1	Mus musculus	4-9
18206177-3	2008	Antithrombin is one of the most important inhibitors of blood coagulation Since its activation by heparin binding requires critical interactions involving 3 Lys residues; we hypothesized that acrolein or homocysteine thiolactone impair antithrombin activity.	Lysine	157-160	serpin family C member 1	Homo sapiens	0-12
2223769-2	1990	The residues at Lys 344 and Arg 72 were previously suggested as salt bridge contacts in the cytochrome b5-cytochrome P-450cam association complex and implicated in the physiological putidaredoxin-cytochrome P-450cam complex [Stayton, P. S., Poulos, T. L., &amp; Sligar, S. G. (1989) Biochemistry 28, 8201-8205].	Lysine	16-19	cytochrome b5 type A	Homo sapiens	92-105
32139682-0	2020	A methylated lysine is a switch point for conformational communication in the chaperone Hsp90.	Lysine	13-19	heat shock protein 90 alpha family class A member 1	Homo sapiens	88-93
18198902-1	2008	Human monoamine oxidase A (hMAOA) is considered to be unique among mammalian MAOs in having a non-conservative Glu-X-Lys mutation (X being 151 in MAOAs and 142 in MAOB"s), which is suggested to be the reason for its monomeric structure.	Lysine	117-120	monoamine oxidase A	Homo sapiens	6-25
18198902-1	2008	Human monoamine oxidase A (hMAOA) is considered to be unique among mammalian MAOs in having a non-conservative Glu-X-Lys mutation (X being 151 in MAOAs and 142 in MAOB"s), which is suggested to be the reason for its monomeric structure.	Lysine	117-120	monoamine oxidase A	Homo sapiens	27-32
32139682-1	2020	Methylation of a conserved lysine in C-terminal domain of the molecular chaperone Hsp90 was shown previously to affect its in vivo function.	Lysine	27-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	82-87
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Lysine	91-94	interleukin 1 alpha	Homo sapiens	25-36
32139682-4	2020	Our results demonstrate that this particular lysine serves as a switch point for the regulation of Hsp90 functions by influencing its conformational cycle, ATPase activity, co-chaperone regulation, and client activation of yeast and human Hsp90.	Lysine	45-51	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	99-104
32139682-4	2020	Our results demonstrate that this particular lysine serves as a switch point for the regulation of Hsp90 functions by influencing its conformational cycle, ATPase activity, co-chaperone regulation, and client activation of yeast and human Hsp90.	Lysine	45-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	239-244
32139682-5	2020	Incorporation of the methylated lysine via genetic code expansion specifically shows that upon modification, the conformational cycle of Hsp90 is altered.	Lysine	32-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	137-142
18055523-5	2008	Western blot analysis showed that CT-1 increased phosphorylation of ERK1/2 MAP kinase, p38 MAP kinase, and Akt and that their inhibitors, PD-98059, SB-203580, and LY-294002, respectively, inhibited phosphorylation.	Lysine	163-165	cardiotrophin 1	Homo sapiens	34-38
2166559-8	1990	One isomer was similar in stability to the sulfone, while the other was intermediate in stability between the sulfone and des-Met proteins, the differences potentially interpretable in terms of the geometry of the Met-1-Lys-63 hydrogen bond.	Lysine	220-223	granzyme M	Homo sapiens	214-219
18055523-8	2008	CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide.	Lysine	86-88	cardiotrophin 1	Homo sapiens	0-4
32139682-6	2020	Molecular dynamics simulations including the methylated lysine suggest specific conformational changes that are propagated through Hsp90.	Lysine	56-62	heat shock protein 90 alpha family class A member 1	Homo sapiens	131-136
18055523-8	2008	CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide.	Lysine	86-88	C-C motif chemokine ligand 2	Homo sapiens	41-46
2324739-1	1990	Five phosphate-dependent monoclonal antibodies to the neurofilament heavy polypeptide bound strongly to a phosphorylated synthetic peptide, which contains a single Lys-Ser-Pro sequence that occurs in human neurofilaments.	Lysine	164-167	neurofilament heavy chain	Homo sapiens	54-85
32139682-7	2020	Thus, methylation of the C-terminal lysine allows a precise allosteric tuning of Hsp90 activity via long distances.	Lysine	36-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-86
32181366-5	2020	In contrast, two related SAK1 toxins, Hui1 and ShK, block KcsA and Kv1.3, respectively, via an arginine rather than the canonical lysine, when tethered and as free peptides.	Lysine	130-136	sedoheptulokinase	Homo sapiens	47-50
2319597-15	1990	The polarisation of C-O-1 and C-O-2 is assisted by the co-ordination of O-2 to cation [1] and O-1 to a lysine side-chain.	Lysine	103-109	complement C2	Homo sapiens	20-35
18077552-5	2008	We show that Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation.	Lysine	35-41	tumor susceptibility 101	Homo sapiens	84-90
32292498-15	2020	Increased levels of SIRT1 reduced nuclear factor kappaB (NF-kappaB) activity by decreasing the level of acetylation of Lysine 310, as well as inhibiting tumor necrosis factor-alpha (Tnf-alpha) and interleukin 1 (IL-1) expressions.	Lysine	119-125	sirtuin 1	Mus musculus	20-25
18218897-3	2008	In addition to the ectopic cytosine methylation, the ibm1 mutations induced a variety of developmental phenotypes, which depend on methylation of histone H3 at lysine 9.	Lysine	160-166	Transcription factor jumonji (jmjC) domain-containing protein	Arabidopsis thaliana	53-57
2342486-6	1990	The lysines flanking the intrachain half cystines are proposed as the likely candidates for crosslinking to IgG, thus delineating the immunoglobulin binding site of C1q.	Lysine	4-11	complement C1q A chain	Homo sapiens	165-168
2108725-7	1990	Similarly, the binding of myosin subfragment 1 to F-actin resulted in the dramatic broadening of the labeled Lys-61 resonances.	Lysine	109-112	myosin heavy chain 14	Homo sapiens	26-32
32017966-4	2020	Mutation of potential SUMOylation sites reveals that a lysine residue at amino acid position 12 of Gata6 serves as the major attachment site for SUMO.	Lysine	55-61	GATA binding protein 6	Homo sapiens	99-104
2108725-8	1990	Thus, Lys-61 on actin appears to be closely associated with the binding sites for both tropomyosin and myosin, suggesting that both these proteins can compete for the same site on actin.	Lysine	6-9	myosin heavy chain 14	Homo sapiens	92-98
2108725-9	1990	The other region of actin known to be involved in myosin binding, Cys-10, was found to be more remote from the actin-actin interfaces than Lys-61.	Lysine	139-142	myosin heavy chain 14	Homo sapiens	50-56
2110828-1	1990	The molar ratio dependent change in the binding manner between actin and the lysine-rich sequence at the junction between 50K and 20K domains of subfragment 1 was studied by both protease digestion and cross-linking with 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide.	Lysine	77-83	actin	Oryctolagus cuniculus	63-68
2110828-7	1990	It was found that the cross-linked sites were mainly at the first and second lysine residues of the lysine-rich sequence when the molar ratio of actin to subfragment 1 was 1:1.	Lysine	77-83	actin	Oryctolagus cuniculus	145-150
17981149-1	2008	We have previously isolated a mammalian homologue of Drosophila discsabsent, small, orhomeotic-1 (ash1) from the murine thymus, and recently shown that its SET domain methylates histone H3 lysine 36 (K36).	Lysine	189-195	absent, small, or homeotic discs 1	Drosophila melanogaster	98-102
2110828-7	1990	It was found that the cross-linked sites were mainly at the first and second lysine residues of the lysine-rich sequence when the molar ratio of actin to subfragment 1 was 1:1.	Lysine	100-106	actin	Oryctolagus cuniculus	145-150
32099474-2	2020	SET domain, bifurcated 2 (SETDB2) can mediate gene silencing by trimethylation of the ninth lysine residue of histone H3 protein (H3K9) of the promoter and has been confirmed as an oncogene in many cancers.	Lysine	92-98	SET domain bifurcated histone lysine methyltransferase 2	Homo sapiens	26-32
2140277-7	1990	We proposed that three basic amino acids corresponding to arginine 73 and lysines 82 and 96 in Escherichia coli thioredoxin play an important role in the anchorage of the thioredoxin to the negatively charged surface of the CF1 and are involved in the dual effect of KCl.	Lysine	74-81	thioredoxin	Homo sapiens	112-123
2140277-7	1990	We proposed that three basic amino acids corresponding to arginine 73 and lysines 82 and 96 in Escherichia coli thioredoxin play an important role in the anchorage of the thioredoxin to the negatively charged surface of the CF1 and are involved in the dual effect of KCl.	Lysine	74-81	thioredoxin	Homo sapiens	171-182
18544235-3	2008	To introduce amine groups, ELP was modified with lysine for conjugation with PS microbeads functionalized with carboxylic groups.	Lysine	49-55	nuclear receptor subfamily 5 group A member 1	Homo sapiens	27-30
32117920-2	2020	We have developed the first one-pot bio-orthogonal flexizyme system in which both acetyl-lysine (AcK) and non-hydrolysable thioacetyl-lysine (ThioAcK) were site-specifically incorporated into human histone H3 and H4 at different lysine positions in vitro, either individually or in pairs.	Lysine	89-95	tyrosine kinase non receptor 2	Homo sapiens	97-100
18946766-3	2008	By using site-directed mutagenesis, this report shows that the loss of lysine-241, K241A D(2) DAR reduced the amount of membrane-associated D(2) DAR.	Lysine	71-77	adrenoceptor alpha 1D	Homo sapiens	94-97
18946766-3	2008	By using site-directed mutagenesis, this report shows that the loss of lysine-241, K241A D(2) DAR reduced the amount of membrane-associated D(2) DAR.	Lysine	71-77	adrenoceptor alpha 1D	Homo sapiens	145-148
18946766-6	2008	These data provide the factual evidence that a loss of lysine-241 of the D(2) DAR affects receptor ubiquitination and renders the protein susceptible to the proteasomal degradation.	Lysine	55-61	adrenoceptor alpha 1D	Homo sapiens	78-81
2126195-7	1990	Using modified peptides we have shown that lysine or arginine is crucial for the interaction with HLA B27.	Lysine	43-49	major histocompatibility complex, class I, B	Homo sapiens	98-105
32093598-10	2020	Dynamic light scattering demonstrated that the single peaks, reflecting the complexes TMV-N-lys/DHFR-M2e were significantly shifted relative to the control TMV-N-lys virions.	Lysine	92-95	dihydrofolate reductase	Homo sapiens	96-100
1701920-1	1990	Sequence studies indicate that the alpha-1 domain of the HLA-B27 molecule has a characteristic unpaired cysteine residue at position 67, adjacent, because of secondary structure, to a lysine at position 70.	Lysine	184-190	major histocompatibility complex, class I, B	Homo sapiens	57-64
18936552-2	2008	Activated TAFI (TAFIa) cleaves carboxyl-terminal lysine residues from partially degraded fibrin, rendering it resistant to fibrinolysis by endogenous tissue plasminogen activator (tPA).	Lysine	49-55	plasminogen activator, tissue type	Rattus norvegicus	150-178
18985155-4	2008	Among other mechanisms, Myc recruits histone acetyl-transferases to target chromatin and locally promotes hyper-acetylation of multiple lysines on histones H3 and H4, although the identity and combination of the modified lysines is unknown.	Lysine	136-143	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	24-27
18985155-4	2008	Among other mechanisms, Myc recruits histone acetyl-transferases to target chromatin and locally promotes hyper-acetylation of multiple lysines on histones H3 and H4, although the identity and combination of the modified lysines is unknown.	Lysine	221-228	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	24-27
18985155-6	2008	Here, we used quantitative chromatin immunoprecipitation (qChIP) to profile a total of 24 lysine-acetylation and -methylation marks modulated by Myc at target promoters in a human B-cell line with a regulatable c-myc transgene.	Lysine	90-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	145-148
18985155-7	2008	Myc binding promoted acetylation of multiple lysines, primarily of H3K9, H3K14, H3K18, H4K5 and H4K12, but significantly also of H4K8, H4K91 and H2AK5.	Lysine	45-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
33769697-5	2021	Mechanistically, NEDD4L directly interacts with GP130 and mediates its Lys-27-linked ubiquitination and proteasomal degradation.	Lysine	71-74	interleukin 6 cytokine family signal transducer	Homo sapiens	48-53
31811786-10	2020	Moreover, ING4 could block nuclear factor-kappa B (NF-kappaB) P65 nuclear translocation and restrict P65 acetylation at lysine 310 induced by LPS treatment.	Lysine	120-126	inhibitor of growth family, member 4	Mus musculus	10-14
33793949-5	2021	Loss of cICDH resulted in increases of overall histone H3 lysine 4 trimethylation (H3K4me3) and enhanced mutation defects of the H3K4me3 demethylase gene JMJ14.	Lysine	58-64	cytosolic NADP+-dependent isocitrate dehydrogenase	Arabidopsis thaliana	8-13
33820827-6	2021	The inhibitor structure and its putative model show that the P1-Arg inserts into the S1 pocket, whereas the P2-Lys and P4-Arg interacts with the Asp/Glu-rich 99-loop that is unique to MSPL.	Lysine	111-114	transmembrane serine protease 13	Homo sapiens	184-188
31981571-6	2020	The objective of this study was to determine the effects of mimicking acetylation at a single site of cTnI (lysine-132; K132) on myofilament, myofibril, and cellular mechanics and elucidate its influence on molecular function.	Lysine	108-114	troponin I3, cardiac type	Rattus norvegicus	102-106
19112497-4	2008	In order to assess independently the E3 ligase and ubiquitin substrate functions of TRAF6, we generated, respectively, RING domain and complete lysine-deficient TRAF6 mutants.	Lysine	144-150	TNF receptor associated factor 6	Homo sapiens	161-166
19112497-6	2008	Likewise, lysine-deficient TRAF6 was found to interact with the TAK1-TAB1-TAB2 complex, but surprisingly was also found to be fully competent to activate TAK1, as well as NFkappaB and AP-1 reporters.	Lysine	10-16	TNF receptor associated factor 6	Homo sapiens	27-32
34826170-7	2022	Melatonin-induced OTUD1 upregulation caused deubiquitnation at the lysine 3 residue of Bim, resulting in its stabilization.	Lysine	67-73	BCL2 like 11	Homo sapiens	87-90
31908356-3	2020	Here, we assess the regulatory role of mouse Dot1l, a histone H3 lysine (K) 79 (H3K79) methyltransferase, in lymphatic formation.	Lysine	65-71	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	45-50
19112497-6	2008	Likewise, lysine-deficient TRAF6 was found to interact with the TAK1-TAB1-TAB2 complex, but surprisingly was also found to be fully competent to activate TAK1, as well as NFkappaB and AP-1 reporters.	Lysine	10-16	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	64-68
19112497-6	2008	Likewise, lysine-deficient TRAF6 was found to interact with the TAK1-TAB1-TAB2 complex, but surprisingly was also found to be fully competent to activate TAK1, as well as NFkappaB and AP-1 reporters.	Lysine	10-16	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	154-158
19112497-7	2008	Furthermore, lysine-deficient TRAF6 rescued IL-1-mediated NFkappaB and MAPK activation, as well as IL-6 elaboration in retrovirally-rescued TRAF6-deficient fibroblasts.	Lysine	13-19	TNF receptor associated factor 6	Homo sapiens	30-35
19112497-7	2008	Furthermore, lysine-deficient TRAF6 rescued IL-1-mediated NFkappaB and MAPK activation, as well as IL-6 elaboration in retrovirally-rescued TRAF6-deficient fibroblasts.	Lysine	13-19	interleukin 1 alpha	Homo sapiens	44-48
19112497-8	2008	Lysine-deficient TRAF6 also rescued RANKL-mediated NFkappaB and MAPK activation, and osteoclastogenesis in retrovirally-rescued TRAF6-deficient bone marrow macrophages.	Lysine	0-6	TNF receptor associated factor 6	Homo sapiens	17-22
19112497-9	2008	While incapable of being ubiquitinated itself, we demonstrate that lysine-deficient TRAF6 remains competent to induce ubiquitination of IKKgamma/NEMO.	Lysine	67-73	TNF receptor associated factor 6	Homo sapiens	84-89
34964862-4	2022	Mutational analysis identified lysine residue 89 in RMDN3 as a site of ubiquitination by MITOL.	Lysine	31-37	membrane associated ring-CH-type finger 5	Homo sapiens	89-94
32447051-6	2020	Targeted chromatin immunoprecipitation (ChIP) revealed that GIPC increases the histone 3 lysine 27 (H3K27) acetylation activating mark and concurrently decreases the H3K27 inhibitory trimethylation (H3K27m3) mark providing an epigenetic correlate to the gene regulation changes.	Lysine	89-95	GIPC PDZ domain containing family member 1	Homo sapiens	60-64
34917889-0	2021	Kinetic Characterization of Human Histone Deacetylase 8 With Medium-Chain Fatty Acyl Lysine.	Lysine	85-91	histone deacetylase 8	Homo sapiens	34-55
34917889-5	2021	HDAC8 activity was analyzed with various peptides where the target lysine is modified with medium-chain fatty acyl group.	Lysine	67-73	histone deacetylase 8	Homo sapiens	0-5
19112497-9	2008	While incapable of being ubiquitinated itself, we demonstrate that lysine-deficient TRAF6 remains competent to induce ubiquitination of IKKgamma/NEMO.	Lysine	67-73	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	136-144
19112497-9	2008	While incapable of being ubiquitinated itself, we demonstrate that lysine-deficient TRAF6 remains competent to induce ubiquitination of IKKgamma/NEMO.	Lysine	67-73	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	145-149
17977840-0	2007	Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.	Lysine	145-151	NAD-dependent histone deacetylase HST3	Saccharomyces cerevisiae S288C	0-4
33189948-0	2020	Synthesis and evaluation of [18F]FP-Lys-GE11 as a new radiolabeled peptide probe for epidermal growth factor receptor (EGFR) imaging.	Lysine	36-39	epidermal growth factor receptor	Mus musculus	85-117
17977840-2	2007	We find that Hst3 has NAD-dependent histone deacetylase activity in vitro and that it functions during S phase to deacetylate the core domain of histone H3 at lysine 56 (H3K56).	Lysine	159-165	NAD-dependent histone deacetylase HST3	Saccharomyces cerevisiae S288C	13-17
17951578-1	2007	Class III histone deacetylases (Sir2 or sirtuins) catalyze the NAD+-dependent conversion of acetyl-lysine residues to nicotinamide, 2"-O-acetyl-ADP-ribose (OAADPr), and deacetylated lysine.	Lysine	99-105	sirtuin 2	Homo sapiens	32-36
34648748-3	2021	We show that, when activated in germ cells, HSF-1 recruits MET-2, the putative histone 3 lysine 9 (H3K9) methyltransferase responsible for repressive H3K9me2 (H3K9 dimethyl) marks in chromatin, and negatively bookmarks the insulin receptor daf-2 and other HSF-1 target genes.	Lysine	89-95	Heat shock transcription factor hsf-1	Caenorhabditis elegans	44-49
33189948-0	2020	Synthesis and evaluation of [18F]FP-Lys-GE11 as a new radiolabeled peptide probe for epidermal growth factor receptor (EGFR) imaging.	Lysine	36-39	epidermal growth factor receptor	Mus musculus	119-123
34856916-3	2021	Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors, and membrane-associated receptors.	Lysine	55-61	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	32-38
34856916-3	2021	Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors, and membrane-associated receptors.	Lysine	89-95	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	32-38
17951578-5	2007	Interestingly, propionyl- and butyryl-lysine peptides were found to bind tighter to Hst2 compared with acetyl-lysine peptide and showed measurable rates of catalysis with Hst2, Sirt1, Sirt2, and Sirt3, suggesting propionyl- and butyryl-lysine proteins may be sirtuin substrates in vivo.	Lysine	38-44	fibroblast growth factor 6	Homo sapiens	84-88
17951578-5	2007	Interestingly, propionyl- and butyryl-lysine peptides were found to bind tighter to Hst2 compared with acetyl-lysine peptide and showed measurable rates of catalysis with Hst2, Sirt1, Sirt2, and Sirt3, suggesting propionyl- and butyryl-lysine proteins may be sirtuin substrates in vivo.	Lysine	38-44	fibroblast growth factor 6	Homo sapiens	171-175
17951578-5	2007	Interestingly, propionyl- and butyryl-lysine peptides were found to bind tighter to Hst2 compared with acetyl-lysine peptide and showed measurable rates of catalysis with Hst2, Sirt1, Sirt2, and Sirt3, suggesting propionyl- and butyryl-lysine proteins may be sirtuin substrates in vivo.	Lysine	38-44	sirtuin 2	Homo sapiens	184-189
31423568-10	2019	CONCLUSIONS AND IMPLICATIONS: Inhibition of lysine acetylation suppresses aldosterone-dependent control over the SGK1-ENaC pathway, but does not perturb post-transcriptional signalling, providing a physiological basis for the anti-hypertensive action of KDAC inhibition seen in vivo.	Lysine	44-50	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	118-122
34478776-6	2021	A region was revealed within the Abeta sequence, in which proteolytic cleavage (Lys-28) and oxidation (Met-35) lead to a loss of their ability to inhibit the interaction of trypsin with alpha2M.	Lysine	80-83	alpha-2-macroglobulin	Homo sapiens	186-193
31515918-1	2019	HLA-B*46:01:08 has one synonymous nucleotide change from HLA-B*46:01:01 at nucleotide 801 (codon 243 Lysine).	Lysine	101-107	major histocompatibility complex, class I, B	Homo sapiens	0-5
34710711-11	2021	Differences in body weight and ADG were observed from d 14 to d 28, resulting in a trending improvement in lysine digestibility on d 14 and carcass quality on d 46 of birds fed AML and AMH in comparison to those fed F (P < 0.05).	Lysine	107-113	anti-Mullerian hormone	Homo sapiens	185-188
18154663-8	2007	These unusual binding properties could be attributed to a different conformation of the binding pocket that allows to accommodate negative charges; moreover, we identified a cluster of solvent exposed Lys residues, which are only found in the EH domain of POB1, and influence binding to both NPF and DPF motifs.	Lysine	201-204	RALBP1 associated Eps domain containing protein 2	Mus musculus	256-260
31515918-1	2019	HLA-B*46:01:08 has one synonymous nucleotide change from HLA-B*46:01:01 at nucleotide 801 (codon 243 Lysine).	Lysine	101-107	major histocompatibility complex, class I, B	Homo sapiens	57-62
31775874-1	2019	BACKGROUND: Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression.	Lysine	32-38	euchromatic histone lysine methyltransferase 1	Homo sapiens	69-76
18075593-4	2007	Here we show that CLOCK also acetylates a non-histone substrate: its own partner, BMAL1, is specifically acetylated on a unique, highly conserved Lys 537 residue.	Lysine	146-149	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	82-87
34755747-3	2021	In recent experiments, lysine-targeting has been envisaged for the irreversible inhibition of the heterodimeric lipid kinase phosphoinositide 3-kinase delta (PI3Kdelta).	Lysine	23-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	158-167
34618427-5	2021	Moreover, the site specifically incorporated lysine benzoylation within native full-length histone proteins revealed distinct dynamics of debenzoylation in the presence of debenzoylase sirtuin 2 (SIRT2).	Lysine	45-51	sirtuin 2	Homo sapiens	185-194
17606808-1	2007	The glutamic acid to lysine mutation at the 22nd amino acid residue (E22K) in the human cardiac myosin regulatory light chain (RLC) gene causes familial hypertrophic cardiomyopathy (FHC) with a phenotype of midventricular obstruction and septal hypertrophy.	Lysine	21-27	low density lipoprotein receptor	Homo sapiens	182-185
34618427-5	2021	Moreover, the site specifically incorporated lysine benzoylation within native full-length histone proteins revealed distinct dynamics of debenzoylation in the presence of debenzoylase sirtuin 2 (SIRT2).	Lysine	45-51	sirtuin 2	Homo sapiens	196-201
31578285-6	2019	We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages.	Lysine	192-195	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	95-102
34796642-0	2022	Charge neutralization of lysine via carbamylation reveals hidden aggregation hot-spots in tau protein flanking regions.	Lysine	25-31	microtubule associated protein tau	Homo sapiens	90-93
17898065-1	2007	We analyzed the levels of acetylated histones and histone H3 dimethylated on lysine 4 (H3K4me2) at the LMP2A promoter (LMP2Ap) of Epstein-Barr virus in well-characterized type I and type III lymphoid cell line pairs and additionally in the nasopharyngeal carcinoma cell line C666-1 by using chromatin immunoprecipitation.	Lysine	77-83	LMP2A	Human gammaherpesvirus 4	103-108
17898065-1	2007	We analyzed the levels of acetylated histones and histone H3 dimethylated on lysine 4 (H3K4me2) at the LMP2A promoter (LMP2Ap) of Epstein-Barr virus in well-characterized type I and type III lymphoid cell line pairs and additionally in the nasopharyngeal carcinoma cell line C666-1 by using chromatin immunoprecipitation.	Lysine	77-83	LMP2A	Human gammaherpesvirus 4	119-125
34796642-2	2022	The longest human tau isoform (2N4R) has 44 lysine residues.	Lysine	44-50	microtubule associated protein tau	Homo sapiens	18-21
31578285-6	2019	We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages.	Lysine	206-209	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	95-102
34796642-4	2022	Carbamylation is one such lysine neutralizing age-related non-enzymatic PTM which can modulate the aggregation propensity of tau.	Lysine	26-32	microtubule associated protein tau	Homo sapiens	125-128
34796642-5	2022	In the present work, we have studied the aggregation potential of lysine-rich regions of tau upon carbamylation which do not aggregate in their native form.	Lysine	66-72	microtubule associated protein tau	Homo sapiens	89-92
31722219-3	2019	More importantly, CCDC84 acetylation oscillates throughout the cell cycle, and the acetylation state of CCDC84 at lysine 31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10.	Lysine	114-120	centrosomal AT-AC splicing factor	Homo sapiens	104-110
34784956-11	2021	TAE226-mediated FAK depletion and SOR-promoted MAPK down-modulation caused a decrease in the nuclear amount of HDAC1/2 and a consequent increase of the histone H3 lysine 27 acetylation, thus counteracting histone H3 lysine 27 trimethylation.	Lysine	163-169	histone deacetylase 1	Mus musculus	111-118
17923702-0	2007	DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.	Lysine	34-40	ATM serine/threonine kinase	Homo sapiens	49-52
17923702-0	2007	DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.	Lysine	34-40	ATM serine/threonine kinase	Homo sapiens	63-66
17923702-3	2007	In this study, systematic mutagenesis of lysine residues was used to identify regulatory ATM acetylation sites.	Lysine	41-47	ATM serine/threonine kinase	Homo sapiens	89-92
17923702-6	2007	Furthermore, lysine 3016 of ATM is a substrate in vitro for the Tip60 histone acetyltransferase.	Lysine	13-19	ATM serine/threonine kinase	Homo sapiens	28-31
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	ATM serine/threonine kinase	Homo sapiens	106-109
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	ATM serine/threonine kinase	Homo sapiens	106-109
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	ATM serine/threonine kinase	Homo sapiens	106-109
17923702-7	2007	Mutation of lysine 3016 does not affect unstimulated ATM kinase activity but does abolish upregulation of ATM"s kinase activity by DNA damage, inhibits the conversion of inactive ATM dimers to active ATM monomers, and prevents the ATM-dependent phosphorylation of the p53 and chk2 proteins.	Lysine	12-18	ATM serine/threonine kinase	Homo sapiens	106-109
34784956-11	2021	TAE226-mediated FAK depletion and SOR-promoted MAPK down-modulation caused a decrease in the nuclear amount of HDAC1/2 and a consequent increase of the histone H3 lysine 27 acetylation, thus counteracting histone H3 lysine 27 trimethylation.	Lysine	216-222	histone deacetylase 1	Mus musculus	111-118
34738714-5	2022	Mechanistically, PELI1 mediated the lysine 48 (Lys48)-linked polyubiquitination and degradation of NF-kappaB-inducing kinase (NIK; also known as MAP3K14), the master kinase of the noncanonical NF-kappaB pathway, thereby inhibiting IR-induced activation of the noncanonical NF-kappaB signaling pathway during radiotherapy.	Lysine	36-42	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	99-124
31521505-1	2019	Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27.	Lysine	136-142	embryonic ectoderm development	Mus musculus	52-55
34738714-5	2022	Mechanistically, PELI1 mediated the lysine 48 (Lys48)-linked polyubiquitination and degradation of NF-kappaB-inducing kinase (NIK; also known as MAP3K14), the master kinase of the noncanonical NF-kappaB pathway, thereby inhibiting IR-induced activation of the noncanonical NF-kappaB signaling pathway during radiotherapy.	Lysine	36-42	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	126-129
34592314-2	2021	SetD7 is a histone methyltransferase enriched in pancreatic islets that mono- and di-methylates histone-3-lysine-4 (H3K4), promoting euchromatin modifications, and also maintains the regulation of key beta-cell function and survival genes.	Lysine	106-112	SET domain containing 7, histone lysine methyltransferase	Rattus norvegicus	0-5
17923702-8	2007	These results are consistent with a model in which acetylation of lysine 3016 in the FATC domain of ATM activates the kinase activity of ATM.	Lysine	66-72	ATM serine/threonine kinase	Homo sapiens	100-103
17923702-8	2007	These results are consistent with a model in which acetylation of lysine 3016 in the FATC domain of ATM activates the kinase activity of ATM.	Lysine	66-72	ATM serine/threonine kinase	Homo sapiens	137-140
17923702-9	2007	The acetylation of ATM on lysine 3016 by Tip60 is therefore a key step linking the detection of DNA damage and the activation of ATM kinase activity.	Lysine	26-32	ATM serine/threonine kinase	Homo sapiens	19-22
17923702-9	2007	The acetylation of ATM on lysine 3016 by Tip60 is therefore a key step linking the detection of DNA damage and the activation of ATM kinase activity.	Lysine	26-32	ATM serine/threonine kinase	Homo sapiens	129-132
31505256-2	2019	Using a model of chronic constriction injury (CCI) of the sciatic nerve, this study characterized the role of SET domain containing lysine methyltransferase 7 (SETD7) which monomethylates histone H3 lysine 4 (H3K4me1), a marker for active gene transcription.	Lysine	132-138	SET domain containing 7, histone lysine methyltransferase	Rattus norvegicus	160-165
17980595-3	2007	Plant polycomb proteins FIE, VRN2, CLF, and SWN, together with VIN3, form a complex that adds histone H3 lysine 27 methylation at FLC in vernalized plants.	Lysine	105-111	VEFS-Box of polycomb protein	Arabidopsis thaliana	29-33
34726593-8	2021	Additionally, the lysine residues located at the cytoplasmic tail of l-selectin were required for the K5-mediated downregulation of l-selectin.	Lysine	18-24	selectin L	Homo sapiens	69-79
34726593-8	2021	Additionally, the lysine residues located at the cytoplasmic tail of l-selectin were required for the K5-mediated downregulation of l-selectin.	Lysine	18-24	selectin L	Homo sapiens	132-142
34859145-1	2021	We reported that histone H3 lysine (K) 4 methyltransferase, KMT2D, serves as a potent tumor-suppressor in melanoma, which was identified via in vivo epigenome-focused RNA interference (RNAi) screen.	Lysine	28-34	lysine methyltransferase 2D	Homo sapiens	60-65
31125684-1	2019	Glutaric acidemia type I (GA I) is an inherited neurometabolic disease caused by deficient activity of the mitochondrial enzyme glutaryl-CoA dehydrogenase (GCDH), resulting in predominant accumulation of glutaric and 3-hydroxyglutaric acids derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	254-260	glutaryl-Coenzyme A dehydrogenase	Mus musculus	128-154
34694864-0	2021	GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.	Lysine	113-119	lysine methyltransferase 2A	Homo sapiens	31-36
17910072-9	2007	The 9qSTDS is caused by haplo-insufficiency of EHMT1, a gene whose protein product (Eu-HMTase1) is a histone H3 Lys 9 (H3-K9) methyltransferase.	Lysine	112-115	euchromatic histone lysine methyltransferase 1	Homo sapiens	47-52
17910072-9	2007	The 9qSTDS is caused by haplo-insufficiency of EHMT1, a gene whose protein product (Eu-HMTase1) is a histone H3 Lys 9 (H3-K9) methyltransferase.	Lysine	112-115	euchromatic histone lysine methyltransferase 1	Homo sapiens	84-94
31125684-1	2019	Glutaric acidemia type I (GA I) is an inherited neurometabolic disease caused by deficient activity of the mitochondrial enzyme glutaryl-CoA dehydrogenase (GCDH), resulting in predominant accumulation of glutaric and 3-hydroxyglutaric acids derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	254-260	glutaryl-Coenzyme A dehydrogenase	Mus musculus	156-160
31125684-1	2019	Glutaric acidemia type I (GA I) is an inherited neurometabolic disease caused by deficient activity of the mitochondrial enzyme glutaryl-CoA dehydrogenase (GCDH), resulting in predominant accumulation of glutaric and 3-hydroxyglutaric acids derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	262-265	glutaryl-Coenzyme A dehydrogenase	Mus musculus	128-154
31125684-1	2019	Glutaric acidemia type I (GA I) is an inherited neurometabolic disease caused by deficient activity of the mitochondrial enzyme glutaryl-CoA dehydrogenase (GCDH), resulting in predominant accumulation of glutaric and 3-hydroxyglutaric acids derived from lysine (Lys), hydroxylysine, and tryptophan catabolism.	Lysine	262-265	glutaryl-Coenzyme A dehydrogenase	Mus musculus	156-160
17996705-3	2007	Here we show that the acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains.	Lysine	41-47	H3 histone pseudogene 16	Homo sapiens	118-121
17996705-4	2007	UV irradiation of cells diacetylates p53 at lysines 373 and 382, which in turn recruits TAF1 to a distal p53-binding site on the p21 promoter prior to looping to the core promoter.	Lysine	44-51	H3 histone pseudogene 16	Homo sapiens	129-132
34718330-2	2021	Lysine acetyltransferase family (KATs) can regulate the nuclear transcription or cytoplasmic activation of cGAS through different mechanisms.	Lysine	0-6	cyclic GMP-AMP synthase	Homo sapiens	107-111
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	phosphoenolpyruvate carboxykinase 1	Homo sapiens	286-290
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	150-153	phosphoenolpyruvate carboxykinase 1	Homo sapiens	176-180
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	150-153	phosphoenolpyruvate carboxykinase 1	Homo sapiens	182-186
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	150-153	phosphoenolpyruvate carboxykinase 1	Homo sapiens	286-290
31596631-6	2019	Interestingly, we found that ELF blocked p65 translocation in LPS-stimulated Raw 264.7 cells by attenuating acetylation at lysine residue 310 of p65.	Lysine	123-129	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	41-44
34706239-6	2021	Mechanistically, Peli1 conjugates K63 ubiquitin chain to lysine 55 of the inflammasome adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which in turn facilitates ASC/NLRP3 interaction and ASC oligomerization, thereby contributing to inflammasome activation.	Lysine	57-63	pellino 1	Mus musculus	17-22
34706239-6	2021	Mechanistically, Peli1 conjugates K63 ubiquitin chain to lysine 55 of the inflammasome adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which in turn facilitates ASC/NLRP3 interaction and ASC oligomerization, thereby contributing to inflammasome activation.	Lysine	57-63	NLR family, pyrin domain containing 3	Mus musculus	212-217
17922839-9	2007	Because conservative Lys residues located in the beta5-beta7 loop and in the beta7 strand appear to play an important role in the structure and properties of HSP22, mutations in this part of the small heat shock protein molecule might have a deleterious effect and often correlate with the development of different congenital diseases.	Lysine	21-24	adaptor related protein complex 5 subunit beta 1	Homo sapiens	49-54
31596631-6	2019	Interestingly, we found that ELF blocked p65 translocation in LPS-stimulated Raw 264.7 cells by attenuating acetylation at lysine residue 310 of p65.	Lysine	123-129	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	145-148
31121257-5	2019	Lys also provoked a reduction of NeuN and synaptophysin, as well as an increase of astrocytic GFAP, in the striatum of Gcdh-/- mice, indicating neuronal loss and astrocyte reactivity.	Lysine	0-3	synaptophysin	Mus musculus	42-55
17727612-5	2007	CRR1 is homologous to dihydrodipicolinate reductase (DHPR), which functions in a lysine biosynthesis pathway.	Lysine	81-87	Dihydrodipicolinate reductase, bacterial/plant	Arabidopsis thaliana	0-4
34697420-6	2021	Meanwhile, serum corticosterone, the expression and histone 3 lysine 14 acetylation (H3K14ac) of testicular insulin-like growth factor 1 (IGF1) were significantly decreased.	Lysine	62-68	insulin-like growth factor 1	Rattus norvegicus	108-136
34697420-6	2021	Meanwhile, serum corticosterone, the expression and histone 3 lysine 14 acetylation (H3K14ac) of testicular insulin-like growth factor 1 (IGF1) were significantly decreased.	Lysine	62-68	insulin-like growth factor 1	Rattus norvegicus	138-142
31121257-5	2019	Lys also provoked a reduction of NeuN and synaptophysin, as well as an increase of astrocytic GFAP, in the striatum of Gcdh-/- mice, indicating neuronal loss and astrocyte reactivity.	Lysine	0-3	glial fibrillary acidic protein	Mus musculus	94-98
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	120-123	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	47-51
34722538-5	2021	Here we demonstrate that preventing Drp1 SUMOylation by mutating its SUMO target lysines enhances the Drp1-Bcl-x L interaction in vivo and in vitro.	Lysine	81-88	dynamin 1 like	Homo sapiens	36-40
34722538-5	2021	Here we demonstrate that preventing Drp1 SUMOylation by mutating its SUMO target lysines enhances the Drp1-Bcl-x L interaction in vivo and in vitro.	Lysine	81-88	dynamin 1 like	Homo sapiens	102-106
17877703-6	2007	Specific HATs acetylate histone H4K5 (HAM1, HAM2), H4K12 (HAG2), and H3K14 (HAG1), suggesting that acetylation of these lysines may have special regulatory significance.	Lysine	120-127	histone acetyltransferase of the MYST family 2	Arabidopsis thaliana	44-48
17877703-6	2007	Specific HATs acetylate histone H4K5 (HAM1, HAM2), H4K12 (HAG2), and H3K14 (HAG1), suggesting that acetylation of these lysines may have special regulatory significance.	Lysine	120-127	histone acetyltransferase of the GNAT family 2	Arabidopsis thaliana	58-62
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	120-123	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	105-109
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	47-51
34650128-4	2021	Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis revealed that DLEU1 knockdown induced significant changes in the levels of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac) in OSCC cells.	Lysine	147-153	deleted in lymphocytic leukemia 1	Homo sapiens	75-80
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	105-109
31366726-7	2019	We further observed that the ankyrin repeat in MIB2 interacts with the third CAP domain in CYLD and that MIB2 catalyzes Lys-48-linked polyubiquitination of CYLD at Lys-338 and Lys-530.	Lysine	164-167	mindbomb E3 ubiquitin protein ligase 2	Mus musculus	47-51
34642466-0	2022	Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage.	Lysine	64-70	transformation related protein 53, pseudogene	Mus musculus	14-17
34642466-4	2022	Using mass spectrometric analysis, we identify a previously unknown PTM of p53, namely, succinylation of p53 at Lysine 120 (K120).	Lysine	112-118	transformation related protein 53, pseudogene	Mus musculus	75-78
17962409-0	2007	Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair.	Lysine	68-74	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	0-6
17962409-7	2007	These constraints are explained by a proposed mechanism for GTP-induced dissociation of Galpha from Gbetagamma where an Arg-Trp pair senses the presence of bound GTP leading to conformational retraction of a nearby lysine and to disruption of an aromatic cluster.	Lysine	215-221	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	88-94
34642466-4	2022	Using mass spectrometric analysis, we identify a previously unknown PTM of p53, namely, succinylation of p53 at Lysine 120 (K120).	Lysine	112-118	transformation related protein 53, pseudogene	Mus musculus	105-108
31420217-5	2019	Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1beta production.	Lysine	115-121	interleukin 1 alpha	Homo sapiens	144-152
34635784-4	2022	Mechanistically, FZR1 insufficiency inhibits the ubiquitination of RUNX1 protein at lysine 125, leading to the accumulation of RUNX1 protein, which disturbs the quiescence of HSCs in SAA patients.	Lysine	84-90	fizzy and cell division cycle 20 related 1	Homo sapiens	17-21
31616951-5	2019	MORC2, in turn, stabilizes PARP1 through enhancing acetyltransferase NAT10-mediated acetylation of PARP1 at lysine 949, which blocks its ubiquitination at the same residue and subsequent degradation by E3 ubiquitin ligase CHFR.	Lysine	108-114	checkpoint with forkhead and ring finger domains	Homo sapiens	222-226
34635784-4	2022	Mechanistically, FZR1 insufficiency inhibits the ubiquitination of RUNX1 protein at lysine 125, leading to the accumulation of RUNX1 protein, which disturbs the quiescence of HSCs in SAA patients.	Lysine	84-90	RUNX family transcription factor 1	Homo sapiens	67-72
34635784-4	2022	Mechanistically, FZR1 insufficiency inhibits the ubiquitination of RUNX1 protein at lysine 125, leading to the accumulation of RUNX1 protein, which disturbs the quiescence of HSCs in SAA patients.	Lysine	84-90	RUNX family transcription factor 1	Homo sapiens	127-132
17936707-4	2007	LXR acetylation is evident at a single conserved lysine (K432 in LXRalpha and K433 in LXRbeta) adjacent to the ligand-regulated activation domain AF2.	Lysine	49-55	nuclear receptor subfamily 1 group H member 2	Homo sapiens	86-93
17669357-3	2007	Flanking Lys residues mimic the natural setting of this peptide in DGKepsilon, while facilitating peptide synthesis and characterization.	Lysine	9-12	diacylglycerol kinase epsilon	Homo sapiens	67-77
17917251-0	2007	LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.	Lysine	46-49	LIF interleukin 6 family cytokine	Homo sapiens	0-3
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	89-92	LIF interleukin 6 family cytokine	Homo sapiens	141-144
34343833-1	2021	The SET domain containing lysine-specific methyltransferase, Set7/9, covalently attaches methyl moieties to a variety of histone and non-histone substrates.	Lysine	26-32	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	61-67
31533203-10	2019	Taken together, our studies suggest that acrolein modification of apoE3 at lysine residues leads to increase in net negative charge, and as a consequence, results in clearance by LOX1 and SRB1 on endothelial cells.	Lysine	75-81	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	179-183
34251718-9	2021	MLL recruits p300/CBP through its transcriptional activation domain, which acetylates histone H3 at lysines 9, 18, and 27.	Lysine	100-107	lysine methyltransferase 2A	Homo sapiens	0-3
17917251-3	2007	In the present study, we created an acetyl-specific antibody against STAT3 acetylated at Lys-685, and found that leukemia inhibitory factor (LIF) or interleukin (IL)-6 induced acetylation of STAT3 at Lys-685 in 293T and Hep3B cells.	Lysine	200-203	LIF interleukin 6 family cytokine	Homo sapiens	141-144
17917251-5	2007	Taken together, our findings demonstrate that endogenous STAT3 is acetylated at Lys-685 by LIF or IL-6 through PI3K/Akt activation.	Lysine	80-83	LIF interleukin 6 family cytokine	Homo sapiens	91-94
17936034-0	2007	A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.	Lysine	56-62	recombination activating 2	Homo sapiens	23-28
31346037-5	2019	Using co-immunoprecipitation, MS, and methylation assays, we demonstrate that Mettl21c trimethylates heat shock protein 8 (Hspa8) at Lys-561 to enhance its stability.	Lysine	133-136	methyltransferase like 21C	Mus musculus	78-86
17936034-3	2007	We have found that RAG-2 bound specifically to histone H3 and that this binding was absolutely dependent on dimethylation or trimethylation at lysine 4 (H3K4me2 or H3K4me3).	Lysine	143-149	recombination activating 2	Homo sapiens	19-24
34661519-4	2021	Site-directed mutagenesis revealed that three lysine residues (K91, K95 and K140) on the HBx protein, which are well conserved among all the HBV genotypes, are involved in acceptance of ISGylation.	Lysine	46-52	X protein	Hepatitis B virus	89-92
31511540-3	2019	Here, we show that DNA damage-induced SMG7-p53 binding requires phosphorylated Ser15 on p53, and that substitution of the conserved lysine residue K66 in the SMG7 14-3-3-like domain with the glutamic acid (E) abolishes interactions with its client proteins p53 and UPF1.	Lysine	132-138	UPF1 RNA helicase and ATPase	Homo sapiens	265-269
34429771-6	2021	In addition, SIRT2 is also known to possess lysine fatty deacylation activity.	Lysine	44-50	sirtuin 2	Homo sapiens	13-18
17415778-4	2007	We find that in noncancerous prostate cells (RWPE-1 and PWR-1E) GSTP1 is constitutively expressed, not methylated, highly accessible, bound by transcription factors and associated with histones with activating modifications (histone H3 methylated at lysine 4 and acetylated histones H3 and H4).	Lysine	250-256	glutathione S-transferase pi 1	Homo sapiens	64-69
31447373-1	2019	Rhodopsins, the major light-detecting molecules of animal visual systems [1], consist of opsin apoproteins that covalently bind a retinal chromophore with a conserved lysine residue [1, 2].	Lysine	167-173	neither inactivation nor afterpotential E	Drosophila melanogaster	4-9
17640876-7	2007	Fab fragments of binding-neutralizing antibody H16.56E that recognize an epitope directly adjacent to lysine residues strongly reduced HS-mediated cell binding, further corroborating our findings.	Lysine	102-108	FA complementation group B	Homo sapiens	0-3
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Lysine	14-20	insulin-like growth factor 1	Rattus norvegicus	89-93
34551411-1	2022	Mixed lineage leukemia (MLL) T10 is a relatively rare partner for the KMT2A lysine (K)-specific methyltransferase 2A gene.	Lysine	76-82	lysine methyltransferase 2A	Homo sapiens	24-27
17652096-8	2007	Deletion of Set1, the Lys(4) methyltransferase, was associated with the linked disappearance of both Lys(4) methylation and Lys(14) and Lys(18) or Lys(23) acetylation on H3.	Lysine	22-25	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	12-16
31238259-7	2019	L-Lysine significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor-alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts, and it increased the reduced glutathione levels and the glutathione peroxidase, superoxide dismutase, and catalase activities.	Lysine	0-8	myeloperoxidase	Rattus norvegicus	206-209
34479991-4	2021	This decrease in SETDB2 upon coronavirus infection results in a decrease of the repressive trimethylation of histone 3 lysine 9 (H3K9me3) at NFkB binding sites on inflammatory gene promoters, effectively increasing inflammation.	Lysine	119-125	SET domain bifurcated histone lysine methyltransferase 2	Homo sapiens	17-23
17652096-8	2007	Deletion of Set1, the Lys(4) methyltransferase, was associated with the linked disappearance of both Lys(4) methylation and Lys(14) and Lys(18) or Lys(23) acetylation on H3.	Lysine	101-104	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	12-16
30837697-0	2019	Atypical COL3A1 variants (glutamic acid to lysine) cause vascular Ehlers-Danlos syndrome with a consistent phenotype of tissue fragility and skin hyperextensibility.	Lysine	43-49	collagen type III alpha 1 chain	Homo sapiens	9-15
17652096-8	2007	Deletion of Set1, the Lys(4) methyltransferase, was associated with the linked disappearance of both Lys(4) methylation and Lys(14) and Lys(18) or Lys(23) acetylation on H3.	Lysine	101-104	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	12-16
17652096-8	2007	Deletion of Set1, the Lys(4) methyltransferase, was associated with the linked disappearance of both Lys(4) methylation and Lys(14) and Lys(18) or Lys(23) acetylation on H3.	Lysine	101-104	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	12-16
17646165-3	2007	We demonstrated that Ubc9, the E2 component of the sumoylation machinery, specifically interacts with the N-terminal domain of GCMa and promotes GCMa sumoylation on lysine 156.	Lysine	165-171	glial cells missing	Drosophila melanogaster	145-149
34382399-10	2021	OMG ameliorated the acetylation of p53 at lysine 382 (K382) and subsequent activation of p21 via inhibition of PAI-1.	Lysine	42-48	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	35-38
34545670-4	2022	By replacing neutral threonine with positively charged lysine at the 232 sites, the T232K and K238 rings of this engineered T232K AeL nanopore corporately work together to enhance electrostatic trapping of the acetylated and phosphorylated Tau peptides.	Lysine	55-61	microtubule associated protein tau	Homo sapiens	240-243
30837697-3	2019	We describe the phenotype of the largest series of vEDS patients with glutamic acid to lysine substitutions (Glu>Lys) in COL3A1, which were all previously considered to be variants of unknown significance.	Lysine	87-93	collagen type III alpha 1 chain	Homo sapiens	121-127
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	RAP1A, member of RAS oncogene family	Homo sapiens	35-39
30837697-3	2019	We describe the phenotype of the largest series of vEDS patients with glutamic acid to lysine substitutions (Glu>Lys) in COL3A1, which were all previously considered to be variants of unknown significance.	Lysine	113-116	collagen type III alpha 1 chain	Homo sapiens	121-127
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	RAP1A, member of RAS oncogene family	Homo sapiens	238-242
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	92-95	LDL receptor related protein associated protein 1	Homo sapiens	288-291
30837697-4	2019	METHODS: Clinical and molecular data for seven families with three different Glu>Lys substitutions in COL3A1 were analyzed.	Lysine	81-84	collagen type III alpha 1 chain	Homo sapiens	102-108
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	RAP1A, member of RAS oncogene family	Homo sapiens	35-39
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	RAP1A, member of RAS oncogene family	Homo sapiens	238-242
18690035-6	2007	However, homology modelling and molecular dynamics simulations demonstrate that the TM1 lysine in Kir4.1 is capable of H-bonding at the helix-bundle crossing.	Lysine	88-94	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	98-104
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	142-145	LDL receptor related protein associated protein 1	Homo sapiens	288-291
30837697-8	2019	The three different Glu>Lys variants point toward a new variant type in COL3A1 causative of vEDS, which has consistent clinical features.	Lysine	24-27	collagen type III alpha 1 chain	Homo sapiens	72-78
17627840-8	2007	Moreover, we examined the acetylation of lysine residues in HMGA1a and HMGA1b isolated from PC-3 human prostate cancer cells.	Lysine	41-47	high mobility group AT-hook 1	Homo sapiens	60-66
31218831-12	2019	KDM2B is acetylated at lysine 758 by Tip60 in human osteosarcoma cells.	Lysine	23-29	lysine demethylase 2B	Homo sapiens	0-5
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	43-49	high mobility group AT-hook 1	Homo sapiens	123-129
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	94-97	high mobility group AT-hook 1	Homo sapiens	123-129
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	102-105	high mobility group AT-hook 1	Homo sapiens	123-129
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	102-105	high mobility group AT-hook 1	Homo sapiens	123-129
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	102-105	high mobility group AT-hook 1	Homo sapiens	123-129
17627840-9	2007	Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73.	Lysine	102-105	high mobility group AT-hook 1	Homo sapiens	123-129
34518519-13	2021	The deacetylation of PDHE1alpha by SIRT3 at lysine 385 plays a key role in metabolic reprogramming associated with renal fibrosis.	Lysine	44-50	sirtuin 3	Mus musculus	35-40
34512175-4	2021	Three lysine-free EGF variants (RR, RS, and SR) were designed, where two endogenous lysine residues were replaced with either arginine (R) or serine (S).	Lysine	6-12	epidermal growth factor	Homo sapiens	18-21
31202458-8	2019	ChIP-qPCR showed that DLX3 knockdown promoted DKK4 expression by decreasing the enrichment of histone H3 lysine 27 trimethylation (H3K27me3) in the promotor region of DKK4.	Lysine	105-111	dickkopf WNT signaling pathway inhibitor 4	Homo sapiens	46-50
34246782-4	2021	Lysine-specific demethylase 1 (LSD1), binding to 3" domain of HOTAIR, specifically removes mono- and di-methyl marks from H3 lysine 4 (H3K4) and plays key roles during carcinogenesis.	Lysine	125-131	HOX transcript antisense RNA	Homo sapiens	62-68
17702576-2	2007	NEMO was recently found to contain a region that preferentially binds Lys (K)63-linked but not K48-linked polyubiquitin (polyUb) chains, and the ability of NEMO to bind to K63-linked polyUb RIP (receptor-interacting protein) is necessary for efficient tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.	Lysine	70-73	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	0-4
31202458-8	2019	ChIP-qPCR showed that DLX3 knockdown promoted DKK4 expression by decreasing the enrichment of histone H3 lysine 27 trimethylation (H3K27me3) in the promotor region of DKK4.	Lysine	105-111	dickkopf WNT signaling pathway inhibitor 4	Homo sapiens	167-171
34332225-9	2021	Optimum digestible Ile to Lys ratios for Exp 1 were determined to range from 0.640 to 0.725 for growth from 1.0 to 2.5 kg BW (P <= 0.001) and breast meat characteristics.	Lysine	26-29	exportin 1	Homo sapiens	41-46
31271281-1	2019	Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the side chain of acetylated lysine residues in cytoplasmic proteins such as alpha-tubulin and HSP90.	Lysine	112-118	heat shock protein 90 alpha family class A member 1	Homo sapiens	178-183
34485714-2	2021	In this study, we found KLF4 can bind specific site in the promoter of TRIM29 to transactivate its transcription, and sumoylation modification on 278 lysine site was not essential for KLF4 to transactivate TRIM29 transcription.	Lysine	150-156	tripartite motif containing 29	Homo sapiens	71-77
17567584-5	2007	Glycation of vimentin was predominantly detected at lysine residues located at the linker regions using nanoLC-ESI-MS/MS.	Lysine	52-58	vimentin	Homo sapiens	13-21
31208706-5	2019	Interestingly, the addition of 6 lysine residues to the N-terminus of ApoEp (6KApoEp) directly inhibited apoE binding to N-terminal APP and markedly limited apoE- and ApoEp-mediated Abeta generation, presumably through decreasing APP cellular membrane trafficking and p44/42 mitogen-activated protein kinase phosphorylation.	Lysine	33-39	amyloid beta (A4) precursor protein	Mus musculus	182-187
17219431-6	2007	mK1 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Lysine	68-71	keratin 1	Mus musculus	0-3
34406978-10	2021	Inhibition of circRHOT1 reduced the enrichment of transcription active marker histone H3 lysine 27 acetylation (H3K27ac) and RNA polymerase II on the promoter of c-MYC.	Lysine	89-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	162-167
17456799-1	2007	Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins.	Lysine	179-185	sirtuin 2	Homo sapiens	12-16
31368599-3	2019	MITOL promotes K63-linked chain ubiquitination of IRE1alpha at lysine 481 (K481), thereby preventing hyper-oligomerization of IRE1alpha and regulated IRE1alpha-dependent decay (RIDD).	Lysine	63-69	membrane associated ring-CH-type finger 5	Mus musculus	0-5
17456799-1	2007	Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins.	Lysine	179-185	sirtuin 2	Homo sapiens	18-48
34618105-4	2021	Here, we show that H3.3 upregulates FLC expression and promotes active histone modifications histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at the FLC locus.	Lysine	104-110	Histone superfamily protein	Arabidopsis thaliana	19-23
34618105-4	2021	Here, we show that H3.3 upregulates FLC expression and promotes active histone modifications histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at the FLC locus.	Lysine	153-159	Histone superfamily protein	Arabidopsis thaliana	19-23
31340933-5	2019	Two functional copies of the MOZ (KAT6A, MYST3) gene, encoding a MYST family lysine acetyltransferase chromatin regulator, are essential for human craniofacial development, but the molecular role of MOZ in this context is unclear.	Lysine	77-83	lysine acetyltransferase 6A	Homo sapiens	29-32
34147559-1	2021	The protein lysine methyltransferase, SMYD2 is involved in diverse cellular events by regulating protein functions through lysine methylation.	Lysine	12-18	SET and MYND domain containing 2	Homo sapiens	38-43
34147559-1	2021	The protein lysine methyltransferase, SMYD2 is involved in diverse cellular events by regulating protein functions through lysine methylation.	Lysine	123-129	SET and MYND domain containing 2	Homo sapiens	38-43
34321663-2	2021	Non-homologous end joining relies on 53BP1 binding directly to ubiquitinated lysine 15 on H2A-type histones (H2AK15ub)4,5 (which is an RNF168-dependent modification6), but how RNF168 promotes BRCA1 recruitment and function remains unclear.	Lysine	77-83	tumor protein p53 binding protein 1	Homo sapiens	37-42
17540775-9	2007	Residues Arg(76) and Lys(80) in PAI-1 were key elements mediating binding of nucleic acids to PAI-1.	Lysine	21-24	serpin family E member 1	Homo sapiens	32-37
17540775-9	2007	Residues Arg(76) and Lys(80) in PAI-1 were key elements mediating binding of nucleic acids to PAI-1.	Lysine	21-24	serpin family E member 1	Homo sapiens	94-99
17517377-6	2007	Further substitution of Lys(2) with Nle slightly improved the potency of the tetrapeptide, which selectively activates FPRL1 over FPR.	Lysine	24-27	formyl peptide receptor 2	Homo sapiens	119-124
17548045-4	2007	The CD23-based substrate, Dabcyl-His-Gly-Asp-Gln-Met-Ala-Gln-Lys-Ser-Lys(Fam)-NH2, is more selective, being hydrolyzed efficiently only by ADAM8 and ADAM10.	Lysine	61-64	ADAM metallopeptidase domain 8	Homo sapiens	139-144
34089864-12	2021	Specifically, mass spectrometry analysis identified lysine K889 as the acetylation site of SIRT1, which regulates PERK.	Lysine	52-58	sirtuin 1	Mus musculus	91-96
31340933-5	2019	Two functional copies of the MOZ (KAT6A, MYST3) gene, encoding a MYST family lysine acetyltransferase chromatin regulator, are essential for human craniofacial development, but the molecular role of MOZ in this context is unclear.	Lysine	77-83	lysine acetyltransferase 6A	Homo sapiens	34-39
34089864-12	2021	Specifically, mass spectrometry analysis identified lysine K889 as the acetylation site of SIRT1, which regulates PERK.	Lysine	52-58	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	114-118
17586499-4	2007	Site-specific mutagenesis reveals that the conserved lysine residues of Mth1 and Std1 might serve as attachment sites for ubiquitin, and that the potential casein kinase (Yck1/2) sites of serine phosphorylation might control their ubiquitination.	Lysine	53-59	Mth1p	Saccharomyces cerevisiae S288C	72-76
31340933-5	2019	Two functional copies of the MOZ (KAT6A, MYST3) gene, encoding a MYST family lysine acetyltransferase chromatin regulator, are essential for human craniofacial development, but the molecular role of MOZ in this context is unclear.	Lysine	77-83	lysine acetyltransferase 6A	Homo sapiens	41-46
31340933-9	2019	MOZ occupied the Dlx5 locus and was required for normal levels of histone H3 lysine 9 acetylation.	Lysine	77-83	K(lysine) acetyltransferase 6A	Mus musculus	0-3
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	66-74	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	16-20
17586499-4	2007	Site-specific mutagenesis reveals that the conserved lysine residues of Mth1 and Std1 might serve as attachment sites for ubiquitin, and that the potential casein kinase (Yck1/2) sites of serine phosphorylation might control their ubiquitination.	Lysine	53-59	Std1p	Saccharomyces cerevisiae S288C	81-85
34361714-6	2021	In addition, hydrogen bonding occurred between hypericin and alpha-glucosidase amino acid residues Lys-156, Ser-157, Gly-160, Ser-240, His-280, Asp-242, and Asp-307.	Lysine	99-102	sucrase-isomaltase	Homo sapiens	61-78
34219457-0	2021	Discovery of a Fluorogenic Probe for In Situ Pyruvate Kinase M2 Isoform (PKM2) Labeling through Chemoselective SNAr with a Binding Site Lysine Residue.	Lysine	136-142	pyruvate kinase M1/2	Homo sapiens	73-77
17555521-6	2007	AMI1 possesses all conserved amino-acid residues of the Ser-cisSer-Lys triad, but lacks the CX(3)C motif and therefore the Cys-cisSer-Lys catalytic site.	Lysine	67-70	amidase 1	Arabidopsis thaliana	0-4
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	66-74	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	17-20
17555521-6	2007	AMI1 possesses all conserved amino-acid residues of the Ser-cisSer-Lys triad, but lacks the CX(3)C motif and therefore the Cys-cisSer-Lys catalytic site.	Lysine	134-137	amidase 1	Arabidopsis thaliana	0-4
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	76-79	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	16-20
34273022-1	2022	Hypusine (Nepsilon-(4-amino-2-hydroxybutyl)lysine) is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A).	Lysine	70-76	eukaryotic translation initiation factor 5A	Homo sapiens	120-151
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	76-79	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	17-20
34273022-1	2022	Hypusine (Nepsilon-(4-amino-2-hydroxybutyl)lysine) is a derivative of lysine that is formed post-translationally in the eukaryotic initiation factor 5A (eIF5A).	Lysine	70-76	eukaryotic translation initiation factor 5A	Homo sapiens	153-158
31028716-9	2019	Repeated measures ANOVA revealed statistically significant differences between the groups (P = 0.008) with respect to plasma Lys concentration which increased by about 8% after a 4-week hArg supplementation.	Lysine	125-128	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	186-190
34273022-3	2022	Synthesis of hypusine involves two enzymatic steps: first, deoxyhypusine synthase (DHPS) cleaves the 4-aminobutyl moiety of spermidine and transfers it to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form an intermediate, deoxyhypusine (Nepsilon-(4-aminobutyl)lysine).	Lysine	193-199	eukaryotic translation initiation factor 5A	Homo sapiens	215-220
17559584-2	2007	This allele is identical to the HLA-B*3308 allele except for one point mutation in exon 2 at codon 66 (AAA--&gt;AAT), resulting in an amino acid change from lysine (K) to asparagine (N).	Lysine	157-163	major histocompatibility complex, class I, B	Homo sapiens	32-37
31028716-11	2019	Our results suggest that Lys is a metabolite of hArg produced by the hydrolytic activity of arginase.	Lysine	25-28	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	48-52
31100600-2	2019	Here we propose a novel strategy to detect OSCS from heparin solution based on conical nanopore functionalized with poly-L-lysine deposition to ensure its re-usability.	Lysine	116-129	APC membrane recruitment protein 1	Homo sapiens	43-47
17477906-3	2007	A mutant p21(Cip1) in which all six lysines were changed to arginines was protected against H(2)O(2) treatment.	Lysine	36-43	H3 histone pseudogene 16	Homo sapiens	9-12
34156061-4	2021	Such exosites have been found in a few caspases, notably caspase-7 that has a lysine patch (K38KKK) that binds RNA which acts as a bridge to RNA-binding proteins favoring proximity between the peptidase and its substrates resulting in swifter cleavage.	Lysine	78-84	caspase 7	Homo sapiens	57-66
34373735-3	2021	The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L.	Lysine	72-78	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	Mus musculus	18-21
17548821-5	2007	Structure-guided alanine mutagenesis of R5-6 revealed that two Lys residues (Lys-2360 and Lys-2467) constitute a central binding site for the low-density lipoprotein receptor class A module in the receptor, indicating a strong similarity to the ligand recognition mode shared among the endocytic lipoprotein receptors.	Lysine	63-66	low density lipoprotein receptor	Homo sapiens	142-174
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	72-75	mitochondrial antiviral signaling protein	Homo sapiens	64-68
17548821-5	2007	Structure-guided alanine mutagenesis of R5-6 revealed that two Lys residues (Lys-2360 and Lys-2467) constitute a central binding site for the low-density lipoprotein receptor class A module in the receptor, indicating a strong similarity to the ligand recognition mode shared among the endocytic lipoprotein receptors.	Lysine	77-80	low density lipoprotein receptor	Homo sapiens	142-174
17548821-5	2007	Structure-guided alanine mutagenesis of R5-6 revealed that two Lys residues (Lys-2360 and Lys-2467) constitute a central binding site for the low-density lipoprotein receptor class A module in the receptor, indicating a strong similarity to the ligand recognition mode shared among the endocytic lipoprotein receptors.	Lysine	77-80	low density lipoprotein receptor	Homo sapiens	142-174
34373735-3	2021	The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L.	Lysine	72-78	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	108-113
34356841-9	2021	Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310.	Lysine	264-270	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	245-248
34356841-9	2021	Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310.	Lysine	272-275	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	245-248
34356841-10	2021	Deacetylation of that Lys residue is dependent on the activity of SIRT1, which was found to be increased by (S)-(+)-carvone, while its protein levels were unaffected.	Lysine	22-25	sirtuin 1	Mus musculus	66-71
17449468-5	2007	The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively.	Lysine	61-64	TNF receptor associated factor 6	Homo sapiens	165-170
31304625-6	2019	Specifically, RNF34 initiates the K63- to K27-linked ubiquitination transition on MAVS primarily at Lys 311, which facilitates the autophagic degradation of MAVS upon RIG-I stimulation.	Lysine	100-103	mitochondrial antiviral signaling protein	Homo sapiens	82-86
31304625-6	2019	Specifically, RNF34 initiates the K63- to K27-linked ubiquitination transition on MAVS primarily at Lys 311, which facilitates the autophagic degradation of MAVS upon RIG-I stimulation.	Lysine	100-103	mitochondrial antiviral signaling protein	Homo sapiens	157-161
31294688-4	2019	During the activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcriptional activator BMAL1 leading to recruitment of BRD4 and the pause release factor P-TEFb, followed by productive elongation of circadian transcripts.	Lysine	56-62	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	128-133
17449468-5	2007	The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively.	Lysine	61-64	interleukin 1 alpha	Homo sapiens	228-232
33824966-11	2021	Combined activin/GnRH treatment elevated levels of the active transcriptional histone marker, histone 3 lysine 27 acetylation at the enhancer.	Lysine	104-110	gonadotropin releasing hormone 1	Mus musculus	17-21
34135062-7	2021	Mechanistically, USP19 removed the K63-linked ubiquitin chain from RORgammat lysine 313, which is essential for recruiting the coactivator SRC3.	Lysine	77-83	nuclear receptor coactivator 3	Homo sapiens	139-143
17556064-6	2007	In drinkers, the XRCC1 Gln/Gln genotype was significantly protective (OR = 0.06, 95% CI = 0.007-0.605, P = 0.03), whereas ERCC2 (Lys/Gln-Gln/Gln) was marginally associated with increased risk (OR = 2.1, 95% CI = 0.46-9.44).	Lysine	129-132	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	122-127
31294688-4	2019	During the activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcriptional activator BMAL1 leading to recruitment of BRD4 and the pause release factor P-TEFb, followed by productive elongation of circadian transcripts.	Lysine	56-62	bromodomain containing 4	Mus musculus	160-164
31354407-3	2019	We report an increase in A2AR mRNA expression and protein levels in both human cells and mice striata, and in the latter we could also observe a consistent reduction in DNA methylation at gene promoter and an increase in histone H3 acetylation at lysine 9.	Lysine	247-253	adenosine A2a receptor	Homo sapiens	25-29
17121968-6	2007	By homologous comparative modeling, we predicted the molecular spatial structures of yak MT-I and MT-II, which are composed of alpha- and beta-domains that are linked by the conserved tripeptide Lys(30)-Lys(31)-Ser(32) (KKS).	Lysine	195-198	metallothionein 2A	Homo sapiens	98-103
17121968-6	2007	By homologous comparative modeling, we predicted the molecular spatial structures of yak MT-I and MT-II, which are composed of alpha- and beta-domains that are linked by the conserved tripeptide Lys(30)-Lys(31)-Ser(32) (KKS).	Lysine	203-206	metallothionein 2A	Homo sapiens	98-103
34295118-2	2021	They show mutations resulting in replacement of lysine at position 27 by methionine (K27M) of histone genes, H3F3A , HIST1H3B, and HIST1H3C.	Lysine	48-54	H3 clustered histone 3	Homo sapiens	131-139
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	lysine methyltransferase 2D	Homo sapiens	15-19
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	lysine methyltransferase 2D	Homo sapiens	20-25
34156443-3	2021	MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation.	Lysine	122-128	lysine methyltransferase 2A	Homo sapiens	87-90
34156443-5	2021	MLL3 and MLL4 form identical multi-protein complexes for modifying mono-methylation of histone H3 lysine 4 (H3K4) at enhancers, which together with the p300/CBP-mediated H3K27 acetylation can generate an active enhancer landscape for long-range target gene activation.	Lysine	98-104	lysine methyltransferase 2D	Homo sapiens	9-13
17416668-7	2007	The optimal activity of AruH was found at pH 9.0, and it has a novel substrate specificity with an order of preference of Arg &gt; Lys &gt; Met &gt; Leu &gt; Orn &gt; Gln.	Lysine	131-134	arginine:pyruvate transaminase AruH	Pseudomonas aeruginosa PAO1	24-28
31266957-6	2019	Consistent with the ability of lysine to drive phase separation, lysine-rich variants of the Alzheimer"s disease-linked protein tau undergo coacervation with RNA in vitro and bind to stress granules in cells.	Lysine	31-37	microtubule associated protein tau	Homo sapiens	128-131
17416668-7	2007	The optimal activity of AruH was found at pH 9.0, and it has a novel substrate specificity with an order of preference of Arg &gt; Lys &gt; Met &gt; Leu &gt; Orn &gt; Gln.	Lysine	131-134	oligoribonuclease	Pseudomonas aeruginosa PAO1	158-161
34221922-2	2021	To investigate whether histone H3 lysine 4 (H3K4) methyltransferase (SET7/9) and histone H3K4 demethyltransferase (LSD1/KDM1A) can regulate endoplasmic reticulum stress (ERS)-related apoptosis by modulating the changes of H3K4 methylations in liver cells treated with arsenic.	Lysine	34-40	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	69-75
17294240-2	2007	AtAGP17, 18 and 19 comprise the lysine-rich AGP subfamily in Arabidopsis and consist of an N-terminal signal peptide, a classical AGP domain interrupted by a small Lys-rich region and a C-terminal glycosylphosphatidylinositol (GPI) anchor addition sequence.	Lysine	32-38	arabinogalactan protein 17	Arabidopsis thaliana	0-7
31266957-6	2019	Consistent with the ability of lysine to drive phase separation, lysine-rich variants of the Alzheimer"s disease-linked protein tau undergo coacervation with RNA in vitro and bind to stress granules in cells.	Lysine	65-71	microtubule associated protein tau	Homo sapiens	128-131
17294240-2	2007	AtAGP17, 18 and 19 comprise the lysine-rich AGP subfamily in Arabidopsis and consist of an N-terminal signal peptide, a classical AGP domain interrupted by a small Lys-rich region and a C-terminal glycosylphosphatidylinositol (GPI) anchor addition sequence.	Lysine	164-167	arabinogalactan protein 17	Arabidopsis thaliana	0-7
34220490-8	2021	Moreover, we confirm that the interactions between PAR and alphaSyn involve electrostatic forces between negatively charged PAR and lysine residues on the N-terminal region of alphaSyn.	Lysine	132-138	synuclein alpha	Homo sapiens	59-67
34220490-8	2021	Moreover, we confirm that the interactions between PAR and alphaSyn involve electrostatic forces between negatively charged PAR and lysine residues on the N-terminal region of alphaSyn.	Lysine	132-138	synuclein alpha	Homo sapiens	176-184
31266957-7	2019	Acetylation of lysine reverses liquid-liquid phase separation and reduces colocalization of tau with stress granules.	Lysine	15-21	microtubule associated protein tau	Homo sapiens	92-95
31104332-9	2019	LNCaP and PC3 cell treatment with UNC1999 reduced histone H3 lysine 27 tri-methylation levels.	Lysine	61-67	chromobox 8	Homo sapiens	10-13
34207159-1	2021	Glutaric aciduria type I (GA-1) is a rare autosomal-recessive disorder of the degradation of the amino acids lysine and tryptophan caused by mutations of the GCDH gene encoding glutaryl-CoA-dehydrogenase.	Lysine	109-115	glutaryl-CoA dehydrogenase	Homo sapiens	158-162
34207159-1	2021	Glutaric aciduria type I (GA-1) is a rare autosomal-recessive disorder of the degradation of the amino acids lysine and tryptophan caused by mutations of the GCDH gene encoding glutaryl-CoA-dehydrogenase.	Lysine	109-115	glutaryl-CoA dehydrogenase	Homo sapiens	177-203
17403666-5	2007	Point mutations of Lys-9 and Lys-27 to block cellular modifications of the tail domains completely abolished the association of specific factors, including HP1 and several repressors.	Lysine	19-22	defensin alpha 1	Homo sapiens	156-159
17403666-5	2007	Point mutations of Lys-9 and Lys-27 to block cellular modifications of the tail domains completely abolished the association of specific factors, including HP1 and several repressors.	Lysine	29-32	defensin alpha 1	Homo sapiens	156-159
34221965-15	2021	The underlying mechanism of P7C3 was found to be direct targeting PGK1 at lysine residues and asparagine residues, and the specific P7C3-PGK1 interaction led to decreased protein level and total intracellular kinase activity of PGK1.	Lysine	74-80	phosphoglycerate kinase 1	Homo sapiens	66-70
31221220-5	2019	We find that global upregulation of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark is PRDM14 dosage dependent in PGCs of both sexes.	Lysine	62-68	PR domain containing 14	Mus musculus	106-112
34200910-2	2021	We identified lysine residues (K67, K141, and K166) that are involved in the ubiquitination of human growth hormone (hGH) using ubiquitination site prediction programs to validate the ubiquitination sites, and then substituted these lysine residues with arginine residues.	Lysine	14-20	gamma-glutamyl hydrolase	Homo sapiens	117-120
17418100-3	2007	One of the mitogen-activated protein kinase kinase kinses (MAP3Ks) members, TAK1, plays a critical role in cytokine-induced activation of NFkappaB, which involves lysine 63-linked (K63) polyubiquitination of NEMO, a noncatalytic subunit of the IkappaB kinase complex.	Lysine	163-169	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	76-80
17418100-3	2007	One of the mitogen-activated protein kinase kinase kinses (MAP3Ks) members, TAK1, plays a critical role in cytokine-induced activation of NFkappaB, which involves lysine 63-linked (K63) polyubiquitination of NEMO, a noncatalytic subunit of the IkappaB kinase complex.	Lysine	163-169	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	208-212
17517655-4	2007	Here, quantum mechanical/molecular mechanical molecular dynamics and free-energy simulations are performed on human PKMT SET7/9 and its mutants to understand two outstanding questions for the reaction catalyzed by PKMTs: the mechanism for deprotonation of positively charged methyl lysine (lysine) and origin of product specificity.	Lysine	282-288	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	121-127
31217475-5	2019	More intriguingly, FBXO22 mediates Lys-63-linked LKB1 polyubiquitination and inhibits kinase activity of LKB1.	Lysine	35-38	F-box protein 22	Homo sapiens	19-25
17212359-8	2007	The return of Lys-Ser-Arg of the AT1R to this hybrid led to almost full recovery of Galphai and Galphaq activation.	Lysine	14-17	G protein subunit alpha q	Homo sapiens	96-103
34458005-5	2021	Chromatin immunoprecipitation sequencing (ChIP-seq) showed that the genome-wide occupancy of CBX4 and histone H2A lysine-119 ubiquitination (H2AK119ub) was compromised, especially on the promoter of GnRH.	Lysine	114-120	gonadotropin releasing hormone 1	Mus musculus	199-203
31217475-5	2019	More intriguingly, FBXO22 mediates Lys-63-linked LKB1 polyubiquitination and inhibits kinase activity of LKB1.	Lysine	35-38	serine/threonine kinase 11	Homo sapiens	49-53
30996097-1	2019	The histone modifier lysine (K)-specific demethylase 2B (KDM2B) plays a role in the differentiation of hematopoietic cells, and its expression appears to be deregulated in certain cancers of hematological and lymphoid origins.	Lysine	21-27	lysine demethylase 2B	Homo sapiens	57-62
34060719-5	2021	A targeting template in the form of nonlinearised plasmid was shown to have the best efficiency and was used to introduce a substitution at position 295 in the gene encoding FOXA1 to change a codon encoding lysine into a codon encoding glutamine (K295Q).	Lysine	207-213	forkhead box A1	Homo sapiens	174-179
17329242-6	2007	Mutations of the GatA catalytic triad residues (Lys(52), Ser(128), Ser(152)) abolished glutaminase activity and consequently the amidotransferase activity with glutamine as the amide donor.	Lysine	48-51	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	17-21
17392790-5	2007	The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction.	Lysine	4-7	mitochondrial antiviral signaling protein	Homo sapiens	94-98
31196146-0	2019	Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.	Lysine	95-101	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	44-47
34108663-2	2021	DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation of a single lysine (K1268) by the CRL4CSA ubiquitin ligase.	Lysine	138-144	interleukin 17 receptor B	Homo sapiens	160-164
31018997-2	2019	Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on histone tails, has recently been reported to promote gene transcription of proinflammatory cytokines but has rarely been explored for its role in IL4-driven MTheta transcriptional programming and MTheta-mediated immunosuppression in the TME.	Lysine	77-83	bromodomain containing 4	Mus musculus	45-49
34458803-1	2021	Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues.	Lysine	139-145	sirtuin 2	Homo sapiens	0-9
17389369-7	2007	Comparison of two crystal structures of the Skp1-Fbs1 complex revealed the relative motion of a linker segment between the F-box and the SBD domains, which might underlie the ability of the complex to recognize different acceptor lysine residues for ubiquitination.	Lysine	230-236	S-phase kinase associated protein 1	Homo sapiens	44-48
31018997-2	2019	Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on histone tails, has recently been reported to promote gene transcription of proinflammatory cytokines but has rarely been explored for its role in IL4-driven MTheta transcriptional programming and MTheta-mediated immunosuppression in the TME.	Lysine	77-83	interleukin 4	Mus musculus	233-236
17489361-6	2007	The block of HERG by maprotiline was examined after treatment of trinitrobenzene sulfonic acid (TNBS), an amino-group reagent that neutralizes the positively charged amino-groups of peptide N-terminal and lysine residues.	Lysine	205-211	potassium voltage-gated channel subfamily H member 2	Homo sapiens	13-17
34458803-1	2021	Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues.	Lysine	139-145	sirtuin 2	Homo sapiens	11-16
30804456-3	2019	Here we show that the IL-6/STAT3 inflammatory signaling axis induces the deacetylation of FRA1 at the Lys-116 residue located within its DNA-binding domain.	Lysine	102-105	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	90-94
34705580-1	2021	To investigate the function of histone-lysine N-methyltransferase 2D (KMT2D) on the methylation of H3 lysine 4 (H3K4) in the progression of Ovarian cancer (OV).	Lysine	102-108	lysine methyltransferase 2D	Homo sapiens	31-68
34705580-1	2021	To investigate the function of histone-lysine N-methyltransferase 2D (KMT2D) on the methylation of H3 lysine 4 (H3K4) in the progression of Ovarian cancer (OV).	Lysine	102-108	lysine methyltransferase 2D	Homo sapiens	70-75
34179318-5	2021	Overexpression of cTnIR193H mutant in cardiomyocytes showed decrease in PDED4D protein expression, while the enrichment of histone deacetylase 1 (HDAC1) was increased along with decreases in acetylated lysine 4 (acH3K4) and 9 (acH3K9) levels in the PDE4D promoter.	Lysine	202-208	phosphodiesterase 4D, cAMP specific	Mus musculus	249-254
30942586-2	2019	NPC1 is believed to act in tandem with NPC2, transferring cholesterol and other sterols out of the LE/Lys compartments.	Lysine	102-105	NPC intracellular cholesterol transporter 1	Homo sapiens	0-4
17272500-6	2007	Quantitative polymerase chain reaction analysis of precipitated DNA unravels biphasic heterochromatin assembly on OCT4 and NANOG, involving H3 lysine (K)9 and K27 methylation followed by H3K9 deacetylation and additional H3K27 trimethylation.	Lysine	143-149	POU class 5 homeobox 1	Homo sapiens	114-118
31034218-0	2019	Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation.	Lysine	63-69	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	46-52
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	8-14	keratin 79	Homo sapiens	128-131
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	84-91	keratin 79	Homo sapiens	128-131
17267293-4	2007	Epistasis analysis between dot1 and various UV repair genes indicates that lysine-79 methylation plays overlapping roles within the nucleotide excision, post-replication and recombination repair pathways, as well as RAD9-mediated checkpoint function.	Lysine	75-81	chromatin-binding protein RAD9	Saccharomyces cerevisiae S288C	216-220
35354308-8	2022	Subsequent RNA-seq, proteomics, and immunoprecipitation experiments showed that wild-type ALDH2 directly interacted with Rac2 and attenuated its degradation due to decreasing the K48-linked polyubiquitination of lysine 123 in Rac2, whereas the rs671 mutant markedly destabilized Rac2.	Lysine	212-218	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	90-95
35358824-2	2022	The enzymatic activity of SIRT2 is dependent on nicotinamide adenine dinucleotide (NAD+) and SIRT2 regulates post-translational modifications that are responsible for deacetylation of lysine residues in histone and non-histone substrates.	Lysine	184-190	sirtuin 2	Homo sapiens	26-31
35358824-2	2022	The enzymatic activity of SIRT2 is dependent on nicotinamide adenine dinucleotide (NAD+) and SIRT2 regulates post-translational modifications that are responsible for deacetylation of lysine residues in histone and non-histone substrates.	Lysine	184-190	sirtuin 2	Homo sapiens	93-98
31000437-5	2019	Mutation of the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic acid significantly decreases its stability and activity.	Lysine	33-40	uncoupling protein 1	Homo sapiens	44-48
35136209-8	2022	Mechanistically, KDM6A promotes the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently leads to the inactivation of p65.	Lysine	89-95	SPARC like 1	Homo sapiens	53-60
17132685-5	2007	Alpha4, alpha5, and beta3 subunits all have a homologous glutamate in M2 that contributes to high Ca2+ permeability, whereas beta2 has a lysine at this position.	Lysine	137-143	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	8-25
31064153-2	2019	In our previous works, we have obtained several submicromolar inhibitors of this interaction, including branched pentapeptides of general structure Lys(Har)-Xxx-Xxx-Arg.	Lysine	148-151	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	152-155
17166591-5	2007	In typical individuals, the chromatin remodeling indicated by the induction of hyper-acetylation of histone H3 lysine 9 and hyper-methylation of histone H3 lysine 4 was induced at the whole Th2 cytokine gene loci in developing Th2 cells.	Lysine	156-162	heart and neural crest derivatives expressed 2	Mus musculus	190-193
35501461-8	2022	Mechanistically, Nedd4 enhanced TGF-beta signal transduction mediated tumor progression by directly binding to TGF-beta type I receptor (TGFBR1) and forming K27-linked ubiquitin at Lysine 391.	Lysine	181-187	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	17-22
17329434-7	2007	In the channel complex, lysine residue 121 within the N-terminal domain of the channel activates SK2-bound CK2, and phosphorylation of CaM is state dependent, occurring only when the channels are closed.	Lysine	24-30	potassium calcium-activated channel subfamily N member 2	Homo sapiens	97-100
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	123-129	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	66-70
17121856-6	2007	Furthermore, the co-activator complexes initiate the recruitment of the components of the basal transcription apparatus to the basal promoter with markedly different outcomes because only Ac-Lys-373 p53 promotes the assembly of the basal transcriptional apparatus on the p21 promoter.	Lysine	191-194	H3 histone pseudogene 16	Homo sapiens	271-274
35595215-8	2022	CONCLUSIONS: The identification of the post-lysine pocket as a cryptic druggable vulnerability in the RET kinase and its exploitation by second generation RET inhibitors has important implications for future drug design and the development of personalized therapies for patients with RET-driven cancers.	Lysine	44-50	ret proto-oncogene	Homo sapiens	102-105
35595215-8	2022	CONCLUSIONS: The identification of the post-lysine pocket as a cryptic druggable vulnerability in the RET kinase and its exploitation by second generation RET inhibitors has important implications for future drug design and the development of personalized therapies for patients with RET-driven cancers.	Lysine	44-50	ret proto-oncogene	Homo sapiens	155-158
35595215-8	2022	CONCLUSIONS: The identification of the post-lysine pocket as a cryptic druggable vulnerability in the RET kinase and its exploitation by second generation RET inhibitors has important implications for future drug design and the development of personalized therapies for patients with RET-driven cancers.	Lysine	44-50	ret proto-oncogene	Homo sapiens	284-287
35503863-5	2022	MARCH8 interacted with the enzymatically active core of cGAS through its conserved RING-CH domain and catalyzed the lysine-63 (K63)-linked polyubiquitylation of cGAS at Lys411.	Lysine	116-122	cyclic GMP-AMP synthase	Homo sapiens	56-60
35503863-5	2022	MARCH8 interacted with the enzymatically active core of cGAS through its conserved RING-CH domain and catalyzed the lysine-63 (K63)-linked polyubiquitylation of cGAS at Lys411.	Lysine	116-122	cyclic GMP-AMP synthase	Homo sapiens	161-165
17243773-0	2007	Free energy of transition for the individual alkaline conformers of yeast iso-1-cytochrome c. Direct protein electrochemistry was used to obtain the thermodynamic parameters of transition from the native (state III) to the alkaline (state IV) conformer for untrimethylated Saccharomyces cerevisiae iso-1-cytochrome c expressed in E. coli and its single and multiple lysine-depleted variants.	Lysine	366-372	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	74-79
30776335-4	2019	Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.	Lysine	143-149	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	66-70
35231567-0	2022	Methylation at a conserved lysine residue modulates tau assembly and cellular functions.	Lysine	27-33	microtubule associated protein tau	Homo sapiens	52-55
35231567-3	2022	In contrast with other well-studied tau post-translational modifications such as phosphorylation, lysine methylation is far less investigated and its specific impact on tau biology is not fully understood.	Lysine	98-104	microtubule associated protein tau	Homo sapiens	36-39
30590679-2	2019	We previously showed that mammalian HP1alpha is constitutively phosphorylated at its N-terminal serine residues by casein kinase II (CK2), and that this phosphorylation enhances HP1alpha"s binding specificity for nucleosomes containing lysine 9-methylated histone H3 (H3K9me).	Lysine	236-242	chromobox 5	Homo sapiens	36-44
35231567-3	2022	In contrast with other well-studied tau post-translational modifications such as phosphorylation, lysine methylation is far less investigated and its specific impact on tau biology is not fully understood.	Lysine	98-104	microtubule associated protein tau	Homo sapiens	169-172
35449131-3	2022	Here, we identify that SNIP1 is a non-histone substrate of lysine methyltransferase KMT5A, which undergoes KMT5A-mediated mono-methylation to promote breast cancer cell growth, invasion and lung metastasis.	Lysine	59-65	Smad nuclear interacting protein 1	Homo sapiens	23-28
17242436-0	2007	Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.	Lysine	0-6	beta-2-microglobulin	Homo sapiens	18-37
17242436-1	2007	The lysine 58 cleaved and truncated variant of beta(2)-microglobulin (DeltaK58-beta2m) is conformationally unstable and present in the circulation of a large percentage of patients on chronic hemodialysis, suggesting that it could play a role in the beta2-microglobulin (beta2m) amyloid fibrillogenesis associated with dialysis-related amyloidosis (DRA).	Lysine	4-10	beta-2-microglobulin	Homo sapiens	47-68
17242436-1	2007	The lysine 58 cleaved and truncated variant of beta(2)-microglobulin (DeltaK58-beta2m) is conformationally unstable and present in the circulation of a large percentage of patients on chronic hemodialysis, suggesting that it could play a role in the beta2-microglobulin (beta2m) amyloid fibrillogenesis associated with dialysis-related amyloidosis (DRA).	Lysine	4-10	beta-2-microglobulin	Homo sapiens	79-85
35452614-5	2022	In eukaryotes, this process exposes ribosome-buried nascent-chain lysines, the ubiquitin acceptor sites, to LTN1.	Lysine	66-73	listerin E3 ubiquitin protein ligase 1	Homo sapiens	108-112
17242436-1	2007	The lysine 58 cleaved and truncated variant of beta(2)-microglobulin (DeltaK58-beta2m) is conformationally unstable and present in the circulation of a large percentage of patients on chronic hemodialysis, suggesting that it could play a role in the beta2-microglobulin (beta2m) amyloid fibrillogenesis associated with dialysis-related amyloidosis (DRA).	Lysine	4-10	beta-2-microglobulin	Homo sapiens	250-269
30590679-2	2019	We previously showed that mammalian HP1alpha is constitutively phosphorylated at its N-terminal serine residues by casein kinase II (CK2), and that this phosphorylation enhances HP1alpha"s binding specificity for nucleosomes containing lysine 9-methylated histone H3 (H3K9me).	Lysine	236-242	chromobox 5	Homo sapiens	178-186
17242436-1	2007	The lysine 58 cleaved and truncated variant of beta(2)-microglobulin (DeltaK58-beta2m) is conformationally unstable and present in the circulation of a large percentage of patients on chronic hemodialysis, suggesting that it could play a role in the beta2-microglobulin (beta2m) amyloid fibrillogenesis associated with dialysis-related amyloidosis (DRA).	Lysine	4-10	beta-2-microglobulin	Homo sapiens	271-277
30872404-3	2019	Viperin is also implicated in regulating Lys-63-linked polyubiquitination of interleukin-1 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signaling pathways.	Lysine	41-44	TNF receptor associated factor 6	Homo sapiens	207-212
17243194-3	2007	In budding yeast, methylation of histone H3 on lysine 79 (H3-K79me) has been shown to be required for efficient checkpoint signalling and Rad9 localization on chromatin.	Lysine	47-53	chromatin-binding protein RAD9	Saccharomyces cerevisiae S288C	138-142
35440627-4	2022	We report 276 NEDD4 targets in NCCs and show that loss of NEDD4 leads to a pronounced global reduction in specific ubiquitin lysine linkages.	Lysine	125-131	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	14-19
35440627-4	2022	We report 276 NEDD4 targets in NCCs and show that loss of NEDD4 leads to a pronounced global reduction in specific ubiquitin lysine linkages.	Lysine	125-131	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	58-63
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Lysine	99-102	thyrotropin-releasing hormone	Oryzias latipes	11-16
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Lysine	127-130	thyrotropin-releasing hormone	Oryzias latipes	11-16
30986062-0	2019	Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.	Lysine	6-12	sirtuin 2	Mus musculus	62-71
17210687-4	2007	This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine.	Lysine	152-158	zinc finger CCCH-type containing 12D	Homo sapiens	30-37
17210687-4	2007	This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine.	Lysine	152-158	zinc finger CCCH-type containing 12D	Homo sapiens	39-46
35399062-3	2022	The decrease in HDA6 binding to target DNA mirrors histone H4 acetylation (H4Ac) changes during JA-mediated drought response, and mutations in HDA6 also cause depletion in the constitutive repressive marker H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	histone deacetylase 6	Arabidopsis thaliana	16-20
35399062-3	2022	The decrease in HDA6 binding to target DNA mirrors histone H4 acetylation (H4Ac) changes during JA-mediated drought response, and mutations in HDA6 also cause depletion in the constitutive repressive marker H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	histone deacetylase 6	Arabidopsis thaliana	143-147
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	219-246
35403701-3	2022	In this study, we show that ABA affects the Polycomb Repressive Complex 2 (PRC2)-mediated Histone H3 Lys 27 trimethylation (H3K27me3) through VIN3-LIKE1/VERNALIZATION 5 (VIL1/VRN5) to fine-tune the timely repression of ABSCISIC ACID INSENSITIVE 3 (ABI3) and ABSCISIC ACID INSENSITIVE 4 (ABI4) in Arabidopsis thaliana.	Lysine	101-104	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	248-252
17101786-3	2007	Methylation of lysine 9 within histone H3 and the subsequent binding of the chromodomain protein heterochromatin protein 1 (HP1) are thought to initiate heterochromatin formation in vivo and to propagate a heterochromatic state lasting through several cell divisions.	Lysine	15-21	chromobox 5	Homo sapiens	97-122
30986062-0	2019	Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.	Lysine	6-12	sirtuin 2	Mus musculus	73-78
35455942-4	2022	Here, we show for the first time that deficiency or pharmacological inhibition of the cellular lysine-methyltransferase SMYD2 decreases TMPRSS2 expression on both mRNA and protein levels.	Lysine	95-101	SET and MYND domain containing 2	Homo sapiens	120-125
30986062-3	2019	Here, we report the facile synthesis of novel lysine-derived thioureas as mechanism-based SIRT2 inhibitors with anticancer activity.	Lysine	46-52	sirtuin 2	Mus musculus	90-95
31015455-4	2019	Lysine 27-linked ubiquitination of BRAF recruits PP2A to antagonize the S365 phosphorylation and disrupts the inhibitory interaction with 14-3-3, leading to sustained BRAF activation and subsequent elevation of the MEK/ERK signaling.	Lysine	0-6	protein phosphatase 2 phosphatase activator	Homo sapiens	49-53
17101786-3	2007	Methylation of lysine 9 within histone H3 and the subsequent binding of the chromodomain protein heterochromatin protein 1 (HP1) are thought to initiate heterochromatin formation in vivo and to propagate a heterochromatic state lasting through several cell divisions.	Lysine	15-21	chromobox 5	Homo sapiens	124-127
35302733-5	2022	These flexible bowl-shaped receptors can be easily functionalized with different motifs at the upper and lower rim, and the large cavities can bind many different fluorescent dyes, causing either fluorescence enhancement or quenching upon binding.Cavity-based affinity is strongest for NMe3+ groups such as trimethyl-lysine, and we have exploited this for the site-selective recognition of post-translational lysine methylations in oligopeptides.	Lysine	409-415	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	286-290
17101786-6	2007	However, the addition of recombinant SU(VAR) protein, such as ACF1 or SU(VAR)3-9, facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9).	Lysine	133-139	chromobox 5	Homo sapiens	94-97
30734528-0	2019	A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.	Lysine	55-61	sirtuin 2	Homo sapiens	17-22
17101788-0	2007	Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.	Lysine	39-45	growth factor receptor bound protein 10	Mus musculus	100-105
17101788-7	2007	Histone modification analysis showed that allelic methylation of histone H3 lysine 4 and H3 lysine 9 were associated with gametic DNA methylation in the brain type promoter, whereas that of H3 lysine 27 regulated by the Eed PcG complex was detected in the paternal major-type promoter, corresponding to its allele-specific silencing.	Lysine	76-82	embryonic ectoderm development	Mus musculus	220-223
17130289-2	2006	In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3) yRad18 promotes translesion synthesis (TLS), whereas the lysine-63-linked polyubiquitination of PCNA by yRad5 (E3) promotes the error-free mode of bypass.	Lysine	120-126	proliferating cell nuclear antigen	Homo sapiens	10-14
17130289-2	2006	In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3) yRad18 promotes translesion synthesis (TLS), whereas the lysine-63-linked polyubiquitination of PCNA by yRad5 (E3) promotes the error-free mode of bypass.	Lysine	120-126	proliferating cell nuclear antigen	Homo sapiens	159-163
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	88-94	Cbl proto-oncogene B	Homo sapiens	44-49
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	88-94	signal transducer and activator of transcription 5A	Mus musculus	102-108
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	88-94	Cbl proto-oncogene	Homo sapiens	115-120
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	158-164	Cbl proto-oncogene	Homo sapiens	115-120
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	158-164	signal transducer and activator of transcription 5A	Mus musculus	172-178
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	158-164	signal transducer and activator of transcription 5B	Mus musculus	234-240
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	212-218	Cbl proto-oncogene B	Homo sapiens	44-49
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	212-218	signal transducer and activator of transcription 5A	Mus musculus	102-108
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	212-218	Cbl proto-oncogene	Homo sapiens	115-120
17049505-6	2006	l-Lysine up-regulated p53, p21, and Bax protein levels and a down-regulation of Bcl-2alpha in all the cell lines tested.	Lysine	0-8	H3 histone pseudogene 16	Homo sapiens	27-30
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	212-218	signal transducer and activator of transcription 5A	Mus musculus	172-178
17079264-3	2006	Previous work has shown that the upregulation of FLC in FRI- or AP-mutant backgrounds is correlated to an increase in histone H3 lysine 4 (H3K4) trimethylation at the FLC locus.	Lysine	129-135	FRIGIDA-like protein	Arabidopsis thaliana	56-59
35135854-3	2022	Here we report that Aass mutant male and female mice carrying the R65Q mutation in alpha-ketoglutarate reductase (LKR) domain have an elevated cerebral lysine level and a normal brain development, whereas the Aass mutant mice carrying the G489E mutation in saccharopine dehydrogenase (SDH) domain exhibit elevations of both cerebral lysine and saccharopine levels and a smaller brain with defective neuronal development.	Lysine	152-158	aminoadipate-semialdehyde synthase	Mus musculus	20-24
30734528-5	2019	Herein we report a SIRT2 inhibitor, JH-T4, which can increase K-Ras4a lysine fatty acylation.	Lysine	70-76	sirtuin 2	Homo sapiens	19-24
35135854-3	2022	Here we report that Aass mutant male and female mice carrying the R65Q mutation in alpha-ketoglutarate reductase (LKR) domain have an elevated cerebral lysine level and a normal brain development, whereas the Aass mutant mice carrying the G489E mutation in saccharopine dehydrogenase (SDH) domain exhibit elevations of both cerebral lysine and saccharopine levels and a smaller brain with defective neuronal development.	Lysine	152-158	aminoadipate-semialdehyde synthase	Mus musculus	114-117
35135854-3	2022	Here we report that Aass mutant male and female mice carrying the R65Q mutation in alpha-ketoglutarate reductase (LKR) domain have an elevated cerebral lysine level and a normal brain development, whereas the Aass mutant mice carrying the G489E mutation in saccharopine dehydrogenase (SDH) domain exhibit elevations of both cerebral lysine and saccharopine levels and a smaller brain with defective neuronal development.	Lysine	333-339	aminoadipate-semialdehyde synthase	Mus musculus	20-24
35135854-3	2022	Here we report that Aass mutant male and female mice carrying the R65Q mutation in alpha-ketoglutarate reductase (LKR) domain have an elevated cerebral lysine level and a normal brain development, whereas the Aass mutant mice carrying the G489E mutation in saccharopine dehydrogenase (SDH) domain exhibit elevations of both cerebral lysine and saccharopine levels and a smaller brain with defective neuronal development.	Lysine	333-339	aminoadipate-semialdehyde synthase	Mus musculus	114-117
35135854-3	2022	Here we report that Aass mutant male and female mice carrying the R65Q mutation in alpha-ketoglutarate reductase (LKR) domain have an elevated cerebral lysine level and a normal brain development, whereas the Aass mutant mice carrying the G489E mutation in saccharopine dehydrogenase (SDH) domain exhibit elevations of both cerebral lysine and saccharopine levels and a smaller brain with defective neuronal development.	Lysine	333-339	aminoadipate-semialdehyde synthase	Mus musculus	209-213
31105998-7	2019	Chromatin immunoprecipitation (ChIP) assay indicated that MALAT1 regulated EEF1A1 by altering the histone 3 lysine 4 (H3K4) epigenotype in the gene promoter.	Lysine	108-114	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	58-64
35135854-7	2022	Here, we report that mice carrying the R65Q mutation in LKR domain of AASS have an elevated cerebral lysine levels and a normal brain development, whereas those carrying the G489E mutation in SDH domain of AASS exhibit an elevation of both cerebral lysine and saccharopine and a small brain with defective neuronal development.	Lysine	101-107	aminoadipate-semialdehyde synthase	Mus musculus	56-59
35135854-7	2022	Here, we report that mice carrying the R65Q mutation in LKR domain of AASS have an elevated cerebral lysine levels and a normal brain development, whereas those carrying the G489E mutation in SDH domain of AASS exhibit an elevation of both cerebral lysine and saccharopine and a small brain with defective neuronal development.	Lysine	101-107	aminoadipate-semialdehyde synthase	Mus musculus	70-74
35135854-7	2022	Here, we report that mice carrying the R65Q mutation in LKR domain of AASS have an elevated cerebral lysine levels and a normal brain development, whereas those carrying the G489E mutation in SDH domain of AASS exhibit an elevation of both cerebral lysine and saccharopine and a small brain with defective neuronal development.	Lysine	249-255	aminoadipate-semialdehyde synthase	Mus musculus	70-74
35135854-7	2022	Here, we report that mice carrying the R65Q mutation in LKR domain of AASS have an elevated cerebral lysine levels and a normal brain development, whereas those carrying the G489E mutation in SDH domain of AASS exhibit an elevation of both cerebral lysine and saccharopine and a small brain with defective neuronal development.	Lysine	249-255	aminoadipate-semialdehyde synthase	Mus musculus	192-195
35135854-7	2022	Here, we report that mice carrying the R65Q mutation in LKR domain of AASS have an elevated cerebral lysine levels and a normal brain development, whereas those carrying the G489E mutation in SDH domain of AASS exhibit an elevation of both cerebral lysine and saccharopine and a small brain with defective neuronal development.	Lysine	249-255	aminoadipate-semialdehyde synthase	Mus musculus	206-210
16980404-5	2006	All examined SHMT contain an 8-amino-acid conserved sequence, VTTTTHKT, containing the active-site lysyl residue (Lys 251 in TvSHMT) that forms an internal aldimine with PLP.	Lysine	114-117	serine hydroxymethyltransferase 1	Homo sapiens	13-17
30631151-2	2019	Herein, we show that up-regulated E2 conjugating enzyme UBC9 sumoylates Flot-1 at Lys-51 and Lys-195 with small ubiquitin-like modifier (SUMO)-2/3 modification in metastatic prostate cancer.	Lysine	82-85	flotillin 1	Homo sapiens	72-78
16997281-2	2006	In this study we produced, and expressed in Xenopus oocytes, individual alanine point mutants of positively charged amino acids (eight lysine, seven arginine and one histidine) in the intracellular domains of the human P2X1 receptor.	Lysine	135-141	purinergic receptor P2X 1	Homo sapiens	219-232
35346195-13	2022	Mechanistically, we demonstrated that BMI1 directly binds to the promoter region of SIK1 in a complex with RING1B to promote monoubiquitination of histone H2A at lysine 119 (H2AK119ub) and inhibit H3K4 trimethylation (H3K4me3), resulting in inhibition of SIK1 transcription.	Lysine	162-168	salt inducible kinase 1	Homo sapiens	84-88
30881498-6	2019	Furthermore, treating cells with resveratrol upregulated SET domain containing lysine methyltransferase 7/9 (SET7/9) expression, which positively regulates p53 through its mono-methylation at lysine 372, compared with untreated cells.	Lysine	79-85	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	109-115
35350980-15	2022	Mechanistic research indicated that MZF1, SETD8, and its downstream target histone H4 lysine 20 methylation (H4K20me1) all occupied the WNT5A promoter region.	Lysine	86-92	myeloid zinc finger 1	Rattus norvegicus	36-40
35317899-1	2022	Objective: SET8 is a member of the SET domain-containing family and the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20me1).	Lysine	134-140	H4 clustered histone 6	Homo sapiens	147-157
16965397-7	2006	Loss of expression of LIT1 also correlated with enrichment of H3 lysine 9 (H3-K9) dimethylation and reduction of H3 lysine 4 (H3-K4) dimethylation.	Lysine	65-71	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	22-26
16965397-7	2006	Loss of expression of LIT1 also correlated with enrichment of H3 lysine 9 (H3-K9) dimethylation and reduction of H3 lysine 4 (H3-K4) dimethylation.	Lysine	116-122	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	22-26
16996234-0	2006	Determination of interleukin-1alpha in human NCTC 2544 keratinocyte cells as a predictor of skin irritation from lysine-based surfactants.	Lysine	113-119	interleukin 1 alpha	Homo sapiens	17-35
16996234-5	2006	Lysine derivatives proved to be less potent in stimulating IL-1 alpha synthesis and induced a lower release of this cytokine into the culture medium when compared to the anionic surfactant sodium dodecyl sulfate.	Lysine	0-6	interleukin 1 alpha	Homo sapiens	59-69
30877853-1	2019	Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence.	Lysine	51-57	sirtuin 1	Mus musculus	0-9
16926151-7	2006	Importantly, coordinate activation of Akt/p300 pathway by suberoylanilide hydroxamic acid occurs at the chromatin level, resulting in recruitment of activated Akt (pSer(473)), p300 (pSer(1834)), acetylated RelA/p65 (Lys(310)), and RNA polymerase II to the NF-kappaB-dependent cIAP-2 and Bfl-1/A1 promoters.	Lysine	216-219	baculoviral IAP repeat containing 3	Homo sapiens	276-282
35292818-1	2022	AIMS: Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L).	Lysine	34-40	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	148-153
35296809-2	2022	Here, we show that histone lysine 4 dimethylation (H3K4me2), a histone mark linked to gene activation, is significantly decreased in the prefrontal cortex (PFC) of autistic human patients and mutant mice with the deficiency of top-ranking autism risk factor Shank3 or Cul3.	Lysine	27-33	SH3 and multiple ankyrin repeat domains 3	Mus musculus	258-264
30877853-1	2019	Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence.	Lysine	51-57	sirtuin 1	Mus musculus	11-16
35016968-4	2022	We ubiquitinated the lysine-rich, four-repeat domain of tau either unspecifically via enzymatic conjugation or in a position-specific manner by semisynthesis.	Lysine	21-27	microtubule associated protein tau	Homo sapiens	56-59
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Lysine	35-38	retinoic acid receptor alpha	Homo sapiens	186-214
31217782-0	2019	The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer.	Lysine	60-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-35
35243537-1	2022	Hypusination is a unique two-step enzymatic post-translational modification of the Nepsilon-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A).	Lysine	107-113	eukaryotic translation initiation factor 5A	Homo sapiens	124-155
16877758-6	2006	Interestingly, US11 was still capable of dislocating the lysine-less heavy chains into the cytosol.	Lysine	57-63	membrane glycoprotein US11	Human betaherpesvirus 5	15-19
30840891-6	2019	IPMK enhances autophagy-related transcription by stimulating AMPK-dependent Sirt-1 activation, which mediates the deacetylation of histone 4 lysine 16.	Lysine	141-147	inositol polyphosphate multikinase	Mus musculus	0-4
16877758-9	2006	This lysine-less fusion protein was still dislocated in the presence of US11.	Lysine	5-11	membrane glycoprotein US11	Human betaherpesvirus 5	72-76
16643891-3	2006	We earlier reported that angiostatin binds to cell surface annexin II through the lysine-binding domain (kringles 1-4) [Tuszynski, G.P., Sharma, M., Rothman, V.L., Sharma, M.C., 2002.	Lysine	82-88	annexin A2	Mus musculus	59-69
16643891-4	2006	Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells.	Lysine	70-76	annexin A2	Mus musculus	47-57
35243537-1	2022	Hypusination is a unique two-step enzymatic post-translational modification of the Nepsilon-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A).	Lysine	107-113	eukaryotic translation initiation factor 5A	Homo sapiens	157-162
30840891-6	2019	IPMK enhances autophagy-related transcription by stimulating AMPK-dependent Sirt-1 activation, which mediates the deacetylation of histone 4 lysine 16.	Lysine	141-147	sirtuin 1	Mus musculus	76-82
35330113-0	2022	The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response.	Lysine	12-18	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	37-43
30833722-4	2019	Small molecules targeting the reactive lysine residue (Lys907) in IRE1alpha"s RNase domain have been shown to inhibit the cleavage of XBP1 mRNA.	Lysine	39-45	X-box binding protein 1	Homo sapiens	134-138
16867982-6	2006	For core, the lysine residue at position 96, a potential target for ubiquitination, was identified to be essential for both gamma2-adaptin-recognition and virus production.	Lysine	14-20	adaptor related protein complex 1 subunit gamma 2	Homo sapiens	124-138
30281815-11	2019	DDX5 overexpression decreased p62/TRAF6-mediated lysine 63-linked ubiquitination of mammalian target of rapamycin (mTOR) and subsequently inhibited the mTOR signaling pathway.	Lysine	49-55	DEAD-box helicase 5	Homo sapiens	0-4
16904644-4	2006	We identified by point mutation that lysine 657 of MEF is the site for sumoylation.	Lysine	37-43	E74 like ETS transcription factor 4	Homo sapiens	51-54
35074526-5	2022	Mechanism study suggests that ECL covalently modifies a previously undisclosed lysine 46 (K46) in H2B, and recruits E3 ubiquitin ligase RNF20 to promote H2Bub1 at K120.	Lysine	79-85	H2B clustered histone 21	Homo sapiens	98-101
35371306-5	2022	In addition, we found that DDX21 directly recruited WDR5 to enhance trimethylation of histone H3 on Lys 4 (H3K4me3) on the CDK1 promoter.	Lysine	100-103	cyclin dependent kinase 1	Homo sapiens	123-127
30281815-11	2019	DDX5 overexpression decreased p62/TRAF6-mediated lysine 63-linked ubiquitination of mammalian target of rapamycin (mTOR) and subsequently inhibited the mTOR signaling pathway.	Lysine	49-55	TNF receptor associated factor 6	Homo sapiens	34-39
30741721-3	2019	We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-beta), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb).	Lysine	301-307	phosphatase and tensin homolog	Homo sapiens	49-53
35228151-7	2022	The PDB identifications 2PVC (DNMT3L recognizes unmethylated histone H3 lysine 4), 4U7P (Crystal structure of DNMT3A-DNMT3L complex and 2FGF (Human Basic Fibroblast Growth Factor) were downloaded from Protein Data Bank.	Lysine	72-78	DNA methyltransferase 3 like	Homo sapiens	30-36
16981702-1	2006	Aminopeptidase B (EC 3.4.11.6, ApB) specifically cleaves in vitro the N-terminal Arg or Lys residue from peptides and synthetic derivatives.	Lysine	88-91	arginyl aminopeptidase	Rattus norvegicus	0-16
16835244-0	2006	Inhibitory activity of the Drosophila melanogaster serpin Necrotic is dependent on lysine residues in the D-helix.	Lysine	83-89	Serpin 88Ea	Drosophila melanogaster	51-57
16835244-8	2006	These data demonstrate a critical role for basic residues within the D-helix (and lysine 68 in particular) in the inhibitory mechanism of the serpin Necrotic.	Lysine	82-88	Serpin 88Ea	Drosophila melanogaster	142-148
30783079-5	2019	Dihydroartemisinin control of miR-34a and miR-7 expression leads to inhibition of Axl expression in a process at least partially dependent on regulation of chromatin via methylation of histone H3 lysine 27 residues by Jumonji, AT-rich interaction domain containing 2 (JARID2), and the enhancer of zeste homolog 2.	Lysine	196-202	AXL receptor tyrosine kinase	Homo sapiens	82-85
16946709-4	2006	We also demonstrate that acetylation of lysine 320 (K320) of p53 is specifically involved in the promotion of neurite outgrowth and in the regulation of the expression of Coronin 1b and Rab13.	Lysine	40-46	transformation related protein 53, pseudogene	Mus musculus	61-64
35080852-7	2022	In this study, an ELP named YKV was designed to include tyrosine residues and lysine residues, which contain amine groups.	Lysine	78-84	nuclear receptor subfamily 5 group A member 1	Homo sapiens	18-21
35149557-7	2022	These findings define reversible lysine myristoylation as a mechanism for controlling GPCR signaling and highlight the potential of inhibiting HDAC11 to manipulate adipocyte phenotypes for therapeutic purposes.	Lysine	33-39	histone deacetylase 11	Homo sapiens	143-149
30777878-1	2019	In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines.	Lysine	162-169	histone acetyltransferase GCN5	Saccharomyces cerevisiae S288C	63-67
35197979-4	2022	We further demonstrated that BmTCTP could be modified by SUMOylation molecular BmSMT3 at the lysine 164 via the conjugating enzyme BmUBC9, and the stable SUMOylation of BmTCTP by expressing BmTCTP-BmSMT3 fusion protein exhibited strong antiviral activity, which confirmed that the SUMOylation of BmTCTP would contribute to its immune responses.	Lysine	93-99	ubiquitin-like protein SMT3	Bombyx mori	79-85
16571649-6	2006	XPD codon 751 Lys/Gln and Gln/Gln genotypes, compared with Lys/Lys genotype, were both associated with a more than doubled risk for esophageal adenocarcinoma (OR=2.4; 95% CI=1.4-4.4; OR=2.7, 95% CI=1.3-5.9).	Lysine	14-17	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-3
30595380-9	2019	Furthermore, PICOT knock-down in Jurkat T cells resulted in a reduced histone H3 lysine 27 trimethylation (H3K27me3) at the PRC2 target gene, myelin transcription factor 1 (MYT1), suggesting that PICOT binding to EED alters PRC2-regulated transcriptional repression, and potentially contributes to the epigenetic regulation of chromatin silencing and remodeling.	Lysine	81-87	glutaredoxin 3	Homo sapiens	13-18
16943427-0	2006	Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage.	Lysine	28-34	transformation related protein 53, pseudogene	Mus musculus	21-24
35110531-8	2022	OTUB2 mechanically stabilized KRT80 by deubiquitinating and shielding it from proteasome-mediated degradation through Lys-48 and Lys-63.	Lysine	118-121	keratin 80	Homo sapiens	30-35
35110531-8	2022	OTUB2 mechanically stabilized KRT80 by deubiquitinating and shielding it from proteasome-mediated degradation through Lys-48 and Lys-63.	Lysine	129-132	keratin 80	Homo sapiens	30-35
35100024-8	2022	Mechanistical studies reveal that high salt increases acetylated histone 3 lysine 27 (H3K27ac) on SIRT3 promoter in hepatocytes, thus inhibiting the binding of NRF2, and results in the sustained inhibition of SIRT3 expression.	Lysine	75-81	sirtuin 3	Mus musculus	98-103
16943427-0	2006	Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage.	Lysine	28-34	transformation related protein 53, pseudogene	Mus musculus	60-63
30573525-3	2019	In Caenorhbditis elegans, mutations in the saccharopine dehydrogenase (SDH) domain of the bi-functional enzyme alpha-aminoadipic semialdehyde synthase AASS-1 greatly elevate the lysine catabolic intermediate saccharopine, which causes mitochondrial damage by disrupting mitochondrial dynamics, leading to reduced adult animal growth.	Lysine	178-184	aminoadipate-semialdehyde synthase	Mus musculus	43-69
16943427-2	2006	Mouse p53 is acetylated at lysine 317 by PCAF and at multiple lysine residues at the extreme carboxyl terminus by CBP/p300 in response to genotoxic and some nongenotoxic stresses.	Lysine	27-33	transformation related protein 53, pseudogene	Mus musculus	6-9
16943427-2	2006	Mouse p53 is acetylated at lysine 317 by PCAF and at multiple lysine residues at the extreme carboxyl terminus by CBP/p300 in response to genotoxic and some nongenotoxic stresses.	Lysine	62-68	transformation related protein 53, pseudogene	Mus musculus	6-9
16943427-3	2006	To determine the physiological roles of p53 acetylation at lysine 317, we introduced a Lys317-to-Arg (K317R) missense mutation into the endogenous p53 gene of mice.	Lysine	59-65	transformation related protein 53, pseudogene	Mus musculus	40-43
16943427-7	2006	These findings demonstrate that acetylation at lysine 317 negatively regulates p53 apoptotic activities after DNA damage.	Lysine	47-53	transformation related protein 53, pseudogene	Mus musculus	79-82
35200626-6	2022	COS also activated SIRT1 to reduce the acetylation of p65 protein at lysine 310, which was reversed by silencing SIRT1 by siRNA.	Lysine	69-75	sirtuin 1	Mus musculus	19-24
35200626-6	2022	COS also activated SIRT1 to reduce the acetylation of p65 protein at lysine 310, which was reversed by silencing SIRT1 by siRNA.	Lysine	69-75	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	54-57
35200626-6	2022	COS also activated SIRT1 to reduce the acetylation of p65 protein at lysine 310, which was reversed by silencing SIRT1 by siRNA.	Lysine	69-75	sirtuin 1	Mus musculus	113-118
30573525-3	2019	In Caenorhbditis elegans, mutations in the saccharopine dehydrogenase (SDH) domain of the bi-functional enzyme alpha-aminoadipic semialdehyde synthase AASS-1 greatly elevate the lysine catabolic intermediate saccharopine, which causes mitochondrial damage by disrupting mitochondrial dynamics, leading to reduced adult animal growth.	Lysine	178-184	aminoadipate-semialdehyde synthase	Mus musculus	71-74
16828048-3	2006	Limited proteolysis of MAB007 with Lys-C led to a single cleavage at the C-terminus of a lysine residue in the hinge region of the heavy chain at position 222, generating free Fab and Fc fragments.	Lysine	35-38	FA complementation group B	Homo sapiens	176-179
30573525-5	2019	Importantly, genetic inactivation of genes that raise the mitochondrial saccharopine precursors lysine and alpha-ketoglutarate strongly suppresses SDH mutation-induced saccharopine accumulation and mitochondrial abnormalities in C. elegans Thus, adequate saccharopine catabolism is essential for mitochondrial homeostasis.	Lysine	96-102	aminoadipate-semialdehyde synthase	Mus musculus	147-150
35058574-6	2022	Co-targeting E2F and STAT3 synergistically reduced the levels of H2AZ, histone 3 lysine 27 acetylation (H3K27ac) and cell cycle gene transcription, indicating that E2F1 and STAT3 synergize to activate H2AZ gene transcription in GSCs.	Lysine	81-87	E2F transcription factor 1	Homo sapiens	164-168
30443978-4	2019	Mass spectrometry revealed that protein sirtuin 5 (SIRT5) is a binding partner of LDHB that deacetylated LDHB at lysine-329, thereby promoting its enzymatic activity.	Lysine	113-119	lactate dehydrogenase B	Homo sapiens	82-86
35046516-7	2022	The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1, decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50, which promotes the formation of the PRMT5-Mep50 octamer.	Lysine	45-51	WD repeat domain 77	Homo sapiens	161-166
16936826-1	2006	In Saccharomyces cerevisiae, H3 methylation at lysine 4 (H3K4) is mediated by Set1.	Lysine	47-53	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	78-82
30443978-4	2019	Mass spectrometry revealed that protein sirtuin 5 (SIRT5) is a binding partner of LDHB that deacetylated LDHB at lysine-329, thereby promoting its enzymatic activity.	Lysine	113-119	lactate dehydrogenase B	Homo sapiens	105-109
16861923-9	2006	Using a set of p63 deletion mutants, we have identified a region and two critical lysine residues of p63, associated to human Split-Hand and Foot Malformation-4 (SHFM-4) syndrome, which are involved in the mechanism of Itch-mediated p63 degradation.	Lysine	82-88	tumor protein p63	Homo sapiens	15-18
16861923-9	2006	Using a set of p63 deletion mutants, we have identified a region and two critical lysine residues of p63, associated to human Split-Hand and Foot Malformation-4 (SHFM-4) syndrome, which are involved in the mechanism of Itch-mediated p63 degradation.	Lysine	82-88	tumor protein p63	Homo sapiens	101-104
16861923-9	2006	Using a set of p63 deletion mutants, we have identified a region and two critical lysine residues of p63, associated to human Split-Hand and Foot Malformation-4 (SHFM-4) syndrome, which are involved in the mechanism of Itch-mediated p63 degradation.	Lysine	82-88	tumor protein p63	Homo sapiens	101-104
35095845-3	2021	Furthermore, NAA60 possesses a unique ability of catalyzing the acetylation of membrane-anchored proteins at the N-terminus and histones at the lysine side chains.	Lysine	144-150	N-alpha-acetyltransferase 60, NatF catalytic subunit	Homo sapiens	13-18
29302794-5	2019	The deacetylation activity of Sirt3, measured as the amount of reduced acetylated lysine, was increased after stroke.	Lysine	82-88	sirtuin 3	Mus musculus	30-35
34983623-0	2022	Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-beta1/Smad3 pathway in diabetic nephropathy.	Lysine	8-14	sirtuin 3	Rattus norvegicus	76-85
35069908-0	2022	Oncogene or Tumor Suppressor: The Coordinative Role of Lysine Methyltransferase SET7/9 in Cancer Development and the Related Mechanisms.	Lysine	55-61	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	80-86
30670717-8	2019	Furthermore, chromatin immunoprecipitation revealed that methylation of histone H3 lysine 9 was correlated with repression of the Caveolin-1 promoter region.	Lysine	83-89	caveolin 1, caveolae protein	Mus musculus	130-140
35069908-1	2022	SET7/9 is a member of the protein lysine methyltransferase family that methylates both histone 3 lysine 4 (H3-K4) and lysine(s) of other non-histone proteins.	Lysine	34-40	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
35069908-1	2022	SET7/9 is a member of the protein lysine methyltransferase family that methylates both histone 3 lysine 4 (H3-K4) and lysine(s) of other non-histone proteins.	Lysine	97-103	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
35069908-1	2022	SET7/9 is a member of the protein lysine methyltransferase family that methylates both histone 3 lysine 4 (H3-K4) and lysine(s) of other non-histone proteins.	Lysine	118-124	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
16831888-1	2006	Mouse chromocenters are clusters of late-replicating pericentric heterochromatin containing HP1 bound to trimethylated lysine 9 of histone H3 (Me3K9H3).	Lysine	119-125	chromobox 5	Mus musculus	92-95
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	COP9 signalosome subunit 8	Homo sapiens	202-207
30442713-2	2019	We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.	Lysine	194-197	PHD finger protein 20-like 1	Mus musculus	163-170
16687393-12	2006	We also propose that Sir2alpha is involved in deacetylation of H2A.z, which results in ubiquitination of Lys-115 and Lys-121 and its degradation via a ubiquitin/proteasome-dependent pathway.	Lysine	105-108	H2A.Z variant histone 1	Homo sapiens	63-68
16687393-12	2006	We also propose that Sir2alpha is involved in deacetylation of H2A.z, which results in ubiquitination of Lys-115 and Lys-121 and its degradation via a ubiquitin/proteasome-dependent pathway.	Lysine	117-120	H2A.Z variant histone 1	Homo sapiens	63-68
30379096-8	2019	Moreover, SIRT1 can physically interact with HMGB1 at the deacetylated lysine sites K28, K29, and K30, subsequently suppressing downstream inflammatory signaling.	Lysine	71-77	sirtuin 1	Mus musculus	10-15
16735025-1	2006	Histone acetyltransferase 1 (HAT1) is implicated for diacetylation of Lys-5 and Lys-12 of newly synthesized histone H4, the biological significance of which remains unclear.	Lysine	70-73	histone acetyltransferase 1	Gallus gallus	0-27
16735025-1	2006	Histone acetyltransferase 1 (HAT1) is implicated for diacetylation of Lys-5 and Lys-12 of newly synthesized histone H4, the biological significance of which remains unclear.	Lysine	70-73	histone acetyltransferase 1	Gallus gallus	29-33
16735025-1	2006	Histone acetyltransferase 1 (HAT1) is implicated for diacetylation of Lys-5 and Lys-12 of newly synthesized histone H4, the biological significance of which remains unclear.	Lysine	80-83	histone acetyltransferase 1	Gallus gallus	0-27
16735025-1	2006	Histone acetyltransferase 1 (HAT1) is implicated for diacetylation of Lys-5 and Lys-12 of newly synthesized histone H4, the biological significance of which remains unclear.	Lysine	80-83	histone acetyltransferase 1	Gallus gallus	29-33
30379096-8	2019	Moreover, SIRT1 can physically interact with HMGB1 at the deacetylated lysine sites K28, K29, and K30, subsequently suppressing downstream inflammatory signaling.	Lysine	71-77	keratin 28	Mus musculus	84-87
16735025-3	2006	HAT1(-/-) cells exhibited greatly reduced diacetylation levels of Lys-5 and Lys-12, and acetylation level of Lys-5 of cytosolic and chromatin histones H4, respectively.	Lysine	66-69	histone acetyltransferase 1	Gallus gallus	0-4
16735025-3	2006	HAT1(-/-) cells exhibited greatly reduced diacetylation levels of Lys-5 and Lys-12, and acetylation level of Lys-5 of cytosolic and chromatin histones H4, respectively.	Lysine	76-79	histone acetyltransferase 1	Gallus gallus	0-4
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	cytokine like 1	Homo sapiens	24-27
16735025-3	2006	HAT1(-/-) cells exhibited greatly reduced diacetylation levels of Lys-5 and Lys-12, and acetylation level of Lys-5 of cytosolic and chromatin histones H4, respectively.	Lysine	76-79	histone acetyltransferase 1	Gallus gallus	0-4
16735025-7	2006	These results indicate that HAT1 participates in recovering replication block-mediated DNA damages, probably through chromatin modulation based on acetylation of Lys-5 and Lys-12 of histone H4.	Lysine	162-165	histone acetyltransferase 1	Gallus gallus	28-32
16735025-7	2006	These results indicate that HAT1 participates in recovering replication block-mediated DNA damages, probably through chromatin modulation based on acetylation of Lys-5 and Lys-12 of histone H4.	Lysine	172-175	histone acetyltransferase 1	Gallus gallus	28-32
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	cytokine like 1	Homo sapiens	44-47
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	cytokine like 1	Homo sapiens	44-47
16648629-3	2006	HP1(Hsalpha) possesses an amino-terminal chromodomain, which binds methylated lysine 9 of histone H3 (meK9 H3), and a carboxyl-terminal chromoshadow domain (CSD) that is required for dimerization and interaction with partner proteins.	Lysine	78-84	chromobox 5	Homo sapiens	0-12
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Lysine	132-135	cytokine like 1	Homo sapiens	44-47
16705060-6	2006	TNF-alpha treatment decreased ATGL transcript in a time-dependent manner that paralleled TNF-alpha downregulation of PPARgamma with a maximal decrease noted by 6 h. TNF-alpha effects on ATGL were attenuated by pretreatment with PD-98059, LY-294002, or rapamycin, suggesting involvement of the p44/42 MAP kinase, PI 3-kinase, and p70 ribosomal protein S6 kinase signals.	Lysine	238-240	patatin-like phospholipase domain containing 2	Mus musculus	30-34
32493764-2	2019	At the core of a highly conserved type of heterochromatin is the complex formed between chromatin methylated on histone H3 lysine 9 and HP1 proteins.	Lysine	123-129	chromobox 5	Homo sapiens	136-139
16705060-6	2006	TNF-alpha treatment decreased ATGL transcript in a time-dependent manner that paralleled TNF-alpha downregulation of PPARgamma with a maximal decrease noted by 6 h. TNF-alpha effects on ATGL were attenuated by pretreatment with PD-98059, LY-294002, or rapamycin, suggesting involvement of the p44/42 MAP kinase, PI 3-kinase, and p70 ribosomal protein S6 kinase signals.	Lysine	238-240	patatin-like phospholipase domain containing 2	Mus musculus	186-190
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	CD274 molecule	Homo sapiens	307-332
16687578-7	2006	It was proposed in the binary switch hypothesis that phosphorylation of histone H3 at Ser-10 negatively regulates the binding of HP1alpha to the adjacent methylated Lys-9.	Lysine	165-168	chromobox 5	Homo sapiens	129-137
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	CD274 molecule	Homo sapiens	334-339
16601119-10	2006	As shown by NMR measurements, no similar process occurs when poly-L-lysine is dissolved in solution with beta(2)-m.	Lysine	61-74	beta-2-microglobulin	Homo sapiens	105-114
30300608-6	2018	Extracts from mouse glomerular and non-glomerular fractions were treated with our established biotin-labeled substrate peptide, which specifically crosslinks to the lysine-donor substrates depending on TG2 activity.	Lysine	165-171	transglutaminase 2, C polypeptide	Mus musculus	202-205
16754985-1	2006	Lysine epsilon-aminotransferase (LAT) is a protein involved in lysine catabolism; it belongs to the aminotransferase family of enzymes, which use pyridoxal 5"-phosphate (PLP) as a cofactor.	Lysine	63-69	L-lysine-epsilon aminotransferase	Mycobacterium tuberculosis H37Rv	0-31
16754985-1	2006	Lysine epsilon-aminotransferase (LAT) is a protein involved in lysine catabolism; it belongs to the aminotransferase family of enzymes, which use pyridoxal 5"-phosphate (PLP) as a cofactor.	Lysine	63-69	L-lysine-epsilon aminotransferase	Mycobacterium tuberculosis H37Rv	33-36
30552140-5	2018	To discover the ubiquitination site(s) of PEPCK1, which is currently unknown, the Lys residues of PEPCK1 were mutated to Ala and the ubiquitination level of the PEPCK1 mutants was assessed.	Lysine	82-85	phosphoenolpyruvate carboxykinase 1	Homo sapiens	98-104
30552140-5	2018	To discover the ubiquitination site(s) of PEPCK1, which is currently unknown, the Lys residues of PEPCK1 were mutated to Ala and the ubiquitination level of the PEPCK1 mutants was assessed.	Lysine	82-85	phosphoenolpyruvate carboxykinase 1	Homo sapiens	98-104
16447251-2	2006	Lysine modifications are known to occur in the endoplasmic reticulum (ER) prior to collagen triple-helix formation, but in this study we show that LH3 is also present and active in the extracellular space.	Lysine	0-6	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	Mus musculus	147-150
30442762-4	2018	Ubiquitome analysis showed that loss of Lztr1 abrogated Ras ubiquitination at lysine-170.	Lysine	78-84	leucine zipper like transcription regulator 1	Homo sapiens	40-45
30510186-0	2018	MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20.	Lysine	85-91	H2B clustered histone 21	Homo sapiens	81-84
16731966-2	2006	We applied this approach to the G-protein-coupled receptor bovine rhodopsin in its native membrane using lysine- and cysteine-targeted bifunctional cross-linking reagents.	Lysine	105-111	rhodopsin	Bos taurus	66-75
30662803-7	2018	Mechanistically, SIRT5 was found to bind to and deacetylate vimentin at lysine 120.	Lysine	72-78	vimentin	Homo sapiens	60-68
16713561-2	2006	The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation.	Lysine	52-58	TNF receptor-associated factor 2	Mus musculus	91-96
16713561-2	2006	The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation.	Lysine	52-58	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	110-113
30191331-8	2018	The expression of Gls in the kidney was increased by the addition of 1.5% Arg to 3% Lys diet (P &lt; 0.05).	Lysine	84-87	glutaminase	Rattus norvegicus	18-21
16602100-2	2006	Glutaric acidemia type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism caused by deficiency of glutaryl-CoA dehydrogenase.	Lysine	70-76	glutaryl-CoA dehydrogenase	Homo sapiens	143-169
30342020-8	2018	The results suggest that acetylation of lysine 100 converts arylamine-N-acetyltransferase 1 into a switch modulated by ATP.	Lysine	40-46	N-acetyltransferase 1	Homo sapiens	60-91
16648464-3	2006	In vivo, derepression of silenced rRNA genes upon knockdown of HDA6 is accompanied by nucleolus organizer region (NOR) decondensation, loss of promoter cytosine methylation, and replacement of histone H3 Lys 9 (H3K9) dimethylation with H3K4 trimethylation, H3K9 acetylation, H3K14 acetylation, and histone H4 tetra-acetylation.	Lysine	204-207	histone deacetylase 6	Arabidopsis thaliana	63-67
16648464-4	2006	Consistent with these in vivo results, purified HDA6 deacetylates lysines modified by histone acetyltransferases whose substrates include H3K14, H4K5, and H4K12.	Lysine	66-73	histone deacetylase 6	Arabidopsis thaliana	48-52
30397335-4	2018	p63 distally closes chromatin accessibility and promotes accumulation of H3K27me3 (trimethylated histone H3 lysine 27).	Lysine	108-114	tumor protein p63	Homo sapiens	0-3
16669622-4	2006	A peptide, alpha-syn(10-48), which corresponds to the lysine-rich N-terminal region of alpha-syn, was found to associate with lipid headgroups with a preference for a negative membrane surface charge.	Lysine	54-60	synuclein alpha	Homo sapiens	11-20
16669622-4	2006	A peptide, alpha-syn(10-48), which corresponds to the lysine-rich N-terminal region of alpha-syn, was found to associate with lipid headgroups with a preference for a negative membrane surface charge.	Lysine	54-60	synuclein alpha	Homo sapiens	87-96
30479332-7	2018	Slx5-Slx8-dependent ubiquitination of Yen1 occurs mainly at K714 and mutation of this lysine increases crossover formation during DSB repair and suppresses chromosome segregation defects in a mus81  background.	Lysine	86-92	MUS81 structure-specific endonuclease subunit	Homo sapiens	192-197
16672470-5	2006	One of the analogues consisting of a replacement of both Trp and Val with Lys and Phe, respectively, resulted in a peptide with improved bactericidal activity and minimized cytotoxicity and susceptibility to protease degradation compared to Pep3.	Lysine	74-77	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	241-245
30305391-3	2018	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2, represses target genes through trimethylation of histone H3 at Lys-27 (H3K27me3), and interacts (in)directly with both protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 (NIPP1).	Lysine	187-190	protein phosphatase 1, regulatory subunit 8	Mus musculus	275-299
30305391-3	2018	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2, represses target genes through trimethylation of histone H3 at Lys-27 (H3K27me3), and interacts (in)directly with both protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 (NIPP1).	Lysine	187-190	protein phosphatase 1, regulatory subunit 8	Mus musculus	301-306
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Lysine	139-145	protein tyrosine phosphatase, receptor type, R	Mus musculus	16-21
30451821-5	2018	RORgammat is SUMO3-modified by E3 ligase PIAS4 at lysine 31 (K31), and the mutation of K31 to arginine in mice prevents RORgammat sumoylation, leading to impaired TH17 differentiation, resistance to TH17-mediated EAE, accumulation of thymic ISPs, and a lack of Peyer"s patches.	Lysine	50-56	protein inhibitor of activated STAT 4	Mus musculus	41-46
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Lysine	139-145	protein tyrosine phosphatase, receptor type, R	Mus musculus	96-101
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Lysine	139-145	protein tyrosine phosphatase, receptor type, R	Mus musculus	266-271
16441242-6	2006	The WPD loop of PTPRR was open; however, in contrast with the structure of its mouse homologue, PTPSL, a salt bridge between the conserved lysine and aspartate residues, which has been postulated to confer a more rigid loop structure, thereby modulating activity in PTPSL, does not form in PTPRR.	Lysine	139-145	protein tyrosine phosphatase, receptor type, R	Mus musculus	290-295
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	lysine methyltransferase 2A	Homo sapiens	99-103
16808171-3	2006	An immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein p53 and the cell proliferation upon the action of lysine, asparagine, and glutamic acid.	Lysine	167-173	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	117-120
30420689-7	2018	Restoring Ikaros function by Casein Kinase II inhibition also promotes ARID5B expression through recruitment of trimethylation of lysine 4 on histone H3 (H3K4me3) at its promoter region.	Lysine	130-136	AT-rich interaction domain 5B	Homo sapiens	71-77
16443603-0	2006	Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.	Lysine	120-123	microtubule associated protein tau	Homo sapiens	87-90
16443603-0	2006	Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.	Lysine	128-131	microtubule associated protein tau	Homo sapiens	87-90
16443603-0	2006	Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.	Lysine	128-131	microtubule associated protein tau	Homo sapiens	87-90
16443603-5	2006	It was found that soluble PHF-Tau is ubiquitinated at its microtubule-binding domain at residues Lys-254, Lys-311, and Lys-353, suggesting that ubiquitination of PHF-Tau may be an earlier pathological event than previously thought and that ubiquitination could play a regulatory role in modulating the integrity of microtubules during the course of AD.	Lysine	97-100	microtubule associated protein tau	Homo sapiens	26-33
16443603-5	2006	It was found that soluble PHF-Tau is ubiquitinated at its microtubule-binding domain at residues Lys-254, Lys-311, and Lys-353, suggesting that ubiquitination of PHF-Tau may be an earlier pathological event than previously thought and that ubiquitination could play a regulatory role in modulating the integrity of microtubules during the course of AD.	Lysine	106-109	microtubule associated protein tau	Homo sapiens	26-33
16443603-5	2006	It was found that soluble PHF-Tau is ubiquitinated at its microtubule-binding domain at residues Lys-254, Lys-311, and Lys-353, suggesting that ubiquitination of PHF-Tau may be an earlier pathological event than previously thought and that ubiquitination could play a regulatory role in modulating the integrity of microtubules during the course of AD.	Lysine	106-109	microtubule associated protein tau	Homo sapiens	26-33
16443603-6	2006	Tandem mass spectrometry data for ubiquitin itself indicate that PHF-Tau is modified by three polyubiquitin linkages, at Lys-6, Lys-11, and Lys-48.	Lysine	121-124	microtubule associated protein tau	Homo sapiens	65-72
30228180-7	2018	Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5).	Lysine	104-107	lysine methyltransferase 2A	Homo sapiens	59-83
16443603-6	2006	Tandem mass spectrometry data for ubiquitin itself indicate that PHF-Tau is modified by three polyubiquitin linkages, at Lys-6, Lys-11, and Lys-48.	Lysine	128-131	microtubule associated protein tau	Homo sapiens	65-72
16443603-6	2006	Tandem mass spectrometry data for ubiquitin itself indicate that PHF-Tau is modified by three polyubiquitin linkages, at Lys-6, Lys-11, and Lys-48.	Lysine	128-131	microtubule associated protein tau	Homo sapiens	65-72
30228180-7	2018	Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5).	Lysine	104-107	lysine methyltransferase 2A	Homo sapiens	85-89
16603398-2	2006	Here, we present evidence that TNFalpha induces the polyubiquitination of RIP1 at Lys-377 and that this polyubiquitination is required for the activation of IkappaB kinase (IKK) and NF-kappaB.	Lysine	82-85	receptor interacting serine/threonine kinase 1	Homo sapiens	74-78
30031905-8	2018	Furthermore, when Gata4 is knocked down, the chromatin at the RANKL region is further opened, as detected by a reduction in histone 3 lysine 27 trimethylation (H3K27me3) and an increase in histone 3 lysine 4 dimethylation (H3K4me2) in the RANKL locus.	Lysine	134-140	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	62-67
16603398-3	2006	A point mutation of RIP1 at Lys-377 (K377R) abolishes its polyubiquitination as well as its ability to restore IKK activation in a RIP1-deficient cell line.	Lysine	28-31	receptor interacting serine/threonine kinase 1	Homo sapiens	20-24
16464864-4	2006	Tau contains two SUMO consensus sequences, and mutational analyses identified Lys(340) as the major sumoylation site.	Lysine	78-81	microtubule associated protein tau	Homo sapiens	0-3
30031905-8	2018	Furthermore, when Gata4 is knocked down, the chromatin at the RANKL region is further opened, as detected by a reduction in histone 3 lysine 27 trimethylation (H3K27me3) and an increase in histone 3 lysine 4 dimethylation (H3K4me2) in the RANKL locus.	Lysine	199-205	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	62-67
30067287-4	2018	The aim of this study was to investigate the impact of the BDNF Val66Met polymorphism in the knock-in mouse model on two hippocampal epigenetic marks for transcriptional repression and activation, respectively: trimethylation of lysine 27 on histone H3 (H3K27me3) and acetylation of histone H3 (AcH3), using a genome-wide approach.	Lysine	229-235	brain derived neurotrophic factor	Mus musculus	59-63
30347783-6	2018	We have observed cross-talk between ADMA and lysine acetylation in GBM cells and platelets.	Lysine	45-51	bone morphogenetic protein receptor type 2	Homo sapiens	23-27
16567619-0	2006	NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.	Lysine	41-48	MORC family CW-type zinc finger 3	Homo sapiens	0-5
16259621-7	2006	In the present study, we have verified the ubiquitin-independent nature of TS proteolysis by showing that a "lysine-less" polypeptide, in which all lysine residues were replaced by arginine, is still subject to proteasome-mediated degradation.	Lysine	109-115	thymidylate synthetase	Homo sapiens	75-77
30190324-8	2018	In a reconstituted system in bacteria, I analyzed HSP90/P23-associated, SMYD2-mediated ERalpha methylation and found that when SMYD2 binds to the molecular chaperones, it considerably increases methylation of Lys-266 in ERalpha.	Lysine	209-212	SET and MYND domain containing 2	Homo sapiens	127-132
30304683-6	2018	Although Tnks-dependent poly-ADP-ribosylation is tightly coupled to proteolysis in the proteasome, we demonstrate that Tnks initiates degradation-independent ubiquitination on two lysine residues of JNK to promote its kinase activity and in vivo functions.	Lysine	180-186	basket	Drosophila melanogaster	199-202
16148030-3	2006	Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin suppressed both thrombin-induced VSMC DNA synthesis and migration.	Lysine	44-46	ribosomal protein S6 kinase B1	Homo sapiens	26-30
30304769-7	2018	Chromatin immunoprecipitation coupled with high-throughput sequencing for histone H3 lysine 27 (H3K27) acetylation revealed numerous putative super-enhancers near key transcription factors, including MYC, MYB, and LEF1.	Lysine	85-91	MYB proto-oncogene, transcription factor	Homo sapiens	205-208
30031038-0	2018	l-lysine (pH 6.0) induces germination of spores of Clostridium perfringens type F isolates carrying chromosomal or plasmid-borne enterotoxin gene.	Lysine	0-8	cpe	Clostridium perfringens	129-140
15976810-2	2006	Here, we report that DJ-1 was sumoylated on a lysine residue at amino-acid number 130 (K130) by PIASxalpha or PIASy.	Lysine	46-52	Parkinsonism associated deglycase	Homo sapiens	21-25
29882248-7	2018	Besides, expressions of PGK1 and PKM2 at protein and lysine, succinylation levels are significantly altered in RCC tissues.	Lysine	53-59	phosphoglycerate kinase 1	Homo sapiens	24-28
16320010-3	2006	In particular, the H39K mutation inserts a lysine at position 39 as in the sequence of equine cytochrome c.	Lysine	43-49	cytochrome c, somatic	Equus caballus	94-106
29882248-7	2018	Besides, expressions of PGK1 and PKM2 at protein and lysine, succinylation levels are significantly altered in RCC tissues.	Lysine	53-59	pyruvate kinase M1/2	Homo sapiens	33-37
29802959-8	2018	Site-specific, covalent modifications of apoA-I (lysines or arginines) led to altered protein structure, reduced lipid binding capability and a reduced ability to catalyze cholesterol efflux from macrophages, partly in a modification-specific manner.	Lysine	49-56	apolipoprotein A1	Rattus norvegicus	41-47
17071716-4	2006	Notably, we observe pronounced tilting of the axis of dsDNA with respect to the PCNA ring plane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine and lysine residues lining the PCNA inner surface.	Lysine	196-202	proliferating cell nuclear antigen	Homo sapiens	80-84
17071716-4	2006	Notably, we observe pronounced tilting of the axis of dsDNA with respect to the PCNA ring plane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine and lysine residues lining the PCNA inner surface.	Lysine	196-202	proliferating cell nuclear antigen	Homo sapiens	223-227
30060157-5	2018	Our results show that GDF9 + BMP15 through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of histone 3 lysine 27 (H3K27ac), facilitating AMH/Amh expression.	Lysine	188-194	anti-Mullerian hormone	Homo sapiens	129-132
16222244-3	2005	For example, heterochromatin protein 1 (HP1) binds to histone H3 when its lysine 9 residue has been tri-methylated by the methyltransferase Suv39h (refs 2-6).	Lysine	74-80	chromobox 5	Homo sapiens	13-38
16222244-3	2005	For example, heterochromatin protein 1 (HP1) binds to histone H3 when its lysine 9 residue has been tri-methylated by the methyltransferase Suv39h (refs 2-6).	Lysine	74-80	chromobox 5	Homo sapiens	40-43
16222246-1	2005	Tri-methylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1 (HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin packaging and heterochromatin formation.	Lysine	30-36	chromobox 5	Homo sapiens	67-92
16222246-1	2005	Tri-methylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1 (HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin packaging and heterochromatin formation.	Lysine	30-36	chromobox 5	Homo sapiens	94-97
16222246-2	2005	Here we show that HP1alpha, -beta, and -gamma are released from chromatin during the M phase of the cell cycle, even though tri-methylation levels of histone H3 lysine 9 remain unchanged.	Lysine	161-167	chromobox 5	Homo sapiens	18-45
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	126-132	structural maintenance of chromosomes 1B	Mus musculus	30-38
29913563-2	2018	The phenotype of Hint2 knockout ( Hint2-/-) mice includes progressive hepatic steatosis and lysine hyperacetylation of mitochondrial proteins, which are features of respiratory chain malfunctions.	Lysine	92-98	histidine triad nucleotide binding protein 2	Mus musculus	17-22
16236716-7	2005	Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27.	Lysine	139-145	structural maintenance of chromosomes 1B	Mus musculus	30-38
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	149-155	transformation related protein 53	Mus musculus	32-35
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	149-155	transformation related protein 73	Mus musculus	40-43
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	196-202	transformation related protein 53	Mus musculus	32-35
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	196-202	transformation related protein 73	Mus musculus	40-43
16203738-8	2005	However, chromatin-bound TA-p73 is associated with elevated di- and tri-methylated histone H3 lysine 4 levels in p53-null liver and hepatoma cells, concomitant with a reduced ability to repress transcription compared with p53.	Lysine	94-100	transformation related protein 73	Mus musculus	25-31
29913563-2	2018	The phenotype of Hint2 knockout ( Hint2-/-) mice includes progressive hepatic steatosis and lysine hyperacetylation of mitochondrial proteins, which are features of respiratory chain malfunctions.	Lysine	92-98	histidine triad nucleotide binding protein 2	Mus musculus	34-39
29851245-7	2018	NEDD4 interacted with the C-terminal region and ubiquitinated the N-terminal lysine 88 in PIP5Kalpha.	Lysine	77-83	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5
30014449-3	2018	As KMT2A is known to regulate the expression of multiple target genes through methylation of lysine 4 of histone 3 (H3K4me), we sought to investigate the transcriptomic consequences of KMT2A variants involved in WSS.	Lysine	93-99	lysine methyltransferase 2A	Homo sapiens	3-8
16179989-3	2005	Knocking down the key regulator of dosage compensation, male-specific-lethal 2 (MSL2), leads to loss of propagation of histone H4 lysine 16 acetylation and of the twofold elevation of transcription characteristic of the compensated male X chromosome.	Lysine	130-136	male-specific lethal 2	Drosophila melanogaster	56-78
16179989-3	2005	Knocking down the key regulator of dosage compensation, male-specific-lethal 2 (MSL2), leads to loss of propagation of histone H4 lysine 16 acetylation and of the twofold elevation of transcription characteristic of the compensated male X chromosome.	Lysine	130-136	male-specific lethal 2	Drosophila melanogaster	80-84
30006344-5	2018	Using a search approach based on the Batch Tag program, we identified cross-linked peptides and found that these chemically activated lysines reacted with acidic amino acid residues creating gamma-glutamyl-epsilon-lysine or aspartyl-epsilon-lysine isopeptide bonds between beta- and alpha-tubulin.	Lysine	134-141	tubulin alpha 1b	Homo sapiens	273-296
16120648-3	2005	Our results further show that human ADAR1 is modified by SUMO-1 on lysine residue 418.	Lysine	67-73	adenosine deaminase RNA specific	Homo sapiens	36-41
16185711-1	2005	The yeast Set1-complex catalyzes histone H3 lysine 4 (H3K4) methylation.	Lysine	44-50	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	10-14
30150770-4	2018	Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS.	Lysine	84-90	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	58-62
16007161-3	2005	Based on the differential effects of HBx natural variants, we determined that Lys-130 in the transactivation domain of HBx is critical for the E-cadherin repression.	Lysine	78-81	X protein	Hepatitis B virus	37-40
16007161-3	2005	Based on the differential effects of HBx natural variants, we determined that Lys-130 in the transactivation domain of HBx is critical for the E-cadherin repression.	Lysine	78-81	X protein	Hepatitis B virus	119-122
30150770-4	2018	Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS.	Lysine	146-152	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	58-62
29959229-5	2018	We show that Rpl29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1 (also known as Kdm1a).	Lysine	19-25	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	67-73
15937953-6	2005	TEM results and structural analysis indicate that the drop of infectivity as the PEG concentration is increased beyond the critical conjugation ratio may be due to a combination of steric interference with viral regions necessary for infection as well as reaction at important lysine residues.	Lysine	277-283	progestagen associated endometrial protein	Homo sapiens	81-84
30089812-3	2018	Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation.	Lysine	100-106	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	6-25
15937148-7	2005	Pre-exposure of SG neurons to the ORL1 receptor blocker, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101), significantly decreased the Noc-mediated Ca(2+) current inhibition.	Lysine	74-77	prepronociceptin	Rattus norvegicus	133-136
30089812-3	2018	Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation.	Lysine	100-106	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	27-30
15890677-3	2005	In this report, we show that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of Foxo1 in vivo and in vitro, and potently stimulates Foxo1-induced transcription of IGF-binding protein-1 in transient transfection experiments.	Lysine	70-77	insulin like growth factor binding protein 1	Homo sapiens	196-217
30089812-3	2018	Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation.	Lysine	100-106	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	31-36
29756317-3	2018	Both the internal PLP aldimine (PLP-LYS) and the external PLP aldimine (PLP-SER) of SHMT are found to have a higher stability for the ketoenamine tautomer over the enolimine form.	Lysine	36-39	serine hydroxymethyltransferase 1	Homo sapiens	84-88
16135811-5	2005	Strikingly, the dramatic loss of acetylation of the K9 and K14 lysine residues of histone H3 in dGcn5 mutants has no noticeable effect on larval tissues.	Lysine	63-69	Gcn5 acetyltransferase	Drosophila melanogaster	96-101
29608813-9	2018	Mechanistically, I101T reduced the protein half-life of PTEN possibly due to enhanced polyubiquitination at Lysine 13.	Lysine	108-114	phosphatase and tensin homolog	Homo sapiens	56-60
16170020-2	2005	Transglutaminase 2 promotes transamidation between glutamine and lysine residues with the formation of covalent linkages between proteins.	Lysine	65-71	transglutaminase 2, C polypeptide	Mus musculus	0-18
16229802-5	2005	In this report, we show that in normal cells expressing 14-3-3sigma, the 14-3-3sigma CpG island is unmethylated; associated with acetylated histones, unmethylated histone H3 lysine 9; and an accessible chromatin structure.	Lysine	174-180	stratifin	Homo sapiens	56-67
29679476-4	2018	Among the eight different homotypic chain types, Met1-linked (also termed linear) chains are the only chains in which linkage occurs on a non-Lys residue of ubiquitin.	Lysine	142-145	granzyme M	Homo sapiens	49-53
16229802-5	2005	In this report, we show that in normal cells expressing 14-3-3sigma, the 14-3-3sigma CpG island is unmethylated; associated with acetylated histones, unmethylated histone H3 lysine 9; and an accessible chromatin structure.	Lysine	174-180	stratifin	Homo sapiens	73-84
29875242-7	2018	We also demonstrate that EML1 and EML3 bind peptides containing histone H3 lysine 36 (H3K36), a PTM usually associated with active gene expression.	Lysine	75-81	EMAP like 1	Homo sapiens	25-29
16268459-3	2005	The knowledge that proCPU can be activated by thrombin and plasmin, enzymes with a key function in coagulation and fibrinolysis, and the ability of CPU to remove C-terminal lysine residues has led to the hypothesis that the proCPU/CPU pathway plays a role in the balance between coagulation and fibrinolysis.	Lysine	173-179	carboxypeptidase B2 (plasma)	Mus musculus	22-25
16268459-3	2005	The knowledge that proCPU can be activated by thrombin and plasmin, enzymes with a key function in coagulation and fibrinolysis, and the ability of CPU to remove C-terminal lysine residues has led to the hypothesis that the proCPU/CPU pathway plays a role in the balance between coagulation and fibrinolysis.	Lysine	173-179	carboxypeptidase B2 (plasma)	Mus musculus	148-151
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	312-315	sirtuin 2	Homo sapiens	252-282
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	sirtuin 2	Homo sapiens	252-282
16076959-2	2005	We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent histone deacetylase silent information regulator 2, and that the acetylation at Lys-242, Lys-245, and Lys-262 of Foxo1 attenuates its transcriptional activity.	Lysine	321-324	sirtuin 2	Homo sapiens	252-282
29875242-7	2018	We also demonstrate that EML1 and EML3 bind peptides containing histone H3 lysine 36 (H3K36), a PTM usually associated with active gene expression.	Lysine	75-81	EMAP like 3	Homo sapiens	34-38
30094379-5	2018	We present evidence that SUMOylation of Glis3 by PIAS-family proteins occurs at two conserved lysine residues within the Glis3 N-terminus and modification of Glis3 by SUMO dramatically inhibited insulin transcription.	Lysine	94-100	GLIS family zinc finger 3	Homo sapiens	40-45
30094379-5	2018	We present evidence that SUMOylation of Glis3 by PIAS-family proteins occurs at two conserved lysine residues within the Glis3 N-terminus and modification of Glis3 by SUMO dramatically inhibited insulin transcription.	Lysine	94-100	GLIS family zinc finger 3	Homo sapiens	121-126
29789424-8	2018	We found that the C-terminal 20-amino acid-long region of Jen1 contains an amino acid sequence required for association of Jen1 to the alpha-arrestin Rod1, as well as lysine residues important for glucose-induced Jen1 ubiquitination.	Lysine	167-173	Jen1p	Saccharomyces cerevisiae S288C	58-62
15813706-2	2005	The positively charged lysine-rich fifth domain of beta2GPI facilitates its interaction with phospholipid membranes containing acidic phospholipids, which normally become exposed by apoptotic processes.	Lysine	23-29	apolipoprotein H	Homo sapiens	51-59
16002700-10	2005	Functional analysis indicated that Lys(68) and Glu(70) in the extracellular domain of h2B4 play a key role in the activation of human NK cells through 2B4/CD48 interaction.	Lysine	35-38	CD244 molecule	Homo sapiens	86-90
16002700-10	2005	Functional analysis indicated that Lys(68) and Glu(70) in the extracellular domain of h2B4 play a key role in the activation of human NK cells through 2B4/CD48 interaction.	Lysine	35-38	CD244 molecule	Homo sapiens	87-90
30002377-3	2018	Our results show that three loops from TIRR interact with 53BP1 TTD and mask the methylated lysine-binding pocket in TTD.	Lysine	92-98	tumor protein p53 binding protein 1	Homo sapiens	58-63
15951486-2	2005	DHS mediates the first of two sequential enzymatic reactions that activate eukaryotic translation initiation factor-5A (eIF-5A) by converting a conserved Lys to the unusual amino acid, deoxyhypusine.	Lysine	154-157	deoxyhypusine synthase	Solanum lycopersicum	0-3
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Lysine	201-204	sucrase-isomaltase	Homo sapiens	29-46
15994556-5	2005	Here, we found that MIR1, but not MIR2, promoted down-regulation of MHC I molecules lacking lysine residues in their intracytoplasmic domain.	Lysine	92-98	fibronectin type III and SPRY domain containing 1	Homo sapiens	20-24
15910735-0	2005	Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1.	Lysine	12-18	alpha-2-macroglobulin	Homo sapiens	45-65
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	45-48	alpha-2-macroglobulin	Homo sapiens	3-10
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	45-48	alpha-2-macroglobulin	Homo sapiens	175-182
29707871-1	2018	This study was conducted to test our hypothesis that intramuscular fat (IMF) accumulation increases in pigs fed on a low lysine diet during the dark period than those fed on the same diet during the light period.	Lysine	121-127	IMF	Sus scrofa	72-75
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	59-62	alpha-2-macroglobulin	Homo sapiens	3-10
15910735-2	2005	In alpha2M fragments, expressed in bacteria, Lys(1370) and Lys(1374) are critical for binding to the low density lipoprotein receptor-related protein-1 (LRP-1) and a distinct alpha2M-signaling receptor.	Lysine	59-62	alpha-2-macroglobulin	Homo sapiens	175-182
15910735-6	2005	Mutation of Lys(1370) almost entirely inhibited specific binding of methylamine-activated r(alpha)2M to RAW 264.7 cells.	Lysine	12-15	alpha-2-macroglobulin	Homo sapiens	90-100
29663531-0	2018	Identification of variants in the mitochondrial lysine-tRNA (MT-TK) gene in myoclonic epilepsy-pathogenicity evaluation and structural characterization by in silico approach.	Lysine	48-54	mitochondrially encoded tRNA lysine	Homo sapiens	61-66
15899873-5	2005	While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region.	Lysine	232-238	cytokine inducible SH2 containing protein	Homo sapiens	93-97
29967538-3	2018	53BP1 is recruited to DSBs by recognizing histone lysine methylation within chromatin, an activity directly inhibited by the 53BP1-binding protein TIRR.	Lysine	50-56	tumor protein p53 binding protein 1	Homo sapiens	0-5
15774468-8	2005	The results define the structural basis for the unusual binding pattern of the PICK1 PDZ domain by substantiating the critical role of the alphaB1 position (Lys(83)) and of discrete side chain differences in position P(0) of the ligands.	Lysine	157-160	protein interacting with PRKCA 1	Homo sapiens	79-84
15749714-1	2005	Human Ubc13 and Mms2 (or its homolog, Uev1) form a unique ubiquitin-conjugating enzyme (Ubc) complex that generates atypical Lys(63)-linked ubiquitin conjugates.	Lysine	125-128	ubiquitin conjugating enzyme E2 N	Homo sapiens	6-11
15749714-1	2005	Human Ubc13 and Mms2 (or its homolog, Uev1) form a unique ubiquitin-conjugating enzyme (Ubc) complex that generates atypical Lys(63)-linked ubiquitin conjugates.	Lysine	125-128	ubiquitin conjugating enzyme E2 V2	Homo sapiens	16-20
15749714-1	2005	Human Ubc13 and Mms2 (or its homolog, Uev1) form a unique ubiquitin-conjugating enzyme (Ubc) complex that generates atypical Lys(63)-linked ubiquitin conjugates.	Lysine	125-128	ubiquitin conjugating enzyme E2 V1	Homo sapiens	38-42
15749714-4	2005	Substantial biochemical evidence has revealed a mechanism whereby Mms2 properly orients ubiquitin to allow for Lys(63) conjugation by Ubc13; however, how this specific Ubc13-Mms2 complex is formed and why Mms2 does not form a complex with other Ubcs have not been reported.	Lysine	111-114	ubiquitin conjugating enzyme E2 V2	Homo sapiens	66-70
29967538-3	2018	53BP1 is recruited to DSBs by recognizing histone lysine methylation within chromatin, an activity directly inhibited by the 53BP1-binding protein TIRR.	Lysine	50-56	tumor protein p53 binding protein 1	Homo sapiens	125-130
29718430-15	2018	Plasma Lys, Met, Thr, and Trp of +LPS steers were lower than -LPS steers at 4 (Thr only), 8 (Lys and Trp only), 12, and 24 h after infusion (LPS x h, P &lt; 0.05).	Lysine	7-10	interferon regulatory factor 6	Homo sapiens	34-37
15914356-4	2005	Recent studies have revealed that MLL assembles, as do some trxG proteins, into a chromatin-modifying transcriptional regulatory supercomplex to regulate epigenetic pathways, including the methylation of histone H3 lysine 4, which is conferred by the Su (var)3-9, enhancer of zeste, and tritho-rax (SET) domain.	Lysine	215-221	lysine methyltransferase 2A	Homo sapiens	34-37
29943287-8	2018	Modification of the lysine of SP decreases the binding affinity of the peptide to the NK1 receptor.	Lysine	20-26	tachykinin receptor 1	Homo sapiens	86-98
29603287-5	2018	Lysine 1667 is essential for interaction with importin and its substitution to arginine reduced nuclear localisation of 53BP1.	Lysine	0-6	tumor protein p53 binding protein 1	Homo sapiens	120-125
15805117-4	2005	Mutation analysis suggests that the Arg-5 and Lys-110 residues on the PCNA back side are the contact points of the two homotrimers in the doublet.	Lysine	46-49	proliferating cell nuclear antigen	Homo sapiens	70-74
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	early growth response 1	Homo sapiens	323-328
29604308-6	2018	Finally, we found that the Lys-372 residue of TRIM50, critical for its own acetylation, is necessary for its E3 ligase activity that governs Beclin1 ubiquitination.	Lysine	27-30	tripartite motif containing 50	Homo sapiens	46-52
15766269-0	2005	Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.	Lysine	56-62	beta-2-microglobulin	Homo sapiens	74-94
29401608-12	2018	Finally, we found that lysine 410 is a key SUMOylated residue contributing to CYP2E1 protein stability and activity preventing CYP2E1 SUMOylation.	Lysine	23-29	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	78-84
15752042-4	2005	For mCDNPc"s in which the modified lysine residue is outside of the interaction domain of cyt c with the SAM, the ratio of the k(et) of mCDNPc to that of native cyt c is correlated to the change in the dipole moment vector of cyt c due to the CDNP modification.	Lysine	35-41	cytochrome c, somatic	Equus caballus	161-166
15752042-4	2005	For mCDNPc"s in which the modified lysine residue is outside of the interaction domain of cyt c with the SAM, the ratio of the k(et) of mCDNPc to that of native cyt c is correlated to the change in the dipole moment vector of cyt c due to the CDNP modification.	Lysine	35-41	cytochrome c, somatic	Equus caballus	161-166
29401608-12	2018	Finally, we found that lysine 410 is a key SUMOylated residue contributing to CYP2E1 protein stability and activity preventing CYP2E1 SUMOylation.	Lysine	23-29	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	127-133
15487984-11	2005	Natural human DPPII showed high efficiency towards synthetic substrates containing proline at the P1 position and lysine at P2.	Lysine	114-120	dipeptidyl peptidase 7	Homo sapiens	14-19
29685391-1	2018	Heterochromatin protein 1 (HP1), associated with heterochromatin formation, recognizes an epigenetically repressive marker, trimethylated lysine 9 in histone H3 (H3K9me3), and generally contributes to long-term silencing.	Lysine	138-144	chromobox 5	Homo sapiens	0-25
15713636-3	2005	In this study, we show that an intergenic cis-acting element in the mouse lambda5-VpreB1 locus is marked by histone H3 acetylation and histone H3 lysine 4 methylation at a discrete site in embryonic stem (ES) cells.	Lysine	146-152	pre-B lymphocyte gene 1	Mus musculus	82-88
29685391-1	2018	Heterochromatin protein 1 (HP1), associated with heterochromatin formation, recognizes an epigenetically repressive marker, trimethylated lysine 9 in histone H3 (H3K9me3), and generally contributes to long-term silencing.	Lysine	138-144	chromobox 5	Homo sapiens	27-30
29754817-4	2018	Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively.	Lysine	41-47	b-associated fitness	Mus musculus	116-128
15546877-5	2005	Replacement of the conserved lysine residue within the Walker A motif with alanine, glutamate, or arginine results in the same DNA damage sensitivity and homologous recombination defect as the rad50 deletion mutation.	Lysine	29-35	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	193-198
28540657-5	2018	By reducing the production of lysine (K63)-linked ubiquitin chains, UCH-L1 inhibition decreases HDAC6 deacetylase activity and attenuates the interaction of HDAC6 and tau protein, finally leading to tau aggresome formation impairment.	Lysine	30-36	ubiquitin C-terminal hydrolase L1	Homo sapiens	68-74
15582604-1	2005	MysPDZ is an unconventional myosin belonging to the class XVIII myosin containing a KE (lysine and glutamine)-rich domain and a PDZ domain, which codistributes with actin fibers partially without any canonical actin binding sequence in its myosin head domain.	Lysine	88-94	myosin XVIIIA	Homo sapiens	0-6
29393594-0	2018	The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position.	Lysine	59-65	major histocompatibility complex, class I, B	Homo sapiens	26-33
15516695-9	2005	On the other hand, Lys(149) is close to a cluster of acidic amino acids near the FMN binding site of CPR.	Lysine	19-22	formin 1	Homo sapiens	81-84
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	6-9	formin 1	Homo sapiens	137-140
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	6-9	heme oxygenase 1	Homo sapiens	159-163
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	19-22	formin 1	Homo sapiens	137-140
15516695-10	2005	Thus, Lys(149) and Lys(153) appear to interact with CPR in such a way as to orient the redox partners for optimal electron transfer from FMN of CPR to heme of HO-1.	Lysine	19-22	heme oxygenase 1	Homo sapiens	159-163
29393594-5	2018	The results indicate that C67S mutation increases the percentage of peptides with glutamine or lysine at their P2 position (P2-Lys), in both HLA-B*27:05 and HLA-B*27:09.	Lysine	95-101	major histocompatibility complex, class I, B	Homo sapiens	141-146
29393594-5	2018	The results indicate that C67S mutation increases the percentage of peptides with glutamine or lysine at their P2 position (P2-Lys), in both HLA-B*27:05 and HLA-B*27:09.	Lysine	95-101	major histocompatibility complex, class I, B	Homo sapiens	157-162
29393594-5	2018	The results indicate that C67S mutation increases the percentage of peptides with glutamine or lysine at their P2 position (P2-Lys), in both HLA-B*27:05 and HLA-B*27:09.	Lysine	127-130	major histocompatibility complex, class I, B	Homo sapiens	141-146
29393594-5	2018	The results indicate that C67S mutation increases the percentage of peptides with glutamine or lysine at their P2 position (P2-Lys), in both HLA-B*27:05 and HLA-B*27:09.	Lysine	127-130	major histocompatibility complex, class I, B	Homo sapiens	157-162
29393594-6	2018	Furthermore, a small fraction of HLA-B*27 peptides contains lysine at their second position (P2), in addition to the more commonly found peptides with arginine (P2-Arg) or the less common glutamine (P2-Gln) located at this anchor position.	Lysine	60-66	major histocompatibility complex, class I, B	Homo sapiens	33-38
29511085-10	2018	Amino acid sequence alignments of SALL family members indicated that the region around SALL4 Lys-190 is conserved in both SALL1 and SALL3.	Lysine	93-96	spalt like transcription factor 3	Homo sapiens	132-137
16508077-2	2005	The crystal structure of a triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2 in which the lysine residues at positions 53, 56 and 121 are replaced recombinantly by methionines has been determined at atomic resolution (0.97 A).	Lysine	106-112	LOC104974671	Bos taurus	76-92
15921168-0	2005	Hb Kurosaki [alpha7(A5)Lys -->Glu (AAG --> GAG)]: an alpha2-globin gene mutation found in Thailand.	Lysine	23-26	immunoglobulin kappa variable 2D-26	Homo sapiens	0-22
15921168-1	2005	Hb Kurosaki [alpha 7(A5)Lys --> Glu (AAG --> GAG)], has been found for the first time in Thailand.	Lysine	24-27	immunoglobulin kappa variable 2D-26	Homo sapiens	0-23
29555846-10	2018	The major SUMO acceptor lysines are different and are localized in nonconserved sequences among CoREST proteins.	Lysine	24-31	REST corepressor 1	Homo sapiens	96-102
29765542-4	2018	However, substitution mutation (Arginine and Lysine to Alanine) in the D-box elements of SMAR1 viz.	Lysine	45-51	BTG3 associated nuclear protein	Mus musculus	89-94
15595847-1	2004	Human proliferating cell nuclear antigen (hPCNA) containing a single amino acid substitution at position 85, that of lysine for glutamate (E85K), was compared to wild-type (wt) hPCNA for its ability to promote DNA synthesis by purified DNA polymerase delta (pol delta) both on unmodified templates and past chemically defined template base lesions (translesion synthesis; TLS).	Lysine	117-123	proliferating cell nuclear antigen	Homo sapiens	6-40
15595847-3	2004	These results suggest that human PCNA, either mutated to contain lysine (K) at position 85 or bearing similar primary mutations, would promote more secondary mutagenesis in cells and/or tissues where PCNA is normally expressed at low levels relative to pol delta.	Lysine	65-71	proliferating cell nuclear antigen	Homo sapiens	33-37
15595847-3	2004	These results suggest that human PCNA, either mutated to contain lysine (K) at position 85 or bearing similar primary mutations, would promote more secondary mutagenesis in cells and/or tissues where PCNA is normally expressed at low levels relative to pol delta.	Lysine	65-71	proliferating cell nuclear antigen	Homo sapiens	200-204
29642005-5	2018	We find that MIB2 represses the cytotoxic potential of RIPK1 by ubiquitylating lysine residues in the C-terminal portion of RIPK1.	Lysine	79-85	receptor interacting serine/threonine kinase 1	Homo sapiens	55-60
15465811-8	2004	Interaction with UbcH13 suggests a possible role for K3 in catalyzing Lys(63)-linked ubiquitination.	Lysine	70-73	ubiquitin conjugating enzyme E2 N	Homo sapiens	17-23
15571399-2	2004	Using helices containing a pair of the iminodiacetic acid derivatives of lysine (Ida), we show that metal-induced helix destabilization is a promising approach to functional switching, especially for helices that are intrinsically stable.	Lysine	73-79	alpha-L-iduronidase	Homo sapiens	81-84
29642005-5	2018	We find that MIB2 represses the cytotoxic potential of RIPK1 by ubiquitylating lysine residues in the C-terminal portion of RIPK1.	Lysine	79-85	receptor interacting serine/threonine kinase 1	Homo sapiens	124-129
29642005-7	2018	Disruption of MIB2-mediated ubiquitylation, either by mutation of MIB2"s E3 activity or RIPK1"s ubiquitin-acceptor lysines, sensitizes cells to RIPK1-mediated cell death.	Lysine	115-122	receptor interacting serine/threonine kinase 1	Homo sapiens	88-93
29581290-1	2018	The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport.	Lysine	12-18	serine/threonine kinase 24	Homo sapiens	50-55
15542849-6	2004	Finally, we have located a key lysine residue that is both a substrate for CBP acetylation and required for Sin3A interaction.	Lysine	31-37	SIN3 transcription regulator family member A	Homo sapiens	108-113
15368120-9	2004	N-terminal sequence analysis of a 17-kDa polypeptide revealed the isolation of a C-terminal fragment of IGFBP-3 starting with Lys 160.	Lysine	126-129	insulin like growth factor binding protein 3	Homo sapiens	104-111
29440272-5	2018	Demonstrating now that iNOS expression in photostressed U87 cells is mediated by NF-kappaB, we hypothesized that (i) recognition of acetylated lysine (acK) on NF-kappaB p65/RelA by bromodomain and extra-terminal (BET) protein Brd4 is crucial; and (ii) by suppressing iNOS expression, a BET inhibitor (JQ1) would attenuate the negative effects of photostress.	Lysine	143-149	tyrosine kinase non receptor 2	Homo sapiens	151-154
18404400-0	2004	Conserved lysine 79 is important for activity of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Lysine	10-16	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	49-98
18404400-0	2004	Conserved lysine 79 is important for activity of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Lysine	10-16	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	100-108
18404400-2	2004	In this study, we mutated lysine 79 in human ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Lysine	26-32	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	45-94
29462789-6	2018	hFEN1 residues with distinct roles in the catalytic mechanism, including those binding metal ions (Asp-34 and Asp-181), steering the 5"-flap through the active site and binding the scissile phosphate (Lys-93 and Arg-100), and stacking against the base 5" to the scissile phosphate (Tyr-40), all contribute to these rate-limiting conformational changes, ensuring efficient and specific cleavage of 5"-flaps.	Lysine	201-204	flap structure-specific endonuclease 1	Homo sapiens	0-5
18404400-2	2004	In this study, we mutated lysine 79 in human ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3).	Lysine	26-32	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	96-104
18404400-3	2004	The residue corresponding to lysine 79 in NTPDase3 is conserved in all known cell surface membrane NTPDases (NTPDase1, 2, 3, and 8), but not in the soluble, monomeric NTPDases (NTPDase5 and 6), or in the intracellular, two transmembrane NTPDases (NTPDase4 and 7).	Lysine	29-35	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	42-50
18404400-3	2004	The residue corresponding to lysine 79 in NTPDase3 is conserved in all known cell surface membrane NTPDases (NTPDase1, 2, 3, and 8), but not in the soluble, monomeric NTPDases (NTPDase5 and 6), or in the intracellular, two transmembrane NTPDases (NTPDase4 and 7).	Lysine	29-35	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	109-130
18404400-3	2004	The residue corresponding to lysine 79 in NTPDase3 is conserved in all known cell surface membrane NTPDases (NTPDase1, 2, 3, and 8), but not in the soluble, monomeric NTPDases (NTPDase5 and 6), or in the intracellular, two transmembrane NTPDases (NTPDase4 and 7).	Lysine	29-35	ectonucleoside triphosphate diphosphohydrolase 5 (inactive)	Homo sapiens	177-185
29593216-5	2018	Klf4 polyglutamylation at Glu381 by tubulin tyrosine ligase-like 4 (TTLL4) and TTLL1 during cell reprogramming impedes its lysine 48-linked ubiquitination and sustains Klf4 stability.	Lysine	123-129	tubulin tyrosine ligase-like 1	Mus musculus	79-84
15493016-4	2004	Interestingly, Eed associates with Ezh2 to form a complex possessing histone methyltransferase activity predominantly for H3 Lys-27.	Lysine	125-128	embryonic ectoderm development	Mus musculus	15-18
29336543-2	2018	Here, we report in vitro profiling of HDAC11 deacylase activities, and our data unequivocally show that the enzyme efficiently removes acyl moieties spanning 8-18 carbons from the side chain nitrogen of the lysine residue of a peptidic substrate.	Lysine	207-213	histone deacetylase 11	Homo sapiens	38-44
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	AGBL carboxypeptidase 2	Homo sapiens	169-173
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	AGBL carboxypeptidase 2	Homo sapiens	169-173
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Lysine	207-210	AGBL carboxypeptidase 2	Homo sapiens	169-173
29547723-6	2018	CIPK23-driven phosphorylation and IDF1-mediated lysine-63 polyubiquitination are jointly required for efficient endosomal sorting and vacuolar degradation of IRT1.	Lysine	48-54	allograft inflammatory factor 1	Homo sapiens	158-162
15121739-5	2004	FGF-1-induced PN expression was blocked by the FGF-1 receptor antagonist PD-166866 and by inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY-294002, wortmannin), p70S6K (rapamycin), MEK1/2 (U-0126, PD-98059), and p38MAPK (SB-203580) but not of JNK (SP-600125).	Lysine	142-144	ribosomal protein S6 kinase B1	Rattus norvegicus	166-172
15121739-5	2004	FGF-1-induced PN expression was blocked by the FGF-1 receptor antagonist PD-166866 and by inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY-294002, wortmannin), p70S6K (rapamycin), MEK1/2 (U-0126, PD-98059), and p38MAPK (SB-203580) but not of JNK (SP-600125).	Lysine	142-144	mitogen-activated protein kinase 8	Rattus norvegicus	248-251
29721150-6	2018	Sirt3 modulates age-associated mitochondrial biology and function via lysine deacetylation of target proteins, and we show that its regulation depends on its nitration status and is benefited by the improved NAD+/NADH ratio in aged p66Shc(-/-) brain mitochondria.	Lysine	70-76	sirtuin 3	Mus musculus	0-5
15377274-5	2004	Analysis by LC/MSD-Trap showed the amino acid sequence of this hexapeptide to be Glu-Ala-Lys-Ser-Gln-Gly-OH with molecular weight 618.5 daltons.	Lysine	89-92	acid phosphatase 5, tartrate resistant	Bos taurus	19-23
15231023-6	2004	Recently, we proposed that LH2 might modulate collagen cross-linking pattern through its action on Lys residues located in the telopeptide domains of collagen.	Lysine	99-102	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	27-30
29358331-6	2018	Our studies further revealed that PHF20L1 binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis.	Lysine	68-71	PHD finger protein 20 like 1	Homo sapiens	34-41
15258579-0	2004	B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.	Lysine	34-40	paired box 5	Mus musculus	84-88
29358331-6	2018	Our studies further revealed that PHF20L1 binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis.	Lysine	79-82	PHD finger protein 20 like 1	Homo sapiens	34-41
29127188-4	2018	The reduction in Ahcy expression was associated with gene-specific cytosine DNA hypermethylation and enrichment of the gene promoter by trimethylated histone H3 lysine 27 and deacetylated histone H4 lysine 16, 2 main transcription-inhibiting markers.	Lysine	161-167	adenosylhomocysteinase	Homo sapiens	17-21
15131131-1	2004	Mutational studies of T cell receptor (TCR) contact residues on the surface of the human class I major histocompatibility complex (MHC) molecule HLA-A2 have identified a "functional hot spot" that comprises Arg(65) and Lys(66) and is involved in recognition by most peptide-specific HLA-A2-restricted TCRs.	Lysine	219-222	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	22-37
15131131-1	2004	Mutational studies of T cell receptor (TCR) contact residues on the surface of the human class I major histocompatibility complex (MHC) molecule HLA-A2 have identified a "functional hot spot" that comprises Arg(65) and Lys(66) and is involved in recognition by most peptide-specific HLA-A2-restricted TCRs.	Lysine	219-222	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	39-42
15131131-6	2004	However, these effects are independent of their effects on TCR recognition, and the Arg(65)-Lys(66) region thus represents a true "hot spot" for TCR recognition.	Lysine	92-95	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	145-148
15138260-4	2004	The p300-dependent acetylation of three lysine residues protects RUNX3 from ubiquitin ligase Smurf-mediated degradation.	Lysine	40-46	RUNX family transcription factor 3	Homo sapiens	65-70
29127188-4	2018	The reduction in Ahcy expression was associated with gene-specific cytosine DNA hypermethylation and enrichment of the gene promoter by trimethylated histone H3 lysine 27 and deacetylated histone H4 lysine 16, 2 main transcription-inhibiting markers.	Lysine	199-205	adenosylhomocysteinase	Homo sapiens	17-21
29330289-7	2018	BRCA1 mediates Oct1 ubiquitylation and degradation, and mutation of two ubiquitylated Oct1 lysines insulates the protein against BRCA1-mediated destabilization.	Lysine	91-98	POU class 2 homeobox 1	Homo sapiens	86-90
15138260-6	2004	Our findings demonstrate that the level of RUNX3 protein is controlled by the competitive acetylation and deacetylation of the three lysine residues, revealing a new mechanism for the posttranslational regulation of RUNX3 expression.	Lysine	133-139	RUNX family transcription factor 3	Homo sapiens	43-48
15138260-6	2004	Our findings demonstrate that the level of RUNX3 protein is controlled by the competitive acetylation and deacetylation of the three lysine residues, revealing a new mechanism for the posttranslational regulation of RUNX3 expression.	Lysine	133-139	RUNX family transcription factor 3	Homo sapiens	216-221
15117942-3	2004	We show that Lys(684) and Lys(897) of NFAT1 can be sumoylated.	Lysine	13-16	nuclear factor of activated T cells 2	Homo sapiens	38-43
15117942-3	2004	We show that Lys(684) and Lys(897) of NFAT1 can be sumoylated.	Lysine	26-29	nuclear factor of activated T cells 2	Homo sapiens	38-43
29250818-7	2018	ATX4 and ATX5 directly bind to the AHG3 locus and trimethylate histone H3 of Lys 4 (H3K4).	Lysine	77-80	SET domain group 29	Arabidopsis thaliana	9-13
15117942-4	2004	The sumoylation at Lys(684) is required for NFAT1 transcriptional activity and subsequent sumoylation of Lys(897), whereas the sumoylation of Lys(897) is only required for nuclear anchorage.	Lysine	19-22	nuclear factor of activated T cells 2	Homo sapiens	44-49
15117942-5	2004	Because Lys(897) of NFAT1 is not conserved among other members of the NFAT family, we propose that sumoylation of Lys(897) may provide a mechanism for NFAT1 isotype-specific regulation of nuclear anchorage and transcriptional activation.	Lysine	8-11	nuclear factor of activated T cells 2	Homo sapiens	20-25
15117942-5	2004	Because Lys(897) of NFAT1 is not conserved among other members of the NFAT family, we propose that sumoylation of Lys(897) may provide a mechanism for NFAT1 isotype-specific regulation of nuclear anchorage and transcriptional activation.	Lysine	114-117	nuclear factor of activated T cells 2	Homo sapiens	20-25
15117942-5	2004	Because Lys(897) of NFAT1 is not conserved among other members of the NFAT family, we propose that sumoylation of Lys(897) may provide a mechanism for NFAT1 isotype-specific regulation of nuclear anchorage and transcriptional activation.	Lysine	114-117	nuclear factor of activated T cells 2	Homo sapiens	151-156
15248023-6	2004	After neutralization of excess negative charge with poly-L-lysine, these complexes served as a specific gene delivery vector for uPAR-expressing cells.	Lysine	52-65	plasminogen activator, urokinase receptor	Homo sapiens	129-133
2614645-1	1989	A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated.	Lysine	99-102	angiotensin-converting enzyme	Oryctolagus cuniculus	52-55
29250818-7	2018	ATX4 and ATX5 directly bind to the AHG3 locus and trimethylate histone H3 of Lys 4 (H3K4).	Lysine	77-80	protein phosphatase 2CA	Arabidopsis thaliana	35-39
29341608-8	2018	Furthermore, the study revealed that the invariant Lys, Lys73 in PKA and Lys437 in PKCepsilon, already known to have a crucial role in the catalytic activity of kinases, serves as the main anchor for balanol binding.	Lysine	51-54	protein kinase C epsilon	Homo sapiens	83-93
2668272-4	1989	Specific alterations in the pattern of methylation protection afforded by the Arg2----Lys mutant protein suggest that Arg2 contacts the N7 groups of guanines 10 and 12 in the operator.	Lysine	86-89	arginase 2	Homo sapiens	118-122
15497507-4	2004	We found that, similar to its human counterpart, Xenopus Hsf2 is sumoylated at lysine 82 and that, as it does in human Hsf2, the modification event of the small ubiquitin-related modifier 1 functions to increase the deoxyribonucleic acid-binding activity of this transcription factor in Xenopus.	Lysine	79-85	heat shock transcription factor 2 L homeolog	Xenopus laevis	57-61
15096521-6	2004	The product of the inhibition reaction is predominantly a soluble oligomer of alpha-synuclein, in which the protein molecules have been covalently modified by baicalein quinone to form a Schiff base with a lysine side chain in alpha-synuclein.	Lysine	206-212	synuclein alpha	Homo sapiens	78-93
2474456-2	1989	Histone H4 can be reversibly acetylated at lysine residues 5, 8, 12 and 16.	Lysine	43-49	H4 clustered histone 9	Homo sapiens	0-10
29345925-3	2018	In this study, the X-ray structure of a trapped E3-E2~NEDD8-target intermediate (RBX1-UBC1~NEDD8-CUL1-DCN1) is used to build computer models, and combined quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) and free energy (potential of mean force) simulations are performed to investigate the catalytic mechanism of the NEDD8 transfer from E2 to the lysine residue (K720) on the substrate in the complex.	Lysine	369-375	ubiquitin conjugating enzyme E2 K	Homo sapiens	86-90
15096521-6	2004	The product of the inhibition reaction is predominantly a soluble oligomer of alpha-synuclein, in which the protein molecules have been covalently modified by baicalein quinone to form a Schiff base with a lysine side chain in alpha-synuclein.	Lysine	206-212	synuclein alpha	Homo sapiens	227-242
29067790-4	2018	Candidate screening revealed that acetylation state of lysine 243 on BubR1 (BubR1-K243, an integral part of the spindle assembly checkpoint complex) functions during oocyte meiosis, and acetylation-mimetic mutant BubR1-K243Q results in the very similar phenotypes as Sirt2-knockdown oocytes.	Lysine	55-61	sirtuin 2	Mus musculus	267-272
15178428-4	2004	Particularly, the dibasic Arg-Lys sequence located at the carboxy-terminal end of KHD was shown to be crucial for the plasma membrane targeting of PIP5Kgamma, since the deletion or charge-reversal mutation of this dibasic sequence resulted in the mislocalization of the protein to the cytoplasm.	Lysine	30-33	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	Homo sapiens	147-157
2742853-5	1989	The magnitude of the change in Ki value suggests that in the complex, Lys-40 forms a salt bridge or hydrogen bond with an anionic moiety in PRI.	Lysine	70-73	ribonuclease/angiogenin inhibitor 1	Homo sapiens	140-143
2742853-9	1989	These results indicate that PRI inhibition minimally involves the three residues critical for the activity of angiogenin--Lys-40, His-13, and His-114--and to a lesser extent its single tryptophan, Trp-89.	Lysine	122-125	ribonuclease/angiogenin inhibitor 1	Homo sapiens	28-31
29352251-2	2018	PKR was identified as a target of SUMOylation and the triple PKR-SUMO deficient mutant on Lysine residues K60-K150-K440 has reduced PKR activity.	Lysine	90-96	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	0-3
2706247-7	1989	The different 13C-14 chemical shifts in these two M preparations may be explained by different C = N configurations of the retinal-lysine Schiff base linkage, namely, syn in NaCl and anti in guanidine hydrochloride.	Lysine	131-137	synemin	Homo sapiens	167-170
14990577-4	2004	A variety of structural alignment methods were applied and four highly conserved residues of human glutathione synthetase (Glu-144, Asn-146, Lys-305, and Lys-364) were identified in the binding site.	Lysine	141-144	glutathione synthetase	Homo sapiens	99-121
14990577-4	2004	A variety of structural alignment methods were applied and four highly conserved residues of human glutathione synthetase (Glu-144, Asn-146, Lys-305, and Lys-364) were identified in the binding site.	Lysine	154-157	glutathione synthetase	Homo sapiens	99-121
2492151-8	1989	Incorporation of 32Pi into eIF-2 alpha was two- to threefold higher in lysine-deprived cells than in hepatocytes incubated in fully supplemented medium.	Lysine	71-77	eukaryotic translation initiation factor 2A	Rattus norvegicus	27-38
29352251-2	2018	PKR was identified as a target of SUMOylation and the triple PKR-SUMO deficient mutant on Lysine residues K60-K150-K440 has reduced PKR activity.	Lysine	90-96	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	61-64
29352251-2	2018	PKR was identified as a target of SUMOylation and the triple PKR-SUMO deficient mutant on Lysine residues K60-K150-K440 has reduced PKR activity.	Lysine	90-96	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	61-64
29343685-1	2018	The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis.	Lysine	21-27	lysine methyltransferase 2A	Homo sapiens	84-87
2461932-2	1988	Single amino acid substitutions were generated in regions thought to be within the active site and catalytically important for the ATPase activity, changing lysine 181 and/or lysine 184 to glutamine, and aspartate 265 to valine and asparagine.	Lysine	157-163	ATPase	Escherichia coli	131-137
2461932-4	1988	Our results indicate that 1) these amino acid alterations in the proposed ATP-binding domain do not interfere with RNA binding; 2) substitution of lysine 184 by glutamine actually improves the ATPase and related activities while the same substitution at lysine 181 reduces but does not eliminate activity; 3) the double mutation changing both lysine 181 and lysine 184 to glutamine eliminates ATPase activity; and 4) the aspartate at 265 is also required for ATP hydrolysis but not for ATP binding.	Lysine	147-153	ATPase	Escherichia coli	193-199
29440247-5	2018	Depletion of KMT2D results in a broad loss of enhancer histone modifications H3 Lys 4 (H3K4) monomethylation (H3K4me1) and H3K27 acetylation (H3K27ac) as well as reduced expression of p63 target genes, including key genes involved in epithelial development and adhesion.	Lysine	80-83	lysine methyltransferase 2D	Homo sapiens	13-18
15137760-4	2004	Reporters developed using the chromodomains from HP1 and Polycomb respond to enzymatic methylation at the lysine 9 and lysine 27 positions of histone H3, respectively, giving 60% and 28% YFP/CFP emission ratio increases in vitro or in single living cells.	Lysine	106-112	chromobox 5	Homo sapiens	49-52
15137760-4	2004	Reporters developed using the chromodomains from HP1 and Polycomb respond to enzymatic methylation at the lysine 9 and lysine 27 positions of histone H3, respectively, giving 60% and 28% YFP/CFP emission ratio increases in vitro or in single living cells.	Lysine	119-125	chromobox 5	Homo sapiens	49-52
29326266-4	2018	In murine CD8+ T cells activated after Listeria monocytogenes infection, Suv39h1-dependent trimethylation of histone H3 lysine 9 controls the expression of a set of stem cell-related memory genes.	Lysine	120-126	suppressor of variegation 3-9 1	Mus musculus	73-80
15081381-10	2004	These results confirm the observations obtained with other basic molecules and suggest that the behavior induced by poly-l-lysine is mediated through the activation of the NMDA receptor ion-channel complex acting either on the polyamine recognition site or on the NR2B subunit.	Lysine	116-129	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	264-268
3072253-14	1988	In both GLK and the hexokinases, a lysine residue is also conserved at aa position 110 which probably corresponds to the ATP-binding site.	Lysine	35-41	glucokinase	Saccharomyces cerevisiae S288C	8-11
29070530-3	2018	Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in a therapeutically targetable manner.	Lysine	32-38	lysine (K)-specific demethylase 6A	Mus musculus	184-187
3223931-8	1988	203, 101-107] that lysine is the sixth ligand of native cytochrome f.	Lysine	19-25	cytochrome f	Brassica napus	56-68
15071505-1	2004	The Set1 protein of Saccharomyces cerevisiae is a histone methyltransferase (HMTase) acting on lysine 4 of histone H3.	Lysine	95-101	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	4-8
29634390-6	2018	Then we demonstrate that SETD7 methylates ATG16L1 at lysine 151 while KDM1A/LSD1 (lysine demethylase 1A) removes this methyl mark.	Lysine	53-59	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	25-30
15109265-4	2004	The side chain epsilon-amino group of Lys-52 has an apparent pK(a) of 6.4 +/- 0.2, and the protonation state of Lys-52 affects the spectral properties of the enzyme and the reactions with both hydrogen peroxide and HCN.	Lysine	38-41	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	215-218
15109265-4	2004	The side chain epsilon-amino group of Lys-52 has an apparent pK(a) of 6.4 +/- 0.2, and the protonation state of Lys-52 affects the spectral properties of the enzyme and the reactions with both hydrogen peroxide and HCN.	Lysine	112-115	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	215-218
15109265-5	2004	In its unprotonated form, Lys-52 acts as a base catalyst facilitating the reactions of both hydrogen peroxide and HCN with CcP(H52K).	Lysine	26-29	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	114-117
3061841-1	1988	Big gastrin comprising 34 amino acid residues (G34) consists of an N-terminal pentadecapeptide linked via two lysine residues to a C-terminal heptadecapeptide identical with little gastrin (G17).	Lysine	110-116	gastrin	Rattus norvegicus	4-11
2458720-0	1988	Alpha 2-antiplasmin"s carboxy-terminal lysine residue is a major site of interaction with plasmin.	Lysine	39-45	serpin family F member 2	Homo sapiens	0-19
2458720-1	1988	alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme"s active site.	Lysine	97-103	serpin family F member 2	Homo sapiens	0-19
29954236-4	2018	Cells deficient in ASF1A/B or CAF-1 exhibit reduced histone H4 lysine 16 acetylation (H4K16ac), a histone mark known to promote ATM activation.	Lysine	63-69	ATM serine/threonine kinase	Homo sapiens	128-131
2458720-3	1988	A synthetic peptide corresponding to the C-terminal 26 amino acid residues of AP blocked association of AP with plasmin, but this activity of the peptide was lost when its C-terminal lysine residue was removed with carboxypeptidase B.	Lysine	183-189	carboxypeptidase B1	Homo sapiens	215-233
2458720-4	1988	The essential role of this lysine residue was shown more directly by treating AP with carboxypeptidase B and observing that AP lost its ability to inhibit plasmin rapidly.	Lysine	27-33	carboxypeptidase B1	Homo sapiens	86-104
3149742-0	1988	Multiple interactions of lysine-128 of Escherichia coli glutamate dehydrogenase revealed by site-directed mutagenesis studies.	Lysine	25-31	glutamate dehydrogenase	Escherichia coli	56-79
3149742-1	1988	A highly conserved lysine at position 128 of Escherichia coli glutamate dehydrogenase (GDH) has been altered by site-directed mutagenesis of the gdhA gene.	Lysine	19-25	glutamate dehydrogenase	Escherichia coli	62-85
3149742-1	1988	A highly conserved lysine at position 128 of Escherichia coli glutamate dehydrogenase (GDH) has been altered by site-directed mutagenesis of the gdhA gene.	Lysine	19-25	glutamate dehydrogenase	Escherichia coli	87-90
3149742-1	1988	A highly conserved lysine at position 128 of Escherichia coli glutamate dehydrogenase (GDH) has been altered by site-directed mutagenesis of the gdhA gene.	Lysine	19-25	glutamate dehydrogenase	Escherichia coli	145-149
15006631-3	2004	Myofibrillar binding is mediated by major and minor lysine charge clamp motifs (K104/K115 [major] and K8/K24 [minor] in chicken M-CK) located in the N-terminal region [J.	Lysine	52-58	creatine kinase, M-type	Gallus gallus	128-132
14762098-2	2004	Plasma CPB down-regulates fibrinolysis by removing carboxy-terminal lysines, the ligands for plasminogen and tissue-type plasminogen activator (tPA), from partially degraded fibrin.	Lysine	68-75	carboxypeptidase B1	Rattus norvegicus	7-10
14762098-2	2004	Plasma CPB down-regulates fibrinolysis by removing carboxy-terminal lysines, the ligands for plasminogen and tissue-type plasminogen activator (tPA), from partially degraded fibrin.	Lysine	68-75	plasminogen activator, tissue type	Rattus norvegicus	109-142
3132453-3	1988	In previous work with the Amadori rearrangement product N alpha-formyl-N epsilon-fructoselysine (fFL), an analog of glycated lysine residues in proteins, we showed that fFL was oxidatively cleaved between C-2 and C-3 of the carbohydrate chain to yield N epsilon-carboxymethyllysine (CML) and D-erythronic acid.	Lysine	89-95	complement C3	Homo sapiens	213-216
30526305-6	2018	Although coexpression with MYC reduced certain RAS-induced senescence markers (histone H3 lysine 9 trimethylation and senescence-associated beta-GAL activity), the induction of the senescence marker p16INK4A was further enhanced and the culture ceased to proliferate within a few days, revealing that MYC could not fully suppress RAS-induced senescence.	Lysine	90-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-30
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	97-103	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	155-159
15121847-3	2004	It has been shown recently that following treatment of yeast cells with DNA-damaging agents, the lysine 164 residue of PCNA becomes monoubiquitinated in a Rad6-Rad18-dependent manner and that subsequently this PCNA residue is polyubiquitinated via a lysine 63-linked ubiquitin chain in an Mms2-Ubc13-, Rad5-dependent manner.	Lysine	250-256	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	155-159
15121847-6	2004	In addition, we provide evidence for the activation of the RAD52 recombinational pathway in the pol30-119 mutant and we infer that SUMO conjugation at the lysine 164 residue of PCNA has a role in suppressing the Rad52-dependent postreplicational repair pathway.	Lysine	155-161	recombinase RAD52	Saccharomyces cerevisiae S288C	59-64
15121847-6	2004	In addition, we provide evidence for the activation of the RAD52 recombinational pathway in the pol30-119 mutant and we infer that SUMO conjugation at the lysine 164 residue of PCNA has a role in suppressing the Rad52-dependent postreplicational repair pathway.	Lysine	155-161	recombinase RAD52	Saccharomyces cerevisiae S288C	212-217
3348809-3	1988	On the other hand, we determined the primary structure of human H-protein from the amino terminal Ser by the 12th Val, including a hexapeptide, -Glu-Lys-His-Glu-Trp-Val-.	Lysine	149-152	myosin binding protein H	Homo sapiens	64-73
29698889-5	2018	NEIL1 mutant having the substitution of Lys 296-298 with neutral Ala loses nuclear localization, whereas Lys &gt; Arg substitution (in 3KR mutant) at the same sites does not affect NEIL1"s nuclear localization or chromatin binding, presumably due to retention of the positive charge.	Lysine	40-43	nei like DNA glycosylase 1	Homo sapiens	0-5
3125994-5	1988	Pre-treatment of the in situ BPDE-I-modified H2A.2 from rat liver with carboxypeptidase B, which should remove the C-terminal lysine from the protein, resulted in increased retention times on reverse-phase HPLC for the adduct-containing peptides upon subsequent V8-protease digestion.	Lysine	126-132	histone cluster 2 H2A family member A2	Rattus norvegicus	45-50
15018907-4	2004	The conformation around the acetylated lysine of the cyclic hexapeptide substrate or the aminosuberate hydroxamic acid [Asu(NHOH)] of cyclic hexapeptide inhibitor is different from that around alpha-tubulin"s lysine-40.	Lysine	39-45	tubulin alpha 1b	Homo sapiens	193-206
29698889-11	2018	We thus conclude that the major role of acetylable Lys residues in NEIL1 is to stabilize the formation of chromatin-bound repair complexes which protect cells from oxidative stress.	Lysine	51-54	nei like DNA glycosylase 1	Homo sapiens	67-72
15018907-4	2004	The conformation around the acetylated lysine of the cyclic hexapeptide substrate or the aminosuberate hydroxamic acid [Asu(NHOH)] of cyclic hexapeptide inhibitor is different from that around alpha-tubulin"s lysine-40.	Lysine	209-215	tubulin alpha 1b	Homo sapiens	193-206
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	Lysine	102-108	MLLT1 super elongation complex subunit	Homo sapiens	144-147
14699107-3	2004	A 22-residue K3 peptide of beta(2)m, Ser(20)-Lys(41), obtained by digestion with Acromobacter protease I, forms amyloid fibrils without seeding.	Lysine	45-48	beta-2-microglobulin	Homo sapiens	27-35
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Lysine	96-102	coagulation factor X	Homo sapiens	47-56
2450354-1	1988	The sequence Lys-Ser-Pro-Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly repeats six times serially in the human midsized neurofilament (NF) protein (NF-M).	Lysine	13-16	neurofilament medium chain	Homo sapiens	142-146
2450354-1	1988	The sequence Lys-Ser-Pro-Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly repeats six times serially in the human midsized neurofilament (NF) protein (NF-M).	Lysine	33-36	neurofilament medium chain	Homo sapiens	142-146
28411331-1	2018	BACKGROUND: Glutaric acidemia Type 1 (GA-1) is an autosomal recessively inherited metabolic disorder which is associated with GCDH gene mutations which alters the glutaryl-CoA dehydrogenase, an enzyme playing role in the catabolic pathways of the amino acids lysine, hydroxylysine, and tryptophan.	Lysine	259-265	glutaryl-CoA dehydrogenase	Homo sapiens	126-130
2450354-1	1988	The sequence Lys-Ser-Pro-Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly repeats six times serially in the human midsized neurofilament (NF) protein (NF-M).	Lysine	33-36	neurofilament medium chain	Homo sapiens	142-146
14997518-4	2004	The crystal structure indicated the location of these lysines was distal to the phosphatidylserine binding sites on annexin V.	Lysine	54-61	annexin A5	Homo sapiens	116-125
28411331-1	2018	BACKGROUND: Glutaric acidemia Type 1 (GA-1) is an autosomal recessively inherited metabolic disorder which is associated with GCDH gene mutations which alters the glutaryl-CoA dehydrogenase, an enzyme playing role in the catabolic pathways of the amino acids lysine, hydroxylysine, and tryptophan.	Lysine	259-265	glutaryl-CoA dehydrogenase	Homo sapiens	163-189
14769928-1	2004	Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with hyperkalemia.	Lysine	55-61	WNK lysine deficient protein kinase 4	Homo sapiens	41-45
3126367-7	1988	By differential and sequential modification by 5,5"-dithio-bis(2-nitrobenzoic acid), TNBS and dithiothreitol, the residues of lysine and cysteine were identified in the active site of NADPH-cytochrome P-450 reductase.	Lysine	126-132	cytochrome p450 oxidoreductase	Rattus norvegicus	184-216
29115470-0	2018	Dimethylation of Histone 3 Lysine 9 is sensitive to the epileptic activity, and affects the transcriptional regulation of the potassium channel Kcnj10 gene in epileptic rats.	Lysine	27-33	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	144-150
3337729-5	1988	The amino acid sequence of the unknown Peak 1 proved to be Lys-Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg, or [Hyp3]-Lys-BK, and Peak 2 Lys-BK.	Lysine	59-62	pseudopodium enriched atypical kinase 1	Homo sapiens	39-45
14769936-5	2004	A subsequent database search revealed that the amino acid sequence of a lysine-rich C-terminal segment of HP0508 is identical to the C terminus of HP0863.	Lysine	72-78	plasminogen-binding protein PgbA	Helicobacter pylori 26695	106-112
14769936-6	2004	Recombinant proteins expressed from HP0508 and HP0863 bound plasminogen specifically and in a lysine-dependent manner.	Lysine	94-100	plasminogen-binding protein PgbA	Helicobacter pylori 26695	36-42
3141253-1	1988	A gap1 can1 mutant of Saccharomyces cerevisiae with a single lysine transport system remaining was used to study detailed kinetics of this transport.	Lysine	61-67	arginine permease CAN1	Saccharomyces cerevisiae S288C	7-11
29267323-5	2017	In the INCA cohort, the variant (Lys-containing) genotypes were significantly associated with lower proportion of tCR (ORadj = 0.92; 95%CI = 0.85-0.99), whereas in the NKI-AVL cohort they were associated with tumor grade 3 (p = 0.035) and with triple-negative subtype (p = 0.032), but not with clinical outcomes.	Lysine	33-36	caspase recruitment domain family member 17	Homo sapiens	7-11
14660660-0	2004	Critical role for lysine 133 in the nuclear ubiquitin-mediated degradation of MyoD.	Lysine	18-24	myogenic differentiation 1	Mus musculus	78-82
14660660-2	2004	The degradation of MyoD can occur via an NH2 terminus-dependent pathway or a lysine-dependent pathway, suggesting that MyoD ubiquitination may be driven by different mechanisms.	Lysine	77-83	myogenic differentiation 1	Mus musculus	19-23
14660660-3	2004	To understand this process, deletion analysis was used to identify the region of MyoD that is required for rapid proteolysis in the lysine-dependent pathway.	Lysine	132-138	myogenic differentiation 1	Mus musculus	81-85
3481261-5	1987	The high concordance in 48 RI strains of Es-25 with Ly-18 indicated the location of Es-25 on chromosome 12.	Lysine	52-54	esterase 25	Mus musculus	84-89
30555625-3	2018	Exchanging specific residues for lysine improves binding affinity for Hsp90, indicating some residues are not critical for interacting with the target, whereas others are essential.	Lysine	33-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75
3481261-6	1987	The gene order Es-25-Ly-18-D12Nyul-Pre-1 was proposed.	Lysine	21-23	esterase 25	Mus musculus	15-20
3109980-0	1987	Deletion of lysine 13 alters the structure and function of parathyroid hormone.	Lysine	12-18	parathyroid hormone	Bos taurus	59-78
3109980-2	1987	CNBr cleavage and amino acid analysis showed that this peptide is the des-lys-13 form of 1-34 bovine PTH.	Lysine	32-35	parathyroid hormone	Bos taurus	101-104
14660660-4	2004	Here we report that the basic helix-loop-helix domain is required for ubiquitination and lysine-dependent degradation of MyoD in the nucleus.	Lysine	89-95	myogenic differentiation 1	Mus musculus	121-125
14660660-5	2004	Site-directed mutagenesis in MyoD revealed that lysine 133 is the major internal lysine of ubiquitination.	Lysine	48-54	myogenic differentiation 1	Mus musculus	29-33
14660660-5	2004	Site-directed mutagenesis in MyoD revealed that lysine 133 is the major internal lysine of ubiquitination.	Lysine	81-87	myogenic differentiation 1	Mus musculus	29-33
14660660-6	2004	The half-life of the MyoD K133R mutant protein was longer than that of wild type MyoD, substantiating the implication of lysine 133 in the turnover of MyoD in myoblasts.	Lysine	121-127	myogenic differentiation 1	Mus musculus	21-25
14660660-8	2004	Taken together, our data demonstrate that lysine 133 is targeted for ubiquitination and rapid degradation of MyoD in the lysine-dependent pathway and plays an integral role in compromising MyoD activity in the nucleus.	Lysine	42-48	myogenic differentiation 1	Mus musculus	109-113
14660660-8	2004	Taken together, our data demonstrate that lysine 133 is targeted for ubiquitination and rapid degradation of MyoD in the lysine-dependent pathway and plays an integral role in compromising MyoD activity in the nucleus.	Lysine	42-48	myogenic differentiation 1	Mus musculus	189-193
14660660-8	2004	Taken together, our data demonstrate that lysine 133 is targeted for ubiquitination and rapid degradation of MyoD in the lysine-dependent pathway and plays an integral role in compromising MyoD activity in the nucleus.	Lysine	121-127	myogenic differentiation 1	Mus musculus	109-113
14660660-8	2004	Taken together, our data demonstrate that lysine 133 is targeted for ubiquitination and rapid degradation of MyoD in the lysine-dependent pathway and plays an integral role in compromising MyoD activity in the nucleus.	Lysine	121-127	myogenic differentiation 1	Mus musculus	189-193
3109980-8	1987	The results show that Lys-13 is important in the folding of the active domain of PTH, and are interpreted in the context of a previously published model for the folding of this hormone.	Lysine	22-25	parathyroid hormone	Bos taurus	81-84
28814116-4	2017	The sliding surface can be modulated (i) through lysine acetylation, which triggers PCNA degradation during nucleotide excision repair (NER) and stimulates repair by homologous recombination (HR) or (ii) through binding of the protein factor p15PAF, which turns off DNA lesion bypass.	Lysine	49-55	proliferating cell nuclear antigen	Homo sapiens	84-88
3029086-2	1987	Analyses of peptide products generated from limited proteolytic digestion of the calmodulin conjugate containing a single ubiquitin indicate that lysine 115 on calmodulin is the site of linkage.	Lysine	146-152	calmodulin 2	Gallus gallus	81-91
3029086-2	1987	Analyses of peptide products generated from limited proteolytic digestion of the calmodulin conjugate containing a single ubiquitin indicate that lysine 115 on calmodulin is the site of linkage.	Lysine	146-152	calmodulin 2	Gallus gallus	160-170
3029086-6	1987	The bacterially expressed calmodulin, unlike the Dictyostelium protein, can also form conjugates containing a 2-5 molar ratio of ubiquitin but at a slower rate than that observed for conjugation at lysine 115.	Lysine	198-204	calmodulin 2	Gallus gallus	26-36
3029086-7	1987	Results from these studies further support our hypothesis that the post-translational methylation of lysine 115 found in most forms of calmodulin serves the important function of protecting calmodulin from ubiquitination and from degradation by the cytoplasmic ubiquitin-dependent proteolytic pathway.	Lysine	101-107	calmodulin 2	Gallus gallus	135-145
3029086-7	1987	Results from these studies further support our hypothesis that the post-translational methylation of lysine 115 found in most forms of calmodulin serves the important function of protecting calmodulin from ubiquitination and from degradation by the cytoplasmic ubiquitin-dependent proteolytic pathway.	Lysine	101-107	calmodulin 2	Gallus gallus	190-200
14707061-4	2004	Physical linkage to DAP12 requires lysine-183 in the NKp44 transmembrane domain.	Lysine	35-41	transmembrane immune signaling adaptor TYROBP	Homo sapiens	20-25
15094825-1	2004	Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively.	Lysine	110-113	interleukin 1 receptor antagonist	Homo sapiens	35-41
3100332-0	1987	Sequence identity between a lysine-containing peptide from Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase and an active site peptide from human erythrocyte glucose-6-phosphate dehydrogenase.	Lysine	28-34	glucose-6-phosphate dehydrogenase	Homo sapiens	169-202
28814116-4	2017	The sliding surface can be modulated (i) through lysine acetylation, which triggers PCNA degradation during nucleotide excision repair (NER) and stimulates repair by homologous recombination (HR) or (ii) through binding of the protein factor p15PAF, which turns off DNA lesion bypass.	Lysine	49-55	PCNA clamp associated factor	Homo sapiens	242-248
28846832-7	2017	The HOTAIR-N promoter exhibited increased trimethylation of histone H3 lysine 4, a histone marker of active transcription, and binding of BRD4, a reader of transcriptionally active histone markers.	Lysine	71-77	HOX transcript antisense RNA	Homo sapiens	4-10
3131025-1	1987	Derepression of lysine biosynthetic enzymes of Saccharomyces cerevisiae was investigated in lys9 auxotrophs which lack saccharopine reductase activity.	Lysine	16-22	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	92-96
3131025-7	1987	These results suggest that lys9 mutants represent a lesion for the saccharopine reductase and may represent a repressor mutation which in the wild-type cells simultaneously represses unlinked structural genes that encode for five of the lysine biosynthetic enzymes.	Lysine	237-243	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	27-31
29138491-5	2017	We further identify that the putative SUMOylation site of Bombyx Plk1 at lysine 466 is required for its localization on centrosomes, and K466 mutation in Plk1 could influence its interaction with Smt3/Ubc9 complex.	Lysine	73-79	ubiquitin-like protein SMT3	Bombyx mori	196-200
3128785-10	1987	It is concluded that acetylation of calmodulin at either lysine 21 or 75 markedly reduces its affinity for MLC kinase, but acetylation at any of the other lysines (13, 30, 77, 94, or 148) has only minor effects.	Lysine	57-63	calmodulin 2	Gallus gallus	36-46
13130121-0	2004	Mutation of lysine residues in apolipoprotein B-100 causes defective lipoprotein[a] formation.	Lysine	12-18	apolipoprotein B	Mus musculus	31-51
13130121-1	2004	Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,326 and apo[a]Cys4,057.	Lysine	79-85	apolipoprotein B	Mus musculus	112-132
13130121-1	2004	Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,326 and apo[a]Cys4,057.	Lysine	79-85	apolipoprotein B	Mus musculus	134-142
28980801-8	2017	In addition, we demonstrated that quantification on MS2 fragment ion level makes it possible to precisely quantify each individual ubiquitinated lysine residue in 39 K-epsilon-GG peptides bearing two ubiquitination sites by the use of specific ubiquitinated b, y ion pairs.	Lysine	145-151	MS2	Homo sapiens	52-55
14749535-1	2003	Deoxyhypusine is a modified lysine and formed posttranslationally to be the eukaryotic initiation factor eIF5A by deoxyhypusine synthase, employing spermidine as butylamine donor.	Lysine	28-34	eukaryotic translation initiation factor 5A	Homo sapiens	105-110
3491048-5	1986	However, the cross-reactivity with BCG was regained in the MTP derivative that was formed by adding lysine to dipeptide containing methylalanine or valine.	Lysine	100-106	lysosomal-associated protein transmembrane 4A	Mus musculus	59-62
2877981-8	1986	The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI.	Lysine	70-73	serpin family F member 2	Homo sapiens	166-175
14506260-0	2003	Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3"-DNA/5"-RNA terminus of the heteroduplex substrate.	Lysine	43-50	ribonuclease H1	Homo sapiens	6-14
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	176-182	eukaryotic translation initiation factor 5A	Homo sapiens	78-110
14523001-3	2003	Cat-1, the transporter for the essential amino acids, arginine and lysine, is one of the up-regulated genes.	Lysine	67-73	GIT ArfGAP 1	Homo sapiens	0-5
2877981-8	1986	The peptide contains a single lysine at position 303, indicating that Lys-303 of fibrinogen A alpha chain is the lysine residue that forms a cross-link with Gln-2 of alpha 2PI.	Lysine	113-119	serpin family F member 2	Homo sapiens	166-175
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	176-182	eukaryotic translation initiation factor 5A	Homo sapiens	112-117
2432921-3	1986	Cleavage of radiomethylated 70-kilodalton (kDa) DAF with papain released the labeled ethanolamine and glucosamine and generated 61- and 55-kDa DAF products that retained all labeled Lys and labeled N-terminal Asp.	Lysine	182-185	CD55 molecule (Cromer blood group)	Homo sapiens	48-51
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	233-240	eukaryotic translation initiation factor 5A	Homo sapiens	78-110
28819816-1	2017	Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N epsilon -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N epsilon -4-amino-2-hydroxybutyl(lysine)].	Lysine	233-240	eukaryotic translation initiation factor 5A	Homo sapiens	112-117
28784321-2	2017	In this study, the roles of YHM2, ODC1 and ODC2 in the assimilation of nitrogen and in the biosynthesis of lysine have been investigated.	Lysine	107-113	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	43-47
3014531-2	1986	Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities of p21.	Lysine	5-11	eukaryotic translation elongation factor 1 alpha 1	Mus musculus	116-136
3014531-2	1986	Both lysine (116K) and tyrosine (116Y) mutations of asparagine-116, which, by analogy with the crystal structure of elongation factor Tu (EF-Tu), has critical interactions with the guanine base, abolish GTP binding and transforming activities of p21.	Lysine	5-11	eukaryotic translation elongation factor 1 alpha 1	Mus musculus	138-143
3783686-6	1986	The overall incorporation of lysine into globin from a fully modified tRNALys that decodes AAG is faster by 25 to 30% than from the corresponding hypomodified tRNALys.	Lysine	29-35	N-methylpurine DNA glycosylase	Homo sapiens	91-94
14624463-6	2003	Among three other epigenetic modifications examined, histone H3 lysine 9 methylation correlated well with Igf2 allelic expression in CNS.	Lysine	64-70	insulin-like growth factor 2	Mus musculus	106-110
14645543-2	2003	By comparing the pattern of histone modifications at the mouse and human c-myc alleles, we identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3.	Lysine	240-246	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-78
14645543-2	2003	By comparing the pattern of histone modifications at the mouse and human c-myc alleles, we identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3.	Lysine	240-246	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	152-157
28784321-9	2017	These results provide evidence that only the simultaneous absence of YHM2, ODC1 and ODC2 impairs the export from the mitochondrial matrix of i) 2-oxoglutarate which is necessary for the synthesis of glutamate and ammonium fixation in the cytosol and ii) 2-oxoadipate which is required for lysine biosynthesis in the cytosol.	Lysine	289-295	mitochondrial 2-oxodicarboxylate carrier	Saccharomyces cerevisiae S288C	84-88
28967912-1	2017	Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Trr in Drosophila melanogaster and MLL3 (encoded by KMT2C) and MLL4 (encoded by KMT2D) in mammals.	Lysine	11-17	lysine (K)-specific methyltransferase 2D	Mus musculus	241-245
14576288-9	2003	AtPEX10 fused to yellow fluorescent protein colocalized with green fluorescent protein-serine-lysine-leucine, a well-documented peroxisomal marker, suggesting that AtPEX10 encodes a peroxisomal protein that is essential for normal embryo development and viability.	Lysine	94-100	peroxin 10	Arabidopsis thaliana	0-7
14576288-9	2003	AtPEX10 fused to yellow fluorescent protein colocalized with green fluorescent protein-serine-lysine-leucine, a well-documented peroxisomal marker, suggesting that AtPEX10 encodes a peroxisomal protein that is essential for normal embryo development and viability.	Lysine	94-100	peroxin 10	Arabidopsis thaliana	164-171
3745142-7	1986	These results indicated that the plasminogen-binding site(s) of alpha 2-plasmin inhibitor could be located in the COOH-terminal region of its molecule and that some of epsilon-NH2-groups in the deamidinated peptide T-11 may be involved in the lysine-binding site(s) of plasmin(ogen).	Lysine	243-249	serpin family F member 2	Homo sapiens	64-89
2874797-2	1986	Previous studies have pointed towards a cofactor role for pyridoxal 5"-phosphate (PLP) in lysyl oxidase, the enzyme that generates the peptidyl aldehyde precursor to the lysine-derived cross-linkages in elastin and collagen.	Lysine	170-176	lysyl oxidase	Bos taurus	90-103
3007131-9	1986	From those results, we propose that one residue of lysine is located at the binding site of the 2"-phosphate group on the adenosine ribose of NADP(H), and plays an essential role in the catalytic function of the NADPH-cytochrome P-450 reductase.	Lysine	51-57	cytochrome p450 oxidoreductase	Rattus norvegicus	212-244
14645481-4	2003	This residue (UV: lysine vs blue:asparagine or glutamate) corresponds to amino acid position glycine 90 (G90) in bovine rhodopsin, a site affected in autosomal dominant human congenital night blindness.	Lysine	18-24	rhodopsin	Bos taurus	120-129
29053956-4	2017	Following viral infection, the ubiquitin-binding domain in WHIP bridges RIG-I with MAVS by binding to polyUb chains of RIG-I at lysine 164.	Lysine	128-134	mitochondrial antiviral signaling protein	Homo sapiens	83-87
14592468-1	2003	A short stretch of 13 amino acids in the central portion of human beta-casein contains four positively charged conserved residues, three Lys and one Arg.	Lysine	137-140	casein beta	Homo sapiens	66-77
3008720-0	1986	Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils.	Lysine	13-19	elastin	Homo sapiens	35-42
3008720-1	1986	Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release.	Lysine	17-23	elastin	Homo sapiens	32-39
3008720-1	1986	Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release.	Lysine	174-180	elastin	Homo sapiens	32-39
28886479-2	2017	Build-up of fibrous tissue occurs through the cross-linking of collagen or elastin monomers, which is initiated through the oxidation of lysine residues to form alpha-aminoadipic-delta-semialdehyde (allysine).	Lysine	137-143	elastin	Mus musculus	75-82
2937708-7	1986	Glucose-6-phosphate dehydrogenase and RNase, the activities of which depend on a lysine residue at their catalytic sites, were inhibited in a dose- and time-dependent manner.	Lysine	81-87	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
14633678-1	2003	Histone methyltransferase (HMT)(1) class enzymes that methylate lysine residues of histones or proteins contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain.	Lysine	64-70	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	0-33
28937994-7	2017	Furthermore, we identify for the first time a significant interaction between lysine residues of the protein and POPS lipids that occurs independently of Ca2+ suggesting that AnxA2-membrane interactions can also occur in a low Ca2+ environment.	Lysine	78-84	annexin A2	Homo sapiens	175-180
14625171-4	2003	RESULTS: Sequence analysis confirmed the presence of the desired mutation site, and a mutation from K (Lys) to N (Asn) in codon 317 was identified in the SCN5A gene, indicating the successful induction of the mutation at K317N of the SCN5A gene.	Lysine	103-106	sodium voltage-gated channel alpha subunit 5	Homo sapiens	154-159
14625171-4	2003	RESULTS: Sequence analysis confirmed the presence of the desired mutation site, and a mutation from K (Lys) to N (Asn) in codon 317 was identified in the SCN5A gene, indicating the successful induction of the mutation at K317N of the SCN5A gene.	Lysine	103-106	sodium voltage-gated channel alpha subunit 5	Homo sapiens	234-239
2430174-1	1986	All 15 protein kinases whose amino acid sequence is known contain a lysine residue at a position homologous to that of lysine-295 in p60src, the transforming protein of Rous sarcoma virus.	Lysine	68-74	p60 src	Rous sarcoma virus	133-139
2430174-1	1986	All 15 protein kinases whose amino acid sequence is known contain a lysine residue at a position homologous to that of lysine-295 in p60src, the transforming protein of Rous sarcoma virus.	Lysine	119-125	p60 src	Rous sarcoma virus	133-139
2430174-4	1986	Lysine-295 in p60src was replaced with a glutamic acid, an arginine, or a histidine residue, and mutant p60src proteins were characterized in chicken cells infected by mutant viruses.	Lysine	0-6	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-20
3089951-0	1986	Inhibition by lysine and arginine of the conversion of C3 and B in the serum and a purified system.	Lysine	14-20	complement C3	Homo sapiens	55-63
3089951-7	1986	The addition of arginine and lysine resulted in the inhibition of the conversion of C3 and B in the serum at elevated temperature.	Lysine	29-35	complement C3	Homo sapiens	84-92
3089951-9	1986	In the purified system, only arginine and lysine prevented the conversion of C3 and B, when C3, B and D were incubated in the presence of Mg++ and amino-acids.	Lysine	42-48	complement C3	Homo sapiens	77-85
3089951-9	1986	In the purified system, only arginine and lysine prevented the conversion of C3 and B, when C3, B and D were incubated in the presence of Mg++ and amino-acids.	Lysine	42-48	complement C3	Homo sapiens	92-103
14563679-3	2003	Substitution of the H2B ubiquitylation site at Lys 123 (K123) lowered transcription of certain genes regulated by the acetylation complex SAGA.	Lysine	47-50	H2B clustered histone 21	Homo sapiens	20-23
14563679-8	2003	In addition, disruption of either ubiquitylation or Ubp8-mediated deubiquitylation of H2B resulted in altered levels of gene-associated H3 Lys 4 methylation and Lys 36 methylation, which have both been linked to transcription.	Lysine	139-142	H2B clustered histone 21	Homo sapiens	86-89
14563679-8	2003	In addition, disruption of either ubiquitylation or Ubp8-mediated deubiquitylation of H2B resulted in altered levels of gene-associated H3 Lys 4 methylation and Lys 36 methylation, which have both been linked to transcription.	Lysine	161-164	H2B clustered histone 21	Homo sapiens	86-89
3089951-10	1986	Since lysine and arginine did not inhibit the enzymatic activity of D, these data suggest that arginine and lysine prevent the interaction of C3 and B in the serum at elevated temperatures.	Lysine	108-114	complement C3	Homo sapiens	142-150
28534516-6	2017	HOTTIP directly bound the adaptor protein WDR5 and drove histone H3 lysine 4 trimethylation and HOXA13 gene transcription in ESCC cells.	Lysine	68-74	HOXA distal transcript antisense RNA	Homo sapiens	0-6
2995366-3	1985	Recombinant DNA-derived hTNF-beta was radiolabeled with [3H]propionyl succinimidate at the lysine residues of the molecule to a specific activity of 200 microCi/nmol of protein.	Lysine	91-97	lymphotoxin alpha	Homo sapiens	24-33
28717007-5	2017	Mechanistically, additional results indicated that the RE1-silencing transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter in an NME2-dependent way and that this assembly is required for maintaining repressive chromatin at the hTERT promoter.	Lysine	97-103	telomerase reverse transcriptase	Homo sapiens	183-188
3886572-4	1985	BBI possesses two independent sites of inhibition, one at Lys 16-Ser 17 against trypsin and the other at Leu 43-Ser 44 against chymotrypsin.	Lysine	58-61	Bowman-Birk type proteinase inhibitor	Glycine max	0-3
12917426-2	2003	The SP of the pre-glycoprotein (pGP-C) of the lymphocytic choriomeningitis virus SPGP-C (signal peptide of pGP-C) shows different properties: 1) The SPGP-C is unusually long (58 amino acid residues) and contains two hydrophobic segments interrupted by a lysine residue.	Lysine	254-260	phosphoglycolate phosphatase	Homo sapiens	32-35
14572906-7	2003	Even though the functional and the in vivo properties of rHSA could be effected differently by the minor conformational changes caused by the triple-residue mutation and glycation, the present findings indicate that the effect of glycation can be partly explained by blockage of the positive charges of lysine at positions 199, 439 and 525.	Lysine	303-309	CD24 molecule	Rattus norvegicus	57-61
28717007-5	2017	Mechanistically, additional results indicated that the RE1-silencing transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter in an NME2-dependent way and that this assembly is required for maintaining repressive chromatin at the hTERT promoter.	Lysine	97-103	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	204-208
28717007-5	2017	Mechanistically, additional results indicated that the RE1-silencing transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter in an NME2-dependent way and that this assembly is required for maintaining repressive chromatin at the hTERT promoter.	Lysine	97-103	telomerase reverse transcriptase	Homo sapiens	302-307
6437858-2	1984	The C-terminal amino acid of tissue MM creatine kinase from all 3 species was shown to be lysine, a specific substrate for carboxypeptidase-N and B.	Lysine	90-96	carboxypeptidase B1	Homo sapiens	123-147
28549158-5	2017	Furthermore, chromatin immunoprecipitation followed by sequencing revealed alterations in the nucleosome occupancy of the histone variant H3.3 for developmentally regulated genes in Chd2-depleted ESCs, which in turn led to elevated trimethylation of the histone H3 lysine 27.	Lysine	265-271	chromodomain helicase DNA binding protein 2	Mus musculus	182-186
6432779-0	1984	Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.	Lysine	113-119	lecithin-cholesterol acyltransferase	Homo sapiens	9-45
12876293-3	2003	This role of Rtf1 resembles that of Rad6, which mediates ubiquitination of histone H2B at lysine 123.	Lysine	90-96	Rtf1p	Saccharomyces cerevisiae S288C	13-17
12876293-3	2003	This role of Rtf1 resembles that of Rad6, which mediates ubiquitination of histone H2B at lysine 123.	Lysine	90-96	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	36-40
28878225-8	2017	This effect is mediated by transcriptional activation as evidenced by H3 acetylation on lysine 27 on the LDLR promoter.	Lysine	88-94	low density lipoprotein receptor	Homo sapiens	105-109
14527417-6	2003	Furthermore, this repression also requires a functional N-CoR deacetylase complex, which brings about histone hypoacetylation and methylation of H3 lysine 9 to the MTA2 locus.	Lysine	148-154	nuclear receptor corepressor 1	Homo sapiens	56-61
6430122-10	1984	Nearly complete methylation of the lysines of lysozyme, chicken ovomucoid, and ribonuclease was achieved with formaldehyde at pH 7.0 after 2 h at room temperature, with the retention of full activity of the protein without any destruction of tryptophan.	Lysine	35-42	serine peptidase inhibitor, Kazal type 7 (putative)	Gallus gallus	64-73
28677728-14	2017	Furthermore, overexpression of SIRT1 significantly activated anti-apoptotic effects by deacetylating lysine residue binding to protein kinase B and decreasing the activity of caspases 3, 9 and subsequent pathways.	Lysine	101-107	sirtuin 1	Mus musculus	31-36
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	2,4-dienoyl-CoA reductase 1	Homo sapiens	4-9
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	2,4-dienoyl-CoA reductase 1	Homo sapiens	45-50
6424712-1	1984	The NADPH-cytochrome c reductase activity of NADPH-adrenodoxin reductase from NADPH to cytochrome c via adrenodoxin was inhibited by pyridoxal 5"-phosphate and other reagents that modified the lysine residues.	Lysine	193-199	2,4-dienoyl-CoA reductase 1	Homo sapiens	45-50
12885250-0	2003	Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity.	Lysine	12-19	myosin heavy chain 14	Homo sapiens	49-55
12759363-8	2003	These activities distinguish DEN1 from the COP9 signalosome, which is capable of efficiently cleaving the Lys-720CUL1-Nedd8 conjugate, but lacks Nedd8 C-terminal hydrolytic activity and poorly processes hyperneddylated CUL1.	Lysine	106-109	COP9 signalosome subunit 8	Homo sapiens	43-47
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Lysine	86-92	pleckstrin	Homo sapiens	108-111
6373642-5	1984	We have previously shown that the replacement of histidine at position B10 by lysine resulted in an analogue displaying ca.	Lysine	78-84	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	71-74
28860381-3	2017	beta2AR ligands modulate SNCA transcription through histone 3 lysine 27 acetylation of its promoter and enhancers.	Lysine	62-68	adenosine A2a receptor	Homo sapiens	0-7
6242871-3	1984	The Ly-7.2 antigen also had an unusual distribution on cells responding to mitogens: leucoagglutinin-responsive cells were Ly-7.2-, concanavalin A Ly-7.2+, pokeweed mitogen Ly-7.2+/-, and lipopolysaccharide Ly-7.2-, i.e., Ly-7 can distinguish between subpopulations of T cells which respond to mitogens (phytohaemagglutinin and concanavalin A).	Lysine	4-6	FMS-like tyrosine kinase 3	Mus musculus	123-129
6242871-3	1984	The Ly-7.2 antigen also had an unusual distribution on cells responding to mitogens: leucoagglutinin-responsive cells were Ly-7.2-, concanavalin A Ly-7.2+, pokeweed mitogen Ly-7.2+/-, and lipopolysaccharide Ly-7.2-, i.e., Ly-7 can distinguish between subpopulations of T cells which respond to mitogens (phytohaemagglutinin and concanavalin A).	Lysine	4-6	FMS-like tyrosine kinase 3	Mus musculus	123-129
6242871-3	1984	The Ly-7.2 antigen also had an unusual distribution on cells responding to mitogens: leucoagglutinin-responsive cells were Ly-7.2-, concanavalin A Ly-7.2+, pokeweed mitogen Ly-7.2+/-, and lipopolysaccharide Ly-7.2-, i.e., Ly-7 can distinguish between subpopulations of T cells which respond to mitogens (phytohaemagglutinin and concanavalin A).	Lysine	4-6	FMS-like tyrosine kinase 3	Mus musculus	123-129
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Lysine	86-92	pleckstrin	Homo sapiens	179-182
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Lysine	296-302	pleckstrin	Homo sapiens	108-111
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Lysine	296-302	pleckstrin	Homo sapiens	179-182
12650641-4	2003	Recombinant p47-phox proteins with mutations in either the linker region or the arginine/lysine-rich domain were active in the absence of arachidonic acid stimulation in a cell-free NADPH oxidase system consisting of recombinant p67-phox, Rac1-guanosine 5"-[gamma-thio]triphosphate and neutrophil membranes.	Lysine	89-95	pleckstrin	Homo sapiens	12-15
6242871-3	1984	The Ly-7.2 antigen also had an unusual distribution on cells responding to mitogens: leucoagglutinin-responsive cells were Ly-7.2-, concanavalin A Ly-7.2+, pokeweed mitogen Ly-7.2+/-, and lipopolysaccharide Ly-7.2-, i.e., Ly-7 can distinguish between subpopulations of T cells which respond to mitogens (phytohaemagglutinin and concanavalin A).	Lysine	4-6	FMS-like tyrosine kinase 3	Mus musculus	123-129
28860381-3	2017	beta2AR ligands modulate SNCA transcription through histone 3 lysine 27 acetylation of its promoter and enhancers.	Lysine	62-68	synuclein alpha	Homo sapiens	25-29
28854355-2	2017	Herein, we show that the 70-kDa subunit of RPA (RPA1) is acetylated on lysine 163 by the acetyltransferases GCN5 and PCAF and that such acetylation is reversed principally via the action of the deacetylase HDAC6.	Lysine	71-77	replication protein A1	Homo sapiens	43-46
6714935-11	1984	Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine.	Lysine	135-141	arginyl aminopeptidase	Homo sapiens	48-64
12805230-5	2003	A surprising finding is that the characteristic interaction of HP1 chromodomains with histone H3 at methylated lysine 9 is not detected in preformed chromatin due to its inaccessibility.	Lysine	111-117	chromobox 5	Homo sapiens	63-66
28854355-2	2017	Herein, we show that the 70-kDa subunit of RPA (RPA1) is acetylated on lysine 163 by the acetyltransferases GCN5 and PCAF and that such acetylation is reversed principally via the action of the deacetylase HDAC6.	Lysine	71-77	replication protein A1	Homo sapiens	48-52
6443778-0	1984	Influence of copper-lysine complex on the formation of desmosine cross-links in elastin.	Lysine	20-26	elastin	Homo sapiens	80-87
28808245-4	2017	We revealed the requirement for an uncommon centrally localized lysine residue at position +2 of CAS SH3 ligands and two rather dissimilar optional anchoring residues, leucine and arginine, at position +5.	Lysine	64-70	BCAR1 scaffold protein, Cas family member	Homo sapiens	97-100
6644098-2	1983	Incubation of isolated epidermal cells with mM concentrations of glycine, asparagine, glutamic acid, canavanine, arginine, and/or lysine inhibited dramatically the induction of ornithine decarboxylase activity by the tumor promoter.	Lysine	130-136	ornithine decarboxylase, structural 1	Mus musculus	177-200
12813029-3	2003	AIP1 binds to the C-terminal domain of ASK1 via a lysine-rich cluster within the N-terminal C2 domain.	Lysine	50-56	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	39-43
12665517-4	2003	276, 28314-28320) were placed on Lys side chains of gp120.	Lysine	33-36	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	52-57
28793258-9	2017	These findings establish SIRT2-regulated lysine acetylation as a form of AMPAR post-translational modification that regulates its turnover, as well as synaptic plasticity and cognitive function.	Lysine	41-47	sirtuin 2	Mus musculus	25-30
12764109-8	2003	A significant decrease in CNP+/TUNEL+ oligodendrocytes was observed when recombinant human Gas6 (rhGas6) was administered to oligodendrocytes plated on poly-L-lysine, supporting a role for Gas6 signaling in oligodendrocyte survival during a period of active myelination in human fetal spinal cord development.	Lysine	152-165	growth arrest specific 6	Homo sapiens	91-95
6412747-0	1983	Regulation of elastolysis of insoluble elastin by human leukocyte elastase: stimulation by lysine-rich ligands, anionic detergents, and ionic strength.	Lysine	91-97	elastin	Homo sapiens	39-46
28789338-3	2017	HOTAIR mediates the trimethylation of histone H3 at lysine 27 and the demethylation of histone H3 dimethyl Lys4 by recruiting the polycomb repressive complex 2 and the lysine-specific demethylase 1/co-repressor of RE1-silencing transcription factor (coREST)/REST complex to the target gene promoters, which leads to gene silencing.	Lysine	52-58	HOX transcript antisense RNA	Homo sapiens	0-6
6349701-7	1983	Proteinase II converts kallidin to bradykinin by splitting off the N-terminal lysine.	Lysine	78-84	kininogen 1	Bos taurus	35-45
6404277-1	1983	Biproduct analogs of lysine and arginine are potent inhibitors of enkephalin convertase, a carboxypeptidase B-like enzyme which appears to be physiologically associated with enkephalin biosynthesis.	Lysine	21-27	carboxypeptidase B1	Homo sapiens	91-109
12706348-10	2003	Taken together, these results suggest that the lysine-rich domains and conserved amino acid residues of p67 are involved in the regulation of eIF2alpha phosphorylation during heat shock.	Lysine	47-53	methionyl aminopeptidase 2	Rattus norvegicus	104-107
12769850-5	2003	We show that interaction of MOF with MSL-3 leads to specific acetylation of MSL-3 at a single lysine residue adjacent to one of its chromodomains.	Lysine	94-100	males absent on the first	Drosophila melanogaster	28-31
28789338-3	2017	HOTAIR mediates the trimethylation of histone H3 at lysine 27 and the demethylation of histone H3 dimethyl Lys4 by recruiting the polycomb repressive complex 2 and the lysine-specific demethylase 1/co-repressor of RE1-silencing transcription factor (coREST)/REST complex to the target gene promoters, which leads to gene silencing.	Lysine	168-174	HOX transcript antisense RNA	Homo sapiens	0-6
28915556-3	2017	Here we report biological significance of SMYD2-mediated lysine 133 (K133) methylation of beta-catenin on its nuclear translocation.	Lysine	57-63	SET and MYND domain containing 2	Homo sapiens	42-47
12591926-6	2003	These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation.	Lysine	52-58	ubiquitin conjugating enzyme E2 N	Homo sapiens	92-97
12591926-6	2003	These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation.	Lysine	52-58	ubiquitin conjugating enzyme E2 V1	Homo sapiens	98-103
12640139-4	2003	In SREBP1a, the acetylated lysine residue resides in the DNA-binding domain of the protein.	Lysine	27-33	sterol regulatory element binding transcription factor 1	Homo sapiens	3-10
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Lysine	231-234	neurotensin	Bos taurus	41-52
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Lysine	231-234	neurotensin	Bos taurus	54-56
12640139-6	2003	Indeed, acetylation or mutation of the acetylated lysine residue in SREBP1a stabilizes the protein.	Lysine	50-56	sterol regulatory element binding transcription factor 1	Homo sapiens	68-75
28915556-3	2017	Here we report biological significance of SMYD2-mediated lysine 133 (K133) methylation of beta-catenin on its nuclear translocation.	Lysine	57-63	catenin beta 1	Homo sapiens	90-102
6830036-2	1983	These same smoke components also suppress lysyl-oxidase-catalyzed oxidation of lysine epsilon-amino groups in tropoelastin (the chemical step preceding formation of all elastin cross-links, including desmosine) in a dose-dependent fashion.	Lysine	79-85	elastin	Homo sapiens	110-122
6830036-2	1983	These same smoke components also suppress lysyl-oxidase-catalyzed oxidation of lysine epsilon-amino groups in tropoelastin (the chemical step preceding formation of all elastin cross-links, including desmosine) in a dose-dependent fashion.	Lysine	79-85	elastin	Homo sapiens	115-122
28640323-0	2017	Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.	Lysine	0-3	thrombomodulin	Homo sapiens	80-94
28740167-6	2017	Importantly, mutating lysine 896 in CtIP recapitulates the CBX4-depletion phenotype, blocks homologous recombination and increases genomic instability.	Lysine	22-28	chromobox 4	Homo sapiens	59-63
6131444-2	1982	This synthesis involves the linkage of Boc-Phe-D-Trp-Lys[Z(pCl)]-Thr-Phe-Thr-Ser-OH to H-Hcy(CH2-CO-Lys[Z(oCl)]-Asn-Phe-OMe)-NH2 and subsequent azide cyclization.	Lysine	53-56	BOC cell adhesion associated, oncogene regulated	Rattus norvegicus	39-42
12529320-3	2003	To test this hypothesis, we have constructed several mutants of TM456 and protein C in which charges of the putative interacting residues on both TM4 (Asp/Glu) and protein C (Lys/Arg) have been reversed.	Lysine	175-178	thrombomodulin	Homo sapiens	64-69
28903417-5	2017	This ERCC1 region was modified by non-conventional lysine-independent, but proteasome-dependent polyubiquitination, involving Lys33 of ubiquitin and a linear ubiquitin chain.	Lysine	51-57	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	5-10
12651889-3	2003	We identify three lysines that are acetylated in vivo, and demonstrate their essential requirement for proper nuclear localization and biological activity of POP-1 during C. elegans embryogenesis.	Lysine	18-25	Protein pop-1	Caenorhabditis elegans	158-163
7140740-6	1982	Subunits A and B from aminopeptidase prepared in the presence of aprotinin contained both N-terminal lysine and alanine, whereas N-terminal alanine and glycine were found for both of these subunits from the other amphiphilic form.	Lysine	101-107	alanyl aminopeptidase, membrane	Sus scrofa	22-36
12609853-1	2003	Alamethicin K18 is a covalently linked alamethicin dimer in which the glutamine residue at position 18 in each helix has been replaced by a lysine residue.	Lysine	140-146	keratin 18	Homo sapiens	12-15
28619824-2	2017	Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b.	Lysine	10-16	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	167-171
12571358-3	2003	First, we performed histone deacetylation assays and found that dSir2 deacetylates a broad range of acetylated lysine residues.	Lysine	111-117	Sirtuin 1	Drosophila melanogaster	64-69
6922013-5	1982	7000, high lysine content) suppressed the activity of a labile form of kallikrein and prevented activation of prekallikrein.	Lysine	11-17	kallikrein related peptidase 4	Homo sapiens	71-81
7046788-7	1982	kallikrein prefer substrates containing arginine side chains; h. urokinase prefers substrate containing lysine.	Lysine	104-110	kallikrein related peptidase 4	Homo sapiens	0-10
28619824-2	2017	Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b.	Lysine	10-16	SET domain containing 1A	Mus musculus	183-189
6279643-9	1982	On the basis of amino acid composition, the tryptic peptides carrying the minor phosphorylation sites were identified as H-Leu-Ser(P)-Ala-Lys representing residues 23-26 and 27-30 of HMG 14 and HMG 17, respectively.	Lysine	138-141	high mobility group nucleosomal binding domain 2	Homo sapiens	194-200
28299531-5	2017	Mass spectrometric studies revealed formation of glyoxal-derived fluorescent AGE adduct pentosidine between Lys-145 and Arg-139 residues of Mb.	Lysine	108-111	myoglobin	Homo sapiens	140-142
7197163-9	1981	The cross-link, lysylnorleucine, may be evidence of covalent bonding of glycoprotein to elastin, explaining my inability to obtain the biopolymer elastin with the composition of tropoelastin corrected for the desmosine-lysine content.	Lysine	219-225	elastin	Homo sapiens	88-95
6115672-3	1981	This report describes various assay procedures for lysyl oxidase, the enzyme responsible for deaminating lysine residues to give aldehyde cross-link precursors, in culture medium from these cells.	Lysine	105-111	protein-lysine 6-oxidase	Oryctolagus cuniculus	51-64
12581743-1	2003	Eukaryotic initiation factor 2 (eIF2)-associated glycoprotein, p67, has protection of eIF2alpha phosphorylation (POEP) activity, and this activity requires lysine-rich domains I and II of p67.	Lysine	156-162	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	0-30
12581743-1	2003	Eukaryotic initiation factor 2 (eIF2)-associated glycoprotein, p67, has protection of eIF2alpha phosphorylation (POEP) activity, and this activity requires lysine-rich domains I and II of p67.	Lysine	156-162	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	32-36
12427740-6	2003	We asked if MeCP2 can deliver Lys(9) H3 methylation to the H19 gene, whose activity it represses.	Lysine	30-33	H19 imprinted maternally expressed transcript	Homo sapiens	59-62
28978082-3	2017	A number of epi-sensitised pathways, including sonic hedgehog (SHH), were identified in AML cells by integration of global patterns of histone H3 lysine 9 (H3K9) acetylation with transcriptomic analysis following Vorinostat-treatment.	Lysine	146-152	sonic hedgehog signaling molecule	Homo sapiens	47-61
6912069-3	1981	These cross-linking residues are formed by the action of lysyl oxidase upon Lys residues in tropoelastin, a precursor of elastin.	Lysine	76-79	elastin	Homo sapiens	92-104
6912069-3	1981	These cross-linking residues are formed by the action of lysyl oxidase upon Lys residues in tropoelastin, a precursor of elastin.	Lysine	76-79	elastin	Homo sapiens	97-104
28978082-3	2017	A number of epi-sensitised pathways, including sonic hedgehog (SHH), were identified in AML cells by integration of global patterns of histone H3 lysine 9 (H3K9) acetylation with transcriptomic analysis following Vorinostat-treatment.	Lysine	146-152	sonic hedgehog signaling molecule	Homo sapiens	63-66
28671020-0	2017	The Wnt/beta-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation.	Lysine	115-121	catenin beta 1	Homo sapiens	8-20
7214367-5	1981	The histone H3 fraction, poly-L-lysine and poly-L-arginine, inhibited induction of differentiation of M1 cells.	Lysine	25-38	H3 clustered histone 7	Mus musculus	4-14
6257307-1	1980	The reaction between ferrocytochrome c and yeast cytochrome c peroxidase was studied using cytochrome c derivatives specifically trifluoroacetylated at single lysine amino groups.	Lysine	159-165	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	49-72
12565857-1	2003	Heterochromatin protein 1 (HP1) binds to the nucleosome via a methylated lysine residue 9 of histone H3 which is catalyzed by a histone methyltransferase such as SUV39H1.	Lysine	73-79	suppressor of variegation 3-9 1	Mus musculus	162-169
28671020-0	2017	The Wnt/beta-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation.	Lysine	115-121	IL2 inducible T cell kinase	Homo sapiens	61-64
28300602-4	2017	The Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain is an emerging reader module that selectively recognizes histone lysine acylation with a preference for crotonylation over acetylation.	Lysine	112-118	MLLT1 super elongation complex subunit	Homo sapiens	10-13
12459551-0	2003	The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.	Lysine	176-179	suppressor of cytokine signaling 3	Mus musculus	36-41
12459551-4	2003	A potential ubiquitination residue, Lys-6, at the N terminus is evolutionary conserved among SOCS3 species.	Lysine	36-39	suppressor of cytokine signaling 3	Mus musculus	93-98
12459551-8	2003	These observations suggest that the short form of SOCS3 is a naturally occurring stabilized inhibitory protein, whereas WT-SOCS3 is a short-lived protein modulated by Lys-6 ubiquitination and proteasome-dependent degradation.	Lysine	167-170	suppressor of cytokine signaling 3	Mus musculus	123-128
6768856-3	1980	The opaque-2 (o2) gene increases the lysine and tryptophan contents of maize and its protein quality; the sugary-2 (su2) gene improves vitreousness and density but decreases lysine; the double-mutant surgery-2 opaque-2 (su2o2) has the improved kernel characteristics and an even higher protein quality than opaque-2.	Lysine	37-43	regulatory protein opaque-2	Zea mays	4-12
28428253-4	2017	Here we address catalytic necessity for the first time, using the prototypic invertebrate representative twitchin (UNC-22) from Caenorhabditis elegans In in vitro experiments, change of a conserved lysine (K) that is involved in ATP coordination to alanine (A) resulted in elimination of kinase activity without affecting the overall structure of the kinase domain.	Lysine	198-204	Twitchin	Caenorhabditis elegans	105-113
6247646-2	1980	Cytochrome c is modified by covalent binding of pyridoxal phosphate (PLP) to lysine residues.	Lysine	77-83	proteolipid protein 1	Homo sapiens	69-72
6769804-7	1980	However, the levels of transferrin found in the peritoneal exudates were lower in mice fed the isoleucine- or lysine-limited diets than in mice fed the control diet.	Lysine	110-116	transferrin	Mus musculus	23-34
12397066-6	2003	Addition of a 6x Myc tag to the N terminus of MyoD can force degradation through the lysine-dependent pathway by preventing ubiquitination at the N-terminal site.	Lysine	85-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-20
12514135-0	2003	Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.	Lysine	21-27	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	73-79
28428253-4	2017	Here we address catalytic necessity for the first time, using the prototypic invertebrate representative twitchin (UNC-22) from Caenorhabditis elegans In in vitro experiments, change of a conserved lysine (K) that is involved in ATP coordination to alanine (A) resulted in elimination of kinase activity without affecting the overall structure of the kinase domain.	Lysine	198-204	Twitchin	Caenorhabditis elegans	115-121
6450664-3	1980	The eggshell membrane protein has approximately 10 times the level of lysine-derived aldehyde found in elastin.	Lysine	70-76	elastin	Homo sapiens	103-110
28481080-7	2017	Using conventional peptide chemistry, a PTPmu-targeted peptide was linked to a chelator that had been conjugated to a lysine residue.	Lysine	118-124	protein tyrosine phosphatase receptor type M	Homo sapiens	40-45
117548-3	1979	An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally.	Lysine	27-33	immunoglobulin heavy constant gamma 2B	Mus musculus	77-85
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	206-209	mutL homolog 1	Homo sapiens	74-78
12559117-4	2003	In particular, the mGluR1 antagonist LY 367385, as well as the mGluR5 antagonist MPEP, reduce LTP amplitude.	Lysine	37-39	glutamate receptor, metabotropic 1	Mus musculus	19-25
28188179-1	2017	Jmjd3 and Utx are demethylases specific for lysine 27 of histone H3.	Lysine	44-50	lysine (K)-specific demethylase 6A	Mus musculus	10-13
12559117-5	2003	Moreover, blockade of both mGluR1 and mGluR5 by LY 367385 and MPEP co-administration fully suppresses LTP.	Lysine	48-50	glutamate receptor, metabotropic 1	Mus musculus	27-33
12496069-10	2002	A "hot-spot" epitope residue Lys-97 forms an intermolecular salt bridge in HH8-HEL, and participates in the intermolecular pentad in the HH26-HEL complex.	Lysine	29-32	KISS1 receptor	Homo sapiens	75-78
157166-0	1979	On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen.	Lysine	40-46	serpin family F member 2	Homo sapiens	99-117
157166-1	1979	Plasminogen and plasminogen derivatives which contain lysine-binding sites were found to decrease the reaction rate between plasmin and alpha2-antiplasmin by competing with plasmin for the complementary site(s) in alpha2-antiplasmin.	Lysine	54-60	serpin family F member 2	Homo sapiens	136-154
157166-1	1979	Plasminogen and plasminogen derivatives which contain lysine-binding sites were found to decrease the reaction rate between plasmin and alpha2-antiplasmin by competing with plasmin for the complementary site(s) in alpha2-antiplasmin.	Lysine	54-60	serpin family F member 2	Homo sapiens	214-232
157166-3	1979	The lysine-binding site(s) which is situated in triple-loops 1--3 in the plasmin A-chain is mainly responsible for the interaction with alpha2-antiplasmin.	Lysine	4-10	serpin family F member 2	Homo sapiens	136-154
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	serpin family F member 2	Homo sapiens	138-156
157166-5	1979	Fibrinogen, fibrinogen digested with plasmin, purified fragment E and purified fragment D interfere with the reaction between plasmin and alpha2-antiplasmin by competing with alpha2-antiplasmin for the lysine-binding site(s) in the plasmin A-chain.	Lysine	202-208	serpin family F member 2	Homo sapiens	175-193
225173-9	1979	The rate and extent of lysine incorporation, however, was higher with tRNA2Lys than with tRNA3Lys, in agreement with the fact that alpha-globin and beta-globin mRNAs contain more A-A-G than A-A-A- codons for lysine.	Lysine	23-29	hemoglobin subunit beta-1/2	Oryctolagus cuniculus	148-159
28201649-3	2017	We identify a non-canonical SUMOylation motif termed pSuM that conjugates SUMO2 at Lys-325 of FXR under the direct control of casein kinase 2 (CK2), which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327.	Lysine	83-86	protein inhibitor of activated STAT 1	Homo sapiens	206-211
88735-3	1979	At the position corresponding to amino acid 17, replacement of an adenine by a uracil changes the triplet AAG, which codes for lysine in the normal beta chain, to an amber termination codon, UAG.	Lysine	127-133	N-methylpurine DNA glycosylase	Homo sapiens	106-109
28377500-3	2017	Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is regulated by proteolytic cleavage and Lys-63-polyubiquitination.	Lysine	118-121	receptor interacting serine/threonine kinase 1	Homo sapiens	67-71
23105165-10	2002	Thus, the residue Lys(280) (6.55), which is located within the upper third of TM 6 of the human P2Y(1) receptor, is not only critical for the activation of the receptor but also plays an important role in the binding of pyridoxal derivatives and a number of other chemically unrelated P2 receptor antagonists.	Lysine	18-21	purinergic receptor P2Y1	Homo sapiens	96-111
28377500-5	2017	Here, we demonstrate that Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.	Lysine	41-44	Death-associated inhibitor of apoptosis 2	Drosophila melanogaster	197-202
697732-6	1978	The desensitization of alkylated liver alcohol dehydrogenase to substrate inhibition is identified with a decrease in inhibitory Michaelis constants for alcohols and this is favoured by the steric effects of substituents at the lysine residues.	Lysine	228-234	aldo-keto reductase family 1 member A1	Homo sapiens	39-60
29029401-0	2017	Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress.	Lysine	0-6	flap structure-specific endonuclease 1	Homo sapiens	22-26
17269-6	1977	When intact elastin is photolysed for 20 minutes in water, approximately 75% of the (iso) desmosines are destroyed, accompanied by an increase of free lysine residues.	Lysine	151-157	elastin	Homo sapiens	12-19
12453439-0	2002	Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells.	Lysine	70-76	annexin A2	Bos taurus	47-57
12453439-20	2002	Epsilon-aminocaproic acid, a lys analogue, effectively blocks angiostatin and annexin II interaction, indicating that the lysine-binding domain of AS is required for binding to annexin II.	Lysine	122-128	annexin A2	Bos taurus	78-88
12453439-20	2002	Epsilon-aminocaproic acid, a lys analogue, effectively blocks angiostatin and annexin II interaction, indicating that the lysine-binding domain of AS is required for binding to annexin II.	Lysine	122-128	annexin A2	Bos taurus	177-187
29029401-0	2017	Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress.	Lysine	0-6	KMT5A pseudogene 1	Homo sapiens	30-34
29029401-4	2017	To define addition substrates of SET7 involved in the DDR, we screened a peptide array encompassing potential lysine methylation sites from &gt;100 key DDR proteins and identified peptides from 58 proteins to be lysine methylated defining a methylation consensus sequence of [S&gt;K-2; S&gt;R-1; K0] consistent with previous findings.	Lysine	110-116	KMT5A pseudogene 1	Homo sapiens	33-37
12429091-1	2002	Cocrystal structures of Methanococcus jannaschii diaminopimelate decarboxylase (DAPDC) bound to a substrate analog, azelaic acid, and its L-lysine product have been determined at 2.6 A and 2.0 A, respectively.	Lysine	138-146	AT695_RS10575	Staphylococcus aureus	49-78
29029401-4	2017	To define addition substrates of SET7 involved in the DDR, we screened a peptide array encompassing potential lysine methylation sites from &gt;100 key DDR proteins and identified peptides from 58 proteins to be lysine methylated defining a methylation consensus sequence of [S&gt;K-2; S&gt;R-1; K0] consistent with previous findings.	Lysine	212-218	KMT5A pseudogene 1	Homo sapiens	33-37
12698553-3	2002	Significant similarity of amino acid sequences of proteases Lon and repressors LexA in the regions including the catalytic serine and lysine residues is revealed by comparing primary structures of different families of the enzymes with Ser-Lys catalytic dyad.	Lysine	134-140	lon peptidase 1, mitochondrial	Homo sapiens	60-63
1200153-7	1975	Insulin, on the other hand, appeared to have a lipogenic effect on adipose tissue and to stimulate directly the uptake of valine, isoleucine, leucine, tyrosine, lysine, and alanine only at extrahepatic sites.	Lysine	161-167	LOC105613195	Ovis aries	0-7
12698553-3	2002	Significant similarity of amino acid sequences of proteases Lon and repressors LexA in the regions including the catalytic serine and lysine residues is revealed by comparing primary structures of different families of the enzymes with Ser-Lys catalytic dyad.	Lysine	240-243	lon peptidase 1, mitochondrial	Homo sapiens	60-63
28509866-7	2017	Furthermore, HDAC8 induced tri-methylation of histone H3 lysine 27 (H3K27me3), which is known to suppress PTEN expression, through at least in part down-regulating the H3K27me3 eraser Jumonji Domain Containing (JMJD) 3.	Lysine	57-63	histone deacetylase 8	Homo sapiens	13-18
28509866-7	2017	Furthermore, HDAC8 induced tri-methylation of histone H3 lysine 27 (H3K27me3), which is known to suppress PTEN expression, through at least in part down-regulating the H3K27me3 eraser Jumonji Domain Containing (JMJD) 3.	Lysine	57-63	phosphatase and tensin homolog	Homo sapiens	106-110
12145316-7	2002	Mutational analysis identified five of these residues (Lys-227, Asn-231, Asn-278, Lys-308, and Arg-312) as essential for Hsp90 binding.	Lysine	55-58	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	121-126
12145316-7	2002	Mutational analysis identified five of these residues (Lys-227, Asn-231, Asn-278, Lys-308, and Arg-312) as essential for Hsp90 binding.	Lysine	82-85	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	121-126
235536-8	1975	Acetylation of retinol-RBP with 10-fold molar excess of N-acetylimidazole over tyrosine resulted in the acetylation of all lysine residues and in the acetylation of 0.9 to 1.3 tyrosyl residues per molecule (out of eight).	Lysine	123-129	retinol binding protein 4	Homo sapiens	23-26
235536-9	1975	Acetylation of retinol-RBP, APO-RBP, and retinol-RBP-prealbumin complex with 50-fold molar excess of N-acetylimidazole resulted, again, with all of the lysine residues being acetylated and between 1.8 and 2.8 tyrosyl residues per molecule being acetylated.	Lysine	152-158	retinol binding protein 4	Homo sapiens	23-26
235536-9	1975	Acetylation of retinol-RBP, APO-RBP, and retinol-RBP-prealbumin complex with 50-fold molar excess of N-acetylimidazole resulted, again, with all of the lysine residues being acetylated and between 1.8 and 2.8 tyrosyl residues per molecule being acetylated.	Lysine	152-158	retinol binding protein 4	Homo sapiens	32-35
235536-9	1975	Acetylation of retinol-RBP, APO-RBP, and retinol-RBP-prealbumin complex with 50-fold molar excess of N-acetylimidazole resulted, again, with all of the lysine residues being acetylated and between 1.8 and 2.8 tyrosyl residues per molecule being acetylated.	Lysine	152-158	retinol binding protein 4	Homo sapiens	32-35
27358484-4	2017	Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis.	Lysine	45-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
1125272-0	1975	Some lysine-containing peptides from the elastase digest of elastin and their relation to lysinonorleucine cross-link.	Lysine	5-11	elastin	Homo sapiens	60-67
12145316-8	2002	The other two residues (Phe-234 and Ser-274) and another three TPR domain residues not definitively associated with the binding groove (Leu-284, Lys-285, and Asp-329) are required for efficient Hsp90 binding.	Lysine	145-148	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	194-199
28447683-3	2017	Incorporation of a lysine-rich tag derived from the silaffin R5 peptide into the N-terminus of a hydrophilic ELP that self-assembles upon conjugation of hydrophobic molecules at the C-terminus results in the formation of spherical micelles with a conjugated drug embedded in the core and a corona that is decorated with the silaffin peptide.	Lysine	19-25	nuclear receptor subfamily 5 group A member 1	Homo sapiens	109-112
12133841-3	2002	This structure provides the molecular basis for identifying the major determinants of the BgK-Kv1.1 channel interactions involving the BgK dyad residues Lys(25) and Tyr(26).	Lysine	153-156	potassium voltage-gated channel subfamily A member 1	Homo sapiens	94-99
12133841-4	2002	These interactions are (i) electrostatic interactions between the extremity of Lys(25) side chain and carbonyl oxygen atoms of residues from the channel selectivity filter that may be strengthened by solvent exclusion provided by (ii) hydrophobic interactions involving BgK residues Tyr(26) and Phe(6) and Kv1.1 residue Tyr(379) whose side chain protrudes in the channel vestibule.	Lysine	79-82	potassium voltage-gated channel subfamily A member 1	Homo sapiens	306-311
12242305-3	2002	Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase.	Lysine	137-144	histone deacetylase 4	Homo sapiens	26-31
12242305-3	2002	Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase.	Lysine	137-144	chromobox 5	Homo sapiens	58-83
4376128-0	1974	Studies on ribonuclease S": the role of lysine-7 for activation of S-protein.	Lysine	40-46	vitronectin	Homo sapiens	67-76
24419545-3	1974	On the other hand, percent lysine in the whole kernel, lysine yield per hectare and percent lysine in protein are increased by 53, 45 and 55 percent, respectively, in the o 2 inbred lines and hybrids compared with their normal analogues.	Lysine	55-61	regulatory protein opaque-2	Zea mays	171-174
12242305-3	2002	Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase.	Lysine	137-144	chromobox 5	Homo sapiens	85-88
28298444-4	2017	Here we show that GSK3beta is degraded by the ubiquitin-proteasome pathway in murine lung epithelial cells through lysine 183 as an acceptor site for K48 polyubiquitination.	Lysine	115-121	glycogen synthase kinase 3 beta	Mus musculus	18-26
12242305-5	2002	Since the histone methyl-lysine residues recognized by HP1 also serve as substrates for deacetylation by HDACs, the interaction of MITR and HDACs with HP1 provides an efficient mechanism for silencing MEF2 target genes by coupling histone deacetylation and methylation.	Lysine	25-31	chromobox 5	Homo sapiens	55-58
4774398-1	1973	The enzymes involved in the initial degradative steps of lysine metabolism, lysine-2-oxoglutarate reductase and saccharopine dehydrogenase, were studied and their activities in different mammals compared.	Lysine	57-63	aminoadipate-semialdehyde synthase	Homo sapiens	76-107
12082110-6	2002	Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1.	Lysine	96-99	serpin family E member 1	Homo sapiens	134-139
28302719-3	2017	Here we found that enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 lysine 27 at the promoter of the 11beta-HSD2 gene.	Lysine	138-144	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	82-93
12082110-6	2002	Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1.	Lysine	96-99	serpin family E member 1	Homo sapiens	134-139
12082110-6	2002	Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1.	Lysine	96-99	serpin family E member 1	Homo sapiens	134-139
12082110-8	2002	Taken together, our data indicate that the peptide Gly(486)-Lys(502) derived from domain 5 of HKa serves to interfere with PAI-1 function.	Lysine	60-63	serpin family E member 1	Homo sapiens	123-128
28302719-3	2017	Here we found that enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 lysine 27 at the promoter of the 11beta-HSD2 gene.	Lysine	138-144	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	171-182
5097573-9	1971	In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly.	Lysine	142-148	elastin	Homo sapiens	3-10
28302719-5	2017	As a result of inactivation of the pRB-E2F1-EZH2 pathway, the repressive marker trimethylation of histone H3 lysine 27 at the 11beta-HSD2 promoter is removed, which leads to the robust expression of 11beta-HSD2 during syncytialization.	Lysine	109-115	E2F transcription factor 1	Homo sapiens	39-43
28302719-5	2017	As a result of inactivation of the pRB-E2F1-EZH2 pathway, the repressive marker trimethylation of histone H3 lysine 27 at the 11beta-HSD2 promoter is removed, which leads to the robust expression of 11beta-HSD2 during syncytialization.	Lysine	109-115	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	126-137
5289018-4	1970	Comparison of the sequences of glutamate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase has indicated that only two 12-residue sequences are similar in the two enzymes; this sequence includes reactive lysine-97 of the former enzyme.	Lysine	213-219	LOC786101	Bos taurus	59-99
28302719-5	2017	As a result of inactivation of the pRB-E2F1-EZH2 pathway, the repressive marker trimethylation of histone H3 lysine 27 at the 11beta-HSD2 promoter is removed, which leads to the robust expression of 11beta-HSD2 during syncytialization.	Lysine	109-115	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	199-210
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	104-110	structural maintenance of chromosomes 1A	Homo sapiens	241-245
5659685-2	1968	It had been shown that beta-aminopropionitrile blocks the cross-linkage of elastin and collagen by preventing the initial step in cross-linkage: the conversion of lysine in peptide linkage to alpha-amino adipic-delta-semialdehyde.	Lysine	163-169	elastin	Homo sapiens	75-82
12181125-1	2002	DeltaKPQ, a three amino acid [lysine (K), proline (P), glutamine (Q)] deletion mutation of the human cardiac Na channel (hH1), which is one cause of long QT syndrome (LQT3), has impaired inactivation resulting in a late sodium current.	Lysine	30-36	H1.5 linker histone, cluster member	Homo sapiens	121-124
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	194-200	structural maintenance of chromosomes 1A	Homo sapiens	241-245
28274822-10	2017	Consistently, the acetylation of histone 3 on Lys 9 (H3K9) and histone 4 on Lys12 (H4K12) increased significantly in the promoter region of Bdnf exon IV.	Lysine	46-49	brain derived neurotrophic factor	Mus musculus	140-144
12176868-8	2002	Molecular modeling suggests that these S-domains are likely to interact with basic residues Arg 17, Arg 45, and Arg 47 and possibly with Lys 44 on MIP1alpha and that the interconnecting N-acetylated region is of sufficient length to allow the 2 S-domains to bind to these sites on opposite faces of the dimer.	Lysine	137-140	C-C motif chemokine ligand 3	Homo sapiens	147-156
5928905-0	1966	The incorporation of lysine into growing elastin.	Lysine	21-27	elastin	Homo sapiens	41-48
5920244-0	1966	Incorporation of labelled lysine into the desmosine cross-bridges in elastin.	Lysine	26-32	elastin	Homo sapiens	69-76
28553408-9	2017	Interestingly, we revealed that the amino acid residues of Sec23a joined to ubiquitin were cysteine instead of the conventional lysine residues.	Lysine	128-134	SEC23 homolog A, COPII coat complex component	Homo sapiens	59-65
5957133-0	1966	Purification of a mammalian peptidase selective for N-terminal arginine and lysine residues: aminopeptidase B.	Lysine	76-82	arginyl aminopeptidase	Homo sapiens	93-109
12068020-2	2002	The epitope for thrombomodulin binding is shaped as a hot spot in exosite I, centered around the buried ion quartet formed by Arg(67), Lys(70), Glu(77), and Glu(80), and capped by the hydrophobic residues Tyr(76) and Ile(82).	Lysine	135-138	thrombomodulin	Homo sapiens	16-30
12060650-1	2002	Heterochromatin protein 1 (HP1) controls heterochromatin formation in animal cells, at least partly through interaction with lysine 9 (Lys-9)-methylated histone H3.	Lysine	125-131	chromobox 5	Homo sapiens	0-25
12060650-1	2002	Heterochromatin protein 1 (HP1) controls heterochromatin formation in animal cells, at least partly through interaction with lysine 9 (Lys-9)-methylated histone H3.	Lysine	125-131	chromobox 5	Homo sapiens	27-30
12060650-1	2002	Heterochromatin protein 1 (HP1) controls heterochromatin formation in animal cells, at least partly through interaction with lysine 9 (Lys-9)-methylated histone H3.	Lysine	135-138	chromobox 5	Homo sapiens	0-25
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	Zic family member 1	Sus scrofa	283-287
12060650-1	2002	Heterochromatin protein 1 (HP1) controls heterochromatin formation in animal cells, at least partly through interaction with lysine 9 (Lys-9)-methylated histone H3.	Lysine	135-138	chromobox 5	Homo sapiens	27-30
5862977-0	1964	The utilization of lysine in the biosynthesis of elastin crosslinks.	Lysine	19-25	elastin	Homo sapiens	49-56
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	myogenic differentiation 1	Mus musculus	57-61
14203176-1	1964	HYDROLYSIS BY TRYPSIN, PAPAIN AND CATHEPSIN B OF SUBSTRATES CONTAINING LYSINE, 4-THIALYSINE OR 4-OXALYSINE.	Lysine	71-77	cathepsin B	Homo sapiens	34-45
12186852-1	2002	The COOH-terminal tail of mammalian neurofilament heavy subunit (NF-H), the largest neurofilament subunit, contains 44-51 lysine-serine-proline repeats that are nearly stoichiometrically phosphorylated after assembly into neurofilaments in axons.	Lysine	122-128	neurofilament, heavy polypeptide	Mus musculus	36-63
12186852-1	2002	The COOH-terminal tail of mammalian neurofilament heavy subunit (NF-H), the largest neurofilament subunit, contains 44-51 lysine-serine-proline repeats that are nearly stoichiometrically phosphorylated after assembly into neurofilaments in axons.	Lysine	122-128	neurofilament heavy chain	Homo sapiens	65-69
12060666-5	2002	Likewise, Lys-731 and Lys-788 mutants of GRIP1 have attenuated ability to enhance AR-dependent transcription and fail to synergize with PIASx beta-mediated activation of AR function, indicating that sumoylation modifies the ability of GRIP1 to function as a steroid receptor coactivator.	Lysine	22-25	glutamate receptor interacting protein 1	Homo sapiens	41-46
12060666-6	2002	The Lys-731 sumoylation site is conserved in SRC-3 and SRC-1, and the NIDs of the latter coactivators harbor one or two additional sites matching with the consensus sites for SUMO-1 attachment, respectively, suggesting a more general role for the modification in the regulation of SRC protein activity.	Lysine	4-7	nuclear receptor coactivator 3	Homo sapiens	45-50
34007332-2	2021	Lysine demethylase 2A (KDM2A), a Jumonji C domain-containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues.	Lysine	107-113	lysine demethylase 2A	Homo sapiens	0-21
34007332-2	2021	Lysine demethylase 2A (KDM2A), a Jumonji C domain-containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues.	Lysine	107-113	lysine demethylase 2A	Homo sapiens	23-28
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	myogenic differentiation 1	Mus musculus	160-164
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	myogenic differentiation 1	Mus musculus	160-164
33965786-6	2021	Zebrafish Prss59.1 showed the highest activity against Lys-MCA.	Lysine	55-58	serine protease 59, tandem duplicate 1	Danio rerio	10-18
28351977-3	2017	Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, and the Deltex2 knockout phenotype can be rescued by a loss-of-function allele for MyoD In addition, we obtained evidence that Deltex2 regulates MyoD expression by promoting the enrichment of histone 3 modified by dimethylation at lysine 9 at a key regulatory region of the MyoD locus.	Lysine	308-314	myogenic differentiation 1	Mus musculus	160-164
27899633-6	2017	Mechanistically, we showed that the enzymatic activity of JMJD6 was required for a subset of JMJD6-regulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternative splicing.	Lysine	138-144	jumonji domain containing 6	Mus musculus	58-63
33848640-8	2021	We chose to follow-up on Mortality factor 4-like 1 (MORF4L1), which was significantly decreased in ubiquitylation at lysine 187 and lysine 104 upon proteasome inhibition, but increased in protein abundance by approximately two-fold.	Lysine	117-123	mortality factor 4 like 1	Homo sapiens	25-50
33848640-8	2021	We chose to follow-up on Mortality factor 4-like 1 (MORF4L1), which was significantly decreased in ubiquitylation at lysine 187 and lysine 104 upon proteasome inhibition, but increased in protein abundance by approximately two-fold.	Lysine	117-123	mortality factor 4 like 1	Homo sapiens	52-59
33848640-8	2021	We chose to follow-up on Mortality factor 4-like 1 (MORF4L1), which was significantly decreased in ubiquitylation at lysine 187 and lysine 104 upon proteasome inhibition, but increased in protein abundance by approximately two-fold.	Lysine	132-138	mortality factor 4 like 1	Homo sapiens	25-50
33848640-8	2021	We chose to follow-up on Mortality factor 4-like 1 (MORF4L1), which was significantly decreased in ubiquitylation at lysine 187 and lysine 104 upon proteasome inhibition, but increased in protein abundance by approximately two-fold.	Lysine	132-138	mortality factor 4 like 1	Homo sapiens	52-59
12202215-0	2002	Lysine-independent ubiquitination of Epstein-Barr virus LMP2A.	Lysine	0-6	LMP2A	Human gammaherpesvirus 4	56-61
12070136-10	2002	By analyzing approximately 4800 mutant strains, each deleted for a different non-essential gene, we discovered that the ubiquitin-conjugating enzyme Rad6 is required for methylation of lysine 4 of histone H3.	Lysine	185-191	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	149-153
27899633-6	2017	Mechanistically, we showed that the enzymatic activity of JMJD6 was required for a subset of JMJD6-regulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternative splicing.	Lysine	138-144	jumonji domain containing 6	Mus musculus	93-98
12142119-5	2002	Deoxyribonucleic acid samples were genotyped for the nucleotide 2690A&gt;C variation of the HERG gene, corresponding to the HERG K(lysine)897T(threonine) amino acid polymorphism.	Lysine	131-137	potassium voltage-gated channel subfamily H member 2	Homo sapiens	92-96
27899633-6	2017	Mechanistically, we showed that the enzymatic activity of JMJD6 was required for a subset of JMJD6-regulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternative splicing.	Lysine	138-144	jumonji domain containing 6	Mus musculus	93-98
12142119-5	2002	Deoxyribonucleic acid samples were genotyped for the nucleotide 2690A&gt;C variation of the HERG gene, corresponding to the HERG K(lysine)897T(threonine) amino acid polymorphism.	Lysine	131-137	potassium voltage-gated channel subfamily H member 2	Homo sapiens	124-128
27899633-6	2017	Mechanistically, we showed that the enzymatic activity of JMJD6 was required for a subset of JMJD6-regulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least partially, their co-regulated alternative splicing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternative splicing.	Lysine	138-144	jumonji domain containing 6	Mus musculus	93-98
33838133-7	2021	In general, there were two pathways confirmed using tissues and cells: 1) Increased histone deacetylase sirtuin 7 (SIRT7) mediated loss of histone 3 lysine 18 acetylation (H3K18ac) at the promoter of OAT2 and inhibited its transcription.	Lysine	149-155	sirtuin 7	Homo sapiens	115-120
28180293-1	2017	Rad6 and Bre1, ubiquitin-conjugating E2 and E3 enzymes respectively, are responsible for histone H2B lysine 123 mono-ubiquitination (H2Bub1) in Saccharomyces cerevisiae.	Lysine	101-107	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	0-4
12130679-7	2002	On the other hand, coupling of B2R is absolutely dependent on a membrane-proximal epitope in the C-terminal domain upstream from Lys(315).	Lysine	129-132	bradykinin receptor B2	Homo sapiens	31-34
11973335-4	2002	We show that the CBP-mediated acetylation of beta-catenin occurs at a single site, lysine 49.	Lysine	83-89	catenin beta 1	Homo sapiens	45-57
33494958-3	2021	PRC2-catalyzed histone H3 lysine 27 trimethylation (H3K27me3) is recognized by distinct classes of effectors such as canonical PRC1 and BAH module-containing proteins (notably BAHCC1 in human).	Lysine	26-32	BAH domain and coiled-coil containing 1	Homo sapiens	176-182
28380376-3	2017	Using a combination of phylogenetics, structural biology, and enzymology, we show that SIRT4 removes three acyl moieties from lysine residues: methylglutaryl (MG)-, hydroxymethylglutaryl (HMG)-, and 3-methylglutaconyl (MGc)-lysine.	Lysine	126-132	sirtuin 4	Mus musculus	87-92
34031939-11	2021	Downregulation of KLF14 in activated HSCs was mediated by EZH2-regulated histone H3 lysine 27 trimethylation.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	58-62
34006303-10	2021	Mechanistically, KDM6A promotes the transcription of ARHGDIB by demethylating histone H3 lysine di/trimethylation (H3K27me2/3) and consequently leads to inhibition of Rac1.	Lysine	89-95	Rho, GDP dissociation inhibitor (GDI) beta	Mus musculus	53-60
11973335-5	2002	Importantly, this lysine is frequently found mutated in cancer and is in a region of importance to the regulation of beta-catenin.	Lysine	18-24	catenin beta 1	Homo sapiens	117-129
12161073-3	2002	One residue, Lys 125, is pivotal for antithrombin to recognize and bind the nonreducing-end trisaccharide of the pentasaccharide in an initial low-affinity complex.	Lysine	13-16	serpin family C member 1	Homo sapiens	37-49
28380376-3	2017	Using a combination of phylogenetics, structural biology, and enzymology, we show that SIRT4 removes three acyl moieties from lysine residues: methylglutaryl (MG)-, hydroxymethylglutaryl (HMG)-, and 3-methylglutaconyl (MGc)-lysine.	Lysine	224-230	sirtuin 4	Mus musculus	87-92
28216155-6	2017	Promoter analysis and quantitative ChIP analysis demonstrated that FOG1-mediated transcriptional repression of PU.1 would be mediated through a GATA-binding element located at its promoter, accompanied by significantly decreased H3 acetylation at lysine 4 and 9 (K4 and K9) as well as H3K4 trimethylation.	Lysine	247-253	Spi-1 proto-oncogene	Homo sapiens	111-115
12161073-4	2002	Two other residues, Lys 114 and Arg 129, then cooperate with Lys 125 to induce the low-affinity complex into an activated, high-affinity complex, in which a network of electrostatic interactions between antithrombin and the entire pentasaccharide is established.	Lysine	20-23	serpin family C member 1	Homo sapiens	203-215
12161073-4	2002	Two other residues, Lys 114 and Arg 129, then cooperate with Lys 125 to induce the low-affinity complex into an activated, high-affinity complex, in which a network of electrostatic interactions between antithrombin and the entire pentasaccharide is established.	Lysine	61-64	serpin family C member 1	Homo sapiens	203-215
34008351-14	2021	Capsid protein of three PCV2b and five PCV2b IM1 isolates had extra amino acid residue lysine (K) at 234 position of ORF2 similar to PCV2d.	Lysine	87-93	capsid protein	Porcine circovirus 2	117-121
33998601-8	2021	PTIP, an essential component of the activating histone H3 lysine 4 trimethylation (H3K4Me3) complex, interacts with DACH1 and is recruited by DACH1 to its promoter-binding sites.	Lysine	58-64	dachshund family transcription factor 1	Mus musculus	116-121
33998601-8	2021	PTIP, an essential component of the activating histone H3 lysine 4 trimethylation (H3K4Me3) complex, interacts with DACH1 and is recruited by DACH1 to its promoter-binding sites.	Lysine	58-64	dachshund family transcription factor 1	Mus musculus	142-147
11919189-8	2002	This peripheral staining of ICAP-1alpha and nm23-H2 is only observed in cells spreading on fibronectin and collagen and is absent in cells spreading on poly-l-lysine, vitronectin, or laminin.	Lysine	152-165	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	44-51
28329675-0	2017	Trimethylation and Acetylation of beta-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency.	Lysine	50-56	catenin beta 1	Homo sapiens	34-46
12443043-0	2002	Synthesis of potential anti-HIV GP120 inhibitors using a lysine template.	Lysine	57-63	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	32-37
34010627-2	2021	We demonstrate that loss of the lysine 9 of histone H3 (H3K9) methyltransferase G9a in the mammary epithelium results in de novo chromatin opening, aberrant formation of the mammary ductal tree, impaired stem cell potential, disrupted intraductal polarity, and loss of tissue function.	Lysine	32-38	euchromatic histone lysine methyltransferase 2	Homo sapiens	80-83
28329675-2	2017	Here, we show that lysine 49 (K49) of beta-catenin is trimethylated (beta-catMe3) by Ezh2 or acetylated (beta-catAc) by Cbp.	Lysine	19-25	catenin beta 1	Homo sapiens	38-50
28110910-9	2017	Importantly, using lysine-mutated forms of TCTP, we show that acetylation of Lysine 19 generates a KFERQ-like motif and promotes binding to Hsc70, lysosome targeting and TCTP degradation by CMA.	Lysine	19-25	tumor protein, translationally-controlled 1	Homo sapiens	43-47
34055852-9	2021	In addition, the expression levels of sirtuin 1 (SIRT1) were also increased while acetylated lysine levels were decreased, indicating that SIRT1 activity was stimulated by stigmasterol, and the result was comparable with the known SIRT1 activator, resveratrol.	Lysine	93-99	sirtuin 1	Homo sapiens	139-144
34055852-9	2021	In addition, the expression levels of sirtuin 1 (SIRT1) were also increased while acetylated lysine levels were decreased, indicating that SIRT1 activity was stimulated by stigmasterol, and the result was comparable with the known SIRT1 activator, resveratrol.	Lysine	93-99	sirtuin 1	Homo sapiens	139-144
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Lysine	170-176	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	72-76
12134953-9	2002	The uptake of Arg-Lys*, beta-Ala-Lys*, and Gly-Sar-Lys* was blocked (approximately 50%) by cephradine (an inhibitor of PepT1 for peptide transport) but not by Lys (an inhibitor on cationic amino acid transporter 2B for Arg transport).	Lysine	18-21	solute carrier family 15 member 1	Rattus norvegicus	119-124
12022882-6	2002	The reactivities of Arg(143) and Lys(147) mutants were improved approximately 2-fold with antithrombin in the absence but not in the presence of heparin cofactors.	Lysine	33-36	serpin family C member 1	Homo sapiens	90-102
28110910-9	2017	Importantly, using lysine-mutated forms of TCTP, we show that acetylation of Lysine 19 generates a KFERQ-like motif and promotes binding to Hsc70, lysosome targeting and TCTP degradation by CMA.	Lysine	77-83	tumor protein, translationally-controlled 1	Homo sapiens	43-47
11861643-3	2002	We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity.	Lysine	209-212	monoamine oxidase A	Homo sapiens	61-72
33723435-4	2021	Dimethylation of lysine 79 of histone H3 (H3K79me2) and the enzymes (DOT1L and KDM2B) that control this modification are enriched in D2-type medium spiny neurons and are shown to be crucial for the expression of ELS-induced stress susceptibility.	Lysine	17-23	H3 clustered histone 7	Mus musculus	30-40
28110910-9	2017	Importantly, using lysine-mutated forms of TCTP, we show that acetylation of Lysine 19 generates a KFERQ-like motif and promotes binding to Hsc70, lysosome targeting and TCTP degradation by CMA.	Lysine	77-83	tumor protein, translationally-controlled 1	Homo sapiens	170-174
11861643-3	2002	We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity.	Lysine	209-212	monoamine oxidase A	Homo sapiens	61-66
11861643-4	2002	Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.	Lysine	89-92	monoamine oxidase A	Homo sapiens	122-127
33905682-4	2021	The Chelator-GIDSR4 assembly avidly binds multiple Fbp1 degrons so that multiple Fbp1 protomers are simultaneously ubiquitylated at lysines near the allosteric and substrate binding sites.	Lysine	132-139	fructose-bisphosphatase 1	Homo sapiens	51-55
33905682-4	2021	The Chelator-GIDSR4 assembly avidly binds multiple Fbp1 degrons so that multiple Fbp1 protomers are simultaneously ubiquitylated at lysines near the allosteric and substrate binding sites.	Lysine	132-139	fructose-bisphosphatase 1	Homo sapiens	81-85
28069602-3	2017	Here, we identified the lysine-specific demethylase KDM1A as a novel interaction partner of ZEB2 and demonstrated that mouse and human T-ALLs with increased ZEB2 levels critically depend on KDM1A activity for survival.	Lysine	24-30	zinc finger E-box binding homeobox 2	Mus musculus	92-96
33907746-3	2021	Here we reported that SUPT16H, a subunit of FACT, is acetylated at lysine 674 (K674) of middle domain (MD), which involves TIP60 histone acetyltransferase.	Lysine	67-73	lysine acetyltransferase 5	Homo sapiens	123-128
28069602-3	2017	Here, we identified the lysine-specific demethylase KDM1A as a novel interaction partner of ZEB2 and demonstrated that mouse and human T-ALLs with increased ZEB2 levels critically depend on KDM1A activity for survival.	Lysine	24-30	zinc finger E-box binding homeobox 2	Homo sapiens	157-161
28222195-10	2017	De novo sequencing showed that there was a mutation at either of the SS positions on the CDR1 region, which changed one of the serine residues to a basic amino acid, i.e., arginine or lysine.	Lysine	184-190	cerebellar degeneration related protein 1	Homo sapiens	89-93
33872660-6	2021	HDAC inhibitors are potent drug molecules that can induce acetylation of histones at lysine residues and induce open chromatin conformation at tumor suppressor gene loci and thus resulting in tumor suppression.	Lysine	85-91	histone deacetylase 9	Homo sapiens	0-4
11801591-2	2002	We characterize a proteolytic variant of beta(2)-microglobulin (cleaved after Lys(58)) that as a trimmed form (Lys(58) is removed) can be demonstrated in the circulation in patients with chronic disease.	Lysine	78-81	beta-2-microglobulin	Homo sapiens	41-62
11801591-2	2002	We characterize a proteolytic variant of beta(2)-microglobulin (cleaved after Lys(58)) that as a trimmed form (Lys(58) is removed) can be demonstrated in the circulation in patients with chronic disease.	Lysine	111-114	beta-2-microglobulin	Homo sapiens	41-62
11801591-6	2002	Together with analysis of the differences in circular dichroism, the results suggest that beta(2)-microglobulin cleaved after Lys(58) readily adopts two equilibrium conformations under native conditions.	Lysine	126-129	beta-2-microglobulin	Homo sapiens	90-111
33851515-6	2021	The c.298delA variant would cause translation of a 34-residue C-terminus distal to lysine residue 99 in the predicted transmembrane domain II of the full-length sequence p.(Thr100LeufsTer35) and would affect the translation products of all protein-coding SDHD isoforms containing transmembrane topologies required for positional integration in the inner mitochondrial membrane and complex formation.	Lysine	83-89	succinate dehydrogenase complex subunit D	Homo sapiens	255-259
28137876-0	2017	Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.	Lysine	19-25	sirtuin 1	Mus musculus	0-8
11884629-2	2002	Chemical modification of murine CAD with the lysine-specific reagent 2,4,6-trinitrobenzenesulphonic acid and the tyrosine-specific reagent N-acetylimidazole leads to inactivation of the nuclease, indicating that lysine and tyrosine residues are important for DNA cleavage by this enzyme.	Lysine	45-51	DNA fragmentation factor, beta subunit	Mus musculus	32-35
28137876-5	2017	Using diabetes as an oxidative stimulus, we demonstrate that p66Shc is acetylated under high glucose conditions and is deacetylated by Sirt1 on lysine 81.	Lysine	144-150	sirtuin 1	Mus musculus	135-140
11884629-2	2002	Chemical modification of murine CAD with the lysine-specific reagent 2,4,6-trinitrobenzenesulphonic acid and the tyrosine-specific reagent N-acetylimidazole leads to inactivation of the nuclease, indicating that lysine and tyrosine residues are important for DNA cleavage by this enzyme.	Lysine	212-218	DNA fragmentation factor, beta subunit	Mus musculus	32-35
11884629-4	2002	Amino acid substitution in murine CAD of lysines and tyrosines conserved in CADs from five different species leads to variants with little if any catalytic activity, but unaltered DNA binding (K155Q, K301Q, K310Q, Y247F), with the exception of Y170F, which retains wild-type activity.	Lysine	41-48	DNA fragmentation factor, beta subunit	Mus musculus	34-37
28115710-5	2017	A short sequence of amino acids at the C terminus of ZFP809, including a single lysine residue (K391), is required for the rapid turnover of the protein.	Lysine	80-86	zinc finger protein 809	Mus musculus	53-59
33916919-0	2021	Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA.	Lysine	151-157	reactive intermediate imine deaminase A homolog	Homo sapiens	50-97
33916919-0	2021	Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA.	Lysine	151-157	reactive intermediate imine deaminase A homolog	Homo sapiens	99-103
33916919-0	2021	Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA.	Lysine	151-157	reactive intermediate imine deaminase A homolog	Homo sapiens	175-179
33916919-7	2021	Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation.	Lysine	102-108	reactive intermediate imine deaminase A homolog	Homo sapiens	28-32
11876649-11	2002	Treatment with the proteasome inhibitor clasto-lactacystin beta-lactone increased the cytotoxicity of the lysine-rich RTA to a level approaching that of wild-type ricin.	Lysine	106-112	MAS related GPR family member F	Homo sapiens	118-121
27992417-1	2017	Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture.	Lysine	8-14	lysine methyltransferase 2A	Homo sapiens	64-67
11741963-4	2002	To investigate the role of helix D elongation in the allosteric activation of antithrombin, we substituted a proline residue for Lys(133).	Lysine	129-132	serpin family C member 1	Homo sapiens	78-90
11850410-3	2002	Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation.	Lysine	29-35	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-4
33279621-4	2021	Here, we showed that the shedding of the mouse NKG2D ligand Rae-1 can be prevented by two critical acetyltransferases, GCN5 and PCAF, which acetylate the lysine residues of Rae-1 to avoid shedding both in vitro and in vivo.	Lysine	154-160	K(lysine) acetyltransferase 2A	Mus musculus	119-123
33279621-4	2021	Here, we showed that the shedding of the mouse NKG2D ligand Rae-1 can be prevented by two critical acetyltransferases, GCN5 and PCAF, which acetylate the lysine residues of Rae-1 to avoid shedding both in vitro and in vivo.	Lysine	154-160	ribonucleic acid export 1	Mus musculus	173-178
33279621-5	2021	In contrast, mutations at lysines 80 and 87 of Rae-1 abrogated this acetylation and thereby desensitized tumor cells to NKG2D-dependent immune surveillance.	Lysine	26-33	ribonucleic acid export 1	Mus musculus	47-52
33279621-7	2021	Our results suggest that the acetylation of Rae-1 protein at lysines 80 and 87 by GCN5 and PCAF protects Rae-1 from shedding so as to activate NKG2D-dependent immune surveillance.	Lysine	61-68	ribonucleic acid export 1	Homo sapiens	44-49
33279621-7	2021	Our results suggest that the acetylation of Rae-1 protein at lysines 80 and 87 by GCN5 and PCAF protects Rae-1 from shedding so as to activate NKG2D-dependent immune surveillance.	Lysine	61-68	lysine acetyltransferase 2A	Homo sapiens	82-86
33279621-7	2021	Our results suggest that the acetylation of Rae-1 protein at lysines 80 and 87 by GCN5 and PCAF protects Rae-1 from shedding so as to activate NKG2D-dependent immune surveillance.	Lysine	61-68	ribonucleic acid export 1	Homo sapiens	105-110
27965357-0	2017	Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells.	Lysine	33-36	inhibin subunit beta E	Homo sapiens	0-7
33834259-6	2021	We identify lysine residue 952, located at the activation loop of p110beta, as essential for SUMOylation.	Lysine	12-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	66-74
27965357-3	2017	In this study, we report that levels of histone H3 Lys-27 trimethylation (H3K27me3) decrease during ME initiation, which is essential for subsequent differentiation induced by the combined effects of activin and Wnt signaling.	Lysine	51-54	inhibin subunit beta E	Homo sapiens	200-207
28011426-2	2017	Histone deacetylases (HDACs) can deacetylate the lysine residues of RUNX3, followed by degradation via a ubiquitin-mediated pathway.	Lysine	49-55	RUNX family transcription factor 3	Homo sapiens	68-73
33869198-4	2021	Here, by using multiple reaction monitoring (MRM) based LC-MS/MS, we detected dynamic changes of histone H3 lysine post-translational modifications (PTMs).	Lysine	108-114	histone H3	Saccharomyces cerevisiae S288C	97-107
33153715-2	2021	Amino-rich polypeptide, poly-l-lysine (PLL), is applied to modify the ultra-thin Ti3C2 MXene nanosheets with a compatible surface for GOx immobilization.	Lysine	24-37	hydroxyacid oxidase 1	Homo sapiens	134-137
11812233-6	2002	His-tagged Pth was shown to be biologically active by its ability to hydrolyze diacetyl-[(3)H]Lys-tRNA(Lys) in a time- and concentration-dependent manner.	Lysine	94-97	AT695_RS00135	Staphylococcus aureus	11-14
11812233-8	2002	The K(m) of the diacetyl-[(3)H]-Lys-tRNA(Lys) substrate for S. aureus Pth was determined to be 2.8 microM.	Lysine	32-35	AT695_RS00135	Staphylococcus aureus	70-73
11812233-8	2002	The K(m) of the diacetyl-[(3)H]-Lys-tRNA(Lys) substrate for S. aureus Pth was determined to be 2.8 microM.	Lysine	41-44	AT695_RS00135	Staphylococcus aureus	70-73
27865840-5	2017	The N-terminal fragment of SSH1 bound to and co-localized with F-actin, but mutation at Arg-96 or a Leu-His-Lys (LHK) motif in the PH-like domain reduced this activity.	Lysine	108-111	slingshot protein phosphatase 1	Homo sapiens	27-31
11786529-9	2002	These results indicate that a positively charged arginine or lysine residue at position 1232 in the double mutant is required for the proper transport and functional expression of the hNa(v)1.5 protein.	Lysine	61-67	immunoglobulin lambda variable 2-18	Homo sapiens	184-193
33720451-5	2021	Meanwhile, SNP_12 (Chr22-g. 11721225 A>T) and SNP_13 (Chr22-g. 11721227 A>C) (NC_030829.1) simultaneously mutated at the first and third position of a triplet AAA (lysine, K) in the exon 4 of ACVR2B gene (XM_018066623.1) had estimated genetic effects of HOM1 (0.00) and HOM2 (0.03) lager than HET (-0.12).	Lysine	164-170	activin receptor type-2B	Capra hircus	192-198
27939291-5	2017	Contrary to a previous proposal that Ulp1p is tethered to the transport channel of the NPC through unconventional interactions with the karyopherins, our structures reveal that Ulp1p has canonical nuclear localization signals (NLSs): (1) an isoleucine-lysine-NLS (residues 51-55) that binds to the NLS-binding site of Kap121p, and (2) a classical bipartite NLS (residues 154-172) that binds to the major and minor NLS-binding sites of Kap60p.	Lysine	252-258	SUMO protease ULP1	Saccharomyces cerevisiae S288C	177-182
33750776-4	2021	Following single-cell analysis and multivariate modeling, we identify three classes of epigenetic inhibitors that target distinct epigenetic states associated with either one of the lysine-specific histone demethylases Kdm1a or Kdm4b, or BET bromodomain proteins.	Lysine	182-188	lysine demethylase 1A	Homo sapiens	219-224
11756545-5	2002	In this report, we show that Smt3 conjugation occurs at a single site in Dorsal (lysine 382), requires just the Smt3-activating and -conjugating enzymes, and is reversed by the deconjugating enzyme Ulp1.	Lysine	81-87	Ulp1	Drosophila melanogaster	198-202
28429670-1	2017	PURPOSE: Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacification (PCO) in a rabbit PCO model.	Lysine	181-187	ubiquitin	Oryctolagus cuniculus	159-168
11742990-0	2001	The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.	Lysine	94-100	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	29-33
11742990-7	2001	Since methylation of H3 lysine 4 is widespread in eukaryotes, we screened the databases and found other Set1 homologues.	Lysine	24-30	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	104-108
33676897-9	2021	Additionally, beta-TrCP1 impedes MDM2 accumulation via abrogation of its lysine 63-linked polyubiquitination by beta-TrCP2.	Lysine	73-79	MDM2 proto-oncogene	Homo sapiens	33-37
28539967-5	2017	Phosphorylation of Akt and ERK5 (upstream of NFkappaB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively.	Lysine	142-144	mitogen-activated protein kinase 7	Homo sapiens	27-31
33522413-9	2021	ChIP using mouse or human kidney determined that PAX2 is highly enriched in the AVPR2 promoter alongside PTIP and HMT proteins, leading to high levels of histone H3 lysine trimethylation within the promoter and throughout the gene.	Lysine	165-171	paired box 2	Homo sapiens	49-53
11747809-3	2001	Here we report that methylation of histone H3 lysine 9 on the inactive X chromosome occurs immediately after Xist RNA coating and before transcriptional inactivation of X-linked genes.	Lysine	46-52	X inactive specific transcript	Homo sapiens	109-113
11747809-6	2001	We also identify a unique "hotspot" of H3 Lys-9 methylation 5" to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation.	Lysine	42-45	X inactive specific transcript	Homo sapiens	66-70
11779497-1	2001	Methylation of histone H3 at lysine 9 by SUV39H1 and subsequent recruitment of the heterochromatin protein HP1 has recently been linked to gene silencing.	Lysine	29-35	defensin alpha 1	Homo sapiens	107-110
28539967-5	2017	Phosphorylation of Akt and ERK5 (upstream of NFkappaB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively.	Lysine	142-144	mitogen-activated protein kinase 7	Homo sapiens	193-197
29313432-0	2017	Hb Hornchurch [beta43(CD2)Glu Lys; HBB: c.130G&gt;A] Compromises the Molecular Diagnosis of beta-Thalassemia in a Chinese Family.	Lysine	30-33	CD2 molecule	Homo sapiens	22-25
11489881-4	2001	Importantly, the activation of PYK2 caused by inhibition of Rho or ROCK takes place only when the T-cells are plated onto ICAM-1 but not when they are either prevented from interacting with ICAM-1 with anti-LFA-1 blocking antibodies or when they are plated on the nonspecific poly-l-lysine substrate.	Lysine	276-289	protein tyrosine kinase 2 beta	Homo sapiens	31-35
33550070-1	2021	Lysine-specific histone demethylase 1 (LSD1) was the first histone demethylase identified in epigenetics and has recently emerged as an attractive therapeutic target for treating tumors.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	39-43
33540026-4	2021	Here, we investigated the species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1)-utilizing L-lysine analogue of ketoprofen (KPF) (compound 1) and KPF itself by the whole tissue and brain microdialysis methods in mice, and compared the results to those previously reported in rats.	Lysine	133-141	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	84-115
33540026-4	2021	Here, we investigated the species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1)-utilizing L-lysine analogue of ketoprofen (KPF) (compound 1) and KPF itself by the whole tissue and brain microdialysis methods in mice, and compared the results to those previously reported in rats.	Lysine	133-141	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	117-121
27038808-1	2017	MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome.	Lysine	119-125	males absent on the first	Drosophila melanogaster	0-3
33580754-5	2021	The high expression of Lhx8 in the early dental mesenchyme maintained the cell fate in an undifferentiated status by interacting with Suv39h1, a histone-lysine N-methyltransferase constitutively expressed in the dental mesenchyme.	Lysine	153-159	LIM homeobox 8	Homo sapiens	23-27
11504715-3	2001	The Mms2-Ubc13 heterodimer is capable of linking ubiquitin molecules to one another through an isopeptide bond between the C terminus and Lys-63.	Lysine	138-141	ubiquitin conjugating enzyme E2 V2	Homo sapiens	4-8
27975250-0	2017	Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer"s Disease Brain.	Lysine	30-36	microtubule associated protein tau	Homo sapiens	72-75
11504715-3	2001	The Mms2-Ubc13 heterodimer is capable of linking ubiquitin molecules to one another through an isopeptide bond between the C terminus and Lys-63.	Lysine	138-141	ubiquitin conjugating enzyme E2 N	Homo sapiens	9-14
11504715-10	2001	These results suggest that the role of Mms2 is to correctly orient either a target-bound or untethered ubiquitin molecule such that its Lys-63 is placed proximally to the C terminus of the ubiquitin molecule that is linked to the active site of Ubc13.	Lysine	136-139	ubiquitin conjugating enzyme E2 V2	Homo sapiens	39-43
33379119-6	2021	The peptide with one lysine acetyl group acts as both the Cy5 fluorophore carrier and the substrate for sensing SIRT1.	Lysine	21-27	sirtuin 1	Homo sapiens	112-117
33571308-3	2021	Here, we found that a conserved lysine residue at position 612 (K612) of the polymerase basic protein 1 (PB1) of IAV is a bona fide SUMOylation site.	Lysine	32-38	polybromo 1	Homo sapiens	105-108
27975250-5	2017	Lysine-directed PTMs including ubiquitylation, acetylation, and methylation play key regulatory roles with respect to the rates of tau turnover and aggregation.	Lysine	0-6	microtubule associated protein tau	Homo sapiens	131-134
11606055-5	2001	The predicted amino acid sequence of H2RSP contained two unique domains, namely the serine-rich region (exon 3) and the lysine-rich region (exon 4).	Lysine	120-126	chromosome 19 open reading frame 33	Homo sapiens	37-42
27975250-6	2017	MS-based analytical approaches have been used to gain insight into the tau lysine-directed PTM signature that is most closely associated with neurofibrillary lesion formation.	Lysine	75-81	microtubule associated protein tau	Homo sapiens	71-74
11606055-6	2001	Transfection of deleted series of H2RSP cDNAs fused to enhanced green fluorescent protein (EGFP) into HeLa cells revealed that H2RSP has nuclear localization signal in the lysine-rich region.	Lysine	172-178	chromosome 19 open reading frame 33	Homo sapiens	34-39
27975250-7	2017	This chapter provides details pertaining to the liquid chromatography tandem mass spectrometry (LC-MS/MS)-based analysis of the lysine-directed posttranslational modification of tau.	Lysine	128-134	microtubule associated protein tau	Homo sapiens	178-181
11606055-6	2001	Transfection of deleted series of H2RSP cDNAs fused to enhanced green fluorescent protein (EGFP) into HeLa cells revealed that H2RSP has nuclear localization signal in the lysine-rich region.	Lysine	172-178	chromosome 19 open reading frame 33	Homo sapiens	127-132
33526670-1	2021	KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain.	Lysine	105-111	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27522651-6	2016	We identified leucine, lysine, and tryptophan analogs bearing the Fmoc group as selective inhibitors of BChE.	Lysine	23-29	butyrylcholinesterase	Homo sapiens	104-108
33369872-7	2021	Ubiquitin remnant profiling identified receptor-interacting protein kinase 3 (RIPK3) lysines 42, 351, and 518 as novel, USP22-regulated ubiquitination sites during necroptosis.	Lysine	85-92	receptor interacting serine/threonine kinase 3	Homo sapiens	39-76
11599707-3	2001	Within each age period, diets contained NRC recommended levels of Lys with other EAA at 100, 110, 120, or 130% of NRC.	Lysine	66-69	nuclear receptor coactivator 6	Homo sapiens	40-43
11599707-8	2001	The BW was significantly increased at 21 and 42 d by addition of + 0.1% Lys above NRC but not at 56 d. There was no significant effect of other EAA on BW at any age.	Lysine	72-75	nuclear receptor coactivator 6	Homo sapiens	82-85
33369872-7	2021	Ubiquitin remnant profiling identified receptor-interacting protein kinase 3 (RIPK3) lysines 42, 351, and 518 as novel, USP22-regulated ubiquitination sites during necroptosis.	Lysine	85-92	receptor interacting serine/threonine kinase 3	Homo sapiens	78-83
27737800-5	2016	The repressive histone mark histone 3 lysine 27 trimethylation (H3K27me3), known to prevent chromatin remodelling and transcription, was removed from the SPINT2 but not the CCL18 gene locus under hypoxia or dimethyloxalylglycine-treatment.	Lysine	38-44	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	154-160
33420361-6	2021	Furthermore, we found that CREB could recruit MMSET, leading to the stabilization of HIF-1alpha protein and the increased dimethylation of histone H3 at lysine 36 on the DKK1 promoter.	Lysine	153-159	cAMP responsive element binding protein 1	Homo sapiens	27-31
33469837-2	2021	Previously, we found that the acetylation levels of chloride intracellular channel 1 (CLIC1) at lysine 131 were increased in cervical cancer tissues using a label-free proteomics approach.	Lysine	96-102	chloride intracellular channel 1	Homo sapiens	52-84
33469837-2	2021	Previously, we found that the acetylation levels of chloride intracellular channel 1 (CLIC1) at lysine 131 were increased in cervical cancer tissues using a label-free proteomics approach.	Lysine	96-102	chloride intracellular channel 1	Homo sapiens	86-91
11599707-10	2001	At 21 and 42 d, addition of 0.1% Lys to diets containing the NRC Lys level significantly improved feed conversion; response to 0.2 or 0.3% Lys were varied.	Lysine	33-36	nuclear receptor coactivator 6	Homo sapiens	61-64
11599707-10	2001	At 21 and 42 d, addition of 0.1% Lys to diets containing the NRC Lys level significantly improved feed conversion; response to 0.2 or 0.3% Lys were varied.	Lysine	65-68	nuclear receptor coactivator 6	Homo sapiens	61-64
11599707-10	2001	At 21 and 42 d, addition of 0.1% Lys to diets containing the NRC Lys level significantly improved feed conversion; response to 0.2 or 0.3% Lys were varied.	Lysine	65-68	nuclear receptor coactivator 6	Homo sapiens	61-64
11599707-14	2001	These results indicate that NRC (1994) levels of Lys and other EAA are adequate for optimum performance of male broilers processed at 56 d but may be less than adequate at younger ages.	Lysine	49-52	nuclear receptor coactivator 6	Homo sapiens	28-31
11477073-2	2001	A region of 9 conserved amino acid residues (residues Gln-337 through Lys-345) in the C terminus of human FEN-1 (hFEN-1) was shown to be responsible for the interaction with PCNA.	Lysine	70-73	flap structure-specific endonuclease 1	Homo sapiens	113-119
11477073-2	2001	A region of 9 conserved amino acid residues (residues Gln-337 through Lys-345) in the C terminus of human FEN-1 (hFEN-1) was shown to be responsible for the interaction with PCNA.	Lysine	70-73	proliferating cell nuclear antigen	Homo sapiens	174-178
33472068-6	2021	Collectively, these results suggest that HDAC inhibition functions, at least in part, through expansion of a rare histone acetylation state, which then retargets lysine-acetyl readers associated with changes in gene expression, partially mimicking the effect of bromodomain inhibition.	Lysine	162-168	histone deacetylase 9	Homo sapiens	41-45
33472079-7	2021	The cytosolic ERAL1 facilitates lysine 63 (K63)-linked ubiquitination of retinoicacid inducible gene-1 (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) and promotes downstream MAVS polymerization, thus positively regulating antiviral responses.	Lysine	32-38	DEAD/H box helicase 58	Mus musculus	104-109
33472079-7	2021	The cytosolic ERAL1 facilitates lysine 63 (K63)-linked ubiquitination of retinoicacid inducible gene-1 (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) and promotes downstream MAVS polymerization, thus positively regulating antiviral responses.	Lysine	32-38	interferon induced with helicase C domain 1	Mus musculus	155-159
33472079-7	2021	The cytosolic ERAL1 facilitates lysine 63 (K63)-linked ubiquitination of retinoicacid inducible gene-1 (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) and promotes downstream MAVS polymerization, thus positively regulating antiviral responses.	Lysine	32-38	mitochondrial antiviral signaling protein	Mus musculus	185-189
33472082-5	2021	Through modification of SQSTM1/p62 on lysine 435, the ER-embedded UBE2J1/RNF26 ubiquitylation complex recruits endosomal adaptors to immobilize their cognate vesicles in the perinuclear region of the cell.	Lysine	38-44	sequestosome 1	Homo sapiens	24-30
33472082-5	2021	Through modification of SQSTM1/p62 on lysine 435, the ER-embedded UBE2J1/RNF26 ubiquitylation complex recruits endosomal adaptors to immobilize their cognate vesicles in the perinuclear region of the cell.	Lysine	38-44	sequestosome 1	Homo sapiens	31-34
27775714-3	2016	Here we demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylations with the strongest preference for Kcr.	Lysine	192-198	lysine acetyltransferase 6A	Homo sapiens	98-101
33472082-5	2021	Through modification of SQSTM1/p62 on lysine 435, the ER-embedded UBE2J1/RNF26 ubiquitylation complex recruits endosomal adaptors to immobilize their cognate vesicles in the perinuclear region of the cell.	Lysine	38-44	ring finger protein 26	Homo sapiens	73-78
33614242-8	2021	Furthermore, the expression of miR-1224 was inhibited by CREB through EZH2-mediated histone 3 lysine 27 (H3K27me3) on miR-1224 promoter, thus forming a positive feedback circuit.	Lysine	94-100	cAMP responsive element binding protein 1	Homo sapiens	57-61
33523893-4	2021	Here, we found that TBC1D3 interacts with G9a, a euchromatic histone lysine N-methyltransferase, which mediates dimethylation of histone 3 in lysine 9 (H3K9me2), a suppressive mark for gene expression.	Lysine	69-75	euchromatic histone lysine methyltransferase 2	Homo sapiens	42-45
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Lysine	105-111	replication factor C subunit 4	Saccharomyces cerevisiae S288C	158-162
27775714-3	2016	Here we demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylations with the strongest preference for Kcr.	Lysine	192-198	lysine acetyltransferase 6A	Homo sapiens	117-122
11583162-1	2001	Acetylation of Lys residues of horse cytochrome c steadily stabilizes the molten globule state in 18 mM HCl as more Lys residues are acetylated [Goto and Nishikiori (1991) J. Mol.	Lysine	15-18	cytochrome c, somatic	Equus caballus	37-49
27775714-3	2016	Here we demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylations with the strongest preference for Kcr.	Lysine	192-198	double PHD fingers 2	Homo sapiens	128-132
11583162-1	2001	Acetylation of Lys residues of horse cytochrome c steadily stabilizes the molten globule state in 18 mM HCl as more Lys residues are acetylated [Goto and Nishikiori (1991) J. Mol.	Lysine	116-119	cytochrome c, somatic	Equus caballus	37-49
11583162-6	2001	One to four Lys residue-acetylated cytochrome c showed almost no protection of the amide protons from rapid exchange.	Lysine	12-15	cytochrome c, somatic	Equus caballus	35-47
27775714-3	2016	Here we demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylations with the strongest preference for Kcr.	Lysine	192-198	double PHD fingers 2	Homo sapiens	148-154
11463825-4	2001	For H4, underacetylation of the maternal allele was exclusively (U2af1-rs1) or predominantly (Snrpn) at lysine 5.	Lysine	104-110	small nuclear ribonucleoprotein N	Mus musculus	94-99
33441904-8	2021	Furthermore, the interaction between 4b and the ADAMTS-5 Dis domain is mediated by hydrogen bonds between the sugar moiety and two lysine residues (K532 and K533).	Lysine	131-137	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	48-56
27485686-1	2016	Lysine (K) methyltransferase 2a (Kmt2a) and other regulators of H3 lysine 4 methylation, a histone modification enriched at promoters and enhancers, are widely expressed throughout the brain, but molecular and cellular phenotypes in subcortical areas remain poorly explored.	Lysine	67-73	lysine methyltransferase 2A	Homo sapiens	33-38
33450416-1	2021	INTRODUCTION: Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders.	Lysine	42-48	lysine demethylase 6B	Homo sapiens	64-94
33450416-1	2021	INTRODUCTION: Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders.	Lysine	42-48	lysine demethylase 6B	Homo sapiens	96-101
11473255-6	2001	The structure of the hMms2-hUbc13 complex provides the conceptual foundation for understanding the mechanism of Lys 63 multiubiquitin chain assembly and for its interactions with the RING finger proteins Rad5 and Traf6.	Lysine	112-115	ubiquitin conjugating enzyme E2 V2	Homo sapiens	21-26
11473255-6	2001	The structure of the hMms2-hUbc13 complex provides the conceptual foundation for understanding the mechanism of Lys 63 multiubiquitin chain assembly and for its interactions with the RING finger proteins Rad5 and Traf6.	Lysine	112-115	ubiquitin conjugating enzyme E2 N	Homo sapiens	27-33
11313341-5	2001	Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin.	Lysine	44-47	acrosin	Homo sapiens	9-16
33411826-14	2021	Histone 3 acetylation at lysine 18 was significantly increased when excess folic acid was applied to cells with the MTHFR knockdown, as was histone 3 phosphorylation at serine 10.	Lysine	25-31	methylenetetrahydrofolate reductase	Homo sapiens	116-121
28105224-5	2016	In addition, the histone modification status of the PDCD4 gene was analyzed, and chromatin immunoprecipitation assay identified a high density of histone 3 lysine 27 trimethylation on the promoter of PDCD4, which was associated with the long non-coding RNA, homeobox transcript antisense RNA (HOTAIR).	Lysine	156-162	HOX transcript antisense RNA	Homo sapiens	293-299
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	protein tyrosine phosphatase receptor type C	Homo sapiens	118-122
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	SRY-box transcription factor 2	Homo sapiens	194-198
33407870-5	2021	RESULTS: We found the combination of LLY-507 and AZD5153 was sufficient for high-efficiency CD73+CD90+CD105+CD31-CD34-CD45-HLA-DR- MSC induction from both hESCs and hiPSCs with stemness (POU5F1/SOX2/NANOG).	Lysine	37-40	Nanog homeobox	Homo sapiens	199-204
11313341-5	2001	Ascidian acrosin has paired basic residues (Lys(56)-His(57)) in the N-terminal region, which is one of the most characteristic features of mammalian acrosin.	Lysine	44-47	acrosin	Homo sapiens	149-156
27349498-0	2016	Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells.	Lysine	11-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-96
11530934-5	2001	This indicates that these two lysine residues are sufficient for conferring ER-residency on OST48.	Lysine	30-36	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	92-97
11530934-10	2001	Consequently, the double-lysine motif in the cytosolic domain of OST48 is unlikely to have a primary function except being involved in re-capture of molecules which have escaped from the ER.	Lysine	25-31	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	65-70
33170804-7	2021	Using quantitative proteomics, we identified the ubiquitinated lysine residues on mutant AR that are regulated by USP7.	Lysine	63-69	androgen receptor	Mus musculus	89-91
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	228-234	cationic amino acid transporter	Saccharomyces cerevisiae S288C	203-207
33351098-5	2021	Cell Biol.https://doi.org/10.1083/jcb.202001116) show that in Saccharomyces cerevisiae, the vacuole-associated Rsp5 ubiquitin ligase uses a TMD in substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation.	Lysine	280-286	cationic amino acid transporter	Saccharomyces cerevisiae S288C	203-207
33351099-3	2021	Here, we describe how Ssh4, a yeast E3 ligase adaptor, recognizes the PQ-loop lysine transporter Ypq1 only after lysine starvation.	Lysine	78-84	cationic amino acid transporter	Saccharomyces cerevisiae S288C	97-101
27783990-3	2016	USP9X binds beta-catenin and removes the Lys 48-linked polyubiquitin chains that normally mark beta-catenin for proteasomal degradation.	Lysine	41-44	catenin beta 1	Homo sapiens	95-107
33351099-3	2021	Here, we describe how Ssh4, a yeast E3 ligase adaptor, recognizes the PQ-loop lysine transporter Ypq1 only after lysine starvation.	Lysine	113-119	cationic amino acid transporter	Saccharomyces cerevisiae S288C	97-101
33361537-5	2021	H2O2-treated cells showed high levels of H3K9me2 (histone H3 demethylated at the lysine 9 residue), which is produced by G9a activation; BIX01294 treatment reduced aberrant activation of G9a.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	121-124
11323431-6	2001	It is concluded that Ctx residues Lys-10 and the N terminal interact with oppositely charged receptor residues only at the alphadelta site, and the two sites have distinct arrangements of charged residues.	Lysine	34-37	V-set and immunoglobulin domain containing 2	Mus musculus	21-24
11430834-2	2001	To understand the function of H2A.Z acetylation, we performed a mutagenic analysis of the six acetylated lysines in the N-terminal tail of Tetrahymena H2A.Z.	Lysine	105-112	H2A.Z variant histone 1	Homo sapiens	151-156
11430834-4	2001	Retention of one acetylatable lysine is sufficient to provide the essential function of H2A.Z acetylation.	Lysine	30-36	H2A.Z variant histone 1	Homo sapiens	88-93
27834370-4	2016	AUX1 expression and histone H3 acetylation at lysines 9 and 18 is regulated by SNL1 and SNL2.	Lysine	46-53	SIN3-like 1	Arabidopsis thaliana	79-83
11378154-3	2001	We observed that both AIDA (100 microM) and LY 367385 (30 microM), two blockers of mGluR1s, were able to fully prevent the induction of this form of synaptic plasticity, whereas MPEP (30 microM), a selective antagonist of the mGluR5 subtype, did not significantly affect the amplitude and time-course of corticostriatal LTD.	Lysine	44-46	glutamate receptor, metabotropic 1	Mus musculus	83-89
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	51-54	serpin family E member 1	Homo sapiens	27-32
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	59-62	serpin family E member 1	Homo sapiens	27-32
33299181-5	2021	This decompaction drives distinct changes in epigenetic states, primarily owing to a gain of histone H3 dimethylation at lysine 36 (H3K36me2) and/or loss of repressive H3 trimethylation at lysine 27 (H3K27me3).	Lysine	121-127	H3 clustered histone 7	Mus musculus	93-103
33288023-6	2021	MPK6 activity in roots was enhanced by amino acid treatment, being greater in response to l-Trp while mpk6 mutants supported cell division and elongation at high doses of l-Glu, l-Leu, l-Lys and l-Trp.	Lysine	185-190	MAP kinase 6	Arabidopsis thaliana	0-4
33288023-6	2021	MPK6 activity in roots was enhanced by amino acid treatment, being greater in response to l-Trp while mpk6 mutants supported cell division and elongation at high doses of l-Glu, l-Leu, l-Lys and l-Trp.	Lysine	185-190	MAP kinase 6	Arabidopsis thaliana	102-106
11264280-7	2001	Additionally, we show that PAI-1 inhibition of the Lys(37)-Lys(38)-Lys(39) --&gt; Pro-Gln-Glu mutant of APC is severely impaired, suggesting that, similar to tissue plasminogen activator, the basic 39-loop of APC plays a critical role in the reaction.	Lysine	59-62	serpin family E member 1	Homo sapiens	27-32
27831563-8	2016	Using this original approach, we demonstrate that the tPA binds the NTD of the GluN1 subunit at a lysine in position 178.	Lysine	98-104	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	79-84
11331016-0	2001	Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.	Lysine	17-23	solute carrier family 22 member 8	Rattus norvegicus	102-107
11331016-9	2001	These data indicate that arginine 454 and lysine 370 are essential for the anion specificity of rOAT3.	Lysine	42-48	solute carrier family 22 member 8	Rattus norvegicus	96-101
33456568-1	2021	Rationale: The Jumonji domain containing-3 (JMJD3), a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3), is associated with the pathogenesis of many diseases, but its role in renal fibrosis remains unexplored.	Lysine	116-122	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	15-42
33456568-1	2021	Rationale: The Jumonji domain containing-3 (JMJD3), a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3), is associated with the pathogenesis of many diseases, but its role in renal fibrosis remains unexplored.	Lysine	116-122	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	44-49
33396715-8	2020	Notably, we identified the lysine 44 residue of IKKalpha as a putative binding site for STAT3.	Lysine	27-33	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	48-56
27591365-5	2016	Furthermore, about half of the Zfat-binding sites were characterized by histone H3 acetylations at lysine 9 and lysine 27 (H3K9ac/K27ac).	Lysine	99-105	zinc finger and AT-hook domain containing	Homo sapiens	31-35
33396954-4	2020	Bromodomain inhibitors are a class of drugs that target BET (bromodomain and extra-terminal) proteins, impairing their ability to bind to acetylated lysines and therefore interfering with transcriptional initiation and elongation.	Lysine	149-156	delta/notch-like EGF repeat containing	Mus musculus	56-59
33273697-5	2020	PSY1 contains two ubiquitinated lysine residues (Lys380 and Lys406) as revealed by the global analysis and characterization of protein ubiquitination.	Lysine	32-38	phytoene synthase 1, chloroplastic	Solanum lycopersicum	0-4
11278311-10	2001	Finally, molecular modeling predicted that PI-9 Glu(344) forms a salt bridge with Lys(27) of granzyme B, and we showed that a K27A mutant of granzyme B binds less efficiently to PI-9 and to substrates containing a P4" Glu.	Lysine	82-85	granzyme B	Homo sapiens	93-103
11278311-10	2001	Finally, molecular modeling predicted that PI-9 Glu(344) forms a salt bridge with Lys(27) of granzyme B, and we showed that a K27A mutant of granzyme B binds less efficiently to PI-9 and to substrates containing a P4" Glu.	Lysine	82-85	granzyme B	Homo sapiens	141-151
27591365-5	2016	Furthermore, about half of the Zfat-binding sites were characterized by histone H3 acetylations at lysine 9 and lysine 27 (H3K9ac/K27ac).	Lysine	112-118	zinc finger and AT-hook domain containing	Homo sapiens	31-35
27806304-5	2016	We demonstrate that overnutrition facilitates the recruitment of MLL4 to steatotic target genes of PPARgamma2 and their transactivation via H3 lysine 4 methylation because PPARgamma2 phosphorylated by overnutrition-activated ABL1 kinase shows enhanced interaction with MLL4.	Lysine	143-149	lysine (K)-specific methyltransferase 2D	Mus musculus	65-69
11238646-3	2001	We have previously reported that residue Asp(112) of CRP plays a major role in the formation of the C1q-binding site, while the neighboring Lys(114) hinders C1q binding.	Lysine	140-143	complement C1q A chain	Homo sapiens	157-160
32208897-11	2020	As a histone demethylase specific for tri- and dimethylated histone H3 at lysine 4 (H3K4me3/me2), KDM5A deficiency led to a significant increment in total H3K4me3 levels, whereas no significant difference was found for H3K4 me2.	Lysine	74-80	lysine demethylase 5A	Homo sapiens	98-103
27541483-3	2016	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of lysine residues in fibrillar collagen telopeptides.	Lysine	98-104	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	Danio rerio	0-5
33244015-3	2020	DOT1L methylates lysine 79 in the globular domain of histone H3 (H3K79).	Lysine	17-23	H3 clustered histone 7	Mus musculus	53-63
11242053-0	2001	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.	Lysine	26-32	defensin alpha 1	Homo sapiens	62-65
11242053-3	2001	Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.	Lysine	88-94	defensin alpha 1	Homo sapiens	142-145
27541483-3	2016	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of lysine residues in fibrillar collagen telopeptides.	Lysine	98-104	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	Danio rerio	18-37
27541483-3	2016	PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of lysine residues in fibrillar collagen telopeptides.	Lysine	98-104	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	Danio rerio	39-42
27670594-9	2016	Mechanistically, VSMC-SIRT1-dependent deacetylation of histone H3 lysine 9 on the matrix metallopeptidase 2 (Mmp2) promoter was required for CR-mediated suppression of AngII-induced MMP2 expression.	Lysine	66-72	sirtuin 1	Mus musculus	22-27
11067849-1	2001	After the nucleotide binding domain in sarcoplasmic reticulum Ca2+-ATPase has been derivatized with fluorescein isothiocyanate at Lys-515, ATPase phosphorylation in the presence of a calcium gradient, with Ca2+ on the lumenal side but without Ca2+ on the cytosolic side, results in the formation of a species that exhibits exceptionally low probe fluorescence (Pick, U.	Lysine	130-133	protein interacting with PRKCA 1	Homo sapiens	361-365
33217972-5	2020	Our findings revealed that CPZ has a strict requirement for substrates with C-terminal Arg or Lys at the P1" position.	Lysine	94-97	carboxypeptidase Z	Homo sapiens	27-30
27572307-1	2016	SETDB2 is a histone H3 lysine 9 (H3K9) tri-methyltransferase that is involved in transcriptional gene silencing.	Lysine	23-29	SET domain bifurcated histone lysine methyltransferase 2	Homo sapiens	0-6
33203140-3	2020	This mutation was found only once in control databases; the mutated lysine is located in the Cav1.2 calcium channel, is highly conserved during evolution, and is predicted to affect protein function by most pathogenicity prediction algorithms.	Lysine	68-74	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	93-99
11360998-4	2001	Compared to the wild-type hsc70, the mutant was more accessible to cleavage by endopeptidase Lys-C, implying that the overall structure of hsc70(R469C) is relatively loose.	Lysine	93-96	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	139-144
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	134-140	formyl peptide receptor 2	Homo sapiens	57-61
11163131-3	2001	This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.	Lysine	62-68	kinesin family member 1A	Homo sapiens	82-87
11163131-3	2001	This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.	Lysine	62-68	kinesin family member 1A	Homo sapiens	254-259
33282879-4	2020	We demonstrate that recombinant NEDD4L stimulates ubiquitylation of OGG1 in vitro, particularly on lysine 341, and that NEDD4L and OGG1 interact in U2OS cells.	Lysine	99-105	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	32-38
33016573-3	2020	NDIME interacts with EZH2, the major component of polycomb repressive complex 2 (PRC2), and blocks EZH2-mediated trimethylation of histone H3 lysine 27 (H3K27me3) at the Mef2c promoter, promoting MEF2C transcription.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	21-25
33016573-3	2020	NDIME interacts with EZH2, the major component of polycomb repressive complex 2 (PRC2), and blocks EZH2-mediated trimethylation of histone H3 lysine 27 (H3K27me3) at the Mef2c promoter, promoting MEF2C transcription.	Lysine	142-148	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	99-103
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	166-172	formyl peptide receptor 2	Homo sapiens	57-61
27424221-4	2016	We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3.	Lysine	166-172	formyl peptide receptor 2	Homo sapiens	57-61
27423420-2	2016	SIRT3, a mitochondria-localized sirtuin, regulates global mitochondrial lysine acetylation and preserves mitochondrial function.	Lysine	72-78	sirtuin 3	Mus musculus	0-5
33086047-7	2020	Furthermore, we provide evidence that the conserved beta-3 strand lysine of protein kinases (Lys111 of PDK1) functions as an integrator node to coordinate allosteric coupling of the two ligand-binding sites.	Lysine	66-72	pyruvate dehydrogenase kinase 1	Homo sapiens	103-107
11170382-8	2001	In this framework, we suggest that (1) in the actin-myosin association phase, cationic residues Lys-576 and Lys-578 interact with anionic residues of the so-called second actin, and (2) in the product leaving phase, hydrophobic residues Trp-546, Phe-547, and Pro-548, as well as the Thr-532/Asn-533/Pro-534/Pro-535 sequence, sever connections with the so-called first actin.	Lysine	96-99	myosin heavy chain 14	Homo sapiens	52-58
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	catenin beta 1	Homo sapiens	90-102
11170382-8	2001	In this framework, we suggest that (1) in the actin-myosin association phase, cationic residues Lys-576 and Lys-578 interact with anionic residues of the so-called second actin, and (2) in the product leaving phase, hydrophobic residues Trp-546, Phe-547, and Pro-548, as well as the Thr-532/Asn-533/Pro-534/Pro-535 sequence, sever connections with the so-called first actin.	Lysine	108-111	myosin heavy chain 14	Homo sapiens	52-58
11104695-1	2000	Deoxyhypusine synthase catalyses the NAD-dependent transfer of the butylamine moiety from the polyamine, spermidine, to a specific lysine residue of a single cellular protein, eukaryotic translation-initiation factor 5A (eIF5A) precursor.	Lysine	131-137	eukaryotic translation initiation factor 5A	Homo sapiens	176-219
32738274-7	2020	Exposure of hSP-D to CSE or acrolein induced an increased higher-molecular -weight of hSP-D and acrolein induced modification of five lysine residues in hSP-D.	Lysine	134-140	surfactant protein D	Homo sapiens	12-17
11104695-1	2000	Deoxyhypusine synthase catalyses the NAD-dependent transfer of the butylamine moiety from the polyamine, spermidine, to a specific lysine residue of a single cellular protein, eukaryotic translation-initiation factor 5A (eIF5A) precursor.	Lysine	131-137	eukaryotic translation initiation factor 5A	Homo sapiens	221-226
27528606-6	2016	However, Imp5, Imp7, Imp9, and Impalpha bind two separate elements in the H3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.	Lysine	131-137	importin 9	Homo sapiens	21-25
11154116-8	2000	It included residues Lys 165, Lys 166, Asn199, Arg200 and Lys201 and thus overlapped with the substrate interaction region of tissue factor.	Lysine	21-24	coagulation factor III, tissue factor	Homo sapiens	126-139
33070155-7	2020	We demonstrate that RNF40-driven H2B monoubiquitination is essential for transcriptional activation of RHO/ROCK/LIMK pathway components and proper actin-cytoskeleton dynamics through a trans-histone crosstalk with histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	224-230	ring finger protein 40	Mus musculus	20-25
11154116-8	2000	It included residues Lys 165, Lys 166, Asn199, Arg200 and Lys201 and thus overlapped with the substrate interaction region of tissue factor.	Lysine	30-33	coagulation factor III, tissue factor	Homo sapiens	126-139
33060649-1	2020	Mutant RAS genes play an important role in regulating tumors through lysine residue 104 to impair GEF-induced nucleotide exchange, but the regulatory role of KRAS K104 modification on the KRASG12D mutant remains unclear.	Lysine	69-75	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	98-101
27528606-6	2016	However, Imp5, Imp7, Imp9, and Impalpha bind two separate elements in the H3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.	Lysine	131-137	inositol monophosphatase 1	Homo sapiens	31-39
27685940-1	2016	Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo.	Lysine	111-117	uncoupling protein 1	Homo sapiens	53-56
32763975-5	2020	Here, we present evidence that FAAP20 is acetylated by the acetyltransferase p300/CBP on lysine 152, the key residue which when polyubiquitinated results in the degradation of FAAP20.	Lysine	89-95	FA core complex associated protein 20	Homo sapiens	31-37
32763975-5	2020	Here, we present evidence that FAAP20 is acetylated by the acetyltransferase p300/CBP on lysine 152, the key residue which when polyubiquitinated results in the degradation of FAAP20.	Lysine	89-95	FA core complex associated protein 20	Homo sapiens	176-182
32763975-6	2020	Acetylation or mutation of the lysine residue stabilizes FAAP20 by preventing its ubiquitination, thereby protecting it from proteasome-dependent FAAP20 degradation.	Lysine	31-37	FA core complex associated protein 20	Homo sapiens	57-63
11098085-1	2000	Deoxyhypusine synthase is the key enzyme for modifying a lysine residue to hypusine in the cellular protein eukaryotic initiation factor 5A (eIF-5A).	Lysine	57-63	deoxyhypusine synthase	Mus musculus	0-22
11443278-11	2000	Whereas OST48 carries a double-lysine motif in the -3/-5 position of its cytosolic C-terminal domain, ribophorin I does not contain recognizable ER-retention information.	Lysine	31-37	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Sus scrofa	8-13
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Lysine	96-99	thrombomodulin	Homo sapiens	21-35
32763975-6	2020	Acetylation or mutation of the lysine residue stabilizes FAAP20 by preventing its ubiquitination, thereby protecting it from proteasome-dependent FAAP20 degradation.	Lysine	31-37	FA core complex associated protein 20	Homo sapiens	146-152
32763975-8	2020	Together, our study reveals a competition mechanism between ubiquitination and acetylation of a common lysine residue that controls FAAP20 stability and highlights a complex balancing between different posttranslational modifications as a way to refine the FA pathway signaling required for DNA ICL repair and genome stability.	Lysine	103-109	FA core complex associated protein 20	Homo sapiens	132-138
11015210-2	2000	In this paper, we show that virtually all the preference is mediated through 3 (Lys-53, -56, and -120) of the 12 cationic residues of bovine pancreatic PLA2.	Lysine	80-83	LOC104974671	Bos taurus	152-156
27685940-1	2016	Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo.	Lysine	175-181	uncoupling protein 1	Homo sapiens	53-56
27685940-4	2016	The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination.	Lysine	127-134	uncoupling protein 1	Homo sapiens	55-58
32394628-1	2020	Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing tri-methylation marks at lysine 27 of histone H3 (H3K27me3).	Lysine	278-284	embryonic ectoderm development	Homo sapiens	147-150
27685940-4	2016	The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination.	Lysine	127-134	uncoupling protein 1	Homo sapiens	107-110
27688818-2	2016	Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated.	Lysine	0-6	proliferating cell nuclear antigen	Homo sapiens	50-84
11015210-6	2000	The results show that lysine-to-methionine substitution induces a structural change that promotes the binding of PLA2 to the interface as well as the substrate binding to the enzyme at the interface.	Lysine	22-28	LOC104974671	Bos taurus	113-117
27688818-2	2016	Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated.	Lysine	0-6	proliferating cell nuclear antigen	Homo sapiens	86-90
32868907-2	2020	LSD1 (KDM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K4me1/2)5,6, but also acts as a steroid hormone receptor coactivator through mechanisms that are unclear.	Lysine	95-101	lysine demethylase 1A	Homo sapiens	0-4
27471269-9	2016	We conclude that the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region.	Lysine	126-129	retinal degeneration 3	Mus musculus	53-56
32868907-2	2020	LSD1 (KDM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K4me1/2)5,6, but also acts as a steroid hormone receptor coactivator through mechanisms that are unclear.	Lysine	95-101	lysine demethylase 1A	Homo sapiens	6-11
32868907-4	2020	Mechanistically, we demonstrate that LSD1 positively regulates FOXA1 binding by demethylating lysine 270, adjacent to the wing2 region of the FOXA1 DNA-binding domain.	Lysine	94-100	lysine demethylase 1A	Homo sapiens	37-41
32895492-4	2020	BRD3 binds to histone H3 acetylated at lysine 18 (H3K18ac) in vitro and co-occupies the genome with H3K18ac.	Lysine	39-45	bromodomain containing 3	Homo sapiens	0-4
11020758-5	2000	Using site-directed mutagenesis, the authors created point mutations at positions hH1-F1760, hH1-N1765, hH1-Y1767, and hH1-N406 by introducing the positively charged lysine (K) or the negatively charged aspartic acid (D) and studied their influence on state-dependent block by bupivacaine enantiomers.	Lysine	166-172	H1.5 linker histone, cluster member	Homo sapiens	82-85
11020758-5	2000	Using site-directed mutagenesis, the authors created point mutations at positions hH1-F1760, hH1-N1765, hH1-Y1767, and hH1-N406 by introducing the positively charged lysine (K) or the negatively charged aspartic acid (D) and studied their influence on state-dependent block by bupivacaine enantiomers.	Lysine	166-172	H1.5 linker histone, cluster member	Homo sapiens	93-96
11020758-5	2000	Using site-directed mutagenesis, the authors created point mutations at positions hH1-F1760, hH1-N1765, hH1-Y1767, and hH1-N406 by introducing the positively charged lysine (K) or the negatively charged aspartic acid (D) and studied their influence on state-dependent block by bupivacaine enantiomers.	Lysine	166-172	H1.5 linker histone, cluster member	Homo sapiens	93-96
11020758-5	2000	Using site-directed mutagenesis, the authors created point mutations at positions hH1-F1760, hH1-N1765, hH1-Y1767, and hH1-N406 by introducing the positively charged lysine (K) or the negatively charged aspartic acid (D) and studied their influence on state-dependent block by bupivacaine enantiomers.	Lysine	166-172	H1.5 linker histone, cluster member	Homo sapiens	93-96
27455358-0	2016	Nuclear Magnetic Resonance Observation of alpha-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.	Lysine	127-133	synuclein alpha	Homo sapiens	42-57
10982821-1	2000	Hat1p and Hat2p are the two subunits of a type B histone acetyltransferase from Saccharomyces cerevisiae that acetylates free histone H4 on lysine 12 in vitro.	Lysine	140-146	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	0-5
10982821-10	2000	Mutational analysis of the histone H4 tail indicated that the role of Hat1p in telomeric silencing was mediated solely through lysine 12.	Lysine	127-133	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	70-75
32731005-1	2020	Enhancer of zeste homolog 2 (EZH2) is a histone H3 lysine 27 (H3K27) methyltransferase that plays vital roles in mouse spermatogenesis.	Lysine	51-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
32731005-1	2020	Enhancer of zeste homolog 2 (EZH2) is a histone H3 lysine 27 (H3K27) methyltransferase that plays vital roles in mouse spermatogenesis.	Lysine	51-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	lysine demethylase 6B	Homo sapiens	151-156
32817139-1	2020	Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3).	Lysine	91-97	lysine demethylase 6B	Homo sapiens	158-163
27586085-7	2016	Deacetylase SIRT2 promotes NADPH production through deacetylating G6PD at lysine 403 (K403).	Lysine	74-80	sirtuin 2	Homo sapiens	12-17
32978498-5	2020	Using immunoaffinity purification coupled with liquid chromatography-high resolution tandem mass spectrometry, we have discovered that mature frataxin in mouse heart (77%), brain (86%), and liver (47%) is predominantly a 129-amino acid truncated mature frataxin (79-207) in which the N-terminal lysine residue has been lost.	Lysine	295-301	frataxin	Mus musculus	142-150
32537908-4	2020	A FA-reactive lysine analogue, PrAK, was site-specifically incorporated into the essential lysine sites of enhanced green fluorescent protein (EGFP) and firefly luciferase (fLuc) to afford the fluorescent and luminescent probes, respectively.	Lysine	14-20	MAPK activated protein kinase 5	Homo sapiens	31-35
11014199-2	2000	Dosage compensation is an epigenetic process involving the specific acetylation of histone H4 at lysine 16 by the histone acetyltransferase MOF.	Lysine	97-103	males absent on the first	Drosophila melanogaster	140-143
10987285-4	2000	Despite the recent biochemical evidence that maspin specifically inhibits tissue-type plasminogen activator that is associated with fibrinogen or poly-L-lysine, the molecular mechanism underlying the tumor-suppressive effect of maspin remains elusive.	Lysine	146-159	serpin family B member 5	Homo sapiens	45-51
10859319-7	2000	MMP-7 and MMP-9 cleaved TFPI at Lys(20)-Leu(21) with additional COOH-terminal processing.	Lysine	32-35	matrix metallopeptidase 7	Homo sapiens	0-5
32537908-4	2020	A FA-reactive lysine analogue, PrAK, was site-specifically incorporated into the essential lysine sites of enhanced green fluorescent protein (EGFP) and firefly luciferase (fLuc) to afford the fluorescent and luminescent probes, respectively.	Lysine	91-97	MAPK activated protein kinase 5	Homo sapiens	31-35
33088284-0	2020	Hypoxia-Inducible Lysine Methyltransferases: G9a and GLP Hypoxic Regulation, Non-histone Substrate Modification, and Pathological Relevance.	Lysine	18-24	euchromatic histone lysine methyltransferase 2	Homo sapiens	45-48
33088284-6	2020	Recently, these oxygen sensors have also been found to suppress the function of two lysine methyltransferases, G9a and G9a-like protein (GLP).	Lysine	84-90	euchromatic histone lysine methyltransferase 2	Homo sapiens	111-114
33088284-8	2020	Furthermore, G9a and GLP elicit lysine methylation on a wide variety of non-histone proteins, many of which are known to be regulated by hypoxia.	Lysine	32-38	euchromatic histone lysine methyltransferase 2	Homo sapiens	13-16
27208501-4	2016	The TIS21-mediated switch of senescence to apoptosis was accompanied by nuclear translocation of p53 protein and its modifications on Ser-15 and Ser-46 phosphorylation and acetylations on Lys-120, -320, -373 and -382 residues.	Lysine	188-191	BTG anti-proliferation factor 2	Homo sapiens	4-9
32677374-7	2020	Furthermore, this study also revealed the mechanism underlying the recruitment of TRIM24 by the DANCR/KAT6A complex, which is bound to acetylated lysine 23 of histone H3 (H3K23), resulting in binding to the YAP promoter and activation of YAP transcription that ultimately enhances the proliferation of colorectal cancer cells.	Lysine	146-152	tripartite motif containing 24	Homo sapiens	82-88
10964656-3	2000	We constructed stable clones of C6 cells transfected with two types of IkappaBalpha mutant genes (IkappaBalpha(SS --&gt; AA); Ser-32/36 to Ala-32/36, IkappaBalpha(KK --&gt; RR); Lys-21/22 to Arg-21/22).	Lysine	178-181	NFKB inhibitor alpha	Rattus norvegicus	71-83
10964656-7	2000	These results suggest that another Lys residue(s), other than Lys-21/22, may be required for the ligand-induced IkappaBalpha degradation by the ubiquitin-proteasome pathway.	Lysine	35-38	NFKB inhibitor alpha	Rattus norvegicus	112-124
25693640-3	2016	The positive charges of the lysine residues on the cell-penetrating peptides (CPPs) were temporarily caged by the photolabile-protective groups (PG), thereby forming a PSP.	Lysine	28-34	persephin	Mus musculus	168-171
10807912-9	2000	Degradation of both wild type and lysine-less protein is sensitive to fusion of a Myc tag to the N terminus of LMP1.	Lysine	34-40	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-85
32565234-0	2020	Retraction notice to "Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16" [Life Sci.	Lysine	154-160	KRAS proto-oncogene, GTPase	Homo sapiens	36-40
27380180-2	2016	Following the conversion of a lysine residue on eIF5A to deoxyhypusine (Dhp) by deoxyhypusine synthase, hDOHH hydroxylates Dhp to yield the unusual amino acid residue hypusine (Hpu), a modification that is essential for eIF5A to promote peptide synthesis at the ribosome, among other functions.	Lysine	30-36	eukaryotic translation initiation factor 5A	Homo sapiens	48-53
32647014-5	2020	Surprisingly, this analysis revealed that mutation of three lysine residues in the lyase active site of pol beta, 35, 68, and 72, to alanine (pol beta KDelta3A) increased the binding affinity for nonspecific DNA ~11-fold compared with that of the WT.	Lysine	60-66	polymerase (DNA directed), alpha 1	Mus musculus	104-112
32647014-5	2020	Surprisingly, this analysis revealed that mutation of three lysine residues in the lyase active site of pol beta, 35, 68, and 72, to alanine (pol beta KDelta3A) increased the binding affinity for nonspecific DNA ~11-fold compared with that of the WT.	Lysine	60-66	polymerase (DNA directed), alpha 1	Mus musculus	142-150
32647014-8	2020	These data suggest that the three lysines in the lyase active site destabilize pol beta when bound to DNA nonspecifically, promoting DNA scanning and providing binding specificity for gapped DNA.	Lysine	34-41	polymerase (DNA directed), alpha 1	Mus musculus	79-87
10924102-4	2000	A Dpn mutant containing the unnatural amino acid norleucine in place of lysine at position 80 in the bHLH loop region is not inhibited by the polyamide, suggesting that the epsilon amino group at this position is responsible for DNA contacts outside the major groove.	Lysine	72-78	deadpan	Drosophila melanogaster	2-5
27380180-2	2016	Following the conversion of a lysine residue on eIF5A to deoxyhypusine (Dhp) by deoxyhypusine synthase, hDOHH hydroxylates Dhp to yield the unusual amino acid residue hypusine (Hpu), a modification that is essential for eIF5A to promote peptide synthesis at the ribosome, among other functions.	Lysine	30-36	deoxyhypusine hydroxylase	Homo sapiens	104-109
10952103-8	2000	This A/C polymorphism, which may affect mRNA stability for ERCC1, also results in an amino acid substitution of lysine to glutamine in a recently described nucleolar protein (ASE-1) and T-cell receptor complex subunit CD3epsilon-associated signal transducer (CAST).	Lysine	112-118	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	59-64
10952103-8	2000	This A/C polymorphism, which may affect mRNA stability for ERCC1, also results in an amino acid substitution of lysine to glutamine in a recently described nucleolar protein (ASE-1) and T-cell receptor complex subunit CD3epsilon-associated signal transducer (CAST).	Lysine	112-118	RNA polymerase I subunit G	Homo sapiens	175-180
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	lysine demethylase 3A	Homo sapiens	51-57
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	lysine demethylase 3A	Homo sapiens	142-148
10952103-8	2000	This A/C polymorphism, which may affect mRNA stability for ERCC1, also results in an amino acid substitution of lysine to glutamine in a recently described nucleolar protein (ASE-1) and T-cell receptor complex subunit CD3epsilon-associated signal transducer (CAST).	Lysine	112-118	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	218-228
32522824-6	2020	Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets.	Lysine	61-67	lysine demethylase 3A	Homo sapiens	142-148
27380180-2	2016	Following the conversion of a lysine residue on eIF5A to deoxyhypusine (Dhp) by deoxyhypusine synthase, hDOHH hydroxylates Dhp to yield the unusual amino acid residue hypusine (Hpu), a modification that is essential for eIF5A to promote peptide synthesis at the ribosome, among other functions.	Lysine	30-36	eukaryotic translation initiation factor 5A	Homo sapiens	220-225
27570077-3	2016	Here we show that the non-canonical conjugating enzyme Ubc6 attaches single Ub molecules not only to lysines but also to hydroxylated amino acids.	Lysine	101-108	ubiquitin conjugating enzyme E2 J1	Homo sapiens	55-59
32747411-2	2020	The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3.	Lysine	111-117	host cell factor C1	Homo sapiens	198-203
32747411-2	2020	The mammalian Polycomb repressive de-ubiquitinase (PR-DUB) complexes catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119Ub1) through a multi-protein core comprised of BAP1, HCFC1, FOXK1/2, and OGT in combination with either of ASXL1, 2 or 3.	Lysine	111-117	ASXL transcriptional regulator 1	Homo sapiens	252-257
32703935-6	2020	HSD17B10 is acetylated at lysine residues K79, K99 and K105 by the acetyltransferase CBP, and the acetylation is reversed by SIRT3.	Lysine	26-32	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	0-8
11035260-1	2000	The thioredoxins are ubiquitous proteins containing a conserved -Trp-Cys-Gly-Pro-Cys-Lys- redox catalytic site.	Lysine	85-88	thioredoxin	Homo sapiens	4-16
27486845-0	2016	Relocating the Active-Site Lysine in Rhodopsin: 2.	Lysine	27-33	rhodopsin	Bos taurus	37-46
10887113-7	2000	Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment.	Lysine	59-62	plasminogen activator, urokinase receptor	Homo sapiens	102-106
10887113-7	2000	Through these interactions, HKa or its recombinant His-Gly-Lys-rich domain 5 completely inhibited the uPAR-dependent adhesion of myelomonocytic U937 cells and uPAR-transfected BAF-3 cells to VN and thereby promoted cell detachment.	Lysine	59-62	plasminogen activator, urokinase receptor	Homo sapiens	159-163
32647127-5	2020	We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.	Lysine	17-23	lysine acetyltransferase 5	Homo sapiens	42-47
27486845-2	2016	The visual pigment rhodopsin is a G protein-coupled receptor that covalently binds its retinal chromophore via a Schiff base linkage to an active-site Lys residue in the seventh transmembrane helix.	Lysine	151-154	rhodopsin	Bos taurus	19-28
27486845-3	2016	Although this residue is strictly conserved among all type II retinylidene proteins, we found previously that the active-site Lys in bovine rhodopsin (Lys296) can be moved to three other locations (G90K, T94K, S186K) while retaining the ability to form a pigment with retinal and to activate transducin in a light-dependent manner [ Devine et al.	Lysine	126-129	rhodopsin	Bos taurus	140-149
32198816-0	2020	Yin Yang-1 suppresses CD40 ligand-CD40 signaling mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter.	Lysine	191-197	interleukin 10	Homo sapiens	85-99
27486845-13	2016	These results demonstrate that rhodopsin can tolerate a second Lys in the retinal binding pocket and suggest that an evolutionary intermediate with two Lys could allow migration of the Schiff base Lys to a position other than the observed, highly conserved location in the seventh TM helix.	Lysine	63-66	rhodopsin	Bos taurus	31-40
32198816-0	2020	Yin Yang-1 suppresses CD40 ligand-CD40 signaling mediated anti-inflammatory cytokine interleukin-10 expression in pulmonary adventitial fibroblasts by promoting histone H3 tri-methylation at lysine 27 modification on interleukin-10 promoter.	Lysine	191-197	interleukin 10	Homo sapiens	217-231
27486845-13	2016	These results demonstrate that rhodopsin can tolerate a second Lys in the retinal binding pocket and suggest that an evolutionary intermediate with two Lys could allow migration of the Schiff base Lys to a position other than the observed, highly conserved location in the seventh TM helix.	Lysine	152-155	rhodopsin	Bos taurus	31-40
27486845-13	2016	These results demonstrate that rhodopsin can tolerate a second Lys in the retinal binding pocket and suggest that an evolutionary intermediate with two Lys could allow migration of the Schiff base Lys to a position other than the observed, highly conserved location in the seventh TM helix.	Lysine	152-155	rhodopsin	Bos taurus	31-40
10871638-14	2000	The CO2/pH sensitivities were related to a lysine residue in the NH2 terminus of Kir4.1.	Lysine	43-49	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	81-87
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	POU class 5 homeobox 1	Homo sapiens	44-48
32515589-3	2020	Herein, we report an O18-labeling assisted LC-MS method, which takes advantage of the carboxypeptidase B-catalyzed Lys removal and O18-labeling, to achieve improved accuracy of C-term Lys quantitation.	Lysine	115-118	carboxypeptidase B1	Homo sapiens	86-104
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	POU class 5 homeobox 1	Homo sapiens	107-111
32515589-3	2020	Herein, we report an O18-labeling assisted LC-MS method, which takes advantage of the carboxypeptidase B-catalyzed Lys removal and O18-labeling, to achieve improved accuracy of C-term Lys quantitation.	Lysine	184-187	carboxypeptidase B1	Homo sapiens	86-104
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Lysine	10-17	low density lipoprotein receptor	Homo sapiens	138-170
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	POU class 5 homeobox 1	Homo sapiens	107-111
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Lysine	10-17	low density lipoprotein receptor	Homo sapiens	172-176
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	POU class 5 homeobox 1	Homo sapiens	107-111
32163596-6	2020	ATM represses DSB-induced expression of senescence-associated genes, including the genes encoding the WRKY and NAC transcription factors, central components of the leaf senescence process, via modulation of histone lysine methylation.	Lysine	215-221	Serine/Threonine-kinase ATM-like protein	Arabidopsis thaliana	0-3
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	POU class 5 homeobox 1	Homo sapiens	44-48
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	POU class 5 homeobox 1	Homo sapiens	107-111
10928473-4	2000	Binding and competition experiments indicated that the interaction involves the region comprising the first 3 kringles of plasminogen and the COOH-terminal lysine-rich domain of MIP-2alpha.	Lysine	156-162	C-X-C motif chemokine ligand 2	Homo sapiens	178-188
32518374-4	2020	Here, we report that lysine (K) 426 on WSTF is acetylated by MOF and deacetylated by SIRT1.	Lysine	21-27	sirtuin 1	Homo sapiens	85-90
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	POU class 5 homeobox 1	Homo sapiens	107-111
32647649-1	2020	Lysine-specific histone demethylase 1 (LSD1), also known as KDM1A, can remove the methyl group from lysine 4 and 9 at histone H3, which regulates transcriptional suppression and activation.	Lysine	100-106	lysine demethylase 1A	Homo sapiens	0-37
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	POU class 5 homeobox 1	Homo sapiens	107-111
32647649-1	2020	Lysine-specific histone demethylase 1 (LSD1), also known as KDM1A, can remove the methyl group from lysine 4 and 9 at histone H3, which regulates transcriptional suppression and activation.	Lysine	100-106	lysine demethylase 1A	Homo sapiens	39-43
32647649-1	2020	Lysine-specific histone demethylase 1 (LSD1), also known as KDM1A, can remove the methyl group from lysine 4 and 9 at histone H3, which regulates transcriptional suppression and activation.	Lysine	100-106	lysine demethylase 1A	Homo sapiens	60-65
27405757-5	2016	The present work identifies a key role for Lys(66) in the regulation of PTEN expression and provides both an opportunity to improve the stability of PTEN as a protein therapy and a mechanistic basis for efforts to stabilize endogenous PTEN.	Lysine	43-46	phosphatase and tensin homolog	Homo sapiens	149-153
10770943-5	2000	PDZ2 mutations have more pronounced effects on binding than PDZ1 mutations, but complete abrogation of syntenin-syndecan binding requires the combination of both the lysine and the alphaB1 mutations in both the PDZ domains of syntenin.	Lysine	166-172	syndecan binding protein	Homo sapiens	103-111
27405757-5	2016	The present work identifies a key role for Lys(66) in the regulation of PTEN expression and provides both an opportunity to improve the stability of PTEN as a protein therapy and a mechanistic basis for efforts to stabilize endogenous PTEN.	Lysine	43-46	phosphatase and tensin homolog	Homo sapiens	149-153
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	10-16	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	146-153
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	10-16	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	164-171
27525512-3	2016	UBP12 binds to chromatin of PcG target genes and is required for histone H3 lysine 27 trimethylation and repression of a subset of PcG target genes.	Lysine	76-82	ubiquitin-specific protease 12	Arabidopsis thaliana	0-5
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	93-99	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	146-153
32552762-9	2020	Moreover, lysine-specific histone demethylase 5C(KDM5C)-mediated demethylation of histone H3 lysine 4 tri-methylation(H3K4me3) in the promoter of METTL14 inhibited METTL14 transcription.	Lysine	93-99	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	164-171
32541668-2	2020	We find that heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein-1) associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.	Lysine	46-52	Brca1 associated protein 1	Mus musculus	72-76
10856234-3	2000	In this study, we report SH3 domain binding to a novel proline-independent motif in immune cell adaptor SKAP55, which is comprised of two N-terminal lysine and arginine residues followed by two tyrosines (i.e. RKxxYxxY).	Lysine	149-155	src kinase associated phosphoprotein 1	Homo sapiens	104-110
10751404-7	2000	We also found that a conserved Lys residue required for PP5 binding to hsp90 was critical for the binding of FKBP52 but not for the binding of Hop to hsp90.	Lysine	31-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	71-76
32541668-2	2020	We find that heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein-1) associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.	Lysine	46-52	Brca1 associated protein 1	Mus musculus	78-104
27247267-3	2016	In this study, we show that Rtr1 is a global regulator of the CTD code with deletion of RTR1 causing genome-wide changes in Ser5-P CTD phosphorylation and cotranscriptional histone H3 lysine 36 trimethylation (H3K36me3).	Lysine	184-190	RNA polymerase II associated protein 2	Homo sapiens	28-32
32626783-5	2020	rs5498 is a nonsynonymous SNP and caused by substitution between E (Glu) and K (Lys) for ICAM-1 protein.	Lysine	80-83	intercellular adhesion molecule 1	Homo sapiens	89-95
10821679-1	2000	The mitochondrial protein horse heart cytochrome c was specifically spin-labeled with succinimidyl-2,2,5, 5-tetramethyl-3-pyrroline-1-oxyl-carboxylate on different lysine residues at positions 86, 87, 72, 8, or 25, respectively.	Lysine	164-170	cytochrome c, somatic	Equus caballus	38-50
27325702-6	2016	In vitro ubiquitination/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the ACR residues Lys(649/650/651/676/688) Deletion of Crbn reduces ubiquitination of Lys(676) suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro ubiquitination of presynaptic proteins that regulate exocytosis, suggesting a mechanism by which APP tunes transmitter release.	Lysine	135-138	interleukin 17 receptor B	Homo sapiens	273-277
10760305-5	2000	hot1 was found to have a mutation in the heat shock protein 101 (Hsp101) gene, converting a conserved Glu residue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise Hsp101 ATPase activity.	Lysine	152-155	heat shock protein 101	Arabidopsis thaliana	41-63
10760305-5	2000	hot1 was found to have a mutation in the heat shock protein 101 (Hsp101) gene, converting a conserved Glu residue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise Hsp101 ATPase activity.	Lysine	152-155	heat shock protein 101	Arabidopsis thaliana	65-71
32527012-3	2020	STRAP is acetylated at lysines 147, 148, and 156 by the acetyltransferases CREB-binding protein (CBP) and that the acetylation is reversed by the deacetylase sirtuin7 (SIRT7).	Lysine	23-30	sirtuin 7	Homo sapiens	158-166
10760305-5	2000	hot1 was found to have a mutation in the heat shock protein 101 (Hsp101) gene, converting a conserved Glu residue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise Hsp101 ATPase activity.	Lysine	152-155	heat shock protein 101	Arabidopsis thaliana	208-214
26657153-6	2016	Mechanistically, we identified that MST1 could be acetylated on its lysine 35 residue in the cells.	Lysine	68-74	macrophage stimulating 1	Homo sapiens	36-40
10759847-0	2000	The C1-C2 interface residue lysine 50 of pig kidney fructose-1, 6-bisphosphatase has a crucial role in the cooperative signal transmission of the AMP inhibition.	Lysine	28-34	fructose-bisphosphatase 1	Sus scrofa	52-80
10692329-0	2000	Dynamics at Lys-553 of the acto-myosin interface in the weakly and strongly bound states.	Lysine	12-15	myosin heavy chain 14	Homo sapiens	32-38
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	141-144	vitronectin	Homo sapiens	269-278
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	244-247	vitronectin	Homo sapiens	269-278
32301534-0	2020	SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation.	Lysine	90-96	mitochondrial antiviral signaling protein	Mus musculus	66-70
32301534-4	2020	Mass spectrometric analysis indicated that Lysine 7 of MAVS is succinylated.	Lysine	43-49	mitochondrial antiviral signaling protein	Mus musculus	55-59
32301534-5	2020	SIRT5-catalyzed desuccinylation of MAVS at Lysine 7 diminishes the formation of MAVS aggregation after viral infection, resulting in the inhibition of MAVS activation and leading to the impairment of type I IFN production and antiviral gene expression.	Lysine	43-49	mitochondrial antiviral signaling protein	Mus musculus	35-39
32301534-5	2020	SIRT5-catalyzed desuccinylation of MAVS at Lysine 7 diminishes the formation of MAVS aggregation after viral infection, resulting in the inhibition of MAVS activation and leading to the impairment of type I IFN production and antiviral gene expression.	Lysine	43-49	mitochondrial antiviral signaling protein	Mus musculus	80-84
27462807-3	2016	RNF168 ubiquitinates H2A on lysine 13 and lysine 15 (refs 7, 8) (yielding H2AK13ub and H2AK15ub, respectively), an event that triggers the recruitment of 53BP1 (also known as TP53BP1) to chromatin flanking DSBs.	Lysine	28-34	tumor protein p53 binding protein 1	Homo sapiens	154-159
32324084-1	2020	Ring1 and Yin Yang 1-Binding Protein (RYBP) is a member of non-canonical polycomb repressive complex 1 to mediate monoubiquitination of histone H2A at lysine 119.	Lysine	151-157	RING1 and YY1 binding protein	Mus musculus	38-42
10692329-1	2000	Lys-553 of skeletal muscle myosin subfragment 1 (S1) was specifically labeled with the fluorescent probe FHS (6-[fluorescein-5(and 6)-carboxamido]hexanoic acid succinimidyl ester) and fluorescence quenching experiments were carried out to determine the accessibility of this probe at Lys-553 in both the strongly and weakly actin-bound states of the MgATPase cycle.	Lysine	0-3	myosin heavy chain 14	Homo sapiens	27-33
10692329-1	2000	Lys-553 of skeletal muscle myosin subfragment 1 (S1) was specifically labeled with the fluorescent probe FHS (6-[fluorescein-5(and 6)-carboxamido]hexanoic acid succinimidyl ester) and fluorescence quenching experiments were carried out to determine the accessibility of this probe at Lys-553 in both the strongly and weakly actin-bound states of the MgATPase cycle.	Lysine	284-287	myosin heavy chain 14	Homo sapiens	27-33
10692329-6	2000	Thus, the lower 50 kD subdomain of myosin containing Lys-553 appears to interact differently with actin in the weakly and strongly bound states.	Lysine	53-56	myosin heavy chain 14	Homo sapiens	35-41
27462807-3	2016	RNF168 ubiquitinates H2A on lysine 13 and lysine 15 (refs 7, 8) (yielding H2AK13ub and H2AK15ub, respectively), an event that triggers the recruitment of 53BP1 (also known as TP53BP1) to chromatin flanking DSBs.	Lysine	42-48	tumor protein p53 binding protein 1	Homo sapiens	154-159
26896487-0	2016	ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.	Lysine	63-69	CD40 ligand	Mus musculus	75-81
10677220-1	2000	The Ogg1 protein of Saccharomyces cerevisiae belongs to a family of DNA glycosylases and apurinic/apyrimidinic site (AP) lyases, the signature of which is the alpha-helix-hairpin-alpha-helix-Gly/Pro-Asp (HhH-GPD) active site motif together with a conserved catalytic lysine residue, to which we refer as the HhH-GPD/K family.	Lysine	267-273	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	4-8
10677220-2	2000	In the yeast Ogg1 protein, yOgg1, the HhH-GPD/K motif spans residues 225-260 and the conserved lysine is K241.	Lysine	95-101	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	13-17
33187585-2	2020	Lysine-specific demethylase 4A (KDM4A) comprises a lysine demethylase and possesses specificity for H3K9me3 and H3K36me3, which is capable of being used in order to activate histone transcription.	Lysine	51-57	lysine demethylase 4A	Rattus norvegicus	0-30
33187585-2	2020	Lysine-specific demethylase 4A (KDM4A) comprises a lysine demethylase and possesses specificity for H3K9me3 and H3K36me3, which is capable of being used in order to activate histone transcription.	Lysine	51-57	lysine demethylase 4A	Rattus norvegicus	32-37
10677220-2	2000	In the yeast Ogg1 protein, yOgg1, the HhH-GPD/K motif spans residues 225-260 and the conserved lysine is K241.	Lysine	95-101	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	27-32
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	222-228	CD40 ligand	Mus musculus	152-158
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	243-249	CD40 ligand	Mus musculus	152-158
31981262-0	2020	Structural and functional characterization of the dominant negative P-loop lysine mutation in the dynamin superfamily protein Vps1.	Lysine	75-81	dynamin 1	Homo sapiens	98-105
26896487-3	2016	Here, we showed that CD40 ligand expression in CD8(+) cytotoxic T cells was suppressed by combined epigenetic regulations in the promoter region of the Cd40lg gene, such as the methylation of CpG dinucleotides, histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20.	Lysine	243-249	CD40 ligand	Mus musculus	152-158
10675335-5	2000	The acetylation sites lie adjacent to the E2F1 DNA-binding domain and involve lysine residues highly conserved in E2F1, 2 and 3.	Lysine	78-84	E2F transcription factor 1	Homo sapiens	42-46
10675335-5	2000	The acetylation sites lie adjacent to the E2F1 DNA-binding domain and involve lysine residues highly conserved in E2F1, 2 and 3.	Lysine	78-84	E2F transcription factor 1	Homo sapiens	114-127
27268279-5	2016	We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells.	Lysine	21-27	lysine acetyltransferase 6A	Homo sapiens	73-76
32666018-7	2020	M-PTH/PTHrP exhibited low solubility in aqueous solutions of neutral pH; however, replacement of Leu18, Phe22, and His26 with the less hydrophobic residues, Ala, Ala, and Lys, at those respective positions markedly improved solubility while maintaining bioactivity.	Lysine	171-174	parathyroid hormone-like hormone	Rattus norvegicus	6-11
32312753-2	2020	Sister chromatid cohesion is established by the protein acetyltransferase Eco1, which acetylates two conserved lysine residues on the cohesin subunit Smc3 and thereby ensures correct chromatid separation in yeast (Saccharomyces cerevisiae) and other eukaryotes.	Lysine	111-117	Eco1p	Saccharomyces cerevisiae S288C	74-78
32312753-2	2020	Sister chromatid cohesion is established by the protein acetyltransferase Eco1, which acetylates two conserved lysine residues on the cohesin subunit Smc3 and thereby ensures correct chromatid separation in yeast (Saccharomyces cerevisiae) and other eukaryotes.	Lysine	111-117	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	134-154
10758475-1	2000	Dihydrodipicolinate synthase (DHDPS; EC4.2.1.52) catalyses the first reaction of lysine biosynthesis in plants and bacteria.	Lysine	81-87	dihydrodipicolinate synthase	Escherichia coli	0-28
10758475-1	2000	Dihydrodipicolinate synthase (DHDPS; EC4.2.1.52) catalyses the first reaction of lysine biosynthesis in plants and bacteria.	Lysine	81-87	dihydrodipicolinate synthase	Escherichia coli	30-35
10758475-2	2000	Plant DHDPS enzymes are strongly inhibited by lysine (I0.5 approximately 10 microM), whereas the bacterial enzymes are less (50-fold) or insensitive to lysine inhibition.	Lysine	46-52	dihydrodipicolinate synthase	Escherichia coli	6-11
26923755-8	2016	Mutation analysis revealed a T&gt;C missense mutation at nucleotide 857 of the cDNA encoding endothelin receptor B (EDNRB) in which a proline was substituted for the highly conserved Lys-286 residue (L286P) in the fifth transmembrane (TM V) domain of this G protein-coupled receptor.	Lysine	183-186	endothelin receptor type B	Mus musculus	93-114
10758475-3	2000	We found that plant dhdps sequences expressing lysine-sensitive DHDPS enzymes are unable to complement a bacterial auxotroph, although a functional plant DHDPS enzyme is formed.	Lysine	47-53	dihydrodipicolinate synthase	Escherichia coli	64-69
10758475-3	2000	We found that plant dhdps sequences expressing lysine-sensitive DHDPS enzymes are unable to complement a bacterial auxotroph, although a functional plant DHDPS enzyme is formed.	Lysine	47-53	dihydrodipicolinate synthase	Escherichia coli	154-159
10758475-4	2000	As a consequence of this, plant dhdps cDNA clones which have been isolated through functional complementation using the DHDPS-deficient Escherichia coli strain encode mutated DHDPS enzymes impaired in lysine inhibition.	Lysine	201-207	dihydrodipicolinate synthase	Escherichia coli	120-125
10758475-4	2000	As a consequence of this, plant dhdps cDNA clones which have been isolated through functional complementation using the DHDPS-deficient Escherichia coli strain encode mutated DHDPS enzymes impaired in lysine inhibition.	Lysine	201-207	dihydrodipicolinate synthase	Escherichia coli	175-180
32705067-7	2020	As daily total dietary Lys intake increased from 52.10 to 77.53 g, piglet ADG and daily litter gain linearly improved (P < 0.01).	Lysine	23-26	ADG	Sus scrofa	74-77
32444594-1	2020	The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear.	Lysine	4-10	CREB binding protein	Mus musculus	59-62
32444594-1	2020	The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear.	Lysine	4-10	E1A binding protein p300	Mus musculus	67-71
32444613-1	2020	LSD1/KDM1A is a widely conserved lysine-specific demethylase that removes methyl groups from methylated proteins, mainly histone H3.	Lysine	33-39	lysine (K)-specific demethylase 1a	Danio rerio	0-4
32444613-1	2020	LSD1/KDM1A is a widely conserved lysine-specific demethylase that removes methyl groups from methylated proteins, mainly histone H3.	Lysine	33-39	lysine (K)-specific demethylase 1a	Danio rerio	5-10
26923755-8	2016	Mutation analysis revealed a T&gt;C missense mutation at nucleotide 857 of the cDNA encoding endothelin receptor B (EDNRB) in which a proline was substituted for the highly conserved Lys-286 residue (L286P) in the fifth transmembrane (TM V) domain of this G protein-coupled receptor.	Lysine	183-186	endothelin receptor type B	Mus musculus	116-121
27235396-4	2016	We found that Lys-71 monomethylation (K71me) is catalyzed by KMT7, a methyltransferase that also targets lysine 51 (K51) in Tat.	Lysine	14-17	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	61-65
32407360-5	2020	Significantly lower mRNA transcript accumulation was also observed for the MyD88 gene in the neutrophils of ewes fed with lysine only (C).	Lysine	122-128	myeloid differentiation primary response protein MyD88	Ovis aries	75-80
10739384-4	2000	Bovine PCI has a putative reactive site peptide bond, Lys-Ser, that is different from the reactive site sequence (Arg-Ser) of other species" PCI.	Lysine	54-57	serpin family A member 5	Bos taurus	7-10
27235396-4	2016	We found that Lys-71 monomethylation (K71me) is catalyzed by KMT7, a methyltransferase that also targets lysine 51 (K51) in Tat.	Lysine	105-111	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	61-65
27235396-5	2016	Using mass spectrometry, in vitro enzymology, and modification-specific antibodies, we found that KMT7 monomethylates both Lys-71 and Lys-51 in Tat.	Lysine	123-126	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	98-102
27235396-5	2016	Using mass spectrometry, in vitro enzymology, and modification-specific antibodies, we found that KMT7 monomethylates both Lys-71 and Lys-51 in Tat.	Lysine	134-137	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	98-102
27092849-6	2016	In the paralogues OR1A1 and OR1A2, the aldehydes tend to interact in the top region of the binding pocket and close to a positively charged lysine.	Lysine	140-146	olfactory receptor family 1 subfamily A member 2	Homo sapiens	28-33
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Lysine	158-164	low density lipoprotein receptor	Homo sapiens	71-109
32223380-0	2020	Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.	Lysine	61-67	klotho	Mus musculus	25-27
32223380-0	2020	Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.	Lysine	61-67	klotho	Mus musculus	29-35
32223380-3	2020	The purpose of this study is to investigate the potential role of H3K27me3 (histone 3 lysine [K] 27 trimethylation) in the regulation of KL gene expression and examine the related molecular pathways that may drive kidney cell aging.	Lysine	86-92	klotho	Mus musculus	137-139
32223380-6	2020	Elevation of H3K27me3 levels was likely due to downregulation of the H3K27 (histone H3 Lys 27)-specific demethylase JMJD3 (the Jumonji domain containing-3) in the aged kidneys.	Lysine	87-90	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	116-121
32223380-6	2020	Elevation of H3K27me3 levels was likely due to downregulation of the H3K27 (histone H3 Lys 27)-specific demethylase JMJD3 (the Jumonji domain containing-3) in the aged kidneys.	Lysine	87-90	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	127-154
10639132-3	2000	Here we demonstrate the nucleotide-dependent binding between the lysine-rich, highly positively charged loop 12 of the KIF1A motor domain (K-loop) and the glutamate-rich, highly negatively charged C-terminal region of tubulin (E-hook).	Lysine	65-71	kinesin family member 1A	Homo sapiens	119-124
32354028-1	2020	Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1 histone demethylases that promote gene expression.	Lysine	0-6	malic enzyme 1	Homo sapiens	76-79
27373831-4	2016	Chronic activity deprivation increased the amount of neuronal dimethylated H3 at lysine 9 (H3K9me2), the catalytic product of EHMT1 and an epigenetic marker for gene repression.	Lysine	81-87	euchromatic histone lysine methyltransferase 1	Homo sapiens	126-131
32354117-6	2020	USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival.	Lysine	127-133	ubiquitin specific peptidase 20	Homo sapiens	0-5
32354117-6	2020	USP20 specifically binds to p62 and acts as a positive regulator for NF-kappaB activation by TNFalpha through deubiquitinating lysine 48 (K48)-linked polyubiquitination, eventually contributing to cell survival.	Lysine	127-133	sequestosome 1	Homo sapiens	28-31
10585398-1	1999	The adipocyte fatty acid-binding protein (AFABP) is believed to transfer unesterified fatty acids (FA) to phospholipid membranes via a collisional mechanism that involves ionic interactions between lysine residues on the protein surface and phospholipid headgroups.	Lysine	198-204	fatty acid binding protein 4	Homo sapiens	42-47
27426629-1	2016	The trimethylation of histone H3 on lysine 9 (H3K9me3) - a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) - has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in mammals.	Lysine	36-42	chromobox 5	Homo sapiens	78-81
10579719-6	1999	We have identified four major SUMO attachment-site lysine residues in Cdc3, one in Cdc11, and two in Shs1, all within the consensus sequence (IVL)KX(ED).	Lysine	51-57	septin SHS1	Saccharomyces cerevisiae S288C	101-105
10625453-6	1999	In addition, a unique lysine residue on the Cdc42-binding domain of ACK-2 (GBD-ACK) was covalently modified with a fluorescent succinimidyl ester.	Lysine	22-28	tyrosine kinase non receptor 2	Homo sapiens	68-71
32357443-1	2020	CREB-binding protein (p300/CBP) is a universal transcriptional co-regulator with lysine acetyltransferase activity.	Lysine	81-87	nejire	Drosophila melanogaster	22-26
32324495-3	2020	The BETs (bromodomain and extraterminal-containing protein family), which includes BRD2, BRD3, and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetylated lysine residues on histone tails where they facilitate the assembly of transcription complexes including transcription factors and transcriptional machinery like RNA Polymerase II.	Lysine	200-206	bromodomain containing 2	Homo sapiens	83-87
32324495-3	2020	The BETs (bromodomain and extraterminal-containing protein family), which includes BRD2, BRD3, and BRD4 and the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetylated lysine residues on histone tails where they facilitate the assembly of transcription complexes including transcription factors and transcriptional machinery like RNA Polymerase II.	Lysine	200-206	bromodomain containing 3	Homo sapiens	89-93
10625453-6	1999	In addition, a unique lysine residue on the Cdc42-binding domain of ACK-2 (GBD-ACK) was covalently modified with a fluorescent succinimidyl ester.	Lysine	22-28	tyrosine kinase non receptor 2	Homo sapiens	79-82
10625453-7	1999	The distances separating this reactive lysine from the nucleotide binding site and lysine 150 of Cdc42 were determined by fluorescence resonance energy transfer and yielded a picture for Cdc42/GBD-ACK interactions that is consistent with recent NMR structural determinations for Cdc42/effector complexes.	Lysine	39-45	tyrosine kinase non receptor 2	Homo sapiens	197-200
27426629-1	2016	The trimethylation of histone H3 on lysine 9 (H3K9me3) - a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) - has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in mammals.	Lysine	36-42	chromobox 5	Homo sapiens	204-207
10625453-7	1999	The distances separating this reactive lysine from the nucleotide binding site and lysine 150 of Cdc42 were determined by fluorescence resonance energy transfer and yielded a picture for Cdc42/GBD-ACK interactions that is consistent with recent NMR structural determinations for Cdc42/effector complexes.	Lysine	83-89	tyrosine kinase non receptor 2	Homo sapiens	197-200
32685344-2	2020	The most prevalent form of PDE is due to an underlying genetic defect in ALDH7A1 encoding Antiquitin (ATQ), an enzyme with alpha-aminoadipic semialdehyde dehydrogenase (AASADH) activity which facilitates cerebral lysine degradation.	Lysine	213-219	aldehyde dehydrogenase 7 family member A1	Homo sapiens	73-80
10625453-8	1999	The changes in reporter group fluorescence at the reactive lysine of GBD-ACK, which were induced by the binding of activated Cdc42, were also examined.	Lysine	59-65	tyrosine kinase non receptor 2	Homo sapiens	73-76
27107943-8	2016	Further analysis revealed that WWP1 ubiquitinated mHtt at an atypical position of Lys-63, which may have inhibited degradation of mutant Htt through the ubiquitin-proteasome pathway.	Lysine	82-85	huntingtin	Mus musculus	51-54
10620048-1	1999	Eukaryotic initiation factor eIF5A is essential for cell viability and contains a characteristic post-translational modification of a specific lysine residue into a hypusine.	Lysine	143-149	eukaryotic translation elongation factor 5	Drosophila melanogaster	29-34
32685344-2	2020	The most prevalent form of PDE is due to an underlying genetic defect in ALDH7A1 encoding Antiquitin (ATQ), an enzyme with alpha-aminoadipic semialdehyde dehydrogenase (AASADH) activity which facilitates cerebral lysine degradation.	Lysine	213-219	aldehyde dehydrogenase 7 family member A1	Homo sapiens	123-167
26640146-5	2016	ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27.	Lysine	188-194	ASXL transcriptional regulator 2	Homo sapiens	0-5
32308622-7	2020	Most recently, increased histone lysine crotonylation (Kcr) was observed during experimental AKI and could be reproduced in cultured tubular cells exposed to inflammatory stress triggered by the cytokine TWEAK.	Lysine	33-39	TNF superfamily member 12	Homo sapiens	204-209
10537045-3	1999	Further, the Gln and Lys residues in tau that are modified by tTG in vitro are located primarily within or adjacent to the microtubule-binding domains.	Lysine	21-24	microtubule associated protein tau	Homo sapiens	37-40
26640146-5	2016	ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27.	Lysine	188-194	lysine methyltransferase 2D	Homo sapiens	81-85
10493908-8	1999	In contrast, the peptides with a position 2 (P2) lysine mutation, IGF-I(66-75)Lys(70) and IGF-II(63-72)Lys(67), were cleaved more efficiently by PC1 and furin compared with rPC4A.	Lysine	49-55	proprotein convertase subtilisin/kexin type 1	Homo sapiens	145-148
10493908-8	1999	In contrast, the peptides with a position 2 (P2) lysine mutation, IGF-I(66-75)Lys(70) and IGF-II(63-72)Lys(67), were cleaved more efficiently by PC1 and furin compared with rPC4A.	Lysine	103-106	insulin like growth factor 2	Homo sapiens	90-96
26640146-5	2016	ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27.	Lysine	188-194	ASXL transcriptional regulator 2	Homo sapiens	142-147
32296178-8	2020	The interaction between tau and LRP1 is mediated by lysine residues in the microtubule-binding repeat region of tau.	Lysine	52-58	low density lipoprotein receptor-related protein 1	Mus musculus	32-36
26640146-6	2016	The preferential binding of the PHD finger of ASXL2 to the dimethylated H3 lysine 4 may account for its requirement for ERalpha activation.	Lysine	75-81	ASXL transcriptional regulator 2	Homo sapiens	46-51
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	dual specificity phosphatase 6	Mus musculus	40-45
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	phosphatase and tensin homolog	Homo sapiens	39-43
32183361-11	2020	YARS2 encodes the mitochondrial tyrosyl-tRNA synthetase 2 and the predicted amino acid change replaces a negatively charged and evolutionary conserved glutamate at the surface of the tRNA binding domain of YARS2 with a positively charged lysine.	Lysine	238-244	tyrosyl-tRNA synthetase 2	Canis lupus familiaris	0-5
32183361-11	2020	YARS2 encodes the mitochondrial tyrosyl-tRNA synthetase 2 and the predicted amino acid change replaces a negatively charged and evolutionary conserved glutamate at the surface of the tRNA binding domain of YARS2 with a positively charged lysine.	Lysine	238-244	tyrosyl-tRNA synthetase 2	Canis lupus familiaris	206-211
10547156-7	1999	Poly-L-lysine, but not poly-L-glutamic acid dose-dependently increased the urinary excretion of IL-1alpha.	Lysine	0-13	interleukin 1 alpha	Homo sapiens	96-105
10501225-1	1999	In alpha1, beta2, and gamma2 subunits of the gamma-aminobutyric acid A (GABA(A)) receptor, a conserved lysine residue occupies the position in the middle of the predicted extracellular loop between the transmembrane M2 and M3 regions.	Lysine	103-109	adrenoceptor alpha 1D	Homo sapiens	3-9
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	82-89
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	phosphatase and tensin homolog	Homo sapiens	143-147
10491308-2	1999	The guanine base can form two specific hydrogen bonds with the active site residues Ser(121) and Val(73) and the attached negatively charged phosphate groups can entertain stabilizing electrostatic interactions with two clusters of positively charged patches on the PAP surface formed by Lys(210) and Arg(179) from one side and Arg(122) and Arg(135) from the other side of the active site.	Lysine	288-291	regenerating family member 3 alpha	Homo sapiens	266-269
32109368-6	2020	Interestingly, the addition of charged and hydrophilic amino acids, such as glutamate or lysine stabilizes KLF4, enhancing reprogramming phenotypes.	Lysine	89-95	Kruppel like factor 4	Homo sapiens	107-111
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	158-165
27295432-5	2016	The mapping of ubiquitylation sites in PTEN by mass spectrometry showed that both NEDD4-1 and WWP2 can target a broad range of Lys residues in PTEN, although NEDD4-1 versus WWP2 showed a stronger preference for ubiquitylating PTEN"s C2 domain.	Lysine	127-130	phosphatase and tensin homolog	Homo sapiens	143-147
32182705-4	2020	The matrix effects were linked to lysine 794 (K794) in the beta1 integrin cytoplasmic domain based on studies of cells expressing acetylated (K794Q) and non-acetylated (K794R) mimetics.	Lysine	34-40	integrin subunit beta 1	Homo sapiens	59-73
27295432-8	2016	These studies reveal how the PTEN E3 ligases WWP2 and NEDD4-1 exhibit distinctive properties in Lys selectivity and sensitivity to PTEN phosphorylation.	Lysine	96-99	phosphatase and tensin homolog	Homo sapiens	29-33
32129764-4	2020	We demonstrate that USP16 constitutes a component of late cytoplasmic pre-40S subunits that promotes the removal of ubiquitin from an internal lysine of ribosomal protein RPS27a/eS31.	Lysine	143-149	carboxylesterase 3	Homo sapiens	178-182
10458765-6	1999	Testing of a mutant DQ2 molecule demonstrated that the Lys residue at beta71 of DQ2 is important for binding of the deamidated peptide.	Lysine	55-58	torsin family 1 member A	Homo sapiens	20-23
27295432-8	2016	These studies reveal how the PTEN E3 ligases WWP2 and NEDD4-1 exhibit distinctive properties in Lys selectivity and sensitivity to PTEN phosphorylation.	Lysine	96-99	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	54-61
10458765-6	1999	Testing of a mutant DQ2 molecule demonstrated that the Lys residue at beta71 of DQ2 is important for binding of the deamidated peptide.	Lysine	55-58	torsin family 1 member A	Homo sapiens	80-83
27197174-5	2016	Enabled by a shotgun mass spectrometry analysis founded on tissue culture models, we identified a candidate SIRT2 deacetylation target at PKM2 lysine 305 (K305).	Lysine	143-149	sirtuin 2	Mus musculus	108-113
10329657-2	1999	Using alanine scanning mutagenesis, the role in receptor activation of charged amino acids (Asp, Glu, Lys, and Arg) and cysteines in the extracellular loops (EL) of the human P2Y1 receptor has been investigated.	Lysine	102-105	purinergic receptor P2Y1	Homo sapiens	175-188
31726157-0	2020	Fabrication and application of an amperometric lysine biosensor based on covalently immobilized lysine oxidase nanoparticles onto Au electrode.	Lysine	47-53	lysyl oxidase	Homo sapiens	96-110
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Lysine	20-26	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	107-112
31987637-4	2020	Diagnostic whole-exome sequencing revealed a hemizygote missense mutation c.278 T > A in exon 2 of the GJB1 gene, with lysine at position 93 of the mature protein (p.M93K).	Lysine	119-125	gap junction protein beta 1	Homo sapiens	103-107
32231406-9	2020	Furthermore, the level of histone H3 tri-methylation at lysine 27 was decreased, and a pre-treatment with a H3K27 demethylase inhibitor notably suppressed lysyl oxidase expression in M2-like macrophages.	Lysine	56-62	lysyl oxidase	Homo sapiens	155-168
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	164-170	interferon alpha inducible protein 27	Homo sapiens	4-7
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	164-170	cyclin dependent kinase inhibitor 1B	Homo sapiens	8-12
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	164-170	interferon alpha inducible protein 27	Homo sapiens	104-107
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	164-170	cyclin dependent kinase inhibitor 1B	Homo sapiens	108-112
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	260-266	interferon alpha inducible protein 27	Homo sapiens	4-7
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	260-266	cyclin dependent kinase inhibitor 1B	Homo sapiens	8-12
32296036-7	2020	Finally, we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.	Lysine	91-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-48
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Lysine	65-71	carbonic anhydrase 1	Rattus norvegicus	128-132
32120841-0	2020	Isoform-Specific Lysine Methylation of RORalpha2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression.	Lysine	17-23	lysine acetyltransferase 5	Homo sapiens	93-98
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	260-266	interferon alpha inducible protein 27	Homo sapiens	104-107
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Lysine	260-266	cyclin dependent kinase inhibitor 1B	Homo sapiens	108-112
27403640-4	2016	Two cDNAs from the model plant organism Arabidopsis thaliana that are involved in the metabolism of lysine (L,L-diaminopimelate aminotransferase (dapL) and tyrosine aminotransferase (tyrB) involved in the metabolism of tyrosine and phenylalanine are highlighted.	Lysine	100-106	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	108-144
10212234-7	1999	The lysine residue of the Sp100 protein, to which SUMO-1 is covalently linked, was mapped within and may therefore modulate the previously described HP1 protein-binding site.	Lysine	4-10	SP100 nuclear antigen	Homo sapiens	26-31
31927997-3	2020	Herein, anionic glutamate residue-based scanning was applied to the hydrophobic surface of a self-assembling lysine-rich cationic amphipathic peptide (CAP) KL1.	Lysine	109-115	KIT ligand	Homo sapiens	156-159
31759822-3	2020	Upon serum deprivation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox Protein (ADNP) and located near cell-cycle genes recruits TFIIIC, which alters their chromatin accessibility by direct acetylation of histone H3 lysine-18 (H3K18).	Lysine	246-252	general transcription factor IIIC subunit 1	Homo sapiens	159-165
27403640-4	2016	Two cDNAs from the model plant organism Arabidopsis thaliana that are involved in the metabolism of lysine (L,L-diaminopimelate aminotransferase (dapL) and tyrosine aminotransferase (tyrB) involved in the metabolism of tyrosine and phenylalanine are highlighted.	Lysine	100-106	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	146-150
27315556-5	2016	Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impairs the interaction with the mRNA decay factors DCP2, EDC4, and XRN1, but not EDC3, thus remodeling P-body architecture.	Lysine	27-34	5'-3' exoribonuclease 1	Homo sapiens	146-150
32028644-4	2020	Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) is a histone methyltransferase and catalyzes mono- and di-methylation at histone H3 lysine 9 (H3K9me1 and H3K9me2, respectively), leading to gene silencing.	Lysine	20-26	euchromatic histone lysine methyltransferase 2	Homo sapiens	50-55
10209031-2	1999	Recently, mutation of glycine 2, cysteine 3, and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs, prompting the designation of these residues as an ITAM recognition motif (Gauen, L.K.T., M.E.	Lysine	49-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
10209031-2	1999	Recently, mutation of glycine 2, cysteine 3, and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs, prompting the designation of these residues as an ITAM recognition motif (Gauen, L.K.T., M.E.	Lysine	49-56	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	102-105
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	lipoprotein lipase	Homo sapiens	283-286
10092646-4	1999	CDKs have been shown to have a high preference for a basic residue (lysine or arginine) as the n+3 residue, n being the location in the primary sequence of a phosphoacceptor serine or threonine.	Lysine	68-74	cyclin dependent kinase 5	Homo sapiens	0-4
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Lysine	30-33	SCT	Canis lupus familiaris	17-25
31576005-1	2020	BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair.	Lysine	46-52	BRCA1 DNA repair associated	Homo sapiens	0-5
31576005-1	2020	BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair.	Lysine	46-52	BRCA2 DNA repair associated	Homo sapiens	6-11
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Lysine	30-33	SCT	Canis lupus familiaris	147-155
31576005-1	2020	BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair.	Lysine	46-52	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	34-39
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Lysine	30-33	SCT	Canis lupus familiaris	147-155
26988343-6	2016	Thus, our study, together with previous findings, supported that the posttranslational modifications of NLS of poleta played a dual role in polymerase switching, where Lys(682) deubiquitination promotes the recruitment of poleta to PCNA immediately prior to lesion bypass and Ser(687) phosphorylation stimulates its departure from the replication fork immediately after lesion bypass.	Lysine	168-171	proliferating cell nuclear antigen	Homo sapiens	232-236
31478652-6	2020	In this paper, we annotate ABHD14B as a lysine deacetylase (KDAC), showing this enzyme"s ability to transfer an acetyl group from a post-translationally acetylated lysine to coenzyme A (CoA), to yield acetyl-CoA, while regenerating the free amine of protein lysine residues.	Lysine	40-46	abhydrolase domain containing 14B	Homo sapiens	27-34
31478652-6	2020	In this paper, we annotate ABHD14B as a lysine deacetylase (KDAC), showing this enzyme"s ability to transfer an acetyl group from a post-translationally acetylated lysine to coenzyme A (CoA), to yield acetyl-CoA, while regenerating the free amine of protein lysine residues.	Lysine	164-170	abhydrolase domain containing 14B	Homo sapiens	27-34
31755685-2	2020	Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodomain (ChD).	Lysine	157-163	chromobox 2	Homo sapiens	39-43
31755685-2	2020	Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6, CBX7, and CBX8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodomain (ChD).	Lysine	157-163	chromobox 6	Homo sapiens	51-55
10198285-7	1999	The amount of P-cadherin transcript was 2- to 4-fold higher in cells plated on the function-blocking anti-integrin antibodies and on the extracellular matrix proteins, as compared to cells plated on poly-L-lysine, whereas the K14 transcript levels were not significantly modified in response to adhesion.	Lysine	199-212	cadherin 3	Mus musculus	14-24
27209302-5	2016	Using mass spectrometry analysis, we firstly confirmed acetylation as a previously unreported modification of TFEB and found that SIRT1 directly interacted with and deacetylated TFEB at lysine residue 116.	Lysine	186-192	sirtuin 1	Mus musculus	130-135
10080889-6	1999	Side-chain modifications and proteolysis demonstrated that Lys and Arg residues in the C-terminal region of alpha1LG4 are essential for heparin binding.	Lysine	59-62	adrenoceptor alpha 1D	Homo sapiens	108-117
33389883-8	2020	Tregs uniquely constitutively express an E3 ligase known as the gene related to anergy in lymphocytes (GRAIL), which ubiquinates the exact lysine on the Cul5 protein that needs to be neddylated as a condition for the activation and consequent ubiquitination of pJAKl.	Lysine	139-145	ring finger protein 128	Homo sapiens	103-108
27211601-5	2016	PolySUMO5 conjugation of PML at lysine 160 facilitates recruitment of PML-NB components, which enlarges PML-NBs.	Lysine	32-38	PML nuclear body scaffold	Homo sapiens	25-28
31939625-0	2020	Histone 3 lysine 9 acetylation of BRG1 in the medial prefrontal cortex is associated with heroin self-administration in rats.	Lysine	10-16	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	34-38
31939625-4	2020	However, little is known about the relationship between histone H3 lysine 9 acetylation (H3K9ac) and BRG1 in response to heroin.	Lysine	67-73	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	101-105
31939625-5	2020	The present study aimed to assess the contribution of histone 3 lysine 9 acetylation of BRG1 to heroin self-administration.	Lysine	64-70	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	88-92
10022878-5	1999	Stable tetramer formation of Stat5 is mediated through protein-protein interactions involving a tryptophan residue conserved in all STATs and a lysine residue in the Stat5 N-terminal domain (N domain).	Lysine	144-150	signal transducer and activator of transcription 5A	Homo sapiens	29-34
10051546-0	1999	Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.	Lysine	20-26	cannabinoid receptor 2	Homo sapiens	75-78
27211601-5	2016	PolySUMO5 conjugation of PML at lysine 160 facilitates recruitment of PML-NB components, which enlarges PML-NBs.	Lysine	32-38	PML nuclear body scaffold	Homo sapiens	70-73
10051546-3	1999	A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function.	Lysine	2-8	cannabinoid receptor 2	Homo sapiens	58-61
10051546-3	1999	A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function.	Lysine	2-8	cannabinoid receptor 2	Homo sapiens	118-121
27211601-5	2016	PolySUMO5 conjugation of PML at lysine 160 facilitates recruitment of PML-NB components, which enlarges PML-NBs.	Lysine	32-38	PML nuclear body scaffold	Homo sapiens	70-73
26915459-5	2016	Upon viral infection, TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.	Lysine	39-42	TANK binding kinase 1	Homo sapiens	124-128
9952163-10	1999	gas-1(fc21) is a missense mutation replacing a strictly conserved arginine with lysine.	Lysine	80-86	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	0-5
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	21-27	lysine (K)-specific demethylase 3A	Mus musculus	44-49
31629659-3	2019	We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.	Lysine	103-109	lysine (K)-specific demethylase 3A	Mus musculus	44-49
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Lysine	21-27	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	62-67
27035422-2	2016	Combination of 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomolar domain.	Lysine	62-65	crystallin, gamma B	Mus musculus	21-24
31679457-6	2019	Here, we describe an arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2 in HEK293 cells.	Lysine	30-36	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	149-154
10195455-12	1999	Analogs of a bioadhesive fragment from the laminin alpha1 chain were prepared by replacing the essential Lys with Dpm(NH2) (20) and Dpm(Leu)(NH2) (21).	Lysine	105-108	laminin subunit alpha 1	Homo sapiens	43-57
26929412-7	2016	Our results clearly revealed structural determinants for the substrate preference of SMYD3 and provided mechanistic insights into lysine methylation of MAP3K2.	Lysine	130-136	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	152-158
9890932-0	1999	Effect of pH on formation of a nativelike intermediate on the unfolding pathway of a Lys 73 --&gt; His variant of yeast iso-1-cytochrome c. Previous work on a Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c at pH 7.5 [Godbole et al.	Lysine	85-88	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	120-125
9890932-0	1999	Effect of pH on formation of a nativelike intermediate on the unfolding pathway of a Lys 73 --&gt; His variant of yeast iso-1-cytochrome c. Previous work on a Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c at pH 7.5 [Godbole et al.	Lysine	159-162	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	120-125
9890932-0	1999	Effect of pH on formation of a nativelike intermediate on the unfolding pathway of a Lys 73 --&gt; His variant of yeast iso-1-cytochrome c. Previous work on a Lys 73 --&gt; His (H73) variant of iso-1-cytochrome c at pH 7.5 [Godbole et al.	Lysine	159-162	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	194-199
31494535-2	2019	The lysine specific demethylase enzyme LSD1 regulates the function of histone proteins in cells through the demethylation of specific lysine amino acid residues.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	39-43
31515273-3	2019	Circadian acetylation of Lys-537 within the G-region enhances repressive BMAL1-TAD-CRY1 interactions.	Lysine	25-28	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	73-78
31515273-4	2019	Here, we characterized the interaction of the CBP-KIX domain with BMAL1 proteins including the BMAL1-TAD, parts of the G-region, and Lys-537.	Lysine	133-136	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	66-71
31515273-9	2019	The BMAL1(K537Q) mutation mimicking Lys-537 acetylation, however, did not affect the KIX-binding affinity, in contrast to its enhancing effect on CRY1 binding.	Lysine	36-39	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	4-9
26988033-4	2016	Here, we identified ubiquitin-specific protease 19 (USP19) as a positive regulator of autophagy, but a negative regulator of type I interferon (IFN) signaling.USP19 stabilizes Beclin-1 by removing the K11-linked ubiquitin chains of Beclin-1 at lysine 437.	Lysine	244-250	beclin 1	Saccharomyces cerevisiae S288C	176-184
31374292-4	2019	We found that histone H3 lysine 4 (H3K4) demethylase RBP2 expression is negatively correlated with BCR-ABL expression, which suggests a regulatory link between these two genes.	Lysine	25-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	99-106
26496208-6	2016	STAT1 regulates the transcriptional activity of OGG1 through recruiting and binding to the gamma-interferon activation site (GAS) motif of the OGG1 promoter region, and chromatin remodeling by acetylation and dimethylation of lysine-14 and -4 residues of histone H3.	Lysine	226-232	8-oxoguanine DNA glycosylase	Homo sapiens	48-52
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	kinase insert domain receptor	Homo sapiens	160-165
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	activin A receptor type 1	Homo sapiens	197-202
31665637-4	2019	The 1-pyrin region of IFI16 is responsible for the IFI16-STING interaction, and the first three lysines in the N-terminal region of IFI16 are the key sites that lead to STING-mediated IFI16 ubiquitination and degradation.	Lysine	96-103	interferon gamma inducible protein 16	Homo sapiens	22-27
31665637-4	2019	The 1-pyrin region of IFI16 is responsible for the IFI16-STING interaction, and the first three lysines in the N-terminal region of IFI16 are the key sites that lead to STING-mediated IFI16 ubiquitination and degradation.	Lysine	96-103	interferon gamma inducible protein 16	Homo sapiens	51-56
31665637-4	2019	The 1-pyrin region of IFI16 is responsible for the IFI16-STING interaction, and the first three lysines in the N-terminal region of IFI16 are the key sites that lead to STING-mediated IFI16 ubiquitination and degradation.	Lysine	96-103	interferon gamma inducible protein 16	Homo sapiens	51-56
31665637-4	2019	The 1-pyrin region of IFI16 is responsible for the IFI16-STING interaction, and the first three lysines in the N-terminal region of IFI16 are the key sites that lead to STING-mediated IFI16 ubiquitination and degradation.	Lysine	96-103	interferon gamma inducible protein 16	Homo sapiens	51-56
9915770-5	1999	The covalent complexes are likely a result of isopeptide bond formation between lysine 193 of TnI and glutamine 191 of TnT by the cross-linking enzyme transglutaminase.	Lysine	80-86	troponin I3, cardiac type	Rattus norvegicus	94-97
10089404-5	1999	Lysine in CPTI-II binds deeper in the specificity pocket of bovine trypsin than lysine in other known lysine-bovine-trypsin complexes, and anionic salmon trypsin lacks some of the secondary binding interactions found in the complexes formed between squash inhibitors and bovine trypsin.	Lysine	0-6	carnitine palmitoyltransferase 1B	Bos taurus	10-14
10089404-5	1999	Lysine in CPTI-II binds deeper in the specificity pocket of bovine trypsin than lysine in other known lysine-bovine-trypsin complexes, and anionic salmon trypsin lacks some of the secondary binding interactions found in the complexes formed between squash inhibitors and bovine trypsin.	Lysine	80-86	carnitine palmitoyltransferase 1B	Bos taurus	10-14
10089404-5	1999	Lysine in CPTI-II binds deeper in the specificity pocket of bovine trypsin than lysine in other known lysine-bovine-trypsin complexes, and anionic salmon trypsin lacks some of the secondary binding interactions found in the complexes formed between squash inhibitors and bovine trypsin.	Lysine	102-108	carnitine palmitoyltransferase 1B	Bos taurus	10-14
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	268-271	deleted in lymphocytic leukemia 1	Homo sapiens	70-75
9857182-5	1998	The ability of the RV glycoprotein to bind p75NTR was dependent on the presence of a lysine and arginine in positions 330 and 333 respectively of antigenic site III, which is known to control virus penetration into motor and sensory neurons of adult mice.	Lysine	85-91	nerve growth factor receptor	Homo sapiens	43-49
31481451-0	2019	The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.	Lysine	19-25	G3BP stress granule assembly factor 1	Homo sapiens	33-38
31481451-5	2019	We found that the lysine 376 residue (K376) of G3BP1, which is in the RRM RNA binding domain, was acetylated.	Lysine	18-24	G3BP stress granule assembly factor 1	Homo sapiens	47-52
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	deleted in lymphocytic leukemia 1	Homo sapiens	70-75
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	deleted in lymphocytic leukemia 1	Homo sapiens	70-75
31628376-6	2019	The N-terminal RING-finger domain of LNX1/2 ubiquitinates a cytoplasmic C-terminal lysine cluster in GlyT2 (K751, K773, K787 and K791), and this process regulates the expression levels and transport activity of GlyT2.	Lysine	83-89	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	101-106
31628376-6	2019	The N-terminal RING-finger domain of LNX1/2 ubiquitinates a cytoplasmic C-terminal lysine cluster in GlyT2 (K751, K773, K787 and K791), and this process regulates the expression levels and transport activity of GlyT2.	Lysine	83-89	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	211-216
26878866-7	2016	Mass spectrometry analyses revealed that theN-terminal amino group of Leu-1 was highly reactive and was modified almost instantly by cyanate to generate the predominant form of the modified peptide, named LL-37(C1) This was followed by the sequential carbamylation of Lys-8, Lys-12, and Lys-15 to yield LL-37(C8), and Lys-15 to yield LL-37(C12,15) Carbamylation had profound and diverse effects on the structure and biological properties of LL-37.	Lysine	275-278	deleted in lymphocytic leukemia 1	Homo sapiens	70-75
27010793-5	2016	Repression of the PU.1 gene involves both DNA methylation at the URE and its histone H3 lysine-K9 methylation and deacetylation as well as the H3K27 methylation at additional DNA elements and the promoter.	Lysine	88-94	Spi-1 proto-oncogene	Homo sapiens	18-22
31404772-8	2019	L-Lysine treatment significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor alpha, interleukin-8, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts.	Lysine	0-8	myeloperoxidase	Mus musculus	216-219
9819417-4	1998	We found that expression of E3 in yeast overcomes the lethal effect of PKR in a manner requiring key residues (Lys-167 and Arg-168) needed for dsRNA binding by E3 in vitro.	Lysine	111-114	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
9819417-9	1998	In yeast two-hybrid assays and in vitro protein binding experiments, segments of E3 and PKR containing their respective DRBMs interacted in a manner requiring E3 residues Lys-167 and Arg-168.	Lysine	171-174	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	88-91
9817840-6	1998	The overall N domain structure in the context of the NK1 fragment is similar to the structure of the isolated domain; two lysines and an arginine residue coordinate a bound sulfate ion.	Lysine	122-129	tachykinin receptor 1	Homo sapiens	53-56
31527837-5	2019	KAT2A selectively acetylates H2A.Z.1 versus H2A.Z.2 in vitro on several well-defined lysines and we unveiled that alanine-14 in H2A.Z.2 is responsible for inhibiting the activity of KAT2A.	Lysine	85-92	lysine acetyltransferase 2A	Homo sapiens	0-5
9817840-7	1998	The NK1 kringle domain is homologous to kringle 4 from plasminogen, except that the lysine-binding pocket is altered by the insertion of a glycine residue.	Lysine	84-90	tachykinin receptor 1	Homo sapiens	4-7
26895889-3	2016	Here we show that these clustered pathways are characterized by distinct chromatin signatures of histone 3 lysine trimethylation (H3K27me3) and histone 2 variant H2A.Z, associated with cluster repression and activation, respectively, and represent discrete windows of co-regulation in the genome.	Lysine	107-113	H2A.Z variant histone 1	Homo sapiens	162-167
9817840-11	1998	CONCLUSIONS: A cluster of exposed lysine and arginine residues in or near the hairpin-loop region of the N domain might form part of the NK1 heparin-binding site.	Lysine	34-40	tachykinin receptor 1	Homo sapiens	137-140
31400111-4	2019	SET8 methylates UHRF1 at lysine 385 and this modification leads to ubiquitination and degradation of UHRF1.	Lysine	25-31	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	16-21
26914285-4	2016	ThioAcK and AcK were site-specifically incorporated at different lysine positions into human histone H3, either individually or in pairs.	Lysine	65-71	tyrosine kinase non receptor 2	Homo sapiens	4-7
31433161-2	2019	Recently, it has been shown that K-Ras4a, R-Ras2, and Rac1 are regulated by lysine fatty acylation.	Lysine	76-82	KRAS proto-oncogene, GTPase	Homo sapiens	33-40
31433161-2	2019	Recently, it has been shown that K-Ras4a, R-Ras2, and Rac1 are regulated by lysine fatty acylation.	Lysine	76-82	Rac family small GTPase 1	Homo sapiens	54-58
9805122-3	1998	The analysis of the dystrophin gene showed that the three brothers had A-->C transversion at nucleotide 6092 in exon 41, a missense mutation which converts lysine into glutamine.	Lysine	156-162	dystrophin	Homo sapiens	20-30
9846894-10	1998	These findings, combined with the results on tau chemical modifications suggest that the reactive lysine residues within functional domains on tau, e.g., those of the repetitive binding motifs, were affected by these modifications.	Lysine	98-104	microtubule associated protein tau	Homo sapiens	45-48
31433161-8	2019	Lysine fatty acylated RalB exhibited enhanced plasma membrane localization and recruited its known effectors Sec5 and Exo84, members of the exocyst complex, to the plasma membrane.	Lysine	0-6	exocyst complex component 8	Homo sapiens	118-123
26755727-5	2016	Surprisingly, recent reports claim that Naa10 may also acetylate lysine residues of diverse targets, including methionine sulfoxide reductase A, myosin light chain kinase, and Runt-related transcription factor 2.	Lysine	65-71	myosin light chain kinase	Homo sapiens	145-211
31527584-2	2019	Since EED is a Polycomb-Group protein and a core component of the polycomb repressive complex 2 (PRC2), we tested the involvement of PICOT in the regulation of PRC2-mediated H3 lysine 27 trimethylation (H3K27me3), transcription and translation of selected PRC2 target genes.	Lysine	177-183	embryonic ectoderm development	Homo sapiens	6-9
9804356-6	1998	Five of the 13 had the same mutation as previously found, a G to A transversion leading to a lysine for glutamic acid substitution (E413K) in the 2B domain (residue 117 of the 2B helix) of hHb6.	Lysine	93-99	keratin 86	Homo sapiens	189-193
27011246-2	2016	FHHt results from mutations in the genes encoding WNK1 and WNK4, two serine-threonine kinases of the WNK (With No lysine [K]) family.	Lysine	114-120	WNK lysine deficient protein kinase 4	Homo sapiens	59-63
9756897-2	1998	The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, and a P6 Ile and a P4 Arg were most inhibitory against PC2.	Lysine	59-62	proprotein convertase subtilisin/kexin type 1	Homo sapiens	106-109
31102572-3	2019	This function is provided by elastin"s exceptional properties, which mainly derive from a unique covalent cross-linking between hydrophilic lysine-rich motifs of units of the monomeric precursor tropoelastin.	Lysine	140-146	elastin	Homo sapiens	29-36
31102572-3	2019	This function is provided by elastin"s exceptional properties, which mainly derive from a unique covalent cross-linking between hydrophilic lysine-rich motifs of units of the monomeric precursor tropoelastin.	Lysine	140-146	elastin	Homo sapiens	195-207
26750096-2	2016	The development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of methyl-groups to lysine residues, such as the protein lysine mono-methyltransferase SMYD2, is an active area of drug discovery.	Lysine	137-143	SET and MYND domain containing 2	Homo sapiens	204-209
31320481-4	2019	We show that the Mediator subunit MED25 physically recruits LUH to MYC2 target promoters that then links MYC2 with HAC1-dependent acetylation of Lys-9 of histone H3 (H3K9ac) to activate JAZ2 and LOX2 Moreover, LUH promotes hormone-dependent enhancement of protein interactions between MYC2 and its coactivators MED25 and HAC1.	Lysine	145-148	mediator complex subunit 25	Homo sapiens	34-39
31320481-4	2019	We show that the Mediator subunit MED25 physically recruits LUH to MYC2 target promoters that then links MYC2 with HAC1-dependent acetylation of Lys-9 of histone H3 (H3K9ac) to activate JAZ2 and LOX2 Moreover, LUH promotes hormone-dependent enhancement of protein interactions between MYC2 and its coactivators MED25 and HAC1.	Lysine	145-148	mediator complex subunit 25	Homo sapiens	311-316
31508398-2	2019	Methods: The lysine metabolites of 15 patients with molecularly confirmed PDE were detected before and 4 h after taking a single oral dose of pyridoxine, respectively, using liquid chromatography-mass spectrometry (LC-MS/MS) method.	Lysine	13-19	aldehyde dehydrogenase 7 family member A1	Homo sapiens	74-77
9809067-2	1998	We show that CBP and P/CAF acetylate HMG I(Y), the essential architectural component required for enhanceosome assembly, at distinct lysine residues, causing distinct effects on transcription.	Lysine	133-139	high mobility group AT-hook 1	Homo sapiens	37-45
9737865-10	1998	The lower number of pKa 8.9 Lys leads to a reduction in binding of small, dense, and light LDL to the cellular LDL receptor and prolongs their plasma residence time, thereby elevating the atherogenicity of these particles.	Lysine	28-31	low density lipoprotein receptor	Homo sapiens	111-123
26750096-4	2016	Here, using stable isotopic labeling with amino acids in cell culture (SILAC) coupled with immunoaffinity enrichment of mono-methyl-lysine (Kme1) peptides and mass spectrometry, we report a comprehensive, large-scale proteomic study of lysine mono-methylation, comprising a total of 1032 Kme1 sites in esophageal squamous cell carcinoma (ESCC) cells and 1861 Kme1 sites in ESCC cells overexpressing SMYD2.	Lysine	132-138	SET and MYND domain containing 2	Homo sapiens	399-404
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	68-95
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	97-101
26733201-0	2016	Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation.	Lysine	132-138	histone deacetylase 1	Mus musculus	0-28
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	107-111
31390367-6	2019	The GoMADScan search on PhosphoSitePlus databases identified methylation of conserved lysine residues in the core GTPase domain of RAS superfamily GTPases, including residues corresponding to RAS Lys-5, Lys-16, and Lys-117.	Lysine	86-92	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	196-201
9611271-10	1998	Comparison of amino acid content revealed that BmP109 contained much more cysteine and lysine but less glycine and arginine than the antiapoptotic proteins.	Lysine	87-93	saposin-related	Bombyx mori	47-53
26854234-3	2016	SIRT2 interacts with and deacetylates ATRIP at lysine 32 (K32) in response to replication stress.	Lysine	47-53	sirtuin 2	Homo sapiens	0-5
9687021-6	1998	The order for k(cat)/Km values of AAP-S at the optimal pH (pH 7.5) was Lys-&gt;Met-&gt;Arg-&gt;Ala-&gt;Leu-&gt;Phe-&gt;Tyr-&gt;Lys-Ala-MCAs.	Lysine	71-74	alanyl aminopeptidase, membrane	Rattus norvegicus	34-39
9687021-6	1998	The order for k(cat)/Km values of AAP-S at the optimal pH (pH 7.5) was Lys-&gt;Met-&gt;Arg-&gt;Ala-&gt;Leu-&gt;Phe-&gt;Tyr-&gt;Lys-Ala-MCAs.	Lysine	127-130	alanyl aminopeptidase, membrane	Rattus norvegicus	34-39
31428587-1	2019	Lysine specific demethylase 1 (LSD1) functions as a transcriptional repressor through demethylating active histone marks such as mono- or di-methylated histone 3 lysine 4 (H3K4) and interacting with histone deacetylases.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	0-29
31428587-1	2019	Lysine specific demethylase 1 (LSD1) functions as a transcriptional repressor through demethylating active histone marks such as mono- or di-methylated histone 3 lysine 4 (H3K4) and interacting with histone deacetylases.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	31-35
26842955-3	2016	Here we find that MeCP2 could be SUMO-modified by the E3 ligase PIAS1 at Lys-412.	Lysine	73-76	methyl CpG binding protein 2	Mus musculus	18-23
31211500-4	2019	Here, we detected the expression of common histone demethylation modifiers and found that the histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) demethylase KDM1A (or lysine demethylase 1A) is frequently overexpressed in PTC tissues and cell lines.	Lysine	105-111	lysine demethylase 1A	Homo sapiens	156-161
31211500-4	2019	Here, we detected the expression of common histone demethylation modifiers and found that the histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) demethylase KDM1A (or lysine demethylase 1A) is frequently overexpressed in PTC tissues and cell lines.	Lysine	105-111	lysine demethylase 1A	Homo sapiens	166-187
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Lysine	133-136	uncoupling protein 1	Homo sapiens	52-55
31211500-4	2019	Here, we detected the expression of common histone demethylation modifiers and found that the histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) demethylase KDM1A (or lysine demethylase 1A) is frequently overexpressed in PTC tissues and cell lines.	Lysine	128-134	lysine demethylase 1A	Homo sapiens	156-161
9626653-4	1998	Analysis of their LH receptor (LHR) gene revealed a homozygous missense mutation resulting in a substitution of a lysine residue for a isoleucine residue at position 625 of the receptor.	Lysine	114-120	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	18-29
26212494-5	2016	We further showed that FOXP2 is selectively SUMOylated in vivo on a phylogenetically conserved lysine 674 but the SUMOylation does not alter subcellular localization and stability of FOXP2.	Lysine	95-101	forkhead box P2	Homo sapiens	23-28
9626653-4	1998	Analysis of their LH receptor (LHR) gene revealed a homozygous missense mutation resulting in a substitution of a lysine residue for a isoleucine residue at position 625 of the receptor.	Lysine	114-120	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	31-34
9585533-15	1998	Using an in vitro binding assay, we have demonstrated that chimpanzee Lp(a) exhibits poor lysine-specific interaction with both intact and plasmin-degraded fibrin as compared to its human counterpart.	Lysine	90-96	lipoprotein(a)	Pan troglodytes	70-75
31211500-4	2019	Here, we detected the expression of common histone demethylation modifiers and found that the histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) demethylase KDM1A (or lysine demethylase 1A) is frequently overexpressed in PTC tissues and cell lines.	Lysine	128-134	lysine demethylase 1A	Homo sapiens	166-187
30448242-2	2019	The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development.	Lysine	12-18	lysine (K)-specific demethylase 5B	Mus musculus	32-37
30448242-2	2019	The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development.	Lysine	86-92	lysine (K)-specific demethylase 5B	Mus musculus	32-37
26675548-6	2016	At the molecular level, we show that upon SSBs WWOX is modified at lysine 274 by ubiquitination mediated by the ubiquitin E3 ligase ITCH and interacts with ataxia telangiectasia-mutated (ATM).	Lysine	67-73	ATM serine/threonine kinase	Homo sapiens	156-185
31141233-4	2019	The polybasic domain of K-Ras4B with its stretch of lysine residues is essential for its plasma membrane targeting and localization.	Lysine	52-58	KRAS proto-oncogene, GTPase	Homo sapiens	24-31
31141233-5	2019	Employing CD and fluorescence spectroscopy, confocal fluorescence, and atomic force microscopy we show that the molecular tweezer CLR01 is able to efficiently bind to the lysine stretch in the polybasic domain of K-Ras4B, resulting in dissociation of the K-Ras4B protein from the lipid membrane and disintegration of K-Ras4B nanoclusters in the lipid bilayer.	Lysine	171-177	KRAS proto-oncogene, GTPase	Homo sapiens	213-220
31141233-5	2019	Employing CD and fluorescence spectroscopy, confocal fluorescence, and atomic force microscopy we show that the molecular tweezer CLR01 is able to efficiently bind to the lysine stretch in the polybasic domain of K-Ras4B, resulting in dissociation of the K-Ras4B protein from the lipid membrane and disintegration of K-Ras4B nanoclusters in the lipid bilayer.	Lysine	171-177	KRAS proto-oncogene, GTPase	Homo sapiens	255-262
31141233-5	2019	Employing CD and fluorescence spectroscopy, confocal fluorescence, and atomic force microscopy we show that the molecular tweezer CLR01 is able to efficiently bind to the lysine stretch in the polybasic domain of K-Ras4B, resulting in dissociation of the K-Ras4B protein from the lipid membrane and disintegration of K-Ras4B nanoclusters in the lipid bilayer.	Lysine	171-177	KRAS proto-oncogene, GTPase	Homo sapiens	255-262
9575181-7	1998	Significantly, expression of a RICK mutant in which the lysine of the putative ATP-binding site at position 38 was replaced by a methionine functioned as an inhibitor of CD95-mediated apoptosis.	Lysine	56-62	Fas cell surface death receptor	Homo sapiens	170-174
26675548-6	2016	At the molecular level, we show that upon SSBs WWOX is modified at lysine 274 by ubiquitination mediated by the ubiquitin E3 ligase ITCH and interacts with ataxia telangiectasia-mutated (ATM).	Lysine	67-73	ATM serine/threonine kinase	Homo sapiens	187-190
26627832-5	2016	Mutation of the consensus SUMOylation site, Lys(447), obviated Hsp27-mediated F508del NBD1 SUMOylation and degradation.	Lysine	44-47	heat shock protein family B (small) member 1	Homo sapiens	63-68
9602031-2	1998	The target residues for mutagenesis were selected on the basis of the previously reported chemical cross-linking study of these two proteins, which implicated possible charge-pair interactions between Lys-41, Lys-125, Lys-162, and Lys-163 of the enzyme, and Glu-47, Glu-48, Glu-52, Glu-60, Asp-64 (group A), and heme propionate of cytochrome b5.	Lysine	201-204	cytochrome b5 type A	Homo sapiens	331-344
9602031-2	1998	The target residues for mutagenesis were selected on the basis of the previously reported chemical cross-linking study of these two proteins, which implicated possible charge-pair interactions between Lys-41, Lys-125, Lys-162, and Lys-163 of the enzyme, and Glu-47, Glu-48, Glu-52, Glu-60, Asp-64 (group A), and heme propionate of cytochrome b5.	Lysine	209-212	cytochrome b5 type A	Homo sapiens	331-344
9602031-2	1998	The target residues for mutagenesis were selected on the basis of the previously reported chemical cross-linking study of these two proteins, which implicated possible charge-pair interactions between Lys-41, Lys-125, Lys-162, and Lys-163 of the enzyme, and Glu-47, Glu-48, Glu-52, Glu-60, Asp-64 (group A), and heme propionate of cytochrome b5.	Lysine	209-212	cytochrome b5 type A	Homo sapiens	331-344
9602031-2	1998	The target residues for mutagenesis were selected on the basis of the previously reported chemical cross-linking study of these two proteins, which implicated possible charge-pair interactions between Lys-41, Lys-125, Lys-162, and Lys-163 of the enzyme, and Glu-47, Glu-48, Glu-52, Glu-60, Asp-64 (group A), and heme propionate of cytochrome b5.	Lysine	209-212	cytochrome b5 type A	Homo sapiens	331-344
9602031-3	1998	Mutant reductases that lost one of the above-listed Lys residues showed higher K(m) values for cytochrome b5 and lower kcat values than those of the wild type, suggesting that all of the examined Lys residues participate in binding with cytochrome b5 as reported previously.	Lysine	52-55	cytochrome b5 type A	Homo sapiens	95-108
9602031-3	1998	Mutant reductases that lost one of the above-listed Lys residues showed higher K(m) values for cytochrome b5 and lower kcat values than those of the wild type, suggesting that all of the examined Lys residues participate in binding with cytochrome b5 as reported previously.	Lysine	52-55	cytochrome b5 type A	Homo sapiens	237-250
31284551-4	2019	In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment.	Lysine	53-59	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	78-83
31266503-2	2019	Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues.	Lysine	183-189	bromodomain containing 2	Homo sapiens	47-51
9602031-3	1998	Mutant reductases that lost one of the above-listed Lys residues showed higher K(m) values for cytochrome b5 and lower kcat values than those of the wild type, suggesting that all of the examined Lys residues participate in binding with cytochrome b5 as reported previously.	Lysine	196-199	cytochrome b5 type A	Homo sapiens	95-108
31266503-2	2019	Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues.	Lysine	183-189	bromodomain containing 3	Homo sapiens	53-57
9602031-3	1998	Mutant reductases that lost one of the above-listed Lys residues showed higher K(m) values for cytochrome b5 and lower kcat values than those of the wild type, suggesting that all of the examined Lys residues participate in binding with cytochrome b5 as reported previously.	Lysine	196-199	cytochrome b5 type A	Homo sapiens	237-250
26709619-3	2016	Our results show that a lysine-containing part of this H2B tail that is subject to post-translational modification is engulfed by the enlarged DNA minor groove imposed by the lesion.	Lysine	24-30	H2B clustered histone 21	Homo sapiens	55-58
9537991-0	1998	Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition.	Lysine	33-36	cyclin dependent kinase 5	Homo sapiens	85-110
30655368-3	2019	Here we show that both normal and Q287* mutant GFI1B interacted most strongly with the lysine specific demethylase-1 - REST corepressor - histone deacetylase (LSD1-RCOR-HDAC) complex in megakaryoblasts.	Lysine	87-93	lysine demethylase 1A	Homo sapiens	159-163
26682510-6	2016	RESULTS: The XPD 751 variant genotype (Lys/Gln) was more frequent in CCRCC patients than in healthy individuals (OR = 2.92, 95%CI: 1.47-5.79, p= 0.001).	Lysine	39-42	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	13-16
30854739-5	2019	This transcriptional activation of TIMP-3 was associated with the decrease in the expression of both enhancers of zeste homolog 2 (EZH2) and its catalytic product trimethylation of histone H3 at lysine 27 (H3K27me3) repressive marks at the TIMP-3 promoter with an accompanying increase in histone H3K9/18 acetylation.	Lysine	195-201	TIMP metallopeptidase inhibitor 3	Homo sapiens	35-41
31067149-7	2019	Degradative sorting requires lysine residues in the juxtamembrane region of Snc1 and is mediated by the Rsp5 ubiquitin ligase and its transmembrane adapters, Ear1 and Ssh4, which localize to endosome and vacuole membranes.	Lysine	29-35	Ear1p	Saccharomyces cerevisiae S288C	158-162
31125786-9	2019	Our results suggest that SUMOylation of Csk mainly at lysine 53 negatively modulates its tumor suppressor function by reducing its binding with Cbp and consequently, inducing c-Src activation.	Lysine	54-60	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	144-147
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Lysine	71-74	guanylate cyclase 2E, pseudogene	Homo sapiens	283-286
26521044-5	2016	Mass spectrometry and mutational analyses identified that DUSP14 was Lys63-linked ubiquitinated at lysine 103 residue.	Lysine	99-105	dual specificity phosphatase 14	Homo sapiens	58-64
9466979-10	1998	Bronchial responsiveness to lysine-aspirin correlated exclusively with LTC4 synthase+ cell counts (rho = -0.63, P = 0.049, n = 10).	Lysine	28-34	leukotriene C4 synthase	Homo sapiens	71-84
30952256-6	2019	For instance, when an additional lysine residue was introduced, the HbA alphaY42K mutant eluted later in an Hb-MIP column than wildtype HbA.	Lysine	33-39	keratin 90, pseudogene	Homo sapiens	68-71
30952256-6	2019	For instance, when an additional lysine residue was introduced, the HbA alphaY42K mutant eluted later in an Hb-MIP column than wildtype HbA.	Lysine	33-39	keratin 90, pseudogene	Homo sapiens	136-139
25640751-2	2016	HOTAIR could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation of multiple downstream genes.	Lysine	103-109	HOX transcript antisense RNA	Homo sapiens	0-6
30968282-1	2019	The receptor for advanced glycation end-products (RAGE) was initially characterized and named for its ability to bind to advanced glycation end-products (AGEs) that form upon the irreversible and non-enzymatic interaction between nucleophiles, such as lysine, and carbonyl compounds, such as reducing sugars.	Lysine	252-258	advanced glycosylation end-product specific receptor	Homo sapiens	50-54
9678356-5	1998	The third SRY mutation is a single base insertion 5" to the HMG box within codon 43, converting this lysine codon to a stop codon (K43X).	Lysine	101-107	sex determining region Y	Homo sapiens	10-13
9394010-5	1998	A comparison of the kinetics of fluorescent dye transfer showed Cx32, Cx26 and Cx45 to have progressively decreasing permeabilities to LY, but increasing permeabilities to DAPI.	Lysine	135-137	gap junction protein, beta 2	Rattus norvegicus	70-74
26576547-5	2016	All four amino acids are highly conserved among the PP2A subunit family, and all change a negatively charged acidic glutamic acid (E) to a positively charged basic lysine (K) and are predicted to disrupt the PP2A subunit binding and impair the dephosphorylation capacity.	Lysine	164-170	protein phosphatase 2 phosphatase activator	Homo sapiens	52-56
9383737-3	1997	Two other free amino groups present in insulin, the first amino acid glycine on the A chain (A1) and the 29th amino acid lysine on the B chain (B29), were first protected with a t-butoxycarbonyloxy (t-Boc) group to yield NA1, B29-di-(t-Boc) insulin.	Lysine	121-127	CD79b molecule	Homo sapiens	144-147
30082770-7	2019	Lysine residues at the 150th position of SelS and the 47th and 48th positions of SelK were the target sites for ubiquitination by PPARgamma.	Lysine	0-6	selenoprotein K	Homo sapiens	81-85
30987999-7	2019	Mutation of the putative c-Jun acetylation site at lysine 273 increased transcriptional activation of c-Jun in melanoma cells and conveyed resistance to BRAF inhibition.	Lysine	51-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-30
30987999-7	2019	Mutation of the putative c-Jun acetylation site at lysine 273 increased transcriptional activation of c-Jun in melanoma cells and conveyed resistance to BRAF inhibition.	Lysine	51-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
26576547-5	2016	All four amino acids are highly conserved among the PP2A subunit family, and all change a negatively charged acidic glutamic acid (E) to a positively charged basic lysine (K) and are predicted to disrupt the PP2A subunit binding and impair the dephosphorylation capacity.	Lysine	164-170	protein phosphatase 2 phosphatase activator	Homo sapiens	208-212
9331411-8	1997	In addition, we observed that the repair-inactive but recognition-competent Cys249 mutant (Lys249--&gt;Cys) of hOgg1 can be functionally rescued by alkylation with 2-bromoethylamine, which functionally replaces the lysine residue by generating a gamma-thia-lysine.	Lysine	215-221	8-oxoguanine DNA glycosylase	Homo sapiens	111-116
26721861-3	2016	LIKE HETEROCHROMATIN PROTEIN1 (LHP1) is so far the only known plant PRC1 component that directly binds to H3K27me3, the histone modification set by PRC2, and also associates genome-wide with trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	209-215	like heterochromatin protein (LHP1)	Arabidopsis thaliana	31-35
9241232-10	1997	A consensus sequence indicates a highly conserved lysine residue, K120 of endonuclease III or K241 of Ogg1, respectively.	Lysine	50-56	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	102-106
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Lysine	34-37	serpin family C member 1	Homo sapiens	140-145
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Lysine	66-69	serpin family C member 1	Homo sapiens	140-145
30679029-6	2019	For example, Mst84B (gene CG1988), a very basic cysteine- and lysine-rich nuclear protein and was present in the transition phase from a histone-based to a protamine-based chromatin structure.	Lysine	62-68	Male-specific transcript 84B	Drosophila melanogaster	26-32
30858544-5	2019	We identified four lysine residues in hnRNP A1 that were deacetylated by SIRT1 and SIRT6, resulting in significant inhibition of glycolysis in HCC cells.	Lysine	19-25	sirtuin 1	Homo sapiens	73-78
26671102-8	2015	Furthermore, NR2B expression was markedly elevated in striatum of Gcdh(-/-) animals receiving chronic Lys overload.	Lysine	102-105	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	13-17
30894683-5	2019	We identified UBR5 as a major ubiquitin E3 ligase that induces SOX2 degradation through ubiquitinating SOX2 at lysine 115.	Lysine	111-117	SRY-box transcription factor 2	Homo sapiens	63-67
30894683-5	2019	We identified UBR5 as a major ubiquitin E3 ligase that induces SOX2 degradation through ubiquitinating SOX2 at lysine 115.	Lysine	111-117	SRY-box transcription factor 2	Homo sapiens	103-107
31000629-6	2019	Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1).	Lysine	191-194	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	224-228
31000629-6	2019	Here we used RNA chemical footprinting and binding assays to test this model and further probe the molecular basis for the requirement for two critical tRNA-interacting residues, His-152 and Lys-187, in the context of human Thg1 (hThg1).	Lysine	191-194	tRNA-histidine guanylyltransferase 1 like	Homo sapiens	230-235
9211344-4	1997	We hypothesize that uremic toxins that contain aldehyde or ketone groups potentially could form Schiff bases with lysine residues of the VDR DNA binding domain and inhibit VDR interaction with VDREs.	Lysine	114-120	vitamin D receptor	Rattus norvegicus	137-140
9211344-6	1997	In vitro glyoxylate inhibited VDR binding to the osteocalcin and osteopontin VDREs as assessed by electrophoretic mobility shift assay and the inhibition was reversed when glyoxylate was preincubated with lysine.	Lysine	205-211	vitamin D receptor	Rattus norvegicus	30-33
26671102-8	2015	Furthermore, NR2B expression was markedly elevated in striatum of Gcdh(-/-) animals receiving chronic Lys overload.	Lysine	102-105	glutaryl-Coenzyme A dehydrogenase	Mus musculus	66-70
31135381-3	2019	Here, we report that calcineurin A (CNA), encoded by PPP3CB or PPP3CC, is constitutively ubiquitinated on lysine 327, and this polyubiquitin chain is rapidly removed by ubiquitin carboxyl-terminal hydrolase 16 (USP16) in response to intracellular calcium stimulation.	Lysine	106-112	protein phosphatase 3, catalytic subunit, alpha isoform	Mus musculus	21-34
26250114-6	2015	In addition, AcK incorporation into two target proteins (Escherichia coli malate dehydrogenase and human histone H3) caused homogenous acetylation at multiple lysine residues in high yield.	Lysine	159-165	tyrosine kinase non receptor 2	Homo sapiens	13-16
31135381-3	2019	Here, we report that calcineurin A (CNA), encoded by PPP3CB or PPP3CC, is constitutively ubiquitinated on lysine 327, and this polyubiquitin chain is rapidly removed by ubiquitin carboxyl-terminal hydrolase 16 (USP16) in response to intracellular calcium stimulation.	Lysine	106-112	protein phosphatase 3, catalytic subunit, alpha isoform	Mus musculus	36-39
31135381-3	2019	Here, we report that calcineurin A (CNA), encoded by PPP3CB or PPP3CC, is constitutively ubiquitinated on lysine 327, and this polyubiquitin chain is rapidly removed by ubiquitin carboxyl-terminal hydrolase 16 (USP16) in response to intracellular calcium stimulation.	Lysine	106-112	protein phosphatase 3, catalytic subunit, gamma isoform	Mus musculus	63-69
9182708-8	1997	Proteolytic analysis of wortmannin-prelabelled PI3Kgamma revealed candidate wortmannin-binding peptides around Lys-799.	Lysine	111-114	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	47-56
9182708-11	1997	Parallel inhibition of the PI3Kgamma-associated protein kinase and lipid kinase by wortmannin and by the Lys-799--&gt;Arg mutation reveals that both activities are inherent in the PI3Kgamma polypeptide.	Lysine	105-108	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	27-36
9182708-11	1997	Parallel inhibition of the PI3Kgamma-associated protein kinase and lipid kinase by wortmannin and by the Lys-799--&gt;Arg mutation reveals that both activities are inherent in the PI3Kgamma polypeptide.	Lysine	105-108	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	180-189
31068605-4	2019	We also demonstrate that NEURL1 can promote polyubiquitination of PDE9A that leads to its proteasome-mediated degradation mainly via lysine residue K27 of ubiquitin.	Lysine	133-139	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	25-31
26514304-3	2015	Chaetocin is a compound isolated from fungal cultures and has been reported as a potent and selective inhibitor of suppressor of variegation 3-9 homolog 1 (Suv39h1), which catalyzes histone methylation on histone H3 lysine 9 (H3K9) residues.	Lysine	216-222	suppressor of variegation 3-9 1	Mus musculus	156-163
31068605-4	2019	We also demonstrate that NEURL1 can promote polyubiquitination of PDE9A that leads to its proteasome-mediated degradation mainly via lysine residue K27 of ubiquitin.	Lysine	133-139	phosphodiesterase 9A	Homo sapiens	66-71
9171884-5	1997	The peptide Ac-Nle-c[Asp-His-Phe-Arg-D-Trp9-Ala-Lys]-NH2 demonstrated the greatest differentiation in binding affinity between the hMC1R and hMC4R (78-fold).	Lysine	48-51	melanocortin 1 receptor	Homo sapiens	131-146
26659182-3	2015	Subunits of the chromatin assembly factor-1 (CAF-1) complex, including Chaf1a and Chaf1b, emerged as the most prominent hits from both screens, followed by modulators of lysine sumoylation and heterochromatin maintenance.	Lysine	170-176	chromatin assembly factor 1, subunit B (p60)	Mus musculus	16-43
9149130-2	1997	In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate.	Lysine	80-86	deoxyhypusine synthase	Mus musculus	18-40
30900087-1	2019	Lysyl oxidase-like 4 (LOXL4), a member of the LOX family proteins, catalyzes oxidative deamination of lysine residues in collagen and elastin, which are responsible for maintaining extracellular matrix homeostasis.	Lysine	102-108	elastin	Homo sapiens	134-141
30548332-6	2019	Inhibition or knockdown of JAK2 reduces the H2 O2 -induced chromatin interaction of MSH2, MSH6, DNMT1, and PRC2 members, reduces H2 O2 -induced global increase in trimethylation of lysine 27 of histone H3 (H3K27me3), and abrogates oxidative damage-induced transcriptional repression of candidate TSGs.	Lysine	181-187	DNA methyltransferase 1	Homo sapiens	96-101
26659182-3	2015	Subunits of the chromatin assembly factor-1 (CAF-1) complex, including Chaf1a and Chaf1b, emerged as the most prominent hits from both screens, followed by modulators of lysine sumoylation and heterochromatin maintenance.	Lysine	170-176	chromatin assembly factor 1, subunit B (p60)	Mus musculus	45-50
26189760-4	2015	Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters.	Lysine	204-210	runt related transcription factor 2	Mus musculus	38-73
31450984-4	2019	Identification of abnormal hemoglobin (Hb) using direct DNA sequencing showed a genetic defect causing a delta-globin gene missense mutation at codon 43 (GAG&gt;AAG) causing a glutamic acid to lysine substitution corresponding to Hb A2-Melbourne.	Lysine	193-199	N-methylpurine DNA glycosylase	Homo sapiens	161-164
31002880-0	2019	Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation.	Lysine	27-33	carbonic anhydrase 1	Homo sapiens	101-104
9163585-3	1997	We now present investigations from two HbC compound heterozygotes which exhibit opposing effects upon HbC crystallization: HbC/Hb N-Baltimore (beta95 Lys--&gt;Glu) and HbC/Hb Riyadh (beta120 Lys--&gt;Asn).	Lysine	150-153	keratin 88, pseudogene	Homo sapiens	39-42
9285094-2	1997	This unusual amino acid is produced in a unique posttranslational modification reaction that involves the conjugation of the 4-aminobutyl moiety of the polyamine spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the deoxyhypusine [N epsilon-(4-aminobutyl)lysine] residue and its subsequent hydroxylation.	Lysine	214-220	eukaryotic translation initiation factor 5A	Homo sapiens	236-242
26189760-4	2015	Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters.	Lysine	204-210	runt related transcription factor 2	Mus musculus	75-80
26518673-11	2015	Using LC-MS/MS analysis, a nonenaldehyde post-translational modification was identified on Lysine 235 of the cytoskeletal protein vimentin in whole cell extracts prepared from human end stage ALD hepatic tissue.	Lysine	91-97	vimentin	Homo sapiens	130-138
9121431-0	1997	AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors.	Lysine	101-107	nuclear receptor coactivator 1	Mus musculus	33-63
30896884-11	2019	The association between the levels of P16INK4A, lysine demethylase 6B (KDM6B) and the methylation status of histone 3 lysine 27 (H3K27) in these cell lines and the human USC tumor sample was also demonstrated.	Lysine	48-54	lysine demethylase 6B	Homo sapiens	71-76
32704839-8	2019	Low Lys did not affect feed intake but rather reduced average daily gain (ADG) by 6.35% and the final BW by 3.80% compared with standard Lys (P < 0.001).	Lysine	4-7	ADG	Sus scrofa	74-77
32704839-9	2019	Low Lys reduced ADG (P < 0.001) and gain:feed (P = 0.012) during phase I but not during phase II.	Lysine	4-7	ADG	Sus scrofa	16-19
26548852-6	2015	More importantly, our study uncovers a novel role of an E3 ligase TRAF6, namely, TRAF6 is also able to catalyse Lys 48 polyubiquitylation of target protein except for Lys 63 polyubiquitylation.	Lysine	112-115	TNF receptor associated factor 6	Homo sapiens	66-71
30755420-5	2019	We show here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling.	Lysine	35-41	SH2B adaptor protein 3	Homo sapiens	20-23
30755420-5	2019	We show here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling.	Lysine	35-41	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	84-90
9092626-5	1997	When lysine-38 was replaced by other amino acids, all of the mutants isolated carried the 8-oxo-dGTPase-negative phenotype.	Lysine	5-11	nudix hydrolase 1	Homo sapiens	90-103
9092626-6	1997	8-Oxo-dGTPase-positive revertants, isolated from one of the negative mutants, carried the codon for lysine.	Lysine	100-106	nudix hydrolase 1	Homo sapiens	0-13
9092626-9	1997	We propose that Lys-38, Glu-43, Arg-51 and Glu-52 residues in the conserved region are essential to exert 8-oxo-dGTPase activity.	Lysine	16-19	nudix hydrolase 1	Homo sapiens	106-119
26548852-6	2015	More importantly, our study uncovers a novel role of an E3 ligase TRAF6, namely, TRAF6 is also able to catalyse Lys 48 polyubiquitylation of target protein except for Lys 63 polyubiquitylation.	Lysine	112-115	TNF receptor associated factor 6	Homo sapiens	81-86
30753677-8	2019	Increasing SID lysine increased (quadratic, P &lt; 0.05) ADG and ADFI with pigs fed 0.55% SID lysine having the greatest final BW.	Lysine	15-21	ADG	Sus scrofa	57-60
30753677-10	2019	The quadratic polynomial models predicted maximum ADG and G:F at 0.62 and 0.63% SID lysine, respectively.	Lysine	84-90	ADG	Sus scrofa	50-53
9048556-0	1997	Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine.	Lysine	148-156	dihydrodipicolinate synthase	Escherichia coli	0-28
26124006-9	2015	With respect to XPD codon 751, the chemotherapy sensitivity in NSCLC patients with Lys/Gln genotype was 0.400 times of those with Lys/Lys genotype (P &lt; 0.05).	Lysine	83-86	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	16-19
9003434-5	1997	Lysine-dependent plasminogen binding to r-alpha-enolase was demonstrated by a greater than 80% inhibition of binding by the lysine analogues epsilon-amino caproic acid and tranexamic acid, whilst only 14% inhibition occurred with the arginine analogue benzamidine.	Lysine	0-6	enolase 1	Homo sapiens	42-55
9003434-5	1997	Lysine-dependent plasminogen binding to r-alpha-enolase was demonstrated by a greater than 80% inhibition of binding by the lysine analogues epsilon-amino caproic acid and tranexamic acid, whilst only 14% inhibition occurred with the arginine analogue benzamidine.	Lysine	124-130	enolase 1	Homo sapiens	42-55
30692271-2	2019	RNF20/RNF40-mediated monoubiquitination of histone H2B on lysine 120 (H2Bub) has been suggested as a potential mediator of DSB repair, although the nature and function of this posttranslational modification remain enigmatic.	Lysine	58-64	ring finger protein 40	Mus musculus	6-11
26592444-0	2015	The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.	Lysine	23-29	ubiquitin conjugating enzyme E2 K	Homo sapiens	62-67
30988257-13	2019	Interestingly, another catalytic lysine in PDX1.3 (Lys165) that pivots between the two active sites in PDX1 (P1 and P2), and the corresponding glutamine (Gln169) in PDX1.2, point towards P1, which is distinctive to the initial priming for catalytic action.	Lysine	33-39	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	43-49
30988257-13	2019	Interestingly, another catalytic lysine in PDX1.3 (Lys165) that pivots between the two active sites in PDX1 (P1 and P2), and the corresponding glutamine (Gln169) in PDX1.2, point towards P1, which is distinctive to the initial priming for catalytic action.	Lysine	33-39	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	43-47
30988257-13	2019	Interestingly, another catalytic lysine in PDX1.3 (Lys165) that pivots between the two active sites in PDX1 (P1 and P2), and the corresponding glutamine (Gln169) in PDX1.2, point towards P1, which is distinctive to the initial priming for catalytic action.	Lysine	33-39	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	103-107
8976564-2	1996	We have studied a core-packing mutant of thioredoxin, L78K, in which a leucine residue is substituted by lysine, using 15N heteronuclear two- and three-dimensional NMR.	Lysine	105-111	thioredoxin	Homo sapiens	41-52
9048488-2	1996	Five tumors were found to harbor H-ras mutations where two tumors had a glycine to valine (G--&gt;T) change in codon 12 and three tumors had a glutamine to lysine (C--&gt;A) change in codon 61, respectively.	Lysine	156-162	HRas proto-oncogene, GTPase	Homo sapiens	33-38
25772242-9	2015	We show that MOZ is required to maintain normal levels of histone 3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes.	Lysine	68-74	K(lysine) acetyltransferase 6A	Mus musculus	13-16
8955350-0	1996	Lysine-87 is a functionally important residue in human prothymosin alpha.	Lysine	0-6	prothymosin alpha pseudogene 9	Homo sapiens	55-72
8955350-3	1996	We propose that prothymosin alpha may possess a bipartite rather than monopartite nuclear localization signal, which includes Lys-87, and that the above mutation destroys one part of the nuclear localization signal, thus preventing efficient nuclear uptake of prothymosin alpha.	Lysine	126-129	prothymosin alpha pseudogene 9	Homo sapiens	16-33
30623565-4	2019	Based on the reported prerequisite role of nucleolar stress response in stress-induced p53 protein accumulation, we have also provided evidence suggesting that Sirt1-mediated inhibition on nucleolar stress response may represent a novel mechanism by which Sirt1 can modulate intracellular p53 accumulation independent of lysine deacetylation.	Lysine	321-327	sirtuin 1	Homo sapiens	160-165
30623565-4	2019	Based on the reported prerequisite role of nucleolar stress response in stress-induced p53 protein accumulation, we have also provided evidence suggesting that Sirt1-mediated inhibition on nucleolar stress response may represent a novel mechanism by which Sirt1 can modulate intracellular p53 accumulation independent of lysine deacetylation.	Lysine	321-327	sirtuin 1	Homo sapiens	256-261
30655386-1	2019	Bromodomain and extraterminal (BET) proteins are epigenetic readers that interact with acetylated lysines of histone tails.	Lysine	98-105	delta/notch-like EGF repeat containing	Mus musculus	31-34
30833342-3	2019	It was proposed that the Trithorax system acts via methylation of histone H3 at lysine 4 and lysine 36 (H3K36), thereby inhibiting histone methyltransferase activity of the Polycomb complexes.	Lysine	80-86	trithorax	Drosophila melanogaster	25-34
30833342-3	2019	It was proposed that the Trithorax system acts via methylation of histone H3 at lysine 4 and lysine 36 (H3K36), thereby inhibiting histone methyltransferase activity of the Polycomb complexes.	Lysine	93-99	trithorax	Drosophila melanogaster	25-34
9129159-4	1996	These were a medium hydrophobic residue (Leu or Met) for HLA-A*0201, a basic residue (Arg or Lys) for HLA-B*2705; a small hydrophobic residue (Val) for HLA-A*6801, an acidic residue (Glu) for HLA-B*4001 and a bulky residue (Tyr) for H-2K(d).	Lysine	93-96	major histocompatibility complex, class I, B	Homo sapiens	102-107
26578682-6	2015	We demonstrate that LUBAC activity itself is downregulated through ubiquitination, specifically, ubiquitination of the catalytic subunit HOIP at the carboxyl-terminal lysine 1056.	Lysine	167-173	ring finger protein 31	Homo sapiens	137-141
8931152-0	1996	Evidence for an active T-state pig kidney fructose 1,6-bisphosphatase: interface residue Lys-42 is important for allosteric inhibition and AMP cooperativity.	Lysine	89-92	fructose-bisphosphatase 1	Sus scrofa	42-69
30790655-3	2019	Here we have shown that an increase in histone di-methylation at lysine 9 residue (H3K9Me2), synthesized by the catalytic activity of a histone methyltransferase, G9a is responsible for RGC loss and axonal degeneration in the optic nerve following TBI.	Lysine	65-71	euchromatic histone lysine methyltransferase 2	Homo sapiens	163-166
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	145-151	poly (ADP-ribose) polymerase family, member 1	Mus musculus	106-111
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	157-163	poly (ADP-ribose) polymerase family, member 1	Mus musculus	106-111
30542118-2	2019	Here, using proteomic approach, we identify the transcriptional regulator, OVOL2, is a novel substrate of PARP1 and can be PARylated at residues Lysine 145, Lysine 176, and Lysine 212 within its C2H2 zinc finger domains.	Lysine	157-163	poly (ADP-ribose) polymerase family, member 1	Mus musculus	106-111
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	bromodomain containing 2	Rattus norvegicus	139-143
30132131-3	2019	Finally, this locus contains the lysine (K)-specific demethylase 4C (KDM4C/JMJD2C), which is also relevant for oncogenesis.	Lysine	33-39	lysine demethylase 4C	Homo sapiens	69-74
30132131-3	2019	Finally, this locus contains the lysine (K)-specific demethylase 4C (KDM4C/JMJD2C), which is also relevant for oncogenesis.	Lysine	33-39	lysine demethylase 4C	Homo sapiens	75-81
8858151-4	1996	Hat1p is the catalytic subunit of the histone acetyltransferase and has an intrinsic substrate specificity that modifies lysine in the recognition sequence GXGKXG.	Lysine	121-127	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	0-5
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	bromodomain containing 3	Rattus norvegicus	145-149
26358839-6	2015	Our data indicate that most mitochondrial acetylation occurs as a low-level nonenzymatic protein lesion and that SIRT3 functions as a protein repair factor that removes acetylation lesions from lysine residues.	Lysine	194-200	sirtuin 3	Mus musculus	113-118
8702840-6	1996	Here we further report that NF-H is extensively modified by O-GlcNAc at Thr53, Ser54, and Ser56 in the head domain and, somewhat surprisingly, at multiple sites within the Lys-Ser-Pro repeat motif in the tail domain, a region in assembled neurofilaments known to be nearly stoichiometrically phosphorylated on each of the approximately 50 KSP repeats.	Lysine	172-175	neurofilament heavy chain	Homo sapiens	28-32
8877726-6	1996	Within region 2c, phenylalanine 78 was involved in receptor binding, whereas lysine 54 within region 2a2 participated in gp130 activation.	Lysine	77-83	interleukin 6 cytokine family signal transducer	Homo sapiens	121-126
30840873-2	2019	(2019) report the crystal structure of a lysine-methylated non-histone peptide from DNA ligase 1 (LIG1K126me3) bound to the UHRF1 tandem Tudor domain (TTD).	Lysine	41-47	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	124-129
26342977-4	2015	Mammary abundance of phosphorylated S6K1 was measured as an indicator of mammalian target of rapamycin complex 1 (mTORC1) activity and was found not to be affected by the complete EAA mix but was increased by the mixture lacking Lys.	Lysine	229-232	ribosomal protein S6 kinase B1	Homo sapiens	36-40
30615537-8	2019	LSD1 can demethylate lysine at specific histone positions to repress gene expression or stimulate transcription, indicating a dual and context-dependent role in transcriptional regulation.	Lysine	21-27	lysine demethylase 1A	Homo sapiens	0-4
30369047-4	2019	These coacervates are relevant because they are an essential intermediate assembly stage, where tropoelastin molecules are then cross-linked at lysine residues and integrated into growing elastic fibers.	Lysine	144-150	elastin	Homo sapiens	96-108
30369047-6	2019	Furthermore, it is found that lysine residues show a large variation in their location on the tropoelastin molecule compared with other residues.	Lysine	30-36	elastin	Homo sapiens	94-106
8756332-3	1996	The major determinant for the switch in specificity is the opposite charge of residue 31--Lys in Rap, Glu in Ras--which creates a favourable complementary interface for the Ras-Raf interaction.	Lysine	90-93	LDL receptor related protein associated protein 1	Homo sapiens	97-100
26396186-4	2015	Instead, UCH37, but not a catalytically dead mutant, decreases the Lys-63-linked ubiquitination of E2F1 and activates its transcriptional activity.	Lysine	67-70	E2F transcription factor 1	Homo sapiens	99-103
8806499-3	1996	The possibility of direct interaction between dsRNA and the arginine and lysine-rich region of PKR (residues 54-74) was examined using synthetic peptides.	Lysine	73-79	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	95-98
29981055-4	2019	Jmjd3 participates in different processes such as cell proliferation, apoptosis, differentiation, senescence, and cell reprogramming via demethylation of histone 3 lysine 27 trimethylation status (H3K27 me3).	Lysine	164-170	lysine demethylase 6B	Rattus norvegicus	0-5
8663088-7	1996	Interestingly, the cochaperone DnaJ attenuates the interaction of DnaK with hydrophobic amino acids while strengthening its interaction with arginine or lysine.	Lysine	153-159	DnaJ	Escherichia coli	31-35
26396186-11	2015	These results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63-linked ubiquitination by UCH37.	Lysine	99-102	E2F transcription factor 1	Homo sapiens	44-48
30703547-2	2019	The importance of the histone lysine methyltransferase complex G9a/GLP and its associated histone H3 lysine K9 dimethylation in memory formation and cognition, has garnered the attention of researchers in the past decade.	Lysine	30-36	euchromatic histone lysine methyltransferase 2	Homo sapiens	63-70
26325079-1	2015	Homoisocitrate dehydrogenase (HIcDH) catalyzes the NAD(+)-dependent oxidative decarboxylation of HIc to alpha-ketoadipate, the fourth step in the alpha-aminoadipate pathway responsible for the de novo synthesis of l-lysine in fungi.	Lysine	214-222	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
30996803-1	2019	JMJD3 is a member of the KDM6 subfamily and catalyzes the demethylation of lysine 27 on histone H3 (H3K27).	Lysine	75-81	lysine demethylase 6B	Homo sapiens	0-5
8662881-9	1996	These studies suggest that regions around Lys-1370 and Lys-1374 are involved in lipoprotein receptor-related protein/alpha2M receptor and alpha2M signaling receptor binding, respectively.	Lysine	42-45	alpha-2-macroglobulin	Homo sapiens	117-124
8662881-9	1996	These studies suggest that regions around Lys-1370 and Lys-1374 are involved in lipoprotein receptor-related protein/alpha2M receptor and alpha2M signaling receptor binding, respectively.	Lysine	42-45	alpha-2-macroglobulin	Homo sapiens	138-145
26325079-1	2015	Homoisocitrate dehydrogenase (HIcDH) catalyzes the NAD(+)-dependent oxidative decarboxylation of HIc to alpha-ketoadipate, the fourth step in the alpha-aminoadipate pathway responsible for the de novo synthesis of l-lysine in fungi.	Lysine	214-222	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	30-35
8662881-9	1996	These studies suggest that regions around Lys-1370 and Lys-1374 are involved in lipoprotein receptor-related protein/alpha2M receptor and alpha2M signaling receptor binding, respectively.	Lysine	55-58	alpha-2-macroglobulin	Homo sapiens	117-124
8662881-9	1996	These studies suggest that regions around Lys-1370 and Lys-1374 are involved in lipoprotein receptor-related protein/alpha2M receptor and alpha2M signaling receptor binding, respectively.	Lysine	55-58	alpha-2-macroglobulin	Homo sapiens	138-145
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	SRY-box transcription factor 2	Homo sapiens	211-220
30397178-10	2019	Mechanistically, lnc-LBCS directly binds to heterogeneous nuclear ribonucleoprotein K (hnRNPK) and enhancer of zeste homolog 2 (EZH2), and serves as a scaffold to induce the formation of this complex to repress SRY-box 2 (SOX2) transcription via mediating histone H3 lysine 27 tri-methylation.	Lysine	267-273	SRY-box transcription factor 2	Homo sapiens	222-226
26306033-4	2015	We have discovered that ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase for di- or tri-methylated histone 3 lysine 27 (H3K27me2/3), plays a potential role in regulating brown adipocyte thermogenic program.	Lysine	155-161	lysine (K)-specific demethylase 6A	Mus musculus	91-94
30736831-4	2019	Mutation of a cluster of lysines present in the intracellular N-terminus region of beta-ENaC (K4R/ K5R/ K9R/ K16R/ K23R) reduced interactions with Cav3.2 calcium channels.	Lysine	25-32	sodium channel epithelial 1 subunit beta	Homo sapiens	83-92
24178473-2	1996	It is formed posttranslationally and exclusively in this protein in two consecutive enzymatic reactions, (i) modification of a single lysine residue of the eIF-5A precursor protein by the transfer of the 4-aminobutyl moiety of the polyamine spermidine to itsepsilon-amino group to form the intermediate, deoxyhypusine [N (epsilon) -(4-aminobutyl)lysine] and (ii) subsequent hydroxylation of this intermediate to form hypusine.	Lysine	134-140	eukaryotic translation initiation factor 5A	Homo sapiens	156-162
26320581-8	2015	Finally, our structure explains how the MLL SET domains are able to add multiple methyl groups to the target lysine, despite having the sequence characteristics of a classical monomethylase.	Lysine	109-115	lysine methyltransferase 2A	Homo sapiens	40-43
8639267-7	1996	The Surf-6 long open reading frame encodes a novel highly basic polypeptide of 355 amino acids (28% Arg and Lys).	Lysine	108-111	surfeit gene 6	Mus musculus	4-10
30362103-4	2019	LOXL3 is a member of the lysyl oxidase family of genes which encode enzymes oxidizing the side chain of peptidyl lysine permitting the covalent crosslinking of collagen and elastin chains.	Lysine	113-119	elastin	Homo sapiens	173-180
26283540-2	2015	Transcription of CIITA through the IFN-gamma inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2).	Lysine	166-172	class II major histocompatibility complex transactivator	Homo sapiens	17-22
8631768-9	1996	Nine independent PAI-1 variants share a substitution of P1" (Met347 --&gt; Lys), whereas three others share a P2 substitution (Ala345 --&gt; Asp).	Lysine	75-78	serpin family E member 1	Homo sapiens	17-22
26283540-2	2015	Transcription of CIITA through the IFN-gamma inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2).	Lysine	166-172	class II major histocompatibility complex transactivator	Homo sapiens	55-60
30483796-4	2019	Lysine demethylase 2A (KDM2A), also known as FBXL11 and JHDM1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates EMT and the metastasis of ovarian cancer.	Lysine	80-86	lysine demethylase 2A	Homo sapiens	0-21
30483796-4	2019	Lysine demethylase 2A (KDM2A), also known as FBXL11 and JHDM1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates EMT and the metastasis of ovarian cancer.	Lysine	80-86	lysine demethylase 2A	Homo sapiens	23-28
8652617-0	1996	Identification of cysteine and lysine residues present at the active site of beef liver glutamate dehydrogenase by o-phthalaldehyde.	Lysine	31-37	glutamate dehydrogenase 1	Homo sapiens	88-111
30483796-4	2019	Lysine demethylase 2A (KDM2A), also known as FBXL11 and JHDM1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates EMT and the metastasis of ovarian cancer.	Lysine	80-86	lysine demethylase 2A	Homo sapiens	45-51
26283540-2	2015	Transcription of CIITA through the IFN-gamma inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2).	Lysine	166-172	class II major histocompatibility complex transactivator	Homo sapiens	55-60
30483796-4	2019	Lysine demethylase 2A (KDM2A), also known as FBXL11 and JHDM1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates EMT and the metastasis of ovarian cancer.	Lysine	80-86	lysine demethylase 2A	Homo sapiens	56-62
26377474-7	2015	NAc-specific downregulation of PRMT1 leads to hypomethylation of H4R3me2a, and hypoacetylation of histone H3 lysine 9 and 14.	Lysine	109-115	protein arginine N-methyltransferase 1	Mus musculus	31-36
30622182-6	2019	Mechanistically, we found that during mitosis SETD6 binds and methylates PLK1 on two lysine residues: K209 and K413.	Lysine	85-91	polo like kinase 1	Homo sapiens	73-77
8700829-0	1996	The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.	Lysine	76-82	CD248 molecule	Homo sapiens	98-103
8599236-16	1996	However, chemical modification of as few as three of the 29 lysine residues of apo H destroyed binding, indicating that one or a few lysines in apo H are involved in rHBsAg binding.	Lysine	60-66	apolipoprotein H	Homo sapiens	79-84
8599236-16	1996	However, chemical modification of as few as three of the 29 lysine residues of apo H destroyed binding, indicating that one or a few lysines in apo H are involved in rHBsAg binding.	Lysine	133-140	apolipoprotein H	Homo sapiens	144-149
26377474-14	2015	Additionally, genetic downregulation of PRMT1 in NAc also attenuated cocaine-caused CPP and locomotion activity, which was associated with decreased expression of histone H4 arginine 3 asymmetric demethylation (H4R3me2a) and hypoacetylation of histone H3 lysine 9 and 14 (acH3K9/K14).	Lysine	255-261	protein arginine N-methyltransferase 1	Mus musculus	40-45
29077881-6	2019	These changes were associated with reduced di-(H3K9me2) and trimethylation (H3K9me3) as well as acetylation (H3K9ac) of histone 3 lysine 9 (H3K9) on p66Shc promoter.	Lysine	130-136	src homology 2 domain-containing transforming protein C1	Mus musculus	149-155
26356530-3	2015	Here, we report that PGK1 is acetylated at lysine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP.	Lysine	43-49	phosphoglycerate kinase 1	Homo sapiens	21-25
30573668-4	2019	We report that following mitochondrial damage-induced mitophagy, Parkin directly ubiquitinates the apoptotic effector protein BAK at a conserved lysine in its hydrophobic groove, a region that is crucial for BAK activation by BH3-only proteins and its homo-dimerisation during apoptosis.	Lysine	145-151	BCL2 antagonist/killer 1	Homo sapiens	126-129
30573668-4	2019	We report that following mitochondrial damage-induced mitophagy, Parkin directly ubiquitinates the apoptotic effector protein BAK at a conserved lysine in its hydrophobic groove, a region that is crucial for BAK activation by BH3-only proteins and its homo-dimerisation during apoptosis.	Lysine	145-151	BCL2 antagonist/killer 1	Homo sapiens	208-211
30442713-5	2019	Our studies showed that L3MBTL3 preferentially binds to the methylated Lys-42 in SOX2, although mutation of Lys-117 also partially reduces the interaction between SOX2 and L3MBTL3.	Lysine	71-74	SRY (sex determining region Y)-box 2	Mus musculus	81-85
30442713-5	2019	Our studies showed that L3MBTL3 preferentially binds to the methylated Lys-42 in SOX2, although mutation of Lys-117 also partially reduces the interaction between SOX2 and L3MBTL3.	Lysine	108-111	SRY (sex determining region Y)-box 2	Mus musculus	163-167
26356530-3	2015	Here, we report that PGK1 is acetylated at lysine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP.	Lysine	43-49	phosphoglycerate kinase 1	Homo sapiens	77-81
30442713-8	2019	We also found that retinoic acid-induced differentiation of mouse ES cells is accompanied by the enhanced degradation of the methylated SOX2 protein at both Lys-42 and Lys-117.	Lysine	157-160	SRY (sex determining region Y)-box 2	Mus musculus	136-140
30442713-8	2019	We also found that retinoic acid-induced differentiation of mouse ES cells is accompanied by the enhanced degradation of the methylated SOX2 protein at both Lys-42 and Lys-117.	Lysine	168-171	SRY (sex determining region Y)-box 2	Mus musculus	136-140
8646816-15	1996	The above findings suggest that lysine derivatives react with bovine plasmin and then stabilize the activity of plasmin by preventing the degradation of active fragment (Met343-Asn786).	Lysine	32-38	plasminogen	Bos taurus	69-76
8646816-15	1996	The above findings suggest that lysine derivatives react with bovine plasmin and then stabilize the activity of plasmin by preventing the degradation of active fragment (Met343-Asn786).	Lysine	32-38	plasminogen	Bos taurus	112-119
8579602-0	1996	Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.	Lysine	0-6	secretin receptor	Rattus norvegicus	51-68
26321253-5	2015	Further, SUMO-RanGAP1 bound to the N-terminal lysine 56 of SLP-76 where the interaction was needed for optimal RanGAP1-NPC localization and GAP exchange activity.	Lysine	46-52	Ran GTPase activating protein 1	Homo sapiens	14-21
30626866-1	2019	Histone demethylase KDM5A removes methyl marks from lysine 4 of histone H3 and is often overexpressed in cancer.	Lysine	52-58	lysine demethylase 5A	Homo sapiens	20-25
26321253-5	2015	Further, SUMO-RanGAP1 bound to the N-terminal lysine 56 of SLP-76 where the interaction was needed for optimal RanGAP1-NPC localization and GAP exchange activity.	Lysine	46-52	Ran GTPase activating protein 1	Homo sapiens	111-118
26142902-4	2015	rLap1 showed the highest activity against Arg-pNA and then Leu-, Lys-, Met-, and Phe-pNA.	Lysine	65-68	alanyl aminopeptidase, membrane	Rattus norvegicus	0-5
30409904-3	2019	Here, using Bcl6 -/- knockout mice, HEK293A and HCT116 p53 -/- cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage-induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1.	Lysine	175-178	BCL6 transcription repressor	Homo sapiens	115-119
8768330-3	1996	In amino acid sequence of ALG2 protein extensive symmetrical segments were identified, in particular, 230-452 segment symmetrical relatively to Lys 346.	Lysine	144-147	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	26-30
8633765-0	1995	Structural study of electrolysis-induced degradation of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.	Lysine	117-120	ghrelin and obestatin prepropeptide	Homo sapiens	60-92
26280580-2	2015	Dominant mutations in the chromatin regulators lysine (K)-specific methyltransferase 2D (KMT2D) (also known as MLL2) and lysine (K)-specific demethylase 6A (KDM6A) underlie the majority of cases.	Lysine	47-53	lysine methyltransferase 2D	Homo sapiens	89-94
7588717-9	1995	The deduced amino acid sequence of hG1.16 was identical to rat ribosomal protein L37 that contained 97 amino acids, many of which are highly positively charged (15 arginine and 14 lysine residues with a predicted M(r) of 11,065).	Lysine	180-186	ribosomal protein L37	Homo sapiens	35-41
30523148-5	2019	Within this TDG-BERosome, SUMO is transferred from XRCC1 and coupled to the SUMO acceptor lysine in TDG, promoting its dissociation while assuring the engagement of the BER machinery to complete demethylation.	Lysine	90-96	thymine DNA glycosylase	Mus musculus	12-15
30523148-5	2019	Within this TDG-BERosome, SUMO is transferred from XRCC1 and coupled to the SUMO acceptor lysine in TDG, promoting its dissociation while assuring the engagement of the BER machinery to complete demethylation.	Lysine	90-96	X-ray repair complementing defective repair in Chinese hamster cells 1	Mus musculus	51-56
30523148-5	2019	Within this TDG-BERosome, SUMO is transferred from XRCC1 and coupled to the SUMO acceptor lysine in TDG, promoting its dissociation while assuring the engagement of the BER machinery to complete demethylation.	Lysine	90-96	thymine DNA glycosylase	Mus musculus	100-103
26280580-2	2015	Dominant mutations in the chromatin regulators lysine (K)-specific methyltransferase 2D (KMT2D) (also known as MLL2) and lysine (K)-specific demethylase 6A (KDM6A) underlie the majority of cases.	Lysine	47-53	lysine methyltransferase 2D	Homo sapiens	111-115
30201289-6	2019	Additionally, ACSF3-derived malonyl-CoA can be used to malonylate lysine residues on proteins within the matrix of mitochondria, possibly adding another regulatory layer to post-translational control of mitochondrial metabolism.	Lysine	66-72	acyl-CoA synthetase family member 3	Homo sapiens	14-19
7567989-3	1995	We show that elongation factor 1 alpha (EF-1 alpha) is overexpressed in opaque2 endosperm compared with its normal counterpart and that there is a highly significant correlation between EF-1 alpha concentration and the total lysine content of the endosperm.	Lysine	225-231	elongation factor 1-alpha	Zea mays	13-50
26244656-8	2015	A lysine 37 site mutant (K37R) was transfected into EGFR deficient cells.	Lysine	2-8	epidermal growth factor receptor	Mus musculus	52-56
7567989-3	1995	We show that elongation factor 1 alpha (EF-1 alpha) is overexpressed in opaque2 endosperm compared with its normal counterpart and that there is a highly significant correlation between EF-1 alpha concentration and the total lysine content of the endosperm.	Lysine	225-231	elongation factor 1-alpha	Zea mays	40-50
30400007-4	2019	The goal of this study is to establish the functional link between histone acetyltransferase lysine (K) acetyltransferase 5 (KAT5, a critical DDR protein) and ATC invasiveness using clinical, in vitro and in vivo models.	Lysine	93-99	lysine acetyltransferase 5	Homo sapiens	125-129
26287632-3	2015	We demonstrate our method by measuring the conformational changes that occur upon ligand binding with three well-characterized proteins labeled at lysine residues: calmodulin (CaM), maltose-binding protein (MBP), and dihydrofolate reductase (DHFR).	Lysine	147-153	dihydrofolate reductase	Homo sapiens	217-240
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	58-62
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	64-86
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	101-106
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	108-134
8546864-1	1995	The effects of exogenous insulin, glucagon and streptozotocin-diabetes on influx (15 s) of L-lysine via a cationic amino acid transporter resembling system y+ were investigated in the isolated perfused rat pancreas.	Lysine	91-99	insulin	Bos taurus	25-32
8546864-3	1995	Bovine insulin (100 mu u ml-1) increased the maximal transport rate (Vmax = 3.49 +/- 0.30 mumol min-1 g-1, n = 4, P &lt; 0.05) for L-lysine 1.6-fold without altering the Km.	Lysine	131-139	insulin	Bos taurus	7-14
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	180-184
26287632-3	2015	We demonstrate our method by measuring the conformational changes that occur upon ligand binding with three well-characterized proteins labeled at lysine residues: calmodulin (CaM), maltose-binding protein (MBP), and dihydrofolate reductase (DHFR).	Lysine	147-153	dihydrofolate reductase	Homo sapiens	242-246
29969578-5	2019	Mechanistically, SENP2 as a specific de-SUMOylase targets NDR1 (nuclear Dbf2-related 1), also called STK38 (serine-threonine kinase 38), for de-SUMOylation and SUMO conjugation of NDR1 on Lys-465 attenuates its inhibition of p38/ERK1/2 activation by decreasing the association of NDR1 with MEK kinase 1/2.	Lysine	188-191	serine/threonine kinase 38	Homo sapiens	180-184
7649542-2	1995	We found that two common alleles, C8A*A and C8A*B, are characterized by the substitution of a single amino acid (Gln to Lys), which is caused by a point mutation of a single nucleotide (C to A) in exon 3 at position 187 of the mature C8 alpha cDNA sequence.	Lysine	120-123	complement C8 alpha chain	Homo sapiens	34-37
26101372-6	2015	Ube2W targets multiple TRIM5alpha internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal amino group, which is instead alphaN-acetylated in cells.	Lysine	70-77	ubiquitin conjugating enzyme E2 W	Homo sapiens	0-5
7649542-2	1995	We found that two common alleles, C8A*A and C8A*B, are characterized by the substitution of a single amino acid (Gln to Lys), which is caused by a point mutation of a single nucleotide (C to A) in exon 3 at position 187 of the mature C8 alpha cDNA sequence.	Lysine	120-123	complement C8 alpha chain	Homo sapiens	44-47
7649542-2	1995	We found that two common alleles, C8A*A and C8A*B, are characterized by the substitution of a single amino acid (Gln to Lys), which is caused by a point mutation of a single nucleotide (C to A) in exon 3 at position 187 of the mature C8 alpha cDNA sequence.	Lysine	120-123	complement C8 alpha chain	Homo sapiens	234-242
30467903-10	2019	The average optimal SID SAA:Lys ratio for maximal ADG and G:F and minimal PUN was 65.2% using curvilinear-plateau and linear broken-line models.	Lysine	28-31	ADG	Sus scrofa	50-53
26001790-3	2015	BRCC3 is a member of the JAMM/MPN+ family of zinc metalloproteases capable of cleaving Lys-63 linked polyubiquitin chains, and is implicated in DNA repair.	Lysine	87-90	BRCA1/BRCA2-containing complex, subunit 3	Mus musculus	0-5
29925903-1	2019	Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372.	Lysine	169-175	growth factor independent 1 transcription repressor	Mus musculus	0-27
29925903-1	2019	Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372.	Lysine	169-175	growth factor independent 1 transcription repressor	Mus musculus	29-33
7595465-6	1995	This Tm lowering is also achieved by two less drastic techniques that do not remove histone H-1, but decrease the affinity of the H-1 to the DNA: (1) a mild acetylation procedure that specifically modifies either 2 or 4 epsilon-amino groups of lysines on the H-1 histone, and (2) reaction with phosphate-binding divalent metal ions, e.g., Mg(II), Mn(II), or Co(II).	Lysine	244-251	H1.5 linker histone, cluster member	Homo sapiens	130-133
7595465-6	1995	This Tm lowering is also achieved by two less drastic techniques that do not remove histone H-1, but decrease the affinity of the H-1 to the DNA: (1) a mild acetylation procedure that specifically modifies either 2 or 4 epsilon-amino groups of lysines on the H-1 histone, and (2) reaction with phosphate-binding divalent metal ions, e.g., Mg(II), Mn(II), or Co(II).	Lysine	244-251	H1.5 linker histone, cluster member	Homo sapiens	130-133
31256381-2	2019	Characteristic mass shifts and fragment ions indicating ubiquitinated lysine residues in tryptic and gluC digests are discussed.	Lysine	70-76	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	101-105
26216063-9	2015	Moreover, a lysine at residue 13 is also exposed and when ubiquitinated, transports PTEN to the nucleus.	Lysine	12-18	phosphatase and tensin homolog	Homo sapiens	84-88
30483785-3	2019	The olfactory bromodomain-containing protein 4 (BRD4) is a protein that recognizes and binds acetylated lysine.	Lysine	104-110	bromodomain containing 4	Rattus norvegicus	14-46
30483785-3	2019	The olfactory bromodomain-containing protein 4 (BRD4) is a protein that recognizes and binds acetylated lysine.	Lysine	104-110	bromodomain containing 4	Rattus norvegicus	48-52
7627718-6	1995	Chemical modification of LDL apoB lysines or arginines markedly reduced the ability of the lipoprotein to block the binding of 125I-LDL to LPL-containing matrix, suggesting that apoB positively charged amino acids are involved in the interaction.	Lysine	34-41	lipoprotein lipase	Homo sapiens	139-142
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Lysine	40-43	5', 3'-nucleotidase, cytosolic	Homo sapiens	108-111
7539797-8	1995	Analysis of this model indicated that the alteration of one E-selectin amino acid, alanine 77, to a lysine residue might shift binding specificity from sLe(x) to mannose.	Lysine	100-106	selectin E	Homo sapiens	60-70
30733656-4	2019	The N399K substitution renders GDF6 more similar to noggin-resistant members of the BMP family, namely GDF2 and BMP10, both of which contain lysine in the corresponding position.	Lysine	141-147	growth differentiation factor 6	Homo sapiens	31-35
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	lysine demethylase 1A	Homo sapiens	122-126
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	C-C motif chemokine ligand 5	Homo sapiens	211-239
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	C-C motif chemokine ligand 5	Homo sapiens	241-245
25999347-3	2015	In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1 to the site of DNA damage promotes local H3K4me2 demethylation and ubiquitination of H2A/H2AX, facilitating 53BP1 recruitment to sites of DNA damage.	Lysine	63-69	tumor protein p53 binding protein 1	Homo sapiens	204-209
30373773-9	2018	In human OSM, Lys-44 appeared to be the main residue preventing mouse OSMR activation.	Lysine	14-17	oncostatin M receptor	Mus musculus	70-74
7796890-6	1995	Inhibition of plasminogen activation occurred with plasminogen activator inhibitor-1, anti-catalytic anti-tissue-plasminogen activator antibody, epsilon-aminocaproic acid, which inhibits the binding of plasminogen through its lysine binding sites, and amiloride, which specifically inhibits urokinase.	Lysine	226-232	plasminogen activator, tissue type	Rattus norvegicus	106-134
7791116-4	1995	In vivo, LY 165,163 behaved as an antagonist at D2 autoreceptors in enhancing the synthesis of dopamine throughout the brain.	Lysine	9-11	solute carrier family 3 member 1	Rattus norvegicus	48-50
7791116-5	1995	Consistently with antagonist properties at postsynaptic D2 receptors, in unilateral substantia nigra-lesioned rats, the rotation elicited by the D2 agonist quinpirole was potently blocked by LY 165,163, whereas that elicited by the D1 agonist SKF 38393 was only weakly inhibited.	Lysine	191-193	solute carrier family 3 member 1	Rattus norvegicus	56-58
7791116-5	1995	Consistently with antagonist properties at postsynaptic D2 receptors, in unilateral substantia nigra-lesioned rats, the rotation elicited by the D2 agonist quinpirole was potently blocked by LY 165,163, whereas that elicited by the D1 agonist SKF 38393 was only weakly inhibited.	Lysine	191-193	solute carrier family 3 member 1	Rattus norvegicus	145-147
26119818-4	2015	Moreover, a genotype-phenotype correlation was observed, because the two syndromes differed based solely upon the nature of the substituting amino acid: a lysine at TWIST2 residue 75 resulted in AMS, whereas a glutamine or alanine yielded BSS.	Lysine	155-161	twist family bHLH transcription factor 2	Homo sapiens	165-171
7791116-7	1995	At native rat 5-HT1A receptors and cloned human 5-HT1A receptors, LY 165,163 (pKi values of 8.7 and 8.9, respectively) mimicked the high affinity of 8-OH-DPAT (pKi values of 9.0 and 9.2).	Lysine	66-68	5-hydroxytryptamine receptor 1A	Homo sapiens	14-20
30006927-5	2018	GATA3 expression associates with poor prognosis of ovarian HGSC patients, and was found to recruit the histone H3, lysine 27 (H3K27) demethylase, UTX, activate stemness markers, and promote stem-like phenotypes in ovarian HGSC cell lines.	Lysine	115-121	GATA binding protein 3	Homo sapiens	0-5
26008206-4	2015	After recruitment to depolarized mitochondria, Parkin mediates poly-ubiquitination of Mff at lysine 251.	Lysine	93-99	mitochondrial fission factor	Homo sapiens	86-89
30472208-2	2018	Upon interacting with RIG-I, MAVS undergoes lysine 63-linked poly-ubiquitination by the E3 ligase TRIM31 and subsequently aggregates to activate downstream signaling effectors.	Lysine	44-50	DEAD/H box helicase 58	Mus musculus	22-27
30472208-2	2018	Upon interacting with RIG-I, MAVS undergoes lysine 63-linked poly-ubiquitination by the E3 ligase TRIM31 and subsequently aggregates to activate downstream signaling effectors.	Lysine	44-50	mitochondrial antiviral signaling protein	Mus musculus	29-33
30472208-2	2018	Upon interacting with RIG-I, MAVS undergoes lysine 63-linked poly-ubiquitination by the E3 ligase TRIM31 and subsequently aggregates to activate downstream signaling effectors.	Lysine	44-50	tripartite motif-containing 31	Mus musculus	98-104
7667330-3	1995	In contrast, the arylpiperazine 5-HT1A receptor agonists, LY 165,163 and tandospirone, increased punished responding only at higher doses (MED: 0.16 and 0.63 mg/kg, respectively), and also with a lesser maximal effect (2065% and 3695%, respectively).	Lysine	58-60	5-hydroxytryptamine receptor 1A	Homo sapiens	32-47
7537094-5	1995	Both K111C and K113C displayed significantly reduced binding activity compared to the wild-type P-selectin from which they were derived, further illustrating the importance of these particular lysines for ligand binding.	Lysine	193-200	selectin P	Homo sapiens	96-106
25943393-3	2015	Using nucleotide diversity data, we show that there is a single fixed nucleotide difference between maize and teosinte in tga1, and this difference confers a Lys (teosinte allele) to Asn (maize allele) substitution.	Lysine	158-161	teosinte glume architecture 1	Zea mays	122-126
7534039-2	1995	We describe a family with an autosomal dominant skin-blistering disorder, epidermolysis bullosa simplex, Koebner subtype (EBS-K), that has a novel point mutation, occurring in the keratin 5 gene (KRT5), that predicts the substitution of an evolutionarily conserved lysine by an asparagine residue (K173N).	Lysine	265-271	keratin 5	Homo sapiens	180-189
7534039-2	1995	We describe a family with an autosomal dominant skin-blistering disorder, epidermolysis bullosa simplex, Koebner subtype (EBS-K), that has a novel point mutation, occurring in the keratin 5 gene (KRT5), that predicts the substitution of an evolutionarily conserved lysine by an asparagine residue (K173N).	Lysine	265-271	keratin 5	Homo sapiens	196-200
30540930-3	2018	Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deacetylated by SIRT7.	Lysine	48-54	fibrillarin	Homo sapiens	19-22
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	148-151	sirtuin 1	Homo sapiens	109-114
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	sirtuin 1	Homo sapiens	109-114
30327428-6	2018	ATR-mediated phosphorylation of XPA on Ser-196 enhances cAMP-mediated optimization of NER and is promoted by SIRT1-mediated deacetylation of XPA on Lys-63, Lys-67, and Lys-215.	Lysine	156-159	sirtuin 1	Homo sapiens	109-114
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	151-154	sirtuin 1	Homo sapiens	38-43
30327428-8	2018	Our study identifies a regulatory ATR-SIRT1-XPA axis in cAMP-mediated regulation melanocyte genomic stability, involving SIRT1-mediated deacetylation (Lys-63, Lys-67, and Lys-215) and ATR-dependent phosphorylation (Ser-196) post-translational modifications of the core NER factor XPA.	Lysine	151-154	sirtuin 1	Homo sapiens	121-126
26113394-5	2015	Furthermore, the alkaline hydrolysis technology appeared efficient for the purification and packaging of four different HBc variants carrying lysine residues on the HBc VLP spikes.	Lysine	142-148	keratin 88, pseudogene	Homo sapiens	120-123
30327434-8	2018	Knockdown of Ezh2 in chondrocyte micromass cultures resulted in a global reduction in trimethylation of histone 3 lysine 27 (H3K27me3) and altered differentiation in vitro RNA-Seq analysis revealed enrichment of an osteogenic gene expression profile in Ezh2-deficient chondrocytes.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	13-17
29753027-1	2018	Jumonji domain-containing protein D3 (JMJD3), a histone 3 lysine 27 (H3K27) demethylase, has been extensively studied for their participation in development, cellular physiology and a variety of diseases.	Lysine	58-64	lysine demethylase 6B	Homo sapiens	0-36
29753027-1	2018	Jumonji domain-containing protein D3 (JMJD3), a histone 3 lysine 27 (H3K27) demethylase, has been extensively studied for their participation in development, cellular physiology and a variety of diseases.	Lysine	58-64	lysine demethylase 6B	Homo sapiens	38-43
7539160-9	1995	Lys in position 144 and His in position 151 are apparently critical for RG1 binding.	Lysine	0-3	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	72-75
7875321-6	1995	A single lysine residue in the N-terminal domain is an essential requirement for transglutaminase-mediated oligomerization, and two equivalent glutamine residues present in identical sequence repeats within this domain appear to be involved as amine acceptors in cross-linking reactions.	Lysine	9-15	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	81-97
26113394-5	2015	Furthermore, the alkaline hydrolysis technology appeared efficient for the purification and packaging of four different HBc variants carrying lysine residues on the HBc VLP spikes.	Lysine	142-148	keratin 88, pseudogene	Homo sapiens	165-168
26113394-6	2015	Utilising the introduced lysine residues and the intrinsic aspartic and glutamic acid residues exposed on the tips of the HBc spikes for chemical coupling of the chosen peptide and/or nucleic acid sequences ensured a standard and easy protocol for the further development of versatile HBc VLP-based vaccine and gene therapy applications.	Lysine	25-31	keratin 88, pseudogene	Homo sapiens	122-125
30098999-4	2018	Our results show that knockdown of FolR1 and/or Rfc1 reduced the abundance of histone H3 lysine and DNA methylation, two epigenetic modifications that play an important role during neural and neural crest development.	Lysine	89-95	replication factor C subunit 1	Homo sapiens	48-52
7852404-13	1995	Based on the crystal structure of cytochrome c we putatively assign the invariant Asn-52 (horse heart cytochrome c) as the site liganding the protonated phosphate of the lipid, whereas Lys-72 and -73 should bind the deprotonated form.	Lysine	185-188	cytochrome c, somatic	Equus caballus	34-46
26115316-1	2015	The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively.	Lysine	110-116	methyltransferase 21A, HSPA lysine	Homo sapiens	38-46
7735837-0	1995	Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.	Lysine	49-55	cyclin dependent kinase 20	Homo sapiens	123-128
7735837-2	1995	The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk.	Lysine	18-24	cyclin dependent kinase 20	Homo sapiens	132-137
7735837-7	1995	CONCLUSIONS: The c-Crk SH3 domain engages in an unusual lysine-specific interaction that is rarely seen in protein structures, and which appears to be a key determinant of its unique ability to bind the C3G peptides with high affinity.	Lysine	56-62	cyclin dependent kinase 20	Homo sapiens	17-22
30381828-1	2018	Using methods combining cross-linking, pull-down assays, and stable isotope labeling by amino acids in cell culture with mass spectrometry, we identified that the Tudor domain-containing protein Spindlin-1 recognizes trimethylation of histone H4 lysine 20 (H4K20me3).	Lysine	246-252	spindlin 1	Homo sapiens	195-205
26115316-1	2015	The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively.	Lysine	110-116	valosin containing protein lysine methyltransferase	Homo sapiens	51-58
26115316-1	2015	The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively.	Lysine	110-116	valosin containing protein lysine methyltransferase	Homo sapiens	60-68
25689365-1	2015	Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion of a specific Lys to hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)lysine].	Lysine	173-176	eukaryotic translation initiation factor 5A	Homo sapiens	0-43
30306644-6	2018	After LPS injection, decreased VISTA expression in mouse microglia was accompanied by decreased acetylation of lysine residue 27 in histone 3 in both its promoter and enhancer region.	Lysine	111-117	V-set immunoregulatory receptor	Mus musculus	31-36
30128672-2	2018	Several studies revealed that HSP47 has a role in numerous steps of collagen synthesis, preventing procollagen aggregation and inducing hydroxylation of proline and lysine residues.	Lysine	165-171	serpin family H member 1	Homo sapiens	30-35
7827055-1	1995	A novel photoinduced electron-transfer reaction is reported in complexes between resting ferric state cytochrome c peroxidase (CcP) and several horse cytochrome c derivatives labeled at single lysine amino groups with [bis(bipyridine)](dicarboxybipyridine)ruthenium(II) (Ru-CC).	Lysine	193-199	cytochrome c, somatic	Equus caballus	102-114
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Lysine	129-132	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	81-84
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Lysine	129-132	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	155-158
25689365-1	2015	Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion of a specific Lys to hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)lysine].	Lysine	173-176	eukaryotic translation initiation factor 5A	Homo sapiens	45-50
30809370-5	2019	Crystallographic studies of peptide-MDM2/MDMX complexes structurally validated the chemoselectivity of the dithiocarbamate staple bridging Lys and Cys at (i, i + 4) positions.	Lysine	139-142	MDM2 proto-oncogene	Homo sapiens	36-40
26090800-5	2015	Mutational and reporter gene analyses identified five different lysine residues at K13, K308, K361, K379 and K391 as SUMO acceptor sites.	Lysine	64-70	keratin 13	Homo sapiens	83-86
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	117-120	sirtuin 7	Homo sapiens	89-94
30282801-3	2018	Using co-expression in HEK293T cells and co-immunoprecipitation assays, we observed that SIRT7 deacetylates WDR77 at Lys-3 and Lys-243, which reduced of WDR77"s interaction with PRMT5.	Lysine	127-130	sirtuin 7	Homo sapiens	89-94
30424580-8	2018	In addition, we determined that following the loss of Kat2a activity, overall histone 3 lysine 9 (H3K9) acetylation, the main epigenetic target of Kat2a/Kat2b, was decreased.	Lysine	88-94	K(lysine) acetyltransferase 2A	Mus musculus	54-59
7832769-1	1995	Simplified procedures for assaying and purifying dihydrodipicolinate synthase (EC 4.2.1.52), the first enzyme of the lysine biosynthetic pathway, have been developed and electrospray ionization m.s.	Lysine	117-123	dihydrodipicolinate synthase	Escherichia coli	49-77
7814384-4	1995	Also, these results showed that Lys-10 and Lys-116 are involved in the interaction of bovine PLA2 with anionic interfaces but not in the interaction with the active site-bound substrate.	Lysine	32-35	LOC104974671	Bos taurus	93-97
30424580-8	2018	In addition, we determined that following the loss of Kat2a activity, overall histone 3 lysine 9 (H3K9) acetylation, the main epigenetic target of Kat2a/Kat2b, was decreased.	Lysine	88-94	K(lysine) acetyltransferase 2A	Mus musculus	147-152
7814384-4	1995	Also, these results showed that Lys-10 and Lys-116 are involved in the interaction of bovine PLA2 with anionic interfaces but not in the interaction with the active site-bound substrate.	Lysine	43-46	LOC104974671	Bos taurus	93-97
26010904-9	2015	CHIP ubiquitination with the E2 enzyme Ube2W is predominantly directed to the N-terminal amine of the substrate; however, some internal lysine modifications were also detected.	Lysine	136-142	ubiquitin conjugating enzyme E2 W	Homo sapiens	39-44
7814384-7	1995	These findings establish Lys-56 and Lys-116 as essential residues for the binding of bovine pancreatic PLA2 to anionic interfaces.	Lysine	25-28	LOC104974671	Bos taurus	103-107
7814384-7	1995	These findings establish Lys-56 and Lys-116 as essential residues for the binding of bovine pancreatic PLA2 to anionic interfaces.	Lysine	36-39	LOC104974671	Bos taurus	103-107
30228186-10	2018	Combined, our studies strongly suggest that posttranslational modification(s), including sumoylation mediated by Lys-42, plays a crucial role in K-Ras activities in vivo.	Lysine	113-116	KRAS proto-oncogene, GTPase	Homo sapiens	145-150
25905789-2	2015	Here, using an LC-MS/MS chemoproteomics platform based on a lysine-reactive ATP acyl phosphate probe, several Hsp90 inhibitors were profiled in native cell lysates.	Lysine	60-66	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
30104272-5	2018	Poly-l-lysine (pLK) is a cationic polypeptide possessing antibacterial properties and mucolytic activity by compacting DNA.	Lysine	0-13	polo like kinase 1	Homo sapiens	15-18
7711105-2	1995	The lysine carboxyl group can then be activated as a succinimidyl ester to obtain a new mPEG derivative (mPEG2-COOSu) with improved properties for biotechnical applications.	Lysine	4-10	insulin-like growth factor 2	Mus musculus	105-110
8589066-7	1995	The rate constant for this reaction is 6 x 10(4) s-1 for a horse Ru-cytochrome c derivative labeled at lysine 27, and greater than 10(6) s-1 for yeast Ru-cytochrome c derivatives.	Lysine	103-109	cytochrome c, somatic	Equus caballus	68-80
8589066-7	1995	The rate constant for this reaction is 6 x 10(4) s-1 for a horse Ru-cytochrome c derivative labeled at lysine 27, and greater than 10(6) s-1 for yeast Ru-cytochrome c derivatives.	Lysine	103-109	cytochrome c, somatic	Equus caballus	154-166
30341286-1	2018	Despite the established oncogenic and profibrotic functions of enhancer of zeste homolog 2 (EZH2), a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3), its role in acute kidney injury (AKI) remains unclear.	Lysine	143-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	63-90
25807213-3	2015	However, homocysteine can be recognized and activated by methionyl-tRNA synthetase (MetRs) to produce Hcy-thiolactone (HTL), which can react with the epsilon-amino group of a protein lysine residue.	Lysine	183-189	methionyl-tRNA synthetase 1	Homo sapiens	57-82
30341286-1	2018	Despite the established oncogenic and profibrotic functions of enhancer of zeste homolog 2 (EZH2), a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3), its role in acute kidney injury (AKI) remains unclear.	Lysine	143-149	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	92-96
7749197-8	1995	Functional studies support the idea that this domain is not required for guanine nucleotide binding since prenylation-defective mutants still bind GDP and are protected from protease digestion in the presence of GTP gamma S. We conclude that the mechanism of Rab geranylgeranylation involves key elements of the protein"s tertiary structure including a conserved N-terminal amino acid motif (YXYLFK) that incorporates a critical lysine residue.	Lysine	429-435	RAB5A, member RAS oncogene family	Homo sapiens	259-262
25807213-3	2015	However, homocysteine can be recognized and activated by methionyl-tRNA synthetase (MetRs) to produce Hcy-thiolactone (HTL), which can react with the epsilon-amino group of a protein lysine residue.	Lysine	183-189	methionyl-tRNA synthetase 1	Homo sapiens	84-89
30205953-0	2018	Acetylation of lysine residues in the recombinant nucleoprotein and VP40 matrix protein of Zaire Ebolavirus by eukaryotic histone acetyltransferases.	Lysine	15-21	matrix protein	Zaire ebolavirus	68-72
30205953-5	2018	Mass spectrometry was used to identify the lysine residues that were potential acetylation targets in NP and VP40.	Lysine	43-49	matrix protein	Zaire ebolavirus	109-113
30205953-7	2018	Potentially acetylated lysine targets in VP40 were identified in the basic patch, which is necessary for constructing oligomers.	Lysine	23-29	matrix protein	Zaire ebolavirus	41-45
7989313-0	1994	A single mutation at lysine 426 of human placental S-adenosylhomocysteine hydrolase inactivates the enzyme.	Lysine	21-27	adenosylhomocysteinase	Homo sapiens	51-83
25921090-4	2015	NAMPT mutants reveal that SIRT1 deacetylates lysine 53 (K53) and enhances eNAMPT activity and secretion.	Lysine	45-51	sirtuin 1	Mus musculus	26-31
30286792-4	2018	One of the identified substrates, activating transcriptional factor 7-interacting protein 1 (ATF7IP), is tri-methylated at a histone H3 lysine 9 (H3K9)-like mimic by the G9a/GLP complex, although this complex mainly introduces di-methylation on H3K9 and DNA ligase 1 (LIG1) K126 in cells.	Lysine	136-142	activating transcription factor 7 interacting protein	Homo sapiens	34-91
30286792-4	2018	One of the identified substrates, activating transcriptional factor 7-interacting protein 1 (ATF7IP), is tri-methylated at a histone H3 lysine 9 (H3K9)-like mimic by the G9a/GLP complex, although this complex mainly introduces di-methylation on H3K9 and DNA ligase 1 (LIG1) K126 in cells.	Lysine	136-142	activating transcription factor 7 interacting protein	Homo sapiens	93-99
30286792-4	2018	One of the identified substrates, activating transcriptional factor 7-interacting protein 1 (ATF7IP), is tri-methylated at a histone H3 lysine 9 (H3K9)-like mimic by the G9a/GLP complex, although this complex mainly introduces di-methylation on H3K9 and DNA ligase 1 (LIG1) K126 in cells.	Lysine	136-142	euchromatic histone lysine methyltransferase 2	Homo sapiens	170-173
30286792-5	2018	The catalytic domain of G9a showed a higher affinity for di-methylated lysine on ATF7IP than LIG1, which may create different methylation levels of different substrates in cells.	Lysine	71-77	euchromatic histone lysine methyltransferase 2	Homo sapiens	24-27
30286792-5	2018	The catalytic domain of G9a showed a higher affinity for di-methylated lysine on ATF7IP than LIG1, which may create different methylation levels of different substrates in cells.	Lysine	71-77	activating transcription factor 7 interacting protein	Homo sapiens	81-87
7725796-0	1994	Effect of site-directed mutagenesis of conserved lysine residues upon Pas1 protein function in peroxisome biogenesis.	Lysine	49-55	AAA family ATPase peroxin 1	Saccharomyces cerevisiae S288C	70-74
25865244-1	2015	Deoxyhypusine hydroxylase (DOHH) is a non-heme diiron enzyme involved in the posttranslational modification of a critical lysine residue of eukaryotic translation initiation factor 5A (eIF-5A) to yield the unusual amino acid residue hypusine.	Lysine	122-128	deoxyhypusine hydroxylase	Homo sapiens	0-25
7947827-0	1994	Lysine-heparin interactions in antithrombin.	Lysine	0-6	serpin family C member 1	Homo sapiens	31-43
30286792-9	2018	CONCLUSIONS: Our findings provide new insights into the roles of lysine methylation in non-histone substrates which are targeted by the G9a/GLP complex and suggest a potential function of ATF7IP methylation in SETDB1/MPP8-mediated transgene silencing.	Lysine	65-71	euchromatic histone lysine methyltransferase 2	Homo sapiens	136-139
30286792-9	2018	CONCLUSIONS: Our findings provide new insights into the roles of lysine methylation in non-histone substrates which are targeted by the G9a/GLP complex and suggest a potential function of ATF7IP methylation in SETDB1/MPP8-mediated transgene silencing.	Lysine	65-71	M-phase phosphoprotein 8	Homo sapiens	217-221
30224481-1	2018	The KAT5 (Tip60/Esa1) histone acetyltransferase is part of NuA4, a large multifunctional complex highly conserved from yeast to mammals that targets lysines on H4 and H2A (X/Z) tails for acetylation.	Lysine	149-156	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	4-8
30224481-1	2018	The KAT5 (Tip60/Esa1) histone acetyltransferase is part of NuA4, a large multifunctional complex highly conserved from yeast to mammals that targets lysines on H4 and H2A (X/Z) tails for acetylation.	Lysine	149-156	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	16-20
7947827-2	1994	Lysine residues in two different regions of antithrombin have been proposed to be involved in heparin binding and heparin-mediated acceleration of proteinase inhibition.	Lysine	0-6	serpin family C member 1	Homo sapiens	44-56
25865244-1	2015	Deoxyhypusine hydroxylase (DOHH) is a non-heme diiron enzyme involved in the posttranslational modification of a critical lysine residue of eukaryotic translation initiation factor 5A (eIF-5A) to yield the unusual amino acid residue hypusine.	Lysine	122-128	deoxyhypusine hydroxylase	Homo sapiens	27-31
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 2	Homo sapiens	66-69
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 2	Homo sapiens	71-76
7947717-4	1994	The amino acid sequence of the opsin-related protein in humans is 86% identical to that of bovine RGR, and a lysine residue, analogous to the retinaldehyde attachment site of rhodopsin, is conserved in the seventh transmembrane domain of RGR in both species.	Lysine	109-115	rhodopsin	Bos taurus	175-184
29855824-1	2018	Background Heterodimeric methyltransferases GLP (EHMT1/KMT1D) and G9a (EHMT2/KMT1C) are two closely related enzymes that promote the monomethylation and dimethylation of histone H3 lysine 9.	Lysine	181-187	euchromatic histone lysine methyltransferase 2	Homo sapiens	77-82
25865244-1	2015	Deoxyhypusine hydroxylase (DOHH) is a non-heme diiron enzyme involved in the posttranslational modification of a critical lysine residue of eukaryotic translation initiation factor 5A (eIF-5A) to yield the unusual amino acid residue hypusine.	Lysine	122-128	eukaryotic translation initiation factor 5A	Homo sapiens	140-183
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	4-7	arachidonate 5-lipoxygenase	Mus musculus	31-45
30128637-4	2018	The Lys 131 site of Cotl1, the 5-Lipoxygenase (5LO) binding site, is spatially close to Lys 75, leading to impact the binding of Cotl1 to F-actin.	Lysine	88-91	arachidonate 5-lipoxygenase	Mus musculus	31-45
7947717-4	1994	The amino acid sequence of the opsin-related protein in humans is 86% identical to that of bovine RGR, and a lysine residue, analogous to the retinaldehyde attachment site of rhodopsin, is conserved in the seventh transmembrane domain of RGR in both species.	Lysine	109-115	RGR	Bos taurus	238-241
25865244-1	2015	Deoxyhypusine hydroxylase (DOHH) is a non-heme diiron enzyme involved in the posttranslational modification of a critical lysine residue of eukaryotic translation initiation factor 5A (eIF-5A) to yield the unusual amino acid residue hypusine.	Lysine	122-128	eukaryotic translation initiation factor 5A	Homo sapiens	185-191
30140938-5	2018	Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance.	Lysine	59-65	cAMP responsive element binding protein 1	Homo sapiens	226-230
7713281-0	1994	Lack of in vitro complement activation by the human insulin analogue LYS(b28)PRO(B29)	Lysine	69-72	CD79b molecule	Homo sapiens	81-84
25738370-4	2015	Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32&gt;K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.	Lysine	123-129	glutathione S-transferase zeta 1	Homo sapiens	159-164
30054359-10	2018	The kcat and Km of IpaH against iprodione were 22.42 s-1 and 7.33 muM, respectively, and the catalytic efficiency value (kcat/Km ) was 3.09 muM-1 s-1 IpaH has a Ser-Ser-Lys motif, which is conserved among members of the amidase signature family.	Lysine	169-172	amidase	Bradyrhizobium diazoefficiens USDA 110	220-227
30194291-7	2018	This set of dosage-sensitive genes maintains such regulation during evolution, as MSL2 binds and similarly regulates mouse orthologues via Histone H4 lysine 16 acetylation.	Lysine	150-156	MSL complex subunit 2	Mus musculus	82-86
7523383-7	1994	When the TSAO-specific resistance mutation Glu138--&gt;Lys was introduced solely in the p51 subunit of the RT p66/p51 heterodimer, the enzyme proved completely resistant to TSAO-m3T but retained full sensitivity to TIBO R82150 and ddGTP.	Lysine	55-58	tumor protein p63	Homo sapiens	88-91
25738370-4	2015	Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32&gt;K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.	Lysine	123-129	glutathione S-transferase zeta 1	Homo sapiens	247-252
7523383-7	1994	When the TSAO-specific resistance mutation Glu138--&gt;Lys was introduced solely in the p51 subunit of the RT p66/p51 heterodimer, the enzyme proved completely resistant to TSAO-m3T but retained full sensitivity to TIBO R82150 and ddGTP.	Lysine	55-58	DNA polymerase delta 3, accessory subunit	Homo sapiens	110-113
25738370-6	2015	GSTZ1 expression data were analyzed on the basis of the presence or absence of lysine 32.	Lysine	79-85	glutathione S-transferase zeta 1	Homo sapiens	0-5
7523383-7	1994	When the TSAO-specific resistance mutation Glu138--&gt;Lys was introduced solely in the p51 subunit of the RT p66/p51 heterodimer, the enzyme proved completely resistant to TSAO-m3T but retained full sensitivity to TIBO R82150 and ddGTP.	Lysine	55-58	tumor protein p63	Homo sapiens	114-117
25995743-0	2015	Galactosylated poly-L-lysine targeted microbubbles for ultrasound mediated antisense c-myc gene transfection in hepatocellular carcinoma cells.	Lysine	15-28	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-90
8086440-5	1994	A lysine to glutamic acid substitution in the catalytic domain of RLK5 results in the catalytically inactive protein RLK5(Cat)K711E.	Lysine	2-8	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	66-70
8086440-5	1994	A lysine to glutamic acid substitution in the catalytic domain of RLK5 results in the catalytically inactive protein RLK5(Cat)K711E.	Lysine	2-8	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	117-121
30146412-7	2018	SIRT1 deacetylated TET2 at conserved lysine residues in its catalytic domain, enhancing TET2 activity.	Lysine	37-43	sirtuin 1	Homo sapiens	0-5
29859500-1	2018	OBJECTIVE: To investigate the role of the histone 3 lysine 27 trimethylation (H3K27me3) demethylase Jumonji domain-containing protein 3 (Jmjd3) in the epigenetic regulation of the inflammatory response in human periodontal ligament cells (HPDLs).	Lysine	52-58	lysine demethylase 6B	Homo sapiens	100-135
29859500-1	2018	OBJECTIVE: To investigate the role of the histone 3 lysine 27 trimethylation (H3K27me3) demethylase Jumonji domain-containing protein 3 (Jmjd3) in the epigenetic regulation of the inflammatory response in human periodontal ligament cells (HPDLs).	Lysine	52-58	lysine demethylase 6B	Homo sapiens	137-142
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	TNF receptor associated factor 6	Homo sapiens	280-285
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	Lysine	199-205	lysine demethylase 6B	Homo sapiens	40-45
29859500-7	2018	Moreover, ChIP assays demonstrated that Jmjd3 was recruited to the promoters of interleukin-6 and interleukin-12b and this recruitment was associated with decreased levels of trimethylated histone 3 lysine 27 (H3K27).	Lysine	199-205	interleukin 12B	Homo sapiens	98-113
8062907-2	1994	Acidic and basic fibroblast growth factors also stimulated the phosphorylation of serine and tyrosine of FAK in cells adhered to poly-L-lysine, but epidermal growth factor and platelet-derived growth factor did not.	Lysine	129-142	PTK2 protein tyrosine kinase 2	Mus musculus	105-108
7921620-4	1994	The beta 3-agonists, bucindolol, CGP 12177A and pindolol exhibited the highest binding affinities; BRL 37344, LY 79771, ICI 201651 and SR 58611A presented high potencies in stimulating adenylyl cyclase; bupranolol appeared as the most efficient beta 3-antagonist.	Lysine	110-112	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	4-10
29449643-4	2018	In this work, we studied the functional significance of reversible lysine acetylation in regulating the kinase activity of JNK.	Lysine	67-73	mitogen-activated protein kinase 8	Mus musculus	123-126
25755250-4	2015	We have identified that acetylation occurs at three lysine residues, K159, K185, and K404 (3K), and enhances the association between GOT2 and MDH2.	Lysine	52-58	glutamic-oxaloacetic transaminase 2	Homo sapiens	133-137
25557051-5	2015	The replacement of the Lys or Arg linker with the betaAla or Ahx linker retained nanomolar receptor-binding affinities and remarkable cytotoxicity of RGD-betaAla-(Arg(11))CCMSH and RGD-Ahx-(Arg(11))CCMSH.	Lysine	23-26	nuclear receptor subfamily 0, group B, member 1	Mus musculus	185-188
30173739-4	2018	Next, the amino acids including His-159 in nsp1beta, and His-129, His-144 and Lys-173 in nsp11 were determined to play crucial roles in the reduction of CH25H.	Lysine	78-81	cholesterol 25-hydroxylase	Homo sapiens	153-158
7937474-2	1994	Plasma and egg yolk VLDL were isolated by ultracentrifugation and free epsilon-amino groups of lysines of apolipoprotein B (apo B), the protein constituent of VLDL that mediates binding to the 95-kDa oocyte membrane receptor, were biotinylated using D-biotin-N-hydroxysuccinimide ester.	Lysine	95-102	very low density lipoprotein receptor	Gallus gallus	20-24
7937474-2	1994	Plasma and egg yolk VLDL were isolated by ultracentrifugation and free epsilon-amino groups of lysines of apolipoprotein B (apo B), the protein constituent of VLDL that mediates binding to the 95-kDa oocyte membrane receptor, were biotinylated using D-biotin-N-hydroxysuccinimide ester.	Lysine	95-102	apolipoprotein B	Gallus gallus	106-122
7937474-2	1994	Plasma and egg yolk VLDL were isolated by ultracentrifugation and free epsilon-amino groups of lysines of apolipoprotein B (apo B), the protein constituent of VLDL that mediates binding to the 95-kDa oocyte membrane receptor, were biotinylated using D-biotin-N-hydroxysuccinimide ester.	Lysine	95-102	apolipoprotein B	Gallus gallus	124-129
7937474-2	1994	Plasma and egg yolk VLDL were isolated by ultracentrifugation and free epsilon-amino groups of lysines of apolipoprotein B (apo B), the protein constituent of VLDL that mediates binding to the 95-kDa oocyte membrane receptor, were biotinylated using D-biotin-N-hydroxysuccinimide ester.	Lysine	95-102	very low density lipoprotein receptor	Gallus gallus	159-163
7912928-2	1994	HPLC purified 14C-glucose labeled chymotryptic peptides and affinity chromatography/HPLC purified fully glycated peptides were identified by FAB-MS. Lys 11 and 78 of alpha A-crystallin and Lys 90 and/or 92 of alpha B-crystallin were the fast reacting sites of glucosylation.	Lysine	149-152	FA complementation group B	Homo sapiens	141-144
29950424-6	2018	In this work, we show, using a reconstituted sumoylation system in Escherichia coli, that tomato PCNA is sumoylated at two residues, K254 and K164, and that coexpression of the geminivirus protein Rep suppresses sumoylation at these lysines.	Lysine	233-240	proliferating cell nuclear antigen	Solanum lycopersicum	97-101
25660616-0	2015	The role of lysine(100) in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: implications for other acetyltransferases.	Lysine	12-18	N-acetyltransferase 1	Homo sapiens	68-99
29967243-8	2018	Point mutations within the PBD, including arginine-to-lysine substitutions, profoundly alter Rac1 lipid binding specificity without changing the electrostatics of the protein and result in impaired macropinocytosis and decreased cell spreading.	Lysine	54-60	Rac family small GTPase 1	Homo sapiens	93-97
8069221-9	1994	Electrostatic intermolecular interactions involving the lysine binding site are also found in the crystal structures of PGK1 and orthorhombic PGK4.	Lysine	56-62	phosphoglycerate kinase 1	Homo sapiens	120-124
25660616-3	2015	Here, we have investigated the role of a highly conserved amino acid (Lys(100)) in the enzymatic activity of human NAT1.	Lysine	70-73	N-acetyltransferase 1	Homo sapiens	115-119
30061404-6	2018	In addition, enrichment of histone H3 lysine 4 trimethylation (a mark of gene activation) at the PGC-1alpha locus was markedly reduced in Smyd1-KO mice, and Smyd1-induced transcriptional activation of PGC-1alpha was confirmed by luciferase reporter assays.	Lysine	38-44	SET and MYND domain containing 1	Mus musculus	138-143
25609799-0	2015	The lysine residues within the human ribosomal protein S17 sequence naturally inserted into the viral nonstructural protein of a unique strain of hepatitis E virus are important for enhanced virus replication.	Lysine	4-10	ribosomal protein S17	Homo sapiens	37-58
30165935-14	2018	In the base-case analysis, RMI 1 (threshold of 250) was the least effective [16.926 life-years (LYs), 13.820 QALYs] and the second cheapest ($5669).	Lysine	96-99	RecQ mediated genome instability 1	Homo sapiens	27-32
8004226-3	1994	The effect of cytochrome b5 mutation, by substitution of the glutamic acid at positions 56 and 92 of the polypeptide chain by a lysine, on protein partitioning was also studied.	Lysine	128-134	cytochrome b5 type A	Homo sapiens	14-27
25609799-7	2015	We demonstrate that the RPS17 sequence insertion in HEV bestows novel nuclear/nucleolar trafficking capabilities to the ORF1 protein of Kernow P6 HEV and that lysine residues within the RPS17 insertion, but not nuclear localization of the ORF1 protein, correlate with the enhanced replication of the HEV Kernow C-1 P6 strain.	Lysine	159-165	ribosomal protein S17	Homo sapiens	186-191
25609799-14	2015	We provide evidence that insertion of the RPS17 sequence in HEV likely confers nuclear trafficking capabilities to the nonstructural protein of the virus and that lysine residues within the RPS17 insertion are important for enhanced replication of the virus.	Lysine	163-169	ribosomal protein S17	Homo sapiens	190-195
29602958-8	2018	HDLM-2 derived HLA-G peptides are anchored by an Arg at p1 and K562-derived peptides are anchored by a Lys.	Lysine	103-106	major histocompatibility complex, class I, G	Homo sapiens	15-20
25925379-0	2015	Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.	Lysine	47-53	SET and MYND domain containing 2	Homo sapiens	32-37
29596991-5	2018	In this study, we report that Lysine 86 in IL15 is responsible for the instability in mammalian cells when its C-terminus is fused to the albumin binding scFv (IL15-A10m3).	Lysine	30-36	interleukin 15	Homo sapiens	43-47
29596991-5	2018	In this study, we report that Lysine 86 in IL15 is responsible for the instability in mammalian cells when its C-terminus is fused to the albumin binding scFv (IL15-A10m3).	Lysine	30-36	interleukin 15	Homo sapiens	160-164
8202378-3	1994	Twelve of the fourteen single-point mutations that give rise to temperature-sensitive (ts) or null phenotypes are located in the portion of the PRP4 gene that corresponds to the beta-transducin-like region of the protein; the remaining two are located in the central portion of the gene, one of them in an arginine-lysine-rich region.	Lysine	315-321	U4/U6-U5 snRNP complex subunit PRP4	Saccharomyces cerevisiae S288C	144-148
8022260-7	1994	Introduction of two lysine residues at the carboxy-terminal side of the internal signal sequence reversed the topology of the transmembrane protein by translocating the amino-terminal nuclease domain across the membrane, leaving the carboxyl terminal beta-lactamase domain in the cytoplasm.	Lysine	20-26	nuclease	Escherichia coli	184-192
25925379-0	2015	Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.	Lysine	47-53	phosphatase and tensin homolog	Homo sapiens	69-73
25925379-4	2015	In this study, we demonstrated that the oncogenic protein lysine methyltransferase SET and MYND domain containing 2 (SMYD2) methylates PTEN at lysine 313 in vitro and in vivo.	Lysine	58-64	SET and MYND domain containing 2	Homo sapiens	83-115
25925379-4	2015	In this study, we demonstrated that the oncogenic protein lysine methyltransferase SET and MYND domain containing 2 (SMYD2) methylates PTEN at lysine 313 in vitro and in vivo.	Lysine	58-64	SET and MYND domain containing 2	Homo sapiens	117-122
7906267-0	1994	Mutation of Glu-80--&gt;Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex.	Lysine	24-27	thrombomodulin	Homo sapiens	124-138
29860315-3	2018	The lysine methyltransferases G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha at lysine (K) 674 in vitro and in vivo.	Lysine	4-10	golgin A6 family member A	Homo sapiens	38-41
25925379-4	2015	In this study, we demonstrated that the oncogenic protein lysine methyltransferase SET and MYND domain containing 2 (SMYD2) methylates PTEN at lysine 313 in vitro and in vivo.	Lysine	58-64	phosphatase and tensin homolog	Homo sapiens	135-139
25925379-6	2015	Furthermore, PTEN protein with lysine 313 substitution diminished phosphorylation of PTEN at serine 380, which is known to inactivate tumor suppressor functions of PTEN.	Lysine	31-37	phosphatase and tensin homolog	Homo sapiens	13-17
8159793-4	1994	The second transcript encoded the SbHRGP-2 protein containing the 16-amino acid repeat Ser-Pro4-Ser-Pro-Ser-Pro4-Tyr-Tyr-Tyr-Lys/His.	Lysine	125-128	extensin-2	Glycine max	34-42
25925379-6	2015	Furthermore, PTEN protein with lysine 313 substitution diminished phosphorylation of PTEN at serine 380, which is known to inactivate tumor suppressor functions of PTEN.	Lysine	31-37	phosphatase and tensin homolog	Homo sapiens	85-89
29920096-5	2018	The addition of two or three residues of lysine, in turn, not only improved the peptide"s solubility but also increased the binding affinity for C3b while retaining its inhibitory potency.	Lysine	41-47	complement C3	Homo sapiens	145-148
25925379-6	2015	Furthermore, PTEN protein with lysine 313 substitution diminished phosphorylation of PTEN at serine 380, which is known to inactivate tumor suppressor functions of PTEN.	Lysine	31-37	phosphatase and tensin homolog	Homo sapiens	85-89
25925379-7	2015	Taken together, our findings unveil a novel mechanism of PTEN dysregulation regulated by lysine methylation in human cancer.	Lysine	89-95	phosphatase and tensin homolog	Homo sapiens	57-61
29940121-0	2018	Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach.	Lysine	29-32	X-linked inhibitor of apoptosis	Homo sapiens	42-46
29940121-3	2018	In our implementation, the approach identified a critical Lys residue in the BIR3 domain of XIAP.	Lysine	58-61	X-linked inhibitor of apoptosis	Homo sapiens	92-96
25822547-6	2015	Increased histone H3 lysine 4 tri-methylation (H3K4me3) levels were detected in brm-3, bp-9 and brm-3 bp-9 double mutants.	Lysine	21-27	transcription regulatory protein SNF2	Arabidopsis thaliana	80-83
30022091-4	2018	MDC1 interacts mainly with EHMT1, which is facilitated by DNA damage-initiated ATM signalling, and EHMT2 dominantly modulates methylation of MDC1 lysine 45.	Lysine	146-152	mediator of DNA damage checkpoint 1	Homo sapiens	0-4
30022091-4	2018	MDC1 interacts mainly with EHMT1, which is facilitated by DNA damage-initiated ATM signalling, and EHMT2 dominantly modulates methylation of MDC1 lysine 45.	Lysine	146-152	euchromatic histone lysine methyltransferase 2	Homo sapiens	99-104
30022091-4	2018	MDC1 interacts mainly with EHMT1, which is facilitated by DNA damage-initiated ATM signalling, and EHMT2 dominantly modulates methylation of MDC1 lysine 45.	Lysine	146-152	mediator of DNA damage checkpoint 1	Homo sapiens	141-145
7532018-0	1994	CD5-positive and CD5-negative plaque-forming cells against poly-L-lysine-treated sheep erythrocytes in patients with systemic lupus erythematosus.	Lysine	59-72	T-cell surface glycoprotein CD5	Ovis aries	0-3
7532018-0	1994	CD5-positive and CD5-negative plaque-forming cells against poly-L-lysine-treated sheep erythrocytes in patients with systemic lupus erythematosus.	Lysine	59-72	T-cell surface glycoprotein CD5	Ovis aries	17-20
25822547-6	2015	Increased histone H3 lysine 4 tri-methylation (H3K4me3) levels were detected in brm-3, bp-9 and brm-3 bp-9 double mutants.	Lysine	21-27	transcription regulatory protein SNF2	Arabidopsis thaliana	96-99
30016968-11	2018	Mechanistically, Ube2v1 promoted Ubc13-mediated ubiquitination and degradation of Sirt1 and inhibited histone H4 lysine 16 acetylation, and finally epigenetically suppressed autophagy gene expression in CRC.	Lysine	113-119	ubiquitin-conjugating enzyme E2 variant 1	Mus musculus	17-23
25811481-4	2015	Further, we show that VLCAD binds strongly to cardiolipin and isolated mitochondrial membranes via a domain near the C-terminus containing lysines K482, K492, and K507.	Lysine	139-146	acyl-CoA dehydrogenase very long chain	Homo sapiens	22-27
29961803-2	2018	We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues.	Lysine	93-99	lysine demethylase 6B	Homo sapiens	33-38
29961803-2	2018	We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues.	Lysine	93-99	lysine demethylase 6B	Homo sapiens	40-45
29961803-3	2018	The results unexpectedly reveal that KDM6B accepts multiple Nepsilon-alkylated lysine analogues, forming alcohol, aldehyde and carboxylic acid products.	Lysine	79-85	lysine demethylase 6B	Homo sapiens	37-42
8148817-1	1994	It is known that macrophages recognize and take up oxidized low density lipoprotein (LDL) and this macrophage recognition has been suggested to be due to modification of the lysine (Lys) residues of apoprotein B (apo B).	Lysine	174-180	apolipoprotein B	Mus musculus	199-211
8148817-1	1994	It is known that macrophages recognize and take up oxidized low density lipoprotein (LDL) and this macrophage recognition has been suggested to be due to modification of the lysine (Lys) residues of apoprotein B (apo B).	Lysine	174-180	apolipoprotein B	Mus musculus	213-218
8148817-1	1994	It is known that macrophages recognize and take up oxidized low density lipoprotein (LDL) and this macrophage recognition has been suggested to be due to modification of the lysine (Lys) residues of apoprotein B (apo B).	Lysine	182-185	apolipoprotein B	Mus musculus	199-211
8148817-1	1994	It is known that macrophages recognize and take up oxidized low density lipoprotein (LDL) and this macrophage recognition has been suggested to be due to modification of the lysine (Lys) residues of apoprotein B (apo B).	Lysine	182-185	apolipoprotein B	Mus musculus	213-218
8148817-4	1994	When delipidated apo B, partially methylated at the epsilon-amino groups of Lys residues, was treated with LOOH and octenal, fluorescence was not produced and the free Lys residues were not decreased.	Lysine	76-79	apolipoprotein B	Mus musculus	17-22
8148817-4	1994	When delipidated apo B, partially methylated at the epsilon-amino groups of Lys residues, was treated with LOOH and octenal, fluorescence was not produced and the free Lys residues were not decreased.	Lysine	168-171	apolipoprotein B	Mus musculus	17-22
8148817-8	1994	Neutralization of positively charged Lys residues of apo B by modification with LOOH and octenal may be requisite for recognition.	Lysine	37-40	apolipoprotein B	Mus musculus	53-58
25789466-11	2015	Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12 (H4K12).	Lysine	161-167	histone deacetylase 1 S homeolog	Xenopus laevis	22-27
8250857-8	1993	The sequence was compared with the known MLCK sequence, and the labelled residue was identified as lysine-548, which is located downstream of the GXGXXG motif conserved among ATP-utilizing enzymes.	Lysine	99-105	myosin light chain kinase	Homo sapiens	41-45
8226835-4	1993	However, the relatively short intervening peptide sequence that separates the crucial peptide membrane-binding domain from lysine 41, which has been implicated in the active-site interaction with cytochrome b5 (Strittmatter, P., Kittler, J. M., Coghill, J. E., and Ozols, J.	Lysine	123-129	cytochrome b5 type A	Homo sapiens	196-209
30288233-3	2018	After anchoring to cetuximab through amide bond with lysines, the resulting HDAC inhibitor-antibody conjugates showed ability to recognize EGFR and efficient internalization in tumor cells.	Lysine	53-60	histone deacetylase 9	Homo sapiens	76-80
29942010-6	2018	Conversely, upon glucose starvation, SRSF5 is deacetylated by HDAC1, and ubiquitylated by Smurf1 on the same lysine, resulting in proteasomal degradation of SRSF5.	Lysine	109-115	serine and arginine rich splicing factor 5	Homo sapiens	37-42
29942033-3	2018	Here, we describe a proteomics approach facilitating system-wide and in vivo identification of lysines modified by endogenous and native SUMO2.	Lysine	95-102	small ubiquitin like modifier 2	Homo sapiens	137-142
25789466-11	2015	Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12 (H4K12).	Lysine	161-167	histone deacetylase 1 S homeolog	Xenopus laevis	45-50
29920217-5	2018	The DUSP14 triple-methylation mutant was impaired in PRMT5-mediated arginine methylation, TRAF2-mediated lysine ubiquitination, and DUSP14 phosphatase activity.	Lysine	105-111	TNF receptor associated factor 2	Homo sapiens	90-95
8255775-4	1993	We show that a restricted selectivity for GGAA core-containing sites could be conferred to Ets1 upon changing a single lysine residue within CRIII to the threonine found in Elf1 and E74 at this position.	Lysine	119-125	ETS proto-oncogene 1, transcription factor	Homo sapiens	91-95
25614281-5	2015	We focused on miR-101 and 1 of its targets, enhancer of zester homolog-2 (EZH2), which trimethylates the lysine 27 of histone 3, thus repressing gene transcription.	Lysine	105-111	fibronectin type III and SPRY domain containing 1	Homo sapiens	14-27
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Lysine	47-50	C-C motif chemokine ligand 14	Homo sapiens	102-106
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Lysine	65-68	C-C motif chemokine ligand 14	Homo sapiens	102-106
29678583-2	2018	Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENP1.	Lysine	52-58	PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1	Homo sapiens	23-30
25583990-1	2015	SET and MYND domain-containing 2 (Smyd2), a histone 3 lysine 4- and histone 3 lysine 36 (H3K36)-specific methyltransferase, plays critical roles in cardiac development and tumorigenesis.	Lysine	54-60	SET and MYND domain containing 2	Homo sapiens	34-39
29930510-8	2018	In both CCI-SN and CCI-ION models, suppression of mechanical allodynia by "agomelatine + gabapentin" could be partially mimicked by the combination of 5-HT2C antagonist (SB 242084) + gabapentin, but not by melatonin or 5-HT2B antagonist (RS 127445, LY 266097), alone or combined with gabapentin.	Lysine	249-251	5-hydroxytryptamine receptor 2C	Rattus norvegicus	151-157
25583990-1	2015	SET and MYND domain-containing 2 (Smyd2), a histone 3 lysine 4- and histone 3 lysine 36 (H3K36)-specific methyltransferase, plays critical roles in cardiac development and tumorigenesis.	Lysine	78-84	SET and MYND domain containing 2	Homo sapiens	34-39
29588287-1	2018	The histone demethylase LSD1 was originally discovered by removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1).	Lysine	120-126	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	24-28
24190710-3	1993	Differently to the reactivity usually described on the basis of other analytical techniques, FAB mass spectrometric measurements indicate the occurrence of the reaction of protected lysine with more than one D-glucose molecule.	Lysine	182-188	FA complementation group B	Homo sapiens	93-96
25660273-2	2015	CBX7 functions through its N-terminal chromodomain (ChD), which recognizes trimethylated lysine 27 of histone 3 (H3K27me3), a conserved epigenetic mark that signifies gene transcriptional repression.	Lysine	89-95	chromobox 7	Homo sapiens	0-4
8376387-4	1993	NH2-terminal sequence analysis indicated that all three forms were cleaved following the sequence -Arg107-Arg-Lys-Arg110, indicating removal of an SPC3 prosequence.	Lysine	110-113	proprotein convertase subtilisin/kexin type 1	Homo sapiens	147-151
25563699-2	2015	We introduce a model that connects the presence of epigenetically inherited histone marks, methylation at histone 3 lysine-9, to the physical compaction of chromatin fibers via the binding of heterochromatin protein 1 (HP1).	Lysine	116-122	chromobox 5	Homo sapiens	192-217
8307787-5	1993	Negativity for the NK-1 specificity corresponded to the presence of asparagine and lysine at positions 77 and 80, respectively, in the second exon of HLA-C (alleles Cw2, 4, 5, and 6), while negativity for the NK-2 group corresponded to the presence of serine and asparagine, respectively, at these two positions (alleles Cw1, 3, 7, and 8).	Lysine	83-89	tachykinin receptor 1	Homo sapiens	19-23
29659022-4	2018	RD26 also directly activates LKR/SDH involved in lysine catabolism, and PES1 important for phytol degradation.	Lysine	49-55	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	0-4
29659022-4	2018	RD26 also directly activates LKR/SDH involved in lysine catabolism, and PES1 important for phytol degradation.	Lysine	49-55	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	29-36
25563699-2	2015	We introduce a model that connects the presence of epigenetically inherited histone marks, methylation at histone 3 lysine-9, to the physical compaction of chromatin fibers via the binding of heterochromatin protein 1 (HP1).	Lysine	116-122	chromobox 5	Homo sapiens	219-222
25448846-3	2015	Site-directed mutations revealed that CIS can be ubiquitinated on all six lysine residues.	Lysine	74-80	cytokine inducible SH2 containing protein	Homo sapiens	38-41
29805595-1	2018	G9A, the primary histone methyltransferase (HMTase) for histone H3 lysine 9, is upregulated in numerous types of cancer and is critical for tumor cell proliferation.	Lysine	67-73	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
29770822-3	2018	The smart size-switchable nanoplatform (DGL/DOX@PP) was prepared by conjugating small dendrigraft poly-l-lysine (DGL) to poly(ethylene glycol)-poly(caprolactone) micelles via a matrix metalloproteinase 2 (MMP-2)-sensitive peptide.	Lysine	98-111	matrix metallopeptidase 2	Mus musculus	177-203
29770822-3	2018	The smart size-switchable nanoplatform (DGL/DOX@PP) was prepared by conjugating small dendrigraft poly-l-lysine (DGL) to poly(ethylene glycol)-poly(caprolactone) micelles via a matrix metalloproteinase 2 (MMP-2)-sensitive peptide.	Lysine	98-111	matrix metallopeptidase 2	Mus musculus	205-210
8346241-0	1993	The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.	Lysine	73-80	interleukin 1 alpha	Homo sapiens	24-43
8346241-4	1993	We report that the N terminus of the 31-kDa IL-1 alpha precursor is myristoylated on specific internal lysine residues.	Lysine	103-109	interleukin 1 alpha	Homo sapiens	44-54
25448846-5	2015	CIS stability was increased by mutation of lysine residues and further enhanced by co-mutation of Elongin B/C interaction domain.	Lysine	43-49	cytokine inducible SH2 containing protein	Homo sapiens	0-3
8314769-3	1993	One of its lysine residues is post-translationally modified by spermidine to form hypusine, a unique residue required for eIF-5A activity.	Lysine	11-17	eukaryotic translation initiation factor 5A	Homo sapiens	122-128
25326673-6	2015	Knockdown of steroid receptor coactivator 1, a member of histone acetyltransferases, but not general control of amino acid synthesis 5 nor elongator protein 3 by in vivo electroporation of shRNA plasmids, reduced acetylated histone H3 at lysine 9 in round spermatids, and induced morphological abnormalities.	Lysine	238-244	nuclear receptor coactivator 1	Mus musculus	13-43
7686371-0	1993	Rheumatoid factors from patients with rheumatoid arthritis react with tryptophan 60 and 95, lysine 58, and arginine 97, on human beta 2-microglobulin.	Lysine	92-98	beta-2-microglobulin	Homo sapiens	129-149
29807539-3	2018	RESULTS: We show that H3 monomethylation at lysine 27 (H3K27me1) is essential for MMP-9-dependent H3NT proteolysis during RANKL-induced osteoclast differentiation.	Lysine	44-50	matrix metallopeptidase 9	Homo sapiens	82-87
29807539-3	2018	RESULTS: We show that H3 monomethylation at lysine 27 (H3K27me1) is essential for MMP-9-dependent H3NT proteolysis during RANKL-induced osteoclast differentiation.	Lysine	44-50	TNF superfamily member 11	Homo sapiens	122-127
29658704-2	2018	Here, we report the discovery of a class of bioreactive compounds that covalently modify lysine residues in DegS, the rate limiting protease of the essential bacterial outer membrane stress response pathway.	Lysine	89-95	delta 4-desaturase, sphingolipid 1	Homo sapiens	108-112
7686371-4	1993	RESULTS AND CONCLUSION: Major beta 2m residues contributing to RF reactivity were tryptophans at positions 60 and 95, lysine at 58, and arginine at position 97.	Lysine	118-124	beta-2-microglobulin	Homo sapiens	30-37
25569455-4	2015	Herein we demonstrate that p30(II) induces lysine-acetylation of the c-MYC oncoprotein.	Lysine	43-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
29775417-1	2018	Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
29775417-1	2018	Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types.	Lysine	82-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
29734782-1	2018	Lysine-specific demethylase 1 (LSD1) mainly removes methyl groups of mono- or di-methylated lysine residues at the fourth position of histone H3 to epigenetically regulate the expression of genes associated with several diseases, such as cancer.	Lysine	92-98	lysine demethylase 1A	Homo sapiens	0-29
29734782-1	2018	Lysine-specific demethylase 1 (LSD1) mainly removes methyl groups of mono- or di-methylated lysine residues at the fourth position of histone H3 to epigenetically regulate the expression of genes associated with several diseases, such as cancer.	Lysine	92-98	lysine demethylase 1A	Homo sapiens	31-35
8512563-1	1993	The novel protein kinase PK40 (1) was characterized by its ability to phosphorylate Lys-Ser-Pro sites in neurofilament and TAU proteins.	Lysine	84-87	microtubule associated protein tau	Homo sapiens	123-126
25331950-6	2015	This leads to a dramatic decrease in the repressive lysine 27 trimethylation mark on histone H3 that silences beta-catenin gene expression.	Lysine	52-58	catenin beta 1	Homo sapiens	110-122
29499325-7	2018	In addition, YAP recruits polycomb repressive complex 2 (PRC2) to tri-methylate histone H3 lysine 27 in the promoter region of GDF15.	Lysine	91-97	growth differentiation factor 15	Homo sapiens	127-132
29706618-5	2018	We identified ZFP91 as the E3 ubiquitin ligase that is responsible for hnRNP F ubiquitination at Lys 185 and proteasomal degradation.	Lysine	97-100	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase	Homo sapiens	14-19
8398833-3	1993	A hydrophilic cluster of many Arg and Lys residues, found adjacent to the active site cleft, is proposed to be involved in thrombomodulin and/or protein S interactions.	Lysine	38-41	thrombomodulin	Homo sapiens	123-137
25391650-0	2015	Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9.	Lysine	37-43	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	158-177
25531508-6	2015	On the other hand, the Lyk mutation prevented severe formation of an ADP inhibited state observed for a lysine mutant and even improved the avoidance of inhibition compared with the wild-type F1.	Lysine	104-110	IL2 inducible T cell kinase	Homo sapiens	23-26
7690980-1	1993	The insertion of two lysine residues (cleavage sites of cathepsin B) at the boundary of a peptide recognized by B cells (BD) and a class-II- presentable sequence (TDh) enhanced the anti-BD antibody induction capacity of this type of peptide construct, as well as production of IL2.	Lysine	21-27	L-threonine dehydrogenase (pseudogene)	Homo sapiens	163-166
7690980-2	1993	It is postulated that these lysines generate a neoprocessable site which helps in release of the TDh moiety from the construct, enabling its presentation to class II molecules, an essential step in clonal expansion of the antibody-producing B cell after internalization of the construct via the BD moiety.	Lysine	28-35	L-threonine dehydrogenase (pseudogene)	Homo sapiens	97-100
29514927-8	2018	Moreover, our results indicate that RNF5 autoubiquitination on multiple lysine residues targets it for ubiquitin and VCP--dependent clearance.	Lysine	72-78	ring finger protein 5	Homo sapiens	36-40
29606589-1	2018	The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2, Suz12, and Eed, and it mediates all di- and tri-methylation of histone H3 at lysine 27 in higher eukaryotes.	Lysine	158-164	embryonic ectoderm development	Homo sapiens	92-95
25604483-4	2015	First, we show, by in vitro kinase assays, that previously identified non-S/T-P motifs all harbour one or more C-terminal Arg/Lys residues essential for their phosphorylation by Cdk1.	Lysine	126-129	cyclin dependent kinase 1	Homo sapiens	178-182
29674659-1	2018	In acute cold stress in mammals, JMJD1A, a histone H3 lysine 9 (H3K9) demethylase, upregulates thermogenic gene expressions through beta-adrenergic signaling in brown adipose tissue (BAT).	Lysine	54-60	lysine demethylase 3A	Homo sapiens	33-39
8385121-1	1993	A molecule of myosin subfragment 1 (S1) from skeletal muscle has one reactive lysine residue (RLR) that is rapidly and stoichiometrically modified by trinitrobenzene sulfonate (TNBS).	Lysine	78-84	myosin heavy chain 14	Homo sapiens	14-20
8383674-8	1993	Fab fragments of monoclonal antibodies specific for adducts of oxidation products with lysine prevented the uptake of oxidation product-modified LDL and oxidized LDL by macrophages.	Lysine	87-93	FA complementation group B	Homo sapiens	0-3
25604483-5	2015	Second, using Arg/Lys-scanning oriented peptide libraries, we demonstrate that Cdk1 phosphorylates a minimal sequence S/T-X-X-R/K and more favorable sequences (P)-X-S/T-X-[R/K](2-5) as its non-S/T-P consensus motifs.	Lysine	18-21	cyclin dependent kinase 1	Homo sapiens	79-83
7679216-8	1993	Covalent cross-linking of the oxidized ligand to L-selectin can be demonstrated, suggesting Schiff base formation between lysine residues of the selectin and the newly formed aldehydes.	Lysine	122-128	selectin L	Homo sapiens	49-59
29540553-7	2018	These findings suggest the functional importance of SIRT1 in regulating pathogenic tau acetylation and in suppressing the spread of tau pathology in vivoSIGNIFICANCE STATEMENT In neurodegenerative disorders with inclusions of microtubule-associated protein tau, aberrant lysine acetylation of tau plays critical roles in promoting tau accumulation and toxicity.	Lysine	271-277	microtubule-associated protein tau	Mus musculus	226-260
25416785-0	2015	Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.	Lysine	145-151	Parkinsonism associated deglycase	Homo sapiens	32-36
29244146-2	2018	It is caused by heterozygous mutations in enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for histone H3 at lysine 27 (H3K27) trimethylation.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	42-69
8457538-1	1993	Lack of sufficient methionine and lysine delivered post-ruminally may limit milk production response to bovine somatotropin (bST).	Lysine	34-40	somatotropin	Bos taurus	111-123
25416785-0	2015	Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.	Lysine	145-151	Parkinsonism associated deglycase	Homo sapiens	37-42
1360148-2	1992	Fusion activity requires proteolytic cleavage of the gp160 protein into gp120 and gp41 at a site containing several arginine and lysine residues.	Lysine	129-135	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	72-77
29244146-2	2018	It is caused by heterozygous mutations in enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for histone H3 at lysine 27 (H3K27) trimethylation.	Lysine	136-142	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	71-75
25416785-4	2015	DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum albumin, glyceraldehyde-3-phosphate dehydrogenase, aldolase, and aspartate aminotransferase and thus reactivates these proteins.	Lysine	42-49	Parkinsonism associated deglycase	Homo sapiens	0-4
26112741-2	2015	SPAK and OSR1 are both regulated by WNK (with-no-K(Lys)) kinases.	Lysine	51-54	serine/threonine kinase 39	Mus musculus	0-4
29393489-1	2018	Lysyl oxidase (LOX) is an enzyme that oxidizes lysine residues in collagens and elastin.	Lysine	47-53	lysyl oxidase	Homo sapiens	0-13
29393489-1	2018	Lysyl oxidase (LOX) is an enzyme that oxidizes lysine residues in collagens and elastin.	Lysine	47-53	lysyl oxidase	Homo sapiens	15-18
29393489-1	2018	Lysyl oxidase (LOX) is an enzyme that oxidizes lysine residues in collagens and elastin.	Lysine	47-53	elastin	Homo sapiens	80-87
16653076-4	1992	One sequence, which is lysine rich, occurs in COR47 (the polypeptide encoded by Arabidopsis cor47) and group II LEA proteins, polypeptides hypothesized to have roles in desiccation and drought tolerance (J. Baker, C. Steele, L. Dure III [1988] Plant Mol Biol 11: 277-291).	Lysine	23-29	cold-regulated 47	Arabidopsis thaliana	46-51
16653076-4	1992	One sequence, which is lysine rich, occurs in COR47 (the polypeptide encoded by Arabidopsis cor47) and group II LEA proteins, polypeptides hypothesized to have roles in desiccation and drought tolerance (J. Baker, C. Steele, L. Dure III [1988] Plant Mol Biol 11: 277-291).	Lysine	23-29	cold-regulated 47	Arabidopsis thaliana	92-97
29440709-6	2018	We demonstrated that lysine 830 of BRCA1 is a preferential acetylation site by pCAF and tested its function in embryonic stem (ES) cells by changing lysine 830 to arginine using a transcription activator-like effector nuclease (TALEN) system.	Lysine	21-27	BRCA1 DNA repair associated	Homo sapiens	35-40
25550437-6	2015	Furthermore, we demonstrated that NFATc2 binding is required to induce the histone 3 lysine 4 trimethylation (H3K4me3) epigenetic mark, which is associated with enhanced gene expression.	Lysine	85-91	nuclear factor of activated T cells 2	Homo sapiens	34-40
29440709-10	2018	These data suggest that acetylation of BRCA1 on lysine 830 activates BRCA1 function at the intra-S checkpoint after DNA damage.	Lysine	48-54	BRCA1 DNA repair associated	Homo sapiens	39-44
29440709-10	2018	These data suggest that acetylation of BRCA1 on lysine 830 activates BRCA1 function at the intra-S checkpoint after DNA damage.	Lysine	48-54	BRCA1 DNA repair associated	Homo sapiens	69-74
25035152-8	2015	Post-translational histone methylation at different histone 3 lysine residues was also observed to control the expression of genes related to AH as lysine-specific demethylase-1(LSD1), HSD11B2, and epithelial sodium channel subunit alpha (SCNN1A).	Lysine	62-68	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	185-192
29590613-3	2018	A recent study reports that polyP can be non-enzymatically and covalently attached to lysine residues on yeast proteins Nsr1 and Top1.	Lysine	86-92	Nsr1p	Saccharomyces cerevisiae S288C	120-124
29636708-4	2018	The expression of serum BDNF was detected by enzyme-linked immunosorbent assay (ELISA), the hippocampal BDNF, acetylation levels in histone H3 lysine 9 (acH3K9), and HDAC2 by Western blot, the hippocampal mRNA of BDNF by RT-polymerase chain reaction (PCR).	Lysine	143-149	brain-derived neurotrophic factor	Rattus norvegicus	24-28
1505029-2	1992	The mutation gcd5-1 changes a conserved residue in the putative lysine-binding domain of LysRS.	Lysine	64-70	lysine--tRNA ligase KRS1	Saccharomyces cerevisiae S288C	13-17
25325399-1	2014	Growth hormone releasing peptide, GHRP-6, a hexapeptide (His-(D-Trp)-Ala-Trp-(D-Phe)-Lys-NH2, MW = 872.44 Da) that belongs to a class of synthetic growth hormone secretagogues, can stimulate growth hormone secretion from somatotrophs in several species including humans.	Lysine	85-88	ghrelin and obestatin prepropeptide	Homo sapiens	0-32
1321147-2	1992	Ubiquitin-conjugating enzyme E2(25K) utilizes isolated ubiquitin as the substrate for synthesis of such chains, in which successive ubiquitin units are linked by isopeptide bonds involving the side chain of Lys-48 of one ubiquitin and the COOH group of Gly-76 of the next.	Lysine	207-210	ubiquitin conjugating enzyme E2 K	Homo sapiens	0-35
1364150-4	1992	Our results suggest that homocysteine alters the structure of Lp(a) to expose lysine-binding sites on the apolipoprotein(a) portion of the molecule, and thus provide a potential biochemical link between thrombosis and atherogenesis.	Lysine	78-84	plasminogen	Bos taurus	62-67
29459279-2	2018	Over-expression of LSD1 decreases methylation at histone 3 lysine 4, and aberrantly silences tumor suppressor genes.	Lysine	59-65	lysine demethylase 1A	Homo sapiens	19-23
29414790-10	2018	Mechanistically, KAT7 participates in VEGFR-2 transcription by mediating RNA polymerase II binding, H3 lysine 14, and H4 acetylation in its intragenic region.	Lysine	103-109	kinase insert domain receptor	Homo sapiens	38-45
25446118-4	2014	Efm5 is required for trimethylation of Lys-79 on EF1A.	Lysine	39-42	protein-lysine N-methyltransferase	Saccharomyces cerevisiae S288C	0-4
29363575-2	2018	Here, we report that a Darier disease (DD) mutation of SERCA2b that changes a glutamate to a lysine in the cytoplasmic loop between TM8 and TM9 (E917K) relieves these kinetic constraints.	Lysine	93-99	tetraspanin 16	Homo sapiens	132-135
1612770-2	1992	Data on partial characterization of GP110 suggest that it is a glycoprotein which is enriched in Lys, Glu, His, Leu, and Ala residues.	Lysine	97-100	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	36-41
25152374-3	2014	Building on the previously observed interaction between SIPL1 and PTEN, we report here that SIPL1 promotes PTEN polyubiquitination via lysine 48 (K48)-independent polyubiquitin chains.	Lysine	135-141	phosphatase and tensin homolog	Homo sapiens	66-70
1619028-7	1992	Both 46,XX males contained SRY, whereas one of the 46,XY females had suffered a point mutation in SRY changing a codon for lysine to a stop codon.	Lysine	123-129	sex determining region Y	Homo sapiens	98-101
29564021-7	2018	A decrease of tri-methylated histone H3 lysine 27 (H3K27Me3) in the coding region of p16(INK4a) was observed.	Lysine	40-46	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	85-88
25152374-3	2014	Building on the previously observed interaction between SIPL1 and PTEN, we report here that SIPL1 promotes PTEN polyubiquitination via lysine 48 (K48)-independent polyubiquitin chains.	Lysine	135-141	phosphatase and tensin homolog	Homo sapiens	107-111
25201136-1	2014	Heterochromatin protein 1 (HP1) is an epigenetic modifier of gene regulation and chromatin packing via binding to trimethylated histone H3 lysine 9 (H3K9).	Lysine	139-145	chromobox 5	Homo sapiens	0-25
29453984-5	2018	The major acetylated site of GATA3 in lung adenocarcinoma cells was determined at lysine 119 (AcK119).	Lysine	82-88	GATA binding protein 3	Homo sapiens	29-34
29453984-7	2018	Taken together, we demonstrated that GATA3 acetylation at lysine 119 by CBP hinders the migration and invasion of lung adenocarcinoma cells.	Lysine	58-64	GATA binding protein 3	Homo sapiens	37-42
1394685-0	1992	Application of poly-L-lysine to purification of leukocyte cathepsin G by affinity chromatography.	Lysine	15-28	cathepsin G	Homo sapiens	58-69
1394685-1	1992	Poly-L-lysine with molecular masses of 3.3-290 kDa increased the amidolytic activities of leukocyte elastase and cathepsin G at low concentration, but had little effect on the activities of pancreatic elastase, alpha-chymotrypsin, plasmin and thrombin.	Lysine	0-13	cathepsin G	Homo sapiens	113-124
1394685-2	1992	Highly purified cathepsin G was obtained from column of EAH Sepharose 4B or Suc-L-Tyr-D-Leu-D-Val-pNA-Sepharose (affinity chromatography) by elution with poly-L-lysine solution (0.4 mg/ml, molecular weight (MW.)	Lysine	154-167	cathepsin G	Homo sapiens	16-27
25201136-1	2014	Heterochromatin protein 1 (HP1) is an epigenetic modifier of gene regulation and chromatin packing via binding to trimethylated histone H3 lysine 9 (H3K9).	Lysine	139-145	chromobox 5	Homo sapiens	27-30
25384215-2	2014	Here, we determined that ALDH1A1 activity is inhibited by acetylation of lysine 353 (K353) and that acetyltransferase P300/CBP-associated factor (PCAF) and deacetylase sirtuin 2 (SIRT2) are responsible for regulating the acetylation state of ALDH1A1 K353.	Lysine	73-79	aldehyde dehydrogenase 1 family member A1	Homo sapiens	25-32
1577739-4	1992	S6 kinase II phosphorylated at least four sites (serines 1-3 and 5) in the sequence Arg-Arg-Leu-Ser(1)-Ser(2)-Leu-Arg-Ala-Ser(3)-Thr-Ser(4)-Lys-Ser(5)-, which correspond to the residues known to be phosphorylated in the carboxyl-terminal region of mammalian S6.	Lysine	140-143	ribosomal protein S6 kinase A6 S homeolog	Xenopus laevis	0-12
29466371-7	2018	We inactivated Ezh2 in differentiating embryonic cardiomyocytes, which led to depletion of histone H3 trimethylated at lysine 27 (H3K27me3).	Lysine	119-125	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	15-19
29432156-8	2018	The extent of BubR1 ubiquitylation was markedly increased in recombinant MCC that contained a lysine-less mutant of Cdc20.	Lysine	94-100	cell division cycle 20	Homo sapiens	116-121
29432156-9	2018	Mutation of lysine residues to arginines in the N-terminal region of BubR1 partially inhibited its ubiquitylation and slowed down the release of MCC from APC/C, provided that Cdc20 ubiquitylation was also blocked.	Lysine	12-18	cell division cycle 20	Homo sapiens	175-180
25384215-2	2014	Here, we determined that ALDH1A1 activity is inhibited by acetylation of lysine 353 (K353) and that acetyltransferase P300/CBP-associated factor (PCAF) and deacetylase sirtuin 2 (SIRT2) are responsible for regulating the acetylation state of ALDH1A1 K353.	Lysine	73-79	sirtuin 2	Homo sapiens	179-184
29237037-6	2018	Moreover, we unravel a conserved RNA-dependent regulation of the Rio ATPases, which in the case of Rio2 involves, at least, helix 30 of the SSU rRNA and the P-loop lysine within the shared RIO domain.	Lysine	164-170	RIO kinase 2	Homo sapiens	99-103
25384215-2	2014	Here, we determined that ALDH1A1 activity is inhibited by acetylation of lysine 353 (K353) and that acetyltransferase P300/CBP-associated factor (PCAF) and deacetylase sirtuin 2 (SIRT2) are responsible for regulating the acetylation state of ALDH1A1 K353.	Lysine	73-79	aldehyde dehydrogenase 1 family member A1	Homo sapiens	242-249
25378304-1	2014	The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3).	Lysine	20-26	methyl-CpG binding domain protein 2	Homo sapiens	27-38
29294086-1	2018	Methylation of histone H3 lysine 36 (H3K36me) by yeast Set2 is critical for the maintenance of chromatin structure and transcriptional fidelity.	Lysine	26-32	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	55-59
29415998-4	2018	Further study showed that CFTR expression is regulated by the interaction of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2), which, respectively, regulate DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	cystic fibrosis transmembrane conductance regulator	Mus musculus	26-30
29415998-4	2018	Further study showed that CFTR expression is regulated by the interaction of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2), which, respectively, regulate DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	113-140
1304366-6	1992	Reaction of enzyme in the presence of substrate (showing no activity loss) yielded a single peptide, Asn-Ile-X1-Lys, where X1 corresponds to Cys164 of the known amino acid sequence of muscle pyruvate kinase.	Lysine	112-115	pyruvate kinase PKLR	Oryctolagus cuniculus	191-206
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Lysine	42-45	cyclin dependent kinase 1	Homo sapiens	142-146
29415998-4	2018	Further study showed that CFTR expression is regulated by the interaction of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2), which, respectively, regulate DNA methylation and histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	210-216	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	142-146
25332400-1	2014	Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds to lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin.	Lysine	97-103	chromobox 5	Homo sapiens	0-25
1312009-1	1992	A soluble construct consisting of a plasmid carrying the gene of the SV40 large T-antigen and an insulin-poly-L-lysine conjugate is able to selectively transfect PLC/PRF/5 human hepatoma cells which possess insulin receptors.	Lysine	105-118	heparan sulfate proteoglycan 2	Homo sapiens	162-165
25332400-1	2014	Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds to lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin.	Lysine	97-103	chromobox 5	Homo sapiens	27-30
29212818-2	2018	In this study, we show that the lysine 4 of histone H3 (H3K4), lysine-specific demethylase 5A (KDM5A) is essential for the repression of astrocyte differentiation in neural progenitor cells (NPCs), and its expression is regulated by translational machinery.	Lysine	32-38	lysine demethylase 5A	Homo sapiens	63-93
29212818-2	2018	In this study, we show that the lysine 4 of histone H3 (H3K4), lysine-specific demethylase 5A (KDM5A) is essential for the repression of astrocyte differentiation in neural progenitor cells (NPCs), and its expression is regulated by translational machinery.	Lysine	32-38	lysine demethylase 5A	Homo sapiens	95-100
1536576-4	1992	Isoelectric focusing and amino acid analysis of the differently loaded ferritins showed that ferrous ammonium sulfate loading of apoferritin resulted in the depletion of the basic amino acids, lysine and histidine, probably as a result of protein oxidation.	Lysine	193-199	ferritin heavy chain 1	Homo sapiens	129-140
25248746-0	2014	Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.	Lysine	50-56	adenosylhomocysteinase	Homo sapiens	14-46
16668753-1	1992	Dihydrodipicolinate synthase (EC 4.2.1.52), the first enzyme unique to lysine biosynthesis in bacteria and higher plants, has been purified to homogeneity from etiolated pea (Pisum sativum) seedlings using a combination of conventional and affinity chromatographic steps.	Lysine	71-77	dihydrodipicolinate synthase	Escherichia coli	0-28
16668753-9	1992	The inhibition by l-lysine and l-alpha-(2-aminoethoxyvinyl)glycine is noncompetitive towards l-aspartate-beta-semialdehyde, whereas S-(2-aminoethyl)-l-cysteine inhibits dihydrodipicolinate synthase competitively with respect to l-aspartate-beta-semialdehyde.	Lysine	18-26	dihydrodipicolinate synthase	Escherichia coli	169-197
1545783-1	1992	The very lysine-rich replacement histone variant H1(0) is found to be present in different murine (C1003, PC13, P19) and human (Tera-2) embryonal carcinoma cell lines.	Lysine	9-15	histocompatibility 10	Mus musculus	49-54
29133140-1	2018	The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark.	Lysine	79-85	euchromatic histone lysine methyltransferase 2	Homo sapiens	30-33
29133140-1	2018	The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark.	Lysine	79-85	euchromatic histone lysine methyltransferase 2	Homo sapiens	35-40
25248746-3	2014	Prior proteomics studies have identified two SAHH acetylation sites at Lys(401) and Lys(408) but the impact of these post-translational modifications has not yet been determined.	Lysine	71-74	adenosylhomocysteinase	Homo sapiens	45-49
29288200-4	2018	In the absence of EZH2, genes that normally gained histone H3 lysine 27 trimethylation were dysregulated and exhibited increased chromatin accessibility.	Lysine	62-68	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	18-22
1309759-10	1992	Rather, the presence of a pair of lysines (Lys4-Lys5) within the relatively unstructured N-terminal extension of the yeast cytochromes c may be responsible for their preferential ubiquitination.	Lysine	34-41	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	43-47
25248746-4	2014	Here we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) and show that modification of either position negatively impacts the catalytic activity of SAHH.	Lysine	83-86	adenosylhomocysteinase	Homo sapiens	64-68
29364879-8	2018	Mitochondrial ribosome profiling in SHMT2-knockout human cells reveals that the lack of this modified base causes defective translation, with preferential mitochondrial ribosome stalling at certain lysine (AAG) and leucine (UUG) codons.	Lysine	198-204	serine hydroxymethyltransferase 2	Homo sapiens	36-41
25248746-4	2014	Here we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) and show that modification of either position negatively impacts the catalytic activity of SAHH.	Lysine	83-86	adenosylhomocysteinase	Homo sapiens	196-200
25248746-4	2014	Here we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) and show that modification of either position negatively impacts the catalytic activity of SAHH.	Lysine	96-99	adenosylhomocysteinase	Homo sapiens	64-68
25248746-4	2014	Here we use expressed protein ligation to produce semisynthetic SAHH acetylated at Lys(401) and Lys(408) and show that modification of either position negatively impacts the catalytic activity of SAHH.	Lysine	96-99	adenosylhomocysteinase	Homo sapiens	196-200
29127553-1	2018	Lysyl oxidase (LOX) is a copper-dependent amine oxidase enzyme that catalyzes the formation of crosslinkages of collagen and elastin in connective tissues by oxidative deamination of lysine.	Lysine	183-189	lysyl oxidase	Homo sapiens	0-13
25369635-5	2014	We found that Sirt1, Sirt2, and Sirt3 can catalyze the hydrolysis of lysine crotonylated histone peptides and proteins.	Lysine	69-75	sirtuin 2	Homo sapiens	21-26
29127553-1	2018	Lysyl oxidase (LOX) is a copper-dependent amine oxidase enzyme that catalyzes the formation of crosslinkages of collagen and elastin in connective tissues by oxidative deamination of lysine.	Lysine	183-189	lysyl oxidase	Homo sapiens	15-18
29127553-1	2018	Lysyl oxidase (LOX) is a copper-dependent amine oxidase enzyme that catalyzes the formation of crosslinkages of collagen and elastin in connective tissues by oxidative deamination of lysine.	Lysine	183-189	elastin	Homo sapiens	125-132
1939196-6	1991	Compared to normal tau, the soluble PHF-tau contained 100% more glycine and 35% less lysine residue.	Lysine	85-91	microtubule associated protein tau	Homo sapiens	36-43
24875254-9	2014	Set7-dependent gene expression changes that occurred independent of H3K4m1 may involve transcription factor lysine methylation events.	Lysine	108-114	KMT5A pseudogene 1	Homo sapiens	0-4
1654551-5	1991	This was accomplished using DMc radiolabeled across its entire length by reductive methylation of its lysine residues, allowing an analysis of the totality of processed antigen bound to MHC class II molecules.	Lysine	102-108	Lamin C	Drosophila melanogaster	28-31
29371665-4	2018	Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 directly regulates key myogenic transcription factor genes.	Lysine	38-44	lysine demethylase 1A	Homo sapiens	69-74
29371665-4	2018	Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 directly regulates key myogenic transcription factor genes.	Lysine	38-44	lysine demethylase 1A	Homo sapiens	90-94
29371665-4	2018	Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 directly regulates key myogenic transcription factor genes.	Lysine	38-44	lysine demethylase 1A	Homo sapiens	177-181
1714377-3	1991	In addition to the previously identified c-kit gene product (Kit+), a second normal Kit isoform (KitA+) containing an in-frame insertion, Gly-Asn-Asn-Lys, within the extracellular domain, was detected in murine mast cell cultures and mid-gestation placenta.	Lysine	150-153	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	84-87
29142126-0	2018	Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein.	Lysine	74-80	ubiquitin conjugating enzyme E2 B	Homo sapiens	88-98
25152236-4	2014	SIRT3 deacetylates PDHA1 lysine 321 (K321), and a PDHA1 mutant mimicking a deacetylated lysine (PDHA1(K321R)) increases PDH activity, compared to the K321 acetylation mimic (PDHA1(K321Q)) or wild-type PDHA1.	Lysine	25-31	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	19-24
25142606-0	2014	Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.	Lysine	0-6	TANK binding kinase 1	Homo sapiens	17-38
29174981-7	2018	Excitingly, Lys-104 (K104), a previously identified lysine acetylation site of TIP60 with unknown function, was observed to be indispensable for inducing p53-mediated apoptosis under low glucose condition.	Lysine	12-15	lysine acetyltransferase 5	Homo sapiens	79-84
29174981-7	2018	Excitingly, Lys-104 (K104), a previously identified lysine acetylation site of TIP60 with unknown function, was observed to be indispensable for inducing p53-mediated apoptosis under low glucose condition.	Lysine	52-58	lysine acetyltransferase 5	Homo sapiens	79-84
1686347-5	1991	However, there are five glutamic acid residues potentially modified to gamma-carboxyglutamic acid (gla) in those species; in murine MGP, lysine replaced glutamic acid 37.	Lysine	137-143	matrix Gla protein	Mus musculus	132-135
1714590-3	1991	A triple mutant, RK3, possessing three Arg----Lys substitutions was constructed that increased the number of lysines per PNP subunit from 14 to 17, providing an additional 18 potential PEG attachment sites per hexameric enzyme molecule.	Lysine	109-116	purine-nucleoside phosphorylase	Mus musculus	121-124
25142606-0	2014	Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.	Lysine	0-6	mitochondrial antiviral signaling protein	Homo sapiens	115-156
25226840-9	2014	In addition, the presence of L-Lys (10 microM) significantly blocked the L-Arg (1,000 microM)-induced reduction in soluble ECE-1 levels (122.38 +- 13.16).	Lysine	29-34	endothelin converting enzyme 1	Homo sapiens	123-128
1676903-4	1991	However, the sequence analysis of ER in the Leydig cell line (B-1 F) revealed a single base change at acidic Glu-279 (GAA) to basic Lys-279 (AAA) compared with murine uterus ER cDNA.	Lysine	132-135	estrogen receptor 1 (alpha)	Mus musculus	34-36
29301528-3	2018	Arginine:glycine amidinotransferase (AGAT) catalyzes the synthesis of L-homoarginine (hArg) from free Arg and L-lysine.	Lysine	110-118	glycine amidinotransferase	Homo sapiens	0-35
29183727-6	2018	In addition, ChIP assay suggested that resveratrol participates in enhancing the gene expression of gp91-phox via promoting acetylation of Lys-9 residues and Lys-14 residues of histone H3 within chromatin around the promoter regions of the gene.	Lysine	139-142	cytochrome b-245 beta chain	Homo sapiens	100-109
29183727-6	2018	In addition, ChIP assay suggested that resveratrol participates in enhancing the gene expression of gp91-phox via promoting acetylation of Lys-9 residues and Lys-14 residues of histone H3 within chromatin around the promoter regions of the gene.	Lysine	158-161	cytochrome b-245 beta chain	Homo sapiens	100-109
29863080-5	2018	However, the lysine residues of Herp, which are ubiquitinated by E3 ubiquitin ligase, were not sufficient for regulation of Herp degradation.	Lysine	13-19	Cbl proto-oncogene like 2	Homo sapiens	65-84
25231979-4	2014	The human FAM86A (family with sequence similarity 86) protein belongs to a recently identified family of protein MTases, and we here show that FAM86A catalyzes the trimethylation of eukaryotic elongation factor 2 (eEF2) on Lys-525.	Lysine	223-226	eukaryotic translation elongation factor 2	Homo sapiens	182-212
25231979-4	2014	The human FAM86A (family with sequence similarity 86) protein belongs to a recently identified family of protein MTases, and we here show that FAM86A catalyzes the trimethylation of eukaryotic elongation factor 2 (eEF2) on Lys-525.	Lysine	223-226	eukaryotic translation elongation factor 2	Homo sapiens	214-218
25231979-5	2014	Moreover, we demonstrate that the Saccharomyces cerevisiae MTase Yjr129c, which displays sequence homology to FAM86A, is a functional FAM86A orthologue, modifying the corresponding residue (Lys-509) in yeast eEF2, both in vitro and in vivo.	Lysine	190-193	eukaryotic translation elongation factor 2	Homo sapiens	208-212
29421780-8	2018	We also demonstrated that SUMO acceptor sites in mouse SERCA2a involving lysine 585, 480 and 571.	Lysine	73-79	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	55-62
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Lysine	320-323	H3 histone pseudogene 16	Homo sapiens	270-273
29421780-9	2018	Among the three acceptor sites, Lut enhanced SERCA2a stability via lysine 585.	Lysine	67-73	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	45-52
25231979-7	2014	In summary, the present study establishes the function of the previously uncharacterized MTases FAM86A and Yjr129c, demonstrating that these enzymes introduce a functionally important lysine methylation in eEF2.	Lysine	184-190	eukaryotic translation elongation factor 2	Homo sapiens	206-210
29421780-10	2018	CONCLUSIONS: Our results suggest that Lut regulates SERCA2a through SUMOylation at lysine 585 to attenuate myocardial I/R injury.	Lysine	83-89	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	52-59
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Lysine	320-323	H3 histone pseudogene 16	Homo sapiens	307-310
25231983-0	2014	Translational roles of elongation factor 2 protein lysine methylation.	Lysine	51-57	elongation factor 2	Saccharomyces cerevisiae S288C	23-42
25231983-3	2014	Here we show that in Saccharomyces cerevisiae, the product of the EFM3/YJR129C gene is responsible for the trimethylation of lysine 509 on elongation factor 2.	Lysine	125-131	elongation factor 2	Saccharomyces cerevisiae S288C	139-158
1368705-3	1991	ORF2 coded for the lysA gene based on the complementation of a B. subtilis lys auxotroph and on the fact that the predicted amino acid sequence (440 amino acids with a molecular weight of 48,876) of ORF2 shared a 29.7%, 38.3%, and 32.9% identity with the sequences of Escherichia coli, Corynebacterium glutamicum and Pseudomonas aeruginosa lysA genes, respectively.	Lysine	19-22	hypothetical protein	Bacillus subtilis	0-4
25340740-4	2014	Tax was found to promote the nondegradative lysine 63 (K63)-linked polyubiquitination of MCL-1 that was dependent on the E3 ubiquitin ligase TRAF6 and the IKK complex.	Lysine	44-50	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-94
1368705-3	1991	ORF2 coded for the lysA gene based on the complementation of a B. subtilis lys auxotroph and on the fact that the predicted amino acid sequence (440 amino acids with a molecular weight of 48,876) of ORF2 shared a 29.7%, 38.3%, and 32.9% identity with the sequences of Escherichia coli, Corynebacterium glutamicum and Pseudomonas aeruginosa lysA genes, respectively.	Lysine	19-22	hypothetical protein	Bacillus subtilis	199-203
29310773-5	2018	Elastin, another class of extracellular matrix protein, is also stabilized by the lysyl oxidase-mediated mechanism but involving only lysine residues leading to the formation of unique tetravalent cross-links.	Lysine	134-140	elastin	Homo sapiens	0-7
25340740-4	2014	Tax was found to promote the nondegradative lysine 63 (K63)-linked polyubiquitination of MCL-1 that was dependent on the E3 ubiquitin ligase TRAF6 and the IKK complex.	Lysine	44-50	TNF receptor associated factor 6	Homo sapiens	141-146
28557341-3	2018	An arginine to lysine mutant at amino acid site 358 could lead to the da1-1 phenotype, which results in an increased organ size and larger seeds.	Lysine	15-21	DA1	Arabidopsis thaliana	70-73
1924492-3	1991	D-2 agonists protected mice against pilocarpine-induced seizures in the rank order of potency PHNO greater than pergolide greater than greater than lisuride = LY 171555 much greater than RU 24213, with ED50 values ranging from 0.17 mg/kg for PHNO to greater than 4.5 mg/kg for RU 24213.	Lysine	159-161	solute carrier family 3 member 1	Rattus norvegicus	0-3
25340740-5	2014	Tax interacted with and activated TRAF6, and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with K63-linked polyubiquitin chains, which stabilized and protected MCL-1 from genotoxic stress-induced degradation.	Lysine	130-136	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	149-154
29302632-1	2017	The recombinant HbI was fused with a poly-Lys tag ((Lys)6-tagged rHbI) for specific-site covalent immobilization on two carbon nanotube transducer surfaces, i.e., powder and vertically aligned carbon nanotubes.	Lysine	42-45	FKBP prolyl isomerase 4	Rattus norvegicus	65-69
29302632-8	2017	More importantly, the electrochemical studies allowed determination of a redox potential for the new (Lys)6-tagged rHbI.	Lysine	102-105	FKBP prolyl isomerase 4	Rattus norvegicus	115-119
25341044-3	2014	Arrest defective 1 (ARD1) is an enzyme that catalyzes not only N-terminal acetylation as a cotranslational modification but also lysine acetylation as a posttranslational modification.	Lysine	129-135	N(alpha)-acetyltransferase 10, NatA catalytic subunit	Mus musculus	0-18
1825118-1	1991	The lysine-rich sequence (-KKGGKKK-) located at the 50,000/20,000 Mr junction of myosin subfragment-1 (S-1) was cleaved by endoprotease Arg-C or by trypsin in the presence of ATP and an equimolar amount of actin.	Lysine	4-10	myosin heavy chain 14	Homo sapiens	81-87
25341044-3	2014	Arrest defective 1 (ARD1) is an enzyme that catalyzes not only N-terminal acetylation as a cotranslational modification but also lysine acetylation as a posttranslational modification.	Lysine	129-135	N(alpha)-acetyltransferase 10, NatA catalytic subunit	Mus musculus	20-24
25100072-6	2014	We identified l-tryptophan, l-arginine, l-cysteine, and l-lysine as the most potent modulators with effective strength comparable to a supraphysiological dose of amylin.	Lysine	56-64	islet amyloid polypeptide	Rattus norvegicus	162-168
1789248-0	1991	Structural analysis of the rat uricase gene and evidence that lysine 164 is involved in the substrate-binding site of the enzyme.	Lysine	62-68	urate oxidase	Rattus norvegicus	31-38
1901809-8	1991	However, deletion of tryptophan or lysine from the culture medium led to 63 and 76% declines in IGF-I release, respectively (both P less than 0.001 vs. complete medium), although omission of cysteine or cysteine plus cystine produced no significant change.	Lysine	35-41	insulin-like growth factor 1	Rattus norvegicus	96-101
29311809-3	2017	Our previous work has shown that transcriptional activation of c-Fos and Egr-1 in the hippocampus requires formation of a dual histone mark within their promoter regions, the phosphorylation of serine 10 and acetylation of lysine 9/14 of histone H3.	Lysine	223-229	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
28888576-8	2017	The Glu/Glu at codon 416 (rs7041) (p&lt;0.05) and Lys/Lys at codon 420 (rs4588) (p&lt;0.01) variants of vitamin D binding protein gene was significantly higher in type 2 diabetic subjects than controls.	Lysine	50-53	GC vitamin D binding protein	Homo sapiens	104-129
28888576-8	2017	The Glu/Glu at codon 416 (rs7041) (p&lt;0.05) and Lys/Lys at codon 420 (rs4588) (p&lt;0.01) variants of vitamin D binding protein gene was significantly higher in type 2 diabetic subjects than controls.	Lysine	54-57	GC vitamin D binding protein	Homo sapiens	104-129
25512736-4	2014	RESULTS: Sequencing analysis identified a nonsense mutation in exon 1 of ARHGAP29 that caused substitution of lysine to stop codon at codon position 32 in a subject with nonsyndromic cleft lip with cleft palate.	Lysine	110-116	Rho GTPase activating protein 29	Homo sapiens	73-81
29036334-8	2017	For HIF-1alpha, however, Tet1 has no effect on HIF-1alpha hydroxylation, but rather it appears to stabilize the C-terminus of HIF-1alpha by affecting lysine site modification.	Lysine	150-156	tet methylcytosine dioxygenase 1	Mus musculus	25-29
29239724-0	2017	SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.	Lysine	10-16	KRAS proto-oncogene, GTPase	Homo sapiens	71-78
29239724-3	2017	Here we report that one of the K-Ras splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied protein post-translational modification.	Lysine	77-83	KRAS proto-oncogene, GTPase	Homo sapiens	31-36
29239724-3	2017	Here we report that one of the K-Ras splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied protein post-translational modification.	Lysine	77-83	KRAS proto-oncogene, GTPase	Homo sapiens	54-61
29239724-5	2017	We further demonstrate that SIRT2-mediated lysine defatty-acylation promotes endomembrane localization of K-Ras4a, enhances its interaction with A-Raf, and thus promotes cellular transformation.	Lysine	43-49	KRAS proto-oncogene, GTPase	Homo sapiens	106-113
2053135-1	1991	Human tissue factor (TF), the membrane-bound glycoprotein receptor for the blood-clotting factor VII/VIIa, contains in its extracellular domain three repeats of the rare motif, tryptophan-lysine-serine (WKS).	Lysine	188-194	coagulation factor III, tissue factor	Homo sapiens	6-19
2053135-1	1991	Human tissue factor (TF), the membrane-bound glycoprotein receptor for the blood-clotting factor VII/VIIa, contains in its extracellular domain three repeats of the rare motif, tryptophan-lysine-serine (WKS).	Lysine	188-194	coagulation factor III, tissue factor	Homo sapiens	21-23
25172487-4	2014	In this study, we report that TRIM33, a member of the tripartite motif (TRIM) family, can bind DHX33 directly and induce DHX33 ubiquitination via the lysine 218 upon dsRNA stimulation.	Lysine	150-156	DEAH-box helicase 33	Homo sapiens	95-100
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	24-30	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	127-133
29235476-6	2017	Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TbetaRI turnover at the cell surface.	Lysine	72-78	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	127-133
25172487-4	2014	In this study, we report that TRIM33, a member of the tripartite motif (TRIM) family, can bind DHX33 directly and induce DHX33 ubiquitination via the lysine 218 upon dsRNA stimulation.	Lysine	150-156	DEAH-box helicase 33	Homo sapiens	121-126
2174887-10	1990	Tryptic digestion of higher order Ubn adducts (n greater than or equal to 4) yielded fragments identical to those of Ub2, indicating that E2(25)K ligates successive Ub molecules primarily or exclusively via Lys-48.	Lysine	207-210	ubiquitin conjugating enzyme E2 K	Homo sapiens	138-145
25172487-6	2014	The ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex.	Lysine	41-47	DEAH-box helicase 33	Homo sapiens	22-27
25172487-6	2014	The ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex.	Lysine	41-47	DEAH-box helicase 33	Homo sapiens	101-106
29255423-6	2017	The CaSR is preferentially activated by aromatic amino acids and responses to L-Leucine and L-Lysine were significantly lower than those to L-Phenylalanine applied to the same site.	Lysine	92-100	LOW QUALITY PROTEIN: extracellular calcium-sensing receptor	Cavia porcellus	4-8
25074266-8	2014	In conclusion, insertion of the instability loop and ubiquitin carrier lysines in combination with direction to the ER are sufficient and required to govern WSB1-mediated ubiquitination of an activating deiodinase enzyme.	Lysine	71-78	WD repeat and SOCS box containing 1	Homo sapiens	157-161
2176869-7	1990	The results indicate the presence of catalytically essential tyrosine and lysine residues at the active site of ACE.	Lysine	74-80	angiotensin-converting enzyme	Oryctolagus cuniculus	112-115
2176870-0	1990	Identification of essential tyrosine and lysine residues in angiotensin converting enzyme: evidence for a single active site.	Lysine	41-47	angiotensin-converting enzyme	Oryctolagus cuniculus	60-89
28905188-1	2017	Lysine (K)-specific demethylase 4A (KDM4A) is a histone demethylase that removes methyl residues from trimethylated or dimethylated histone 3 at lysines 9 and 36.	Lysine	145-152	lysine demethylase 4A	Homo sapiens	0-34
25281686-6	2014	SHL and EBS recognize di- and trimethylated histone H3 at lysine 4 and bind regulatory regions of SOC1 and FT, respectively.	Lysine	58-64	PHD finger family protein / bromo-adjacent homology (BAH) domain-containing protein	Arabidopsis thaliana	0-3
28905188-1	2017	Lysine (K)-specific demethylase 4A (KDM4A) is a histone demethylase that removes methyl residues from trimethylated or dimethylated histone 3 at lysines 9 and 36.	Lysine	145-152	lysine demethylase 4A	Homo sapiens	36-41
28732179-6	2017	However, HYD-1 (Lys-Ile-Lys-Met-Val-Ile-Ser-Trp-Lys-Gly), an integrin antagonist, inhibited the KGF-enhanced epithelial adhesion and rete peg elongation.	Lysine	16-19	msh homeobox 1	Homo sapiens	9-14
2121277-1	1990	Deoxyhypusine formation on the 18 kDa eIF-4D precursor is due to a covalent linkage between a lysine residue of the protein and the aminobutyl moiety derived from spermidine.	Lysine	94-100	eukaryotic translation initiation factor 5A	Homo sapiens	38-44
1698779-8	1990	In each of the proteinases, several of the strongly reacting Lys residues are located relatively close to each other, presumably reflecting steric constraints within the alpha 2M-proteinase complexes as they form.	Lysine	61-64	alpha-2-macroglobulin	Homo sapiens	170-178
28732179-6	2017	However, HYD-1 (Lys-Ile-Lys-Met-Val-Ile-Ser-Trp-Lys-Gly), an integrin antagonist, inhibited the KGF-enhanced epithelial adhesion and rete peg elongation.	Lysine	24-27	msh homeobox 1	Homo sapiens	9-14
25135975-1	2014	The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wide scale is broadly associated with active gene expression, with its mono-, di- and trimethylated forms differentially enriched at promoter and enhancer and other regulatory sequences.	Lysine	240-246	lysine methyltransferase 2D	Homo sapiens	159-164
29225432-10	2017	The active site amino acids such as TYR-21, ASN-34, VAL-35, MET-18, LYS-17, SER-36, ARG- 46 and ARG-14 are key role in the inhibitors activity.	Lysine	68-71	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	60-66
25086053-7	2014	14-3-3gamma Ser(58) phosphorylation and 14-3-3gamma Lys(49) acetylation were blocked using trans-activator of HIV transcription factor 1 peptides coupled to 14-3-3gamma sequences containing Ser(58) or Lys(49).	Lysine	52-55	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	40-51
29190800-2	2017	Recent work has shown that the Estrogen-Related Receptor alpha (ERRalpha) induces LSD1 to demethylate the Lys 9 of histone H3.	Lysine	106-109	lysine demethylase 1A	Homo sapiens	82-86
2167456-9	1990	They are bis-histidine, as in mammalian cytochrome b5, methionine-histidine, typified by cytochrome c and lysine-histidine, recently recognized by spectroscopic methods in cytochrome f. Here we report the electron paramagnetic resonance and near infrared magnetic circular dichroism spectra of the oxidized state of Ps.	Lysine	106-112	cytochrome b5 type A	Homo sapiens	40-53
25086053-7	2014	14-3-3gamma Ser(58) phosphorylation and 14-3-3gamma Lys(49) acetylation were blocked using trans-activator of HIV transcription factor 1 peptides coupled to 14-3-3gamma sequences containing Ser(58) or Lys(49).	Lysine	52-55	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	40-51
25086053-7	2014	14-3-3gamma Ser(58) phosphorylation and 14-3-3gamma Lys(49) acetylation were blocked using trans-activator of HIV transcription factor 1 peptides coupled to 14-3-3gamma sequences containing Ser(58) or Lys(49).	Lysine	201-204	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	0-11
2351680-11	1990	A 13-residue structure with the consensus sequence GSQLKSFGQVKSS is repeated 13 times within the SVS II protein and appears to be involved in the formation of the rat copulatory plug via a transglutaminase reaction cross-linking glutamine and lysine residues.	Lysine	243-249	semenogelin 1	Rattus norvegicus	97-103
29091393-5	2017	FSAP was found to be exclusively activated by the positively charged surfaces polyethylenimine (PEI) and poly-l-lysine (PLL), not by the negatively charged glass or self-assembled monolayer with carboxyl group termination (SAM-COOH), as well as uncharged (Teflon AF) surfaces.	Lysine	105-118	hyaluronan binding protein 2	Homo sapiens	0-4
25086053-7	2014	14-3-3gamma Ser(58) phosphorylation and 14-3-3gamma Lys(49) acetylation were blocked using trans-activator of HIV transcription factor 1 peptides coupled to 14-3-3gamma sequences containing Ser(58) or Lys(49).	Lysine	201-204	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	40-51
2351680-11	1990	A 13-residue structure with the consensus sequence GSQLKSFGQVKSS is repeated 13 times within the SVS II protein and appears to be involved in the formation of the rat copulatory plug via a transglutaminase reaction cross-linking glutamine and lysine residues.	Lysine	243-249	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	189-205
25086053-7	2014	14-3-3gamma Ser(58) phosphorylation and 14-3-3gamma Lys(49) acetylation were blocked using trans-activator of HIV transcription factor 1 peptides coupled to 14-3-3gamma sequences containing Ser(58) or Lys(49).	Lysine	201-204	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	40-51
25086053-9	2014	Taken together, these results indicate that Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamma occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization.	Lysine	72-75	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	95-106
28782640-0	2017	Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14.	Lysine	101-107	CREB binding protein	Mus musculus	57-60
25086053-9	2014	Taken together, these results indicate that Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamma occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization.	Lysine	72-75	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	164-175
28782640-0	2017	Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14.	Lysine	101-107	E1A binding protein p300	Mus musculus	61-65
2119043-4	1990	Administration of OKY-046, ONO-3708, AA-861 and LY-171883 for 12 weeks suppressed the elevation of serum GOT and GPT levels and histopathological changes in CCl4-induced chronic liver injury.	Lysine	48-50	glutamic pyruvic transaminase, soluble	Mus musculus	113-116
24996493-6	2014	Lys administration also induced a decrease of all antioxidant enzyme activities in the brain, as well as an increase of the activities of SOD and CAT in the liver of Gcdh(-/-) mice.	Lysine	0-3	glutaryl-Coenzyme A dehydrogenase	Mus musculus	166-170
2110898-0	1990	Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s.	Lysine	47-50	beta-2-microglobulin	Homo sapiens	23-43
2110898-2	1990	The main cleavage is in the disulphide loop C-terminal to Lys-58, generating a modified form of beta 2-microglobulin with a two-chain structure.	Lysine	58-61	beta-2-microglobulin	Homo sapiens	96-116
2110898-3	1990	The C-terminal Lys-58 in the A chain is highly susceptible to removal by a carboxypeptidase-B-like activity causing the formation of des-Lys58-beta 2-microglobulin.	Lysine	15-18	beta-2-microglobulin	Homo sapiens	143-163
28977641-7	2017	When PP32 and SET/TAF-Ibeta protein levels are down-regulated in vivo, we detect hyperacetylation on lysines 5 and 12 and other H4 lysine residues.	Lysine	101-108	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	5-9
28977641-7	2017	When PP32 and SET/TAF-Ibeta protein levels are down-regulated in vivo, we detect hyperacetylation on lysines 5 and 12 and other H4 lysine residues.	Lysine	101-108	SET nuclear proto-oncogene	Homo sapiens	18-27
28977641-7	2017	When PP32 and SET/TAF-Ibeta protein levels are down-regulated in vivo, we detect hyperacetylation on lysines 5 and 12 and other H4 lysine residues.	Lysine	101-107	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	5-9
25070893-3	2014	We establish that USP17 stabilizes RORgammat protein expression by reducing RORgammat polyubiquitination at its Lys-360 residue.	Lysine	112-115	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	18-23
29101351-4	2017	MSPC senescence is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste homolog 2 (Ezh2) and its trimethylation of histone H3 on Lysine 27 (H3K27me3) mark.	Lysine	162-168	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	116-120
1971226-3	1990	The incorporation of serine protease inhibitors within the experimental procedures suggested that Thy-1 bound to the lysine-containing, protein-binding domain of t-PA thus leaving the active site available to interact with other proteins.	Lysine	117-123	plasminogen activator, tissue type	Rattus norvegicus	162-166
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	sirtuin 2	Homo sapiens	0-5
28597915-3	2017	The lysine specific demethylase 1 (LSD1) demethylates at both of these lysine residues and has been shown to disrupt neuronal maturation and OR expression in the developing embryonic OE.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	35-39
24821015-6	2014	Mutational analysis of the lysine residues in the Hxt1 N-terminal domain demonstrates that the two lysine residues, K12 and K39, serve as the putative ubiquitin-acceptor sites by the Rsp5 ubiquitin ligase.	Lysine	27-33	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	183-187
28965816-5	2017	Moreover, Tetherin recruits E3 ubiquitin ligase MARCH8 to catalyze K27-linked ubiquitin chains on MAVS at lysine 7, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	106-112	bone marrow stromal cell antigen 2	Homo sapiens	10-18
28965816-5	2017	Moreover, Tetherin recruits E3 ubiquitin ligase MARCH8 to catalyze K27-linked ubiquitin chains on MAVS at lysine 7, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Lysine	106-112	membrane associated ring-CH-type finger 8	Homo sapiens	48-54
24821015-6	2014	Mutational analysis of the lysine residues in the Hxt1 N-terminal domain demonstrates that the two lysine residues, K12 and K39, serve as the putative ubiquitin-acceptor sites by the Rsp5 ubiquitin ligase.	Lysine	99-105	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	183-187
28973940-7	2017	Furthermore, MED25 physically and functionally interacts with HISTONE ACETYLTRANSFERASE1 (HAC1), which plays an important role in JA signaling by selectively regulating histone (H) 3 lysine (K) 9 (H3K9) acetylation of MYC2 target promoters.	Lysine	183-189	mediator complex subunit 25	Homo sapiens	13-18
33237287-1	2020	The heterochromatin protein 1 (HP1) family members are canonical effectors and propagators of gene repression mediated by histone H3 lysine 9 (H3K9) methylation.	Lysine	133-139	chromobox 5	Homo sapiens	4-29
33237287-1	2020	The heterochromatin protein 1 (HP1) family members are canonical effectors and propagators of gene repression mediated by histone H3 lysine 9 (H3K9) methylation.	Lysine	133-139	chromobox 5	Homo sapiens	31-34
24788237-1	2014	Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR), which could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation of multiple downstream genes, is involved in development and progression of esophageal squamous cell carcinoma (ESCC).	Lysine	169-175	HOX transcript antisense RNA	Homo sapiens	58-64
28371863-1	2017	Aims: The E143K (Glu   Lys) mutation in the myosin essential light chain has been associated with restrictive cardiomyopathy (RCM) in humans, but the mechanisms that underlie the development of defective cardiac function are unknown.	Lysine	23-26	myosin heavy chain 14	Homo sapiens	44-50
29228717-5	2017	Restored PRDM2 increased global histone 3 lysine 9 dimethylation and reduced migration, anchorage-independent growth and tumor growth in vivo.	Lysine	42-48	PR/SET domain 2	Homo sapiens	9-14
24966184-8	2014	Cardiac lysine acetylation was increased in SIRT3 KO mice compared with WT mice, including increased acetylation and activity of LCAD and beta-HAD.	Lysine	8-14	sirtuin 3	Mus musculus	44-49
29098080-4	2017	Here we report the first PTM with functional characterization on YY2, namely lysine 247 monomethylation (K247me1), which was found to be dynamically regulated by SET7/9 and LSD1 both in vitro and in cultured cells.	Lysine	77-83	YY2 transcription factor	Homo sapiens	65-68
29098080-4	2017	Here we report the first PTM with functional characterization on YY2, namely lysine 247 monomethylation (K247me1), which was found to be dynamically regulated by SET7/9 and LSD1 both in vitro and in cultured cells.	Lysine	77-83	lysine demethylase 1A	Homo sapiens	173-177
26229056-7	2015	Throughout the genome of differentiating adult myoblasts, the cooperation between Six4 and MyoD is associated with chromatin repressive mark removal by Utx, a demethylase of histone H3 trimethylated at lysine 27.	Lysine	202-208	sine oculis-related homeobox 4	Mus musculus	82-86
26229056-7	2015	Throughout the genome of differentiating adult myoblasts, the cooperation between Six4 and MyoD is associated with chromatin repressive mark removal by Utx, a demethylase of histone H3 trimethylated at lysine 27.	Lysine	202-208	myogenic differentiation 1	Mus musculus	91-95
25105367-4	2014	We sequenced exons and surrounding areas of FcR-encoding genes and found one FCGR2C tag SNP (rs114945036) that associated with VE against HIV-1 subtype CRF01_AE, with lysine at position 169 (169K) in the V2 loop (CRF01_AE 169K).	Lysine	167-173	Fc gamma receptor IIc (gene/pseudogene)	Homo sapiens	77-83
26229056-7	2015	Throughout the genome of differentiating adult myoblasts, the cooperation between Six4 and MyoD is associated with chromatin repressive mark removal by Utx, a demethylase of histone H3 trimethylated at lysine 27.	Lysine	202-208	lysine (K)-specific demethylase 6A	Mus musculus	152-155
34798108-3	2022	Herein, we developed an integrated structural strategy to systematically profile the molecular details of dynamic interactions among PFOA, SA, and beta-cyclodextrin (beta-CD) by combing native mass spectrometry (nMS), lysine reactivity profiling (LRP), and molecular docking (MD) simulation.	Lysine	218-224	ACD shelterin complex subunit and telomerase recruitment factor	Bos taurus	166-173
28481620-8	2017	Using chromatin immunoprecipitation, we observed a reduction of trimethylated histone 3 lysine 9 at the RIG-I promoter.	Lysine	88-94	DExD/H-box helicase 58	Homo sapiens	104-109
28666590-4	2017	For example, TLS is mediated by mono-ubiquitination of PCNA at lysine 164, for which RAD6-RAD18 is the primary E2-E3 complex.	Lysine	63-69	RAD18 E3 ubiquitin protein ligase	Homo sapiens	90-95
25144183-4	2014	By using ProSeAM as a chemical probe for lysine methylation, we identified substrates for two seven-beta-strand KMTs, METTL21A and METTL10, on a proteomic scale in mammalian cells.	Lysine	41-47	methyltransferase 21A, HSPA lysine	Homo sapiens	118-126
28534506-4	2017	LSD1 demethylates HIF1alpha at lysine (K) 391, which protects HIF1alpha against ubiquitin-mediated protein degradation.	Lysine	31-37	lysine demethylase 1A	Homo sapiens	0-4
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Lysine	15-28	dipeptidyl peptidase 4	Homo sapiens	165-187
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Lysine	15-28	dipeptidyl peptidase 4	Homo sapiens	189-193
28948228-3	2017	We identified a stratified model for RIG-I amino-terminal ubiquitination, in which initiation at either Lys164 or Lys172 allows subsequent ubiquitination at other lysines, to trigger and amplify RIG-I activation.	Lysine	163-170	DExD/H-box helicase 58	Homo sapiens	37-42
25092319-4	2014	UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238 in an IR-stimulated manner, which decreases ATMIN interaction with ATM and promotes MRN-mediated signaling.	Lysine	67-73	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	0-4
28779964-4	2017	The conserved SET1/MLL family of histone methyltransferases (HMT) catalyzes methylation of histone H3 on Lysine 4 (H3K4), a histone modification universally associated with actively transcribed genes.	Lysine	105-111	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	14-18
34643933-0	2022	The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2.	Lysine	40-43	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	131-136
34694569-10	2022	ANKRD13A recognizes Lys-63-linked polyubiquitin chain in HLA-I.	Lysine	20-23	ankyrin repeat domain 13A	Homo sapiens	0-8
25092319-4	2014	UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238 in an IR-stimulated manner, which decreases ATMIN interaction with ATM and promotes MRN-mediated signaling.	Lysine	67-73	ATM serine/threonine kinase	Homo sapiens	20-23
28696214-9	2017	Moreover, the AhR-MTA2 interaction is CA-dependent and results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation.	Lysine	185-191	stanniocalcin 2	Homo sapiens	90-94
25092319-5	2014	We show that UBR5 deficiency, or mutation of ATMIN lysine 238, prevents ATMIN dissociation from ATM and inhibits ATM and NBS1 foci formation after IR, thereby impairing checkpoint activation and increasing radiosensitivity.	Lysine	51-57	ATM serine/threonine kinase	Homo sapiens	45-48
25092319-5	2014	We show that UBR5 deficiency, or mutation of ATMIN lysine 238, prevents ATMIN dissociation from ATM and inhibits ATM and NBS1 foci formation after IR, thereby impairing checkpoint activation and increasing radiosensitivity.	Lysine	51-57	ATM serine/threonine kinase	Homo sapiens	72-75
25049398-0	2014	Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.	Lysine	0-6	tumor protein p53 binding protein 1	Homo sapiens	40-45
28884161-1	2017	The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78 catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the proteasomal degradation of misfolded proteins in the endoplasmic reticulum.	Lysine	108-114	ubiquitin conjugating enzyme E2 G2	Homo sapiens	33-39
28884161-1	2017	The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78 catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the proteasomal degradation of misfolded proteins in the endoplasmic reticulum.	Lysine	108-114	autocrine motility factor receptor	Homo sapiens	76-80
28696707-1	2017	Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen.	Lysine	156-162	peptidylprolyl isomerase B	Mus musculus	0-13
28696707-1	2017	Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen.	Lysine	156-162	peptidylprolyl isomerase B	Mus musculus	15-19
34838590-3	2022	Here we characterize the effects of a recently discovered tau PTM, lysine succinylation, on tau-tubulin interactions, and compare these to the effects of two previously reported MBD modifications, lysine acetylation and tyrosine phosphorylation.	Lysine	67-73	microtubule associated protein tau	Homo sapiens	58-61
34838590-3	2022	Here we characterize the effects of a recently discovered tau PTM, lysine succinylation, on tau-tubulin interactions, and compare these to the effects of two previously reported MBD modifications, lysine acetylation and tyrosine phosphorylation.	Lysine	67-73	microtubule associated protein tau	Homo sapiens	92-95
34800882-9	2021	Regarding to the mechanism, we found that Ketamine inhibited the expression of GPX4, an anti-ferroptosis factor, by attenuating KAT5 on the promoter region of GPX4, repressing the enrichment of histone H3 lysine 27 acetylation (H3K27ac) and RNA polymerase II (RNA pol II).	Lysine	205-211	glutathione peroxidase 4	Homo sapiens	79-83
28696707-1	2017	Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen.	Lysine	164-167	peptidylprolyl isomerase B	Mus musculus	0-13
28696707-1	2017	Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen.	Lysine	164-167	peptidylprolyl isomerase B	Mus musculus	15-19
25049398-4	2014	Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the role of the 53BP1 tandem tudor domain in recognition of the methylated lysine and surrounding residues.	Lysine	164-170	tumor protein p53 binding protein 1	Homo sapiens	26-31
34974029-4	2022	We revealed that the activity of the fusion gene chimera EWSR1-FLI1, the genetic driver of Ewing sarcoma, leads to lower expression of the gene SPARC in these tumors, likely due to enriched acetylation marks of the histone H3 lysine 27 at regions including the SPARC promoter and potential enhancers.	Lysine	226-232	secreted protein acidic and cysteine rich	Homo sapiens	144-149
25049398-4	2014	Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the role of the 53BP1 tandem tudor domain in recognition of the methylated lysine and surrounding residues.	Lysine	164-170	tumor protein p53 binding protein 1	Homo sapiens	105-110
24920679-8	2014	In this study, acetylcholine stimulation induced cortactin deacetylation in mouse and human smooth muscle tissues, as evidenced by immunoblot analysis using antibody against acetylated lysine.	Lysine	185-191	cortactin	Mus musculus	49-58
34961760-0	2021	Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2.	Lysine	8-14	sirtuin 2	Homo sapiens	97-102
28898989-2	2017	Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3).	Lysine	200-206	embryonic ectoderm development	Homo sapiens	23-26
28601046-0	2017	LSD1 knockdown reveals novel histone lysine methylation in human breast cancer MCF-7 cells.	Lysine	37-43	lysine demethylase 1A	Homo sapiens	0-4
24252090-4	2014	OSCP was further investigated and lysine 139 is a nutrient-sensitive SIRT3-dependent deacetylation target.	Lysine	34-40	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	Mus musculus	0-4
28601046-6	2017	Our results show that LSD1 knockdown has a broad effect on histone lysine methylation, which indicates that LSD1 regulates histone lysine methylation in collaboration with other KMTs and KDMs.	Lysine	67-73	lysine demethylase 1A	Homo sapiens	22-26
28601046-6	2017	Our results show that LSD1 knockdown has a broad effect on histone lysine methylation, which indicates that LSD1 regulates histone lysine methylation in collaboration with other KMTs and KDMs.	Lysine	67-73	lysine demethylase 1A	Homo sapiens	108-112
28601046-6	2017	Our results show that LSD1 knockdown has a broad effect on histone lysine methylation, which indicates that LSD1 regulates histone lysine methylation in collaboration with other KMTs and KDMs.	Lysine	131-137	lysine demethylase 1A	Homo sapiens	22-26
28601046-6	2017	Our results show that LSD1 knockdown has a broad effect on histone lysine methylation, which indicates that LSD1 regulates histone lysine methylation in collaboration with other KMTs and KDMs.	Lysine	131-137	lysine demethylase 1A	Homo sapiens	108-112
28428079-3	2017	In bone, OPN exists both as a monomer and as a high-molecular-weight polymer - the latter is formed by transglutaminase-mediated crosslinking of glutamine and lysine residues in OPN to create homotypic protein assemblies.	Lysine	159-165	secreted phosphoprotein 1	Bos taurus	9-12
28428079-3	2017	In bone, OPN exists both as a monomer and as a high-molecular-weight polymer - the latter is formed by transglutaminase-mediated crosslinking of glutamine and lysine residues in OPN to create homotypic protein assemblies.	Lysine	159-165	secreted phosphoprotein 1	Bos taurus	178-181
28572241-3	2017	Short-term activation (&lt;30 minutes) of protein kinase C (PKC) promotes the attachment of a lysine 48-linked polyubiquitin chain to hOAT1, a process catalyzed by ubiquitin ligase neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2).	Lysine	94-100	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	181-247
28572241-3	2017	Short-term activation (&lt;30 minutes) of protein kinase C (PKC) promotes the attachment of a lysine 48-linked polyubiquitin chain to hOAT1, a process catalyzed by ubiquitin ligase neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2).	Lysine	94-100	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	249-256
34957905-0	2021	Hb Dahua (beta59(E3)Lys Met; HBB: c.179A>T) a Novel Variant on the beta-Globin Gene.	Lysine	20-23	hemoglobin subunit beta	Homo sapiens	67-78
34957905-6	2021	Direct DNA sequencing of the beta-globin gene revealed heterozygosity for a missense mutation at codon 59 (AAG>ATG), causing a lysine to methionine substitution (beta59(E3)Lys Met; HBB: c.179A>T).	Lysine	127-133	hemoglobin subunit beta	Homo sapiens	29-40
34957905-6	2021	Direct DNA sequencing of the beta-globin gene revealed heterozygosity for a missense mutation at codon 59 (AAG>ATG), causing a lysine to methionine substitution (beta59(E3)Lys Met; HBB: c.179A>T).	Lysine	172-175	hemoglobin subunit beta	Homo sapiens	29-40
34992428-9	2021	Frequencies of XPD Lys751Gln genotypes in cases were 62.7% heterozygous Lys/Gln, 24% homozygous Lys/Lys and 13.3% homozygous Gln/Gln, while in the controls were 74.7%, 20%, and 5.3%, respectively.	Lysine	72-75	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	15-18
28572241-8	2017	These results suggest that PKC-regulated and Nedd4-2-catalyzed attachment of a lysine 48-linked polyubiquitin chain to hOAT1 is important for hOAT1 stability.	Lysine	79-85	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	45-52
24252090-4	2014	OSCP was further investigated and lysine 139 is a nutrient-sensitive SIRT3-dependent deacetylation target.	Lysine	34-40	sirtuin 3	Mus musculus	69-74
24962578-5	2014	In particular, Tyr-381 phosphorylation of PDP1 dissociates deacetylase SIRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylation of PDHA1 and PDP1.	Lysine	156-162	acetyl-CoA acetyltransferase 1	Homo sapiens	108-113
28130418-4	2017	Conformational changes of the TM 5 segment containing Lys-539 by cleavage of the 38-kDa fragment remain unclear.	Lysine	54-57	tropomyosin 3	Homo sapiens	30-34
28130418-10	2017	Taken together, we propose that the conformational changes of the TM 5 segment characterized by the sequestration and restricted motion of Lys-539 are induced by the cleavage of the loop region between the TM 7 and the TM 8.	Lysine	139-142	tropomyosin 3	Homo sapiens	66-70
28130418-10	2017	Taken together, we propose that the conformational changes of the TM 5 segment characterized by the sequestration and restricted motion of Lys-539 are induced by the cleavage of the loop region between the TM 7 and the TM 8.	Lysine	139-142	tetraspanin 16	Homo sapiens	219-223
34942305-10	2022	Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis.	Lysine	261-267	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	68-73
34942305-10	2022	Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis.	Lysine	261-267	sterol regulatory element binding transcription factor 1	Homo sapiens	108-151
34942305-10	2022	Mechanistically, SETD8, which was posttranslationally stabilized by USP17, could transcriptionally modulate sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor in fatty acid biosynthesis and lipogenesis, by monomethylating the 20th lysine of the H4 histone, elevating lipid biosynthesis and accumulation in RCC and further promoting cancer progression and metastasis.	Lysine	261-267	sterol regulatory element binding transcription factor 1	Homo sapiens	153-159
24962578-5	2014	In particular, Tyr-381 phosphorylation of PDP1 dissociates deacetylase SIRT3 and recruits acetyltransferase ACAT1 to PDC, resulting in increased inhibitory lysine acetylation of PDHA1 and PDP1.	Lysine	156-162	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	178-183
34850951-2	2021	We revisited this model, in the context of EGF-inducible gene expression and found that rather than a simple unifying model, there are two broad classes of genes; one in which high lysine acetylation activity is required for efficient gene activation, and a second group where the opposite occurs and high acetylation activity is inhibitory.	Lysine	181-187	epidermal growth factor	Homo sapiens	43-46
24831241-3	2014	We find that accessory (Lys -3, Trp -2, Ser -1 and Leu +2) and canonical (D -4, Leu 0 and Leu +1) residues confer the DKWSLLL signal with the versatility required for the Cu(+)-regulated cycling of ATP7B between the trans-Golgi network (TGN) and the plasma membrane (PM).	Lysine	24-27	deleted in lymphocytic leukemia 1	Homo sapiens	51-57
34850951-3	2021	We examined the latter class in more detail using EGR2 as a model gene and found that lysine acetylation levels are critical for several activation parameters, including the timing of expression onset, and overall amplitudes of the transcriptional response.	Lysine	86-92	early growth response 2	Homo sapiens	50-54
28657737-4	2017	Instead, the high-impact chemosensates polygodial, warburganal, and 1beta-acetoxy-9-deoxy-isomuzigadial showed immediate reactivity with the epsilon-amino group of lysine side chains to give pyrrole-type conjugates, thus showing evidence for TRPA1 activation by covalent lysine modification.	Lysine	164-170	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	242-247
28657737-4	2017	Instead, the high-impact chemosensates polygodial, warburganal, and 1beta-acetoxy-9-deoxy-isomuzigadial showed immediate reactivity with the epsilon-amino group of lysine side chains to give pyrrole-type conjugates, thus showing evidence for TRPA1 activation by covalent lysine modification.	Lysine	271-277	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	242-247
34645607-5	2021	Furthermore, overall increased acetylation of histone H3 lysine 27 was observed in F. nucleatum infected CRC cells and patient tumors, which was responsible for the corresponding transcriptional upregulation of ANGPTL4.	Lysine	57-63	angiopoietin like 4	Homo sapiens	211-218
24831241-3	2014	We find that accessory (Lys -3, Trp -2, Ser -1 and Leu +2) and canonical (D -4, Leu 0 and Leu +1) residues confer the DKWSLLL signal with the versatility required for the Cu(+)-regulated cycling of ATP7B between the trans-Golgi network (TGN) and the plasma membrane (PM).	Lysine	24-27	deleted in lymphocytic leukemia 1	Homo sapiens	90-96
34826680-1	2021	Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the diaminopimelate pathway for lysine biosynthesis, has become an attractive target for the development of new antibacterial and herbicidal agents.	Lysine	114-120	dihydrodipicolinate synthase	Escherichia coli	0-28
28592682-9	2017	Modeling and direct investigation of the N-terminal sequence of betaA4 crystallin, as well as a variety of homologous peptides, showed that the epsilon amino group of Lys can promote DHA production by nucleophilic attack on the alpha proton of cystine.	Lysine	167-170	crystallin beta A4	Homo sapiens	64-81
24907272-8	2014	Taken together, we establish that the ARM is required for RNF4 to efficiently target Ser(P)-824-SUMO-KAP1, conferring ubiquitin Lys-48-mediated proteasomal degradation in the context of double strand breaks.	Lysine	128-131	ring finger protein 4	Homo sapiens	58-62
25001286-1	2014	Although selective binding of 53BP1 to dimethylated histone H4 lysine 20 (H4K20me2) at DNA double-strand breaks (DSBs) is a necessary and pivotal determinant of nonhomologous end joining (NHEJ)-directed repair, the enzymes that generate H4K20me2 at DSBs were unclear.	Lysine	63-69	tumor protein p53 binding protein 1	Homo sapiens	30-35
29207681-3	2017	As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.	Lysine	149-155	lysine demethylase 4C	Homo sapiens	59-65
29207681-3	2017	As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.	Lysine	175-181	lysine demethylase 4C	Homo sapiens	59-65
34826680-1	2021	Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the diaminopimelate pathway for lysine biosynthesis, has become an attractive target for the development of new antibacterial and herbicidal agents.	Lysine	114-120	dihydrodipicolinate synthase	Escherichia coli	30-35
25043185-2	2014	We show here that hypoxia causes decreased histone H3 lysine 4 (H3K4) methylation at the MLH1 promoter via the action of the H3K4 demethylases LSD1 and PLU-1 and promotes durable long-term silencing in a pathway that requires LSD1.	Lysine	54-60	mutL homolog 1	Homo sapiens	89-93
34966788-3	2021	Mounting experiment evidence demonstrated the acetylation of a single-lysine residue K280 in the PHF6* was a critical event for the formation of pathological Tau amyloid deposits.	Lysine	70-76	microtubule associated protein tau	Homo sapiens	158-161
28366637-13	2017	The administration of a lysine analogue significantly decreased both transfusion risk (pooled RR 0.52, 95% CI 0.34-0.80) and blood loss (SMD -1.57, 95% CI -2.21 to -0.92).	Lysine	24-30	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	137-143
25036098-8	2014	We show that a four lysine module located within the B insert of Drp1 interacts preferentially with CL over other anionic lipids.	Lysine	20-26	dynamin 1 like	Homo sapiens	65-69
28461393-7	2017	The acetylation of CREBH at lysine residue 294 controls CREBH-PPARalpha interaction and synergy in regulating hepatic glucose metabolism in mice.	Lysine	28-34	cAMP responsive element binding protein 3-like 3	Mus musculus	19-24
28461393-7	2017	The acetylation of CREBH at lysine residue 294 controls CREBH-PPARalpha interaction and synergy in regulating hepatic glucose metabolism in mice.	Lysine	28-34	cAMP responsive element binding protein 3-like 3	Mus musculus	56-61
34418551-3	2021	Here we show that Arabidopsis UBC13A and UBC13B, the major drivers of lysine 63 (K63)-linked polyubiquitination, directly interact with PARPs/PARGs.	Lysine	70-76	ubiquitin-conjugating enzyme 35	Arabidopsis thaliana	30-36
25032863-3	2014	Here we demonstrate that acetylation of lysine 487 (K487) and SUMO1 conjugation of K490 at PML protein are mutually exclusive.	Lysine	40-46	PML nuclear body scaffold	Homo sapiens	91-94
34871326-3	2021	We demonstrate that RSK1 undergoes robust SUMOylation during KSHV lytic replication at lysine residues K110, K335, and K421.	Lysine	87-93	ribosomal protein S6 kinase A1	Homo sapiens	20-24
34817054-7	2021	We further examined relationship between the MCM hexamer states and the methylation levels at lysine 20 of histone H4 (H4K20) and found that the double MCM hexamer state was correlated with di/trimethyl-H4K20 (H4K20me2/3).	Lysine	94-100	H4 clustered histone 6	Homo sapiens	107-117
28479296-6	2017	While ACSF3 was required for the metabolism and therefore detoxification of malonate, ACSF3-derived malonyl-CoA was specifically required for lysine malonylation of mitochondrial proteins.	Lysine	142-148	acyl-CoA synthetase family member 3	Homo sapiens	86-91
24846647-2	2014	One such modification, the acetylation of lysine 40 of alpha-tubulin, located in the lumen of microtubules, is associated with stable, long-living microtubule structures.	Lysine	42-48	tubulin alpha 1b	Homo sapiens	55-68
28460359-1	2017	G9a (also known as KMT1C or EHMT2) is initially identified as a H3K9 methyltransferase that specifically mono- and dimethylates "Lys-9" of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.	Lysine	129-132	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
28460359-1	2017	G9a (also known as KMT1C or EHMT2) is initially identified as a H3K9 methyltransferase that specifically mono- and dimethylates "Lys-9" of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.	Lysine	129-132	euchromatic histone lysine methyltransferase 2	Homo sapiens	19-24
28460359-1	2017	G9a (also known as KMT1C or EHMT2) is initially identified as a H3K9 methyltransferase that specifically mono- and dimethylates "Lys-9" of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.	Lysine	129-132	euchromatic histone lysine methyltransferase 2	Homo sapiens	28-33
34601098-4	2021	The lysine 312 residue (K312) was selected as the target site in ANXA1 because it is associated with SIRT2, and its mimic (K312Q) and silent (K312R) mutants were then established through site mutagenesis.	Lysine	4-10	sirtuin 2	Homo sapiens	101-106
25083348-9	2014	Ion-lock SP-C molecules were prepared by incorporating single or double Glu(-)-Lys(+) into the parent SP-C"s.	Lysine	79-82	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	9-13
34647359-1	2021	OBJECTIVES: RNF20 is recognized as a main E3 ligase for monoubiquitination of histone H2B at lysine 120 (H2Bub).	Lysine	93-99	ring finger protein 20	Sus scrofa	12-17
34396798-0	2021	Lysine-specific demethylase 1 induced epithelial-mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway.	Lysine	0-6	notch receptor 1	Rattus norvegicus	117-122
28561045-3	2017	Here we demonstrate that DNA nanostructures coated by oligolysines to 0.5:1 N:P (ratio of nitrogen in lysine to phosphorus in DNA), are stable in low salt and up to tenfold more resistant to DNase I digestion than when uncoated.	Lysine	59-65	deoxyribonuclease I	Mus musculus	191-198
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Lysine	159-162	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	66-71
34768127-9	2021	The acetylation level of lysine 142 in HSP90B1 was found to be obvious in the UC colon, and point mutation of HSP90B1-K142ac would result in the decreasing secretion of TNF-alpha and IL-2 in LPS-stimulated cultured cells.	Lysine	25-31	interleukin 2	Mus musculus	183-187
25083348-16	2014	Although standard (12)C-FTIR study showed that the alpha-helicity of these SP-C sequences in lipids was uniformly increased with Glu(-)-Lys(+) insertions, elevated surfactant activity was only selectively observed.	Lysine	136-139	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	75-79
28279929-2	2017	When located on the plasma membrane, full-length 135kDa CDCP1 can undergo proteolysis mediated by serine proteases that cleave after two adjacent amino acids (arginine 368 and lysine 369).	Lysine	176-182	CUB domain containing protein 1	Homo sapiens	56-61
25083348-18	2014	SP-Css ion-lock 1, an SP-Css with a salt-bridge for a Glu(-)-Lys(+) ion-pair predicted from MPEx hydropathy calculations, demonstrated enhanced surfactant activity and a transmembrane helix simulating those of native SP-C.	Lysine	61-64	pulmonary surfactant-associated protein C	Oryctolagus cuniculus	0-4
24910440-5	2014	We mapped SUMOylation sites within Psmd1 and found that SUMOylation of a critical lysine immediately adjacent to the Adrm1-binding domain regulates the association of Adrm1 with Psmd1.	Lysine	82-88	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	117-122
28955761-4	2017	We identified several lysine modifications in H3 variants, including testis-specific histone H3 (H3t), through their successful separation with MS-based strategy, based on differences in masses, retention times, and presence of immonium ions.	Lysine	22-28	histocompatibility 3	Mus musculus	46-48
34258881-5	2021	The topoisomerase-1 inhibitor irinotecan induces acetylation of several lysine residues within p53.	Lysine	72-78	transformation related protein 53, pseudogene	Mus musculus	95-98
24910440-5	2014	We mapped SUMOylation sites within Psmd1 and found that SUMOylation of a critical lysine immediately adjacent to the Adrm1-binding domain regulates the association of Adrm1 with Psmd1.	Lysine	82-88	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	167-172
34724040-1	2021	KMT2D, as one of the key histone methyltransferases responsible for histone 3 lysine 4 methylation (H3K4me), has been proved to be the main pathogenic gene of Kabuki syndrome disease.	Lysine	78-84	lysine methyltransferase 2D	Homo sapiens	0-5
28414905-6	2017	Upon coexpressing ORF26 with a metabolic pathway that produced 5-aminovaleric acid from lysine, we were able to demonstrate production of delta-valerolactam from lysine.	Lysine	88-94	hypothetical protein	Escherichia coli	18-23
24949976-3	2014	We report the structure of a trapped RING E3-E2~UBL-target intermediate representing RBX1-UBC12~NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.	Lysine	197-203	ubiquitin conjugating enzyme E2 M	Homo sapiens	90-95
28414905-6	2017	Upon coexpressing ORF26 with a metabolic pathway that produced 5-aminovaleric acid from lysine, we were able to demonstrate production of delta-valerolactam from lysine.	Lysine	162-168	hypothetical protein	Escherichia coli	18-23
34758305-4	2021	We demonstrate that the lysine acetyltransferase p300 targets MCL1 at K40 for acetylation, which is counteracted by the deacetylase sirtuin 3 (SIRT3).	Lysine	24-30	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	62-66
24816145-4	2014	Because USP2cc cleaves the isopeptidyl bond between the ubiquitin C-terminus and the epsilon-amino group of the ubiquitinated lysine, this enzyme reintroduces primary epsilon-amino groups in proteins.	Lysine	126-132	ubiquitin specific peptidase 2	Homo sapiens	8-12
34696588-4	2021	In case of the transimination reaction involving SHMT, the PLP molecule bound to the active site lysine residue of SHMT (internal aldimine) gets detached from the enzyme by a serine substrate to produce an external aldimine complex, where the PLP is now bound to the serine substrate.	Lysine	97-103	serine hydroxymethyltransferase 1	Homo sapiens	49-53
34696588-4	2021	In case of the transimination reaction involving SHMT, the PLP molecule bound to the active site lysine residue of SHMT (internal aldimine) gets detached from the enzyme by a serine substrate to produce an external aldimine complex, where the PLP is now bound to the serine substrate.	Lysine	97-103	serine hydroxymethyltransferase 1	Homo sapiens	115-119
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Lysine	377-383	serine hydroxymethyltransferase 1	Homo sapiens	98-102
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Lysine	497-503	serine hydroxymethyltransferase 1	Homo sapiens	98-102
28424240-6	2017	Interestingly, instead of directly acetylating NFAT, Gcn5 catalyzes histone H3 lysine H9 acetylation to promote IL-2 production.	Lysine	79-85	lysine acetyltransferase 2A	Homo sapiens	53-57
28415650-5	2017	It is well-established that the activity/expression of Zap70 is regulated by post-translational modifications of crucial amino acids including the phosphorylation of tyrosines and the ubiquitination of lysines.	Lysine	202-209	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	55-60
27765079-7	2017	In conclusion, results indicate that broilers fed diets with higher levels of digestible lysine have increased messenger RNA expression of some genes coded in the mitochondrial electron transport chain (ND1, CYTB, COX I, COX II and COX III).	Lysine	89-95	LOC100797098	Glycine max	208-212
27765079-7	2017	In conclusion, results indicate that broilers fed diets with higher levels of digestible lysine have increased messenger RNA expression of some genes coded in the mitochondrial electron transport chain (ND1, CYTB, COX I, COX II and COX III).	Lysine	89-95	cytochrome c oxidase subunit 2, mitochondrial	Glycine max	221-227
34803610-2	2021	SETD1A is a chromatin remodeler that influences gene expression through the modulation of mono- di- and trimethylation marks on Histone-H3-Lysine-4 (H3K4me1/2/3).	Lysine	139-145	SET domain containing 1A	Mus musculus	0-6
24843136-1	2014	Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.	Lysine	73-79	REST corepressor 1	Homo sapiens	136-142
34724565-0	2022	The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.	Lysine	12-18	lysine acetyltransferase 7	Homo sapiens	37-41
34724565-1	2022	The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylation (H3K14Ac) and the expression of embryonic patterning genes.	Lysine	111-117	lysine acetyltransferase 7	Homo sapiens	30-34
34724565-1	2022	The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylation (H3K14Ac) and the expression of embryonic patterning genes.	Lysine	111-117	lysine acetyltransferase 7	Homo sapiens	36-41
28065793-8	2017	However, the distribution of ubiquitinated lysine residues was altered in polyQ expanded ataxin-3, with increased ubiquitination at the new identified ubiquitination site lysine-8.	Lysine	43-49	ataxin 3	Homo sapiens	89-97
28430144-6	2017	Dietary lysine excess may lead to: (1) decreased muscle protein degradation via the down-regulated DNAJA1, HSP90AA1, HSPH1, and UBE2D3 mRNA; and (2) reduced lipid biosynthesis via the down-regulated CFD and ME1 mRNA.	Lysine	8-14	DnaJ heat shock protein family (Hsp40) member A1	Sus scrofa	99-105
24843136-1	2014	Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.	Lysine	73-79	REST corepressor 1	Homo sapiens	143-161
24843136-1	2014	Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.	Lysine	73-79	REST corepressor 1	Homo sapiens	163-168
28348226-1	2017	Lysine Specific Demethylase 1 (LSD1) removes mono- and dimethyl groups from lysine 4 of histone H3 (H3K4) or H3K9, resulting in repressive or activating (respectively) transcriptional histone marks.	Lysine	76-82	lysine demethylase 1A	Homo sapiens	0-29
24879150-6	2014	We report that UCHL1 dysfunction aggravated the hIAPP-induced defect in the autophagy/lysosomal pathway, illustrated by the marked accumulation of autophagosomes and cytoplasmic inclusions positive for SQSTM1/p62 and polyubiquitinated proteins with lysine 63-specific ubiquitin chains.	Lysine	249-255	ubiquitin C-terminal hydrolase L1	Homo sapiens	15-20
28348226-1	2017	Lysine Specific Demethylase 1 (LSD1) removes mono- and dimethyl groups from lysine 4 of histone H3 (H3K4) or H3K9, resulting in repressive or activating (respectively) transcriptional histone marks.	Lysine	76-82	lysine demethylase 1A	Homo sapiens	31-35
28103160-0	2017	Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells.	Lysine	78-84	membrane associated ring-CH-type finger 8	Homo sapiens	147-153
28103160-7	2017	YopJ-mediated Ser- and Lys-acetylation of MARCH8 is further confirmed by Western blotting using the specific antibodies against MARCH8 Sac71 and pan-acetyl lysine.	Lysine	23-26	membrane associated ring-CH-type finger 8	Homo sapiens	42-48
34841684-10	2021	Furthermore, as the lysine-specific demethylase, LSD1 could resist methylation on TRAF2 induced by SMYD2.	Lysine	20-26	TNF receptor-associated factor 2	Mus musculus	82-87
34718606-5	2022	We found that SIRT3ct but not SIRT3mt was promptly degraded by ubiquitin-dependent degradation, in which SIRT3ct degradation was mediated mainly by ubiquitination of NH2-terminal methionine and partly by that of lysine residues of SIRT3ct.	Lysine	212-218	sirtuin 3	Mus musculus	105-110
28103160-8	2017	Functional study demonstrates that YopJ-mediated Ser- and Lys-acetylation affects the auto-ubiquitination of MARCH8.	Lysine	58-61	membrane associated ring-CH-type finger 8	Homo sapiens	109-115
24895758-3	2014	The uptake of lysine (Lys) via the roots was not altered in loss-of-function mutants, in accordance with the minor expression of CAT1 in roots, but plants ectopically overexpressing CAT1 incorporated Lys at higher rates.	Lysine	14-20	catalase 1	Arabidopsis thaliana	182-186
28103160-10	2017	In support, MARCH8 is indeed acetylated at serine and lysine in vitro by purified YopJ but the activity is reduced by the C172A mutant in YopJ.	Lysine	54-60	membrane associated ring-CH-type finger 8	Homo sapiens	12-18
28084329-3	2017	EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked polyUb chains onto hnRNP A1.	Lysine	171-177	elongin B	Homo sapiens	129-138
28324105-8	2017	At the Mc4r promoter, offspring of HFD-fed mothers demonstrated increased histone 3 lysine 27 acetylation (H3K27ac) with a greater association to thyroid hormone receptor-beta (TRbeta), an inhibitor of Mc4r transcription.	Lysine	84-90	melanocortin 4 receptor	Rattus norvegicus	7-11
34745943-4	2021	In this study, the results showed that LukS-PV induced apoptosis by downregulating the methyltransferase SET8 and its target histone H4 monomethylated at Lys 20 (H4K20me1).	Lysine	154-157	H4 clustered histone 6	Homo sapiens	125-135
34569575-2	2021	The peptides include the native fragment tau(9-16) (Ac-EVMEDHAG-NH2), and the Gln/Lys and Tyr/Ala mutated peptides (Ac-KGGYTMHK-NH2 and Ac-KGGATMHK-NH2) of tau(26-33).	Lysine	82-85	microtubule associated protein tau	Homo sapiens	156-159
24895758-3	2014	The uptake of lysine (Lys) via the roots was not altered in loss-of-function mutants, in accordance with the minor expression of CAT1 in roots, but plants ectopically overexpressing CAT1 incorporated Lys at higher rates.	Lysine	200-203	catalase 1	Arabidopsis thaliana	182-186
24504678-9	2014	For ERCC2 Lys751Gln, individuals who carried the variant heterozygote Lys/Gln or homozygote Gln/Gln had a significantly increased bladder cancer risk, compared with the wild genotype Lys/Lys (OR=1.10, 95 % CI=1.03-1.18).	Lysine	10-13	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-9
34269483-5	2021	GDH1 degradation reduces intracellular alphaKG levels by more than half and decreases the activity of alphaKG-dependent lysine demethylases (KDMs).	Lysine	120-126	glutamate dehydrogenase 1	Homo sapiens	0-4
34644302-4	2021	Here, we mapped the known SIRT3/SIRT5-targeted lysine residues onto the recently solved TFP crystal structure which revealed that many of the target sites are involved in substrate channeling within the TFPalpha subunit.	Lysine	47-53	sirtuin 3	Mus musculus	26-31
28103616-3	2017	In the present study, we have investigated the ability of l-Lysine, which has been shown to act as a 5-HT4 receptor antagonist, to counteract in vitro and in vivo the stimulatory effect of 5-HT4R agonists on aldosterone production.	Lysine	58-66	5-hydroxytryptamine receptor 4	Homo sapiens	101-115
28103616-3	2017	In the present study, we have investigated the ability of l-Lysine, which has been shown to act as a 5-HT4 receptor antagonist, to counteract in vitro and in vivo the stimulatory effect of 5-HT4R agonists on aldosterone production.	Lysine	58-66	5-hydroxytryptamine receptor 4	Homo sapiens	189-195
28103616-4	2017	l-Lysine was found to inhibit aldosterone production induced by 5-HT and the 5-HT4R agonists BIMU8 from cultured human adrenocortical cells.	Lysine	0-8	5-hydroxytryptamine receptor 4	Homo sapiens	77-83
24797066-1	2014	An active site lysine essential to catalysis in isocitrate dehydrogenase (IDH) is absent from related enzymes.	Lysine	15-21	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-72
27882480-13	2017	Early initiation of lysine-restricted diet and/or arginine therapy likely improved neurodevelopmental outcome in young patients with PDE-ALDH7A1.	Lysine	20-26	aldehyde dehydrogenase 7 family member A1	Homo sapiens	133-144
34332952-0	2021	Site-specific acetylation of adenine nucleotide translocase 1 at lysine 23 in human muscle.	Lysine	65-71	solute carrier family 25 member 4	Homo sapiens	29-61
34332952-1	2021	Evidence suggests acetylation of human adenine nucleotide translocase 1 (ANT1) at lysine 23 (Lys23) reduces binding of ADP.	Lysine	82-88	solute carrier family 25 member 4	Homo sapiens	39-71
34332952-1	2021	Evidence suggests acetylation of human adenine nucleotide translocase 1 (ANT1) at lysine 23 (Lys23) reduces binding of ADP.	Lysine	82-88	solute carrier family 25 member 4	Homo sapiens	73-77
28188227-8	2017	Deletion of Erap1 was permissive for the AS-like phenotype, increased mean peptide length and increased the frequency of C-terminal hydrophobic residues and of N-terminal Ala, Ser, or Lys.	Lysine	184-187	endoplasmic reticulum aminopeptidase 1	Rattus norvegicus	12-17
28188227-9	2017	The presence of Erap1 increased the frequency of C-terminal Lys and Arg, of Glu and Asp at intermediate residues, and of N-terminal Gly.	Lysine	60-63	endoplasmic reticulum aminopeptidase 1	Rattus norvegicus	16-21
24797066-1	2014	An active site lysine essential to catalysis in isocitrate dehydrogenase (IDH) is absent from related enzymes.	Lysine	15-21	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	74-77
24813891-4	2014	Upon Mll1 deletion, histone H4 lysine 16 (H4K16) acetylation is selectively depleted at MLL1 target genes in conjunction with reduced transcription.	Lysine	31-37	lysine methyltransferase 2A	Homo sapiens	5-9
28135235-2	2017	The catalytic subunit EZH2 methylates histone H3 lysine 27 (H3K27), and its activity is further enhanced by the binding of EED to trimethylated H3K27 (H3K27me3).	Lysine	49-55	embryonic ectoderm development	Homo sapiens	123-126
34396440-3	2021	The inhibition of WNK lysine deficient protein kinase/STE20/SPS1-related proline/alanine-rich kinase (SPAK) signaling ameliorates cerebral edema, and this signaling pathway regulates the phosphorylation of the downstream Na+-K+-Cl- cotransporter 1 (NKCC1).	Lysine	22-28	solute carrier family 12 member 2	Homo sapiens	249-254
28345603-6	2017	Further, the polyubiquitin chain conjugated to Tat by PJA2 can itself be assembled through variable ubiquitin lysine linkages.	Lysine	110-116	praja ring finger ubiquitin ligase 2	Homo sapiens	54-58
24813891-4	2014	Upon Mll1 deletion, histone H4 lysine 16 (H4K16) acetylation is selectively depleted at MLL1 target genes in conjunction with reduced transcription.	Lysine	31-37	lysine methyltransferase 2A	Homo sapiens	88-92
24692540-7	2014	At the core of alphaV-Fab interface were interactions involving Propeller residues Lys-203 and Gln-145, with the latter accounting for primate specificity.	Lysine	83-86	FA complementation group B	Homo sapiens	22-25
34517264-11	2021	Moreover, the inhibition of EZH2 by F2C led to Wnt/beta-catenin signaling inhibition by decreasing tri-methylation of histone H3 at lysine 27 (H3K27me3) and long non-coding RNA H19 expression.	Lysine	132-138	catenin beta 1	Homo sapiens	51-63
24733848-3	2014	The bromodomain and extraterminal (BET) proteins, Brd2, Brd3, Brd4, and BrdT, bind to acetylated lysine residues on histone or nonhistone proteins recruiting transcriptional regulators and thus activating or repressing gene transcription.	Lysine	97-103	bromodomain testis associated	Homo sapiens	72-76
34304093-4	2021	We identified the PLOD1 binding site in EBNA1as the N-terminal transactivation domain and show that lysine 83 is critical for this interaction.	Lysine	100-106	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	18-23
28304334-4	2017	Here, we show that hypoxia results in increased mRNA levels for human lysine (K)-specific demethylase 2 (KDM2) family members, KDM2A and KDM2B, and also for Drosophila melanogaster KDM2, a histone and protein demethylase.	Lysine	70-76	Lysine (K)-specific demethylase 2	Drosophila melanogaster	105-109
28300060-3	2017	Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on lysine 23/36/37 residues, which specifically recruits histone acetyltransferase GCN5 for subsequent H3 acetylation.	Lysine	104-110	lysine acetyltransferase 2A	Homo sapiens	184-188
24652292-4	2014	Its transport properties and kinetic parameters demonstrate that SLC25A29 transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine.	Lysine	95-101	solute carrier family 25 member 29	Homo sapiens	65-73
28301528-1	2017	A facultative heterochromatin mark, histone H3 lysine 9 dimethylation (H3K9me2), which is mediated by histone methyltransferases G9a/GLP (EHMT2/1), undergoes dramatic rearrangements during myeloid cell differentiation as observed by chromatin imaging.	Lysine	47-53	euchromatic histone lysine methyltransferase 2	Homo sapiens	129-136
28301528-1	2017	A facultative heterochromatin mark, histone H3 lysine 9 dimethylation (H3K9me2), which is mediated by histone methyltransferases G9a/GLP (EHMT2/1), undergoes dramatic rearrangements during myeloid cell differentiation as observed by chromatin imaging.	Lysine	47-53	euchromatic histone lysine methyltransferase 2	Homo sapiens	138-145
34587155-8	2021	Among GTFs, we found that TFIIF is a major target of sumoylation, specifically at lysines 60/61 of its Tfg1 subunit, and elevating Tfg1 sumoylation resulted in decreased interaction of TFIIF with RNAPII.	Lysine	82-89	transcription factor IIF subunit TFG1	Saccharomyces cerevisiae S288C	103-107
24646001-10	2014	Both acetylation (histone H4 pan-acetyl, histone H3 acetyl Lys 14) and methylation (histone H3 trimethyl Lys 9) marks were observed in the RPS27a promoter region, suggesting their important regulatory role in gene expression.	Lysine	59-62	ribosomal protein S27a	Homo sapiens	139-145
34895699-8	2021	We identified a robust increase specific to males in the expression of Kmt2a (histone-lysine N-methyltransferase 2A) that targets H3K4 (lysine 4 on histone H3) in cellular chromatin.	Lysine	136-142	lysine methyltransferase 2A	Homo sapiens	71-76
34895699-8	2021	We identified a robust increase specific to males in the expression of Kmt2a (histone-lysine N-methyltransferase 2A) that targets H3K4 (lysine 4 on histone H3) in cellular chromatin.	Lysine	136-142	lysine methyltransferase 2A	Homo sapiens	78-115
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Lysine	102-105	defensin beta 103B	Homo sapiens	109-114
28165227-3	2017	EED"s recognition of the product of PRC2 activity, histone H3 lysine 27 trimethylation (H3K27me3), stimulates PRC2 methyltransferase activity at adjacent nucleosomes leading to H3K27me3 propagation and, ultimately, gene repression.	Lysine	62-68	embryonic ectoderm development	Homo sapiens	0-3
28186757-2	2017	The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1).	Lysine	48-54	lysine demethylase 1A	Homo sapiens	80-85
28186757-2	2017	The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1).	Lysine	48-54	lysine demethylase 1A	Homo sapiens	87-91
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Lysine	102-105	defensin beta 103B	Homo sapiens	143-148
24646001-10	2014	Both acetylation (histone H4 pan-acetyl, histone H3 acetyl Lys 14) and methylation (histone H3 trimethyl Lys 9) marks were observed in the RPS27a promoter region, suggesting their important regulatory role in gene expression.	Lysine	105-108	ribosomal protein S27a	Homo sapiens	139-145
28115524-0	2017	P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA.	Lysine	52-58	prolyl 3-hydroxylase 3	Mus musculus	0-4
24631643-2	2014	In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24).	Lysine	122-125	proliferating cell nuclear antigen	Homo sapiens	20-24
28098854-7	2017	This is because the inhibition of LSD1 induces dimethylation of lysine 9 on histone H3 (H3K9m2) accumulation at the promoter region of cyclin D1.	Lysine	64-70	lysine demethylase 1A	Homo sapiens	34-38
28122963-5	2017	By repairing the deletion, we resurrected 11 alleles of KIR2DP1F , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1F with lysine 44 recognized C1+HLA-C, whereas T44-KIR2DP1F recognized C2+HLA-C.	Lysine	141-147	major histocompatibility complex, class I, C	Homo sapiens	165-170
34641382-4	2021	This article reports that d-ribose undergoes rapid protein glycation of human myoglobin (HMb) at lysine residues (K34, K87, K56, and K147) on the protein surface, as identified by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS).	Lysine	97-103	myoglobin	Homo sapiens	78-87
34530900-4	2021	RESULTS: Here, we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for the mono-methylation of histone H4 at lysine 20, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.	Lysine	55-61	H4 clustered histone 6	Homo sapiens	136-146
34530900-4	2021	RESULTS: Here, we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for the mono-methylation of histone H4 at lysine 20, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.	Lysine	150-156	H4 clustered histone 6	Homo sapiens	136-146
34530900-6	2021	Indeed, the inhibition of SETD8 by the chemical compound UNC-0379 and the subsequent decrease in histone H4 methylation at lysine 20 are highly toxic in MM cells compared to normal cells from the bone marrow microenvironment.	Lysine	123-129	H4 clustered histone 6	Homo sapiens	97-107
28122963-5	2017	By repairing the deletion, we resurrected 11 alleles of KIR2DP1F , the functional antecedent of KIR2DP1 We demonstrate how K44-KIR2DP1F with lysine 44 recognized C1+HLA-C, whereas T44-KIR2DP1F recognized C2+HLA-C.	Lysine	141-147	major histocompatibility complex, class I, C	Homo sapiens	207-212
24631643-2	2014	In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24).	Lysine	122-125	PCNA clamp associated factor	Homo sapiens	26-31
24631643-2	2014	In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24).	Lysine	134-137	proliferating cell nuclear antigen	Homo sapiens	20-24
28073915-8	2017	We extended the UbE2E1 regulation of uH2AK119 to USP7 and showed that USP7 is also a key regulator for monoubiquitination at H2A Lys-119 as both knockdown and deletion of USP7 results in decreased levels of uH2AK119.	Lysine	129-132	ubiquitin specific peptidase 7	Homo sapiens	70-74
28073915-8	2017	We extended the UbE2E1 regulation of uH2AK119 to USP7 and showed that USP7 is also a key regulator for monoubiquitination at H2A Lys-119 as both knockdown and deletion of USP7 results in decreased levels of uH2AK119.	Lysine	129-132	ubiquitin specific peptidase 7	Homo sapiens	70-74
24631643-2	2014	In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24).	Lysine	134-137	PCNA clamp associated factor	Homo sapiens	26-31
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	87-93	src homology 2 domain-containing transforming protein C1	Mus musculus	25-31
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	RAP1A, member of RAS oncogene family	Homo sapiens	35-39
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	87-93	src homology 2 domain-containing transforming protein C1	Mus musculus	165-171
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	RAP1A, member of RAS oncogene family	Homo sapiens	238-242
23686307-1	2014	Acetylation of the RelA subunit of NF-kappaB at lysine-310 regulates the transcriptional activation of NF-kappaB target genes and contributes to maintaining constitutively active NF-kappaB in tumors.	Lysine	48-54	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	19-23
34603379-6	2021	Based on the resolved structure of Rap1-Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap GTP.	Lysine	181-187	LDL receptor related protein associated protein 1	Homo sapiens	288-291
34496098-10	2021	LP+0.3% Lys group attenuated the effects of LP diet on the expression of MSTN, WWP1, IGF1, P-P70S6K1, P-4EBP1 and P-S6 (p < 0.05).	Lysine	8-11	insulin-like growth factor I	Oryctolagus cuniculus	85-89
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	87-93	src homology 2 domain-containing transforming protein C1	Mus musculus	165-171
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	214-220	src homology 2 domain-containing transforming protein C1	Mus musculus	25-31
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	214-220	src homology 2 domain-containing transforming protein C1	Mus musculus	165-171
28137876-8	2017	These findings show that p66Shc is a target of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidative function of p66Shc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic vascular pathophysiology.	Lysine	214-220	src homology 2 domain-containing transforming protein C1	Mus musculus	165-171
23686307-2	2014	Bromodomain-containing factor Brd4 has been shown to bind to acetylated lysine-310 (AcLys310) and to regulate the transcriptional activity of NF-kappaB, but the role of this binding in maintaining constitutively active NF-kappaB in tumors remains elusive.	Lysine	72-78	bromodomain containing 4	Mus musculus	30-34
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Lysine	237-243	solute carrier family 7 member 9	Homo sapiens	108-114
34489420-6	2021	These results clarify steps required for ERAP1 catalysis, demonstrate the importance of conformational dynamics within the catalytic cycle, and provide a mechanism for the observed allosteric regulation and Lys/Arg528 polymorphism disease association.	Lysine	207-210	endoplasmic reticulum aminopeptidase 1	Homo sapiens	41-46
24704205-7	2014	Considering this lysine site is conserved among a wide range of species and other related cyclin-dependent kinases, therefore, we speculate that acetylation may alter the kinase activity of CDK5 via affecting efficacy of ATP coordination.	Lysine	17-23	cyclin dependent kinase 5	Homo sapiens	190-194
28069388-7	2017	Renal tissues of VDR-M mice showed acetylation of p53 at lysine (K) 382 residues inferring that enhanced p53 expression in renal tissues could be the result of ongoing acetylation, a consequence of SIRT1 deficient state.	Lysine	57-63	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	17-20
24563466-6	2014	Nuclear localization of OGT affects O-GlcNAcylation of numerous nuclear proteins and acetylation of Lys-9 on histone 3 in myotubes.	Lysine	100-103	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	24-27
28380621-13	2017	1 indicated that the SID of His, Lys, and Thr tended ( &lt; 0.10) to be greater in SPC ground to 180 mum than in soybean meal, and the SID of Arg, Ile, Phe, and Trp was greater ( &lt; 0.05) in SPC ground to 70 or 180 mum than in soybean meal.	Lysine	33-36	surfactant protein C	Sus scrofa	83-86
34085165-7	2021	In addition, incubation of  2-HDE with rHDAC1 generated five different amino acid adducts as detected by LC-MS/MS; the predominant adduct being  2-HDE with lysine residues of HDAC1.	Lysine	156-162	histone deacetylase 1	Mus musculus	175-180
34119876-7	2021	Mechanistically, SAHH inhibition increased TXNIP by inhibiting histone methyltransferase enhancer of zeste homolog 2 (EZH2) and reduced trimethylation of histone H3 lysine 27 and its enrichment at promoter of early growth response 1 (EGR1).	Lysine	165-171	S-adenosylhomocysteine hydrolase	Mus musculus	17-21
24567338-9	2014	Thus, RetGC1 activation by GCAP1 involves establishing a tight complex through the binding patch with an additional activation step involving Met-26, Lys-85, and Trp-94.	Lysine	150-153	guanylate cyclase 2D, retinal	Homo sapiens	6-12
34119876-7	2021	Mechanistically, SAHH inhibition increased TXNIP by inhibiting histone methyltransferase enhancer of zeste homolog 2 (EZH2) and reduced trimethylation of histone H3 lysine 27 and its enrichment at promoter of early growth response 1 (EGR1).	Lysine	165-171	early growth response 1	Mus musculus	209-232
34119876-7	2021	Mechanistically, SAHH inhibition increased TXNIP by inhibiting histone methyltransferase enhancer of zeste homolog 2 (EZH2) and reduced trimethylation of histone H3 lysine 27 and its enrichment at promoter of early growth response 1 (EGR1).	Lysine	165-171	early growth response 1	Mus musculus	234-238
28147277-4	2017	Mechanistically, SIRT7 specifically interacts with and deacetylates FKBP51 at residue lysines 28 and 155 (K28 and K155), resulting in enhanced interactions among FKBP51, Akt, and PHLPP, as well as Akt dephosphorylation.	Lysine	86-93	sirtuin 7	Mus musculus	17-22
28147277-4	2017	Mechanistically, SIRT7 specifically interacts with and deacetylates FKBP51 at residue lysines 28 and 155 (K28 and K155), resulting in enhanced interactions among FKBP51, Akt, and PHLPP, as well as Akt dephosphorylation.	Lysine	86-93	FK506 binding protein 5	Mus musculus	68-74
28147277-4	2017	Mechanistically, SIRT7 specifically interacts with and deacetylates FKBP51 at residue lysines 28 and 155 (K28 and K155), resulting in enhanced interactions among FKBP51, Akt, and PHLPP, as well as Akt dephosphorylation.	Lysine	86-93	FK506 binding protein 5	Mus musculus	162-168
28147277-4	2017	Mechanistically, SIRT7 specifically interacts with and deacetylates FKBP51 at residue lysines 28 and 155 (K28 and K155), resulting in enhanced interactions among FKBP51, Akt, and PHLPP, as well as Akt dephosphorylation.	Lysine	86-93	PH domain and leucine rich repeat protein phosphatase 1	Mus musculus	179-184
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Lysine	14-21	sirtuin 7	Mus musculus	59-64
34419497-3	2021	We found that AKT transcription signaling was a target pathway via miR-26a-mediated deacetylation modification of Ras-responsive element-binding protein 1 (RREB1) at the Lys-60 residue.	Lysine	170-173	ras responsive element binding protein 1	Homo sapiens	114-154
34419497-3	2021	We found that AKT transcription signaling was a target pathway via miR-26a-mediated deacetylation modification of Ras-responsive element-binding protein 1 (RREB1) at the Lys-60 residue.	Lysine	170-173	ras responsive element binding protein 1	Homo sapiens	156-161
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Lysine	14-21	FK506 binding protein 5	Mus musculus	89-95
23384296-10	2014	These results indicated that exogenous NAD(+) supplementation attenuated HR-induced cell apoptosis, which was at least partly mediated by restoring Sirt1 activity and subsequently inhibiting p53 activity via deacetylating p53 at lysine 373 and 382.	Lysine	229-235	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	222-225
34411416-7	2022	Using the EXP2 nanopore allowed us to detect poly-L-lysine (PLL) at a single-molecule level.	Lysine	45-58	chromosome segregation 1 like	Homo sapiens	10-14
24582286-0	2014	Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures.	Lysine	0-6	heat shock protein family A (Hsp70) member 14	Homo sapiens	53-77
34242003-6	2021	By examining the association and uptake efficiencies of IL2 molecules that are biotinylated via either random lysine-targeting chemical reaction (using NHS-PEG4-Biotin) or site-specific enzymatic modification (using Avitag sequence), we demonstrated that the most efficient delivery of cargo can be achieved by C-terminal conjugation.	Lysine	110-116	interleukin 2	Mus musculus	56-59
34242003-6	2021	By examining the association and uptake efficiencies of IL2 molecules that are biotinylated via either random lysine-targeting chemical reaction (using NHS-PEG4-Biotin) or site-specific enzymatic modification (using Avitag sequence), we demonstrated that the most efficient delivery of cargo can be achieved by C-terminal conjugation.	Lysine	110-116	small nuclear ribonucleoprotein N	Mus musculus	156-160
27733505-4	2017	Mechanistically, the TET1 facilitated chromatin affinity and enzymatic activity of hMOF against acetylation of histone H4 at lysine 16 via preventing auto-acetylation of hMOF, to regulate expression of the downstream genes, including DNA repair genes.	Lysine	125-131	tet methylcytosine dioxygenase 1	Mus musculus	21-25
28099510-5	2017	Instead of promoting the conjugation of polyubiquitin chains and the subsequent proteasomal degradation of NUB1, Mdm2 rather induces its di-ubiquitination on lysine 159.	Lysine	158-164	MDM2 proto-oncogene	Homo sapiens	113-117
28099510-7	2017	We conclude that Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159.	Lysine	106-112	MDM2 proto-oncogene	Homo sapiens	17-21
28099510-7	2017	We conclude that Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159.	Lysine	106-112	negative regulator of ubiquitin like proteins 1	Homo sapiens	54-58
28099510-7	2017	We conclude that Mdm2 acts as a positive regulator of NUB1 function, by modulating NUB1 ubiquitination on lysine 159.	Lysine	106-112	negative regulator of ubiquitin like proteins 1	Homo sapiens	83-87
34266235-0	2021	Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9.	Lysine	7-10	proprotein convertase subtilisin/kexin type 9	Homo sapiens	55-60
24492612-4	2014	Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner.	Lysine	70-76	KMT5A pseudogene 1	Homo sapiens	153-157
24408033-8	2014	Substituting the three lysine residues in this region of Snl1-M with alanine restores ability to cure [URE3].	Lysine	23-29	Snl1p	Saccharomyces cerevisiae S288C	57-63
28017215-4	2017	Consistently with sirtuin 1 role in controlling acetylation status, we observed a substantial reduction of the acetylation on histone 3 lysine 9, associated with gene transcription in the AD twin.	Lysine	136-142	sirtuin 1	Homo sapiens	18-27
24651376-8	2014	ATBF1 SUMOylation occurred at more than 3 lysine residues including K2349, K2806 and K3258 and was nuclear specific.	Lysine	42-48	zinc finger homeobox 3	Homo sapiens	0-5
28060933-9	2017	This depends only on the self-reinforcing loop between CHROMOMETHYLASE 3 and KRYPTONITE, involving DNA methylated in the CHG context and histone H3 lysine 9 methylation.	Lysine	148-154	chromomethylase 3	Arabidopsis thaliana	55-72
27939640-8	2017	Functional assays showed that the resulting BRPF1 variants are pathogenic and impair acetylation of histone H3 at lysine 23, an abundant but poorly characterized epigenetic mark.	Lysine	114-120	bromodomain and PHD finger containing 1	Homo sapiens	44-49
34320252-3	2021	Here, we review CFP1"s functions and its impact on DNA methylation and the post-translational modification of histone proteins such as lysine acetylation and methylation.	Lysine	135-141	CXXC finger protein 1	Homo sapiens	16-20
34361805-1	2021	The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine demethylation and lysine hydroxylation of histone and a growing list of its known substrate molecules, including p53 and U2AF65, suggesting a possible role in mRNA splicing and transcription in cancer progression.	Lysine	94-100	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	4-39
34361805-1	2021	The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine demethylation and lysine hydroxylation of histone and a growing list of its known substrate molecules, including p53 and U2AF65, suggesting a possible role in mRNA splicing and transcription in cancer progression.	Lysine	94-100	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	41-46
24426167-8	2014	Transcript analysis of candidate innate immune gene (clec-60, clec-87, lys-7, ilys-3, scl-2, cpr-2, F08G5.6, atf-7, age-1, bec-1 and daf-16) regulations in the host during S. Typhi infection have been assessed through qPCR analysis to understand the activation of immune signaling pathways during S. Typhi infections.	Lysine	14-17	C-type lectin domain-containing protein 87	Caenorhabditis elegans	62-69
34290256-4	2021	Among these are RNF20 and RNF40, which form a complex that monoubiquitinates H2B on lysine 120.	Lysine	84-90	H2B clustered histone 21	Homo sapiens	77-80
27270439-2	2017	Here we identified that the lysine-specific demethylase KDM3A played a dual role in breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, respectively.	Lysine	28-34	lysine demethylase 3A	Homo sapiens	56-61
27931518-5	2017	Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in the regulatory elements of the Il17 locus, and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2).	Lysine	59-65	lysine demethylase 4A	Homo sapiens	184-221
34244427-7	2021	Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation.	Lysine	169-175	homeodomain interacting protein kinase 2	Mus musculus	17-22
34244427-7	2021	Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation.	Lysine	169-175	histone deacetylase 3	Mus musculus	48-69
24111946-0	2014	Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.	Lysine	28-34	REST corepressor 1	Homo sapiens	134-140
34244427-7	2021	Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation.	Lysine	169-175	histone deacetylase 3	Mus musculus	71-76
34244427-7	2021	Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation.	Lysine	169-175	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	162-165
27983522-1	2017	OBJECTIVE: UTX and JMJD3 are recently identified histone H3 lysine 27 (H3K27) demethylases.	Lysine	60-66	lysine demethylase 6B	Homo sapiens	19-24
27174055-1	2017	BACKGROUND: G9a is the primary enzyme for mono- and dimethylation at Lys 9 of histone H3 and forms predominantly the heteromeric complex as a G9a-GLP (G9a-like protein) that is a functional histone lysine methltransferase in vivo.	Lysine	69-72	euchromatic histone lysine methyltransferase 2	Homo sapiens	12-15
23435422-0	2014	MYC activity is negatively regulated by a C-terminal lysine cluster.	Lysine	53-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
27174055-1	2017	BACKGROUND: G9a is the primary enzyme for mono- and dimethylation at Lys 9 of histone H3 and forms predominantly the heteromeric complex as a G9a-GLP (G9a-like protein) that is a functional histone lysine methltransferase in vivo.	Lysine	69-72	euchromatic histone lysine methyltransferase 2	Homo sapiens	142-145
27174055-1	2017	BACKGROUND: G9a is the primary enzyme for mono- and dimethylation at Lys 9 of histone H3 and forms predominantly the heteromeric complex as a G9a-GLP (G9a-like protein) that is a functional histone lysine methltransferase in vivo.	Lysine	69-72	euchromatic histone lysine methyltransferase 2	Homo sapiens	142-145
34335974-5	2021	Depletion of mdig in bronchial epithelial cells by CRISPR-Cas-9 gene editing resulted in a decreased expression of NRP1, NRP2, cathepsins, and genes involved in protein glycosylation and inflammation, largely due to a substantial enrichment of lysine 9 and/or lysine 27 trimethylation of histone H3 (H3K9me3/H3K27me3) on these genes as determined by ChIP-seq.	Lysine	244-250	ribosomal oxygenase 2	Homo sapiens	13-17
34335974-5	2021	Depletion of mdig in bronchial epithelial cells by CRISPR-Cas-9 gene editing resulted in a decreased expression of NRP1, NRP2, cathepsins, and genes involved in protein glycosylation and inflammation, largely due to a substantial enrichment of lysine 9 and/or lysine 27 trimethylation of histone H3 (H3K9me3/H3K27me3) on these genes as determined by ChIP-seq.	Lysine	260-266	ribosomal oxygenase 2	Homo sapiens	13-17
23435422-5	2014	In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR).	Lysine	91-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-59
34217333-3	2021	To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b+/-) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity.	Lysine	156-162	KDM3B lysine (K)-specific demethylase 3B	Mus musculus	105-110
34217333-3	2021	To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b+/-) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity.	Lysine	156-162	KDM3B lysine (K)-specific demethylase 3B	Mus musculus	121-126
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	H3 histone pseudogene 16	Homo sapiens	53-56
27657733-10	2017	Among these, PR-domain zinc-finger protein 2, a methyltransferase that selectively mono-methylates histone H3 at lysine 9 has been functionally validated to drive several of the molecular and behavioral long-term consequences of alcohol dependence.	Lysine	113-119	PR/SET domain 2	Homo sapiens	13-44
28396876-0	2017	Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.	Lysine	19-25	lysine demethylase 4C	Homo sapiens	142-147
23435422-5	2014	In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR).	Lysine	91-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-136
28396876-11	2017	The expression of histone methyltransferase SUV39H2 for H3 lysine 9 methylation was downregulated in LADA patients, and the expression of histone demethylase KDM4C which made H3 lysine 9 demethylation was upregulated.	Lysine	59-65	lysine demethylase 4C	Homo sapiens	158-163
23435422-10	2014	Combined, our data identify this region and these six lysines as important residues for the negative regulation of MYC-induced transformation.	Lysine	54-61	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-118
28396876-11	2017	The expression of histone methyltransferase SUV39H2 for H3 lysine 9 methylation was downregulated in LADA patients, and the expression of histone demethylase KDM4C which made H3 lysine 9 demethylation was upregulated.	Lysine	178-184	lysine demethylase 4C	Homo sapiens	158-163
28396876-13	2017	The reduction of histone H3 lysine 9 methylation which may due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C was found in CD4+ T lymphocytes of LADA patients.	Lysine	28-34	lysine demethylase 4C	Homo sapiens	150-155
24486017-3	2014	Here, we report that lysine acetylation of PDHA1 and PDP1 is common in epidermal growth factor (EGF)-stimulated cells and diverse human cancer cells.	Lysine	21-27	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	43-48
27879032-4	2017	We observed that Brahma-related gene 1 (BRG1) and Lysine demethylase 1A (KDM1A), which can alter the methylation status of lysine 4 in histone 3 (H3K4), localize to the nucleus at Day 3-4 of development.	Lysine	123-129	lysine demethylase 1A	Homo sapiens	73-78
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	H3 histone pseudogene 16	Homo sapiens	154-157
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	H3 histone pseudogene 16	Homo sapiens	216-219
34105888-10	2021	Mechanistically, LINC00525 epigenetically suppressed p21 transcription by guiding Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) to the p21 promoter through an formation of RNA-DNA triplex with the p21 promoter, leading to increased trimethylation of lysine 27 on histone 3 (H3K27me3) of the p21 promoter.	Lysine	269-275	H3 histone pseudogene 16	Homo sapiens	310-313
24200862-8	2014	The external aldimine of kynurenine and PLP is then deprotonated by the epsilon-amino group of Lys-227 to give a quinonoid intermediate, which is reprotonated at C-4" to give a ketimine.	Lysine	95-98	complement C4A (Rodgers blood group)	Homo sapiens	162-165
34157286-6	2021	Using recombinant single-isotype tubulin, we demonstrated that methylation was restricted to lysine 40 (K40) of alpha-tubulin.	Lysine	93-99	tubulin alpha 1b	Homo sapiens	112-125
27920160-6	2017	In mom1-3 ovules, both SUF4 and EC1 genes are down-regulated, and EC1 genes show higher levels of histone 3 lysine-9 acetylation, suggesting that MOM1 contributes to the regulation of SUF4 and EC1 gene expression.	Lysine	108-114	ATP-dependent helicase family protein	Arabidopsis thaliana	146-150
24502362-8	2014	Mechanistically, the abnormal E2F1 motif methylation-mediated loss of active histone H3 lysine 9 acetylation (H3K9ac) and transcription factor E2F1 enrichment synergistically inhibited the transcription of DNMT1.	Lysine	88-94	E2F transcription factor 1	Homo sapiens	30-34
27836964-4	2016	We further show that D6PK directly binds polyacidic phospholipids through a polybasic lysine-rich motif in the middle domain of the kinase.	Lysine	86-92	D6 protein kinase	Arabidopsis thaliana	21-25
34168076-5	2021	Methylation of lysine residue 27 (H3K27me3) of the deposited H3.1/3.2 in the paternal perinucleolar region caused this delay in DNA replication.	Lysine	15-21	H3 clustered histone 3	Homo sapiens	61-69
24516652-0	2014	ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4.	Lysine	65-71	Imitation SWI	Drosophila melanogaster	0-4
34103516-7	2021	Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation.	Lysine	153-159	heat shock transcription factor A3	Arabidopsis thaliana	67-72
27643486-2	2016	Lysine 9 of histone H3 (H3K9) is subject to PTMs, such as methylation and acetylation, which influence histone activity during spermatogenesis.	Lysine	0-6	histocompatibility 3	Mus musculus	20-22
24291127-2	2014	Each KMT2A-E contains a catalytic SET domain that methylates lysine 4 of histone H3, and one or several PHD fingers.	Lysine	61-67	lysine methyltransferase 2A	Homo sapiens	5-10
27810556-3	2016	In the present study, we developed liposomes functionalized with lysine and polyoxyethylene stearate conjugate (LPS) to interact with ATB0,+, an amino acid transporter overexpressed in hepatocarcinoma and the liver cancer cell line HepG2.	Lysine	65-71	solute carrier family 1 member 5	Homo sapiens	134-138
27682507-2	2016	A co-crystal structure of a ligand-efficient screening hit and the CBP bromodomain guided initial design targeting the LPF shelf, ZA loop, and acetylated lysine binding regions.	Lysine	154-160	CREB binding protein	Mus musculus	67-70
34065652-4	2021	Proteomics studies have identified lysine acetylation in WT IDH1, indicating post-translational regulation.	Lysine	35-41	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	60-64
34065652-5	2021	Here, we generated lysine to glutamine acetylation mimic mutants in IDH1 to evaluate the effects on activity.	Lysine	19-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	68-72
34065652-6	2021	We show that mimicking lysine acetylation decreased the catalytic efficiency of WT IDH1, with less severe catalytic consequences for R132H IDH1.	Lysine	23-29	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	83-87
34306972-1	2021	The trimethylation on histone H3 lysine 27 (H3k27me3), a transcriptionally repressive epigenetic mark of permissive chromatin, can be removed by the histone lysine demethylase 6a (Kdm6a).	Lysine	33-39	lysine (K)-specific demethylase 6A	Mus musculus	180-185
27528513-1	2016	As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition of JMJD3 may attenuate autoimmune disorders.	Lysine	49-55	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	108-113
27528513-1	2016	As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition of JMJD3 may attenuate autoimmune disorders.	Lysine	49-55	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	206-211
24382305-8	2014	Human NEIL1 is known to undergo editing whereby the lysine at position 242 is recoded into an arginine.	Lysine	52-58	nei like DNA glycosylase 1	Homo sapiens	6-11
27528513-1	2016	As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition of JMJD3 may attenuate autoimmune disorders.	Lysine	80-86	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	108-113
27528513-1	2016	As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition of JMJD3 may attenuate autoimmune disorders.	Lysine	80-86	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	206-211
27880901-6	2016	However, GCN2-deficient CD8+ T cells fail to proliferate in limiting tryptophan, arginine, leucine, lysine, or asparagine, the opposite of what previous studies concluded.	Lysine	100-106	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	9-13
34401209-7	2021	The effects of lncRNA H19 on hDPSCs were achieved by repressing LATS1 through enhancer of zeste homolog 2-induced trimethylation of histone 3 at lysine 27.	Lysine	145-151	H19 imprinted maternally expressed transcript	Homo sapiens	22-25
34401209-7	2021	The effects of lncRNA H19 on hDPSCs were achieved by repressing LATS1 through enhancer of zeste homolog 2-induced trimethylation of histone 3 at lysine 27.	Lysine	145-151	large tumor suppressor kinase 1	Homo sapiens	64-69
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	55-61	sirtuin 3	Mus musculus	39-44
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	SKI proto-oncogene	Homo sapiens	199-202
35579947-5	2022	Mechanistically, hnRNPA1 bound with SUMO2 at the lysine 113 residue via KRASG12D-induced hyperactivation of SUMOylation, which enabled its interaction with TSG101 to enhance hnRNPA1 packaging and transmission via EVs.	Lysine	49-55	tumor susceptibility 101	Homo sapiens	156-162
27874088-3	2016	Euchromatic histone-lysine N-methyltransferase 2, also known as G9a, methylates histone H3 on lysine residue 9 to predominantly produce a dynamic histone dimethylation, resulting in condensed chromatin and gene transcriptional repression.	Lysine	20-26	euchromatic histone lysine methyltransferase 2	Homo sapiens	64-67
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	98-104	sirtuin 3	Mus musculus	39-44
24709419-6	2014	Our data further show that SMURF2 monoubiquitinates UBCH5 at lysine 144 to form an active complex required for efficient degradation of a RAS-family E3, beta-transducing repeat containing protein 1 (beta-TrCP1).	Lysine	61-67	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	153-197
27634040-1	2016	Lysine demethylation of proteins such as histones is catalyzed by several classes of enzymes, including the FAD-dependent amine oxidases KDM1A/B.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	137-144
27758858-3	2016	Previous work has demonstrated that Ezh2 (enhancer of zeste homolog 2), a histone 3 lysine 27 (H3K27) methyltransferase, suppressed differentiation of osteogenic progenitors.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	36-40
35257729-6	2022	It is suggested that increasing the structural stability of Tau protein limits the ability of this protein for DNA binding, while the molecular and physical barrier of glycated Lys residues should not be neglected.	Lysine	177-180	microtubule associated protein tau	Homo sapiens	60-63
35446032-4	2022	Luminal targeting of seed particles occurs through covalently linked Fab fragments of an antibody recognizing the acetylated lysine 40 on the luminal side of alpha-tubulin.	Lysine	125-131	FA complementation group B	Homo sapiens	69-72
35446032-4	2022	Luminal targeting of seed particles occurs through covalently linked Fab fragments of an antibody recognizing the acetylated lysine 40 on the luminal side of alpha-tubulin.	Lysine	125-131	tubulin alpha 1b	Homo sapiens	158-171
27758858-3	2016	Previous work has demonstrated that Ezh2 (enhancer of zeste homolog 2), a histone 3 lysine 27 (H3K27) methyltransferase, suppressed differentiation of osteogenic progenitors.	Lysine	84-90	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	42-69
24709419-6	2014	Our data further show that SMURF2 monoubiquitinates UBCH5 at lysine 144 to form an active complex required for efficient degradation of a RAS-family E3, beta-transducing repeat containing protein 1 (beta-TrCP1).	Lysine	61-67	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	199-209
24234436-2	2014	Herein, we found that upstream binding factor (UBF) interacts with ESET, a histone H3K9 methyltransferase and is trimethylated at Lys (K) 232/254 by ESET.	Lysine	130-133	upstream binding transcription factor	Homo sapiens	22-45
27824159-5	2016	D-2HG, but not L-2HG, increased the trimethylation of histone H3 lysine 4 of the promoter region of ZEB1, a master regulator of epithelial-mesenchymal transition (EMT), and increased the expression of the ZEB1 gene to directly induce EMT in colorectal cancer cells.	Lysine	65-71	zinc finger E-box binding homeobox 1	Homo sapiens	100-104
35158021-9	2022	Mechanistically, SIRT1 interacts with heat shock 70 kDa protein 4 (HSPA4) and deacetylates it at 305, 351 and 605 lysine residues.	Lysine	114-120	sirtuin 1	Mus musculus	17-22
24234436-2	2014	Herein, we found that upstream binding factor (UBF) interacts with ESET, a histone H3K9 methyltransferase and is trimethylated at Lys (K) 232/254 by ESET.	Lysine	130-133	upstream binding transcription factor	Homo sapiens	47-50
28357218-5	2014	This conformation of the tail was associated with reduced tri-methylation on histone H3 lysine 4 (H3K4me3) due to both decreased methylation by the Set1 methyltransferase (with the me3-specific subunit Spp1) and increased demethylation by the demethylase Jhd2.	Lysine	88-94	secreted phosphoprotein 1	Homo sapiens	202-206
35462170-6	2022	We found increased histone 3 lysine 4 trimethylation (H3K4me3) enrichment at multiple MLL1 binding sites upon LPS stimulation, a known inducer of IgM.	Lysine	29-35	lysine methyltransferase 2A	Homo sapiens	86-90
27498087-5	2016	HECW2 physically interacts with AMOTL1 and enhances its stability via lysine 63-linked ubiquitination.	Lysine	70-76	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	Homo sapiens	0-5
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	42-45	KRAS proto-oncogene, GTPase	Homo sapiens	66-72
24443924-11	2014	However, XPD Lys751Gln polymorphism was significantly associated with susceptibility to LC and NPC and the Lys allele and Lys/Lys genotype of XPD Lys751Gln polymorphism may be a risk factor for LC and NPC.	Lysine	13-16	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	9-12
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	42-45	KRAS proto-oncogene, GTPase	Homo sapiens	131-137
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	50-53	KRAS proto-oncogene, GTPase	Homo sapiens	66-72
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	50-53	KRAS proto-oncogene, GTPase	Homo sapiens	131-137
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	50-53	KRAS proto-oncogene, GTPase	Homo sapiens	66-72
27791178-7	2016	We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may enable PDEdelta to bind both forms of prenylated KRAS4b.	Lysine	50-53	KRAS proto-oncogene, GTPase	Homo sapiens	131-137
35572636-6	2022	Results: Mice lacking CYP1A1 exhibited an altered gut microbiome, a reduced metabolic shift from lysine to cadaverine in the caecal contents and antimicrobial molecule production (Retnlb, Gbp7, and Gbp3), and they were protected against gut barrier disruption when subjected to MRSA challenge.	Lysine	97-103	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	22-28
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	142-150	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
24379373-6	2014	Upon viral infection, TRIM14 undergoes Lys-63-linked polyubiquitination at Lys-365 and recruits NF-kappaB essential modulator to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3 and NF-kappaB pathways.	Lysine	39-42	mitochondrial antiviral signaling protein	Homo sapiens	133-137
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	142-150	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	152-155	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	152-155	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
27705745-4	2016	In mouse embryonic stem cells, RYBP plays a central role in shaping H2AK119 mono-ubiquitylation at PcG targets and underpins an activity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required for normal histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	251-257	RING1 and YY1 binding protein	Mus musculus	31-35
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	164-167	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
24379373-6	2014	Upon viral infection, TRIM14 undergoes Lys-63-linked polyubiquitination at Lys-365 and recruits NF-kappaB essential modulator to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3 and NF-kappaB pathways.	Lysine	75-78	tripartite motif containing 14	Homo sapiens	22-28
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Lysine	164-167	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
27595303-2	2016	MIL38 antibody, a mouse monoclonal antibody against Glypican 1, conjugated directly to the chelate via lysine residues, resulted in soluble (hydrophilic) and stable immunoconjugates.	Lysine	103-109	glypican 1	Homo sapiens	52-62
35563125-3	2022	In humans, pharmacological hArg is metabolized to Lys.	Lysine	50-53	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	27-31
24333447-0	2014	Prostaglandin receptor EP1-mediated differential degradation of cyclooxygenases involves a specific lysine residue.	Lysine	100-106	prostaglandin E receptor 1	Homo sapiens	23-26
35563125-9	2022	Our results suggest that Lys and Arg are major metabolites of pharmacological hArg.	Lysine	25-28	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	78-82
35563127-3	2022	Many recent studies have been directed at understanding the role of methylated lysine 20 of histone H4 (H4K20) in physiological and pathological processes.	Lysine	79-85	H4 clustered histone 6	Homo sapiens	92-102
27698494-9	2016	Additionally, we identify lysine residues at positions 152 and 154 in the N-terminal domain of ORF50 critically involved in MDM2-mediated downregulation of ORF50 levels.	Lysine	26-32	ORF50	Human gammaherpesvirus 8	95-100
27698494-9	2016	Additionally, we identify lysine residues at positions 152 and 154 in the N-terminal domain of ORF50 critically involved in MDM2-mediated downregulation of ORF50 levels.	Lysine	26-32	MDM2 proto-oncogene	Homo sapiens	124-128
27698494-9	2016	Additionally, we identify lysine residues at positions 152 and 154 in the N-terminal domain of ORF50 critically involved in MDM2-mediated downregulation of ORF50 levels.	Lysine	26-32	ORF50	Human gammaherpesvirus 8	156-161
35442561-4	2022	PPD significantly decreased RBBP4-dependent trimethylation at lysine 27 of histone H3 (H3K27me3), a crucial epigenetic marker that correlates with histologic signs of colorectal cancer aggressiveness, and PPD inhibition of proliferation and migration of HCT116 cells was antagonized by RBBP4 RNA silencing.	Lysine	62-68	RB binding protein 4, chromatin remodeling factor	Homo sapiens	28-33
24333447-4	2014	Here we show that the sensitivity of both COX-1 and COX-2 to EP1 is altered upon modification of one lysine residue.	Lysine	101-107	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	42-47
24333447-4	2014	Here we show that the sensitivity of both COX-1 and COX-2 to EP1 is altered upon modification of one lysine residue.	Lysine	101-107	prostaglandin E receptor 1	Homo sapiens	61-64
35404406-6	2022	KMT5C catalyzed trimethylation of histone H4 lysine 20 (H4K20), a modification required for gene repression and maintenance of heterochromatin.	Lysine	45-51	lysine methyltransferase 5C	Homo sapiens	0-5
27466427-13	2016	The lysine residues and the ubiquitination of BFRF1 regulate the formation of BFRF1-induced NE-derived vesicles and EBV maturation.	Lysine	4-10	nuclear egress membrane protein	Human gammaherpesvirus 4	78-83
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Lysine	20-26	prostaglandin E receptor 1	Homo sapiens	119-122
24235145-0	2014	Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.	Lysine	160-166	lysine methyltransferase 2A	Homo sapiens	38-62
27661449-3	2016	This function of Pask is dependent upon its ability to phosphorylate Wdr5, a member of several protein complexes including those that catalyze histone H3 Lysine 4 trimethylation (H3K4me3) during transcriptional activation.	Lysine	154-160	PAS domain containing serine/threonine kinase	Homo sapiens	17-21
24235145-0	2014	Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.	Lysine	160-166	lysine methyltransferase 2A	Homo sapiens	64-68
24235145-1	2014	The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias.	Lysine	114-120	lysine methyltransferase 2A	Homo sapiens	4-28
27226494-1	2016	Enhancer of zeste homolog 2 (EZH2) trimethylates histone H3 Lys 27 and plays key roles in a variety of biological processes.	Lysine	60-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
24235145-1	2014	The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias.	Lysine	114-120	lysine methyltransferase 2A	Homo sapiens	30-34
27226494-1	2016	Enhancer of zeste homolog 2 (EZH2) trimethylates histone H3 Lys 27 and plays key roles in a variety of biological processes.	Lysine	60-63	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
35380918-4	2022	In this study, we showed that TRAF6 mediates oxidative stress-induced ATG9A ubiquitination at two C-terminal lysine residues (K581 and K838).	Lysine	109-115	TNF receptor associated factor 6	Homo sapiens	30-35
24253041-11	2014	Thus, the conserved Lys-95 charged residue cluster is critical for human RR M2 homodimerization, which is indispensable to constitute an active holoenzyme and function in cells.	Lysine	20-23	ribonucleotide reductase regulatory subunit M2	Homo sapiens	73-78
24371308-6	2014	ChIP-seq analysis uncovered a link between Tcf-1 and RAG2 showing that the two proteins shared binding sites marked by trimethylated histone-3 lysine-4 (H3K4me3) throughout the genome, including near the translocation sites.	Lysine	143-149	transcription factor 7	Homo sapiens	43-48
35432536-12	2022	Meanwhile, ChIP assay showed that the knockdown of KAT6B inhibited the enrichment of histone H3 lysine 23 acetylation (H3K23ac) and RNA polymerase II (RNA pol II) on STAT3 promoter in the cells.	Lysine	96-102	lysine acetyltransferase 6B	Homo sapiens	51-56
35041077-2	2022	In S. cerevisiae, the mono-, di- and tri-methylation of lysine 4 on histone H3 (H3K4) is catalyzed by the protein methyltransferase, Set1.	Lysine	56-62	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	133-137
27711373-3	2016	BACE1 is a catalytic Asp dyad [Asp, Asp-] containing aspartyl protease, while IDE and BILAP are mononuclear [Zn(His, His, Glu)] and binuclear [Zn1(Asp, Glu, Asp)-Zn2(Lys, Glu, Asp, Asp)] core possessing metallopeptidases, respectively.	Lysine	166-169	beta-secretase 1	Bos taurus	0-5
27604544-5	2016	Crystal structures of the anabaenopeptins B, C and F bound to the surrogate protease carboxypeptidase B revealed the binding modes of these large (~850 Da) compounds in detail and explained the observed SAR, i.e. the strong dependence of the potency on a basic (Arg, Lys) exocyclic residue that addressed the S1" binding pocket, and a broad tolerance towards substitutions in the pentacyclic ring that acted as a plug of the active site.	Lysine	267-270	carboxypeptidase B1	Homo sapiens	85-103
27595565-4	2016	HeDNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-binding site.	Lysine	66-73	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	28-33
27595565-4	2016	HeDNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-binding site.	Lysine	66-73	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	105-110
24371308-6	2014	ChIP-seq analysis uncovered a link between Tcf-1 and RAG2 showing that the two proteins shared binding sites marked by trimethylated histone-3 lysine-4 (H3K4me3) throughout the genome, including near the translocation sites.	Lysine	143-149	recombination activating 2	Homo sapiens	53-57
35157847-0	2022	Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.	Lysine	83-89	glutaryl-Coenzyme A dehydrogenase	Mus musculus	19-45
24399296-7	2014	TRAF6 recruited PS1 to the TbetaRI complex and promoted lysine-63-linked polyubiquitination of PS1, which activated PS1.	Lysine	56-62	presenilin 1	Mus musculus	95-98
35157847-5	2022	Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism.	Lysine	39-45	glutaryl-Coenzyme A dehydrogenase	Mus musculus	71-97
35157847-5	2022	Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism.	Lysine	39-45	glutaryl-Coenzyme A dehydrogenase	Mus musculus	99-103
27428926-6	2016	Chromatin immunoprecipitation assays revealed that the levels of trimethylation of lysine 4 on histone H3 (H3K4me3), an active mark for transcription, increased, whereas the levels of H3K9me3 and H3K27me3, which are marks associated with repression of transcription, decreased in the Cyp11a1 proximal promoter after hCG injection.	Lysine	83-89	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	284-291
35157847-5	2022	Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism.	Lysine	39-45	glutaryl-Coenzyme A dehydrogenase	Mus musculus	124-128
24399296-7	2014	TRAF6 recruited PS1 to the TbetaRI complex and promoted lysine-63-linked polyubiquitination of PS1, which activated PS1.	Lysine	56-62	presenilin 1	Mus musculus	95-98
35157847-5	2022	Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism.	Lysine	189-195	glutaryl-Coenzyme A dehydrogenase	Mus musculus	71-97
35157847-5	2022	Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism.	Lysine	189-195	glutaryl-Coenzyme A dehydrogenase	Mus musculus	124-128
24761895-7	2014	RESULTS: For the XPD Lys751Gln polymorphism, the frequency of the Lys allele was higher in cases than in controls (94.5% versus 85.0%).	Lysine	21-24	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	17-20
35157847-6	2022	Our data reveal that glutarylation of GCDH impacts its function, ultimately decreasing lysine oxidation.	Lysine	87-93	glutaryl-Coenzyme A dehydrogenase	Mus musculus	38-42
35157847-9	2022	Together, these data support a feedback loop model within the lysine/tryptophan oxidation pathway in which glutaryl-CoA is produced, in turn inhibiting GCDH function via glutaryl modification of GCDH lysine residues, and can be relieved by SIRT5 deacylation activity.	Lysine	200-206	glutaryl-Coenzyme A dehydrogenase	Mus musculus	152-156
35157847-9	2022	Together, these data support a feedback loop model within the lysine/tryptophan oxidation pathway in which glutaryl-CoA is produced, in turn inhibiting GCDH function via glutaryl modification of GCDH lysine residues, and can be relieved by SIRT5 deacylation activity.	Lysine	200-206	glutaryl-Coenzyme A dehydrogenase	Mus musculus	195-199
35331314-0	2022	Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias.	Lysine	25-31	lysine methyltransferase 2A	Homo sapiens	62-65
27337995-4	2016	Here we report that p49/STRAP overexpression caused the deacetylation of histone H4 on lysine 16 (H4K16) and suppressed the expression of PGC-1alpha as well as mitofusin-1 and mitofusin-2 at both the mRNA and protein levels.	Lysine	87-93	serum response factor binding protein 1	Homo sapiens	20-23
27500495-8	2016	Furthermore, BRPF1 was required for acetylation of histone H3 at lysine 23, a highly abundant but not well-characterized epigenetic mark.	Lysine	65-71	bromodomain and PHD finger containing, 1	Mus musculus	13-18
27550047-1	2016	BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3).	Lysine	273-279	embryonic ectoderm development	Homo sapiens	227-230
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Lysine	36-39	SRY-box transcription factor 2	Homo sapiens	170-174
27369080-3	2016	Post-translational modifications at Lys-156 and K156N, a somatic mutation detected in bladder cancer patients, both impaired the Lys-151-Asp-107 salt bridge and the Oct4/Sox2 interaction.	Lysine	129-132	SRY-box transcription factor 2	Homo sapiens	170-174
27369080-5	2016	Thus, we conclude that Oct4/Lys-156-modulated Oct4/Sox2 interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals.	Lysine	28-31	SRY-box transcription factor 2	Homo sapiens	51-55
24790011-2	2014	In our previous study, we showed that a human galectin-1 (hGal-1) mutant, in which a cysteine residue was introduced at Lys(28), forms a covalently cross-linked complex with the model glycoprotein ligands asialofetuin and laminin by using the photoactivatable sulfhydryl reagent benzophenone-4-maleimide (BPM).	Lysine	120-123	galectin 1	Homo sapiens	46-56
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	DEAD/H box helicase 58	Mus musculus	109-114
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	DEAD/H box helicase 58	Mus musculus	259-264
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	DEAD/H box helicase 58	Mus musculus	259-264
27506794-5	2016	The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.	Lysine	198-201	DEAD/H box helicase 58	Mus musculus	259-264
35320725-2	2022	Here, we show that human SPT16 is ubiquitylated at lysine-674 (K674) by the DCAF14-CRL4 ubiquitin ligase.	Lysine	51-57	SPT16 homolog, facilitates chromatin remodeling subunit	Homo sapiens	25-30
35320725-2	2022	Here, we show that human SPT16 is ubiquitylated at lysine-674 (K674) by the DCAF14-CRL4 ubiquitin ligase.	Lysine	51-57	interleukin 17 receptor B	Homo sapiens	83-87
24790011-2	2014	In our previous study, we showed that a human galectin-1 (hGal-1) mutant, in which a cysteine residue was introduced at Lys(28), forms a covalently cross-linked complex with the model glycoprotein ligands asialofetuin and laminin by using the photoactivatable sulfhydryl reagent benzophenone-4-maleimide (BPM).	Lysine	120-123	galectin 1	Homo sapiens	58-64
35411237-3	2022	Lysine-specific histone methyltransferase 2D (KMT2D) has a two-fold higher mutation frequency in metastatic cSCCs relative to primary non-metastatic associated cSCCs.	Lysine	0-6	lysine methyltransferase 2D	Homo sapiens	46-51
27540854-4	2016	They elegantly demonstrate that DNA methylation and transcriptional activation at the HDAC9 promoter by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events during host defense.	Lysine	123-129	histone deacetylase 9	Homo sapiens	155-160
24268540-1	2014	L,L-Diaminopimelate aminotransferase (DapL) is an enzyme required for the biosynthesis of meso-diaminopimelate (m-DAP) and L-lysine (Lys) in some bacteria and photosynthetic organisms.	Lysine	123-131	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	0-36
27487210-7	2016	Our data reveal that CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases, suggesting that the mTORC1 pathway exploited an ancient, amino-acid-dependent allosteric mechanism to acquire arginine sensitivity.	Lysine	77-83	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	21-28
27507651-1	2016	Fasci et al proposed that a SENP1-mediated switch from SUMO2 to SUMO1 conjugation on Lys(65) in promyelocytic leukemia protein (PML) is required for arsenic-induced PML degradation, the basis for the antileukemic activity of arsenic.	Lysine	85-88	small ubiquitin like modifier 2	Homo sapiens	55-60
35592609-6	2022	However, 53BP1-FFR only binds nucleosomes modified with both H2AK15Ub and dimethylation of lysine 20 on histone H4 (H4K20me2); thus, 53BP1-FFR does not recognize H2AK13Ub-nucleosomes or nucleosomes that contain H2AK15Ub but lack methylation of H4K20 (H4K20me0).	Lysine	91-97	H4 clustered histone 2	Homo sapiens	104-114
35246238-2	2022	SETD8 is so far the only known lysyl methyltransferase in mammalian cells to produce mono-methylation of histone H4 at lysine 20 (H4K20me1), a prerequisite for di- and tri-methylation.	Lysine	119-125	H4 clustered histone 6	Homo sapiens	105-115
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	36-39	protein PML	Mandrillus leucophaeus	47-50
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	36-39	protein PML	Mandrillus leucophaeus	149-152
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	92-95	protein PML	Mandrillus leucophaeus	47-50
27507652-2	2016	We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML.	Lysine	92-95	protein PML	Mandrillus leucophaeus	149-152
24268540-1	2014	L,L-Diaminopimelate aminotransferase (DapL) is an enzyme required for the biosynthesis of meso-diaminopimelate (m-DAP) and L-lysine (Lys) in some bacteria and photosynthetic organisms.	Lysine	123-131	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	38-42
24268540-1	2014	L,L-Diaminopimelate aminotransferase (DapL) is an enzyme required for the biosynthesis of meso-diaminopimelate (m-DAP) and L-lysine (Lys) in some bacteria and photosynthetic organisms.	Lysine	133-136	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	0-36
24268540-1	2014	L,L-Diaminopimelate aminotransferase (DapL) is an enzyme required for the biosynthesis of meso-diaminopimelate (m-DAP) and L-lysine (Lys) in some bacteria and photosynthetic organisms.	Lysine	133-136	LL-diaminopimelate aminotransferase	Arabidopsis thaliana	38-42
24901011-6	2014	To fulfill these multiple roles, T-bet undergoes several posttranslational protein modifications, such as phosphorylation at tyrosine, serine, and threonine residues, and ubiquitination at lysine residues, which affect lineage commitment during Th cell differentiation.	Lysine	189-195	T-box transcription factor 21	Homo sapiens	33-38
27239721-1	2016	Histone deacetylase (EC 3.5.1.98 - HDAC) is an amidohydrolase involved in deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital role in the epigenetic regulation of gene expression.	Lysine	100-106	histone deacetylase 9	Homo sapiens	35-39
27256846-4	2016	We also found reduced global acetylation of histone H3 lysine 14 (H3K14) in BRPF2-depleted ESCs, irrespective of differentiation status.	Lysine	55-61	bromodomain and PHD finger containing, 1	Mus musculus	76-81
27250824-9	2016	Molecular analysis of the beta-globin gene showed heterozygosity for an AAG &gt; ACG substitution at codon 144, resulting in a Lys Thr amino acid replacement.	Lysine	127-130	N-methylpurine DNA glycosylase	Homo sapiens	72-75
34987057-7	2022	Loss of ARID1A in lung adenocarcinoma also resulted in loss of histone deacetylase 1 (HDAC1) recruitment, increasing acetylation of histone 4 lysine at the promoters of Pgam1, Pkm, and Pgk1 and subsequently enhancing BRD4-driven transcription of these genes.	Lysine	142-148	AT rich interactive domain 1A (SWI-like)	Mus musculus	8-14
34987057-7	2022	Loss of ARID1A in lung adenocarcinoma also resulted in loss of histone deacetylase 1 (HDAC1) recruitment, increasing acetylation of histone 4 lysine at the promoters of Pgam1, Pkm, and Pgk1 and subsequently enhancing BRD4-driven transcription of these genes.	Lysine	142-148	phosphoglycerate mutase 1	Homo sapiens	169-174
34987057-7	2022	Loss of ARID1A in lung adenocarcinoma also resulted in loss of histone deacetylase 1 (HDAC1) recruitment, increasing acetylation of histone 4 lysine at the promoters of Pgam1, Pkm, and Pgk1 and subsequently enhancing BRD4-driven transcription of these genes.	Lysine	142-148	pyruvate kinase M1/2	Homo sapiens	176-179
24117969-5	2014	Purified ADAM10 cleaved NCAM at a sequence within the E-F loop of the second fibronectin type III domain (Leu(671) -Lys(672) /Ser(673) -Leu(674) ) identified by mass spectrometry.	Lysine	116-119	neural cell adhesion molecule 1	Homo sapiens	24-28
35124181-10	2022	Furthermore, ZKSCAN3 was a novel substrate of SIRT1 which was deacetylated at lysine 148 residues by SIRT1.	Lysine	78-84	sirtuin 1	Mus musculus	46-51
35124181-10	2022	Furthermore, ZKSCAN3 was a novel substrate of SIRT1 which was deacetylated at lysine 148 residues by SIRT1.	Lysine	78-84	sirtuin 1	Mus musculus	101-106
35033534-1	2022	The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20-Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity.	Lysine	11-17	PHD finger protein 20 like 1	Homo sapiens	84-96
27146988-9	2016	Kv1.3/Nedd4-2 were reciprocally coimmunoprecipated, whereby mutation of the COOH-terminal, SH3-recognition (493-498), or ubiquitination sites on Kv1.3 (lysines 467, 476, 498) retained coimmunoprecipitation, while the latter prevented the reduction in channel density.	Lysine	152-159	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	6-13
23929215-1	2014	Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL) fusion protein-driven leukemias.	Lysine	79-86	lysine methyltransferase 2A	Homo sapiens	206-209
27472901-2	2016	Here, using large-scale RNA interference (RNAi) screening, we find that KDM3A, a histone H3 lysine 9 (H3K9) mono- and di-demethylase, plays a pivotal role in anoikis induction.	Lysine	92-98	lysine demethylase 3A	Homo sapiens	72-77
35033534-1	2022	The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20-Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity.	Lysine	11-17	PHD finger protein 20 like 1	Homo sapiens	98-105
35301489-4	2022	Specifically, the SAGA complex acetylates its Ada3 subunit at three sites (lysines 8, 14 and 182) that are dynamically deacetylated by Rpd3.	Lysine	75-82	histone acetyltransferase NGG1	Saccharomyces cerevisiae S288C	46-50
35301489-5	2022	The acetylated Ada3 lysine residues are bound by bromodomains within SAGA subunits Gcn5 and Spt7 that synergistically facilitate formation of SAGA homo-dimers.	Lysine	20-26	histone acetyltransferase NGG1	Saccharomyces cerevisiae S288C	15-19
27288411-3	2016	Specifically, the BRCA1-A complex not only recognizes Lys(63)-linked ubiquitin (K63-Ub) adducts at the damaged chromatin but is endowed with K63-Ub deubiquitylase (DUB) activity.	Lysine	54-57	BRCA1 DNA repair associated	Homo sapiens	18-23
25217584-2	2014	We have studied the effect of activation of the retinoic A receptor, at the RARE-promoter chromatin of CASP9 and CYP26A1 genes, 15 and 45 min following RA exposure, and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 and by the JMJ-domain containing demethylase, D2A.	Lysine	194-201	caspase 9	Homo sapiens	103-108
27131890-4	2016	Here we report the development of a novel kinetic method for measuring isopeptidase activity of human TG2 by monitoring decrease in the fluorescence polarization of a protein substrate previously formed by crosslinking fluorescently labeled glutamine donor FLpepT26 to S100A4 at a specific lysine residue.	Lysine	290-296	S100 calcium binding protein A4	Homo sapiens	269-275
35441145-0	2022	Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration.	Lysine	73-79	sirtuin 2	Homo sapiens	58-63
24038750-3	2014	We further discovered that the silencing of Oct4 significantly reduces the expression of Sirt1, a deacetylase known to inhibit p53 activity and the differentiation of ESCs, leading to increased acetylation of p53 at lysine 120 and 164.	Lysine	216-222	POU class 5 homeobox 1	Homo sapiens	44-48
35336871-3	2022	The most influential E1B-55K PTMs are phosphorylation at highly conserved serine and threonine residues at the C-terminus, and SUMO conjugation to lysines 104 (K104) and 101 (K101) situated in the N-terminal region of the protein, which have been shown to regulate each other.	Lysine	147-154	small nucleolar RNA, H/ACA box 73A	Homo sapiens	21-24
35134360-1	2022	For 36 years, the acetylation of lysine 40 in alpha-tubulin has provided the paradigm for how post-translational acetylation stabilises microtubules.	Lysine	33-39	tubulin alpha 1b	Homo sapiens	46-59
35134360-2	2022	A new study demonstrates that acetylation of lysine 394 in alpha-tubulin also mediates microtubule stabilisation in neurons.	Lysine	45-51	tubulin alpha 1b	Homo sapiens	59-72
27226597-4	2016	We used the genetic code expansion concept to produce natively folded, site-specific, and lysine-acetylated Sirt1-3 substrate proteins, namely Ras-related nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation reaction.	Lysine	90-96	sirtuin 1	Homo sapiens	108-113
27226597-7	2016	Using a structural and functional approach, we describe the ability of Sirt1-3 to deacetylate two adjacent acetylated lysine residues.	Lysine	118-124	sirtuin 1	Homo sapiens	71-76
27023356-1	2016	OBJECTIVES: To establish a method for microbial transglutaminase (mTG)-mediated PEGylation of proteins at the level of lysine (Lys) residues.	Lysine	119-125	protease, serine 3	Mus musculus	66-69
27023356-1	2016	OBJECTIVES: To establish a method for microbial transglutaminase (mTG)-mediated PEGylation of proteins at the level of lysine (Lys) residues.	Lysine	127-130	protease, serine 3	Mus musculus	66-69
27023356-5	2016	CONCLUSIONS: This is the first study regarding the PEGylation of protein at the level of Lys residues catalyzed by mTG.	Lysine	89-92	protease, serine 3	Mus musculus	115-118
24257756-7	2013	Interestingly, the phosphorylation of Thr(486), located in close proximity to SUMOylation site Lys(499) of c-Myb, is detected preferentially in nonSUMOylated protein and has a negative effect on stress-induced SUMOylation of c-Myb.	Lysine	95-98	MYB proto-oncogene, transcription factor	Homo sapiens	107-112
27212567-0	2016	A Prospective Case Study of the Safety and Efficacy of Lysine-Restricted Diet and Arginine Supplementation Therapy in a Patient With Pyridoxine-Dependent Epilepsy Caused by Mutations in ALDH7A1.	Lysine	55-61	aldehyde dehydrogenase 7 family member A1	Homo sapiens	186-193
24257756-7	2013	Interestingly, the phosphorylation of Thr(486), located in close proximity to SUMOylation site Lys(499) of c-Myb, is detected preferentially in nonSUMOylated protein and has a negative effect on stress-induced SUMOylation of c-Myb.	Lysine	95-98	MYB proto-oncogene, transcription factor	Homo sapiens	225-230
27212567-1	2016	BACKGROUND: Pyridoxine-dependent epilepsy (PDE) is caused by mutations in ALDH7A1 (PDE-ALDH7A1), which encodes alpha-aminoadipic semialdehyde dehydrogenase in the lysine catabolic pathway, resulting in accumulation of alpha-aminoadipic-acid-semialdehyde.	Lysine	163-169	aldehyde dehydrogenase 7 family member A1	Homo sapiens	74-81
27212567-1	2016	BACKGROUND: Pyridoxine-dependent epilepsy (PDE) is caused by mutations in ALDH7A1 (PDE-ALDH7A1), which encodes alpha-aminoadipic semialdehyde dehydrogenase in the lysine catabolic pathway, resulting in accumulation of alpha-aminoadipic-acid-semialdehyde.	Lysine	163-169	aldehyde dehydrogenase 7 family member A1	Homo sapiens	83-94
24194518-2	2013	Cbx7 recognizes methylated lysine residues on the histone H3 tail and contributes to gene silencing in the context of the Polycomb repressive complex 1 (PRC1).	Lysine	27-33	chromobox 7	Mus musculus	0-4
27212567-1	2016	BACKGROUND: Pyridoxine-dependent epilepsy (PDE) is caused by mutations in ALDH7A1 (PDE-ALDH7A1), which encodes alpha-aminoadipic semialdehyde dehydrogenase in the lysine catabolic pathway, resulting in accumulation of alpha-aminoadipic-acid-semialdehyde.	Lysine	163-169	aldehyde dehydrogenase 7 family member A1	Homo sapiens	111-155
27212567-2	2016	PATIENT DESCRIPTION AND RESULTS: We present a three-year treatment outcome of a child with PDE-ALDH7A1 on pyridoxine (started at age three weeks of age), lysine-restricted diet (started at age seven months), and arginine supplementation therapy (started at age 26 months).	Lysine	154-160	aldehyde dehydrogenase 7 family member A1	Homo sapiens	91-102
27056598-1	2016	Lysine methyltransferases G9a and GLP (G9a-like protein) are highly homologous and form functional heterodimeric complexes that establish mono- and dimethylation on histone H3 lysine 9 (H3K9me1, H3K9me2) in euchromatin.	Lysine	176-182	euchromatic histone lysine methyltransferase 2	Homo sapiens	26-29
35115608-3	2022	Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center on blocking the WIN site of WDR5, an arginine binding cavity that engages MLL/SET enzymes that deposit histone H3 lysine 4 methylation (H3K4me).	Lysine	207-213	lysine methyltransferase 2A	Homo sapiens	167-170
24162848-7	2013	Xist binding is linearly proportional to PRC2 density and H3 lysine 27 trimethylation (H3K27me3), indicating co-migration of Xist and PRC2.	Lysine	61-67	X inactive specific transcript	Homo sapiens	0-4
35163387-3	2022	CyPA was recently found to undergo acetylation at K82 and K125, two lysine residues conserved in most species, and these modifications are required for secretion of CyPA in response to cell activation in vascular smooth muscle cells.	Lysine	68-74	peptidylprolyl isomerase A	Homo sapiens	0-4
34643234-7	2022	The case of heterochromatin protein 1alpha complexed with lysine 9-methylated histone H3, which is critical for genomic stability and cell differentiation, was used to demonstrate its applicability.	Lysine	58-64	chromobox 5	Homo sapiens	12-42
27135738-0	2016	An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.	Lysine	85-91	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	13-17
27462461-6	2016	Moreover, the acetylation of Cdc25A at lysine 150, which was acetylated by p300/CBP and deacetylated by HDAC3, prevented the ubiquitin-mediated degradation of Cdc25A by the proteasome.	Lysine	39-45	cell division cycle 25A	Homo sapiens	29-35
24162848-7	2013	Xist binding is linearly proportional to PRC2 density and H3 lysine 27 trimethylation (H3K27me3), indicating co-migration of Xist and PRC2.	Lysine	61-67	X inactive specific transcript	Homo sapiens	125-129
27462461-6	2016	Moreover, the acetylation of Cdc25A at lysine 150, which was acetylated by p300/CBP and deacetylated by HDAC3, prevented the ubiquitin-mediated degradation of Cdc25A by the proteasome.	Lysine	39-45	cell division cycle 25A	Homo sapiens	159-165
35111761-3	2021	The only recognized molecular function of DOT1L is its methylation of histone H3 lysine 79 (H3K79).	Lysine	81-87	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	42-47
27210293-2	2016	Previous studies have identified Cxxc1 as a regulator of both cytosine methylation and histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	97-103	CXXC finger 1 (PHD domain)	Mus musculus	33-38
24349215-2	2013	To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase, Mcm2-7 (also comprised of AAA+ proteins), we mutated the conserved lysine residue in the putative PS1 hairpin motif in each of the Saccharomyces cerevisiae Mcm2-7 subunits to alanine.	Lysine	173-179	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	106-112
26893353-9	2016	We finally conducted an exploratory screen for inhibitors of the interaction between Spindlin1 and H3K4me3 and identified A366 as the first nanomolar small-molecule ligand of a Tudor domain containing methyl lysine reader.	Lysine	208-214	spindlin 1	Homo sapiens	85-94
24349215-2	2013	To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase, Mcm2-7 (also comprised of AAA+ proteins), we mutated the conserved lysine residue in the putative PS1 hairpin motif in each of the Saccharomyces cerevisiae Mcm2-7 subunits to alanine.	Lysine	173-179	MCM DNA helicase complex subunit MCM2	Saccharomyces cerevisiae S288C	262-268
24113524-8	2013	Acetylation of p53 at the SIRT1-specific lysine 379 site was markedly decreased.	Lysine	41-47	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	15-18
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	72-75	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	33-39
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	72-75	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	72-75	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	146-149	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	33-39
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	146-149	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Lysine	146-149	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
24196706-5	2013	Loss of EHMT1 in brown adipocytes causes a severe loss of brown fat characteristics and induces muscle differentiation in vivo through demethylation of histone 3 lysine 9 (H3K9me2 and 3) of the muscle-selective gene promoters.	Lysine	162-168	euchromatic histone lysine methyltransferase 1	Homo sapiens	8-13
24125069-5	2013	Here, we report that histone acetyltransferase Hbo1 promotes destabilization of estrogen receptor alpha (ERalpha) in breast cancers through lysine 48-linked ubiquitination.	Lysine	140-146	lysine acetyltransferase 7	Homo sapiens	47-51
27084451-5	2016	In addition, we found that the lysine residues of Herp (which are ubiquitinated by E3 ubiquitin ligase) are not sufficient for regulation of Herp degradation.	Lysine	31-37	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	Mus musculus	50-54
27009953-7	2016	HCF1 depletion led to a loss of histone H3K4me3 (trimethylation of histone H3 at lysine 4) and H3 acetylation at Cp in type III latency and Qp in type I latency, as well as an increase in heterochromatic H3K9me3 at these sites.	Lysine	81-87	host cell factor C1	Homo sapiens	0-4
24135048-4	2013	Chromatin immunoprecipitation assay revealed that levels of lysine 9-acetylated histone H3 (H3K9Ac) and lysine 4-trimethylated H3 (H3K4me(3)) in the promoter regions of the CCL2 and CCL3 genes were increased in the injured SCN after PSL, indicating the enhancement of gene expression.	Lysine	60-66	chemokine (C-C motif) ligand 3	Mus musculus	182-186
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	Lysine	106-112	sirtuin 7	Homo sapiens	59-64
26704979-3	2016	Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm.	Lysine	106-112	sirtuin 7	Homo sapiens	170-175
23619164-6	2013	The in-silico model indicated that the 55-66 amino-acid segment of IMPase anchors calbindin via Lys59 and Lys61 with a glutamate in between (Lys-Glu-Lys motif) and that the motif interacts with residues Asp24 and Asp26 of calbindin.	Lysine	96-99	calbindin 1	Homo sapiens	82-91
26968571-0	2016	Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach.	Lysine	32-38	LOC102641229	Mus musculus	77-87
23619164-6	2013	The in-silico model indicated that the 55-66 amino-acid segment of IMPase anchors calbindin via Lys59 and Lys61 with a glutamate in between (Lys-Glu-Lys motif) and that the motif interacts with residues Asp24 and Asp26 of calbindin.	Lysine	106-109	calbindin 1	Homo sapiens	82-91
26968571-1	2016	We developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the site-specific quantification of lysine acetylation in the N-terminal region of histone H4 by combining chemical derivatization at the protein and peptide levels with digestion using chymotrypsin and trypsin.	Lysine	129-135	LOC102641229	Mus musculus	176-186
23619164-8	2013	Calbindin"s effect was significantly reduced by a linear peptide with the sequence of amino acids 58-63 of IMPase (peptide 1) and by six amino-acid linear peptides including at least part of the Lys-Glu-Lys motif.	Lysine	195-198	calbindin 1	Homo sapiens	0-9
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	107-110	lysine demethylase 1B	Homo sapiens	175-179
26933034-5	2016	We demonstrate that the CW domains in ZCWPW2 and MORC3/4 selectively recognize histone H3 trimethylated at Lys-4, similar to ZCWPW1 reported previously, while the MORC1/2 and LSD2 lack histone H3 Lys-4 binding ability.	Lysine	196-199	lysine demethylase 1B	Homo sapiens	175-179
23619164-8	2013	Calbindin"s effect was significantly reduced by a linear peptide with the sequence of amino acids 58-63 of IMPase (peptide 1) and by six amino-acid linear peptides including at least part of the Lys-Glu-Lys motif.	Lysine	203-206	calbindin 1	Homo sapiens	0-9
24126058-4	2013	Here we show that DBC1 is modified by acetylation on two N-terminal lysine residues (K112 and K215).	Lysine	68-74	cell cycle and apoptosis regulator 2	Homo sapiens	18-22
27098497-4	2016	Here we report that in Schizosaccharomyces pombe a conserved DDB1-CUL4-associated factor (DCAF), Wdr70, is recruited to DSBs as part of the Cullin4-DDB1 ubiquitin ligase (CRL4(Wdr70)) and stimulates distal H2B lysine 119 mono-ubiquitination (uH2B).	Lysine	210-216	WD repeat domain 70	Homo sapiens	97-102
27098497-4	2016	Here we report that in Schizosaccharomyces pombe a conserved DDB1-CUL4-associated factor (DCAF), Wdr70, is recruited to DSBs as part of the Cullin4-DDB1 ubiquitin ligase (CRL4(Wdr70)) and stimulates distal H2B lysine 119 mono-ubiquitination (uH2B).	Lysine	210-216	WD repeat domain 70	Homo sapiens	176-181
26930370-8	2016	There was a reduction in the level of lysine in serum of FSHD, LGMD-2B and DM-1 patients as compared to normal subjects.	Lysine	38-44	FSHMD1A	Homo sapiens	57-61
26930370-8	2016	There was a reduction in the level of lysine in serum of FSHD, LGMD-2B and DM-1 patients as compared to normal subjects.	Lysine	38-44	DM1 protein kinase	Homo sapiens	75-79
24145029-11	2013	Lys-159, the kinase-active site of NleH1, was necessary for its interaction with CRKL.	Lysine	0-3	CRK like proto-oncogene, adaptor protein	Homo sapiens	81-85
27058665-2	2016	Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, including almost all super-enhancers.	Lysine	107-113	zinc finger MYND-type containing 8	Homo sapiens	84-89
24121500-0	2013	Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.	Lysine	97-104	sirtuin 3	Mus musculus	0-9
26996342-2	2016	Recently, however, our group discovered that the severe methylation of lysine 9 in Histone H3 in a human somatic cell genome was a major SCNT reprogramming barrier, and the overexpression of KDM4A, a H3K9me3 demethylase, significantly improved the blastocyst formation of SCNT embryos.	Lysine	71-77	lysine demethylase 4A	Homo sapiens	191-196
24121500-0	2013	Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.	Lysine	97-104	sirtuin 3	Mus musculus	11-16
24121500-0	2013	Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.	Lysine	97-104	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	36-69
24121500-2	2013	We previously demonstrated increased LCAD lysine acetylation in SIRT3 knockout mice concomitant with reduced LCAD activity and reduced fatty acid oxidation.	Lysine	42-48	acyl-Coenzyme A dehydrogenase, long-chain	Mus musculus	37-41
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	263-269	lysine acetyltransferase 5	Homo sapiens	178-183
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	263-269	lysine acetyltransferase 5	Homo sapiens	185-189
24121500-2	2013	We previously demonstrated increased LCAD lysine acetylation in SIRT3 knockout mice concomitant with reduced LCAD activity and reduced fatty acid oxidation.	Lysine	42-48	sirtuin 3	Mus musculus	64-69
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	309-315	lysine acetyltransferase 5	Homo sapiens	178-183
24121500-6	2013	Residues Lys-318 and Lys-322 were identified as SIRT3-targeted lysines.	Lysine	9-12	sirtuin 3	Mus musculus	48-53
26822153-3	2016	Here, we report that Dicer- and Drosha-dependent diRNAs function as guiding molecules to promote the recruitment of the methyltransferase MMSET (WHSC1) and the acetyltransferase Tip60 (KAT5) to the DSB, where local levels of histone H4 di- and tri-methylation at lysine 20 (H4K20me2, 3) and H4 acetylation at lysine 16 (H4K16Ac) were enhanced.	Lysine	309-315	lysine acetyltransferase 5	Homo sapiens	185-189
24121500-6	2013	Residues Lys-318 and Lys-322 were identified as SIRT3-targeted lysines.	Lysine	21-24	sirtuin 3	Mus musculus	48-53
24121500-6	2013	Residues Lys-318 and Lys-322 were identified as SIRT3-targeted lysines.	Lysine	63-70	sirtuin 3	Mus musculus	48-53
24121500-10	2013	Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation.	Lysine	91-98	sirtuin 3	Mus musculus	181-186
26997278-2	2016	G9a, the enzyme responsible for histone H3 lysine 9 dimethylation in mammalian euchromatin, exists as two isoforms with differential inclusion of exon 10 (E10) through alternative splicing.	Lysine	43-49	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
24121500-10	2013	Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation.	Lysine	126-129	sirtuin 3	Mus musculus	181-186
24121500-10	2013	Medium-chain acyl-CoA dehydrogenase and acyl-CoA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation.	Lysine	134-137	sirtuin 3	Mus musculus	181-186
24088021-4	2013	We identified eight cathepsin K specific arginine/lysine residues that form three positively charged clusters at the bottom part of the protease opposing the active site.	Lysine	50-56	cathepsin K	Homo sapiens	20-31
27005833-2	2016	Here we demonstrate that acetylation of C/EBPalpha at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPalpha DNA-binding ability and modulates C/EBPalpha transcriptional activity.	Lysine	54-60	lysine acetyltransferase 2A	Homo sapiens	151-155
26934656-5	2016	Here, we demonstrated that P300 binds to and increases histone H3 lysine 27 acetylation (H3K27Ac) in the FASN gene promoter.	Lysine	66-72	fatty acid synthase	Homo sapiens	105-109
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Lysine	66-72	SUN domain containing ossification factor	Homo sapiens	89-92
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Lysine	159-166	SUN domain containing ossification factor	Homo sapiens	89-92
26907567-3	2016	Here, we reported that SIRT7 can be activated by DNA to hydrolyze the acetyl group from lysine residues in vitro on histone peptides and histones in the chromatin context.	Lysine	88-94	sirtuin 7	Homo sapiens	23-28
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Lysine	168-171	SUN domain containing ossification factor	Homo sapiens	89-92
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Lysine	176-179	SUN domain containing ossification factor	Homo sapiens	89-92
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Lysine	176-179	SUN domain containing ossification factor	Homo sapiens	89-92
26148240-6	2016	In agreement, co-immunoprecipitation experiments demonstrated that FOXM1 expression is associated with OTUB1 binding but inversely correlates with conjugation to the protein degradation-associated Lys-48-linked ubiquitin-chains.	Lysine	197-200	forkhead box M1	Homo sapiens	67-72
24617002-3	2013	METHOD: A case-control study was conducted involving 233 LSCC patients and 102 healthy controls to investigate the association between polymorphisms of XPD(751 Lys/Gln), XPC (PAT) and LSCC.	Lysine	160-163	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	152-155
26934322-7	2016	The downregulation of ZEB1 in fBMFs by resveratrol was mediated by epigenetic mechanisms, such as the upregulated expression of miR-200c and the enhancer of zeste homolog 2 (EZH2), as well as the trimethylated lysine 27 of histone H3 (H3K27me3).	Lysine	210-216	zinc finger E-box binding homeobox 1	Homo sapiens	22-26
26717101-1	2016	The tumor suppressor, cylindromatosis (CYLD), is a negative regulator of NF-kappaB signaling by removing lysine 63-linked ubiquitin chains from multiple NF-kappaB signaling components, including TRAF2, TRAF6, and NEMO.	Lysine	105-111	CYLD lysine 63 deubiquitinase	Homo sapiens	22-37
24088713-3	2013	SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1.	Lysine	67-73	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
26717101-1	2016	The tumor suppressor, cylindromatosis (CYLD), is a negative regulator of NF-kappaB signaling by removing lysine 63-linked ubiquitin chains from multiple NF-kappaB signaling components, including TRAF2, TRAF6, and NEMO.	Lysine	105-111	CYLD lysine 63 deubiquitinase	Homo sapiens	39-43
26717101-1	2016	The tumor suppressor, cylindromatosis (CYLD), is a negative regulator of NF-kappaB signaling by removing lysine 63-linked ubiquitin chains from multiple NF-kappaB signaling components, including TRAF2, TRAF6, and NEMO.	Lysine	105-111	TNF receptor associated factor 2	Homo sapiens	195-200
23921388-3	2013	In this study, we identified the methyltransferase METTL21A as the enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins.	Lysine	120-126	methyltransferase 21A, HSPA lysine	Homo sapiens	51-59
26880641-12	2016	LSD1 specifically removes methyl groups from di- and mono-methylated lysines at position 4 of histone 3.	Lysine	69-76	lysine demethylase 1A	Homo sapiens	0-4
26781306-8	2016	One novel non-synonymous mutation (Asn to Lys) in CYP2C19 was identified, and this mutation was predicted to be intolerant and benign by SIFT and PolyPhen-2, respectively.	Lysine	42-45	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	50-57
24143054-5	2013	We show that the lysine residues important for function of CD271 death domain are predicted to be and glycated.	Lysine	17-23	nerve growth factor receptor	Homo sapiens	59-64
23947381-8	2013	MEASUREMENTS AND MAIN RESULTS: Poly-L-lysine compacts CF sputum DNA, generating a liquid phase that improves ciliary beating frequency at the lung epithelial surface, and allows the control of neutrophil elastase and cathepsin G by their natural inhibitors.	Lysine	31-44	cathepsin G	Homo sapiens	217-228
26649560-9	2016	In addition, a protein phosphatase 2A regulator (TIP41) was validated to harbor a functional PTS1 (Ser-Lys-Val&gt;), but the full-length protein targeted cytosol and nucleus.	Lysine	103-106	tonoplast intrinsic protein 4;1	Arabidopsis thaliana	49-54
27326334-1	2016	The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus.	Lysine	273-279	CDKN2B antisense RNA 1	Homo sapiens	170-175
26719330-2	2016	RAP80 is a component of the BRCA1 A complex, and plays a key role in the recruitment process through the binding of Lys(63)-linked poly-Ub chains by tandem Ub interacting motifs (UIM).	Lysine	116-119	ubiquitin interaction motif containing 1	Homo sapiens	0-5
26719330-2	2016	RAP80 is a component of the BRCA1 A complex, and plays a key role in the recruitment process through the binding of Lys(63)-linked poly-Ub chains by tandem Ub interacting motifs (UIM).	Lysine	116-119	BRCA1 DNA repair associated	Homo sapiens	28-33
24039768-3	2013	A fraction of AUP1 is monoubiquitinated at various lysine residues.	Lysine	51-57	AUP1 lipid droplet regulating VLDL assembly factor	Homo sapiens	14-18
26746851-4	2016	HDAC6 transiently bound to RIG-I and removed the lysine 909 acetylation in the presence of viral RNAs, promoting RIG-I sensing of viral RNAs.	Lysine	49-55	DEAD/H box helicase 58	Mus musculus	113-118
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	110-113	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
26747897-2	2016	Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells in vitro and in vivo.	Lysine	36-42	lysine demethylase 5D	Homo sapiens	64-71
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
23673479-10	2013	We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).	Lysine	114-117	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	106-109
26626994-10	2016	Without its C terminus, alpha2AP can no longer bind to the lysine binding sites of plasmin(ogen) and is only a kinetically slow plasmin inhibitor.	Lysine	59-65	serpin family F member 2	Homo sapiens	24-32
23973222-2	2013	Here, we demonstrate that the expression of the transcription factor Foxp3 can be regulated through the polyubiquitination of multiple lysine residues, resulting in proteasome-mediated degradation.	Lysine	135-141	forkhead box P3	Mus musculus	69-74
26862182-9	2016	Polyphosphorylation occurs within a conserved N-terminal polyacidic serine (S) and lysine (K) rich (PASK) cluster.	Lysine	83-89	PAS domain containing serine/threonine kinase	Homo sapiens	100-104
23962979-6	2013	We found that Syk was present in both TRAF6- and TRAF3-containing signaling complexes; however, the LPS-dependent, lysine 63-linked ubiquitination of TRAF6 and TRAF3 was oppositely regulated by Syk.	Lysine	115-121	TNF receptor associated factor 6	Homo sapiens	150-155
26731476-6	2016	ETV1 facilitated the recruitment of JMJD2A to the YAP1 promoter, leading to changes in histone lysine methylation in a human prostate cancer cell line.	Lysine	95-101	lysine demethylase 4A	Homo sapiens	36-42
26307668-2	2016	The Enhancer of Zeste homology 2 (EZH2), which methylates histone H3 on lysine 27 (H3K27me3), controls MSC cell lineage commitment.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	4-32
26307668-2	2016	The Enhancer of Zeste homology 2 (EZH2), which methylates histone H3 on lysine 27 (H3K27me3), controls MSC cell lineage commitment.	Lysine	72-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	34-38
23933260-1	2013	Chromatin posttranslational modifications (PTMs), including monoubiquitylation of histone H2B on lysine 120 (H2Bub1), play a major role in regulating genome functions.	Lysine	97-103	H2B clustered histone 21	Homo sapiens	90-93
23898190-4	2013	SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replication stress in a manner that is partially dependent on ataxia telangiectasia and Rad3 related (ATR) but not cyclin T or K, thereby stimulating CDK9 kinase activity and promoting recovery from replication arrest.	Lysine	46-52	sirtuin 2	Mus musculus	0-5
26352615-5	2016	SlGLK2 is degraded by the ubiquitin-proteasome system, which is mainly determined by two lysine residues (K11 and K253).	Lysine	89-95	transcription factor GLK2	Solanum lycopersicum	0-6
23928698-4	2013	A triple Lys mutant of Aurora B (K102/103/(207R)) exhibited optimal resistance to SCF(FBXL2)-directed polyubiquitination, and overexpression of this variant resulted in a significant delay in anaphase onset, resulting in apoptosis.	Lysine	9-12	kit ligand	Mus musculus	82-85
26774480-4	2016	Examination of the serine-glycine synthesis pathway reveals that KDM4C epigenetically activates the pathway genes under steady-state and serine deprivation conditions by removing the repressive histone modification H3 lysine 9 (H3K9) trimethylation.	Lysine	218-224	lysine demethylase 4C	Homo sapiens	65-70
23786712-2	2013	MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of D-Ala-D-Ala to the nucleotide precursor UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP (or L-Lys).	Lysine	170-175	tripartite motif containing 54	Homo sapiens	0-4
26812616-6	2016	The PBRM1 mutations were located in a bromodomain (80Asn&gt;Ser) and an HMG-box domain (1,377Glu&gt;Lys).	Lysine	100-103	polybromo 1	Homo sapiens	4-9
26748699-2	2016	We show that astrin, a microtubule-organizing protein, co-purifies with Mid1 and Mid2, has an overlapping localization with Mid1 and Mid2 at intercellular bridge microtubules, is ubiquitinated by Mid2 on lysine 409, and is degraded during cytokinesis.	Lysine	204-210	sperm associated antigen 5	Homo sapiens	13-19
23720746-1	2013	alpha-Tubulin acetylation at Lys-40, located on the luminal side of microtubules, has been widely studied and used as a marker for stable microtubules in the cilia and other subcellular structures, but the functional consequences remain perplexing.	Lysine	29-32	tubulin alpha 1b	Homo sapiens	0-13
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	63-66	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	101-104
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	63-66	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	151-154
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	63-66	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	159-162
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	151-154
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	159-162
23727017-5	2013	MITOL mediated lysine-63-linked polyubiquitin chain addition to Mfn2, but not its proteasomal degradation.	Lysine	15-21	membrane associated ring-CH-type finger 5	Homo sapiens	0-5
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	151-154
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Lysine	89-92	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	159-162
23723094-1	2013	The JIL-1 kinase localizes to Drosophila polytene chromosome interbands and phosphorylates histone H3 at interphase, counteracting histone H3 lysine 9 dimethylation and gene silencing.	Lysine	142-148	JIL-1 kinase	Drosophila melanogaster	4-16
26487698-6	2016	TG2 incorporates a glutamine donor peptide to Lys(100) in the C-terminal random coil region of S100A4.	Lysine	46-49	S100 calcium binding protein A4	Homo sapiens	95-101
23673667-6	2013	Mutation of each lysine residue revealed that Lys-35 is the major SUMOylation site on Maf1 and that the deSUMOylase, SENP1, is responsible for controlling Maf1K35 SUMOylation.	Lysine	17-23	MAF1 homolog, negative regulator of RNA polymerase III	Homo sapiens	86-90
23572508-7	2013	HECTD1 ubiquitinated PIPKIgamma90 at lysine 97 and resulted in PIPKIgamma90 degradation.	Lysine	37-43	HECT domain E3 ubiquitin protein ligase 1	Homo sapiens	0-6
26881714-3	2016	As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9).	Lysine	32-38	lysine demethylase 1A	Homo sapiens	61-90
26881714-3	2016	As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9).	Lysine	32-38	lysine demethylase 1A	Homo sapiens	92-96
26881714-3	2016	As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9).	Lysine	61-67	lysine demethylase 1A	Homo sapiens	92-96
26881714-3	2016	As the first identified histone lysine specific demethylase, lysine specific demethylase 1 (LSD1) is classified as a member of monoamine oxidase (MAO) superfamily, and specifically removes mono- and dimethylated histone 3 lysine 4 (H3K4) and H3 lysine 9 (H3K9).	Lysine	61-67	lysine demethylase 1A	Homo sapiens	92-96
23662624-5	2013	The pH value of the solution at which the surface charge of the P(Glu-co-Lys) aggregates reversed could be manipulated by the feed ratio of BLG-NCA and ZLys-NCA.	Lysine	73-76	CEA cell adhesion molecule 6	Homo sapiens	144-147
27246221-1	2016	Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic stem cell aging.	Lysine	31-37	sirtuin 7	Homo sapiens	0-9
27246221-1	2016	Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic stem cell aging.	Lysine	31-37	sirtuin 7	Homo sapiens	11-16
27121714-1	2016	Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., alpha-tubulin, Hsp90 and cortactin.	Lysine	78-84	cortactin	Homo sapiens	162-171
23662624-5	2013	The pH value of the solution at which the surface charge of the P(Glu-co-Lys) aggregates reversed could be manipulated by the feed ratio of BLG-NCA and ZLys-NCA.	Lysine	73-76	CEA cell adhesion molecule 6	Homo sapiens	157-160
26545399-9	2016	The methyltransferase responsible for Lys(79) methylation of human eEF1A is shown to be N6AMT2, previously documented as a putative N(6)-adenine-specific DNA methyltransferase.	Lysine	38-41	EEF1A lysine methyltransferase 1	Homo sapiens	88-94
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	CXXC finger protein 1	Homo sapiens	13-17
27213086-8	2016	Lysine residues from MDM2 played a predominant role.	Lysine	0-6	MDM2 proto-oncogene	Homo sapiens	21-25
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	CXXC finger protein 1	Homo sapiens	19-40
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	lysine methyltransferase 2A	Homo sapiens	43-46
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	lysine methyltransferase 2A	Homo sapiens	48-79
23697932-5	2013	For example, CFP1 (CxxC finger protein 1), MLL (mixed lineage leukaemia protein), KDM (lysine demethylase) 2A and KDM2B regulate lysine methylation on histone tails, whereas TET (ten-eleven translocation) 1 and TET3 hydroxylate methylated cytosine bases.	Lysine	87-93	tet methylcytosine dioxygenase 1	Homo sapiens	179-206
26689258-7	2015	However, when the peptides were mutated on two lysine residues (K15 and K20), the inhibition effects were greatly reduced indicating these two amino acids are key residues for the initial binding of CXCL8 to CXCR1.	Lysine	47-53	C-X-C motif chemokine receptor 1	Homo sapiens	208-213
23329852-2	2013	Focal accumulation of 53BP1 depends on the specific interaction of its tandem Tudor domain with dimethylated lysine 20 in histone H4 (H4K20me2).	Lysine	109-115	tumor protein p53 binding protein 1	Homo sapiens	22-27
26410624-0	2015	Master redox regulator Trx1 upregulates SMYD1 &amp; modulates lysine methylation.	Lysine	62-68	thioredoxin 1	Mus musculus	23-27
23678519-20	2004	A cyclic heptapeptide, cyclo(Cys-Asn-Asn-Ser-Lys-Ser-His-Thr-Cys) (R832), was identified with phage screening against VCAM-1 (12).	Lysine	45-48	vascular cell adhesion molecule 1	Mus musculus	118-124
26410624-0	2015	Master redox regulator Trx1 upregulates SMYD1 &amp; modulates lysine methylation.	Lysine	62-68	SET and MYND domain containing 1	Mus musculus	40-45
26410624-6	2015	The results presented here suggest for the first time that, in addition to being a master redox regulator of protein disulfide bonds and nitrosation, Trx1 may also modulate lysine methylation, a non-redox post-translational modification, via the regulation of SMYD1 expression.	Lysine	173-179	thioredoxin 1	Mus musculus	150-154
23504328-6	2013	The mutation of four lysine residues on Rta that abrogated SUMO-3 conjugation to Rta also decreases the enhancement of the ubiquitination of Rta by RNF4.	Lysine	21-27	ring finger protein 4	Homo sapiens	148-152
25840993-3	2015	We demonstrated here that histone H3 lysine-27 (H3K27) demethylation, predominantly mediated by the H3K27 demethylase Jmjd3, crucially regulated Th17 cell differentiation.	Lysine	37-43	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	118-123
23528241-6	2013	In contrast, in EBV positive cell lines of activated B cell phenotype, and EBV negative BL cell lines the invariably unmethylated 5" regulatory sequences of active miR-146a promoters were enriched in the euchromatic histone modification marks acetylated histone H3, acetylated histone H4, and histone H3 dimethylated at lysine 4.	Lysine	320-326	microRNA 146a	Homo sapiens	164-172
26003568-5	2015	Substrates recognized by the different AlkB homologs comprise erroneous methyl- and etheno adducts in DNA, unique wobble uridine modifications in certain tRNAs, methylated adenines in mRNA, and methylated lysines on proteins.	Lysine	205-212	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	39-43
25400040-5	2015	p28(GANK) interacted with p300 to attenuate assembly of RelA with p300, which lessened acetylation of RelA on the lysine 310 sites.	Lysine	114-120	golgi SNAP receptor complex member 1	Homo sapiens	0-3
23591848-2	2013	Previously, we showed that ATF3, a stress response mediator, can be SUMOylated and lysine 42 is the major SUMO site.	Lysine	83-89	activating transcription factor 3	Homo sapiens	27-31
26264774-7	2015	As glucose-regulated lysine acetylation was predominant in central metabolic pathways and overlapped with acetyl phosphate-regulated acetylation sites, we deleted the major carbon regulator CRP and observed a dramatic loss of acetylation that could be restored by deleting the enzyme that degrades acetyl phosphate.	Lysine	21-27	catabolite gene activator protein	Escherichia coli	190-193
26391951-5	2015	We further show that the principal mechanism for chromatin loading of SMCHD1 involves an LRIF1-mediated interaction with HP1gamma at trimethylated histone H3 lysine 9 (H3K9me3)-modified chromatin sites on the chromosome arms.	Lysine	158-164	ligand dependent nuclear receptor interacting factor 1	Homo sapiens	89-94
23318952-4	2013	The highly conserved p53 Arg(R)-172 is substituted by lysine (K) in Spalax, identical with a tumor-associated mutation.	Lysine	54-60	transformation related protein 53, pseudogene	Mus musculus	21-24
26438600-0	2015	Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism.	Lysine	0-6	cAMP responsive element binding protein 3-like 3	Mus musculus	22-27
26438600-2	2015	Here, we defined a regulatory CREBH posttranslational modification process, namely, lysine-specific acetylation, and its functional involvement in fasting-induced hepatic lipid metabolism.	Lysine	84-90	cAMP responsive element binding protein 3-like 3	Mus musculus	30-35
26438600-5	2015	Site-directed mutagenesis and functional analyses revealed that the lysine (K) residue at position 294 (K294) within the bZIP domain of the CREBH protein is the site where fasting-induced acetylation/deacetylation occurs.	Lysine	68-74	cAMP responsive element binding protein 3-like 3	Mus musculus	140-145
23455153-4	2013	We showed that UBE2O functions as an E2-E3 hybrid to monoubiquitinate SMAD6 at lysine 174 and that the cysteine 885 residue of human UBE2O is necessary for SMAD6 monoubiquitination.	Lysine	79-85	SMAD family member 6	Homo sapiens	70-75
26438600-7	2015	Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor alpha (PPARalpha) in activating their target genes upon fasting or glucagon stimulation.	Lysine	34-40	cAMP responsive element binding protein 3-like 3	Mus musculus	13-18
26438600-7	2015	Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor alpha (PPARalpha) in activating their target genes upon fasting or glucagon stimulation.	Lysine	34-40	cAMP responsive element binding protein 3-like 3	Mus musculus	98-103
26438600-8	2015	Introduction of the CREBH lysine 294 mutation in the liver leads to hepatic steatosis and hyperlipidemia in animals under prolonged fasting.	Lysine	26-32	cAMP responsive element binding protein 3-like 3	Mus musculus	20-25
23478572-3	2013	The challenge now is to understand how this specific chemical modification is written and the Set7 methyltransferase has emerged as a key regulatory enzyme mediating methylation of lysine residues of histone and non-histone proteins.	Lysine	181-187	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	94-98
26596471-4	2015	Mechanistic studies show that SENP1 deletion in adipocytes enhances SUMOylation of the NF-kappaB essential molecule, NEMO, at lysine 277/309, leading to increased NF-kappaB activity, cytokine production and pancreatic inflammation.	Lysine	126-132	inhibitor of kappaB kinase gamma	Mus musculus	117-121
23340989-1	2013	Suv39h1 mediates heterochromatin formation in pericentric and telomeric regions by trimethylation of lysine 9 of histone 3 (H3K9me3).	Lysine	101-107	suppressor of variegation 3-9 1	Mus musculus	0-7
26580206-3	2015	AtMAP18 from Arabidopsis thaliana encoding a microtubule-associated protein with high-lysine content was introduced into the maize genome with the seed-specific promoter F128.	Lysine	86-92	microtubule-associated protein	Arabidopsis thaliana	45-75
23234754-5	2013	TGase2 is a calcium-dependent enzyme that is involved in cross-linking proteins through the formation of epsilon(gamma-glutamyl)-lysine bonds.	Lysine	129-135	transglutaminase 2, C polypeptide	Mus musculus	0-6
26553048-3	2015	We examined the role of chromatin markers such as histone H3 lysine methylation (H3Kme) in TGFbeta1-induced TGFBIp and ECM gene expression in normal and GCD2-derived human corneal fibroblasts.	Lysine	61-67	transforming growth factor beta induced	Homo sapiens	108-114
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Lysine	52-55	melanocortin 4 receptor	Rattus norvegicus	183-206
23524951-5	2013	In this condition, AMBRA1, interacting with the E3-ligase TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its subsequent stabilization, self-association and function.	Lysine	97-100	autophagy and beclin 1 regulator 1	Homo sapiens	19-25
26593415-3	2015	We synthesized an N-palmitoylated peptide Palm-Val-[Lys-Asn-Lys-Asn-Leu-His-Ser-Pro-(Nle)-Tyr-Phe-Phe71-82]-amide-Palm-Val-(71-82) structurally corresponding to cytoplasmic loop 1 of melanocortin 4 receptor (M4R).	Lysine	52-55	melanocortin 4 receptor	Rattus norvegicus	208-211
26470845-2	2015	Here we present data supporting a role for an ASXL1-BAP1 complex in the deubiquitylation of mono-ubiquitylated lysine 119 on Histone H2A (H2AK119ub1) in vivo.	Lysine	111-117	Brca1 associated protein 1	Mus musculus	52-56
23524951-5	2013	In this condition, AMBRA1, interacting with the E3-ligase TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its subsequent stabilization, self-association and function.	Lysine	97-100	TNF receptor associated factor 6	Homo sapiens	58-63
22898212-7	2013	Mass spectral analysis of CBDP-inhibited BChE digested with Glu-C showed an o-hydroxybenzyl adduct (+106 amu) on lysine 499, a residue far from the active site, but not on His-438.	Lysine	113-119	butyrylcholinesterase	Homo sapiens	41-45
26370508-0	2015	Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.	Lysine	11-17	inactive X specific transcripts	Mus musculus	60-64
26370508-0	2015	Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.	Lysine	11-17	inactive X specific transcripts	Mus musculus	136-140
26370508-3	2015	In the absence of Tsix, PRC2-mediated histone H3 lysine 27 trimethylation (H3K27me3) is established over the Xist promoter.	Lysine	49-55	inactive X specific transcripts	Mus musculus	109-113
26370508-5	2015	Here, we identified histone H3 lysine 36 trimethylation (H3K36me3) as a modification that is recruited by Tsix cotranscriptionally and extends over the Xist promoter.	Lysine	31-37	inactive X specific transcripts	Mus musculus	152-156
23123190-6	2013	Mutation of the downstream lysine cluster markedly reduces the H(2)O(2)-induced ASK1-karyopherin alpha2/beta1 interaction and inhibits ASK1 nuclear translocation.	Lysine	27-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	80-84
26437366-1	2015	The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub).	Lysine	132-138	Brca1 associated protein 1	Mus musculus	22-26
26437366-3	2015	Here we demonstrate that Bap1 loss in mice results in increased trimethylated histone H3 lysine 27 (H3K27me3), elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) expression, and enhanced repression of polycomb repressive complex 2 (PRC2) targets.	Lysine	89-95	Brca1 associated protein 1	Mus musculus	25-29
26349765-2	2015	Epigenetic readers, such as the BET domains, are responsible for reading histone lysine acetylation which is a hallmark of open chromatin structure, further providing a scaffold that can be accessed by RNA polymerases as well as transcription factors.	Lysine	81-87	delta/notch-like EGF repeat containing	Mus musculus	32-35
23123190-6	2013	Mutation of the downstream lysine cluster markedly reduces the H(2)O(2)-induced ASK1-karyopherin alpha2/beta1 interaction and inhibits ASK1 nuclear translocation.	Lysine	27-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	135-139
23175188-5	2013	Consistent with this finding, SIRT2 repressed NEDD4 gene expression by directly binding to the NEDD4 gene core promoter and deacetylating histone H4 lysine 16.	Lysine	149-155	sirtuin 2	Homo sapiens	30-35
26266677-0	2015	Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.	Lysine	17-23	carbonic anhydrase 2	Homo sapiens	45-66
26266677-4	2015	Here we present the crystal structures of wild-type and a variant of human carbonic anhydrase II (hCA II) that have been expressed in E. coli and exhibit surface lysine acetylation and we speculate on the effect this has on the conformational stability of each enzyme.	Lysine	162-168	carbonic anhydrase 2	Homo sapiens	75-96
26266677-4	2015	Here we present the crystal structures of wild-type and a variant of human carbonic anhydrase II (hCA II) that have been expressed in E. coli and exhibit surface lysine acetylation and we speculate on the effect this has on the conformational stability of each enzyme.	Lysine	162-168	carbonic anhydrase 2	Homo sapiens	98-104
23175188-5	2013	Consistent with this finding, SIRT2 repressed NEDD4 gene expression by directly binding to the NEDD4 gene core promoter and deacetylating histone H4 lysine 16.	Lysine	149-155	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	46-51
23268205-5	2013	For the sea bass and rabbit PepT1, kinetic parameters, K(0.5) and I(max) and their ratio, show the importance of the position of the charged lysine in the peptide.	Lysine	141-147	solute carrier family 15 member 1	Oryctolagus cuniculus	28-33
27314083-2	2016	We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma.	Lysine	66-72	Kruppel like factor 6	Homo sapiens	21-42
27314083-2	2016	We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma.	Lysine	66-72	Kruppel like factor 6	Homo sapiens	44-48
26448330-0	2015	Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.	Lysine	14-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
26448330-4	2015	A recent study used an antibody-based approach to investigate the methylation of Lys-561 of the stress-inducible Hsp70 protein HSPA1, focusing exclusively on dimethylated HSPA1, concluding that it was elevated in cancer [Cho et al.	Lysine	81-84	heat shock protein family A (Hsp70) member 4	Homo sapiens	113-118
23268205-6	2013	The PepT1 transporter of these species has very low affinity for Lys-Lys and Gly-Lys; this reduces the transport efficiency which is instead higher for Lys-Met and Lys-Gly.	Lysine	65-68	solute carrier family 15 member 1	Oryctolagus cuniculus	4-9
23268205-7	2013	PepT1 from zebrafish showed relatively high affinity and excellent transport efficiency for Met-Lys and Lys-Met.	Lysine	96-99	solute carrier family 15 member 1b	Danio rerio	0-5
23268205-7	2013	PepT1 from zebrafish showed relatively high affinity and excellent transport efficiency for Met-Lys and Lys-Met.	Lysine	104-107	solute carrier family 15 member 1b	Danio rerio	0-5
26401015-1	2015	The Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex hyperacetylates histone tails in vivo in a manner that depends upon histone 3 lysine 4 trimethylation (H3K4me3), a histone mark enriched at promoters of actively transcribed genes.	Lysine	140-146	lysine acetyltransferase 2A	Homo sapiens	12-16
23319590-2	2013	Here an uncharacterized protein, Fbxw15, directly interacts with HBO1, a labile protein (t&amp;frac12; = ~3 h), to mediate its ubiquitination (Lys(338)) and degradation in the cytoplasm.	Lysine	143-146	lysine acetyltransferase 7	Homo sapiens	65-69
26605136-4	2015	To characterize the contribution of this residue toward catalysis, the equivalent lysine in murine ALAS2 was substituted with valine, eliminating the possibility of a hydrogen bond.	Lysine	82-88	aminolevulinic acid synthase 2, erythroid	Mus musculus	99-104
23273925-2	2013	In Arabidopsis, two MYST histone acetyltransferases HAM1 and HAM2 work redundantly to acetylate histone H4 lysine 5 (H4K5ace) in vitro.	Lysine	107-113	histone acetyltransferase of the MYST family 2	Arabidopsis thaliana	61-65
26507377-5	2015	We recently reported that lysine-acetylation regulates nearly all aspects of Ran-function such as RCC1 catalyzed nucleotide exchange, intrinsic nucleotide hydrolysis, its interaction with NTF2 and the formation of import- and export-complexes.	Lysine	26-32	nuclear transport factor 2	Homo sapiens	188-192
22815158-6	2013	Activation of p53 by FK866 involved increased acetylation of p53 at lysine 382 with subsequent increase in the expression of p21 and BAX.	Lysine	68-74	H3 histone pseudogene 16	Homo sapiens	125-128
26239392-2	2015	HLA-C*14:02:13 differs from HLA-C*14:02:01 by a silent G to A substitution at nucleotide position 400 in exon 2, where lysine at position 66 remains unchanged.	Lysine	119-125	major histocompatibility complex, class I, C	Homo sapiens	0-5
23358244-0	2013	Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.	Lysine	70-76	sirtuin 2	Homo sapiens	12-17
25043748-1	2015	Enhancer of zeste homolog 2 (EZH2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and its demethylation is catalyzed by UTX.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
25043748-1	2015	Enhancer of zeste homolog 2 (EZH2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and its demethylation is catalyzed by UTX.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
23358244-9	2013	Therefore, K8 acetylation at Lys-207, a highly conserved residue among type II keratins and other IFs, is up-regulated upon hyperglycemia and down-regulated by SIRT2.	Lysine	29-32	sirtuin 2	Homo sapiens	160-165
23134341-3	2013	Ubiquitin modification of full-length IRF-1 by E3 ligases such as CHIP [C-terminus of the Hsc (heat-shock cognate) 70-interacting protein] and MDM2 (murine double minute 2), which dock to the Mf2 domain, was specific for lysine residues found predominantly in loop structures that extend from the DNA-binding domain, whereas no modification was detected in the more conformationally flexible C-terminal half of the protein.	Lysine	221-227	interferon regulatory factor 1	Mus musculus	38-43
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Lysine	84-87	growth differentiation factor 15	Homo sapiens	17-22
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Lysine	84-87	growth differentiation factor 15	Homo sapiens	23-28
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Lysine	93-96	growth differentiation factor 15	Homo sapiens	17-22
27183783-5	2015	In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly.	Lysine	93-96	growth differentiation factor 15	Homo sapiens	23-28
23134341-3	2013	Ubiquitin modification of full-length IRF-1 by E3 ligases such as CHIP [C-terminus of the Hsc (heat-shock cognate) 70-interacting protein] and MDM2 (murine double minute 2), which dock to the Mf2 domain, was specific for lysine residues found predominantly in loop structures that extend from the DNA-binding domain, whereas no modification was detected in the more conformationally flexible C-terminal half of the protein.	Lysine	221-227	transformed mouse 3T3 cell double minute 2	Mus musculus	143-147
23134341-3	2013	Ubiquitin modification of full-length IRF-1 by E3 ligases such as CHIP [C-terminus of the Hsc (heat-shock cognate) 70-interacting protein] and MDM2 (murine double minute 2), which dock to the Mf2 domain, was specific for lysine residues found predominantly in loop structures that extend from the DNA-binding domain, whereas no modification was detected in the more conformationally flexible C-terminal half of the protein.	Lysine	221-227	transformed mouse 3T3 cell double minute 2	Mus musculus	149-171
23276226-7	2013	Fibroblasts expressing OCT4 had reduced levels of histone 3 lysine 9 or 27 trimethylation (H3K9me3 and H3K27me3, respectively).	Lysine	60-66	POU class 5 homeobox 1	Homo sapiens	23-27
26441991-4	2015	For instance, G9a, a histone methyltransferase responsible for histone H3 lysine 9 (H3K9) mono- and dimethylation, has been observed to be upregulated in different types of cancer and its overexpression has been associated with poor prognosis.	Lysine	74-80	euchromatic histone lysine methyltransferase 2	Homo sapiens	14-17
26366928-0	2015	Dietary L-Lysine Suppresses Autophagic Proteolysis and Stimulates Akt/mTOR Signaling in the Skeletal Muscle of Rats Fed a Low-Protein Diet.	Lysine	8-16	mechanistic target of rapamycin kinase	Rattus norvegicus	70-74
26366928-9	2015	Taken together, supplementation of Lys to a low-protein diet suppresses autophagic proteolysis through the Akt/mTOR signaling pathway, and continuous feeding of a Lys-rich diet may increase skeletal muscle mass.	Lysine	35-38	mechanistic target of rapamycin kinase	Rattus norvegicus	111-115
26391684-1	2015	It has been reported that the Numb protein is methylated at lysine 158 and 163 and that this methylation is introduced by the SET8 protein lysine methyltransferase [Dhami et al., (2013) Molecular Cell 50, 565-576].	Lysine	60-66	NUMB endocytic adaptor protein	Homo sapiens	30-34
23388825-3	2013	Ing1 functions by recruiting the regulator of DNA demethylation growth arrest and DNA damage protein 45a (Gadd45a) to histone H3 trimethylated at Lys 4 (H3K4me3).	Lysine	146-149	inhibitor of growth family member 1	Homo sapiens	0-4
26130719-3	2015	Mechanistic investigation demonstrated that DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 lysine 27 trimethylation (H3K27me3) at the NEDD4L promoter.	Lysine	213-219	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	84-90
23250744-10	2013	The NH(2)-terminal cytoplasmic region of Tat2p containing ubiquitination acceptor lysines interacted with liposomes containing acidic phospholipids, including phosphatidylserine.	Lysine	82-89	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	41-46
26130719-3	2015	Mechanistic investigation demonstrated that DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 lysine 27 trimethylation (H3K27me3) at the NEDD4L promoter.	Lysine	213-219	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	168-174
26130719-3	2015	Mechanistic investigation demonstrated that DDB2 can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 lysine 27 trimethylation (H3K27me3) at the NEDD4L promoter.	Lysine	213-219	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	168-174
23319629-4	2013	The more amino-terminal of its two plant homeodomains (PHDs), PHD1, helps Aire target poorly transcribed loci by "reading" the methylation status of a particular lysine residue of histone-3, a process that does not depend on the more carboxyl-terminal PHD-2.	Lysine	162-168	egl-9 family hypoxia-inducible factor 1	Mus musculus	252-257
26693067-10	2015	By RNA immunoprecipitation and Chromatin immunoprecipitation assay, we demonstrated that LINC01207 could bind with EZH2 and mediated trimethylation of histone 3 lysine 27 at the promoter region of Bad, an important pro-apoptotic gene.	Lysine	161-167	small integral membrane protein 31	Homo sapiens	89-98
23172226-2	2013	In an effort to identify mechanisms that regulate MLK3 activity in beta cells, we discovered that IL-1beta stimulates Lys-63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase.	Lysine	118-121	TNF receptor associated factor 6	Homo sapiens	172-177
26221039-8	2015	Although several Class I and II HDACs interact with MSH2, HDAC10 is the major enzyme that deacetylates MSH2 at Lys-73.	Lysine	111-114	histone deacetylase 10	Homo sapiens	58-64
23148227-8	2013	Furthermore, RUNX1 was associated with p300 histone acetyltransferase, and ADR-dependent acetylation of p53 at Lys-373/382 was markedly inhibited in RUNX1 knockdown cells.	Lysine	111-114	RUNX family transcription factor 1	Homo sapiens	149-154
26260980-1	2015	Aldehyde dehydrogenase 7A1 (ALDH7A1) is part of lysine catabolism and catalyzes the NAD(+)-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	Lysine	48-54	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-26
26260980-1	2015	Aldehyde dehydrogenase 7A1 (ALDH7A1) is part of lysine catabolism and catalyzes the NAD(+)-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	Lysine	48-54	aldehyde dehydrogenase 7 family member A1	Homo sapiens	28-35
23142645-3	2013	HP1 specifically recognizes a methylated lysine residue at position 9 in histone H3 through its N-terminal chromo domain (CD).	Lysine	41-47	chromobox 5	Homo sapiens	0-3
23142645-4	2013	To elucidate the binding properties of HP1alpha to nucleosomes in vitro, we reconstituted nucleosomes containing histone H3 trimethylated at lysine 9.	Lysine	141-147	chromobox 5	Homo sapiens	39-47
26215926-2	2015	Lysine (K)-specific demethylase 5D (KDM5D) is located on the AZFb region of the Y chromosome and encodes a JmjC-domain-containing protein.	Lysine	0-6	lysine demethylase 5D	Homo sapiens	36-41
23289424-8	2013	The SET7/9 methylation sites in H1.4 were pinpointed to the last lysine residues of the six KAK motifs in the C-terminal domain (K121, K129, K159, K171, K177 and K192).	Lysine	65-71	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	4-10
23131550-3	2013	Here, we showed that CHFR is covalently modified by SUMO-1 at lysine 663 and subsequently destabilized by ubiquitin-proteasome system.	Lysine	62-68	checkpoint with forkhead and ring finger domains	Homo sapiens	21-25
26138467-10	2015	This suggests the role of nNOS inhibition and RhoA/ROCK activation in the increase in IAS tone by LY-83583.	Lysine	98-100	nitric oxide synthase 1	Rattus norvegicus	26-30
26138467-10	2015	This suggests the role of nNOS inhibition and RhoA/ROCK activation in the increase in IAS tone by LY-83583.	Lysine	98-100	ras homolog family member A	Rattus norvegicus	46-50
23534753-6	2013	Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34.	Lysine	68-71	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	11-14
26061139-4	2015	Treatment of dairy cow mammary epithelial cells with amino acids (lysine or methionine) increased both cell growth and the expression of beta-casein (CSN2), WISP3, mTOR, and phospho-mTOR (p-mTOR).	Lysine	66-72	WISP3	Bos taurus	157-162
23534753-6	2013	Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34.	Lysine	68-71	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	64-67
23534753-6	2013	Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34.	Lysine	72-75	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	11-14
23534753-6	2013	Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34.	Lysine	72-75	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	64-67
22890573-8	2013	Interestingly, snapin was ubiquitinated by RNF13 via the lysine-29 conjugated polyubiquitin chain, which in turn promoted the association of snapin with SNAP-25.	Lysine	57-63	synaptosomal-associated protein 25	Mus musculus	153-160
26055718-4	2015	Shortening the loop, the lysine/glutamate interchange and the additional Val to Ser substitution all led to Kif2C mutants with decreased microtubule-stimulated ATPase and impaired depolymerization capability.	Lysine	25-31	kinesin family member 2C	Homo sapiens	108-113
23431445-3	2013	Ubiquitination is fundamental to the ERAD process; however, a mutant T-cell receptor alpha (TCRalpha) lacking lysine residues is targeted for the degradation by the ERAD pathway.	Lysine	110-116	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	92-100
26171830-11	2015	PEGylation resulted in the modification of up to eight surface-exposed lysine residues of SO, an increased conformational stability and similar kinetic properties compared with wild-type SO.	Lysine	71-77	sulfite oxidase	Homo sapiens	90-92
23431445-4	2013	We have shown that ubiquitination of lysine-less TCRalpha occurs on internal, non-lysine residues and that the same E3 ligase conjugates ubiquitin to TCRalpha in the presence or absence of lysine residues.	Lysine	37-43	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	49-57
26177453-1	2015	SIRT1 plays a key role in maintaining metabolic homeostasis in mammals by directly modulating the activities of various transcription factors and metabolic enzymes through lysine deacetylation.	Lysine	172-178	sirtuin 1	Homo sapiens	0-5
23431445-4	2013	We have shown that ubiquitination of lysine-less TCRalpha occurs on internal, non-lysine residues and that the same E3 ligase conjugates ubiquitin to TCRalpha in the presence or absence of lysine residues.	Lysine	82-88	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	49-57
26183527-3	2015	Here, we demonstrate that the histone lysine methyltransferase SUV39H2 trimethylated LSD1 on lysine 322.	Lysine	38-44	lysine demethylase 1A	Homo sapiens	85-89
23431445-4	2013	We have shown that ubiquitination of lysine-less TCRalpha occurs on internal, non-lysine residues and that the same E3 ligase conjugates ubiquitin to TCRalpha in the presence or absence of lysine residues.	Lysine	82-88	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	49-57
26183527-7	2015	Our results reveal the regulatory mechanism of LSD1 protein through its lysine methylation by SUV39H2 in human cancer cells.	Lysine	72-78	lysine demethylase 1A	Homo sapiens	47-51
23431445-5	2013	Mass-spectrometry indicates that WT-TCRalpha is ubiquitinated on multiple lysine residues.	Lysine	74-80	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	36-44
23431445-8	2013	In this study, we demonstrate that it is possible to detect both ester and thioester based ubiquitination events, although the exact linkage on lysine-less TCRalpha remains elusive.	Lysine	144-150	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	156-164
23087261-0	2013	Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis.	Lysine	0-6	solute carrier family 22 member 6	Homo sapiens	39-66
25987559-3	2015	Here we demonstrated that PINK1-53 is stabilized in the presence of enhanced Lys-63-linked ubiquitination and identified TRAF6-related NF-kappaB activation as a novel pathway involved in this.	Lysine	77-80	PTEN induced kinase 1	Homo sapiens	26-34
25998125-9	2015	Two lysine residues at the tip of repeat 2-3 beta-hairpin (residues 105-106) are critical for Nav1.2 but not KCNQ3 channel binding.	Lysine	4-10	sodium voltage-gated channel alpha subunit 2	Homo sapiens	94-100
23087261-7	2013	Mass spectroscopy has revealed that ubiquitination of OAT1 consists of polyubiquitin chains, primarily through lysine 48 linkage.	Lysine	111-117	solute carrier family 22 member 6	Homo sapiens	54-58
24287595-3	2013	We uncover lysine 178 in Nck1 as the evolutionarily conserved ubiquitin acceptor site.	Lysine	11-17	NCK adaptor protein 1	Homo sapiens	25-29
26134520-2	2015	We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation and catalytic activation by small molecule sirtuin-activating compounds (STACs).	Lysine	151-157	sirtuin 1	Homo sapiens	65-70
26134520-2	2015	We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation and catalytic activation by small molecule sirtuin-activating compounds (STACs).	Lysine	151-157	sirtuin 1	Homo sapiens	87-93
22971966-2	2013	In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues.	Lysine	139-142	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	85-89
25880615-10	2015	SIGNIFICANCE AND IMPACT OF THE STUDY: Histone deacetylases (HDAC) are epigenetic enzymes that regulate the deacetylation in lysine group on a histone, and thus regulate the gene expression.	Lysine	124-130	histone deacetylase 9	Homo sapiens	38-58
25880615-10	2015	SIGNIFICANCE AND IMPACT OF THE STUDY: Histone deacetylases (HDAC) are epigenetic enzymes that regulate the deacetylation in lysine group on a histone, and thus regulate the gene expression.	Lysine	124-130	histone deacetylase 9	Homo sapiens	60-64
22971966-2	2013	In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues.	Lysine	139-142	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	110-114
23371947-4	2013	SNL1 interacts with HISTONE DEACETYLASE19 in vitro and in planta, and loss-of-function mutants of SNL1 and SNL2 show increased acetylation levels of histone 3 lysine 9/18 (H3K9/18) and H3K14.	Lysine	159-165	SIN3-like 1	Arabidopsis thaliana	0-4
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Lysine	37-40	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	47-53
25573590-9	2015	Compared with subjects having ALDH-2 Lys+ with ADH-1B His/His, ORs and 95%CIs for those with ALDH-2 Glu/Glu and ADH-1B His/His was 3.42(0.57-20.38).	Lysine	37-40	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	112-118
23371947-4	2013	SNL1 interacts with HISTONE DEACETYLASE19 in vitro and in planta, and loss-of-function mutants of SNL1 and SNL2 show increased acetylation levels of histone 3 lysine 9/18 (H3K9/18) and H3K14.	Lysine	159-165	SIN3-like 1	Arabidopsis thaliana	98-102
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Lysine	236-239	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	30-35
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Lysine	236-239	calcium/calmodulin dependent protein kinase I	Homo sapiens	120-130
23469257-2	2013	Set1 catalyzes mono-, di- and trimethylation of the fourth residue, lysine 4, of histone H3 using methyl groups from S-adenosylmethionine, and requires a subset of COMPASS proteins for this activity.	Lysine	68-74	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	0-4
25408501-6	2015	A mutational analysis identified the lysine residue on BAK required for proteolysis, and a functional siRNA screen identified the HECT domain E3 ubiquitin ligase HERC1 as being required for E6-mediated BAK degradation.	Lysine	37-43	BCL2 antagonist/killer 1	Homo sapiens	55-58
25408501-6	2015	A mutational analysis identified the lysine residue on BAK required for proteolysis, and a functional siRNA screen identified the HECT domain E3 ubiquitin ligase HERC1 as being required for E6-mediated BAK degradation.	Lysine	37-43	BCL2 antagonist/killer 1	Homo sapiens	202-205
23505487-6	2013	HP1alpha binds to the genomic region of myogenic genes and depletion of HP1alpha results in a paradoxical increase in histone H3 lysine 9 trimethylation (H3K9me3) at these sites.	Lysine	129-135	chromobox 5	Homo sapiens	0-8
26062444-1	2015	The chromatin-modifying enzyme lysine-specific demethylase 1, KDM1A/LSD1 is involved in maintaining the undifferentiated, malignant phenotype of neuroblastoma cells and its overexpression correlated with aggressive disease, poor differentiation and infaust outcome.	Lysine	31-37	lysine demethylase 1A	Homo sapiens	62-67
26062444-1	2015	The chromatin-modifying enzyme lysine-specific demethylase 1, KDM1A/LSD1 is involved in maintaining the undifferentiated, malignant phenotype of neuroblastoma cells and its overexpression correlated with aggressive disease, poor differentiation and infaust outcome.	Lysine	31-37	lysine demethylase 1A	Homo sapiens	68-72
23505487-6	2013	HP1alpha binds to the genomic region of myogenic genes and depletion of HP1alpha results in a paradoxical increase in histone H3 lysine 9 trimethylation (H3K9me3) at these sites.	Lysine	129-135	chromobox 5	Homo sapiens	72-80
26061460-7	2015	Interestingly, USP15 specifically removed lysine 63-linked polyubiquitin chains from RIG-I among the essential components in RIG-I-like receptor-dependent pathway.	Lysine	42-48	DExD/H-box helicase 58	Homo sapiens	85-90
26061460-7	2015	Interestingly, USP15 specifically removed lysine 63-linked polyubiquitin chains from RIG-I among the essential components in RIG-I-like receptor-dependent pathway.	Lysine	42-48	DExD/H-box helicase 58	Homo sapiens	125-130
23105103-9	2012	Promoter swapping and site-directed mutagenesis of GDH1 and GDH3 indicated that the necessity of GDH3 for the resistance to stress-induced apoptosis and chronological aging is due to the stationary phase-specific expression of GDH3 and concurrent degradation of Gdh1 in which the Lys-426 residue plays an essential role.	Lysine	280-283	glutamate dehydrogenase (NADP(+)) GDH1	Saccharomyces cerevisiae S288C	51-55
26060329-5	2015	We hypothesized that constitutive SUMO2 conjugation and deconjugation occurred basally and that arsenic trioxide treatment caused the exchange of SUMO2 for SUMO1 on a fraction of Lys(65) in PML.	Lysine	179-182	small ubiquitin like modifier 2	Homo sapiens	146-151
26060329-6	2015	On the basis of data obtained with mutational analysis and quantitative proteomics, we propose that the SUMO switch at Lys(65) of PML enhanced nuclear body formation, subsequent SUMO2 conjugation to Lys(160), and consequent RNF4-dependent ubiquitylation of PML.	Lysine	119-122	small ubiquitin like modifier 2	Homo sapiens	178-183
23169648-5	2012	TRIM28 binds to Ealpha and induces histone 3 lysine 4 trimethylation in the Ealpha and distant regions of the TCRalpha locus, coupled with recruitment of Rag proteins.	Lysine	45-51	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	110-118
25256819-4	2015	In this study, novel VEGF-loaded heparin/poly-L-lysine (Hep/PLL) particles were developed and immobilized on a dopamine coated titanium surface.	Lysine	41-54	DNL-type zinc finger	Homo sapiens	56-59
23076824-3	2012	Upon UV irradiation, the DNA sliding clamp PCNA is monoubiquitylated on its conserved Lys-164.	Lysine	86-89	proliferating cell nuclear antigen	Homo sapiens	43-47
25996949-11	2015	Likewise, LMP1 or TRAF1 complexes purified from LCLs were decorated by lysine 63 (K63)-linked polyubiqutin chains.	Lysine	71-77	PDZ and LIM domain 7	Homo sapiens	10-14
23078624-4	2012	MDA-7/IL-24 contains 10 lysine sites: K63, K69, K78, K119, K123, K136, K179, K189, K203, and K206.	Lysine	24-30	interleukin 24	Homo sapiens	6-11
25976611-3	2015	We show that the eukaryotic protein CDC123 defines a novel clade of ATP-grasp enzymes distinguished from all other members of the superfamily by a RAGNYA domain with two conserved lysines (henceforth the R2K clade).	Lysine	180-187	cell division cycle 123	Homo sapiens	36-42
23078624-5	2012	Site-directed mutagenesis in these sites reveals that lysine 123 is the major internal lysine involvement of MDA-7/IL-24 ubiquitination.	Lysine	54-60	interleukin 24	Homo sapiens	109-114
23078624-5	2012	Site-directed mutagenesis in these sites reveals that lysine 123 is the major internal lysine involvement of MDA-7/IL-24 ubiquitination.	Lysine	54-60	interleukin 24	Homo sapiens	115-120
23078624-5	2012	Site-directed mutagenesis in these sites reveals that lysine 123 is the major internal lysine involvement of MDA-7/IL-24 ubiquitination.	Lysine	87-93	interleukin 24	Homo sapiens	109-114
25770209-0	2015	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3zeta via deacetylation of lysines within the 14-3-3zeta binding pocket.	Lysine	100-107	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	68-78
23078624-5	2012	Site-directed mutagenesis in these sites reveals that lysine 123 is the major internal lysine involvement of MDA-7/IL-24 ubiquitination.	Lysine	87-93	interleukin 24	Homo sapiens	115-120
25770209-0	2015	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3zeta via deacetylation of lysines within the 14-3-3zeta binding pocket.	Lysine	100-107	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	119-129
25770209-2	2015	We show here that lysines within the 14-3-3zeta binding pocket and protein-protein interface can be modified by acetylation.	Lysine	18-25	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	37-47
23078624-9	2012	Together, lysine 123 is mainly implicated in the ubiquitination and degradation of MDA-7/IL-24.	Lysine	10-16	interleukin 24	Homo sapiens	83-88
23078624-9	2012	Together, lysine 123 is mainly implicated in the ubiquitination and degradation of MDA-7/IL-24.	Lysine	10-16	interleukin 24	Homo sapiens	89-94
23078624-10	2012	Inhibition of degradation and ubiquitination of MDA-7/IL-24 through mutation of lysine 123 result in enhanced stability of MDA-7/IL-24 and exhibits persistent tumor suppression activity compared with the wild type.	Lysine	80-86	interleukin 24	Homo sapiens	48-53
23078624-10	2012	Inhibition of degradation and ubiquitination of MDA-7/IL-24 through mutation of lysine 123 result in enhanced stability of MDA-7/IL-24 and exhibits persistent tumor suppression activity compared with the wild type.	Lysine	80-86	interleukin 24	Homo sapiens	54-59
23078624-10	2012	Inhibition of degradation and ubiquitination of MDA-7/IL-24 through mutation of lysine 123 result in enhanced stability of MDA-7/IL-24 and exhibits persistent tumor suppression activity compared with the wild type.	Lysine	80-86	interleukin 24	Homo sapiens	123-128
25960197-3	2015	The interaction between the two proteins is primarily mediated by an acidic pocket in USP7 and Lysine residues within DNMT1"s KG linker.	Lysine	95-101	DNA methyltransferase 1	Homo sapiens	118-123
25960197-5	2015	Acetylation of the KG linker Lysine residues impair DNMT1-USP7 interaction and promote the degradation of DNMT1.	Lysine	29-35	DNA methyltransferase 1	Homo sapiens	52-57
23078624-10	2012	Inhibition of degradation and ubiquitination of MDA-7/IL-24 through mutation of lysine 123 result in enhanced stability of MDA-7/IL-24 and exhibits persistent tumor suppression activity compared with the wild type.	Lysine	80-86	interleukin 24	Homo sapiens	129-134
25960197-5	2015	Acetylation of the KG linker Lysine residues impair DNMT1-USP7 interaction and promote the degradation of DNMT1.	Lysine	29-35	ubiquitin specific peptidase 7	Homo sapiens	58-62
25960197-5	2015	Acetylation of the KG linker Lysine residues impair DNMT1-USP7 interaction and promote the degradation of DNMT1.	Lysine	29-35	DNA methyltransferase 1	Homo sapiens	106-111
22444501-4	2012	Hepatic activation of HMGCR gene transcription in LP piglets was associated with promoter hypomethylation, together with decreased histone H3, H3 lysine 9 monomethylation (H3K9me1) and H3 lysine 27 trimethylation (H3K27me3) and increased H3 acetylation.	Lysine	146-152	3-hydroxy-3-methylglutaryl-CoA reductase	Sus scrofa	22-27
22444501-4	2012	Hepatic activation of HMGCR gene transcription in LP piglets was associated with promoter hypomethylation, together with decreased histone H3, H3 lysine 9 monomethylation (H3K9me1) and H3 lysine 27 trimethylation (H3K27me3) and increased H3 acetylation.	Lysine	188-194	3-hydroxy-3-methylglutaryl-CoA reductase	Sus scrofa	22-27
25596560-5	2015	Notably, MTT assays showed that DOX-loaded crosslinked HA-Lys-LA10 nanoparticles possessed an apparent targetability and a superior antitumor activity toward CD44 receptor overexpressing DOX-resistant MCF-7 human breast cancer cells (MCF-7/ADR).	Lysine	58-61	CD44 molecule (Indian blood group)	Homo sapiens	158-162
23103942-2	2012	Through crystallographic snapshots and mechanism-inspired chemical probes, we define how human OGT recognizes the sugar donor and acceptor peptide and uses a new catalytic mechanism of glycosyl transfer, involving the sugar donor alpha-phosphate as the catalytic base as well as an essential lysine.	Lysine	292-298	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	95-98
25103872-1	2015	The lysyl oxidase (LOX) family of proteins (LOX and LOXL1-LOXL4) oxidize amino groups located in the epsilon-position in lysines to generate an aldehyde group.	Lysine	121-128	lysyl oxidase	Homo sapiens	4-17
25103872-1	2015	The lysyl oxidase (LOX) family of proteins (LOX and LOXL1-LOXL4) oxidize amino groups located in the epsilon-position in lysines to generate an aldehyde group.	Lysine	121-128	lysyl oxidase	Homo sapiens	19-22
25103872-1	2015	The lysyl oxidase (LOX) family of proteins (LOX and LOXL1-LOXL4) oxidize amino groups located in the epsilon-position in lysines to generate an aldehyde group.	Lysine	121-128	lysyl oxidase	Homo sapiens	44-47
23071318-2	2012	alpha-Tubulin is specifically acetylated on lysine 40, a modification that serves to stabilize microtubules of axons and cilia.	Lysine	44-50	tubulin alpha 1b	Homo sapiens	0-13
25716581-11	2015	The induction of Pepck gene expression in females was associated with increased dimethylated histone H3 lysine 4 level in multiple regions of the gene.	Lysine	104-110	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	17-22
23063513-2	2012	Here we describe a new ShK analogue with an additional C-terminus Lys residue and amide.	Lysine	66-69	sedoheptulokinase	Homo sapiens	23-26
25649769-6	2015	In contrast, during LSD1 inhibition, a set of mitochondrial metabolism genes was activated with the concomitant increase of methylated histone H3 at lysine 4 in the promoter regions.	Lysine	149-155	lysine demethylase 1A	Homo sapiens	20-24
25697176-5	2015	In addition, we discovered that the N-terminal domain of Ctf4, necessary for the interaction of Ctf4 with Mms22, an adaptor protein of the Rtt101-Mms1 E3 ubiquitin ligase, is required for the function of the H3 lysine 56 acetylation pathway, suggesting that replicative stress promotes the interaction between Ctf4 and Mms22.	Lysine	211-217	Mms22p	Saccharomyces cerevisiae S288C	106-111
25697176-5	2015	In addition, we discovered that the N-terminal domain of Ctf4, necessary for the interaction of Ctf4 with Mms22, an adaptor protein of the Rtt101-Mms1 E3 ubiquitin ligase, is required for the function of the H3 lysine 56 acetylation pathway, suggesting that replicative stress promotes the interaction between Ctf4 and Mms22.	Lysine	211-217	Mms22p	Saccharomyces cerevisiae S288C	319-324
24367204-13	2012	Incremental cost-effectiveness ratios of LAP/CAP over CAP were R$186,563 for LYs, R$226,403 for PFYs, and R$284,864 for QALYs.	Lysine	77-80	LAP	Homo sapiens	41-44
25652587-1	2015	UNLABELLED: Jumonji domain-containing protein 3 (JMJD3/KDM6B) demethylates lysine 27 on histone H3 (H3K27me3), a repressive epigenetic mark controlling chromatin organization and cellular senescence.	Lysine	75-81	lysine demethylase 6B	Homo sapiens	49-54
25652587-1	2015	UNLABELLED: Jumonji domain-containing protein 3 (JMJD3/KDM6B) demethylates lysine 27 on histone H3 (H3K27me3), a repressive epigenetic mark controlling chromatin organization and cellular senescence.	Lysine	75-81	lysine demethylase 6B	Homo sapiens	55-60
23091041-5	2012	Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope-DR52c complex, the interface is dominated by the TCR Vbeta CDR3 interaction with the p7 lysine.	Lysine	231-237	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	12-15
25749385-5	2015	We found that G9a, a histone methyltransferase, interacts with Snail and mediates Snail-induced transcriptional repression of E-cadherin and EMT, through methylation of histone H3 lysine-9 (H3K9).	Lysine	180-186	euchromatic histone lysine methyltransferase 2	Homo sapiens	14-17
23091041-5	2012	Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope-DR52c complex, the interface is dominated by the TCR Vbeta CDR3 interaction with the p7 lysine.	Lysine	231-237	cerebellar degeneration related protein 1	Homo sapiens	65-70
23091041-7	2012	We suggest that the mimotope p7 lysine mimics Ni(++) in the natural TCR ligand and that MHCII beta-chain flexibility in the area around the peptide p7 position forms a common site for cation binding in metal allergies.	Lysine	32-38	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	68-71
22955279-7	2012	Lys-138 either in both subunits or in p51 alone abrogated the negative effect of p66(184I) by restoring dNTP binding.	Lysine	0-3	tumor protein p63	Homo sapiens	38-41
25712528-4	2015	Here, we found that NDRG1 is posttranslationally modified by Small Ubiquitin-like Modifier (SUMO), preferentially by SUMO-2, and the major SUMO acceptor site of NDRG1 is Lys 14.	Lysine	170-173	N-myc downstream regulated 1	Homo sapiens	20-25
25712528-4	2015	Here, we found that NDRG1 is posttranslationally modified by Small Ubiquitin-like Modifier (SUMO), preferentially by SUMO-2, and the major SUMO acceptor site of NDRG1 is Lys 14.	Lysine	170-173	N-myc downstream regulated 1	Homo sapiens	161-166
25391294-6	2015	Using both biochemical and FRET-/FLIM-based approaches, we demonstrated that SUMO2 is robustly conjugated to p35 in cells and identified the two major SUMO acceptor lysines in p35, K246 and K290.	Lysine	165-172	small ubiquitin like modifier 2	Homo sapiens	77-82
22955279-7	2012	Lys-138 either in both subunits or in p51 alone abrogated the negative effect of p66(184I) by restoring dNTP binding.	Lysine	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	81-84
22403019-5	2012	Apoptosis induced by high Lysine was no longer observed after addition of caspase-9 and caspase-3 inhibitors while caspase-8 inhibitor had no protective effect.	Lysine	26-32	caspase 9	Homo sapiens	74-83
22403019-6	2012	High Lysine induced elevations in ROS generation and NADPH oxidase subunits mRNAs (p22 (phox) +106 +- 23%, p67 (phox) +108 +- 22% and gp91 (phox) +75 +- 4% p &lt; 0.05-0.01).	Lysine	5-11	calcineurin like EF-hand protein 1	Homo sapiens	83-86
22998786-4	2012	On-resin ring closing metathesis (RCM) on the olefinic side chains of allylglycine residues and lysine moieties functionalized with an allyloxycarbonyl (Alloc) group, was used to prepare novel carba-bridged surrogates of the disulfide bridge between Cys/2 and Cys/7 in amylin-(1-8).	Lysine	96-102	islet amyloid polypeptide	Rattus norvegicus	269-275
25620559-4	2015	We identified a yeast vacuolar amino acid transporter, Ypq1, that is selectively sorted and degraded in the vacuolar lumen following lysine withdrawal.	Lysine	133-139	cationic amino acid transporter	Saccharomyces cerevisiae S288C	55-59
25988170-4	2015	However, specific ubiquitination at lysine 117 in the Josephin domain activates ataxin-3 through an unknown mechanism.	Lysine	36-42	ataxin 3	Homo sapiens	80-88
25471371-0	2015	Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.	Lysine	100-103	ubiquitin conjugating enzyme E2 G1	Homo sapiens	54-60
22683437-2	2012	Other individual reports identified lysine acetylation as a PTM regulating transcription factors and co-activators including p53, c-Myc, PGC1alpha and Ku70.	Lysine	36-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	130-135
25471371-0	2015	Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.	Lysine	100-103	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	65-71
25471371-2	2015	Although both E2s contain essential acidic loops, only Ube2r1 requires an additional C-terminal extension (184-196) for efficient Lys-48-ubiquitylation activity.	Lysine	130-133	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	55-61
25471371-3	2015	The presence of Tyr-102 and Tyr-104 in the Ube2g1 acidic loop enhanced both ubiquitin binding and Lys-48-ubiquitylation and distinguished Ube2g1 from the otherwise similar truncated Ube2r1(1-183) (Ube2r1C).	Lysine	98-101	ubiquitin conjugating enzyme E2 G1	Homo sapiens	43-49
25471371-4	2015	Replacement of Gln-105-Ser-106-Gly-107 in the acidic loop of Ube2r1C (Ube2r1C(YGY)) by the corresponding residues from Ube2g1 (Tyr-102-Gly-103-Tyr-104) increased Lys-48-ubiquitylation activity and ubiquitin binding.	Lysine	162-165	ubiquitin conjugating enzyme E2 G1	Homo sapiens	119-125
25505263-5	2015	Acetyl mutagenesis of Hsp10 lysine 56 alters Hsp10-Hsp60 binding, conformation, and protein folding.	Lysine	28-34	heat shock protein family D (Hsp60) member 1	Homo sapiens	51-56
2515192-9	1989	A synthetic peptide, containing six consecutive lysines at the carboxy terminus of the human c-Ki-ras 2 protein, also regulated the two enzyme activities at micromolar concentrations.	Lysine	48-55	KRAS proto-oncogene, GTPase	Homo sapiens	93-103
2515193-5	1989	Differences in amino acid sequence were found at positions 43 and 77 among the pepsinogen A isozymogens; the residue at position 43 was Lys in PGA-5, PGA-4, and PGA-3a, and Glu in PGA-3 and PGA-2, and the residue at position 77 was Leu in PGA-5 and PGA-4 and Val in PGA-3 and PGA-2.	Lysine	136-139	pepsinogen A5	Homo sapiens	143-148
23085658-8	2012	Ubiquitin containing only lysine-27 mediated PCSK9 ubiquitination by c-IAP1.	Lysine	26-32	proprotein convertase subtilisin/kexin type 9	Mus musculus	45-50
2683784-5	1989	Sequences coding for the hydrophobic regions, responsible for the elastic properties of the molecule, and the alanine-lysine rich regions, responsible for crosslink formation between molecules, reside in separate exons and alternate for the most part in the elastin gene.	Lysine	118-124	elastin	Homo sapiens	258-265
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	DDB1 and CUL4 associated factor 1	Homo sapiens	49-54
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	DDB1 and CUL4 associated factor 1	Homo sapiens	88-93
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	damage specific DNA binding protein 1	Homo sapiens	94-98
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	ring-box 1	Homo sapiens	104-108
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	Cbl proto-oncogene like 2	Homo sapiens	109-128
25557551-5	2015	Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.	Lysine	165-171	DDB1 and CUL4 associated factor 1	Homo sapiens	88-93
2552299-1	1989	Novel antibodies were raised against a synthetic NH2-terminal myristoyl(Myr-) tetrapeptide(N-Myr-Gly-Ser-Ser-Lys) which is characteristic of an NH2-terminal portion of pp60v-src, the transforming protein of Rous sarcoma virus.	Lysine	109-112	p60 src	Rous sarcoma virus	174-177
23085658-8	2012	Ubiquitin containing only lysine-27 mediated PCSK9 ubiquitination by c-IAP1.	Lysine	26-32	baculoviral IAP repeat-containing 3	Mus musculus	69-75
22902629-12	2012	These results explain an earlier finding that individual arginines and lysines inside human PCNA are essential for polymerase delta processivity (Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.	Lysine	71-78	proliferating cell nuclear antigen	Homo sapiens	92-96
2501305-1	1989	We have reacted acrolein with human carbonic anhydrase II using conditions reported to result in maximal formylethylation of exposed histidine and lysine residues (Pocker, Y., and Janjic, N. (1988) J. Biol.	Lysine	147-153	carbonic anhydrase 2	Homo sapiens	36-57
25575817-2	2015	In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP.	Lysine	44-50	lysine demethylase 5A	Homo sapiens	102-107
22902629-12	2012	These results explain an earlier finding that individual arginines and lysines inside human PCNA are essential for polymerase delta processivity (Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.	Lysine	71-78	proliferating cell nuclear antigen	Homo sapiens	306-340
23000965-4	2012	During unperturbed S phase, chromatin-associated PAF15 is modified by double mono-ubiquitylation of Lys 15 and 24 templated through PCNA binding.	Lysine	100-103	PCNA clamp associated factor	Homo sapiens	49-54
25205713-9	2015	Arg and Lys residues located within the 40 residue spanning connecting peptide of fetuin-A were identified as cleavage sites for matriptase-2.	Lysine	8-11	alpha-2-HS-glycoprotein	Mus musculus	82-90
24947323-0	2015	The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE).	Lysine	99-102	MAGE family member D1	Homo sapiens	173-178
24947323-5	2015	We found that FBXO7 interacts with NRAGE and mediates Lys-63-linked poly-ubiquitination of NRAGE in mammalian cells.	Lysine	54-57	MAGE family member D1	Homo sapiens	91-96
2928342-15	1989	Sequence information revealed that the carboxyl-terminal region of the NF-H peptide contained a unique serine-, proline-, alanine-, glutamic acid-, and lysine-rich repeat.	Lysine	152-158	neurofilament heavy chain	Rattus norvegicus	71-75
23000965-4	2012	During unperturbed S phase, chromatin-associated PAF15 is modified by double mono-ubiquitylation of Lys 15 and 24 templated through PCNA binding.	Lysine	100-103	proliferating cell nuclear antigen	Homo sapiens	132-136
23000965-5	2012	Replication blocks trigger rapid, proteasome-dependent removal of Lys 15/24-ubiquitylated PAF15 from PCNA, facilitating bypass of replication-fork-blocking lesions by allowing recruitment of translesion DNA synthesis polymerase poleta to mono-ubiquitylated PCNA at stalled replisomes.	Lysine	66-69	PCNA clamp associated factor	Homo sapiens	90-95
23000965-5	2012	Replication blocks trigger rapid, proteasome-dependent removal of Lys 15/24-ubiquitylated PAF15 from PCNA, facilitating bypass of replication-fork-blocking lesions by allowing recruitment of translesion DNA synthesis polymerase poleta to mono-ubiquitylated PCNA at stalled replisomes.	Lysine	66-69	proliferating cell nuclear antigen	Homo sapiens	101-105
2466697-3	1989	C-terminal lysine residues are involved in plasmin binding to cells, since treatment of cells with carboxypeptidase B decreases this binding by 50%.	Lysine	11-17	carboxypeptidase B1	Homo sapiens	99-117
26697838-4	2015	Furthermore, we discovered that Skp2 could interact with Aurora B and trigger Aurora B Lysine (K) 63-linked ubiquitination.	Lysine	87-93	aurora kinase B	Homo sapiens	78-86
23000965-5	2012	Replication blocks trigger rapid, proteasome-dependent removal of Lys 15/24-ubiquitylated PAF15 from PCNA, facilitating bypass of replication-fork-blocking lesions by allowing recruitment of translesion DNA synthesis polymerase poleta to mono-ubiquitylated PCNA at stalled replisomes.	Lysine	66-69	proliferating cell nuclear antigen	Homo sapiens	257-261
26303949-5	2015	RESULTS: We found that overexpression of KDM6B, a demethylase that acts on histone H3 at lysine 27 (H3K27), inhibited cell growth by initiating mitochondria-dependent apoptosis and by attenuating the invasion-metastasis cascade in NSCLC cells.	Lysine	89-95	lysine demethylase 6B	Homo sapiens	41-46
22815475-1	2012	Binding of heterochromatin protein 1 (HP1) to the histone H3 lysine 9 trimethylation (H3K9me3) mark is a hallmark of establishment and maintenance of heterochromatin.	Lysine	61-67	chromobox 5	Homo sapiens	11-36
22728135-3	2012	Both assays identify a cluster of lysine and arginine residues as important for myosin polymerization in vitro.	Lysine	34-40	myosin heavy chain 14	Homo sapiens	80-86
26111032-3	2015	A rapidly growing number of reports have implicated the FAD-dependent lysine specific demethylase (KDM1) family in cancer, and several small-molecule inhibitors are in development for the treatment of cancer.	Lysine	70-76	lysine demethylase 1A	Homo sapiens	99-103
24940804-4	2015	Proteomic analysis showed that SIRT1 deacetylates HMGB1 at four lysine residues (55, 88, 90, and 177) within the proinflammatory and nuclear localization signal domains of HMGB1.	Lysine	64-70	sirtuin 1	Homo sapiens	31-36
2542205-2	1989	Among 34 tissues specimens surgically resected from 30 patients and 5 cell lines of human HCC, only two had ras point mutations; in one case, codon 12 of c-Ki-ras was altered from GGT, coding glycine, to GTT, coding valine; in the other case, codon 61 of N-ras was altered from CAA, coding glutamine, to AAA, coding lysine.	Lysine	316-322	KRAS proto-oncogene, GTPase	Homo sapiens	154-162
22836579-5	2012	The lysine residues in E2F-1 targeted for NEDDylation can also be methylated, pointing to a possible interplay between these modifications.	Lysine	4-10	E2F transcription factor 1	Homo sapiens	23-28
2493149-1	1989	The opaque-2 gene was shown years ago to increase the nitrogen, lysine, and tryptophan contents of maize and to markedly increase its nutritional value for small children.	Lysine	64-70	regulatory protein opaque-2	Zea mays	4-12
25488809-4	2015	We have identified the histone H3 lysine 9 mono- and di-methyl demethylase enzyme KDM3A as a positive regulator of ER activity.	Lysine	34-40	lysine demethylase 3A	Homo sapiens	82-87
26305287-7	2015	We then used chromatin immunoprecipitation (ChIP) and quantitative RT-PCR to measure histone 3 lysine 9/14 acetylation associated with bdnf promoters I and IV and the reelin promoter in the adult mPFC.	Lysine	95-101	brain derived neurotrophic factor	Homo sapiens	135-139
22718764-5	2012	Using in vitro bulk polymerization assays, we show that the Lys-118 mutations notably reduce actin + Arp2/3 polymerization rates compared with WT.	Lysine	60-63	actin related protein 2	Homo sapiens	101-105
32262215-3	2014	Cationic poly-l-lysine-graft-imidazole (PLI) with a reactive silane moiety was stably immobilized onto the surface of the assembled manganese ferrite nanoparticles (MFs) through an emulsion process, ensuring high water solubility, enhanced MR contrast effect, and endosome-disrupting functionality.	Lysine	9-22	serpin family F member 2	Homo sapiens	40-43
2919891-5	1989	Chemiluminescence by zymosan showed a significant increase after MDP-Lys (L 18) treatment.	Lysine	69-72	ribosomal protein L18	Homo sapiens	74-78
2475147-3	1989	We identified the NF-H multi-phosphorylation repeat domain, i.e. repeats of Lys-Ser-Pro-X (where X is a small uncharged amino acid and Ser acts as a phosphate acceptor), as the determinant recognized by 15/16 MAbs that detected NFTs in sections of AD hippocampus, and 11 of the same 16 MAbs recognised NF-M multi-phosphorylation repeats.	Lysine	76-79	neurofilament medium chain	Homo sapiens	302-306
25359778-6	2014	In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages.	Lysine	124-127	ubiquitin specific peptidase 28	Homo sapiens	82-87
22718764-7	2012	These results highlight a previously unknown role for the Lys-118 residue in the actin-Arp2/3 interaction and also further suggest that Lys-118 may play a more significant role in intra- and intermonomer interactions than was initially hypothesized.	Lysine	58-61	actin related protein 2	Homo sapiens	87-91
25359778-6	2014	In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages.	Lysine	133-136	ubiquitin specific peptidase 28	Homo sapiens	82-87
25359778-6	2014	In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages.	Lysine	133-136	ubiquitin specific peptidase 28	Homo sapiens	82-87
22718764-7	2012	These results highlight a previously unknown role for the Lys-118 residue in the actin-Arp2/3 interaction and also further suggest that Lys-118 may play a more significant role in intra- and intermonomer interactions than was initially hypothesized.	Lysine	136-139	actin related protein 2	Homo sapiens	87-91
2598662-1	1989	The major, non-amelogenin protein component (enamelin) present in EDTA or EDTA-GU HCl extracts of developing bovine enamel has a molecular weight of approximately 67 kD and an amino acid composition rich in asp, glu, ala, leuc and lys.	Lysine	231-234	enamelin	Bos taurus	45-53
22887157-4	2012	Dihydrodipicolinate synthase is the key enzyme involved in the regulatory step for lysine biosynthesis.	Lysine	83-89	dihydrodipicolinate synthase	Escherichia coli	0-28
2535487-4	1989	The binding and specific endocytosis of poly-L-lysine substituted with several mannose derivatives and gluconoyl residues (GlcAx-, Man(y)-PLK) have been determined by a quantitative flow cytometry analysis.	Lysine	40-53	polo like kinase 1	Homo sapiens	138-141
25492968-9	2014	In particular, we focus on HDAC2, which plays a central role in coupling lysine acetylation to synaptic plasticity and mediates many of the effects of HDAC inhibition in cognition and disease.	Lysine	73-79	histone deacetylase 9	Homo sapiens	27-31
25456412-1	2014	DPY-30 is a subunit of mammalian COMPASS-like complexes (complex of proteins associated with Set1) and regulates global histone H3 Lys-4 trimethylation.	Lysine	131-134	dpy-30 histone methyltransferase complex regulatory subunit	Homo sapiens	0-6
22595241-1	2012	The Rtf1 subunit of the Paf1 complex is required for specific histone modifications, including histone H2B lysine 123 monoubiquitylation.	Lysine	107-113	Rtf1p	Saccharomyces cerevisiae S288C	4-8
25362540-5	2014	Finally, a biochemical and proteomic approach allowed to enrich eight out of 12 members of the annexin family and to identify an original annexin A1 cleavage site localized between Ser(28) and Lys(29).	Lysine	193-196	annexin A1	Homo sapiens	138-148
2466482-1	1988	The conformation of reduced bovine pancreatic trypsin inhibitor (R-BPTI) under reducing conditions was monitored by measurements of nonradiative excitation energy-transfer efficiencies (E) between a donor probe attached to the N-terminal Arg1 residue and an acceptor attached to one of the lysine residues (15, 26, 41, or 46) [Amir, D., &amp; Haas, E. (1987) Biochemistry 26, 2162-2175].	Lysine	290-296	spleen trypsin inhibitor I	Bos taurus	67-71
3145738-8	1988	A similar modification of ETF caused a large increase in the apparent Michaelis constant of ETF-Q ox for modified ETF owing to the loss of positive charge on some critical lysines of ETF.	Lysine	172-179	electron transfer flavoprotein dehydrogenase	Homo sapiens	92-100
22639343-8	2012	The best-characterised enzyme is the lysine specific Set7 methyltransferase.	Lysine	37-43	KMT5A pseudogene 1	Homo sapiens	53-57
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	Lysine	137-143	transaldolase 1	Homo sapiens	87-100
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	Lysine	137-143	transaldolase 1	Homo sapiens	335-348
25184342-2	2014	Here we show an essential protective role of the l-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant-linoleic acid hydroperoxide (LoaOOH), by means of transcriptomic profiling and phenotypic analysis, and using the deletion mutant dal80  and lysine auxotroph lys1 .	Lysine	49-57	Dal80p	Saccharomyces cerevisiae S288C	284-289
25184342-2	2014	Here we show an essential protective role of the l-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant-linoleic acid hydroperoxide (LoaOOH), by means of transcriptomic profiling and phenotypic analysis, and using the deletion mutant dal80  and lysine auxotroph lys1 .	Lysine	49-57	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	312-316
25184342-2	2014	Here we show an essential protective role of the l-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant-linoleic acid hydroperoxide (LoaOOH), by means of transcriptomic profiling and phenotypic analysis, and using the deletion mutant dal80  and lysine auxotroph lys1 .	Lysine	51-57	Dal80p	Saccharomyces cerevisiae S288C	284-289
25184342-2	2014	Here we show an essential protective role of the l-lysine biosynthesis pathway in response to the oxidative stress condition induced by the lipid oxidant-linoleic acid hydroperoxide (LoaOOH), by means of transcriptomic profiling and phenotypic analysis, and using the deletion mutant dal80  and lysine auxotroph lys1 .	Lysine	51-57	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	312-316
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	60-64
2901984-5	1988	This confirms a study at the DNA level by our group [16] suggesting a Glu greater than Lys mutation at position 43 in the activation segment of PGA-5.	Lysine	87-90	pepsinogen A5	Homo sapiens	144-149
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	78-82
22679021-0	2012	Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.	Lysine	19-22	ubiquitin conjugating enzyme E2 N	Homo sapiens	159-164
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	91-96
25184342-3	2014	A comprehensive up-regulation of lysine biosynthetic genes (LYS1, LYS2, LYS4, LYS9, LYS12, LYS20 and LYS21) was revealed in dal80Delta following the oxidant challenge.	Lysine	33-39	homocitrate synthase LYS21	Saccharomyces cerevisiae S288C	101-106
25184342-4	2014	The lysine auxotroph (lys1 ) exhibited a significant decrease in growth compared with that of BY4743 upon exposure to LoaOOH, albeit with the sufficient provision of lysine in the medium.	Lysine	4-10	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	22-26
2900138-6	1988	T1 is related to TC1, and has the structure: Ser-Ser(P)-Met-Ser-Gly-Leu-His-Leu-Val-Lys.	Lysine	84-87	Serum cholesterol level QTL 22	Rattus norvegicus	17-20
22679021-1	2012	UBC13 is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UEV1a or MMS2.	Lysine	75-78	ubiquitin conjugating enzyme E2 N	Homo sapiens	0-5
3190795-4	1988	These findings reflected main pharmacological action of MDP-Lys(L18), though there was some species difference.	Lysine	60-63	ribosomal protein L18	Mus musculus	64-67
24940800-6	2014	A conversion of lysines to arginines at positions 1114 and 1224 of the intracellular tail of murine nephrin led to decreased stability of nephrin, decreased expression at the plasma membrane, and decreased PI3K/AKT signaling.	Lysine	16-23	nephrosis 1, nephrin	Mus musculus	100-107
22679021-1	2012	UBC13 is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UEV1a or MMS2.	Lysine	75-78	ubiquitin conjugating enzyme E2 V1	Homo sapiens	127-132
24940800-6	2014	A conversion of lysines to arginines at positions 1114 and 1224 of the intracellular tail of murine nephrin led to decreased stability of nephrin, decreased expression at the plasma membrane, and decreased PI3K/AKT signaling.	Lysine	16-23	nephrosis 1, nephrin	Mus musculus	138-145
3190800-5	1988	Overall, the response to MDP-Lys(L18), in terms of the increase in number of WBCs, was good to excellent in 41.6% of patients.	Lysine	29-32	immunoglobulin kappa variable 1-13	Homo sapiens	33-36
3190802-2	1988	The chemical structure of MDP-Lys(L18) was confirmed by UV, IR, NMR and MS analyses as well as by elemental analysis.	Lysine	30-33	immunoglobulin kappa variable 1-13	Homo sapiens	34-37
22679021-1	2012	UBC13 is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UEV1a or MMS2.	Lysine	75-78	ubiquitin conjugating enzyme E2 V2	Homo sapiens	136-140
25369470-1	2014	Polycomb Repressive Complex 2 (PRC2) modulates the chromatin structure and transcriptional repression by trimethylation lysine 27 of histone H3 (H3K27me3), a process that necessitates the protein-protein interaction (PPI) between the catalytic subunit EZH2 and EED.	Lysine	120-126	embryonic ectoderm development	Homo sapiens	261-264
22679021-3	2012	A deubiquitinating enzyme OTUB1 suppresses Lys-63-linked ubiquitination of chromatin surrounding DSBs by binding UBC13 to inhibit its E2 activity independently of the isopeptidase activity.	Lysine	43-46	ubiquitin conjugating enzyme E2 N	Homo sapiens	113-118
2963831-5	1988	Promotion by plasmin was nullified by a subsequent treatment of the clot with carboxypeptidase B, indicating that the plasmin effect was related to the exposure of carboxy terminal lysine residues on fibrin.	Lysine	181-187	carboxypeptidase B1	Homo sapiens	78-96
25419660-0	2014	Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.	Lysine	29-35	mannose-binding lectin (protein C) 2	Mus musculus	78-99
25419660-4	2014	Furthermore, loss of the terminal glucose units on the derivatized lysine residues in mouse embryonic fibroblasts lacking the LH3 protein leads to defective disulphide bonding and oligomerization of rat MBL-A, with a decrease in the proportion of the larger functional MBL oligomers.	Lysine	67-73	mannose-binding lectin (protein A) 1	Mus musculus	203-208
25419660-4	2014	Furthermore, loss of the terminal glucose units on the derivatized lysine residues in mouse embryonic fibroblasts lacking the LH3 protein leads to defective disulphide bonding and oligomerization of rat MBL-A, with a decrease in the proportion of the larger functional MBL oligomers.	Lysine	67-73	mannose-binding lectin (protein C) 2	Mus musculus	203-206
22679021-4	2012	OTUB1 strongly suppresses UBC13-dependent Lys-63-linked tri-Ub production, whereas it allows di-Ub production in vitro.	Lysine	42-45	ubiquitin conjugating enzyme E2 N	Homo sapiens	26-31
22679021-10	2012	Finally, we propose a model for how capping of di-Ub by the OTUB1-UBC13-MMS2/UEV1a complex efficiently inhibits Lys-63-linked tri-Ub formation.	Lysine	112-115	ubiquitin conjugating enzyme E2 N	Homo sapiens	66-71
22679021-10	2012	Finally, we propose a model for how capping of di-Ub by the OTUB1-UBC13-MMS2/UEV1a complex efficiently inhibits Lys-63-linked tri-Ub formation.	Lysine	112-115	ubiquitin conjugating enzyme E2 V2	Homo sapiens	72-76
25391492-4	2014	We identify 954 SUMO3-modified lysine residues on 538 proteins and profile by quantitative proteomics the dynamic changes of protein SUMOylation following proteasome inhibition.	Lysine	31-37	small ubiquitin like modifier 3	Homo sapiens	16-21
22679021-10	2012	Finally, we propose a model for how capping of di-Ub by the OTUB1-UBC13-MMS2/UEV1a complex efficiently inhibits Lys-63-linked tri-Ub formation.	Lysine	112-115	ubiquitin conjugating enzyme E2 V1	Homo sapiens	77-82
25391492-7	2014	In contrast, a CDC73 K136R mutant translocates to the cytoplasm under the same conditions, further demonstrating the effectiveness of our method to characterize the dynamics of lysine SUMOylation.	Lysine	177-183	cell division cycle 73	Homo sapiens	15-20
22822152-5	2012	In mutants of ctns-1 (C. elegans homolog of CTNS), LAAT-1 was required to reduce lysosomal cystine levels and suppress lysosome enlargement by cysteamine, a drug that alleviates cystinosis by converting cystine to a lysine analog.	Lysine	216-222	Cystinosin homolog	Caenorhabditis elegans	14-20
24947179-3	2014	We previously reported loss of heterozygosity of the KDM6B gene, which encodes a histone demethylase for trimethylated histone H3 lysine 27, a repressive chromatin mark, in PDAC cells.	Lysine	130-136	lysine demethylase 6B	Homo sapiens	53-58
25127453-1	2014	BACKGROUND AND HYPOTHESIS: Pyridoxine dependent epilepsy (PDE) due to mutations in the ALDH7A1 gene (PDE-ALDH7A1) is caused by alpha-aminoadipic-semialdehyde-dehydrogenase enzyme deficiency in the lysine pathway resulting in the accumulation of alpha-aminoadipic acid semialdehyde (alpha-AASA).	Lysine	197-203	aldehyde dehydrogenase 7 family member A1	Homo sapiens	87-94
3384705-1	1988	A murine hybridoma was generated which secreted a monoclonal antibody (Mab) that specifically recognized the alpha 2(68)(E17)Asn----Lys beta 2 substitution of Hb G-Philadelphia.	Lysine	129-135	hemoglobin, beta adult minor chain	Mus musculus	136-142
25127453-1	2014	BACKGROUND AND HYPOTHESIS: Pyridoxine dependent epilepsy (PDE) due to mutations in the ALDH7A1 gene (PDE-ALDH7A1) is caused by alpha-aminoadipic-semialdehyde-dehydrogenase enzyme deficiency in the lysine pathway resulting in the accumulation of alpha-aminoadipic acid semialdehyde (alpha-AASA).	Lysine	197-203	aldehyde dehydrogenase 7 family member A1	Homo sapiens	105-112
22467858-8	2012	Nedd4-mediated ubiquitylation requires its binding to the C-terminal domain of Dvl1, comprising the DEP domain, and targets an N-terminal lysine-rich region upstream of the Dvl1 DIX domain.	Lysine	138-144	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5
25185627-1	2014	OBJECTIVES: The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin.	Lysine	131-137	elastin	Homo sapiens	170-182
25185627-1	2014	OBJECTIVES: The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin.	Lysine	131-137	elastin	Homo sapiens	175-182
3347046-8	1988	However, the effectiveness of several salts for the elution of GR was consistent in both resins as follows; MgCl2 = CaCl2 = Na2WO4 greater than (NH4)2SO4 = Na2MoO4 greater than arginine-HCl greater than lysine-HCl greater than KCI = NaCl.	Lysine	203-213	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	63-65
2472003-5	1988	The sequence shared by the otherwise unrelated DR1 and DR4 haplotypes from residue 67 in the DR a chain that appears to confer susceptibility is Leu-X-X-Gln-Arg/Lys.	Lysine	161-164	major histocompatibility complex, class II, DR beta 4	Homo sapiens	55-58
22763435-6	2012	This pathway involves the histone methylase SUV39H1, which participates in the trimethylation of histone H3 on lysine 9 (H3K9me3), a modification that provides binding sites for heterochromatin protein 1alpha (HP1alpha) and promotes transcriptional silencing.	Lysine	111-117	suppressor of variegation 3-9 1	Mus musculus	44-51
3124875-3	1987	Isolation of TPA was done by using a lysine-sepharose affinity chromatoculumn, then, TPA was measured by a fibrin plate method.	Lysine	37-43	chromosome 20 open reading frame 181	Homo sapiens	13-16
25132549-4	2014	Here we delineated the role of the histone 3 lysine 27 (H3K27) demethylases JMJD3 and UTX in T-ALL.	Lysine	45-51	lysine demethylase 6B	Homo sapiens	76-81
22763435-6	2012	This pathway involves the histone methylase SUV39H1, which participates in the trimethylation of histone H3 on lysine 9 (H3K9me3), a modification that provides binding sites for heterochromatin protein 1alpha (HP1alpha) and promotes transcriptional silencing.	Lysine	111-117	chromobox 5	Mus musculus	178-208
25193658-4	2014	Mutating several lysines of the gamma2IL into arginines makes the gamma2 subunit resistant to RNF34-induced degradation.	Lysine	17-24	ring finger protein 34	Rattus norvegicus	94-99
2442159-5	1987	The predicted amino acid composition of P-57 is rather unusual in that it is highly enriched in alanine, glutamic acid, and lysine residues, and relatively enriched with proline residues.	Lysine	124-130	coronin, actin binding protein 1A	Mus musculus	40-44
22763435-6	2012	This pathway involves the histone methylase SUV39H1, which participates in the trimethylation of histone H3 on lysine 9 (H3K9me3), a modification that provides binding sites for heterochromatin protein 1alpha (HP1alpha) and promotes transcriptional silencing.	Lysine	111-117	chromobox 5	Mus musculus	210-218
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	ring finger protein 8	Homo sapiens	50-54
25313689-5	2014	Specifically, positively charged Lys/Arg at position 322 and negatively charged Asp/Glu at position 440 occurred more frequently in CXCR4-using viruses, whereas negatively charged Asp/Glu at position 322 and positively charged Arg at position 440 occurred more frequently in R5 strains.	Lysine	33-36	C-X-C motif chemokine receptor 4	Homo sapiens	132-137
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	ubiquitin conjugating enzyme E2 N	Homo sapiens	109-114
24166499-3	2014	Here we report that merlin can be sumoylated on Lysine residue (K76) in vitro and in vivo.	Lysine	48-54	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	20-26
2888772-6	1987	Data are presented suggesting that matrix glycosaminoglycans (GAGs) prevent spontaneous tropoelastin aggregation in vivo, at least up to the deamination of lysine residues on tropoelastin by matrix lysyl oxidase.	Lysine	156-162	lysyl oxidase	Gallus gallus	198-211
24747049-5	2014	We propose that gene- and lysine-specific KDM4A/C-mediated control of histone methylation and thereby regulation of intrinsic factors and signaling factors such as BDNF provide a novel control mechanism of lineage decision.	Lysine	26-32	lysine demethylase 4A	Homo sapiens	42-47
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	ubiquitin conjugating enzyme E2 V2	Homo sapiens	115-119
24747049-5	2014	We propose that gene- and lysine-specific KDM4A/C-mediated control of histone methylation and thereby regulation of intrinsic factors and signaling factors such as BDNF provide a novel control mechanism of lineage decision.	Lysine	26-32	brain derived neurotrophic factor	Homo sapiens	164-168
22711821-5	2012	Mapping of translocation breakpoints using an acetylated histone H3 lysine 9 chromatin immunoprecipitation sequencing approach reveals Igh fusions up to ~350 kb upstream of Myc or the related oncogene Mycn.	Lysine	68-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	173-176
25135475-6	2014	Our subsequent analyses revealed that CTCF facilitates the stabilization of Polycomb repressive complex 2 (PRC2) and trimethylated lysine 27 of histone H3 (H3K27me3) at the human HOXA locus.	Lysine	131-137	CCCTC-binding factor	Homo sapiens	38-42
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Lysine	110-113	colony stimulating factor 2	Canis lupus familiaris	38-41
22820736-7	2012	Using a combination of tandem mass spectrometry and methyl-specific antibodies, we find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1.	Lysine	136-142	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	93-97
3624221-5	1987	The 1H and 13C nuclear magnetic resonance data indicated that imidazole C-2 of histidine is linked to C-6 of norleucine (epsilon-deaminated lysine residue) which in turn is linked to the C-6 amino group of hydroxylysine.	Lysine	140-146	complement C2	Bos taurus	72-75
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Lysine	135-138	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
25254379-5	2014	Interestingly, RNF26 promoted K11-linked polyubiquitination of MITA at lysine 150, a residue also targeted by RNF5 for K48-linked polyubiquitination.	Lysine	71-77	ring finger protein 26	Homo sapiens	15-20
25056949-2	2014	We have shown previously that, following TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a regulatory role in TNFR signaling.	Lysine	104-107	TNF receptor associated factor 2	Homo sapiens	132-164
25056949-2	2014	We have shown previously that, following TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF receptor-associated factor 2 (TRAF2), suggesting a regulatory role in TNFR signaling.	Lysine	104-107	TNF receptor associated factor 2	Homo sapiens	166-171
25056949-4	2014	This regulatory function toward JNK activation but not NF-kappaB activation depends on lysine 105 of TTP, which we identified as the corresponding TRAF2 ubiquitination site.	Lysine	87-93	TNF receptor associated factor 2	Homo sapiens	147-152
22406003-0	2012	Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation.	Lysine	40-46	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	13-17
3110158-0	1987	The bifunctional aminoadipic semialdehyde synthase in lysine degradation.	Lysine	54-60	aminoadipate-semialdehyde synthase	Homo sapiens	17-50
3110158-2	1987	The mammalian aminoadipic semialdehyde synthase is a bifunctional enzyme that catalyzes the first two sequential steps in lysine degradation in the major saccharopine pathway (Markovitz, P. J., Chuang, D. T., and Cox, R. P. (1984) J. Biol.	Lysine	122-128	aminoadipate-semialdehyde synthase	Homo sapiens	14-47
25189210-2	2014	Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3.2 T-type channel and modifies specific lysine residues in this region.	Lysine	227-233	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	183-189
22406003-3	2012	Phosphorylation and Lys(63)-linked polyubiquitination (polyUb) of TAK1 are critical for its activation.	Lysine	20-23	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	66-70
22406003-5	2012	Here we report that TNFalpha induces TAK1 Lys(48) linked polyubiquitination and degradation at the later time course.	Lysine	42-45	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	37-41
22406003-6	2012	Furthermore, we provide direct evidence that TAK1 is modified by Lys(48)-linked polyubiquitination at lysine-72 by mass spectrometry.	Lysine	65-68	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	45-49
3111739-1	1987	Aflatoxin B1 (AFB1) was shown to react primarily with one or more lysine residues in serum albumin (SA), accounting for more than half of the total binding to this protein.	Lysine	66-72	albumin	Rattus norvegicus	85-98
22406003-6	2012	Furthermore, we provide direct evidence that TAK1 is modified by Lys(48)-linked polyubiquitination at lysine-72 by mass spectrometry.	Lysine	102-108	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	45-49
25017124-1	2014	The lysyl oxidase (LOX) family is an emerging family of amine oxidases that is responsible for lysine-mediated crosslinks found in collagen and elastin.	Lysine	95-101	lysyl oxidase	Homo sapiens	4-17
25017124-1	2014	The lysyl oxidase (LOX) family is an emerging family of amine oxidases that is responsible for lysine-mediated crosslinks found in collagen and elastin.	Lysine	95-101	lysyl oxidase	Homo sapiens	19-22
22406003-7	2012	A K72R point mutation on TAK1 abolishes TAK1 Lys(48)-linked polyubiquitination and enhances TAK1/TAB1 co-overexpression-induced NF-kappaB activation.	Lysine	45-48	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	25-29
25017124-1	2014	The lysyl oxidase (LOX) family is an emerging family of amine oxidases that is responsible for lysine-mediated crosslinks found in collagen and elastin.	Lysine	95-101	elastin	Homo sapiens	144-151
22406003-7	2012	A K72R point mutation on TAK1 abolishes TAK1 Lys(48)-linked polyubiquitination and enhances TAK1/TAB1 co-overexpression-induced NF-kappaB activation.	Lysine	45-48	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	40-44
3105618-4	1987	Acidification or addition of lysine to plasma is also required for maximum immunoadsorption of plasma tPA antigen on anti-tPA-Ig-sepharose.	Lysine	29-35	chromosome 20 open reading frame 181	Homo sapiens	102-105
3105618-4	1987	Acidification or addition of lysine to plasma is also required for maximum immunoadsorption of plasma tPA antigen on anti-tPA-Ig-sepharose.	Lysine	29-35	chromosome 20 open reading frame 181	Homo sapiens	122-125
22406003-7	2012	A K72R point mutation on TAK1 abolishes TAK1 Lys(48)-linked polyubiquitination and enhances TAK1/TAB1 co-overexpression-induced NF-kappaB activation.	Lysine	45-48	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	40-44
24929439-10	2014	Boosting CARM1 activity by delivering cell-penetrating peptides of CARM1 not only recovered H3R17me2 but also restored adipogenesis evidenced by H3 acetylation at lysine 9, HDAC9 down-regulation, PPARgamma expression and triglyceride accumulation.	Lysine	163-169	coactivator associated arginine methyltransferase 1	Homo sapiens	9-14
24929439-10	2014	Boosting CARM1 activity by delivering cell-penetrating peptides of CARM1 not only recovered H3R17me2 but also restored adipogenesis evidenced by H3 acetylation at lysine 9, HDAC9 down-regulation, PPARgamma expression and triglyceride accumulation.	Lysine	163-169	coactivator associated arginine methyltransferase 1	Homo sapiens	67-72
22406003-8	2012	As expected, TAK1 K72R mutation inhibits TNFalpha-induced Lys(48)-linked TAK1 polyubiquitination and degradation.	Lysine	58-61	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	13-17
22406003-8	2012	As expected, TAK1 K72R mutation inhibits TNFalpha-induced Lys(48)-linked TAK1 polyubiquitination and degradation.	Lysine	58-61	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	73-77
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	47-50	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	84-88
25049231-0	2014	DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells.	Lysine	56-62	membrane associated ring-CH-type finger 8	Homo sapiens	39-42
22406003-10	2012	Our findings demonstrate that TNFalpha induces Lys(48)-linked polyubiquitination of TAK1 at lysine-72 and this polyubiquitination-mediated TAK1 degradation plays a critical role in the downregulation of TNFalpha-induced NF-kappaB activation.	Lysine	47-50	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	139-143
3106962-0	1987	Reaction of argininosuccinase with bromomesaconic acid: role of an essential lysine in the active site.	Lysine	77-83	argininosuccinate lyase	Homo sapiens	12-29
22504443-7	2012	Western blot analysis shows that intraperitoneal injection of NLC-CUR (100mg/kg) in mice induces a marked hypoacetylation of histone 4 (H4) at lysine 12 (K12) in the spinal cord compared with control group.	Lysine	143-149	H4 histone 16	Mus musculus	125-138
3105932-1	1987	The enzyme sequentially converts creatine kinase MM3 to MM2 and MM1 and hydrolyzes lysine and arginine from hippuryl-L-lysine and hippuryl-L-arginine.	Lysine	83-89	PNMA family member 2	Homo sapiens	56-59
24942738-7	2014	Although the Bul proteins mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiquitylation of the Lys-16 residue only.	Lysine	70-77	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	79-84
22562154-4	2012	Kap114 is sumoylated on lysine residue 909, which is part of a PsiKxD/E sumoylation consensus motif.	Lysine	24-30	Kap114p	Saccharomyces cerevisiae S288C	0-6
24936062-0	2014	F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).	Lysine	119-125	F-box protein 31	Homo sapiens	0-21
24936062-0	2014	F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).	Lysine	119-125	F-box protein 31	Homo sapiens	23-29
24936062-7	2014	Our results show that FBXO31 binds to MKK6 and mediates its Lys-48-linked polyubiquitination and degradation, thereby functioning as a negative regulator of MKK6-p38 signaling and protecting cells from stress-induced cell apoptosis.	Lysine	60-63	F-box protein 31	Homo sapiens	22-28
2887399-0	1987	Effects of lysine and glutamic acid or [corrected] Mg++ on the conformations of C3 and B, and the activation of the alternative complement pathway.	Lysine	11-17	complement C3	Homo sapiens	80-88
2887399-1	1987	The conversion of C3 and B in the mixture of C3, B, D and Mg++ ions was inhibited in the presence of arginine and lysine, but not in the presence of glutamic acid and aspartic acid among other amino acids.	Lysine	114-120	complement C3	Homo sapiens	18-26
22562154-5	2012	Kap114 containing a lysine-to-arginine point mutation at position 909 mislocalizes to the nucleus and is defective in promoting nuclear import.	Lysine	20-26	Kap114p	Saccharomyces cerevisiae S288C	0-6
24997987-5	2014	In addition, two amino acid substitutions in the extracellular domain of HLA-DQalpha1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60x10(-10)) and of HLA-DQbeta1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20x10(-9)) independently confer achalasia risk.	Lysine	102-108	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	73-76
24997987-5	2014	In addition, two amino acid substitutions in the extracellular domain of HLA-DQalpha1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60x10(-10)) and of HLA-DQbeta1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20x10(-9)) independently confer achalasia risk.	Lysine	102-108	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	120-123
2948613-5	1986	Furthermore, the active isomer of LY-141865, LY-171555 at 0.1 to 50 nM, also decreased the release of CCK-LI from the tissue slices, while the inactive isomer, LY-181990 at 1 nM, did not affect CCK-LI release.	Lysine	34-36	cholecystokinin	Rattus norvegicus	102-105
22493438-4	2012	In the present study, we report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins.	Lysine	123-126	signal transducing adaptor molecule 2	Homo sapiens	92-97
2948613-5	1986	Furthermore, the active isomer of LY-141865, LY-171555 at 0.1 to 50 nM, also decreased the release of CCK-LI from the tissue slices, while the inactive isomer, LY-181990 at 1 nM, did not affect CCK-LI release.	Lysine	34-36	cholecystokinin	Rattus norvegicus	194-197
2948613-5	1986	Furthermore, the active isomer of LY-141865, LY-171555 at 0.1 to 50 nM, also decreased the release of CCK-LI from the tissue slices, while the inactive isomer, LY-181990 at 1 nM, did not affect CCK-LI release.	Lysine	45-47	cholecystokinin	Rattus norvegicus	102-105
2948613-5	1986	Furthermore, the active isomer of LY-141865, LY-171555 at 0.1 to 50 nM, also decreased the release of CCK-LI from the tissue slices, while the inactive isomer, LY-181990 at 1 nM, did not affect CCK-LI release.	Lysine	45-47	cholecystokinin	Rattus norvegicus	102-105
24997987-5	2014	In addition, two amino acid substitutions in the extracellular domain of HLA-DQalpha1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60x10(-10)) and of HLA-DQbeta1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20x10(-9)) independently confer achalasia risk.	Lysine	102-108	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	212-220
24997987-5	2014	In addition, two amino acid substitutions in the extracellular domain of HLA-DQalpha1 at position 41 (lysine encoded by HLA-DQA1*01:03; P=5.60x10(-10)) and of HLA-DQbeta1 at position 45 (glutamic acid encoded by HLA-DQB1*03:01 and HLA-DQB1*03:04; P=1.20x10(-9)) independently confer achalasia risk.	Lysine	102-108	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	231-239
25143281-2	2014	To elucidate the different roles and importance of H3K4 and H3K36 modifications in expression of inducible genes such as Cal1, SSA3, PHO5 and the growth of yeast cell, we constructed three different yeast mutant strains carrying mutations of lysine 4, 36, or both to leucine in the histone H3 tail.	Lysine	242-248	chitin synthase CHS3	Saccharomyces cerevisiae S288C	121-125
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Lysine	79-82	insulin like growth factor 1 receptor	Homo sapiens	123-137
24981175-5	2014	Mice fed a lysine-deficient diet for 2 days show decreased Akt activity, TKT activity, and purine synthesis in multiple organs.	Lysine	11-17	transketolase	Mus musculus	73-76
22493438-4	2012	In the present study, we report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins.	Lysine	136-139	signal transducing adaptor molecule 2	Homo sapiens	92-97
22467880-5	2012	We report that the SUMO-interacting motif 1 (SIM1) and the C-box of hPc2 are critical regions required for ZNF131 SUMOylation and define the ZNF131 SUMOylation site as lysine 567.	Lysine	168-174	chromobox 4	Homo sapiens	68-72
24952432-1	2014	JMJD2C is a candidate oncogene that encodes a histone lysine demethylase with the ability to demethylate the lysine 9 residue of histone H3 (H3K9).	Lysine	54-60	lysine demethylase 4C	Homo sapiens	0-6
22467880-5	2012	We report that the SUMO-interacting motif 1 (SIM1) and the C-box of hPc2 are critical regions required for ZNF131 SUMOylation and define the ZNF131 SUMOylation site as lysine 567.	Lysine	168-174	zinc finger protein 131	Homo sapiens	141-147
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	TNF receptor associated factor 6	Homo sapiens	11-16
25606432-4	2014	L23a is highly basic, containing a combined 45 Arg, Lys, and His residues and only 14 Asp and Glu residues.	Lysine	52-55	ribosomal protein L23a	Homo sapiens	0-4
24744315-1	2014	Lysine-specific demethylase (LSD) 1 is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3, thereby mediating gene repression.	Lysine	117-123	lysine demethylase 1A	Homo sapiens	0-35
24744315-2	2014	Here we tested the hypothesis that riboflavin deficiency causes a loss of LSD1 activity in HepG2 human hepatocarcinoma cells, leading to an accumulation of lysine-4-dimethylated histone H3 (H3K4me2) marks in the albumin promoter and aberrant upregulation of albumin expression.	Lysine	156-162	lysine demethylase 1A	Homo sapiens	74-78
3015965-6	1986	The 9,700-Da fragment is N-terminal in CRP and probably terminates at Lys-89.	Lysine	70-73	catabolite gene activator protein	Escherichia coli	39-42
3015965-8	1986	The 6,000-Da fragment extends from Val-131 to Arg-185 or Lys-188 and contains part of the F helix involved in DNA binding by CRP.	Lysine	57-60	catabolite gene activator protein	Escherichia coli	125-128
2871191-9	1986	The other MTX analogues and the previously reported lysine derivative (mAPA-Lys) showed DHFR affinity similar to that of mAPA-Orn but lacked activity as FPGS inhibitors.	Lysine	52-58	dihydrofolate reductase	Mus musculus	88-92
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	TNF receptor associated factor 6	Homo sapiens	34-39
24779776-4	2014	Tri-methylation of lysine 4 on histone H3 (H3K4) enhanced at the promoter of HSP104, PRO1, TPS1 and SOD1 in ethanol-tolerant variants of S. cerevisiae was also diminished after tenth passage in stress-free cultures.	Lysine	19-25	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	91-95
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	TNF receptor associated factor 6	Homo sapiens	34-39
2869571-1	1986	The activity of lysyl oxidase, the cross-linking enzyme of elastin and collagen, was measured in culture media of human skin fibroblasts, human aortic medial smooth muscle cells (SMCs) and adventitial fibroblasts using [3H]lysine-labelled elastin substrate.	Lysine	223-229	lysyl oxidase	Homo sapiens	16-29
22301686-1	2012	AIMS: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver.	Lysine	115-121	BCL2 associated X, apoptosis regulator	Rattus norvegicus	257-260
3878862-1	1985	Polyriboinosinic-polycytidylic acid with poly-L-lysine stabilized with carboxymethylcellulose [poly(I,C)-LC] augmented, in a dose- and time-dependent manner, secretion of colony-stimulating factor (CSF) by peritoneal macrophages (M phi) and bone marrow cells (BMC).	Lysine	41-54	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	171-196
25070639-2	2014	In this study, using a floral stem cell model in Arabidopsis thaliana, we uncovered a role for TOPOISOMERASE1alpha (TOP1alpha) in Polycomb Group (PcG) protein-mediated histone 3 lysine 27 trimethylation (H3K27me3) at, and transcriptional repression of, the stem cell maintenance gene WUSCHEL (WUS).	Lysine	178-184	DNA topoisomerase I alpha	Arabidopsis thaliana	116-125
24971881-2	2014	We report that both small ubiquitin-like modifier (SUMO) 1 and SUMO2/3 modify ALS-linked SOD1 mutant proteins at lysine 75 in a motoneuronal cell line, the cell type affected in ALS.	Lysine	113-119	small ubiquitin like modifier 2	Homo sapiens	63-70
3878862-1	1985	Polyriboinosinic-polycytidylic acid with poly-L-lysine stabilized with carboxymethylcellulose [poly(I,C)-LC] augmented, in a dose- and time-dependent manner, secretion of colony-stimulating factor (CSF) by peritoneal macrophages (M phi) and bone marrow cells (BMC).	Lysine	41-54	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	198-201
22357272-4	2012	Here, we found the epigenetic modification of the BZLF1 promoter in latent Raji cells by histone H3 lysine 27 trimethylation (H3K27me3), H3K9me2/me3, and H4K20me3.	Lysine	100-106	protein Zta	Human gammaherpesvirus 4	50-55
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Lysine	85-88	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	106-109
24927542-2	2014	Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 with histone H3 methylated on lysine 9 (H3K9me3).	Lysine	110-116	lysine acetyltransferase 5	Homo sapiens	18-23
24927542-2	2014	Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 with histone H3 methylated on lysine 9 (H3K9me3).	Lysine	110-116	lysine acetyltransferase 5	Homo sapiens	74-79
22378382-2	2012	FLC activation by FRI is accompanied by an increase in specific histone modifications, such as tri-methylation of histone H3 at lysine 4 (H3K4me3), and requires three H3K4 methyltransferases, the Drosophila Trithorax-class Arabidopsis trithorax1 (ATX1) and ATX2, and yeast Set1-class ATX-related7/set domain group25 (ATXR7/SDG25).	Lysine	128-134	FRIGIDA-like protein	Arabidopsis thaliana	18-21
24727527-2	2014	Results revealed that (a) a positively charged amino acid, lysine (K) or arginine (R), in TBP can anchor ferritin to negative zeta-potential substrates, (b) the adsorption force of K is stronger than R, and (c) local electrostatic interactions and flexibility of TBP directly affect adsorption.	Lysine	59-65	TATA-box binding protein	Homo sapiens	90-93
24727527-2	2014	Results revealed that (a) a positively charged amino acid, lysine (K) or arginine (R), in TBP can anchor ferritin to negative zeta-potential substrates, (b) the adsorption force of K is stronger than R, and (c) local electrostatic interactions and flexibility of TBP directly affect adsorption.	Lysine	59-65	TATA-box binding protein	Homo sapiens	263-266
3929832-2	1985	Modification of positive lysine residues with negative or neutral groups (citraconic anhydride and diketene, respectively) resulted, for extensively reacted complexes (90%), in structural alterations and in a marked decrease in reactivity with purified human lecithin:cholesterol acyltransferase.	Lysine	25-31	lecithin-cholesterol acyltransferase	Homo sapiens	259-295
22522173-4	2012	Here we show that Kdm2b, a histone H3 Lys 36 dimethyl (H3K36me2)-specific demethylase, has the capacity to promote iPSC generation.	Lysine	38-41	lysine demethylase 2B	Homo sapiens	18-23
3928261-5	1985	The gene-enzyme relationships have been determined for ten of the lysine loci which include two unlinked gene functions required for each of AA reductase (LYS2 and LYS5) and Saccharopine reductase (LYS9 and LYS14).	Lysine	66-72	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	198-202
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	lysine demethylase 1A	Homo sapiens	102-106
24782528-6	2014	ASH2L is a core subunit of KMT2 methyltransferase complexes that target histone H3 lysine 4 (H3K4), a mark associated with open chromatin.	Lysine	83-89	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	0-5
22483804-2	2012	In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1-MLL4) whose specific functions are largely unknown.	Lysine	30-36	lysine methyltransferase 2A	Homo sapiens	175-179
24808134-6	2014	For one APOL1 kidney risk variant, a two-residue deletion of amino acids 388 and 389 causes a shift in a single lysine residue that mimics the Old World monkey sequence, which augments trypanolytic activity by preventing SRA binding.	Lysine	112-118	steroid receptor RNA activator 1	Homo sapiens	221-224
3938982-3	1985	Mature EGF was released by lysine specific proteolysis of a fusion protein consisting of part of the E. coli TrpE protein, a lysine linker and EGF polypeptide.	Lysine	125-131	EGF	Ovis aries	7-10
22318730-1	2012	Heterochromatin protein 1 (HP1) proteins are "gatekeepers" of epigenetic gene silencing that is mediated by lysine 9 of histone H3 methylation (H3K9me).	Lysine	108-114	chromobox 5	Homo sapiens	27-30
3885009-6	1985	The rad3-1 mutation changed a glutamic acid to lysine, and the rad3-2 mutation changed a glycine to arginine.	Lysine	47-53	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	4-8
6424960-4	1984	The carboxy terminal amino acid of human, canine, and rabbit tissue MM3 was determined to be lysine, a specific substrate for carboxypeptidases N and B. Evidently the mechanism for the production of multiple forms of creatine MM in human plasma is the hydrolysis of a positively charged C-terminal lysine residue from one M subunit (MM2), followed by hydrolysis of the C-terminal lysine from the other subunit (MM1).	Lysine	93-99	PNMA family member 2	Homo sapiens	333-336
24583231-9	2014	Here we confirm that mutating the putatively sumoylated lysine (K10) of the Rhesus macaque TRIM5alpha (TRIM5alphaRh) to an arginine has only a small effect on restriction.	Lysine	56-62	tripartite motif containing 5	Macaca mulatta	91-101
24583231-16	2014	In addition, lysine 10 regulates TRIM5alpha nuclear shuttling and nuclear localization, which may also be related to its role in innate immunity activation.	Lysine	13-19	tripartite motif containing 5	Macaca mulatta	33-43
22387026-0	2012	Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.	Lysine	11-17	proliferating cell nuclear antigen	Homo sapiens	88-92
6326126-5	1984	Spt2 and spt3 mutations, known to suppress Ty insertions and their solo delta derivatives at HIS4, can also suppress at least one of the Ty insertions (Ty61) at LYS2 and can also suppress the Lys- phenotype of a solo delta derivative of another Ty insertion (Ty128) at LYS2.	Lysine	192-195	transcriptional regulator SPT3	Saccharomyces cerevisiae S288C	9-13
22500771-3	2012	In the recent solution NMR structure of the DAP12-NKG2C immunoreceptor transmembrane helix complex, five functionally required interfacial residues (two Asps and two Thrs in the DAP12 dimer and one Lys in NKG2C) display a surprising arrangement in which one Asp side chain faces the membrane hydrophobic core.	Lysine	198-201	transmembrane immune signaling adaptor TYROBP	Homo sapiens	44-49
6696761-2	1984	The carboxy-terminal region of the protein was identified by carboxypeptidase digestion: the sequence -Lys-Leu-COOH was found instead of the reported -Gly-COOH, thus showing identity with the carboxy-terminal sequence of glucose-6-phosphate dehydrogenase from human leukocytes and platelets.	Lysine	103-106	glucose-6-phosphate dehydrogenase	Homo sapiens	221-254
24627472-2	2014	The protein RAP80 plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains.	Lysine	155-158	ubiquitin interaction motif containing 1	Homo sapiens	12-17
24627472-2	2014	The protein RAP80 plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains.	Lysine	155-158	BRCA1 DNA repair associated	Homo sapiens	75-80
24627472-2	2014	The protein RAP80 plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains.	Lysine	155-158	BRCA2 DNA repair associated	Homo sapiens	81-86
24692429-6	2014	Thus, in addition to sulfur amino acid catabolism, ETHE1 also affects the oxidation of branched-chain amino acids and lysine.	Lysine	118-124	glyoxalase II 3	Arabidopsis thaliana	51-56
6332065-3	1984	Reverse-phase high pressure liquid chromatographic analysis of tryptic peptides labeled with 3H-arginine and 3H-lysine revealed that A28*, A28, and A2 share approximately 65% of their tryptic peptides.	Lysine	109-118	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	133-136
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Lysine	23-29	serpin family E member 1	Homo sapiens	217-222
6688942-3	1983	The proposed sequence reveals a high content of basic amino acids (Arg and Lys) and Leu, is consistent with the amino acid composition, and predicts the correct number of peptides derived from tryptic digests reported for ligandin.	Lysine	75-78	glutathione S-transferase alpha 2	Rattus norvegicus	222-230
6554235-2	1983	Polymeric polycations alone, whether natural or synthetic, prevented formation of the cell-bound amplification convertase and of the fluid-phase interaction of C3b, B and D, in a dose-related fashion in the concentration range of 1 to 2 X 10(-8)M for poly-L-lysine (PLL) 50,000.	Lysine	251-264	complement C3	Homo sapiens	160-172
24782567-4	2014	We developed a method that enabled proteome-wide identification of sumoylated lysines that involves the expression of polyhistidine (6His)-tagged SUMO2 with Thr(90) mutated to Lys.	Lysine	78-85	small ubiquitin like modifier 2	Homo sapiens	146-151
24782567-5	2014	Endoproteinase cleavage with Lys-C of 6His-SUMO2(T90K)-modified proteins from human cell lysates produced a diGly remnant on SUMO2(T90K)-conjugated lysines, enabling immunoprecipitation of SUMO2(T90K)-modified peptides and producing a unique mass-to-charge signature.	Lysine	148-155	small ubiquitin like modifier 2	Homo sapiens	43-48
24782567-5	2014	Endoproteinase cleavage with Lys-C of 6His-SUMO2(T90K)-modified proteins from human cell lysates produced a diGly remnant on SUMO2(T90K)-conjugated lysines, enabling immunoprecipitation of SUMO2(T90K)-modified peptides and producing a unique mass-to-charge signature.	Lysine	148-155	small ubiquitin like modifier 2	Homo sapiens	125-130
24782567-5	2014	Endoproteinase cleavage with Lys-C of 6His-SUMO2(T90K)-modified proteins from human cell lysates produced a diGly remnant on SUMO2(T90K)-conjugated lysines, enabling immunoprecipitation of SUMO2(T90K)-modified peptides and producing a unique mass-to-charge signature.	Lysine	148-155	small ubiquitin like modifier 2	Homo sapiens	125-130
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Lysine	23-29	serpin family E member 1	Homo sapiens	224-257
22095636-7	2012	HuR is stabilized by Mdm2-mediated NEDDylation in at least three lysine residues, ensuring its nuclear localization and protection from degradation.	Lysine	65-71	ELAV like RNA binding protein 1	Homo sapiens	0-3
24777122-4	2014	Molecular biological analysis revealed that lz/RUNXs are sumoylated by dPias/PIAS1 at an evolutionarily conserved lysine residue (K372 of lz, K144 of RUNX1, K181 of RUNX2 and K148 of RUNX3).	Lysine	114-120	runt related transcription factor 3	Mus musculus	183-188
22290431-8	2012	Finally, our results also identify lysine 63-linked autoubiquitination of TRAF6 as a process essential for its regulatory role in starvation-induced muscle atrophy.	Lysine	35-41	TNF receptor associated factor 6	Homo sapiens	74-79
24742347-9	2014	ISG activation depends on Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters and a single exon Tat protein more strongly modulated the luciferase activity mediated by MAP2K3, MAP2K6, and IRF7 promoter sequences located 5" of the RNA start site than the wild type two-exon Tat, while a cysteine and lysine Tat mutants, reduced in LTR transactivation, had negligible effects on these promoters.	Lysine	303-309	mitogen-activated protein kinase kinase 3	Homo sapiens	172-178
6236789-2	1983	Plasmin(ogen) contains structures, called lysine-binding sites, which mediate its interaction with fibrin and with alpha 2-antiplasmin.	Lysine	42-48	serpin family F member 2	Homo sapiens	115-134
22354625-3	2012	The most common mutation associated with MERRF syndrome, m.8344A &gt; G in the gene MT-TK, which encodes transfer RNA(Lysine), affects the translation of all mitochondrial DNA encoded proteins.	Lysine	118-124	mitochondrially encoded tRNA lysine	Homo sapiens	84-89
6414065-6	1983	Insulin caused a fall in intracellular lysine concentration in skeletal muscle and in plasma, which suggests that the hormone can reduce muscle protein catabolism in the fetal lamb in the last trimester of gestation.	Lysine	39-45	LOC105613195	Ovis aries	0-7
24706898-3	2014	MEX3C colocalizes with RIG-I in the stress granules of virally infected cells, and its overexpression causes the lysine-63-linked ubiquitination of RIG-I and activates IFN-beta promoter.	Lysine	113-119	DEAD/H box helicase 58	Mus musculus	148-153
24706898-3	2014	MEX3C colocalizes with RIG-I in the stress granules of virally infected cells, and its overexpression causes the lysine-63-linked ubiquitination of RIG-I and activates IFN-beta promoter.	Lysine	113-119	interferon beta 1, fibroblast	Mus musculus	168-176
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	36-39	inhibitor of growth family member 4	Homo sapiens	0-4
22235122-6	2012	We found that the C-terminal 16-amino acid fragment of Rad27, a highly polybasic region due to the presence of multiple positively charged lysine and arginine residues, was sufficient and necessary for the stimulation of both Rad27 and Dna2.	Lysine	139-145	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	55-60
23624912-4	2014	ING4 bound to p65 and delivered the Lys-48-linked polyubiquitin to Lys-62 residue of p65, leading to ubiquitination of p65 and degradation.	Lysine	67-70	inhibitor of growth family member 4	Homo sapiens	0-4
23624912-5	2014	Lys-62 residue of p65 was required for ING4-mediated ubiquitination of p65 and degradation.	Lysine	0-3	inhibitor of growth family member 4	Homo sapiens	39-43
6852239-1	1983	The amino acid sequence of a newly isolated pentapeptide, neo-kyotorphin from bovine brain was synthetically verified to be Thr-Ser-Lys-Tyr-Arg corresponding to the C-terminal portion of hemoglobin alpha-chain.	Lysine	132-135	hemoglobin subunit alpha	Bos taurus	187-209
22221880-6	2012	One mutant bore an intriguing Dicer1 allele in which a conserved glutamic acid in the RNase IIIa domain was substituted with a lysine.	Lysine	127-133	dicer 1, ribonuclease III	Homo sapiens	30-36
6687626-7	1983	As is the case for the bovine arginine-vasopressin-neurophysin II (AVP-NpII) precursor, the signal sequence of the OT-NpI precursor is immediately followed by the nonapeptide hormone which is connected to neurophysin I by a Gly-Lys-Arg sequence.	Lysine	228-231	arginine vasopressin	Bos taurus	30-65
6687626-7	1983	As is the case for the bovine arginine-vasopressin-neurophysin II (AVP-NpII) precursor, the signal sequence of the OT-NpI precursor is immediately followed by the nonapeptide hormone which is connected to neurophysin I by a Gly-Lys-Arg sequence.	Lysine	228-231	arginine vasopressin	Bos taurus	67-75
6401433-3	1983	Approximately 30,000 sites/cell belonged to the high-affinity class with a Kd of about 3 x 10(-8) M. Modification of two lysine residues of thrombin with pyridoxal 5"-phosphate (PLP2-thrombin) destroyed the high-affinity binding and about three-fourths of the low-affinity bindings.	Lysine	121-127	proteolipid protein 2	Homo sapiens	178-182
24717514-10	2014	NNMT inhibition increases adipose SAM and NAD(+) levels and upregulates ODC and SSAT activity as well as expression, owing to the effects of NNMT on histone H3 lysine 4 methylation in adipose tissue.	Lysine	160-166	nicotinamide N-methyltransferase	Mus musculus	0-4
24717514-10	2014	NNMT inhibition increases adipose SAM and NAD(+) levels and upregulates ODC and SSAT activity as well as expression, owing to the effects of NNMT on histone H3 lysine 4 methylation in adipose tissue.	Lysine	160-166	ornithine decarboxylase, structural 1	Mus musculus	72-75
24717514-10	2014	NNMT inhibition increases adipose SAM and NAD(+) levels and upregulates ODC and SSAT activity as well as expression, owing to the effects of NNMT on histone H3 lysine 4 methylation in adipose tissue.	Lysine	160-166	nicotinamide N-methyltransferase	Mus musculus	141-145
24550393-9	2014	Furthermore, the sequence of cross-linking domains has a dramatic effect on self-assembly properties of elastin-like polypeptides, and the presence of lysine residues in these domains may serve to prevent inappropriate ordered aggregation.	Lysine	151-157	elastin	Homo sapiens	104-111
22242964-3	2012	The simulations show that while the wild-type SET7/9 is a monomethylase, the Y245 A mutation increases the ability of the enzyme to add more methyl groups on the target lysine (i.e., acting as a trimethylase).	Lysine	169-175	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	46-52
24486797-6	2014	LSD1 is a FAD-dependent amine oxidase and promotes demethylation of lysine 4 and lysine 9 of mono- and di-methylated histone H3.	Lysine	68-74	lysine demethylase 1A	Homo sapiens	0-4
24486797-6	2014	LSD1 is a FAD-dependent amine oxidase and promotes demethylation of lysine 4 and lysine 9 of mono- and di-methylated histone H3.	Lysine	81-87	lysine demethylase 1A	Homo sapiens	0-4
22868801-8	2012	Nepsilon-Hcy-Lys levels correlated with PON1 (r=-0.62, p&lt;0.0001), ADMA (r=0.58, p&lt;0.0001) and PAI-1 (r=0.59, p&lt;0.0001).	Lysine	13-16	serpin family E member 1	Homo sapiens	100-105
6226585-2	1983	This correlation, and the large body of (largely) circumstantial but still quite convincing data, suggests that these Ly and Leu molecules play a very important role in T cell responses by actually interacting with monomorphic MHC class specific determinants.	Lysine	118-120	major histocompatibility complex, class I, C	Homo sapiens	227-230
22105069-3	2012	To more thoroughly characterize the vinylogous urea binding site, horizontal alanine scanning mutagenesis between p51 residues Lys-275 and Thr-286 (comprising alpha-helix I and portions of the neighboring alphaH/alphaI and alphaI/alphaJ connecting loops) was combined with a limited vertical scan of Cys-280.	Lysine	127-130	tumor protein p63	Homo sapiens	114-117
6342072-1	1983	Eleven isoaccepting lysine tRNAs from mammalian sources are demonstrable by RPC-5 chromatography and polyacrylamide gel electrophoresis.	Lysine	20-26	RNA polymerase III subunit E	Homo sapiens	76-81
24391131-5	2014	Lys 63-linked ubiquitination of upstream proteins in the cascade (cIAP1/2 and TRAF6), mandatory for TRAF3 degradation, was also reduced postinfection.	Lysine	0-3	TNF receptor-associated factor 3	Mus musculus	100-105
24397908-8	2014	SIRT1 expression correlated with that of histone H3 lysine 9 acetylation (H3K9ac) and methylation (H3K9me2).	Lysine	52-58	sirtuin 1	Homo sapiens	0-5
21740187-2	2012	For XPD Lys751Gln polymorphism, an increased risk of bladder cancer was found to be associated with the Gln variant allele (odds ratio [OR]=1.86, 95% confidence interval [CI]=1.27-2.73), on taking AA (Lys/Lys) as the referent genotype.	Lysine	8-11	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
24478033-7	2014	Treatment with carboxypeptidase B to assess the roles of carboxyl-terminal lysines in cellular receptors leads in most cases to decreases in plasminogen activation as well as plasminogen and apo(a) binding; however, inhibition of plasminogen activation by apo(a) was unaffected.	Lysine	75-82	carboxypeptidase B1	Homo sapiens	15-33
6216400-3	1982	Electrophoretic analysis of DNA fragments generated by DNAse I reveals a "nucleodisome" structure of chromatin not only is condensed inactive nuclei of mature erythrocytes but also in chromatin of transcriptionally-active cells possessing a usual lysine-rich histone H1 such as rat thymus cells or CHO cell line.	Lysine	247-253	deoxyribonuclease 1	Rattus norvegicus	55-62
21740187-2	2012	For XPD Lys751Gln polymorphism, an increased risk of bladder cancer was found to be associated with the Gln variant allele (odds ratio [OR]=1.86, 95% confidence interval [CI]=1.27-2.73), on taking AA (Lys/Lys) as the referent genotype.	Lysine	201-204	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	4-7
7104383-8	1982	The change in elastin concentration was accompanied by high hydroxyproline/proline or hydroxylysine/lysine ratios which indicates that the proteins of the aneurysmatic aortic wall contained more collagen than the proteins of the control aortic wall.	Lysine	93-99	elastin	Homo sapiens	14-21
24523286-7	2014	We also found that spartin, via the UBR, binds Lys-63-linked ubiquitin chains but does not bind Lys-48-linked ubiquitin chains.	Lysine	47-50	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	Mus musculus	19-26
22052239-7	2012	Two out of 86 cases revealed a 130th codon G&gt;A missense mutation in exon 8 of PTEN which resulted in an Arg change to Gln in the PTEN protein structure; and a 334th codon A&gt;T missense mutation in exon 8 of PTEN, which resulted in an Asn change to Lys in the PTEN protein structure.	Lysine	253-256	phosphatase and tensin homolog	Homo sapiens	81-85
27896080-0	2014	Lysine-restricted diet and mild cerebral serotonin deficiency in a patient with pyridoxine-dependent epilepsy caused by ALDH7A1 genetic defect.	Lysine	0-6	aldehyde dehydrogenase 7 family member A1	Homo sapiens	120-127
6273432-1	1982	Amidination of the available lysine residues of the complex between RNase A and human placental RNase inhibitor has been performed with methyl acetimidate; the conditions of the derivatization preserve the complex functionally intact.	Lysine	29-35	ribonuclease/angiogenin inhibitor 1	Homo sapiens	86-111
22227192-5	2012	Mutation of two lysine (K) residues in its GK motif to either arginine (R) or glutamine (Q) blocked SPK1 ubiquitination and prevented its degradation by the proteasome.	Lysine	16-22	sphingosine kinase 1	Homo sapiens	100-104
6761347-7	1982	Pyridoxal 5"-phosphate, a specific probe for lysine residues, exerts dual effects on glucocorticoid-receptor complexes, since it stimulates the rate of activation and also inhibits the binding of previously activated complexes to nuclei or DNA-cellulose.	Lysine	45-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	85-108
24607280-3	2014	Here, we show the antagonistic role of Set2 methyltransferase, which is specific for histone H3 at lysine 36, in regulating telomeric silencing and cellular lifespan.	Lysine	99-105	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	39-43
23604120-1	2014	The sirtuins (SIRT 1-7) comprise a family of NAD+-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation.	Lysine	105-111	sirtuin 1	Homo sapiens	14-22
22227192-6	2012	The processes of acetylation and ubiquitination may compete for the same lysine residues and, therefore, form a switch for SPK1 protein regulation.	Lysine	73-79	sphingosine kinase 1	Homo sapiens	123-127
22081111-5	2012	Contrary to in-vitro assays that lead to spurious modification of several lysine residues of Rpn10 (regulatory proteasomal non-ATPase subunit), the reconstituted system faithfully recapitulates its monoubiquitylation on lysine 84 that is observed in vivo.	Lysine	74-80	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	93-98
24647965-4	2014	We observe that Parkin efficiently ubiquitylates Miro1 at highly conserved lysine residues, 153, 230, 235, 330 and 572, upon phosphorylation by PINK1.	Lysine	75-81	PTEN induced kinase 1	Homo sapiens	144-149
24594605-7	2014	Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice.	Lysine	18-24	glutamate receptor, ionotropic, kainate 2 (beta 2)	Mus musculus	133-138
23508577-3	2014	The dynamic process of histone methylation is the latest of these epigenetic modifications to be described, and the identification and characterization of LSD1 as a demethylase of lysine 4 of histone H3 (H3K4) has confirmed that both the enzyme and the modified histone play important roles as regulators of gene expression.	Lysine	180-186	lysine demethylase 1A	Homo sapiens	155-159
7326238-17	1981	In certain cases, the small molecules bind to C3b via ester linkages (e.g., glucose); in others, the bond is an amide linkage (e.g., lysine).	Lysine	133-139	complement C3	Homo sapiens	46-49
7287747-3	1981	The charge heterogeneity of the various species arises from the removal, by a carboxypeptidase B-like enzyme in the submaxillary gland, of this lysine residue and/or the original COOH-terminal arginine residue of the shorter Mr = 10,000 chain.	Lysine	144-150	carboxypeptidase B1	Homo sapiens	78-96
22081111-5	2012	Contrary to in-vitro assays that lead to spurious modification of several lysine residues of Rpn10 (regulatory proteasomal non-ATPase subunit), the reconstituted system faithfully recapitulates its monoubiquitylation on lysine 84 that is observed in vivo.	Lysine	220-226	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	93-98
22128170-3	2012	Here, we show that Amer2 recruits APC to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate lipids via lysine-rich motifs and that APC links beta-catenin and the destruction complex components axin and conductin to Amer2.	Lysine	124-130	APC membrane recruitment protein 2 S homeolog	Xenopus laevis	19-24
6260796-1	1981	Cytochrome c derivatives modified with a photoactivatable arylazido group in selected lysine residues were irradiated in the presence of cytochrome c peroxidase (EC 1.11.1.5).	Lysine	86-92	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	137-160
24452550-1	2014	The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16.	Lysine	209-215	lysine acetyltransferase 5	Homo sapiens	89-94
22178397-6	2012	Upon heat shock, HSF triggers these PARP activities mechanistically by directing Tip60 acetylation of histone H2A lysine 5 at the 5" end of Hsp70, where inactive PARP resides before heat shock.	Lysine	114-120	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	36-40
24369422-2	2014	Here, we show that L3MBTL2 is modified by SUMO2/3 at lysine residues 675 and 700 close to the C-terminus.	Lysine	53-59	small ubiquitin like modifier 2	Homo sapiens	42-47
7345564-3	1981	The isolation of TR-c from a crude bacterial sonicate involves five fractionation steps: anion exchange chromatography (DE-52 Whatman), gel filtration (Ac-A-22, Ultrogel), and affinity chromatography respectively on phenyl-Sepharose CL 4B, iminodiacetic acid-Sepharose CL 4B, and lysine-Sepharose 4B.	Lysine	280-286	tRNA-Cys (GCA) 24-1	Homo sapiens	17-21
22110129-5	2012	Here we show that deletion of Jarid2 results in reduced methylation of lysine 9 on histone H3 (H3K9) at the Notch1 genomic locus in embryonic hearts.	Lysine	71-77	notch 1	Mus musculus	108-114
6458449-0	1981	Guanidination of the lysine residues present in fibrous elastin and in soluble elastin peptides.	Lysine	21-27	elastin	Homo sapiens	56-63
6458449-0	1981	Guanidination of the lysine residues present in fibrous elastin and in soluble elastin peptides.	Lysine	21-27	elastin	Homo sapiens	79-86
6458449-1	1981	We have found that only 20 to 30% of the lysine residues measured after acid hydrolysis of insoluble elastin and alpha-elastin were blocked by prior guanidination of elastin with o-methylisourea.	Lysine	41-47	elastin	Homo sapiens	101-108
6458449-1	1981	We have found that only 20 to 30% of the lysine residues measured after acid hydrolysis of insoluble elastin and alpha-elastin were blocked by prior guanidination of elastin with o-methylisourea.	Lysine	41-47	elastin	Homo sapiens	119-126
6458449-1	1981	We have found that only 20 to 30% of the lysine residues measured after acid hydrolysis of insoluble elastin and alpha-elastin were blocked by prior guanidination of elastin with o-methylisourea.	Lysine	41-47	elastin	Homo sapiens	119-126
6458449-4	1981	Since photolysis of desmosine and isodesmosine leads also to the formation of new lysine residues, methods will have to be devised to distinguish lysine-containing peptides derived from photolyzed elastin.	Lysine	146-152	elastin	Homo sapiens	197-204
24560272-6	2014	Mechanistically, OTUB2 suppresses RNF8-mediated L3MBTL1 ubiquitination and Lys 63-linked ubiquitin chain formation in a deubiquitinating activity-dependent manner.	Lysine	75-78	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	17-22
24297471-2	2014	Carboxypeptidase-B (CBP-B) was used to selectively remove C-terminal arginine or lysine residues from phosphorylated tryptic/Lys-C peptides prior to their MS/MS analysis by CID with a Paul-type ion trap.	Lysine	81-87	carboxypeptidase B1	Homo sapiens	0-18
24297471-2	2014	Carboxypeptidase-B (CBP-B) was used to selectively remove C-terminal arginine or lysine residues from phosphorylated tryptic/Lys-C peptides prior to their MS/MS analysis by CID with a Paul-type ion trap.	Lysine	81-87	carboxypeptidase B1	Homo sapiens	20-25
22194015-1	2012	During the last decade, we saw an explosion of studies investigating the role of lysine methylation/demethylation of histones and non-histone proteins, such as p53, NF-kappaB, and E2F1.	Lysine	81-87	E2F transcription factor 1	Homo sapiens	180-184
23873758-7	2014	ChIP reChIP assays revealed that SirT1 and Set7/9 form a protein complex on the COL2A1 promoter region of 3D-cultured chondrocytes, which also demonstrated elevated trimethylated lysine 4 on histone 3 (3MeH3K4), a hallmark of Set7/9 methyltransferase activity.	Lysine	179-185	sirtuin 1	Homo sapiens	33-38
23318425-4	2014	DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.	Lysine	138-144	lysine acetyltransferase 5	Homo sapiens	54-59
6907016-4	1980	Evidence is put forward that a form of alpha 2-antiplasmin with less affinity for the lysine-binding sites in plasminogen may exist, even in unfractionated plasma.	Lysine	86-92	serpin family F member 2	Homo sapiens	39-58
23318425-4	2014	DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.	Lysine	138-144	E1A binding protein p400	Homo sapiens	60-64
22567286-6	2012	Point mutation of lysine residue in the SUMO motif compromised the ability of TCTP to get sumoylated in vitro.	Lysine	18-24	tumor protein, translationally-controlled 1	Homo sapiens	78-82
24416355-1	2014	The recessive opaque-2 mutant gene (o2) reduces alpha-zeins accumulation in maize endosperm, changes the amino acid composition of maize kernels, induces an opaque endosperm, and increases the lysine content of kernels.	Lysine	193-199	regulatory protein opaque-2	Zea mays	14-22
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	DExD/H-box helicase 58	Homo sapiens	108-113
7410376-2	1980	These reactions, which are directed principally towards the prothrombin substrate and the Factor V cofactor, are eliminated if the lysine residues of prothrombin are chemically modified beforehand with methyl acetimidate.	Lysine	131-137	coagulation factor II, thrombin	Bos taurus	60-71
7410376-2	1980	These reactions, which are directed principally towards the prothrombin substrate and the Factor V cofactor, are eliminated if the lysine residues of prothrombin are chemically modified beforehand with methyl acetimidate.	Lysine	131-137	coagulation factor II, thrombin	Bos taurus	150-161
7410376-3	1980	Amidinated prothrombin in which the usual lysine content has been reduced by 75% is cleaved completely by Factor Xa to give thrombin which has little or no activity towards fibrinogen, the thrombin-sensitive bond in prothrombin, or Factor V, but with normal activity towards the synthetic chromogenic substrate D-Phe-Pipecolyl-L-Arg-p-nitroanilide.	Lysine	42-48	coagulation factor II, thrombin	Bos taurus	11-22
7410376-3	1980	Amidinated prothrombin in which the usual lysine content has been reduced by 75% is cleaved completely by Factor Xa to give thrombin which has little or no activity towards fibrinogen, the thrombin-sensitive bond in prothrombin, or Factor V, but with normal activity towards the synthetic chromogenic substrate D-Phe-Pipecolyl-L-Arg-p-nitroanilide.	Lysine	42-48	coagulation factor II, thrombin	Bos taurus	14-22
7410376-3	1980	Amidinated prothrombin in which the usual lysine content has been reduced by 75% is cleaved completely by Factor Xa to give thrombin which has little or no activity towards fibrinogen, the thrombin-sensitive bond in prothrombin, or Factor V, but with normal activity towards the synthetic chromogenic substrate D-Phe-Pipecolyl-L-Arg-p-nitroanilide.	Lysine	42-48	coagulation factor II, thrombin	Bos taurus	124-132
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	DExD/H-box helicase 58	Homo sapiens	206-211
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	DExD/H-box helicase 58	Homo sapiens	76-106
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	DExD/H-box helicase 58	Homo sapiens	108-113
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	25-28	DExD/H-box helicase 58	Homo sapiens	206-211
24399297-3	2014	Conversely, Lys(48)-linked ubiquitylation of TRIM25 by the linear ubiquitin assembly complex (LUBAC) stimulates the proteasomal degradation of TRIM25, thereby inhibiting the RIG-I signaling pathway.	Lysine	12-15	DExD/H-box helicase 58	Homo sapiens	174-179
22001406-2	2012	In this study, we report that deleted azoospermia associated protein 1 (DAZAP1)/proline-rich RNA binding protein (Prrp), a multifunctional RNA binding protein which is essential for spermatogenesis and normal cell growth, is acetylated at Lysine 150 within its RNA binding domain.	Lysine	239-245	DAZ associated protein 1	Homo sapiens	72-78
24675890-5	2014	This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression.	Lysine	152-158	lysine demethylase 1A	Homo sapiens	36-40
24675890-5	2014	This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression.	Lysine	152-158	lysine demethylase 1A	Homo sapiens	84-88
24675890-5	2014	This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression.	Lysine	152-158	lysine demethylase 1A	Homo sapiens	84-88
6102568-4	1980	Incubation of the polypentapeptide at 55 degrees C, which enhances coacervation of the peptide, increases aldehyde formation and generates a much higher ratio of cross-linkages to aldehyde than occurred at 37 degrees C. These results demonstrate that lysyl oxidase can oxidize lysine in synthetic polypeptides and suggest important conformational aspects of lysyl oxidase substrates which may control substrate potential as well as the ability of peptidyl aldehyde, once formed by the enzyme, to condense to cross-linkage products.	Lysine	277-283	lysyl oxidase	Bos taurus	251-264
22562205-1	2012	The regulated removal of the gene-silencing epigenetic mark, trimethylation of lysine 27 of histone H3 (H3K27me3), has been shown to be critical for tissue-specific activation of developmental genes; however, the extent of embryonic expression of its demethylases, JMJD3 and UTX, has remained unclear.	Lysine	79-85	lysine (K)-specific demethylase 6B L homeolog	Xenopus laevis	265-270
6768552-1	1980	Two groups of crosslinked polyacrylic gels with immobilized lysine and lysine peptides (Lys)5 and (Lys)5-Pro have been used as models for the chromatographic investigation of lysine-peptide-oligonucleotide interactions.	Lysine	71-77	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	88-93
22013045-3	2012	By using glutathione S-transferase (GST) pulldowns, we identified an essential role of lysine 343 in VP16, mutation of which to a neutral amino acid abrogated the interaction between VP1/2 and VP16.	Lysine	87-93	glutathione S-transferase kappa 1	Homo sapiens	9-34
6249588-2	1980	Covalent spin labelling of lysine and arginine residues in histone H1 under specified conditions allows the study of histone-DNA interaction.	Lysine	27-33	spindlin 1	Homo sapiens	9-13
25274109-9	2014	KEGG pathway annotations using DIANA miRPath or targets predicted by Targetscan identified 7 pathways (Valine, leucine and isoleucine degradation; MAPK signaling pathway; Dorso-ventral axis formation; Propanoate metabolism; Sphingolipid metabolism; Lysine degradation; Jak- STAT signaling pathway) which might be influenced by these miRNAs.	Lysine	249-255	p38b MAP kinase	Drosophila melanogaster	147-151
22339171-3	2014	In our previous paper we showed that the MMP-9 enzyme recognizes a specific peptide sequence, Lys-Gly- Pro-Arg-Ser-Leu-Ser-Gly-Lys, and cleaves the peptide into two parts [1].	Lysine	94-97	matrix metallopeptidase 9	Homo sapiens	41-46
22013045-3	2012	By using glutathione S-transferase (GST) pulldowns, we identified an essential role of lysine 343 in VP16, mutation of which to a neutral amino acid abrogated the interaction between VP1/2 and VP16.	Lysine	87-93	glutathione S-transferase kappa 1	Homo sapiens	36-39
22339171-3	2014	In our previous paper we showed that the MMP-9 enzyme recognizes a specific peptide sequence, Lys-Gly- Pro-Arg-Ser-Leu-Ser-Gly-Lys, and cleaves the peptide into two parts [1].	Lysine	127-130	matrix metallopeptidase 9	Homo sapiens	41-46
30754-6	1978	Measurement of amino acid uptake show that the mutants with high glutamine synthetase levels have increased rates for glutamine, arginine, aspartate, and lysine, but a decreased rate for proline.	Lysine	154-160	type I glutamate--ammonia ligase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	65-85
23118980-5	2012	Here we report that NEDD8 is conjugated to RCAN1 (RCAN1-1S) via three lysine residues, K96, K104, and K107.	Lysine	70-76	regulator of calcineurin 1	Homo sapiens	43-48
619998-1	1978	A series of monocarboxylic and dicarboxylic acid sulfur-containing by-product analogues of lysine and arginine has been synthesized and tested as competitive inhibitors of bovine carboxypeptidase B.	Lysine	91-97	carboxypeptidase B1	Bos taurus	179-197
24190971-0	2014	LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.	Lysine	132-138	lysine demethylase 1A	Homo sapiens	0-4
24190971-4	2014	Here, we found that LSD1 interacts with histone deacetylase 1 (HDAC1) to regulate the proliferation of ES/EC cells through acetylation of histone H4 at lysine 16 (H4K16), which we show is a critical substrate of HDAC1.	Lysine	152-158	lysine demethylase 1A	Homo sapiens	20-24
24163099-4	2014	MDM2 activates chk1 phosphorylation, elevates mixed lineage lymphoma histone methyl transferase levels and promotes checkpoint-dependent tri-methylation of histone H3 at lysine 4, known to prevent firing of late replication origins at the early S phase.	Lysine	170-176	MDM2 proto-oncogene	Homo sapiens	0-4
24214534-1	2014	Quality Protein Maize (QPM) is a hard kernel variant of the high-lysine mutant opaque2.	Lysine	65-71	regulatory protein opaque-2	Zea mays	79-86
23118980-5	2012	Here we report that NEDD8 is conjugated to RCAN1 (RCAN1-1S) via three lysine residues, K96, K104, and K107.	Lysine	70-76	regulator of calcineurin 1	Homo sapiens	50-58
22808194-5	2012	We found that dCBP, which is encoded by the nejire gene, acetylates H3 lysine 23 in vivo, and silencing of nejire leads to reduced expression of the Eip74EF and Eip75B genes.	Lysine	71-77	sarcoplasmic calcium-binding protein	Drosophila melanogaster	14-18
24290762-4	2013	RIM1alpha SUMOylation at lysine residue K502 facilitates the clustering of CaV2.1 calcium channels and enhances the Ca(2+) influx necessary for vesicular release, whereas non-SUMOylated RIM1alpha participates in the docking/priming of synaptic vesicles and maintenance of active zone structure.	Lysine	25-31	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	75-81
24300896-5	2013	Additionally, interfering with the methylation of VEGFR-2 by pharmacological inhibition or by site-directed mutagenesis revealed that methylation of Lys(1041) was required for VEGFR-2-mediated angiogenesis in zebrafish and tumor growth in mice.	Lysine	149-152	kinase insert domain receptor like	Danio rerio	50-57
24300896-5	2013	Additionally, interfering with the methylation of VEGFR-2 by pharmacological inhibition or by site-directed mutagenesis revealed that methylation of Lys(1041) was required for VEGFR-2-mediated angiogenesis in zebrafish and tumor growth in mice.	Lysine	149-152	kinase insert domain receptor like	Danio rerio	176-183
890567-2	1977	In addition to variations for other amino acids, fraction H1 from rye contains twice as much arginine as the corresponding animal fraction; the plant H2B (PHI) and H2A (PHII) histones show lysine to arginine ratios greater than those of their animal counterparts.	Lysine	189-195	histone H2B type 2-E	Bos taurus	150-153
870063-5	1977	The amide III regions of the Raman spectra of the slightly lysine-rich histones H2A and H2B shows two bands at 1247 and 1265 cm-1 for H2A, and at 1254 and 1265 cm-1 for H2B.	Lysine	59-65	histone H2B type 2-E	Bos taurus	88-91
23973428-4	2013	Pyrophosphate released by the amino acid-aaRS binding reaction was detected by luminol chemiluminescence; the method provided selective quantitation of 1.0-30 muM histidine and 1.0-60 muM lysine.	Lysine	188-194	alanyl-tRNA synthetase 1	Homo sapiens	41-45
22808194-7	2012	Furthermore, along with previous studies identify CBP dependent H3 lysine 23 acetylation as an evolutionarily conserved chromatin modification involved in steroid induced gene activation.	Lysine	67-73	sarcoplasmic calcium-binding protein	Drosophila melanogaster	50-53
870063-5	1977	The amide III regions of the Raman spectra of the slightly lysine-rich histones H2A and H2B shows two bands at 1247 and 1265 cm-1 for H2A, and at 1254 and 1265 cm-1 for H2B.	Lysine	59-65	histone H2B type 2-E	Bos taurus	169-172
22662218-1	2012	BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in cancer cells.	Lysine	212-215	ubiquitin specific peptidase 17 like family member 9, pseudogene	Homo sapiens	44-49
265581-3	1977	The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys.	Lysine	160-163	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	67-70
265581-4	1977	Lysine 119, the amino terminus of this peptide, which is derived from the histone 2A portion of protein A24, is linked by an isopeptide bond to the carboxyl group of a glycine residue.	Lysine	0-6	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	104-107
24042460-5	2013	Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus.	Lysine	113-119	uncharacterized protein LOC700391	Macaca mulatta	0-6
24259290-7	2013	We show that merlin-mutant MSC have higher expression levels of SIRT2 and lower levels of overall lysine acetylation than wild-type control MSC.	Lysine	98-104	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	13-19
22479563-1	2012	Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins.	Lysine	68-74	carboxypeptidase M	Homo sapiens	0-18
23556418-5	2013	We found that DHDPS2 plays a crucial role in controlling lysine biosynthesis, thereby stabilizing flux through the whole aspartate pathway.	Lysine	57-63	dihydrodipicolinate synthase	Arabidopsis thaliana	14-20
1017794-5	1976	The deprotection of the alpha-amino group by HCl/acetic acid of Boc-Ile-Cys(SiPr)-Gly-Lys(Z) was accompanied by a disulfide exchange at the cysteine residue.	Lysine	86-89	BOC cell adhesion associated, oncogene regulated	Homo sapiens	64-67
24106268-2	2013	Jumonji domain-containing 3 (Jmjd3) is a histone demethylase, which specifically catalyzes the removal of trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	138-144	lysine demethylase 6B	Homo sapiens	0-27
22479563-1	2012	Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins.	Lysine	68-74	carboxypeptidase M	Homo sapiens	20-23
24106268-2	2013	Jumonji domain-containing 3 (Jmjd3) is a histone demethylase, which specifically catalyzes the removal of trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	138-144	lysine demethylase 6B	Homo sapiens	29-34
22006923-7	2011	Mutagenesis of TrbI showed that the conserved Lys-93 and Asp-155 are essential, whereas mutagenesis of Ser-52, the putative catalytic serine did not influence circularization.	Lysine	46-49	TrbI	Neisseria gonorrhoeae	15-19
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Lysine	97-100	insulin receptor related receptor	Homo sapiens	125-128
24260525-5	2013	In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607).	Lysine	63-69	ubiquitin specific peptidase 25	Homo sapiens	49-54
24260525-5	2013	In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607).	Lysine	78-84	ubiquitin specific peptidase 25	Homo sapiens	49-54
993202-1	1976	A highly sensitive and specific radioimmunoassay for neurotensin has been developed which utilizes 125I-labeled neurotensin and rabbit antisera raised toward synthetic neurotensin which has been coupled specifically through its lysine side chain to several proteins.	Lysine	228-234	neurotensin	Bos taurus	53-64
974098-5	1976	Carboxypeptidase B cleaved a C-terminal lysine from the different enzyme forms and shifted the isoelectric point of the different enzyme active bands towards the acid pH.	Lysine	40-46	carboxypeptidase B1	Homo sapiens	0-18
24883177-1	2014	Lysine specific demethylase 1 (LSD1) selectively removes methyl groups from mono- and dimethylated histone 3 lysine 4 (H3K4), resulting in gene silencing.	Lysine	109-115	lysine demethylase 1A	Homo sapiens	31-35
22158900-1	2011	Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively.	Lysine	11-17	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	121-125
22012064-2	2011	We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2 critical regulatory regions of the AML1 target gene PU.1.	Lysine	137-143	RUNX family transcription factor 1	Homo sapiens	60-65
24192352-5	2013	HSD is thus a crucial intermediate enzyme linked to the biosynthesis of several essential amino acids such as lysine, methionine, isoleucine and threonine.	Lysine	110-116	AT695_RS10950	Staphylococcus aureus	0-3
23957292-7	2013	However, a mutant generated by replacing the lysine residue with a positively charged amino acid arginine (K1110R) displayed channel activity similar to wild-type TRPM2.	Lysine	45-51	transient receptor potential cation channel subfamily M member 2	Homo sapiens	163-168
61969-1	1976	Antibodies directed against whole histone and purified lysine-rich histone H1 extracted from isolated macronuclei of the ciliate Tetrahymena were obtained and conjugated to fluorescein isothiocyanate.	Lysine	55-61	H1.0 linker histone	Homo sapiens	67-77
22012064-2	2011	We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2 critical regulatory regions of the AML1 target gene PU.1.	Lysine	137-143	RUNX family transcription factor 1	Homo sapiens	67-71
22012064-2	2011	We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2 critical regulatory regions of the AML1 target gene PU.1.	Lysine	137-143	lysine methyltransferase 2A	Homo sapiens	77-80
22012064-2	2011	We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2 critical regulatory regions of the AML1 target gene PU.1.	Lysine	137-143	RUNX family transcription factor 1	Homo sapiens	211-215
24186071-3	2013	Importantly, both CFP1 and KDM2A are associated with enzymatic activities that modulate specific histone lysine methylation marks.	Lysine	105-111	lysine demethylase 2A	Homo sapiens	27-32
1245189-2	1976	Digestion of calf thymus H1 histone with thrombin cleaves the molecule at the sequence -(Pro)-Lys-Lys-Ala-, corresponding to a point approximately 122 residues from the N-terminus (about 56% along the molecule).	Lysine	94-97	coagulation factor II, thrombin	Bos taurus	41-49
22084441-9	2011	These associations depended on a transmembrane lysine residue in CD94 that is unique to rodents.	Lysine	47-53	killer cell lectin like receptor D1	Rattus norvegicus	65-69
1245189-2	1976	Digestion of calf thymus H1 histone with thrombin cleaves the molecule at the sequence -(Pro)-Lys-Lys-Ala-, corresponding to a point approximately 122 residues from the N-terminus (about 56% along the molecule).	Lysine	98-101	coagulation factor II, thrombin	Bos taurus	41-49
24096875-5	2013	In the infarct heart, p53 was heavily acetylated at Lys(118) residue, which was exclusively reversed in the oxygenated heart, apparently regulated by oxygen-dependent expression of TIP60.	Lysine	52-55	lysine acetyltransferase 5	Homo sapiens	181-186
21893106-3	2011	In the present study, we describe the design, synthesis and characterization of a truncated, 18-amino acid analog of ghrelin conjugated to a fluorescent molecule, fluorocein isothiocyanate (FITC), through the addition of a lysine at its C terminus ([Dpr(octanoyl)(3), Lys(fluorescein)(19)]ghrelin(1-19)).	Lysine	223-229	appetite-regulating hormone	Cricetulus griseus	117-124
24044355-2	2013	STIM1 (stromal interaction molecule 1) and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoinositides at the PM via their cytosolic lysine (K)-rich domains, and activate Ca2+ channels.	Lysine	167-173	stromal interaction molecule 2	Homo sapiens	43-48
24108357-4	2013	Our results suggest that SUMOylation of Snf1 inhibits its function in two ways: by interaction of SUMO attached to lysine 549 with a SUMO-interacting sequence motif located near the active site of Snf1, and by targeting Snf1 for destruction via the Slx5-Slx8 (SUMO-directed) ubiquitin ligase.	Lysine	115-121	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	249-253
1234647-4	1975	The insolubility of elastin increased with age, together with the increasing crosslinkage of the fiber, characterized by the ratio (sum of desmosines/lysine).	Lysine	150-156	elastin	Homo sapiens	20-27
21893106-3	2011	In the present study, we describe the design, synthesis and characterization of a truncated, 18-amino acid analog of ghrelin conjugated to a fluorescent molecule, fluorocein isothiocyanate (FITC), through the addition of a lysine at its C terminus ([Dpr(octanoyl)(3), Lys(fluorescein)(19)]ghrelin(1-19)).	Lysine	223-229	appetite-regulating hormone	Cricetulus griseus	289-296
21893106-3	2011	In the present study, we describe the design, synthesis and characterization of a truncated, 18-amino acid analog of ghrelin conjugated to a fluorescent molecule, fluorocein isothiocyanate (FITC), through the addition of a lysine at its C terminus ([Dpr(octanoyl)(3), Lys(fluorescein)(19)]ghrelin(1-19)).	Lysine	268-272	appetite-regulating hormone	Cricetulus griseus	117-124
1091734-2	1975	Four analogs of ovine somatostatin (SRIF, PSOMATOTROPIN RELEASE INhibiting factor), the sequence of which is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, have been synthesized by the solid-phase methodology.	Lysine	123-126	somatostatin	Homo sapiens	22-34
24194938-0	2013	Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro.	Lysine	15-21	mediator of DNA damage checkpoint 1	Homo sapiens	108-112
24194938-5	2013	We further show that both acetylation of lysine 382 and phosphorylation of serine 392 in p53 enhance the interaction between p53 and MDC1.	Lysine	41-47	mediator of DNA damage checkpoint 1	Homo sapiens	133-137
21845734-2	2011	HLTF promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) that is required for maintaining genomic stability.	Lysine	18-21	helicase like transcription factor	Homo sapiens	0-4
24194938-7	2013	Our data suggests a new role for acetylation of lysine 382 and phosphorylation of serine 392 in p53 in the cellular stress response and offers the first evidence for an interaction involving MDC1 that is modulated by acetylation.	Lysine	48-54	mediator of DNA damage checkpoint 1	Homo sapiens	191-195
24006281-2	2013	Previous studies revealed that the JmjC domain-containing protein KDM3A possesses intrinsic demethylase activity toward lysine 9 of histone H3 and plays essential roles in spermiogenesis.	Lysine	120-126	lysine (K)-specific demethylase 3A	Mus musculus	66-71
5134532-0	1971	Pyridoxal 5"-phosphate as a site-specific protein reagent for a catalytically critical lysine residue in rabbit muscle phosphoglucose isomerase.	Lysine	87-93	glucose-6-phosphate isomerase	Oryctolagus cuniculus	119-143
21845734-2	2011	HLTF promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) that is required for maintaining genomic stability.	Lysine	18-21	proliferating cell nuclear antigen	Homo sapiens	54-88
21845734-2	2011	HLTF promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) that is required for maintaining genomic stability.	Lysine	18-21	proliferating cell nuclear antigen	Homo sapiens	90-94
24013172-5	2013	Dnmt1 depletion results in a marked accumulation of Uhrf1-dependent ubiquitylation of histone H3 at lysine 23.	Lysine	100-106	DNA methyltransferase 1	Homo sapiens	0-5
22312702-5	2011	The PEG-ylated L-asparaginase consisted of different isomers from mono to multi PEG-ylated depending upon the number of Lysine residues (14 in case of L-asparaginase) with about 5% as native protein.	Lysine	120-126	progestagen associated endometrial protein	Homo sapiens	4-7
24013172-5	2013	Dnmt1 depletion results in a marked accumulation of Uhrf1-dependent ubiquitylation of histone H3 at lysine 23.	Lysine	100-106	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	52-57
4911552-8	1970	Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers.	Lysine	105-118	cathepsin D	Bos taurus	198-209
22004540-3	2011	On the basis of the average percentages of labeling obtained for the lysine and arginine residues by peptide mapping analysis, the positive charges were more distributed on the surface in the Fab region than in the Fc region of rmAb1.	Lysine	69-75	FA complementation group B	Homo sapiens	192-195
5762190-1	1969	Several cross-linking substances which derive from lysine have been isolated from hydrolyzates of collagen and elastin.	Lysine	51-57	elastin	Homo sapiens	111-118
23881913-6	2013	On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.	Lysine	138-145	forkhead box O3	Mus musculus	64-70
23881913-6	2013	On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.	Lysine	138-145	sterol regulatory element binding factor 2	Mus musculus	78-84
22082911-7	2011	A nearby cysteine then reacts with the lysine adduct to form a carbonyl crosslink in the OGT active site.	Lysine	39-45	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	89-92
23842000-4	2013	Using the chromodomain of human chromobox protein homolog 6 as a model system, we developed a systematic approach that integrates structure modeling, bioinformatics analysis, and peptide microarray experiments to identify lysine residues that are methylated and recognized by the chromodomain in the human proteome.	Lysine	222-228	chromobox 6	Homo sapiens	32-59
23884442-8	2013	Further dissection of the DCC via RNAi revealed that other complex members phenocopy the dpy-21 suppression of rict-1, as did RNAi to the DCC effectors set-1 and set-4, which methylate histone 4 on lysine 20 (H4K20).	Lysine	198-204	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	152-157
5941783-3	1966	Chemical studies of elastin isolated from the aortas of control and lathyritic chicks showed an apparent loss of lysine residues in control elastin to be associated with an increase in aldehyde content providing evidence that lysine is converted to an aldehyde-containing intermediate during biosynthesis of desmosine and isodesmosine.	Lysine	113-119	elastin	Homo sapiens	140-147
5941783-3	1966	Chemical studies of elastin isolated from the aortas of control and lathyritic chicks showed an apparent loss of lysine residues in control elastin to be associated with an increase in aldehyde content providing evidence that lysine is converted to an aldehyde-containing intermediate during biosynthesis of desmosine and isodesmosine.	Lysine	226-232	elastin	Homo sapiens	20-27
5941783-3	1966	Chemical studies of elastin isolated from the aortas of control and lathyritic chicks showed an apparent loss of lysine residues in control elastin to be associated with an increase in aldehyde content providing evidence that lysine is converted to an aldehyde-containing intermediate during biosynthesis of desmosine and isodesmosine.	Lysine	226-232	elastin	Homo sapiens	140-147
5941783-5	1966	At least two types of aldehydes, saturated and alpha,beta-unsaturated, appear to be associated with elastin, suggesting the presence of more than one intermediate between lysine and the desmosines.	Lysine	171-177	elastin	Homo sapiens	100-107
14171571-1	1964	Preliminary tests have shown that the endosperms of maize seeds homozygous for the opaque-2 mutant gene have a higher lysine content than normal kernels.	Lysine	118-124	regulatory protein opaque-2	Zea mays	83-91
21841182-1	2011	Previous studies established that the Class-1 PEPC (PTPC homotetramer) of castor oil seeds (COS) is activated by phosphorylation at Ser-11 and inhibited by monoubiquitination at Lys-628 during endosperm development and germination, respectively.	Lysine	178-181	LOC8259391	Ricinus communis	46-50
14171571-3	1964	The opaque-2 endosperms had a different amino acid pattern and 69 percent more lysine than the normal seeds.	Lysine	79-85	regulatory protein opaque-2	Zea mays	4-12
23718933-12	2013	The ICER for RT/GC+GC was $97,799 per PF-LYS.	Lysine	41-44	cAMP responsive element modulator	Homo sapiens	4-8
21880724-7	2011	Structural superpositions onto the distant homolog FtsH imply that the paddles extend away from the hexameric toroid in a fan-like fashion, such that the hydrophobic sides of each blade bearing Trp-302 are facing inward and the polar sides bearing Lys-313 and Val-316 are facing outward.	Lysine	248-251	YME1 like 1 ATPase	Homo sapiens	51-55
23723075-4	2013	Recently, it was shown that acetylation of lysine 104 attenuates K-RAS transforming activity by interfering with GEF-induced nucleotide exchange.	Lysine	43-49	KRAS proto-oncogene, GTPase	Homo sapiens	65-70
23723075-4	2013	Recently, it was shown that acetylation of lysine 104 attenuates K-RAS transforming activity by interfering with GEF-induced nucleotide exchange.	Lysine	43-49	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	114-120	PTEN induced kinase 1	Homo sapiens	148-153
23885119-4	2013	SARM1, which is known to be an adaptor protein for Toll-like receptor, binds to PINK1 and promotes TRAF6-mediated lysine 63 chain ubiquitination of PINK1 at lysine 433.	Lysine	157-163	PTEN induced kinase 1	Homo sapiens	148-153
34003252-1	2021	The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs).	Lysine	48-54	lysine demethylase 5A	Homo sapiens	24-29
33077306-8	2021	In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression.	Lysine	115-117	cadherin 2	Homo sapiens	53-63
21856913-2	2011	However, short-term SIRT1-mediated lysine deacetylation, within the context of acute cardioprotection, is poorly understood.	Lysine	35-41	sirtuin 1	Mus musculus	20-25
22630345-0	2013	Stabilization of ferrochelatase via lysine residues on the carboxyl terminal extension.	Lysine	36-42	ferrochelatase	Homo sapiens	17-31
21856913-5	2011	Consistent with a role for SIRT1 in IPC, SIRT1(+/-) hearts could not be preconditioned and exhibited increased cytosolic lysine acetylation.	Lysine	121-127	sirtuin 1	Mus musculus	41-46
22630345-12	2013	The lysine and tryptophan residues serve as a structure determinant of ferrochelatase.	Lysine	4-10	ferrochelatase	Homo sapiens	71-85
21856913-9	2011	In conclusion, these data suggest that SIRT1, acting on nontranscriptional targets, is required for cardioprotection by acute IPC and that SIRT1-dependent lysine deacetylation occurs during IPC and may play a role in cardioprotective signaling.	Lysine	155-161	sirtuin 1	Mus musculus	139-144
21784112-8	2011	Thus, possible protective or inducing effects of lys, Cu(2+) and Zn(2+) may exist with alpha-syn.	Lysine	49-52	synuclein alpha	Homo sapiens	87-96
34035379-7	2021	Interestingly, Rcn3 deficient mice exhibited a smaller collagen fibril distribution and over-hydroxylation in C-telopeptide cross-linking lysine from alpha1(1) chain.	Lysine	138-144	reticulocalbin 3, EF-hand calcium binding domain	Mus musculus	15-19
21768087-5	2011	The E3 ubiquitin ligases c-Cbl and to a lesser extent Cbl-b facilitated at least partly Lys-48-linked polyubiquitination of autophosphorylated Flt3-ITD when coexpressed in 293T cells.	Lysine	88-91	Cbl proto-oncogene	Homo sapiens	25-30
34030685-5	2021	In Drosophila, the histone H3 lysine 9 (H3K9) methyltransferase G9a was shown to mediate tolerance to virus infection and oxidative stress (OS), suggesting that abiotic stresses like OS may also evoke tolerance mechanisms.	Lysine	30-36	G9a	Drosophila melanogaster	64-67
24027420-0	2013	Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3zeta, MSK1, and MKP1.	Lysine	77-83	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	137-147
23932781-3	2013	Here we show that ACLY is acetylated at lysine residues 540, 546, and 554 (3K).	Lysine	40-46	ATP citrate lyase	Homo sapiens	18-22
23932781-4	2013	Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation.	Lysine	27-33	ATP citrate lyase	Homo sapiens	171-175
34006870-5	2021	PLK1 transcript levels are shown to be regulated by an unmutated lysine methyl-transferase (KMT2A) resulting in increased promoter monomethylation of lysine 4 of histone 3.	Lysine	65-71	polo like kinase 1	Mus musculus	0-4
34006870-5	2021	PLK1 transcript levels are shown to be regulated by an unmutated lysine methyl-transferase (KMT2A) resulting in increased promoter monomethylation of lysine 4 of histone 3.	Lysine	150-156	polo like kinase 1	Mus musculus	0-4
21768087-5	2011	The E3 ubiquitin ligases c-Cbl and to a lesser extent Cbl-b facilitated at least partly Lys-48-linked polyubiquitination of autophosphorylated Flt3-ITD when coexpressed in 293T cells.	Lysine	88-91	Cbl proto-oncogene B	Homo sapiens	54-59
21523786-8	2011	A significant negative correlation was observed between the trimethylation of lysine-9 on histone H3 (H3K9me3) and the OCT2 mRNA levels.	Lysine	78-84	solute carrier family 22 member 2	Homo sapiens	119-123
33960373-3	2021	In addition, aldehydes can form Schiff"s base reactions with protein lysines to form oxidised lipid:protein adducts.	Lysine	69-76	tryptophan 2,3-dioxygenase	Homo sapiens	77-79
33977095-11	2021	The recruitment of WDR5 to the promoter of these target genes upregulated the histone H3 lysine 4 trimethylation (H3K4me3) level in these regions and further induced the transcription of MMP2, MMP9, CDK1, CDK2, and CDK4.	Lysine	89-95	matrix metallopeptidase 2	Mus musculus	187-191
23900215-7	2013	The LSD1 physically interacted with the promoter of CDH-1 and decreased dimethyl histone H3 lysine 4 (H3K4) at this region, downregulated CDH-1 expression, and consequently contributed to colon cancer metastasis.	Lysine	92-98	lysine demethylase 1A	Homo sapiens	4-8
21642393-7	2011	Comparative modeling with OATP1A2 and OATP2B1 revealed that the pore size around this lysine residue is larger in OATP1A2 and smaller in OATP2B1 compared with OATP1B3, which could be related to the respective substrate spectra.	Lysine	86-92	solute carrier organic anion transporter family member 2B1	Homo sapiens	137-144
23792041-2	2013	We recently reported that synthetic biotinylated peptides having a Tyr-Lys-Asp-Gly sequence inhibit PAF-induced inflammation by directly binding to PAF.	Lysine	71-74	PCNA clamp associated factor	Rattus norvegicus	100-103
23792041-2	2013	We recently reported that synthetic biotinylated peptides having a Tyr-Lys-Asp-Gly sequence inhibit PAF-induced inflammation by directly binding to PAF.	Lysine	71-74	PCNA clamp associated factor	Rattus norvegicus	148-151
23792041-7	2013	These results provide evidence that the Tyr-Lys-Asp region in both ET-3 and BPET3 is essential for marked inhibition of the peptide on PAF-induced inflammation, and strongly suggest that BPET3 may be useful as a novel anti-inflammatory drug targeting PAF.	Lysine	44-47	PCNA clamp associated factor	Rattus norvegicus	135-138
33890127-8	2021	H-MP1 is a synthetic analog of MP1 with lysines replaced by histidines.	Lysine	40-47	pitrilysin metallopeptidase 1	Homo sapiens	2-5
21788519-6	2011	Repression of NRT2.1 transcription by high N supply is associated with an HNI9/AtIWS1-dependent increase in histone H3 lysine 27 trimethylation at the NRT2.1 locus.	Lysine	119-125	Transcription elongation factor (TFIIS) family protein	Arabidopsis thaliana	74-78
23871208-5	2013	PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TRAF3 lysine 63-linked ubiquitination.	Lysine	92-98	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	0-6
23871208-5	2013	PTPN22 directly associated with TNF receptor-associated factor 3 (TRAF3) and promotes TRAF3 lysine 63-linked ubiquitination.	Lysine	92-98	TNF receptor associated factor 3	Homo sapiens	86-91
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	protein arginine methyltransferase 7	Homo sapiens	143-179
21788519-6	2011	Repression of NRT2.1 transcription by high N supply is associated with an HNI9/AtIWS1-dependent increase in histone H3 lysine 27 trimethylation at the NRT2.1 locus.	Lysine	119-125	Transcription elongation factor (TFIIS) family protein	Arabidopsis thaliana	79-85
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Lysine	55-61	protein arginine methyltransferase 7	Homo sapiens	181-186
21746811-3	2011	In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (Smu) bearing H3K9me3 (trimethylated histone H3 at lysine 9) in vivo.	Lysine	236-242	chromobox 5	Homo sapiens	114-139
33398850-3	2021	PPARgamma influences global gene expression via its regulation of the epigenetic modifier lysine methyltransferase 5A (KMT5A), which places a methyl group on histone 4 lysine 20 (H4K20me) of target genes.	Lysine	90-96	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
33398850-3	2021	PPARgamma influences global gene expression via its regulation of the epigenetic modifier lysine methyltransferase 5A (KMT5A), which places a methyl group on histone 4 lysine 20 (H4K20me) of target genes.	Lysine	90-96	lysine methyltransferase 5A	Rattus norvegicus	119-124
33922150-2	2021	Here, we investigate the effects of the pH solution on MP1 (IDWKKLLDAAKQIL-NH2) adsorption to anionic (7POPC:3POPG) lipid vesicles in comparison to its analog H-MP1, with histidines substituting lysines.	Lysine	195-202	pitrilysin metallopeptidase 1	Homo sapiens	55-58
33880981-3	2021	In mammals, there are seven sirtuin isoforms (SIRT-1-7) that catalyze specific lysine substrate deacetylation.	Lysine	79-85	sirtuin 1	Homo sapiens	46-54
33892042-0	2021	Poly-l-Lysine inhibits VEGF and c-Myc mediated tumor-angiogenesis and induces apoptosis in 2D and 3D tumor microenvironment of both MDA-MB-231 and B16F10 induced mice model.	Lysine	0-13	vascular endothelial growth factor A	Mus musculus	23-27
33533576-1	2021	Lysine-specific demethylase 1 (LSD1/KDM1A) oxidatively removes methyl groups from histone proteins, and its aberrant activity has been correlated with cancers including acute myeloid leukemia (AML).	Lysine	0-6	lysine demethylase 1A	Homo sapiens	31-35
33533576-1	2021	Lysine-specific demethylase 1 (LSD1/KDM1A) oxidatively removes methyl groups from histone proteins, and its aberrant activity has been correlated with cancers including acute myeloid leukemia (AML).	Lysine	0-6	lysine demethylase 1A	Homo sapiens	36-41
33924051-4	2021	We found that a heterozygous tnnt2a mutation deleting Arginine at position 94 and Lysine at position 95 of TnT causes progressive cardiac structural changes resulting in heart failure.	Lysine	82-88	troponin T type 2a (cardiac)	Danio rerio	29-35
33935733-1	2021	Lysine-specific demethylase1 (KDM1A) is generally highly expressed in various cancer tissues, and promotes the initiation and development of cancers via diverse cellular signaling pathways.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	30-35
33936072-5	2021	The mono-CD16+ cell population in COVID-19 patients showed reduced transcription levels of genes related to lysine degradation (NSD1, KMT2E, and SETD2) and elevated transcription levels of genes involved in OXPHOS (ATP6V1B2, ATP5A1, ATP5E, and ATP5B), which may inhibit M2-like polarization.	Lysine	108-114	Fc gamma receptor IIIa	Homo sapiens	9-13
33493670-0	2021	C-terminal lysine clipping of IgG1: impact on binding to human FcgammaRIIIa and neonatal Fc receptors.	Lysine	11-17	Fc gamma receptor IIIa	Homo sapiens	63-75
33734501-5	2021	Through the set of systematic mass spectrometry analyses conducted on SMURF2-modified cells, we identified on PARP1 18 lysine residues (out of 126 present in PARP1) as sites which ubiquitination was considerably affected by SMURF2.	Lysine	119-125	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	70-76
33734501-5	2021	Through the set of systematic mass spectrometry analyses conducted on SMURF2-modified cells, we identified on PARP1 18 lysine residues (out of 126 present in PARP1) as sites which ubiquitination was considerably affected by SMURF2.	Lysine	119-125	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	224-230
33037615-7	2021	Further analyses revealed that the TRPM8 N-terminal lysine residue at 423 was the major ubiquitination site that mediates its functional regulation by TRIM4.	Lysine	52-58	tripartite motif containing 4	Homo sapiens	151-156
33053230-6	2021	Lysine 114 in FBXL19 is a potential ubiquitin acceptor site.	Lysine	0-6	F-box and leucine rich repeat protein 19	Homo sapiens	14-20
33359755-4	2021	Here, we identify interactions between the histone H3 lysine 27 trimethylation (H3K27me3) - demethylase JMJD3, the SWI/SNF remodeling complex subunit BRG1, and cardiac transcription factors.	Lysine	54-60	lysine demethylase 6B	Homo sapiens	104-109
33789369-8	2021	The small interfering RNA of KDM6B (KDM6B siRNA) was used to silence the expression of KDM6B and the protein levels of KDM6B, F4/80 and tri-methylation of lysine 27 of histone H3 (H3K27me3) induced by HBx gene transfection were detected by Western blotting.	Lysine	155-161	lysine demethylase 6B	Homo sapiens	29-34
33789369-8	2021	The small interfering RNA of KDM6B (KDM6B siRNA) was used to silence the expression of KDM6B and the protein levels of KDM6B, F4/80 and tri-methylation of lysine 27 of histone H3 (H3K27me3) induced by HBx gene transfection were detected by Western blotting.	Lysine	155-161	lysine demethylase 6B	Homo sapiens	36-41
33789369-8	2021	The small interfering RNA of KDM6B (KDM6B siRNA) was used to silence the expression of KDM6B and the protein levels of KDM6B, F4/80 and tri-methylation of lysine 27 of histone H3 (H3K27me3) induced by HBx gene transfection were detected by Western blotting.	Lysine	155-161	lysine demethylase 6B	Homo sapiens	36-41
33789369-8	2021	The small interfering RNA of KDM6B (KDM6B siRNA) was used to silence the expression of KDM6B and the protein levels of KDM6B, F4/80 and tri-methylation of lysine 27 of histone H3 (H3K27me3) induced by HBx gene transfection were detected by Western blotting.	Lysine	155-161	lysine demethylase 6B	Homo sapiens	36-41
33723063-3	2021	Here, we show that, upon DSB induction, the key resection factor CtIP is modified by the ubiquitin-like protein SUMO at lysine 578 in a PIAS4-dependent manner.	Lysine	120-126	protein inhibitor of activated STAT 4	Homo sapiens	136-141
33581557-1	2021	Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising target for the discovery of specific inhibitors as antitumor drugs.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	31-35
33581557-1	2021	Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising target for the discovery of specific inhibitors as antitumor drugs.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	36-41
33796551-4	2021	Mechanistically, ASXL1 forms a complex with BAP1 for the erasure of mono-ubiquitylation at lysine 119 on Histone H2A (H2AK119ub1), a well-known histone mark associated with transcription repression.	Lysine	91-97	ASXL transcriptional regulator 1	Homo sapiens	17-22
32810572-3	2021	In our study, we investigated the effects of 15-day social defeat stress (SDS) on the genome-wide landscape of trimethylation at the 4th lysine residue of histone H3 (H3K4me3) and on the transcriptome in the prefrontal cortex of mice that were reared normally (group SDS) or subjected to maternal separation early in life (group MS + SDS).	Lysine	137-143	H3 clustered histone 7	Mus musculus	155-165
33755924-1	2021	BACKGROUND: Vafidemstat, an inhibitor of the histone lysine-specific demethylase KDM1A, corrects cognition deficits and behavior alterations in rodent models.	Lysine	53-59	lysine demethylase 1A	Homo sapiens	81-86
32700783-3	2021	Strikingly, we found that increased di-, and tri-methylation of histone H3 lysine 9 (H3K9me2 and H3K9me3) expression were associated with upregulation of methyltransferase G9a and downregulation of endothelial nitric oxide synthase and CuZn-SOD expression in preeclamptic HUVECs.	Lysine	75-81	euchromatic histone lysine methyltransferase 2	Homo sapiens	172-175
32772228-3	2021	EZH2 is a histone methyltransferase that catalyzes histone 3 tri-methylation at lysine 27 (H3K27me3), resulting in gene silencing.	Lysine	80-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
33288957-2	2021	Various combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide bonds between the C terminus of their transiently linked donor ubiquitin and a specific nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental feature of most acceptors-the lysine side chain-affects catalysis.	Lysine	302-308	cystatin 12, pseudogene	Homo sapiens	24-33
33649337-4	2021	In vitro, S100beta/Sca1 cells isolated from atheroprone regions of the mouse aorta expressed hedgehog signalling components, acquired the di-methylation of histone 3 lysine 4 (H3K4me2) stable SMC epigenetic mark at the Myh11 locus and underwent myogenic differentiation in response to recombinant sonic hedgehog (SHh).	Lysine	166-172	ataxin 1	Mus musculus	19-23
33632299-1	2021	BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer.	Lysine	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	128-132
33632299-1	2021	BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer.	Lysine	61-67	H3 clustered histone 7	Mus musculus	73-83
33632299-1	2021	BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer.	Lysine	61-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	128-132
33718701-0	2021	Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.	Lysine	53-59	euchromatic histone lysine methyltransferase 2	Homo sapiens	49-52
33718701-4	2021	Several substrate competitive inhibitors are reported for the potent inhibition of G9a by incorporating lysine mimic groups in the inhibitor design.	Lysine	104-110	euchromatic histone lysine methyltransferase 2	Homo sapiens	83-86
33718701-10	2021	Moreover, the presence of both lysine and arginine mimics together shows a drastic increase in the binding affinity of the inhibitor towards G9a.	Lysine	31-37	euchromatic histone lysine methyltransferase 2	Homo sapiens	141-144
33608392-1	2021	The Ezh2 gene encodes a histone methyltransferase of the Polycomb Repressive Complex 2 that methylates histone H3 lysine 27.	Lysine	114-120	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	4-8
33680286-6	2021	Furthermore, deletion of GCN5L1 could reduce MnSOD acetylation on lysine 68 and activate its activity, thereby scavenging excessive ROS and relieving oxidative stress-induced renal inflammation and fibrosis.	Lysine	66-72	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	25-31
33574238-2	2021	In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark of trimethylated lysine 4 and lysine 9 present on the same histone H3 tail (H3K4me3K9me3).	Lysine	179-185	spindlin 1	Homo sapiens	66-75
33574238-2	2021	In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark of trimethylated lysine 4 and lysine 9 present on the same histone H3 tail (H3K4me3K9me3).	Lysine	192-198	spindlin 1	Homo sapiens	66-75
33573992-10	2021	A quadratic increase (P < 0.05) was found in both ADG and G:F when SID Lys content increased in the diets from day 14 to 21.	Lysine	71-74	ADG	Sus scrofa	50-53
33573992-11	2021	During the overall experimental period, increasing dietary Lys content quadratically increased (P < 0.05) ADG and G:F, whereas plasma urea nitrogen quadratically decreased (P < 0.05) as SID Lys content increased.	Lysine	59-62	ADG	Sus scrofa	106-109
33249170-1	2021	Background Microbial transglutaminase (mTG) has been successfully used to produce site-specific protein conjugates derivatized at the level of Gln and/or Lys residues for different biotechnological applications.	Lysine	154-157	protease, serine 3	Mus musculus	39-42
33249170-2	2021	Here, a recombinant peptide identified in human apolipoprotein B sequence, named r(P)ApoBL and endowed with antimicrobial activity, was studied as a possible acyl acceptor substrate of mTG with at least one of the six Lys residues present in its sequence.	Lysine	218-221	protease, serine 3	Mus musculus	185-188
33249170-7	2021	In particular, it was demonstrated the highly selective crosslinking of the peptide under study by mTG at level of Lys-18.	Lysine	115-118	protease, serine 3	Mus musculus	99-102
32895487-8	2021	We identified the lysine 133 (K133) residue in Oct4 as a ubiquitination site responsible for the Kap1-Itch-dependent regulation of Oct4 stability.	Lysine	18-24	POU domain, class 5, transcription factor 1	Mus musculus	47-51
32895487-8	2021	We identified the lysine 133 (K133) residue in Oct4 as a ubiquitination site responsible for the Kap1-Itch-dependent regulation of Oct4 stability.	Lysine	18-24	POU domain, class 5, transcription factor 1	Mus musculus	131-135
33385272-1	2021	Studies were conducted to understand the role of C-terminal lysine residues in the catalytic activity, structural stability and oligomeric properties of Staphylococcus aureus enolase.	Lysine	60-66	AT695_RS13760	Staphylococcus aureus	175-182
33385272-9	2021	The C-terminal lysine residues in the inter-dimer groove aid in folding and oligomerization of S. aureus enolase.	Lysine	15-21	AT695_RS13760	Staphylococcus aureus	105-112
33505024-8	2021	Using clonal analysis, we show that the global levels of some chromatin marks, such as H3 trimethylation at lysine 27 (H3K27me3) and macroH2A1 (mH2A1), are heritable over at least 3-4 generations, whereas other marks fluctuate on a faster time scale.	Lysine	108-114	H2A clustered histone 4	Mus musculus	144-149
33323973-4	2021	Then, we identified its upstream regulator UBE2T which promotes GC progression via hyperactivating the Wnt/beta-catenin signaling pathway through the ubiquitination and degradation of RACK1 at the lysine K172, K225, and K257 residues independent of an E3 ligase.	Lysine	197-203	receptor for activated C kinase 1	Homo sapiens	184-189
33520978-7	2020	It has been confirmed that miR-202-3p negatively regulated KDM3A responsible for increasing the expression of HOXA1 by eliminating the histone H3 lysine 9 (H3K9)me2 in HCC cells.	Lysine	146-152	lysine demethylase 3A	Homo sapiens	59-64
33290558-7	2021	For instance, YEATS2 but not the other YEATS proteins exhibits best preference for Kbz than lysine acetylation and crotonylation due to its wider "tip-sensor" pocket.	Lysine	92-98	YEATS domain containing 2	Mus musculus	14-20
33414395-10	2021	Specifically, FAT10 bound to the lysine residues in the C-terminal fragments of Nav1.5 and decreased the binding of Nav1.5 to the Nedd4-2 protein, a ubiquitin E3 ligase, preventing degradation of the Nav1.5 protein.	Lysine	33-39	sodium channel, voltage-gated, type V, alpha	Mus musculus	80-86
33397384-3	2021	Therefore, we designed this study to investigate effects of SUV39H2 in OS meditated by the lysine specific demethylase-1/E-cadherin (LSD1/CDH1) axis.	Lysine	91-97	lysine demethylase 1A	Homo sapiens	133-137
33389163-5	2021	In stage (ii), hydroxy group of water would help to break the bond between beta-NH2 group of L-lysine and PLP better than that of Tyr389.	Lysine	93-101	proteolipid protein 1	Homo sapiens	106-109
31373129-8	2021	Upregulation of KDM6B protein in alcohol-dependent rats was accompanied by a decrease of trimethylation levels at histone H3, lysine 27 (H3K27me3), consistent with the known demethylase specificity of KDM6B.	Lysine	126-132	lysine demethylase 6B	Rattus norvegicus	16-21
32600091-11	2021	Finally, we found an enriched histone H3 on lysine 27 acetylation existed in the promoter of CCR6, whose expression could also be changed via C646 in a time- and concentration-dependent manner.	Lysine	44-50	C-C motif chemokine receptor 6	Homo sapiens	93-97
33367935-3	2021	Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway.	Lysine	34-40	lysine demethylase 1A	Homo sapiens	50-76
33151142-0	2021	Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expression.	Lysine	0-6	SH2 domain containing 3A	Homo sapiens	38-42
33151142-5	2021	Specifically, bioinformatics and biochemical experiments showed that by interacting with 40S ribosomal subunit, the lysine located at amino acid 164 (K164) was the key residue that enabled SARS-CoV-2 nsp1 to suppress host gene expression.	Lysine	116-122	SH2 domain containing 3A	Homo sapiens	200-204
33200442-1	2021	Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of alpha-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation.	Lysine	174-180	aldehyde dehydrogenase 7 family member A1	Homo sapiens	31-34
33200442-1	2021	Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of alpha-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation.	Lysine	174-180	aldehyde dehydrogenase 7 family member A1	Homo sapiens	35-42
32242051-3	2021	MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methylation (H3K79me2/3).	Lysine	125-131	AF4/FMR2 family member 1	Homo sapiens	4-7
23725223-1	2013	We calculate the free energy profile for the postulated hydride transfer reaction mechanism for the catalysis of lysine demethylation by lysine-specific demethylase LSD1.	Lysine	113-119	lysine demethylase 1A	Homo sapiens	165-169
23864674-3	2013	The GAD1-TSS(-50kbLoop) was enriched with nucleosomes epigenetically decorated with the transcriptional mark, histone H3 trimethylated at lysine 4, and was weak or absent in skin fibroblasts and pluripotent stem cells compared with neuronal cultures differentiated from them.	Lysine	138-144	glutamate decarboxylase 1	Mus musculus	4-8
23311922-6	2013	EprS preferred to cleave substrates that terminated with arginine or lysine residues.	Lysine	69-75	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	0-4
23424038-8	2013	EZH2 regulates the histone trimethylation of lysine 27 (H3K27me3) in the VDR promoter.	Lysine	45-51	vitamin D receptor	Homo sapiens	73-76
23559091-2	2013	The histone demethylase, lysine (K)-specific demethylase 2A (KDM2A), and the mammalian paralog, lysine (K)-specific demethylase 2B (KDM2B), are evolutionarily conserved and ubiquitously expressed members of the JmjC-domain-containing histone demethylase family.	Lysine	25-31	lysine demethylase 2A	Homo sapiens	61-66
23559091-7	2013	Furthermore, chromatin immunoprecipitation assays demonstrated that silencing of KDM2A increased histone H3 Lysine 4 (H3K4) trimethylation at the p15(INK4B) and p27(Kip1) loci and regulated its expression.	Lysine	108-114	lysine demethylase 2A	Homo sapiens	81-86
23840712-13	2013	Furthermore, replacement of lysine K51, or K117+K122 in 14-3-3beta with glutamine, to mimic lysine acetylation, significantly reduced the interaction between 14-3-3beta and synaptopodin.	Lysine	28-34	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Mus musculus	158-168
23840857-4	2013	Vpu sensitivity is dependent on an alpha helix with a positively charged face containing at least one Lysine.	Lysine	102-108	Vpu	Human immunodeficiency virus 1	0-3
23764001-3	2013	Among several EMT-relevant genes, Sox4 directly regulates the expression of Ezh2, encoding the Polycomb group histone methyltransferase that trimethylates histone 3 lysine 27 (H3K27me3) for gene repression.	Lysine	165-171	SRY-box transcription factor 4	Homo sapiens	34-38
23478035-1	2013	We have developed a nanovector consisting of hyaluronic acid (HA) and poly-L-lysine-graft-imidazole (PLI)-based polyplexes containing Bcl-xL-specific shRNA-encoding plasmid DNA (HA/PLI/pDNA) for CD44 targeted gastric cancer therapy.	Lysine	70-83	serpin family F member 2	Homo sapiens	101-104
23529691-2	2013	Elastin assembles by crosslinking through lysine residues of its monomeric precursor, tropoelastin.	Lysine	42-48	elastin	Homo sapiens	0-7
23529691-2	2013	Elastin assembles by crosslinking through lysine residues of its monomeric precursor, tropoelastin.	Lysine	42-48	elastin	Homo sapiens	86-98
23529691-3	2013	Tropoelastin, as well as polypeptides based on tropoelastin sequences, undergo a process of self-assembly that aligns lysine residues for crosslinking.	Lysine	118-124	elastin	Homo sapiens	0-12
23529691-3	2013	Tropoelastin, as well as polypeptides based on tropoelastin sequences, undergo a process of self-assembly that aligns lysine residues for crosslinking.	Lysine	118-124	elastin	Homo sapiens	47-59
23547809-5	2013	In fact, Tat blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of nuclear factor- kappaB (NF- kappaB) by interacting with the deacetylase domain of SIRT1.	Lysine	56-62	sirtuin 1	Homo sapiens	35-40
23547809-5	2013	In fact, Tat blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of nuclear factor- kappaB (NF- kappaB) by interacting with the deacetylase domain of SIRT1.	Lysine	56-62	sirtuin 1	Homo sapiens	171-176
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	164-170	lysine demethylase 4C	Homo sapiens	100-106
23508685-5	2013	Disruption of 5-HT(2A) receptor-dependent signaling in mice was associated with decreased acetylation of histone H3 (H3ac) and H4 (H4ac) and increased tri-methylation of histone H3 at lysine 27 (H3K27me3) at the mGlu2 promoter, epigenetic changes that correlate with transcriptional repression.	Lysine	184-190	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	14-31
23741347-8	2013	Direct sequencing of his DNA revealed a heterozygous mutation in PRKAG2 consisting of an A-to-G transition at nucleotide 1453 (c.1453A&gt;G), predicting a substitution of a glutamic acid for lysine at highly-conserved residue 485 (p.Lys485Glu, K485E), which was absent in his unaffected family members and in 215 healthy controls.	Lysine	191-197	protein kinase AMP-activated non-catalytic subunit gamma 2	Homo sapiens	65-71
23674823-5	2013	USP25 specifically reversed the Lys(48)-linked ubiquitination of TRAF3 that was mediated by the E3 ubiquitin ligase cIAP2 (cellular inhibitor of apoptosis 2).	Lysine	32-35	TNF receptor-associated factor 3	Mus musculus	65-70
23658800-13	2013	The expression level of caspase 8 was higher in neurons co-treated with lentivirus-shRNA and 5 mmol/L lysine than in control.	Lysine	102-108	caspase 8	Rattus norvegicus	24-33
23658800-14	2013	Benzyloxy-carbonyl-Val-Ala-Asp(OMe)-fluoromethylketone, a pan-caspase inhibitor, blocked the apoptosis induced by lentivirus-shRNA and 5 mmol/L lysine to a great extent.	Lysine	144-150	caspase 8	Rattus norvegicus	62-69
23493288-5	2013	Protection of albumin-lysine residues before exposure to hypochlorous acid as well as regeneration of N-chloramines after oxidation of albumin completely prevented binding of oxidized albumin to SR-BI, indicating that modification of albumin-lysine residues is required to generate SR-BI ligands.	Lysine	242-248	scavenger receptor class B member 1	Homo sapiens	195-200
23402795-4	2013	Using Western blot analysis, we detected global hypoacetylation of histone H3, at lysine residues 9 and 14, and histone H4, at lysine residue 8, in the cortex from juvenile (~24days of age) offspring exposed to polyI:C in utero, but not from adult (3months of age) offspring, which exhibit significant behavioral abnormalities.	Lysine	82-88	H3 clustered histone 7	Mus musculus	67-77
23247248-7	2013	We demonstrate that Pax7 becomes SUMOylated and identify an essential role for lysine 85 (K85) in Pax7-SUMOylation.	Lysine	79-85	paired box 7	Homo sapiens	98-102
23547114-6	2013	Moreover, mechanistic insights acquired by chromatin immunoprecipitation demonstrate that IkappaBzeta is directly recruited to the proximal promoter region of the Ccl2 gene and is required for transcription-enhancing histone H3 at lysine-4 trimethylation.	Lysine	231-237	chemokine (C-C motif) ligand 2	Mus musculus	163-167
23675307-5	2013	This phenotype is linked to increased expression of the histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2), which results in the down-regulation of the tumor suppressors Msmb and Nkx3.1 through increased methylation of lysine 27 of histone H3 (H3K27) on their promoter regions.	Lysine	230-236	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	83-87
23675307-5	2013	This phenotype is linked to increased expression of the histone methyl transferase EZH2 (Enhancer of Zeste Homolog 2), which results in the down-regulation of the tumor suppressors Msmb and Nkx3.1 through increased methylation of lysine 27 of histone H3 (H3K27) on their promoter regions.	Lysine	230-236	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	89-116
23548571-2	2013	Drug-based inhibition of poly(ADP-ribosylation) by a PARP inhibitor, PJ-34, revealed up-regulation of dimethylation of histone H3 at lysine 4 in male pronuclei and down-regulation of dimethylation of histone H3 at lysine 9 (H3K9) and lysine 27 (H3K27).	Lysine	133-139	poly (ADP-ribose) polymerase family, member 1	Mus musculus	53-57
23548571-2	2013	Drug-based inhibition of poly(ADP-ribosylation) by a PARP inhibitor, PJ-34, revealed up-regulation of dimethylation of histone H3 at lysine 4 in male pronuclei and down-regulation of dimethylation of histone H3 at lysine 9 (H3K9) and lysine 27 (H3K27).	Lysine	214-220	poly (ADP-ribose) polymerase family, member 1	Mus musculus	53-57
23548571-2	2013	Drug-based inhibition of poly(ADP-ribosylation) by a PARP inhibitor, PJ-34, revealed up-regulation of dimethylation of histone H3 at lysine 4 in male pronuclei and down-regulation of dimethylation of histone H3 at lysine 9 (H3K9) and lysine 27 (H3K27).	Lysine	214-220	poly (ADP-ribose) polymerase family, member 1	Mus musculus	53-57
23586588-0	2013	Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2 mutant by transcriptional and proteomic analysis.	Lysine	39-45	regulatory protein opaque-2	Zea mays	97-104
23586588-5	2013	These analyses showed that the accumulation of some lysine-rich proteins, such as sorbitol dehydrogenase and glyceraldehyde3-phosphate dehydrogenase, was increased in mature kernels and may contribute substantially to the lysine content of opaque2 endosperm.	Lysine	52-58	regulatory protein opaque-2	Zea mays	240-247
23586588-8	2013	CONCLUSIONS: The results of these studies revealed specific target genes that can be investigated to further improve nutritional quality and agronomic performance of high lysine maize lines, particularly those based on the presence of the opaque2 mutation.	Lysine	171-177	regulatory protein opaque-2	Zea mays	239-246
23396334-8	2013	Applying our findings, we optimized l-lysine production in the model strain C. glutamicum DM1729 by deletion of pgi and overexpression of plasmid-encoded ptsG.	Lysine	36-44	glucose-6-phosphate isomerase	Corynebacterium glutamicum ATCC 13032	112-115
23396334-10	2013	These results show that ptsG overexpression is required to overcome the repressed activity of PTS-mediated glucose uptake in pgi-deficient C. glutamicum strains, thus enabling efficient as well as fast l-lysine production.	Lysine	202-210	glucose-6-phosphate isomerase	Corynebacterium glutamicum ATCC 13032	125-128
23460739-10	2013	In conclusion, we show that ficolins are new CR1 ligands and propose that MBL/L-ficolin binding involves major ionic interactions between conserved lysine residues of their collagen stalks and surface exposed acidic residues located in CR1 CCP24 and/or CCP25.	Lysine	148-154	ficolin 2	Homo sapiens	78-87
23401858-7	2013	Histone H3 K9 was found to be the important lysine that is acetylated by Rtt109 during ctk1-dependent cryptic transcription.	Lysine	44-50	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	73-79
23401858-7	2013	Histone H3 K9 was found to be the important lysine that is acetylated by Rtt109 during ctk1-dependent cryptic transcription.	Lysine	44-50	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	87-91
23455478-5	2013	CUL3-KLHL22 ubiquitylates Lys 492, located within the PBD, leading to PLK1 dissociation from kinetochore phosphoreceptors.	Lysine	26-29	polo like kinase 1	Homo sapiens	70-74
22614015-5	2013	Furthermore, HACE1 catalyses the poly-ubiquitylation of Rac1 at lysine 147 following its activation by HGF, resulting in its proteasomal degradation.	Lysine	64-70	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Homo sapiens	13-18
22614015-5	2013	Furthermore, HACE1 catalyses the poly-ubiquitylation of Rac1 at lysine 147 following its activation by HGF, resulting in its proteasomal degradation.	Lysine	64-70	Rac family small GTPase 1	Homo sapiens	56-60
23395003-1	2013	Polycomb repressive complex 1 (PRC1) catalyzes lysine 119 monoubiquitylation on H2A (H2AK119ub1) and regulates pluripotency in embryonic stem cells (ESCs).	Lysine	47-53	chromobox 2	Mus musculus	0-8
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	61-64	dishevelled segment polarity protein 2 L homeolog	Xenopus laevis	53-57
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	dishevelled segment polarity protein 2 L homeolog	Xenopus laevis	53-57
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	dishevelled segment polarity protein 2 L homeolog	Xenopus laevis	53-57
23396981-6	2013	Interestingly, the NEDD4L-mediated ubiquitination of Dvl2 is Lys-6, Lys-27, and Lys-29 linked but not typical Lys-48-linked ubiquitination.	Lysine	68-71	dishevelled segment polarity protein 2 L homeolog	Xenopus laevis	53-57
23404370-6	2013	All KLF4 mutations were identical, affected codon 409 and resulted in a lysine to glutamine exchange (K409Q).	Lysine	72-78	Kruppel like factor 4	Homo sapiens	4-8
23352453-6	2013	MTA1"s lysine 532 methylation represents a molecular switch as methylated and demethylated MTA1 nucleate NuRD or NURF complexes with opposite functions in a cyclical manner.	Lysine	7-13	metastasis associated 1	Homo sapiens	0-4
23352453-6	2013	MTA1"s lysine 532 methylation represents a molecular switch as methylated and demethylated MTA1 nucleate NuRD or NURF complexes with opposite functions in a cyclical manner.	Lysine	7-13	metastasis associated 1	Homo sapiens	91-95
23353890-7	2013	Furthermore, mutation of the Godzilla ubiquitylation target lysines on VAMP3 abrogates the formation of enlarged endosomes induced by either Godzilla or RNF167.	Lysine	60-67	ring finger protein 167	Homo sapiens	153-159
23228886-7	2013	When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive.	Lysine	83-89	neurofilament light chain	Homo sapiens	17-21
23378224-4	2013	The TPM2 p.K7del mutation results in the loss of a highly conserved lysine residue near the N-terminus of beta-tropomyosin, which is predicted to disrupt head-to-tail polymerization of tropomyosin.	Lysine	68-74	tropomyosin 2	Homo sapiens	4-8
23413262-0	2013	Novel deletion of lysine 7 expands the clinical, histopathological and genetic spectrum of TPM2-related myopathies.	Lysine	18-24	tropomyosin 2 (beta)	Danio rerio	91-95
23324626-0	2013	SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.	Lysine	29-35	SET domain containing 6	Mus musculus	0-5
23414320-0	2013	Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines.	Lysine	8-14	histone deacetylase 9	Homo sapiens	97-101
23197473-3	2013	Methylation of histone H3 at lysine 4 (H3K4me), which is associated with transcriptional activation, requires several cofactors, including Ash2.	Lysine	29-35	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	139-143
23650795-10	2013	Findings of the light microscope and electron microscope showed that the injury severity of pyramidal cells of hippocampal CA 1 and CA 3 regions was moderate 4 h after epileptic seizure and even worse 24 h after seizure in the model group, LY 294002 group and acupuncture+ LY 294002 group, but relatively lighter in the acupuncture group.	Lysine	240-242	carbonic anhydrase 3	Rattus norvegicus	132-136
23650795-10	2013	Findings of the light microscope and electron microscope showed that the injury severity of pyramidal cells of hippocampal CA 1 and CA 3 regions was moderate 4 h after epileptic seizure and even worse 24 h after seizure in the model group, LY 294002 group and acupuncture+ LY 294002 group, but relatively lighter in the acupuncture group.	Lysine	273-275	carbonic anhydrase 3	Rattus norvegicus	132-136
23161542-0	2013	Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein.	Lysine	76-82	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	159-164
23161542-3	2013	Recent studies have shown that the plant homeodomain (PHD) of UHRF1 recognizes the N terminus of unmodified histone H3, and the interaction is inhibited by methylation of H3R2, whereas the tandem tudor domain (TTD) of UHRF1 recognizes trimethylated histone H3 lysine 9 (H3K9me3).	Lysine	260-266	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	62-67
23614352-1	2013	EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27).	Lysine	116-122	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
23534753-4	2013	Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes.	Lysine	297-300	X-ray repair cross complementing 1	Homo sapiens	23-28
24200777-0	2013	Induction by fructose force-feeding of histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and its expression in mice.	Lysine	78-84	solute carrier family 2 (facilitated glucose transporter), member 5	Mus musculus	105-111
24200777-2	2013	We demonstrate in this study that acetylation at lysine (K) 9 of histone H3 and acetylation at K5 and K16 of histone H4 were more enhanced in the promoter/enhancer to transcribed regions of the Slc2a5 gene in fructose force-fed mice than in glucose force-fed mice.	Lysine	49-55	solute carrier family 2 (facilitated glucose transporter), member 5	Mus musculus	194-200
23439558-5	2013	Moreover, although the Gfap promoter region containing the STAT3-binding site (GSBS) is enriched with transcription-repressive histone modifications, such as methylation of H3 at lysine 9 (H3K9me3) and H3K27me3, the reduction of these modifications in TKO ESCs was not sufficient for binding of STAT3 at GSBS.	Lysine	179-185	protein phosphatase 1, regulatory subunit 17	Mus musculus	79-83
23257913-1	2013	Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is mostly associated with transcriptional repression.	Lysine	0-6	euchromatic histone lysine methyltransferase 2	Homo sapiens	82-85
24070470-4	2013	Sequential reactions by the E1 enzyme Atg7 and the E2 enzyme Atg10 conjugate Atg12 to the lysine residue in Atg5, and the resulting Atg12-Atg5 conjugate forms a complex with Atg16.	Lysine	90-96	autophagy related 10	Homo sapiens	61-66
23662713-2	2013	It was shown in system modeling that Maillard reaction interaction of L-lysine (L-lys) with methylglyoxal (MG) led to the formation of compounds reducing methemoglobin (metHb).	Lysine	70-78	hemoglobin subunit gamma 2	Homo sapiens	154-167
23662713-2	2013	It was shown in system modeling that Maillard reaction interaction of L-lysine (L-lys) with methylglyoxal (MG) led to the formation of compounds reducing methemoglobin (metHb).	Lysine	70-78	hemoglobin subunit gamma 2	Homo sapiens	169-174
23662713-2	2013	It was shown in system modeling that Maillard reaction interaction of L-lysine (L-lys) with methylglyoxal (MG) led to the formation of compounds reducing methemoglobin (metHb).	Lysine	70-75	hemoglobin subunit gamma 2	Homo sapiens	154-167
23662713-2	2013	It was shown in system modeling that Maillard reaction interaction of L-lysine (L-lys) with methylglyoxal (MG) led to the formation of compounds reducing methemoglobin (metHb).	Lysine	70-75	hemoglobin subunit gamma 2	Homo sapiens	169-174
23662713-6	2013	It was also shown that the yield of organic free-radical intermediates of the L-lys with MG was increased in the presence of GSNO and metHb.	Lysine	78-83	hemoglobin subunit gamma 2	Homo sapiens	134-139
22949511-0	2013	Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen.	Lysine	141-148	FKBP prolyl isomerase 10	Homo sapiens	13-19
23147254-3	2013	Here we discuss new evidence for a BAP1-independent function of ASXL1 in regulating histone H3 lysine 27 methylation through interactions with the Polycomb-repressive complex 2 (PRC2).	Lysine	95-101	ASXL transcriptional regulator 1	Homo sapiens	64-69
23874194-1	2013	Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	31-35
23874194-1	2013	Lysine specific demethylase-1 (LSD1/KDM1A) in complex with its corepressor protein CoREST is a promising target for epigenetic drugs.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	36-41
23349634-6	2013	Based on the spectral data, we were able to identify methylation sites in substrates, notably trimethylation of K135 of KIN/Kin17, K561 of HSPA8/Hsc70 as well as corresponding lysine residues in other Hsp70 isoforms, and K315 of VCP/p97.	Lysine	176-182	heat shock protein family A (Hsp70) member 8	Homo sapiens	201-206
23418492-11	2013	CONCLUSIONS/SIGNIFICANCE: Results are consistent with a regulatory role of lysine acetylation on PSG expression through a relaxed chromatin state and an increase in the transcriptional activity of Sp1 and KLF6 following an augmented Sp1 acetylation and KLF6 nuclear localization.	Lysine	75-81	Kruppel like factor 6	Homo sapiens	205-209
23418492-11	2013	CONCLUSIONS/SIGNIFICANCE: Results are consistent with a regulatory role of lysine acetylation on PSG expression through a relaxed chromatin state and an increase in the transcriptional activity of Sp1 and KLF6 following an augmented Sp1 acetylation and KLF6 nuclear localization.	Lysine	75-81	Kruppel like factor 6	Homo sapiens	253-257
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	inhibitor of kappaB kinase gamma	Mus musculus	111-139
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	inhibitor of kappaB kinase gamma	Mus musculus	141-145
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	inhibitor of kappaB kinase gamma	Mus musculus	146-154
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	inhibitor of kappaB kinase gamma	Mus musculus	206-210
23825957-7	2013	Mechanistically, the small ubiquitin-like modifier 2/3 (SUMO-2/3) is conjugated onto the Lysine residue 277 of NF-kappaB essential modifier (NEMO/IKKgamma), and this impairs the deubiquitinase CYLD to bind NEMO, thus strengthening the inhibitor of kappaB kinase (IKK) activation.	Lysine	89-95	inhibitor of kappaB kinase gamma	Mus musculus	146-149
23201684-7	2012	Using gain- and loss-of-function mutants, we demonstrate that acetylation of RIP1 lysine 530 modulates RIP1-RIP3 complex formation and TNF-alpha-stimulated necrosis.	Lysine	82-88	receptor-interacting serine-threonine kinase 3	Mus musculus	108-112
23051747-2	2012	EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27).	Lysine	157-163	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
32480855-1	2012	In Arabidopsis thalinana (L.) Heynh., DHDPS1 and DHDPS2 encode orthologous dihydrodipicolinate synthases (DHDPS), the first enzyme of the lysine (Lys) biosynthesis pathway.	Lysine	138-144	dihydrodipicolinate synthase	Arabidopsis thaliana	49-55
32480855-1	2012	In Arabidopsis thalinana (L.) Heynh., DHDPS1 and DHDPS2 encode orthologous dihydrodipicolinate synthases (DHDPS), the first enzyme of the lysine (Lys) biosynthesis pathway.	Lysine	146-149	dihydrodipicolinate synthase	Arabidopsis thaliana	49-55
32480855-6	2012	dhdps1-dhdps2 double mutants could not be isolated, even after exogenous feeding with Lys.	Lysine	86-89	dihydrodipicolinate synthase	Arabidopsis thaliana	7-13
32480855-8	2012	Plants carrying only a single DHDPS2 gene do not accumulate Thr, but they show a gametophytic defect that is partially rescued by Lys application.	Lysine	130-133	dihydrodipicolinate synthase	Arabidopsis thaliana	30-36
32480855-11	2012	Exogenous application of Lys and methionine to dhdps2 mutants did not reduce the accumulation of Thr.	Lysine	25-28	dihydrodipicolinate synthase	Arabidopsis thaliana	47-53
23058792-1	2012	The objective was to investigate the relationship between histone H3 lysine 9 (H3K9) dimethylation (me2) and the histone methyltransferase EHMT2 (also known as G9A) in ovine embryos cloned by somatic cell nuclear transfer (SCNT).	Lysine	69-75	histone-lysine N-methyltransferase EHMT2	Ovis aries	139-144
23136435-4	2012	Using molecular dynamic simulations of membrane-embedded SybII, we show that Trp residues of the JMD influence the electrostatic surface potential by controlling the position of neighboring lysine and arginine residues at the membrane-water interface.	Lysine	190-196	vesicle-associated membrane protein 2	Mus musculus	57-62
23110252-1	2012	Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2.	Lysine	147-153	AE binding protein 2	Homo sapiens	212-217
22902619-6	2012	Furthermore, Lys-30 is identified as a ubiquitination site of SLP-76.	Lysine	13-16	lymphocyte cytosolic protein 2	Homo sapiens	62-68
22902619-7	2012	Loss of Lys-30 ubiquitination of SLP-76 results in enhanced anti-CD3 antibody-induced ERK and JNK activation.	Lysine	8-11	lymphocyte cytosolic protein 2	Homo sapiens	33-39
22743349-2	2012	Although CaMKP is known to be activated by phosphorylation with CaMKII and stimulated by the addition of polycations such as poly-l-lysine, detailed mechanisms of regulation of CaMKP in vivo still remain unclear.	Lysine	125-138	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	9-14
22935713-5	2012	ORCA utilizes lysine-48 (K48) ubiquitin linkage, suggesting that ORCA ubiquitination mediates its regulated degradation.	Lysine	14-20	leucine rich repeats and WD repeat domain containing 1	Homo sapiens	0-4
22935713-5	2012	ORCA utilizes lysine-48 (K48) ubiquitin linkage, suggesting that ORCA ubiquitination mediates its regulated degradation.	Lysine	14-20	leucine rich repeats and WD repeat domain containing 1	Homo sapiens	65-69
32605929-4	2021	All three JMJD1 proteins are capable of removing di- and monomethyl marks from lysine 9 on histone H3 and might also demethylate histone H4 on arginine 3 and non-histone proteins.	Lysine	79-85	lysine (K)-specific demethylase 3A	Mus musculus	10-15
32605929-9	2021	Notably, by reducing methylation levels on histone H3 lysine 9, JMJD1 proteins can profoundly alter the transcriptome and thereby affect tumorigenesis, including through upregulating oncogenes such as CCND1, JUN and MYC.	Lysine	54-60	lysine (K)-specific demethylase 3A	Mus musculus	64-69
32605929-9	2021	Notably, by reducing methylation levels on histone H3 lysine 9, JMJD1 proteins can profoundly alter the transcriptome and thereby affect tumorigenesis, including through upregulating oncogenes such as CCND1, JUN and MYC.	Lysine	54-60	cyclin D1	Mus musculus	201-206
33456583-11	2021	Notably, the lysine 64 residue on SHMT2 (SHMT2K64) mediated its interaction with beta-catenin.	Lysine	13-19	serine hydroxymethyltransferase 2	Homo sapiens	34-39
33456583-11	2021	Notably, the lysine 64 residue on SHMT2 (SHMT2K64) mediated its interaction with beta-catenin.	Lysine	13-19	serine hydroxymethyltransferase 2	Homo sapiens	41-49
33326781-4	2020	DOT1L-dependent dimethylation of lysine 79 of histone H3 (H3K79me2) is associated with lineage-specific gene expression.	Lysine	33-39	H3 clustered histone 7	Mus musculus	46-56
33257578-6	2020	In this model, SPINDOC interacts with the SPIN1 interface previously shown to bind a lysine and arginine methylated sequence of histone H3.	Lysine	85-91	spindlin 1	Homo sapiens	42-47
33322233-8	2020	Both global and local levels on the Wnt6 promoter region of histone H3 lysine 4 trimethylation, an active transcriptional histone marker, increased markedly by MAOC treatment in 3T3-L1 cells.	Lysine	71-77	wingless-type MMTV integration site family, member 6	Mus musculus	36-40
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	snail family transcriptional repressor 2	Homo sapiens	164-168
33291558-9	2020	CONCLUSIONS: The results suggest that certain histone lysine methyltransferase/demethylase, such as MLL4, UTX, and EZH2, regulate the expression of EMT-TFs such as Slug, ZEB1, and Twist epigenetically, which may thereby influence cancer metastasis from the lung to the brain.	Lysine	54-60	zinc finger E-box binding homeobox 1	Homo sapiens	170-174
33938178-0	2021	Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.	Lysine	0-6	lysine acetyltransferase 5	Homo sapiens	25-30
23050233-2	2012	The most well-defined targets for Esa1 are lysine residues on histones.	Lysine	43-49	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	34-38
21642861-10	2011	Furthermore, c-myc down-regulation and apoptotic cell death coinduced by IR and HDACI were suppressed in cells transfected with mutant K382R p53 and C135Y p53 displaying loss of acetylation at lysine 382 and DNA-binding activity, respectively.	Lysine	193-199	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
22797925-8	2012	p62 becomes covalently mono-FAT10ylated at several lysines, and FAT10 colocalizes with p62 in p62 bodies.	Lysine	51-58	sequestosome 1	Homo sapiens	0-3
22797925-8	2012	p62 becomes covalently mono-FAT10ylated at several lysines, and FAT10 colocalizes with p62 in p62 bodies.	Lysine	51-58	sequestosome 1	Homo sapiens	87-90
22797925-8	2012	p62 becomes covalently mono-FAT10ylated at several lysines, and FAT10 colocalizes with p62 in p62 bodies.	Lysine	51-58	sequestosome 1	Homo sapiens	87-90
33938178-0	2021	Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.	Lysine	0-6	amyloid beta precursor protein binding family B member 1	Homo sapiens	58-62
33938178-2	2021	Bound to the APP adaptor protein Fe65 and the lysine acetyltransferase (KAT) Tip60, AICD translocates to the nucleus.	Lysine	46-52	lysine acetyltransferase 5	Homo sapiens	77-82
21703230-3	2011	Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells.	Lysine	10-16	GATA binding protein 3	Mus musculus	53-58
33938178-6	2021	We identify lysine residues 204 and 701 of Fe65 as acetylation targets of Tip60.	Lysine	12-18	amyloid beta precursor protein binding family B member 1	Homo sapiens	43-47
33938178-6	2021	We identify lysine residues 204 and 701 of Fe65 as acetylation targets of Tip60.	Lysine	12-18	lysine acetyltransferase 5	Homo sapiens	74-79
33938178-10	2021	A second acetylation/deacetylation cycle, conducted by CBP and class I/II KDACs at different lysine residues, regulates stability of Fe65.	Lysine	93-99	amyloid beta precursor protein binding family B member 1	Homo sapiens	133-137
33077425-4	2020	An epigenetic modifier, a histone methyl transferase enzyme G9a, known to increase histone 3 lysine 9 (H3K9) methylation, is down regulated in diet induced obesity animal models.	Lysine	93-99	euchromatic histone lysine methyltransferase 2	Homo sapiens	60-63
22851697-2	2012	Recently, JMJD5 (also called KDM8) has been reported to demethylate dimethylated Lys-36 in histone H3 (H3K36me2), regulating genes that control cell cycle progression.	Lysine	81-84	lysine demethylase 8	Homo sapiens	10-15
22851697-2	2012	Recently, JMJD5 (also called KDM8) has been reported to demethylate dimethylated Lys-36 in histone H3 (H3K36me2), regulating genes that control cell cycle progression.	Lysine	81-84	lysine demethylase 8	Homo sapiens	29-33
22961379-4	2012	Proper AGO1 and AGO2 recruitment to CD44 transcribed regions required the endonuclease Dicer and the chromobox protein HP1gamma, and resulted in increased histone H3 lysine 9 methylation on variant exons.	Lysine	166-172	CD44 molecule (Indian blood group)	Homo sapiens	36-40
21527745-8	2011	Moreover, the mutation of more than 17 predicted and conserved lysine residues on Nox5 did not alter the inhibitory actions of SUMO1.	Lysine	63-69	NADPH oxidase 5	Homo sapiens	82-86
33123246-7	2020	Consistent with this finding, the removal of the repressive transcription marker, dimethylated histone H3 at lysine 9 from the Slug promoter is dependent on hypoxia-induced recruitment of KDM3A.	Lysine	109-115	snail family transcriptional repressor 2	Homo sapiens	127-131
33123246-7	2020	Consistent with this finding, the removal of the repressive transcription marker, dimethylated histone H3 at lysine 9 from the Slug promoter is dependent on hypoxia-induced recruitment of KDM3A.	Lysine	109-115	lysine demethylase 3A	Homo sapiens	188-193
22967896-4	2012	These data indicate that human Amphiregulin is cleaved at Lysine 187, a site homologous to the cleavage site reported in the mouse protein and distinct from the Lysine 184 site previously reported for the human protein.	Lysine	58-64	amphiregulin	Homo sapiens	31-43
21670282-0	2011	Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.	Lysine	32-38	WNK lysine deficient protein kinase 4	Homo sapiens	42-46
22967896-4	2012	These data indicate that human Amphiregulin is cleaved at Lysine 187, a site homologous to the cleavage site reported in the mouse protein and distinct from the Lysine 184 site previously reported for the human protein.	Lysine	161-167	amphiregulin	Homo sapiens	31-43
32436613-3	2020	Here, we characterized a novel naturally occurring maize mdh4-1 mutant, which produces small, opaque kernels and exhibits reduced starch but enhanced lysine content.	Lysine	150-156	malate dehydrogenase, cytoplasmic	Zea mays	57-61
22914091-0	2012	Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.	Lysine	31-37	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-4
21700219-3	2011	Here we show that PKM2 is acetylated on lysine 305 and that this acetylation is stimulated by high glucose concentration.	Lysine	40-46	pyruvate kinase M1/2	Homo sapiens	18-22
22914091-1	2012	Set2-mediated methylation of histone H3 at Lys 36 (H3K36me) is a co-transcriptional event that is necessary for the activation of the Rpd3S histone deacetylase complex, thereby maintaining the coding region of genes in a hypoacetylated state.	Lysine	43-46	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-4
22052438-6	2012	Cryptotanshinone increased the mono-methyl and di-methylation of Histone H3 lysine 9 (H3K9), a repressive histone marker which is demethylated and activated by LSD1.	Lysine	76-82	lysine demethylase 1A	Homo sapiens	160-164
33257809-3	2020	Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27 di-methylation of histone H3 (H3K9me2, H3K27me2) and participates in the transcriptional activation of developmental genes.	Lysine	0-6	lysine (K)-specific demethylase 7A	Mus musculus	23-28
33257809-3	2020	Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27 di-methylation of histone H3 (H3K9me2, H3K27me2) and participates in the transcriptional activation of developmental genes.	Lysine	43-49	lysine (K)-specific demethylase 7A	Mus musculus	23-28
33330479-3	2020	The histone lysine methyltransferase G9a is mainly responsible for the mono- and di-methylation of histone H3 lysine 9 (H3K9), whose overexpression is associated with a more aggressive phenotype in cancer.	Lysine	12-18	euchromatic histone lysine methyltransferase 2	Homo sapiens	37-40
21463634-2	2011	Conjugation of the ubiquitin-like molecule Nedd8 to a conserved lysine residue on the cullin scaffold is essential for the activity of CRLs.	Lysine	64-70	CDK2 associated cullin domain 1	Homo sapiens	86-92
33058874-5	2020	Succinylation and ubiquitination of fumarase at lysines 78 and 79, phosphorylation at threonine 122, serine 124 and threonine 126 as well as deamidation at arginine 239 were found to be functionally relevant.	Lysine	48-55	fumarate hydratase	Homo sapiens	36-44
22829592-8	2012	These results demonstrate that Fe(2+)-generated O(2)() mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in HM.	Lysine	116-119	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	77-81
22829592-8	2012	These results demonstrate that Fe(2+)-generated O(2)() mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in HM.	Lysine	116-119	TNF receptor associated factor 6	Rattus norvegicus	134-139
22943296-5	2012	Further, the residues Lys 18, Thr 20, Ala 21, Val 22, Phe 46, Glu 48, Lys 50, Lys 58, Thr 75, Gln 77, Arg 97 and Ile 98 form hot point motif, which on interaction enhances BDNF"s function.	Lysine	22-25	brain derived neurotrophic factor	Homo sapiens	172-176
22943296-5	2012	Further, the residues Lys 18, Thr 20, Ala 21, Val 22, Phe 46, Glu 48, Lys 50, Lys 58, Thr 75, Gln 77, Arg 97 and Ile 98 form hot point motif, which on interaction enhances BDNF"s function.	Lysine	70-73	brain derived neurotrophic factor	Homo sapiens	172-176
22943296-5	2012	Further, the residues Lys 18, Thr 20, Ala 21, Val 22, Phe 46, Glu 48, Lys 50, Lys 58, Thr 75, Gln 77, Arg 97 and Ile 98 form hot point motif, which on interaction enhances BDNF"s function.	Lysine	70-73	brain derived neurotrophic factor	Homo sapiens	172-176
32822681-4	2020	Using this assay, we demonstrated that the lysine residue K131 in the effector domain of NS1 is a previously unidentified SUMO acceptor site.	Lysine	43-49	influenza virus NS1A binding protein	Homo sapiens	89-92
21444715-4	2011	Our molecular modeling and mutagenic analysis also indicate that Gwl displays a conserved tail/linker site whose phosphorylation mediates kinase activation by promoting the interaction of this phosphorylated residue with two lysines at the N terminus.	Lysine	225-232	microtubule associated serine/threonine kinase like	Homo sapiens	65-68
22914824-9	2012	The results of the study thus revealed an inhibition by lysine at position 222 on the binding of mAb F99/97.6.1 to goat PrP.	Lysine	56-62	major prion protein	Capra hircus	120-123
21551099-2	2011	Using this compendium, we focused on a well-known repressive mark, histone H3 lysine 27 trimethylation, and identified novel regulatory elements flanking the myogenin gene that function as a key differentiation-dependent switch during myogenesis.	Lysine	78-84	myogenin	Mus musculus	158-166
23028367-3	2012	Among other biological processes, lysine deacetylation, through the Rpd3L, Rpd3S, and Hda1 complexes, emerged as being a critical regulator of telomere structure.	Lysine	34-40	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	86-90
22923582-0	2012	Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.	Lysine	71-77	chromobox 2	Mus musculus	26-34
33152999-1	2020	Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase that acetylates the C5 position of wobble-base uridines (U34) in transfer RNAs (tRNAs).	Lysine	70-76	elongator acetyltransferase complex subunit 3	Homo sapiens	0-4
32684241-1	2020	Dimethylation of the histone H3 protein at lysine residue 9 (H3K9) is mediated by euchromatin histone methyltransferase II (EHMT2) and results in transcriptional repression of target genes.	Lysine	43-49	euchromatic histone lysine methyltransferase 2	Homo sapiens	124-129
21739721-0	2011	An acetylation-mono-ubiquitination switch on lysine 120 of H2B.	Lysine	45-51	H2B clustered histone 21	Homo sapiens	59-62
22923582-1	2012	Polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) methylation is vital for Polycomb gene silencing, a classic epigenetic phenomenon that maintains transcriptional silencing throughout cell divisions.	Lysine	57-63	chromobox 2	Mus musculus	0-8
22923582-1	2012	Polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) methylation is vital for Polycomb gene silencing, a classic epigenetic phenomenon that maintains transcriptional silencing throughout cell divisions.	Lysine	57-63	chromobox 2	Mus musculus	100-108
31092054-2	2020	Jumonji domain-containing 3 (Jmjd3), also known as KDM6B, is a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3) that specifically removes the methylation of H3K27me3 and promotes gene expression.	Lysine	125-131	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	0-27
21739721-3	2011	Lysine 120 of H2B is modified by two PTMs: ubiquitination, which is required for further trans-tail H3 methylations and elongation, and acetylation, whose role is less clear.	Lysine	0-6	H2B clustered histone 21	Homo sapiens	14-17
31092054-2	2020	Jumonji domain-containing 3 (Jmjd3), also known as KDM6B, is a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3) that specifically removes the methylation of H3K27me3 and promotes gene expression.	Lysine	125-131	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	29-34
31092054-2	2020	Jumonji domain-containing 3 (Jmjd3), also known as KDM6B, is a specific histone demethylase for trimethylation on histone H3 lysine 27 (H3K27me3) that specifically removes the methylation of H3K27me3 and promotes gene expression.	Lysine	125-131	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	51-56
22120716-2	2012	We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation.	Lysine	92-99	notch 3	Mus musculus	46-52
22120716-2	2012	We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation.	Lysine	92-99	E1A binding protein p300	Mus musculus	117-121
21739721-9	2011	Our data point at acetylation of Lysine 120 of H2B as an early mark of poised or active state and establish a temporal sequence between acetylation and mono-ubiquitination of this H2B residue.	Lysine	33-39	H2B clustered histone 21	Homo sapiens	47-50
21306436-4	2011	Formation of this complex was blocked by a mutation of the glycosaminoglycan-binding basic cluster (Lys(23) -Lys(29) ) in RP S19.	Lysine	100-103	ribosomal protein S19	Homo sapiens	122-128
22677129-1	2012	EZH2, a catalytic component of the polycomb repressive complex 2, trimethylates histone H3 at lysine 27 (H3K27) to repress the transcription of target genes.	Lysine	94-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
22020899-6	2012	Importantly, we found that KDM3A activates transcription of the HOXA1 gene through demethylating histone H3 at lysine 9 di-methylation by binding to its promoter region.	Lysine	111-117	lysine demethylase 3A	Homo sapiens	27-32
33155839-1	2020	The Tip60 lysine acetyltransferase is a tumor suppressor in most cancers but an oncogene in prostate and gastric cancer.	Lysine	10-16	lysine acetyltransferase 5	Homo sapiens	4-9
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	TOX high mobility group box family member 2	Homo sapiens	119-123
33169618-4	2020	Histone 3 lysine 9 trimethylation was downregulated and histone 3 lysine 4 trimethylation was upregulated in PD-L1 and TOX2 promoters in tumor tissues, suggesting that PD-L1 and TOX2 upregulation in CRC tumors could be mediated by activating histone 3 lysine 4 trimethylation.	Lysine	66-72	TOX high mobility group box family member 2	Homo sapiens	119-123
21306436-4	2011	Formation of this complex was blocked by a mutation of the glycosaminoglycan-binding basic cluster (Lys(23) -Lys(29) ) in RP S19.	Lysine	109-112	ribosomal protein S19	Homo sapiens	122-128
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Lysine	80-83	aspartate kinase	Saccharomyces cerevisiae S288C	133-135
32569093-6	2020	CRMP2, modified at Lysine 374 (K374) by addition of a small ubiquitin-like modifier (SUMO), bound NaV1.7 to regulate its membrane localization and function.	Lysine	19-25	sodium voltage-gated channel alpha subunit 9	Homo sapiens	98-104
32888909-8	2020	Noteworthy, most modifications were observed at Lys and His residues located at A-site (K73, K87, K88), L-site (H26, H33, and K27) membrane binding sites.	Lysine	48-51	keratin 73	Homo sapiens	88-91
22896734-0	2012	Effects of porcine somatotropin administration on the responses to dietary lysine and a near-ideal blend of amino acids for growing pigs.	Lysine	75-81	somatotropin	Sus scrofa	19-31
22582844-8	2012	Cathepsin H shows highest activities for cleaving N-terminal basic residues (Arg and Lys) among amino acid fluorogenic substrates.	Lysine	85-88	cathepsin H	Mus musculus	0-11
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Lysine	80-83	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Lysine	80-83	aspartate kinase	Saccharomyces cerevisiae S288C	169-185
22472464-4	2012	This is due to aberrant gene silencing by the trimethylation of histone H3 lysine 27 (H3K27me3) by EZH2.	Lysine	75-81	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	99-103
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Lysine	80-83	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21625535-7	2011	MARCH5 catalyzes the K63-linked poly-ubiquitination of TANK on its Lysines 229, 233, 280, 302 and 306, thus impairing the ability of TANK to inhibit TRAF6.	Lysine	67-74	membrane associated ring-CH-type finger 5	Homo sapiens	0-6
22645302-6	2012	Acetylated lysine 27 of histone 3 covered the HIF1 binding sites, and HIF1 functioned as an enhancer of SLC2A3 by interaction with lysine (K)-specific demethylase 3A (KDM3A).	Lysine	131-137	solute carrier family 2 member 3	Homo sapiens	104-110
22645302-6	2012	Acetylated lysine 27 of histone 3 covered the HIF1 binding sites, and HIF1 functioned as an enhancer of SLC2A3 by interaction with lysine (K)-specific demethylase 3A (KDM3A).	Lysine	131-137	lysine demethylase 3A	Homo sapiens	167-172
21423168-8	2011	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	Lysine	114-120	lysine methyltransferase 2A	Homo sapiens	68-71
32969463-2	2020	HEMK2-TRMT112 heterodimer has been reported to be responsible for both histone lysine methylation and eukaryotic release factor 1 (eRF1) glutamine methylation.	Lysine	79-85	N-6 adenine-specific DNA methyltransferase 1	Homo sapiens	0-5
21165646-2	2011	AtAGP17, 18 and 19 comprise the lysine-rich classical AGP subfamily in Arabidopsis.	Lysine	32-38	arabinogalactan protein 17	Arabidopsis thaliana	0-7
32969463-2	2020	HEMK2-TRMT112 heterodimer has been reported to be responsible for both histone lysine methylation and eukaryotic release factor 1 (eRF1) glutamine methylation.	Lysine	79-85	tRNA methyltransferase activator subunit 11-2	Homo sapiens	6-13
32969463-6	2020	Therefore, our work not only throws light on the protein glutamine methylation mechanism, but also reveals the dual activity of HEMK2 by catalyzing the methylation of both Lys and Gln residues.	Lysine	172-175	N-6 adenine-specific DNA methyltransferase 1	Homo sapiens	128-133
22659026-3	2012	Analysis of two selected neuroprotective genes, iNOS and HIF-1alpha, showed marked increase in lysine 4 di-methylation and decrease in lysine 9 di-methylation of H3 histone.	Lysine	95-101	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-67
22659026-3	2012	Analysis of two selected neuroprotective genes, iNOS and HIF-1alpha, showed marked increase in lysine 4 di-methylation and decrease in lysine 9 di-methylation of H3 histone.	Lysine	135-141	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	57-67
32768649-5	2020	Inhibition assays enabled the identification of a >200-fold selective MMP9 inhibitor when Lys was considered as a C-4 substituent, thus addressing gelatinase selectivity beyond the S1" subsite, which is a major driver for selectivity.	Lysine	90-93	matrix metallopeptidase 9	Homo sapiens	70-74
21047549-3	2011	Chromatin immunoprecipitation revealed that the increase in beta(2)AR gene expression in T(H)1 cells is mediated by an increase in histone 3 (H3) and H4 acetylation, as well as an increase in histone 3 lysine 4 (H3K4) methylation.	Lysine	202-208	adrenergic receptor, beta 2	Mus musculus	60-69
32768649-6	2020	Molecular docking studies revealed the basic moiety of Lys as detrimental for inhibition of MMP2 as compared to MMP9.	Lysine	55-58	matrix metallopeptidase 9	Homo sapiens	112-116
32855205-4	2020	Screening of five human chordoma cell lines revealed that pharmacologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) leads to cell death.	Lysine	100-106	lysine demethylase 6B	Homo sapiens	139-144
32855205-4	2020	Screening of five human chordoma cell lines revealed that pharmacologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) leads to cell death.	Lysine	100-106	lysine demethylase 6B	Homo sapiens	146-151
24970141-2	2012	Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins.	Lysine	47-53	Ribosomal protein S27A	Drosophila melanogaster	5-14
24970141-2	2012	Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins.	Lysine	47-53	smt3	Drosophila melanogaster	16-20
22536950-3	2012	G9a (also named euchromatin histone methyltransferase 2 (EHMT2)) catalyzes methylation of lysine 9 on histone H3 (H3K9), a modification linked to aberrant silencing of tumor-suppressor genes, among others.	Lysine	90-96	euchromatic histone lysine methyltransferase 2	Homo sapiens	16-55
22536950-3	2012	G9a (also named euchromatin histone methyltransferase 2 (EHMT2)) catalyzes methylation of lysine 9 on histone H3 (H3K9), a modification linked to aberrant silencing of tumor-suppressor genes, among others.	Lysine	90-96	euchromatic histone lysine methyltransferase 2	Homo sapiens	57-62
20885444-0	2011	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.	Lysine	28-34	BCL2-antagonist/killer 1	Mus musculus	99-102
22689573-2	2012	The Ub-interacting motif (UIM) domain of Rap80, which is a component of the BRCA1-A complex, interacts with Ub Lys-63 linkage conjugates and mediates the recruitment of BRCA1 to DSBs.	Lysine	111-114	ubiquitin interaction motif containing 1	Homo sapiens	41-46
32378528-3	2020	Histone H4 lysine 20 monomethylation (H4K20me1) is involved in DNA damage repair and regulation of gene expression.	Lysine	11-17	LOC102641229	Mus musculus	0-10
21309033-1	2011	The covalent attachment of lysine 63-linked polyubiquitin to the zinc-finger domain of IKBKG/NEMO (also known as IKKgamma) is necessary for full activation of NF-kappaB.	Lysine	27-33	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	87-92
33240782-4	2020	USP38 specifically removes the monoubiquitin on H2B at lysine 120, which functions as a prerequisite for the subsequent recruitment of demethylase KDM5B to the promoters of proinflammatory cytokines Il6 and Il23a during LPS stimulation.	Lysine	55-61	lysine (K)-specific demethylase 5B	Mus musculus	147-152
32889380-2	2020	In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC50 of 0.6 +- 0.0421 muM in biochemical level, and can bind KDM1A recombinant directly and reversibly.	Lysine	45-51	lysine demethylase 1A	Homo sapiens	77-82
32889380-2	2020	In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC50 of 0.6 +- 0.0421 muM in biochemical level, and can bind KDM1A recombinant directly and reversibly.	Lysine	45-51	lysine demethylase 1A	Homo sapiens	83-87
22812534-10	2012	Pharmacological inhibition of KDM1 in vitro increased inhibitory histone mark dimethylation of histone H3 at lysine 9 (H3K9me2) and decreased histone activation mark acetylation of H3K9 (H3K9Ac) on ER target gene promoters.	Lysine	109-115	lysine demethylase 1A	Homo sapiens	30-34
22593578-10	2012	Remarkably, we found that bLF pretreatment inhibited LPS-mediated Lys-63-linked polyubiquitination of TNF receptor-associated factor 6 (TRAF6).	Lysine	66-69	TNF receptor associated factor 6	Bos taurus	102-134
22593578-10	2012	Remarkably, we found that bLF pretreatment inhibited LPS-mediated Lys-63-linked polyubiquitination of TNF receptor-associated factor 6 (TRAF6).	Lysine	66-69	TNF receptor associated factor 6	Bos taurus	136-141
21309033-1	2011	The covalent attachment of lysine 63-linked polyubiquitin to the zinc-finger domain of IKBKG/NEMO (also known as IKKgamma) is necessary for full activation of NF-kappaB.	Lysine	27-33	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	93-97
21309033-1	2011	The covalent attachment of lysine 63-linked polyubiquitin to the zinc-finger domain of IKBKG/NEMO (also known as IKKgamma) is necessary for full activation of NF-kappaB.	Lysine	27-33	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	113-121
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Lysine	50-56	orthodenticle homeobox 2	Mus musculus	85-89
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Lysine	50-56	orthodenticle homeobox 2	Mus musculus	177-181
21144910-5	2011	Variants of the third domain (D3) of receptor-associated protein (RAP) were created carrying lysine to alanine or arginine replacements at the putative contact residues K253, K256 and K270.	Lysine	93-99	LDL receptor related protein associated protein 1	Homo sapiens	37-64
21144910-5	2011	Variants of the third domain (D3) of receptor-associated protein (RAP) were created carrying lysine to alanine or arginine replacements at the putative contact residues K253, K256 and K270.	Lysine	93-99	LDL receptor related protein associated protein 1	Homo sapiens	66-69
21317535-5	2011	Expression of CSN6 appeared to prevent MDM2 autoubiquitination at lysine 364, resulting in stabilization of MDM2 and degradation of p53.	Lysine	66-72	transformed mouse 3T3 cell double minute 2	Mus musculus	39-43
22425524-5	2012	In addition, mutation analysis of TPR peptide demonstrated that the highly conserved amino acids Lys and Arg were critical to the cytotoxic activity.	Lysine	97-100	translocated promoter region, nuclear basket protein	Homo sapiens	34-37
32801097-1	2020	Lysyl oxidase-like 2 (LOXL2) is a copper-dependent amine oxidase that catalyzes the oxidative deamination of the epsilon-amino group of lysines/hydroxylysines on substrate proteins (collagen and elastin) to form aldehyde groups.	Lysine	136-143	elastin	Homo sapiens	195-202
21273441-0	2011	Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.	Lysine	0-6	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	69-73
32960142-6	2020	In this study, the inhibition of the residual activity of TIP60 in breast cancer cell lines was investigated by using two chemical inhibitors, TH1834 and NU9056, first on the acetylation of the specific target, lysine 4 of histone 3 (H3K4) by immunoblotting, and second, by chromatin immunoprecipitation (ChIP)-qPCR (-quantitative Polymerase Chain Reaction.	Lysine	211-217	lysine acetyltransferase 5	Homo sapiens	58-63
22635276-5	2012	Mutation of the MDC1 Lys 1840 (K1840R) results in impaired CtIP, replication protein A, and Rad51 accumulation at sites of DNA damage and defective homologous recombination (HR).	Lysine	21-24	mediator of DNA damage checkpoint 1	Homo sapiens	16-20
22635276-5	2012	Mutation of the MDC1 Lys 1840 (K1840R) results in impaired CtIP, replication protein A, and Rad51 accumulation at sites of DNA damage and defective homologous recombination (HR).	Lysine	21-24	RAD51 recombinase	Homo sapiens	92-97
22698398-2	2012	demonstrated that SIRT7 maintains critical features that define cancer cells by removing the acetylation mark on lysine 18 of histone H3.	Lysine	113-119	sirtuin 7	Homo sapiens	18-23
32805486-6	2020	Mechanistically, linc00174 directly bound to enhancer of zeste homolog 2 (EZH2), thus stimulating the protein level of trimethylation at lysine 27 of histone H3 (H3K27me3).	Lysine	137-143	long intergenic non-protein coding RNA 174	Homo sapiens	17-26
21273441-2	2011	We report that the androgen receptor (AR) is methylated at lysine-630 by Set9, which was originally identified as a histone H3K4 monomethyltransferase.	Lysine	59-65	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	73-77
20972224-6	2011	UV radiation induces the acetylation of histone H3 lysine 9 (H3K9) and this requires both GCN5 and E2F1.	Lysine	51-57	E2F transcription factor 1	Homo sapiens	99-103
32888405-4	2020	Lysine 102 in Smad7 is crucial for binding to specific consensus sites in c-Jun and HDAC6, even when endogenous Smad2, 3, and 4 were silenced by siRNA.	Lysine	0-6	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
22549777-6	2012	In addition, mutation of these two lysines into arginine residues significantly increases GLI2 transcriptional activity in a cell-based reporter assay.	Lysine	35-42	GLI-Kruppel family member GLI2	Mus musculus	90-94
21131325-1	2011	Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the polyamine-modified lysine, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)lysine].	Lysine	118-124	eukaryotic translation initiation factor 5A	Homo sapiens	45-50
22722204-5	2012	Here we show that PGC7 protects 5mC from Tet3-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 lysine 9 (H3K9me2) in mice.	Lysine	142-148	developmental pluripotency-associated 3	Mus musculus	18-22
32437589-1	2020	CONTEXT: Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.	Lysine	35-41	thyroid stimulating hormone receptor	Homo sapiens	105-117
32437589-1	2020	CONTEXT: Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.	Lysine	35-41	thyroid stimulating hormone receptor	Homo sapiens	119-124
21321203-6	2011	Here we report that PC-specific deletion of the mouse males absent on the first (mMof) gene (Cre(-)), which encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac) and influences ATM function, is critical for PC longevity.	Lysine	169-175	K(lysine) acetyltransferase 8	Mus musculus	81-85
32687671-8	2020	In response to agrin stimulation, APC2 negatively regulates AChR clustering by promoting the ubiquitination of DOK7 at lysine 243 for its proteolytic degradation, which relies on MuSK kinase activity and the phosphorylation of tyrosine 106 in DOK7.	Lysine	119-125	agrin	Homo sapiens	15-20
22494625-3	2012	METHODS: Small hairpin RNA plasmid specific for rabbit SR-BI was complexed with galactosylated poly-l-lysine, allowing an organ-selective, receptor-mediated gene transfer.	Lysine	95-108	scavenger receptor class B member 1	Oryctolagus cuniculus	55-60
22205671-5	2012	This nonsynonymous SNP converted glutamine (Q) in the slow phenotype to lysine (K) in the fast phenotype at AA residue 21 of mature lysozyme (Q21K).	Lysine	72-78	lysozyme C	Coturnix japonica	132-140
22302399-8	2012	It was found that combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with the two possible genotypes of XPD-Asp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Lysine	159-162	X-ray repair cross complementing 1	Homo sapiens	69-74
21423663-7	2011	A basal level of JIL-1 binding can be defined that correlates best with the methylation of histone H3 at lysine 36, a mark that is placed co-transcriptionally.	Lysine	105-111	JIL-1 kinase	Drosophila melanogaster	17-22
21423663-10	2011	In vivo, phosphorylation of H3 at serine 10, together with acetylation at lysine 14, creates a composite histone mark that is enriched at JIL-1 binding regions.	Lysine	74-80	JIL-1 kinase	Drosophila melanogaster	138-143
23189823-3	2012	TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination.	Lysine	49-55	tripartite motif containing 56	Homo sapiens	0-6
32413437-8	2020	Treatment of BV2 cells with LPS significantly reduced acetylation of histone H3 at lysine 9 of the alpha7 nAChR promoter.	Lysine	83-89	H3 clustered histone 7	Mus musculus	69-79
21177250-7	2011	By an in vitro motility assay, we found that lysine acetylation increased the actin sliding velocity of alpha-myosin by 20% and beta-myosin by 36%, compared to their respective non-acetylated isoforms.	Lysine	45-51	myosin heavy chain 14	Homo sapiens	110-116
32544411-6	2020	It was determined that OXL-induced endoplasmic reticulum stress (ERS) decreased because LY administration reduced the expressions of activating transcription factor-6 (ATF6), glucose-regulated protein-78 (GRP78), pancreatic endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme-1 (IRE1).	Lysine	88-90	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	175-203
32544411-6	2020	It was determined that OXL-induced endoplasmic reticulum stress (ERS) decreased because LY administration reduced the expressions of activating transcription factor-6 (ATF6), glucose-regulated protein-78 (GRP78), pancreatic endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme-1 (IRE1).	Lysine	88-90	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	205-210
22542627-2	2012	Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9.	Lysine	111-117	lysine demethylase 1A	Homo sapiens	0-29
22542627-2	2012	Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9.	Lysine	111-117	lysine demethylase 1A	Homo sapiens	31-35
22542627-2	2012	Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9.	Lysine	124-130	lysine demethylase 1A	Homo sapiens	0-29
21177250-7	2011	By an in vitro motility assay, we found that lysine acetylation increased the actin sliding velocity of alpha-myosin by 20% and beta-myosin by 36%, compared to their respective non-acetylated isoforms.	Lysine	45-51	myosin heavy chain 14	Homo sapiens	133-139
22542627-2	2012	Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9.	Lysine	124-130	lysine demethylase 1A	Homo sapiens	31-35
32943826-0	2020	Marker aided introgression of opaque 2 (o2) allele improving lysine and tryptophan in maize (Zea mays L.).	Lysine	61-67	regulatory protein opaque-2	Zea mays	30-38
21177250-9	2011	During induction of hypertrophy, myosin isoform acetylation increased progressively with duration of stress stimuli, independent of isoform shift, suggesting that lysine acetylation of myosin could be an early response of myofilaments to increase contractile performance of the heart.	Lysine	163-169	myosin heavy chain 14	Homo sapiens	33-39
21177250-9	2011	During induction of hypertrophy, myosin isoform acetylation increased progressively with duration of stress stimuli, independent of isoform shift, suggesting that lysine acetylation of myosin could be an early response of myofilaments to increase contractile performance of the heart.	Lysine	163-169	myosin heavy chain 14	Homo sapiens	185-191
32929358-6	2020	Results: HRG directly interacted with TNFR1 and stabilized TNFR1 protein by decreasing the Lys(K)-48 ubiquitination mediated-degradation.	Lysine	91-94	histidine rich glycoprotein	Homo sapiens	9-12
32929358-7	2020	The formation of TNFR1-complex II was prompted by HRG overexpression via upregulating Lys(K)-63 ubiquitination of TNFR1.	Lysine	86-89	histidine rich glycoprotein	Homo sapiens	50-53
22541069-6	2012	DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.	Lysine	87-93	FSHMD1A	Homo sapiens	56-60
20823277-0	2011	Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.	Lysine	0-6	sirtuin 1	Mus musculus	63-68
22442143-9	2012	Consistent with the delayed flowering and FT suppression in the OE-AHL22 mutant, histone 3 (H3) acetylation was reduced and H3 lysine 9 dimethylation was elevated in the FT chromatin.	Lysine	127-133	AT-hook motif nuclear-localized protein 22	Arabidopsis thaliana	67-72
32709337-2	2020	Herein, a new strategy for precise separation of lysine-specific demethylase 1 (LSD1) inhibitors from the rhizome of Corydalis yanhusuo (RCY) using counter-current chromatography (CCC) guided by molecular docking and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analysis was established.	Lysine	49-55	lysine demethylase 1A	Homo sapiens	80-84
21280010-11	2011	Consistent with these observations, DEK underwent acetylation on an unprecedented number of lysine residues, as demonstrated by nano-LC-MS/MS.	Lysine	92-98	DEK proto-oncogene	Homo sapiens	36-39
32882514-0	2020	KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.	Lysine	23-29	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
22227561-9	2012	TGF-beta(2) down-regulated ADAM33 mRNA expression by causing chromatin condensation around the ADAM33 promoter with deacetylation of histone H3, demethylation of H3 on lysine-4, and hypermethylation of H3 on lysine-9.	Lysine	168-174	transforming growth factor beta 2	Homo sapiens	0-11
22227561-9	2012	TGF-beta(2) down-regulated ADAM33 mRNA expression by causing chromatin condensation around the ADAM33 promoter with deacetylation of histone H3, demethylation of H3 on lysine-4, and hypermethylation of H3 on lysine-9.	Lysine	168-174	ADAM metallopeptidase domain 33	Homo sapiens	27-33
22227561-9	2012	TGF-beta(2) down-regulated ADAM33 mRNA expression by causing chromatin condensation around the ADAM33 promoter with deacetylation of histone H3, demethylation of H3 on lysine-4, and hypermethylation of H3 on lysine-9.	Lysine	208-214	transforming growth factor beta 2	Homo sapiens	0-11
22227561-9	2012	TGF-beta(2) down-regulated ADAM33 mRNA expression by causing chromatin condensation around the ADAM33 promoter with deacetylation of histone H3, demethylation of H3 on lysine-4, and hypermethylation of H3 on lysine-9.	Lysine	208-214	ADAM metallopeptidase domain 33	Homo sapiens	27-33
22227561-9	2012	TGF-beta(2) down-regulated ADAM33 mRNA expression by causing chromatin condensation around the ADAM33 promoter with deacetylation of histone H3, demethylation of H3 on lysine-4, and hypermethylation of H3 on lysine-9.	Lysine	208-214	ADAM metallopeptidase domain 33	Homo sapiens	95-101
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Lysine	189-195	protein arginine methyltransferase 1	Homo sapiens	0-5
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Lysine	189-195	protein arginine methyltransferase 1	Homo sapiens	116-121
32781547-6	2020	In addition, maternal chewing attenuated the increase in expression of DNMT1 and DNMT3a and the decrease in expression of histone H3 methylation at lysine 4, 9, 27 and histone H3 acetylation at lysine 9 induced by prenatal stress in the offspring.	Lysine	148-154	H3 clustered histone 7	Mus musculus	122-132
20979431-6	2011	An individual with combined COMT 158 (Val/Met or Met/Met) and XPD 751 (Lys/Gln or Gln/Gln) genotype had an increased ESCC risk.	Lysine	71-74	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	62-65
22375025-5	2012	Human PMSC is illuminated with epigenetic modifications such as trimethylated lysine 9 of histone H3 and heterochromatin proteins CBX1 and CBX3, which implicate a conserved mechanism underlying the maintenance of sex chromosome inactivation in mammals.	Lysine	78-84	chromobox 1	Homo sapiens	130-134
22549957-6	2012	An RNA-mediated knockdown screen identified SUVR4 {SUPPRESSOR OF VARIEGATION 3-9 [SU(VAR)3-9]-RELATED 4} as a histone H3 Lys 9 (H3K9) methyltransferase required for nucleolar dominance in A. suecica.	Lysine	121-124	SET-domain containing protein lysine methyltransferase family protein	Arabidopsis thaliana	44-49
32781547-6	2020	In addition, maternal chewing attenuated the increase in expression of DNMT1 and DNMT3a and the decrease in expression of histone H3 methylation at lysine 4, 9, 27 and histone H3 acetylation at lysine 9 induced by prenatal stress in the offspring.	Lysine	194-200	H3 clustered histone 7	Mus musculus	168-178
20978007-6	2011	Sirt1 siRNA enhanced TF protein and mRNA expression, and this effect was reduced in NFkappaB/p65(-/-) mouse embryonic fibroblasts reconstituted with non-acetylatable Lys(310)-mutant NFkappaB/p65.	Lysine	166-169	sirtuin 1	Mus musculus	0-5
32562311-1	2020	Enhancer of zeste homolog 2 (EZH2), a well-known methyltransferase, mediates histone H3 lysine 27 trimethylation (H3K27me3) and plays a vital role in ophthalmological disease.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
22452853-0	2012	The CHD3 remodeler PICKLE associates with genes enriched for trimethylation of histone H3 lysine 27.	Lysine	90-96	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	4-8
21212807-3	2011	Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282 is triggered by the kinase activities of IkappaB kinase e (IKKe) and TBK1.	Lysine	100-103	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	149-165
22452853-0	2012	The CHD3 remodeler PICKLE associates with genes enriched for trimethylation of histone H3 lysine 27.	Lysine	90-96	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	19-25
22452853-2	2012	PKL promotes the epigenetic mark trimethylation of histone H3 lysine 27 (H3K27me3) that facilitates repression of tissue-specific genes in plants.	Lysine	62-68	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	0-3
22393046-4	2012	Here, we identified that RhoGDI SUMOylation specifically occurred at Lys-138, which was inhibited by XIAP domain.	Lysine	69-72	X-linked inhibitor of apoptosis	Homo sapiens	101-105
32562311-1	2020	Enhancer of zeste homolog 2 (EZH2), a well-known methyltransferase, mediates histone H3 lysine 27 trimethylation (H3K27me3) and plays a vital role in ophthalmological disease.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
32559753-6	2020	Enzymes are covalently tethered to the capsid protein of TMV by the N- and C-terminal addition of lysine-rich assembly domains which react with surface exposed glutamine residues on the capsid surfaces; the lysine/glutamine linkages are mediated by a microbial transglutaminase (mTG).	Lysine	98-104	protease, serine 3	Mus musculus	279-282
21212807-3	2011	Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282 is triggered by the kinase activities of IkappaB kinase e (IKKe) and TBK1.	Lysine	100-103	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	167-171
21212807-3	2011	Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282 is triggered by the kinase activities of IkappaB kinase e (IKKe) and TBK1.	Lysine	100-103	TANK binding kinase 1	Homo sapiens	177-181
22496563-7	2012	The major sites of AChRalpha ubiquitination reside within the large intracellular loop and mutations of critical lysine residues in this loop to arginine increased AChRalpha stability in the absence of alphakap.	Lysine	113-119	cholinergic receptor nicotinic alpha 1 subunit	Homo sapiens	164-173
32850370-3	2020	LSD1, a histone lysine-specific demethylase, is known to promote cancer cell proliferation, metastasis, and chemoresistance.	Lysine	16-22	lysine demethylase 1A	Homo sapiens	0-4
21094170-0	2011	A lysine-free mutant of epidermal growth factor as targeting moiety of a targeted toxin.	Lysine	2-8	epidermal growth factor	Homo sapiens	24-47
32544088-3	2020	Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal (BET) family of proteins that function as epigenetic "readers" of acetylated lysine groups on histones.	Lysine	166-172	delta/notch-like EGF repeat containing	Mus musculus	90-93
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	55-58	damage specific DNA binding protein 1	Homo sapiens	146-150
22334663-6	2012	We demonstrate functionally that ubiquitination of H2A Lys-119/Lys-120 is necessary for destabilization of nucleosomes and concomitant release of DDB1-CUL4B(DDB2) from photolesion-containing DNA.	Lysine	63-66	damage specific DNA binding protein 1	Homo sapiens	146-150
32690000-1	2020	BACKGROUND: The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.	Lysine	143-149	E1A binding protein p300	Mus musculus	74-78
21094170-4	2011	MAIN METHODS: We designed an EGF variant (EGF(RR)) in which the two lysines were substituted with arginine (K28R and K48R).	Lysine	68-75	epidermal growth factor	Homo sapiens	29-32
22354964-7	2012	Hypoxic stress-induced de-SUMOylation of human CTCF was associated with lysine 74 and 689 residues, but not to the phosphorylation of CTCF.	Lysine	72-78	CCCTC-binding factor	Homo sapiens	47-51
32567837-0	2020	Nucleosome binding by the lysine specific demethylase 1 (LSD1) enzyme enables histone H3 demethylation.	Lysine	26-32	lysine demethylase 1A	Homo sapiens	57-61
21094170-4	2011	MAIN METHODS: We designed an EGF variant (EGF(RR)) in which the two lysines were substituted with arginine (K28R and K48R).	Lysine	68-75	epidermal growth factor	Homo sapiens	42-45
32567837-1	2020	The essential human enzyme lysine specific deme-thylase 1 (LSD1) silences genes by demethylating mono- and dimethylated lysine 4 in histone H3 (H3K4me1/2).	Lysine	27-33	lysine demethylase 1A	Homo sapiens	59-63
22431625-4	2012	H3.1 was enriched in silent areas of the genome, including regions containing the repressive chromatin modifications H3 lysine 27 methylation, H3 lysine 9 methylation, and DNA methylation.	Lysine	120-126	Histone superfamily protein	Arabidopsis thaliana	0-4
22431625-4	2012	H3.1 was enriched in silent areas of the genome, including regions containing the repressive chromatin modifications H3 lysine 27 methylation, H3 lysine 9 methylation, and DNA methylation.	Lysine	146-152	Histone superfamily protein	Arabidopsis thaliana	0-4
21276944-5	2011	One lysine in the MINT protein is dimethylated in vitro and in vivo demonstrating that the product pattern created by SET7/9 depends on the amino acid sequence context of the target site.	Lysine	4-10	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	118-124
21287358-0	2012	The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs.	Lysine	41-47	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	18-21
21304913-1	2011	Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18.	Lysine	65-71	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	187-191
32510829-2	2020	A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues.	Lysine	133-139	FA complementation group D2	Homo sapiens	94-100
32510829-2	2020	A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues.	Lysine	133-139	inhibitor of DNA binding 2	Homo sapiens	109-112
22345352-3	2012	This structure is established by the action of silent information regulator proteins (Sir2, Sir3, and Sir4) that bind to nucleosomes and initiate the deacetylation of multiple lysine residues in histones H3 and H4.	Lysine	176-182	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	92-96
21304947-2	2011	The chromo domain protein like heterochromatin protein1 (LHP1) is a subunit of a plant PRC1-like complex in Arabidopsis thaliana and recognizes histone H3 lysine 27 trimethylation, a silencing epigenetic mark deposited by the PRC2 complex.	Lysine	155-161	like heterochromatin protein (LHP1)	Arabidopsis thaliana	26-55
22345352-3	2012	This structure is established by the action of silent information regulator proteins (Sir2, Sir3, and Sir4) that bind to nucleosomes and initiate the deacetylation of multiple lysine residues in histones H3 and H4.	Lysine	176-182	chromatin-silencing protein SIR4	Saccharomyces cerevisiae S288C	102-106
21304947-2	2011	The chromo domain protein like heterochromatin protein1 (LHP1) is a subunit of a plant PRC1-like complex in Arabidopsis thaliana and recognizes histone H3 lysine 27 trimethylation, a silencing epigenetic mark deposited by the PRC2 complex.	Lysine	155-161	like heterochromatin protein (LHP1)	Arabidopsis thaliana	57-61
32416562-5	2020	NF-kB translocation may occur due to acetylation and phosphorylation LYS 310 and SER311 amino acids in chain A of the p65 subunit in response to IKK-alpha/beta activity.	Lysine	69-72	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	145-154
21969221-2	2011	Myc binding to its targets depends on the presence of the E-box binding sequence and by a chromatin context in which histone H3K4me3 lysine methylation favors Myc binding.	Lysine	133-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
32553389-3	2020	Enhancer of zeste homolog 2 (EZH2), a methyltransferase of histone H3 lysine 27 which regulates microglial activation, plays a crucial role in proinflammatory cytokines expression.	Lysine	70-76	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
32553389-3	2020	Enhancer of zeste homolog 2 (EZH2), a methyltransferase of histone H3 lysine 27 which regulates microglial activation, plays a crucial role in proinflammatory cytokines expression.	Lysine	70-76	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
22134899-1	2012	JMJD2A is a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysines 9 and 36 and is overexpressed in human tumors, but its role in oncogenesis remains unclear.	Lysine	91-98	lysine demethylase 4A	Homo sapiens	0-6
21969221-2	2011	Myc binding to its targets depends on the presence of the E-box binding sequence and by a chromatin context in which histone H3K4me3 lysine methylation favors Myc binding.	Lysine	133-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-162
21985917-11	2012	Although the lysine encoded by AAG was identical to the lysine encoded by AAA, it is not clear if they have functional differences due to the changing environmental conditions.	Lysine	13-19	N-methylpurine DNA glycosylase	Homo sapiens	31-34
20615470-3	2011	Lysine 51 is a highly conserved residue located in the RNA-binding region of Tat and the target of lysine methyltransferases KMT1E (SETDB1) and KMT7 (Set7/9).	Lysine	0-6	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	144-148
21985917-11	2012	Although the lysine encoded by AAG was identical to the lysine encoded by AAA, it is not clear if they have functional differences due to the changing environmental conditions.	Lysine	56-62	N-methylpurine DNA glycosylase	Homo sapiens	31-34
21985917-11	2012	Although the lysine encoded by AAG was identical to the lysine encoded by AAA, it is not clear if they have functional differences due to the changing environmental conditions.	Lysine	56-62	AAA1	Homo sapiens	74-77
32606301-2	2020	The current study investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metabolic proteins in response to a high fat diet (HFD).	Lysine	55-61	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	39-45
32606301-9	2020	We conclude that increased GCN5L1 expression in response to a HFD promotes increased lysine acetylation, and that this may play a role in the development of reactive oxygen species (ROS) damage caused by nutrient excess.	Lysine	85-91	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	27-33
21913221-8	2012	In the current study, we identify Lysine 392 residue in NEMO as crucial mediator of PMMA particle-induced inflammatory osteoclastogenesis and osteolysis.	Lysine	34-40	inhibitor of kappaB kinase gamma	Mus musculus	56-60
20615470-3	2011	Lysine 51 is a highly conserved residue located in the RNA-binding region of Tat and the target of lysine methyltransferases KMT1E (SETDB1) and KMT7 (Set7/9).	Lysine	0-6	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	150-156
20615470-4	2011	Using affinity-purified methyl-specific antibodies of Tat, we find that cellular Tat is predominantly monomethylated at lysine 51, a modification enhanced by coexpression of KMT7.	Lysine	120-126	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	174-178
21318875-2	2011	A portion of spermidine is covalently added to one specific lysine residue of one eukaryotic protein, eIF5A (eukaryotic initiation factor 5A) to form a deoxyhypusine residue.	Lysine	60-66	eukaryotic translation initiation factor 5A	Homo sapiens	102-107
22337870-2	2012	The interaction of Rtt106 with H3-H4 is modulated by acetylation of H3 lysine 56 catalyzed by the lysine acetyltransferase Rtt109.	Lysine	71-77	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	123-129
22402282-2	2012	JMJD5 (jumonji C domain-containing 5) is a histone demethylase that specifically removes methyl moieties from dimethylated lysine 36 on histone H3 and exerts a pro-proliferative effect on breast cancer cells.	Lysine	123-129	lysine (K)-specific demethylase 8	Mus musculus	0-5
22402282-2	2012	JMJD5 (jumonji C domain-containing 5) is a histone demethylase that specifically removes methyl moieties from dimethylated lysine 36 on histone H3 and exerts a pro-proliferative effect on breast cancer cells.	Lysine	123-129	lysine (K)-specific demethylase 8	Mus musculus	7-36
32334834-5	2020	More intriguingly, replacement of Lysine 164 residue of ING3 with alanine (K164A) resulted in retention of ING3 in the cytoplasm.	Lysine	34-40	inhibitor of growth family member 3	Homo sapiens	56-60
32334834-5	2020	More intriguingly, replacement of Lysine 164 residue of ING3 with alanine (K164A) resulted in retention of ING3 in the cytoplasm.	Lysine	34-40	inhibitor of growth family member 3	Homo sapiens	107-111
21318875-2	2011	A portion of spermidine is covalently added to one specific lysine residue of one eukaryotic protein, eIF5A (eukaryotic initiation factor 5A) to form a deoxyhypusine residue.	Lysine	60-66	eukaryotic translation initiation factor 5A	Homo sapiens	109-140
22046413-5	2011	Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells.	Lysine	99-105	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	32-37
32584788-4	2020	Specifically, SIRT6 mono-ADP ribosylates the lysine demethylase JHDM1A/KDM2A leading to rapid displacement of KDM2A from chromatin, resulting in increased H3K36me2 levels.	Lysine	45-51	lysine demethylase 2A	Homo sapiens	64-70
32584788-4	2020	Specifically, SIRT6 mono-ADP ribosylates the lysine demethylase JHDM1A/KDM2A leading to rapid displacement of KDM2A from chromatin, resulting in increased H3K36me2 levels.	Lysine	45-51	lysine demethylase 2A	Homo sapiens	71-76
32584788-4	2020	Specifically, SIRT6 mono-ADP ribosylates the lysine demethylase JHDM1A/KDM2A leading to rapid displacement of KDM2A from chromatin, resulting in increased H3K36me2 levels.	Lysine	45-51	lysine demethylase 2A	Homo sapiens	110-115
22449979-0	2012	Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes.	Lysine	0-6	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	73-76
22440088-4	2012	DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a pathway that controls methylation of the histone H3 globular domain at lysine 79 (H3K79), thereby modulating expression of the ENaCalpha subunit.	Lysine	119-125	sirtuin 1	Homo sapiens	14-19
22440088-4	2012	DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a pathway that controls methylation of the histone H3 globular domain at lysine 79 (H3K79), thereby modulating expression of the ENaCalpha subunit.	Lysine	119-125	serum/glucocorticoid regulated kinase 1	Homo sapiens	25-29
22046413-5	2011	Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells.	Lysine	99-105	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	38-41
32395997-10	2020	Finally, negatively charged residues at position +2 and +4 are involved in electrostatic interactions with two lysines (Lys89 and Lys91) specific of the SHP2 N-SH2 domain.	Lysine	111-118	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	153-157
21935442-7	2011	An in vitro proteome-derived peptide library Nt-acetylation assay indicated that recombinant hNaa40p acetylates N-termini starting with the consensus sequence Ser-Gly-Gly-Gly-Lys-, strongly resembling the N-termini of the human histones H2A and H4.	Lysine	175-178	N-alpha-acetyltransferase 40, NatD catalytic subunit	Homo sapiens	93-100
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	C-C motif chemokine ligand 5	Rattus norvegicus	59-65
32760202-5	2020	Meanwhile, KAT7 also bound to the same region of MCP-1 and RANTES promoter in a KLF6-dependent manner, and KLF6 was acetylated by KAT7 at lysine residue 100, which finally promoted MCP-1 and RANTES expression.	Lysine	138-144	C-C motif chemokine ligand 5	Rattus norvegicus	191-197
22132744-3	2012	LSD1 (lysine-specific demethylase 1) was the first enzyme identified to specifically demethylate H3K4 (Lys(4) of histone H3).	Lysine	103-106	lysine demethylase 1A	Homo sapiens	0-4
22132744-3	2012	LSD1 (lysine-specific demethylase 1) was the first enzyme identified to specifically demethylate H3K4 (Lys(4) of histone H3).	Lysine	103-106	lysine demethylase 1A	Homo sapiens	6-35
22194422-9	2012	In OP rats, the increase of p16(INK4a) was associated with the higher acetylation levels of histone H4 at the p16(INK4a) promoter and coding region and lower methylation level of histone H3 lysine-27 in the p16(INK4a) coding region.	Lysine	190-196	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	28-31
21935442-9	2011	In contrast, a synthetically Nt-acetylated H4 N-terminal peptide with all lysines being non-acetylated, was not significantly acetylated by hNaa40p, indicating that hNaa40p catalyzed H4 N(alpha)-acetylation and not H4 lysine N(epsilon)-acetylation.	Lysine	74-81	N-alpha-acetyltransferase 40, NatD catalytic subunit	Homo sapiens	165-172
22194422-9	2012	In OP rats, the increase of p16(INK4a) was associated with the higher acetylation levels of histone H4 at the p16(INK4a) promoter and coding region and lower methylation level of histone H3 lysine-27 in the p16(INK4a) coding region.	Lysine	190-196	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	32-37
22194422-10	2012	The increase of p21(Cip1) was associated with increased acetylation of both histone H3 and H4 and decreased trimethylation of histone H3 lysine-27 at the p21(Cip1) promoter.	Lysine	137-143	KRAS proto-oncogene, GTPase	Rattus norvegicus	16-19
21857907-8	2011	In addition, acetylation of p53 (Lys 379) and p53-DNA binding activity were increased and cell death unchanged after miR-34a overexpression, thus reinforcing the role of p53 during neural differentiation.	Lysine	33-36	transformation related protein 53, pseudogene	Mus musculus	28-31
22194422-10	2012	The increase of p21(Cip1) was associated with increased acetylation of both histone H3 and H4 and decreased trimethylation of histone H3 lysine-27 at the p21(Cip1) promoter.	Lysine	137-143	KRAS proto-oncogene, GTPase	Rattus norvegicus	154-157
22194422-11	2012	In the p21(Cip1) coding region, dimethylation of histone H3 lysine-4 was significantly higher (P &lt;0.05) in livers of OP rats compared with OR rats.	Lysine	60-66	KRAS proto-oncogene, GTPase	Rattus norvegicus	7-10
32439758-3	2020	Lack of Cdk8 impaired Ezh2 recruitment and the establishment of histone H3 lysine 27 tri-methylation but not PRC1 recruitment by Xist Transgenic expression of wild-type but not catalytically inactive Cdk8 restored efficient gene repression and PRC2 recruitment.	Lysine	75-81	cyclin-dependent kinase 8	Mus musculus	8-12
33367258-3	2020	Here, we show that SEU is a substrate of SUMO1, and that substitution of four conserved lysine residues disrupts the SUMOylation of SEU, impairs its function in photo- and thermomorphogenesis, and enhances its interaction with PHYTOCHROME-INTERACTING FACTOR 4 transcription factors.	Lysine	88-94	small ubiquitin-like modifier 1	Arabidopsis thaliana	41-46
21901142-6	2011	We found that alanine 52 in extracellular loop 2, glycine 254 in transmembrane (TM) region 2 and intracellular lysine 385 determine the positive modulation of alpha(1) GlyRs by NA-Gly.	Lysine	111-117	glycine receptor alpha 1	Homo sapiens	159-173
32404984-4	2020	Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.	Lysine	41-47	sirtuin 7	Mus musculus	14-19
32451438-3	2020	Human embryonic stem cells (hESCs) have a unique chromatin architecture characterized by low levels of trimethylated histone H3 at lysine 9 (H3K9me3), a heterochromatin-associated modification.	Lysine	131-137	Histone H3	Caenorhabditis elegans	117-127
21749932-0	2012	Lysine residues of ABCA1 are required for the interaction with apoA-I.	Lysine	0-6	ATP binding cassette subfamily A member 1	Homo sapiens	19-24
21749932-5	2012	The apoA-I binding to ABCA1 and the cross-linking between them were inhibited by the highly charged molecules heparin and poly-L-lysine.	Lysine	122-135	ATP binding cassette subfamily A member 1	Homo sapiens	22-27
21749932-8	2012	These results suggest that lysine residues in the extracellular domains of ABCA1 contribute to the interaction with apoA-I.	Lysine	27-33	ATP binding cassette subfamily A member 1	Homo sapiens	75-80
22792718-4	2012	We identified of acetetylated lysines K-17 and K-57 in alpha subunit of human hemoglobin after incubation whole blood with 0.1 mg/mL acetylsalicylic acid during 3 h.	Lysine	30-37	keratin 17	Homo sapiens	38-42
21901142-8	2011	Conversely, mutation of the conserved lysine within the intracellular loop between TM3 and TM4 attenuated NA-Gly-mediated potentiation of alpha(1) GlyRs, without affecting inhibition of alpha(2) and alpha(3).	Lysine	38-44	glycine receptor alpha 1	Homo sapiens	138-152
22227369-4	2012	Mutagenesis experiments revealed that the two SUMO-binding lysine residues of Zac1, K237 and K424, repress the transactivation activity of Zac1.	Lysine	59-65	PLAG1 like zinc finger 1	Homo sapiens	78-82
22227369-4	2012	Mutagenesis experiments revealed that the two SUMO-binding lysine residues of Zac1, K237 and K424, repress the transactivation activity of Zac1.	Lysine	59-65	PLAG1 like zinc finger 1	Homo sapiens	139-143
21151599-14	2010	FDP-lysine accumulation was associated with the induction of HO-1, no change in GFAP, a decrease in protein levels of the potassium channel subunit Kir4.1, and upregulation of transcripts for VEGF, IL-6, and TNF-alpha.	Lysine	4-10	heme oxygenase 1	Homo sapiens	61-65
22279139-7	2012	Subsequent chromatin immunoprecipitation analysis further demonstrated that the binding of p300/CBP-associated factor, a coactivator of SREBP-1c, and histone H3 lysine 14 acetylation at the FAS, SCD1, and ACC1 promoters were significantly reduced in the livers of APOE2 mice and HepG2 cells treated with MOEO compared with their controls.	Lysine	161-167	stearoyl-Coenzyme A desaturase 1	Mus musculus	195-199
21109198-6	2010	SIRT3 deacetylates two critical lysine residues on SOD2 and promotes its antioxidative activity.	Lysine	32-38	sirtuin 3	Mus musculus	0-5
26889411-4	2012	DNA sequence analysis of the PROS1 gene identified a novel heterozygous nonsense mutation in exon 10 by transition of AAG (lysine) to TAG (stop codon) at codon 473 (c.1417A&gt;T, p.K473X).	Lysine	123-129	N-methylpurine DNA glycosylase	Homo sapiens	118-121
22585859-6	2012	In the death-inducing signaling complex, the C-terminal zinc finger (Znf) domain of the A20 ubiquitin ligase mediates receptor-interacting protein 1 polyubiquitination through lysine-63-linked polyubiquitin chains, which bind to the caspase-8 protease domain and inhibit caspase-8 dimerization, cleavage, and the initiation of TRAIL-induced apoptosis in glioblastoma-derived cell lines and tumor-initiating cells.	Lysine	176-182	immunoglobulin kappa variable 1-27	Homo sapiens	88-91
32550227-7	2020	These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.	Lysine	66-72	AKT serine/threonine kinase 3	Homo sapiens	242-246
32249212-0	2020	SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation.	Lysine	49-52	SUMO1 activating enzyme subunit 1	Homo sapiens	67-71
32334587-4	2020	RESULTS: In this study, several engineering approaches formerly used for the low-affinity glucose transporters in Saccharomyces cerevisiae, were successfully applied for earlier identified transporter Hxt1 in Ogataea polymorpha to improve xylose consumption (engineering involved asparagine substitution to alanine at position 358 and replacement of N-terminal lysine residues predicted to be the target of ubiquitination for arginine residues).	Lysine	361-367	hexose transporter HXT1	Saccharomyces cerevisiae S288C	201-205
20693536-7	2010	Along the H19/Igf2 imprinted domain, allele-specific acetylation at each lysine residue depended on functional CTCF binding sites in the imprinting control region.	Lysine	73-79	insulin-like growth factor 2	Mus musculus	14-18
22241836-10	2012	Chromatin immunoprecipitation analysis showed that increased di-methylated lysine 36 of histone H3 (H3K36me2) and reduced recruitment of endogenous Jmjd5 were detected in the transcribed regions of Cdkn1a in Jmjd5(neo/neo) MEFs.	Lysine	75-81	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	198-204
20870717-7	2010	The down-regulation by K5 is dependent on both its RING domain and a membrane-proximal lysine in the cytoplasmic domain of BMPR-II.	Lysine	87-93	bone morphogenetic protein receptor type 2	Homo sapiens	123-130
21953514-8	2012	Chromatin immunoprecipitation assays further revealed that ethanol exposure significantly increased the association of acetylated histone H3 at lysine 9 with the SRE-containing region in the promoter of the lipin-1 gene.	Lysine	144-150	lipin 1	Mus musculus	207-214
32332759-4	2020	Upon DSB induction, SIRT1 translocates to the nucleus and deacetylates FOXL2 at lysine 124, leading to liberation of XRCC5 and XRCC6 from FOXL2 and formation of the Ku complex.	Lysine	80-86	sirtuin 1	Homo sapiens	20-25
32332759-4	2020	Upon DSB induction, SIRT1 translocates to the nucleus and deacetylates FOXL2 at lysine 124, leading to liberation of XRCC5 and XRCC6 from FOXL2 and formation of the Ku complex.	Lysine	80-86	forkhead box L2	Homo sapiens	71-76
32332759-4	2020	Upon DSB induction, SIRT1 translocates to the nucleus and deacetylates FOXL2 at lysine 124, leading to liberation of XRCC5 and XRCC6 from FOXL2 and formation of the Ku complex.	Lysine	80-86	X-ray repair cross complementing 6	Homo sapiens	127-132
20870719-3	2010	Here we demonstrate that RB can be methylated by SMYD2 at lysine 860, a highly conserved and novel site of modification.	Lysine	58-64	SET and MYND domain containing 2	Homo sapiens	49-54
32238799-6	2020	Further, we found that ubiquitin ligase HUWE1 induced the K27-/K29-linked noncanonical ubiquitination of JMJD1A at lysine-918.	Lysine	115-121	lysine demethylase 3A	Homo sapiens	105-111
21059912-5	2010	ETO2 commonly repressed GATA-1 function via suppressing histone H3 acetylation, although it also regulated methylation of histone H3 at lysine 27 at select loci.	Lysine	136-142	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	0-4
31482666-1	2020	A reengineered human cellular retinol binding protein II (hCRBPII), a 15-kDa protein belonging to the intracellular lipid binding protein (iLBP) family, generates a highly fluorescent red pigment through the covalent linkage of a merocyanine aldehyde to an active site lysine residue.	Lysine	269-275	fatty acid binding protein 6	Homo sapiens	102-137
31482666-1	2020	A reengineered human cellular retinol binding protein II (hCRBPII), a 15-kDa protein belonging to the intracellular lipid binding protein (iLBP) family, generates a highly fluorescent red pigment through the covalent linkage of a merocyanine aldehyde to an active site lysine residue.	Lysine	269-275	fatty acid binding protein 6	Homo sapiens	139-143
22379573-11	2012	GOX-induced apoptosis was inhibited by midazolam and the finding was diminished by LY-294002.	Lysine	83-85	hydroxyacid oxidase 1	Homo sapiens	0-3
22190494-12	2012	Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.	Lysine	54-60	sirtuin 1	Homo sapiens	24-29
22190494-12	2012	Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.	Lysine	162-168	sirtuin 1	Homo sapiens	24-29
22036579-1	2012	Here we demonstrate that a dramatic actin polymerizing activity caused by ectopic expression of the synaptic vesicle protein synaptotagmin 1 that results in extensive filopodia formation is due to the presence of a lysine rich sequence motif immediately at the cytoplasmic side of the transmembrane domain of the protein.	Lysine	215-221	synaptotagmin I	Mus musculus	125-140
21097931-2	2010	Brownian dynamics simulations show that Mb in which three surface acid residues are mutated to lysine binds b(5) in an ensemble of configurations distributed around a reactive most-probable structure.	Lysine	95-101	myoglobin	Homo sapiens	40-42
22339659-2	2012	LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process.	Lysine	77-83	lysine demethylase 1A	Homo sapiens	0-4
32185393-6	2020	CYLD encodes a lysine 63 deubiquitinase and CYLD cutaneous syndrome, a skin tumour disorder, is caused by mutations that lead to reduced deubiquitinase activity.	Lysine	15-21	CYLD lysine 63 deubiquitinase	Homo sapiens	0-4
21073748-5	2010	The region encompassed residues 545 to 585 of the full-length human SRP72 and contained a lysine-rich cluster (KKKKKKKKGK) at postions 552 to 561 as well as a conserved Pfam motif with the sequence PDPXRWLPXXER at positions 572 to 583.	Lysine	90-96	signal recognition particle 72	Homo sapiens	68-73
32114388-11	2020	Mechanically, ZHX2 suppressed liver CSCs via inhibiting KDM2A-mediated demethylation of histone H3 lysine 36 (H3K36) at the promoter regions of stemness-associated transcription factors, such as NANOG, SOX4 and OCT4.	Lysine	99-105	lysine demethylase 2A	Homo sapiens	56-61
22856664-2	2012	Mutation of Bax at lysine 128 (BaxK128E) abrogates its inhibitory effects on mtKv1.3 and prevents apoptosis.	Lysine	19-25	BCL2-associated X protein	Mus musculus	12-15
20805223-7	2010	Modest overexpression of OGT alters mitotic histone post-translational modifications at Lys-9, Ser-10, Arg-17, and Lys-27 of histone H3.	Lysine	88-91	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	25-28
22157242-2	2012	A recent study showed that Cdkal1 was a mammalian methythiotransferase, which specifically synthesizes 2-methylthio-N (6)-threonylcarbamoyladenosine (ms (2)t (6)A) at position 37 of tRNA(lys)(UUU).	Lysine	187-190	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	27-33
32114388-11	2020	Mechanically, ZHX2 suppressed liver CSCs via inhibiting KDM2A-mediated demethylation of histone H3 lysine 36 (H3K36) at the promoter regions of stemness-associated transcription factors, such as NANOG, SOX4 and OCT4.	Lysine	99-105	Nanog homeobox	Homo sapiens	195-200
31990587-2	2020	As ATB0,+ is highly expressed in pancreatic cancer, we also examined the therapeutic utility of ATB0,+-targeted liposomal drug delivery to treat this cancer.Results: The uptake of lysine-conjugated liposomes (LYS-LPs) was greater in ATB0,+-positive MCF7 cells.	Lysine	180-186	solute carrier family 1 member 5	Homo sapiens	3-7
31990587-2	2020	As ATB0,+ is highly expressed in pancreatic cancer, we also examined the therapeutic utility of ATB0,+-targeted liposomal drug delivery to treat this cancer.Results: The uptake of lysine-conjugated liposomes (LYS-LPs) was greater in ATB0,+-positive MCF7 cells.	Lysine	180-186	solute carrier family 1 member 5	Homo sapiens	96-100
22570767-5	2012	NFs are phosphorylated on highly conserved lysine-serine-proline (KSP) repeats located along the C-termini of both NF-M and NF-H within myelinated axonal regions.	Lysine	43-49	neurofilament medium chain	Homo sapiens	115-119
31990587-2	2020	As ATB0,+ is highly expressed in pancreatic cancer, we also examined the therapeutic utility of ATB0,+-targeted liposomal drug delivery to treat this cancer.Results: The uptake of lysine-conjugated liposomes (LYS-LPs) was greater in ATB0,+-positive MCF7 cells.	Lysine	180-186	solute carrier family 1 member 5	Homo sapiens	96-100
20805223-7	2010	Modest overexpression of OGT alters mitotic histone post-translational modifications at Lys-9, Ser-10, Arg-17, and Lys-27 of histone H3.	Lysine	115-118	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	25-28
31990587-7	2020	Moreover, LYS-LPs also enhanced the uptake and cytotoxicity of gemcitabine in these cells in an ATB0,+-dependent manner.Conclusions: We conclude that ATB0,+ could be exploited for targeted drug delivery in the form of lysine-conjugated liposomes and that the approach represents a novel strategy for enhanced pancreatic cancer therapy.	Lysine	218-224	solute carrier family 1 member 5	Homo sapiens	150-154
21940714-5	2012	Herein, the authors describe the development and optimization of homogeneous LANCE Ultra and AlphaLISA antibody-based assays for measuring the catalytic activity of two epigenetic enzymes acting on lysine 4 of histone H3: SET7/9 methyltransferase and LSD1 demethylase.	Lysine	198-204	lysine demethylase 1A	Homo sapiens	251-255
20512599-4	2010	Here, we identify a novel metabolite, Nepsilon-Hcy-Lys, in human and mouse plasma, and show that this metabolite is elevated in genetic (cystathionine beta-synthase deficiency in humans and mice, methylenetetrahydrofolate reductase deficiency in mice) or dietary (high Met diet in mice) deficiencies in Hcy metabolism.	Lysine	51-54	cystathionine beta-synthase	Mus musculus	137-164
21922516-3	2012	Here we show that beta amyloid increases somatostatin and cortistatin gene expression mainly through an increase in histone 3 lysine 4 methylation (H3K4me3), a modification associated with transcriptional activation.	Lysine	126-132	somatostatin	Homo sapiens	41-53
21994266-6	2012	The glial ACD-1, together with the neuronal DEG/ENaC DEG-1, is necessary for acid avoidance and attraction to lysine.	Lysine	110-116	Uncharacterized protein	Caenorhabditis elegans	10-15
31873223-6	2020	Consequently, a basic triad unique to UBE2T engages a structured acidic patch near the target lysine on FANCD2.	Lysine	94-100	FA complementation group D2	Homo sapiens	104-110
32115028-13	2020	At low lysine concentrations, adiponectin was not expressed in both pancreas and intestines.	Lysine	7-13	adiponectin, C1Q and collagen domain containing	Gallus gallus	30-41
32115028-14	2020	High lysine concentration exhibited increased growth, upregulation of ghrelin in the liver, and downregulation of ghrelin in the intestines, and both adiponectin and leptin in the liver.	Lysine	5-11	ghrelin/obestatin prepropeptide	Gallus gallus	70-77
32115028-14	2020	High lysine concentration exhibited increased growth, upregulation of ghrelin in the liver, and downregulation of ghrelin in the intestines, and both adiponectin and leptin in the liver.	Lysine	5-11	ghrelin/obestatin prepropeptide	Gallus gallus	114-121
21115940-5	2010	One SCC had a missense mutation at codon 285 (GAG&gt;AAG, Glu&gt;Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT&gt;CAT, Arg&gt;His).	Lysine	65-68	serpin family B member 3	Homo sapiens	4-7
32115028-14	2020	High lysine concentration exhibited increased growth, upregulation of ghrelin in the liver, and downregulation of ghrelin in the intestines, and both adiponectin and leptin in the liver.	Lysine	5-11	adiponectin, C1Q and collagen domain containing	Gallus gallus	150-161
32115028-16	2020	Expression of leptin was positively correlated with adiponectin in the hypothalamus and liver (P < 0.05), exhibiting satiety effects when the concentrations of lysine were low.	Lysine	160-166	adiponectin, C1Q and collagen domain containing	Gallus gallus	52-63
22072751-2	2012	In this study, we demonstrate that Sendai virus (SeV) infection results in the IKKepsilon- or TBK1-mediated phosphorylation of XIAP in vivo at Ser430, resulting in Lys(48)-linked autoubiquitination at Lys322/328 residues, followed by the subsequent proteasomal degradation of XIAP.	Lysine	164-167	X-linked inhibitor of apoptosis	Homo sapiens	127-131
21933813-3	2012	Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail.	Lysine	156-162	Cbl proto-oncogene like 2	Homo sapiens	71-90
22829782-8	2012	Finally, we report that Ubp10 counteracts Rad18 E3-ubiquitin ligase activity on PCNA at lysine 164 in such a manner that deregulation of Ubp10 expression causes tolerance impairment and MMS hypersensitivity.	Lysine	88-94	ubiquitin-specific protease UBP10	Saccharomyces cerevisiae S288C	24-29
20813976-6	2010	Histone H4 lysine acetylation and histone H3 acetylation and phosphorylation in the heat shock element (HSE) of the promoters of heat shock protein-70 (hsp70) and -90 (hsp90) genes were examined.	Lysine	11-17	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	129-150
23251702-10	2012	Interestingly, inhibition of E2F1 demethylation using an irreversible inhibitor of lysine-specific demethylase 1 reduced both TMCG/DIPY-mediated RASSF1A expression and apoptosis in MDA-MB-231 cells, suggesting that DNA and protein demethylation may act together to control these molecular and cellular processes.	Lysine	83-89	Ras association domain family member 1	Homo sapiens	145-152
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	nuclear receptor coactivator 3	Mus musculus	27-32
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	hepatocyte growth factor	Mus musculus	172-175
23251711-5	2012	The aim of this study was to evaluate the role of p63 during mouse neural stem cell (NSC) differentiation and test whether the histone H3 lysine 27-specific demethylase JMJD3 interacts with p63 to redirect NSCs to neurogenesis.	Lysine	138-144	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	169-174
20837706-1	2010	MOF (MYST1) is the major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution.	Lysine	70-76	K(lysine) acetyltransferase 8	Mus musculus	0-3
23029429-5	2012	After having identified the acetyltransferase p300 among several acetyltransferases to be associated with Rb2/p130 during S-phase in NIH3T3 cells in vivo, we used this enzyme and the CDK4 protein kinase for in vitro modification of a variety of full length Rb2/p130 and truncated versions with mutations in the acetylatable lysine residues 1079, 128 and 130.	Lysine	324-330	E1A binding protein p300	Mus musculus	46-50
23029429-5	2012	After having identified the acetyltransferase p300 among several acetyltransferases to be associated with Rb2/p130 during S-phase in NIH3T3 cells in vivo, we used this enzyme and the CDK4 protein kinase for in vitro modification of a variety of full length Rb2/p130 and truncated versions with mutations in the acetylatable lysine residues 1079, 128 and 130.	Lysine	324-330	RB transcriptional corepressor like 2	Mus musculus	106-109
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	nuclear receptor coactivator 3	Mus musculus	203-208
31914406-6	2020	We note that enrichment of NCOA3, which has histone acetyltransferase activity, is associated with histone 3 Lys-27 acetylation (H3K27ac) at the LPAR6 locus in response to HGF treatment, indicating that NCOA3 transcriptionally regulates LPAR6 through the HGF signaling cascade.	Lysine	109-112	hepatocyte growth factor	Mus musculus	255-258
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Lysine	15-22	RB transcriptional corepressor like 2	Mus musculus	73-76
20837706-1	2010	MOF (MYST1) is the major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution.	Lysine	70-76	K(lysine) acetyltransferase 8	Mus musculus	5-10
31320749-6	2020	We further found that PVT1 serves as a scaffold for the chromatin modification factor KAT2A, which mediates histone 3 lysine 9 acetylation (H3K9), recruiting the nuclear receptor binding protein TIF1beta to activate NF90 transcription, thereby increasing HIF-1alpha stability and promoting a malignant phenotype in NPC cells.	Lysine	118-124	lysine acetyltransferase 2A	Homo sapiens	86-91
20810545-7	2010	Accordingly, chromatin immunoprecipitation analysis shows that sdg8-1 impairs dynamic changes of histone H3 lysine 36 methylation at defense marker genes as well as at MKK3 and MKK5, which normally occurs upon infection with fungal pathogens or methyl JA treatment in wild-type plants.	Lysine	108-114	histone-lysine N-methyltransferase	Arabidopsis thaliana	63-67
22723905-9	2012	The two ncRNAs could therefore help to protect the paternal allele from DNA methylation by attracting Trithorax proteins that mediate H3 lysine-4 methylation.	Lysine	137-143	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	102-111
20810545-8	2010	Our data indicate that SDG8-mediated histone H3 lysine 36 methylation may serve as a memory of permissive transcription for a subset of defense genes, allowing rapid establishment of transcriptional induction.	Lysine	48-54	histone-lysine N-methyltransferase	Arabidopsis thaliana	23-27
31756401-1	2020	G9a (also known as EHMT2 - Euchromatin histone methyltransferase 2) is a protein lysine methyltransferase which introduces methylation modification in variety of proteins including histones.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
31756401-1	2020	G9a (also known as EHMT2 - Euchromatin histone methyltransferase 2) is a protein lysine methyltransferase which introduces methylation modification in variety of proteins including histones.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	19-24
20817729-6	2010	Tandem mass spectrometry and mutagenesis studies revealed that SREBP-1c is acetylated by p300 at Lys-289 and Lys-309.	Lysine	97-100	sterol regulatory element binding transcription factor 1	Mus musculus	63-71
31756401-2	2020	G9a catalyzes the dimethylation of lysine 9 on histone 3 (H3K9me2) which is a repressive epigenetic modification.	Lysine	35-41	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
22574209-2	2012	Of the enzymes that mediate post-translation modifications, the GCN5 of the histone acetyltransferase (HAT) proteins family that add acetyl groups to target lysine residues within histones, has been most extensively studied.	Lysine	157-163	lysine acetyltransferase 2A	Homo sapiens	64-68
22685397-5	2012	P. gingivalis-induced cleavage of RIPK1 and RIPK2 was inhibited in the presence of a lysine-specific gingipain (Kgp) inhibitor.	Lysine	85-91	receptor interacting serine/threonine kinase 2	Homo sapiens	44-49
31957467-13	2020	Mechanistically, Ahit directly bound and recruited SUZ12, a core PRC2 (polycomb repressive complex 2) protein, to the promoter of MEF2A, triggering its trimethylation on H3 lysine 27 (H3K27me3) residues and mediating the downregulation of MEF2A, thereby preventing cardiac hypertrophy.	Lysine	173-179	myocyte enhancer factor 2A	Mus musculus	130-135
31957467-13	2020	Mechanistically, Ahit directly bound and recruited SUZ12, a core PRC2 (polycomb repressive complex 2) protein, to the promoter of MEF2A, triggering its trimethylation on H3 lysine 27 (H3K27me3) residues and mediating the downregulation of MEF2A, thereby preventing cardiac hypertrophy.	Lysine	173-179	myocyte enhancer factor 2A	Mus musculus	239-244
22072716-3	2011	Representative enzymes from this group, Ubp15 from yeast and its human ortholog USP7, rapidly remove mono- and diubiquitin from substrates but are slow to remove longer Lys(48)-linked chains.	Lysine	169-172	ubiquitin specific peptidase 7	Homo sapiens	80-84
20817729-6	2010	Tandem mass spectrometry and mutagenesis studies revealed that SREBP-1c is acetylated by p300 at Lys-289 and Lys-309.	Lysine	109-112	sterol regulatory element binding transcription factor 1	Mus musculus	63-71
21060799-3	2010	Here, we report studies to test the involvement of Jumonji domain-containing protein 6 (Jmjd6) in histone lysine demethylation.	Lysine	106-112	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	51-86
22103349-7	2011	Experiments using ubiquitin mutants demonstrated that the XIAP-dependent ubiquitin linkage was not formed through the commonly used lysine 48, suggesting a noncanonical ubiquitin linkage is employed.	Lysine	132-138	X-linked inhibitor of apoptosis	Homo sapiens	58-62
22103349-8	2011	Further studies demonstrated that only lysine 255 of AIF was a target of XIAP-dependent ubiquitination.	Lysine	39-45	apoptosis inducing factor mitochondria associated 1	Homo sapiens	53-56
21060799-3	2010	Here, we report studies to test the involvement of Jumonji domain-containing protein 6 (Jmjd6) in histone lysine demethylation.	Lysine	106-112	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	88-93
22103349-9	2011	Using recombinant AIF, we determined that mutating lysine 255 of AIF interferes with the ability of AIF not only to bind DNA but also to degrade chromatin in vitro.	Lysine	51-57	apoptosis inducing factor mitochondria associated 1	Homo sapiens	18-21
21060799-9	2010	A comparison of mono-, di-, and tri-methylation states of H3K4, H3K9, H3K27, H3K36, and H4K20 histone residues in wildtype and Jmjd6-knockout cells indicate that Jmjd6 is not involved in the demethylation of these histone lysine residues.	Lysine	222-228	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	127-132
22103349-9	2011	Using recombinant AIF, we determined that mutating lysine 255 of AIF interferes with the ability of AIF not only to bind DNA but also to degrade chromatin in vitro.	Lysine	51-57	apoptosis inducing factor mitochondria associated 1	Homo sapiens	65-68
22103349-9	2011	Using recombinant AIF, we determined that mutating lysine 255 of AIF interferes with the ability of AIF not only to bind DNA but also to degrade chromatin in vitro.	Lysine	51-57	apoptosis inducing factor mitochondria associated 1	Homo sapiens	65-68
21060834-0	2010	Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.	Lysine	64-70	chromobox 7	Homo sapiens	9-13
33554132-4	2020	BRPF1 is known to recruit the MOZ HAT complex to chromatin by recognizing acetylated lysine residues on the N-terminal histone tail region through its bromodomain.	Lysine	85-91	bromodomain and PHD finger containing 1	Homo sapiens	0-5
20675860-0	2010	SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.	Lysine	75-81	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
31576013-7	2020	Further investigation revealed that SIRT1 deacetylates and stabilizes GLI2 protein at lysine 757 and consequentially activates the Hh signaling, and itself serves as a direct target of Hh signaling to format a positive regulating loop.	Lysine	86-92	sirtuin 1	Homo sapiens	36-41
21965678-5	2011	SUMO conjugation on Lys-509, which is located within the SUMO consensus site, together with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, probably by recruiting HDAC2 onto the PS2 promoter.	Lysine	20-23	metastasis associated 1	Homo sapiens	151-155
22128329-4	2011	We now show that TRIM27 functions as an E3 ligase and mediates lysine 48 polyubiquitination of PI3KC2beta, leading to a decrease in PI3K enzyme activity.	Lysine	63-69	tripartite motif containing 27	Homo sapiens	17-23
20950777-9	2010	JDP2 inhibits recruitment of the polycomb repressive complexes 1 and 2 (PRC-1 and PRC-2) to the promoter of the gene that encodes p16(Ink4a) and inhibits the methylation of lysine 27 of histone H3 (H3K27).	Lysine	173-179	Jun dimerization protein 2	Homo sapiens	0-4
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Lysine	38-41	angiotensin-converting enzyme	Oryctolagus cuniculus	153-156
31842816-4	2019	RESULTS: Among the cases (n = 190), the median levels of AF biomarker, serum AFB1-lysine adduct, and FN biomarker, urinary FB1, were 1.77 pg/mg albumin and 176.13 pg/mg creatinine, respectively.	Lysine	82-88	TCF3 fusion partner	Homo sapiens	78-81
31842816-5	2019	Among the controls (n = 380), the median levels of AFB1-lysine adduct and urinary FB1 were 1.49 pg/mg albumin and 56.92 pg/mg creatinine, respectively.	Lysine	56-62	TCF3 fusion partner	Homo sapiens	52-55
22199132-4	2011	The k(cat)/K(m) values of Nma-Phe-His-Lys(Dnp), Nma-His-Pro-Phe-Lys(Dnp)-Pro, and Hip-His-Leu were 5.12, 1.90, and 0.80 microM(-1) s(-1) for rabbit lung ACE, and 16.0, 7.36, and 0.30 microM(-1) s(-1) for recombinant human (rh)-ACE, respectively.	Lysine	64-67	angiotensin-converting enzyme	Oryctolagus cuniculus	153-156
20930491-2	2010	We previously obtained a crosslinked product when Lys(28) of the cysteine-less form of human galectin-1 was mutated to cysteine.	Lysine	50-53	galectin 1	Homo sapiens	93-103
31666337-9	2019	LC-MS/MS analysis revealed that Lys-12, Lys-23, Lys-96, and Lys-226 in apoA-I are modified by ONE ketoamide adducts.	Lysine	32-35	apolipoprotein A-I	Mus musculus	71-77
31666337-9	2019	LC-MS/MS analysis revealed that Lys-12, Lys-23, Lys-96, and Lys-226 in apoA-I are modified by ONE ketoamide adducts.	Lysine	40-43	apolipoprotein A-I	Mus musculus	71-77
21952235-4	2011	Using chromatin immunoprecipitation analysis, we reveal that Sirt1 directly and negatively regulates Sost gene expression by deacetylating histone 3 at lysine 9 at the Sost promoter.	Lysine	152-158	sclerostin	Mus musculus	101-105
20581860-5	2010	We also found that WDR5, an adaptor protein essential for lysine 4 trimethylation of histone H3 (H3K4me3) by MLL, colocalizes and interacts with MOZ.	Lysine	58-64	lysine methyltransferase 2A	Homo sapiens	109-112
21952235-4	2011	Using chromatin immunoprecipitation analysis, we reveal that Sirt1 directly and negatively regulates Sost gene expression by deacetylating histone 3 at lysine 9 at the Sost promoter.	Lysine	152-158	sclerostin	Mus musculus	168-172
31666337-9	2019	LC-MS/MS analysis revealed that Lys-12, Lys-23, Lys-96, and Lys-226 in apoA-I are modified by ONE ketoamide adducts.	Lysine	40-43	apolipoprotein A-I	Mus musculus	71-77
31666337-9	2019	LC-MS/MS analysis revealed that Lys-12, Lys-23, Lys-96, and Lys-226 in apoA-I are modified by ONE ketoamide adducts.	Lysine	40-43	apolipoprotein A-I	Mus musculus	71-77
31694912-8	2019	Using an RGR variant, K255A, we confirmed that a Schiff base linkage at Lys-255 is critical for substrate binding and isomerization.	Lysine	72-75	retinal G protein coupled receptor	Mus musculus	9-12
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	74-80	small ubiquitin like modifier 3	Homo sapiens	157-162
31752909-8	2019	Although AR sumoylation occurs prior to ubiquitination, the SUMO-acceptor lysine 386 on AR, together with ubiquitin-acceptor lysine 845, contribute to PIAS1/SUMO3-induced AR nuclear export, ubiquitination and subsequent degradation.	Lysine	125-131	small ubiquitin like modifier 3	Homo sapiens	157-162
21925125-7	2011	RESULTS: We found that CD44 binds directly to HER2, which up-regulates the expression of metastasis-associated protein-1, induces deacetylation of histone H3 lysine 9, and suppresses transcription of microRNA139 (miR-139) to inhibit expression of its target gene, C-X-C chemokine receptor type 4 (CXCR4).	Lysine	158-164	CD44 molecule (Indian blood group)	Homo sapiens	23-27
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	PR/SET domain 2	Homo sapiens	170-173
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	signal transducer and activator of transcription 1	Homo sapiens	290-295
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	297-304
20581860-5	2010	We also found that WDR5, an adaptor protein essential for lysine 4 trimethylation of histone H3 (H3K4me3) by MLL, colocalizes and interacts with MOZ.	Lysine	58-64	lysine acetyltransferase 6A	Homo sapiens	145-148
20957523-2	2011	It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including several oncogenes (e.g., N-myc, CrkL, Wnt10b, RIZ and hTERT) and genes involved in the control of cell cycle (e.g., CyclinG1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11 and PIK3CB).	Lysine	44-50	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	309-315
21931165-1	2011	CYLD is a lysine 63-deubiquitinating enzyme that inhibits NF-kappaB and JNK signaling.	Lysine	10-16	mitogen-activated protein kinase 8	Mus musculus	72-75
20567816-7	2010	Analysis of the cleavage site of N-terminally truncated Dga1p revealed a major site between Lys-29 and Ser-30.	Lysine	92-95	diacylglycerol O-acyltransferase	Saccharomyces cerevisiae S288C	56-61
21642490-10	2011	A reduction in dietary Lys concentration decreased ADG (P = 0.004) and ADFI (P = 0.001) in pigs.	Lysine	23-26	ADG	Sus scrofa	51-54
31693890-3	2019	Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1).	Lysine	88-94	lysine demethylase 1A	Homo sapiens	188-217
31693890-3	2019	Here, we show that SET and MYND domain containing 2 (SMYD2) directly methylates EZH2 at lysine 307 (K307) and enhances its stability, which can be relieved by the histone H3K4 demethylase lysine-specific demethylase 1 (LSD1).	Lysine	88-94	lysine demethylase 1A	Homo sapiens	219-223
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	85-91	lysyl oxidase	Homo sapiens	0-3
20684045-5	2010	MS2 strongly supports that lysine is added to the 5-position during the formation of guanidinohydantoin-lysine.	Lysine	27-33	MS2	Homo sapiens	0-3
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	127-133	lysyl oxidase	Homo sapiens	0-3
31504232-4	2019	LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins.	Lysine	127-133	lysyl oxidase	Homo sapiens	0-3
31450981-5	2019	Given the reduced cell number in Sin3a-depleted embryos, blocked cell proliferation is observed, likely because of the increased level of Trp53 acetylation at lysine 379.	Lysine	159-165	transcriptional regulator, SIN3A (yeast)	Mus musculus	33-38
22014533-4	2011	Using chromatin immunoprecipitation (ChIP) microarray data, we identified markedly increased histone H3 lysine 27 trimethylation (H3K27me3) enrichment at the HPK1 promoter of SLE CD4+ T cells relative to controls, and confirmed this observation using ChIP and real-time PCR experiments.	Lysine	104-110	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	158-162
21875999-1	2011	Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and Drosophila melanogaster Trithorax (Trx).	Lysine	26-32	trithorax	Drosophila melanogaster	223-226
20606006-8	2010	In addition, we identify five lysine residues (K180, K182, K183, K188, and K193) immediately downstream of the Xic1 PIP box and within the second Cdt2 binding domain as critical sites for Xic1 ubiquitination.	Lysine	30-36	cyclin-dependent kinase inhibitor xic1 L homeolog	Xenopus laevis	111-115
22001918-4	2011	The influence of arginine monomethylation in histone H3 on the acetylation of lysine residues by histone acetyltransferase hGCN5 was investigated, and the results demonstrated that K9 acetylation was suppressed by the methylation of R8 and R17 but not by R26 methylation.	Lysine	78-84	lysine acetyltransferase 2A	Homo sapiens	123-128
21900231-7	2011	Superposition of the ternary Naa50p complex with the peptide-bound Gcn5 histone acetyltransferase revealed that the two enzymes share a Gcn5-related N-acetyltransferase fold but differ in their respective substrate-binding grooves such that Naa50p can accommodate only an alpha-amino substrate and not a side chain lysine substrate that is acetylated by lysine acetyltransferase enzymes such as Gcn5.	Lysine	315-321	lysine acetyltransferase 2A	Homo sapiens	67-71
31500447-7	2019	Furthermore, nicotine induced histone acetylase p300 into the nuclei of the BMSCs by acting on the alpha4beta2-nicotinic acetylcholine receptor (alpha4beta2-nAChR), leading to the increased histone 3 lysine 9 acetylation level of ACE and RAS activation.	Lysine	200-206	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	157-162
20606006-8	2010	In addition, we identify five lysine residues (K180, K182, K183, K188, and K193) immediately downstream of the Xic1 PIP box and within the second Cdt2 binding domain as critical sites for Xic1 ubiquitination.	Lysine	30-36	cyclin-dependent kinase inhibitor xic1 L homeolog	Xenopus laevis	188-192
31070797-8	2019	Chromatin immunoprecipitation assays identified an FN promoter element in which EZH2-mediated tri-methylation of lysine 27 on histone 3 is diminished by TGF-beta.	Lysine	113-119	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	80-84
21846128-9	2011	In particular, an ionizable active site lysine and aspartate are present in all SDH homologues.	Lysine	40-46	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	80-83
20510667-9	2010	We suggest that YHL039W (now designated EFM1 for elongation factor methyltransferase 1) and YIL064W/SEE1 encode distinct eEF1A methyltransferases that respectively monomethylate and dimethylate this protein at lysine residues.	Lysine	210-216	Efm4p	Saccharomyces cerevisiae S288C	100-104
21889916-2	2011	The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases.	Lysine	89-95	proliferating cell nuclear antigen	Mus musculus	81-85
21889916-2	2011	The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases.	Lysine	89-95	proliferating cell nuclear antigen	Mus musculus	101-105
31265113-5	2019	Dietary Lys level had a linear (P &lt; 0.05) and quadratic (P &lt; 0.05) effects on maternal hepatic expression of mechanistic target of rapamycin, eukaryotic translation initiation factor 4E binding protein 1, ubiquitin conjugating enzyme E2K (UBE2K), cathepsin B (CTSB), and quadratically (P &lt; 0.05) increased the concentrations of plasma Lys, leucine, threonine, and tryptophan in duck breeders.	Lysine	8-11	cathepsin B	Homo sapiens	253-264
31265113-5	2019	Dietary Lys level had a linear (P &lt; 0.05) and quadratic (P &lt; 0.05) effects on maternal hepatic expression of mechanistic target of rapamycin, eukaryotic translation initiation factor 4E binding protein 1, ubiquitin conjugating enzyme E2K (UBE2K), cathepsin B (CTSB), and quadratically (P &lt; 0.05) increased the concentrations of plasma Lys, leucine, threonine, and tryptophan in duck breeders.	Lysine	8-11	cathepsin B	Homo sapiens	266-270
31265113-6	2019	In contrast, maternal dietary Lys suppressed expression of proteasome 26S subunit, UBE2K, and CTSB in the liver of hatchlings.	Lysine	30-33	cathepsin B	Homo sapiens	94-98
20558726-6	2010	The N-terminal part of BCL-3 includes lysines 13 and 26 required for the Lys(48)-linked polyubiquitination of BCL-3.	Lysine	38-45	BCL3 transcription coactivator	Homo sapiens	23-28
21845278-1	2011	STM imaging following the adsorption of (S)-lysine on Au{111} leads to the observation of Au nanofingers whose growth directions correlate with the unit cell vectors of ordered 2-D phases of lysine.	Lysine	40-50	sulfotransferase family 1A member 3	Homo sapiens	0-3
21845278-1	2011	STM imaging following the adsorption of (S)-lysine on Au{111} leads to the observation of Au nanofingers whose growth directions correlate with the unit cell vectors of ordered 2-D phases of lysine.	Lysine	44-50	sulfotransferase family 1A member 3	Homo sapiens	0-3
31366618-2	2019	Here, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide phosphoribosyltransferase (NAMPT)/sirtuin 2 (SIRT2) pathway.	Lysine	64-70	LIM domain only 2	Homo sapiens	26-30
20558726-6	2010	The N-terminal part of BCL-3 includes lysines 13 and 26 required for the Lys(48)-linked polyubiquitination of BCL-3.	Lysine	38-45	BCL3 transcription coactivator	Homo sapiens	110-115
20558726-6	2010	The N-terminal part of BCL-3 includes lysines 13 and 26 required for the Lys(48)-linked polyubiquitination of BCL-3.	Lysine	73-76	BCL3 transcription coactivator	Homo sapiens	23-28
22067432-4	2011	One such histone mark critical for maintaining chromatin structure is acetylated lysine 16 of histone H4 (AcH4K16), a modification that can disrupt higher order chromatin organization and convert it into a more "relaxed" configuration.	Lysine	81-87	LOC102641229	Mus musculus	94-104
20558726-6	2010	The N-terminal part of BCL-3 includes lysines 13 and 26 required for the Lys(48)-linked polyubiquitination of BCL-3.	Lysine	73-76	BCL3 transcription coactivator	Homo sapiens	110-115
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Lysine	4-10	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	110-131
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Lysine	4-10	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	133-138
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	25-31	CDK2 associated cullin domain 1	Homo sapiens	37-43
31408067-2	2019	The lysine-proline-valine (KPV) tripeptide, which possesses anti-inflammatory properties and high affinity to peptide transporter 1 (PepT1), can target therapy-related cells (colonic epithelial cells and macrophages) via overexpression of PepT1.	Lysine	4-10	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	239-244
21756203-4	2011	In particular, it is directly acetylated by the HAT enzyme general control nonderepressible 5 (GCN5), resulting in a transcriptionally inactive protein that relocalizes from promoter regions to nuclear foci, whereas it is deacetylated by SIRT1 at multiple lysine sites, with a subsequent increase in its activity leading to induction of liver gluconeogenic gene transcription.	Lysine	256-262	lysine acetyltransferase 2A	Homo sapiens	59-93
21756203-4	2011	In particular, it is directly acetylated by the HAT enzyme general control nonderepressible 5 (GCN5), resulting in a transcriptionally inactive protein that relocalizes from promoter regions to nuclear foci, whereas it is deacetylated by SIRT1 at multiple lysine sites, with a subsequent increase in its activity leading to induction of liver gluconeogenic gene transcription.	Lysine	256-262	lysine acetyltransferase 2A	Homo sapiens	95-99
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	25-31	interleukin 31 receptor A	Homo sapiens	109-112
21756203-4	2011	In particular, it is directly acetylated by the HAT enzyme general control nonderepressible 5 (GCN5), resulting in a transcriptionally inactive protein that relocalizes from promoter regions to nuclear foci, whereas it is deacetylated by SIRT1 at multiple lysine sites, with a subsequent increase in its activity leading to induction of liver gluconeogenic gene transcription.	Lysine	256-262	sirtuin 1	Homo sapiens	238-243
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	166-172	CDK2 associated cullin domain 1	Homo sapiens	37-43
30933372-3	2019	Using analysis of genome-wide histone modifications, DNA methylation, and hydroxymethylation in mouse hepatocytes, we show that HNF4A occupies active enhancers in hepatocytes and is essential for active histone and DNA signatures, especially acetylation of lysine 27 of histone 3 (H3K27ac) and 5-hydroxymethylcytosine (5hmC).	Lysine	257-263	hepatic nuclear factor 4, alpha	Mus musculus	128-133
21750091-6	2011	We also showed that cell lines with over-expression of EVI1 had no DNA methylation in the promoter region of the EVI1 locus, and had marks of active histone modifications: H3 and H4 acetylation, and trimethylation of histone H3 lysine 4.	Lysine	228-234	MDS1 and EVI1 complex locus	Homo sapiens	55-59
21750091-7	2011	Conversely, cell lines with no expression of EVI1 have DNA hypermethylation and are marked by repressive trimethylation of histone H3 lysine 27 at the EVI1 promoter.	Lysine	134-140	MDS1 and EVI1 complex locus	Homo sapiens	45-49
20682250-6	2010	Furthermore, mutation of lysine, the cullin residue to which NEDD8 covalently attaches, dramatically reduces CRL conformational changes, suggesting that the acceptor lysine allosterically regulates CRLs.	Lysine	166-172	interleukin 31 receptor A	Homo sapiens	109-112
21750091-7	2011	Conversely, cell lines with no expression of EVI1 have DNA hypermethylation and are marked by repressive trimethylation of histone H3 lysine 27 at the EVI1 promoter.	Lysine	134-140	MDS1 and EVI1 complex locus	Homo sapiens	151-155
21750091-9	2011	Furthermore, we demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation of histone H3 lysine 4 and histone H3 lysine 27 might play a role in the transcriptional regulation of EVI1 in acute myeloid leukemia.	Lysine	167-173	MDS1 and EVI1 complex locus	Homo sapiens	256-260
20682250-7	2010	Thus, our results imply that neddylation stimulates ubiquitination by CRL conformational control via lysine modification.	Lysine	101-107	interleukin 31 receptor A	Homo sapiens	70-73
20357812-5	2010	Chromatin immunoprecipitation assays revealed enrichment of acetylated histones H3 and H4, and H3 di- and tri-methylated lysine 4 on the unmethylated IGFBP3 promoter.	Lysine	121-127	insulin like growth factor binding protein 3	Homo sapiens	150-156
21740978-11	2011	(2) The distance between the SXXK-motif Lys-NZ atom and the Lys/His-nitrogen atom of the (K/H)T(S)G-motif was highly conserved, suggesting importance for PBP function, and a possibly conserved role in the catalytic mechanism of the PBPs.	Lysine	40-43	phosphatidylethanolamine binding protein 1	Homo sapiens	154-157
21740978-11	2011	(2) The distance between the SXXK-motif Lys-NZ atom and the Lys/His-nitrogen atom of the (K/H)T(S)G-motif was highly conserved, suggesting importance for PBP function, and a possibly conserved role in the catalytic mechanism of the PBPs.	Lysine	60-63	phosphatidylethanolamine binding protein 1	Homo sapiens	154-157
31377725-6	2019	PKL interacts with ATX1 to mediate trimethylation of histone H3 on lysine 4 (H3K4me3) at the FT locus, leading to antagonistic effects of PKL and ATX1 on PcG proteins in the regulation of FT expression.	Lysine	67-73	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	0-3
31377725-6	2019	PKL interacts with ATX1 to mediate trimethylation of histone H3 on lysine 4 (H3K4me3) at the FT locus, leading to antagonistic effects of PKL and ATX1 on PcG proteins in the regulation of FT expression.	Lysine	67-73	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	138-141
31291457-5	2019	At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR.	Lysine	94-100	sirtuin 1	Homo sapiens	30-35
31291457-5	2019	At DNA damage sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stimulating its ATPase activity to remodel chromatin and promote HR.	Lysine	94-100	sirtuin 1	Homo sapiens	67-72
20510245-2	2010	Homocysteine thiolactone is a cyclic thioester, most of which is produced by an error-editing function of methionyl-tRNA synthetase, causing in vivo post-translational protein modifications by reacting with the epsilon-amino group of lysine residues.	Lysine	234-240	methionyl-tRNA synthetase 1	Homo sapiens	106-131
21791417-3	2011	Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential.	Lysine	39-45	chromosome 20 open reading frame 181	Homo sapiens	9-12
21791417-3	2011	Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential.	Lysine	39-45	chromosome 20 open reading frame 181	Homo sapiens	200-203
31184779-0	2019	BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination.	Lysine	108-114	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	0-40
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Lysine	30-36	telomerase reverse transcriptase	Homo sapiens	3-8
31218831-12	2019	KDM2B is acetylated at lysine 758 by Tip60 in human osteosarcoma cells.	Lysine	23-29	lysine acetyltransferase 5	Homo sapiens	37-42
31326165-11	2019	Our results indicate that casein synthesis was regulated by Lys/Met ratio via JAK2/ELF5, mTOR, and its downstream RPS6KB1 and EIF4EBP1 signaling.	Lysine	60-63	E74 like ETS transcription factor 5	Bos taurus	83-87
21884927-1	2011	Histone H3 lysine 4 trimethylation needed for transcription is mediated by the Set1 methyltransferase and requires prior monoubiquitination of histone H2B.	Lysine	11-17	histone H2B	Saccharomyces cerevisiae S288C	143-154
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	activating transcription factor 5	Homo sapiens	25-29
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	activating transcription factor 5	Homo sapiens	100-104
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	activating transcription factor 5	Homo sapiens	100-104
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	activating transcription factor 5	Homo sapiens	100-104
21791614-2	2011	We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) region of the Egr-1 promoter.	Lysine	108-114	activating transcription factor 5	Homo sapiens	100-104
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	activating transcription factor 5	Homo sapiens	10-14
21791614-3	2011	ARE-bound ATF5/p300 acetylates lysine-14 (K14) of nucleosomal histone H3 at both the ARE and serum response element (SRE) of the Egr-1 promoter, which facilitates binding of extracellular signal-regulated kinase (ERK)-phosphorylated Elk-1 to the SRE, activating the Egr-1 promoter.	Lysine	31-37	ETS transcription factor ELK1	Homo sapiens	233-238
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	95-101	MDM2 proto-oncogene	Homo sapiens	27-31
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	111-114	MDM2 proto-oncogene	Homo sapiens	27-31
21628454-5	2011	Upon nuclear accumulation, HDM2 targets unphosphorylated NFATc2 for ubiquitination at acceptor lysine residues Lys-684/Lys-897 and hence labels the factor for subsequent proteasomal degradation.	Lysine	119-122	MDM2 proto-oncogene	Homo sapiens	27-31
31350355-2	2019	A specific genetic variation in SP-A2, corresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 of the lectin domain, was shown to alter the ability of SP-A to inhibit eosinophil degranulation.	Lysine	75-81	surfactant protein A2	Homo sapiens	32-37
31350355-2	2019	A specific genetic variation in SP-A2, corresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 of the lectin domain, was shown to alter the ability of SP-A to inhibit eosinophil degranulation.	Lysine	75-81	surfactant protein A2	Homo sapiens	32-36
21808001-4	2011	Next, MSK1 and Elk-1 activation evoked serine-10 phosphorylation and lysine-14 acetylation in histone H3, resulting in the induction of the neuroplasticity-associated immediate-early genes c-Fos and Egr-1 in these neurons.	Lysine	69-75	ETS transcription factor ELK1	Homo sapiens	15-20
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Lysine	30-36	telomerase reverse transcriptase	Homo sapiens	67-72
21808001-4	2011	Next, MSK1 and Elk-1 activation evoked serine-10 phosphorylation and lysine-14 acetylation in histone H3, resulting in the induction of the neuroplasticity-associated immediate-early genes c-Fos and Egr-1 in these neurons.	Lysine	69-75	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-194
20408817-4	2010	In the present study we show that XBP1s, the active spliced form of XBP1 protein, is SUMOylated, mainly by PIAS2 [protein inhibitor of activated STAT (signal transducer and activator of transcription) 2] at two lysine residues located in the C-terminal transactivation domain.	Lysine	211-217	X-box binding protein 1	Homo sapiens	34-38
21541786-1	2011	Alternative lysine and methionine residues at position 44 in the D1 domain determine the specificities of human lineage III killer cell immunoglobulin-like receptors (KIR) for the C1 and C2 epitopes of HLA-C.	Lysine	12-18	major histocompatibility complex, class I, C	Homo sapiens	202-207
31555266-10	2019	Interestingly, 2 of these 4 sites were also hypermethylated in the continuous exposure group, and both of these island regions are associated with lysine 27 on histone H3 (H3K27) involved in polycomb complex-dependent transcriptional repression via H3K27 tri-methylation.	Lysine	147-153	chromobox 2	Mus musculus	191-199
20388717-8	2010	We identified 14 sumoylation sites, including well known sites, such as Lys(524) of RanGAP1, and novel non-consensus sites.	Lysine	72-75	Ran GTPase activating protein 1	Homo sapiens	84-91
31315929-9	2019	Finally, we determined ATG3 residue Lys-243 as an LC3B modification site.	Lysine	36-39	autophagy related 3	Homo sapiens	23-27
21680712-1	2011	In Saccharomyces cerevisiae, ubiquitylation of histone H2B signals methylation of histone H3 at lysine residues 4 (K4) and 79.	Lysine	96-102	histone H2B	Saccharomyces cerevisiae S288C	47-58
21847359-7	2011	Importantly, we show that EHMT2 can suppress transcription of the SIAH1 gene by binding to its promoter region (-293 to +51) and by methylating lysine 9 of histone H3.	Lysine	144-150	euchromatic histone lysine methyltransferase 2	Homo sapiens	26-31
20483773-2	2010	K3 recruits the cellular E2 ubiquitin-conjugating enzyme Ubc13 to generate lysine-63-linked polyubiquitin chains on MHC I, leading to the clathrin-mediated endocytosis and lysosomal degradation of MHC I.	Lysine	75-81	ubiquitin conjugating enzyme E2 N	Homo sapiens	57-62
20033197-1	2010	Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin.	Lysine	68-74	chromobox 5	Homo sapiens	0-25
21876682-5	2011	First, functional loss of key epigenetic genes-including METHYLTRANSFERASE1 (MET1) encoding for DNA methyltransferase, KRYPTONITE (KYP) for the histone 3 lysine 9 (H3K9) methyltransferase, JMJ14 for the histone 3 lysine 4 (H3K4) demethylase, and HAC1 for the histone acetyltransferase-resulted in altered WUS expression and developmental rates of regenerated shoots in vitro.	Lysine	154-160	methyltransferase 1	Arabidopsis thaliana	77-81
22567190-0	2011	Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2"-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents.	Lysine	55-61	microRNA 122	Homo sapiens	44-51
31229693-7	2019	In particular, the sites with the most significant downregulation of lysine 2-hydroxyisobutyrylation were found in S100A9 (ratio = 0.140, p-value = .000371), while the most upregulated site was found in tenascin (ratio = 3.082, p-value = .0307).	Lysine	69-75	S100 calcium binding protein A9	Homo sapiens	115-121
31409866-2	2019	E3 ubiquitin ligase complexes facilitate the post-translational addition of ubiquitin, which based on the quantity and specific lysine linkages, results in different outcomes.	Lysine	128-134	Ubiquitin	Caenorhabditis elegans	3-12
31409866-2	2019	E3 ubiquitin ligase complexes facilitate the post-translational addition of ubiquitin, which based on the quantity and specific lysine linkages, results in different outcomes.	Lysine	128-134	Ubiquitin	Caenorhabditis elegans	76-85
20033197-1	2010	Heterochromatin protein 1 (HP1), which binds to sites of histone H3 lysine 9 (H3K9) methylation, is primarily responsible for gene silencing and the formation of heterochromatin.	Lysine	68-74	chromobox 5	Homo sapiens	27-30
20698772-8	2010	In addition, chromatin immunoprecipitation assay revealed that histone H3 is highly acetylated, and H3 lysine (K) 4 is hypermethylated at the Nanog locus and the Oct-4 locus in hESCs grown on hAECs.	Lysine	103-109	POU class 5 homeobox 1	Homo sapiens	162-167
31096156-1	2019	Lysine-specific demethylase 1 (LSD1), demethylase against mono- and di - methylated histone3 lysine 4, has emerged as a promising target in oncology.	Lysine	93-99	lysine demethylase 1A	Homo sapiens	0-29
31096156-1	2019	Lysine-specific demethylase 1 (LSD1), demethylase against mono- and di - methylated histone3 lysine 4, has emerged as a promising target in oncology.	Lysine	93-99	lysine demethylase 1A	Homo sapiens	31-35
21565980-3	2011	SIRT1, the main member of the sirtuin family, inactivates p53 by deacetylating a critical lysine residue.	Lysine	90-96	sirtuin 1	Homo sapiens	0-5
21566084-5	2011	Maximal binding of GATA4 precedes ERalpha binding, and GATA4 is necessary for histone 3 lysine 4 dimethylation at ERalpha binding sites, suggesting that GATA4 is a pioneer factor for ERalpha.	Lysine	88-94	GATA binding protein 4	Homo sapiens	55-60
21566084-5	2011	Maximal binding of GATA4 precedes ERalpha binding, and GATA4 is necessary for histone 3 lysine 4 dimethylation at ERalpha binding sites, suggesting that GATA4 is a pioneer factor for ERalpha.	Lysine	88-94	GATA binding protein 4	Homo sapiens	55-60
21576370-1	2011	The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of STAT1 at lysine 410 and lysine 413 (O. H. Kramer et al., Genes Dev.	Lysine	118-124	signal transducer and activator of transcription 1	Homo sapiens	109-114
30793225-7	2019	GPNMB could upregulate the expression of Jumonji domain-containing protein 3 (Jmjd3), a histone 3 lysine 27 (H3K27) demethylase that is linked to the modulation of the inflammatory response and apoptosis.	Lysine	98-104	lysine demethylase 6B	Homo sapiens	41-76
20368352-7	2010	Mechanistically, ATDC binds p53, and this interaction is potentially fine-tuned by posttranslational acetylation of lysine 116 on ATDC.	Lysine	116-122	tripartite motif containing 29	Homo sapiens	17-21
30793225-7	2019	GPNMB could upregulate the expression of Jumonji domain-containing protein 3 (Jmjd3), a histone 3 lysine 27 (H3K27) demethylase that is linked to the modulation of the inflammatory response and apoptosis.	Lysine	98-104	lysine demethylase 6B	Homo sapiens	78-83
21576370-9	2011	We conclude that the effects and potential clinical benefits associated with histone deacetylase inhibition cannot be explained by promoting the acetylation of STAT1 at lysines 410 and 413.	Lysine	169-176	signal transducer and activator of transcription 1	Homo sapiens	160-165
21388379-6	2011	Here, we demonstrate that NtUBP12 and AtUBP12 are bona fide deubiquitinating enzymes capable of cleaving lysine-48-linked ubiquitin chains.	Lysine	105-111	ubiquitin carboxyl-terminal hydrolase 12-like	Nicotiana tabacum	26-33
21515688-8	2011	Homology modeling and mutagenesis identified a cluster of basic amino acid residues (Lys(51), Arg(56), and Arg(80)) on the surface of human CTRC that interact with the P4" acidic residue of the inhibitor.	Lysine	85-88	chymotrypsin C	Homo sapiens	140-144
20368352-7	2010	Mechanistically, ATDC binds p53, and this interaction is potentially fine-tuned by posttranslational acetylation of lysine 116 on ATDC.	Lysine	116-122	tripartite motif containing 29	Homo sapiens	130-134
21521686-9	2011	We propose that Lys-537(mBMAL1) acetylation enhances mCRY1 binding by affecting electrostatic interactions predominantly with the mCRY1 tail.	Lysine	16-19	cryptochrome 1 (photolyase-like)	Mus musculus	53-58
20309721-4	2010	Metnase methylates histone H3 lysine 36 (H3K36), improves the integration of foreign DNA, and enhances DNA double-strand break (DSB) repair by the non-homologous end joining (NHEJ) pathway, potentially dependent on its interaction with DNA Ligase IV.	Lysine	30-36	DNA ligase 4	Homo sapiens	236-249
21521686-9	2011	We propose that Lys-537(mBMAL1) acetylation enhances mCRY1 binding by affecting electrostatic interactions predominantly with the mCRY1 tail.	Lysine	16-19	cryptochrome 1 (photolyase-like)	Mus musculus	130-135
21454526-8	2011	In addition, cells expressing PKCzeta kinase motif mutants (Lys-281, Thr-410, Thr-560) fail to exhibit full MOR-induced desensitization of CCR5 activity.	Lysine	60-63	protein kinase C zeta	Homo sapiens	30-37
31518422-4	2019	The expression of hippocampal glucocorticoid receptors (GR) and histone deacetylase 2 (HDAC2) increased, whereas histone H3 lysine 14 acetylation (H3K14ac) of brain-derived neurotrophic factor (BDNF) exon IV (BDNF IV) and expression of BDNF decreased.	Lysine	124-130	brain-derived neurotrophic factor	Rattus norvegicus	159-192
31358728-5	2019	Importantly, lysine 152 (K152) within the Src homology 2 (SH2) domain of c-Src is involved in RACK1 binding.	Lysine	13-19	receptor for activated C kinase 1	Homo sapiens	94-99
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	38-44	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	69-73
21402181-6	2011	In contrast, microcapsules containing poly-L-lysine (PLL) induced elevated levels of sTCC, Bb, C3a and C5a, surface active C3 convertase and leukocyte adhesion.	Lysine	38-51	complement C3	Homo sapiens	95-98
20160011-3	2010	Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the ubiquitination and degradation of chromatin-associated RelA.	Lysine	98-105	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	69-73
20160011-6	2010	The acetylation of lysine 310 of RelA interferes with its interaction with Set9.	Lysine	19-25	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	75-79
31142615-4	2019	We provide evidence that the lysine residues at positions 6 and 8 of ERGIC3 are the major sites of MARCH2-mediated ubiquitination.	Lysine	29-35	ERGIC and golgi 3	Homo sapiens	69-75
20160011-7	2010	Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positive charge of lysine 310 is critical for the binding of RelA to a negatively charged "exosite" within the SET domain of Set9.	Lysine	105-111	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	50-54
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	ring finger protein 43	Homo sapiens	79-84
21463657-5	2011	Overexpression of TRIM29 promoted degradation and changed localization of Tip60 and reduced acetylation of p53 at lysine 120 by Tip60, resulting in enhancement of cell growth and transforming activity.	Lysine	114-120	lysine acetyltransferase 5	Homo sapiens	128-133
31286874-8	2019	Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells.	Lysine	123-129	ring finger protein 43	Homo sapiens	251-256
20160011-7	2010	Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positive charge of lysine 310 is critical for the binding of RelA to a negatively charged "exosite" within the SET domain of Set9.	Lysine	105-111	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	211-215
31270335-6	2019	Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation.	Lysine	103-109	lysine demethylase 4C	Homo sapiens	66-71
20433758-1	2010	BACKGROUND: MLL2, an epigenetic regulator in mammalian cells, mediates histone 3 lysine 4 tri-methylation (H3K4me3) through the formation of a multiprotein complex.	Lysine	81-87	lysine methyltransferase 2D	Homo sapiens	12-16
31270335-6	2019	Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation.	Lysine	103-109	cyclin E1	Homo sapiens	140-149
31270335-6	2019	Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation.	Lysine	103-109	cyclin E1	Homo sapiens	160-169
30714168-5	2019	FBXO16 interacts physically with the C-terminal domain of beta-catenin and promotes its lysine 48-linked polyubiquitination.	Lysine	88-94	F-box protein 16	Homo sapiens	0-6
20934317-7	2011	Chromatin immunoprecipitation (ChIP) assay demonstrated that the altered p16 mRNA level and transcription rate in LP offspring resulted from histone code changes, including the reduced acetylation of histone H4 and the dimethylation of histone H3 at lysine 4 residues within the p16 promoter region.	Lysine	250-256	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	73-76
21310711-2	2011	One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which requires histone methyltranferase complexes (HMT) containing the trithorax-group (trxG) protein ASH2.	Lysine	36-42	trithorax	Drosophila melanogaster	142-157
21310711-2	2011	One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which requires histone methyltranferase complexes (HMT) containing the trithorax-group (trxG) protein ASH2.	Lysine	36-42	trithorax	Drosophila melanogaster	159-163
21310711-2	2011	One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which requires histone methyltranferase complexes (HMT) containing the trithorax-group (trxG) protein ASH2.	Lysine	36-42	absent, small, or homeotic discs 2	Drosophila melanogaster	173-177
20140018-3	2010	We describe here a new level of regulation on pRb, mediated through the targeted methylation of lysine residues, by the methyltransferase Set7/9.	Lysine	96-102	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	138-144
21510664-3	2011	The first enzyme to show such activity was LSD1, a flavin-containing enzyme that removes the methyl groups from lysines 4 and 9 of histone 3 with the generation of formaldehyde from the methyl group.	Lysine	112-119	lysine demethylase 1A	Homo sapiens	43-47
20348416-4	2010	We show that the molecular mechanism of TBR1 suppression is based on the interaction of AF9 with DOT1L, a protein that mediates transcriptional control through methylation of histone H3 lysine 79 (H3K79).	Lysine	186-192	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	Mus musculus	88-91
21185811-2	2011	Human antiquitin (ALDH7A1) is believed to play a role in detoxification, osmoregulation and more specifically, in lysine metabolism in which alpha-aminoadipic semialdehyde is identified as the specific, physiological substrate of the enzyme.	Lysine	114-120	aldehyde dehydrogenase 7 family member A1	Homo sapiens	18-25
31117394-3	2019	We previously reported that a chemical catalyst (DSH) conjugated with a nucleosome-binding ligand can activate an acyl-CoA and promote site-selective lysine acylation of histones in test tubes.	Lysine	150-156	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	49-52
20348416-4	2010	We show that the molecular mechanism of TBR1 suppression is based on the interaction of AF9 with DOT1L, a protein that mediates transcriptional control through methylation of histone H3 lysine 79 (H3K79).	Lysine	186-192	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	97-102
31071300-10	2019	In conclusion, we demonstrated that RORalpha could alleviate LPS-induced inflammation and organ injury both in vivo and in vitro by blocking NF-kappaB p65 nuclear translocation and restricting acetylation of NF-kappaB p65 at lysine 310 via the regulation of SIRT1 expression.	Lysine	225-231	RAR related orphan receptor A	Homo sapiens	36-44
20351251-5	2010	We further demonstrated that both the self-ubiquitination of Ring1B and its modification by E6-AP target the same lysines, suggesting that the fate of Ring1B is tightly regulated (e.g., activation vs. degradation) by the type of chains and the ligase that catalyzes their formation.	Lysine	114-121	ring finger protein 2	Mus musculus	61-67
31095386-1	2019	We have recently reported a series of Lys-covalent agents targeting the BIR3 domain of the X-linked inhibitor of apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead.	Lysine	38-41	X-linked inhibitor of apoptosis	Homo sapiens	91-130
31095386-1	2019	We have recently reported a series of Lys-covalent agents targeting the BIR3 domain of the X-linked inhibitor of apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead.	Lysine	38-41	X-linked inhibitor of apoptosis	Homo sapiens	132-136
21419134-0	2011	Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.	Lysine	70-76	M-phase phosphoprotein 8	Homo sapiens	24-28
21419134-2	2011	MPP8, via its chromodomain, binds histone H3 peptide tri- or di-methylated at lysine 9 (H3K9me3/H3K9me2) in submicromolar affinity.	Lysine	78-84	M-phase phosphoprotein 8	Homo sapiens	0-4
21419134-4	2011	MPP8 interacts with at least six histone H3 residues from glutamine 5 to serine 10, enabling its ability to distinguish lysine-9-containing peptide (QTARKS) from that of lysine 27 (KAARKS), both sharing the ARKS sequence.	Lysine	120-126	M-phase phosphoprotein 8	Homo sapiens	0-4
20351251-5	2010	We further demonstrated that both the self-ubiquitination of Ring1B and its modification by E6-AP target the same lysines, suggesting that the fate of Ring1B is tightly regulated (e.g., activation vs. degradation) by the type of chains and the ligase that catalyzes their formation.	Lysine	114-121	ring finger protein 2	Mus musculus	151-157
21419134-4	2011	MPP8 interacts with at least six histone H3 residues from glutamine 5 to serine 10, enabling its ability to distinguish lysine-9-containing peptide (QTARKS) from that of lysine 27 (KAARKS), both sharing the ARKS sequence.	Lysine	170-176	M-phase phosphoprotein 8	Homo sapiens	0-4
20086098-7	2010	The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro.	Lysine	82-88	H2B clustered histone 21	Homo sapiens	75-78
21565694-1	2011	The structure of the receptor for advanced glycation end products (RAGE) in complex with a peptide containing an N(e)-carboxy-ethyl-lysine (CEL) (Xue et al., 2011) shows how the modification of the lysine side chain is recognized without specific interaction with the peptide.	Lysine	132-138	advanced glycosylation end-product specific receptor	Homo sapiens	21-65
21565694-1	2011	The structure of the receptor for advanced glycation end products (RAGE) in complex with a peptide containing an N(e)-carboxy-ethyl-lysine (CEL) (Xue et al., 2011) shows how the modification of the lysine side chain is recognized without specific interaction with the peptide.	Lysine	132-138	advanced glycosylation end-product specific receptor	Homo sapiens	67-71
21466165-7	2011	All parkin mutants tested effectively suppress arrestin ubiquitination, suggesting that bound parkin shields arrestin lysines targeted by Mdm2.	Lysine	118-125	MDM2 proto-oncogene	Homo sapiens	138-142
30880183-5	2019	In this study, we developed a predictor named LFPred to identify lysine formylation sites using sequence features (including amino acid composition (AAC), binary profile features (BPF), and amino acid index (AAI)) combined K-nearest neighbor algorithm as classifier.	Lysine	65-71	glycine-N-acyltransferase	Homo sapiens	149-152
31040182-6	2019	We additionally identify a nearby DNA-binding domain in UBN1, located between the UBN1 HRD and middle domain, which binds DNA through electrostatic contacts involving several conserved lysine residues.	Lysine	185-191	ubinuclein 1	Homo sapiens	56-60
31040182-6	2019	We additionally identify a nearby DNA-binding domain in UBN1, located between the UBN1 HRD and middle domain, which binds DNA through electrostatic contacts involving several conserved lysine residues.	Lysine	185-191	ubinuclein 1	Homo sapiens	82-86
20160126-3	2010	Despite minimal ongoing transcription in the absence of GH, both IGF-I promoters appear to reside in open chromatin environments, at least as inferred from relatively high levels of acetylation of core histones H3 and H4 when compared with adjacent intergenic DNA and from enhanced trimethylation of histone H3 at lysine 4.	Lysine	314-320	insulin-like growth factor 1	Rattus norvegicus	65-70
21573132-1	2011	Tumor suppressor gene CYLD is a deubiquitinating enzyme which negatively regulates various signaling pathways by removing the lysine 63-linked polyubiquitin chains from several specific substrates.	Lysine	126-132	CYLD lysine 63 deubiquitinase	Homo sapiens	22-26
20160126-8	2010	The coordinated induction of both IGF-I promoters by GH is accompanied by hyperacetylation of histones H3 and H4 in promoter-associated chromatin, a decline in monomethylation at lysine 4 of histone H3, and recruitment of RNA Pol II to IGF-I promoter 2.	Lysine	179-185	insulin-like growth factor 1	Rattus norvegicus	34-39
20118233-3	2010	Here, we describe a novel lysine methylation site in p53 that is carried out by two homologous histone methyltransferases, G9a and Glp.	Lysine	26-32	euchromatic histone lysine methyltransferase 1	Homo sapiens	131-134
21306770-4	2011	TRAIL-loaded nanoparticles (NPs) were prepared by mixing PEGylated heparin (PEG-HE), poly-L-lysine (PLL), and TRAIL.	Lysine	85-98	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	0-5
20118233-4	2010	G9a and Glp specifically methylate p53 at Lys(373), resulting mainly in dimethylation.	Lysine	42-45	euchromatic histone lysine methyltransferase 1	Homo sapiens	8-11
21436261-9	2011	Consistently, MMP14-null adipose tissues display diminished protranscriptional histone mark H3K9ac while maintaining repressive histone mark tri-methylated histone H3 at lysine 9 (H3K9me3).	Lysine	170-176	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	14-19
31173582-0	2019	Cyclophilin B control of lysine post-translational modifications of skin type I collagen.	Lysine	25-31	peptidylprolyl isomerase B	Mus musculus	0-13
31173582-2	2019	Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys) hydroxylation of type I collagen impacting cross-linking chemistry.	Lysine	146-152	peptidylprolyl isomerase B	Mus musculus	38-51
20175993-6	2010	A lysine-deficient LIGHT mutant [mLIGHT-Lys(-)] was isolated by panning against lymphotoxin beta receptor (LTbetaR).	Lysine	2-8	lymphotoxin beta receptor	Homo sapiens	80-105
31173582-2	2019	Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys) hydroxylation of type I collagen impacting cross-linking chemistry.	Lysine	146-152	peptidylprolyl isomerase B	Mus musculus	53-57
31173582-2	2019	Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys) hydroxylation of type I collagen impacting cross-linking chemistry.	Lysine	154-157	peptidylprolyl isomerase B	Mus musculus	38-51
31173582-2	2019	Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys) hydroxylation of type I collagen impacting cross-linking chemistry.	Lysine	154-157	peptidylprolyl isomerase B	Mus musculus	53-57
31173582-4	2019	Here, we report that, in CypB null (KO) mouse skin, two unusual collagen cross-links lacking Lys hydroxylation are formed while neither was detected in wild type (WT) or heterozygous (Het) mice.	Lysine	93-96	peptidylprolyl isomerase B	Mus musculus	25-29
21296085-8	2011	A novel second site, dependent on the C-terminus of CDC34, comprises a lysine-rich surface (K6, K11, K29, and K33) on the opposite face of Ub.	Lysine	71-77	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	52-57
20175993-6	2010	A lysine-deficient LIGHT mutant [mLIGHT-Lys(-)] was isolated by panning against lymphotoxin beta receptor (LTbetaR).	Lysine	2-8	lymphotoxin beta receptor	Homo sapiens	107-114
21483786-4	2011	In addition, the histone H3 lysine 27-specific demethylase JMJD3 induces ARF expression, thereby stabilizing p53 in mouse embryonic fibroblasts.	Lysine	28-34	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	59-64
30514804-1	2019	Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3.	Lysine	124-130	lysine demethylase 1A	Homo sapiens	0-29
20175993-6	2010	A lysine-deficient LIGHT mutant [mLIGHT-Lys(-)] was isolated by panning against lymphotoxin beta receptor (LTbetaR).	Lysine	40-43	lymphotoxin beta receptor	Homo sapiens	80-105
20194889-11	2010	Mutation of lysine 532 of HIF-1alpha in B16F10-mARD1A(225) cells prevented HIF-1alpha degradation and inhibited the antimetastatic effect of mARD1A(225) (P &lt; .001).	Lysine	12-18	hypoxia inducible factor 1, alpha subunit	Mus musculus	26-36
21245135-4	2011	During this initial process, SIRT1 deacetylated RelA/p65 lysine 310 and nucleosomal histone H4 lysine 16 to promote termination of NFkappaB-dependent transcription.	Lysine	57-63	sirtuin 1	Homo sapiens	29-34
20227666-4	2010	Set7/9-KMT7 associates with the HIV promoter in vivo and monomethylates lysine 51, a highly conserved residue located in the RNA-binding domain of Tat.	Lysine	72-78	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
30710318-2	2019	In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	45-48
30710318-2	2019	In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	50-55
20227666-4	2010	Set7/9-KMT7 associates with the HIV promoter in vivo and monomethylates lysine 51, a highly conserved residue located in the RNA-binding domain of Tat.	Lysine	72-78	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	7-11
30710318-2	2019	In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice.	Lysine	81-87	euchromatic histone lysine methyltransferase 2	Homo sapiens	57-62
21325892-9	2011	Hypoxia prevents IkappaBalpha de-sumoylation of Sumo-2/3 chains on critical lysine residues, normally required for K-48 linked polyubiquitination.	Lysine	76-82	small ubiquitin like modifier 2	Homo sapiens	48-56
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	adrenomedullin	Homo sapiens	150-153
20160506-7	2010	Tip60"s chromodomain then interacts with histone H3 trimethylated on lysine 9, activating Tip60"s acetyltransferase activity and stimulating the subsequent acetylation and activation of ATM"s kinase activity.	Lysine	69-75	ATM serine/threonine kinase	Homo sapiens	186-189
31150417-9	2019	In addition, we showed (1) a lysine residue in the Antagonist 2-4 is important for enhancing the antagonistic activity, (2) an analog consisted of an ADM sequence motif and a 12-amino-acid binding domain of CGRP exhibits potent CLR/RAMP1-inhibitory activity, and (3) a chimeric analog consisted of a somatostatin analog and an ADM antagonist exhibits dual activities on somatostatin and CLR/RAMP receptors.	Lysine	29-35	adrenomedullin	Homo sapiens	327-330
31118464-15	2019	LASER knock-down enhance LSD1 targeting to genomic loci, resulting in decreased histone H3 lysine 4 mono-methylation at the promoter regions of HNF-1alpha gene.	Lysine	91-97	lysine demethylase 1A	Homo sapiens	25-29
21634123-6	2011	Lysine-rich histone H1 facilitates the binding of the HMGB1 with DNA by screening the negatively charged groups of the sugar-phosphate backbone of DNA and dicarboxylic amino-acid residues in the C-terminal domain of the HMGB1 protein.	Lysine	0-6	H1.0 linker histone	Homo sapiens	12-22
21135101-5	2011	One in vitro generated LT mutant (LTK4R), in which the lysine at position 4 of the A subunit was replaced by arginine, showed most of the LT4 features with an ~10-fold reduction of the cytotonic effects, ADP-ribosylation activity, and accumulation of intracellular cAMP in Y1 cells.	Lysine	55-61	Leucine transport, high	Homo sapiens	23-25
20077120-8	2010	In XS52 cells, which express TLR2, TLR3, TLR4, and TLR7, but not TLR9, expression of claudin-7 protein was also increased after treatment with ligands of TLR2, TLR4 or TLR7/8, Pam3Cys-Ser-(Lys)4, LPS, or CL097.	Lysine	189-192	claudin 7	Mus musculus	85-94
21273081-3	2011	Each bind selectively to TTR and then chemoselectively react to form an amide bond with the Lys-15 residue of TTR, creating a fluorescent conjugate.	Lysine	92-95	transthyretin	Homo sapiens	25-28
21273081-3	2011	Each bind selectively to TTR and then chemoselectively react to form an amide bond with the Lys-15 residue of TTR, creating a fluorescent conjugate.	Lysine	92-95	transthyretin	Homo sapiens	110-113
20067792-2	2010	The PHF8 active site is highly conserved with those of the FBXL10/11demethylases, which are also selective for the di-/mono-methylated lysine states, but differs from that of the JMJD2 demethylases which are selective for tri-/di-methylated states.	Lysine	135-141	lysine demethylase 2B	Homo sapiens	59-65
21347367-4	2011	Analyzing the three dynamic trajectories (Aurora A-ATP, Aurora A-ADP, and Aurora A-ADP-TPX2) at the residue level, for the first time we find two TPX2-dependent switches, i.e., switch-1 (Lys-143) and switch-2 (Arg-180), which are tightly associated with Aurora A activation.	Lysine	187-190	TPX2 microtubule nucleation factor	Homo sapiens	87-91
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	Lysine	93-96	CART prepropeptide	Rattus norvegicus	131-176
30664848-8	2019	As a corollary, rMTBI also caused persistent decrease in the levels of acetylated histone H3-Lys 9 (H3-K9ac) in promoter region of cocaine- and amphetamine-regulated transcript (CART) gene with concurrent decline in CART mRNA and peptide (CARTp) levels.	Lysine	93-96	CART prepropeptide	Rattus norvegicus	178-182
21347367-4	2011	Analyzing the three dynamic trajectories (Aurora A-ATP, Aurora A-ADP, and Aurora A-ADP-TPX2) at the residue level, for the first time we find two TPX2-dependent switches, i.e., switch-1 (Lys-143) and switch-2 (Arg-180), which are tightly associated with Aurora A activation.	Lysine	187-190	TPX2 microtubule nucleation factor	Homo sapiens	146-150
20018852-2	2010	MOF is the catalytic subunit of the male-specific lethal (MSL) HAT complex, which plays a key role in dosage compensation in the fly and is responsible for a large fraction of histone H4 lysine 16 (H4K16) acetylation in vivo.	Lysine	187-193	males absent on the first	Drosophila melanogaster	0-3
21157427-3	2011	In this study, we provide the first evidence that the acetyltransferase Tip60 acetylates SRSF2 on its lysine 52 residue inside the RNA recognition motif, and promotes its proteasomal degradation.	Lysine	102-108	lysine acetyltransferase 5	Homo sapiens	72-77
30946839-0	2019	Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16.	Lysine	132-138	KRAS proto-oncogene, GTPase	Homo sapiens	14-18
21269365-8	2011	The mRNA expression of lysine alpha-ketoglutarate reductase (LKR), which is the enzyme involved in lysine (Lys) degradation and Glu production, was significantly increased (P &lt; 0.001) in the HCP group.	Lysine	23-29	L-2-hydroxyglutarate dehydrogenase	Homo sapiens	30-59
31123462-13	2019	Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.	Lysine	85-91	TNF superfamily member 11	Homo sapiens	192-197
21269365-8	2011	The mRNA expression of lysine alpha-ketoglutarate reductase (LKR), which is the enzyme involved in lysine (Lys) degradation and Glu production, was significantly increased (P &lt; 0.001) in the HCP group.	Lysine	107-110	L-2-hydroxyglutarate dehydrogenase	Homo sapiens	30-59
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	interleukin 1 alpha	Homo sapiens	107-111
20074553-4	2010	In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway.	Lysine	58-64	interleukin 1 alpha	Homo sapiens	129-133
20951760-6	2011	Following a search for potential peptidases we selected the Lys-endoproteinase, which cleaves the ECP polypeptide at the carboxyl side of its unique Lys residue, releasing the N-terminal fragment (0-38).	Lysine	60-63	ribonuclease A family member 3	Homo sapiens	98-101
30698750-3	2019	Here, we show that SDE2 cleavage after its ubiquitin-like domain generates Lys-SDE2Ct, the C-terminal SDE2 fragment bearing an N-terminal Lys residue.	Lysine	75-78	SDE2 telomere maintenance homolog	Homo sapiens	19-23
30698750-3	2019	Here, we show that SDE2 cleavage after its ubiquitin-like domain generates Lys-SDE2Ct, the C-terminal SDE2 fragment bearing an N-terminal Lys residue.	Lysine	75-78	SDE2 telomere maintenance homolog	Homo sapiens	79-83
20181089-4	2010	RESULTS: Our previous studies indicate that H3 lysine 4 trimethylation at cytokine-inducible MHC-II and CIITA promoters is dependent on proteolytic-independent functions of 19S ATPases.	Lysine	47-53	class II major histocompatibility complex transactivator	Homo sapiens	104-109
30698750-3	2019	Here, we show that SDE2 cleavage after its ubiquitin-like domain generates Lys-SDE2Ct, the C-terminal SDE2 fragment bearing an N-terminal Lys residue.	Lysine	138-141	SDE2 telomere maintenance homolog	Homo sapiens	19-23
30698750-3	2019	Here, we show that SDE2 cleavage after its ubiquitin-like domain generates Lys-SDE2Ct, the C-terminal SDE2 fragment bearing an N-terminal Lys residue.	Lysine	138-141	SDE2 telomere maintenance homolog	Homo sapiens	79-83
30951900-0	2019	Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1alpha-dependent pathway.	Lysine	14-20	lysine demethylase 1A	Homo sapiens	42-46
21115810-3	2011	We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes.	Lysine	136-139	lysine demethylase 1A	Homo sapiens	118-122
21345146-3	2011	CYLD is a deubiquitination enzyme that can cleave the lysine 63-linked polyubiquitin chains from target proteins and regulate cell survival or cell proliferation.	Lysine	54-60	CYLD lysine 63 deubiquitinase	Homo sapiens	0-4
20181089-5	2010	In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters.	Lysine	382-388	lysine methyltransferase 2A	Homo sapiens	85-88
20181089-5	2010	In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters.	Lysine	382-388	class II major histocompatibility complex transactivator	Homo sapiens	185-190
20181089-5	2010	In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters.	Lysine	382-388	lysine methyltransferase 2A	Homo sapiens	238-241
21299644-6	2011	Additionally, Lys-37 and Lys-62 were identified as being involved in ArsD function by site-directed mutagenesis and chemical modification.	Lysine	14-17	arylsulfatase D	Homo sapiens	69-73
20181089-5	2010	In this report, we show that multiple common subunits of the mixed lineage leukemia (MLL)/complex of proteins associated with Set I (COMPASS) complexes bind to the inducible MHC-II and CIITA promoters; that overexpressing a single common MLL/COMPASS subunit significantly enhances promoter activity and MHC-II HLA-DRA expression; and that these common subunits are important for H3 lysine 4 trimethylation at MHC-II and CIITA promoters.	Lysine	382-388	class II major histocompatibility complex transactivator	Homo sapiens	420-425
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 8	Homo sapiens	19-21
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	small ubiquitin like modifier 2	Homo sapiens	57-63
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	76-79	keratin 8	Homo sapiens	93-95
31043584-6	2019	Mutations of these three lysine sites in XRCC1 abrogated the interaction with beta-TrCP and prolonged the half-life of XRCC1 protein.	Lysine	25-31	X-ray repair cross complementing 1	Homo sapiens	41-46
31043584-6	2019	Mutations of these three lysine sites in XRCC1 abrogated the interaction with beta-TrCP and prolonged the half-life of XRCC1 protein.	Lysine	25-31	X-ray repair cross complementing 1	Homo sapiens	119-124
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 8	Homo sapiens	19-21
20152160-5	2010	Indeed, biochemical assays support a model in which the self-assembled UbcH5b~Ub can serve as a bridge for the gap between the lysine residue of the substrate and the catalytic cysteine of E2.	Lysine	127-133	ubiquitin conjugating enzyme E2 D2	Homo sapiens	71-77
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	small ubiquitin like modifier 2	Homo sapiens	57-63
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	keratin 8	Homo sapiens	19-21
21062750-5	2011	Upon transfection, K8, K18, and K19 are modified by poly-SUMO-2/3 chains on Lys-285/Lys-364 (K8), Lys-207/Lys-372 (K18), and Lys-208 (K19).	Lysine	84-87	small ubiquitin like modifier 2	Homo sapiens	57-63
21149657-0	2011	Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma.	Lysine	218-224	CD8a molecule	Homo sapiens	13-16
31061526-3	2019	C21orf127 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12) in vitro and in vivo.	Lysine	93-99	N-6 adenine-specific DNA methyltransferase 1	Homo sapiens	0-9
31061526-3	2019	C21orf127 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12) in vitro and in vivo.	Lysine	93-99	tRNA methyltransferase activator subunit 11-2	Homo sapiens	52-59
31061526-4	2019	We characterized H4K12 recognition by solving the crystal structure of human C21orf127-TRMT112, hereafter termed "lysine methyltransferase 9" (KMT9), in complex with S-adenosyl-homocysteine and H4K12me1 peptide.	Lysine	114-120	N-6 adenine-specific DNA methyltransferase 1	Homo sapiens	77-86
31061526-4	2019	We characterized H4K12 recognition by solving the crystal structure of human C21orf127-TRMT112, hereafter termed "lysine methyltransferase 9" (KMT9), in complex with S-adenosyl-homocysteine and H4K12me1 peptide.	Lysine	114-120	tRNA methyltransferase activator subunit 11-2	Homo sapiens	87-94
30718920-1	2019	Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.	Lysine	0-6	euchromatic histone lysine methyltransferase 2	Homo sapiens	126-129
19875981-3	2010	Sas2 acetylates histone H4 lysine 16 (H4K16), and telomere shortening in tlc1 mutants was accompanied by a selective and Sas2-dependent increase in subtelomeric H4K16 acetylation.	Lysine	27-33	TLC1	Saccharomyces cerevisiae S288C	73-77
30718920-1	2019	Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.	Lysine	0-6	euchromatic histone lysine methyltransferase 2	Homo sapiens	130-135
20875748-0	2011	Unfolding diminishes fluorescence resonance energy transfer (FRET) of lysine modified beta-lactoglobulin: Relevance towards anti-HIV binding.	Lysine	70-76	beta-lactoglobulin	Bos taurus	86-104
20875748-4	2011	In this article, interactions between lysine modified bovine beta-lactoglobulin (beta-lg) and a hydrophobic fluorescence probe, 1-anilinonapthalene-8-sulfonate (ANS), have been studied with the help of fluorescence resonance energy transfer (FRET) process.	Lysine	38-44	beta-lactoglobulin	Bos taurus	61-79
20875748-4	2011	In this article, interactions between lysine modified bovine beta-lactoglobulin (beta-lg) and a hydrophobic fluorescence probe, 1-anilinonapthalene-8-sulfonate (ANS), have been studied with the help of fluorescence resonance energy transfer (FRET) process.	Lysine	38-44	beta-lactoglobulin	Bos taurus	81-88
20875748-5	2011	Lysine residues of beta-lg were modified by acetylation and succinylation.	Lysine	0-6	beta-lactoglobulin	Bos taurus	19-26
21047797-2	2011	They are evolutionarily related to the Drosophila HP1 (dHP1) and Pc (dPc) proteins that are key components of chromatin-associated complexes capable of recognizing repressive marks such as trimethylated Lys-9 and Lys-27, respectively, on histone H3.	Lysine	213-216	Heterochromatin Protein 1c	Drosophila melanogaster	55-59
30846414-2	2019	The oncogenic role of lysine-specific demethylase1 (LSD1/KDM1 A) has been well recognized in PC.	Lysine	22-28	lysine demethylase 1A	Homo sapiens	52-56
30846414-2	2019	The oncogenic role of lysine-specific demethylase1 (LSD1/KDM1 A) has been well recognized in PC.	Lysine	22-28	lysine demethylase 1A	Homo sapiens	57-63
19968269-2	2010	Polyacridine peptides of the general formula (Acr-X)(n)-Cys were prepared by solid-phase peptide synthesis, where Acr is Lys modified on its epsilon-amine with acridine, X is Arg, Leu, or Lys and n is 2, 3, or 4 repeats.	Lysine	121-124	acrosin	Homo sapiens	114-117
21692557-5	2011	Interestingly, Bm-UB and Ha-UB share the same seven lysines except for an additional Lys54 in Bm-UB.	Lysine	52-59	Ubiquitin	Bombyx mori nucleopolyhedrovirus	28-30
19968269-2	2010	Polyacridine peptides of the general formula (Acr-X)(n)-Cys were prepared by solid-phase peptide synthesis, where Acr is Lys modified on its epsilon-amine with acridine, X is Arg, Leu, or Lys and n is 2, 3, or 4 repeats.	Lysine	188-191	acrosin	Homo sapiens	114-117
21151116-0	2011	A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.	Lysine	61-67	DNA methyltransferase 1	Homo sapiens	96-101
20593461-2	2010	The Lys(Thz) residue was incorporated into the murine chemokine RANTES to demonstrate its compatibility with Boc/Bzl solid phase peptide synthesis, native chemical ligation, and disulfide bond formation.	Lysine	4-7	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	109-112
21829450-0	2011	The C-terminus of histone H2B is involved in chromatin compaction specifically at telomeres, independently of its monoubiquitylation at lysine 123.	Lysine	136-142	histone H2B	Saccharomyces cerevisiae S288C	18-29
31024026-3	2019	Polycomb repressive complex 2 (PRC2), which contains core subunits (EZH2, EED, and SUZ12), regulates gene activity by trimethylation of histone 3 lysine 27.	Lysine	146-152	embryonic ectoderm development	Homo sapiens	74-77
31004086-4	2019	Our results support a model in which the effect of GFI1"s regulation of methylation at the c-terminus of p53 is ultimately mediated through control of acetylation at lysine 117 of p53.	Lysine	166-172	growth factor independent 1 transcription repressor	Mus musculus	51-55
20157260-7	2010	This was accompanied by significant changes in brain fatty acid composition in AbetaPP/PS1 mice that led to a lower membrane peroxidizability index and to reduced protein oxidative damage, as revealed by reduced percentages of the oxidative stress markers: glutamic semialdehyde, aminoadipic semialdehyde, Nepsilon-carboxymethyl-lysine, Nepsilon-carboxyethyl-lysine, and Nepsilon-malondialdehyde-lysine.	Lysine	329-335	presenilin 1	Mus musculus	87-90
30969965-2	2019	In this study, we exploited yeast one-hybrid (Y1H) to screen for the upstream regulators of NONYELLOWING1 (NYE1), and identified RELATIVE OF EARLY FLOWERING6 (REF6), a histone H3 lysine 27 tri-methylation (H3K27me3) demethylase, as a putative binding protein of NYE1 promoter.	Lysine	179-185	relative of early flowering 6	Arabidopsis thaliana	159-163
21179169-5	2010	Here we show in human cell lines that ZRF1 (zuotin-related factor 1) is specifically recruited to histone H2A when it is ubiquitinated at Lys 119 by means of a novel ubiquitin-interacting domain that is located in the evolutionarily conserved zuotin domain.	Lysine	138-141	DnaJ heat shock protein family (Hsp40) member C2	Homo sapiens	38-42
21179169-5	2010	Here we show in human cell lines that ZRF1 (zuotin-related factor 1) is specifically recruited to histone H2A when it is ubiquitinated at Lys 119 by means of a novel ubiquitin-interacting domain that is located in the evolutionarily conserved zuotin domain.	Lysine	138-141	DnaJ heat shock protein family (Hsp40) member C2	Homo sapiens	44-67
20952395-10	2010	In addition, each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetylated when this agent is removed.	Lysine	34-40	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	60-64
20023648-6	2010	Mechanistically, we provide evidence that HERC2 facilitates assembly of the ubiquitin-conjugating enzyme Ubc13 with RNF8, thereby promoting DNA damage-induced formation of Lys 63-linked ubiquitin chains.	Lysine	172-175	ubiquitin conjugating enzyme E2 N	Homo sapiens	105-110
21156283-3	2010	Inhibition of JAK2 and JMJD2C cooperated in killing these lymphomas by decreasing tyrosine 41 phosphorylation and increasing lysine 9 trimethylation of histone H3, promoting heterochromatin formation.	Lysine	125-131	lysine demethylase 4C	Homo sapiens	23-29
31024250-3	2019	EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and trimethylation of lysine 27 of histone 3 (H3K27Me3), the chromatin mark associated with gene silencing.	Lysine	127-133	embryonic ectoderm development	Homo sapiens	6-9
20023648-6	2010	Mechanistically, we provide evidence that HERC2 facilitates assembly of the ubiquitin-conjugating enzyme Ubc13 with RNF8, thereby promoting DNA damage-induced formation of Lys 63-linked ubiquitin chains.	Lysine	172-175	ring finger protein 8	Homo sapiens	116-120
30710424-9	2019	The marked reduction in SIRT1 expression by combination of metformin and tenovin-6 increased acetylation of p53 at lysine 382 and enhanced p53 stability in LKB1-deficient A549 cells.	Lysine	115-121	sirtuin 1	Homo sapiens	24-29
21109197-3	2010	HMGCS2 is the rate-limiting step in beta-hydroxybutyrate synthesis and is hyperacetylated at lysines 310, 447, and 473 in the absence of SIRT3.	Lysine	93-100	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	0-6
21109197-6	2010	Deacetylation of HMGCS2 lysines 310, 447, and 473 by incubation with wild-type SIRT3 or by mutation to arginine enhances its enzymatic activity.	Lysine	24-31	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	17-23
19877718-7	2009	Replacement of an Ala in the N-terminal half of the neuromodulin sequence with the Gln in PEP19 accounts for approximately half of the Ca(2+)-independent difference in the stabilities of the two reporter complexes, with the Ca(2+)-independent effect of the Lys replacement accounting for most of the remainder.	Lysine	257-260	growth associated protein 43	Homo sapiens	52-64
20003410-4	2009	RESULTS: We report that H2A.Z-1 and H2A.Z-2 are expressed across a wide range of human tissues, they are both acetylated at lysine residues within the N-terminal region and they exhibit similar, but nonidentical, distributions within chromatin.	Lysine	124-130	H2A.Z variant histone 1	Homo sapiens	24-31
21074459-4	2010	TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination.	Lysine	49-55	tripartite motif containing 56	Homo sapiens	0-6
30628173-5	2019	Notably, FOXM1 expression was epigenetically regulated by dimethylation on H3 lysine 79 (H3K79me2), a modification present in both tumor cells and BMDCs.	Lysine	78-84	forkhead box M1	Mus musculus	9-14
20003410-5	2009	Our results suggest that H2A.Z-2 preferentially associates with H3 trimethylated at lysine 4 compared to H2A.Z-1.	Lysine	84-90	H2A.Z variant histone 1	Homo sapiens	105-112
19954517-5	2009	We have previously shown that acetylation of specific histone lysine residues on the photosynthetic phosphoenolpyruvate carboxylase (Pepc) promoter in maize is controlled by light and is independent of other stimuli or gene activity.	Lysine	62-68	MLO-like protein 4	Zea mays	100-131
30560355-6	2019	Further, SAA could interact with the lysine residue 633 (K633) of GRP78, which inhibited GRP78 secretion.	Lysine	37-43	serum amyloid A1 cluster	Homo sapiens	9-12
30935141-6	2019	Chromatin immunoprecipitation analysis indicated that NCL1 induced histone H3 lysine 9 dimethylation accumulation at promoters of P21.	Lysine	78-84	calpain 3	Homo sapiens	54-58
20829358-6	2010	Additionally, a BAF57 mutant, which contains no lysine residues, was found to retain its ability to be stabilized by interaction with BAF155, suggesting that in addition to the ubiquitin-dependent mechanism of BAF57 degradation, there exists a ubiquitin-independent mechanism that may involve the direct interaction of BAF57 with the proteasome.	Lysine	48-54	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	134-140
20623672-4	2010	In the work described here, LBL-produced col/hep coating growth is initialized by deposition of a layer of poly-L-lysine on a titanium surface, which is negatively charged after treatment with NaOH, followed by formation of a multilayer film formed by alternating deposition of negatively charged heparin and positively charged collagen using electrostatic interaction.	Lysine	107-120	DNL-type zinc finger	Homo sapiens	45-48
19954517-5	2009	We have previously shown that acetylation of specific histone lysine residues on the photosynthetic phosphoenolpyruvate carboxylase (Pepc) promoter in maize is controlled by light and is independent of other stimuli or gene activity.	Lysine	62-68	MLO-like protein 4	Zea mays	133-137
19955365-0	2009	Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.	Lysine	46-52	caspase 7	Homo sapiens	111-120
20937132-9	2010	In silico analysis showed that VWT-STAT1-STAT2 complex occurs through the V protein Trp-motif (W174, W178, W189) and Glu95 residue close to the Arg409 and Lys415 of the nuclear localization signal (NLS) of STAT2, leaving exposed STAT1 Lys residues (K85, K87, K296, K413, K525, K679, K685), which are susceptible to proteasome degradation.	Lysine	155-158	signal transducer and activator of transcription 1	Homo sapiens	35-40
20937132-9	2010	In silico analysis showed that VWT-STAT1-STAT2 complex occurs through the V protein Trp-motif (W174, W178, W189) and Glu95 residue close to the Arg409 and Lys415 of the nuclear localization signal (NLS) of STAT2, leaving exposed STAT1 Lys residues (K85, K87, K296, K413, K525, K679, K685), which are susceptible to proteasome degradation.	Lysine	155-158	signal transducer and activator of transcription 2	Homo sapiens	41-46
19759058-3	2009	Further analysis of these cleavage sites and substitution mutation experiments revealed that for certain cleavage sites a lysine at the P5 position contributes to the discrimination between caspase-7 and -3 specificity.	Lysine	122-128	caspase 7	Mus musculus	190-206
20937132-9	2010	In silico analysis showed that VWT-STAT1-STAT2 complex occurs through the V protein Trp-motif (W174, W178, W189) and Glu95 residue close to the Arg409 and Lys415 of the nuclear localization signal (NLS) of STAT2, leaving exposed STAT1 Lys residues (K85, K87, K296, K413, K525, K679, K685), which are susceptible to proteasome degradation.	Lysine	155-158	signal transducer and activator of transcription 2	Homo sapiens	206-211
20937132-9	2010	In silico analysis showed that VWT-STAT1-STAT2 complex occurs through the V protein Trp-motif (W174, W178, W189) and Glu95 residue close to the Arg409 and Lys415 of the nuclear localization signal (NLS) of STAT2, leaving exposed STAT1 Lys residues (K85, K87, K296, K413, K525, K679, K685), which are susceptible to proteasome degradation.	Lysine	155-158	signal transducer and activator of transcription 1	Homo sapiens	229-234
20682771-1	2010	The extracellular protease plasmin cleaves mouse MCP1 (monocyte chemoattractant protein 1) at lysine 104, releasing a 50-amino acid C-terminal domain.	Lysine	94-100	chemokine (C-C motif) ligand 2	Mus musculus	49-53
20682771-1	2010	The extracellular protease plasmin cleaves mouse MCP1 (monocyte chemoattractant protein 1) at lysine 104, releasing a 50-amino acid C-terminal domain.	Lysine	94-100	chemokine (C-C motif) ligand 2	Mus musculus	55-89
30934546-0	2019	Effect of Poly-l-Lysine Polycation on the Glucose Oxidase/Ferricyanide Composite-Based Second-Generation Blood Glucose Sensors.	Lysine	10-23	hydroxyacid oxidase 1	Homo sapiens	42-57
30909651-7	2019	We further investigated the mechanism of action of YM155 by looking at the change of lysine modifications of the histone tails that were within 250 base pairs of the Birc5 promoter.	Lysine	85-91	baculoviral IAP repeat containing 5	Homo sapiens	166-171
19676115-7	2009	Our model, which is in the agreement with the NMR data, suggests that the binding interface of B2GPI for the lipoprotein receptors is centered at three lysine residues of B2GPI-DV, Lys 308, Lys 282, and Lys317.	Lysine	152-158	apolipoprotein H	Homo sapiens	95-100
30893611-5	2019	18S NRD requires Mag2-mediated monoubiquitination followed by Hel2- and Rsp5-mediated K63-linked polyubiquitination of uS3 at the 212th lysine residue.	Lysine	136-142	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	72-76
20685652-4	2010	Two sumoylation sites were identified on the S100A4 molecule, Lys(22) and Lys(96).	Lysine	62-65	S100 calcium binding protein A4	Homo sapiens	45-51
20685652-5	2010	Mutation of these lysine residues abolished the ability of S100A4 to be sumoylated and to translocate into the nucleus.	Lysine	18-24	S100 calcium binding protein A4	Homo sapiens	59-65
20949080-8	2010	Microarray and chromatin immunoprecipitation analyses showed that LAZ2/SDG8 is required for LAZ5 expression and H3 lysine 36 trimethylation at LAZ5 chromatin to maintain a transcriptionally active state.	Lysine	115-121	Disease resistance protein (TIR-NBS-LRR class) family	Arabidopsis thaliana	143-147
19676115-7	2009	Our model, which is in the agreement with the NMR data, suggests that the binding interface of B2GPI for the lipoprotein receptors is centered at three lysine residues of B2GPI-DV, Lys 308, Lys 282, and Lys317.	Lysine	181-184	apolipoprotein H	Homo sapiens	95-100
30826357-9	2019	Among them, lysine-specific demethylase 5D (KDM5D) exhibited pronounced overexpression accompanied by a reduction in the protein levels of its substrate, the trimethylated lysine 4 of histone H3 (H3K4me3), in patients with CVD.	Lysine	12-18	lysine demethylase 5D	Homo sapiens	44-49
19676115-7	2009	Our model, which is in the agreement with the NMR data, suggests that the binding interface of B2GPI for the lipoprotein receptors is centered at three lysine residues of B2GPI-DV, Lys 308, Lys 282, and Lys317.	Lysine	190-193	apolipoprotein H	Homo sapiens	95-100
20373119-3	2010	The observation of the high lysine content of the endosperm of the opaque-2 (o2) maize mutant was a key factor in bringing about a new concept in the production of cereal seeds with a high nutritional value.	Lysine	28-34	regulatory protein opaque-2	Zea mays	67-75
19924293-8	2009	The basic arginine-lysine-lysine-arginine (RKKR) sequence, located 12-aa from the C-terminal end of Foxp3 was previously reported to be a nuclear localization signal (NLS) for several proteins, including for a GFP-Foxp3 hybrid.	Lysine	19-25	forkhead box P3	Mus musculus	100-105
20798608-3	2010	Recently, we found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediates Lys(63) (K63)- linked ubiquitination of Beclin 1 is crucial for TLR4-triggered autophagy in macrophages.	Lysine	99-102	beclin 1	Homo sapiens	139-147
20798608-5	2010	A lysine located in the Bcl-2 homology 3 (BH3) domain of Beclin 1 serves as a major site for K63-linked ubiquitination.	Lysine	2-8	beclin 1	Homo sapiens	57-65
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Lysine	25-32	zinc finger and BTB domain containing 7B	Homo sapiens	75-80
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Lysine	25-32	CD8a molecule	Homo sapiens	136-139
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Lysine	25-32	CD8a molecule	Homo sapiens	176-179
30759380-3	2019	Dot1L activity is part of a trans-histone crosstalk pathway, requiring prior histone H2B ubiquitylation of lysine 120 (H2BK120ub) for optimal activity.	Lysine	107-113	H2B clustered histone 12	Homo sapiens	119-123
30569092-1	2019	Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono- and di-methylated ninth lysine of histone 3 and belongs to the Jumonji domain-containing group of demethylases.	Lysine	20-26	lysine (K)-specific demethylase 3A L homeolog	Xenopus laevis	43-48
19924293-8	2009	The basic arginine-lysine-lysine-arginine (RKKR) sequence, located 12-aa from the C-terminal end of Foxp3 was previously reported to be a nuclear localization signal (NLS) for several proteins, including for a GFP-Foxp3 hybrid.	Lysine	19-25	forkhead box P3	Mus musculus	214-219
19763625-4	2009	In vitro, TSLP is significantly produced in HNECs after treatment with a toll-like receptor 2 (TLR2) ligand, Pam(3)Cys-Ser-(Lys)(4), and a mixture of interleukin-1beta and tumor necrosis factor-alpha.	Lysine	124-127	thymic stromal lymphopoietin	Homo sapiens	10-14
30530489-4	2019	Interestingly, CRISPR/Cas9-mediated KO of FAM173B in mammalian cells abrogated trimethylation of Lys-43 in ATP synthase c-subunit (ATPSc), a modification previously reported as ubiquitous among metazoans.	Lysine	97-100	ATP synthase membrane subunit c locus 2	Homo sapiens	107-129
30530489-4	2019	Interestingly, CRISPR/Cas9-mediated KO of FAM173B in mammalian cells abrogated trimethylation of Lys-43 in ATP synthase c-subunit (ATPSc), a modification previously reported as ubiquitous among metazoans.	Lysine	97-100	ATP synthase membrane subunit c locus 2	Homo sapiens	131-136
30530489-5	2019	ATPSc methylation was restored by complementing the KO cells with enzymatically active human FAM173B or with a putative FAM173B orthologue from the nematode Caenorhabditis elegans Interestingly, lack of Lys-43 methylation caused aberrant incorporation of ATPSc into the ATP synthase complex and resulted in decreased ATP-generating ability of the complex, as well as decreased mitochondrial respiration.	Lysine	203-206	ATP synthase membrane subunit c locus 2	Homo sapiens	0-5
20849068-2	2010	The peptides were first identified by comparing the substrate specificity profiles of the four KDAC isoforms KDAC2, KDAC3, KDAC8, and sirtuin 1 (SIRT1) on a 361-member hexapeptide array wherein the two C-terminal residues to the acetylated lysine were varied.	Lysine	240-246	sirtuin 1	Homo sapiens	134-143
20849068-2	2010	The peptides were first identified by comparing the substrate specificity profiles of the four KDAC isoforms KDAC2, KDAC3, KDAC8, and sirtuin 1 (SIRT1) on a 361-member hexapeptide array wherein the two C-terminal residues to the acetylated lysine were varied.	Lysine	240-246	sirtuin 1	Homo sapiens	145-150
20805500-5	2010	HFE was ubiquitinated on lysine-331 in unactivated BC-3 cells, conditions where K5 was not detectable, consistent with an endogenous E3 ubiquitin ligase controlling HFE expression.	Lysine	25-31	homeostatic iron regulator	Mus musculus	0-3
30881620-3	2019	Our previous SAR studies of compounds, showing affinity for NRP-1, led us to develop branched peptides with general formula Lys(hArg)-AA2-AA3-Arg.	Lysine	124-127	AA2	Homo sapiens	134-137
19883617-3	2009	Lysine 217 of FXR is the major acetylation site targeted by p300 and SIRT1.	Lysine	0-6	sirtuin 1	Mus musculus	69-74
30341248-4	2019	Western Blot and immunoprecipitation were used to detect BDNF and histone acetylation of histone H3 lysine 9 (H3K9) and histone H4 lysine 12 (H4K12) in the hippocampus.	Lysine	100-106	brain-derived neurotrophic factor	Rattus norvegicus	57-61
20840750-7	2010	Moreover, using oligonucleotide-based degenerate PCR, we discovered that mutation of Arg-501 and Lys-503 of mCRY2 within this C-terminal region totally abolishes interaction with PER2.	Lysine	97-100	period circadian regulator 2	Homo sapiens	179-183
19731963-6	2009	Especially, several lysine residues on the SAGA subunits Spt7p and Sgf73p were found to be acetylated.	Lysine	20-26	deubiquitination module subunit SGF73	Saccharomyces cerevisiae S288C	67-73
20816089-3	2010	Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.	Lysine	250-256	forkhead box O3	Mus musculus	46-52
19943104-5	2010	UHRF1 also recruited histone lysine methyltransferase G9a to the BRCA1 promoter and histone 3 lysine 4 (H3K4) was demethylated, and histone 3 lysine 9 (H3K9) was methylated.	Lysine	29-35	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	0-5
30651137-4	2019	RESULTS: First, we found two histone demethylases associated with histone H3 lysine 27 trimethylation (H3K27me3) demethylation, KDM6A, and KDM6B that were upregulated after cisplatin treatment.	Lysine	77-83	lysine demethylase 6B	Homo sapiens	139-144
30655546-3	2019	Here, we show that high maternal glucose induced MARCKS acetylation at lysine 165 by the acetyltransferase Tip60, which is a prerequisite for its phosphorylation, whereas Sirtuin 2 (SIRT2) deacetylated MARCKS.	Lysine	71-77	lysine acetyltransferase 5	Homo sapiens	107-112
19943104-5	2010	UHRF1 also recruited histone lysine methyltransferase G9a to the BRCA1 promoter and histone 3 lysine 4 (H3K4) was demethylated, and histone 3 lysine 9 (H3K9) was methylated.	Lysine	29-35	BRCA1 DNA repair associated	Homo sapiens	65-70
19740772-8	2009	Our data suggest that by acetylating H3 at lysine 9, dSAGA modifies Pol II accessibility to specific promoters differently.	Lysine	43-49	RNA polymerase II 215kD subunit	Drosophila melanogaster	68-74
19943104-5	2010	UHRF1 also recruited histone lysine methyltransferase G9a to the BRCA1 promoter and histone 3 lysine 4 (H3K4) was demethylated, and histone 3 lysine 9 (H3K9) was methylated.	Lysine	94-100	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	0-5
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	197-200	lysine acetyltransferase 5	Homo sapiens	20-25
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	197-200	lysine acetyltransferase 5	Homo sapiens	133-138
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	208-211	lysine acetyltransferase 5	Homo sapiens	20-25
30409912-6	2019	We demonstrate that TIP60 regulates the dynamic interactions between NDC80 and spindle microtubules during mitosis and observed that TIP60 acetylates HEC1 at two evolutionarily conserved residues, Lys-53 and Lys-59.	Lysine	208-211	lysine acetyltransferase 5	Homo sapiens	133-138
20652590-5	2010	Whereas Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).	Lysine	79-85	Wsc2p	Saccharomyces cerevisiae S288C	53-57
19706600-3	2009	Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation.	Lysine	98-104	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	67-71
20797634-5	2010	We have identified 103 SUMO-2 acceptor lysines in endogenous target proteins.	Lysine	39-46	small ubiquitin like modifier 2	Homo sapiens	23-29
19706600-3	2009	Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation.	Lysine	98-104	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	183-187
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Lysine	64-70	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	59-63
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Lysine	64-70	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	119-123
20525693-0	2010	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	Lysine	116-122	serum/glucocorticoid regulated kinase 1	Homo sapiens	0-47
29663427-8	2019	RESULTS: The serum SPD level was significantly lower (P &lt; .001) in AERD compared with ATA patients, and negatively correlated with fall in FEV1 (%) after lysine-aspirin bronchoprovocation test and/or the urinary LTE4 level.	Lysine	157-163	surfactant protein D	Homo sapiens	19-22
19710011-4	2009	Here we report that TP2 is acetylated in vivo as detected by anti-acetylated lysine antibody and mass spectrometric analysis.	Lysine	77-83	transition protein 2	Homo sapiens	20-23
20452361-3	2010	Here, we demonstrate that the third PHD domain of MLL (PHD3) binds histone H3 trimethylated at lysine 4 (H3K4me3) with high affinity and specificity and H3K4me2 with 8-fold lower affinity.	Lysine	95-101	egl-9 family hypoxia inducible factor 3	Homo sapiens	55-59
19710011-8	2009	Mass spectrometric analysis showed that p300 acetylates four lysine residues in the C-terminal domain of TP2.	Lysine	61-67	transition protein 2	Homo sapiens	105-108
30287244-3	2019	All members share a common catalytic mechanism, which involves a conserved catalytic triad, constituted by two histidines and a lysine (His15/His122/Lys38 in RNase6 corresponding to His12/His119/Lys41 in RNaseA).	Lysine	128-134	ribonuclease A family member k6	Homo sapiens	158-164
19779240-4	2009	In addition, the surface charge of FND influences its cellular uptake, as the uptake of poly-L-lysine-coated FNDs is better than that of oxidative-acid-purified FNDs at the same concentration in regular medium with or without serum.	Lysine	88-101	ALX homeobox 3	Homo sapiens	35-38
30466837-3	2019	The C1  atom of the AP site participates in Schiff base formation with a lysine side chain in PARP-1, and a covalent bond is formed upon reduction of the Schiff base.	Lysine	73-79	poly (ADP-ribose) polymerase family, member 1	Mus musculus	94-100
20472764-4	2010	The enzyme lysyl oxidase (LOX) is a copper-dependent extracellular enzyme that catalyzes lysine-derived cross-links in collagen and elastin.	Lysine	89-95	lysyl oxidase	Homo sapiens	11-24
20472764-4	2010	The enzyme lysyl oxidase (LOX) is a copper-dependent extracellular enzyme that catalyzes lysine-derived cross-links in collagen and elastin.	Lysine	89-95	lysyl oxidase	Homo sapiens	26-29
20472764-4	2010	The enzyme lysyl oxidase (LOX) is a copper-dependent extracellular enzyme that catalyzes lysine-derived cross-links in collagen and elastin.	Lysine	89-95	elastin	Homo sapiens	132-139
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	RUNX family transcription factor 3	Homo sapiens	12-17
20346413-7	2010	Lyso derivatives were also generated upon the cleavage by Lp-PLA2 of a model ox-PL chemically linked to a lysine-containing pentapeptide.	Lysine	106-112	phospholipase A2 group VII	Homo sapiens	58-65
30093630-3	2019	Here, we report a novel cisplatin-resistance mechanism involving SET Domain Containing 2 (SETD2), a histone H3 lysine 36 (H3K36) trimethyltransferase, and cAMP-responsive element-binding protein 1 (CREB1).	Lysine	111-117	cAMP responsive element binding protein 1	Homo sapiens	198-203
30171259-1	2019	NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL), and cells harboring this mutation can become the predominant clone in relapsing disease.	Lysine	72-78	nuclear receptor binding SET domain protein 2	Mus musculus	0-4
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	35-38	sirtuin 1	Homo sapiens	0-5
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	RUNX family transcription factor 3	Homo sapiens	63-68
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	43-46	sirtuin 1	Homo sapiens	0-5
30327428-4	2018	SIRT1 deacetylates XPA at residues Lys-63, Lys-67, and Lys-215 to promote interactions with ATR.	Lysine	43-46	sirtuin 1	Homo sapiens	0-5
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	RUNX family transcription factor 3	Homo sapiens	63-68
20571979-3	2010	Activation of mGluR2 has been associated with the antipsychotic-like behavioral effects of LY-404039, as indicated by experiments using mGluR2-/- and mGluR3-/- mice.	Lysine	91-93	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	150-156
19783674-0	2009	Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.	Lysine	15-22	lymphocyte antigen 96	Mus musculus	91-95
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Lysine	279-282	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Lysine	279-282	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73
20581823-4	2010	The structure, supported by mutation studies, defines how a lysine-rich basic cleft within the RIG-I CTD sequesters the observable 5"-pp of the bound RNA, with a stacked phenylalanine capping the terminal base pair.	Lysine	60-66	DExD/H-box helicase 58	Homo sapiens	95-100
19783674-4	2009	However, replacement of Glu122, Leu125, and/or Asn58 of mMD-2 with the corresponding residues (lysines) of hMD-2 was sufficient to yield soluble extracellular MD-2 that reacted with monomeric E .	Lysine	95-102	lymphocyte antigen 96	Mus musculus	56-61
19783674-4	2009	However, replacement of Glu122, Leu125, and/or Asn58 of mMD-2 with the corresponding residues (lysines) of hMD-2 was sufficient to yield soluble extracellular MD-2 that reacted with monomeric E .	Lysine	95-102	lymphocyte antigen 96	Mus musculus	57-61
20178071-1	2010	Silent information regulator two ortholog 1 (SIRT1) is a member of the sirtuin deacetylase family of enzymes that removes acetyl groups from the lysine residues in histones and other proteins.	Lysine	145-151	sirtuin 1	Homo sapiens	0-43
20178071-1	2010	Silent information regulator two ortholog 1 (SIRT1) is a member of the sirtuin deacetylase family of enzymes that removes acetyl groups from the lysine residues in histones and other proteins.	Lysine	145-151	sirtuin 1	Homo sapiens	45-50
19783674-10	2009	These findings reveal novel roles of lysines 122, 125, and 58 in human MD-2 that contribute to the functional differences between human and murine MD-2 and, potentially, to differences in the sensitivity of humans and mice to endotoxin.	Lysine	37-44	lymphocyte antigen 96	Mus musculus	71-75
30089852-4	2018	Here we show that the histone-lysine N-methyltransferase MLL1/WDR5 complexes physically interact with SOX2 and evoke SOX2 proteolysis, possibly through methylation on a potential site lysine 42 (K42).	Lysine	30-36	SRY-box transcription factor 2	Homo sapiens	102-106
19783674-10	2009	These findings reveal novel roles of lysines 122, 125, and 58 in human MD-2 that contribute to the functional differences between human and murine MD-2 and, potentially, to differences in the sensitivity of humans and mice to endotoxin.	Lysine	37-44	lymphocyte antigen 96	Mus musculus	147-151
30089852-4	2018	Here we show that the histone-lysine N-methyltransferase MLL1/WDR5 complexes physically interact with SOX2 and evoke SOX2 proteolysis, possibly through methylation on a potential site lysine 42 (K42).	Lysine	30-36	SRY-box transcription factor 2	Homo sapiens	117-121
20614009-5	2010	METHODS/PRINCIPAL FINDINGS: Here we demonstrate for the first time that BRCA1 is methylated both in breast cancer cell lines and breast cancer tumor samples at arginine and lysine residues through immunoprecipitation and western blot analysis.	Lysine	173-179	BRCA1 DNA repair associated	Homo sapiens	72-77
19597476-7	2009	In stressed cells, HSP27 enters the nucleus and, in the form of large oligomers, binds to HSF1 and induces its modification by SUMO-2/3 on lysine 298.	Lysine	139-145	heat shock protein family B (small) member 1	Homo sapiens	19-24
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	DExD/H-box helicase 58	Homo sapiens	101-106
20406818-2	2010	Upon recognition of viral RNA, TRIM25 E3 ligase binds the first caspase recruitment domain (CARD) of RIG-I and subsequently induces lysine 172 ubiquitination of the second CARD of RIG-I, which is essential for the interaction with downstream MAVS/IPS-1/CARDIF/VISA and, thereby, IFN-beta mRNA production.	Lysine	132-138	DExD/H-box helicase 58	Homo sapiens	180-185
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	sirtuin 7	Homo sapiens	12-17
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	97-100	sirtuin 7	Homo sapiens	56-61
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	sirtuin 7	Homo sapiens	12-17
30282801-6	2018	In summary, SIRT7 is a major deacetylase for WDR77, and SIRT7-mediated deacetylation of WDR77 at Lys-3 and Lys-243 weakens the WDR77-PRMT5 interaction and activity and thereby suppresses growth of cancer cells.	Lysine	107-110	sirtuin 7	Homo sapiens	56-61
30323061-4	2018	Transgenic GCN5L1 overexpression in the mouse liver increased protein acetylation levels, and proteomic detection of specific lysine residues identified numerous sites that are co-regulated by GCN5L1 and SIRT3.	Lysine	126-132	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	11-17
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	TNF receptor associated factor 6	Homo sapiens	0-5
30228186-0	2018	K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion.	Lysine	6-9	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
30228186-3	2018	In the current study, we further investigated the role of Lys-42 in regulating cellular activities of K-Ras.	Lysine	58-61	KRAS proto-oncogene, GTPase	Homo sapiens	102-107
20493168-6	2010	Phosphorylation of the chromodomain of Cbx2 on this residue in vitro resulted in a reduced level of binding to an H3 peptide containing trimethylated lysine-9 as well as an increase in the extent of binding to an H3 peptide containing trimethylated lysine-27, suggesting that such phosphorylation changes the binding specificity of Cbx2 for modified histone H3.	Lysine	150-156	chromobox 2	Mus musculus	39-43
20493168-6	2010	Phosphorylation of the chromodomain of Cbx2 on this residue in vitro resulted in a reduced level of binding to an H3 peptide containing trimethylated lysine-9 as well as an increase in the extent of binding to an H3 peptide containing trimethylated lysine-27, suggesting that such phosphorylation changes the binding specificity of Cbx2 for modified histone H3.	Lysine	249-255	chromobox 2	Mus musculus	39-43
20378541-8	2010	Lys residues in the C terminus of apoA-I were targeted for cross-linking in high yield, and this process may hinder the interaction of apoA-I with lipids and ABCA1, two key steps in reverse cholesterol transport.	Lysine	0-3	ATP binding cassette subfamily A member 1	Homo sapiens	158-163
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	ubiquitin conjugating enzyme E2 N	Homo sapiens	83-88
20498091-1	2010	The Rad6-Rad18 mediated monoubiquitylation of proliferating cell nuclear antigen (PCNA) at lys 164 plays a crucial role in promoting the access of translesion synthesis (TLS) DNA polymerases (Pols) to PCNA in the replication fork stalled at a lesion site.	Lysine	91-94	RAD18 E3 ubiquitin protein ligase	Homo sapiens	9-14
20378540-8	2010	These modifications preceded GH-stimulated recruitment of Stat5b, as did lysine 4 monomethylation of histone H3, which was enriched in 6/7 Stat5b-binding elements.	Lysine	73-79	signal transducer and activator of transcription 5B	Rattus norvegicus	139-145
30408026-7	2018	TRIM59 stabilized PDCD10 by suppressing RING finger and transmembrane domain-containing protein 1 (RNFT1)-induced lysine 63 (K63) ubiquitination and subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation.	Lysine	114-120	programmed cell death 10	Homo sapiens	18-24
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	ubiquitin conjugating enzyme E2 N	Homo sapiens	104-109
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	ubiquitin conjugating enzyme E2 V1	Homo sapiens	115-120
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	ubiquitin conjugating enzyme E2 V1	Homo sapiens	122-128
20523343-9	2010	Triptolide increased the protein expression of RIZ1 and RIZ1 methylates histone H3 lysine 9 in U266 cells.	Lysine	83-89	PR/SET domain 2	Homo sapiens	47-51
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	196-200
20523343-9	2010	Triptolide increased the protein expression of RIZ1 and RIZ1 methylates histone H3 lysine 9 in U266 cells.	Lysine	83-89	PR/SET domain 2	Homo sapiens	56-60
19675569-2	2009	TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex.	Lysine	142-145	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	216-222
30201799-0	2018	Acetylation of SUMO2 at lysine 11 favors the formation of non-canonical SUMO chains.	Lysine	24-30	small ubiquitin like modifier 2	Homo sapiens	15-20
19675569-5	2009	By reconstituting TAK1 activation in vitro using purified proteins, here we show that free Lys 63 polyubiquitin chains, which are not conjugated to any target protein, directly activate TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2).	Lysine	91-94	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	18-22
30201799-4	2018	SUMO chains typically form in response to genotoxic or proteotoxic stress and are preferentially linked via lysine 11 of SUMO2/3.	Lysine	108-114	small ubiquitin like modifier 2	Homo sapiens	121-126
19675569-5	2009	By reconstituting TAK1 activation in vitro using purified proteins, here we show that free Lys 63 polyubiquitin chains, which are not conjugated to any target protein, directly activate TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2).	Lysine	91-94	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	186-190
20053926-3	2010	Here, we show that the expression of claudin-3 and claudin-4 is repressed in ovarian epithelial cells in association with promoter "bivalent" histone modifications, containing both the activating trimethylated histone H3 lysine 4 (H3K4me3) mark and the repressive mark of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	221-227	claudin 3	Homo sapiens	37-46
19675569-5	2009	By reconstituting TAK1 activation in vitro using purified proteins, here we show that free Lys 63 polyubiquitin chains, which are not conjugated to any target protein, directly activate TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2).	Lysine	91-94	TGF-beta activated kinase 1 (MAP3K7) binding protein 2	Homo sapiens	248-257
20053926-3	2010	Here, we show that the expression of claudin-3 and claudin-4 is repressed in ovarian epithelial cells in association with promoter "bivalent" histone modifications, containing both the activating trimethylated histone H3 lysine 4 (H3K4me3) mark and the repressive mark of trimethylated histone H3 lysine 27 (H3K27me3).	Lysine	297-303	claudin 3	Homo sapiens	37-46
19700617-0	2009	CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.	Lysine	39-45	sarcoplasmic calcium-binding protein	Drosophila melanogaster	0-3
20399742-4	2010	Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.	Lysine	226-232	opioid receptor, delta 1	Mus musculus	265-268
20501938-0	2010	TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.	Lysine	23-29	beclin 1	Homo sapiens	58-66
30172749-9	2018	Mechanistically, HOTAIR inhibited p15 expression through zeste homolog 2 (EZH2)-enrolled tri-methylation of Lys 27 of histone H3 (H3K27me3) in p15 promoter.	Lysine	108-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	74-78
30217796-2	2018	We investigated the roles in epigenetic inheritance of MES-4 and MET-1, the two Caenorhabditis elegans enzymes that methylate H3K36 (histone H3 Lys 36).	Lysine	144-147	Histone-lysine N-methyltransferase	Caenorhabditis elegans	65-70
20501938-3	2010	We found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediated, Lys(63) (K63)-linked ubiquitination of Beclin-1 is critical for TLR4-triggered autophagy in macrophages.	Lysine	90-93	beclin 1	Homo sapiens	129-137
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	fibronectin 1	Mus musculus	219-230
20501938-5	2010	Lys(117), which is strategically located in the Bcl-2 homology 3 (BH3) domain of Beclin-1, was a major site for K63-linked ubiquitination.	Lysine	0-3	beclin 1	Homo sapiens	81-89
20308360-5	2010	In prostate cancer (PCa) tissues, HP1beta expressions correlated with Gleason score and tri-methylation levels of histone H3 lysine 9.	Lysine	125-131	chromobox 1	Homo sapiens	34-41
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	runt related transcription factor 2	Mus musculus	232-238
29656413-7	2018	Furthermore, sequence alignment and amino acid composition revealed that Cra g 1 shared relatively high homology to tropomyosins from other shellfish and was also abundant in lysine that was apt to be modified by reducing sugars during heating.	Lysine	175-181	myotubularin related protein 11	Homo sapiens	73-76
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	246-262
29856240-1	2018	Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 plays important roles in maintaining genome integrity and surviving DNA damage.	Lysine	26-32	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	93-99
30405658-0	2018	WHIRLY1 Occupancy Affects Histone Lysine Modification and WRKY53 Transcription in Arabidopsis Developmental Manner.	Lysine	34-40	ssDNA-binding transcriptional regulator	Arabidopsis thaliana	0-7
30006145-2	2018	We previously developed a chemical catalyst, DSH, which activates a chemically stable thioester including acyl-CoA, allowing the site-selective lysine acylation of histones under physiological conditions.	Lysine	144-150	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	45-48
30006145-4	2018	We, herein, conducted a kinetic analysis of the ability of DSH and several derivatives to mediate lysine acetylation to better understand the structural elements essential for high acetylation activity under physiological conditions.	Lysine	98-104	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	59-62
30364220-2	2018	Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a crucial element in the expression of inflammatory cytokines.	Lysine	59-65	lysine demethylase 6B	Rattus norvegicus	0-27
30364220-2	2018	Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a crucial element in the expression of inflammatory cytokines.	Lysine	59-65	lysine demethylase 6B	Rattus norvegicus	29-34
30118695-7	2018	In the study, we used both in situ prediction algorithms and mass spectrometry based post-translational modification analysis to map the lysine residues in MTA-1 that are polyubiquitinated.	Lysine	137-143	metastasis associated 1	Homo sapiens	156-161
30118695-14	2018	We establish that TRIM25 ubiquitinates MTA-1 at lysine 98 and degrades it normal liver cells.	Lysine	48-54	metastasis associated 1	Homo sapiens	39-44
30028960-3	2018	We also want to investigate the downstream effects of SIRT1 activation by measuring the trimethylation of histone 3 at lysine 9 (H3K9me3).	Lysine	119-125	sirtuin 1	Homo sapiens	54-59
29562800-3	2018	The tandem tudor domain (TTD) of UHRF1 specifically and tightly binds to histone H3 di- or trimethylated at lysine 9 (H3K9me2 or H3K9me3, respectively), and this binding is essential for UHRF1 function.	Lysine	108-114	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	33-38
29562800-3	2018	The tandem tudor domain (TTD) of UHRF1 specifically and tightly binds to histone H3 di- or trimethylated at lysine 9 (H3K9me2 or H3K9me3, respectively), and this binding is essential for UHRF1 function.	Lysine	108-114	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	187-192
29447112-2	2018	CDCP1 is cleaved by serine proteases at adjacent sites, arginine 368 (R368) and lysine 369 (K369), which induces cell migration in vitro and metastasis in vivo.	Lysine	80-86	CUB domain containing protein 1	Homo sapiens	0-5
30249103-0	2018	Ku70 N-terminal lysines acetylation/deacetylation is required for radiation-induced DNA-double strand breaks repair.	Lysine	16-23	X-ray repair cross complementing 6	Homo sapiens	0-4
30249103-4	2018	To address these questions aceto-blocking and aceto-mimicking mutants were designed by replacing Ku70 lysine residues K317, K331 and K338 with arginine and glutamine respectively via site-directed mutagenesis.	Lysine	102-108	X-ray repair cross complementing 6	Homo sapiens	97-101
30249103-9	2018	Our data indicates that dynamic equilibrium of acetylation/deacetylation of Ku70 lysine residues K317, K331 and K338 is critical for optimal repair of IR-induced DSBs, and may offer a novel therapeutic approach for cancer treatment.	Lysine	81-87	X-ray repair cross complementing 6	Homo sapiens	76-80
29853448-9	2018	After IL-12 stimulation, both STAT1 and STAT4 directly bound on BCL6 and TBX21 gene loci accompanied by suppression of repressive histone mark trimethylated histone 3 lysine 27.	Lysine	167-173	signal transducer and activator of transcription 1	Homo sapiens	30-35
29853448-9	2018	After IL-12 stimulation, both STAT1 and STAT4 directly bound on BCL6 and TBX21 gene loci accompanied by suppression of repressive histone mark trimethylated histone 3 lysine 27.	Lysine	167-173	signal transducer and activator of transcription 4	Homo sapiens	40-45
29853448-9	2018	After IL-12 stimulation, both STAT1 and STAT4 directly bound on BCL6 and TBX21 gene loci accompanied by suppression of repressive histone mark trimethylated histone 3 lysine 27.	Lysine	167-173	BCL6 transcription repressor	Homo sapiens	64-68
29807073-1	2018	Tumor suppressor cylindromatosis protein (CYLD), which specifically cleaves lysine 63-linked ubiquitin chain from its substrate molecules, contributes to myriad of important cellular events including cellular differentiation, oncogenesis, DNA repair and cell cycle control.	Lysine	76-82	CYLD lysine 63 deubiquitinase	Homo sapiens	42-46
29920190-1	2018	Lysine-63-linked (K63-linked) polyubiquitination of TRAF3 coordinates the engagement of pattern-recognition receptors with recruited adaptor proteins and downstream activator TBK1 in pathways that induce type I IFN.	Lysine	0-6	TNF receptor-associated factor 3	Mus musculus	52-57
30170615-3	2018	In contrast to global loss of both H3 lysine 27 trimethylation (H3K27m3) and histone H2A lysine 119 monoubiquitylation (H2AK119ub1) we observed upon Xist deletion, alterations in CpG methylation were subtle, and this was mirrored by only minor alterations in X-chromosome-wide gene expression levels, with highly expressed genes more prone to both derepression and demethylation compared to genes with low expression level.	Lysine	89-95	inactive X specific transcripts	Mus musculus	149-153
30104358-2	2018	The DNA methylation maintenance function of UHRF1 is dependent on its ability to bind chromatin, where it facilitates monoubiquitination of histone H3 at lysines 18 and 23, a docking site for DNMT1.	Lysine	154-161	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	44-49
30104358-2	2018	The DNA methylation maintenance function of UHRF1 is dependent on its ability to bind chromatin, where it facilitates monoubiquitination of histone H3 at lysines 18 and 23, a docking site for DNMT1.	Lysine	154-161	DNA methyltransferase 1	Homo sapiens	192-197
30104358-5	2018	We show that multivalent engagement of nucleosomal linker DNA and dimethylated lysine 9 on histone H3 directs UHRF1 ubiquitin ligase activity toward histone substrates.	Lysine	79-85	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	110-115
29899112-2	2018	Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of zeste homolog 2 (EZH2) in WT mice enhances osteogenesis and stimulates bone formation.	Lysine	44-47	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	77-104
29899112-2	2018	Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of zeste homolog 2 (EZH2) in WT mice enhances osteogenesis and stimulates bone formation.	Lysine	44-47	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	106-110
29853605-10	2018	Increased levels of histone 3, lysine 9 acetylation, a marker of open chromatin, were manifest in tumor macrophages of OdcDeltamye mice, consistent with our findings that macrophage ODC affects histone modifications that upregulate M1 gene transcription during GI infections.	Lysine	31-37	ornithine decarboxylase, structural 1	Mus musculus	182-185
29773900-7	2018	More importantly, GCN5-mediated KLF5 acetylation contributing to GDF15 gene transcription and cell proliferation upon C5a stimulation, the region (-103 to +58 nt) of GDF15 promoter which KLF5 could bind to, and two new KLF5 lysine sites (K335 and K391) acetylated by GCN5 were identified for the first time.	Lysine	224-230	lysine acetyltransferase 2A	Homo sapiens	18-22
30065264-7	2018	GM-CSF driven myeloid cells link peripheral insulin sensitivity to adiposity via lysine metabolism involving DHTKD1/2-AA axis in a diet independent manner.	Lysine	81-87	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
30065264-7	2018	GM-CSF driven myeloid cells link peripheral insulin sensitivity to adiposity via lysine metabolism involving DHTKD1/2-AA axis in a diet independent manner.	Lysine	81-87	dehydrogenase E1 and transketolase domain containing 1	Mus musculus	109-115
29762786-6	2018	Increasing SID Lys increased (linear, P &lt; 0.05) ADG, feed efficiency (G:F), final weight, and HCW.	Lysine	15-18	ADG	Sus scrofa	51-54
29762786-14	2018	Pigs fed 100% of the SID Lys requirement had increased (P &lt; 0.05) ADG, G:F, and final weight compared with those fed 92.5%.	Lysine	25-28	ADG	Sus scrofa	69-72
29860315-3	2018	The lysine methyltransferases G9a and GLP directly bound to the alpha subunit of HIF-1 (HIF-1alpha) and catalyzed mono- and di-methylation of HIF-1alpha at lysine (K) 674 in vitro and in vivo.	Lysine	4-10	euchromatic histone lysine methyltransferase 2	Homo sapiens	30-33
30026585-0	2018	SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.	Lysine	58-64	sirtuin 7	Mus musculus	0-5
30026585-0	2018	SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.	Lysine	58-64	Sp7 transcription factor 7	Mus musculus	78-89
30026585-3	2018	Here, we report that sirtuins, which are NAD(+)-dependent deacylases, regulate lysine deacylation-mediated transactivation of OSX.	Lysine	79-85	Sp7 transcription factor 7	Mus musculus	126-129
30026585-7	2018	Deacylation of lysine (K) 368 in the C-terminal region of OSX by SIRT7 promote its N-terminal transactivation activity.	Lysine	15-21	Sp7 transcription factor 7	Mus musculus	58-61
30026585-7	2018	Deacylation of lysine (K) 368 in the C-terminal region of OSX by SIRT7 promote its N-terminal transactivation activity.	Lysine	15-21	sirtuin 7	Mus musculus	65-70
29770599-2	2018	The bromodomains of BAZ2A and BAZ2B have a similar binding site for their natural ligand, the acetylated lysine side chain.	Lysine	105-111	bromodomain adjacent to zinc finger domain 2B	Homo sapiens	30-35
30005706-2	2018	EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes.	Lysine	79-85	embryonic ectoderm development	Homo sapiens	0-3
29851470-7	2018	Our data also reveal that lysine residues in the nuclear localization sequence of PTBP2 are acetylated.	Lysine	26-32	polypyrimidine tract binding protein 2	Homo sapiens	82-87
29968790-3	2018	With this in mind, we have developed heritable Cas9-mediated mammalian genome editing that is acutely controlled by the cheap lysine derivative, Lys(Boc) (BOC).	Lysine	126-132	BOC cell adhesion associated, oncogene regulated	Homo sapiens	145-153
29970601-7	2018	In addition, lysine motifs were necessary for promoting the S-nitrosylation of HDAC2 and methyl-CpG binding protein 3 (MBD3).	Lysine	13-19	methyl-CpG binding domain protein 3	Rattus norvegicus	89-117
29970601-7	2018	In addition, lysine motifs were necessary for promoting the S-nitrosylation of HDAC2 and methyl-CpG binding protein 3 (MBD3).	Lysine	13-19	methyl-CpG binding domain protein 3	Rattus norvegicus	119-123
29808031-1	2018	ABSTACT: Polycomb-mediated repression of gene expression is essential for development, with a pivotal role played by trimethylation of histone H3 lysine 27 (H3K27me3), which is deposited by Polycomb Repressive Complex 2 (PRC2).	Lysine	146-152	chromobox 2	Mus musculus	9-17
29808031-1	2018	ABSTACT: Polycomb-mediated repression of gene expression is essential for development, with a pivotal role played by trimethylation of histone H3 lysine 27 (H3K27me3), which is deposited by Polycomb Repressive Complex 2 (PRC2).	Lysine	146-152	chromobox 2	Mus musculus	190-198
29807585-0	2018	Marker-assisted pyramiding of opaque2 and novel opaque16 genes for further enrichment of lysine and tryptophan in sub-tropical maize.	Lysine	89-95	regulatory protein opaque-2	Zea mays	30-37
30456351-4	2018	Here, we show that SYCE2 constitutively insulates HP1alpha from trimethylated histone H3 lysine 9 (H3K9me3) to promote DNA double-strand break repair.	Lysine	89-95	synaptonemal complex central element protein 2	Homo sapiens	19-24
29916805-1	2018	Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene.	Lysine	89-95	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	64-73
29661920-1	2018	DHTKD1, a part of 2-ketoadipic acid dehydrogenase complex, is involved in lysine and tryptophan catabolism.	Lysine	74-80	dehydrogenase E1 and transketolase domain containing 1	Mus musculus	0-6
29394130-1	2018	MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines.	Lysine	132-139	MDM2 proto-oncogene	Homo sapiens	0-4
29691138-4	2018	A co-crystal structure of KDM4A TUDOR domain in complex with 1a shows that the fragment binds stereo-specifically to the methyl lysine binding pocket forming a network of strong hydrogen bonds and hydrophobic interactions.	Lysine	128-134	lysine demethylase 4A	Homo sapiens	26-31
29574020-6	2018	Silent Inflammation Regulator 2 (SIR2) proteins-sirtuins- are a family of histone deacetylases (HDACs) that catalyze deacetylation of both histone and non- histone lysine residues.	Lysine	164-170	sirtuin 1	Homo sapiens	0-31
29574020-6	2018	Silent Inflammation Regulator 2 (SIR2) proteins-sirtuins- are a family of histone deacetylases (HDACs) that catalyze deacetylation of both histone and non- histone lysine residues.	Lysine	164-170	sirtuin 1	Homo sapiens	33-37
27549815-5	2018	Molecular docking reveals the binding interaction of beta-catenin and ganoderic acid A with GScore (-9.44), kcal/mol, lipophilic EvdW (-2.86), electro (-0.72), Glide emodel (-50.401), MM-GBSA (-87.441), H bond (-1.91) with Lys 180 and Asn 220 residues involved in hydrogen bonding.	Lysine	223-226	catenin (cadherin associated protein), beta 1	Mus musculus	53-65
29512944-4	2018	Biotinylated oxytocin bridged with five lysine residues was used in a competitive format.	Lysine	40-46	oxytocin/neurophysin I prepropeptide	Homo sapiens	13-21
28894299-5	2018	The latter induces the expression of the histone 3 lysine 27 (H3K27) demethylase Jumonji d3 (Jmjd3), which thereby controls the expression of inflammation-related genes and microglial polarization.	Lysine	51-57	lysine demethylase 6B	Homo sapiens	93-98
29858084-9	2018	Ultimately, miR372 promotes the expression of erbB-2 through PKM2-pH3T11-acetylation on histone H3 lysine 9 (H3K9Ac) pathway.	Lysine	99-105	microRNA 372	Homo sapiens	12-18
29789597-2	2018	The histone H3 lysine 27 (H3K27) trimethylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and regulates immunity, also involves pathogenesis of several liver diseases.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	56-83
29789597-2	2018	The histone H3 lysine 27 (H3K27) trimethylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and regulates immunity, also involves pathogenesis of several liver diseases.	Lysine	15-21	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	85-89
29776446-3	2018	Lysine acetylation of STAT1 seems necessary for NF-kB pathway activity, as it is regulated by histone deacetylases (HDACs).	Lysine	0-6	signal transducer and activator of transcription 1	Homo sapiens	22-27
29511087-8	2018	The alanine-scanning experiments revealed that residues Tyr-34, Gln-38, Gly-39, and Leu-45 (in the AB loop) and Pro-153 (in the D-helix) had specific roles in activating OSMR but not LIFR signaling, whereas Leu-40 and Cys-49 (in the AB loop), and Phe-160 and Lys-163 (in the D-helix) were required for activation of both receptors.	Lysine	259-262	oncostatin M receptor	Homo sapiens	170-174
29545352-5	2018	The associations of this SLC7A9 variant with ratios of lysine to specific neutral amino acids were much stronger than the association with lysine concentration alone.	Lysine	55-61	solute carrier family 7 member 9	Homo sapiens	25-31
29545352-5	2018	The associations of this SLC7A9 variant with ratios of lysine to specific neutral amino acids were much stronger than the association with lysine concentration alone.	Lysine	139-145	solute carrier family 7 member 9	Homo sapiens	25-31
29695657-6	2018	Importantly, the IL-6 gene promoter contains a single nucleotide polymorphism (SNP), -572C/G, and ICAM-1 gene contains a SNP (A/G) in the protein-coding region, Lys (AAG)/Glu (GAG) at codon 469, known as K469E polymorphism.	Lysine	161-164	intercellular adhesion molecule 1	Homo sapiens	98-104
32704699-10	2018	Thus, pigs fed the high Lys level during phase 3, regardless of previous Lys levels in phases 1 and 2, had greater (P < 0.05) overall ADG and G:F compared with other treatment groups.	Lysine	24-27	ADG	Sus scrofa	134-137
29176272-8	2018	This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45).	Lysine	78-81	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	52-57
29053336-2	2018	We have previously reported that histone deacetylation and histone H3 lysine 9 (H3K9) methylation are involved in CXCL10 repression.	Lysine	70-76	C-X-C motif chemokine ligand 10	Homo sapiens	114-120
20498723-5	2010	Methylation of lysine 9 in histone H3 (H3-K9) by members of the Su(var)3-9 family of histone methyltransferases (HMTs) triggers embryonic DNA methylation in Arthropods and Chordates.	Lysine	15-21	Suppressor of variegation 3-9	Drosophila melanogaster	64-74
20379134-2	2010	The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear.	Lysine	72-75	lysine demethylase 2A	Homo sapiens	16-21
20379134-2	2010	The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear.	Lysine	72-75	lysine demethylase 2A	Homo sapiens	22-28
20379134-2	2010	The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono- and dimethylated Lys 36 of histone H3, but its function is unclear.	Lysine	72-75	lysine demethylase 2A	Homo sapiens	29-35
20379134-8	2010	The knockdown of KDM2A increased mono- and dimethylated Lys 36 of histone H3 marks, and suppressed the reduction of ribosomal RNA transcription under starvation.	Lysine	56-59	lysine demethylase 2A	Homo sapiens	17-22
20363980-7	2010	We found that escape genes are marked by the absence of trimethylation at lysine 27 of histone H3, a chromatin modification associated with genes subject to X inactivation.	Lysine	74-80	H3 clustered histone 7	Mus musculus	87-97
20181693-4	2010	We found that NL63 PLP2 deconjugated ubiquitin (Ub) and the Ub-line molecule ISG15 from cellular substrates and processed both lysine-48- and lysine-63- linked polyubiquitin chains.	Lysine	127-133	proteolipid protein 2	Homo sapiens	19-23
20181693-4	2010	We found that NL63 PLP2 deconjugated ubiquitin (Ub) and the Ub-line molecule ISG15 from cellular substrates and processed both lysine-48- and lysine-63- linked polyubiquitin chains.	Lysine	142-148	proteolipid protein 2	Homo sapiens	19-23
20449481-1	2010	Antimicrobially active cycloundecapeptides related to gramicidin S, cyclo(-Val1-Orn2-Leu3-X4-D-Phe5-Pro6-Val7-Orn8- Leu9-D-Phe10-Pro11-) (X= Leu (1), Ala (2), Orn (3), Lys (4) and Arg (5)), were synthesized.	Lysine	168-171	CD7 molecule	Homo sapiens	116-120
20419159-6	2010	We show that K5 targets a single lysine (K18) in the cytoplasmic tail of tetherin for ubiquitination, leading to relocalization of tetherin to CD63-positive endosomal compartments.	Lysine	33-39	bone marrow stromal cell antigen 2	Homo sapiens	73-81
20419159-6	2010	We show that K5 targets a single lysine (K18) in the cytoplasmic tail of tetherin for ubiquitination, leading to relocalization of tetherin to CD63-positive endosomal compartments.	Lysine	33-39	bone marrow stromal cell antigen 2	Homo sapiens	131-139
20419159-9	2010	By contrast, while Vpu induces ubiquitination of tetherin cytoplasmic tail lysine residues, mutation of these positions has no effect on its antagonism of tetherin function, and residual tetherin is associated with the trans-Golgi network (TGN) in Vpu-expressing cells.	Lysine	75-81	bone marrow stromal cell antigen 2	Homo sapiens	49-57
20233307-10	2010	This position is under strong positive selection, suggesting that the cysteine/lysine mutation might be a key step driving the evolution of HopZ1.	Lysine	79-85	D708_p022	Pseudomonas syringae	140-145
20106972-7	2010	Indeed, our NMR solution structure of the EHD1 EH-domain in complex with the MICAL-L1 NPFEEEEED peptide indicates that the first two flanking Glu residues lie in a position favorable to form salt bridges with Lys residues within the EH-domain.	Lysine	209-212	MICAL like 1	Homo sapiens	77-85
20065036-5	2010	A search for auxiliary factors required for transcript elongation through the heterochromatic locus revealed that two proteins involved in histone H3 lysine 56 acetylation, Rtt109 and Asf1, are needed for efficient transcript elongation by RNAPII.	Lysine	150-156	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	173-179
20065036-5	2010	A search for auxiliary factors required for transcript elongation through the heterochromatic locus revealed that two proteins involved in histone H3 lysine 56 acetylation, Rtt109 and Asf1, are needed for efficient transcript elongation by RNAPII.	Lysine	150-156	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	184-188
20188666-3	2010	Here we show that Gcn5, a KAT that functions in transcription, works in parallel with Rtt109, the H3 lysine 56 KAT, to promote RC nucleosome assembly.	Lysine	101-107	lysine acetyltransferase 2A	Homo sapiens	18-22
20159555-8	2010	DNAJB8 is (de)acetylated at two conserved C-terminal lysines that are not involved in substrate binding, but do play a role in suppressing protein aggregation.	Lysine	53-60	DnaJ heat shock protein family (Hsp40) member B8	Homo sapiens	0-6
19914676-0	2010	Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs.	Lysine	41-47	sirtuin 1	Homo sapiens	25-30
19914676-2	2010	While previous studies showed that the side chain acetyl group of L-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine N(epsilon)-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the alpha-carbon and the side chain acetamido group, with that found in L-AcK being optimal.	Lysine	148-154	sirtuin 1	Homo sapiens	131-136
19914676-2	2010	While previous studies showed that the side chain acetyl group of L-AcK can be extended to bulkier acyl groups for Sir2 (including SIRT1)-catalyzed lysine N(epsilon)-deacylation reaction, our current study suggested that SIRT1-catalyzed deacetylation reaction had a very stringent requirement for the distance between the alpha-carbon and the side chain acetamido group, with that found in L-AcK being optimal.	Lysine	148-154	sirtuin 1	Homo sapiens	221-226
19927155-8	2010	The same lysines are also targets of MDM2-mediated ubiquitination.	Lysine	9-16	MDM2 proto-oncogene	Homo sapiens	37-41
19936620-5	2010	In vitro ATAC complexes acetylate lysine 14 of histone H3.	Lysine	34-40	X-C motif chemokine ligand 1	Homo sapiens	9-13
20546268-4	2010	Although lysine 185 is predicted to be a major contributor to the ATP-binding site of Kir6.2, no mutations at this residue have been found to cause neonatal diabetes to date.	Lysine	9-15	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	86-92
20081815-3	2010	They react chemoselectively with only one of eight lysine e-amino groups within transthyretin.	Lysine	51-57	transthyretin	Homo sapiens	80-93
19923226-4	2010	Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79 and resulted in significant sensitivity to 6-azauracil and mycophenolic acid.	Lysine	62-68	LARGE xylosyl- and glucuronyltransferase 1	Homo sapiens	14-18
19923226-4	2010	Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79 and resulted in significant sensitivity to 6-azauracil and mycophenolic acid.	Lysine	95-102	LARGE xylosyl- and glucuronyltransferase 1	Homo sapiens	14-18
20023629-5	2010	USP9X binds MCL1 and removes the Lys 48-linked polyubiquitin chains that normally mark MCL1 for proteasomal degradation.	Lysine	33-36	ubiquitin specific peptidase 9 X-linked	Homo sapiens	0-5
21502408-4	2010	PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response.	Lysine	57-63	H4 clustered histone 9	Homo sapiens	70-80
19875498-3	2010	To elucidate the physiological functions, we generated the knockout mouse model of dimethylated or monomethylated histone 3 lysine 9 (H3K9me2/1)-specific JmjC domain-containing histone demethylase 2A (JHDM2A; also known as JMJD1A and KDM3A) and showed that JHDM2A is essential for spermatogenesis.	Lysine	124-130	lysine (K)-specific demethylase 3A	Mus musculus	154-199
19875498-3	2010	To elucidate the physiological functions, we generated the knockout mouse model of dimethylated or monomethylated histone 3 lysine 9 (H3K9me2/1)-specific JmjC domain-containing histone demethylase 2A (JHDM2A; also known as JMJD1A and KDM3A) and showed that JHDM2A is essential for spermatogenesis.	Lysine	124-130	lysine (K)-specific demethylase 3A	Mus musculus	201-207
19875498-3	2010	To elucidate the physiological functions, we generated the knockout mouse model of dimethylated or monomethylated histone 3 lysine 9 (H3K9me2/1)-specific JmjC domain-containing histone demethylase 2A (JHDM2A; also known as JMJD1A and KDM3A) and showed that JHDM2A is essential for spermatogenesis.	Lysine	124-130	lysine (K)-specific demethylase 3A	Mus musculus	223-229
19875498-3	2010	To elucidate the physiological functions, we generated the knockout mouse model of dimethylated or monomethylated histone 3 lysine 9 (H3K9me2/1)-specific JmjC domain-containing histone demethylase 2A (JHDM2A; also known as JMJD1A and KDM3A) and showed that JHDM2A is essential for spermatogenesis.	Lysine	124-130	lysine (K)-specific demethylase 3A	Mus musculus	234-239
19875498-3	2010	To elucidate the physiological functions, we generated the knockout mouse model of dimethylated or monomethylated histone 3 lysine 9 (H3K9me2/1)-specific JmjC domain-containing histone demethylase 2A (JHDM2A; also known as JMJD1A and KDM3A) and showed that JHDM2A is essential for spermatogenesis.	Lysine	124-130	lysine (K)-specific demethylase 3A	Mus musculus	257-263
20616536-4	2010	Here, we show that Drosophila STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells.	Lysine	70-76	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	30-37
20616536-4	2010	Here, we show that Drosophila STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells.	Lysine	70-76	smt3	Drosophila melanogaster	53-57
20053725-0	2010	A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation.	Lysine	12-18	thyroid hormone receptor alpha	Homo sapiens	26-57
20002879-5	2010	We also show that distinct mechanisms of UapA endocytosis necessitate ubiquitination of a single Lys residue (K572) by HulA(Rsp5).	Lysine	97-100	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	124-128
19934257-4	2010	SIRT1 deacetylates APE1 in vitro and in vivo targeting lysines 6 and 7.	Lysine	55-62	sirtuin 1	Homo sapiens	0-5
19934257-5	2010	Genotoxic insults stimulate lysine acetylation of APE1 which is antagonized by transcriptional upregulation of SIRT1.	Lysine	28-34	sirtuin 1	Homo sapiens	111-116
20046871-7	2009	Additionally, we found that Ap2delta is necessary for the recruitment of Ash2l-containing complexes to this promoter and that this recruitment leads to trimethylation of lysine 4 of histone H3 (H3K4me3).	Lysine	170-176	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	73-78
20018712-3	2009	Although recent biochemical studies have revealed that Dnmt3L binds to the tail of histone H3 with unmethylated lysine 4 in vitro, the requirement of chromatin components for DNA methylation has not been examined, and functional evidence for the connection of histone tails to DNA methylation is still lacking.	Lysine	112-118	DNA (cytosine-5-)-methyltransferase 3-like	Mus musculus	55-61
20018712-8	2009	The methylation activity of Dnmt3a largely depends on the Dnmt3L"s PHD domain recognizing the histone H3 tail with unmethylated lysine 4.	Lysine	128-134	DNA (cytosine-5-)-methyltransferase 3-like	Mus musculus	58-64
19800870-1	2009	Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes.	Lysine	94-100	lysine acetyltransferase 5	Homo sapiens	0-30
19800870-1	2009	Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes.	Lysine	94-100	lysine acetyltransferase 5	Homo sapiens	32-37
19877718-5	2009	Replacement of a central Gly in the neuromodulin IQ domain with a Lys at this position in PEP19 almost entirely accounts for the distinctive patterns of Ca(2+)-dependent stability changes exhibited by the two complexes.	Lysine	66-69	Purkinje cell protein 4	Homo sapiens	90-95
19877718-6	2009	Replacement of a Lys immediately before the "IQ" amino acid pair in the neuromodulin sequence with the Ala in PEP19 accounts for the remaining Ca(2+)-dependent differences.	Lysine	17-20	Purkinje cell protein 4	Homo sapiens	110-115
19822522-1	2009	Ubiquitylation of histone H2B and/or a component of the system that ubiquitylates H2B is required for methylation of histone H3 at lysine 4 (H3K4) in yeasts and probably in humans.	Lysine	131-137	histone H2B	Saccharomyces cerevisiae S288C	18-29
19822522-2	2009	In this study, the single ubiquitylation site was mapped to conserved lysine 115 of the C-terminal region of histone H2B in the single-cell model organism Tetrahymena thermophila.	Lysine	70-76	histone H2B	Saccharomyces cerevisiae S288C	109-120
19926860-1	2009	The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood.	Lysine	48-54	ubiquitin-conjugating enzyme E2N	Mus musculus	33-38
19926860-1	2009	The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood.	Lysine	48-54	ubiquitin-conjugating enzyme E2N	Mus musculus	191-196
19863064-0	2009	Lysine-60 in copper chaperone Atox1 plays an essential role in adduct formation with a target Wilson disease domain.	Lysine	0-6	antioxidant 1 copper chaperone	Homo sapiens	30-35
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	Vif	Human immunodeficiency virus 1	180-183
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	116-119	Vif	Human immunodeficiency virus 1	180-183
19887642-5	2009	In our model, the critical four Lys residues cluster at the C terminus, opposite to the known N-terminal Vif-interaction region in the protein.	Lysine	32-35	Vif	Human immunodeficiency virus 1	105-108
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	88-94	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	51-55
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	88-94	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	60-64
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	109-115	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	51-55
19586614-6	2009	We show that TNF also stimulates ubiquitination of MLK3 and MLK3 can be conjugated with lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitin chains.	Lysine	109-115	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	60-64
19822740-4	2009	While in adult cells G9a maintains E(y) in a repressed state via dimethylation of histone H3 at lysines 9 and 27, it activates beta(maj) transcription in a methyltransferase-independent manner.	Lysine	96-103	euchromatic histone lysine methyltransferase 2	Homo sapiens	21-24
19766637-0	2009	Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin.	Lysine	71-74	inhibitor of kappaB kinase gamma	Mus musculus	25-29
19766637-2	2009	The C-terminal leucine zipper of NEMO and its adjacent coiled-coil region (CC2-LZ) reportedly bind to linear ubiquitin chains with 1 microM affinity and to Lys 63-linked chains with 100 microM affinity.	Lysine	156-159	inhibitor of kappaB kinase gamma	Mus musculus	33-37
19766637-3	2009	Here we report the crystal structure of the CC2-LZ region of mouse NEMO in complex with Lys 63-linked di-ubiquitin (K63-Ub(2)) at 2.7A resolution.	Lysine	88-91	inhibitor of kappaB kinase gamma	Mus musculus	67-71
19805045-3	2009	We now report that the anaphase-promoting complex (APC/C) recognizes a D-box motif of Dvl and ubiquitylates Dvl on a highly conserved lysine residue.	Lysine	134-140	dishevelled segment polarity protein 2 L homeolog	Xenopus laevis	108-111
19825828-4	2009	Through the use of the Ubc13-Uev1A E2 complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling.	Lysine	65-71	interleukin 17A	Mus musculus	175-180
19825828-6	2009	We also showed that the lysine-124 residue of TRAF6 was critical for efficient Act1-mediated ubiquitination of TRAF6 and for the ability of TRAF6 to mediate IL-17-induced activation of nuclear factor kappaB.	Lysine	24-30	interleukin 17A	Mus musculus	157-162
19811652-3	2009	RESULTS: Here, we show that ERG-associated protein with SET domain (ESET), a histone methyltransferase enzyme, maintains pluripotency through repression of Cdx2, a key trophectoderm determinant, by histone H3 lysine 9 trimethylation (H3K9me3) of the promoter region.	Lysine	209-215	caudal type homeobox 2	Homo sapiens	156-160
19402140-2	2009	To enhance the adhesion of cells and to induce their differentiation into osteoblasts poly-L-lysine and BMP-2 were coupled to polymers and copolymers based on 2-deoxy-N-methacrylamido-D-glucose (ox.p(MAG) and p(MVA)) used as spacer, which were adsorbed onto the ceramic surface.	Lysine	86-99	myelin associated glycoprotein	Homo sapiens	200-203
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	13-19	parathyroid hormone 1 receptor	Sus scrofa	81-86
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	13-19	LOC100153898	Sus scrofa	165-170
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	13-19	LOC100153898	Sus scrofa	191-196
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	29-35	parathyroid hormone 1 receptor	Sus scrofa	81-86
19751687-2	2009	A DNA aptamer generated by in vitro selection to be highly specific for histone H4 protein acetylated at lysine 16 was used as a recognition element for atomic force microscopy-based recognition imaging of synthetic nucleosomal arrays with precisely controlled acetylation.	Lysine	105-111	H4 clustered histone 9	Homo sapiens	72-82
19553338-3	2009	During infections with viral mutants containing lysine substitutions or the methylation inhibitor adenosine dialdehyde, the interaction of ICP27 with SRPK1 and Aly/REF was decreased, as determined by coimmunoprecipitation and colocalization studies, indicating that ICP27 RGG box methylation regulates interaction with these proteins.	Lysine	48-54	Aly/REF export factor	Homo sapiens	160-167
19536136-0	2009	Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80.	Lysine	45-48	ubiquitin interaction motif containing 1	Homo sapiens	98-103
19536136-1	2009	RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs).	Lysine	148-151	ubiquitin interaction motif containing 1	Homo sapiens	0-5
19536136-1	2009	RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs).	Lysine	148-151	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	55-61
19536136-1	2009	RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs).	Lysine	148-151	BRCA1 DNA repair associated	Homo sapiens	62-67
19536136-1	2009	RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs).	Lysine	148-151	BRCA1 associated RING domain 1	Homo sapiens	68-73
19536136-2	2009	Here, we report the crystal structure of the RAP80 tandem UIMs (RAP80-UIM1-UIM2) in complex with Lys 63-linked di-ubiquitin at 2.2 A resolution.	Lysine	97-100	ubiquitin interaction motif containing 1	Homo sapiens	45-50
19536136-2	2009	Here, we report the crystal structure of the RAP80 tandem UIMs (RAP80-UIM1-UIM2) in complex with Lys 63-linked di-ubiquitin at 2.2 A resolution.	Lysine	97-100	ubiquitin interaction motif containing 1	Homo sapiens	64-69
19536136-8	2009	Further, we show that the Epsin1 tandem UIM, which has an inter-UIM region similar to that of RAP80-UIM1-UIM2, also selectively binds Lys 63-linked di-ubiquitin.	Lysine	134-137	ubiquitin interaction motif containing 1	Homo sapiens	94-99
19717977-2	2009	An interaction between EZH2 of the Polycomb repressive complex 2 (PRC2), which trimethylates lysine 27 on Histone 3 (H3K27me3), and all three DNA methyltransferases (DNMTs) has been reported, implicating a role for PRC2 in directing DNA methylation.	Lysine	93-99	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	23-27
19717977-2	2009	An interaction between EZH2 of the Polycomb repressive complex 2 (PRC2), which trimethylates lysine 27 on Histone 3 (H3K27me3), and all three DNA methyltransferases (DNMTs) has been reported, implicating a role for PRC2 in directing DNA methylation.	Lysine	93-99	chromobox 2	Mus musculus	35-43
19666585-3	2009	The role of H4 lysine 16 deacetylation is well established in Sir3 protein recruitment; however, that of the H3 N-terminal tail has remained unclear.	Lysine	15-21	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	62-66
19575012-4	2009	Polycomb group proteins (PcGs) co-operatively silence genes by laying down repressive marks such as histone H3 lysine 27 trimethylation (H3K27me3), which can be removed by specific demethylases.	Lysine	111-117	chromobox 2	Mus musculus	0-8
19584092-9	2009	In line with this, Siva1 was lysine-48-linked polyubiquitylated by XIAP.	Lysine	29-35	SIVA1 apoptosis inducing factor	Homo sapiens	19-24
19584092-9	2009	In line with this, Siva1 was lysine-48-linked polyubiquitylated by XIAP.	Lysine	29-35	X-linked inhibitor of apoptosis	Homo sapiens	67-71
19662160-6	2009	We also observed a defect in Cdc14 release in cells lacking H3 lysine 36 methylation (meH3K36) and in cells lacking an HDAC recruited by this modification.	Lysine	63-69	cell division cycle 14A	Homo sapiens	29-34
19500310-1	2009	Human leukocyte antigen (HLA)-DRB1*1611 has one nucleotide change at codon 14 (GAG--&gt;AAG) from DRB1*160201, resulting in a coding change from Glu to Lys.	Lysine	152-155	N-methylpurine DNA glycosylase	Homo sapiens	88-91
19491097-0	2009	GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.	Lysine	85-91	lysine acetyltransferase 2A	Homo sapiens	0-4
19617712-4	2009	Here we report that human double minute-2 protein (HDM2), a p53-specific E3 ubiquitin ligase, specifically ubiquitinates HEXIM1 through the lysine residues located within the basic region of HEXIM1.	Lysine	140-146	MDM2 proto-oncogene	Homo sapiens	51-55
19457126-6	2009	This neuroprotection is dependent on the formation of lysine 48 polyubiquitin linkage which is known to target protein degradation via the proteasome.	Lysine	54-60	Ubiquitin-63E	Drosophila melanogaster	64-77
19457126-7	2009	Consistent with our results that we observed in vivo, we found that ubiquitin co-expression in the cell can facilitate cellular protein degradation by the proteasome in a lysine 48 polyubiquitin-dependent manner.	Lysine	171-177	Ubiquitin-63E	Drosophila melanogaster	68-77
19457126-7	2009	Consistent with our results that we observed in vivo, we found that ubiquitin co-expression in the cell can facilitate cellular protein degradation by the proteasome in a lysine 48 polyubiquitin-dependent manner.	Lysine	171-177	Ubiquitin-63E	Drosophila melanogaster	181-194
19137603-3	2009	To characterize helical and unfolded states adopted by water-soluble Aib-containing peptides, the conformational preference of Ac-Ala-Aib-Ala-Lys-Ala-Aib-Lys-Ala-Lys-Ala-Aib-Tyr-NH(2) was determined by CD, NMR and MD simulations as a function of temperature.	Lysine	142-145	ANIB1	Homo sapiens	69-72
19427866-2	2009	We show here that the nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains.	Lysine	47-53	NBR1 autophagy cargo receptor	Homo sapiens	22-26
19503814-5	2009	In order to characterize the nuclear shuttling activity of Atx3, we performed yeast nuclear import assays and found that Atx3 is actively imported into the nucleus, by means of a classical nuclear localizing sequence formed by a cluster of lysine and arginine residues.	Lysine	240-246	ataxin 3	Homo sapiens	59-63
19503814-5	2009	In order to characterize the nuclear shuttling activity of Atx3, we performed yeast nuclear import assays and found that Atx3 is actively imported into the nucleus, by means of a classical nuclear localizing sequence formed by a cluster of lysine and arginine residues.	Lysine	240-246	ataxin 3	Homo sapiens	121-125
19332550-0	2009	Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.	Lysine	99-102	heterogeneous nuclear ribonucleoprotein L	Homo sapiens	0-41
19484123-8	2009	The Lys 154, 164, and 172 residues of the RIG-I CARD domain were critical for efficient REUL-mediated ubiquitination, as well as the ability of RIG-I to induce activation of IFN-beta promoter.	Lysine	4-7	DExD/H-box helicase 58	Homo sapiens	42-47
19484123-8	2009	The Lys 154, 164, and 172 residues of the RIG-I CARD domain were critical for efficient REUL-mediated ubiquitination, as well as the ability of RIG-I to induce activation of IFN-beta promoter.	Lysine	4-7	ring finger protein 135	Homo sapiens	88-92
19484123-8	2009	The Lys 154, 164, and 172 residues of the RIG-I CARD domain were critical for efficient REUL-mediated ubiquitination, as well as the ability of RIG-I to induce activation of IFN-beta promoter.	Lysine	4-7	DExD/H-box helicase 58	Homo sapiens	144-149
19413317-2	2009	Among the compounds thus designed and synthesized, we found that 2k, which contains an ethoxycarbonyl group at the alpha position to the acetamide of acetylated lysine substrate analogue 1, showed potent inhibitory activity in an in vitro assay using recombinant SIRT1, with high selectivity over SIRT2 and SIRT3.	Lysine	161-167	sirtuin 1	Homo sapiens	263-268
19124278-6	2009	Using an internal standard derived from the parent ProGRP after acetylation of the lysine side chain allowed better quantification through variation correction in all sample pretreatment steps, trypsination included.	Lysine	83-89	gastrin releasing peptide	Homo sapiens	51-57
29305779-2	2018	The chemical structure of LW-1 is still elusive, but earlier NMR analyses showed it has a lysine residue in an aromatic ring coupled to a sugar molecule reminiscent of advanced glycation end-products (AGEs).	Lysine	90-96	heat shock transcription factor family, X-linked 1	Homo sapiens	26-30
29377540-3	2018	Here, we identified miR-99a and its target lysine (K)-specific demethylase 6B (KDM6B) gene as novel modulators of osteogenic differentiation of bone mesenchymal stem cells (BMSCs).	Lysine	43-49	microRNA 99a	Homo sapiens	20-27
29377540-3	2018	Here, we identified miR-99a and its target lysine (K)-specific demethylase 6B (KDM6B) gene as novel modulators of osteogenic differentiation of bone mesenchymal stem cells (BMSCs).	Lysine	43-49	lysine demethylase 6B	Homo sapiens	79-84
29549242-5	2018	The APC4 subunit is the major SUMO target in the complex, containing SUMO acceptor lysines at positions 772 and 798.	Lysine	83-90	anaphase promoting complex subunit 4	Homo sapiens	4-8
29564021-7	2018	A decrease of tri-methylated histone H3 lysine 27 (H3K27Me3) in the coding region of p16(INK4a) was observed.	Lysine	40-46	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	89-94
29539416-4	2018	Sumoylation of Prdm16 at lysine 917 by Cbx4 blocks its ubiquitination-mediated degradation, thereby augmenting its stability and thermogenic function.	Lysine	25-31	PR domain containing 16	Mus musculus	15-21
29520069-4	2018	The HDAC9-MALAT1-BRG1 complex binds chromatin and represses contractile protein gene expression in association with gain of histone H3-lysine 27 trimethylation modifications.	Lysine	135-141	histone deacetylase 9	Homo sapiens	4-9
29324974-7	2018	In addition, an ERAP2 variant in which lysine is changed to asparagine (K392N) results in increased trimming activity (165-fold) for hydrophobic peptides and biologically never been detected.	Lysine	39-45	endoplasmic reticulum aminopeptidase 2	Homo sapiens	16-21
19206074-2	2009	To investigate the effect of dimerization of Tat (48-60) analog, [Tat(W): GRKKRRQRRRPWQ-NH(2)], on antimicrobial activity and mechanism of bactericidal action, its dimeric peptides, di-Tat(W)-C and di-Tat(W)-K, were synthesized by a disulfide bond linkage and lysine linkage of monomeric Tat(W), respectively.	Lysine	260-266	Tat	Human immunodeficiency virus 1	45-48
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	integrin beta 1 (fibronectin receptor beta)	Mus musculus	268-282
19553342-4	2009	In addition, we demonstrate that this disruption is largely dependent on both the integrity of a SUMO interaction motif in LANA2 and the lysine 160 from PML.	Lysine	137-143	PML nuclear body scaffold	Homo sapiens	153-156
19329568-6	2009	This effect could be due to the direct role of Opaque2 on either zein transcription, zeins being major storage proteins devoid of lysine, or lysine degradation through the activation of lysine ketoglutarate reductase.	Lysine	130-136	regulatory protein opaque-2	Zea mays	47-54
19329568-6	2009	This effect could be due to the direct role of Opaque2 on either zein transcription, zeins being major storage proteins devoid of lysine, or lysine degradation through the activation of lysine ketoglutarate reductase.	Lysine	141-147	regulatory protein opaque-2	Zea mays	47-54
19570981-6	2009	Furthermore, a crystal structure of the E12V mutant hTCTP, which lacks the guanine nucleotide exchange factor activity, shows that the deficiency appears to be caused by loss of a salt-bridging interaction with Lys-45 of hRheb.	Lysine	211-214	tumor protein, translationally-controlled 1	Homo sapiens	52-57
19329568-7	2009	Moreover, we found that a polymorphism in the Opaque2 coding sequence and several polymorphisms in the CyPPDK1 promoter nonadditively interact to modify both lysine content and the protein-versus-starch balance, thus revealing the role in quantitative variation in plants of epistatic interactions between a transcriptional activator and one of its target genes.	Lysine	158-164	regulatory protein opaque-2	Zea mays	46-53
19482970-3	2009	In leaves, O2 targets exhibit high cytosine methylation levels and transcriptionally silent chromatin, enriched with histones H3 dimethylated at Lys-9 (H3K9me2) and Lys-27 (H3K27me2).	Lysine	145-148	regulatory protein opaque-2	Zea mays	11-13
29482658-2	2018	The USP7-DNMT1 interaction was reported to be mediated by acetylation of lysine residues within the (GK) repeats.	Lysine	73-79	ubiquitin specific peptidase 7	Homo sapiens	4-8
29482658-2	2018	The USP7-DNMT1 interaction was reported to be mediated by acetylation of lysine residues within the (GK) repeats.	Lysine	73-79	DNA methyltransferase 1	Homo sapiens	9-14
19298866-7	2009	Consistent with transcriptional activation, we show that cAMP signaling increases the trimethylation of Lys 4 on histone H3 (H3K4) along the ASAH1 promoter.	Lysine	104-107	N-acylsphingosine amidohydrolase 1	Homo sapiens	141-146
29491442-2	2018	C. elegans JMJD-1.2, a member of the KDM7 family, is a demethylase active towards several lysine residues on Histone 3 (H3), but its contribution in regulating histone methylation in germ cells has not been fully investigated.	Lysine	90-96	JmjC domain-containing protein;Lysine-specific demethylase 7 homolog	Caenorhabditis elegans	11-19
29491442-3	2018	Here, we show that jmjd-1.2 is expressed abundantly in the germline where it controls the level of histone 3 lysine 9, lysine 23 and lysine 27 di-methylation (H3K9/K23/K27me2) both in mitotic and meiotic cells.	Lysine	109-115	JmjC domain-containing protein;Lysine-specific demethylase 7 homolog	Caenorhabditis elegans	19-27
29491442-3	2018	Here, we show that jmjd-1.2 is expressed abundantly in the germline where it controls the level of histone 3 lysine 9, lysine 23 and lysine 27 di-methylation (H3K9/K23/K27me2) both in mitotic and meiotic cells.	Lysine	119-125	JmjC domain-containing protein;Lysine-specific demethylase 7 homolog	Caenorhabditis elegans	19-27
29491442-3	2018	Here, we show that jmjd-1.2 is expressed abundantly in the germline where it controls the level of histone 3 lysine 9, lysine 23 and lysine 27 di-methylation (H3K9/K23/K27me2) both in mitotic and meiotic cells.	Lysine	119-125	JmjC domain-containing protein;Lysine-specific demethylase 7 homolog	Caenorhabditis elegans	19-27
19482970-3	2009	In leaves, O2 targets exhibit high cytosine methylation levels and transcriptionally silent chromatin, enriched with histones H3 dimethylated at Lys-9 (H3K9me2) and Lys-27 (H3K27me2).	Lysine	165-168	regulatory protein opaque-2	Zea mays	11-13
19218244-10	2009	The proteasome inhibitor MG132 reduced CPT-induced Tra2 degradation and TAF1 alternative splicing, and mutation of evolutionarily conserved Tra2 lysine 81, a potential ubiquitin conjugation site, to arginine inhibited CPT-induced Tra2 degradation, supporting a proteasome-dependent alternative splicing mechanism.	Lysine	145-151	transformer 2	Drosophila melanogaster	140-144
19218244-10	2009	The proteasome inhibitor MG132 reduced CPT-induced Tra2 degradation and TAF1 alternative splicing, and mutation of evolutionarily conserved Tra2 lysine 81, a potential ubiquitin conjugation site, to arginine inhibited CPT-induced Tra2 degradation, supporting a proteasome-dependent alternative splicing mechanism.	Lysine	145-151	transformer 2	Drosophila melanogaster	140-144
19138167-3	2009	By using both P-diverse libraries and a library of phosphonate inhibitors, a TTR preference for a lysine residue in P1 was determined, suggesting that TTR might have a dual specificity and that, in addition to apoA-I, other TTR substrates might exist.	Lysine	98-104	transthyretin	Mus musculus	77-80
19138167-3	2009	By using both P-diverse libraries and a library of phosphonate inhibitors, a TTR preference for a lysine residue in P1 was determined, suggesting that TTR might have a dual specificity and that, in addition to apoA-I, other TTR substrates might exist.	Lysine	98-104	transthyretin	Mus musculus	151-154
29440432-7	2018	Surprisingly, we discovered that DTX1 depletion also elevates Notch1 activity mediated by a mutant form of the receptor that lacks lysine residues for ubiquitination, suggesting that DTX1 targets additional factors.	Lysine	131-137	deltex E3 ubiquitin ligase 1	Homo sapiens	33-37
19138167-3	2009	By using both P-diverse libraries and a library of phosphonate inhibitors, a TTR preference for a lysine residue in P1 was determined, suggesting that TTR might have a dual specificity and that, in addition to apoA-I, other TTR substrates might exist.	Lysine	98-104	apolipoprotein A-I	Mus musculus	210-216
19505526-1	2009	In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde and pyruvate, a reaction catalysed by dihydrodipicolinate synthase (DHDPS, E.C.	Lysine	44-54	dihydrodipicolinate synthase	Escherichia coli	161-189
19138167-3	2009	By using both P-diverse libraries and a library of phosphonate inhibitors, a TTR preference for a lysine residue in P1 was determined, suggesting that TTR might have a dual specificity and that, in addition to apoA-I, other TTR substrates might exist.	Lysine	98-104	transthyretin	Mus musculus	151-154
19172261-4	2009	For this, we introduced alanine and lysine mutations in heag1 channels, and recorded currents by two-electrode voltage clamp.	Lysine	36-42	potassium voltage-gated channel subfamily H member 1	Homo sapiens	56-61
29452636-6	2018	Finally, we identify NOD2 signaling and XIAP-dependent ubiquitination sites on RIP2 and show that mutating these lysine residues adversely affects NOD2 pathway signaling.	Lysine	113-119	X-linked inhibitor of apoptosis	Homo sapiens	40-44
29452636-6	2018	Finally, we identify NOD2 signaling and XIAP-dependent ubiquitination sites on RIP2 and show that mutating these lysine residues adversely affects NOD2 pathway signaling.	Lysine	113-119	receptor interacting serine/threonine kinase 2	Homo sapiens	79-83
19505526-1	2009	In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde and pyruvate, a reaction catalysed by dihydrodipicolinate synthase (DHDPS, E.C.	Lysine	44-54	dihydrodipicolinate synthase	Escherichia coli	191-196
19694578-8	2009	The K(d) of 111In-[DTPA(1), Lys(3), Tyr(4)]-BN in GRPR-expressing PC-3 tumor cells was 22.9 +/- 6.81 nM.	Lysine	28-31	proprotein convertase subtilisin/kexin type 1	Homo sapiens	66-70
29220567-0	2018	Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity.	Lysine	56-62	lysine demethylase 6B	Homo sapiens	40-45
19049339-3	2009	Two mutations were found in the VDR gene: a nonsense mutation (R30X) in the DNA-binding domain and a unique 3-bp in-frame deletion in exon 6 that deleted the codon for lysine at amino acid 246 (DeltaK246).	Lysine	168-174	vitamin D receptor	Homo sapiens	32-35
19139279-4	2009	Here, we demonstrate that Mot1 is SUMOylated in vivo and that disrupting the Slx5-Slx8 pathway by mutation of the target lysines in Mot1, by deletion of SLX5 or the ubiquitin E2 UBC4, or by inhibition of the proteosome suppresses mot1-301 mutant phenotypes and increases the stability of the Mot1-301 protein.	Lysine	121-128	DNA-binding ATPase	Saccharomyces cerevisiae S288C	26-30
19139279-4	2009	Here, we demonstrate that Mot1 is SUMOylated in vivo and that disrupting the Slx5-Slx8 pathway by mutation of the target lysines in Mot1, by deletion of SLX5 or the ubiquitin E2 UBC4, or by inhibition of the proteosome suppresses mot1-301 mutant phenotypes and increases the stability of the Mot1-301 protein.	Lysine	121-128	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	77-81
29220567-1	2018	KDM subfamily 6 enzymes KDM6A and KDM6B specifically catalyze demethylation of di- and trimethylated lysine on histone 3 lysine 27 (H3K27me3/2) and play an important role in repression of developmental genes.	Lysine	101-107	lysine demethylase 6B	Homo sapiens	34-39
19139279-4	2009	Here, we demonstrate that Mot1 is SUMOylated in vivo and that disrupting the Slx5-Slx8 pathway by mutation of the target lysines in Mot1, by deletion of SLX5 or the ubiquitin E2 UBC4, or by inhibition of the proteosome suppresses mot1-301 mutant phenotypes and increases the stability of the Mot1-301 protein.	Lysine	121-128	DNA-binding ATPase	Saccharomyces cerevisiae S288C	132-136
19644140-4	2009	Wild-type receptor tyrosine kinases are efficiently targeted for degradation upon activation, in a process that requires Cbl-mediated monoubiquitination of receptor lysines.	Lysine	165-172	Cbl proto-oncogene	Homo sapiens	121-124
19139279-4	2009	Here, we demonstrate that Mot1 is SUMOylated in vivo and that disrupting the Slx5-Slx8 pathway by mutation of the target lysines in Mot1, by deletion of SLX5 or the ubiquitin E2 UBC4, or by inhibition of the proteosome suppresses mot1-301 mutant phenotypes and increases the stability of the Mot1-301 protein.	Lysine	121-128	DNA-binding ATPase	Saccharomyces cerevisiae S288C	132-136
29395786-2	2018	Chromatin association of UHRF1 is controlled via an interplay between its intramolecular interaction and dual recognition of histone H3 trimethylated at lysine 9 (H3K9me3) and hemimethylated DNA.	Lysine	153-159	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	25-30
19671685-6	2009	The transcription factor pattern and the motile phenotype of metastatic 1833 cells were influenced by p65-lysine acetylation and HDAC-dependent epigenetic mechanisms, which positively regulated basal NF-kappaB and HIF-1 activities.	Lysine	106-112	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	102-105
29331452-2	2018	We have previously reported potent LSD1-selective inhibitors (i.e., NCD18, NCD38, and their analogs) consisting of trans-2-phenylcyclopropylamine (PCPA) or trans-2-arylcyclopropylamine (ACPA) and a lysine moiety that could form a gamma-turn structure in the active site of LSD1.	Lysine	198-204	lysine demethylase 1A	Homo sapiens	35-39
29352221-1	2018	METTL20 is a seven-beta-strand methyltransferase that is localised to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) beta subunit (ETFB) at lysines 200 and 203.	Lysine	170-177	electron transfer flavoprotein beta subunit lysine methyltransferase	Mus musculus	0-7
29352221-9	2018	Thus, METTL20 regulates ETF activity and heat production through lysine methylation when beta-oxidation is highly activated.	Lysine	65-71	electron transfer flavoprotein beta subunit lysine methyltransferase	Mus musculus	6-13
19130199-5	2009	An asparagine-to-lysine change was located immediately proximal to a known CD8(+)T cell epitope in NS4B, while a glutamine-to-lysine change was located within a predicted CD8(+)T cell epitope in NS5.	Lysine	17-23	CD8a molecule	Homo sapiens	75-78
19144645-3	2009	Histone H1 isotype 4 (H1.4) represses transcription, and its lysine residue 26 (Lys(26)) was found to be important in this aspect.	Lysine	61-67	H1.4 linker histone, cluster member	Homo sapiens	22-26
19144645-3	2009	Histone H1 isotype 4 (H1.4) represses transcription, and its lysine residue 26 (Lys(26)) was found to be important in this aspect.	Lysine	80-83	H1.4 linker histone, cluster member	Homo sapiens	22-26
29198865-0	2018	Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors.	Lysine	43-49	lysine demethylase 1A	Homo sapiens	62-91
19473979-7	2009	This motif is located within the L16 extension lying C-terminal to the CD domain in ERK3 and ERK4 and a single isoleucine to lysine substitution in FRIEDE totally abrogates binding, activation, and translocation of MK5 by both ERK3 and ERK4.	Lysine	125-131	immunoglobulin kappa variable 3D-15	Homo sapiens	33-36
29198865-1	2018	Lysine-specific demethylase 1 (LSD1) is a flavin-dependent enzyme that removes methyl groups from mono- or dimethylated lysine residues at the fourth position of histone H3.	Lysine	120-126	lysine demethylase 1A	Homo sapiens	0-29
29198865-1	2018	Lysine-specific demethylase 1 (LSD1) is a flavin-dependent enzyme that removes methyl groups from mono- or dimethylated lysine residues at the fourth position of histone H3.	Lysine	120-126	lysine demethylase 1A	Homo sapiens	31-35
29198865-2	2018	We have previously reported several histone H3 peptides containing an LSD1 inactivator motif at Lys-4.	Lysine	96-99	lysine demethylase 1A	Homo sapiens	70-74
19328069-4	2009	The smc3 mutations cluster around and include a highly conserved lysine (K113) close to Smc3"s ATP-binding pocket, which, together with K112, is acetylated by Eco1.	Lysine	65-71	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	4-8
19328069-4	2009	The smc3 mutations cluster around and include a highly conserved lysine (K113) close to Smc3"s ATP-binding pocket, which, together with K112, is acetylated by Eco1.	Lysine	65-71	Eco1p	Saccharomyces cerevisiae S288C	159-163
19328070-0	2009	Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.	Lysine	37-43	ubiquitin interaction motif containing 1	Homo sapiens	90-95
19008189-2	2009	In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymerases seems to require damage-inducible monoubiquitylation (Ub) of PCNA at lysine residue 164 (PCNA-Ub).	Lysine	190-196	proliferating cell nuclear antigen	Mus musculus	182-186
19432880-4	2009	In addition, the Mdmx mutant cooperates with Mdm2 to induce ubiquitination of p53 at C-terminal lysine residues, and the integrity of the C-terminal lysines was partly required for the cooperative inhibition.	Lysine	96-102	MDM4 regulator of p53	Homo sapiens	17-21
19117940-2	2009	Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta.	Lysine	76-82	membrane associated ring-CH-type finger 8	Homo sapiens	28-38
19386599-1	2009	Thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits anti-fibrinolytic activity by removing C-terminal lysine residues from fibrin or plasminogen receptor proteins on the cellular surface, and plays an important role in the regulation of fibrinolysis.	Lysine	110-116	carboxypeptidase B2	Rattus norvegicus	0-43
19178182-7	2009	Those amino acid side chains involved in binding the dTDP-sugar into the active site include Tyr 183, His 309, and Tyr 310 from subunit 1 and Lys 219 from subunit 2.	Lysine	142-145	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	53-57
29379441-7	2017	The altered lysine degradation, sphingolipid metabolism, glycerophospholipid metabolism, fatty acid metabolism, and bile acid metabolism could be at least partly responsible for the PBR toxic responses in healthy rats.	Lysine	12-18	translocator protein	Rattus norvegicus	182-185
19386599-1	2009	Thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits anti-fibrinolytic activity by removing C-terminal lysine residues from fibrin or plasminogen receptor proteins on the cellular surface, and plays an important role in the regulation of fibrinolysis.	Lysine	110-116	carboxypeptidase B2	Rattus norvegicus	45-49
19498162-5	2009	Select lysine residues in HIF-2alpha that are acetylated during hypoxia confer repression of Sirt1 augmentation by small-molecule inhibitors.	Lysine	7-13	endothelial PAS domain protein 1	Mus musculus	26-36
29511684-0	2018	Oncogenic N-Ras Stimulates SRF-Mediated Transactivation via H3 Acetylation at Lysine 9.	Lysine	78-84	NRAS proto-oncogene, GTPase	Homo sapiens	10-15
29511684-0	2018	Oncogenic N-Ras Stimulates SRF-Mediated Transactivation via H3 Acetylation at Lysine 9.	Lysine	78-84	serum response factor	Homo sapiens	27-30
19199575-0	2009	pH dependence of a mammalian polyamine oxidase: insights into substrate specificity and the role of lysine 315.	Lysine	100-106	polyamine oxidase	Homo sapiens	29-46
19201868-8	2009	p53 was processed to three cleavage products of p40, p35, and p13 fragments at Lys(24) and Lys(305).	Lysine	79-82	interleukin 12A	Homo sapiens	53-56
19199576-2	2009	The linker consists of a carboxyl group in one arm and an activated 1,6-self-immolative para-aminobenzyloxycarbonyl spacer together with a cathepsin B cleavable dipeptide Phe-Lys in the other.	Lysine	175-178	cathepsin B	Homo sapiens	139-150
29434098-1	2018	Previously, we reported that epsilon-poly-L-lysine (25 - 35 residues) significantly promoted a glucose oxidase enzymatic (GOx) reaction using ferricyanide ion as the oxidant, and that the effect was due to the formation of a polyion complex between anionic GOx and protonated (polycationic) epsilon-poly-L-lysine.	Lysine	37-50	hydroxyacid oxidase 1	Homo sapiens	95-120
19498162-5	2009	Select lysine residues in HIF-2alpha that are acetylated during hypoxia confer repression of Sirt1 augmentation by small-molecule inhibitors.	Lysine	7-13	sirtuin 1	Mus musculus	93-98
29434098-1	2018	Previously, we reported that epsilon-poly-L-lysine (25 - 35 residues) significantly promoted a glucose oxidase enzymatic (GOx) reaction using ferricyanide ion as the oxidant, and that the effect was due to the formation of a polyion complex between anionic GOx and protonated (polycationic) epsilon-poly-L-lysine.	Lysine	37-50	hydroxyacid oxidase 1	Homo sapiens	122-125
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	telomerase reverse transcriptase	Homo sapiens	184-189
29434098-1	2018	Previously, we reported that epsilon-poly-L-lysine (25 - 35 residues) significantly promoted a glucose oxidase enzymatic (GOx) reaction using ferricyanide ion as the oxidant, and that the effect was due to the formation of a polyion complex between anionic GOx and protonated (polycationic) epsilon-poly-L-lysine.	Lysine	37-50	hydroxyacid oxidase 1	Homo sapiens	257-260
19061897-0	2009	Identification of lysines within membrane-anchored Mga2p120 that are targets of Rsp5p ubiquitination and mediate mobilization of tethered Mga2p90.	Lysine	18-25	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	80-85
19061897-4	2009	We have identified, using mass spectrometry analysis of in vitro ubiquitinated Mga2p120-Mga2p90 complex, that lysine residues 983 and 985 contained within the carboxy-terminal domain of Mga2p120 are Rsp5p-directed Ub-conjugation sites.	Lysine	110-116	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	199-204
29160738-10	2018	In non-replicated DNA, saturating levels of the 53BP1 binding site, di-methylated lysine 20 of histone 4 (H4K20me2), lead to robust 53BP1-RIF1-MAD2L2 recruitment at DSBs, with consequent exclusion of BRCA1.	Lysine	82-88	BRCA1 DNA repair associated	Homo sapiens	200-205
19332543-5	2009	Substrate specificity of SlSBT3 was analyzed in detail, revealing a preference for Gln and Lys in the P(1) and P(2) positions of oligopeptide substrates, respectively.	Lysine	91-94	subtilisin-like protease	Solanum lycopersicum	25-31
29590644-0	2018	Acetylation of GATA4 on Lysine Residue K313 Promotes Osteoblastic Cells Growth.	Lysine	24-30	GATA binding protein 4	Homo sapiens	15-20
29590644-8	2018	GATA4 can be acetylated by P300/CBP, and the acetylation site was on lysine residue K313.	Lysine	69-75	GATA binding protein 4	Homo sapiens	0-5
19150425-6	2009	Phosphorylation also determines K63-linked polyubiquitination of TRAF2 at lysine 31.	Lysine	74-80	TNF receptor associated factor 2	Homo sapiens	65-70
19240037-6	2009	A homology model of the NR2A(ATD) predicts that Lys(317) is near the surface of the protein and is accessible to plasmin.	Lysine	48-51	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	24-28
19240037-7	2009	Recombinant expression of NR2A with an amino-terminal deletion at Lys(317) is functional and Zn(2+) insensitive.	Lysine	66-69	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	26-30
19475480-4	2009	Infection with viruses containing a lysine at NP 184 induced earlier mortality in chickens, increased virus titers and nitric oxide levels in tissues, and resulted in up-regulated host immune genes, such as alpha-interferon (IFN-alpha), gamma-interferon (IFN-gamma), orthomyxovirus resistance gene 1 (Mx1), and inducible nitric oxide synthase (iNOS).	Lysine	36-42	interferon	Gallus gallus	225-234
19475480-4	2009	Infection with viruses containing a lysine at NP 184 induced earlier mortality in chickens, increased virus titers and nitric oxide levels in tissues, and resulted in up-regulated host immune genes, such as alpha-interferon (IFN-alpha), gamma-interferon (IFN-gamma), orthomyxovirus resistance gene 1 (Mx1), and inducible nitric oxide synthase (iNOS).	Lysine	36-42	interferon	Gallus gallus	255-264
29927684-9	2018	In addition, fluorescence-stained macrophages exhibited a significant decrease in global monomethyl histone 3 lysine 4 (H3K4me) levels following an Aa-LPS challenge that was prevented by KDM4B inhibition, suggesting this effect is produced through KDM1A-mediated demethylation of H3K4.	Lysine	110-116	lysine (K)-specific demethylase 4B	Mus musculus	187-192
19240037-9	2009	Mutating the plasmin cleavage site Lys(317) on NR2A to alanine blocks the effect of plasmin on Zn(2+) inhibition.	Lysine	35-38	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	47-51
19125815-4	2009	In the present study, we investigated the effects of SUMO modification at five lysine residues of LRH-1 in rat granulosa cells.	Lysine	79-85	nuclear receptor subfamily 5, group A, member 2	Rattus norvegicus	98-103
19125815-5	2009	Lysine 289 could be conjugated with SUMO-1 in vitro, and the mutation K289R increased transcriptional activity of LRH-1, suggesting that SUMO conjugation is associated with transcription repression.	Lysine	0-6	small ubiquitin-like modifier 1	Rattus norvegicus	36-42
19281183-6	2009	Cc3125 was shown to catalyze the hydrolysis of l-Xaa-l-Arg/Lys dipeptides but will not hydrolyze tripeptides or the N-formyl and N-acetyl derivatives of lysine or arginine.	Lysine	59-62	amidohydrolase family protein	Caulobacter vibrioides CB15	0-6
19125815-5	2009	Lysine 289 could be conjugated with SUMO-1 in vitro, and the mutation K289R increased transcriptional activity of LRH-1, suggesting that SUMO conjugation is associated with transcription repression.	Lysine	0-6	nuclear receptor subfamily 5, group A, member 2	Rattus norvegicus	114-119
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	43-49	myelin basic protein	Rattus norvegicus	102-122
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	43-49	myelin basic protein	Rattus norvegicus	124-127
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	56-62	myelin basic protein	Rattus norvegicus	102-122
18627006-4	2009	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Lysine	56-62	myelin basic protein	Rattus norvegicus	124-127
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	31-34	carboxypeptidase E	Mus musculus	8-11
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	31-34	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	31-34	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	309-312	carboxypeptidase E	Mus musculus	8-11
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	309-312	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Lysine	309-312	carboxypeptidase E	Mus musculus	109-112
19117199-10	2009	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of a conformation-specific epitope of hCGbeta consists of Arg (94, 95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Lysine	249-252	chorionic gonadotropin subunit beta 3	Homo sapiens	195-202
19208907-0	2009	Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.	Lysine	160-166	methyl-CpG binding domain protein 2	Homo sapiens	71-82
19247601-6	2009	We describe the determination of these cross-links in detail.Elastin is also stabilised by cross-linking based on oxidative deamination of most of its lysine residues to yield tetravalent cross-links, desmosine and iso-desmosine, the determination of which is also described.A second cross-linking pathway occurs during ageing (and to a greater extent in diabetes mellitus) involving reaction with tissue glucose.	Lysine	151-157	elastin	Homo sapiens	61-68
29211711-7	2017	KAT2A acts as a succinyltransferase and succinylates histone H3 on lysine 79, with a maximum frequency around the transcription start sites of genes.	Lysine	67-73	lysine acetyltransferase 2A	Homo sapiens	0-5
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	Meis homeobox 1	Homo sapiens	319-324
19373254-7	2009	We found that the UBAN (ubiquitin binding in ABIN and NEMO) motif of NEMO (NF-kappaB essential modifier) binds to linear chains exclusively, whereas the NZF (Npl4 zinc finger) domain of TAB2 (TAK1 binding protein 2) is Lys 63 specific.	Lysine	219-222	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	69-73
29061647-1	2017	Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5"-phosphate (vitamin B6 vitamers).	Lysine	88-94	aldehyde dehydrogenase 7 family, member A1	Danio rerio	112-119
29061647-3	2017	Over 60 years after the initial description of PDE, we report the first animal model for this disease: an aldh7a1-null zebrafish (Danio rerio) displaying deficient lysine metabolism and spontaneous and recurrent seizures in the larval stage (10 days postfertilization).	Lysine	164-170	aldehyde dehydrogenase 7 family, member A1	Danio rerio	106-113
29061647-8	2017	Impaired lysine degradation with accumulation of PDE biomarkers, B6 deficiency, and low gamma-aminobutyric acid levels were observed in the aldh7a1-/- larvae, which may play a significant role in the seizure phenotype and PDE pathogenesis.	Lysine	9-15	aldehyde dehydrogenase 7 family, member A1	Danio rerio	140-147
18987336-5	2009	The key ubiquitination sites Lys-19 and Lys-49 of beta-catenin were shown as the critical residues for PCAF-induced acetylation and stabilization.	Lysine	29-32	catenin (cadherin associated protein), beta 1	Mus musculus	50-62
18987336-5	2009	The key ubiquitination sites Lys-19 and Lys-49 of beta-catenin were shown as the critical residues for PCAF-induced acetylation and stabilization.	Lysine	40-43	catenin (cadherin associated protein), beta 1	Mus musculus	50-62
19440361-8	2009	UBDs favored the monoubiquitination of USP25m at the preferential site lysine 99 (K99).	Lysine	71-77	ubiquitin specific peptidase 25	Homo sapiens	39-44
19440361-10	2009	We showed that mutation of K99 clearly diminished USP25-dependent rescue of the specific substrate MyBPC1 from proteasome degradation, thereby supporting a new mechanistic model, in which USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains.	Lysine	299-305	ubiquitin specific peptidase 25	Homo sapiens	50-55
19373254-7	2009	We found that the UBAN (ubiquitin binding in ABIN and NEMO) motif of NEMO (NF-kappaB essential modifier) binds to linear chains exclusively, whereas the NZF (Npl4 zinc finger) domain of TAB2 (TAK1 binding protein 2) is Lys 63 specific.	Lysine	219-222	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	75-103
19440361-10	2009	We showed that mutation of K99 clearly diminished USP25-dependent rescue of the specific substrate MyBPC1 from proteasome degradation, thereby supporting a new mechanistic model, in which USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains.	Lysine	299-305	ubiquitin specific peptidase 25	Homo sapiens	188-193
19368801-1	2009	Suppressor-of-zeste-12 (Su(z)12) is a core component of the Polycomb repressive complex 2 (PRC2), which has a methyltransferase activity directed towards lysine residues of histone 3.	Lysine	154-160	Su(z)12	Drosophila melanogaster	0-22
19689412-2	2009	Among these, the most frequent type presents a lysine residue at position 49 (Lys49), in substitution of the otherwise conserved aspartate (Asp49) of catalytically-active PLA(2)s.	Lysine	47-53	phospholipase A2 group IIA	Homo sapiens	171-178
28663172-7	2017	Proteomic analysis by SILAC revealed specific upregulation of large ribosomal subunit proteins in the METTL21B knockout, and changes to further processes related to eEF1A function in knockouts of both METTL21B and EEF1AKMT1 This indicates that the methylation of lysine 165 in human eEF1A has a very specific role.	Lysine	263-269	EEF1A lysine methyltransferase 1	Homo sapiens	214-223
19368801-1	2009	Suppressor-of-zeste-12 (Su(z)12) is a core component of the Polycomb repressive complex 2 (PRC2), which has a methyltransferase activity directed towards lysine residues of histone 3.	Lysine	154-160	Su(z)12	Drosophila melanogaster	24-31
19140836-2	2009	The novel B*4076 is identical to B*400101 with an exception of one base substitution at position 239(C&gt;A)of exon 2 resulting in codon #80 changed from AAC (Asn) to AAA (Lys).	Lysine	172-175	glycine-N-acyltransferase	Homo sapiens	154-157
19255242-6	2009	Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.	Lysine	110-116	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	98-101
29184203-5	2017	Furthermore, we found that Arid1b haploinsufficiency suppressed histone H3 lysine 9 acetylation (H3K9ac) overall and particularly reduced H3K9ac of the Pvalb promoter, resulting in decreased transcription.	Lysine	75-81	AT rich interactive domain 1B (SWI-like)	Mus musculus	27-33
29183317-4	2017	RESULTS: In the hippocampus, Smad4 is SUMOylated by the E3 ligase PIAS1 at Lys-113 and Lys-159.	Lysine	75-78	protein inhibitor of activated STAT, 1	Rattus norvegicus	66-71
19111657-4	2008	Furthermore, addition of the FANCI protein enhances monoubiquitination and also restricts it to the in vivo substrate lysine residue on FANCD2.	Lysine	118-124	FA complementation group D2	Homo sapiens	136-142
19255242-6	2009	Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.	Lysine	110-116	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	102-106
28977641-7	2017	When PP32 and SET/TAF-Ibeta protein levels are down-regulated in vivo, we detect hyperacetylation on lysines 5 and 12 and other H4 lysine residues.	Lysine	101-107	SET nuclear proto-oncogene	Homo sapiens	18-27
19255242-6	2009	Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.	Lysine	110-116	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	178-181
19255242-6	2009	Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes.	Lysine	110-116	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	182-186
19012067-8	2008	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of hCGbeta epitope consists of Arg (94,95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Lysine	221-224	chorionic gonadotropin subunit beta 3	Homo sapiens	160-167
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	Lysine	182-188	aminoadipate aminotransferase	Homo sapiens	0-35
29021135-5	2017	Mechanistic investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate PIK3CA transcription, thereby enhancing PI3K/AKT signaling and tumorigenesis.	Lysine	62-68	tripartite motif containing 24	Homo sapiens	147-153
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	Lysine	182-188	aminoadipate aminotransferase	Homo sapiens	37-43
18815279-6	2008	A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues.	Lysine	38-45	nuclear transcription factor Y subunit alpha	Homo sapiens	2-7
18815279-6	2008	A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues.	Lysine	133-140	nuclear transcription factor Y subunit alpha	Homo sapiens	2-7
18815279-6	2008	A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues.	Lysine	133-140	nuclear transcription factor Y subunit alpha	Homo sapiens	2-7
18829459-1	2008	The mixed lineage leukemia protein-1 (MLL1) catalyzes histone H3 lysine 4 methylation and is regulated by interaction with WDR5 (WD-repeat protein-5), RbBP5 (retinoblastoma-binding protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.	Lysine	65-71	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	201-206
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	Lysine	182-188	aminoadipate aminotransferase	Homo sapiens	69-99
18831049-1	2009	Alpha-aminoadipate aminotransferase (AAA-AT), a homolog of mammalian kynurenine aminotransferase II (Kat II), transfers an amino group to 2-oxoadipate to yield alpha-aminoadipate in lysine biosynthesis through the alpha-aminoadipate pathway in Thermus thermophilus.	Lysine	182-188	aminoadipate aminotransferase	Homo sapiens	101-107
18818090-2	2008	The association of Rpd3S with chromatin requires its Eaf3 subunit, which binds histone H3 methylated at lysine 36 (H3K36).	Lysine	104-110	Eaf3p	Saccharomyces cerevisiae S288C	53-57
19405949-9	2009	CONCLUSION: Our studies demonstrate that PP2A interacts with the cytoplasmic tail of human CTLA-4 through two motifs, the lysine rich motif centered at lysine 155 and the tyrosine residue 182.	Lysine	122-128	protein phosphatase 2 phosphatase activator	Homo sapiens	41-45
29045138-1	2017	Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	Lysine	68-74	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-26
19405949-9	2009	CONCLUSION: Our studies demonstrate that PP2A interacts with the cytoplasmic tail of human CTLA-4 through two motifs, the lysine rich motif centered at lysine 155 and the tyrosine residue 182.	Lysine	122-128	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	91-97
29045138-1	2017	Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate.	Lysine	68-74	aldehyde dehydrogenase 7 family member A1	Homo sapiens	28-35
19405949-9	2009	CONCLUSION: Our studies demonstrate that PP2A interacts with the cytoplasmic tail of human CTLA-4 through two motifs, the lysine rich motif centered at lysine 155 and the tyrosine residue 182.	Lysine	152-158	protein phosphatase 2 phosphatase activator	Homo sapiens	41-45
18775985-2	2008	Results obtained led us to conclude that photoactivation of this probe in complex with hMMP-12 affects a single residue in human MMP-12, Lys(241), through covalent modification of its side chain epsilon NH(2) group.	Lysine	137-140	matrix metallopeptidase 12	Homo sapiens	87-94
18775985-2	2008	Results obtained led us to conclude that photoactivation of this probe in complex with hMMP-12 affects a single residue in human MMP-12, Lys(241), through covalent modification of its side chain epsilon NH(2) group.	Lysine	137-140	matrix metallopeptidase 12	Homo sapiens	88-94
19405949-9	2009	CONCLUSION: Our studies demonstrate that PP2A interacts with the cytoplasmic tail of human CTLA-4 through two motifs, the lysine rich motif centered at lysine 155 and the tyrosine residue 182.	Lysine	152-158	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	91-97
18775985-3	2008	Because x-ray and NMR studies of hMMP-12 indicate that Lys(241) side chain is highly flexible, our data reveal the existence of particular Lys(241) side-chain conformation in which the epsilon NH(2) group points toward the photolabile group of the probe, an event explaining the high levels of cross-linking yield between hMMP-12 and the probe.	Lysine	55-58	matrix metallopeptidase 12	Homo sapiens	33-40
18775985-3	2008	Because x-ray and NMR studies of hMMP-12 indicate that Lys(241) side chain is highly flexible, our data reveal the existence of particular Lys(241) side-chain conformation in which the epsilon NH(2) group points toward the photolabile group of the probe, an event explaining the high levels of cross-linking yield between hMMP-12 and the probe.	Lysine	139-142	matrix metallopeptidase 12	Homo sapiens	33-40
28893905-0	2017	Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells.	Lysine	0-6	sirtuin 1	Homo sapiens	86-95
19262565-0	2009	Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.	Lysine	57-63	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	43-47
28992316-1	2017	Chromobox 2 (CBX2), a component of polycomb repressive complex 1 (PRC1), binds lysine 27-methylated histone H3 (H3K27me3) via its chromodomain (CD) and plays a critical role in repressing developmentally regulated genes.	Lysine	79-85	chromobox 2	Homo sapiens	0-11
18775985-3	2008	Because x-ray and NMR studies of hMMP-12 indicate that Lys(241) side chain is highly flexible, our data reveal the existence of particular Lys(241) side-chain conformation in which the epsilon NH(2) group points toward the photolabile group of the probe, an event explaining the high levels of cross-linking yield between hMMP-12 and the probe.	Lysine	139-142	matrix metallopeptidase 12	Homo sapiens	322-329
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	85-88	E1A binding protein p300	Mus musculus	77-81
28992316-1	2017	Chromobox 2 (CBX2), a component of polycomb repressive complex 1 (PRC1), binds lysine 27-methylated histone H3 (H3K27me3) via its chromodomain (CD) and plays a critical role in repressing developmentally regulated genes.	Lysine	79-85	chromobox 2	Homo sapiens	13-17
19262565-5	2009	Mutational and mass spectrometric analyses reveal that RelA is monomethylated by Set9 at lysine residues 314 and 315 in vitro and in vivo.	Lysine	89-95	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	81-85
18995839-5	2008	In contrast, upon DSK2 induction, conjugates accumulated primarily in the form of lysine 48 linkages correlating with impaired proteolysis and cytotoxicity.	Lysine	82-88	ubiquitin domain-containing protein DSK2	Saccharomyces cerevisiae S288C	18-22
19299466-3	2009	Here, we show that RECQL4 specifically interacts with the histone acetyltransferase p300 (also known as p300 HAT), both in vivo and in vitro, and that p300 acetylates one or more of the lysine residues at positions 376, 380, 382, 385 and 386 of RECQL4.	Lysine	186-192	RecQ like helicase 4	Homo sapiens	19-25
19506739-3	2008	Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin.	Lysine	181-187	trithorax	Drosophila melanogaster	131-140
28820351-3	2017	We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation of H3 lysine 4, consistent with coordinated formation and action of both PRDM9-dependent histone modifications.	Lysine	42-48	PR domain containing 9	Mus musculus	222-227
28820351-3	2017	We find that trimethylation of histone H3 lysine 36 around DSB hotspots is highly correlated, both spatially and quantitatively, with trimethylation of H3 lysine 4, consistent with coordinated formation and action of both PRDM9-dependent histone modifications.	Lysine	155-161	PR domain containing 9	Mus musculus	222-227
19299466-4	2009	Furthermore, we report that these five lysine residues lie within a short motif of 30 amino acids that is essential for the nuclear localization of RECQL4.	Lysine	39-45	RecQ like helicase 4	Homo sapiens	148-154
19436139-0	2009	Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes.	Lysine	31-37	adiponectin, C1Q and collagen domain containing	Mus musculus	47-58
18722556-2	2008	Error-prone replication involves translesion polymerases and requires monoubiquitylation at lysine (K) 164 of PCNA by the Rad6 and Rad18 enzymes.	Lysine	92-98	RAD18 E3 ubiquitin protein ligase	Homo sapiens	131-136
18767117-4	2008	Surprisingly, Lys, His, and Thr inhibited S6K1 phosphorylation in both murine and bovine mammary cells.	Lysine	14-17	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	42-46
19436139-2	2009	In this study, we found that all methylations (mono-, di-, tri-) of histone H3 at lysine 9 on the adiponectin gene decreased by stimulating adipocyte differentiation prior to increases in adiponectin gene expression and acetylation of histone H3 at the same residue on the gene during adipocyte differentiation of 3T3-L1 cells.	Lysine	82-88	adiponectin, C1Q and collagen domain containing	Mus musculus	98-109
18799617-0	2008	HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.	Lysine	37-43	NAD-dependent histone deacetylase HST4	Saccharomyces cerevisiae S288C	5-9
29042477-0	2017	KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis.	Lysine	43-49	lysine (K)-specific demethylase 3A L homeolog	Xenopus laevis	0-5
19436139-2	2009	In this study, we found that all methylations (mono-, di-, tri-) of histone H3 at lysine 9 on the adiponectin gene decreased by stimulating adipocyte differentiation prior to increases in adiponectin gene expression and acetylation of histone H3 at the same residue on the gene during adipocyte differentiation of 3T3-L1 cells.	Lysine	82-88	adiponectin, C1Q and collagen domain containing	Mus musculus	188-199
19436139-3	2009	Additionally, we revealed that decrease of adiponectin gene expression by treatment with TNFalpha, an inducer of insulin resistance in adipocytes, was associated with decreased acetylation of histone H3 at lysine 9 on the gene, but not methylations.	Lysine	206-212	adiponectin, C1Q and collagen domain containing	Mus musculus	43-54
19436139-4	2009	Our results suggest that induction of the adiponectin gene during adipocyte differentiation is associated with modification of histone H3 at lysine 9 from methylations to acetylation, whereas reduction of the adiponectin gene in 3T3-L1 adipocytes with insulin resistance is associated with decreased acetylation at lysine 9 of histone H3.	Lysine	141-147	adiponectin, C1Q and collagen domain containing	Mus musculus	42-53
18706911-6	2008	We proposed a reaction mechanism for BisANS with nucleophilic amino acids such as lysine, serine, threonine, and tyrosine, and BisANS was found to be primarily incorporated to lysine residues in GAPDH.	Lysine	176-182	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	195-200
28741798-6	2017	EZH1/2 dual inhibitors suppressed trimethylation of histone H3 lysine 27 in cells more than EZH2 selective inhibitors.	Lysine	63-69	enhancer of zeste 1 polycomb repressive complex 2 subunit	Rattus norvegicus	0-4
19436139-4	2009	Our results suggest that induction of the adiponectin gene during adipocyte differentiation is associated with modification of histone H3 at lysine 9 from methylations to acetylation, whereas reduction of the adiponectin gene in 3T3-L1 adipocytes with insulin resistance is associated with decreased acetylation at lysine 9 of histone H3.	Lysine	315-321	adiponectin, C1Q and collagen domain containing	Mus musculus	42-53
18687677-5	2008	In the 293T cells, SIRT1 overexpression diminished lysine acetylation of LKB1 and concurrently increased its activity, cytoplasmic/nuclear ratio, and association with the LKB1 activator STRAD.	Lysine	51-57	sirtuin 1	Homo sapiens	19-24
19122196-4	2009	The loss of co-repressor NCoR1-histone deacetylase (HDAC) 3 complex and inhibitory chromatin looping from VDREs to the TSS are also initial events followed by increased acetylation of histone 3 at lysine 9 at the TSS prior to initiation of transcription.	Lysine	197-203	nuclear receptor corepressor 1	Homo sapiens	25-30
18707894-0	2008	Structural insights into histone H3 lysine 56 acetylation by Rtt109.	Lysine	36-42	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	61-67
18707894-2	2008	Saccharomyces cerevisiae Rtt109 is an important class of histone acetyltransferases (HATs), which promote genome stability by directly acetylating newly synthesized histone H3 lysine 56 (H3-K56) through an unknown mechanism.	Lysine	176-182	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	25-31
28508686-3	2017	Recurrent inactivation of EED or SUZ12 in a majority of MPNSTs results in a complete loss of trimethylated histone H3 at lysine 27 (H3K27me3) immunoreactivity, making it a highly specific biomarker of MPNSTs.	Lysine	121-127	embryonic ectoderm development	Homo sapiens	26-29
28771755-8	2017	Furthermore, PKL affects the level of trimethylation of histone H3 Lys 27 associated with INDOLE-3-ACETIC ACID INDUCIBLE 19 (IAA19) and IAA29 and regulates their expression.	Lysine	67-70	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	13-16
19261746-4	2009	Moreover, MERIT40 is required for Rap80-associated lysine(63)-ubiquitin DUB activity, a critical component of BRCA1-Rap80 G2 checkpoint and viability responses to ionizing radiation.	Lysine	51-57	BRISC and BRCA1 A complex member 1	Homo sapiens	10-17
28782268-3	2017	BMP7 promoter activation occurred through the corecruitment of HOXA13, mixed-lineage leukemia 1 lysine N-methyltransferase, WD repeat-containing protein 5, and lncRNA HoxA transcript at the distal tip (HOTTIP) to commit the epigenetic changes to the trimethylation of lysine 4 on histone H3 in cancer cells.	Lysine	96-102	bone morphogenetic protein 7	Homo sapiens	0-4
18644859-6	2008	Interestingly, mutation of the sumoylation site (Lys(259)) of BMAL1 markedly inhibited both its ubiquitination and its proteasome-mediated proteolysis, and these effects were reversed by covalent attachment of SUMO3 to the C terminus of the mutant BMAL1.	Lysine	49-52	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	62-67
18644859-6	2008	Interestingly, mutation of the sumoylation site (Lys(259)) of BMAL1 markedly inhibited both its ubiquitination and its proteasome-mediated proteolysis, and these effects were reversed by covalent attachment of SUMO3 to the C terminus of the mutant BMAL1.	Lysine	49-52	small ubiquitin like modifier 3	Homo sapiens	210-215
18644859-6	2008	Interestingly, mutation of the sumoylation site (Lys(259)) of BMAL1 markedly inhibited both its ubiquitination and its proteasome-mediated proteolysis, and these effects were reversed by covalent attachment of SUMO3 to the C terminus of the mutant BMAL1.	Lysine	49-52	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	248-253
18710948-0	2008	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.	Lysine	31-37	PDZ and LIM domain 7	Homo sapiens	160-185
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	20-26	lysine (K)-specific demethylase 4A	Mus musculus	0-5
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	20-26	lysine (K)-specific demethylase 4A	Mus musculus	7-13
18599482-4	2008	Ataxin-3 binds both Lys(48)- or Lys(63)-linked chains yet preferentially cleaves Lys(63) linkages.	Lysine	20-23	ataxin 3	Homo sapiens	0-8
19040354-10	2009	Finally, we observed that a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination, also suggesting that posttranslational modifications can affect substrate efficiency.	Lysine	39-45	peptidyl arginine deiminase 4	Homo sapiens	96-101
18599482-4	2008	Ataxin-3 binds both Lys(48)- or Lys(63)-linked chains yet preferentially cleaves Lys(63) linkages.	Lysine	32-35	ataxin 3	Homo sapiens	0-8
18599482-4	2008	Ataxin-3 binds both Lys(48)- or Lys(63)-linked chains yet preferentially cleaves Lys(63) linkages.	Lysine	32-35	ataxin 3	Homo sapiens	0-8
18758443-6	2008	The core and Ins-1 form a catalytic groove that accommodates the Lys 63 side chain of the proximal ubiquitin and the isopeptide-linked carboxy-terminal tail of the distal ubiquitin.	Lysine	65-68	forkhead box M1	Homo sapiens	13-18
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	87-93	lysine (K)-specific demethylase 4A	Mus musculus	0-5
28827393-2	2017	KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3).	Lysine	87-93	lysine (K)-specific demethylase 4A	Mus musculus	7-13
28798096-3	2017	Using a multiwell in vitro assay, S100P is now shown for the first time to exhibit a strong, C-terminal lysine-dependent activation of tissue plasminogen activator (tPA), but not of urokinase-catalysed plasminogen activation.	Lysine	104-110	chromosome 20 open reading frame 181	Homo sapiens	135-163
28798096-9	2017	The protease inhibitors, aprotinin or alpha-2-antiplasmin, reduced the invasion of S100P-expressing cells, but not of S100P-negative control cells, nor cells expressing S100P protein lacking the C-terminal lysine.	Lysine	206-212	serpin family F member 2	Homo sapiens	38-57
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	124-127	inhibitor of growth family member 1	Homo sapiens	50-53
28720390-1	2017	The Lysine-specific demethylase 1, KDM1A/LSD1, plays a central role in the regulation of Pol II transcription through the removal of the activation mark (mono- and dimethyl lysine 4 of histone H3).	Lysine	173-179	lysine demethylase 1A	Homo sapiens	35-40
28720390-1	2017	The Lysine-specific demethylase 1, KDM1A/LSD1, plays a central role in the regulation of Pol II transcription through the removal of the activation mark (mono- and dimethyl lysine 4 of histone H3).	Lysine	173-179	lysine demethylase 1A	Homo sapiens	41-45
18501205-7	2008	Mutagenesis data supports the notion that Thr-236 regulates this process since mutating Thr-236 to Ala-236 increased basal and LPA-mediated serum response factor (SRF) signaling activity and Lys-236 further increased this basal signaling.	Lysine	191-194	serum response factor	Homo sapiens	140-161
19085961-8	2009	Moreover, we found that ectopic overexpression of p33(ING1b) or p24(ING1c) significantly induced p53 protein acetylation at Lys-373/Lys-382 residue, but did not alter the phosphorylation status of p53.	Lysine	132-135	inhibitor of growth family member 1	Homo sapiens	50-53
19029092-4	2009	Mutation of a single site in MafA, Lys(32), blocks its sumoylation in beta cells.	Lysine	35-38	MAF bZIP transcription factor A	Homo sapiens	29-33
18620416-2	2008	Tetrapeptide H-[Ile-Ser-Lys(Ox)]-OH, containing a turn-inducing oxazole constraint, was connected through its lysine side chain via a beta-alanine linker to the C-terminus of a two-turn helical nonapeptide Ac-(cyclo-4,8)-LRL [KARAD](Aib).	Lysine	110-116	ANIB1	Homo sapiens	233-236
18716661-0	2008	The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment.	Lysine	15-21	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	46-51
28525871-5	2017	The ionized groups of PFCs can form electrostatic interactions with the -NH+3 groups of Lys 15 residues in hTTR and form hydrogen bonds with the residues of hTTR.	Lysine	88-91	transthyretin	Homo sapiens	107-111
19227476-4	2009	Covalent attachment of folate to the lysine side chain amino groups was used to reroute the LDL from its natural receptor (LDLR) to folate receptors and could be utilized to target other receptors.	Lysine	37-43	low density lipoprotein receptor	Homo sapiens	123-127
28230279-3	2017	The regulation on CFTR expression was mediated by CFTR promoter methylation and trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	98-104	cystic fibrosis transmembrane conductance regulator	Mus musculus	18-22
18539592-0	2008	The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27.	Lysine	64-70	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	4-8
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Lysine	53-59	serpin family C member 1	Homo sapiens	47-52
18597497-7	2008	Recombinant CBR underwent irreversible inhibition during QM exposure, and mass spectrometry was utilized to identify alkylation sites at Cys 51, Lys 17, Lys 189, Lys 201, His 28, and His 204.	Lysine	145-148	carbonyl reductase 1	Mus musculus	12-15
18597497-7	2008	Recombinant CBR underwent irreversible inhibition during QM exposure, and mass spectrometry was utilized to identify alkylation sites at Cys 51, Lys 17, Lys 189, Lys 201, His 28, and His 204.	Lysine	153-156	carbonyl reductase 1	Mus musculus	12-15
28627122-11	2017	These results suggest that biotinylated peptides, especially BP21, can specifically and markedly inhibit anaphylactic reactions in vivo and that this involves direct interaction of its Tyr-Lys-Asp-Gly region with PAF.	Lysine	189-192	PCNA clamp associated factor	Rattus norvegicus	213-216
28695742-5	2017	Here we identified seven potential SUMO target sites (lysine residues) on Ki-1/57 sequence and observed that Ki-1/57 is modified by SUMO proteins in vitro and in vivo.	Lysine	54-60	TNF receptor superfamily member 8	Homo sapiens	74-78
18597497-7	2008	Recombinant CBR underwent irreversible inhibition during QM exposure, and mass spectrometry was utilized to identify alkylation sites at Cys 51, Lys 17, Lys 189, Lys 201, His 28, and His 204.	Lysine	153-156	carbonyl reductase 1	Mus musculus	12-15
28695742-5	2017	Here we identified seven potential SUMO target sites (lysine residues) on Ki-1/57 sequence and observed that Ki-1/57 is modified by SUMO proteins in vitro and in vivo.	Lysine	54-60	TNF receptor superfamily member 8	Homo sapiens	109-113
28695742-6	2017	We showed that SUMOylation of Ki-1/57 occurred on lysines 213, 276, and 336.	Lysine	50-57	TNF receptor superfamily member 8	Homo sapiens	30-34
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Lysine	53-59	serpin family C member 1	Homo sapiens	107-112
18676811-3	2008	The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that deacetylation of the histone variant Htz1p at Lys 14 is mediated by Hda1p.	Lysine	175-178	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	197-202
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Lysine	53-59	serpin family C member 1	Homo sapiens	107-112
18541663-0	2008	Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.	Lysine	85-91	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	10-14
18541663-1	2008	Set2 (KMT3)-dependent methylation (me) of histone H3 at lysine 36 (H3K36) promotes deacetylation of transcribed chromatin and represses cryptic promoters within genes.	Lysine	56-62	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-4
19661678-2	2009	The C-terminal domain of XPD has been implicated in interactions with other components of the TFIIH complex, and it is also the site of a common genetic polymorphism in XPD at amino acid residue 751 (Lys-&gt;Gln).	Lysine	200-203	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	25-28
18622391-1	2008	Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior monoubiquitination of histone H2B.	Lysine	25-31	histone H2B	Saccharomyces cerevisiae S288C	100-111
19661678-2	2009	The C-terminal domain of XPD has been implicated in interactions with other components of the TFIIH complex, and it is also the site of a common genetic polymorphism in XPD at amino acid residue 751 (Lys-&gt;Gln).	Lysine	200-203	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	169-172
19109177-3	2009	Recent studies have revealed the essential role of Lys(55) in the collagenous region of MBL in the interaction with the MASPs and calreticulin (CRT).	Lysine	51-54	mannose binding lectin 2	Homo sapiens	88-91
28636886-6	2017	Studies with a novel, non-acetylatable VDR mutant (K413R) showed that the mutant VDR possesses enhanced responsiveness to 1,25D, in conjunction with reduced, but still significant, sensitivity to exogenous SIRT1, indicating that acetylation of lysine 413 is relevant, but that other acetylated residues in VDR contribute to modulation of its activity.	Lysine	244-250	vitamin D receptor	Homo sapiens	81-84
28636886-6	2017	Studies with a novel, non-acetylatable VDR mutant (K413R) showed that the mutant VDR possesses enhanced responsiveness to 1,25D, in conjunction with reduced, but still significant, sensitivity to exogenous SIRT1, indicating that acetylation of lysine 413 is relevant, but that other acetylated residues in VDR contribute to modulation of its activity.	Lysine	244-250	vitamin D receptor	Homo sapiens	81-84
19109177-7	2009	In the case of MASP-1 and MASP-3, replacement of the target Lys residues by Ala or Glu abolished interaction, whereas the Lys to Arg mutations had only slight inhibitory effects.	Lysine	60-63	MBL associated serine protease 1	Homo sapiens	15-21
18492669-4	2008	We identify two lysine residues involved in SUMO attachment, one at the C terminus, between the DNA binding and oligomerization domains, and one at the N terminus of the protein.	Lysine	16-22	smt3	Drosophila melanogaster	44-48
19109177-7	2009	In the case of MASP-1 and MASP-3, replacement of the target Lys residues by Ala or Glu abolished interaction, whereas the Lys to Arg mutations had only slight inhibitory effects.	Lysine	60-63	MBL associated serine protease 1	Homo sapiens	26-32
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	24-27	mannose binding lectin 2	Homo sapiens	165-168
18632619-6	2008	Whereas Mdm2 catalyzed lysine 63 (K63) chain ubiquitination, c-Cbl modified IGF-IR through K48 chains.	Lysine	23-29	MDM2 proto-oncogene	Homo sapiens	8-12
28855971-9	2017	Cohesin-bound genes were found to be enriched for histone H3 lysine 4 trimethylation (H3K4me3) at their promoters; were disproportionately downregulated in Nipbl mutant MEFs; and displayed evidence of reduced promoter-enhancer interaction.	Lysine	61-67	NIPBL cohesin loading factor	Mus musculus	156-161
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	49-52	ficolin 3	Homo sapiens	60-69
18632619-9	2008	Taken together, our results show that c-Cbl constitutes a new ligase responsible for the ubiquitination of IGF-IR and that it complements the action of Mdm2 on ubiquitin lysine residue specificity, responsiveness to IGF-I, and type of endocytic pathway used.	Lysine	170-176	MDM2 proto-oncogene	Homo sapiens	152-156
19013523-2	2009	TG2 catalyses the crosslinking of proteins via the formation of highly stable epsilon(gamma-glutamyl) lysine bonds.	Lysine	102-108	transglutaminase 2, C polypeptide	Mus musculus	0-3
18450745-9	2008	The CDY chromodomain exhibits discriminatory binding to lysine-methylated ARK(S/T) motifs, whereas the CDYL2 chromodomain binds with comparable strength to multiple ARK(S/T) motifs.	Lysine	56-62	chromodomain Y like 2	Homo sapiens	103-108
18457658-2	2008	In this study, the lysine selection process for TRAF6/p62 ubiquitination was examined.	Lysine	19-25	nucleoporin 62	Homo sapiens	54-57
18457658-5	2008	Interestingly, Lysine 811 in TrkB was selected for ubiquination, and mutation of Lysine 811 diminished the formation of TRAF6/p62 complex that is necessary for effective ubiquination.	Lysine	15-21	nucleoporin 62	Homo sapiens	126-129
18457658-5	2008	Interestingly, Lysine 811 in TrkB was selected for ubiquination, and mutation of Lysine 811 diminished the formation of TRAF6/p62 complex that is necessary for effective ubiquination.	Lysine	81-87	nucleoporin 62	Homo sapiens	126-129
18457658-7	2008	These findings reveal a possible selection process for targeting a specific lysine residue by a single E3 ligase and underscore the role of the scaffold, p62, in this process.	Lysine	76-82	nucleoporin 62	Homo sapiens	154-157
28810879-3	2017	Moreover, the SPOP mutation sites are distributed in a relatively short region with multiple lysine residues, posing significant challenges for bottom-up proteomics analysis of the SPOP mutations.	Lysine	93-99	speckle type BTB/POZ protein	Homo sapiens	14-18
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	ubiquitin specific peptidase 7	Homo sapiens	15-19
19174535-4	2009	The CCR1 gene was previously isolated as EARLY FLOWERING IN SHORT DAYS and encodes a histone methyltransferase (SET DOMAIN GROUP 8) that methylates histone H3 on Lys 4 and/or 36 (H3K4 and H3K36).	Lysine	162-165	histone-lysine N-methyltransferase	Arabidopsis thaliana	4-8
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	sirtuin 7	Homo sapiens	35-40
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	sirtuin 7	Homo sapiens	101-106
28655758-7	2017	We showed that USP7 interacts with SIRT7 both in vitro and in vivo, and we further demonstrated that SIRT7 undergoes endogenous Lys-63-linked polyubiquitination, which is removed by USP7.	Lysine	128-131	ubiquitin specific peptidase 7	Homo sapiens	182-186
18381652-0	2008	PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster.	Lysine	89-96	protein kinase C, gamma	Rattus norvegicus	0-3
18381652-10	2008	These data suggest that the activation of PKC induces the ubiquitylation of these C-terminal lysine residues in GLT1 and that this modification mediates the interaction of the transporter with the endocytic machinery.	Lysine	93-99	protein kinase C, gamma	Rattus norvegicus	42-45
18381564-7	2008	Within MRP2 CL3, we identified a lysine-rich element that is essential for apical targeting.	Lysine	33-39	ATP binding cassette subfamily C member 2	Homo sapiens	7-11
19174535-4	2009	The CCR1 gene was previously isolated as EARLY FLOWERING IN SHORT DAYS and encodes a histone methyltransferase (SET DOMAIN GROUP 8) that methylates histone H3 on Lys 4 and/or 36 (H3K4 and H3K36).	Lysine	162-165	histone-lysine N-methyltransferase	Arabidopsis thaliana	112-130
19270745-11	2009	The PcG-associated histone modification, trimethylation of histone H3 lysine 27, is reduced in Asxl2(-/-) heart.	Lysine	70-76	ASXL transcriptional regulator 2	Mus musculus	95-100
18426905-8	2008	We recently established that the sumoylation of Tel on lysine 11 negatively regulates its repressive function and that the sumoylation of Tel monomers, but not that of Tel oligomers, may sensitize Tel for proteasomal degradation.	Lysine	55-61	Tel	Drosophila melanogaster	48-51
28673962-7	2017	Furthermore, our observed effects of in vitro acetylation on the canonical activities of IDH, MDH and LDH appeared to contrast with previous findings wherein acetyl-mimetic lysine mutations resulted in the inhibition of these enzymes.	Lysine	173-179	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	94-97
18854179-3	2008	We showed that CoREST can be modified by SUMO-1 at lysine 294.	Lysine	51-57	REST corepressor 1	Homo sapiens	15-21
28487115-7	2017	Further investigation revealed that HOXD-AS1 recruited WDR5 to directly regulate the expression of target genes by mediating histone H3 lysine 4 tri-methylation (H3K4me3).	Lysine	136-142	HOXD antisense growth-associated long non-coding RNA	Homo sapiens	36-44
18458063-6	2008	Another histone chaperone, Asf1, and Vps75 are both required for acetylation of lysine 9 on H3 (H3-K9ac) in vivo by Rtt109, whereas H3-K56ac in vivo requires only Asf1.	Lysine	80-86	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	27-31
18458063-6	2008	Another histone chaperone, Asf1, and Vps75 are both required for acetylation of lysine 9 on H3 (H3-K9ac) in vivo by Rtt109, whereas H3-K56ac in vivo requires only Asf1.	Lysine	80-86	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	116-122
18458063-6	2008	Another histone chaperone, Asf1, and Vps75 are both required for acetylation of lysine 9 on H3 (H3-K9ac) in vivo by Rtt109, whereas H3-K56ac in vivo requires only Asf1.	Lysine	80-86	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	163-167
18977234-5	2008	We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.	Lysine	156-159	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	171-174
28570922-10	2017	After sequential amino acid substitution, we found the binding capacity of P14-2 was completely lost by the substitution of cysteine (C) 132 and significantly decreased by the substitution of tryptophan (W) 136, lysine (K) 141, or glycine (G) 142, but still at a high level.	Lysine	212-218	ribonuclease P/MRP subunit p14	Homo sapiens	75-78
18977234-5	2008	We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.	Lysine	175-178	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	171-174
18568037-1	2008	Rtt109, also known as KAT11, is a recently characterized fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome stability.	Lysine	130-136	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	0-6
18840606-1	2008	WDR5 is a component of the mixed lineage leukemia (MLL) complex, which methylates lysine 4 of histone H3, and was identified as a methylated Lys-4 histone H3-binding protein.	Lysine	82-88	lysine methyltransferase 2A	Homo sapiens	51-54
18568037-1	2008	Rtt109, also known as KAT11, is a recently characterized fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome stability.	Lysine	130-136	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	22-27
18568037-5	2008	The structure reveals a buried autoacetylated lysine residue that we show is also acetylated in the Rtt109 protein purified from yeast cells.	Lysine	46-52	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	100-106
28374134-2	2017	It has previously been shown that knockout of lysine 63 deubiquitinase CYLD significantly inhibits necroptosis in other cell lines, and serum response factor (SRF) could regulate CYLD gene expression through p38 mitogen-activated protein kinase (p38 MAPK).	Lysine	46-52	CYLD lysine 63 deubiquitinase	Homo sapiens	71-75
18430729-4	2008	The results indicate that binding of the ShB peptide to KcsA involves the ortho and meta protons of Tyr(8), which exhibit the strongest STD effects; the C4H in the imidazole ring of His(16); the methyl protons of Val(4), Leu(7), and Leu(10) and the side chain amine protons of one, if not both, the Lys(18) and Lys(19) residues.	Lysine	299-302	SH2 domain containing adaptor protein B	Homo sapiens	41-44
18840612-0	2008	Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.	Lysine	63-69	tumor protein p53 binding protein 1	Homo sapiens	9-14
18430729-4	2008	The results indicate that binding of the ShB peptide to KcsA involves the ortho and meta protons of Tyr(8), which exhibit the strongest STD effects; the C4H in the imidazole ring of His(16); the methyl protons of Val(4), Leu(7), and Leu(10) and the side chain amine protons of one, if not both, the Lys(18) and Lys(19) residues.	Lysine	311-314	SH2 domain containing adaptor protein B	Homo sapiens	41-44
28571892-1	2017	Histone lysine specific demethylase 1 (LSD1) plays an important role in epigenetic modifications, and aberrant expression of LSD1 predicts tumor progression and poor prognosis in human esophageal cancers.	Lysine	8-14	lysine demethylase 1A	Homo sapiens	39-43
28571892-1	2017	Histone lysine specific demethylase 1 (LSD1) plays an important role in epigenetic modifications, and aberrant expression of LSD1 predicts tumor progression and poor prognosis in human esophageal cancers.	Lysine	8-14	lysine demethylase 1A	Homo sapiens	125-129
18559531-4	2008	Here, using mass spectrometry, we identified seven lysine residues in hsp90alpha that are hyperacetylated after treatment of eukaryotic cells with a pan-HDAC inhibitor that also inhibits HDAC6.	Lysine	51-57	histone deacetylase 9	Homo sapiens	153-157
18840612-8	2008	Here, we identify a novel p53 species that is dimethylated at lysine 382 (p53K382me2) and show that the tandem Tudor domain of the DNA damage response mediator 53BP1 acts as an "effector" for this mark.	Lysine	62-68	tumor protein p53 binding protein 1	Homo sapiens	160-165
18840612-9	2008	We demonstrate that the 53BP1 tandem Tudor domain recognizes p53K382me2 with a selectivity relative to several other protein lysine methylation sites and saturation states.	Lysine	125-131	tumor protein p53 binding protein 1	Homo sapiens	24-29
18523251-0	2008	Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.	Lysine	0-6	Nef	Human immunodeficiency virus 1	49-52
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Lysine	94-97	complement C1q A chain	Homo sapiens	54-57
18523251-0	2008	Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.	Lysine	0-6	Nef	Human immunodeficiency virus 1	70-73
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Lysine	4-10	Nef	Human immunodeficiency virus 1	22-25
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Lysine	74-81	Nef	Human immunodeficiency virus 1	22-25
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Lysine	74-80	Nef	Human immunodeficiency virus 1	22-25
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Lysine	74-80	Nef	Human immunodeficiency virus 1	22-25
18845545-0	2008	Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae.	Lysine	52-58	Spp1p	Saccharomyces cerevisiae S288C	98-102
18523251-7	2008	Lysine-free HIV-1 Nef was completely inactive in Nef-mediated CD4 down-regulation, so was the Nef mutant with a single arginine substitution at K144 but not at K204.	Lysine	0-6	Nef	Human immunodeficiency virus 1	18-21
18457426-2	2008	All three residues are also conserved in fXa and the X-ray crystal structure of fXa indicates that both Glu-217 and Lys-224 are within hydrogen-bonding distance from one another.	Lysine	116-119	coagulation factor X	Homo sapiens	41-44
18457426-2	2008	All three residues are also conserved in fXa and the X-ray crystal structure of fXa indicates that both Glu-217 and Lys-224 are within hydrogen-bonding distance from one another.	Lysine	116-119	coagulation factor X	Homo sapiens	80-83
28723896-5	2017	Integrated analyses of DNA methylome and tri-methylation at lysine 27 of histone H3 (H3K27me3) chromatin immunoprecipitation followed by sequencing identify 76 genes with paternal allele-specific DNase I hypersensitive sites that are devoid of DNA methylation but harbour maternal allele-specific H3K27me3.	Lysine	60-66	deoxyribonuclease I	Mus musculus	196-203
28753426-4	2017	Mechanistically, SETD2 directly mediates STAT1 methylation on lysine 525 via its methyltransferase activity, which reinforces IFN-activated STAT1 phosphorylation and antiviral cellular response.	Lysine	62-68	signal transducer and activator of transcription 1	Mus musculus	41-46
18457426-8	2008	These results suggest that, similar to thrombin, an ionic interaction between Glu-217 and Lys-224 stabilizes the 220-loop of fXa for binding Na (+).	Lysine	90-93	coagulation factor X	Homo sapiens	125-128
28753426-4	2017	Mechanistically, SETD2 directly mediates STAT1 methylation on lysine 525 via its methyltransferase activity, which reinforces IFN-activated STAT1 phosphorylation and antiviral cellular response.	Lysine	62-68	signal transducer and activator of transcription 1	Mus musculus	140-145
18845545-4	2008	Furthermore, we find that Orc2p physically interacts with trimethylated histone 3 lysine 4 (H3K4) on chromatin by co-immunoprecipitation.	Lysine	82-88	origin recognition complex subunit 2	Saccharomyces cerevisiae S288C	26-31
19035668-0	2008	Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody molecules.	Lysine	11-17	erb-b2 receptor tyrosine kinase 2	Mus musculus	105-109
28747667-2	2017	A novel synthetic histone 3 lysine 27 (H3K27) demethylase JMJD3 inhibitor, GSK-J4, was proven to exert immunosuppressive activities in macrophages.	Lysine	28-34	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	58-63
18520061-4	2008	However, conventional MEND is relatively large and heterogeneous (approximately 300 nm), probably because they contain relatively large- and heterogeneous-pDNA particles condensed with polycations, such as poly-L-lysine.	Lysine	206-219	EBP cholestenol delta-isomerase	Homo sapiens	22-26
19035668-12	2008	In conclusion, the substitution with one single lysine in the chelator results in better tumor imaging properties of the Affibody molecule Z(HER2:342) and is favorable for imaging of tumors and metastases in the abdominal area.	Lysine	48-54	erb-b2 receptor tyrosine kinase 2	Mus musculus	141-145
18438399-4	2008	DNA breaks swiftly mobilize heterochromatin protein 1 (HP1)-beta (also called CBX1), a chromatin factor bound to histone H3 methylated on lysine 9 (H3K9me).	Lysine	138-144	chromobox 1	Homo sapiens	28-64
18438399-4	2008	DNA breaks swiftly mobilize heterochromatin protein 1 (HP1)-beta (also called CBX1), a chromatin factor bound to histone H3 methylated on lysine 9 (H3K9me).	Lysine	138-144	chromobox 1	Homo sapiens	78-82
28430662-3	2017	JMJD3, as a histone demethylase, is capable of specifically removing the trimethyl group from the H3K27 lysine residue, triggering target gene activation.	Lysine	104-110	lysine demethylase 6B	Homo sapiens	0-5
19147908-2	2008	The hypertranscription involves acetylation of histone 4 at lysine 16 (H4K16) on amale X-chromosome, brought about by a histone acetyltransferase encoded by the dosage compensation gene, males absent on the first (mof).	Lysine	60-66	males absent on the first	Drosophila melanogaster	214-217
28900508-3	2017	In the present study, cross-linked dendrigraft poly-L-lysine (DGL) nanoparticles containing cis-aconitic anhydride-modified catalase and modified with PGP, an endogenous tripeptide that acts as a ligand with high affinity to neutrophils, were developed to form the cl PGP-PEG-DGL/CAT-Aco system.	Lysine	47-60	phosphoglycolate phosphatase	Mus musculus	151-154
29137219-2	2017	While the activities of lysine-specific demethylase 1 (LSD1/KDM1A) in facilitating breast cancer progression have been well characterized, the roles of its homolog LSD2 (KDM1B) in breast oncogenesis are relatively less understood.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	55-59
18497818-5	2008	The ATP gamma-phosphate is sensed across the RecA-RecA interface by two lysine residues that also stimulate ATP hydrolysis, providing a mechanism for DNA release.	Lysine	72-78	RAD51 recombinase	Homo sapiens	45-49
18497818-5	2008	The ATP gamma-phosphate is sensed across the RecA-RecA interface by two lysine residues that also stimulate ATP hydrolysis, providing a mechanism for DNA release.	Lysine	72-78	RAD51 recombinase	Homo sapiens	50-54
18498648-0	2008	Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.	Lysine	0-6	Tat	Human immunodeficiency virus 1	28-31
29137219-2	2017	While the activities of lysine-specific demethylase 1 (LSD1/KDM1A) in facilitating breast cancer progression have been well characterized, the roles of its homolog LSD2 (KDM1B) in breast oncogenesis are relatively less understood.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	60-65
18296440-0	2008	Preferential dimethylation of histone H4 lysine 20 by Suv4-20.	Lysine	41-47	Histone methyltransferase 4-20	Drosophila melanogaster	54-61
18787203-3	2008	DHDPS catalyzes the reaction of (S)-aspartate-beta-semialdehyde with pyruvate, which is bound via a Schiff base to a conserved active-site lysine (Lys161 in the enzyme from Escherichia coli).	Lysine	139-145	dihydrodipicolinate synthase	Escherichia coli	0-5
18296440-3	2008	The SET domain proteins PR-Set7 and Suv4-20 have been implicated in mono- and trimethylation, respectively; however, enzymes that dimethylate lysine 20 have not been identified.	Lysine	142-148	Histone methyltransferase 4-20	Drosophila melanogaster	36-43
18296440-4	2008	Here we report that Drosophila Suv4-20 is a mixed product specificity methyltransferase that dimethylates approximately 90% and trimethylates less than 5% of total H4 at lysine 20 in S2 cells.	Lysine	170-176	Histone methyltransferase 4-20	Drosophila melanogaster	31-38
20641691-15	2004	(13) showed that the kidney uptake of DOTA-NAPamide, a short linear DOTA-alpha-MSH analog, could be considerably reduced by neutralizing the charge of the Lys(11) residue.	Lysine	155-158	msh homeobox 1	Mus musculus	79-82
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	adrenoceptor alpha 1D	Homo sapiens	65-71
28549889-2	2017	We have previously developed inhibitors of BRD4, which recognizes acetylated lysine residue on histones and recruits transcription elongation factor to the transcription start site, while inhibitors of histone deacetylase (HDAC), which catalyzes the removal of acetyl groups on histones, are already in clinical use for cancer treatment.	Lysine	77-83	histone deacetylase 9	Homo sapiens	223-227
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Lysine	47-50	adrenoceptor alpha 1D	Homo sapiens	332-338
18757858-8	2008	The substitution of glutamate for lysine has a dramatic effect on the binding of gene 4 helicase to a DNA polymerase-thioredoxin complex lacking charges on loop B; binding is decreased 15-fold relative to that observed with wild-type thioredoxin.	Lysine	34-40	helicase	Escherichia phage T7	88-96
28683321-3	2017	We show here that the target of PINK1 polyubiquitination is the mature form and is mediated by ubiquitination of a conserved lysine at position 137.	Lysine	125-131	PTEN induced kinase 1	Homo sapiens	32-37
28683321-5	2017	On the basis of our data, we propose that cleavage of full-length PINK1 at Phe-104 disrupts the major hydrophobic membrane-spanning domain in the protein, inducing a conformation change in the resultant mature form that exposes Lys-137 to the cytosol for subsequent modification by the ubiquitination machinery.	Lysine	228-231	PTEN induced kinase 1	Homo sapiens	66-71
18355052-7	2008	Biotinylation of free Ku revealed several reactive lysines on Ku70 and Ku80 which were reduced or eliminated upon DNA binding.	Lysine	51-58	X-ray repair cross complementing 6	Homo sapiens	62-66
18201968-7	2008	We also found that suppression of STAT3, Oct-3/4, or Eed causes induction of differentiation-associated genes as well as loss of Lys(27)-trimethylated histone H3 at the promoter regions of the differentiation-associated genes.	Lysine	129-132	POU domain, class 5, transcription factor 1	Mus musculus	41-48
18977325-3	2008	ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias.	Lysine	43-49	lysine methyltransferase 2A	Homo sapiens	175-178
28541373-6	2017	We showed that the H3 lysine 9 acetylation (H3K9ac) status has the same correlation with Hoxc11 expression and reported that Gcn5 is associated with the upregulation of Hoxc11 expression through H3K9ac in Akt1-/- MEFs.	Lysine	22-28	K(lysine) acetyltransferase 2A	Mus musculus	125-129
18777182-1	2008	The 16-mer peptide nucleic acid sequence H-A GAT CAT GCC CGG CAT-Lys-NH2 (1), which is complementary to the translation start region of the N-myc oncogene messenger RNA, was synthesized and conjugated to a pyrazolyl diamine bifunctional chelator (pz).	Lysine	65-68	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	140-145
28501567-8	2017	Finally, we demonstrate that depletion of Jmjd1c interferes with mitotic clonal expansion (MCE), increases levels of H3K9me2 (dimethylation of lysine 9 of histone H3) at promotor regions of adipogenic transcription factors (C/EBPs and PPARgamma) and leads to reduced induction of these key regulators.	Lysine	143-149	jumonji domain containing 1C	Mus musculus	42-48
18318442-7	2008	Finally, we found that methylation of RASSF1 and SOCS2 promoters and the binding of trimethylated lysine 27 in histone 3 to these 2 genes was increased in HCC from GNMT-KO mice.	Lysine	98-104	glycine N-methyltransferase	Mus musculus	164-168
18936211-1	2008	Alpha-aminoadipate delta-semialdehyde synthase (AASS) is the bifunctional enzyme containing the lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase activities responsible for the first 2 steps in the irreversible catabolism of lysine.	Lysine	96-102	aminoadipate-semialdehyde synthase	Mus musculus	134-137
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Lysine	235-241	lysine acetyltransferase 2A	Homo sapiens	27-31
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Lysine	235-241	lysine acetyltransferase 2A	Homo sapiens	58-62
28672915-7	2017	Furthermore, the majority of the histone H3 at lysine 9 sites that interacted with the Oct4 and Sox2 promoters were acetylated, suggesting that the transcription activities of the above two transcription factors significantly increased.	Lysine	47-53	SRY-box transcription factor 2	Homo sapiens	96-100
18936211-1	2008	Alpha-aminoadipate delta-semialdehyde synthase (AASS) is the bifunctional enzyme containing the lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase activities responsible for the first 2 steps in the irreversible catabolism of lysine.	Lysine	96-102	aminoadipate-semialdehyde synthase	Mus musculus	143-169
18082865-6	2008	N-terminal lysine residues were shown to play a critical role in the Vif- and Vpr-mediated degradation of IRF-3.	Lysine	11-17	Vif	Human immunodeficiency virus 1	69-72
18936211-2	2008	A rare disease in humans, familial hyperlysinemia, can be caused by very low LKR activity and, as expected, reduces the lysine "requirement" of the individual.	Lysine	40-46	aminoadipate-semialdehyde synthase	Mus musculus	77-80
18676678-6	2008	Further investigation showed that a single amino acid residue, lysine 320 in CXCR2 and asparagine 311 in CXCR1, plays a predominant role in describing the relative antagonism of the two compounds.	Lysine	63-69	C-X-C chemokine receptor type 2	Bos taurus	77-82
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	55-61	cytochrome p450 oxidoreductase	Rattus norvegicus	16-19
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	55-61	heme oxygenase 1	Rattus norvegicus	30-34
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	72-75	cytochrome p450 oxidoreductase	Rattus norvegicus	16-19
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	72-75	heme oxygenase 1	Rattus norvegicus	30-34
28656888-4	2017	XIAP ubiquitinates a highly conserved Lys residue in AC isoforms and thereby accelerates the endocytosis and degradation of multiple AC isoforms in human cell lines and mice.	Lysine	38-41	X-linked inhibitor of apoptosis	Homo sapiens	0-4
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	84-87	cytochrome p450 oxidoreductase	Rattus norvegicus	16-19
18676678-6	2008	Further investigation showed that a single amino acid residue, lysine 320 in CXCR2 and asparagine 311 in CXCR1, plays a predominant role in describing the relative antagonism of the two compounds.	Lysine	63-69	C-X-C chemokine receptor type 2	Bos taurus	105-110
18194664-3	2008	The presence of CPR prevented HO-1 from acetylation of lysine residues, Lys-149 and Lys-153, located in the F-helix.	Lysine	84-87	heme oxygenase 1	Rattus norvegicus	30-34
18676678-7	2008	Homology modeling studies based on the structure of bovine rhodopsin indicated a potential intracellular antagonist binding pocket involving lysine 320.	Lysine	141-147	rhodopsin	Bos taurus	59-68
18194664-4	2008	The heme degradation activity of the fully acetylated HO-1 in the NADPH/CPR-supported system was significantly reduced, whereas almost no inactivation was detected in HO-1 in the presence of CPR, which prevented acetylation of Lys-149 and Lys-153.	Lysine	227-230	heme oxygenase 1	Rattus norvegicus	54-58
18194664-4	2008	The heme degradation activity of the fully acetylated HO-1 in the NADPH/CPR-supported system was significantly reduced, whereas almost no inactivation was detected in HO-1 in the presence of CPR, which prevented acetylation of Lys-149 and Lys-153.	Lysine	227-230	cytochrome p450 oxidoreductase	Rattus norvegicus	72-75
18194664-4	2008	The heme degradation activity of the fully acetylated HO-1 in the NADPH/CPR-supported system was significantly reduced, whereas almost no inactivation was detected in HO-1 in the presence of CPR, which prevented acetylation of Lys-149 and Lys-153.	Lysine	227-230	cytochrome p450 oxidoreductase	Rattus norvegicus	191-194
28445029-5	2017	Surprisingly, we also show that fragment-based NHS-ester ligands can be made to confer selectivity for specific lysine hotspots on specific targets including Dpyd, Aldh2, and Gstt1.	Lysine	112-118	dihydropyrimidine dehydrogenase	Homo sapiens	158-162
28445029-5	2017	Surprisingly, we also show that fragment-based NHS-ester ligands can be made to confer selectivity for specific lysine hotspots on specific targets including Dpyd, Aldh2, and Gstt1.	Lysine	112-118	glutathione S-transferase theta 1	Homo sapiens	175-180
18194664-4	2008	The heme degradation activity of the fully acetylated HO-1 in the NADPH/CPR-supported system was significantly reduced, whereas almost no inactivation was detected in HO-1 in the presence of CPR, which prevented acetylation of Lys-149 and Lys-153.	Lysine	239-242	heme oxygenase 1	Rattus norvegicus	54-58
18836456-3	2008	In this report, we show that Jhdm1b is a histone H3 lysine 36 (H3K36) demethylase.	Lysine	52-58	lysine demethylase 2B	Homo sapiens	29-35
18194664-4	2008	The heme degradation activity of the fully acetylated HO-1 in the NADPH/CPR-supported system was significantly reduced, whereas almost no inactivation was detected in HO-1 in the presence of CPR, which prevented acetylation of Lys-149 and Lys-153.	Lysine	239-242	cytochrome p450 oxidoreductase	Rattus norvegicus	191-194
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	140-143	RAD18 E3 ubiquitin protein ligase	Homo sapiens	63-68
18316726-5	2008	Also, similar to Rad5, HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.	Lysine	218-221	RAD18 E3 ubiquitin protein ligase	Homo sapiens	63-68
18212063-6	2008	Chromatin immunoprecipitation assays indicated that TopoIIbeta is bound to an RA response element and that inhibition of TopoIIbeta causes hyperacetylation of histone 3 at lysine 9 and activation of transcription.	Lysine	172-178	DNA topoisomerase II beta	Homo sapiens	52-62
18212063-6	2008	Chromatin immunoprecipitation assays indicated that TopoIIbeta is bound to an RA response element and that inhibition of TopoIIbeta causes hyperacetylation of histone 3 at lysine 9 and activation of transcription.	Lysine	172-178	DNA topoisomerase II beta	Homo sapiens	121-131
28623334-5	2017	TIP60 utilizes its NR Box to interact with LBD region of PXR and acetylates PXR at lysine 170 to induce its intranuclear reorganization.	Lysine	83-89	lysine acetyltransferase 5	Homo sapiens	0-5
28370702-3	2017	Through the process to search substrates for various methyltransferases using an in vitro methyltransferase assay, we found that a lysine methyltransferase, SET and MYND domain-containing 2 (SMYD2), could methylate lysine residues 1451, 1455, and 1610 in ALK protein.	Lysine	131-137	ALK receptor tyrosine kinase	Homo sapiens	255-258
28370702-5	2017	Substitutions of each of these three lysine residues to an alanine partially or almost completely diminished in vitro methylation of ALK.	Lysine	37-43	ALK receptor tyrosine kinase	Homo sapiens	133-136
18728004-5	2008	Tandem mass spectrometry sequencing of a diglycinated tryptic peptide identified Lys-628 as p110"s monoubiquitination site.	Lysine	81-84	spliceosome associated factor 3, U4/U6 recycling protein	Homo sapiens	92-96
28323958-3	2017	In the present report, we generated genetically modified mice lacking histone H3 lysine 27 (H3K27) demethylase Jumonji domain-containing 3 (JMJD3) in hypothalamic rat-insulin-promoter-expressing neurons (RIP-Cre neurons).	Lysine	81-87	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	111-138
28323958-3	2017	In the present report, we generated genetically modified mice lacking histone H3 lysine 27 (H3K27) demethylase Jumonji domain-containing 3 (JMJD3) in hypothalamic rat-insulin-promoter-expressing neurons (RIP-Cre neurons).	Lysine	81-87	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	140-145
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	55-58	nucleoporin 62	Homo sapiens	186-189
18082620-1	2008	RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3.	Lysine	87-93	PR/SET domain 2	Homo sapiens	0-4
18281463-7	2008	Strikingly, mutation of the two lysines at the NLS to arginines, or coexpression of a SUMO protease with wild-type PAP, caused PAP to be localized to the cytoplasm, demonstrating that sumoylation is required to facilitate PAP nuclear localization.	Lysine	32-39	poly(A) polymerase alpha	Homo sapiens	127-130
27871818-6	2017	The lysine-specific histone demethylase LSD1, which produces H2O2 as a by-product, was indentified as a local generator of 8-oxoG in some of these cases.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	40-44
18281463-7	2008	Strikingly, mutation of the two lysines at the NLS to arginines, or coexpression of a SUMO protease with wild-type PAP, caused PAP to be localized to the cytoplasm, demonstrating that sumoylation is required to facilitate PAP nuclear localization.	Lysine	32-39	poly(A) polymerase alpha	Homo sapiens	127-130
18793138-4	2008	Rsp5p catalyses the attachment of non-conventional ubiquitin chains, linked through ubiquitin Lys-63, to some endocytic and MVB cargoes.	Lysine	94-97	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	0-5
18344599-7	2008	Pirh2 preferentially utilized lysine residues 6 and 29 of the ubiquitin to mediate the formation of polyubiquitin chains on SRbeta.	Lysine	30-36	chaperonin containing TCP1 subunit 4	Homo sapiens	124-130
28428687-2	2017	Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins.	Lysine	94-100	lysyl oxidase	Homo sapiens	0-13
28428687-2	2017	Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins.	Lysine	94-100	lysyl oxidase	Homo sapiens	15-18
28428687-2	2017	Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins.	Lysine	94-100	elastin	Homo sapiens	113-120
18086879-4	2008	However, deletion of SLX5 had no detectable effect on the distribution of silent chromatin components and only slightly altered the deacetylation of histone H4 lysine 16 at the telomere.	Lysine	160-166	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	21-25
18625888-4	2008	Interestingly, the relative level of H3 lysine 4 dimethylation to trimethylation at B-specific loci was high in multipotent CD34(+)CD38(lo) progenitors and decreased as they become actively transcribed in B-lineage cells.	Lysine	40-46	CD38 molecule	Homo sapiens	131-135
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	42-48	receptor interacting serine/threonine kinase 2	Homo sapiens	18-22
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	42-48	receptor interacting serine/threonine kinase 2	Homo sapiens	194-198
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	83-89	receptor interacting serine/threonine kinase 2	Homo sapiens	18-22
28434735-16	2017	In conclusion, the decreased milk protein yield by graded Lys deficiency was mainly a result of the varied physiological status, as indicated by the elevated circulating glucagon and glucose, rather than a result of the decreased mammary Lys uptake or depressed signals in the mTOR pathway.	Lysine	58-61	serine/threonine-protein kinase mTOR	Capra hircus	277-281
18079694-4	2008	Here we show that RICK is conjugated with lysine-63-linked polyubiquitin chains at lysine 209 (K209) located in its kinase domain upon Nod1 or Nod2 stimulation and by induced oligomerization of RICK.	Lysine	83-89	receptor interacting serine/threonine kinase 2	Homo sapiens	194-198
18721140-11	2008	These and other results suggested that the nonapeptide generated by matrilysin treatment might be anchored to the cell membrane, possibly by binding to intact annexin II, and interact with tPA via its C-terminal lysine.	Lysine	212-218	matrix metallopeptidase 7	Homo sapiens	68-78
17998205-4	2008	Both Siah1 and Siah2 interacted with the RA2 domain of PLCepsilon, and the mutation of Lys-2186 of the PLCepsilon RA2 domain abolished this association.	Lysine	87-90	siah E3 ubiquitin protein ligase 2	Mus musculus	15-20
28471663-1	2017	LOXL2 catalyzes the oxidative deamination of epsilon-amines of lysine and hydroxylysine residues within collagen and elastin, generating reactive aldehydes (allysine).	Lysine	63-69	lysyl oxidase-like 2	Mus musculus	0-5
28542143-3	2017	Mutation of these lysine residues completely abrogates the binding of E2F1 to CCNE, TP73 and APAF1 promoters, thus inhibiting transcriptional activation of these genes and E2F1-mediated cell proliferation control.	Lysine	18-24	cyclin E1	Homo sapiens	78-82
18781795-0	2008	Modulation of retinoic acid receptor alpha activity by lysine methylation in the DNA binding domain.	Lysine	55-61	retinoic acid receptor alpha	Homo sapiens	14-42
28531096-0	2017	The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.	Lysine	4-7	crystallin gamma F, pseudogene	Homo sapiens	51-54
17879961-10	2008	The conformation of Alb changed due to glycation and L-Lys retained it similar to the native.	Lysine	53-58	albumin	Rattus norvegicus	20-23
18781795-1	2008	Metabolic labeling and detection with a methylated lysine-specific antibody confirm lysine methylation of RAR alpha in mammalian cells.	Lysine	51-57	retinoic acid receptor alpha	Homo sapiens	106-115
18173750-2	2008	In humans, the conventional Rad51 (HsRad51) protein has a Lys residue at position 313; however, the HsRad51-Q313 protein, in which the Lys313 residue is replaced by Gln, was reported as an isoform, probably corresponding to a polymorphic variant.	Lysine	58-61	RAD51 recombinase	Homo sapiens	35-42
18781795-1	2008	Metabolic labeling and detection with a methylated lysine-specific antibody confirm lysine methylation of RAR alpha in mammalian cells.	Lysine	84-90	retinoic acid receptor alpha	Homo sapiens	106-115
18173750-2	2008	In humans, the conventional Rad51 (HsRad51) protein has a Lys residue at position 313; however, the HsRad51-Q313 protein, in which the Lys313 residue is replaced by Gln, was reported as an isoform, probably corresponding to a polymorphic variant.	Lysine	58-61	RAD51 recombinase	Homo sapiens	100-107
18173750-6	2008	Mutational analyses of the HsRad51-Lys313 residue revealed that positively charged residues (Lys and Arg), but not negatively charged, polar and hydrophobic residues (Glu, Gln and Met, respectively), at position 313 reduced the strand-exchange and DNA unwinding abilities of the HsRad51 protein.	Lysine	35-38	RAD51 recombinase	Homo sapiens	27-34
18781795-7	2008	This study uncovers a potential role for monomethylation at Lys (109) in coordinating the synergy between DBD and LBD for ligand-dependent activation of RAR alpha.	Lysine	60-63	retinoic acid receptor alpha	Homo sapiens	153-162
28246193-2	2017	Genetic deletion of T-cell Ezh2, which catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3), inhibits GVHD.	Lysine	81-87	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	27-31
18852122-4	2008	Mutagenesis of these AR residues in helix 4, as well as mutation of lysine 720 in helix 3 (predicted to interact with the CoRNR box), markedly impaired AR recruitment of NCoR, indicating that N1 CoRNR box binding is being stabilized by these ionic interactions in the AR ligand-binding domain coactivator/corepressor binding site.	Lysine	68-74	nuclear receptor corepressor 1	Homo sapiens	170-174
18094255-5	2007	In cultured hippocampal neurons, although the two splice variants of Kv3.1, Kv3.1a and Kv3.1b, are differentially targeted to the somatodendritic and axonal membrane, respectively, the lysine-rich ATM is surprisingly common for both splice variants.	Lysine	185-191	potassium voltage-gated channel subfamily C member 1	Homo sapiens	69-74
18846226-7	2008	The presence of two chromodomains in KIS-L suggested that its recruitment or function might be regulated by the methylation of histone H3 lysine 4 by the trithorax group proteins ASH1 and TRX.	Lysine	138-144	absent, small, or homeotic discs 1	Drosophila melanogaster	179-183
17761950-3	2007	Here, we provide the first evidence of RXRalpha acetylation by p300 on lysine 145.	Lysine	71-77	retinoid X receptor alpha	Homo sapiens	39-47
27677533-4	2017	Under CL conditions, the estimated optimal SID Trp : Lys for average daily gain (ADG) was 19.7% whereas under UCL conditions these values were 20.5% and 19.0% for ADG and gain-to-feed ratio, respectively.	Lysine	53-56	ADG	Sus scrofa	81-84
27677533-6	2017	In conclusion, an SID Trp : Lys to optimize ADG for pigs raised under UCL conditions was higher (4%) than CL conditions.	Lysine	28-31	ADG	Sus scrofa	44-47
27765079-5	2017	Birds fed the lowest level of dietary lysine (1.016%) showed a lower expression of genes such as NADH dehydrogenase subunit I (ND1), cytochrome b (CYTB) and cytochrome c oxidase subunits I (COX I), II (COX II) and III (COX III), displaying the worst performance and body protein deposition.	Lysine	38-44	LOC100797098	Glycine max	133-145
27765079-5	2017	Birds fed the lowest level of dietary lysine (1.016%) showed a lower expression of genes such as NADH dehydrogenase subunit I (ND1), cytochrome b (CYTB) and cytochrome c oxidase subunits I (COX I), II (COX II) and III (COX III), displaying the worst performance and body protein deposition.	Lysine	38-44	LOC100797098	Glycine max	147-151
18846226-10	2008	A similar increase in H3 lysine 27 methylation was observed in ash1 and trx mutant larvae.	Lysine	25-31	absent, small, or homeotic discs 1	Drosophila melanogaster	63-67
27765079-5	2017	Birds fed the lowest level of dietary lysine (1.016%) showed a lower expression of genes such as NADH dehydrogenase subunit I (ND1), cytochrome b (CYTB) and cytochrome c oxidase subunits I (COX I), II (COX II) and III (COX III), displaying the worst performance and body protein deposition.	Lysine	38-44	cytochrome c oxidase subunit 2, mitochondrial	Glycine max	202-208
17924455-8	2007	By metabolome analysis of intracellular compounds, the amount of histidine and arginine is increased, and the amount of threonine, lysine and nicotinic acid is decreased in the Ami1p-overproducing strain as compared with the control, suggesting that Ami1p may hydrolyse some amides related to amino acid and niacin metabolism in the cell.	Lysine	131-137	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	177-182
18614528-3	2008	Here, we describe inhibitor-bound and inhibitor-free structures of the histone deacetylase-4 catalytic domain (HDAC4cd) and of an HDAC4cd active site mutant with enhanced enzymatic activity toward acetylated lysines.	Lysine	208-215	histone deacetylase 4	Homo sapiens	71-92
18614528-3	2008	Here, we describe inhibitor-bound and inhibitor-free structures of the histone deacetylase-4 catalytic domain (HDAC4cd) and of an HDAC4cd active site mutant with enhanced enzymatic activity toward acetylated lysines.	Lysine	208-215	histone deacetylase 4	Homo sapiens	111-116
18622015-7	2008	The recruitment of HDAC1 to c-Myc and FoxM1B promoters leads to deacetylation of histone H3 at Lys-9 on these E2F-dependent promoters.	Lysine	95-98	histone deacetylase 1	Mus musculus	19-24
17884818-5	2007	An in vivo acetylation assay using 293T cells revealed that Fli1 is mainly acetylated by the histone acetyltransferase activity of p300/CBP-associated factor (PCAF) at lysine 380.	Lysine	168-174	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	60-64
17884818-11	2007	These results indicate that PCAF-dependent acetylation of lysine 380 abrogates repressor function of Fli1 with respect to collagen gene expression.	Lysine	58-64	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	101-105
28236704-1	2017	Jumonji domain containing 2C (JMJD2C), also named as KDM4C, was found to a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysine 9 and 36.	Lysine	154-160	lysine demethylase 4C	Homo sapiens	0-28
28236704-1	2017	Jumonji domain containing 2C (JMJD2C), also named as KDM4C, was found to a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysine 9 and 36.	Lysine	154-160	lysine demethylase 4C	Homo sapiens	30-36
28236704-1	2017	Jumonji domain containing 2C (JMJD2C), also named as KDM4C, was found to a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysine 9 and 36.	Lysine	154-160	lysine demethylase 4C	Homo sapiens	53-58
17908689-7	2007	We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target genes, suggesting that acetylation is important for KLF4-mediated transactivation.	Lysine	130-137	Kruppel like factor 4	Homo sapiens	54-58
18805092-2	2008	Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates CRL ubiquitination activity and prevents binding of the inhibitor CAND1.	Lysine	95-101	interleukin 31 receptor A	Homo sapiens	113-116
17908689-7	2007	We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target genes, suggesting that acetylation is important for KLF4-mediated transactivation.	Lysine	130-137	Kruppel like factor 4	Homo sapiens	173-177
17908689-7	2007	We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target genes, suggesting that acetylation is important for KLF4-mediated transactivation.	Lysine	130-137	Kruppel like factor 4	Homo sapiens	173-177
28580118-5	2017	By applying advanced chemical strategies for protein synthesis, we report the first total chemical synthesis of four different SUMO-2-Lys63-linked di-ubiquitin hybrid chains, in which the di-ubiquitin is linked to different lysines in SUMO.	Lysine	224-231	small ubiquitin like modifier 2	Homo sapiens	127-133
28275050-0	2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).	Lysine	33-39	CEA cell adhesion molecule 1	Homo sapiens	45-102
18004385-5	2007	SIRT1 is an NAD+-dependent deacetylase that targets histone H4 at lysine 16 (refs 3 and 4), and through an unknown mechanism facilitates increased levels of H3K9me3 (ref.	Lysine	66-72	sirtuin 1	Homo sapiens	0-5
28275050-0	2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).	Lysine	33-39	CEA cell adhesion molecule 1	Homo sapiens	104-111
28275050-0	2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).	Lysine	33-39	N-myc downstream regulated 1	Homo sapiens	243-248
18489260-3	2008	The residues Thr(886) and Lys(890) of the PI3Kgamma isoform project towards the ATP-binding pocket at the entrance to the catalytic site, but are not conserved.	Lysine	26-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	42-51
17932512-2	2007	The two malignant brain tumour (MBT) repeats of Scm form a domain that preferentially binds to monomethylated lysine residues either as a free amino acid or in the context of peptides, while unmodified or di- or trimethylated lysine residues are bound with significantly lower affinity.	Lysine	110-116	Sex comb on midleg	Drosophila melanogaster	48-51
17932512-2	2007	The two malignant brain tumour (MBT) repeats of Scm form a domain that preferentially binds to monomethylated lysine residues either as a free amino acid or in the context of peptides, while unmodified or di- or trimethylated lysine residues are bound with significantly lower affinity.	Lysine	226-232	Sex comb on midleg	Drosophila melanogaster	48-51
17924656-9	2007	We demonstrate that ActRIIbE76K and ActRII bind BMP-3 with similar affinity, indicating BMP-3 receptor specificity is controlled by the interaction of Lys-30 of BMP-3 with Glu-76 of ActRIIb.	Lysine	151-154	activin A receptor type 2B	Homo sapiens	20-27
18596036-9	2008	This information allows us to propose a model of the MBL-MASP-1/3 interaction, involving a major electrostatic interaction between two acidic Ca(2+) ligands of MASP-1/3 and a conserved lysine of MBL.	Lysine	185-191	mannose binding lectin 2	Homo sapiens	195-198
18602372-3	2008	Knockout mutations of the SDG8 gene markedly reduce the global levels of histone H3 trimethylation at lysines 9 and 36 as well as dimethylation at lysine 36.	Lysine	102-109	histone-lysine N-methyltransferase	Arabidopsis thaliana	26-30
17713478-5	2007	Here we show that the human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3.	Lysine	101-104	lysine demethylase 6B	Homo sapiens	68-73
28126510-8	2017	The events that possibly overlay include OS-induced sequestration of SIRT1 to caveolae facilitating cav1-SIRT1 association; potential increase in lysine acetylation of enzymes such as eNOS and PRMT1 leading to enhanced ADMA formation; imbalance in acetylation-methylation ratio (AMR); diminished NO generation and ED.	Lysine	146-152	protein arginine methyltransferase 1	Homo sapiens	193-198
18602372-3	2008	Knockout mutations of the SDG8 gene markedly reduce the global levels of histone H3 trimethylation at lysines 9 and 36 as well as dimethylation at lysine 36.	Lysine	102-108	histone-lysine N-methyltransferase	Arabidopsis thaliana	26-30
28378777-5	2017	Although LH2 protein levels did not change, FKBP65 deficiency significantly diminished HLCCs and increased the non-hydroxylated lysine-aldehyde-derived collagen cross-links (LCCs), a pattern consistent with loss of LH2 enzymatic activity.	Lysine	128-134	FK506 binding protein 10	Mus musculus	44-50
18621737-9	2008	Furthermore, we reconstitute the ubiquitination process with purified components in vitro and demonstrate that c-IAP1, in collaboration with the ubiquitin conjugating enzyme (E2) enzyme UbcH5a, mediates polymerization of Lys-63-linked chains on RIP1.	Lysine	221-224	baculoviral IAP repeat-containing 3	Mus musculus	111-117
17894561-7	2007	The DGAT1 allele that encodes lysine (K) at position 232 (232K) is associated with more saturated fat; a larger fraction of C16:0; and smaller fractions of C14:0, unsaturated C18 and conjugated linoleic acid (P &lt; 0.001).	Lysine	30-36	diacylglycerol O-acyltransferase 1	Bos taurus	4-9
18757404-5	2008	In this report, we show that PTEN is acetylated on Lys(402), which is in the COOH-terminal PDZ domain-binding motif.	Lysine	51-54	phosphatase and tensin homolog	Homo sapiens	29-33
17468514-14	2007	Our data suggest that the induction of a single enzyme, LSD1, represents an early response to carcinogen exposure, which leads to the demethylation of histone H3 (Lys 4), which, in turn, may influence the expression of multiple genes critical in early-stage mammary carcinogenesis.	Lysine	163-166	lysine demethylase 1A	Homo sapiens	56-60
28121484-10	2017	Interestingly, SYVN1-mediated lysine 48 (K48)-linked polyubiquitin chains that conjugated onto SERPINA1E342K/ATZ might predominantly bind to the ubiquitin-associated (UBA) domain of SQSTM1 and couple the ubiquitinated SERPINA1E342K/ATZ to the lysosome for degradation.	Lysine	30-36	sequestosome 1	Homo sapiens	182-188
18757404-7	2008	Interestingly, Lys(402) acetylation modulates PTEN interaction with PDZ domain-containing proteins, indicating a potential role of acetylation in regulating PTEN function.	Lysine	15-18	phosphatase and tensin homolog	Homo sapiens	46-50
18757404-7	2008	Interestingly, Lys(402) acetylation modulates PTEN interaction with PDZ domain-containing proteins, indicating a potential role of acetylation in regulating PTEN function.	Lysine	15-18	phosphatase and tensin homolog	Homo sapiens	157-161
28355556-4	2017	Ubiquitylation of CMG in yeast cell extracts is dependent upon lysine 29 of Mcm7, which is the only detectable site of ubiquitylation both in vitro and in vivo (though in vivo other sites can be modified when K29 is mutated).	Lysine	63-69	mini-chromosome maintenance complex protein 7	Saccharomyces cerevisiae S288C	76-80
17728347-1	2007	Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling.	Lysine	139-146	delta/notch-like EGF repeat containing	Mus musculus	52-55
18660751-2	2008	Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi intermediate compartment (ER/ERGIC).	Lysine	55-61	beta-site APP cleaving enzyme 1	Mus musculus	14-19
17880717-2	2007	In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4.	Lysine	88-94	histone acetyltransferase	Saccharomyces cerevisiae S288C	28-53
17713929-0	2007	Alkaline conformational transition and gated electron transfer with a Lys 79 --&gt; his variant of iso-1-cytochrome c.	Lysine	70-73	eukaryotic translation initiation factor 1	Homo sapiens	99-104
28290497-1	2017	Sister-chromatid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit.	Lysine	94-101	SMC protein	Xenopus laevis	117-121
28135087-2	2017	GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates.	Lysine	90-96	euchromatic histone lysine methyltransferase 2	Homo sapiens	8-11
17713929-1	2007	To probe the mechanism of the alkaline conformational transition and its effect on the dynamics of gated electron transfer (ET) reactions, a Lys 79 --&gt; His (K79H) variant of iso-1-cytochrome c has been prepared.	Lysine	141-144	eukaryotic translation initiation factor 1	Homo sapiens	177-182
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	48-52
17707228-8	2007	LSD1 depletion derepresses Gfi targets in lineage-specific patterns, accompanied by enhanced histone 3 lysine 4 methylation at the respective promoters.	Lysine	103-109	lysine demethylase 1A	Homo sapiens	0-4
17707230-3	2007	G9a methylates histone H3 on lysine 9 (H3K9me2) in the pre-rRNA coding region and facilitates the association of heterochromatin protein 1gamma (HP1gamma) with rDNA.	Lysine	29-35	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
17517433-10	2007	The ERM domain of STIM1 binds to TRPC channels and a lysine-rich region participates in the gating of SOCs and TRPC1.	Lysine	53-59	transient receptor potential cation channel subfamily C member 1	Homo sapiens	111-116
28435523-1	2017	Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation.	Lysine	76-82	lysine demethylase 1A	Homo sapiens	0-29
28435523-1	2017	Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation.	Lysine	76-82	lysine demethylase 1A	Homo sapiens	31-35
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	SET and MYND domain containing 2	Homo sapiens	55-60
17544230-6	2007	Under the same experimental condition, lysine to arginine substitution of histone H3 at position 36 abolished the methyltransferase activity of Drosophila ASH1, suggesting that K36 is their specific target.	Lysine	39-45	keratin 36	Homo sapiens	177-180
18581285-6	2008	Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines.	Lysine	124-131	SET and MYND domain containing 2	Homo sapiens	62-67
18719106-6	2008	HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-linked polyubiquitination of PCNA.	Lysine	77-83	helicase-like transcription factor	Mus musculus	0-4
17559874-6	2007	The PLP cofactor is bound covalently to a lysine residue (Lys265) as an internal aldimine/Schiff base and the active site is composed of residues from both subunits, located at the bottom of a deep cleft.	Lysine	42-48	proteolipid protein 1	Homo sapiens	4-7
17525156-6	2007	Taken together, these findings indicate that a general function of histone demethylases for H3 Lys(36) is to promote transcription elongation by antagonizing repressive Lys(36) methylation by Set2.	Lysine	95-98	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	192-196
17525156-6	2007	Taken together, these findings indicate that a general function of histone demethylases for H3 Lys(36) is to promote transcription elongation by antagonizing repressive Lys(36) methylation by Set2.	Lysine	169-172	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	192-196
28406750-5	2017	SIRT7 is recruited to DSBs, where it specifically deacetylates histone H3 at lysine 18 and affects the focal accumulation of the DNA damage response factor 53BP1, thus influencing the efficiency of repair.	Lysine	77-83	sirtuin 7	Mus musculus	0-5
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	71-77	sirtuin 1	Homo sapiens	18-39
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	71-77	sirtuin 1	Homo sapiens	41-46
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	114-120	sirtuin 1	Homo sapiens	18-39
18688484-8	2008	Chloride transport diminished significantly for the free lysine containing SAT, 2, when the lipid was altered from DOPC : DOPA to pure DOPC.	Lysine	57-63	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	75-81
28191886-3	2017	Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plasma membrane.	Lysine	114-120	sirtuin 1	Homo sapiens	41-46
28191886-6	2017	Increased Sirt1 activity or expression results in decreased lysine acetylation of Nav1.5, which promotes the trafficking of Nav1.5 to the plasma membrane and stimulation of INa.	Lysine	60-66	sirtuin 1	Homo sapiens	10-15
17590016-8	2007	Using mass spectrometry, two p300 HAT lysine acetylation sites were mapped in ATF-2 b-ZIP.	Lysine	38-44	activating transcription factor 2	Homo sapiens	78-83
17590016-8	2007	Using mass spectrometry, two p300 HAT lysine acetylation sites were mapped in ATF-2 b-ZIP.	Lysine	38-44	death associated protein kinase 3	Homo sapiens	86-89
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	72-77
17517887-2	2007	When DNA damage is encountered, PCNA is monoubiquitinated on Lys-164 by the Rad6-Rad18 complex as the initiating step of translesion synthesis.	Lysine	61-64	RAD18 E3 ubiquitin protein ligase	Homo sapiens	81-86
28245818-1	2017	BACKGROUND: Microbial transglutaminase (mTG) is a robust enzyme catalyzing the formation of an isopeptide bond between glutamine and lysine residues.	Lysine	133-139	protease, serine 3	Mus musculus	40-43
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	83-88
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	83-88
17472963-2	2007	In this study, we hypothesized that the specific interaction site for C1P was localized to the cationic beta-groove (Arg(57), Lys(58), Arg(59)) of the C2 domain of cPLA(2)alpha.	Lysine	126-129	phospholipase A2 group IVA	Homo sapiens	164-176
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	83-88
28230157-4	2017	Using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metalloproteinases (MMP2 and MMP9), we demonstrated that substrates containing ACC/Lys(DNP) exhibit 7 to 10 times higher sensitivity than conventional 7-methoxy-coumarin-4-yl acetic acid (MCA)/Lys(DNP) substrates; thus, substantially lower amounts of substrate and enzyme can be used for each assay.	Lysine	168-171	matrix metallopeptidase 9	Homo sapiens	114-118
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	83-88
27977123-9	2017	This information is particularly important for those using yeast display technology, as library members with Ali/Leu-X-Lys/Arg-Arg patterns are likely being removed from screens via Kex2 cleavage without the researcher"s knowledge.	Lysine	119-122	kexin KEX2	Saccharomyces cerevisiae S288C	182-186
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Lysine	255-261	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	32-36
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Lysine	255-261	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	61-65
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Lysine	255-261	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	32-40
18338323-8	2008	We found that the Pro or Lys to Ala substitution within the residues of CKLF1-C19 (CKLF1-C19pm or CKLF1-C19km) strongly decreased or abolished its interaction with heparin, suggesting that the residues of Pro affect the affinity of CKLF1-C19 for heparin, and the residues of Lys of CKLF1-C19 play the important role for the interaction of CKLF1-C19 and heparin, respectively.	Lysine	25-28	chemokine like factor	Homo sapiens	83-88
18247344-11	2008	The chemical shift perturbation and the cross saturation experiments of the human ACC2 holo-biotinoyl upon the addition of the biotin ligase (BirA) showed the interaction surface near the MKM motif, the two glutamic acids (Glu 926, Glu 953), and the positively charged residues (several lysine and arginine residues).	Lysine	287-293	acetyl-CoA carboxylase beta	Homo sapiens	82-86
17498654-2	2007	Here, we show that transcription factor PLZF can be SUMO modified at lysine residue 242, 387 and 396.	Lysine	69-75	zinc finger and BTB domain containing 16	Homo sapiens	40-44
28212444-5	2017	Using in vitro and in vivo SUMOylation assays, we found that JMJD2A is SUMOylated on lysine 471 by KSHV K-bZIP, a viral SUMO-2/3-specific E3 ligase, in a SUMO-interacting motif (SIM)-dependent manner.	Lysine	85-91	lysine demethylase 4A	Homo sapiens	61-67
17567753-2	2007	The Jumonji C-containing oxygenase JMJD2A specifically demethylates tri- and dimethylated lysine-9 and lysine-36 of histone 3 (H3K9/36 me3/2).	Lysine	90-96	lysine demethylase 4A	Homo sapiens	35-41
18408040-1	2008	Solid-state NMR study shows that the 22-residue K3 peptide (Ser(20)-Lys(41)) from beta(2)-microglobulin (beta(2)m) adopts a beta-strand-loop-beta-strand conformation in its fibril state.	Lysine	68-71	beta-2-microglobulin	Homo sapiens	82-103
17567753-2	2007	The Jumonji C-containing oxygenase JMJD2A specifically demethylates tri- and dimethylated lysine-9 and lysine-36 of histone 3 (H3K9/36 me3/2).	Lysine	103-109	lysine demethylase 4A	Homo sapiens	35-41
17516661-9	2007	These data support a model of surface-surface interactions between the negative charges present on rAFnBPA and the positive lysines of tropoelastin.	Lysine	124-131	elastin	Homo sapiens	135-147
28212444-5	2017	Using in vitro and in vivo SUMOylation assays, we found that JMJD2A is SUMOylated on lysine 471 by KSHV K-bZIP, a viral SUMO-2/3-specific E3 ligase, in a SUMO-interacting motif (SIM)-dependent manner.	Lysine	85-91	small ubiquitin like modifier 2	Homo sapiens	120-126
28115688-7	2017	In brains of the same mice we found a significant three-way interaction on corticotropin-releasing hormone receptor-1 (Crhr1) gene expression, in the left hippocampus specifically, which co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4 trimethylation (H3K4me3) over the Crhr1 promoter.	Lysine	252-258	corticotropin releasing hormone receptor 1	Mus musculus	75-117
28115688-7	2017	In brains of the same mice we found a significant three-way interaction on corticotropin-releasing hormone receptor-1 (Crhr1) gene expression, in the left hippocampus specifically, which co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4 trimethylation (H3K4me3) over the Crhr1 promoter.	Lysine	252-258	corticotropin releasing hormone receptor 1	Mus musculus	119-124
18408040-1	2008	Solid-state NMR study shows that the 22-residue K3 peptide (Ser(20)-Lys(41)) from beta(2)-microglobulin (beta(2)m) adopts a beta-strand-loop-beta-strand conformation in its fibril state.	Lysine	68-71	beta-2-microglobulin	Homo sapiens	105-113
17452315-7	2007	Residues Glu(61) and Lys(63) of beta-strand C and Leu(72) of beta-strand C" in the dimer interface are required for efficient JAM-A engagement of strain type 3 Dearing sigma1.	Lysine	21-24	F11 receptor	Homo sapiens	126-131
28158205-3	2017	Lysine specific demethylase 1 (LSD1), which can demethylate histone H3 lysine 4 (H3K4) and other proteins, has recently been found to be a drug target for acute myeloid leukemia.	Lysine	71-77	lysine demethylase 1A	Homo sapiens	0-29
18399914-1	2008	The regeneration of bovine rhodopsin from its apoprotein opsin and the prosthetic group 11-cis retinal involves the formation of a retinylidene Schiff base with the epsilon-amino group of the active lysine residue of opsin.	Lysine	199-205	rhodopsin	Bos taurus	27-36
28158205-3	2017	Lysine specific demethylase 1 (LSD1), which can demethylate histone H3 lysine 4 (H3K4) and other proteins, has recently been found to be a drug target for acute myeloid leukemia.	Lysine	71-77	lysine demethylase 1A	Homo sapiens	31-35
18467496-8	2008	Combining information from the alanine, lysine, and glutamic acid scans has enabled us to identify Bim BH3 domain mutants containing only two or three sequence changes that bind very selectively either to Bcl-x(L) or Mcl-1.	Lysine	40-46	BCL2 like 11	Homo sapiens	99-102
27623388-5	2017	ChIP analysis of macrophages from nondiabetic or diabetic mice was performed to determine acetylation of lysine 9 in histone H3 in MyD88 and STAT1 promoter regions.	Lysine	105-111	myeloid differentiation primary response gene 88	Mus musculus	131-136
17511474-1	2007	Lysine-specific demethylase 1 (LSD1) is a transcriptional repressor and a flavin-dependent amine oxidase that is responsible for the removal of methyl from lysine 4 of histone H3.	Lysine	156-162	lysine demethylase 1A	Homo sapiens	0-29
17511474-1	2007	Lysine-specific demethylase 1 (LSD1) is a transcriptional repressor and a flavin-dependent amine oxidase that is responsible for the removal of methyl from lysine 4 of histone H3.	Lysine	156-162	lysine demethylase 1A	Homo sapiens	31-35
17554311-6	2007	We found that Arabidopsis histone H2B is monoubiquitinated at lysine 143 and that the levels of ubiquitinated H2B and trimethyl H3 at lysine 4 increase in sup32 mutant plants.	Lysine	62-68	Histone superfamily protein	Arabidopsis thaliana	34-37
17540172-4	2007	Consistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.	Lysine	167-173	H1.4 linker histone, cluster member	Homo sapiens	155-166
18321858-4	2008	Based on PT1-docked AMPK alpha1 subunit structure model and different mutations, we found PT1 might interact with Glu-96 and Lys-156 residues near the autoinhibitory domain and directly relieve autoinhibition.	Lysine	125-128	zinc finger protein 77	Homo sapiens	9-12
17545996-4	2007	Furthermore, lysine acetylation occurs in cellular structure proteins such as alpha-tubulin, actin, cortactin and p120 catenin.	Lysine	13-19	cortactin	Homo sapiens	100-109
27903753-1	2017	Dysregulation of lysine (K)-specific demethylase 1A (LSD1), also known as KDM1A, has been implicated in the development of various cancers, including leukemia.	Lysine	17-23	lysine demethylase 1A	Homo sapiens	53-57
27903753-1	2017	Dysregulation of lysine (K)-specific demethylase 1A (LSD1), also known as KDM1A, has been implicated in the development of various cancers, including leukemia.	Lysine	17-23	lysine demethylase 1A	Homo sapiens	74-79
18321858-4	2008	Based on PT1-docked AMPK alpha1 subunit structure model and different mutations, we found PT1 might interact with Glu-96 and Lys-156 residues near the autoinhibitory domain and directly relieve autoinhibition.	Lysine	125-128	zinc finger protein 77	Homo sapiens	90-93
17403718-6	2007	There was a significant shift in the balance between methylation and acetylation in treated HD mice to that found in wild-type mice, resulting in greater acetylation of histone H3 at lysine 9 and promoting gene transcription.	Lysine	183-189	H3 clustered histone 7	Mus musculus	169-179
18490743-9	2008	Using fluorescent chimeras of the extracellular domain of mouse CD8beta fused to the cytoplasmic tails of each isoform, the M-2 isoform was localized in a lysosomal compartment regulated by ubiquitination of a lysine residue (K215) in its cytoplasmic tail.	Lysine	210-216	cholinergic receptor, muscarinic 2, cardiac	Mus musculus	124-127
17369253-3	2007	We and others have shown that the histone acetyltransferase (HAT) Rtt109 is the primary HAT responsible for acetylating H3-Lys-56 in budding yeast.	Lysine	123-126	histone acetyltransferase	Saccharomyces cerevisiae S288C	34-59
17369253-3	2007	We and others have shown that the histone acetyltransferase (HAT) Rtt109 is the primary HAT responsible for acetylating H3-Lys-56 in budding yeast.	Lysine	123-126	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	66-72
28361100-2	2017	EHMT1 (MIM# 607001) encodes a histone methyltransferase that heterodimerizes with EHMT2 (also known as G9a, MIM# 604599), which together are responsible for mono- and dimethylation of H3 lysine 9 (H3K9me1 and -me2), resulting in transcriptional repression of target genes.	Lysine	187-193	euchromatic histone lysine methyltransferase 2	Homo sapiens	82-87
28361100-2	2017	EHMT1 (MIM# 607001) encodes a histone methyltransferase that heterodimerizes with EHMT2 (also known as G9a, MIM# 604599), which together are responsible for mono- and dimethylation of H3 lysine 9 (H3K9me1 and -me2), resulting in transcriptional repression of target genes.	Lysine	187-193	euchromatic histone lysine methyltransferase 2	Homo sapiens	103-106
17369253-5	2007	In addition, both recombinant and native Rtt109-Vps75 HAT complexes exhibited no detectable activity toward nucleosomal H3, suggesting that H3-Lys-56 acetylation is at least in part regulated by the inability of Rtt109-Vps75 complexes to acetylate nucleosomal H3 during G(2)/M phase of the cell cycle.	Lysine	143-146	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	41-47
18510926-2	2008	Here we report that the histone H4 lysine 16 (H4K16) specific histone acetyltransferase MOF displays differential binding behavior depending on whether the target gene is located on the X chromosome versus the autosomes.	Lysine	35-41	males absent on the first	Drosophila melanogaster	88-91
17337443-4	2007	IRAK-4 kinase was rendered inactive by mutating the conserved lysine residues in the ATP pocket essential for coordinating ATP.	Lysine	62-68	interleukin-1 receptor-associated kinase 4	Mus musculus	0-6
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Lysine	33-39	sirtuin 7	Homo sapiens	13-18
27997115-10	2017	Knockdown of SIRT7 increased the lysine fatty acylation of several nuclear proteins based on metabolic labeling with an alkyne-tagged fatty acid analog, supporting that the defatty-acylase activity of SIRT7 is physiologically relevant.	Lysine	33-39	sirtuin 7	Homo sapiens	201-206
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	NADPH oxidase 3	Homo sapiens	244-248
27799292-3	2017	FADD was modified at multiple lysine residues (K120/125/149) by small ubiquitin-related modifier 2 (SUMO2) during necrosis caused by calcium ionophore A23187 and by ischemic damage.	Lysine	30-36	small ubiquitin like modifier 2	Homo sapiens	64-98
17344478-10	2007	Arn1 was preferentially modified with polyubiquitin chains on a cluster of lysine residues at the amino terminus of the transporter.	Lysine	75-81	siderophore transporter	Saccharomyces cerevisiae S288C	0-4
27799292-3	2017	FADD was modified at multiple lysine residues (K120/125/149) by small ubiquitin-related modifier 2 (SUMO2) during necrosis caused by calcium ionophore A23187 and by ischemic damage.	Lysine	30-36	small ubiquitin like modifier 2	Homo sapiens	100-105
17447102-1	2007	In Saccharomyces cerevisiae histone H2B is ubiquitylated at lysine 123 in a process requiring the E2-ubiquitin conjugase, Rad6.	Lysine	60-66	histone H2B	Saccharomyces cerevisiae S288C	28-39
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	NADPH oxidase 5	Homo sapiens	276-280
17447102-3	2007	The SAGA complex component, Ubp8, is one of two proteases that remove the ubiquitin moiety at lysine 123.	Lysine	94-100	ubiquitin-specific protease UBP8	Saccharomyces cerevisiae S288C	28-32
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	NADPH oxidase 3	Homo sapiens	244-248
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	NADPH oxidase 5	Homo sapiens	276-280
18356165-5	2008	HDAC6 deacetylates beta-catenin at lysine 49, a site frequently mutated in anaplastic thyroid cancer, and inhibits beta-catenin phosphorylation at serine 45.	Lysine	35-41	catenin beta 1	Homo sapiens	19-31
17310064-5	2007	Indeed, the loss of function resulting from the mutation of the conserved lysine residue into aspartate or glutamate in the TM3 of gamma-aminobutyric acid type B(2) can be partly rescued by mutating the conserved acidic residue of TM6 into either lysine or arginine.	Lysine	74-80	tropomyosin 3	Homo sapiens	124-127
17310064-5	2007	Indeed, the loss of function resulting from the mutation of the conserved lysine residue into aspartate or glutamate in the TM3 of gamma-aminobutyric acid type B(2) can be partly rescued by mutating the conserved acidic residue of TM6 into either lysine or arginine.	Lysine	247-253	tropomyosin 3	Homo sapiens	124-127
27840081-2	2017	A point mutation converting lysine 44 of Dyn2 to alanine (Dyn2K44A) disrupts its GTPase activity.	Lysine	28-34	dynamin 2	Mus musculus	41-45
27592546-2	2017	Histone deacetylase (HDAC) enzymes can exert their functions in the epigenetic regulation of gene expression related to oncogenesis via deacetylating the lysine residues of histones in the chromatin and various non-histone proteins.	Lysine	154-160	histone deacetylase 9	Homo sapiens	0-19
17391064-7	2007	Through screening of a panel of fluorogenic and chromogenic peptide substrates, we establish that active KLK12 possesses trypsin-like activity, cleaving peptide bonds after both arginine and lysine.	Lysine	191-197	kallikrein related peptidase 12	Homo sapiens	105-110
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Lysine	103-106	laminin, alpha 1	Mus musculus	221-235
18445155-6	2008	The heat shock protein Hsp90 was identified by peptide sequencing as a major fluorescent band on SDS-PAGE of lysine-labelled Walker cell extracts.	Lysine	109-115	heat shock protein 90 alpha family class A member 1	Homo sapiens	23-28
17965588-3	2007	Here we show that the Arabidopsis homolog of Trithorax, ATX1, activates the expression of the WRKY70 gene and is involved in establishing the trimethylation pattern of histone H3 tail lysine 4 (H3K4me3) residues of its nucleosomes.	Lysine	184-190	WRKY DNA-binding protein 70	Arabidopsis thaliana	94-100
17267497-5	2007	The overall negative charge of this 3-amino-acid motif appears critical for recognition by Vif, as single lysine substitutions are particularly deleterious and a double alanine substitution at positions 128 and 130 is far more inhibitory than single-residue mutations at either position.	Lysine	106-112	Vif	Human immunodeficiency virus 1	91-94
27592546-2	2017	Histone deacetylase (HDAC) enzymes can exert their functions in the epigenetic regulation of gene expression related to oncogenesis via deacetylating the lysine residues of histones in the chromatin and various non-histone proteins.	Lysine	154-160	histone deacetylase 9	Homo sapiens	21-25
28966236-8	2017	In conclusion, our results support the view that LOX and tropoelastin are present on the cell surface and suggests the possibility that lysine oxidation by LOX precedes tropoelastin deposition onto microfibrils.	Lysine	136-142	lysyl oxidase	Homo sapiens	156-159
18391193-1	2008	Molecular dynamics and hybrid quantum mechanics/molecular mechanics have been used to investigate the mechanisms of (+)AdoMet methylation of protein-Lys-NH(2) catalyzed by the lysine methyltransferase enzymes: histone lysine monomethyltransferase SET7/9, Rubisco large-subunit dimethyltransferase, viral histone lysine trimethyltransferase, and the Tyr245Phe mutation of SET7/9.	Lysine	149-152	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	247-253
27249374-8	2017	RESULTS: In fibrovascular tissues, FDP-Lys staining was found in vascular components containing CD34-positive cells and alpha smooth muscle actin (alpha-SMA)-positive cells, and clusters of rabbit anti-glial fibrillary acid protein (GFAP)-positive cells.	Lysine	39-42	glial fibrillary acidic protein	Homo sapiens	197-231
27249374-8	2017	RESULTS: In fibrovascular tissues, FDP-Lys staining was found in vascular components containing CD34-positive cells and alpha smooth muscle actin (alpha-SMA)-positive cells, and clusters of rabbit anti-glial fibrillary acid protein (GFAP)-positive cells.	Lysine	39-42	glial fibrillary acidic protein	Homo sapiens	233-237
17392473-5	2007	In neurons, acetylation at lysine 40 of alpha-tubulin increases the flux of vesicles and the subsequent release of BDNF.	Lysine	27-33	brain derived neurotrophic factor	Homo sapiens	115-119
17320160-2	2007	The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3).	Lysine	44-50	lysine demethylase 1A	Homo sapiens	75-79
18391193-1	2008	Molecular dynamics and hybrid quantum mechanics/molecular mechanics have been used to investigate the mechanisms of (+)AdoMet methylation of protein-Lys-NH(2) catalyzed by the lysine methyltransferase enzymes: histone lysine monomethyltransferase SET7/9, Rubisco large-subunit dimethyltransferase, viral histone lysine trimethyltransferase, and the Tyr245Phe mutation of SET7/9.	Lysine	149-152	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	371-377
18241826-4	2008	RESULTS: The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively.	Lysine	39-42	leptin receptor	Homo sapiens	34-38
30058881-2	2017	This recessive disease is caused by mutations in ALDH7A1, a gene encoding Antiquitin, an enzyme central to lysine degradation.	Lysine	107-113	aldehyde dehydrogenase 7 family member A1	Homo sapiens	49-56
16953217-6	2007	RIZ1 was shown to associate with promoter regions of IGF-1 and to increase histone H3 lysine 9 methylation using chromatin immunoprecipitation assays.	Lysine	86-92	PR/SET domain 2	Homo sapiens	0-4
18241826-4	2008	RESULTS: The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively.	Lysine	115-118	leptin receptor	Homo sapiens	34-38
18241826-4	2008	RESULTS: The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively.	Lysine	115-118	leptin receptor	Homo sapiens	34-38
28395541-5	2017	The C to G exchange (AAC&gt;AAG) at codon 108 of the beta-globin gene results in the substitution of asparagine by lysine.	Lysine	115-121	N-methylpurine DNA glycosylase	Homo sapiens	28-31
18321066-1	2008	This study investigated the requirement for ubiquitylation of PCNA at lysine 164 during polymerase eta-dependent translesion synthesis (TLS) of site-specific cis-syn cyclobutane thymine dimers (T (wedge)T).	Lysine	70-76	proliferating cell nuclear antigen	Homo sapiens	62-66
20483281-0	2007	Structure and function of sheep hemoglobin Chios: A novel allele at the HBBB locus with two Lys--&gt;Arg substitutions at positions beta66(E10) and beta144(HC1).	Lysine	92-95	hemoglobin subunit beta	Ovis aries	72-76
20483281-4	2007	Sequencing of the beta-globin gene confirmed the variant gene as being an allele of the HBBB locus having the AAG--&gt;AGG and the AAA--&gt;AGA mutations at codons 66 and 144, respectively, both corresponding to the Lys--&gt;Arg substitution.	Lysine	216-219	hemoglobin subunit beta	Ovis aries	88-92
28250719-1	2017	Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions.	Lysine	87-90	somatostatin	Homo sapiens	8-20
18321066-4	2008	CFII supplemented with purified recombinant RPA and PCNA (wild type or K164R, in which lysine was replaced with arginine) was competent for DNA replication and TLS.	Lysine	87-93	replication protein A1	Homo sapiens	44-47
17352736-5	2007	Importantly, cell lines lacking the FANCL or FANCD2 genes, or carrying a "knock-in" mutation of the FancD2 monoubiquitination site (where the Lys 563 residue is changed to Arg), displayed quantitatively identical defects in the repair of I-SceI-induced chromosomal breaks by homologous recombination (HR).	Lysine	142-145	Fanconi anemia complementation group D2	Gallus gallus	100-106
18008394-10	2008	These results suggested that in regenerating liver, enhanced the formation of Gln-Lys bonds catalyzed by TG2 led to reduced DNA synthesis, whereas when ODC produced newly synthesized SPD, the inhibition of Gln-Lys bond production by the preferential formation of protein-SPD bonds led to an increase in DNA synthesis.	Lysine	210-213	ornithine decarboxylase 1	Rattus norvegicus	152-155
17129717-2	2007	"Specificity in the coacervation of tropoelastin: solvent exposed lysines."	Lysine	66-73	elastin	Homo sapiens	36-48
17129717-6	2007	An intermolecular crosslink formed between the lysines at positions 353 of each strand of tropoelastin at the lowest of crosslinker concentrations and was observed in all samples tested, suggesting that this residue forms an important initial contact during coacervation.	Lysine	47-54	elastin	Homo sapiens	90-102
27875302-0	2016	Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue.	Lysine	80-86	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	35-39
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	59-65	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	134-138
18291368-13	2008	Down-regulation of maspin synthesis was also associated with histone H3 dimethylation at lysine 9.	Lysine	89-95	serpin family B member 5	Homo sapiens	19-25
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	59-65	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	158-162
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	101-104	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	134-138
27875302-8	2016	By mass spectrometry, we identified two ubiquitin acceptor lysine residues of which only mutation of Lys-380 in the ETS domain of the FLI1 part abolished EWS-FLI1 ubiquitination and stabilized the protein posttranslationally.	Lysine	101-104	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	158-162
17277772-3	2007	LSD1 interacts with the androgen receptor and promotes androgen-dependent transcription of target genes by ligand-induced demethylation of mono- and dimethylated histone H3 at Lys 9 (H3K9) only.	Lysine	176-179	lysine demethylase 1A	Homo sapiens	0-4
18272573-3	2008	Here we report that MIR1 activity is maximal when either a lysine or cysteine residue is placed approximately 15 amino acids away from the transmembrane domain, whereas MIR2 preferentially targets residues, including cysteines, that are closer to the transmembrane domain.	Lysine	59-65	fibronectin type III and SPRY domain containing 1	Homo sapiens	20-24
17172467-6	2007	In the converse situation, when Gln-476 of NCKX4 was converted to Lys, the corresponding residue in NCKX2, both the K(+) and Ca(2+) affinities were reduced.	Lysine	66-69	solute carrier family 24 member 2	Homo sapiens	100-105
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	17-20	matrix metallopeptidase 9	Homo sapiens	84-110
18272573-4	2008	Thus MIR1 and -2 can distinguish their substrates based on the position of the lysine or cysteine residues, suggesting that these proteins have evolved to target different sets of surface molecules.	Lysine	79-85	fibronectin type III and SPRY domain containing 1	Homo sapiens	5-16
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	17-20	matrix metallopeptidase 9	Homo sapiens	112-117
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	49-52	matrix metallopeptidase 9	Homo sapiens	84-110
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	49-52	matrix metallopeptidase 9	Homo sapiens	112-117
17088057-5	2007	The diphosphate moiety interacts with only one cationic residue, namely Lys171 of EL2, while in other P2Y receptor subtypes three Arg or Lys residues interact with the phosphate chain.	Lysine	72-75	spectrin alpha, erythrocytic 1	Homo sapiens	82-85
18298454-6	2008	Increased expression of zonula occludens-1 was observed by the addition of E. hirae ATCC 9790(T) to TNF-alpha-treated Caco-2 cells, and decreased expression of myosin light chain kinase was observed by the addition of LTA and Pam(3)Cys-Ser-(Lys)(4); this, in turn, led to barrier enforcement.	Lysine	241-244	myosin light chain kinase	Homo sapiens	160-185
16949794-3	2007	Primary sequence analysis indicated that the Rap1GAP2 GoLoco motif contains a lysine (Lys-75), rather than an arginine, at the crucial residue responsible for binding the alpha and beta phosphates of GDP and exerting GDI activity.	Lysine	78-84	RAP1 GTPase activating protein 2	Homo sapiens	45-53
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	181-187	matrix metallopeptidase 9	Homo sapiens	84-110
28192309-1	2016	An oligopeptide: Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys-NH2, cleaved specifically by a matrix metalloproteinase 9 (MMP-9) at the Ser-Leu bond, was labeled on the epsilon-NH2 groups of lysine with donor (5, 6 TAMRA) and acceptor (HiLyte647) dye.	Lysine	181-187	matrix metallopeptidase 9	Homo sapiens	112-117
27658392-4	2016	We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to the consensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked polyubiquitination, predominantly at the lysine 100 residue.	Lysine	199-205	COP1, E3 ubiquitin ligase	Mus musculus	33-37
16949794-3	2007	Primary sequence analysis indicated that the Rap1GAP2 GoLoco motif contains a lysine (Lys-75), rather than an arginine, at the crucial residue responsible for binding the alpha and beta phosphates of GDP and exerting GDI activity.	Lysine	86-89	RAP1 GTPase activating protein 2	Homo sapiens	45-53
18272187-8	2008	We found that group I metabotropic glutamate receptors (mGluRs) contribute to LTP induction because the mGluR1 antagonist LY 367385, or the mGluR5 antagonist MPEP, blocked LTP induction.	Lysine	122-124	glutamate receptor, metabotropic 1	Mus musculus	56-62
17179083-1	2007	In yeast, methylation of histone H3 on lysine 36 (H3-K36) is catalyzed by the NSD1 leukemia oncoprotein homolog Set2.	Lysine	39-45	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	112-116
16862177-3	2007	In current models of the functionally similar Skp1, cullin, F-box (SCF)-E3 ligase, the E3 binds the target protein and the E2 catalyses ubiquitin transfer to lysines in an appropriately positioned domain.	Lysine	158-165	KIT ligand	Homo sapiens	67-70
16862177-6	2007	Only one of these lysines need to be intact for full ubiquitination to occur, analogous to the mechanism of Sic1 ubiquitination by the SCF/Cdc34 complex and further strengthening the functional link between the VHL and SCF-E3 ubiquitin ligases.	Lysine	18-25	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	108-112
16862177-6	2007	Only one of these lysines need to be intact for full ubiquitination to occur, analogous to the mechanism of Sic1 ubiquitination by the SCF/Cdc34 complex and further strengthening the functional link between the VHL and SCF-E3 ubiquitin ligases.	Lysine	18-25	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	139-144
16862177-6	2007	Only one of these lysines need to be intact for full ubiquitination to occur, analogous to the mechanism of Sic1 ubiquitination by the SCF/Cdc34 complex and further strengthening the functional link between the VHL and SCF-E3 ubiquitin ligases.	Lysine	18-25	KIT ligand	Homo sapiens	219-222
27658392-4	2016	We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to the consensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked polyubiquitination, predominantly at the lysine 100 residue.	Lysine	199-205	COP1, E3 ubiquitin ligase	Mus musculus	53-58
27903656-5	2017	Here, we discuss the functions of S. cerevisiae HMO1, an HMGB family protein unique in containing a terminal lysine-rich domain and in stabilizing genomic DNA.	Lysine	109-115	Hmo1p	Saccharomyces cerevisiae S288C	48-52
27903656-8	2017	Notably, HMO1 shares with the mammalian linker histone H1 the ability to stabilize chromatin, as evidenced by the absence of HMO1 creating a more dynamic chromatin environment that is more sensitive to nuclease digestion and in which chromatin-remodeling events associated with DNA double-strand break repair occur faster; such chromatin stabilization requires the lysine-rich extension of HMO1.	Lysine	365-371	Hmo1p	Saccharomyces cerevisiae S288C	9-13
18272187-8	2008	We found that group I metabotropic glutamate receptors (mGluRs) contribute to LTP induction because the mGluR1 antagonist LY 367385, or the mGluR5 antagonist MPEP, blocked LTP induction.	Lysine	122-124	glutamate receptor, metabotropic 1	Mus musculus	104-110
18280177-1	2008	The discovery that mutations in WNK4 [encoding a member of the WNK family - so named because of the unique substitution of cysteine for lysine at a nearly invariant residue within subdomain II of its catalytic core: with no K (lysine)] cause pseudohypoaldosteronism type II, an autosomal dominant form of human hypertension, provided the initial clue that this serine/threonine kinase is a crucial part of a complex renal salt regulatory system.	Lysine	136-142	WNK lysine deficient protein kinase 4	Homo sapiens	32-36
27845772-7	2016	Mechanistically, LINC00511 bound histone methyltransferase enhancer of zeste homolog 2 ((EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3), and acted as a modular scaffold of EZH2/PRC2 complexes, coordinated their localization, and specified the histone modification pattern on the target genes, including p57, and consequently altered NSCLC cell biology.	Lysine	243-249	long intergenic non-protein coding RNA 511	Homo sapiens	17-26
17071614-8	2007	In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)).	Lysine	217-220	C-C motif chemokine receptor 6	Homo sapiens	43-47
17071614-8	2007	In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)).	Lysine	239-242	C-C motif chemokine receptor 6	Homo sapiens	43-47
18280177-1	2008	The discovery that mutations in WNK4 [encoding a member of the WNK family - so named because of the unique substitution of cysteine for lysine at a nearly invariant residue within subdomain II of its catalytic core: with no K (lysine)] cause pseudohypoaldosteronism type II, an autosomal dominant form of human hypertension, provided the initial clue that this serine/threonine kinase is a crucial part of a complex renal salt regulatory system.	Lysine	227-233	WNK lysine deficient protein kinase 4	Homo sapiens	32-36
18086528-1	2008	Homoisocitrate dehydrogenase is involved in the alpha-aminoadipate pathway of L-lysine biosynthesis in higher fungi such as yeast and human pathogenic fungi.	Lysine	78-86	homoisocitrate dehydrogenase	Saccharomyces cerevisiae S288C	0-28
17202337-6	2007	The lysine residue in the transmembrane region of MAIR-II was involved in the association with FcRgamma chain as well as DAP12.	Lysine	4-10	TYRO protein tyrosine kinase binding protein	Mus musculus	121-126
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	82-88	sirtuin 1	Homo sapiens	13-18
17098745-4	2007	Furthermore, SIRT1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (Lys-64 and -70) on Smad7.	Lysine	99-102	sirtuin 1	Homo sapiens	13-18
27768322-3	2016	In our previous study, we identified a peptide Ala-Pro-Asp-Thr-Lys-Thr-Gln (APDTKTQ) that can selectively bind to the receptor of advanced glycation end-products (RAGE), an immunoglobulin superfamily cell surface molecule overexpressed during HCC malignant progression.	Lysine	63-66	advanced glycosylation end-product specific receptor	Homo sapiens	118-161
27768322-3	2016	In our previous study, we identified a peptide Ala-Pro-Asp-Thr-Lys-Thr-Gln (APDTKTQ) that can selectively bind to the receptor of advanced glycation end-products (RAGE), an immunoglobulin superfamily cell surface molecule overexpressed during HCC malignant progression.	Lysine	63-66	advanced glycosylation end-product specific receptor	Homo sapiens	163-167
27542907-9	2016	We also observed that two TSC2 lysine mutants in its N-terminal domain, derived from TSC patients, differentially modulate mTORC1 signaling.	Lysine	31-37	TSC complex subunit 2	Homo sapiens	26-30
18322206-2	2008	This regulatory mechanism is usually described by mutually exclusive interactions of KIR2DL1 with C2 having lysine 80, and KIR2DL2/3 with C1 having asparagine 80.	Lysine	108-114	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	85-92
27638829-0	2016	Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.	Lysine	11-17	tripartite motif containing 24	Homo sapiens	61-67
27638829-1	2016	Acetylated H3 lysine 23 (H3K23ac) is a specific histone post-translational modification recognized by oncoprotein TRIM24.	Lysine	14-20	tripartite motif containing 24	Homo sapiens	114-120
16963840-6	2007	We show that ATG7, ATG10 and ATP as an energy source are all essential for ATG12-ATG5 conjugation, and mutation of the specific lysine residue of ATG5 for ATG12 conjugation abrogates the reaction.	Lysine	128-134	autophagy related 10	Homo sapiens	19-24
18242854-5	2008	K354Q substitutes glutamine for an evolutionarily conserved lysine residue in the pore domain of SCN3A.	Lysine	60-66	sodium voltage-gated channel alpha subunit 3	Homo sapiens	97-102
17054919-3	2007	Here, the enzyme-resistant mono-PEGylated GLP-1 isomers substituted at Lys(26)- or Lys(34)-amine were prepared through a newly devised site-specific PEGylation process using a maleic anhydride-protection/deprotection method.	Lysine	71-74	glucagon	Rattus norvegicus	42-47
17054919-3	2007	Here, the enzyme-resistant mono-PEGylated GLP-1 isomers substituted at Lys(26)- or Lys(34)-amine were prepared through a newly devised site-specific PEGylation process using a maleic anhydride-protection/deprotection method.	Lysine	83-86	glucagon	Rattus norvegicus	42-47
17054919-4	2007	The therapeutic potentials of these site-specific PEGylated GLP-1 isomers (Lys(26)- or Lys(34)-PEG-GLP-1) along with His(7)-(N-terminus) PEG-GLP-1 were evaluated by examining their insulinotropic activity, glucose-stabilizing capability, and proteolytic stability.	Lysine	75-78	glucagon	Rattus norvegicus	60-65
17054919-4	2007	The therapeutic potentials of these site-specific PEGylated GLP-1 isomers (Lys(26)- or Lys(34)-PEG-GLP-1) along with His(7)-(N-terminus) PEG-GLP-1 were evaluated by examining their insulinotropic activity, glucose-stabilizing capability, and proteolytic stability.	Lysine	87-90	glucagon	Rattus norvegicus	60-65
17054919-5	2007	Lys(34)-PEG-GLP-1 was found to have the well-preserved insulinotropic activity (93% efficacy versus GLP-1) in isolated rat pancreatic islets.	Lysine	0-3	glucagon	Rattus norvegicus	12-17
17054919-7	2007	Additionally, Lys(34)-PEG-GLP-1 had longer half-lives than the other PEGylated GLP-1s in the dipeptidyl peptidase IV (DPP IV) inhibitor-treated liver or kidney homogenate, and its stability against DPP IV was also comparable to that of Lys(26)-PEG-GLP-1.	Lysine	14-17	glucagon	Rattus norvegicus	26-31
17054919-7	2007	Additionally, Lys(34)-PEG-GLP-1 had longer half-lives than the other PEGylated GLP-1s in the dipeptidyl peptidase IV (DPP IV) inhibitor-treated liver or kidney homogenate, and its stability against DPP IV was also comparable to that of Lys(26)-PEG-GLP-1.	Lysine	236-239	glucagon	Rattus norvegicus	26-31
17054919-8	2007	Taken together, Lys(34)-PEG-GLP-1 displayed the promising characteristics in all evaluations versus His(7)- or Lys(26)-PEG-GLP-1.	Lysine	16-19	glucagon	Rattus norvegicus	28-33
27783945-5	2016	We show that SIRT2 deacetylates Slug protein at lysine residue K116 to prevent Slug degradation.	Lysine	48-54	snail family transcriptional repressor 2	Homo sapiens	32-36
27783945-5	2016	We show that SIRT2 deacetylates Slug protein at lysine residue K116 to prevent Slug degradation.	Lysine	48-54	snail family transcriptional repressor 2	Homo sapiens	79-83
27783950-1	2016	The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2.	Lysine	52-58	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	114-118
18065446-12	2008	CONCLUSION: We conclude that lysine at position 1620 leads to both loss-of-function and gain-of-function properties in hNav1.5 channels, which may consequently cause in the same individuals impaired impulse propagation in the conduction system and prolonged QTc intervals, respectively.	Lysine	29-35	sodium voltage-gated channel alpha subunit 5	Homo sapiens	119-126
27751231-3	2016	We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation.	Lysine	102-108	LDL receptor related protein 6	Homo sapiens	53-57
27751231-4	2016	Subsequent ER exit requires removal of ubiquitin from this lysine by the deubiquitinating enzyme USP19.	Lysine	59-65	ubiquitin specific peptidase 19	Homo sapiens	97-102
18510099-4	2007	IRAK-4 kinase is rendered inactive by mutating the conserved lysine residues in the ATP pocket essential for coordinating ATP.	Lysine	61-67	interleukin-1 receptor-associated kinase 4	Mus musculus	0-6
17068770-3	2007	Recently, PDE has been shown to be caused by a defect of alpha-amino adipic semialdehyde (AASA) dehydrogenase (antiquitin) in the cerebral lysine degradation pathway.	Lysine	139-145	aldehyde dehydrogenase 7 family member A1	Homo sapiens	57-109
18310453-9	2008	Intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in IA-2/IA-2beta KO than control islets.	Lysine	67-73	protein tyrosine phosphatase, receptor type, N	Mus musculus	122-126
17079728-5	2007	To directly address the role of DAT ubiquitylation, lysine residues in DAT were mutated.	Lysine	52-58	solute carrier family 6 member 3	Homo sapiens	71-74
17079728-9	2007	The data are consistent with the model whereby at any given time only one of the lysines in DAT is conjugated with a short ubiquitin chain.	Lysine	81-88	solute carrier family 6 member 3	Homo sapiens	92-95
27582494-3	2016	Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 binding motif of 2 lysine residues separated by about 21 A and mutated the candidate lysine residues to alanine individually and in pairs.	Lysine	146-152	TIMP metallopeptidase inhibitor 3	Homo sapiens	44-50
27582494-3	2016	Here, we used molecular modeling to predict TIMP-3 residues potentially involved in binding to LRP1 based on the proposed LRP1 binding motif of 2 lysine residues separated by about 21 A and mutated the candidate lysine residues to alanine individually and in pairs.	Lysine	212-218	TIMP metallopeptidase inhibitor 3	Homo sapiens	44-50
18070888-5	2008	Mass spectrometry analysis demonstrates that SIAH monoubiquitylates alpha-synuclein at lysines 12, 21, and 23, which were previously shown to be ubiquitylated in Lewy bodies.	Lysine	87-94	synuclein alpha	Homo sapiens	68-83
27647886-0	2016	Structural definition of the lysine swing in Arabidopsis thaliana PDX1: Intermediate channeling facilitating vitamin B6 biosynthesis.	Lysine	29-35	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	66-70
27647886-7	2016	Comparison with the structure of PDX1.3 with an intermediate along the catalytic trajectory demonstrated that a lysine residue swings from the distinct P2 site to the P1 site at this stage of catalysis and is held in place by a molecular catch and pin, positioning it for transfer of serviced substrate back to P2.	Lysine	112-118	Aldolase-type TIM barrel family protein	Arabidopsis thaliana	33-37
17088385-1	2007	A comparative global proteomic screen identified factors required for COMPASS (complex of proteins associated with Set1)-mediated mono-, di-, and trimethylation of the fourth lysine of histone H3 (H3K4), which included components of a cyclin-dependent protein kinase (Ctk complex) that phosphorylates the C-terminal domain of the largest subunit of RNA polymerase II (Pol II).	Lysine	175-181	megakaryocyte-associated tyrosine kinase	Homo sapiens	268-271
17355984-3	2007	Here we show that human cells lacking DNA methyltransferase 1 (Dnmt1), but not Dnmt33b, have a loss of DNA methylation and an increase in the acetylation level of lysine 16 histone H4 at the rRNA genes.	Lysine	163-169	DNA methyltransferase 1	Homo sapiens	38-61
17355984-3	2007	Here we show that human cells lacking DNA methyltransferase 1 (Dnmt1), but not Dnmt33b, have a loss of DNA methylation and an increase in the acetylation level of lysine 16 histone H4 at the rRNA genes.	Lysine	163-169	DNA methyltransferase 1	Homo sapiens	63-68
17355984-4	2007	Interestingly, we observed that SirT1, a NAD+-dependent histone deacetylase with a preference for lysine 16 H4, interacts with Dnmt1; and SirT1 recruitment to the rRNA genes is abrogated in Dnmt1 knockout cells.	Lysine	98-104	sirtuin 1	Homo sapiens	32-37
18192848-9	2008	Acetylation of p53 at the Sirt1-specific lysine 373/382 site was markedly decreased.	Lysine	41-47	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	15-18
17355984-4	2007	Interestingly, we observed that SirT1, a NAD+-dependent histone deacetylase with a preference for lysine 16 H4, interacts with Dnmt1; and SirT1 recruitment to the rRNA genes is abrogated in Dnmt1 knockout cells.	Lysine	98-104	DNA methyltransferase 1	Homo sapiens	127-132
17355984-4	2007	Interestingly, we observed that SirT1, a NAD+-dependent histone deacetylase with a preference for lysine 16 H4, interacts with Dnmt1; and SirT1 recruitment to the rRNA genes is abrogated in Dnmt1 knockout cells.	Lysine	98-104	DNA methyltransferase 1	Homo sapiens	190-195
17189186-3	2006	Here, we show that Tip60 is required for both cell growth arrest and apoptosis mediated by p53 and also induces its acetylation specifically at lysine 120 (K120) within the DNA-binding domain.	Lysine	144-150	lysine acetyltransferase 5	Homo sapiens	19-24
17158804-7	2006	Deletion of this short YY1 motif did not affect transient transcriptional repression but ablated PcG repression, PcG protein recruitment to DNA, and methylation of H3 lysine 27.	Lysine	167-173	pleiohomeotic	Drosophila melanogaster	23-26
27176741-0	2016	Insights into K-Ras 4B regulation by post-translational lysine acetylation.	Lysine	56-62	KRAS proto-oncogene, GTPase	Homo sapiens	14-22
27176741-3	2016	Recently, it has been shown that K-Ras 4B is targeted by lysine acetylation at K104.	Lysine	57-63	KRAS proto-oncogene, GTPase	Homo sapiens	33-41
27180175-1	2016	BACKGROUND: This study aimed to investigate the prolyl and lysine hydroxylation in elastin from different species and tissues.	Lysine	59-65	elastin	Homo sapiens	83-90
17056597-5	2006	The synthetic TLR4 peptide corresponding to the TLR4 region Glu(24)-Lys(47) directly binds to recombinant soluble MD-2 (sMD-2).	Lysine	68-71	lymphocyte antigen 96	Homo sapiens	114-118
18067580-2	2008	Hypusine is formed by post-translational modification of one specific lysine (Lys50 for human eIF5A) by deoxyhypusine synthase and deoxyhypusine hydroxylase.	Lysine	70-76	eukaryotic translation initiation factor 5A	Homo sapiens	94-99
17056597-9	2006	These results demonstrate that the TLR4 region Glu(24)-Lys(47) is a site for MD-2 binding and that Cys(29) and Cys(40) within this region are critical residues for MD-2 binding and LPS signaling.	Lysine	55-58	lymphocyte antigen 96	Homo sapiens	77-81
17056597-9	2006	These results demonstrate that the TLR4 region Glu(24)-Lys(47) is a site for MD-2 binding and that Cys(29) and Cys(40) within this region are critical residues for MD-2 binding and LPS signaling.	Lysine	55-58	lymphocyte antigen 96	Homo sapiens	164-168
18067580-2	2008	Hypusine is formed by post-translational modification of one specific lysine (Lys50 for human eIF5A) by deoxyhypusine synthase and deoxyhypusine hydroxylase.	Lysine	70-76	deoxyhypusine hydroxylase	Homo sapiens	131-156
17167091-8	2006	Carboxypeptidase B treatment decreased cell-dependent plasminogen activation by approximately 90%, suggesting that the binding of plasminogen to proteins exposing C-terminal lysines on the cell surface is required to promote plasminogen activation.	Lysine	174-181	carboxypeptidase B1	Homo sapiens	0-18
17976637-5	2008	Here we report that a phage-displayed repertoire of rearranged antibody genes from splenic B cells from a patient with systemic lupus contain Fab fragments that can bind native acetylated lysine 8 histone H4.	Lysine	188-194	FA complementation group B	Homo sapiens	142-145
17167091-10	2006	Two major plasminogen-binding proteins that exposed C-terminal lysines on the cell surface contained amino acid sequences corresponding to beta/gamma-actin.	Lysine	63-70	POTE ankyrin domain family member F	Homo sapiens	139-155
16951055-5	2006	The CMT3 pathway depends on histone H3 lysine 9 methylation (H3 mK9) to guide DNA methylation.	Lysine	39-45	chromomethylase 3	Arabidopsis thaliana	4-8
16951055-5	2006	The CMT3 pathway depends on histone H3 lysine 9 methylation (H3 mK9) to guide DNA methylation.	Lysine	39-45	keratin 9	Mus musculus	64-67
27898878-6	2016	Results indicated that 1.09% SID Lys was needed to optimize ADG and G:F. In Exp.	Lysine	33-36	ADG	Sus scrofa	60-63
27898878-17	2016	In both types of diets, ADG and G:F linearly and quadratically ( &lt; 0.05) increased as the Thr:Lys ratio increased.	Lysine	97-100	ADG	Sus scrofa	24-27
27898878-18	2016	Regression analysis estimated the ideal SID Thr:Lys ratio at 0.66 and 0.63 for ADG and G:F, respectively, for pigs fed low-fiber diets and at 0.71 and 0.63, respectively, for pigs fed high-fiber diets.	Lysine	48-51	ADG	Sus scrofa	79-82
27358110-3	2016	Here, deacetylation of the Stat5a coactivator and chromatin-remodeling protein HMGN2 on lysine residue K2 by HDAC6 promotes Stat5a-mediated transcription and breast cancer growth.	Lysine	88-94	high mobility group nucleosomal binding domain 2	Homo sapiens	79-84
16980402-2	2006	We show that cre-Lox-mediated excision of 21 kb from both Xist alleles in female mouse fibroblasts led to the appearance of two histone modifications throughout the inactive X chromosome usually associated with euchromatin: histone H4 acetylation and histone H3 lysine-4 methylation.	Lysine	262-268	inactive X specific transcripts	Mus musculus	58-62
18178771-5	2008	All four Uev1 proteins can form a stable complex with At Ubc13 or with Ubc13 from yeast or human and can promote Ubc13-mediated Lys-63 polyubiquitination.	Lysine	128-131	ubiquitin conjugating enzyme E2 N	Homo sapiens	71-76
16923962-4	2006	SIRT1 binds and deacetylates the AR at a conserved lysine motif.	Lysine	51-57	sirtuin 1	Homo sapiens	0-5
27419650-1	2016	We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls.	Lysine	156-162	brain derived neurotrophic factor	Homo sapiens	77-81
27419650-1	2016	We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls.	Lysine	156-162	brain derived neurotrophic factor	Homo sapiens	83-116
16923962-5	2006	Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.	Lysine	127-133	sirtuin 1	Homo sapiens	6-11
16923962-5	2006	Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.	Lysine	127-133	sirtuin 1	Homo sapiens	13-19
18158901-5	2007	In contrast, 53BP1 functions in XRCC4-dependent nonhomologous end-joining, likely mediated by its interaction with dimethylated lysine 20 of histone H4 but, surprisingly, independent of H2AX.	Lysine	128-134	tumor protein p53 binding protein 1	Homo sapiens	13-18
16923962-5	2006	Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.	Lysine	127-133	sirtuin 1	Homo sapiens	14-19
16840712-1	2006	Lysine residues near each end of the receptor ectodomain (in rat P2X2 Lys69 and Lys308) have been implicated in ATP binding to P2X receptors.	Lysine	0-6	purinergic receptor P2X 2	Rattus norvegicus	65-69
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	39-45	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	13-21
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	39-45	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	74-82
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	39-45	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	74-82
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	178-185	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	13-21
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	178-185	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	74-82
27457618-3	2016	We show that MTPalpha is acetylated at lysine residues 350, 383, and 406 (MTPalpha-3K), which promotes its protein stability by antagonizing its ubiquitylation on the same three lysines (MTPalpha-3K) and blocking its subsequent degradation.	Lysine	178-185	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	74-82
16982742-0	2006	Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.	Lysine	47-53	euchromatic histone lysine methyltransferase 2	Homo sapiens	90-93
17997413-8	2007	The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.	Lysine	72-78	embryonic ectoderm development	Mus musculus	34-37
16953299-0	2006	Six specific lysine residues are crucial in maintaining the structure and function of soluble manganese stabilizing protein.	Lysine	13-19	microseminoprotein beta	Homo sapiens	94-123
16953299-6	2006	Both far-ultraviolet circular dichroism and intrinsic fluorescence spectra analysis revealed a clear conformational change in MSP after 4 mM NSP treatment, suggesting that some Lys residues are involved in maintaining the structure and function of MSP.	Lysine	177-180	microseminoprotein beta	Homo sapiens	126-129
16953299-6	2006	Both far-ultraviolet circular dichroism and intrinsic fluorescence spectra analysis revealed a clear conformational change in MSP after 4 mM NSP treatment, suggesting that some Lys residues are involved in maintaining the structure and function of MSP.	Lysine	177-180	microseminoprotein beta	Homo sapiens	248-251
16953299-8	2006	Therefore, these six Lys residues are crucial in maintaining the structure and function of soluble MSP.	Lysine	21-24	microseminoprotein beta	Homo sapiens	99-102
17923681-0	2007	Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.	Lysine	60-66	sirtuin 1	Mus musculus	10-14
27489104-4	2016	The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.	Lysine	19-22	lipocalin 2	Homo sapiens	113-117
17923681-0	2007	Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.	Lysine	60-66	sirtuin 3	Mus musculus	23-28
27489104-4	2016	The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.	Lysine	31-34	lipocalin 2	Homo sapiens	113-117
17923681-9	2007	Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle.	Lysine	50-56	sirtuin 3	Mus musculus	116-121
27489104-4	2016	The basic residues Lys-717 and Lys-719 in the C-terminal region of ANK7 contribute to IkappaBzeta binding to the Lcn2 promoter, probably via interaction with the cytosine-rich element required for Lcn2 activation; glutamate substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta with p50.	Lysine	246-253	lipocalin 2	Homo sapiens	113-117
16887979-10	2006	WT-Spi-C pro-B cells have reduced levels of dimethylation on lysine 9 of histone H3 within the IgH 3" regulatory region, indicating that Spi-C can contribute to removal of repressive features in the IgH locus.	Lysine	61-67	Spi-C transcription factor	Homo sapiens	0-8
16887979-10	2006	WT-Spi-C pro-B cells have reduced levels of dimethylation on lysine 9 of histone H3 within the IgH 3" regulatory region, indicating that Spi-C can contribute to removal of repressive features in the IgH locus.	Lysine	61-67	Spi-C transcription factor	Homo sapiens	3-8
17923681-9	2007	Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle.	Lysine	156-162	sirtuin 3	Mus musculus	116-121
18085999-7	2007	ERCC2 genotype distribution was Lys/Lys 49%, Lys/Gln 44%, Gln/Gln 7%.	Lysine	32-35	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-5
16757531-7	2006	RESULTS: We found a heterozygous G3148--&gt;A nucleotide substitution in the IGF1R gene, changing a negatively charged glutamic acid at position 1050 into a positively charged lysine residue (E1050K).	Lysine	176-182	insulin like growth factor 1 receptor	Homo sapiens	77-82
27653692-4	2016	KAT6A-deficient CD8(+) T cells downregulated surface CD8 co-receptor expression during clonal expansion, a finding linked to reduced Cd8alpha transcripts and histone-H3 lysine 9 acetylation of the Cd8 locus.	Lysine	169-175	CD8a molecule	Homo sapiens	16-19
18085999-7	2007	ERCC2 genotype distribution was Lys/Lys 49%, Lys/Gln 44%, Gln/Gln 7%.	Lysine	36-39	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-5
27470585-4	2016	Overexpression of GFP-LC3 in 3T3-L1 preadipocytes using poly-l-lysine-assisted adenoviral GFP-LC3 transduction was sufficient to produce intracellular lipid droplets.	Lysine	56-69	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	22-25
18085999-7	2007	ERCC2 genotype distribution was Lys/Lys 49%, Lys/Gln 44%, Gln/Gln 7%.	Lysine	36-39	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-5
27470585-4	2016	Overexpression of GFP-LC3 in 3T3-L1 preadipocytes using poly-l-lysine-assisted adenoviral GFP-LC3 transduction was sufficient to produce intracellular lipid droplets.	Lysine	56-69	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	94-97
27470585-7	2016	Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin.	Lysine	223-236	phosphatidylethanolamine binding protein 1	Homo sapiens	25-54
16858404-1	2006	Suv39h1 is a histone H3 lysine-9 (H3-K9) specific methyltransferase (HMT) that is associated with gene silencing through chromatin modification.	Lysine	24-30	histamine N-methyltransferase	Homo sapiens	69-72
27470585-7	2016	Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin.	Lysine	223-236	phosphatidylethanolamine binding protein 1	Homo sapiens	56-60
27470585-7	2016	Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin.	Lysine	223-236	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	261-264
17901049-7	2007	Mutations of four lysine residues to alanine in IRS-2 protein, on the other hand, led to its reduced basal level acetylation and insulin-induced tyrosine phosphorylation.	Lysine	18-24	insulin receptor substrate 2	Homo sapiens	48-53
16702225-4	2006	These studies reveal that binding of a pY peptide to the N-SH2 domain of SHP-2 is greatly enhanced by a large hydrophobic residue (Trp, Tyr, Met, or Phe) at the pY+4 and/or pY+5 positions, whereas binding to SHP-1 N-SH2 domain is enhanced by either hydrophobic or positively charged residues (Arg, Lys, or His) at these positions.	Lysine	298-301	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	73-78
16732292-3	2006	Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain.	Lysine	151-157	malic enzyme 3	Homo sapiens	97-100
16732292-6	2006	So far, all characterized histone demethylases show enzymatic activity towards lysine residues modified in the me1 or me2 state, leaving open the possibility that me3 constitutes an irreversible modification.	Lysine	79-85	malic enzyme 1	Homo sapiens	111-114
27470515-7	2016	Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells.	Lysine	10-16	ATP binding cassette subfamily A member 1	Homo sapiens	113-118
17948050-6	2007	TRAF6 associates with Malt1 in response to T-cell activation and can function as an E3 ligase for Malt1 in vitro and in vivo, mediating lysine 63-linked ubiquitination of Malt1.	Lysine	136-142	TNF receptor associated factor 6	Homo sapiens	0-5
16732292-6	2006	So far, all characterized histone demethylases show enzymatic activity towards lysine residues modified in the me1 or me2 state, leaving open the possibility that me3 constitutes an irreversible modification.	Lysine	79-85	malic enzyme 3	Homo sapiens	163-166
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	168-174	lysine demethylase 4A	Homo sapiens	25-31
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	168-174	lysine demethylase 4A	Homo sapiens	106-112
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Lysine	18-21	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	40-43
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	168-174	malic enzyme 3	Homo sapiens	141-144
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	191-197	lysine demethylase 4A	Homo sapiens	25-31
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	191-197	lysine demethylase 4A	Homo sapiens	106-112
16732292-7	2006	Here we demonstrate that JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable of removing the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36).	Lysine	191-197	malic enzyme 3	Homo sapiens	141-144
16732293-0	2006	The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.	Lysine	63-69	lysine demethylase 4C	Homo sapiens	22-27
27843805-6	2016	RESULTS: TR is modified by SUMO proteins at defined residues: the isoform TRalpha is mainly modified at lysines 281 and 387, whereas lysines 50 and 443 are major SUMOylation sites of isoform TRbeta.	Lysine	104-111	T cell receptor alpha locus	Homo sapiens	74-81
27843805-7	2016	Lysine residues K281 (TRalpha) and K50 (TRbeta) are isoform-specific SUMOylation sites influencing differing TR domains, whereas K387 (TRalpha) and K443 (TRbeta) are orthologous residues.	Lysine	0-6	T cell receptor alpha locus	Homo sapiens	22-29
27843805-7	2016	Lysine residues K281 (TRalpha) and K50 (TRbeta) are isoform-specific SUMOylation sites influencing differing TR domains, whereas K387 (TRalpha) and K443 (TRbeta) are orthologous residues.	Lysine	0-6	T cell receptor alpha locus	Homo sapiens	135-142
27466182-1	2016	SHOC2 is a scaffold protein composed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and glutamate/aspartate residues (KEKE motifs).	Lysine	140-146	SHOC2 leucine rich repeat scaffold protein	Homo sapiens	0-5
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Lysine	22-25	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	40-43
16728977-5	2006	Here we report a 2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethylated at lysine 4.	Lysine	127-133	inhibitor of growth family, member 2	Mus musculus	57-61
16728977-7	2006	The trimethylammonium group of Lys 4 is recognized by the aromatic side chains of Y215 and W238 residues, whereas the intermolecular hydrogen-bonding and complementary surface interactions, involving Ala 1, Arg 2, Thr 3 and Thr 6 of the peptide, account for the PHD finger"s high specificity and affinity.	Lysine	31-34	lymphocyte antigen 6 complex	Mus musculus	200-205
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Lysine	22-25	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	40-43
16728977-7	2006	The trimethylammonium group of Lys 4 is recognized by the aromatic side chains of Y215 and W238 residues, whereas the intermolecular hydrogen-bonding and complementary surface interactions, involving Ala 1, Arg 2, Thr 3 and Thr 6 of the peptide, account for the PHD finger"s high specificity and affinity.	Lysine	31-34	arginase type II	Mus musculus	207-212
27281824-3	2016	The ING3 tumor suppressor protein contains a plant homeodomain (PHD) that reads the epigenetic code via recognition of histone H3 tri-methylated at lysine 4 (H3K4me3), and this domain is lost or mutated in various human cancers.	Lysine	148-154	inhibitor of growth family member 3	Homo sapiens	4-8
16790548-5	2006	Site-specific acetylation of mouse AceCS1 on Lys-661 was identified by using mass spectrometry and a specific anti-acetyl-AceCS antibody.	Lysine	45-48	acyl-CoA synthetase short-chain family member 2	Mus musculus	35-41
17957188-2	2007	The MLL gene encodes a DNA-binding protein that methylates histone H3 lysine 4 (H3K4), and positively regulates gene expression including multiple Hox genes.	Lysine	70-76	lysine methyltransferase 2A	Homo sapiens	4-7
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	chemokine (C-C motif) ligand 2	Mus musculus	180-184
16510838-4	2006	When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser-(Lys)4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls.	Lysine	88-92	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	244-248
27325695-5	2016	Point mutations identified two amino acids (Lys-98 and Asp-100 in LRRC8A and equivalent residues in LRRC8C and -E), which upon charge reversal strongly altered the kinetics and voltage dependence of inactivation.	Lysine	44-47	leucine rich repeat containing 8 VRAC subunit C	Homo sapiens	100-113
17823124-5	2007	Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.	Lysine	173-176	TANK binding kinase 1	Homo sapiens	148-152
17823124-5	2007	Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.	Lysine	173-176	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	153-163
27501389-4	2016	Surprisingly, despite our presumptions, we found that Ubc9 fused to TTR was SUMOylated at a unique set of lysine residues.	Lysine	106-112	transthyretin	Homo sapiens	68-71
27501389-7	2016	SUMOylation of the lysine residues of TTR fused to Ubc9 was hardly detectable.	Lysine	19-25	transthyretin	Homo sapiens	38-41
16785530-7	2006	Indeed, forced expression of c-MIR in several B cell lines down-regulated the surface expression of MHC II, and down-regulation was found to depend on the presence of a single lysine residue in the cytoplasmic tail of the I-A beta-chain.	Lysine	176-182	membrane associated ring-CH-type finger 8	Homo sapiens	29-34
17823124-5	2007	Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.	Lysine	173-176	TANK binding kinase 1	Homo sapiens	148-152
16785530-8	2006	In a reconstitution system using 293T cells, we found that the lysine residue at position 225 in the I-A beta-chain was ubiquitinated by c-MIR.	Lysine	63-69	membrane associated ring-CH-type finger 8	Homo sapiens	137-142
17823124-5	2007	Interestingly, TANK is heavily phosphorylated by TBK1-IKKepsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKepsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKKepsilon kinase activity.	Lysine	173-176	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	153-163
27337507-7	2016	For mitochondrial preparing, SESN2 facilitates the perinuclear-clustering of mitochondria by mediating aggregation of SQSTM1 (sequestosome 1) and its binding to lysine 63 (Lys63)-linked ubiquitins on the mitochondrial surface.	Lysine	161-167	sestrin 2	Mus musculus	29-34
17925448-4	2007	Of the four genes identified, three, SET1, SWD1, and SWD3, encode components of the Set1 complex, which catalyzes the methylation of histone H3 on lysine 4 (H3-K4), a highly conserved modification that occurs in the coding sequences of transcribed genes.	Lysine	147-153	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	37-41
16684606-1	2006	Sirtuins (Sir2-related enzymes) are a recently discovered class of NAD(+)-dependent protein deacetylases that regulate gene expression in a variety of organisms by deacetylation of modified lysine residues on histones, transcription factors and other proteins.	Lysine	190-196	sirtuin 1	Homo sapiens	10-14
26866626-7	2016	However, SOD2-specific activity decreased with age due to elevated posttranslational lysine acetylation.	Lysine	85-91	superoxide dismutase 2	Rattus norvegicus	9-13
17925448-4	2007	Of the four genes identified, three, SET1, SWD1, and SWD3, encode components of the Set1 complex, which catalyzes the methylation of histone H3 on lysine 4 (H3-K4), a highly conserved modification that occurs in the coding sequences of transcribed genes.	Lysine	147-153	COMPASS subunit protein SWD1	Saccharomyces cerevisiae S288C	43-47
16608845-4	2006	The results showed that Asp-122, Lys-191, Lys-225, Lys-256, Glu-261, and Lys-312,Lys-313 residues of rat Asbt are critical for transport function and may determine substrate specificity.	Lysine	33-36	solute carrier family 10 member 2	Rattus norvegicus	105-109
16608845-4	2006	The results showed that Asp-122, Lys-191, Lys-225, Lys-256, Glu-261, and Lys-312,Lys-313 residues of rat Asbt are critical for transport function and may determine substrate specificity.	Lysine	42-45	solute carrier family 10 member 2	Rattus norvegicus	105-109
17925448-4	2007	Of the four genes identified, three, SET1, SWD1, and SWD3, encode components of the Set1 complex, which catalyzes the methylation of histone H3 on lysine 4 (H3-K4), a highly conserved modification that occurs in the coding sequences of transcribed genes.	Lysine	147-153	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	84-88
16608845-4	2006	The results showed that Asp-122, Lys-191, Lys-225, Lys-256, Glu-261, and Lys-312,Lys-313 residues of rat Asbt are critical for transport function and may determine substrate specificity.	Lysine	42-45	solute carrier family 10 member 2	Rattus norvegicus	105-109
17681795-12	2007	Previously we developed a new type of peptide blocker with much enhanced affinity for DQ2 by dimerizing LQLQPFPQPEKPYPQPELPY through the lysine side chains.	Lysine	137-143	torsin family 1 member A	Homo sapiens	86-89
16800733-6	2006	All synthetic substrates tested containing either arginine or lysine at P1 position were cleaved by hK8.	Lysine	62-68	keratin 8	Homo sapiens	100-103
27343629-1	2016	G9a is one of the histone H3 Lys 9 (H3K9) specific methyltransferases first identified in mammals.	Lysine	29-32	G9a	Drosophila melanogaster	0-3
27356773-7	2016	Mass spectrometry analysis of aspirin-acetylated G6PD (isoform a) revealed that aspirin acetylated a total of 14 lysine residues, which were dispersed throughout the length of the G6PD protein.	Lysine	113-119	glucose-6-phosphate dehydrogenase	Homo sapiens	49-53
17909057-11	2007	This correlates with inhibition of nonproteasomal (Lys-63) ubiquitylation of TRAF6, which is essential to IkappaB kinase activation.	Lysine	51-54	TNF receptor associated factor 6	Homo sapiens	77-82
27356773-7	2016	Mass spectrometry analysis of aspirin-acetylated G6PD (isoform a) revealed that aspirin acetylated a total of 14 lysine residues, which were dispersed throughout the length of the G6PD protein.	Lysine	113-119	glucose-6-phosphate dehydrogenase	Homo sapiens	180-184
27486435-9	2016	The amount of MRAP was increased by the proteasome inhibitor MG132 and MRAP underwent ubiquitylation on lysine and other amino acids.	Lysine	104-110	melanocortin-2 receptor accessory protein	Cricetulus griseus	14-18
27486435-9	2016	The amount of MRAP was increased by the proteasome inhibitor MG132 and MRAP underwent ubiquitylation on lysine and other amino acids.	Lysine	104-110	melanocortin-2 receptor accessory protein	Cricetulus griseus	71-75
16858129-3	2006	The Thr(201)Lys and Met(260)Val also presented together with known SNPs (Glu(158)Lys-Glu(308)Gly and Val(257)Met, respectively) in the same alleles of the FMO3 gene to form novel haplotypes.	Lysine	12-15	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	155-159
16627621-0	2006	Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis.	Lysine	50-56	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	18-22
17670833-5	2007	A proportion of the enlarged ND10-like foci in quiescently infected cells contain accumulations of the heterochromatin protein HP1 but not other common markers of heterochromatin such as histone H3 di- or trimethylated on lysine residue 9.	Lysine	222-228	chromobox 5	Homo sapiens	127-130
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Lysine	20-23	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	30-34
16455067-1	2006	BACKGROUND: The G to A mutation in the Kir 6.2, the ATP-sensitive potassium channel subunit, resulted a glutamate (E) to lysine (K) substitution at codon 23, and the A allele was shown to have a relationship with high risk to type 2 diabetes in previous study.	Lysine	121-127	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	39-46
27486435-10	2016	Nonetheless, when protein synthesis was blocked with cycloheximide, MRAP was rapidly degraded even when MG132 was included and all lysines were replaced by arginines, implicating non-proteasomal degradation pathways.	Lysine	131-138	melanocortin-2 receptor accessory protein	Cricetulus griseus	68-72
17709386-1	2007	Treatment of Saccharomyces cerevisiae cells with DNA-damaging agents elicits lysine 164-linked PCNA monoubiquitination by Rad6-Rad18.	Lysine	77-83	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	122-126
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	syntaxin 5	Homo sapiens	0-4
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	syntaxin 5	Homo sapiens	93-97
16648479-3	2006	We systematically mutated the N-terminal domain of histone H2B, both at known sites of lysine acetylation and elsewhere, and characterized the resulting changes in genome-wide expression in each mutant strain.	Lysine	87-93	histone H2B	Saccharomyces cerevisiae S288C	51-62
17645432-3	2007	Through analysis of the trafficking and degradation of Ctr1p mutants, two lysine residues in the C-terminal cytoplasmic tail of Ctr1p, Lys340 and Lys345, were found to be critical for copper-dependent endocytosis and degradation.	Lysine	74-80	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	55-60
16611979-0	2006	Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo.	Lysine	108-114	ubiquitin-specific protease UBP8	Saccharomyces cerevisiae S288C	0-5
27377381-2	2016	Motivated by recent studies identifying a chemically diverse array of lysine acyl modifications in vivo, the acyl-chain specificity of the acetyltransferase human Gcn5 (Gcn5L2) was examined.	Lysine	70-76	lysine acetyltransferase 2A	Homo sapiens	163-167
27377381-3	2016	Whereas Gcn5L2 robustly catalyzes lysine acetylation, the acyltransferase activity of Gcn5L2 becomes progressively weaker with increasing acyl-chain length.	Lysine	34-40	lysine acetyltransferase 2A	Homo sapiens	8-14
17645432-3	2007	Through analysis of the trafficking and degradation of Ctr1p mutants, two lysine residues in the C-terminal cytoplasmic tail of Ctr1p, Lys340 and Lys345, were found to be critical for copper-dependent endocytosis and degradation.	Lysine	74-80	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	128-133
26972532-8	2016	The ratio of regulatory T cells after the administration of MDP-Lys (L18) was significantly decreased in Rnf213-deficient mice (p&lt;0.01), suggesting the potential role of the RNF213 abnormality in the differentiation of regulatory T cells.	Lysine	64-67	ribosomal protein L18	Mus musculus	69-72
16492666-5	2006	We found that the ubiquitin-dependent degradation of Rpn4 can be mediated by six different lysines.	Lysine	91-98	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	53-57
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	24-30	high mobility group AT-hook 1	Homo sapiens	43-49
16594666-1	2006	Histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the oxidative removal of one or two methyl groups from the methyl-lysine-4 side chain of histone H3.	Lysine	142-148	lysine demethylase 1A	Homo sapiens	20-24
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	57-60	high mobility group AT-hook 1	Homo sapiens	43-49
26081144-5	2016	Moreover, kisspeptin specifically induced acetylation of H3AcK14 and K27 and trimethylation of H3 lysine 4 at the KsRE (markers of active chromatin) and no changes in dimethylation of H3K9 (a marker associated with gene repression).	Lysine	98-104	KiSS-1 metastasis-suppressor	Mus musculus	10-20
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	high mobility group AT-hook 1	Homo sapiens	43-49
16213628-6	2006	This unique activity of parkin mediates a non-classical, lysine (K) 63-linked ubiquitin multichain assembly on synphilin-1 that is distinct from the classical, degradation-associated, K48-linked ubiquitination.	Lysine	57-63	synuclein alpha interacting protein	Homo sapiens	111-122
27259994-4	2016	Site-directed mutagenesis revealed that acetylation at lysine (K) 64 of LKB1 triggers the formation of SIRT1/HERC2/LKB1 protein complex and subsequent proteasomal degradation.	Lysine	55-61	sirtuin 1	Homo sapiens	103-108
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	high mobility group AT-hook 1	Homo sapiens	43-49
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	high mobility group AT-hook 1	Homo sapiens	43-49
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	high mobility group AT-hook 1	Homo sapiens	43-49
27315244-3	2016	We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425).	Lysine	147-153	small ubiquitin like modifier 2	Homo sapiens	130-137
16533046-6	2006	As HMO1-boxAB, lacking only the lysine-rich C-terminal segment, exhibits two melting transitions at 46.0 and 63.3 degrees C, we conclude that the destabilization of the box A domain seen in full-length HMO1 is due primarily to its interaction with the lysine-rich tail.	Lysine	252-258	Hmo1p	Saccharomyces cerevisiae S288C	3-7
16533046-6	2006	As HMO1-boxAB, lacking only the lysine-rich C-terminal segment, exhibits two melting transitions at 46.0 and 63.3 degrees C, we conclude that the destabilization of the box A domain seen in full-length HMO1 is due primarily to its interaction with the lysine-rich tail.	Lysine	252-258	Hmo1p	Saccharomyces cerevisiae S288C	202-206
16533046-7	2006	Determination of DNA substrate specificity using electrophoretic mobility shift assays shows unexpectedly that the lysine-rich tail does not increase DNA binding affinity but instead is required for DNA bending by full-length HMO1; HMO1-boxBC, lacking the box A domain, also fails to bend DNA.	Lysine	115-121	Hmo1p	Saccharomyces cerevisiae S288C	226-230
16533046-7	2006	Determination of DNA substrate specificity using electrophoretic mobility shift assays shows unexpectedly that the lysine-rich tail does not increase DNA binding affinity but instead is required for DNA bending by full-length HMO1; HMO1-boxBC, lacking the box A domain, also fails to bend DNA.	Lysine	115-121	Hmo1p	Saccharomyces cerevisiae S288C	232-236
17627840-4	2007	We further quantified the level of acetylation by analyzing, with LC-MS/MS, the proteolytic peptides of the in vitro or in vivo acetylated HMGA1 proteins where the unmodified lysine residues were chemically derivatized with a perdeuterated acetyl group.	Lysine	175-181	high mobility group AT-hook 1	Homo sapiens	139-144
17686003-7	2007	Increased cross-linking of the lysine analogue 5-(biotinamido)pentylamine to cultured OKF6/TERT-2 cell proteins accompanied this increased expression of SPR3.	Lysine	31-37	telomerase reverse transcriptase	Homo sapiens	91-95
16525756-3	2006	The first two enzymes of lysine catabolism are synthesized from a single LKR/SDH gene.	Lysine	25-31	aminoadipate-semialdehyde synthase	Homo sapiens	73-80
27094131-2	2016	Recently, de novo variants have been mapped on the gene encoding for the lysine-specific histone demethylase 1 (LSD1)/lysine(K)-specific histone demethylase 1A in three patients characterized by a new genetic disorder.	Lysine	73-79	lysine demethylase 1A	Homo sapiens	112-116
16250000-0	2006	SCN- binding to the charged lysines of histones end domains mimics acetylation and shows the major histone-DNA interactions involved in eu and heterochromatin stabilization.	Lysine	28-35	sorcin	Homo sapiens	0-3
17691833-8	2007	HTB2 shows similar acetylation and ubiquitination sites and an additional methylation at Lys-11.	Lysine	89-92	histone B2	Arabidopsis thaliana	0-4
16250000-1	2006	SCN- binds to the charged amino group of lysines, inducing local changes in the electrostatic free energy of histones.	Lysine	41-48	sorcin	Homo sapiens	0-3
16319397-9	2006	The main histone H2B variant, H2BA, was acetylated at Lys-12, -15, and -20.	Lysine	54-57	H2B clustered histone 8	Homo sapiens	30-34
27124586-1	2016	The Nepsilon-lysine acetylation of cargo proteins in the lumen of the endoplasmic reticulum (ER) requires a membrane transporter (SLC33A1) and 2 acetyltransferases (NAT8B and NAT8).	Lysine	13-19	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	130-137
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Lysine	23-26	neurofilament heavy chain	Homo sapiens	72-76
26411363-5	2016	We identified two lysine residues located at the inter-SH2 domain on p85beta, a critical region required for inhibition of p110, as being required for SUMO conjugation.	Lysine	18-24	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	69-76
16596166-4	2006	Heretofore, only type I and II HDACs, through deactylation of lysines 9 and 14 of histone H3 (H3-K9 and H3-K14, respectively), had been tied to the above TSG silencing.	Lysine	62-69	twisted gastrulation BMP signaling modulator 1	Homo sapiens	154-157
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Lysine	23-26	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	93-97
27253695-2	2016	We investigated the effects of siRNA-mediated depletion of histone demethylase Jarid1A (KDM5A, RBP2), which demethylates transcription activating tri- and dimethylated lysine 4 at histone H3 (H3K4me3/me2), on growth characteristics and cellular response to radiation in several cancer cell lines.	Lysine	168-174	lysine demethylase 5A	Homo sapiens	88-93
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Lysine	23-26	neurofilament heavy chain	Homo sapiens	111-115
16481475-6	2006	The analysis of Stat1 mutants reveals Lys 410 and Lys 413 as acetylation sites.	Lysine	38-41	signal transducer and activator of transcription 1	Homo sapiens	16-21
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Lysine	23-26	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	153-157
16481475-6	2006	The analysis of Stat1 mutants reveals Lys 410 and Lys 413 as acetylation sites.	Lysine	50-53	signal transducer and activator of transcription 1	Homo sapiens	16-21
17626162-9	2007	Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H.	Lysine	23-26	neurofilament heavy chain	Homo sapiens	111-115
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Lysine	60-66	cationic amino acid transporter	Saccharomyces cerevisiae S288C	0-4
16415856-3	2006	Transcriptional repression is followed by a pronounced increase in histone H3 methylation on Lys 9 that is mediated by the SET-containing protein, G9a.	Lysine	93-96	euchromatic histone lysine methyltransferase 2	Homo sapiens	147-150
17617175-7	2007	Reduction in SAMS expression level leads most probably to the reduction of SAM found in plants that feed with lysine.	Lysine	110-116	S-adenosylmethionine synthase 1	Nicotiana tabacum	13-17
16291740-1	2006	The basal level of the tumor suppressor p53 is regulated by MDM2-mediated ubiquitination at specific lysines, which leads to p53 nuclear export and degradation.	Lysine	101-108	MDM2 proto-oncogene	Homo sapiens	60-64
26676302-7	2016	After 12 h of estradiol exposure, a downregulation of this PR isoform was associated with a decrease of specific protein 1, histone 3 lysine 4 trimethylation, and RNA polymerase II occupancy on PR-B promoter, without changes in DNA methylation and hydroxymethylation.	Lysine	134-140	progesterone receptor	Mus musculus	59-61
17719542-5	2007	In addition, hCAS/CSE1L silencing leads to increased methylation of histone H3 lysine 27 within the PIG3 gene.	Lysine	79-85	chromosome segregation 1 like	Homo sapiens	13-17
26719496-5	2016	The guanine-to-adenine change causes substitution of the normal glutamic acid codon (GAG) with a mutant lysine codon (AAG) at position 312 (E312 K mutation).	Lysine	104-110	N-methylpurine DNA glycosylase	Homo sapiens	118-121
27111035-1	2016	RELATIVE OF EARLY FLOWERING 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl groups from trimethylated histone H3 lysine 27 (H3K27me3) in hundreds of genes in Arabidopsis thaliana.	Lysine	159-165	relative of early flowering 6	Arabidopsis thaliana	0-29
27111035-1	2016	RELATIVE OF EARLY FLOWERING 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl groups from trimethylated histone H3 lysine 27 (H3K27me3) in hundreds of genes in Arabidopsis thaliana.	Lysine	159-165	relative of early flowering 6	Arabidopsis thaliana	31-35
16322686-0	2006	Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.	Lysine	39-45	H4 clustered histone 9	Homo sapiens	28-38
16322686-0	2006	Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.	Lysine	39-45	DNA methyltransferase 1	Homo sapiens	135-158
16322686-6	2006	The decrease in trimethylation of lysine 20 of histone H4 in MDA-MB-231 cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase.	Lysine	34-40	H4 clustered histone 9	Homo sapiens	47-57
17206516-5	2006	Neutralizing either of two lysine residues in the outer vestibule of these Kv2.1 channels conferred ionic strength sensitivity to TEA block.	Lysine	27-33	potassium voltage-gated channel subfamily B member 1	Homo sapiens	75-80
17719542-5	2007	In addition, hCAS/CSE1L silencing leads to increased methylation of histone H3 lysine 27 within the PIG3 gene.	Lysine	79-85	chromosome segregation 1 like	Homo sapiens	18-23
17206516-6	2006	Kv2.1 channels with both lysines neutralized were sensitive to block by gallamine, and the ionic strength dependence of this block was greater than that for TEA.	Lysine	25-32	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
17712411-5	2007	Myc-induced exit from the stem cell niche correlated with increased acetylation at histone H4 and transiently increased mono-methylation at lysine 20.	Lysine	140-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
17206516-8	2006	The presence of specific lysine residues in wild-type Kv2.1 channels produces an outer vestibule with little or no net charge, with important consequences for quaternary ammonium block.	Lysine	25-31	potassium voltage-gated channel subfamily B member 1	Homo sapiens	54-59
27111035-1	2016	RELATIVE OF EARLY FLOWERING 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl groups from trimethylated histone H3 lysine 27 (H3K27me3) in hundreds of genes in Arabidopsis thaliana.	Lysine	159-165	relative of early flowering 6	Arabidopsis thaliana	51-56
17694080-2	2007	Males absent on the first (MOF) is responsible for acetylating histone H4 at lysine 16 (H4K16) and is a key component of the MSL complex required for dosage compensation in Drosophila.	Lysine	77-83	males absent on the first	Drosophila melanogaster	27-30
27109047-4	2016	In the present study, we showed that ERG can directly bind to KDM4A (also known as JMJD2A), a histone demethylase that particularly demethylates lysine 9 on histone H3.	Lysine	145-151	lysine demethylase 4A	Homo sapiens	62-67
27109047-4	2016	In the present study, we showed that ERG can directly bind to KDM4A (also known as JMJD2A), a histone demethylase that particularly demethylates lysine 9 on histone H3.	Lysine	145-151	lysine demethylase 4A	Homo sapiens	83-89
27109047-7	2016	Furthermore, we found that ERG expression reduced histone H3 lysine 9 trimethylation at the YAP1 gene promoter, consistent with its epigenetic regulation through the ERG interaction partner, KDM4A.	Lysine	61-67	lysine demethylase 4A	Homo sapiens	191-196
27109588-6	2016	Furthermore, LSD1 interacted with the promoter of E-cadherin and demethylated histone H3 lysine 4 (H3K4) at this region, downregulated E-cadherin expression, and consequently enhanced ovarian cancer cell migration.	Lysine	89-95	lysine demethylase 1A	Homo sapiens	13-17
16714119-3	2006	The positive charge at physiological pH of Lys/Hyl side chains is preserved only by N-methylation.	Lysine	43-46	megakaryocyte-associated tyrosine kinase	Homo sapiens	47-50
16229820-5	2005	Four out of the 16 isolated Kex2 variants showed greater preference for Met than for Lys (preferred by the wild-type Kex2) at the P2 position.	Lysine	85-88	kexin KEX2	Saccharomyces cerevisiae S288C	28-32
17694090-6	2007	One of the key factors that might have contributed to this preservation is the intimate relationship between some members of this group of proteins (SirT1, SirT2 and SirT3) and deacetylation of a specific residue in histone H4, lysine 16 (H4K16).	Lysine	228-234	sirtuin 2	Homo sapiens	156-161
16229820-5	2005	Four out of the 16 isolated Kex2 variants showed greater preference for Met than for Lys (preferred by the wild-type Kex2) at the P2 position.	Lysine	85-88	kexin KEX2	Saccharomyces cerevisiae S288C	117-121
17687327-0	2007	DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.	Lysine	29-35	DNA methyltransferase 3 like	Homo sapiens	0-6
16260194-4	2005	In yeast, the homolog of DPY-30, Saf19p, functions as a member of histone 3 lysine 4 methylation complex, which is the key part of epigenetic developmental control.	Lysine	76-82	dpy-30 histone methyltransferase complex regulatory subunit	Homo sapiens	25-31
27059868-0	2016	Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation.	Lysine	14-20	lysine demethylase 1A	Homo sapiens	45-49
27059868-0	2016	Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation.	Lysine	14-20	lysine demethylase 1A	Homo sapiens	50-55
17687327-4	2007	Peptide interaction assays showed that DNMT3L specifically interacts with the extreme amino terminus of histone H3; this interaction was strongly inhibited by methylation at lysine 4 of histone H3 but was insensitive to modifications at other positions.	Lysine	174-180	DNA methyltransferase 3 like	Homo sapiens	39-45
16317119-7	2005	Related to this, specific lysine residues were acetylated on histones H3 and H4 at the 3 RAREs of the PEPCK promoter, consistent with the action of the above coactivators, and acetylation of certain lysines was significantly decreased with vitamin A deficiency.	Lysine	26-32	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	102-107
17687327-7	2007	These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2.	Lysine	85-91	DNA methyltransferase 3 like	Homo sapiens	25-31
16317119-7	2005	Related to this, specific lysine residues were acetylated on histones H3 and H4 at the 3 RAREs of the PEPCK promoter, consistent with the action of the above coactivators, and acetylation of certain lysines was significantly decreased with vitamin A deficiency.	Lysine	199-206	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	102-107
27216891-6	2016	Mechanistically, GCN5 regulated DKK1 expression by acetylation of Histone H3 lysine 9 (H3K9) and Histone H3 lysine 14 (H3K14) at its promoter region.	Lysine	77-83	lysine acetyltransferase 2A	Homo sapiens	17-21
27216891-6	2016	Mechanistically, GCN5 regulated DKK1 expression by acetylation of Histone H3 lysine 9 (H3K9) and Histone H3 lysine 14 (H3K14) at its promoter region.	Lysine	108-114	lysine acetyltransferase 2A	Homo sapiens	17-21
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Lysine	57-60	sodium voltage-gated channel alpha subunit 8	Homo sapiens	111-117
16095636-0	2005	Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues.	Lysine	153-159	neurotensin	Rattus norvegicus	88-99
17671180-5	2007	We also found that MTA1 acetylated on Lys(626) interacted with p300 histone acetyltransferase, and that acetylated MTA1 was recruited to the Pax5 promoter to stimulate Pax5 transcription.	Lysine	38-41	metastasis associated 1	Mus musculus	19-23
16274242-0	2005	Thermodynamics and kinetics of formation of the alkaline state of a Lys 79--&gt;Ala/Lys 73--&gt;His variant of iso-1-cytochrome c.	Lysine	68-71	eukaryotic translation initiation factor 1	Homo sapiens	111-116
17671180-5	2007	We also found that MTA1 acetylated on Lys(626) interacted with p300 histone acetyltransferase, and that acetylated MTA1 was recruited to the Pax5 promoter to stimulate Pax5 transcription.	Lysine	38-41	paired box 5	Mus musculus	141-145
16274242-0	2005	Thermodynamics and kinetics of formation of the alkaline state of a Lys 79--&gt;Ala/Lys 73--&gt;His variant of iso-1-cytochrome c.	Lysine	84-87	eukaryotic translation initiation factor 1	Homo sapiens	111-116
16274242-1	2005	The alkaline transition kinetics of a Lys 73--&gt;His (H73) variant of iso-1-cytochrome c are triggered by three ionizable groups [Martinez, R. E., and Bowler, B. E. (2004) J.	Lysine	38-41	eukaryotic translation initiation factor 1	Homo sapiens	71-76
27044868-0	2016	Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.	Lysine	13-19	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	79-85
17671180-5	2007	We also found that MTA1 acetylated on Lys(626) interacted with p300 histone acetyltransferase, and that acetylated MTA1 was recruited to the Pax5 promoter to stimulate Pax5 transcription.	Lysine	38-41	paired box 5	Mus musculus	168-172
17610498-5	2007	Both prokaryotic and eukaryotic elongation TFs (EF1A) are methylated at lysine residues, while both release factors are methylated at glutamine residues.	Lysine	72-78	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	48-52
27181215-4	2016	Immunofluorescence analyses revealed that PRC1 members are co-localized with its functional histone modifier H2AK119ub1 (mono ubiquitination of histone-H2A at lysine-119) in polyploid cell.	Lysine	159-165	H2A.B variant histone 2	Mus musculus	144-155
26951200-5	2016	The PIAS3 binding region in GFI1 contains a conserved type I SUMOylation consensus element, centered on lysine-239 (K239).	Lysine	104-110	growth factor independent 1 transcriptional repressor	Homo sapiens	28-32
16285929-2	2005	We now show that the DM1 insulator is maintained in a local heterochromatin context: an antisense transcript emanating from the adjacent SIX5 regulatory region extends into the insulator element and is converted into 21 nucleotide (nt) fragments with associated regional histone H3 lysine 9 (H3-K9) methylation and HP1gamma recruitment that is embedded within a region of euchromatin-associated H3 lysine 4 (H3-K4) methylation.	Lysine	398-404	SIX homeobox 5	Homo sapiens	137-141
16285960-6	2005	RESULTS: Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 terminus are acetylated by p300.	Lysine	13-16	E1A binding protein p300	Mus musculus	95-99
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	E1A binding protein p300	Mus musculus	97-101
17610210-2	2007	Calmodulin, a key modulator of intracellular calcium signaling, is methylated on lysine 115 in many species.	Lysine	81-87	Calmodulin	Drosophila melanogaster	0-10
16227595-1	2005	Set2p, which mediates histone H3 lysine 36 dimethylation (H3K36me2) in Saccharomyces cerevisiae, has been shown to associate with RNA polymerase II (RNAP II) at individual loci.	Lysine	33-39	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-5
26874701-4	2016	Based on the structure of TLR7/8 ligands, a series of synthetic amino acids 6-imidazoquinolyl-norleucines were synthesized, wherein an imidazoquinoline structure as the TLR7/8 agonistic pharmacophores was constructed on the epsilon-NH2 group of Lys.	Lysine	245-248	toll-like receptor 7	Mus musculus	26-30
26874701-4	2016	Based on the structure of TLR7/8 ligands, a series of synthetic amino acids 6-imidazoquinolyl-norleucines were synthesized, wherein an imidazoquinoline structure as the TLR7/8 agonistic pharmacophores was constructed on the epsilon-NH2 group of Lys.	Lysine	245-248	toll-like receptor 7	Mus musculus	169-173
17610210-3	2007	Although the amino acid sequence of calmodulin is highly conserved in eukaryotes, it has been shown that lysine 115 is not methylated in Drosophila calmodulin and no other methylation site has been reported.	Lysine	105-111	Calmodulin	Drosophila melanogaster	36-46
17610210-6	2007	We identified that lysine 94 located in an EF-hand III is the methylation site in Drosophila calmodulin.	Lysine	19-25	Calmodulin	Drosophila melanogaster	93-103
27038651-4	2016	It was also demonstrated that structural changes caused by Carboxypeptidase B treatment and deamidation study at pH extremes could be sensitively captured with the established method, with the results further indicating that the generic product"s basic variations of Fc/2 were un-cleaved Lysine residues, while the lack of certain acidic peaks on LC and Fd probably was due to the lower level of deamidation.	Lysine	288-294	carboxypeptidase B1	Homo sapiens	59-77
16126721-6	2005	Indeed, we found that conversion of Lys-226 to N(epsilon)-(3-methylpyridinium)lysine by acrolein associated quantitatively with decreased cholesterol efflux from cells via the ATP-binding cassette transporter A1 pathway.	Lysine	36-39	ATP binding cassette subfamily A member 1	Homo sapiens	176-211
18217483-4	2007	hK14 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Lysine	69-72	keratin 14	Homo sapiens	0-4
16220989-3	2005	In this context, it was discovered that a simple octa(l-lysine) peptide covalently linked to the PNA is capable of promoting free uptake of the conjugate into BCL1 cells as well as primary murine macrophages.	Lysine	54-62	cyclin D1	Mus musculus	159-163
26967762-3	2016	Transcriptome analyses coupled with promoter activity measurements and growth phenotype analyses led us to identify new members in l-Lys and d-Lys catabolism and regulation, including gcdR-gcdHG for glutarate utilization, dpkA, amaR-amaAB and PA2035 for d-Lys catabolism, lysR-lysXE for putative l-Lys efflux and lysP for putative l-Lys uptake.	Lysine	131-136	lysine-specific permease	Pseudomonas aeruginosa PAO1	313-317
26967762-3	2016	Transcriptome analyses coupled with promoter activity measurements and growth phenotype analyses led us to identify new members in l-Lys and d-Lys catabolism and regulation, including gcdR-gcdHG for glutarate utilization, dpkA, amaR-amaAB and PA2035 for d-Lys catabolism, lysR-lysXE for putative l-Lys efflux and lysP for putative l-Lys uptake.	Lysine	133-136	lysine-specific permease	Pseudomonas aeruginosa PAO1	313-317
26967762-3	2016	Transcriptome analyses coupled with promoter activity measurements and growth phenotype analyses led us to identify new members in l-Lys and d-Lys catabolism and regulation, including gcdR-gcdHG for glutarate utilization, dpkA, amaR-amaAB and PA2035 for d-Lys catabolism, lysR-lysXE for putative l-Lys efflux and lysP for putative l-Lys uptake.	Lysine	143-146	lysine-specific permease	Pseudomonas aeruginosa PAO1	313-317
17643371-4	2007	Trimethylated histone H3 lysine 9 (H3-K9) was found to associate with the histone trimethyltransferase Suv39h1 and DNA methyltransferase Dnmt3a in the methylated 14-3-3sigma locus.	Lysine	25-31	stratifin	Homo sapiens	162-173
16046620-4	2005	Heterochromatin domains are altered or completely lost in MADA nuclei, consistent with the finding that heterochromatin-associated protein HP1beta and histone H3 methylated at lysine 9 and their nuclear envelope partner protein lamin B receptor (LBR) are delocalized and solubilized.	Lysine	176-182	chromobox 1	Homo sapiens	139-146
17643376-2	2007	We previously studied histone H2B ubiquitylation on lysine 123 and subsequent deubiquitylation by SAGA-associated Ubp8.	Lysine	52-58	H2B clustered histone 21	Homo sapiens	30-33
16195383-7	2005	Moreover, H3 Lys-4 methylation associated with p27 and p18 is reduced in islet tumors from Men1 mutant mice.	Lysine	13-16	cyclin-dependent kinase inhibitor 1B	Mus musculus	47-50
16195383-7	2005	Moreover, H3 Lys-4 methylation associated with p27 and p18 is reduced in islet tumors from Men1 mutant mice.	Lysine	13-16	cyclin dependent kinase inhibitor 2C	Mus musculus	55-58
27032069-0	2016	Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217.	Lysine	65-68	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	58-64
17620408-6	2007	Despite a crucial function of Ring1B in establishing the chromosome-wide ubiquitination of histone H2A lysine 119 (H2AK119ub1) upon Xist expression in ES cells, the initiation of silencing by Xist is independent of Ring1B.	Lysine	103-109	ring finger protein 2	Mus musculus	30-36
26645727-2	2016	Mutations in EED and SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent aberrant transcriptional activation of polycomb repressive complex 2-repressed homeobox master regulators.	Lysine	60-66	embryonic ectoderm development	Homo sapiens	13-16
16154109-8	2005	One of the mutants, in which the position of a tryptophan residue within the TM domain is altered, is known not to induce CD4 degradation; an extended kinked model of this mutant has been generated (Vpu(1-52)IVW-k) and during subsequent MD simulations, the bend between the TM and a part of the cytoplasmic domain is found to unwind and a complex salt bridge involving Lys-37 is formed.	Lysine	369-372	Vpu	Human immunodeficiency virus 1	199-202
17632060-5	2007	These proteins display strikingly different but complementary enzymatic behaviors: Ubc4 supports the rapid monoubiquitination of multiple lysines on APC targets, while Ubc1 catalyzes K48-linked polyubiquitin chain assembly on preattached ubiquitins.	Lysine	138-145	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	168-172
16188974-2	2005	Although many paramyxovirus F proteins are proteolytically processed by the cellular protease furin at a multibasic cleavage motif, cleavage of the newly emerged Hendra virus F protein occurs by a previously unidentified cellular protease following a single lysine at residue 109.	Lysine	258-264	furin	Chlorocebus sabaeus	94-99
16166628-0	2005	Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.	Lysine	76-82	sirtuin 1	Homo sapiens	49-54
26837761-8	2016	Accordingly, compound-mediated KDM1A eviction was associated with elevated levels of local histone H3 lysine 4 dimethylation, and increased target gene expression, which was further accompanied by cellular differentiation and induction of cell death.	Lysine	102-108	lysine demethylase 1A	Homo sapiens	31-36
26743126-11	2016	Furthermore, we have identified a lysine degradation pathway as a common regulatory pathway for miR-1260a, miR-1260b, and miR-3182 by using DIANA-mirPath.	Lysine	34-40	microRNA 3182	Homo sapiens	122-130
17569509-4	2007	Lysine-specific demethylase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), thus repressing transcription.	Lysine	69-75	REST corepressor 1	Homo sapiens	123-129
26979866-9	2016	RESULTS: We found that (1) SUMO1 knockdown worsened ischemic damage and reduced the protective effect of preconditioning; (2) SUMO1 bound to NCX3 at lysine residue 590, and its silencing increased NCX3 degradation; and (3) NCX3 sumoylation participates in SUMO1 protective role during ischemic preconditioning.	Lysine	149-155	small ubiquitin-like modifier 1	Rattus norvegicus	126-131
26979866-9	2016	RESULTS: We found that (1) SUMO1 knockdown worsened ischemic damage and reduced the protective effect of preconditioning; (2) SUMO1 bound to NCX3 at lysine residue 590, and its silencing increased NCX3 degradation; and (3) NCX3 sumoylation participates in SUMO1 protective role during ischemic preconditioning.	Lysine	149-155	small ubiquitin-like modifier 1	Rattus norvegicus	126-131
16171390-0	2005	Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells.	Lysine	13-19	integrin subunit alpha M	Homo sapiens	97-102
17604720-5	2007	HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus.	Lysine	109-115	HOX transcript antisense RNA	Homo sapiens	0-6
15998636-6	2005	We constructed a set of Npl3 proteins in which subsets of the RGG arginines were mutated to lysine.	Lysine	92-98	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	24-28
15998636-9	2005	Npl3 with all 15 RGG arginines mutated to lysine exited the nucleus independent of Hmt1, indicating a direct effect of methylation on Npl3 transport.	Lysine	42-48	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	0-4
27029215-5	2016	The degradation of CREB-H-DeltaTC was mediated by lysine 48-linked polyubiquitination and could be inhibited by proteasome inhibitor.	Lysine	50-56	cAMP responsive element binding protein 3 like 3	Homo sapiens	19-25
27030801-14	2016	Notably, association with HMO1 creates a less dynamic chromatin environment that depends on its lysine-rich domain.	Lysine	96-102	Hmo1p	Saccharomyces cerevisiae S288C	26-30
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	115-118	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	39-44
16023247-1	2005	BACKGROUND/AIMS: Lysyl-oxidases catalyze the oxidation of lysine residues in collagen and elastin thereby promoting their polymerization.	Lysine	58-64	elastin	Homo sapiens	90-97
16023247-8	2005	We have found that Loxl2 is able to oxidize lysine residues of collagen, and behaves in that respect similarly to Lox.	Lysine	44-50	lysyl oxidase	Homo sapiens	19-22
27462448-7	2016	USP9x acts to deubiquitylate Angiomotin at lysine 496, resulting in stabilization of Angiomotin and lower YAP/TAZ activity.	Lysine	43-49	ubiquitin specific peptidase 9 X-linked	Homo sapiens	0-5
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	140-143	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	39-44
17426036-6	2007	Using the dimeric E2, UbcH13/Uev1a, they attach Lys(63) chains, but with UbcH1 (E2-25K), MuRF1 synthesizes Lys(48) chains on the substrate.	Lysine	48-51	ubiquitin conjugating enzyme E2 N	Homo sapiens	22-28
17426036-6	2007	Using the dimeric E2, UbcH13/Uev1a, they attach Lys(63) chains, but with UbcH1 (E2-25K), MuRF1 synthesizes Lys(48) chains on the substrate.	Lysine	48-51	ubiquitin conjugating enzyme E2 V1	Homo sapiens	29-34
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Lysine	95-98	coagulation factor X	Homo sapiens	58-61
16042383-7	2005	Analysis of the X-ray crystal structure of fXa indicated that Glu-84 may interact by a salt bridge with Lys-109, explaining the lack of expression of E84A and the lower activity of K109A in the absence of fVa.	Lysine	104-107	coagulation factor X	Homo sapiens	43-46
26890998-4	2016	After one round of MAPS analoging, we found novel substitutions at multiple residue positions not previously identified, specifically glutamic acid at positions 10 or 11 or lysine at position 18, that produce peptides with single digit nanomolar potency on NaV1.7 and 500-fold selectivity against off-target sodium channels.	Lysine	173-179	sodium voltage-gated channel alpha subunit 9	Homo sapiens	257-263
17426036-6	2007	Using the dimeric E2, UbcH13/Uev1a, they attach Lys(63) chains, but with UbcH1 (E2-25K), MuRF1 synthesizes Lys(48) chains on the substrate.	Lysine	107-110	ubiquitin conjugating enzyme E2 N	Homo sapiens	22-28
17439941-3	2007	To be active, cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein Nedd8.	Lysine	84-90	CDK2 associated cullin domain 1	Homo sapiens	106-112
15986205-3	2005	Trimethylation of histone H3 on lysine 27, mediated by a PcG protein complex consisting of Eed, Ezh2, and Suz12, is integral in differentiation, stem cell self-renewal, and tumorigenesis.	Lysine	32-38	embryonic ectoderm development	Homo sapiens	91-94
17434460-6	2007	A lysine to proline mutation was introduced into the TM2-TM3 linker region at position 281 (K281P) of the alpha1 GlyR.	Lysine	2-8	glycine receptor alpha 1	Homo sapiens	106-117
15969742-6	2005	Analysis of histone modifications at the promoters of the act and pci genes revealed that methylation of histone H3 on lysine 4 correlated with their expression pattern in both cell types.	Lysine	119-125	serpin family A member 3	Homo sapiens	58-61
26813693-2	2016	SETDB1 methylates lysine 9 of histone 3 (H3K9), utilizing S-adenosylmethionine (SAM) as the methyl donor and its catalytic activity, has been reported to be regulated by a partner protein ATF7IP.	Lysine	18-24	activating transcription factor 7 interacting protein	Homo sapiens	188-194
26555343-5	2016	Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(epsilon)-methylated lysine residue in different conformations during catalysis.	Lysine	40-46	lysine demethylase 4A	Homo sapiens	122-127
15951443-8	2005	These data are used to interpret the expression of the stoned locus and in particular, to explain the altered stoned protein levels in the stoned-temperature-sensitive mutant allele, which replaces a lysine with a methionine codon early in the first, stonedA, cistron.	Lysine	200-206	stoned A	Drosophila melanogaster	55-61
15951443-8	2005	These data are used to interpret the expression of the stoned locus and in particular, to explain the altered stoned protein levels in the stoned-temperature-sensitive mutant allele, which replaces a lysine with a methionine codon early in the first, stonedA, cistron.	Lysine	200-206	stoned A	Drosophila melanogaster	110-116
26555343-5	2016	Demethylation of a trans-C-4/C-5 dehydrolysine substrate analogue was observed with representative KDM4 subfamily members KDM4A, KDM4B and KDM4E, and KDM7B, which are predicted, based on crystallographic analyses, to bind the N(epsilon)-methylated lysine residue in different conformations during catalysis.	Lysine	40-46	lysine demethylase 4E	Homo sapiens	139-144
17568193-4	2007	Here we discuss the recent characterization of a new class of demethylase enzyme, the JARID1 family, which catalyzes the removal of methyl groups from lysine 4 of histone H3.	Lysine	151-157	little imaginal discs	Drosophila melanogaster	86-92
15951443-8	2005	These data are used to interpret the expression of the stoned locus and in particular, to explain the altered stoned protein levels in the stoned-temperature-sensitive mutant allele, which replaces a lysine with a methionine codon early in the first, stonedA, cistron.	Lysine	200-206	stoned A	Drosophila melanogaster	110-116
26631721-7	2016	Because p35 is myristoylated at the N-terminal glycine, the possible ubiquitination sites are the lysine residues in p35.	Lysine	98-104	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	8-11
17395554-4	2007	Studies in yeast suggest the modification of PCNA by lysine 63-linked poly-ubiquitin (K63-polyUb) chains as a key mediator of the error-free damage avoidance pathway.	Lysine	53-59	proliferating cell nuclear antigen	Homo sapiens	45-49
26631721-7	2016	Because p35 is myristoylated at the N-terminal glycine, the possible ubiquitination sites are the lysine residues in p35.	Lysine	98-104	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	117-120
16134340-4	2005	The effects of the o2 gene were large on lysine content and protein content while minor on oil content.	Lysine	41-47	regulatory protein opaque-2	Zea mays	19-21
17517655-4	2007	Here, quantum mechanical/molecular mechanical molecular dynamics and free-energy simulations are performed on human PKMT SET7/9 and its mutants to understand two outstanding questions for the reaction catalyzed by PKMTs: the mechanism for deprotonation of positively charged methyl lysine (lysine) and origin of product specificity.	Lysine	290-296	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	121-127
15843371-1	2005	Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine residues.	Lysine	149-155	lysyl oxidase	Homo sapiens	0-13
15843371-1	2005	Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine residues.	Lysine	149-155	lysyl oxidase	Homo sapiens	15-18
15843371-1	2005	Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine residues.	Lysine	149-155	elastin	Homo sapiens	129-136
26794039-1	2016	Lysine-specific demethylase 2 (LSD2) demethylates mono- and dimethylated Lys-4 of histone H3 (H3K4me1 and H3K4me2).	Lysine	0-3	lysine demethylase 1B	Homo sapiens	31-35
17511883-2	2007	MOF acetylates histone H4 at lysine 16 (H4K16ac).	Lysine	29-35	males absent on the first	Drosophila melanogaster	0-3
26856877-3	2016	Members of the BET family of chromatin adaptors contain tandem bromodomains that mediate binding to acetylated lysines on target proteins to regulate gene expression.	Lysine	111-118	delta/notch-like EGF repeat containing	Mus musculus	15-18
15920479-4	2005	Strains lacking Sas2 histone acetylase or the histone methylases that modify lysines 4 (Set1) or 79 (Dot1) of H3 display accelerated Sir3 accumulation at HMR or its spreading away from the telomere, suggesting that these histone modifications exert distinct inhibitory effects on heterochromatin formation.	Lysine	77-84	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	133-137
17360705-0	2007	Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.	Lysine	12-18	synuclein, alpha	Mus musculus	68-83
15964997-4	2005	We show that RNA polymerase II (RNAPolII) preinitiation complex recruitment and H3 Lys 4 (H3-K4) methylation at the Xist promoter form the basis of the Xist expression profiles that drives both imprinted and random XCI.	Lysine	83-86	inactive X specific transcripts	Mus musculus	116-120
15964997-4	2005	We show that RNA polymerase II (RNAPolII) preinitiation complex recruitment and H3 Lys 4 (H3-K4) methylation at the Xist promoter form the basis of the Xist expression profiles that drives both imprinted and random XCI.	Lysine	83-86	inactive X specific transcripts	Mus musculus	152-156
26721445-0	2016	HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases.	Lysine	49-55	histone deacetylase 9	Homo sapiens	0-4
26721445-3	2016	We describe a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify lysine acetylation and methylation and arginine methylation on histones extracted from cultured cells treated with HDAC inhibitors.	Lysine	101-107	histone deacetylase 9	Homo sapiens	216-220
17360705-7	2007	These results suggest that the contribution of Ser(129)-phosphorylated alpha-syn to the Lys(63)-linked Ub-conjugates and aggregation of itself may be involved in the biogenesis of LBs in Parkinson disease and other related synucleinopathies.	Lysine	88-91	synuclein, alpha	Mus musculus	71-80
15939881-1	2005	Chromatin immunoprecipitation with anti-acetyl histone H3 (K9 and K14) and anti-acetyl histone H4 (K5, K8, K12, and K16) antibodies shows that Lys-9 and/or Lys-14 of histone H3, but not the relevant sites of histone H4 in nucleosomes at the repressed MFA2 promoter, are hyperacetylated after UV irradiation.	Lysine	143-146	mating pheromone a	Saccharomyces cerevisiae S288C	251-255
17496917-3	2007	Recent studies have shown that polyubiquitination of signalling proteins through lysine (Lys)-63-linked polyubiquitin chains plays an important role in the activation of TAK1 and IKK.	Lysine	81-87	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	170-174
15790557-3	2005	Disease-associated mutations in Aprataxin target a histidine triad domain that is similar to Hint, a universally conserved AMP-lysine hydrolase, or truncate the protein NH2-terminal to a zinc finger.	Lysine	127-133	aprataxin	Homo sapiens	32-41
15790557-4	2005	With novel fluorigenic substrates, we demonstrate that Aprataxin possesses an active-site-dependent AMP-lysine and GMP-lysine hydrolase activity that depends additionally on the zinc finger for protein stability and on the forkhead associated domain for enzymatic activity.	Lysine	104-110	aprataxin	Homo sapiens	55-64
15790557-4	2005	With novel fluorigenic substrates, we demonstrate that Aprataxin possesses an active-site-dependent AMP-lysine and GMP-lysine hydrolase activity that depends additionally on the zinc finger for protein stability and on the forkhead associated domain for enzymatic activity.	Lysine	119-125	aprataxin	Homo sapiens	55-64
26416711-1	2016	BACKGROUND: Jumonji-domain containing 3 (JMJD3) affects transcriptional regulation by demethylating lysine 27 residue of histone 3.	Lysine	100-106	lysine demethylase 6B	Homo sapiens	12-39
26416711-1	2016	BACKGROUND: Jumonji-domain containing 3 (JMJD3) affects transcriptional regulation by demethylating lysine 27 residue of histone 3.	Lysine	100-106	lysine demethylase 6B	Homo sapiens	41-46
17496917-3	2007	Recent studies have shown that polyubiquitination of signalling proteins through lysine (Lys)-63-linked polyubiquitin chains plays an important role in the activation of TAK1 and IKK.	Lysine	89-92	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	170-174
26596766-1	2016	GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5) is a histone acetyltransferase (HAT) and the catalytic subunit of several multicomponent HAT complexes that acetylate lysine residues of histone H3.	Lysine	159-165	general control non-repressible 5	Arabidopsis thaliana	0-33
17411091-2	2007	We demonstrate that chemically cross-linked elastin-like polypeptide (ELP) hydrogels can be rapidly formed in aqueous solution by reacting lysine-containing ELPs with an organophosphorous cross-linker, beta-[tris(hydroxymethyl)phosphino]propionic acid (THPP) under physiological conditions.	Lysine	139-145	nuclear receptor subfamily 5 group A member 1	Homo sapiens	44-68
26596766-1	2016	GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5) is a histone acetyltransferase (HAT) and the catalytic subunit of several multicomponent HAT complexes that acetylate lysine residues of histone H3.	Lysine	159-165	general control non-repressible 5	Arabidopsis thaliana	35-39
15713849-5	2005	This finding now expands the diversity of GPCR sorting motifs to include internal and C-terminal PDZ ligands, tyrosine-based motifs, and lysine residues capable of being ubiquitinated.	Lysine	137-143	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	42-46
15766567-0	2005	Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.	Lysine	85-91	homeodomain interacting protein kinase 2	Homo sapiens	31-71
17411091-2	2007	We demonstrate that chemically cross-linked elastin-like polypeptide (ELP) hydrogels can be rapidly formed in aqueous solution by reacting lysine-containing ELPs with an organophosphorous cross-linker, beta-[tris(hydroxymethyl)phosphino]propionic acid (THPP) under physiological conditions.	Lysine	139-145	nuclear receptor subfamily 5 group A member 1	Homo sapiens	70-73
15766567-2	2005	Here we show that human HIPK2 is modified by sumoylation at lysine 25, as revealed by in vivo and in vitro experiments.	Lysine	60-66	homeodomain interacting protein kinase 2	Homo sapiens	24-29
26538142-8	2016	We also show that, unlike vertebrates, insect SUMO3 proteins cannot form polySUMO chains due to the loss of critical lysine residues within the N-terminal part of the protein.	Lysine	117-123	small ubiquitin like modifier 3	Homo sapiens	46-51
17411091-3	2007	The mechanical properties of the cross-linked ELP hydrogels were largely modulated by the molar concentration of lysine residues in the ELP and the pH at which the cross-linking reaction was carried out.	Lysine	113-119	nuclear receptor subfamily 5 group A member 1	Homo sapiens	46-49
17411091-3	2007	The mechanical properties of the cross-linked ELP hydrogels were largely modulated by the molar concentration of lysine residues in the ELP and the pH at which the cross-linking reaction was carried out.	Lysine	113-119	nuclear receptor subfamily 5 group A member 1	Homo sapiens	136-139
17442954-10	2007	In conclusion, the MASP binding site of MBL involves a sequence stretch centered on residue Lys(55), which may form an ionic bond representing the major component of the MBL-MASP interaction.	Lysine	92-95	MBL associated serine protease 1	Homo sapiens	19-23
26601948-7	2016	This increased affinity for longer chains was dependent on the Vps27/Hrs/STAM domain of STAM and required that the substrate ubiquitin chain contain homogenous Lys(63)-linkages.	Lysine	160-163	signal transducing adaptor molecule	Homo sapiens	73-77
26601948-7	2016	This increased affinity for longer chains was dependent on the Vps27/Hrs/STAM domain of STAM and required that the substrate ubiquitin chain contain homogenous Lys(63)-linkages.	Lysine	160-163	signal transducing adaptor molecule	Homo sapiens	88-92
26601948-9	2016	Finally, we generated a structural model of AMSH-STAM to show how the complex binds Lys(63)-linked ubiquitin chains and cleaves at the distal end.	Lysine	84-87	signal transducing adaptor molecule	Homo sapiens	49-53
15817126-0	2005	Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor.	Lysine	15-21	taste 1 receptor member 3	Rattus norvegicus	63-70
15817126-6	2005	Additional substitution of lysine 735 by phenylalanine in rTas1r3 results in a rat sweet taste receptor that is as sensitive to lactisole as its human counterpart.	Lysine	27-33	taste 1 receptor member 3	Rattus norvegicus	58-65
26774283-2	2016	We show here that a dimer of the shelterin subunit TRF2 wraps ~ 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.	Lysine	93-99	telomeric repeat binding factor 2	Homo sapiens	51-55
17442954-10	2007	In conclusion, the MASP binding site of MBL involves a sequence stretch centered on residue Lys(55), which may form an ionic bond representing the major component of the MBL-MASP interaction.	Lysine	92-95	mannose binding lectin 2	Homo sapiens	40-43
26240060-1	2016	Lysine-specific demethylase-1 (LSD1) removes the methyl groups from mono- and di-methylated lysine 4 of histone H3.	Lysine	92-98	lysine demethylase 1A	Homo sapiens	0-29
15798205-6	2005	The mutant that substitutes the triple lysine residues (Lys101, Lys102, and Lys103) within the PLD2-PX domain with alanine abolishes interaction with the PKCzeta-kinase domain and activation of PKCzeta.	Lysine	39-45	phospholipase D2	Homo sapiens	95-99
15798205-6	2005	The mutant that substitutes the triple lysine residues (Lys101, Lys102, and Lys103) within the PLD2-PX domain with alanine abolishes interaction with the PKCzeta-kinase domain and activation of PKCzeta.	Lysine	39-45	protein kinase C zeta	Homo sapiens	154-161
15798205-6	2005	The mutant that substitutes the triple lysine residues (Lys101, Lys102, and Lys103) within the PLD2-PX domain with alanine abolishes interaction with the PKCzeta-kinase domain and activation of PKCzeta.	Lysine	39-45	protein kinase C zeta	Homo sapiens	194-201
15798214-2	2005	In particular, the histone H3 lysine 36 (K36) methyltransferase Set2 has recently been shown to associate with the phosphorylated C-terminal domain (CTD) of RNA polymerase II (RNAPII), implying that this enzyme has an important role in the transcription elongation process.	Lysine	30-36	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	64-68
17442954-10	2007	In conclusion, the MASP binding site of MBL involves a sequence stretch centered on residue Lys(55), which may form an ionic bond representing the major component of the MBL-MASP interaction.	Lysine	92-95	mannose binding lectin 2	Homo sapiens	170-173
17442954-10	2007	In conclusion, the MASP binding site of MBL involves a sequence stretch centered on residue Lys(55), which may form an ionic bond representing the major component of the MBL-MASP interaction.	Lysine	92-95	MBL associated serine protease 1	Homo sapiens	174-178
17314394-8	2007	Chromatin immunoprecipitation analyses of lysines K4, K9, and K27 of histone H3 on OCT4 and NANOG indicate that primary chromatin remodeling determinants are acetylation of H3K9 and demethylation of dimethylated H3K9.	Lysine	42-49	POU class 5 homeobox 1	Homo sapiens	83-87
15590654-4	2005	PKCiota PB1 presents an OPR, PC, and AID (OPCA) motif, 28 amino acid residues with acidic and hydrophobic residues, which interacts with the conserved lysine residue of Par6alpha PB1 in a front and back manner.	Lysine	151-157	submaxillary gland androgen regulated protein 3A	Homo sapiens	8-11
15590654-4	2005	PKCiota PB1 presents an OPR, PC, and AID (OPCA) motif, 28 amino acid residues with acidic and hydrophobic residues, which interacts with the conserved lysine residue of Par6alpha PB1 in a front and back manner.	Lysine	151-157	par-6 family cell polarity regulator alpha	Homo sapiens	169-178
15590654-4	2005	PKCiota PB1 presents an OPR, PC, and AID (OPCA) motif, 28 amino acid residues with acidic and hydrophobic residues, which interacts with the conserved lysine residue of Par6alpha PB1 in a front and back manner.	Lysine	151-157	submaxillary gland androgen regulated protein 3A	Homo sapiens	179-182
15590654-5	2005	On the interface, several salt bridges are formed including the conserved acidic residues on the OPCA motif of PKCiota PB1 and the conserved lysine residue on the Par6alpha PB1.	Lysine	141-147	par-6 family cell polarity regulator alpha	Homo sapiens	163-172
15590654-5	2005	On the interface, several salt bridges are formed including the conserved acidic residues on the OPCA motif of PKCiota PB1 and the conserved lysine residue on the Par6alpha PB1.	Lysine	141-147	submaxillary gland androgen regulated protein 3A	Homo sapiens	173-176
26240060-1	2016	Lysine-specific demethylase-1 (LSD1) removes the methyl groups from mono- and di-methylated lysine 4 of histone H3.	Lysine	92-98	lysine demethylase 1A	Homo sapiens	31-35
26652247-2	2016	Lysine specific demethylase 1 (LSD1) is responsible for maintaining balanced methylation levels at histone H3 lysine 4 (H3K4).	Lysine	110-116	lysine demethylase 1A	Homo sapiens	0-29
26652247-2	2016	Lysine specific demethylase 1 (LSD1) is responsible for maintaining balanced methylation levels at histone H3 lysine 4 (H3K4).	Lysine	110-116	lysine demethylase 1A	Homo sapiens	31-35
17259170-4	2007	Here, we demonstrate that UCH-L1 is post-translationally modified by monoubiquitin in cells, at lysine residues near the active site.	Lysine	96-102	ubiquitin C-terminal hydrolase L1	Homo sapiens	26-32
26719415-3	2016	Here, we demonstrate for the first time to our knowledge that MyD88 protein undergoes lysine 63 (K63)-linked polyubiquitination, which is functionally critical for mediating TLR-MyD88-dependent signaling.	Lysine	86-92	myeloid differentiation primary response gene 88	Mus musculus	62-67
26719415-3	2016	Here, we demonstrate for the first time to our knowledge that MyD88 protein undergoes lysine 63 (K63)-linked polyubiquitination, which is functionally critical for mediating TLR-MyD88-dependent signaling.	Lysine	86-92	myeloid differentiation primary response gene 88	Mus musculus	178-183
26719415-4	2016	Deubiquitinase CYLD negatively regulates MyD88-mediated signaling by directly interacting with MyD88 and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 at lysine 231.	Lysine	214-220	myeloid differentiation primary response gene 88	Mus musculus	41-46
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Lysine	90-93	prepronociceptin	Mus musculus	98-103
15721581-0	2005	Specificity in the coacervation of tropoelastin: solvent exposed lysines.	Lysine	65-72	elastin	Homo sapiens	35-47
17205979-7	2007	Constitutive negative mutants, mimicking hypomethylated RARalpha, were prepared by replacing methylated Lys(347) with either alanine or glutamine.	Lysine	104-107	retinoic acid receptor alpha	Homo sapiens	56-64
15721581-7	2005	A specificity for particular lysines allowed for the construction of a model for the first close contacts between domains and the first detailed study of the cross-linking of tropoelastin.	Lysine	29-36	elastin	Homo sapiens	175-187
15721582-1	2005	Tropoelastin is encoded by a single human gene that spans 36 exons and is oxidized in vivo by mammalian lysyl oxidase at the epsilon amino group of available lysines to give the adipic semialdehyde, which then facilitates covalent cross-link formation in an enzyme-free process involving tropoelastin association.	Lysine	158-165	elastin	Homo sapiens	0-12
26977352-3	2016	We successfully tested Frapid on 3 bromodomains as well as on spindlin1 (SPIN1), a methyl lysine binder, for the first time.	Lysine	90-96	spindlin 1	Homo sapiens	73-78
17205979-8	2007	A constitutive positive mutant partially mimicking the hypermethylated RARalpha was generated by replacing the methylated lysine residue with phenylalanine, a bulky hydrophobic amino acid, to introduce a site-specific hydrophobicity similar to that contributed by lysine methylation.	Lysine	122-128	retinoic acid receptor alpha	Homo sapiens	71-79
17205979-8	2007	A constitutive positive mutant partially mimicking the hypermethylated RARalpha was generated by replacing the methylated lysine residue with phenylalanine, a bulky hydrophobic amino acid, to introduce a site-specific hydrophobicity similar to that contributed by lysine methylation.	Lysine	264-270	retinoic acid receptor alpha	Homo sapiens	71-79
26837744-1	2016	SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine residues of proteins.	Lysine	189-195	small ubiquitin like modifier 2	Homo sapiens	168-173
26837744-1	2016	SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine residues of proteins.	Lysine	189-195	small ubiquitin like modifier 3	Homo sapiens	179-184
15691768-5	2005	Strikingly, dBre1 mutant clones show much reduced levels of methylated lysine 4 on histone 3 (H3K4m), a chromatin mark that has been implicated in transcriptional activation.	Lysine	71-77	Bre1	Drosophila melanogaster	12-17
17205979-9	2007	Studies of these mutants revealed that trimethylation of Lys(347) of RARalpha facilitated its interactions with cofactors p300/CREB-binding protein-associated factor and receptor-interacting protein 140 as well as its heterodimeric partner retinoid X receptor, suggesting that site-specific hydrophobicity at Lys(347) enhanced molecular interaction of RARalpha with its modulators.	Lysine	57-60	retinoic acid receptor alpha	Homo sapiens	69-77
17084093-4	2007	The biotinylation of recombinant Itch in transiently transfected CHO Tet-On cells required biotin supplementation and coexpression of BirA, occurred quantitatively and specifically on the lysine residue of the BioTag, and enabled detection of Itch by Western blot in as little as 10ng of total lysate protein.	Lysine	188-194	E3 ubiquitin-protein ligase Itchy homolog	Cricetulus griseus	33-37
15565646-4	2005	The results indicate that the three lysines present in the basic region of residues 228-231 of CK1alpha are necessary for the binding of CK1 to axin.	Lysine	36-43	axin 1	Mus musculus	144-148
27247942-0	2016	Histone Lysine Methylation in TGF-beta1 Mediated p21 Gene Expression in Rat Mesangial Cells.	Lysine	8-14	KRAS proto-oncogene, GTPase	Rattus norvegicus	49-52
17389028-2	2007	This allele shows a sequence identical to that of HLA-B*5801, except for a nucleotide substitution that changes GAG to AAG at codon 128, resulting in an amino acid change from glutamic acid to lysine in the protein.	Lysine	193-199	major histocompatibility complex, class I, B	Homo sapiens	50-55
26900409-4	2016	METHODS: The GNPs-Pep-A conjugate was prepared by functionalization of GNPs with peptide-A (Pro-His-Cys-Lys-Arg-Met; Pep-A) using thioctic acid as a linker molecule.	Lysine	104-107	carnosine dipeptidase 2	Homo sapiens	18-23
15531760-8	2005	Finally the purified recombinant SCF(MAFbx) complex (SCF, Skp1, Cdc53/Cullin 1, F-box protein) mediated MyoD ubiquitination in vitro in a lysine-dependent pathway.	Lysine	138-144	F-box protein 32	Homo sapiens	37-42
15531760-9	2005	Mutation of the lysine 133 in MyoD prevented its ubiquitination by the recombinant SCF(MAFbx) complex.	Lysine	16-22	F-box protein 32	Homo sapiens	87-92
15371351-1	2005	We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine (K)79 residue of histone H3.	Lysine	172-178	grappa	Drosophila melanogaster	38-44
17323935-7	2007	These results suggest that both Arg-200 and Lys-201 of TF interact with EGF-1 of fX to facilitate the optimal docking of the substrate into the catalytic groove of the protease in the activation complex.	Lysine	44-47	coagulation factor III, tissue factor	Homo sapiens	55-57
15371351-1	2005	We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine (K)79 residue of histone H3.	Lysine	172-178	grappa	Drosophila melanogaster	46-49
15629079-2	2005	METHODS: Full-length HIV-1 Tat gene was amplified artificially by PCR and Tat gene was mutated site-specifically (substitution the codons AAG encoding the lysine at the 28th and the 50th site by the CAG encoding glutamine) in order to eliminate the transcriptional activity of Tat protein.	Lysine	155-161	Tat	Human immunodeficiency virus 1	27-30
26139117-5	2016	Melittin analogues that have a proline residue substituted for an alanine, lysine or cysteine have been studied with both model membrane systems and living cells.	Lysine	75-81	melittin	Apis mellifera	0-8
26864977-1	2016	Hb Agenogi [beta90(F6)Glu Lys (GAG&gt;AAG) HBB: c.271G&gt;A)] is a very rare beta-globin chain variant.	Lysine	26-29	N-methylpurine DNA glycosylase	Homo sapiens	38-41
15629079-2	2005	METHODS: Full-length HIV-1 Tat gene was amplified artificially by PCR and Tat gene was mutated site-specifically (substitution the codons AAG encoding the lysine at the 28th and the 50th site by the CAG encoding glutamine) in order to eliminate the transcriptional activity of Tat protein.	Lysine	155-161	Tat	Human immunodeficiency virus 1	74-77
17323935-7	2007	These results suggest that both Arg-200 and Lys-201 of TF interact with EGF-1 of fX to facilitate the optimal docking of the substrate into the catalytic groove of the protease in the activation complex.	Lysine	44-47	G elongation factor mitochondrial 1	Homo sapiens	72-77
15629079-2	2005	METHODS: Full-length HIV-1 Tat gene was amplified artificially by PCR and Tat gene was mutated site-specifically (substitution the codons AAG encoding the lysine at the 28th and the 50th site by the CAG encoding glutamine) in order to eliminate the transcriptional activity of Tat protein.	Lysine	155-161	Tat	Human immunodeficiency virus 1	74-77
17245368-8	2007	KEY RESULTS: Using our novel assay, we demonstrate that the basic L-alpha-amino acids ornithine, lysine, and arginine are the most potent agonists at wild-type mouse GPRC6A.	Lysine	97-103	G protein-coupled receptor, family C, group 6, member A	Mus musculus	166-172
15465824-4	2004	Other simpler extensins are recalcitrant to isolation including the ubiquitous P3-type extensin whose major repetitive motif, Hyp)(4)-Ser-Hyp-Ser-(Hyp)(4)-Tyr-Tyr-Tyr-Lys, is of particular interest, not least because its Tyr-Tyr-Tyr intramolecular isodityrosine cross-link motifs are also putative candidates for further intermolecular cross-linking to form di-isodityrosine.	Lysine	167-170	extensin	Nicotiana tabacum	14-22
15465824-5	2004	Therefore, we designed a set of extensin analogs encoding tandem repeats of the P3 motif, including Tyr --&gt; Phe and Lys --&gt; Leu variations.	Lysine	119-122	extensin	Nicotiana tabacum	32-40
27652271-0	2016	Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.	Lysine	23-29	KRAS proto-oncogene, GTPase	Rattus norvegicus	45-48
27652271-4	2016	However, precise regulatory mechanism of histone lysine methylation (HKme) mediating p21 related hypertrophy associated with DN is not clear.	Lysine	49-55	KRAS proto-oncogene, GTPase	Rattus norvegicus	85-88
17098746-5	2007	In addition to the C-terminal lysine residues, FBXO11 can also promote Nedd8 conjugation to Lys-320 and Lys-321, and neddylation of p53 leads to suppression of p53 function.	Lysine	92-95	F-box protein 11	Homo sapiens	47-53
26497635-2	2015	It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both di-methylation and tri-methylation of Histone H3 at lysine 27 (H3K27me2/3).	Lysine	150-156	embryonic ectoderm development	Homo sapiens	44-47
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
17098746-5	2007	In addition to the C-terminal lysine residues, FBXO11 can also promote Nedd8 conjugation to Lys-320 and Lys-321, and neddylation of p53 leads to suppression of p53 function.	Lysine	104-107	F-box protein 11	Homo sapiens	47-53
26459223-3	2015	Recent studies have revealed that histone H3 lysine 9 trimethylation (H3K9me3) enrichments on Xm-Xist promoter regions are involved in silencing at the preimplantation stages.	Lysine	45-51	inactive X specific transcripts	Mus musculus	94-101
15506920-3	2004	We have determined the X-ray crystal structure of a Sir2 homologue from yeast Hst2 (yHst2), in various liganded forms, including the yHst2/acetyl-Lys-16 histone H4/NAD(+) ternary complex; we have also performed related biochemical studies to address the conserved mode of catalysis by these enzymes as well as the distinguishing features that allow different members of the family to target their respective cognate substrates.	Lysine	146-149	sirtuin 1	Homo sapiens	52-56
17164290-5	2007	FasL is also directly mono-ubiquitylated at lysines flanking the PRD and mutation of these lysines reduces MVB localisation of FasL.	Lysine	44-51	Fas ligand	Homo sapiens	0-4
15377664-0	2004	Physical association of eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly enhances its binding to eIF3.	Lysine	95-101	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	157-161
15280381-0	2004	Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin.	Lysine	18-24	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	51-56
17164290-5	2007	FasL is also directly mono-ubiquitylated at lysines flanking the PRD and mutation of these lysines reduces MVB localisation of FasL.	Lysine	44-51	Fas ligand	Homo sapiens	127-131
17164290-5	2007	FasL is also directly mono-ubiquitylated at lysines flanking the PRD and mutation of these lysines reduces MVB localisation of FasL.	Lysine	91-98	Fas ligand	Homo sapiens	0-4
26468280-11	2015	However, the lysine acetylation specificity of GCN5 on histone tails or full-length histones was not changed when incorporated in the HAT modules of ATAC or SAGA complexes.	Lysine	13-19	lysine acetyltransferase 2A	Homo sapiens	47-51
17164290-5	2007	FasL is also directly mono-ubiquitylated at lysines flanking the PRD and mutation of these lysines reduces MVB localisation of FasL.	Lysine	91-98	Fas ligand	Homo sapiens	127-131
17077080-5	2006	These lysines are in the negative regulatory domain of c-Myb and also serve as acceptor sites for SUMO-1.	Lysine	6-13	MYB proto-oncogene, transcription factor	Homo sapiens	55-60
26604986-6	2015	In addition, we find that the strongest CBP sites in the genome are found at Polycomb response elements embedded in histone H3 lysine 27 trimethylated (H3K27me3) chromatin, where they correlate with binding of the Pho repressive complex.	Lysine	127-133	nejire	Drosophila melanogaster	40-43
15461503-7	2004	The long PEO spacer is able to compensate the disadvantage of lysine residues locating far from the FAD center in GOx hybrids whose mediation reactions are based on the so-called wipe mechanism.	Lysine	62-68	hydroxyacid oxidase 1	Homo sapiens	114-117
17190600-1	2006	Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established.	Lysine	8-14	tumor protein p53 binding protein 1	Homo sapiens	93-98
15280358-9	2004	ZNF76 is sumoylated by PIAS1 at lysine 411, which is in the minimal TBP-interacting region.	Lysine	32-38	TATA-box binding protein	Homo sapiens	68-71
26807165-2	2015	To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs).	Lysine	33-39	keratin 36	Homo sapiens	65-68
17154537-3	2006	We have attempted to determine the magnitude of cation-pi interactions of Lys with aromatic amino acids in four different proteins (LIVBP, MBP, RBP, and Trx).	Lysine	74-77	SURP and G-patch domain containing 1	Homo sapiens	144-147
26435505-2	2015	LSD1 interacted with androgen receptor (AR) and promoted androgen-dependent transcription of target genes, such as PSA, by ligand-induced demethylation of mono- and dimethylated histone H3 at Lys 9 (H3K9).	Lysine	192-195	lysine demethylase 1A	Homo sapiens	0-4
15469825-2	2004	SirT1 deacetylates histone polypeptides with a preference for histone H4 lysine 16 (H4-K16Ac) and H3 lysine 9 (H3-K9Ac) in vitro.	Lysine	73-79	sirtuin 1	Homo sapiens	0-5
15469825-4	2004	SirT1 interacts with and deacetylates histone H1 at lysine 26.	Lysine	52-58	sirtuin 1	Homo sapiens	0-5
15469825-4	2004	SirT1 interacts with and deacetylates histone H1 at lysine 26.	Lysine	52-58	H1.0 linker histone	Homo sapiens	38-48
15121739-5	2004	FGF-1-induced PN expression was blocked by the FGF-1 receptor antagonist PD-166866 and by inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY-294002, wortmannin), p70S6K (rapamycin), MEK1/2 (U-0126, PD-98059), and p38MAPK (SB-203580) but not of JNK (SP-600125).	Lysine	142-144	fibroblast growth factor 1	Rattus norvegicus	0-5
17154537-3	2006	We have attempted to determine the magnitude of cation-pi interactions of Lys with aromatic amino acids in four different proteins (LIVBP, MBP, RBP, and Trx).	Lysine	74-77	thioredoxin	Homo sapiens	153-156
15121739-5	2004	FGF-1-induced PN expression was blocked by the FGF-1 receptor antagonist PD-166866 and by inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY-294002, wortmannin), p70S6K (rapamycin), MEK1/2 (U-0126, PD-98059), and p38MAPK (SB-203580) but not of JNK (SP-600125).	Lysine	142-144	periostin	Rattus norvegicus	14-16
26454172-9	2015	The optimum activity of AAA at pH &gt; 10 suggests that the reaction mechanism employs Lys(84) as the catalytic base to polarize the Ser(187) nucleophile in the catalytic triad.	Lysine	87-90	AAA1	Homo sapiens	24-27
17116638-3	2006	Direct sequencing revealed a normal alpha-subunit, but detected a nucleotide T-to-A transversion in exon 14 (c.1210T&gt;A) of beta-subunit (Hadhb) which resulted in a missense mutation of methionine to lysine (M404K).	Lysine	202-208	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Mus musculus	140-145
26549758-4	2015	Loss of Ikaros in CD4(-)CD8(-) cells leads to reduced histone H3 lysine 27 trimethylation and ectopic gene expression.	Lysine	65-71	CD8a molecule	Homo sapiens	24-27
15258251-0	2004	Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.	Lysine	17-23	G protein subunit alpha 13	Homo sapiens	50-58
15258251-0	2004	Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.	Lysine	17-23	Rho guanine nucleotide exchange factor 1	Homo sapiens	77-87
15258251-7	2004	We found that lysine 204 of Galpha13 is important for interaction with the RGS domain of p115 or LARG and for the GTPase-activating protein activity of these proteins.	Lysine	14-20	G protein subunit alpha 13	Homo sapiens	28-36
15258251-7	2004	We found that lysine 204 of Galpha13 is important for interaction with the RGS domain of p115 or LARG and for the GTPase-activating protein activity of these proteins.	Lysine	14-20	Rho GTPase activating protein 4	Homo sapiens	89-93
17164360-3	2006	We now report that subjects with the XPD Gln/Gln genotype were inversely associated with adenoma risk [odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.5-1.0] when compared with subjects with the Lys/Lys and Lys/Gln genotypes combined.	Lysine	205-208	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	37-40
15258251-9	2004	We conclude that lysine 204 of Galpha13 is important for interaction with RGS-RhoGEFs and is critically involved in the regulation of their activity.	Lysine	17-23	G protein subunit alpha 13	Homo sapiens	31-39
15162158-7	2004	Systemic administration of the 5-HT3 antagonist LY-278,584 (0-10 mg/kg) decreased intake of both sweetened (2% sucrose+10% ethanol) and unsweetened (10% ethanol) ethanol in wild-type mice only.	Lysine	48-50	hypothermia due to alcohol sensitivity 3	Mus musculus	33-36
26420484-6	2015	HDAC3 recruits components of the PRC2 complex, methyltransferase EZH2, EED, and SUZ12, to the NCOR complex to enrich trimethylation of Lys-27 on histone H3 at the Tgf-beta1 regulatory region and thereby maintains epigenetic silencing of Tgf-beta1 specifically within the second heart field-derived mesenchyme.	Lysine	135-138	embryonic ectoderm development	Homo sapiens	71-74
17164360-3	2006	We now report that subjects with the XPD Gln/Gln genotype were inversely associated with adenoma risk [odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.5-1.0] when compared with subjects with the Lys/Lys and Lys/Gln genotypes combined.	Lysine	209-212	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	37-40
15459393-3	2004	Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys(48)-linked chains.	Lysine	127-130	ubiquitin B S homeolog	Xenopus laevis	34-43
15459393-3	2004	Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys(48)-linked chains.	Lysine	127-130	ubiquitin B S homeolog	Xenopus laevis	94-103
17164360-3	2006	We now report that subjects with the XPD Gln/Gln genotype were inversely associated with adenoma risk [odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.5-1.0] when compared with subjects with the Lys/Lys and Lys/Gln genotypes combined.	Lysine	209-212	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	37-40
17030603-7	2006	In dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected.	Lysine	172-179	Gcn5 acetyltransferase	Drosophila melanogaster	151-155
15280353-3	2004	Analysis of acetylation of specific histone residues revealed that H3(Lys-9), H4(Lys-8), and H4(Lys-12) were preferentially modified in TH1 cells, suggesting a possible contribution of acetylation of these residues for induction of these genes.	Lysine	70-73	negative elongation factor complex member C/D	Homo sapiens	136-139
15280353-3	2004	Analysis of acetylation of specific histone residues revealed that H3(Lys-9), H4(Lys-8), and H4(Lys-12) were preferentially modified in TH1 cells, suggesting a possible contribution of acetylation of these residues for induction of these genes.	Lysine	81-84	negative elongation factor complex member C/D	Homo sapiens	136-139
15280353-3	2004	Analysis of acetylation of specific histone residues revealed that H3(Lys-9), H4(Lys-8), and H4(Lys-12) were preferentially modified in TH1 cells, suggesting a possible contribution of acetylation of these residues for induction of these genes.	Lysine	81-84	negative elongation factor complex member C/D	Homo sapiens	136-139
26544960-0	2015	Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.	Lysine	0-6	valosin containing protein	Mus musculus	26-52
26544960-0	2015	Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.	Lysine	0-6	valosin containing protein	Mus musculus	54-57
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	valosin containing protein	Mus musculus	0-26
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	valosin containing protein	Mus musculus	28-31
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	valosin containing protein	Mus musculus	133-136
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	valosin containing protein lysine (K) methyltransferase	Mus musculus	175-203
26544960-1	2015	Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT).	Lysine	157-163	valosin containing protein lysine (K) methyltransferase	Mus musculus	205-211
15150267-8	2004	Using a rational strategy to identify complex epitopes on proteins showing a highly convoluted architecture, this study definitively identifies the amino acids Lys(713)-Asp(717) as being the key residues recognized by IDR/B-specific anti-TPO aAbs in AITD.	Lysine	160-163	thyroid peroxidase	Homo sapiens	238-241
26544960-4	2015	We show by (I) mass spectrometric analysis, (II) VCPKMT-mediated in vitro methylation of VCP in cell extracts and (III) immunostaining with a methylation specific antibody, that in Vcpkmt-/- mice the methylation of lysine 315 in VCP is completely abolished.	Lysine	215-221	valosin containing protein lysine (K) methyltransferase	Mus musculus	49-55
17030603-8	2006	The data presented here, together with our earlier data on the function of dAda2b, provide evidence that related Ada2 proteins of Drosophila, together with Gcn5 HAT, are involved in the acetylation of specific lysine residues in the N-terminal tails of nucleosomal H3 and H4.	Lysine	210-216	Gcn5 acetyltransferase	Drosophila melanogaster	156-160
26544960-4	2015	We show by (I) mass spectrometric analysis, (II) VCPKMT-mediated in vitro methylation of VCP in cell extracts and (III) immunostaining with a methylation specific antibody, that in Vcpkmt-/- mice the methylation of lysine 315 in VCP is completely abolished.	Lysine	215-221	valosin containing protein lysine (K) methyltransferase	Mus musculus	181-187
17108971-3	2006	Here we report a lysine methyltransferase, Smyd2, that methylates a previously unidentified site, Lys 370, in p53.	Lysine	98-101	SET and MYND domain containing 2	Homo sapiens	43-48
26297866-10	2015	In this regard, certain lysine residues of NFAT5, when kept deacetylated, were found to contribute to its DNA binding and SIRT1 was shown to directly bind K282 of NFAT5.	Lysine	24-30	sirtuin 1	Homo sapiens	122-127
15220341-4	2004	Furthermore, the HRG-plasminogen interaction is lysine-dissociable and involves predominately the amino-terminal domain of HRG, and the fifth kringle domain of plasminogen, but not the carboxyl-terminal lysine of HRG.	Lysine	48-54	histidine rich glycoprotein	Homo sapiens	17-20
17108971-7	2006	We find that Set9-mediated methylation of Lys 372 inhibits Smyd2-mediated methylation of Lys 370, providing regulatory cross-talk between post-translational modifications.	Lysine	42-45	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	13-17
17108971-7	2006	We find that Set9-mediated methylation of Lys 372 inhibits Smyd2-mediated methylation of Lys 370, providing regulatory cross-talk between post-translational modifications.	Lysine	42-45	SET and MYND domain containing 2	Homo sapiens	59-64
15212764-7	2004	By analysis of point mutants, we found that lysines 15 and 16 had a greater contribution to productive interaction between Arf1, ASAP1 and AGAP1 than between Arf1 and Arf GAP1.	Lysine	44-51	ADP ribosylation factor 1	Homo sapiens	123-127
15212764-7	2004	By analysis of point mutants, we found that lysines 15 and 16 had a greater contribution to productive interaction between Arf1, ASAP1 and AGAP1 than between Arf1 and Arf GAP1.	Lysine	44-51	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	129-134
26225839-1	2015	The histone demethylase KDM1A specifically demethylates lysine residues and its deregulation has been implicated in the initiation and progression of various cancers.	Lysine	56-62	lysine demethylase 1A	Homo sapiens	24-29
17108971-7	2006	We find that Set9-mediated methylation of Lys 372 inhibits Smyd2-mediated methylation of Lys 370, providing regulatory cross-talk between post-translational modifications.	Lysine	89-92	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	13-17
17108971-7	2006	We find that Set9-mediated methylation of Lys 372 inhibits Smyd2-mediated methylation of Lys 370, providing regulatory cross-talk between post-translational modifications.	Lysine	89-92	SET and MYND domain containing 2	Homo sapiens	59-64
15446477-6	2004	When ADG was regressed on supplemental lysine intake, the RBV of lysine in L-lysine sulfate was 99% of the RBV of lysine in L-lysine HCl.	Lysine	39-45	ADG	Sus scrofa	5-8
15446477-6	2004	When ADG was regressed on supplemental lysine intake, the RBV of lysine in L-lysine sulfate was 99% of the RBV of lysine in L-lysine HCl.	Lysine	65-71	ADG	Sus scrofa	5-8
17108971-8	2006	In addition, we show that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and Smyd2.	Lysine	51-54	SET and MYND domain containing 2	Homo sapiens	158-163
15446477-6	2004	When ADG was regressed on supplemental lysine intake, the RBV of lysine in L-lysine sulfate was 99% of the RBV of lysine in L-lysine HCl.	Lysine	65-71	ADG	Sus scrofa	5-8
17108971-8	2006	In addition, we show that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and Smyd2.	Lysine	74-77	SET and MYND domain containing 2	Homo sapiens	158-163
17005568-0	2006	A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.	Lysine	107-113	protein-lysine N-methyltransferase	Saccharomyces cerevisiae S288C	47-51
15240822-8	2004	In an HDA1 deletion, many Tup1-repressed genes are hyperacetylated at lysine 18 of histone H3, yet are not derepressed, indicating deacetylation alone is not sufficient to repress most Tup1-controlled genes.	Lysine	70-76	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	6-10
26492085-1	2015	G9a is a lysine methyltransferase (KMTase) for histone H3 lysine 9 that plays critical roles in a number of biological processes.	Lysine	9-15	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
16715135-7	2006	DNMT1 or DNMT3b knockout reduced dimethylated lysine-9 (diMe-H3K9) levels, but did not significantly affect dimethylated lysine-4 (diMe-H3K4) or acetylated lysine-9 (Ac-H3-K9) levels.	Lysine	46-52	DNA methyltransferase 3 beta	Homo sapiens	9-15
26281976-4	2015	We describe here the expression in the yeast Pichia pastoris of a mutant bovine beta-LG, in which lysine at position 69, in the main epitopes of the protein, was changed into asparagine (Lys69Asn).	Lysine	98-104	beta-lactoglobulin	Bos taurus	80-87
15315757-5	2004	Unlike SPO-11, HIM-17 is also required for proper accumulation of histone H3 methylation at lysine 9 on meiotic prophase chromosomes.	Lysine	92-98	High Incidence of Males (increased X chromosome loss)	Caenorhabditis elegans	15-21
17080225-3	2006	Plasminogen activation was impaired by addition of the lysine analogue 6-aminohexanoic acid, and by addition of t-PA and u-PA neutralizing antibodies, suggesting that it depends on binding to cell surface COOH-terminal lysine residues, and on plasminogen activator activity.	Lysine	219-225	plasminogen activator, urokinase	Mus musculus	121-125
15280549-1	2004	An E2 ubiquitin-conjugating enzyme, Rad6, working with an E3 ubiquitin ligase Bre1, catalyzes monoubiquitylation of histone H2B on a C-terminal lysine residue.	Lysine	144-150	histone H2B	Saccharomyces cerevisiae S288C	116-127
15269344-6	2004	We show that the recruitment of G9a to the human p21(waf1/cdi1) promoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter.	Lysine	202-205	euchromatic histone lysine methyltransferase 2	Homo sapiens	32-35
26256448-5	2015	A chromatin immunoprecipitation assay revealed that miR-139 was epigenetically silenced by histone H3 lysine 27 trimethylation (H3K27me3) of its host gene PDE2A and this process was independent of promoter DNA methylation.	Lysine	102-108	microRNA 139	Homo sapiens	52-59
16956366-5	2006	These three C-terminal fragments inhibited furin with Ki values around 2 x 10(-7) m while the full-length histone H1.2 inhibited it with a lesser activity, suggesting that the inhibitory activity relies on the C-terminal lysine-rich domain.	Lysine	221-227	H1.2 linker histone, cluster member	Homo sapiens	106-118
26303225-14	2015	For the 4439 patients with wild-type BRCA, the cost of maintenance therapy was $444.2M; the ICER was $600,552 per PF-LYS.	Lysine	117-120	BRCA1 DNA repair associated	Homo sapiens	37-41
26303225-14	2015	For the 4439 patients with wild-type BRCA, the cost of maintenance therapy was $444.2M; the ICER was $600,552 per PF-LYS.	Lysine	117-120	cAMP responsive element modulator	Homo sapiens	92-96
15070828-7	2004	Ovine TKDP-3 and bovine TKDP-4 had P1 lysines and inhibited trypsin and plasmin with K(i) values only approximately 10-fold higher than that of BPTI.	Lysine	38-45	trophoblast Kunitz domain protein 4	Bos taurus	24-30
15215206-4	2004	HP1 associates with centric heterochromatin through an interaction with methylated lysine 9 of histone H3, a modification generated by SU(VAR)3-9.	Lysine	83-89	Suppressor of variegation 3-9	Drosophila melanogaster	135-145
16981007-6	2006	An increase in histone H3/H4 acetylation and histone H3 lysine 4 (Lys4) methylation within the Hoxa7 and Hoxa9 promoters provides an epigenetic mechanism by which this overexpression occurs in vivo and an etiologic role for MLL PTD gain of function in the genesis of AML.	Lysine	56-62	homeobox A7	Mus musculus	95-100
25801536-8	2015	By contrast, CBD stimulated mRNA expression of Plod1 in primary osteoblast cultures, encoding an enzyme that catalyzes lysine hydroxylation, which is in turn involved in collagen crosslinking and stabilization.	Lysine	119-125	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Rattus norvegicus	47-52
26358741-4	2015	The synthetic human beta-defensin-2 carrying MeOGly at its N-terminus or the side chain amino group of Lys(10) reacted with phenylisothiocyanate or fluorescein isothiocyanate also at the N-methoxyamino group under the same conditions, demonstrating that this method is generally useful for the site-specific labeling of linear synthetic peptides as well as disulfide-containing peptides.	Lysine	103-106	defensin beta 4B	Homo sapiens	20-35
16849322-6	2006	Structural studies have implicated beta-catenin lysine 19 as the major target for betaTrCP-dependent ubiquitination, but Lys-19 mutations in cancer have not been reported.	Lysine	48-54	catenin beta 1	Homo sapiens	35-47
15245427-4	2004	The heterozygous mutation in codon 42, AAC&gt;AAG, changes asparagine to lysine (N14K).	Lysine	73-79	glycine-N-acyltransferase	Homo sapiens	39-42
16849322-6	2006	Structural studies have implicated beta-catenin lysine 19 as the major target for betaTrCP-dependent ubiquitination, but Lys-19 mutations in cancer have not been reported.	Lysine	48-54	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	82-90
15282304-1	2004	RIZ1 is an estrogen receptor (ER) coactivator but is also a histone lysine methyltransferase that methylates lysine 9 of histone H3, an activity known to repress transcription.	Lysine	68-74	PR/SET domain 2	Homo sapiens	0-4
26251516-8	2015	Mapping Ran sumoylation sites revealed that transport receptors may simply block access of the E2-conjugating enzyme Ubc9, however the acceptor lysines are perfectly accessible in Ran/NTF2 complexes.	Lysine	144-151	nuclear transport factor 2	Homo sapiens	184-188
16849322-7	2006	We studied the consequences of single amino acid substitutions of the only 2 lysine residues in the N-terminal 130 amino acids of beta-catenin.	Lysine	77-83	catenin beta 1	Homo sapiens	130-142
15282304-4	2004	In the presence of estrogen, RIZ1 binding to estrogen target genes became less direct and followed the binding of ER to DNA and RIZ1 methyltransferase activity on H3-Lys 9 was inhibited, indicating derepression may play a role in estrogen induction of gene transcription.	Lysine	166-169	PR/SET domain 2	Homo sapiens	29-33
16849322-8	2006	Mutation of Lys-19 minimally affected beta-catenin levels and functional activity, and mutation of Lys-49 led to reduced beta-catenin levels and function.	Lysine	99-102	catenin beta 1	Homo sapiens	121-133
16849322-9	2006	In contrast, beta-catenin proteins with substitutions at both Lys-19 and Lys-49 positions were present at elevated levels and had the ability to potently activate T cell factor-dependent transcription and promote neoplastic transformation.	Lysine	62-65	catenin beta 1	Homo sapiens	13-25
15339005-6	2004	Graded levels of SAA were supplemented to obtain digestible SAA to Lys ratios of 62, 69, and 77%, with 77% representing an optimized amino acid balance.	Lysine	67-70	serum amyloid A1 cluster	Homo sapiens	17-20
26405459-5	2015	Unlike other PLZF-interacting deacetylases, these two proteins interact with the zinc finger domain of PLZF, where the activating CBP/p300 acetylation site was previously described, inducing deacetylation of lysines 647/650/653.	Lysine	208-215	zinc finger and BTB domain containing 16	Homo sapiens	13-17
26405459-5	2015	Unlike other PLZF-interacting deacetylases, these two proteins interact with the zinc finger domain of PLZF, where the activating CBP/p300 acetylation site was previously described, inducing deacetylation of lysines 647/650/653.	Lysine	208-215	zinc finger and BTB domain containing 16	Homo sapiens	103-107
16849322-9	2006	In contrast, beta-catenin proteins with substitutions at both Lys-19 and Lys-49 positions were present at elevated levels and had the ability to potently activate T cell factor-dependent transcription and promote neoplastic transformation.	Lysine	73-76	catenin beta 1	Homo sapiens	13-25
16849322-11	2006	Our findings suggest that Lys-19 is a primary in vivo site of betaTrCP-dependent ubiquitination and Lys-49 may be a secondary or cryptic site.	Lysine	26-29	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	62-70
16936264-5	2006	The generation of the anti-apoptotic signal on binding of TNF-alpha to the TNF receptor (TNFR)1 has been shown to be associated with the recruitment of TRAF2 to the TNFR1 in a process that requires ubiquitination of TRAF2 with lysine-63-linked polyubiquitin chains.	Lysine	227-233	TNF receptor superfamily member 1A	Homo sapiens	89-95
26031828-3	2015	L-Lysine is known for decades as a precursor for hArg, but only recent studies indicate that arginine:glycine amidinotransferase (AGAT) is responsible for the synthesis of hArg.	Lysine	0-8	glycine amidinotransferase	Homo sapiens	130-134
15184379-1	2004	The breast and ovarian tumor suppressor BRCA1 forms a heterodimeric RING-type ubiquitin ligase with BARD1 to catalyze untraditional Lys-6-linked polyubiquitin chains.	Lysine	132-135	BRCA1 DNA repair associated	Homo sapiens	40-45
15184379-1	2004	The breast and ovarian tumor suppressor BRCA1 forms a heterodimeric RING-type ubiquitin ligase with BARD1 to catalyze untraditional Lys-6-linked polyubiquitin chains.	Lysine	132-135	BRCA1 associated RING domain 1	Homo sapiens	100-105
16936264-5	2006	The generation of the anti-apoptotic signal on binding of TNF-alpha to the TNF receptor (TNFR)1 has been shown to be associated with the recruitment of TRAF2 to the TNFR1 in a process that requires ubiquitination of TRAF2 with lysine-63-linked polyubiquitin chains.	Lysine	227-233	TNF receptor superfamily member 1A	Homo sapiens	165-170
16806697-3	2006	There is evidence that two common polymorphisms of XPD gene (g.22541C>A; exon 6 and g.35931A>C; Lys>Gln; exon 23) may be associated with differential DNA repair activities.	Lysine	96-99	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	51-54
15193993-2	2004	In this study, we investigated the effects of phosphoinositide 3-kinase (PI3K) on ET-1-induced activation of these channels and BA contraction by using PI3K inhibitors, wortmannin and LY 249002.	Lysine	184-186	endothelin-1	Oryctolagus cuniculus	82-86
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	59-62	lymphocyte antigen 96	Homo sapiens	171-175
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	lymphocyte antigen 96	Homo sapiens	171-175
25990136-3	2015	Since it is located in cell nucleus and acts as a histone methylation eraser, LSD1 specifically removes mono- or dimethylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation.	Lysine	137-143	lysine demethylase 1A	Homo sapiens	78-82
25990136-3	2015	Since it is located in cell nucleus and acts as a histone methylation eraser, LSD1 specifically removes mono- or dimethylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation.	Lysine	160-166	lysine demethylase 1A	Homo sapiens	78-82
26026794-2	2015	PDE is caused by deficiency of alpha-aminoadipic semialdehyde dehydrogenase resulting in impaired lysine degradation and subsequent accumulation of alpha-aminoadipic semialdehyde.	Lysine	98-104	aldehyde dehydrogenase 7 family member A1	Homo sapiens	31-75
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	lymphocyte antigen 96	Homo sapiens	171-175
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Lysine	75-78	lymphocyte antigen 96	Homo sapiens	171-175
16824555-5	2006	Subjects with ERCC2 751 Gln/Gln genotype had significantly higher risk of high (above the median) SCE/cell with respect to Lys/Lys referents (OR 4.55, 95% CI 1.48-13.99).	Lysine	123-126	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	14-19
15111623-8	2004	In contrast, mutation of another basic cluster composed of Arg(69)-Lys(72), which according to the model lies further apart from the hydrophobic pocket only weakly decreased MD-2 activity.	Lysine	67-70	lymphocyte antigen 96	Homo sapiens	174-178
15252442-4	2004	By immunofluorescence and chromatin immunoprecipitation experiments we show that histone H3 lysine 27 trimethylation (H3K27m3) and H4 lysine 20 monomethylation (H4K20m1) are associated with Xist expression in undifferentiated ES cells and mark the initiation of X inactivation.	Lysine	92-98	inactive X specific transcripts	Mus musculus	190-194
26046922-6	2015	Furthermore, lots of nutrient-storage proteins, such as apolipophorin, vitellogenin, storage proteins, and 30 K proteins, were highly acetylated, indicating lysine acetylation may represent a common regulatory mechanism of nutrient utilization in the silkworm.	Lysine	157-163	vitellogenin	Bombyx mori	71-83
26046922-7	2015	Interestingly, Ser2 proteins, the coating proteins of larval silk, were found to contain many Kac sites, suggesting lysine acetylation may be involved in the regulation of larval silk synthesis.	Lysine	116-122	sericin 2	Bombyx mori	15-19
16824555-5	2006	Subjects with ERCC2 751 Gln/Gln genotype had significantly higher risk of high (above the median) SCE/cell with respect to Lys/Lys referents (OR 4.55, 95% CI 1.48-13.99).	Lysine	127-130	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	14-19
15209497-5	2004	To fix the distance between the C-terminal end of the A chain and Trp (B27) at predetermined lengths, we synthesized RLF with covalent cross-links between a lysine, which was placed in position B26, and the alpha-carboxyl group at the C terminus of the A chain (A26).	Lysine	157-163	RLF zinc finger	Homo sapiens	117-120
16803875-5	2006	In addition to a conserved RNA recognition motif and a C-terminal RNA binding domain, wheat eIF4B contains a novel N-terminal RNA binding domain that requires a short, lysine-rich containing sequence.	Lysine	168-174	eukaryotic translation initiation factor 4B1	Triticum aestivum	92-97
15210726-2	2004	We show that Elk-1 is also conjugated to SUMO on either lysines 230, 249, or 254.	Lysine	56-63	ETS transcription factor ELK1	Homo sapiens	13-18
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Lysine	52-55	spleen trypsin inhibitor I	Bos taurus	183-187
26249842-8	2015	In addition, combined use of simulations and phylogenetic analysis has helped in the discovery of a new subfamily of Fic proteins that harbor a conserved Lys/Arg in place of the inhibitory Glu of the regulatory helix.	Lysine	154-157	C-C motif chemokine ligand 7	Homo sapiens	117-120
16803875-6	2006	Both the lysine-rich motif and an adjacent, C-proximal motif are conserved with an N-proximal sequence in human and yeast eIF4B.	Lysine	9-15	eukaryotic translation initiation factor 4B1	Triticum aestivum	122-127
15152190-4	2004	SIRT1 physically interacts with the RelA/p65 subunit of NF-kappaB and inhibits transcription by deacetylating RelA/p65 at lysine 310.	Lysine	122-128	sirtuin 1	Homo sapiens	0-5
16828048-3	2006	Limited proteolysis of MAB007 with Lys-C led to a single cleavage at the C-terminus of a lysine residue in the hinge region of the heavy chain at position 222, generating free Fab and Fc fragments.	Lysine	89-95	FA complementation group B	Homo sapiens	176-179
16882721-1	2006	The Rtf1 subunit of the Paf1 complex is required for proper monoubiquitination of histone H2B and methylation of histone H3 on lysines 4 (H3K4) and 79 in yeast Saccharomyces cerevisiae.	Lysine	127-134	Rtf1p	Saccharomyces cerevisiae S288C	4-8
15158327-9	2004	Sequence analysis of hepcidin amplicons from DBA/2N mice predicted an Asn--&gt;Lys substitution at position 73 of the HAMP peptide and a Ser--&gt;Phe substitution at position 76 of the HAMP2 peptide.	Lysine	79-82	hepcidin antimicrobial peptide	Mus musculus	21-29
15169878-6	2004	Chromatin immunoprecipitation assays showed that treatment of cells with TSA or silencing of HDAC3 expression by small interfering RNA causes the hyperacetylation of Lys-9 in histone H3 on the gdf11 promoter.	Lysine	166-169	growth differentiation factor 11	Homo sapiens	193-198
26157143-4	2015	In this study, we have shown that due to the site-specific Lys to Ala mutations of PIP5K at Lys-244 and Lys-490, it is unable to localize in the nucleus and nucleolus, respectively.	Lysine	59-62	phosphoinositide kinase, FYVE-type zinc finger containing	Homo sapiens	83-88
26157143-4	2015	In this study, we have shown that due to the site-specific Lys to Ala mutations of PIP5K at Lys-244 and Lys-490, it is unable to localize in the nucleus and nucleolus, respectively.	Lysine	92-95	phosphoinositide kinase, FYVE-type zinc finger containing	Homo sapiens	83-88
26157143-4	2015	In this study, we have shown that due to the site-specific Lys to Ala mutations of PIP5K at Lys-244 and Lys-490, it is unable to localize in the nucleus and nucleolus, respectively.	Lysine	92-95	phosphoinositide kinase, FYVE-type zinc finger containing	Homo sapiens	83-88
26157143-7	2015	Moreover, the immunoprecipitation results clearly demonstrate that PIP5K SUMOylated at Lys-490 interacts with components of the chromatin silencing machinery, H3K9me3 and heterochromatin protein 1alpha.	Lysine	87-90	phosphoinositide kinase, FYVE-type zinc finger containing	Homo sapiens	67-72
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	squalene epoxidase	Mus musculus	129-133
16882982-7	2006	Our analyses of mutants that lack the PcG histone methyltransferase (HMTase) E(z) or the trxG HMTase Ash1 provide strong evidence that differential histone lysine trimethylation at the promoter and in the coding region confers transcriptional ON and OFF states of Ubx.	Lysine	156-162	absent, small, or homeotic discs 1	Drosophila melanogaster	101-105
26267652-7	2015	Changes at histone-3 lysine-27 acetylation (H3K27ac) marks were detected at genes Fasn, Nr3c1, and Plin5.	Lysine	21-27	perilipin 5	Mus musculus	99-104
15128807-0	2004	Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H.	Lysine	0-6	complement factor H	Homo sapiens	126-134
15128807-6	2004	Alanine substitution of amino acids in peptides from the key binding regions of the OspE family indicated that several lysine residues are required for factor H binding.	Lysine	119-125	complement factor H	Homo sapiens	152-160
15128807-7	2004	Thus, the borrelial OspE family proteins bind the C inhibitor factor H via multiple sites in a lysine-dependent manner.	Lysine	95-101	complement factor H	Homo sapiens	62-70
14665632-5	2004	Although the p33ING1-Sin3-HDAC and DMAP1-DNMT1 complexes are recruited independently to pericentric heterochromatin regions, they are both required for deacetylation of histones and methylation of histone H3 at lysine 9.	Lysine	211-217	DNA methyltransferase 1	Homo sapiens	41-46
16675445-5	2006	However, recruitment of RNA polymerase II to the coding sequence of a galactose-inducible gene, GAL1, is significantly reduced in the absence of H2B-Lys-123 ubiquitination but not H3-Lys-4 methylation.	Lysine	149-152	galectin 1	Homo sapiens	96-100
15086792-8	2004	We also identified multiple (five) lysine residues in the linker that are important for Ste6p ubiquitination.	Lysine	35-41	ATP-binding cassette a-factor transporter STE6	Saccharomyces cerevisiae S288C	88-93
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	SCC	Bos taurus	166-169
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	SCS	Bos taurus	175-193
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	SCS	Bos taurus	195-198
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	SCC	Bos taurus	270-273
26154111-6	2015	A novel SNP (g.39645396A&gt;G) in JAK2 was predicted to change the amino acid from lysine to asparagine and was significantly associated with the somatic cell count (SCC) and somatic cell score (SCS), whereas g.43673888A&gt;G in STAT5B was significantly associated with SCC, SCS and interleukin-4 (IL-4) (P &lt; 0.05).	Lysine	83-89	SCS	Bos taurus	275-278
26161728-3	2015	Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799).	Lysine	112-115	ubiquitin protein ligase E3A	Homo sapiens	71-75
14983021-1	2004	We recently used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait locus (QTL) affecting milk fat composition, previously mapped to the centromeric end of bovine chromosome 14.	Lysine	77-83	diacylglycerol O-acyltransferase 1	Bos taurus	130-135
14660634-2	2004	Given the requirement of Rad6/Bre1-dependent ubiquitination of histone H2B for H3 dimethylation (at lysines 4 and 79) and gene silencing (2-7), removal of ubiquitin from H2B may have a significant regulatory effect on transcription.	Lysine	100-107	histone H2B	Saccharomyces cerevisiae S288C	63-74
14660634-7	2004	Furthermore, trimethylation of H3 at lysine 4 within the UAS increases significantly under activating conditions, and remarkably, Ubp8 is shown to have a role in regulating the methylation status of this residue.	Lysine	37-43	ubiquitin-specific protease UBP8	Saccharomyces cerevisiae S288C	130-134
16675455-4	2006	Previous structural studies predicted the Lys-205 residue of eEF1B alpha plays an important role in promoting nucleotide exchange by disrupting the Mg2+ binding site.	Lysine	42-45	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	61-66
16675455-8	2006	These results indicate the significant role of Mg2+ in the nucleotide exchange reaction by eEF1B alpha and establish the catalytic function of Lys-205 in displacing Mg2+ from its binding site.	Lysine	143-146	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	91-96
16713291-9	2006	Interestingly, next to in the binding interface expected lysines, K89 and K97, two from the crystal structure data unexpected lysines, K81 and K76, were observed to become less exposed upon Im9 binding.	Lysine	126-133	keratin 76	Homo sapiens	143-146
14647440-7	2003	Chromatin immunoprecipitation assay revealed that histone H3 lysine 9 was hypermethylated throughout the island in the MGMT negative line, whereas acetylation on H3 and H4 and methylation on H3 lysine 4 were at significantly high levels outside the minimal promoter in the MGMT-expressed line.	Lysine	61-67	O-6-methylguanine-DNA methyltransferase	Homo sapiens	119-123
26161728-3	2015	Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799).	Lysine	125-128	ubiquitin protein ligase E3A	Homo sapiens	71-75
26161728-5	2015	Thus, opposing roles of Lys(799) and Lys(847) pave the path forward to pharmacological inhibitors or activators of E6AP for therapeutic purposes.	Lysine	24-27	ubiquitin protein ligase E3A	Homo sapiens	115-119
26161728-5	2015	Thus, opposing roles of Lys(799) and Lys(847) pave the path forward to pharmacological inhibitors or activators of E6AP for therapeutic purposes.	Lysine	37-40	ubiquitin protein ligase E3A	Homo sapiens	115-119
12949144-7	2003	In both species, the isopeptide bond is formed between lysine 118 of the actin and the C-terminal glycine 76 of ubiquitin.	Lysine	55-61	Ribosomal protein S27A	Drosophila melanogaster	112-121
16799550-4	2006	The anaphase-promoting complex was found to attach monoubiquitin to multiple lysine residues on cyclin B1, followed by poly-ubiquitin chain extensions linked through multiple lysine residues of ubiquitin (Lys 63, Lys 11 and Lys 48).	Lysine	77-83	cyclin B1	Homo sapiens	96-105
14630972-6	2003	These loops, which are enlarged in nuclei of mature ddm1 plants, are enriched for histone H3 acetylated at Lys-9 and methylated at Lys-4 compared with the heterochromatic chromocenters.	Lysine	107-110	chromatin remodeling 1	Arabidopsis thaliana	52-56
14630972-6	2003	These loops, which are enlarged in nuclei of mature ddm1 plants, are enriched for histone H3 acetylated at Lys-9 and methylated at Lys-4 compared with the heterochromatic chromocenters.	Lysine	131-134	chromatin remodeling 1	Arabidopsis thaliana	52-56
25337983-2	2015	Important model peptides for the study of the coil-to-helix transition have been alanine-lysine (AKA) peptides in which the lysine residues are placed on opposite sides of the helix avoiding charge repulsion while enhancing solubility.	Lysine	89-95	neurogenin 1	Homo sapiens	97-100
25337983-2	2015	Important model peptides for the study of the coil-to-helix transition have been alanine-lysine (AKA) peptides in which the lysine residues are placed on opposite sides of the helix avoiding charge repulsion while enhancing solubility.	Lysine	124-130	neurogenin 1	Homo sapiens	97-100
26195665-2	2015	The BRCC36 isopeptidase complex (BRISC) is a DUB that is specific for lysine 63-linked ubiquitin hydrolysis; however, its biological function remains largely undefined.	Lysine	70-76	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	4-10
16636056-0	2006	Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.	Lysine	38-41	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	Mus musculus	6-9
25920949-8	2015	RESULTS: Study reveals potent selective molecules that interact and form hydrogen bonds with amino acids Ser-6 and Lys-22 are common to established melatonin inhibitors for MT-III.	Lysine	115-118	metallothionein 3	Homo sapiens	173-179
14613109-10	2003	Preliminary nuclear medicine studies on cell lines transfected with the CCK(A) receptor indicate that the sulfated-Tyr derivative of cyclo(29,34)[Dpr(29),Lys(34)]-CCK8 displaces the natural ligand with an IC(50) value of 15 microM.	Lysine	154-157	cholecystokinin A receptor	Homo sapiens	72-87
16636056-2	2006	We previously identified Dot1a as an aldosterone early repressed gene and a repressor of ENaCalpha transcription through mediating histone H3 Lys-79 methylation associated with the ENaCalpha promoter.	Lysine	142-145	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	89-98
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Lysine	179-185	ciliary neurotrophic factor	Homo sapiens	18-45
25979266-7	2015	This chromatin stabilization requires the lysine-rich C-terminal extension of HMO1 as truncation of the HMO1 C-terminal tail phenocopies hmo1 deletion.	Lysine	42-48	Hmo1p	Saccharomyces cerevisiae S288C	78-82
25979266-7	2015	This chromatin stabilization requires the lysine-rich C-terminal extension of HMO1 as truncation of the HMO1 C-terminal tail phenocopies hmo1 deletion.	Lysine	42-48	Hmo1p	Saccharomyces cerevisiae S288C	104-108
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Lysine	179-185	ciliary neurotrophic factor	Homo sapiens	47-51
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Lysine	179-185	ciliary neurotrophic factor	Homo sapiens	206-210
16636056-2	2006	We previously identified Dot1a as an aldosterone early repressed gene and a repressor of ENaCalpha transcription through mediating histone H3 Lys-79 methylation associated with the ENaCalpha promoter.	Lysine	142-145	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	181-190
16636056-5	2006	Overexpression of AF9 results in hypermethylation of histone H3 Lys-79 at the endogenous ENaCalpha promoter at most, but not all subregions examined, repression of endogenous ENaCalpha mRNA expression and acts synergistically with Dot1a to inhibit ENaCalpha promoter-luciferase constructs.	Lysine	64-67	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	Mus musculus	18-21
14510671-4	2003	In the present study, the effects of a 5"-polymorphism of TG and of a lysine/alanine polymorphism of DGAT1 on the fat content of musculus (m.) semitendinosus and m. longissimus dorsi in 55 bovine animals (28 German Holstein and 27 Charolais) has been investigated.	Lysine	70-76	diacylglycerol O-acyltransferase 1	Bos taurus	101-106
16636056-9	2006	Thus, Dot1a-AF9 modulates histone H3 Lys-79 methylation at the ENaCalpha promoter and represses ENaCalpha transcription in an aldosterone-sensitive manner.	Lysine	37-40	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	Mus musculus	12-15
25979266-7	2015	This chromatin stabilization requires the lysine-rich C-terminal extension of HMO1 as truncation of the HMO1 C-terminal tail phenocopies hmo1 deletion.	Lysine	42-48	Hmo1p	Saccharomyces cerevisiae S288C	137-141
16636056-9	2006	Thus, Dot1a-AF9 modulates histone H3 Lys-79 methylation at the ENaCalpha promoter and represses ENaCalpha transcription in an aldosterone-sensitive manner.	Lysine	37-40	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	63-72
25979266-8	2015	Since this is reminiscent of the need for the basic C-terminal domain of mammalian histone H1 in chromatin compaction, we speculate that HMO1 promotes chromatin stability by DNA bending and compaction imposed by its lysine-rich domain and that it must be evicted along with core histones for efficient DSB repair.	Lysine	216-222	Hmo1p	Saccharomyces cerevisiae S288C	137-141
16627470-0	2006	An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.	Lysine	89-95	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	131-137
26140605-4	2015	Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.	Lysine	0-6	LDL receptor related protein 6	Homo sapiens	72-76
12968876-3	2003	They are found to be stable for several months when stored at 4 degrees C. The acyl azides of Asp, Glu, Ser, Tyr, and Lys with side-chain protection having tert-butyl, benzyl, and Boc groups were also converted to the corresponding isocyanates 2h-m.	Lysine	118-121	BOC cell adhesion associated, oncogene regulated	Homo sapiens	180-183
16627470-3	2006	We investigated the effect on expression and function of the Lys --&gt; Met mutation in mouse alpha1(K278M), beta2(K274M), and gamma2(K289M) subunits.	Lysine	61-64	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	127-133
16728273-1	2006	OBJECTIVE: Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein half-life in vivo.	Lysine	88-94	erythropoietin	Rattus norvegicus	11-25
12890688-0	2003	The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.	Lysine	103-109	BRCA1 DNA repair associated	Homo sapiens	4-9
12890688-0	2003	The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.	Lysine	103-109	BRCA1 associated RING domain 1	Homo sapiens	10-15
12890688-6	2003	In contrast, however, the BRCA1/BARD1 heterodimer directs polymerization of ubiquitin primarily through an unconventional linkage involving lysine residue K6.	Lysine	140-146	BRCA1 DNA repair associated	Homo sapiens	26-31
12890688-6	2003	In contrast, however, the BRCA1/BARD1 heterodimer directs polymerization of ubiquitin primarily through an unconventional linkage involving lysine residue K6.	Lysine	140-146	BRCA1 associated RING domain 1	Homo sapiens	32-37
26440016-6	2015	The incorporation of SPC raised the available CP from 49.1 g/kg DM (1.91 g total Lys/kg DM) in AK up to 135 g/kg DM (7.24 g total Lys/kg DM).	Lysine	81-84	surfactant protein C	Sus scrofa	21-24
26440016-6	2015	The incorporation of SPC raised the available CP from 49.1 g/kg DM (1.91 g total Lys/kg DM) in AK up to 135 g/kg DM (7.24 g total Lys/kg DM).	Lysine	130-133	surfactant protein C	Sus scrofa	21-24
26440016-11	2015	The lowest daily intake of total Lys resulting in maximum PD (69.5 g/d) at the fixed level of energy intake observed (2.36 x ME maintenance requirements) was 21.0 g. Hot carcass and cold carcass weights, but not carcass yield, increased when feeding the daily ration containing 100 g SPC and leveled off thereafter (linear, P &lt; 0.01; quadratic, P &lt; 0.01).	Lysine	33-36	surfactant protein C	Sus scrofa	284-287
16728273-1	2006	OBJECTIVE: Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein half-life in vivo.	Lysine	88-94	erythropoietin	Rattus norvegicus	27-30
16432806-2	2006	By internal acylation of Lys, Orn, L-1,4-diaminobutyric acid (Dab), L-1,3-diaminopropionic acid (Dap) at position 4 with the C-terminal Gly of the peptide tail, we prepared cyclo-(4-9)-[Lys(4), Gly(9)]-PA (pA(2) = 8.77 +/- 0.27), 1, and cyclo-(4-9)-[Orn(4), Gly(9)]-PA (pA(2) = 8.81 +/- 0.25), 3, which are equipotent with PA (pA(2) = 8.68 +/- 0.18) in the rat uterotonic assay and cyclo-(4-9)-[Dab(4), Gly(9)]-PA, 4, cyclo-(4-9)-[Dap(4), Gly(9)]-PA, 5, and cyclo-(4-9)-[Pmp(1), Lys(4), Gly(9)]-PA, 2, which were weaker OTAs.	Lysine	25-28	death-associated protein	Rattus norvegicus	97-100
25878105-4	2015	Three ASYMP CD8(+) T-cell epitopes (gD(53-61), gD(70-78), and gD(278-286)) were linked with a promiscuous CD4(+) T-cell epitope (gD(287-317)) to create 3 separate pairs of CD4-CD8 peptides, which were then each covalently coupled to an Nepsilon-palmitoyl-lysine moiety, a Toll-like receptor 2 (TLR-2) ligand.	Lysine	255-261	CD8a molecule	Homo sapiens	12-15
25755154-7	2015	We show that the interactions between Cyc1p and Erv1p, and between Cyc1p and Cyc3p, are significantly increased upon trimethylation of lysine 78.	Lysine	135-141	holocytochrome c synthase CYC3	Saccharomyces cerevisiae S288C	77-82
12944473-4	2003	The MENT distribution profile was opposite to that of acetylated core histones but correlated with that of histone H3 dimethylated at lysine 9 (H3me2K9).	Lysine	134-140	predicted gene 128	Mus musculus	4-8
12944473-8	2003	In vitro, the elimination of the histone H3 N-terminal peptide containing lysine 9 by trypsin blocked chromatin self-association by MENT, while reconstitution with dimethylated but not acetylated N-terminal domain of histone H3 specifically restored chromatin self-association by MENT.	Lysine	74-80	predicted gene 128	Mus musculus	132-136
12944473-8	2003	In vitro, the elimination of the histone H3 N-terminal peptide containing lysine 9 by trypsin blocked chromatin self-association by MENT, while reconstitution with dimethylated but not acetylated N-terminal domain of histone H3 specifically restored chromatin self-association by MENT.	Lysine	74-80	predicted gene 128	Mus musculus	280-284
12944473-9	2003	We suggest that histone H3 modification at lysine 9 directly regulates chromatin condensation by recruiting MENT to chromatin in a fashion that is spatially constrained from active genes by gene boundary elements and histone hyperacetylation.	Lysine	43-49	predicted gene 128	Mus musculus	108-112
16432806-2	2006	By internal acylation of Lys, Orn, L-1,4-diaminobutyric acid (Dab), L-1,3-diaminopropionic acid (Dap) at position 4 with the C-terminal Gly of the peptide tail, we prepared cyclo-(4-9)-[Lys(4), Gly(9)]-PA (pA(2) = 8.77 +/- 0.27), 1, and cyclo-(4-9)-[Orn(4), Gly(9)]-PA (pA(2) = 8.81 +/- 0.25), 3, which are equipotent with PA (pA(2) = 8.68 +/- 0.18) in the rat uterotonic assay and cyclo-(4-9)-[Dab(4), Gly(9)]-PA, 4, cyclo-(4-9)-[Dap(4), Gly(9)]-PA, 5, and cyclo-(4-9)-[Pmp(1), Lys(4), Gly(9)]-PA, 2, which were weaker OTAs.	Lysine	25-28	death-associated protein	Rattus norvegicus	431-434
12747801-3	2003	We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys(322) and Lys(328), located in the third baculovirus IAP repeat domain of the protein.	Lysine	81-84	X-linked inhibitor of apoptosis	Homo sapiens	57-69
16565295-13	2006	In this perspective, it is notable that the Lys-rich segment in Cor47 and Lti29 shows sequence similarity with the animal chaperone HSP90.	Lysine	44-47	cold-regulated 47	Arabidopsis thaliana	64-69
12747801-3	2003	We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys(322) and Lys(328), located in the third baculovirus IAP repeat domain of the protein.	Lysine	81-84	X-linked inhibitor of apoptosis	Homo sapiens	71-75
12747801-3	2003	We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys(322) and Lys(328), located in the third baculovirus IAP repeat domain of the protein.	Lysine	94-97	X-linked inhibitor of apoptosis	Homo sapiens	57-69
12747801-3	2003	We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys(322) and Lys(328), located in the third baculovirus IAP repeat domain of the protein.	Lysine	94-97	X-linked inhibitor of apoptosis	Homo sapiens	71-75
12897052-3	2003	A similar mechanism in heterochromatin assembly is mediated by HP1, a chromodomain protein that binds to histone H3 methylated at Lys 9.	Lysine	130-133	Heterochromatin Protein 1c	Drosophila melanogaster	63-66
12759344-9	2003	Interestingly, PML mutants in which sumoylation at lysine 160 was inhibited displayed an increased association with MDM2, suggesting that sumoylation at this site may be a determinant of PML-MDM2 binding.	Lysine	51-57	MDM2 proto-oncogene	Homo sapiens	116-120
26029848-5	2015	The interaction of PAM with Plg is believed to be mediated by lysine binding sites within kringle (KR) 2 of Plg.	Lysine	62-68	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	19-22
26029848-6	2015	PAM-GI-Plg interactions were fully inhibited with 100 mM lysine analogue epsilon-aminocaproic acid (epsilonACA), whereas PAM-GII-Plg interactions were shown to be weakened but not inhibited in the presence of 400 mM epsilonACA.	Lysine	57-63	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	0-3
25944903-5	2015	Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32.	Lysine	16-22	F-box protein 32	Homo sapiens	111-117
25911107-0	2015	Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity.	Lysine	51-57	major histocompatibility complex, class I, C	Homo sapiens	81-99
25911107-6	2015	Biomechanical studies revealed that lysine acetylation significantly decreased the Km for the actin-activated ATPase activity of MHC isoforms.	Lysine	36-42	major histocompatibility complex, class I, C	Homo sapiens	129-132
12759344-9	2003	Interestingly, PML mutants in which sumoylation at lysine 160 was inhibited displayed an increased association with MDM2, suggesting that sumoylation at this site may be a determinant of PML-MDM2 binding.	Lysine	51-57	MDM2 proto-oncogene	Homo sapiens	191-195
16565295-13	2006	In this perspective, it is notable that the Lys-rich segment in Cor47 and Lti29 shows sequence similarity with the animal chaperone HSP90.	Lysine	44-47	Dehydrin family protein	Arabidopsis thaliana	74-79
16719461-5	2006	The least reactive lysines in adsorbed cytochrome c were found to be 13, 72, 73, 79, and 86-88, consistent with a contact region located up and to the left (Met-80 side) of the solvent-exposed heme edge (conventional front face view).	Lysine	19-26	cytochrome c, somatic	Equus caballus	39-51
12867036-0	2003	Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.	Lysine	26-32	sirtuin 1	Homo sapiens	0-4
12867036-5	2003	Here, we show that spSir2, the S. pombe Sir2-like protein that is the most closely related to the S. cerevisiae Sir2, is an NAD(+)-dependent deacetylase that efficiently deacetylates histone H3 lysine 9 (K9) and histone H4 lysine 16 (K16) in vitro.	Lysine	194-200	sirtuin 1	Homo sapiens	21-25
12867036-5	2003	Here, we show that spSir2, the S. pombe Sir2-like protein that is the most closely related to the S. cerevisiae Sir2, is an NAD(+)-dependent deacetylase that efficiently deacetylates histone H3 lysine 9 (K9) and histone H4 lysine 16 (K16) in vitro.	Lysine	194-200	sirtuin 1	Homo sapiens	40-44
12867036-5	2003	Here, we show that spSir2, the S. pombe Sir2-like protein that is the most closely related to the S. cerevisiae Sir2, is an NAD(+)-dependent deacetylase that efficiently deacetylates histone H3 lysine 9 (K9) and histone H4 lysine 16 (K16) in vitro.	Lysine	223-229	sirtuin 1	Homo sapiens	21-25
25893304-6	2015	Mechanistically, LSD1 promotes beta-catenin activation by inhibiting the expression of several suppressors of beta-catenin signaling, especially Prickle1 and APC in Lgr5(+) CICs, by directly regulating the levels of mono- and di-methylation of histone H3 lysine-4 at the promoters of these genes.	Lysine	255-261	lysine demethylase 1A	Homo sapiens	17-21
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	lysine demethylase 1A	Homo sapiens	44-48
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	lysine demethylase 1A	Homo sapiens	49-54
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	DNA methyltransferase 1	Homo sapiens	72-77
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	DNA methyltransferase 1	Homo sapiens	126-131
25753001-7	2015	In addition, lysine-specific demethylase 1 (LSD1/KDM1A), a regulator of DNMT1 stability, was identified as a component of the Dnmt1-beta-catenin protein complex and perturbation of the Dnmt1-beta-catenin interaction altered DNA methylation.	Lysine	13-19	DNA methyltransferase 1	Homo sapiens	185-190
12690118-10	2003	(iii) Mutation of residues IL3 points to the specific role of lysine 322 in the efficacy of the stimulation of AC activity by VIP.	Lysine	62-68	VIP peptides	Cricetulus griseus	126-129
16648462-0	2006	SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.	Lysine	62-65	sirtuin 2	Homo sapiens	0-5
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Lysine	121-124	melanocortin 1 receptor	Homo sapiens	168-198
12662153-10	2003	Our data revealed further the critical role of the last two basic amino acid residues (e.g. Lys(82)-Arg(83) for the mouse PC1/3 sequence) of the prodomain in imparting a strong anti-convertase activity.	Lysine	92-95	proprotein convertase subtilisin/kexin type 1	Mus musculus	122-127
25770209-3	2015	The positive charge on two of these lysines, Lys(49) and Lys(120), is critical for coordinating 14-3-3zeta-phosphoprotein interactions.	Lysine	36-43	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	96-106
25770209-3	2015	The positive charge on two of these lysines, Lys(49) and Lys(120), is critical for coordinating 14-3-3zeta-phosphoprotein interactions.	Lysine	45-48	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	96-106
25770209-3	2015	The positive charge on two of these lysines, Lys(49) and Lys(120), is critical for coordinating 14-3-3zeta-phosphoprotein interactions.	Lysine	57-60	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	96-106
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Lysine	121-124	melanocortin 1 receptor	Homo sapiens	200-205
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
12820891-9	2003	The coplanar system between the electronegative tip and guanidine-amidine moiety extends the conjugation and facilitates negative charge (delta(-)) flow toward the tip, thereby enhancing interaction with the proposed cationic subsite such as lysine or arginine in the Drosophila nAChR.	Lysine	242-248	nicotinic Acetylcholine Receptor beta1	Drosophila melanogaster	279-284
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	230-233	coactivator associated arginine methyltransferase 1	Homo sapiens	106-111
16549805-2	2006	In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination of Lys-156 and Lys-158 in Insig-1.	Lysine	117-120	insulin induced gene 1	Homo sapiens	25-32
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Lysine	242-245	coactivator associated arginine methyltransferase 1	Homo sapiens	106-111
12887910-3	2003	These genes are surrounded by Lys-9-methylated H3 histones, and their promoters are occupied by the pRb-related protein p130 and the inhibitory transcription factor E2F4.	Lysine	30-33	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	120-124
12887910-4	2003	Kinetic analysis indicates that E1A binds to E2F promoters where it eliminates p130 and E2F4, resulting in the dramatic elimination of H3 Lys-9 methylation.	Lysine	138-141	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	79-83
25477280-2	2015	Only the combined loss of EZH1 and EZH2 in mouse hepatocytes caused a depletion of global trimethylation on Lys 27 of histone H3 (H3K27me3) marks and the specific loss of over ~1900 genes at 3 mo of age.	Lysine	108-111	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	35-39
16549805-2	2006	In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination of Lys-156 and Lys-158 in Insig-1.	Lysine	129-132	insulin induced gene 1	Homo sapiens	25-32
16288599-3	2006	A. suum cytochrome b5 is a basic protein containing more lysine residues and exhibiting a higher midpoint redox potential than its mammalian counterparts.	Lysine	57-63	cytochrome b5 type A	Homo sapiens	8-21
25786853-7	2015	We found that reducing the levels of histone H4 lysine 16 acetylation or H3 lysine 79 methylation partially suppresses these sensitivities and reduces spontaneous and genotoxin-induced activation of the DNA damage-response kinase Rad53 in hst3  hst4  cells.	Lysine	48-54	NAD-dependent histone deacetylase HST4	Saccharomyces cerevisiae S288C	245-249
12733060-4	2003	In this work, we demonstrated that the NFO3 gene is identical to OLE1 and that the nfo3-1 mutation (renamed ole1-101) alters arginine-346, in the vicinity of the conserved histidine-rich motif essential for the catalytic function of the Ole1 protein, to lysine.	Lysine	254-260	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	108-112
12750254-5	2003	p29ING4 and p28ING5 enhance p53 acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and p53 in vivo.	Lysine	47-50	inhibitor of growth family member 4	Homo sapiens	0-7
16288599-11	2006	The charge distribution around the haem crevice of A. suum cytochrome b5 is remarkably different from that of mammalian cytochrome b5 in that the nematode protein bears positively charged lysine residues surrounding the haem crevice.	Lysine	188-194	cytochrome b5 type A	Homo sapiens	59-72
16356933-8	2006	Opposing the actions of HDAC4 and Cdk5, calcineurin (also known as protein phosphatase 2B) dephosphorylated Ser-444 and inhibited sumoylation of Lys-439.	Lysine	145-148	cyclin dependent kinase 5	Homo sapiens	34-38
26020318-9	2015	The ADG showed a quadratic increase ( P= 0.02), as the SID Leu:Lys level increased from 0.70 to 0.90 SID Leu:Lys and did not change further from 0.90 to 1.20 SID Leu:Lys.	Lysine	63-66	ADG	Sus scrofa	4-7
26020318-9	2015	The ADG showed a quadratic increase ( P= 0.02), as the SID Leu:Lys level increased from 0.70 to 0.90 SID Leu:Lys and did not change further from 0.90 to 1.20 SID Leu:Lys.	Lysine	109-112	ADG	Sus scrofa	4-7
26020318-9	2015	The ADG showed a quadratic increase ( P= 0.02), as the SID Leu:Lys level increased from 0.70 to 0.90 SID Leu:Lys and did not change further from 0.90 to 1.20 SID Leu:Lys.	Lysine	109-112	ADG	Sus scrofa	4-7
12606556-10	2003	These results suggest that inactivating cleavages catalyzed by factor Xa at Lys(36) and Arg(336) are regulated in part by the A3-C1-C2 subunit.	Lysine	76-79	coagulation factor X	Homo sapiens	63-72
12606556-11	2003	Furthermore, cleavage at Lys(36) appears to be selectively modulated by the C-terminal acidic region of A1, a region that may interact with factor Xa via its heparin-binding exosite.	Lysine	25-28	coagulation factor X	Homo sapiens	140-149
16215985-0	2006	The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.	Lysine	48-54	ring finger protein 8	Homo sapiens	24-28
12718547-0	2003	Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha.	Lysine	18-24	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	86-131
12718547-4	2003	Removing the side chain of lysine 122 compromises the catalytic ability of CCTalpha, decreasing the apparent V(max) value in mutant enzymes Lys122Ala and Lys122Arg to 0.30 and 0.09% of the wild-type value, respectively.	Lysine	27-33	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	75-83
12718547-8	2003	These data suggest lysine 122 and arginine 196 of rat CTP:phosphocholine cytidylyltransferase are functionally important amino acids, perhaps at or near the active site involved in forming contacts with the substrates phosphocholine and CTP, respectively.	Lysine	19-25	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	54-93
25823821-2	2015	Here we report that Shp2 is modified by SUMO1 at lysine residue 590 (K590) in its C-terminus, which is reduced by SUMO1-specific protease SENP1.	Lysine	49-55	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	20-24
16215985-0	2006	The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.	Lysine	48-54	ubiquitin conjugating enzyme E2 N	Homo sapiens	38-43
16215985-1	2006	The heterodimeric ubiquitin conjugating enzyme (E2) UBC13-UEV mediates polyubiquitylation through lysine 63 of ubiquitin (K63), rather than lysine 48 (K48).	Lysine	98-104	ubiquitin conjugating enzyme E2 N	Homo sapiens	52-57
16376303-1	2006	Mouse ARD1 (mARD1) has been reported to negatively regulate the hypoxia-inducible factor 1alpha (HIF-1alpha) protein by acetylating a lysine residue and enhancing HIF-1alpha ubiquitination and degradation.	Lysine	134-140	N(alpha)-acetyltransferase 10, NatA catalytic subunit	Mus musculus	12-17
25662202-2	2015	Ten-eleven translocation (Tet1), a key regulator of DNA methylation, has been identified as a key enzyme for the activation of DNA demethylation; histone H3 lysine 9 (H3K9) and 27 (H3K27) methylation repress gene expression.	Lysine	157-163	methylcytosine dioxygenase TET1	Capra hircus	26-30
25866881-5	2015	The PB1-F2 sequence alignment revealed a cluster of lysines on the carboxy terminal end of PB1-F2 in almost all of the GenBank sequences available to date.	Lysine	52-59	submaxillary gland androgen regulated protein 3A	Homo sapiens	4-7
12629650-6	2003	A heterozygous SNP, Lys 29 (AAG) --&gt; Met (ATG), was found in the intracellular adhesion molecule-1 (ICAM-1) (receptor for rhinoviruses and some coxsackie A viruses) in one individual in both groups.	Lysine	20-23	N-methylpurine DNA glycosylase	Homo sapiens	28-31
12629650-6	2003	A heterozygous SNP, Lys 29 (AAG) --&gt; Met (ATG), was found in the intracellular adhesion molecule-1 (ICAM-1) (receptor for rhinoviruses and some coxsackie A viruses) in one individual in both groups.	Lysine	20-23	intercellular adhesion molecule 1	Homo sapiens	68-101
12629650-6	2003	A heterozygous SNP, Lys 29 (AAG) --&gt; Met (ATG), was found in the intracellular adhesion molecule-1 (ICAM-1) (receptor for rhinoviruses and some coxsackie A viruses) in one individual in both groups.	Lysine	20-23	intercellular adhesion molecule 1	Homo sapiens	103-109
25866881-5	2015	The PB1-F2 sequence alignment revealed a cluster of lysines on the carboxy terminal end of PB1-F2 in almost all of the GenBank sequences available to date.	Lysine	52-59	submaxillary gland androgen regulated protein 3A	Homo sapiens	91-94
16278104-4	2006	Using S1 preparations cleaved with elastase, we could show that the residue of 567-578 loop that can be cross-linked to actin in the presence of MgADP.AlF4 is Lys-574.	Lysine	159-162	actin	Oryctolagus cuniculus	120-125
25866881-7	2015	Changing the lysines at positions 73, 78, and 85 to arginines suppressed the ubiquitination of A/Puerto Rico/8/1934 (H1N1)-derived PB1-F2.	Lysine	13-20	submaxillary gland androgen regulated protein 3A	Homo sapiens	131-134
25866881-8	2015	The mutation of the C-terminal lysine residue cluster positively affected the overall expression levels of avian A/Honk Kong/156/1997 (H5N1)- and mammalian A/Puerto Rico/8/1934 (H1N1)-derived PB1-F2.	Lysine	31-37	submaxillary gland androgen regulated protein 3A	Homo sapiens	192-195
25652097-8	2015	Moreover, we report that the interplay between SUZ12 and JMJD3 results in dynamic regulation of lysine 27 trimethylation of histone 3 (H3K27me3).	Lysine	96-102	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	57-62
12702756-2	2003	As a prototype, we developed a targeting device that is based on the formation of a covalent bond of defined stoichiometry between a 1,3-diketone derivative of an integrin alpha(v)beta(3) and alpha(v)beta(5) targeting Arg-Gly-Asp peptidomimetic and the reactive lysine of aldolase antibody 38C2.	Lysine	262-268	integrin subunit alpha V	Homo sapiens	163-187
12699393-3	2003	To realize the advantages of this approach, a lysine-hynic conjugate Fmoc-N-epsilon-(Hynic-Boc)-Lys was synthesized for incorporating the well-known technetium-99m-binding hydrazinonicotinamide ligand into peptides during SPPS.	Lysine	46-52	BOC cell adhesion associated, oncogene regulated	Homo sapiens	91-94
12699393-3	2003	To realize the advantages of this approach, a lysine-hynic conjugate Fmoc-N-epsilon-(Hynic-Boc)-Lys was synthesized for incorporating the well-known technetium-99m-binding hydrazinonicotinamide ligand into peptides during SPPS.	Lysine	96-99	BOC cell adhesion associated, oncogene regulated	Homo sapiens	91-94
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Lysine	68-74	integrin subunit beta 1	Homo sapiens	113-127
16452303-3	2006	In the first step, deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the epsilon-amino group of one specific lysine residue of the eIF5A precursor to form a deoxyhypusine intermediate.	Lysine	176-182	eukaryotic translation initiation factor 5A	Homo sapiens	198-203
25785610-3	2015	In these algorithms an occupation of the V3 positions 11 and 25, by one of the amino acids lysine (K) or arginine (R), is an indicator for CXCR4 usage.	Lysine	91-97	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
12667064-5	2003	This approach identified ADAM 28 residues Lys(437), Lys(442), Lys(455), Lys(459), Lys(460), Lys(469), and Glu(476) as being essential for alpha4beta1-dependent cell adhesion.	Lysine	42-45	ADAM metallopeptidase domain 28	Homo sapiens	25-32
16293626-0	2006	DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines.	Lysine	116-123	histone deacetylase 4	Homo sapiens	20-41
12547827-7	2003	Our data further suggest that potent, yet highly selective, PTP1B inhibitory agents can be acquired by targeting the area defined by residues Lys-41, Arg-47, and Asp-48, in addition to the previously identified second aryl phosphate-binding pocket.	Lysine	142-145	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	60-65
12641448-1	2003	The small ubiquitin-like modifier SUMO-1 is covalently attached to lysine residues on target proteins by a specific conjugation pathway involving the E1 enzyme SAE1/SAE2 and the E2 enzyme Ubc9.	Lysine	67-73	SUMO1 activating enzyme subunit 1	Homo sapiens	160-164
25727006-2	2015	We have discovered that CUL4A-RBX1-COPS8 E3 ligase activity is required for CENP-A ubiquitylation on lysine 124 (K124) and CENP-A centromere localization.	Lysine	101-107	ring-box 1	Homo sapiens	30-34
12471026-8	2003	Comparison of their sequences reveals two variants at Na(v)1.4 positions 729 and 732: Ser and Asn in Na(v)1.4 compared with Thr and Lys in Na(v)1.1, respectively.	Lysine	132-135	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	54-62
16293626-5	2006	The C-terminal lysines of p53, which are acetylated and methylated, are required for HDAC4 recruitment and transcriptional repression.	Lysine	15-22	histone deacetylase 4	Homo sapiens	85-90
16214042-7	2006	Furthermore, it was shown that USP31 has a higher activity towards lysine-63-linked as compared to lysine-48-linked polyubiquitin chains.	Lysine	67-73	ubiquitin specific peptidase 31	Homo sapiens	31-36
12509351-6	2003	The results demonstrate that mutations of Lys(56) and Val(185) within the amphipathic groove disrupt the ability of GF14-6 to interact with H(+)-ATPase and to stimulate its activity.	Lysine	42-45	14-3-3-like protein GF14-6	Zea mays	116-122
25590535-7	2015	In silico and in vitro studies show that POL3026 and its conjugates demonstrate similar interactions with different micelles that mimic cellular membrane and that the epsilon-NH2 of lysine(7) is critical to maintain high affinity to CXCR4.	Lysine	182-188	C-X-C motif chemokine receptor 4	Homo sapiens	233-238
16214042-7	2006	Furthermore, it was shown that USP31 has a higher activity towards lysine-63-linked as compared to lysine-48-linked polyubiquitin chains.	Lysine	99-105	ubiquitin specific peptidase 31	Homo sapiens	31-36
26020882-5	2015	Increasing the SID Trp to Lys ratio increased ADG (linear and quadratic effect, &lt; 0.05) and also improved G:F (linear and quadratic effect, &lt; 0.05).	Lysine	26-29	ADG	Sus scrofa	46-49
16426974-2	2006	Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage.	Lysine	43-49	H3 histone pseudogene 16	Homo sapiens	209-212
25604666-0	2015	Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport.	Lysine	26-32	solute carrier family 6 member 3	Homo sapiens	62-82
12604353-8	2003	Similar to human, mouse H2RSP mRNA (0.5kb) was detected abundantly in various tissues including the gastrointestinal tract, and has nuclear localization signal (NLS) in the lysine-rich region (exon 4), which was well-conserved between human and mouse genes.	Lysine	173-179	RIKEN cDNA 2200002D01 gene	Mus musculus	24-29
26718039-5	2006	The processes of adding and removing methyl groups on histone Lys residues are catalyzed by histone Lys methyltransferases (HKMTs) and histone-Lys-specific demethylase (LSD), respectively.	Lysine	62-65	deoxyribonuclease 1 like 3	Homo sapiens	135-167
12653715-5	2003	In the Russian family, we found a G to A transition at the first base of codon 402, resulting in a lysine substitution (GAG to AAG), designated E402K.	Lysine	99-105	N-methylpurine DNA glycosylase	Homo sapiens	127-130
12653715-6	2003	In the Colombian family, affected patients carried a missense mutation of codon 413, involving a transition from G to A causing a lysine substitution (GAG to AAG), designated E413K.	Lysine	130-136	N-methylpurine DNA glycosylase	Homo sapiens	158-161
25686248-5	2015	In mammalian cells, Huntingtin physically interacts with the autophagy cargo receptor p62 to facilitate its association with the integral autophagosome component LC3 and with Lys-63-linked ubiquitin-modified substrates.	Lysine	175-178	nucleoporin 62	Homo sapiens	86-89
25391294-6	2015	Using both biochemical and FRET-/FLIM-based approaches, we demonstrated that SUMO2 is robustly conjugated to p35 in cells and identified the two major SUMO acceptor lysines in p35, K246 and K290.	Lysine	165-172	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	176-179
26718039-5	2006	The processes of adding and removing methyl groups on histone Lys residues are catalyzed by histone Lys methyltransferases (HKMTs) and histone-Lys-specific demethylase (LSD), respectively.	Lysine	62-65	deoxyribonuclease 1 like 3	Homo sapiens	169-172
16357268-13	2006	Theoretically important findings are: 1) when heated, serum PG is capable of covalently binding to micellar casein or complexing with beta-LG in whey and then coadhering to micelles, and 2) PG that associated with micellar casein through lysine binding sites before heating is capable of developing heat-induced disulfide bonds with casein.	Lysine	238-244	plasminogen	Bos taurus	60-62
25581615-4	2015	A first subset (n=12) of GSCs exhibited a dramatic accumulation of the metabolite alpha-aminoadipate (alphaAAD), product of the oxidation of alpha-aminoadipic semialdehyde catalyzed by the ALDH7A1 aldehyde dehydrogenase (ALDH) family in lysine catabolism.	Lysine	237-243	aldehyde dehydrogenase 7 family member A1	Homo sapiens	189-196
25581615-4	2015	A first subset (n=12) of GSCs exhibited a dramatic accumulation of the metabolite alpha-aminoadipate (alphaAAD), product of the oxidation of alpha-aminoadipic semialdehyde catalyzed by the ALDH7A1 aldehyde dehydrogenase (ALDH) family in lysine catabolism.	Lysine	237-243	aldehyde dehydrogenase 7 family member A1	Homo sapiens	189-193
12590979-3	2003	The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).	Lysine	217-220	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-64
12590979-3	2003	The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).	Lysine	217-220	intercellular adhesion molecule 1	Homo sapiens	210-216
12631736-5	2003	Mutagenesis of lysines by alanine substitution defined a KKAILKKKEEK sequence within the central domain of Sgk between amino acids 131-141 that functions as a nuclear localization signal (NLS) required for the in vitro interaction with importin-alpha and for nuclear import of full-length Sgk in cultured cells.	Lysine	15-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	107-110
25605246-0	2015	NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect.	Lysine	25-31	calpain 3	Homo sapiens	0-4
16354696-5	2006	However, depletion of Paf1 reduces trimethylation of histone H3 at lysine 4 in the Hsp70 promoter region and significantly decreases the recruitment of chromatin-associated factors Spt6 and FACT, suggesting that Paf1 may manifest its effects on transcription through modulating chromatin structure.	Lysine	67-73	Spt6	Drosophila melanogaster	181-185
25582859-5	2015	Strikingly, H2O2 also promotes cxcl8 expression through modulation of histone 3 lysine 4 trimethylation, histone 3 lysine 9 acetylation, and histone 3 lysine 9 trimethylation levels at its promoter.	Lysine	80-86	chemokine (C-X-C motif) ligand 8a	Danio rerio	31-36
25582859-5	2015	Strikingly, H2O2 also promotes cxcl8 expression through modulation of histone 3 lysine 4 trimethylation, histone 3 lysine 9 acetylation, and histone 3 lysine 9 trimethylation levels at its promoter.	Lysine	115-121	chemokine (C-X-C motif) ligand 8a	Danio rerio	31-36
25582859-5	2015	Strikingly, H2O2 also promotes cxcl8 expression through modulation of histone 3 lysine 4 trimethylation, histone 3 lysine 9 acetylation, and histone 3 lysine 9 trimethylation levels at its promoter.	Lysine	115-121	chemokine (C-X-C motif) ligand 8a	Danio rerio	31-36
12631736-5	2003	Mutagenesis of lysines by alanine substitution defined a KKAILKKKEEK sequence within the central domain of Sgk between amino acids 131-141 that functions as a nuclear localization signal (NLS) required for the in vitro interaction with importin-alpha and for nuclear import of full-length Sgk in cultured cells.	Lysine	15-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	289-292
12631327-4	2003	The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity).	Lysine	183-189	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	37-44
12631327-7	2003	AtmBAC1 appeared to be more stereospecific than the yeast and mammalian ornithine carriers, exhibiting greater preference for the l-forms of arginine, lysine and ornithine.	Lysine	151-157	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-7
12482845-8	2003	We propose that the electrostatic interactions in the first TPR motif made by Lys(8) or Asn(12) define part of the minimum interactions required for successful mSTI1-Hsc70 interaction.	Lysine	78-81	heat shock protein family A (Hsp70) member 8	Homo sapiens	166-171
16475002-6	2006	The purified KAP had a K(m) of 333 microM with a V(max) of 0.7 nmol Lys ssNA/min/mg protein.	Lysine	68-71	kidney androgen regulated protein	Rattus norvegicus	13-16
12591902-10	2003	Mutation of the lysine residue within the transmembrane domain of CD158j abolished JNK activation, suggesting that an alternate adaptor molecule was being used.	Lysine	16-22	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2	Homo sapiens	66-72
25544292-6	2015	We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at the Stra6 RARE; 2) RA increases co-activator p300 (KAT3B) binding and histone H3 Lys-27 acetylation at both promoters; 3) RA decreases Suz12 levels and histone H3 Lys-27 trimethylation epigenetic marks at both promoters; and 4) these epigenetic changes are diminished in the absence of RARgamma.	Lysine	249-252	retinoic acid receptor, gamma	Mus musculus	49-57
16344468-1	2005	In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating cell nuclear antigen (PCNA) at Lys-164.	Lysine	157-160	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	31-35
12431996-4	2003	Using K48A and K63A Ub mutants, we found that BARD1 stimulated the formation of both Lys(48)- and Lys(63)-linked poly-Ub chains.	Lysine	85-88	BRCA1 associated RING domain 1	Homo sapiens	46-51
16337587-2	2005	In the November 23 issue of Molecular Cell, identified CHIP as a protein that interacts with the ubiquitin E2 complex Ubc13-Uev1A, which catalyzes the synthesis of Lys-63-linked polyubiquitin chains.	Lysine	164-167	ubiquitin conjugating enzyme E2 N	Homo sapiens	118-123
12431996-4	2003	Using K48A and K63A Ub mutants, we found that BARD1 stimulated the formation of both Lys(48)- and Lys(63)-linked poly-Ub chains.	Lysine	98-101	BRCA1 associated RING domain 1	Homo sapiens	46-51
12431996-5	2003	However, the enhancement of BRCA1 autoubiquitylation by BARD1 mostly resulted in poly-Ub chains linked through Lys(63), which could potentially activate biological pathways other than BRCA1 degradation.	Lysine	111-114	BRCA1 DNA repair associated	Homo sapiens	28-33
12431996-5	2003	However, the enhancement of BRCA1 autoubiquitylation by BARD1 mostly resulted in poly-Ub chains linked through Lys(63), which could potentially activate biological pathways other than BRCA1 degradation.	Lysine	111-114	BRCA1 associated RING domain 1	Homo sapiens	56-61
12564926-3	2003	It has been found that the full-length HMGB1 protein and its domain B to which the lysine-rich region (seven amino acid residues) of the A/B linker is attached at the N-terminus (the domain HMGB1b7) specifically recognize DNA interstrand cross-linked by cisplatin.	Lysine	83-89	high mobility group box 1	Rattus norvegicus	39-44
25520177-1	2015	Lysine (K)-specific demethylase 6B (KDM6B) is a histone H3K27 demethylase, which specifically catalyzes the demethylation of H3 lysine-27 tri/dimethylation (H3K27me3/2).	Lysine	0-6	lysine demethylase 6B	Homo sapiens	36-41
25520177-1	2015	Lysine (K)-specific demethylase 6B (KDM6B) is a histone H3K27 demethylase, which specifically catalyzes the demethylation of H3 lysine-27 tri/dimethylation (H3K27me3/2).	Lysine	128-134	lysine demethylase 6B	Homo sapiens	36-41
16337587-2	2005	In the November 23 issue of Molecular Cell, identified CHIP as a protein that interacts with the ubiquitin E2 complex Ubc13-Uev1A, which catalyzes the synthesis of Lys-63-linked polyubiquitin chains.	Lysine	164-167	ubiquitin conjugating enzyme E2 V1	Homo sapiens	124-129
25541374-7	2015	We also identified residues that were less critical or not required for recognition by the mammalian kinases (Ala 31, Met 44, Lys 79, and Tyr 81), even though they were essential for recognition of the yeast eIF2alpha by GCN2.	Lysine	126-129	eukaryotic translation initiation factor 2A	Homo sapiens	208-217
16247734-7	2005	NF-L protein, Hsc70, alpha-tubulin fragments, beta-actin, and brain-type creatine kinase were identified as putative lysine-methylated proteins in mouse brain.	Lysine	117-123	neurofilament, light polypeptide	Mus musculus	0-4
25498833-0	2015	Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla.	Lysine	27-33	dynein axonemal intermediate chain 3	Mus musculus	53-58
12527768-8	2003	Of particular interest, ECP/RNase 3"s cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine.	Lysine	141-147	ribonuclease A family member 3	Homo sapiens	24-27
16150736-6	2005	Moreover, the Lys-1016 mutation markedly reduced WRN helicase activity on fork, D-loop, and Holliday junction substrates in addition to reducing significantly the ability of WRN to stimulate FEN-1 incision activities.	Lysine	14-17	flap structure-specific endonuclease 1	Homo sapiens	191-196
12498914-2	2003	Previously we showed that one of our brain-penetrating neurotensin analogs, NT69L (N-met-L-Arg, L-Lys, L-Pro, L-neo-Trp, L-tert-Leu, L-Leu), blocks cocaine- and D-amphetamine-induced hyperactivity in rats.	Lysine	96-101	neurotensin	Rattus norvegicus	55-66
25492870-4	2015	Efficient degradation of lysine-free Asi2 requires E3-ligase Doa10 and E2 enzymes Ubc6 and Ubc7, components of the endoplasmic reticulum-associated degradation pathway.	Lysine	25-31	E3 ubiquitin-protein ligase SSM4	Saccharomyces cerevisiae S288C	61-66
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	31-37	metalloaminopeptidase APE1	Saccharomyces cerevisiae S288C	130-135
25785047-1	2015	OBJECTIVES: In order to investigate the encapsulation of interleukin 1 receptor antagonist (IL-RA) gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of interleukin 1 receptor antagonist (IL-RA) to treat Rheumatoid arthritis (RA).	Lysine	155-168	interleukin 1 receptor antagonist	Rattus norvegicus	92-97
12459913-9	2003	Those PBGS with the aspartate-rich metal switch sequence contain Lys in the analogous position.	Lysine	65-68	aminolevulinate dehydratase	Homo sapiens	6-10
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	153-156	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-128
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	153-156	O-6-methylguanine-DNA methyltransferase	Homo sapiens	135-139
12393892-0	2002	The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains.	Lysine	45-51	Saccharopine dehydrogenase	Arabidopsis thaliana	76-102
12393892-1	2002	Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in animals and plants.	Lysine	127-133	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	0-57
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	48-51	metalloaminopeptidase APE1	Saccharomyces cerevisiae S288C	130-135
12393892-1	2002	Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in animals and plants.	Lysine	127-133	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	59-66
12393892-8	2002	The relevance of our results to the in vivo function of LKR/SDH in lysine catabolism in plants is discussed.	Lysine	67-73	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	56-63
16186126-7	2005	Atg19p is ubiquitinated on two lysine residues, Lys(213) and Lys(216), which, when mutated, reduce the interaction of Atg19p with Ape1p.	Lysine	61-64	metalloaminopeptidase APE1	Saccharomyces cerevisiae S288C	130-135
12393892-9	2002	In addition, because the linker region between LKR and SDH exists only in plants but not in animal LKR/SDH enzymes, our results suggest that the regulatory properties of LKR/SDH and, hence, the regulation of lysine catabolism are different between plants and animals.	Lysine	208-214	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	47-50
12393892-9	2002	In addition, because the linker region between LKR and SDH exists only in plants but not in animal LKR/SDH enzymes, our results suggest that the regulatory properties of LKR/SDH and, hence, the regulation of lysine catabolism are different between plants and animals.	Lysine	208-214	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	55-58
16307923-9	2005	In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression.	Lysine	127-134	PCNA clamp associated factor	Homo sapiens	50-54
12393892-9	2002	In addition, because the linker region between LKR and SDH exists only in plants but not in animal LKR/SDH enzymes, our results suggest that the regulatory properties of LKR/SDH and, hence, the regulation of lysine catabolism are different between plants and animals.	Lysine	208-214	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	170-177
12393902-7	2002	This study also suggests that ubiquitination of Mdm2 and MdmX may not serve as a signal for degradation, as we show that each are capable of synthesizing non-lysine 48 polyubiquitin chains and, in fact, utilize multiple lysine linkages.	Lysine	158-164	MDM2 proto-oncogene	Homo sapiens	48-52
12393906-5	2002	When several lysine residues of Mdm2 were sequentially mutated to arginine, the K182R mutant was not sumoylated in intact cells; however, in the in vitro system this mutant was sumoylated by PIAS1, PIASxbeta, and RanBP2 as efficiently as the wild-type Mdm2 protein.	Lysine	13-19	MDM2 proto-oncogene	Homo sapiens	32-36
25529796-4	2015	Genetic deletion of Sirt1 increased mitochondrial superoxide dismutase 2 (Sod2) acetylation of lysine residue 68, thereby enhancing reactive oxygen species (ROS) production and reducing SOD2 activity.	Lysine	95-101	sirtuin 1	Homo sapiens	20-25
25380462-3	2015	Recently, a dinucleotide substitution located in the exon 8 of the gene coding for acyl CoA: diacylglycerol acyltransferase 1 (DGAT1), that alters the amino acid sequence from a lysine to an alanine (p.Lys232Ala) in the mature protein, was shown to have a strong effect on milk fat content in some cattle breeds.	Lysine	178-184	diacylglycerol O-acyltransferase 1	Bos taurus	127-132
16127177-3	2005	Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys(9) of histone H3 (K9/H3).	Lysine	110-113	chromobox 5	Homo sapiens	0-26
25560918-8	2015	Phosphorylation near a lysine residue significantly reduced the affinity of TIP60 for the modified histone peptides.	Lysine	23-29	lysine acetyltransferase 5	Homo sapiens	76-81
12475234-3	2002	MALDI mass spectrometry analysis designated lysines 154, 162, 170, 533, 554, 593, 894, 930, and 940 of ValRS as the target residues for the attachment of valine.	Lysine	44-51	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	103-108
12475234-6	2002	Alignment of the available ValRS amino acid sequences showed that lysines 277 and 554 are strictly conserved (with the exception concerning replacement of Lys-277 with a methionine or a tyrosine in archaebacteria), suggesting that these residues might be functionally significant.	Lysine	66-73	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	27-32
12475234-7	2002	Indeed, lysine 554 of ValRS is the first lysine of the Lys-Met-Ser-Lys-Ser signature of the catalytic site of class I aminoacyl-tRNA synthetases.	Lysine	8-14	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	22-27
12475234-7	2002	Indeed, lysine 554 of ValRS is the first lysine of the Lys-Met-Ser-Lys-Ser signature of the catalytic site of class I aminoacyl-tRNA synthetases.	Lysine	41-47	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	22-27
12475234-7	2002	Indeed, lysine 554 of ValRS is the first lysine of the Lys-Met-Ser-Lys-Ser signature of the catalytic site of class I aminoacyl-tRNA synthetases.	Lysine	55-58	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	22-27
16127177-3	2005	Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys(9) of histone H3 (K9/H3).	Lysine	110-113	chromobox 5	Homo sapiens	28-31
12475234-7	2002	Indeed, lysine 554 of ValRS is the first lysine of the Lys-Met-Ser-Lys-Ser signature of the catalytic site of class I aminoacyl-tRNA synthetases.	Lysine	67-70	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	22-27
12475234-8	2002	Lys-277 which is labeled by L-threonine or L-methionine, and not by L-valine, is located at or near the editing site, in the three-dimensional structure of ValRS.	Lysine	0-3	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	156-161
25613642-3	2015	Interestingly, HDAC9, a histone deacetylase responsible for deacetylating lysine 18 of histone 3 (H3K18), was identified as the target of miR-376a.	Lysine	74-80	histone deacetylase 9	Homo sapiens	15-20
12452668-4	2002	By the sequence analysis of the peptide fragments containing two N termini, which indicates the presence of cross-linked peptide, the lysine residues targeted by TGases were identified as follows: for GTGase, Lys16, Lys93, and Lys122; for MTGase, Lys5.	Lysine	134-140	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	247-251
16129677-1	2005	A dissociation constant of K(D) = 62 mum was obtained for the interaction of peptidoglycan recognition protein (PGRP)-Ialpha with the lysine-containing muramyl pentapeptide (compound 6).	Lysine	134-140	peptidoglycan recognition protein 3	Homo sapiens	112-124
12524336-5	2002	The suppressing mutation in SPN1 substitutes an asparagine for an invariant lysine at position 192 (spn1(K192N)).	Lysine	76-82	Spn1p	Saccharomyces cerevisiae S288C	28-32
12524336-5	2002	The suppressing mutation in SPN1 substitutes an asparagine for an invariant lysine at position 192 (spn1(K192N)).	Lysine	76-82	Spn1p	Saccharomyces cerevisiae S288C	100-104
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Lysine	147-150	apelin	Rattus norvegicus	112-118
16129677-5	2005	Surprisingly, PGRP-S derived significantly higher affinities for the DAP-containing fragments to similar lysine-containing derivatives, and the following dissociation constants were measured: muramylpentapeptide-DAP, K(D) = 104 nm; muramyltetrapeptide-DAP, 92.4 nm; and muramyltripeptide-DAP, 326 nm.	Lysine	105-111	peptidoglycan recognition protein 1	Homo sapiens	14-20
16129677-6	2005	The binding profiles were rationalized by using a recently reported x-ray crystal structure of PGRP-Ialpha with the lysine-containing muramyltripeptide (4).	Lysine	116-122	peptidoglycan recognition protein 3	Homo sapiens	95-106
16222338-3	2005	We find that PU.1 inhibits the erythroid program by binding to GATA-1 on its target genes and organizing a complex of proteins that creates a repressive chromatin structure containing lysine-9 methylated H3 histones and heterochromatin protein 1.	Lysine	184-190	Spi-1 proto-oncogene	Homo sapiens	13-17
26478496-2	2015	The genetic encoding of the noncanonical amino acid spin-labeled lysine 1 (SLK-1) eliminates the need for any chemical labeling steps in SDSL-EPR studies and enables the investigation of native, endogenous proteins with minimal structural perturbation, and without the need to create unique reactive sites for chemical labeling.	Lysine	65-71	spindlin 1	Homo sapiens	52-56
12426395-4	2002	The HDAC1 complex binds MDM2 in a p53-independent manner and deacetylates p53 at all known acetylated lysines in vivo.	Lysine	102-109	MDM2 proto-oncogene	Homo sapiens	24-28
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	MDM2 proto-oncogene	Homo sapiens	186-190
12426395-8	2002	As the acetylated p53 lysine residues overlap with those that are ubiquitylated, our results suggest that one major function of p53 acetylation is to promote p53 stability by preventing MDM2-dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.	Lysine	22-28	MDM2 proto-oncogene	Homo sapiens	247-251
16269333-2	2005	Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain.	Lysine	99-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	63-66
12407083-11	2002	Replacement of two outer vestibule lysines in Kv2.1 by smaller neutral amino acids made current magnitude dramatically more sensitive to the reduction in K+ driving force (current magnitude changed by as much as 40%).	Lysine	35-42	potassium voltage-gated channel subfamily B member 1	Homo sapiens	46-51
26179046-3	2015	Both Gli1 and Gli2 are acetylated at a conserved lysine, and this modification causes the inhibition of their transcriptional activity.	Lysine	49-55	GLI family zinc finger 1	Homo sapiens	5-9
16185069-1	2005	In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate, a reaction catalyzed by dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52).	Lysine	44-54	dihydrodipicolinate synthase	Escherichia coli	171-199
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	223-229	SET domain group 26	Arabidopsis thaliana	67-72
25409787-7	2015	Our analyses of the chromatin of flowering genes revealed that the SDG26 protein binds at the key flowering integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20), and is required for histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 36 trimethylation (H3K36me3) at this locus.	Lysine	272-278	SET domain group 26	Arabidopsis thaliana	67-72
12407083-12	2002	When combined, these outer vestibule properties (fixed conformation during activation and the presence of lysines) all but prevent variation in Kv2.1 current magnitude when [K+] changes during activation.	Lysine	106-113	potassium voltage-gated channel subfamily B member 1	Homo sapiens	144-149
12368900-1	2002	Yeast ESA1 is a member of the MYST subfamily of histone acetyltransferases (HATs), which use acetyl-coenzyme A (CoA) to acetylate specific Lys residues within histones to regulate gene expression.	Lysine	139-142	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	6-10
16185069-1	2005	In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate, a reaction catalyzed by dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52).	Lysine	44-54	dihydrodipicolinate synthase	Escherichia coli	201-206
12368900-1	2002	Yeast ESA1 is a member of the MYST subfamily of histone acetyltransferases (HATs), which use acetyl-coenzyme A (CoA) to acetylate specific Lys residues within histones to regulate gene expression.	Lysine	139-142	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	30-34
16185069-2	2005	It has been proposed that Arg138, a residue situated at the entrance to the active site of DHDPS, is responsible for binding the carboxyl of (S)-ASA and may additionally be involved in the mechanism of (S)-lysine inhibition.	Lysine	202-212	dihydrodipicolinate synthase	Escherichia coli	91-96
25161153-4	2015	The ligand binding extracellular domain of VEGFR-2 is composed of seven immunoglobulin-like domains highly decorated with N-glycosylation, while its cytoplasmic domain is subject to multiple PTMs including Tyr, Ser/Thr phosphorylation, Arg and Lys methylation, acetylation and ubiquitination.	Lysine	244-247	kinase insert domain receptor	Homo sapiens	43-50
16152638-6	2005	Of those variants, the G7444A mutation is of special interest as the mutation at this position results in a read-through of the stop condon AGA of the COI message, thereby adding three amino acids (Lys-Gln-Lys) to the C-terminal of the polypeptide.	Lysine	198-201	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	151-154
25527207-9	2014	ChIP analysis revealed that PRC2-mediated trimethylation of Lys 27 on histone H3 (H3K27me3) was increased in the KRT13 promoter in the HSC3 and SAS cells.	Lysine	60-63	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	135-139
25055869-4	2014	Here, we show that the level of trimethylation of histone H3 on lysine 27, a hallmark of the activity of EZH2, a component of repressive Polycomb Group (PcG) complexes like PRC2, is increased on reactivation of the silenced allele by either the DNA demethylating agent 5-azadeoxycytidine or the SIRT1 inhibitor splitomicin.	Lysine	64-70	sirtuin 1	Homo sapiens	295-300
12391296-5	2002	Here we report on the crystal structure of the GCN5 HAT bound to a peptide-CoA conjugate containing CoA covalently attached through an isopropionyl linker to Lys-14 of a 20-aa N-terminal fragment of histone H3.	Lysine	158-161	lysine acetyltransferase 2A	Homo sapiens	47-51
12397363-5	2002	5) is a multi-catalytic histone methyl-transferase (HMTase) that methylates lysine residues 4 and 9 in H3 and 20 in H4.	Lysine	76-82	G9a	Drosophila melanogaster	24-50
12397363-5	2002	5) is a multi-catalytic histone methyl-transferase (HMTase) that methylates lysine residues 4 and 9 in H3 and 20 in H4.	Lysine	76-82	G9a	Drosophila melanogaster	52-58
16152638-6	2005	Of those variants, the G7444A mutation is of special interest as the mutation at this position results in a read-through of the stop condon AGA of the COI message, thereby adding three amino acids (Lys-Gln-Lys) to the C-terminal of the polypeptide.	Lysine	206-209	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	151-154
12231507-1	2002	In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9).	Lysine	117-123	Heterochromatin Protein 1c	Drosophila melanogaster	68-71
15956276-5	2005	Here we show that human PGRP-S binds to and inhibits the growth of Staphylococcus aureus (containing lysine-type PGN) and Escherichia coli (containing mesodiaminopimelic acid-type PGN).	Lysine	101-107	peptidoglycan recognition protein 1	Homo sapiens	24-30
12082087-10	2002	Deletion of Lys(50) or Met(51) caused a dramatic loss in stability of the U1A.U1hpII complex.	Lysine	12-15	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	74-77
12084729-5	2002	We found that Schizosaccharomyces pombe Csk1, Candida albicans Cak1, and Arabidopsis thaliana Cak1At, like Cak1p, all displayed a preference for cyclin-free cdk substrates, were insensitive to the protein kinase inhibitor 5"-fluorosulfonylbenzoyladenosine (FSBA), and were insensitive to mutation of a highly conserved lysine residue found in the nucleotide binding pocket of all protein kinases.	Lysine	319-325	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	63-67
12084729-5	2002	We found that Schizosaccharomyces pombe Csk1, Candida albicans Cak1, and Arabidopsis thaliana Cak1At, like Cak1p, all displayed a preference for cyclin-free cdk substrates, were insensitive to the protein kinase inhibitor 5"-fluorosulfonylbenzoyladenosine (FSBA), and were insensitive to mutation of a highly conserved lysine residue found in the nucleotide binding pocket of all protein kinases.	Lysine	319-325	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	107-112
25301942-5	2014	Mutagenesis of these lysines to arginines completely abolishes the autoacetylation of TIP60.	Lysine	21-28	lysine acetyltransferase 5	Homo sapiens	86-91
16177304-6	2005	The basic residues in granulysin are arginine, while those in NK-lysin and chicken NK-lysin are a mixture of arginine and lysine.	Lysine	122-128	granulysin	Gallus gallus	62-70
25348736-0	2014	Lysine residues 639 and 673 of mouse Ncoa3 are ubiquitination sites for the regulation of its stability.	Lysine	0-6	nuclear receptor coactivator 3	Mus musculus	37-42
25348736-4	2014	Replacing two lysine residues, K639 and K673, within this region by arginine, increases the stability of the luciferase fusion protein as well as Ncoa3 protein.	Lysine	14-20	nuclear receptor coactivator 3	Mus musculus	146-151
25348736-5	2014	When these two lysine residues are mutated to arginine, the overall ubiquitination level of Ncoa3 decreases, indicating that lysine 639 and 673 are its ubiquitination sites.	Lysine	15-21	nuclear receptor coactivator 3	Mus musculus	92-97
25348736-5	2014	When these two lysine residues are mutated to arginine, the overall ubiquitination level of Ncoa3 decreases, indicating that lysine 639 and 673 are its ubiquitination sites.	Lysine	125-131	nuclear receptor coactivator 3	Mus musculus	92-97
25348736-6	2014	Taken together, we identified two ubiquitination sites at lysine 639 and 673 of Ncoa3.	Lysine	58-64	nuclear receptor coactivator 3	Mus musculus	80-85
12169606-3	2002	The purified rVisA showed clear L-lysine 2-aminotransferase activity with an optimum pH of around 8.0 and an optimum temperature at 35 degrees C, with 2-oxohexanoate as the best amino acceptor, indicating that VisA converts L-lysine into Delta(1)-piperidine 2-carboxylic acid.	Lysine	32-40	mitochondrial antiviral signaling protein	Rattus norvegicus	13-18
12169606-3	2002	The purified rVisA showed clear L-lysine 2-aminotransferase activity with an optimum pH of around 8.0 and an optimum temperature at 35 degrees C, with 2-oxohexanoate as the best amino acceptor, indicating that VisA converts L-lysine into Delta(1)-piperidine 2-carboxylic acid.	Lysine	32-40	mitochondrial antiviral signaling protein	Rattus norvegicus	14-18
25348736-7	2014	Ubiquitination of these two lysine residues leads to proteasomal degradation of Ncoa3.	Lysine	28-34	nuclear receptor coactivator 3	Mus musculus	80-85
16177304-6	2005	The basic residues in granulysin are arginine, while those in NK-lysin and chicken NK-lysin are a mixture of arginine and lysine.	Lysine	122-128	granulysin	Gallus gallus	83-91
16127432-2	2005	Neddylation, the process that conjugates the ubiquitin-like polypeptide Nedd8 to the conserved lysines of cullins, is essential for in vivo cullin-organized E3 activities.	Lysine	95-102	NEDD8 ubiquitin like modifier	Canis lupus familiaris	72-77
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	43-46	Saccharopine dehydrogenase	Arabidopsis thaliana	143-146
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	43-46	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	210-217
16006651-4	2005	Our mass spectrometric data showed that of 24 lysines and 18 arginines readily susceptible to small chemical reagent modification in native RPA, the three residues Lys-343, Arg-335, and Arg-382, located in DNA binding domain B (DBD-B) of RPA70, were significantly shielded in the hyperphosphorylated protein.	Lysine	46-53	replication protein A1	Homo sapiens	238-243
12226495-3	2002	In the present report, we have identified two cDNAs derived from cotton (Gossypium hirsutum) boll abscission zone that encode a novel enzymatic form of Lys catabolism, i.e. a catabolic monofunctional LKR.	Lysine	152-155	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	200-203
12226495-8	2002	The K(m) of the monofunctional LKR to Lys was nearly 10-fold lower than its counterpart that is linked to SDH.	Lysine	38-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	31-34
12226495-8	2002	The K(m) of the monofunctional LKR to Lys was nearly 10-fold lower than its counterpart that is linked to SDH.	Lysine	38-41	Saccharopine dehydrogenase	Arabidopsis thaliana	106-109
12226495-9	2002	Taken together, our results suggest that the LKR/SDH locus of plants is a super-composite locus that can encode three related but distinct enzymes of Lys catabolism.	Lysine	150-153	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	45-52
12077321-0	2002	Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content.	Lysine	17-23	diacylglycerol O-acyltransferase 1	Bos taurus	116-121
25220405-2	2014	In the heart, enhancement of lysine acetylation or SUMOylation using histone deacetylase (HDAC) inhibitors or SUMO-1 gene transfer, respectively, has been shown to be cardioprotective.	Lysine	29-35	histone deacetylase 9	Homo sapiens	69-88
25220405-2	2014	In the heart, enhancement of lysine acetylation or SUMOylation using histone deacetylase (HDAC) inhibitors or SUMO-1 gene transfer, respectively, has been shown to be cardioprotective.	Lysine	29-35	histone deacetylase 9	Homo sapiens	90-94
25220405-9	2014	These findings reveal a novel role for reversible lysine acetylation in the control of SUMOylation in the heart, and suggest that cardioprotective actions of HDAC inhibitors are in part due to stimulation of protein SUMO-1-ylation in myocytes and fibroblasts.	Lysine	50-56	histone deacetylase 9	Homo sapiens	158-162
16006651-4	2005	Our mass spectrometric data showed that of 24 lysines and 18 arginines readily susceptible to small chemical reagent modification in native RPA, the three residues Lys-343, Arg-335, and Arg-382, located in DNA binding domain B (DBD-B) of RPA70, were significantly shielded in the hyperphosphorylated protein.	Lysine	164-167	replication protein A1	Homo sapiens	238-243
16079794-0	2005	An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.	Lysine	54-60	REST corepressor 1	Homo sapiens	22-28
24986870-0	2014	Nuclear import of human histone lysine-specific demethylase LSD1.	Lysine	32-38	lysine demethylase 1A	Homo sapiens	60-64
25301943-1	2014	Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimulates interaction between nucleosomes and histone deacetylase complexes to block cryptic transcription in budding yeast.	Lysine	44-51	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	73-77
25301943-1	2014	Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimulates interaction between nucleosomes and histone deacetylase complexes to block cryptic transcription in budding yeast.	Lysine	44-51	histone deacetylase	Saccharomyces cerevisiae S288C	140-159
12063313-6	2002	After local blockade of PKC-beta II with LY-333531, the [NO] increased approximately 90 nm in obese rats but did not change in lean rats.	Lysine	41-43	protein kinase C, beta	Rattus norvegicus	24-35
16129825-6	2005	In addition to serving as a basis for the development of hMAO A specific inhibitors, these data support the proposal that hMAO A involves a change from the dimeric to the monomeric form through a Glu-151 --&gt; Lys mutation that is specific of hMAO A [Andres, A. M., Soldevila, M., Navarro, A., Kidd, K. K., Oliva, B.	Lysine	211-214	monoamine oxidase A	Homo sapiens	122-128
12069423-11	2002	Low-energy ESI-MS/MS confirmed the position of HylP within the sequence of I. Phosphorylation of Hyl led to complete resistance of I to lysine-specific endopeptidases.	Lysine	136-142	megakaryocyte-associated tyrosine kinase	Homo sapiens	47-50
25365214-0	2014	TPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response.	Lysine	42-48	TPX2 microtubule nucleation factor	Homo sapiens	0-4
16129825-6	2005	In addition to serving as a basis for the development of hMAO A specific inhibitors, these data support the proposal that hMAO A involves a change from the dimeric to the monomeric form through a Glu-151 --&gt; Lys mutation that is specific of hMAO A [Andres, A. M., Soldevila, M., Navarro, A., Kidd, K. K., Oliva, B.	Lysine	211-214	monoamine oxidase A	Homo sapiens	122-128
16135789-4	2005	Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha).	Lysine	22-28	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	91-95
25104733-2	2014	A recent study shows that protein lysine methylation controls the phosphorylation status of a key component of the RAS-MAPK pathway to enable oncogenic KRAS in cancer progression.	Lysine	34-40	KRAS proto-oncogene, GTPase	Homo sapiens	152-156
11923307-5	2002	By exchanging Lys(34), we found that AtHAL3a is not only able to decarboxylate 4"-phosphopantothenoylcysteine but also pantothenoylcysteine to pantothenoylcysteamine.	Lysine	14-17	HAL3-like protein A	Arabidopsis thaliana	37-43
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Lysine	251-257	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-138
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Lysine	251-257	inhibitor of kappaB kinase beta	Mus musculus	139-143
12086618-0	2002	PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.	Lysine	65-71	histone H4	Drosophila melanogaster	78-88
16135789-5	2005	Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310.	Lysine	251-257	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	165-169
25295537-4	2014	PELI1 directly interacted with the oncoprotein B cell chronic lymphocytic leukemia (BCL6) and induced lysine 63-mediated BCL6 polyubiquitination.	Lysine	102-108	pellino E3 ubiquitin protein ligase 1	Homo sapiens	0-5
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Lysine	141-147	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	32-36
25295537-4	2014	PELI1 directly interacted with the oncoprotein B cell chronic lymphocytic leukemia (BCL6) and induced lysine 63-mediated BCL6 polyubiquitination.	Lysine	102-108	BCL6 transcription repressor	Homo sapiens	121-125
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Lysine	141-147	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	95-99
11967294-10	2002	However, trans complementation was not observed when the C-terminal lysine of NS1-2Aalpha was replaced with serine.	Lysine	68-74	influenza virus NS1A binding protein	Homo sapiens	78-81
16135789-7	2005	Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene.	Lysine	135-141	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	18-22
25729870-5	2014	MATERIAL AND METHODS: Peptide RP13 was prepared modifying the original amino acids sequence of peptide RP11, reversing the position of the amino acids lysine and tyrosine in order to modify the conformation of the original peptide.	Lysine	151-157	pre-mRNA processing factor 8	Homo sapiens	30-34
16135789-7	2005	Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene.	Lysine	135-141	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	67-71
11939781-4	2002	The Fos coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide corresponding to the coiled-coil domain of v-Fos).	Lysine	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
11939781-4	2002	The Fos coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide corresponding to the coiled-coil domain of v-Fos).	Lysine	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
16135789-7	2005	Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene.	Lysine	135-141	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	67-71
11939781-5	2002	Lys 16 and Lys 30 of Fos-p1 were replaced individually and together with the unnatural amino acid norleucine (2-aminohexanoic acid), which corresponds to a deletion of the Lys epsilon-amino group.	Lysine	11-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-24
11939781-5	2002	Lys 16 and Lys 30 of Fos-p1 were replaced individually and together with the unnatural amino acid norleucine (2-aminohexanoic acid), which corresponds to a deletion of the Lys epsilon-amino group.	Lysine	11-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-24
16135789-8	2005	These findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536.	Lysine	56-62	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	48-52
11939781-10	2002	The results show that (i) the effects of buried position a Lys residues on coiled-coil oligomerization are context dependent and (ii) electrostatic destabilization of the Fos homodimer can be mitigated by an oligomerization switch moderated by a single buried Lys residue.	Lysine	59-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-174
11939781-10	2002	The results show that (i) the effects of buried position a Lys residues on coiled-coil oligomerization are context dependent and (ii) electrostatic destabilization of the Fos homodimer can be mitigated by an oligomerization switch moderated by a single buried Lys residue.	Lysine	260-263	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-174
16011830-1	2005	One variant of the syndrome is linked to missense mutations that lead to a single amino-acid change (N588K; asparagine to lysine) in the S5-Pore linker region of the cardiac HERG K(+) channel.	Lysine	122-128	potassium voltage-gated channel subfamily H member 2	Homo sapiens	174-178
11971195-0	2002	Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells.	Lysine	9-15	MDM2 proto-oncogene	Homo sapiens	96-100
11971195-0	2002	Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells.	Lysine	9-15	MDM2 proto-oncogene	Homo sapiens	168-172
24933258-4	2014	In our approach, we genetically encode a photocaged lysine into the nuclear localization signal (NLS) of the transcription factor SATB1.	Lysine	52-58	SATB homeobox 1	Homo sapiens	130-135
25264103-2	2014	In this study, we found that EED, a component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (H3K27), was involved in epithelial-mesenchymal transition (EMT) of cancer cells induced by Transforming Growth Factor-beta (TGF-beta).	Lysine	116-122	embryonic ectoderm development	Homo sapiens	29-32
16109848-3	2005	Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine residue (Lys259) in vivo.	Lysine	130-136	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	19-24
25071150-2	2014	We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-derived tumors, such as seminomas, yolk sac tumors, and embryonal carcinomas.	Lysine	72-78	lysine demethylase 3A	Homo sapiens	100-106
24905915-3	2014	We aimed at investigating the role, of the positive charged lysine residues at the KTKEGV repeat motif, in mediating alpha-Syn associations with membrane phospholipids and in alpha-Syn oligomerization and aggregation.	Lysine	60-66	synemin	Homo sapiens	123-126
11850414-3	2002	Both modifications lead to the binding of specific proteins; bromodomain proteins, such as GCN5, bind acetyl lysines and the chromodomain protein, HP1, binds methyl lysine 9 of histone H3.	Lysine	109-115	lysine acetyltransferase 2A	Homo sapiens	91-95
11898023-7	2002	These data suggest that CpNpG DNA methylation is controlled by histone H3 Lys 9 methylation, through interaction of CMT3 with methylated chromatin.	Lysine	74-77	chromomethylase 3	Arabidopsis thaliana	116-120
16029420-5	2005	Interestingly, MITF with double lysine 182/316 to arginine mutations, although displaying normal DNA binding, stability and nuclear localization, shows a substantial increase in the transcriptional stimulation of promoters containing multiple but not single MITF binding sites.	Lysine	32-38	melanocyte inducing transcription factor	Homo sapiens	15-19
11781309-8	2002	Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.	Lysine	31-37	serine C-palmitoyltransferase LCB2	Saccharomyces cerevisiae S288C	142-147
25274119-4	2014	Site-directed mutagenesis confirmed that the single cysteine (C(173)) of Gal-3 or lysine (K(166)) of LAMR1 are critical for heterodimerization.	Lysine	82-88	ribosomal protein SA	Mus musculus	101-106
25034019-6	2014	Mutations in the stem cell niche-expressed ASH1-RELATED3 (ASHR3) gene, encoding a SET-domain protein conferring histone H3 lysine-36 methylation, disrupted this pattern of coordinated DNA replication and cell division and increased the cell division rate in the quiescent center.	Lysine	123-129	SET domain group 4	Arabidopsis thaliana	43-56
16029420-6	2005	MITF containing the double lysine-to-arginine substitution also shows enhanced cooperation with Sox10 on the Dct promoter.	Lysine	27-33	melanocyte inducing transcription factor	Homo sapiens	0-4
25034019-6	2014	Mutations in the stem cell niche-expressed ASH1-RELATED3 (ASHR3) gene, encoding a SET-domain protein conferring histone H3 lysine-36 methylation, disrupted this pattern of coordinated DNA replication and cell division and increased the cell division rate in the quiescent center.	Lysine	123-129	SET domain group 4	Arabidopsis thaliana	58-63
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	177-184	activin A receptor type 1	Homo sapiens	133-156
16029420-6	2005	MITF containing the double lysine-to-arginine substitution also shows enhanced cooperation with Sox10 on the Dct promoter.	Lysine	27-33	SRY-box transcription factor 10	Homo sapiens	96-101
15997205-10	2005	The recognition of lysosomal proteins by GlcNAc-phosphotransferase is mediated by protein structure, and a specific three-dimensional arrangement of lysine residues exposed on the surface of several enzymes has been shown to be critical for mannose phosphorylation.	Lysine	149-155	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Homo sapiens	41-66
11675391-2	2002	Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the SCF-ROC1 E3 ubiquitin ligase, selectively stimulates Cdc34-catalyzed lysine 48-linked multiubiquitin chain assembly.	Lysine	148-154	ring-box 1	Homo sapiens	48-52
11675391-2	2002	Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the SCF-ROC1 E3 ubiquitin ligase, selectively stimulates Cdc34-catalyzed lysine 48-linked multiubiquitin chain assembly.	Lysine	148-154	ring-box 1	Homo sapiens	83-87
11675391-2	2002	Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the SCF-ROC1 E3 ubiquitin ligase, selectively stimulates Cdc34-catalyzed lysine 48-linked multiubiquitin chain assembly.	Lysine	148-154	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	132-137
24913280-1	2014	Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood.	Lysine	121-127	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	0-9
25118570-13	2014	In vitro ubiquitination assays indicate that HOIL-1L ubiquitinates PKCzeta at Lys-48, targeting it for proteasomal degradation.	Lysine	78-81	RanBP-type and C3HC4-type zinc finger containing 1	Mus musculus	45-52
11740489-3	2002	HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 at Ser 46, thus facilitating the CBP-mediated acetylation of p53 at Lys 382, and promoting p53-dependent gene expression.	Lysine	152-155	homeodomain interacting protein kinase 2	Homo sapiens	0-5
15964796-2	2005	Six lysine residues at the p53 C terminus can be posttranslationally modified by various mechanisms, including acetylation, ubiquitination, neddylation, methylation, and sumoylation.	Lysine	4-10	transformation related protein 53, pseudogene	Mus musculus	27-30
11577116-2	2001	Similar to the ubiquitin conjugation system, SUMO/Smt3 is transferred to substrate lysine residues through the thioester cascade of E1 (activating enzyme) and E2 (conjugating enzyme).	Lysine	83-89	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	50-54
25118570-13	2014	In vitro ubiquitination assays indicate that HOIL-1L ubiquitinates PKCzeta at Lys-48, targeting it for proteasomal degradation.	Lysine	78-81	protein kinase C zeta	Homo sapiens	67-74
15964796-3	2005	Previous cell line transfection studies show that ubiquitination of these lysine residues is required for ubiquitin-dependent degradation of p53.	Lysine	74-80	transformation related protein 53, pseudogene	Mus musculus	141-144
15964796-5	2005	To investigate the physiological functional outcome of these C-terminal modifications in regulating p53 stability and activity, we introduced missense mutations (lysine to arginine) at the six lysine residues (K6R) into the endogenous p53 gene in mouse embryonic stem (ES) cells.	Lysine	162-168	transformation related protein 53, pseudogene	Mus musculus	235-238
15964796-5	2005	To investigate the physiological functional outcome of these C-terminal modifications in regulating p53 stability and activity, we introduced missense mutations (lysine to arginine) at the six lysine residues (K6R) into the endogenous p53 gene in mouse embryonic stem (ES) cells.	Lysine	193-199	transformation related protein 53, pseudogene	Mus musculus	235-238
11732997-0	2001	Identification of a critical lysine residue at the active site in glyceraldehyde-3-phosphate dehydrogenase of Ehrlich ascites carcinoma cell.	Lysine	29-35	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	66-106
25229978-5	2014	Acetylation of lysine 154 was identified by mass spectrometry (MS) while deacetylation of lysine 155 by SIRT1 was confirmed by in vitro deacetylation assay.	Lysine	90-96	sirtuin 1	Homo sapiens	104-109
11732997-2	2001	The involvement of the lysine residue present at the active site of Ehrlich ascites carcinoma (EAC) cell glyceraldehyde-3-phosphate dehydrogenase (Gra3PDH) was investigated by using the lysine specific reagents trinitrobenzenesulfonic acid (TNBS) and pyridoxal phosphate (PP).	Lysine	23-29	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	105-145
15985640-5	2005	now demonstrate that the activity of an integral cytoplasmic membrane channel-forming protein, K2P1, is completely abrogated by sumoylation at a single lysine residue on the cytoplasmic tail.	Lysine	152-158	potassium two pore domain channel subfamily K member 1	Homo sapiens	95-99
11732997-2	2001	The involvement of the lysine residue present at the active site of Ehrlich ascites carcinoma (EAC) cell glyceraldehyde-3-phosphate dehydrogenase (Gra3PDH) was investigated by using the lysine specific reagents trinitrobenzenesulfonic acid (TNBS) and pyridoxal phosphate (PP).	Lysine	23-29	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	147-154
11732997-2	2001	The involvement of the lysine residue present at the active site of Ehrlich ascites carcinoma (EAC) cell glyceraldehyde-3-phosphate dehydrogenase (Gra3PDH) was investigated by using the lysine specific reagents trinitrobenzenesulfonic acid (TNBS) and pyridoxal phosphate (PP).	Lysine	186-192	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	105-145
11732997-2	2001	The involvement of the lysine residue present at the active site of Ehrlich ascites carcinoma (EAC) cell glyceraldehyde-3-phosphate dehydrogenase (Gra3PDH) was investigated by using the lysine specific reagents trinitrobenzenesulfonic acid (TNBS) and pyridoxal phosphate (PP).	Lysine	186-192	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	147-154
25049232-7	2014	Mutation of the highly conserved Lys-774 residue induced hypermorphic phenotypes that mimicked the loss of phosphorylation control; mutation of the corresponding codon of the human RBL2 gene has been reported in lung tumors.	Lysine	33-36	RB transcriptional corepressor like 2	Homo sapiens	181-185
15805167-2	2005	We substituted residue S1759 (serine), a putative D4S6 gating hinge of human cardiac hNav1.5 Na(+) channels with A (alanine), D (aspartate), K (lysine), L (leucine), P (proline), and W (tryptophan).	Lysine	144-150	sodium voltage-gated channel alpha subunit 5	Homo sapiens	85-92
25007327-13	2014	Expression of a PEX3 mutant with substitution of all lysine and cysteine residues by arginine and alanine, respectively, also induces peroxisome ubiquitination and degradation, hence suggesting that ubiquitination of PEX3 is dispensable for pexophagy and an endogenous, unidentified peroxisomal protein is ubiquitinated on the peroxisomal membrane.	Lysine	53-59	peroxisomal biogenesis factor 3	Homo sapiens	16-20
11726274-1	2001	As models of ion channel proteins and naturally occurring pore-forming peptides, we designed a series of Aib rich peptides [Ac-(Aib-Xxx-Aib-Ala)(5)-NH(2) (Xxx = Lys, Glu, Ser, and Gly: BXBA-20)] to investigate the effects of the side chains of the amino acid residues Lys, Glu, Ser, and Gly on the conformation and electrophysiological properties of ion channels.	Lysine	161-164	ANIB1	Homo sapiens	105-108
11726274-1	2001	As models of ion channel proteins and naturally occurring pore-forming peptides, we designed a series of Aib rich peptides [Ac-(Aib-Xxx-Aib-Ala)(5)-NH(2) (Xxx = Lys, Glu, Ser, and Gly: BXBA-20)] to investigate the effects of the side chains of the amino acid residues Lys, Glu, Ser, and Gly on the conformation and electrophysiological properties of ion channels.	Lysine	268-271	ANIB1	Homo sapiens	105-108
24703936-3	2014	Here we report that Jmjd3, a histone H3 lysine 27 (H3K27) demethylase, is highly inducible in SAA-stimulated macrophages and plays an important role in the induction of inflammatory cytokine genes.	Lysine	40-46	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	20-25
15821163-6	2005	For thioredoxin Asp-26, which has a large pK(a) upshift, we correctly capture the balance between unfavorable carboxylate desolvation and favorable interactions with a nearby lysine; similarly for RNase A Asp-14, which has a large pK(a) downshift.	Lysine	175-181	thioredoxin	Homo sapiens	4-15
24703936-3	2014	Here we report that Jmjd3, a histone H3 lysine 27 (H3K27) demethylase, is highly inducible in SAA-stimulated macrophages and plays an important role in the induction of inflammatory cytokine genes.	Lysine	40-46	serum amyloid A cluster	Mus musculus	94-97
24760768-2	2014	CDKAL1 catalyzes 2-methylthio modification of adenosine at position 37 of tRNA(Lys)(UUU).	Lysine	79-82	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	0-6
11544250-1	2001	In all eukaryotes, multisubunit histone acetyltransferase (HAT) complexes acetylate the highly conserved lysine residues in the amino-terminal tails of core histones to regulate chromatin structure and gene expression.	Lysine	105-111	histone acetyltransferase	Saccharomyces cerevisiae S288C	32-57
11544250-1	2001	In all eukaryotes, multisubunit histone acetyltransferase (HAT) complexes acetylate the highly conserved lysine residues in the amino-terminal tails of core histones to regulate chromatin structure and gene expression.	Lysine	105-111	histone acetyltransferase	Saccharomyces cerevisiae S288C	59-62
11588219-6	2001	However, a beta2AR mutant lacking lysine residues, which was not ubiquitinated, was internalized normally but was degraded ineffectively.	Lysine	34-40	adrenoceptor beta 2	Homo sapiens	11-18
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-218	annexin A2	Homo sapiens	34-44
11679080-7	2001	The expression of several genes encoding enzymes in amino acid biosynthetic pathways, including the branched-chain, lysine and arginine, and the sulphur amino acid biosynthetic pathways, are modulated by Ssy1p.	Lysine	116-122	Ssy1p	Saccharomyces cerevisiae S288C	204-209
25016022-6	2014	Mutagenesis of two N-terminal lysine residues (K4R and K6R) inhibited ZnT2 ubiquitination, vesicular zinc accumulation and secretion, and protein degradation.	Lysine	30-36	solute carrier family 30 member 2	Homo sapiens	70-74
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-217	annexin A2	Homo sapiens	34-44
15916951-0	2005	The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.	Lysine	72-78	embryonic ectoderm development	Mus musculus	34-37
25153170-4	2014	Enhancer of zeste homolog 2 (Ezh2), a key component of polycomb group proteins, catalyzes tri-methylation of lysine 27 of histone H3 (H3K27me3), which trigger the gene suppression.	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
25153170-4	2014	Enhancer of zeste homolog 2 (Ezh2), a key component of polycomb group proteins, catalyzes tri-methylation of lysine 27 of histone H3 (H3K27me3), which trigger the gene suppression.	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
11553772-3	2001	We show here that adenovirus type 5 early region 1B 55-kDa (E1B-55kDa) oncoprotein can be covalently modified by SUMO-1 in vivo through a major attachment site comprising a single lysine residue at amino acid position 104.	Lysine	180-186	small ubiquitin-like modifier 1	Rattus norvegicus	113-119
11553772-4	2001	The sequence surrounding this lysine matches the proposed PsiKxE consensus motif required for SUMO-1 conjugation.	Lysine	30-36	small ubiquitin-like modifier 1	Rattus norvegicus	94-100
15907489-5	2005	Mutation of the lysine (K)-378 to arginine (R) (K378R) abolished the interaction with TbetaR-I, phosphorylation, transcriptional activation by an active TbetaR-I.	Lysine	16-22	transforming growth factor beta receptor 1	Homo sapiens	86-94
11432854-2	2001	The conserved lysine in the Walker A motif of the ATP-binding domain encoded by the yeast RFC1, RFC2, RFC3, and RFC4 genes was mutated to glutamic acid.	Lysine	14-20	replication factor C subunit 1	Saccharomyces cerevisiae S288C	90-94
11432854-2	2001	The conserved lysine in the Walker A motif of the ATP-binding domain encoded by the yeast RFC1, RFC2, RFC3, and RFC4 genes was mutated to glutamic acid.	Lysine	14-20	replication factor C subunit 2	Saccharomyces cerevisiae S288C	96-100
25131202-3	2014	Here, we show that BRCA1/BARD1 specifically ubiquitylates histone H2A in its C-terminal tail on lysines 127 and 129 in vitro and in vivo.	Lysine	96-103	BRCA1 DNA repair associated	Homo sapiens	19-24
25131202-3	2014	Here, we show that BRCA1/BARD1 specifically ubiquitylates histone H2A in its C-terminal tail on lysines 127 and 129 in vitro and in vivo.	Lysine	96-103	BRCA1 associated RING domain 1	Homo sapiens	25-30
11432854-9	2001	Mutant RFC complexes containing rfc2-K71R or rfc3-K59R, carrying a conservative lysine --&gt; arginine mutation, had much milder clamp loading defects that could be partially (rfc2-K71R) or completely (rfc3-K59R) suppressed at high ATP concentrations.	Lysine	80-86	replication factor C subunit 2	Saccharomyces cerevisiae S288C	32-36
15907489-5	2005	Mutation of the lysine (K)-378 to arginine (R) (K378R) abolished the interaction with TbetaR-I, phosphorylation, transcriptional activation by an active TbetaR-I.	Lysine	16-22	transforming growth factor beta receptor 1	Homo sapiens	153-161
24958724-7	2014	We also demonstrate that mutation of Lys-443 and Tyr-474 in RIP2 disrupted the interaction with NOD1.	Lysine	37-40	receptor interacting serine/threonine kinase 2	Homo sapiens	60-64
15907489-9	2005	Thus, the lysine residues of Smad3 MH2 domain play important roles in the transcriptional regulation of TGF-beta signals through TbetaR-I.	Lysine	10-16	transforming growth factor beta receptor 1	Homo sapiens	129-137
11478886-0	2001	Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase.	Lysine	41-44	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	78-82
15929701-3	2005	Amino acid substitution at 264 from arginine (R) to glycine (G), lysine (K), or threonine (T) results in a low affinity peptide that binds to HLA-B27 inefficiently and is poorly recognized by T cells that respond to the wild-type peptide.	Lysine	65-71	major histocompatibility complex, class I, B	Homo sapiens	142-149
11498590-3	2001	We show that the accurate execution of the IFN-beta transcriptional switch depends on the ordered acetylation of the high-mobility group I protein HMGI(Y) by PCAF/GCN5 and CBP, which acetylate HMGI(Y) at distinct lysine residues on endogenous promoters.	Lysine	213-219	lysine acetyltransferase 2A	Homo sapiens	163-167
11498590-4	2001	Whereas acetylation of HMGI(Y) by CBP at lysine-65 destabilizes the enhanceosome, acetylation of HMGI(Y) by PCAF/GCN5 at lysine-71 potentiates transcription by stabilizing the enhanceosome and preventing acetylation by CBP.	Lysine	121-127	lysine acetyltransferase 2A	Homo sapiens	113-117
25105474-1	2014	Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9.	Lysine	40-46	jumonji, AT rich interactive domain 2	Mus musculus	0-6
24747578-1	2014	Sirtuin 1 (SIRT1) is the most studied human sirtuin and it catalyzes the deacetylation reaction of acetylated lysine residues of its target proteins, for example histones.	Lysine	110-116	sirtuin 1	Homo sapiens	0-9
24747578-1	2014	Sirtuin 1 (SIRT1) is the most studied human sirtuin and it catalyzes the deacetylation reaction of acetylated lysine residues of its target proteins, for example histones.	Lysine	110-116	sirtuin 1	Homo sapiens	11-16
11316813-0	2001	Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.	Lysine	148-155	euchromatic histone lysine methyltransferase 2	Homo sapiens	31-34
11316813-4	2001	Like Suv39 h1, the first identified lysine-preferring mammalian HMTase, G9a transfers methyl groups to the lysine residues of histone H3, but with a 10-20-fold higher activity.	Lysine	36-42	euchromatic histone lysine methyltransferase 2	Homo sapiens	72-75
11316813-6	2001	G9a was able to add methyl groups to lysine 27 as well as 9 in H3, compared with Suv39 h1, which was only able to methylate lysine 9.	Lysine	37-43	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
11316813-6	2001	G9a was able to add methyl groups to lysine 27 as well as 9 in H3, compared with Suv39 h1, which was only able to methylate lysine 9.	Lysine	124-130	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
15831463-6	2005	Mutation of these lysines affects MEF2 DNA binding and transcriptional activity, as well as its synergistic effect with myogenin in myogenic conversion assays.	Lysine	18-25	myogenin	Mus musculus	120-128
11342552-5	2001	In the current study, we have investigated the involvement of Lys-7, Gln-11, Asn-71, Asn-88, Gly-89, Ser-90, and Glu-111 in HPR in its interaction with human ribonuclease inhibitor.	Lysine	62-65	ribonuclease/angiogenin inhibitor 1	Homo sapiens	158-180
15713663-12	2005	Chromatin immunoprecipitation assay demonstrated that cyclin D1 enhanced recruitment of HDAC1 and HDAC3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H3 and histone H3 lysine 9.	Lysine	267-273	histone deacetylase 1	Mus musculus	88-93
11343278-2	2001	In the attempt to synthesize cross-linked elastin-mimetic polypeptides, the repeating sequence VGGVG (V: valine; G: glycine), typical of elastin, was modified to incorporate lysine residues, yielding the polymer poly(KGGVG) (K: lysine).	Lysine	174-180	elastin	Homo sapiens	42-49
11343278-2	2001	In the attempt to synthesize cross-linked elastin-mimetic polypeptides, the repeating sequence VGGVG (V: valine; G: glycine), typical of elastin, was modified to incorporate lysine residues, yielding the polymer poly(KGGVG) (K: lysine).	Lysine	228-234	elastin	Homo sapiens	42-49
24842928-0	2014	Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.	Lysine	18-24	Y box protein 3	Mus musculus	62-66
24842928-2	2014	Lysines K82, K163, and K170 of DbpA are known to be important for in vitro interaction with decorin, and the DbpA structure, initially solved by nuclear magnetic resonance (NMR) spectroscopy, suggests these lysine residues colocalize in a pocket near the C terminus of the protein.	Lysine	0-7	Y box protein 3	Mus musculus	31-35
24842928-2	2014	Lysines K82, K163, and K170 of DbpA are known to be important for in vitro interaction with decorin, and the DbpA structure, initially solved by nuclear magnetic resonance (NMR) spectroscopy, suggests these lysine residues colocalize in a pocket near the C terminus of the protein.	Lysine	207-213	Y box protein 3	Mus musculus	31-35
24842928-2	2014	Lysines K82, K163, and K170 of DbpA are known to be important for in vitro interaction with decorin, and the DbpA structure, initially solved by nuclear magnetic resonance (NMR) spectroscopy, suggests these lysine residues colocalize in a pocket near the C terminus of the protein.	Lysine	207-213	Y box protein 3	Mus musculus	109-113
24842928-9	2014	Taken together, these data showed that lysines K82, K163, and K170 potentiate the binding of DbpA to dermatan sulfate and that an interaction(s) mediated by these lysines is essential for B. burgdorferi murine infection.	Lysine	39-46	Y box protein 3	Mus musculus	93-97
24842928-9	2014	Taken together, these data showed that lysines K82, K163, and K170 potentiate the binding of DbpA to dermatan sulfate and that an interaction(s) mediated by these lysines is essential for B. burgdorferi murine infection.	Lysine	163-170	Y box protein 3	Mus musculus	93-97
15713663-12	2005	Chromatin immunoprecipitation assay demonstrated that cyclin D1 enhanced recruitment of HDAC1 and HDAC3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H3 and histone H3 lysine 9.	Lysine	267-273	histone deacetylase 3	Mus musculus	98-103
11416128-3	2001	Ubiquitination of Fur4p occurs on two target lysines, which receive two ubiquitin moieties linked through ubiquitin Lys63, a type of linkage (termed UbK63) different from that involved in proteasome recognition.	Lysine	45-52	uracil permease	Saccharomyces cerevisiae S288C	18-23
15713663-12	2005	Chromatin immunoprecipitation assay demonstrated that cyclin D1 enhanced recruitment of HDAC1 and HDAC3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H3 and histone H3 lysine 9.	Lysine	267-273	suppressor of variegation 3-9 1	Mus musculus	134-141
25074452-16	2014	1, increasing CP and Lys resulted in a quadratic increase (P &lt; 0.05) in ADG and a linear improvement (P &lt; 0.05) in G:F during the 14-d treatment period.	Lysine	21-24	ADG	Sus scrofa	75-78
15713679-5	2005	After producing and purifying recombinant hK5 in yeast, we determined the k(cat)/K(m) ratio of the fluorogenic substrates Gly-Pro-Arg-AMC and Gly-Pro-Lys-AMC, and showed that it has trypsin-like activity with strong preference for Arg over Lys in the P1 position.	Lysine	150-153	keratin 5	Homo sapiens	42-45
25074452-17	2014	Breakpoint regression analyses revealed that optimum ADG was obtained at 1.36% Lys, while optimum G:F was obtained at 1.45% Lys.	Lysine	79-82	ADG	Sus scrofa	53-56
25074452-20	2014	2, both ADG and G:F increased linearly (P &lt; 0.05) with increasing Lys.	Lysine	69-72	ADG	Sus scrofa	8-11
25074452-21	2014	Optimal ADG was obtained at 1.47% Lys, but the breakpoint for optimum G:F was above tested levels.	Lysine	34-37	ADG	Sus scrofa	8-11
11415939-7	2001	At 14 d after incubation with rhTE, the ratio of DES and IDES radioactivity to that of lysine in the insoluble elastin was 0.38.	Lysine	87-93	elastin	Rattus norvegicus	111-118
15829403-5	2005	The B13 S15.4 peptide-specific CD4+ T-cell clone 3E5 was tested in proliferation assays against 15 Lys/His-substituted S15.4-derived peptides for TCR/HLA contact analysis.	Lysine	99-102	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	4-7
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Lysine	97-103	Aspartate kinase family protein	Arabidopsis thaliana	0-16
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Lysine	97-103	Aspartate kinase family protein	Arabidopsis thaliana	18-20
25009642-2	2014	Astrocyte elevated gene-1 [AEG-1; also known as Metadherin (MTDH) and Lysine-rich CEACAM1 co-isolated (LYRIC)] has emerged in recent years as a potentially crucial mediator of tumor malignancy, and a key converging point of a complex network of oncogenic signaling pathways.	Lysine	70-76	CEA cell adhesion molecule 1	Homo sapiens	82-89
24971742-1	2014	The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-KDM4D), which selectively remove the methyl group(s) from tri/dimethylated lysine 9/36 of H3, modulate transcriptional activation and genome stability.	Lysine	44-50	lysine demethylase 4A	Homo sapiens	9-14
24971742-1	2014	The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-KDM4D), which selectively remove the methyl group(s) from tri/dimethylated lysine 9/36 of H3, modulate transcriptional activation and genome stability.	Lysine	44-50	lysine demethylase 4A	Homo sapiens	65-70
11328597-11	2001	Use of phosphopeptide substrates also revealed that poly-L-lysine, an activator for CaMKPase, activated the enzyme mainly through increase in the V(max) values.	Lysine	52-65	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	84-92
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Lysine	218-221	crystallin, gamma B	Mus musculus	64-67
15750349-6	2005	R75 stimulated the catalytic activity of CKII whereas R26 gave little stimulation, and poly-L-lysine increased the stimulation of catalytic activity by R26 or R75.	Lysine	87-100	casein kinase 2 alpha 1	Homo sapiens	41-45
11134034-8	2001	Similarly, mutation of Lys(304), which mediates the CREB interaction with the hydrated Mg(2+), blocked CREB binding to the palindromic but not the variant CRE sequences.	Lysine	23-26	cAMP responsive element binding protein 1	Homo sapiens	52-56
11134034-8	2001	Similarly, mutation of Lys(304), which mediates the CREB interaction with the hydrated Mg(2+), blocked CREB binding to the palindromic but not the variant CRE sequences.	Lysine	23-26	cAMP responsive element binding protein 1	Homo sapiens	103-107
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Lysine	78-85	bromodomain containing 3	Homo sapiens	109-113
25097667-6	2014	RESULTS: Mutation of a conserved asparagine crucial for binding to acetylated lysines in the bromodomains of BRD3, BRD4 and TRIM24 all resulted in reduction of FRAP recovery times, indicating loss of or significantly reduced binding to acetylated chromatin, as did the addition of known inhibitors.	Lysine	78-85	tripartite motif containing 24	Homo sapiens	124-130
15670565-1	2005	In a 7-week-old infant who experienced sudden infant death syndrome (SIDS), a novel missense mutation was identified in KCNH2, causing a lysine-to-glutamic acid amino acid substitution at position 101 (K101E).	Lysine	137-143	potassium voltage-gated channel subfamily H member 2	Homo sapiens	120-125
24935251-6	2014	Histone acetylation (primary MoA) increased quickly and returned to baseline after 48 h. Histone H3 lysine methylation at the promoter of the neurodevelopmental regulators PAX6 or OTX2 was increasingly altered over time.	Lysine	100-106	orthodenticle homeobox 2	Homo sapiens	180-184
24924415-5	2014	LSD2-KD led to accumulation of H3K4me1/2 without changing methylation levels of other key histone lysine residues, suggesting that LSD2 acts as a bona fide H3K4 demethylase in breast cancer cells.	Lysine	98-104	lysine demethylase 1B	Homo sapiens	0-7
11287151-0	2001	Characterization of the active-site residues asparagine 167 and lysine 161 of the IMP-1 metallo beta-lactamase.	Lysine	64-70	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	82-87
11327829-13	2001	The implications of the determined consensus substrate sequence (Arg/Lys)/(Arg/Lys)-Ala for the proposed biological function of OmpT in defense against antimicrobial peptides are discussed.	Lysine	69-72	outer membrane protease	Escherichia coli	128-132
11327829-13	2001	The implications of the determined consensus substrate sequence (Arg/Lys)/(Arg/Lys)-Ala for the proposed biological function of OmpT in defense against antimicrobial peptides are discussed.	Lysine	79-82	outer membrane protease	Escherichia coli	128-132
24924415-5	2014	LSD2-KD led to accumulation of H3K4me1/2 without changing methylation levels of other key histone lysine residues, suggesting that LSD2 acts as a bona fide H3K4 demethylase in breast cancer cells.	Lysine	98-104	lysine demethylase 1B	Homo sapiens	0-4
15654753-4	2005	In particular, we monitored surface accessibility of RPA lysines with NHS-biotin modification in the contexts of the free protein and the nucleoprotein complex.	Lysine	57-64	replication protein A1	Homo sapiens	53-56
24652950-2	2014	This study explored the role of G9a- and enhancer of zeste homolog 2 (EZH2)-mediated methylation of histone H3 lysine 9 (H3K9me3) and histone H3 lysine 27 (H3K27me3) in COX-2 silencing in IPF.	Lysine	111-117	euchromatic histone lysine methyltransferase 2	Homo sapiens	32-68
11172676-1	2001	Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins.	Lysine	172-179	histone deacetylase 9	Homo sapiens	0-19
11172676-1	2001	Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins.	Lysine	172-179	histone deacetylase 9	Homo sapiens	21-25
15654753-10	2005	We propose that the protection of these lysines could result from the RPA interdomain structural reorganization induced by ssDNA binding.	Lysine	40-47	replication protein A1	Homo sapiens	70-73
15501826-8	2005	Certain lysine mutations in H2A alleviate the transcriptional defect in spt10 Delta strains, though CUP1 activation is still delayed in these mutants; however, CUP1 shutdown is normal.	Lysine	8-14	Spt10p	Saccharomyces cerevisiae S288C	72-77
11230714-0	2001	A case of late onset cardiac amyloidosis with a new transthyretin variant (lysine 92).	Lysine	75-81	transthyretin	Homo sapiens	52-65
24687155-2	2014	The lysine-specific demethylase LSD1 (KDM1A/AOF2) demethylates in vitro predominantly mono- and dimethylated lysine 4 on histone 3 (H3K4) and is a promising target for drug discovery.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	32-36
24687155-2	2014	The lysine-specific demethylase LSD1 (KDM1A/AOF2) demethylates in vitro predominantly mono- and dimethylated lysine 4 on histone 3 (H3K4) and is a promising target for drug discovery.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	38-43
24687155-2	2014	The lysine-specific demethylase LSD1 (KDM1A/AOF2) demethylates in vitro predominantly mono- and dimethylated lysine 4 on histone 3 (H3K4) and is a promising target for drug discovery.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	44-48
24687155-4	2014	We used a biotinylated histone 3 peptide (amino acids 1-21) with monomethylated lysine 4 (H3K4me) as the substrate for the detection of LSD1 activity with antibody-mediated quantitation of the demethylated product.	Lysine	80-86	lysine demethylase 1A	Homo sapiens	136-140
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Lysine	25-28	sodium/proton exchanger	Hordeum vulgare	79-85
24732914-7	2014	The structure revealed a unique bent substrate binding mode positioning the histone H3 residues Arg(2) and Lys(4) adjacent to the Haspin phosphorylated threonine into acidic binding pockets.	Lysine	107-110	histone H3 associated protein kinase	Homo sapiens	130-136
24732914-8	2014	This unique conformation of the kinase-substrate complex explains the reported modulation of Haspin activity by methylation of Lys(4) of the histone H3.	Lysine	127-130	histone H3 associated protein kinase	Homo sapiens	93-99
24983519-3	2014	Pilocarpine drove a 20-fold increase in mRNA encoding the histone H3 lysine 27-specific demethylase Kdm6b selectively in granule neurons of the dentate gyrus, and this induction was recapitulated in cultured hippocampal neurons by bicuculline and 4-aminopyridine (Bic + 4AP) stimulation of synaptic activity.	Lysine	69-75	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	100-105
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Lysine	136-139	protein kinase C zeta	Homo sapiens	51-72
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Lysine	136-139	protein kinase C zeta	Homo sapiens	74-82
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Lysine	136-139	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	140-143
11145717-5	2001	Extensive biotinylation ( approximately 15 biotins/molecule protein) of lysine residues on the surface of purified, native TPO resulted in loss of multiple tryptic cleavage sites, as determined by analysis of tryptic polypeptide fragments on reverse-phase HPLC.	Lysine	72-78	thyroid peroxidase	Homo sapiens	123-126
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Lysine	25-28	sodium/proton exchanger	Hordeum vulgare	195-201
11145717-9	2001	The epitope-protected lysine (K) was present in a 30-aa TPO fragment that, by N-terminal sequencing, was found to be K713.	Lysine	22-28	thyroid peroxidase	Homo sapiens	56-59
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Lysine	29-32	sodium/proton exchanger	Hordeum vulgare	79-85
15701055-8	2005	The 14-3-3-binding motif Lys-Lys-Glu-Ser-His-Pro (371-376) was detected in the HvNHX2 amino acid sequence, which is suggestive of possible involvement of the 14-3-3 proteins in the regulation of HvNHX2 function.	Lysine	29-32	sodium/proton exchanger	Hordeum vulgare	195-201
11042198-6	2001	Based on this model, two residues (Lys-183 and Asp-217) in the regulatory IDH1 subunit were predicted to be important in the catalytic site of IDH2.	Lysine	35-38	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	143-147
15611636-2	2005	Here we show that p63alpha, but not p63beta and gamma, is sumoylated in vitro and in vivo at a single lysine residue, K637, in the post-SAM domain.	Lysine	102-108	tumor protein p63	Homo sapiens	18-26
11042198-8	2001	Also based on this model, the two analogous residues (Lys-189 and Asp-222) of the catalytic IDH2 subunit were predicted to contribute to the regulatory site of IDH1.	Lysine	54-57	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	92-96
11460477-3	2001	There was no competition with the crosslinking of alpha 2-antiplasmin, another inhibitor of fibrinolysis, which was specific for Lys 303 in the A alpha chain.	Lysine	129-132	serpin family F member 2	Homo sapiens	50-69
24813945-3	2014	We show that UHRF1 exists in distinct active states, binding either unmodified H3 or the H3 lysine 9 trimethylation (H3K9me3) modification.	Lysine	92-98	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	13-18
24813946-5	2014	We identified an RNA binding motif referred to as "clasp" as well as a conformational switch that involves the essential Walker A lysine (Lys127) and regulates the enzymatic activity of ceClp1.	Lysine	130-136	Calpain clp-1	Caenorhabditis elegans	186-192
11135081-5	2001	The binding characteristics of IgA1 to HMCs in the presence of polycation (poly-L-lysine) or polyanion (heparin) were also investigated.	Lysine	75-88	immunoglobulin heavy constant alpha 1	Homo sapiens	31-35
15598983-3	2005	DCL1 is also required for methylation of histone H3 at Lys 9, which, in wild-type cells, specifically occurs on the sequences (IESs) being eliminated.	Lysine	55-58	CD302 molecule	Homo sapiens	0-4
11093806-1	2000	Transglutaminase-3 (TGase-3) is an enzyme with the ability to catalyze the irreversible cross-linking of peptide-bound glutamine residues either with peptide-bound lysines or with primary amines.	Lysine	164-171	transglutaminase 3	Homo sapiens	0-27
24835590-4	2014	Disruption of the sumoylation pathway by knockdown of sumoylation enzymes, mutation of the SUMO-target lysine of TFAP2A, or treatment with sumoylation inhibitors induced a basal-to-luminal transition, which was dependent on TFAP2A.	Lysine	103-109	transcription factor AP-2 alpha	Homo sapiens	113-119
24242335-7	2014	In contrast, the increased tumor incidence in mice treated with DEN+CCl4 was associated with marked epigenetic changes in liver tumors and nontumor liver tissue, including demethylation of genomic DNA and repetitive elements, a decrease in histone 3 lysine 9 trimethylation (H3K9me3) and promoter hypermethylation and functional downregulation of Riz1, a histone lysine methyltransferase tumor suppressor gene.	Lysine	250-256	chemokine (C-C motif) ligand 4	Mus musculus	68-72
15826377-2	2005	We determined the crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the conserved core of lysine-type PGNs.	Lysine	166-172	peptidoglycan recognition protein 3	Homo sapiens	82-93
24680668-2	2014	Dimethylation of H3K4 requires a sub-complex including WRAD (WDR5, RbBP5, Ash2L, and DPY-30), which binds to each SET1 family member forming a minimal core complex that is required for multiple lysine methylation.	Lysine	194-200	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	74-79
11087837-3	2000	Here, we show that despite the comparable expression of I-A(b)-peptide complex in the thymus, this substitution from leucine to lysine affects efficiency of positive selection, resulting in extremely small numbers of CD4(+) T cells to be selected to mature on I-A(b)-(p)60K complex.	Lysine	128-134	CD4 antigen	Mus musculus	217-220
24680668-2	2014	Dimethylation of H3K4 requires a sub-complex including WRAD (WDR5, RbBP5, Ash2L, and DPY-30), which binds to each SET1 family member forming a minimal core complex that is required for multiple lysine methylation.	Lysine	194-200	dpy-30 histone methyltransferase complex regulatory subunit	Homo sapiens	85-91
15632065-1	2005	Rad6-mediated ubiquitylation of histone H2B at lysine 123 has been linked to transcriptional activation and the regulation of lysine methylation on histone H3.	Lysine	47-53	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	0-4
24918286-7	2014	Notably, FOXM1B is selectively SUMOylated at lysine residue 463.	Lysine	45-51	forkhead box M1	Homo sapiens	9-15
11120354-3	2000	A lysine residue conserved between all DYRK kinase family members was found to be essential for the kinase function of HIPK2.	Lysine	2-8	homeodomain interacting protein kinase 2	Homo sapiens	119-124
15632065-1	2005	Rad6-mediated ubiquitylation of histone H2B at lysine 123 has been linked to transcriptional activation and the regulation of lysine methylation on histone H3.	Lysine	126-132	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	0-4
11094089-0	2000	Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.	Lysine	9-15	MDM2 proto-oncogene	Homo sapiens	73-77
15620648-9	2004	We map the site of NEMO ubiquitinylation to a novel NEMO ubiquitinylation site (Lysine 285) and show that this ubiquityinylation occurs in vivo.	Lysine	80-86	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	19-23
11054123-9	2000	The distinct Arg/Lys-rich and Met-rich region at positions 10-36 of the PLA2 homolog presumably are involved in its heparin-binding and the cell membrane-interference leading to edema and myotoxicity.	Lysine	17-20	phospholipase A2 group IIA	Homo sapiens	72-76
24519555-7	2014	For comparison, (125)I-BH-exendin(9-39) with the BH labelled at lysine 4 did identify the GLP-1 receptor in rat tissues but not in human tissues.	Lysine	64-70	glucagon-like peptide 1 receptor	Rattus norvegicus	90-104
10987435-2	2000	Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 microM) affinity for EBP; "dimerization" of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 microM binding affinities.	Lysine	57-63	EBP cholestenol delta-isomerase	Homo sapiens	111-114
15620648-9	2004	We map the site of NEMO ubiquitinylation to a novel NEMO ubiquitinylation site (Lysine 285) and show that this ubiquityinylation occurs in vivo.	Lysine	80-86	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	52-56
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	41-44	ubiquitin conjugating enzyme E2 N	Homo sapiens	95-100
10949293-3	2000	Here we show that human SUV39H1 and murine Suv39h1--mammalian homologues of Drosophila Su(var)3-9 and of Schizosaccharomyces pombe clr4--encode histone H3-specific methyltransferases that selectively methylate lysine 9 of the amino terminus of histone H3 in vitro.	Lysine	210-216	Suppressor of variegation 3-9	Drosophila melanogaster	87-97
10924141-7	2000	Substitution of the aligned lysine and proline residues does, however, reduce structural stability, consistent with a temperature sensitive phenotype that results from substitution of the cognate proline residue in Cbf5p, a yeast homologue of TruB [Zerbarjadian, Y., King, T., Fournier, M. J., Clarke, L., and Carbon, J.	Lysine	28-34	pseudouridine synthase CBF5	Saccharomyces cerevisiae S288C	215-220
24876389-8	2014	Cat1 undergoes ubiquitinations on lysine residues within the N-terminus, which are mediated, in part, by Arn1 to determine Cat1 localization.	Lysine	34-40	siderophore transporter	Saccharomyces cerevisiae S288C	105-109
24886859-0	2014	Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.	Lysine	67-73	lysine demethylase 1A	Homo sapiens	0-29
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	41-44	ubiquitin conjugating enzyme E2 V1	Homo sapiens	101-106
24886859-0	2014	Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.	Lysine	67-73	prostaglandin E synthase	Homo sapiens	117-154
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	255-258	ubiquitin conjugating enzyme E2 N	Homo sapiens	95-100
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	255-258	ubiquitin conjugating enzyme E2 V1	Homo sapiens	101-106
10959596-2	2000	Both the 2-chlorobenzyloxycarbonyl (CIZ) group for Lys and methyl (Me) for phosphoamino acids remained intact, while other commonly used side-chain protecting groups were cleaved quantitatively, during the reaction using a highly acidic trifluoromethanesulfonic acid (TFMSA)-based reagent system (High TFMSA: TFMSA-TFA-m-cresol=1:9:1, v/v).	Lysine	51-54	zinc finger protein 384	Homo sapiens	36-39
15557191-10	2004	These results indicate that the extracellular TLR4 domain-MD-2 complex is capable of binding LPS, and that the extracellular TLR4 domain consisting of Glu(24)-Lys(631) enables MD-2 binding and LPS recognition to TLR4.	Lysine	159-162	toll like receptor 4	Homo sapiens	125-129
10891339-1	2000	Human alpha1--&gt;3/4fucosyltransferases (FucTs) contain a common essential pyridoxal-5"-phosphate(PLP)/NaBH(4) reactive, GDP-fucose-protectable Lys.	Lysine	145-148	proteolipid protein 1	Homo sapiens	99-102
10891339-13	2000	The third site, Lys(300), is involved in GDP-fucose binding and PLP/NaBH(4) inactivation.	Lysine	16-19	proteolipid protein 1	Homo sapiens	64-67
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	90-93	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24724799-8	2014	Moreover, ubiquitin chain cleavage assays with all eight linkages reveal a preference for Lys(63)-, Lys(6)-, Lys(33)-, and Lys(11)-linked chains over Lys(27)-, Lys(29)-, and Lys(48)-linked and linear chains consistent with USP11"s function in DNA repair pathways that is mediated by the protease domain.	Lysine	100-103	ubiquitin specific peptidase 11	Homo sapiens	223-228
24726732-2	2014	Histone methyltransferase EZH2 and histone demethylase JMJD3 (KDM6B) modulate levels of histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	99-105	lysine demethylase 6B	Homo sapiens	55-60
10748065-6	2000	Alanine mutagenesis within this motif demonstrated that the critical amino acids of triadin binding to calsequestrin are the even-numbered residues Lys(210), Lys(212), Glu(214), Lys(216), Gly(218), Gln(220), Lys(222), and Lys(224).	Lysine	158-161	triadin	Homo sapiens	84-91
10748065-6	2000	Alanine mutagenesis within this motif demonstrated that the critical amino acids of triadin binding to calsequestrin are the even-numbered residues Lys(210), Lys(212), Glu(214), Lys(216), Gly(218), Gln(220), Lys(222), and Lys(224).	Lysine	158-161	triadin	Homo sapiens	84-91
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Lysine	120-123	complement C1q A chain	Homo sapiens	238-241
10888497-4	2000	Structural analysis using monoclonal antibodies indicated that the conformation around (15)Val-(29)Ile (beta-sheet region) in beta-LG-GlcN and beta-LG-CPO had changed but that in beta-LG-CHS was maintained, whereas the conformation around (125)Thr-(135)Lys (alpha-helix region) in the conjugates had changed.	Lysine	253-256	beta-lactoglobulin	Bos taurus	126-133
10888497-4	2000	Structural analysis using monoclonal antibodies indicated that the conformation around (15)Val-(29)Ile (beta-sheet region) in beta-LG-GlcN and beta-LG-CPO had changed but that in beta-LG-CHS was maintained, whereas the conformation around (125)Thr-(135)Lys (alpha-helix region) in the conjugates had changed.	Lysine	253-256	beta-lactoglobulin	Bos taurus	143-150
10888497-4	2000	Structural analysis using monoclonal antibodies indicated that the conformation around (15)Val-(29)Ile (beta-sheet region) in beta-LG-GlcN and beta-LG-CPO had changed but that in beta-LG-CHS was maintained, whereas the conformation around (125)Thr-(135)Lys (alpha-helix region) in the conjugates had changed.	Lysine	253-256	beta-lactoglobulin	Bos taurus	143-150
15337770-7	2004	Although the cytoplasmic tail of IFNAR1 contains seven Lys residues that could function as potential ubiquitin acceptor sites, we found that only three (Lys501, Lys525, and Lys526), all located proximal to the destruction motif, are essential for ubiquitination and degradation of IFNAR1.	Lysine	55-58	interferon alpha and beta receptor subunit 1	Homo sapiens	33-39
10825373-4	2000	The NK(2) receptor-selective agonist, [Lys(5), MeLeu(9), Nle(10)]NKA(4-10), produced concentration-related contractile responses, while the respective NK(1) and NK(3) receptor-selective agonists, [Sar(9), Met(O(2))(11)]SP and [N-MePhe(7)]NKB, had no effect either in the absence or presence of the peptidase inhibitors.	Lysine	39-42	tachykinin receptor 2	Homo sapiens	4-18
24726732-2	2014	Histone methyltransferase EZH2 and histone demethylase JMJD3 (KDM6B) modulate levels of histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	99-105	lysine demethylase 6B	Homo sapiens	62-67
24816101-6	2014	However, a highly conserved lysine in O-sulfatases is replaced in SGSH by an arginine (Arg282) that is positioned to bind the N-linked sulfate substrate.	Lysine	28-34	N-sulfoglucosamine sulfohydrolase	Homo sapiens	66-70
15502305-3	2004	As crystallization efforts remained fruitless, even after the proteolysis-guided engineering of a truncated YopN polypeptide, reductive methylation of lysine residues was employed to alter the surface properties of the complex.	Lysine	151-157	outer membrane protein YopN (LcrE) homolog	Yersinia pestis	108-112
24604780-2	2014	Their locations are predominantly determined by the zinc finger protein PRDM9, which binds to DNA in hotspots and subsequently uses its SET domain to locally trimethylate histone H3 at lysine 4 (H3K4me3).	Lysine	185-191	PR domain containing 9	Mus musculus	72-77
10911986-0	2000	Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.	Lysine	119-125	lysine acetyltransferase 2A	Homo sapiens	90-94
15316021-5	2004	Because this cross-link contains two lysine residues and a dihydropyridinium ring, we assigned it the trivial name of K2P.	Lysine	37-43	keratin 76	Homo sapiens	118-121
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Lysine	108-111	ferritin light polypeptide 1	Mus musculus	122-132
24431009-1	2014	We have conducted biochemical studies with commercial available pyrroline-5-carboxylate (P5C) reductase (PYCR1) to investigate whether this enzyme plays a role in L-lysine degradation.	Lysine	163-171	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-87
24431009-1	2014	We have conducted biochemical studies with commercial available pyrroline-5-carboxylate (P5C) reductase (PYCR1) to investigate whether this enzyme plays a role in L-lysine degradation.	Lysine	163-171	pyrroline-5-carboxylate reductase 1	Homo sapiens	89-92
24431009-1	2014	We have conducted biochemical studies with commercial available pyrroline-5-carboxylate (P5C) reductase (PYCR1) to investigate whether this enzyme plays a role in L-lysine degradation.	Lysine	163-171	pyrroline-5-carboxylate reductase 1	Homo sapiens	105-110
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Lysine	108-111	ferritin light polypeptide 1	Mus musculus	187-197
10833409-6	2000	The difference was attributed to the substitution of a residue exposed on the cavity surface (Glu140 --&gt; Lys) in mouse L-ferritin, a hypothesis confirmed by the finding that the mouse L-ferritin mutant Lys140-Glu incorporated iron as efficiently as human L-ferritin.	Lysine	108-111	ferritin light polypeptide 1	Mus musculus	187-197
24678731-5	2014	NFIB controlled the expression of mammary-specific and STAT5-regulated genes and chromatin immunoprecipitation-sequencing established STAT5 and NFIB binding at composite regulatory elements containing histone H3 lysine dimethylation enhancer marks and progesterone receptor binding.	Lysine	212-218	nuclear factor I/B	Mus musculus	144-148
15492226-1	2004	TRAF6 (tumor necrosis factor receptor-associated factor 6) is a RING (really interesting new gene) domain ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys-63 of Ub.	Lysine	342-345	TNF receptor associated factor 6	Homo sapiens	0-5
24616100-7	2014	Biochemical analyses revealed that IRS1/2 decreased Lys-63-linked ubiquitination of Dvl2 and stabilized Dvl2 protein via suppressing its autophagy-mediated degradation.	Lysine	52-55	dishevelled segment polarity protein 2	Homo sapiens	84-88
10788439-4	2000	In contrast to ubiquitin, SUMO-1 preferentially targets a single lysine residue in c-Jun (Lys-229), and the abrogation of SUMO-1 modification does not compromise its ubiquitination.	Lysine	65-71	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
10788439-4	2000	In contrast to ubiquitin, SUMO-1 preferentially targets a single lysine residue in c-Jun (Lys-229), and the abrogation of SUMO-1 modification does not compromise its ubiquitination.	Lysine	90-93	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
24742640-3	2014	The histone demethylase JMJD1A activates gene transcription by demethylating the lysine 9 residue of histone H3 (H3K9) at target gene promoters.	Lysine	81-87	lysine demethylase 3A	Homo sapiens	24-30
15492226-1	2004	TRAF6 (tumor necrosis factor receptor-associated factor 6) is a RING (really interesting new gene) domain ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys-63 of Ub.	Lysine	342-345	TNF receptor associated factor 6	Homo sapiens	7-57
15492226-1	2004	TRAF6 (tumor necrosis factor receptor-associated factor 6) is a RING (really interesting new gene) domain ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys-63 of Ub.	Lysine	342-345	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	235-239
10797531-2	2000	We found that BDNF-promoted neuritogenesis was enhanced by forskolin in RGCs from rats at P2-P21 plated on either poly-L-lysine or collagen.	Lysine	114-127	brain-derived neurotrophic factor	Rattus norvegicus	14-18
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	143-149	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	122-125
15361854-3	2004	This study used site-specific antibodies to demonstrate that nerve growth factor (NGF) treatment of PC12 cells results in p53 deacetylation at lysine (Lys) 382.	Lysine	151-154	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	122-125
24567323-5	2014	Mutating a cluster of five lysines in this region largely eliminates Yku70 sumoylation.	Lysine	27-34	ATP-dependent DNA helicase YKU70	Saccharomyces cerevisiae S288C	69-74
15361854-9	2004	A model is proposed in which the acetylation status of Lys 382 of p53 discriminates between cell cycle arrest and apoptosis.	Lysine	55-58	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	66-69
24567323-6	2014	Chromatin immunoprecipitation analyses show that yku70 mutants with these lysines replaced by arginines exhibit reduced Ku-DNA association at both telomeres and internal DNA breaks.	Lysine	74-81	ATP-dependent DNA helicase YKU70	Saccharomyces cerevisiae S288C	49-54
10810161-12	2000	Lysine 177 could interact with the lysine-rich cluster involved in the specificity of protein kinase CK2 towards acidic substrate, thereby increasing its activity.	Lysine	0-6	Calcium-dependent protein kinase 6	Zea mays	101-104
15454444-5	2004	Moreover, the lysine-anchored L24 reduces the phase transition temperature, enthalpy, and the cooperativity of PE bilayers to a much greater extent than DAP-anchored L24DAP, whereas replacement of the terminal leucines by tryptophan residues (Ac-K2-W-L22-W-K2-amide) only slightly attenuates the effects of this peptide on the chain-melting phase transition of the host PE bilayers.	Lysine	14-20	ribosomal protein L22	Homo sapiens	251-254
10778740-8	2000	Although the functional C-terminal truncations disrupt the ATP-binding and active sites of Cdk2, reporter gene repression mediated by these truncated proteins is apparently due to phosphorylation of Pho4p, since a gene in which the essential lysine codon at position 33 was converted to an arginine codon does not complement the chromosomal gene disruption.	Lysine	242-248	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	199-204
24366338-1	2014	Lysine 63 (K63)-linked ubiquitination of RIG-I plays a critical role in the activation of type I interferon pathway, yet the molecular mechanism responsible for its deubiquitination is still poorly understood.	Lysine	0-6	DExD/H-box helicase 58	Homo sapiens	41-46
15519697-4	2004	Methylation of histone H3 lysine 9 and lysine 27 generates heterochromatin marks that are recognised through binding of heterochromatin proteins such as HP1.	Lysine	26-32	chromobox 5	Homo sapiens	153-156
24391131-4	2014	TRAF3, which was ubiquitinated (2.1-fold over control) at lys 48 position and subsequently degraded following LPS treatment, persisted in L. donovani and L. donovani + LPS costimulated cells due to defective lys 48 ubiquitination.	Lysine	58-61	TNF receptor-associated factor 3	Mus musculus	0-5
24391131-4	2014	TRAF3, which was ubiquitinated (2.1-fold over control) at lys 48 position and subsequently degraded following LPS treatment, persisted in L. donovani and L. donovani + LPS costimulated cells due to defective lys 48 ubiquitination.	Lysine	208-211	TNF receptor-associated factor 3	Mus musculus	0-5
27896080-1	2014	Pyridoxine dependent epilepsy (PDE) is caused by mutations in the ALDH7A1 gene (PDE-ALDH7A1) encoding alpha-aminoadipic-semialdehyde-dehydrogenase enzyme in the lysine catabolic pathway resulting in an accumulation of alpha-aminoadipic-acid-semialdehyde (alpha-AASA).	Lysine	161-167	aldehyde dehydrogenase 7 family member A1	Homo sapiens	66-73
27896080-1	2014	Pyridoxine dependent epilepsy (PDE) is caused by mutations in the ALDH7A1 gene (PDE-ALDH7A1) encoding alpha-aminoadipic-semialdehyde-dehydrogenase enzyme in the lysine catabolic pathway resulting in an accumulation of alpha-aminoadipic-acid-semialdehyde (alpha-AASA).	Lysine	161-167	aldehyde dehydrogenase 7 family member A1	Homo sapiens	84-91
27896080-1	2014	Pyridoxine dependent epilepsy (PDE) is caused by mutations in the ALDH7A1 gene (PDE-ALDH7A1) encoding alpha-aminoadipic-semialdehyde-dehydrogenase enzyme in the lysine catabolic pathway resulting in an accumulation of alpha-aminoadipic-acid-semialdehyde (alpha-AASA).	Lysine	161-167	aldehyde dehydrogenase 7 family member A1	Homo sapiens	102-146
10774743-3	2000	Incubation of GDH with increasing concentration of o-phthalaldehyde resulted in a progressive decrease in enzyme activity, suggesting that the o-phthalaldehyde-modified lysine or cysteine is directly involved in catalysis.	Lysine	169-175	Glu/Leu/Phe/Val dehydrogenase	Saccharolobus solfataricus	14-17
10693811-4	2000	Deacetylation of lysine 16 of H4 is necessary for binding the silencing protein, Sir3.	Lysine	17-23	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	81-85
15519697-4	2004	Methylation of histone H3 lysine 9 and lysine 27 generates heterochromatin marks that are recognised through binding of heterochromatin proteins such as HP1.	Lysine	39-45	chromobox 5	Homo sapiens	153-156
10652320-10	2000	Interestingly, further study suggested that certain basic residues of this site, particularly Arg(165) and Lys(169), play key roles in factor Va and/or prothrombin recognition by FXa in prothrombinase.	Lysine	107-110	coagulation factor X	Homo sapiens	179-182
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Lysine	165-171	carboxypeptidase B2 (plasma)	Mus musculus	0-18
10652320-10	2000	Interestingly, further study suggested that certain basic residues of this site, particularly Arg(165) and Lys(169), play key roles in factor Va and/or prothrombin recognition by FXa in prothrombinase.	Lysine	107-110	coagulation factor X	Homo sapiens	186-200
10639328-2	2000	The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation.	Lysine	148-151	neurofilament medium chain	Homo sapiens	32-36
24616512-4	2014	A point mutation in an evolutionarily conserved lysine-rich domain encoded by the alternatively spliced Zfp318 exon 10 abolished IgD expression on marginal zone B cells, decreased IgD on follicular B cells, and increased IgM, but only slightly decreased the percentage of B cells and did not decrease expression of other maturation markers CD21, CD23, or CD62L.	Lysine	48-54	zinc finger protein 318	Mus musculus	104-110
24616512-4	2014	A point mutation in an evolutionarily conserved lysine-rich domain encoded by the alternatively spliced Zfp318 exon 10 abolished IgD expression on marginal zone B cells, decreased IgD on follicular B cells, and increased IgM, but only slightly decreased the percentage of B cells and did not decrease expression of other maturation markers CD21, CD23, or CD62L.	Lysine	48-54	complement receptor 2	Mus musculus	340-344
24492612-2	2014	Lysine 142 of DNMT1 is methylated by the SET domain containing lysine methyltransferase 7 (SET7), leading to its degradation by proteasome.	Lysine	0-6	DNA methyltransferase 1	Homo sapiens	14-19
24443563-7	2014	Mutation of five lysine residues in this region significantly stabilizes MutYH, suggesting that these are the target sites for ubiquitination.	Lysine	17-23	mutY DNA glycosylase	Homo sapiens	73-78
10688489-0	2000	Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer.	Lysine	30-33	immunoglobulin kappa variable 1-13	Homo sapiens	35-38
10688489-8	2000	These results suggest MDP-Lys (L18) instilled by intrapleural route had a potential local immunomodulatory activity.	Lysine	26-29	immunoglobulin kappa variable 1-13	Homo sapiens	31-34
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Lysine	165-171	carboxypeptidase B2 (plasma)	Mus musculus	20-23
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Lysine	165-171	carboxypeptidase B2 (plasma)	Mus musculus	106-109
15555906-5	2004	When the arginines were replaced by lysines, the sensitivity to cytochrome b(5) was restored and the acyl-carbon cleavage activities were recovered.	Lysine	36-43	cytochrome b5 type A	Homo sapiens	64-79
11012092-7	2000	The increase in Bmax was correlated with plasmin-mediated exposure of C-terminal lysines since treatment of plasmin-modified fibrinogen surfaces with carboxypeptidase B produced a significant decrease in total binding signal as detected by ELISA (enzyme linked immunosorbent assay).	Lysine	81-88	carboxypeptidase B1	Homo sapiens	150-168
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Lysine	142-148	arginine permease CAN1	Saccharomyces cerevisiae S288C	87-91
24448798-7	2014	We show that the single substitution T456S results in a Can1 variant transporting lysine in addition to arginine and that the combined substitutions T456S and S176N convert Can1 to a Lyp1-like permease.	Lysine	82-88	arginine permease CAN1	Saccharomyces cerevisiae S288C	56-60
24448798-9	2014	Measurements of the kinetic parameters of arginine and lysine uptake by the wild-type and mutant Can1 permeases, together with docking calculations for each amino acid in their binding site, suggest a model in which residues at positions 176 and 456 confer substrate selectivity at the ligand-binding stage and/or in the course of conformational changes required for transport.	Lysine	55-61	arginine permease CAN1	Saccharomyces cerevisiae S288C	97-101
11206575-5	2000	An in vitro DNA binding experiment with mutants CreK244R and CreK244L revealed that lysine 244 of Cre plays an important role in interaction with the engineered lox.	Lysine	84-90	lysyl oxidase	Homo sapiens	161-164
15367628-4	2004	If transient ubiquitination of RSV Gag is required for budding, then replacement of the target lysine(s) with arginine should prevent the addition of Ub and reduce budding.	Lysine	95-101	Pr76 polyprotein precursor	Rous sarcoma virus	35-38
24415758-4	2014	Using LC-MS/MS-based proteomic analysis, this study revealed AF-1 monomethylation at Lys-464.	Lysine	85-88	interferon gamma receptor 2	Homo sapiens	61-65
24415758-10	2014	These results suggest that monomethylation of PR at Lys-464 probably has a repressive effect on AF-1 activity and ligand sensitivity.	Lysine	52-55	interferon gamma receptor 2	Homo sapiens	96-100
15350136-8	2004	For example, both increased levels of acetylation and a previously unidentified dimethylation of both lysine and arginine residues were found on HMGA1a proteins from metastatic cells compared to proteins found in their nonmetastatic precursors.	Lysine	102-108	high mobility group AT-hook 1	Homo sapiens	145-151
24586832-6	2014	In a preliminary analysis we identify lysine 91, a residue known to be critical for formation and DNA binding of the VDR-RXR heterodimer, as a minor SUMO acceptor site within VDR.	Lysine	38-44	vitamin D receptor	Homo sapiens	117-120
24586832-6	2014	In a preliminary analysis we identify lysine 91, a residue known to be critical for formation and DNA binding of the VDR-RXR heterodimer, as a minor SUMO acceptor site within VDR.	Lysine	38-44	retinoid X receptor alpha	Homo sapiens	121-124
11315093-7	2000	Significant activation of FAK was demonstrated when cells adhered to fibronectin, as compared to poly-L-lysine, thus demonstrating that beta-1-integrin plays a significant role in activating FAK.	Lysine	97-110	integrin subunit beta 1	Homo sapiens	136-151
10992159-1	2000	We examined the formation of quaternary pyridinium crosslinks of elastin formed by condensation of lysine and allysine residues using the model compounds propanal (allysine) and n-butylamine (lysine) under quasi-physiological conditions.	Lysine	99-105	elastin	Homo sapiens	65-72
24586832-6	2014	In a preliminary analysis we identify lysine 91, a residue known to be critical for formation and DNA binding of the VDR-RXR heterodimer, as a minor SUMO acceptor site within VDR.	Lysine	38-44	vitamin D receptor	Homo sapiens	175-178
10992159-1	2000	We examined the formation of quaternary pyridinium crosslinks of elastin formed by condensation of lysine and allysine residues using the model compounds propanal (allysine) and n-butylamine (lysine) under quasi-physiological conditions.	Lysine	112-118	elastin	Homo sapiens	65-72
15297880-4	2004	In this study, we demonstrate that interaction of the human SRY with histone acetyltransferase p300 induces the acetylation of SRY both in vitro and in vivo at a single conserved lysine residue.	Lysine	179-185	sex determining region Y	Homo sapiens	60-63
10587460-7	1999	Therefore, the boundary for the minimal DNA-binding domain in hVDR extends C-terminal of the zinc fingers to Lys-111, with clusters of highly conserved charged amino acids playing a crucial role in binding to the DR+3 element.	Lysine	109-112	vitamin D receptor	Homo sapiens	62-66
24757500-0	2014	Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.	Lysine	78-84	lysine demethylase 1A	Homo sapiens	41-45
15297880-4	2004	In this study, we demonstrate that interaction of the human SRY with histone acetyltransferase p300 induces the acetylation of SRY both in vitro and in vivo at a single conserved lysine residue.	Lysine	179-185	sex determining region Y	Homo sapiens	127-130
15178693-3	2004	Here we identify two basic amino acid residues within the L-selectin tail that are required for binding to ezrin-radixinmoesin (ERM) proteins: arginine 357 and lysine 362.	Lysine	160-166	selectin L	Homo sapiens	58-68
24338848-2	2014	These modifiers are reversibly attached via an isopeptide bond to lysine side chains of their target proteins by the action of specific E1, E2, and E3 enzymes.	Lysine	66-72	cystatin 12, pseudogene	Homo sapiens	140-150
23872426-8	2014	Significant decrease of GFAP+ cells was detected among cells growing on poly-l-lysine, while on fibronectin and vitronectin, this effect was observed only in the highest (1muM) concentration of MeHgCl.	Lysine	72-85	glial fibrillary acidic protein	Homo sapiens	24-28
10563822-2	1999	The helical positions of glutamine-84, tyrosine-63, and lysine-87 are suggested to correspond to E7, B10, and E10, respectively, in the distal heme pocket on the basis of amino acid sequence comparison of mammalian globins.	Lysine	56-62	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	101-104
10586911-3	1999	Recently, a mutation in the coding region of ICAM-1, termed ICAM-1Kilifi, was described, causing a change from Lys to Met in the loop that interacts with rhinoviruses, lymphocytes, and parasitized red blood cells.	Lysine	111-114	intercellular adhesion molecule 1	Homo sapiens	45-51
15180994-4	2004	Methylation of lysine 4 of H3 via Set1, a component of the Saccharomyces cerevisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquitination Rad6-Bre1 complexes, which are required for the expression of a subset of genes.	Lysine	15-21	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	34-38
15180994-4	2004	Methylation of lysine 4 of H3 via Set1, a component of the Saccharomyces cerevisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquitination Rad6-Bre1 complexes, which are required for the expression of a subset of genes.	Lysine	15-21	Rtf1p	Saccharomyces cerevisiae S288C	153-157
15180994-4	2004	Methylation of lysine 4 of H3 via Set1, a component of the Saccharomyces cerevisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquitination Rad6-Bre1 complexes, which are required for the expression of a subset of genes.	Lysine	15-21	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	185-189
15180994-6	2004	We show here that H3 lysine 4 methylation also negatively regulated gene expression, as strains without Set1 showed enhanced expression of PHO5, wherein chromatin structure plays an important transcriptional regulatory role.	Lysine	21-27	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	104-108
15166213-3	2004	The lysine and leucine biosynthetic pathways each contain a 4Fe-4S cluster enzyme homologous to aconitase and likely to be superoxide-sensitive, homoaconitase (Lys4p) and isopropylmalate dehydratase (Leu1p), respectively.	Lysine	4-10	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	160-165
10632938-6	1999	In the other, we observed a novel mutation at nucleotide position 571, which changes codon 169 lysine (AAG) into the amber stop codon (TAG) (K169X).	Lysine	95-101	N-methylpurine DNA glycosylase	Homo sapiens	103-106
24489825-3	2014	Physiological endocytic itinerary of agonist occupied CXCR4 involves ubiquitinylation of the phosphorylated receptor at three critical lysine residues and dynamin-dependent trafficking through the ESCRT pathway into lysosomes for degradation.	Lysine	135-141	C-X-C motif chemokine receptor 4	Homo sapiens	54-59
24489825-4	2014	Likewise, Nef induced CXCR4 degradation was critically dependent on the three lysines in the C-terminal -SSLKILSKGK- motif.	Lysine	78-85	C-X-C motif chemokine receptor 4	Homo sapiens	22-27
15166213-9	2004	Thus, we conclude that when Sod1p is absent a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originates in the intermembrane space and diffuses across the inner membrane.	Lysine	46-52	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	83-88
15132984-0	2004	Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer"s neurofibrillary tangles.	Lysine	89-95	heat shock protein family B (small) member 1	Homo sapiens	28-33
24388984-0	2014	Critical lysine residues of Klf4 required for protein stabilization and degradation.	Lysine	9-15	Kruppel like factor 4	Homo sapiens	28-32
24388984-2	2014	As the ubiquitination and degradation of the Klf4 protein have been suggested to play an important role in its function, the identification of specific lysine sites that are responsible for protein degradation is of prime interest to improve protein stability and function.	Lysine	152-158	Kruppel like factor 4	Homo sapiens	45-49
24388984-4	2014	In this study, both the analysis of Klf4 ubiquitination sites using several Klf4 deletion fragments and bioinformatics predictions showed that the lysine sites which are signaling for Klf4 protein degradation lie in its N-terminal domain (aa 1-296).	Lysine	147-153	Kruppel like factor 4	Homo sapiens	36-40
24388984-4	2014	In this study, both the analysis of Klf4 ubiquitination sites using several Klf4 deletion fragments and bioinformatics predictions showed that the lysine sites which are signaling for Klf4 protein degradation lie in its N-terminal domain (aa 1-296).	Lysine	147-153	Kruppel like factor 4	Homo sapiens	76-80
24388984-4	2014	In this study, both the analysis of Klf4 ubiquitination sites using several Klf4 deletion fragments and bioinformatics predictions showed that the lysine sites which are signaling for Klf4 protein degradation lie in its N-terminal domain (aa 1-296).	Lysine	147-153	Kruppel like factor 4	Homo sapiens	76-80
24388984-6	2014	These results suggest that Klf4 undergoes proteasomal degradation and that these lysine residues are critical for Klf4 ubiquitination.	Lysine	81-87	Kruppel like factor 4	Homo sapiens	27-31
24388984-6	2014	These results suggest that Klf4 undergoes proteasomal degradation and that these lysine residues are critical for Klf4 ubiquitination.	Lysine	81-87	Kruppel like factor 4	Homo sapiens	114-118
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Lysine	117-123	lipoprotein lipase	Mus musculus	136-139
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Lysine	117-123	lipoprotein lipase	Mus musculus	190-193
15132984-0	2004	Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer"s neurofibrillary tangles.	Lysine	89-95	synuclein alpha	Homo sapiens	47-62
10514459-5	1999	Within the 5-lipoxygenase protein is a sequence (Arg(638)-Lys(655)) that closely resembles a bipartite nuclear localization signal.	Lysine	58-61	arachidonate 5-lipoxygenase	Mus musculus	11-25
24416163-5	2014	Mechanistically, this gene silencing may be due to Polycomb complex mediated repression via methylation of histone H3 lysine 27.	Lysine	118-124	chromobox 2	Mus musculus	51-59
15132984-8	2004	One lysine residue of parkin and one of alpha-synuclein were also found to be cross-linked.	Lysine	4-10	synuclein alpha	Homo sapiens	40-55
15242606-3	2004	A lysine residue (Lys-233) is found in the active site emanating from strand beta2 rather than strand beta3 as in other protein kinases.	Lysine	2-8	neuronal differentiation 1	Homo sapiens	77-82
24409311-6	2014	Transcriptional up- and down-regulation accompany an increase in acetylation levels of histone H3 lysine 9 at the promoter regions of Abcb1b and Abcb1a, respectively.	Lysine	98-104	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	134-140
10400884-5	1999	HyA strands were crosslinked by glutaraldehyde and then resurfaced with poly-D-lysine, poly-L-lysine, glycine, or glutamine.	Lysine	87-100	lysine demethylase 5D	Homo sapiens	0-3
24967351-7	2014	In the gonadal adipose tissues, combinations of DHA and lysine inhibited mRNA expression of lipid metabolism-associated genes, including ACC1, fatty acid synthase, lipoprotein lipase, and perilipin.	Lysine	56-62	lipoprotein lipase	Mus musculus	164-182
15242606-3	2004	A lysine residue (Lys-233) is found in the active site emanating from strand beta2 rather than strand beta3 as in other protein kinases.	Lysine	2-8	basic helix-loop-helix family member e22	Homo sapiens	102-107
15242606-3	2004	A lysine residue (Lys-233) is found in the active site emanating from strand beta2 rather than strand beta3 as in other protein kinases.	Lysine	18-21	neuronal differentiation 1	Homo sapiens	77-82
10521527-0	1999	The role of opaque2 in the control of lysine-degrading activities in developing maize endosperm.	Lysine	38-44	regulatory protein opaque-2	Zea mays	12-19
10521527-7	1999	These results suggest that lysine levels in the endosperm are likely to be controlled at the transcriptional level by the Opaque2 transcription factor.	Lysine	27-33	regulatory protein opaque-2	Zea mays	122-129
15242606-3	2004	A lysine residue (Lys-233) is found in the active site emanating from strand beta2 rather than strand beta3 as in other protein kinases.	Lysine	18-21	basic helix-loop-helix family member e22	Homo sapiens	102-107
15140974-3	2004	We recently identified lysine 234 (rK234) in mATRC1 as a residue that influences virus binding and infection.	Lysine	23-29	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	45-51
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Lysine	127-130	zona pellucida glycoprotein 3	Mus musculus	77-81
25229858-0	2014	Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1  mutant.	Lysine	22-28	cationic amino acid transporter	Saccharomyces cerevisiae S288C	98-102
24553073-2	2014	Recently we reported that JmjC demethylase KDM2A reduces rDNA transcription on starvation, with accompanying demethylation of dimethylated Lys 36 of histone H3 (H3K36me2) in rDNA promoter.	Lysine	139-142	lysine demethylase 2A	Homo sapiens	43-48
15007390-7	2004	Furthermore, loss of CpG methylation was associated with loss of histone H3 lysine 9 (H3K9) methylation at DMR-LIT1.	Lysine	76-82	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	111-115
25182761-4	2014	Transcription of estrogen-responsive genes is triggered by the lysine-specific demethylase 1 (LSD1)-dependent demethylation of dimethylated lysine 9 in histone H3 (H3K9me2) that accompanies to local generation of oxygen reactive species (ROS).	Lysine	63-69	lysine demethylase 1A	Homo sapiens	94-98
10412040-4	1999	This inhibition was attributed to the formation of Schiff bases between "reactive aldehydes" and lysine residues of the DNA binding domain (DBD) of the VDR, but point mutagenesis data of different lysine residues in this study could not confirm this idea.	Lysine	97-103	vitamin D receptor	Homo sapiens	152-155
10412040-4	1999	This inhibition was attributed to the formation of Schiff bases between "reactive aldehydes" and lysine residues of the DNA binding domain (DBD) of the VDR, but point mutagenesis data of different lysine residues in this study could not confirm this idea.	Lysine	197-203	vitamin D receptor	Homo sapiens	152-155
15110758-4	2004	FAST is tethered to mitochondria by a lysine/arginine-rich domain at its carboxyl terminus that is structurally similar to the mitochondrial tethering motifs of monoamine oxidase B and cytochrome b5.	Lysine	38-44	cytochrome b5 type A	Homo sapiens	185-198
10446374-6	1999	Reversible substitution of lysine residues with citraconic anhydride led to increased solubility of the recombinant TPO, allowing high-yield purification by monoclonal antibody chromatography.	Lysine	27-33	thyroid peroxidase	Homo sapiens	116-119
24214985-0	2013	Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.	Lysine	22-28	lysine demethylase 3A	Homo sapiens	98-126
24214985-0	2013	Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.	Lysine	22-28	lysine demethylase 3A	Homo sapiens	128-134
24247240-6	2013	This mechanism of Ras activation is distinct from K-Ras monoubiquitination at Lys-147, which leads to impaired regulator-mediated GTP hydrolysis.	Lysine	78-81	KRAS proto-oncogene, GTPase	Homo sapiens	50-55
15110905-1	2004	BACKGROUND: Mutations in serine-threonine kinase WNK4 with no lysine (K) at a key catalytic residue cause familial hypertension known as pseudohypoaldosteronism type II (PHAII).	Lysine	62-68	WNK lysine deficient protein kinase 4	Homo sapiens	49-53
24247247-0	2013	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.	Lysine	89-95	protein arginine methyltransferase 7	Homo sapiens	10-46
24247247-0	2013	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.	Lysine	89-95	protein arginine methyltransferase 7	Homo sapiens	48-53
24247247-0	2013	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.	Lysine	89-95	retinoid X receptor alpha	Homo sapiens	76-79
24247247-6	2013	Analysis of the specific methylation sites within intact histone H2B and within H2B and H4 peptides revealed novel post-translational modification sites and a unique specificity of PRMT7 for methylating arginine residues in lysine- and arginine-rich regions.	Lysine	224-230	protein arginine methyltransferase 7	Homo sapiens	181-186
10428809-6	1999	The functional consequence of up-regulating the lysine binding property of K2(Pg) was explored, as reflected by its ability to interact with an internal sequence of a plasminogen-binding protein (PAM) on the surface of group A streptococci.	Lysine	48-54	RBPJ pseudogene 3	Homo sapiens	75-81
10428809-6	1999	The functional consequence of up-regulating the lysine binding property of K2(Pg) was explored, as reflected by its ability to interact with an internal sequence of a plasminogen-binding protein (PAM) on the surface of group A streptococci.	Lysine	48-54	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	196-199
10428809-11	1999	Results of these PAM peptide binding studies parallel results of omega-amino acid binding to these K2(Pg) mutants, indicating that the high affinity PAM binding by plasminogen, mediated exclusively through K2(Pg), occurs through its lysine-binding site.	Lysine	233-239	RBPJ pseudogene 3	Homo sapiens	99-105
10428809-11	1999	Results of these PAM peptide binding studies parallel results of omega-amino acid binding to these K2(Pg) mutants, indicating that the high affinity PAM binding by plasminogen, mediated exclusively through K2(Pg), occurs through its lysine-binding site.	Lysine	233-239	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	149-152
10428809-11	1999	Results of these PAM peptide binding studies parallel results of omega-amino acid binding to these K2(Pg) mutants, indicating that the high affinity PAM binding by plasminogen, mediated exclusively through K2(Pg), occurs through its lysine-binding site.	Lysine	233-239	RBPJ pseudogene 3	Homo sapiens	206-212
15105826-1	2004	Histone H3 lysine 9 methylation is associated with long-term transcriptional repression through recruitment of heterochromatin protein 1 (HP1) proteins.	Lysine	11-17	chromobox 5	Homo sapiens	111-136
10449136-3	1999	Sequencing revealed G to A transition in the codon 54 causing TTR Lys 54.	Lysine	66-69	transthyretin	Homo sapiens	62-65
10456318-5	1999	CaMKPase was not significantly phosphorylated by CaMKII under the standard phosphorylation conditions but was phosphorylated in the presence of poly-L-lysine, which is a potent activator of CaMKPase.	Lysine	144-157	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	0-8
10456318-5	1999	CaMKPase was not significantly phosphorylated by CaMKII under the standard phosphorylation conditions but was phosphorylated in the presence of poly-L-lysine, which is a potent activator of CaMKPase.	Lysine	144-157	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	190-198
24327761-6	2013	Additional subunits of the PRC2 complex, including the catalytic subunit EZH2, were then recruited in a JARID2-dependent manner that was concurrent with the loss of RNAPII and the methylation of Lys(27) of histone H3 (H3K27), which is associated with gene repression.	Lysine	195-198	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	73-77
24327761-6	2013	Additional subunits of the PRC2 complex, including the catalytic subunit EZH2, were then recruited in a JARID2-dependent manner that was concurrent with the loss of RNAPII and the methylation of Lys(27) of histone H3 (H3K27), which is associated with gene repression.	Lysine	195-198	jumonji, AT rich interactive domain 2	Mus musculus	104-110
24312501-6	2013	Further analysis indicates six heavily acetylated lysine residues at positions 89, 153, 189, 218, 259 and 331 of GFAP.	Lysine	50-56	glial fibrillary acidic protein	Homo sapiens	113-117
15105826-1	2004	Histone H3 lysine 9 methylation is associated with long-term transcriptional repression through recruitment of heterochromatin protein 1 (HP1) proteins.	Lysine	11-17	chromobox 5	Homo sapiens	138-141
10435998-11	1999	The net effect of increasing open state stability, either by PIP(2) or mutagenesis, is an apparent "uncoupling" of the Kir6.2 subunit from the regulatory input of SUR1, an action that can be partially reversed by screening negative charges on the membrane with poly-L-lysine.	Lysine	261-274	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	119-125
15105826-6	2004	Dissociation of HP1 from the methylated histone H3 tails is observed only after a third modification by acetylation of lysine 14, which occurs in prophase.	Lysine	119-125	chromobox 5	Homo sapiens	16-19
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Lysine	150-156	carboxypeptidase B2 (plasma)	Mus musculus	0-43
10381591-18	1999	In addition, SIN-1 and LY 83583 exert cyclic GMP-independent positive inotropic effects, which require the generation of superoxide anion.	Lysine	23-25	5'-nucleotidase, cytosolic II	Homo sapiens	45-48
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Lysine	150-156	carboxypeptidase B2 (plasma)	Mus musculus	45-49
24115035-8	2013	Moreover, the augmented association of p52/acetylation of histone H3 at lysine 56 with the promoter of ubiquitin E3 ligase, S-phase kinase-associated protein 2, was shown in AMPKalpha2(-/-) VSMCs by chromatin immunoprecipitation assay.	Lysine	72-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	39-42
15066435-1	2004	Dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52) catalyses the branchpoint reaction of lysine biosynthesis in plants and microbes: the condensation of (S)-aspartate-beta-semialdehyde and pyruvate.	Lysine	88-94	dihydrodipicolinate synthase	Escherichia coli	0-28
23871831-7	2013	FBXL19 bound the small GTPase in the cytoplasm leading to RhoA ubiquitination at Lys(135).	Lysine	81-84	F-box and leucine rich repeat protein 19	Homo sapiens	0-6
24219278-1	2013	The Jumonji D2 proteins (JMJD2/KDM4) function to demethylate di- and trimethylated (me2/3) histone 3 lysine 9 (H3K9me2/3) and H3K36me3.	Lysine	101-107	lysine (K)-specific demethylase 4A	Mus musculus	25-30
10331950-4	1999	In addition, we have identified a novel motif, Lys-X-X-Leu/Ile-X-X-Leu/Ile (KIL motif), that is located shortly upstream of a subset of RING-H2 proteins, including RNF6.	Lysine	47-50	ring finger protein 6	Rattus norvegicus	164-168
10492011-5	1999	BCNs also interact in a substrate-dependent way with GFs: BDNF treatment leads to a reduction of outgrowth on poly-L-lysine but an enhancement on fibronectin and laminin.	Lysine	110-123	brain derived neurotrophic factor	Homo sapiens	58-62
15066435-1	2004	Dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52) catalyses the branchpoint reaction of lysine biosynthesis in plants and microbes: the condensation of (S)-aspartate-beta-semialdehyde and pyruvate.	Lysine	88-94	dihydrodipicolinate synthase	Escherichia coli	30-35
15049703-4	2004	As predicted by the structure data, we identify a Cys(35)-containing proteolytic fragment (Tyr(25)-Lys(111)) from cytochrome b(6) as a peptide that covalently binds a heme.	Lysine	99-102	cytochrome b	Chlamydomonas reinhardtii	114-126
10361278-5	1999	Mutation of the Ino80p lysine residue corresponding to the NTP binding site of Snf2p led to a non-functional protein.	Lysine	23-29	SWI/SNF catalytic subunit SNF2	Saccharomyces cerevisiae S288C	79-84
24036897-3	2013	Here, we demonstrate that antioxidant protein 1 (Atox1 in human cells), the principal cellular copper chaperone responsible for delivery of copper to the secretory pathway, possesses the ability to interact with negatively charged lipid headgroups via distinct surface lysine residues.	Lysine	269-275	peroxiredoxin 3	Homo sapiens	26-47
24036897-3	2013	Here, we demonstrate that antioxidant protein 1 (Atox1 in human cells), the principal cellular copper chaperone responsible for delivery of copper to the secretory pathway, possesses the ability to interact with negatively charged lipid headgroups via distinct surface lysine residues.	Lysine	269-275	antioxidant 1 copper chaperone	Homo sapiens	49-54
24106274-4	2013	Here, we report that ubiquitination of the DUB ataxin-3 at lysine residue 117, which markedly enhances its protease activity in vitro, is critical for its ability to suppress toxic protein-dependent degeneration in Drosophila melanogaster.	Lysine	59-65	subito	Drosophila melanogaster	43-46
24121505-5	2013	Surprisingly, a single lysine residue within the intracellular domain rescues shedding of Tim-3.	Lysine	23-29	hepatitis A virus cellular receptor 2	Homo sapiens	90-95
15194235-3	2004	It has been shown that DHDPS is partially feedback inhibited by (S)-lysine; it is suggested that this mechanism regulates flux through the DAP biosynthetic pathway.	Lysine	64-74	dihydrodipicolinate synthase	Escherichia coli	23-28
10216163-0	1999	The Saccharomyces cerevisiae succinate dehydrogenase anchor subunit, Sdh4p: mutations at the C-terminal lys-132 perturb the hydrophobic domain.	Lysine	104-107	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	69-74
10216163-3	1999	We identify Lys-132 in the Sdh4p C-terminal region as necessary for enzyme stability, ubiquinone reduction, and cytochrome b562 assembly in SDH.	Lysine	12-15	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	27-32
10216163-4	1999	Five Lys-132 substituted SDH4 genes were constructed by site-directed mutagenesis and introduced into an SDH4 knockout strain.	Lysine	5-8	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	105-109
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	chemokine (C-C motif) ligand 2	Mus musculus	206-240
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	chemokine (C-C motif) ligand 2	Mus musculus	241-246
10198256-7	1999	This multiprotein complex exhibits a kinase activity with a requirement for lysine 821 in the BUB1 kinase motif, resulting in BUB1 autophosphorylation and phosphorylation of associated MAD1.	Lysine	76-82	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	94-98
10198256-7	1999	This multiprotein complex exhibits a kinase activity with a requirement for lysine 821 in the BUB1 kinase motif, resulting in BUB1 autophosphorylation and phosphorylation of associated MAD1.	Lysine	76-82	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	126-130
15194235-4	2004	Others have characterised DHDPS from Escherichia coli with respect to (S)-lysine inhibition.	Lysine	70-80	dihydrodipicolinate synthase	Escherichia coli	26-31
15194235-5	2004	They have concluded that, with respect to pyruvate, the first substrate of the reaction, DHDPS shows uncompetitive inhibition: as such, they further suggest that (S)-lysine inhibits DHDPS via interaction with the binding site for the second substrate, (S)-ASA.	Lysine	162-172	dihydrodipicolinate synthase	Escherichia coli	89-94
15194235-5	2004	They have concluded that, with respect to pyruvate, the first substrate of the reaction, DHDPS shows uncompetitive inhibition: as such, they further suggest that (S)-lysine inhibits DHDPS via interaction with the binding site for the second substrate, (S)-ASA.	Lysine	162-172	dihydrodipicolinate synthase	Escherichia coli	182-187
10103047-6	1999	Mutations, LYS20fbr and LYS21fbr, are allelic to LYS20 and LYS21, and lead to desensitization of homocitrate synthase activity towards lysine and to a loss of apparent repression by this amino acid.	Lysine	135-141	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	11-16
15194235-7	2004	In light of crystallographic studies, which lead to the proposal that (S)-lysine affects the putative proton-relay of DHDPS, we re-evaluated the inhibition mechanism of DHDPS with respect to (S)-lysine by incorporating the observed hyperbolic inhibition.	Lysine	70-80	dihydrodipicolinate synthase	Escherichia coli	118-123
10103047-6	1999	Mutations, LYS20fbr and LYS21fbr, are allelic to LYS20 and LYS21, and lead to desensitization of homocitrate synthase activity towards lysine and to a loss of apparent repression by this amino acid.	Lysine	135-141	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	49-54
10103047-6	1999	Mutations, LYS20fbr and LYS21fbr, are allelic to LYS20 and LYS21, and lead to desensitization of homocitrate synthase activity towards lysine and to a loss of apparent repression by this amino acid.	Lysine	135-141	homocitrate synthase LYS21	Saccharomyces cerevisiae S288C	24-29
24207024-3	2013	Acetylation of PAF53 at lysine 373 by CBP and deacetylation by SIRT7 modulate the association of Pol I with DNA, hypoacetylation correlating with increased rDNA occupancy of Pol I and transcription activation.	Lysine	24-30	RNA polymerase I subunit E	Homo sapiens	15-20
15194235-7	2004	In light of crystallographic studies, which lead to the proposal that (S)-lysine affects the putative proton-relay of DHDPS, we re-evaluated the inhibition mechanism of DHDPS with respect to (S)-lysine by incorporating the observed hyperbolic inhibition.	Lysine	70-80	dihydrodipicolinate synthase	Escherichia coli	169-174
24207025-5	2013	Mutation of lysines or p300 inhibitor treatment causes the loss of epidermal growth-factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused polymerases, but does not affect expression or polymerase occupancy at housekeeping genes.	Lysine	12-19	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
15194235-7	2004	In light of crystallographic studies, which lead to the proposal that (S)-lysine affects the putative proton-relay of DHDPS, we re-evaluated the inhibition mechanism of DHDPS with respect to (S)-lysine by incorporating the observed hyperbolic inhibition.	Lysine	191-201	dihydrodipicolinate synthase	Escherichia coli	169-174
10077471-2	1999	Lys-15 of BPTI was protected by trypsin bound to BPTI, then O-methylisourea (OMIU) was used to guanidinate all unprotected lysines.	Lysine	0-3	spleen trypsin inhibitor I	Bos taurus	10-14
15194235-9	2004	Thus, consistent with the crystallographic data, (S)-lysine must have an effect on the initial steps of the DHDPS reaction, including the binding of pyruvate and Schiff base formation.	Lysine	49-59	dihydrodipicolinate synthase	Escherichia coli	108-113
10077471-2	1999	Lys-15 of BPTI was protected by trypsin bound to BPTI, then O-methylisourea (OMIU) was used to guanidinate all unprotected lysines.	Lysine	0-3	spleen trypsin inhibitor I	Bos taurus	49-53
10077471-2	1999	Lys-15 of BPTI was protected by trypsin bound to BPTI, then O-methylisourea (OMIU) was used to guanidinate all unprotected lysines.	Lysine	123-130	spleen trypsin inhibitor I	Bos taurus	10-14
23756451-12	2013	Overall, acetylated histone H3 at lysine 9 was increased in spinal cord tissues after incision, and enhanced association of acetylated histone H3 at lysine 9 with the promoter regions of CXCR2 and keratinocyte-derived chemokine (CXCL1) was observed as well.	Lysine	149-155	chemokine (C-X-C motif) receptor 2	Mus musculus	187-192
15060161-2	2004	In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.	Lysine	94-100	catenin beta 1	Homo sapiens	78-90
23711388-2	2013	JMJD3 is a histone-3 lysine-27 trimethylation (H3K27me3) demethylase, a histone mark associated with transcriptional repression and activation of a diverse set of genes.	Lysine	21-27	lysine demethylase 6B	Homo sapiens	0-5
9933646-9	1999	Nonetheless, a subtle role in TIMP-2 interaction for the 566/567/568-lysine triad is indicated from the enhanced reduction in TIMP-2 binding that occurs when mutations here were combined with K617A.	Lysine	69-75	TIMP metallopeptidase inhibitor 2	Homo sapiens	30-36
15059001-3	2004	A myoglobin variant was formed by reaction of the lysine epsilon-amino group with succinic anhydride.	Lysine	50-56	myoglobin	Homo sapiens	2-11
9882312-2	1999	The F13L protein contains a variant of the HKD (His-Lys-Asp) motif, which is conserved in numerous enzymes of phospholipid metabolism.	Lysine	52-55	palmytilated EEV membrane glycoprotein	Vaccinia virus	4-8
23890588-12	2013	Mutational screening of the AASS gene revealed that case 1 was a compound heterozygote for c.2662 + 1_2662 + 5delGTAAGinsTT and c.874A&gt;G and that case 2 was a compound heterozygote for c.976_977delCA and c.1925C&gt;G. In conclusion, we present two children with hyperlysinemia type I and neurological impairment in which implementation of lysine-restricted diet achieved a mild improvement of symptoms but did not reverse cognitive impairment.	Lysine	270-276	aminoadipate-semialdehyde synthase	Homo sapiens	28-32
14993285-1	2004	Methylation of histone H3 at lysine 9 (H3-K9) mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites.	Lysine	29-35	chromobox 5	Mus musculus	111-114
24244184-6	2013	In this study, furthermore, we have focused on promoters containing the nuclear respiratory factor 1 (NRF1) motif as the cardinal cis-regulatory element and have identified the pervasive association of NRF1 with the cofactor lysine-specific demethylase 1 (LSD1/KDM1A).	Lysine	225-231	lysine demethylase 1A	Homo sapiens	256-260
24244184-6	2013	In this study, furthermore, we have focused on promoters containing the nuclear respiratory factor 1 (NRF1) motif as the cardinal cis-regulatory element and have identified the pervasive association of NRF1 with the cofactor lysine-specific demethylase 1 (LSD1/KDM1A).	Lysine	225-231	lysine demethylase 1A	Homo sapiens	261-266
24165091-1	2013	BACKGROUND: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	12-41
10208646-7	1999	The codon 143 polymorphism appears to be linked to another new polymorphic alteration at codon 178, which converts lysine (AAG) to arginine (AGG).	Lysine	115-121	N-methylpurine DNA glycosylase	Homo sapiens	123-126
9890950-7	1999	Similarly, Cak1p is insensitive to the ATP analog 5"-fluorosulfonylbenzoyladenosine, which inhibits most protein kinases through covalent modification of the invariant lysine.	Lysine	168-174	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	11-16
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Lysine	180-183	general transcription factor IIA subunit 2	Homo sapiens	133-138
9890950-9	1999	Remarkably, Cak1p remains functional even following truncation of its first 31 amino acids, including the glycine loop region and the invariant lysine.	Lysine	144-150	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	12-17
24165091-1	2013	BACKGROUND: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	43-47
24165091-1	2013	BACKGROUND: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	63-68
10052689-4	1999	The C-terminal of the mCKs was concluded to be a lysine residue because the mCKs treated with carboxypeptidase B migrated to positions closer to the anode than did those not treated with carboxypeptidase B.	Lysine	49-55	carboxypeptidase B1	Homo sapiens	94-112
24165091-1	2013	BACKGROUND: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription.	Lysine	162-168	lysine demethylase 1A	Homo sapiens	73-77
14747703-0	2004	The impact of Lys--&gt;Arg surface mutations on the crystallization of the globular domain of RhoGDI.	Lysine	14-17	Rho GDP dissociation inhibitor alpha	Homo sapiens	94-100
23974797-8	2013	Beclin 1 is ubiquitinated at lysine 437 through lysine 63 linkage in cells undergoing autophagy.	Lysine	29-35	beclin 1	Homo sapiens	0-8
10052689-4	1999	The C-terminal of the mCKs was concluded to be a lysine residue because the mCKs treated with carboxypeptidase B migrated to positions closer to the anode than did those not treated with carboxypeptidase B.	Lysine	49-55	carboxypeptidase B1	Homo sapiens	187-205
23974797-8	2013	Beclin 1 is ubiquitinated at lysine 437 through lysine 63 linkage in cells undergoing autophagy.	Lysine	48-54	beclin 1	Homo sapiens	0-8
14572310-2	2004	Recently, a new class of histone methyltransferases that plays an indirect role in chromatin silencing by targeting a conserved lysine residue in the nucleosome core was described, namely the Dot1 (disruptor of telomeric silencing) family [Feng, Wang, Ng, Erdjument-Bromage, Tempst, Struhl and Zhang (2002) Curr.	Lysine	128-134	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	192-196
23974797-9	2013	Ambra1 is an E3 ligase for lysine 63-linked ubiquitination of Beclin 1 that is required for starvation-induced autophagy.	Lysine	27-33	beclin 1	Homo sapiens	62-70
23974797-10	2013	The lysine 437 ubiquitination of Beclin 1 enhances the association with Vps34 to promote Vps34 activity.	Lysine	4-10	beclin 1	Homo sapiens	33-41
24055926-5	2013	Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor.	Lysine	147-150	endothelin 3	Homo sapiens	45-49
10021925-1	1999	Anisylazoformyllysine (CH3OC6H4-N = N-CO-Lys-OH) is rapidly hydrolyzed at the acyl-lysine linkage by the zinc-enzyme porcine carboxypeptidase B.	Lysine	15-21	carboxypeptidase B1	Homo sapiens	125-143
9878047-6	1999	In addition, we show that GH internalization by a truncated GHR is independent of the presence of lysine residues in the cytosolic domain of this receptor, while internalization still depends on an intact ubiquitin conjugation system.	Lysine	98-104	growth hormone receptor	Homo sapiens	60-63
14580236-1	2004	DHDPS (dihydrodipicolinate synthase; EC 4.2.1.52) is the enzyme that catalyses the first unique step of lysine biosynthesis in plants and micro-organisms.	Lysine	104-110	dihydrodipicolinate synthase	Escherichia coli	7-35
10064144-6	1999	In the case of azurocidin, the phage display selection allowed determination of the P1 specificity of this protein with the following frequencies for selected P1 variants: 43% Lys, 36% Leu, 7% Met, 7% Thr, 7% Gln.	Lysine	176-179	azurocidin 1	Homo sapiens	15-25
24251111-5	2013	Here, we report on the production of milligrams of highly pure Josephin mono-ubiquitinated on lysine 117 through large scale in vitro enzymatic ubiquitination.	Lysine	94-100	ataxin 3	Homo sapiens	63-71
23974119-7	2013	Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.	Lysine	186-193	forkhead box O3	Mus musculus	99-104
15008260-3	2004	Here we describe the second report of Hb Iowa, the first in conjunction with Hb C [beta6(A3)Glu --&gt; Lys].	Lysine	103-106	keratin 88, pseudogene	Homo sapiens	77-81
24088713-3	2013	SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1.	Lysine	67-73	DNA methyltransferase 1	Homo sapiens	171-176
9878114-1	1998	CD44 contains two clustered basic residues of three arginines and three lysines in the membrane-proximal region of its cytoplasmic domain.	Lysine	72-79	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9878114-11	1998	These results provide evidence that both the arginine and the lysine motifs are important in the binding of CD44 to high levels of HA when stimulated with PMA.	Lysine	62-68	CD44 molecule (Indian blood group)	Homo sapiens	108-112
23770046-3	2013	Here we demonstrated that EVI1 is post-translationally modified by SUMO1 at lysine residues 533, 698 and 874.	Lysine	76-82	MDS1 and EVI1 complex locus	Homo sapiens	26-30
14767880-7	2004	Here, we report that the replacement of Glu(9) of GLP-1 with Lys dramatically increased resistance to DPP IV.	Lysine	61-64	dipeptidyl peptidase 4	Homo sapiens	102-108
23770285-3	2013	Here we report that Sef-S physically interacts with TAK1, induces Lys63-linked TAK1 polyubiquitination on lysine 209 and TAK1-mediated JNK and p38 activation.	Lysine	106-112	interleukin 17 receptor D	Mus musculus	20-25
23770285-6	2013	These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells.	Lysine	75-81	interleukin 17 receptor D	Mus musculus	21-26
23959799-4	2013	Our data unambiguously demonstrate that Smurf1 ubiquitinates axin through Lys 29 (K29)-linked polyubiquitin chains.	Lysine	74-77	axin 1	Mus musculus	61-65
24056301-5	2013	Specifically, ubiquitylation at Lys 47 sterically inhibits RALB binding to EXO84, while facilitating its interaction with SEC5.	Lysine	32-35	exocyst complex component 8	Homo sapiens	75-80
23906520-2	2013	CFH was isolated from human plasma by polyethylene glycol (PEG) precipitation, following three sequential chromatographic columns, which consisted of l-lysine Sepharose column, Resource Q column and Sephacryl S-300 High Resolution HiPrep 16/60 column.	Lysine	150-158	complement factor H	Homo sapiens	0-3
23928305-2	2013	The LSD1 (also known as KDM1A) histone demethylase complex modifies chromatin and represses transcription in part by catalyzing demethylation of dimethylated histone H3 lysine 4 (H3K4me2), a mark for active transcription.	Lysine	169-175	lysine demethylase 1A	Homo sapiens	4-8
23928305-2	2013	The LSD1 (also known as KDM1A) histone demethylase complex modifies chromatin and represses transcription in part by catalyzing demethylation of dimethylated histone H3 lysine 4 (H3K4me2), a mark for active transcription.	Lysine	169-175	lysine demethylase 1A	Homo sapiens	24-29
23941687-8	2013	The aromatic rings of the compounds also form cation-pi interactions with the -NH3(+) group of Lys 15 residues in hTTR.	Lysine	95-98	transthyretin	Homo sapiens	114-118
24066152-2	2013	ING3, which contains a plant homeodomain (PHD) motif that can bind to trimethylated lysine 4 on histone H3 (H3K4me3), is ubiquitously expressed in mammalian tissues and governs transcriptional regulation, cell cycle control, and apoptosis via p53-mediated transcription or the Fas/caspase-8 pathway.	Lysine	84-90	inhibitor of growth family member 3	Homo sapiens	0-4
23988016-1	2013	We report classical molecular dynamics (MD) simulations and combined quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the catalytic mechanism of the rate-determining amine oxidation step in the lysine-specific demethylase 1 (LSD1)-catalyzed demethylation of the histone tail lysine (H3K4), with flavin adenine dinucleotide (FAD) acting as cofactor.	Lysine	217-223	lysine demethylase 1A	Homo sapiens	248-252
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Lysine	115-118	X-ray repair cross complementing 1	Homo sapiens	209-214
23940367-5	2013	However, active caspases can simultaneously cleave Grim at Asp132, removing the lysine necessary for ubiquitinylation as well as any existing ubiquitin conjugates.	Lysine	80-86	grim	Drosophila melanogaster	51-55
23736051-16	2013	Modeling with 2-sloped quadratic broken-line curves showed the maximum at 0.50, 0.53, and 0.54 SID Ile:Lys for ADFI, ADG, and G:F, respectively.	Lysine	103-106	ADG	Sus scrofa	117-120
23775086-5	2013	Whereas Hpa2 acetylated histones H3 and H4 (at H3 Lys-14, H4 Lys-5, and H4 Lys-12), Hpa3 acetylated only histone H4 (at Lys-8).	Lysine	61-64	histone acetyltransferase	Saccharomyces cerevisiae S288C	8-12
23775086-5	2013	Whereas Hpa2 acetylated histones H3 and H4 (at H3 Lys-14, H4 Lys-5, and H4 Lys-12), Hpa3 acetylated only histone H4 (at Lys-8).	Lysine	61-64	histone acetyltransferase	Saccharomyces cerevisiae S288C	8-12
23775086-5	2013	Whereas Hpa2 acetylated histones H3 and H4 (at H3 Lys-14, H4 Lys-5, and H4 Lys-12), Hpa3 acetylated only histone H4 (at Lys-8).	Lysine	61-64	histone acetyltransferase	Saccharomyces cerevisiae S288C	8-12
23581279-2	2013	We discovered that Jak2 is SUMOylated on multiple lysine residues by SUMO2/3 (small ubiquitin-related modifier 2/3) chains.	Lysine	50-56	small ubiquitin like modifier 2	Homo sapiens	69-76
23581279-2	2013	We discovered that Jak2 is SUMOylated on multiple lysine residues by SUMO2/3 (small ubiquitin-related modifier 2/3) chains.	Lysine	50-56	small ubiquitin like modifier 2	Homo sapiens	78-114
23666621-5	2013	The ubiquitination of Tat1 most likely occurs at N-terminal lysines 29 and 31.	Lysine	60-67	amino acid transporter TAT1	Saccharomyces cerevisiae S288C	22-26
23666621-6	2013	Simultaneous substitution of arginine for the two lysines prevented Tat1 degradation, but substitution of either of them alone did not, indicating that the roles of lysines 29 and 31 are redundant.	Lysine	50-57	amino acid transporter TAT1	Saccharomyces cerevisiae S288C	68-72
23934123-7	2013	ChIP assays demonstrated that activation of the HGF-MET pathway resulted in increased occupancy of the MLL-ETS2 complex on MMP1 and MMP3 promoters, where MLL trimethylated histone H3 lysine 4 (H3K4), activating transcription.	Lysine	183-189	hepatocyte growth factor	Mus musculus	48-51
23648696-6	2013	Pcca(-/-)(A138T) mice have 2% of wild-type PCC activity, survive to adulthood, and have elevations in propionyl-carnitine, methylcitrate, glycine, alanine, lysine, ammonia, and markers associated with cardiomyopathy similar to those in patients with PA.	Lysine	156-162	propionyl-Coenzyme A carboxylase, alpha polypeptide	Mus musculus	0-4
23661698-8	2013	Analysis of Eph/ephrin crystal structures reveals an interaction between the ligand"s carbohydrates and two residues of EphA2: Asp-78 and Lys-136.	Lysine	138-141	EPH receptor A2	Homo sapiens	120-125
23795291-1	2013	Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation.	Lysine	23-29	lysine demethylase 1A	Homo sapiens	54-58
23795291-1	2013	Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation.	Lysine	23-29	lysine demethylase 1A	Homo sapiens	59-64
23824283-1	2013	Deficiency in DNA ligase I, encoded by CDC9 in budding yeast, leads to the accumulation of unligated Okazaki fragments and triggers PCNA ubiquitination at a non-canonical lysine residue.	Lysine	171-177	DNA ligase (ATP) CDC9	Saccharomyces cerevisiae S288C	39-43
23577621-7	2013	These findings confirm the classification of ALKBH1 as an AP lyase, identify the primary and a secondary lysine residues involved in the lyase reaction, and demonstrate that the protein forms a covalent adduct with the 5" DNA product.	Lysine	105-111	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	45-51
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	90-96	sirtuin 1	Homo sapiens	175-184
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	90-96	sirtuin 1	Homo sapiens	186-191
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	102-105	sirtuin 1	Homo sapiens	175-184
23612972-4	2013	In this study, we report for the first time that REGgamma can be acetylated mostly on its lysine 195 (Lys-195) residue by CREB binding protein (CBP), which can be reversed by sirtuin 1 (SIRT1) in mammalian cells.	Lysine	102-105	sirtuin 1	Homo sapiens	186-191
23762415-0	2013	Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.	Lysine	20-26	GLI-Kruppel family member GLI2	Mus musculus	0-4
23389291-4	2013	The cleavage sites in RXRalpha were mapped by Edman N-terminal sequencing to Gly(90) Ser(91) and Lys(118) Val(119).	Lysine	97-100	retinoid X receptor alpha	Homo sapiens	22-30
23656784-0	2013	Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.	Lysine	38-44	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	128-133
23656784-0	2013	Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34.	Lysine	82-88	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	128-133
23656784-4	2013	We investigated determinants of lysine specificity of the ubiquitin-conjugating enzyme Cdc34, toward substrate and Ub lysines.	Lysine	32-38	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	87-92
23656784-5	2013	Evaluation of the relative importance of different residues positioned -2, -1, +1 and +2 toward ubiquitination of its substrate, Sic1, on lysine 50 showed that charged residues in the -1 and -2 positions negatively impact on ubiquitination.	Lysine	138-144	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	129-133
23656784-7	2013	During polyubiquitination, Cdc34 showed a strong preference for Ub lysine 48 (K48), with lower activity towards lysine 11 (K11) and lysine 63 (K63).	Lysine	67-73	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	27-32
23656784-7	2013	During polyubiquitination, Cdc34 showed a strong preference for Ub lysine 48 (K48), with lower activity towards lysine 11 (K11) and lysine 63 (K63).	Lysine	112-118	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	27-32
23656784-10	2013	These findings provide molecular and structural insight into substrate lysine and Ub K48 specificity by Cdc34.	Lysine	71-77	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	104-109
23384557-0	2013	The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	35-39
23384557-0	2013	The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	40-45
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	35-39
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	4-10	lysine demethylase 1A	Homo sapiens	40-45
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	164-170	lysine demethylase 1A	Homo sapiens	35-39
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	164-170	lysine demethylase 1A	Homo sapiens	40-45
23384557-2	2013	The lysine specific demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone lysine methylation.	Lysine	164-170	lysine demethylase 4A	Homo sapiens	89-95
23632855-7	2013	EMF1 is required for trimethylating lysine-27 on histone 3 (H3K27me3), and ULT1 associates with ARABIDOPSIS TRITHORAX1 (ATX1) for trimethylating lysine-3 on histone 4 (H3K4me3) at flower MADS box gene loci.	Lysine	145-151	Developmental regulator, ULTRAPETALA	Arabidopsis thaliana	75-79
23416211-1	2013	The effects of a snake venom Lys-49 phospholipase A2 (PLA2) homolog named MT-II, devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2 (COX-2) and signaling pathways involved were evaluated in mouse macrophages in culture and in peritoneal cells ex vivo.	Lysine	29-32	phospholipase A2, group IB, pancreas	Mus musculus	36-52
23416211-1	2013	The effects of a snake venom Lys-49 phospholipase A2 (PLA2) homolog named MT-II, devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2 (COX-2) and signaling pathways involved were evaluated in mouse macrophages in culture and in peritoneal cells ex vivo.	Lysine	29-32	phospholipase A2, group IB, pancreas	Mus musculus	54-58
23504328-6	2013	The mutation of four lysine residues on Rta that abrogated SUMO-3 conjugation to Rta also decreases the enhancement of the ubiquitination of Rta by RNF4.	Lysine	21-27	small ubiquitin like modifier 3	Homo sapiens	59-65
23457193-3	2013	In vivo, Rtt109 requires both chaperones for histone H3 lysine 9 acetylation (H3K9ac) but only Asf1 for full H3K56ac.	Lysine	56-62	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	9-15
23457193-9	2013	In addition, we show that lysine 290 (K290) in Rtt109 is required in vivo for Vps75 to enhance the activity of the HAT.	Lysine	26-32	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	47-53
23637190-4	2013	We found that excitotoxic stimulation of N-methyl-d-aspartate (NMDA) resulted in PTEN nuclear translocation in cultured neurons, a process requiring mono-ubiquitination at the lysine 13 residue (K13), as the translocation was prevented by mutation of K13 or a short interfering peptide (Tat-K13) that flanks the K13 residue.	Lysine	176-182	phosphatase and tensin homolog	Rattus norvegicus	81-85
23456478-5	2013	ApoA-I Helsinki (or  K107) is a natural apoA-I variant with a lysine deletion in the central protein region, carriers of which have increased atherosclerosis risk.	Lysine	62-68	apolipoprotein A-I	Cricetulus griseus	0-6
23456478-5	2013	ApoA-I Helsinki (or  K107) is a natural apoA-I variant with a lysine deletion in the central protein region, carriers of which have increased atherosclerosis risk.	Lysine	62-68	apolipoprotein A-I	Cricetulus griseus	40-46
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	trithorax	Drosophila melanogaster	67-76
23459941-1	2013	The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4.	Lysine	165-171	trithorax	Drosophila melanogaster	78-81
23585276-8	2013	This domain contains the IGF2 gene and is marked by a histone H3 lysine 27 trimethylation block between CTCF site upstream of the IGF2 promoters and the Centrally Conserved Domain upstream of the ICR.	Lysine	65-71	CCCTC-binding factor	Homo sapiens	104-108
23658530-2	2013	We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by de-methylation of histone H3 at lysine 27 by KDM6A, a histone demethylase with female-biased expression.	Lysine	110-116	reproductive homeobox 6	Mus musculus	48-59
23595999-0	2013	Histone H4 lysine 16 acetylated isoform synthesis opens new route to biophysical studies.	Lysine	11-17	H4 clustered histone 9	Homo sapiens	0-10
23595999-1	2013	Histone H4 lysine acetylation regulated by MOF (males absent on the first) was initially discovered as a dosage compensation epigenetic mark.	Lysine	11-17	H4 clustered histone 9	Homo sapiens	0-10
23576758-6	2013	We show that the lysine-specific demethylase 1 and repressor element-1 silencing transcription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is required for full developmental silencing of mouse embryonic beta-like globin genes and human gamma-globin genes in adult erythroid cells in vivo.	Lysine	17-23	hemoglobin subunit gamma 1	Homo sapiens	281-293
23417673-7	2013	In this way, we demonstrate that DNA damage leads to (i) an enhanced HDAC4/Ubc9 interaction, (ii) the activation of SIRT1 by SUMOylation (Lys-734), and (iii) the SUMO-dependent recruitment of HDAC4 by SIRT1 which permits the deacetylation/SUMOylation switch of HIC1.	Lysine	138-141	sirtuin 1	Homo sapiens	116-121
23575859-8	2013	Increased gene expression of c-Fos and Nr4a2 is correlated with decreased HDAC3 occupancy and increased histone H4 lysine 8 acetylation at their promoters.	Lysine	115-121	nuclear receptor subfamily 4, group A, member 2	Mus musculus	39-44
24216980-5	2013	Following ZEB1 induction, acetylation of histone H4 and histone H3 on lysine 9 (H3K9) and 27 (H3K27) was decreased on ZEB1 binding sites on these genes as demonstrated by chromatin immunoprecipitation.	Lysine	70-76	zinc finger E-box binding homeobox 1	Homo sapiens	10-14
24216980-5	2013	Following ZEB1 induction, acetylation of histone H4 and histone H3 on lysine 9 (H3K9) and 27 (H3K27) was decreased on ZEB1 binding sites on these genes as demonstrated by chromatin immunoprecipitation.	Lysine	70-76	zinc finger E-box binding homeobox 1	Homo sapiens	118-122
22213190-7	2013	Inhibition of Mat1a expression was associated with an increase in histone H3 lysine 27 trimethylation and a decrease in histone H3 lysine 18 acetylation at the gene promoter/first exon region.	Lysine	77-83	methionine adenosyltransferase 1A	Rattus norvegicus	14-19
22213190-7	2013	Inhibition of Mat1a expression was associated with an increase in histone H3 lysine 27 trimethylation and a decrease in histone H3 lysine 18 acetylation at the gene promoter/first exon region.	Lysine	131-137	methionine adenosyltransferase 1A	Rattus norvegicus	14-19
23363599-7	2013	San1 prevents this by containing no lysines in its disordered regions; thus the canonical residue used for ubiquitin attachment has been selectively eliminated.	Lysine	36-43	ubiquitin-protein ligase SAN1	Saccharomyces cerevisiae S288C	0-4
23593017-7	2013	RTT109 encodes an acetyl transferase that acetylates lysine 56 of histone H3 and which functions in replication-coupled nucleosome assembly.	Lysine	53-59	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	0-6
23507839-6	2013	Znf198, stabilizes the LSD1-CoREST-HDAC complex that removes, via lysine demethylase1 (LSD1), the activating trimethylation of H3 on lysine-4 (H3K4me3).	Lysine	66-72	zinc finger MYM-type containing 2	Homo sapiens	0-6
23507839-6	2013	Znf198, stabilizes the LSD1-CoREST-HDAC complex that removes, via lysine demethylase1 (LSD1), the activating trimethylation of H3 on lysine-4 (H3K4me3).	Lysine	66-72	lysine demethylase 1A	Homo sapiens	23-27
23507839-6	2013	Znf198, stabilizes the LSD1-CoREST-HDAC complex that removes, via lysine demethylase1 (LSD1), the activating trimethylation of H3 on lysine-4 (H3K4me3).	Lysine	66-72	lysine demethylase 1A	Homo sapiens	87-91
23383965-3	2013	The protein was designed, cloned, expressed, and purified with lysine present in the elastin repeats.	Lysine	63-69	elastin	Homo sapiens	85-92
22986503-3	2013	provided proof of concept by identifying chemical matters that inhibit demethylation mediated by the two related histone H3 lysine 27 demethylases, KDM6A and 6B (UTX and JMJD3).	Lysine	124-130	lysine demethylase 6B	Homo sapiens	170-175
23381138-2	2013	Recruitment of TRAF6 to the receptor-associated IRAK1-IRAK4-MyD88 adaptor protein complex induces lysine 63 (K63) autopolyubiquitination of TRAF6, which leads to further recruitment of downstream regulators, such as TAB2/3 and TAK1, and subsequently triggers NF-kappaB activation.	Lysine	98-104	interleukin 1 receptor associated kinase 4	Homo sapiens	54-59
23263990-4	2013	In this study, we generated mouse embryonic stem (ES) cells for the inducible expression of JMJD2B (also known as KDM4B), a demethylase that primarily removes the histone-3 lysine-9 trimethylation (H3K9me3) mark.	Lysine	173-179	lysine (K)-specific demethylase 4B	Mus musculus	92-98
23263990-4	2013	In this study, we generated mouse embryonic stem (ES) cells for the inducible expression of JMJD2B (also known as KDM4B), a demethylase that primarily removes the histone-3 lysine-9 trimethylation (H3K9me3) mark.	Lysine	173-179	lysine (K)-specific demethylase 4B	Mus musculus	114-119
23297412-6	2013	We found that SIRT1 induced p300 down-regulation via the ubiquitin-proteasome pathway by deacetylation of lysine residues for ubiquitination.	Lysine	106-112	E1A binding protein p300	Mus musculus	28-32
9928251-1	1998	Previous studies from our laboratory have shown that the 5-HT2C serotonin receptor can be rendered constitutively active by changing amino acid 312 (third intracellular loop) from serine to lysine (S312K).	Lysine	190-196	5-hydroxytryptamine receptor 2C	Homo sapiens	57-63
9988531-5	1998	A third GST-CK fusion protein was identical to CK8fexcept that the C-terminal lysine was mutated to glutamine (CK8fK483Q).	Lysine	78-84	keratin 8	Homo sapiens	47-50
9792179-2	1998	In recent years a growing number of venoms from snakes of Agkistrodon, Bothrops and Trimeresurus species have been shown to contain a catalytically inactive PLA2-homologue in which the highly conserved aspartic acid at position 49 (Asp49) is substituted by lysine (Lys49).	Lysine	257-263	phospholipase A2 group IIA	Homo sapiens	157-161
9826199-1	1998	The importance in catalysis of the conserved arginine (R207) and lysine residues (K144, K294, K356, and K425) of 6-phosphoglucose isomerase from Bacillus stearothermophilus was assessed by site-directed mutagenesis and kinetic analysis.	Lysine	65-71	glucose-6-phosphate isomerase	Sus scrofa	115-139
9770363-2	1998	The lysine-rich H1(0) histone differs from the other H1 histones with respect to its mode of expression and to the processing of the respective mRNA.	Lysine	4-10	H1.0 linker histone	Homo sapiens	16-21
9819765-5	1998	Hamster MCS also shared aa identity of 64.4% with mouse MCS and contained an Arg-Lys-Ser-Thr-rich region in the N-terminus similar to the mitochondrial targeting signal.	Lysine	81-84	sperm mitochondria-associated cysteine-rich protein	Rattus norvegicus	8-11
9729461-0	1998	Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase.	Lysine	29-35	carbonyl reductase [NADPH] 1	Sus scrofa	76-116
9729461-2	1998	3alpha/beta,20beta-Hydroxysteroid dehydrogenase and carbonyl reductase are members of the short-chain dehydrogenases/reductase family, in which a tyrosine residue and a lysine residue have been identified as catalytically important.	Lysine	169-175	carbonyl reductase [NADPH] 1	Sus scrofa	0-47
10082375-1	1998	Differential chemical modification of the lysines and amino-terminus of Escherichia coli single-strand binding (SSB) protein was used to determine their roles in the binding of SSB to single-stranded DNA (ssDNA).	Lysine	42-49	single-stranded DNA-binding protein	Escherichia coli	112-115
10082375-1	1998	Differential chemical modification of the lysines and amino-terminus of Escherichia coli single-strand binding (SSB) protein was used to determine their roles in the binding of SSB to single-stranded DNA (ssDNA).	Lysine	42-49	single-stranded DNA-binding protein	Escherichia coli	177-180
10082375-10	1998	In the presence of ssDNA, the reactivities of the amino-terminus and Lys residues 43, 62, 73, and 87 were reduced by factors of 3.7-25, indicating that the environments around all of these amines is substantially altered by binding of SSB to ssDNA.	Lysine	69-72	single-stranded DNA-binding protein	Escherichia coli	235-238
9668089-11	1998	The data suggest that substitution of a positive for a negative amino acid at position 45 results in the loss of RFC1 mobility in the absence of small inorganic anions that bind to, and neutralize the positive charge on, the lysine residue.	Lysine	225-231	solute carrier family 19 (folate transporter), member 1	Mus musculus	113-117
9670929-3	1998	One soluble KIR2D, derived from an inhibitory receptor with a long cytoplasmic tail (KIR2DL1), bound to HLA-C allotypes containing asparagine 77 and lysine 80 in the heavy chain, as expected, since these allotypes inhibit lysis by NK cells expressing KIR2DL1.	Lysine	149-155	major histocompatibility complex, class I, C	Homo sapiens	104-109
9702182-7	1998	The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate.	Lysine	60-68	neurofilament light chain	Homo sapiens	77-80
9681684-1	1998	Lysyl oxidase is the extracellular enzyme that catalyzes oxidative deamination of peptidyl-lysine residues in elastin precursors, and lysine and hydroxylysine residues in collagen precursors to form peptidyl-aldehydes.	Lysine	91-97	lysyl oxidase	Rattus norvegicus	0-13
9632111-7	1998	Taken together, these data reveal that the region of hVDR between Arg-49 and Lys-55 contains a novel constitutive nuclear localization signal, RRSMKRK.	Lysine	77-80	vitamin D receptor	Homo sapiens	53-57
9632690-3	1998	Consistently, mutations on the charged surface of the groove (Lys-49, Arg-56, and Arg-60) decrease the binding of 14-3-3zeta to the ligands tested (Zhang, L., Wang, H., Liu, D., Liddington, R., and Fu, H. (1997) J. Biol.	Lysine	62-65	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	114-124
9609693-6	1998	Multiple lysine substitutions (e.g., Thr72,Ser144,Ser228,Ser303--&gt;Lys) have a greater adverse effect than the single lysine mutation, suggesting that in annexin V the introduction of potentially favorable electrostatic interactions between the lysine side chains and the net negatively charged membrane surface is not sufficient to overcome the loss of the hydroxyl side chains.	Lysine	9-15	annexin A5	Rattus norvegicus	156-165
9609693-6	1998	Multiple lysine substitutions (e.g., Thr72,Ser144,Ser228,Ser303--&gt;Lys) have a greater adverse effect than the single lysine mutation, suggesting that in annexin V the introduction of potentially favorable electrostatic interactions between the lysine side chains and the net negatively charged membrane surface is not sufficient to overcome the loss of the hydroxyl side chains.	Lysine	69-72	annexin A5	Rattus norvegicus	156-165
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Lysine	197-205	MIR7-3 host gene	Homo sapiens	71-76
9588171-5	1998	The conversion may be accomplished by another protease(s) with a trypsin-like cleavage specificity, since it is unlikely that the mature TESP1 and TESP2 are capable of splitting the Lys-Ile bond between the light and heavy chains.	Lysine	182-185	protease, serine 40	Mus musculus	147-152
9564917-10	1998	Decreased levels of alpha2-antiplasmin observed suggest that lysine analogs, such as epsilon-aminocaproic acid, may have a beneficial role when locally delivered into the mediastinum.	Lysine	61-67	serpin family F member 2	Homo sapiens	20-38
9507015-6	1998	Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression.	Lysine	17-30	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-151
9521691-13	1998	The lysine and arginine residues in apoB18 may directly interact with negatively charged residues in the MTP molecule, or they may function to maintain the conformation of the recognition site.	Lysine	4-10	microsomal triglyceride transfer protein	Homo sapiens	105-108
9488672-3	1998	Unlike other proteins that interact with heparin via lysine or arginine residues, HPRG relies exclusively on histidine residues for this interaction.	Lysine	53-59	histidine rich glycoprotein	Homo sapiens	82-86
9478981-8	1998	The c-fos mRNA, the expression of which is known to be regulated partly at the stage of transcriptional elongation, appeared earlier in the MEN-expressing cells than in cells transfected with an empty vector or the deletion mutant lacking the lysine-rich region after stimulation with epidermal growth factor.	Lysine	243-249	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
9430678-7	1998	In synapsin I, the Ca2+ requirement for ATP binding is mediated by a single, evolutionarily conserved glutamate residue (Glu373) at a position where synapsin II contains a lysine residue.	Lysine	172-178	synapsin I	Homo sapiens	3-13
9483794-0	1998	The lysine-rich C-terminal repeats of the centromere-binding factor 5 (Cbf5) of Kluyveromyces lactis are not essential for function.	Lysine	4-10	pseudouridine synthase CBF5	Saccharomyces cerevisiae S288C	71-75
9389515-13	1997	The dominant negative potency of mutant H was in the rank order of Pal &gt; DR4 &gt; Lys, whereas no TRE dependency was observed for mutant L. The present study indicates that mutations of the TR alpha gene do occur in patients and that these novel TR alpha1 mutants provide a valuable tool to further understand the molecular basis of the dominant negative action of mutant TRs.	Lysine	85-88	T cell receptor alpha locus	Homo sapiens	193-201
9362483-5	1997	We found that three lysine residues and a tyrosine residing in three spatially distinct regions of the AGA polypeptide are necessary for phosphorylation of the oligosaccharides.	Lysine	20-26	aspartylglucosaminidase	Homo sapiens	103-106
9362483-6	1997	Two of the lysines are especially important for the lysosomal targeting efficiency of AGA, which seems to be mostly dictated by the degree of phosphorylation of the alpha subunit oligosaccharide.	Lysine	11-18	aspartylglucosaminidase	Homo sapiens	86-89
9370448-0	1997	Spin-label electron spin resonance studies on the interactions of lysine peptides with phospholipid membranes.	Lysine	66-72	spindlin 1	Homo sapiens	0-4
9341143-7	1997	Deletion analyses of recombinant derivatives of eIF3-p66 show that the RNA-binding domain lies within an N-terminal 71-amino acid region rich in lysine and arginine.	Lysine	145-151	eukaryotic translation initiation factor 3 subunit D	Homo sapiens	48-56
9312154-2	1997	Nop4p is unusual in that it contains four RNA recognition motifs (RRMs) including one noncanonical RRM, as well as several auxiliary motifs, two acidic regions between the RRMs, and a carboxyl-terminal domain rich in lysines and arginines.	Lysine	217-224	mRNA-binding ribosome biosynthesis protein NOP4	Saccharomyces cerevisiae S288C	0-5
9335381-8	1997	dBSA-induced MCP-1 expression was inhibited by lysine, an inhibitor of protein uptake, and reproduced by dBSA purified by gel and size-selective filtration.	Lysine	47-53	chemokine (C-C motif) ligand 2	Mus musculus	13-18
9275185-7	1997	Interestingly, deletion of amino acids 353-835 in the putative C-terminal regulatory region, or mutation of Lys-35 in the putative ATP-binding domain, markedly reduced the ability of GLK to activate JNK.	Lysine	108-111	glucokinase	Homo sapiens	183-186
10325639-6	1997	144 codon was mutated from CAG to AAG, so Gln was substituted by Lys.	Lysine	65-68	N-methylpurine DNA glycosylase	Homo sapiens	34-37
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	38-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	38-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-118
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	97-100	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	97-100	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-118
9240451-3	1997	Identification of lactosylated sites by trypsinolysis and Tandem MS indicate that, although the glycosylation reaction was non-specific and potentially involved all the reactive sites (alpha- and epsilon-amino groups), beta-LG appeared to have at least two populations of lysine with the distinct ability to react with lactose.	Lysine	272-278	beta-lactoglobulin	Bos taurus	219-226
9153260-8	1997	Thrombin specifically cleaved chicken OPN at two sites: between Arg-22 and Ser-23, which generated the 5-kDa N-terminal end fragment, and another between Lys-138 and Ala-139, which generated the 30- and 20-kDa fragments.	Lysine	154-157	coagulation factor II, thrombin	Gallus gallus	0-8
9180275-1	1997	The Candida albicans CAN1 gene, encoding a high-affinity permease for arginine, lysine and histidine, was tagged at its C-terminus with a c-myc epitope and introduced into strains of Saccharomyces cerevisiae lacking basic amino acid permeases.	Lysine	80-86	arginine permease CAN1	Saccharomyces cerevisiae S288C	21-25
9207844-0	1997	Cloning and expression of an Arabidopsis thaliana cDNA encoding a monofunctional aspartate kinase homologous to the lysine-sensitive enzyme of Escherichia coli.	Lysine	116-122	Aspartate kinase family protein	Arabidopsis thaliana	81-97
9207844-1	1997	As in many bacterial species, the first enzymatic reaction of the aspartate-family pathway in plants is mediated by several isozymes of aspartate kinase (AK) that are subject to feedback inhibition by the end-product amino acids lysine or threonine.	Lysine	229-235	Aspartate kinase family protein	Arabidopsis thaliana	136-152
9207844-1	1997	As in many bacterial species, the first enzymatic reaction of the aspartate-family pathway in plants is mediated by several isozymes of aspartate kinase (AK) that are subject to feedback inhibition by the end-product amino acids lysine or threonine.	Lysine	229-235	Aspartate kinase family protein	Arabidopsis thaliana	154-156
9207844-5	1997	Moreover, similar to the bacterial lysine-sensitive AK, the polypeptide encoded by the present cDNA is monofunctional and does not contain and HSD domain.	Lysine	35-41	Aspartate kinase family protein	Arabidopsis thaliana	52-54
9207844-6	1997	These observations imply that our cloned cDNA encodes a lysine-sensitive AK.	Lysine	56-62	Aspartate kinase family protein	Arabidopsis thaliana	73-75
9207844-8	1997	This was confirmed by the independent cloning of an additional Arabidopsis cDNA encoding a lysine-sensitive AK (see accompanying paper).	Lysine	91-97	Aspartate kinase family protein	Arabidopsis thaliana	108-110
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Lysine	73-76	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	47-51
9092533-7	1997	However Lys-9, the unique lysine residue in the NH2-terminal region of IkappaBbeta, is not absolutely required for its degradation.	Lysine	8-11	NFKB inhibitor beta	Homo sapiens	71-82
9092533-7	1997	However Lys-9, the unique lysine residue in the NH2-terminal region of IkappaBbeta, is not absolutely required for its degradation.	Lysine	26-32	NFKB inhibitor beta	Homo sapiens	71-82
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Lysine	137-143	antioxidant 1 copper chaperone	Homo sapiens	192-196
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Lysine	250-256	antioxidant 1 copper chaperone	Homo sapiens	192-196
9083055-4	1997	Yeast strains lacking copper/zinc superoxide dismutase (SOD1) are sensitive to redox cycling agents and dioxygen and are auxotrophic for lysine when grown in air, and expression of this human ATX1 homologue (HAH1) in these strains restored growth on lysine-deficient media.	Lysine	250-256	antioxidant 1 copper chaperone	Homo sapiens	208-212
9089338-5	1997	In contrast to Boc-CCK-4, which is 70-fold selective for the CCK-B receptor, the modified lysine-bearing tetrapeptides were highly potent and selective full agonists at the CCK-A receptor.	Lysine	90-96	cholecystokinin A receptor	Homo sapiens	173-187
9089338-6	1997	Further investigation of the structure-activity profile following modification of the substituted phenylurea moiety appended off the lysine revealed that moving certain substituents, e.g. nitro or acetyl, from the 2- or 3-position on the phenyl ring to the 4-position, a relatively minor and subtle structural modification within the tetrapeptide, resulted in loss of CCK-A receptor selectivity and development of a trend toward CCK-B selectivity.	Lysine	133-139	cholecystokinin A receptor	Homo sapiens	368-382
9054374-5	1997	PTH-generated IPs were reduced to 27 +/- 13% when K319E, compared with the WT receptor, and PLC activation was fully recovered in a receptor revertant in which Glu-319 in the DSEL mutant cassette was restored to the WT residue, Lys.	Lysine	228-231	parathyroid hormone	Sus scrofa	0-3
9075934-2	1997	Using site-directed mutagenesis, residues on HLA-C that determine the locus specificity (alphaVal-76), allotype group specificity (a dimorphism alphaAsn-80/Lys-80), and affinity of NKIR binding (a second pair of dimorphisms, alphaAla-73, Asp-90 or alphaThr-73, Ala-90) have been identified.	Lysine	156-159	major histocompatibility complex, class I, C	Homo sapiens	45-50
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	histidine rich glycoprotein	Homo sapiens	0-4
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	histidine rich glycoprotein	Homo sapiens	73-77
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	histidine rich glycoprotein	Homo sapiens	73-77
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	histidine rich glycoprotein	Homo sapiens	73-77
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	histidine rich glycoprotein	Homo sapiens	73-77
9102401-8	1997	HPRG-enhanced plasminogen activation was proportional to the quantity of HPRG immobilized and was abolished by anti-HPRG antiserum, by low concentrations of epsilon-aminocaproic acid, by methylation of lysine residues in HPRG, and by treatment of HPRG with carboxypeptidase B.	Lysine	202-208	carboxypeptidase B1	Homo sapiens	257-275
9102401-10	1997	The interaction of the conserved C-terminal lysine of HPRG with the high affinity lysine binding site of plasminogen is necessary and sufficient to accelerate plasminogen activation.	Lysine	44-50	histidine rich glycoprotein	Homo sapiens	54-58
9102401-10	1997	The interaction of the conserved C-terminal lysine of HPRG with the high affinity lysine binding site of plasminogen is necessary and sufficient to accelerate plasminogen activation.	Lysine	82-88	histidine rich glycoprotein	Homo sapiens	54-58
8999939-3	1997	In this study, recombinant human IL-15 was PEGylated via lysine-specific conjugation chemistry in order to extend the circulation half-life of this cytokine.	Lysine	57-63	interleukin 15	Homo sapiens	33-38
8999939-6	1997	In comparing sequence alignments and molecular models for IL-2 and IL-15, it was noted that lysine residues resided in regions of IL-15 that may have selectively disrupted receptor subunit binding.	Lysine	92-98	interleukin 15	Homo sapiens	67-72
8999939-6	1997	In comparing sequence alignments and molecular models for IL-2 and IL-15, it was noted that lysine residues resided in regions of IL-15 that may have selectively disrupted receptor subunit binding.	Lysine	92-98	interleukin 15	Homo sapiens	130-135
9010216-5	1997	PACT contains a serine/arginine (SR) rich region and a C" terminal lysine rich domain.	Lysine	67-73	RB binding protein 6, ubiquitin ligase	Homo sapiens	0-4
9029723-16	1997	Superimposition of the nicotinamide rings in the structures of 3 alpha-HSD (an AKR) and 3 alpha, 20 beta-HSD (an SDR) show that the Tyr/Lys pairs are positionally conserved, suggesting convergent evolution across protein families to a common mechanism for HSD catalysis.	Lysine	136-139	aldo-keto reductase family 1, member C14	Rattus norvegicus	63-74
8977249-4	1996	From patient ITP-1 (known to have two distinct autoantibodies), we identified anti-GPIIb/IIIa antibody-specific phage encoding the peptide sequences Arg-Glu-Lys-Ala-Lys-Trp (REKAKW) and Pro-Val-Val-Trp-Lys-Asn (PVVWKN).	Lysine	157-160	integrin subunit alpha 2b	Homo sapiens	83-88
8977249-4	1996	From patient ITP-1 (known to have two distinct autoantibodies), we identified anti-GPIIb/IIIa antibody-specific phage encoding the peptide sequences Arg-Glu-Lys-Ala-Lys-Trp (REKAKW) and Pro-Val-Val-Trp-Lys-Asn (PVVWKN).	Lysine	165-168	integrin subunit alpha 2b	Homo sapiens	83-88
8906845-4	1996	Several synthetic LBP peptides inhibited LPS-LBP interaction, and amino acids Arg 94 and Lys 95 were centrally located in these inhibitory peptides.	Lysine	89-92	lipopolysaccharide binding protein	Homo sapiens	18-21
8875911-6	1996	This is the first discovery to show the interconversion of DAP-SI and synthesis of lysine from them by protozoa.	Lysine	83-89	death-associated protein 1	Capra hircus	59-65
8875911-7	1996	In B suspensions, mixed DAP-SI decreased by 10.92% as a whole and converted to lysine by 4.20% during 12 h incubation.	Lysine	79-85	death-associated protein 1	Capra hircus	24-30
8875911-8	1996	When a single DAP-SI was added to the media, meso-, L- and D-DAP were interconverted and then converted to lysine by the rumen bacteria as well as the protozoa.	Lysine	107-113	death-associated protein 1	Capra hircus	14-20
8920857-0	1996	Glu227--&gt;Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.	Lysine	12-15	CD8a molecule	Homo sapiens	133-136
8920857-0	1996	Glu227--&gt;Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.	Lysine	12-15	CD8a molecule	Homo sapiens	169-172
8920857-4	1996	A Glu/Asp227--&gt;Lys substitution in the class I alpha 3 domain acidic loop abrogates lysis of target cells expressing these mutant molecules by alloreactive CD8-dependent CTL.	Lysine	18-21	CD8a molecule	Homo sapiens	159-162
8920857-11	1996	Thus the Glu227--&gt;Lys mutation effectively distinguishes CD8 coreceptor and avidity-enhanced CD8 accessory functions.	Lysine	21-24	CD8a molecule	Homo sapiens	60-63
8920857-11	1996	Thus the Glu227--&gt;Lys mutation effectively distinguishes CD8 coreceptor and avidity-enhanced CD8 accessory functions.	Lysine	21-24	CD8a molecule	Homo sapiens	96-99
8948100-10	1996	Deletion of the LYS1 gene resulted in a Lys- phenotype.	Lysine	40-43	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	16-20
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Lysine	155-161	methylisocitrate lyase ICL2	Saccharomyces cerevisiae S288C	45-49
8923736-8	1996	We have also shown that the product of LYS20 is responsible for the greater part of the lysine production.	Lysine	88-94	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	39-44
8923736-9	1996	The different isoforms are sensitive to inhibition by lysine but only the expression of LYS20 is strongly repressed by lysine.	Lysine	54-60	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	88-93
8923736-9	1996	The different isoforms are sensitive to inhibition by lysine but only the expression of LYS20 is strongly repressed by lysine.	Lysine	119-125	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	88-93
23414755-6	2013	XopD colocalized with SlERF4 in subnuclear foci and catalyzed SUMO1 hydrolysis from lysine 53 of SlERF4, causing SlERF4 destabilization.	Lysine	84-90	ethylene response factor 4	Solanum lycopersicum	22-28
23414755-6	2013	XopD colocalized with SlERF4 in subnuclear foci and catalyzed SUMO1 hydrolysis from lysine 53 of SlERF4, causing SlERF4 destabilization.	Lysine	84-90	ethylene response factor 4	Solanum lycopersicum	97-103
23414755-6	2013	XopD colocalized with SlERF4 in subnuclear foci and catalyzed SUMO1 hydrolysis from lysine 53 of SlERF4, causing SlERF4 destabilization.	Lysine	84-90	ethylene response factor 4	Solanum lycopersicum	97-103
23414755-7	2013	Mutation of lysine 53 prevented SlERF4 sumoylation, decreased SlERF4 levels, and reduced SlERF4 transcription.	Lysine	12-18	ethylene response factor 4	Solanum lycopersicum	32-38
23414755-7	2013	Mutation of lysine 53 prevented SlERF4 sumoylation, decreased SlERF4 levels, and reduced SlERF4 transcription.	Lysine	12-18	ethylene response factor 4	Solanum lycopersicum	62-68
23414755-7	2013	Mutation of lysine 53 prevented SlERF4 sumoylation, decreased SlERF4 levels, and reduced SlERF4 transcription.	Lysine	12-18	ethylene response factor 4	Solanum lycopersicum	62-68
23220553-5	2013	This cleavage event is indistinguishable from the N-terminal cleavage of OPA1 observed in CGNs undergoing caspase-mediated apoptosis (Loucks et al., 2009) and results in removal of a key lysine residue (K301) within the GTPase domain.	Lysine	187-193	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	73-77
23246116-4	2013	We constructed a phage library displaying lysine-deficient structural variants of LTalpha with randomized amino acid residues.	Lysine	42-48	lymphotoxin alpha	Homo sapiens	82-89
23246116-5	2013	After affinity panning, we screened three clones of lysine-deficient LTalpha mutant, and identified a LTalpha mutant with TNFR1-mediated bioactivity that was 32 times that of the wild-type LTalpha (wtLTalpha).	Lysine	52-58	lymphotoxin alpha	Homo sapiens	69-76
22899583-8	2013	In addition, suppressive trimethylation of histone H3 lysine 27 of important T-cell transcription factor genes (GATA3, LEF1, TCF1) was present in anaplastic large cell lymphoma cells, which is in line with their absence in primary tumor specimens as demonstrated by immunohistochemistry.	Lysine	54-60	GATA binding protein 3	Homo sapiens	112-117
22899583-9	2013	Our data suggest that epigenetically activated suppressors (e.g. ID2) contribute to the down-regulation of the T-cell expression program in anaplastic large cell lymphoma, which is maintained by trimethylation of histone H3 lysine 27.	Lysine	224-230	inhibitor of DNA binding 2	Homo sapiens	65-68
23293348-9	2013	Green fluorescence protein-fused aux1(rcr1) was localized in the cytoplasm and probably not to the plasma membrane, indicating important roles of the Lys(126) residue at loop 2 in AUX1 targeting.	Lysine	150-153	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	33-37
8790154-0	1996	Fibrinogen Matsumoto II: gamma 308 Asn--&gt;Lys (AAT--&gt;AAG) mutation associated with bleeding tendency.	Lysine	44-47	N-methylpurine DNA glycosylase	Homo sapiens	58-61
14519104-8	2004	All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue.	Lysine	64-70	cullin CUL3	Saccharomyces cerevisiae S288C	34-39
9064323-7	1996	Comparative protein modeling and electrostatic calculations disclosed that mMCP-6 contains a prominent Lys/Arg-rich domain on its surface, distant from the active site.	Lysine	103-106	tryptase beta 2	Mus musculus	75-81
8976129-15	1996	A variant TTR, characterized by a Glu61--&gt;Lys substitution (a basic-for-acidic amino acid substitution) found in this family, has not been reported in the literature.	Lysine	45-48	transthyretin	Homo sapiens	10-13
14519104-9	2004	These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p.	Lysine	32-38	cullin CUL3	Saccharomyces cerevisiae S288C	159-164
23889988-1	2013	Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002.	Lysine	71-77	CEA cell adhesion molecule 1	Homo sapiens	83-90
14752010-10	2004	Thus, like histone H3 lysine 4 and lysine 79 methylation, two modifications that it regulates, Rad6-directed H2B ubiquitylation defines regions of active chromatin.	Lysine	22-28	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	95-99
8702612-2	1996	A previously characterized Factor XIIIa fibrin lysine labeling system was employed to localize sites of donor activity based on their covalent incorporation of a synthetic peptide acceptor substrate analog modelled after the NH2-terminal cross-linking domain of alpha2 antiplasmin.	Lysine	47-53	serpin family F member 2	Homo sapiens	262-280
14752010-10	2004	Thus, like histone H3 lysine 4 and lysine 79 methylation, two modifications that it regulates, Rad6-directed H2B ubiquitylation defines regions of active chromatin.	Lysine	35-41	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	95-99
8663386-4	1996	Lysines are the only residues to be engaged in the dimerization with human retinoid X receptor alpha (hRXRalpha) in the absence of DNA, whereas histidines are selectively involved in the homodimerization of hRARalpha in the presence of a RARE.	Lysine	0-7	retinoid X receptor alpha	Homo sapiens	75-100
23000340-9	2013	Mutational analysis of the magnesium coordinating lysine-290 within the bZip, in vitro and intracellular interaction assays and luciferase reporter-gene assays revealed that the effect of lithium on the CREB-CRTC interaction or on the transcriptional activity, respectively, was not affected by the mutation, thus excluding a magnesium-lithium competition.	Lysine	50-56	cAMP responsive element binding protein 1	Homo sapiens	203-207
23000340-10	2013	However, the CREB-CRTC interaction was strongly increased in lysine-290-mutants thereby extending the CRTC-CREB interaction domain.	Lysine	61-67	cAMP responsive element binding protein 1	Homo sapiens	13-17
8663386-4	1996	Lysines are the only residues to be engaged in the dimerization with human retinoid X receptor alpha (hRXRalpha) in the absence of DNA, whereas histidines are selectively involved in the homodimerization of hRARalpha in the presence of a RARE.	Lysine	0-7	retinoid X receptor alpha	Homo sapiens	102-111
8663386-6	1996	Modified lysines, interfering with the dimerization with hRXRalpha, were identified by receptor labeling and peptide mapping.	Lysine	9-16	retinoid X receptor alpha	Homo sapiens	57-66
23000340-10	2013	However, the CREB-CRTC interaction was strongly increased in lysine-290-mutants thereby extending the CRTC-CREB interaction domain.	Lysine	61-67	cAMP responsive element binding protein 1	Homo sapiens	107-111
15663355-3	2004	MLL1 regulates Hox gene expression via direct promoter binding and histone H3 Lys 4 methylation mediated by the intrinsic methyltransferase activity of the SET domain.	Lysine	78-81	lysine methyltransferase 2A	Homo sapiens	0-4
23856557-2	2013	Here, we report that Prdm12 recruits G9a to methylate histone H3 on lysine 9 through its zinc finger domains.	Lysine	68-74	PR/SET domain 12	Homo sapiens	21-27
8663302-0	1996	Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis.	Lysine	0-6	heat shock protein family A (Hsp70) member 8	Bos taurus	35-40
14978339-2	2004	Twenty-nine spontaneous mutants from the hybrid CCMV capable of systemic infection in cowpea appeared through biased codon changes that resulted in Lys or Arg at five specific positions in the MP gene.	Lysine	148-151	movement protein	Cowpea chlorotic mottle virus	193-195
8700541-1	1996	The PDGF beta-receptor in which the active-site lysine in the kinase domain has been mutated to arginine (K634R) tacks intrinsic kinase activity.	Lysine	48-54	platelet derived growth factor subunit B	Homo sapiens	4-13
23182424-9	2013	These results suggest that the conserved lysine of the Walker A motif in hDMC1 plays a key role in ATP binding.	Lysine	41-47	DNA meiotic recombinase 1	Homo sapiens	73-78
14673179-5	2004	IKKbeta-induced degradation is dependent on SCF(beta-TrCP), which acts through multiple lysine residues in the IkappaBgamma domain.	Lysine	88-94	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	0-7
23182424-11	2013	Our results provide evidence that the conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding which is required for presynaptic filament formation.	Lysine	48-54	DNA meiotic recombinase 1	Homo sapiens	80-85
23430810-2	2013	Antiquitin deficiency, caused by mutations in ALDH7A1, is a disorder of the lysine degradation pathway causing accumulation of an intermediate that complexes with pyridoxal phosphate.	Lysine	76-82	aldehyde dehydrogenase 7 family member A1	Homo sapiens	46-53
8757502-8	1996	32Dkit cells transfected with bcr/abl containing an inactivating point mutation (Lys--&gt;Arg271) in the Abl kinase domain (32Dp210(Arg271)kit) retained their responsiveness to the effects of rhSF.	Lysine	81-84	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	30-37
8757502-8	1996	32Dkit cells transfected with bcr/abl containing an inactivating point mutation (Lys--&gt;Arg271) in the Abl kinase domain (32Dp210(Arg271)kit) retained their responsiveness to the effects of rhSF.	Lysine	81-84	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-108
8670792-6	1996	Substitution of an arginine for the conserved lysine residue in the ATPase domain of Pxaaa1p abolished its biological activity, suggesting that Pxaaa1p is an ATPase.	Lysine	46-52	peroxisomal biogenesis factor 6	Homo sapiens	85-92
8670792-6	1996	Substitution of an arginine for the conserved lysine residue in the ATPase domain of Pxaaa1p abolished its biological activity, suggesting that Pxaaa1p is an ATPase.	Lysine	46-52	peroxisomal biogenesis factor 6	Homo sapiens	144-151
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	120-123	translocator protein	Homo sapiens	80-83
24089055-6	2013	Moreover, MTA1 deacetylates BMAL1 at lysine 538 through regulating deacetylase SIRT1 expression, thus disturbing the CRY1-mediated negative feedback loop.	Lysine	37-43	metastasis associated 1	Homo sapiens	10-14
24089055-6	2013	Moreover, MTA1 deacetylates BMAL1 at lysine 538 through regulating deacetylase SIRT1 expression, thus disturbing the CRY1-mediated negative feedback loop.	Lysine	37-43	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	28-33
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	120-123	translocator protein	Homo sapiens	127-130
14673179-5	2004	IKKbeta-induced degradation is dependent on SCF(beta-TrCP), which acts through multiple lysine residues in the IkappaBgamma domain.	Lysine	88-94	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	48-57
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	120-123	translocator protein	Homo sapiens	127-130
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	210-213	translocator protein	Homo sapiens	80-83
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	210-213	translocator protein	Homo sapiens	127-130
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Lysine	28-34	interleukin 13 receptor subunit alpha 1	Homo sapiens	91-101
8661380-5	1996	Our results demonstrate that mutations within the first five nucleotides of the PBS which disrupt base paring with tRNA(Lys,3)-PBS results in an noninfectious virus; a G-U base pair at position six of the tRNA(Lys,3)-PBS complex was tolerated.	Lysine	210-213	translocator protein	Homo sapiens	127-130
8638161-3	1996	In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail.	Lysine	187-190	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	13-19
8638161-3	1996	In addition, CTLA-4 specifically associated with the tyrosine phosphatase SYP, an interaction mediated by the SRC homology 2 (SH2) domains of SYP and the phosphotyrosine sequence Tyr-Val-Lys-Met within the CTLA-4 cytoplasmic tail.	Lysine	187-190	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	206-212
23314848-6	2013	PKL/EPP1 in turn negatively regulates HY5 by repressing trimethylation of histone H3 Lys 27 at the target loci, thereby regulating the expression of these genes and, thus, hypocotyl elongation.	Lysine	85-88	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	0-3
23314848-6	2013	PKL/EPP1 in turn negatively regulates HY5 by repressing trimethylation of histone H3 Lys 27 at the target loci, thereby regulating the expression of these genes and, thus, hypocotyl elongation.	Lysine	85-88	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	4-8
8639710-5	1996	Prior to cross-linking, we acetylated the epsilon-amino groups of the nine lysine residues of TnC in order to prevent intramolecular cross-linking.	Lysine	75-81	tenascin	Oryctolagus cuniculus	94-97
14674748-11	2003	It is suggested that Ser phosphorylation allows protein-protein association by electrostatic stabilization: an obvious negative binding region of Vpu was recognizable by positive residues (Arg and Lys) of the WD domain of beta-TrCP.	Lysine	197-200	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	222-231
14506259-2	2003	The optimal amino acid sequence of substrates for recognition by the cyclin-dependent kinases is well established as -Ser/Thr0-Pro+1-Lys+2-Lys+3-.	Lysine	133-136	lamin A/C	Homo sapiens	127-132
8782344-1	1996	To examine the effect of MDP-Lys(L18), a derivative of muramyl dipeptide (MDP), as a mucosal immunoadjuvant, we investigated its activity to augment host resistance against mucosal infections by Sendai virus and rotavirus in mice.	Lysine	29-32	ribosomal protein L18	Mus musculus	33-36
8782344-6	1996	administration of MDP-Lys(L18) (50 micrograms mouse-1) prior to virus infection markedly reduced rotavirus-induced diarrhea.	Lysine	22-25	ribosomal protein L18	Mus musculus	26-29
8782344-7	1996	Furthermore, when MDP-Lys(L18) was administered p.o.	Lysine	22-25	ribosomal protein L18	Mus musculus	26-29
23555621-8	2013	Finally, a predominant endoproteolytic peptidase specificity for Arg/Lys or Leu/Phe residues in the P(1) position of the scissile bond was found for the TAP-independent ligands.	Lysine	69-72	nuclear RNA export factor 1	Homo sapiens	153-156
23457570-8	2013	Six lysine residues of Osx were identified as candidate ubiquitination sites by construction of point mutant plasmids and luciferase reporter assays.	Lysine	4-10	Sp7 transcription factor 7	Mus musculus	23-26
14667213-5	2003	Whereas H-c[Cys-Phe-Phe-DNal-Lys-Thr-Phe-Cys]-OH (ODN-8, 2) has high affinity and marginal selectivity for human sst(3) (Reubi et al., Proc.	Lysine	29-32	sushi, nidogen and EGF like domains 1	Homo sapiens	113-119
23358114-4	2013	We report that Nurr1 is SUMOylated by SUMO-2 in the lysine 91 located in the transcriptional activation function 1 domain of Nurr1.	Lysine	52-58	nuclear receptor subfamily 4 group A member 2	Homo sapiens	15-20
14701874-3	2003	We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1.	Lysine	110-117	protein inhibitor of activated STAT 1	Homo sapiens	224-229
23358114-4	2013	We report that Nurr1 is SUMOylated by SUMO-2 in the lysine 91 located in the transcriptional activation function 1 domain of Nurr1.	Lysine	52-58	small ubiquitin like modifier 2	Homo sapiens	38-44
23358114-4	2013	We report that Nurr1 is SUMOylated by SUMO-2 in the lysine 91 located in the transcriptional activation function 1 domain of Nurr1.	Lysine	52-58	nuclear receptor subfamily 4 group A member 2	Homo sapiens	125-130
23358114-9	2013	Furthermore, lysine 91, the major target of Nurr1 SUMOylation is contained in a canonical synergy control motif, indicating that SUMO-2 posttranslational modification of Nurr1 regulates its transcriptional synergy in complex promoters.	Lysine	13-19	nuclear receptor subfamily 4 group A member 2	Homo sapiens	44-49
23358114-9	2013	Furthermore, lysine 91, the major target of Nurr1 SUMOylation is contained in a canonical synergy control motif, indicating that SUMO-2 posttranslational modification of Nurr1 regulates its transcriptional synergy in complex promoters.	Lysine	13-19	small ubiquitin like modifier 2	Homo sapiens	129-135
23358114-9	2013	Furthermore, lysine 91, the major target of Nurr1 SUMOylation is contained in a canonical synergy control motif, indicating that SUMO-2 posttranslational modification of Nurr1 regulates its transcriptional synergy in complex promoters.	Lysine	13-19	nuclear receptor subfamily 4 group A member 2	Homo sapiens	170-175
23358114-11	2013	On one hand, PIASgamma limits Nurr1 transactivation in complex promoters by SUMOylating its lysine 91.	Lysine	92-98	protein inhibitor of activated STAT 4	Homo sapiens	13-22
23358114-11	2013	On one hand, PIASgamma limits Nurr1 transactivation in complex promoters by SUMOylating its lysine 91.	Lysine	92-98	nuclear receptor subfamily 4 group A member 2	Homo sapiens	30-35
8612645-5	1996	The initially generated 61--63-kDa vitronectin-(1--348)-fragment serves as typical binding component for plasminogen and binding function was lost upon carboxypeptidase B treatment indicating the importance of a C-terminal lysine.	Lysine	223-229	vitronectin	Homo sapiens	35-46
8647902-2	1996	A transient tyrosine phosphorylation of PDGF beta-receptors was evident one and two hours after cells had been plated on collagen type I and fibronectin, as well as on immobilized anti-integrin subunit IgG, but not on poly-L-lysine.	Lysine	218-231	platelet derived growth factor subunit B	Homo sapiens	40-49
8876379-4	1996	The lysine-rich region KK(X)7KK(X)26KKKK, which plays an important role in nuclear translocation in rabbit FKBP25, was recognized.	Lysine	4-10	peptidyl-prolyl cis-trans isomerase FKBP3	Oryctolagus cuniculus	107-113
14727768-1	2003	A spectrophotometric method based on the reaction between available lysine and ortho-phthaldialdehyde (OPA) was adapted and validated for fluorometric determination of the chemically available lysine contents in milk matrices (UHT and conventional in-bottle sterilized cow milk, milk-based infant formulas and infant formula ingredients).	Lysine	193-199	UHT	Bos taurus	227-230
8655442-13	1995	Inflection point analysis projected maximum ADG at methionine:lysine ratios of 27 and 27.5% for pigs fed 1.4 and 1.8% lysine, respectively.	Lysine	118-124	ADG	Sus scrofa	44-47
8655442-15	1995	Increasing dietary lysine improved (P &lt; .01) ADG and G/F from d 0 to 7, from d 0 to 14, and for the overall experiment.	Lysine	19-25	ADG	Sus scrofa	48-51
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	DExD/H-box helicase 58	Homo sapiens	57-62
14727768-4	2003	The OPA method was used to measure the chemically available lysine contents in UHT and sterilized milk marketed in Spain, to study the evolution of chemically available lysine during the shelf-life of UHT milks, and finally the quality of name- and store-brand UHT milks was also compared.	Lysine	60-66	UHT	Bos taurus	79-82
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	ring finger protein 135	Homo sapiens	97-103
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	DExD/H-box helicase 58	Homo sapiens	191-196
14727768-6	2003	Statistically significant differences (p &lt; 0.05) were found between the chemically available lysine contents in UHT and sterilized milk.	Lysine	96-102	UHT	Bos taurus	115-118
23950712-8	2013	Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase.	Lysine	38-41	DExD/H-box helicase 58	Homo sapiens	191-196
14727768-7	2003	Losses of chemically available lysine ranging from 2.7 to 29% were obtained during the shelf-life of UHT milk.	Lysine	31-37	UHT	Bos taurus	101-104
8593682-3	1995	When cdc2-1 mutant cells, after selective plating, were incubated at the restrictive temperature of 37 degrees C for 5 h daily for 7 days, the frequency of an adaptive reversion of lys(-)--&gt;Lys+ was significantly higher than the frequency in cells incubated only at the permissive temperature, or in wild-type cells incubated either at 23 degrees C or 37 degrees C. Therefore, when the proofreading activity of DNA polymerase delta is impaired under restrictive conditions, the frequency of adaptive mutations is markedly enhanced.	Lysine	181-184	thymidylate synthase	Saccharomyces cerevisiae S288C	5-11
12960171-0	2003	Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.	Lysine	0-7	toll like receptor 4	Homo sapiens	74-94
8593682-3	1995	When cdc2-1 mutant cells, after selective plating, were incubated at the restrictive temperature of 37 degrees C for 5 h daily for 7 days, the frequency of an adaptive reversion of lys(-)--&gt;Lys+ was significantly higher than the frequency in cells incubated only at the permissive temperature, or in wild-type cells incubated either at 23 degrees C or 37 degrees C. Therefore, when the proofreading activity of DNA polymerase delta is impaired under restrictive conditions, the frequency of adaptive mutations is markedly enhanced.	Lysine	193-197	thymidylate synthase	Saccharomyces cerevisiae S288C	5-11
7547922-0	1995	Properties of troponin C acetylated at lysine residues.	Lysine	39-45	tenascin	Oryctolagus cuniculus	14-24
7547922-1	1995	We have studied the properties of rabbit skeletal troponin C (TnC) fully acetylated at its lysine residues (AcTnC).	Lysine	91-97	tenascin	Oryctolagus cuniculus	62-65
7547922-10	1995	These data indicate that positively charged lysine side chains, especially those located in the N-terminal domain, modulate TnC"s structural stability and interactions with Ca2+ and other troponin components.	Lysine	44-50	tenascin	Oryctolagus cuniculus	124-127
23152497-5	2012	KDM6B (also known as JMJD3) is a histone demethylase that might activate gene expression by removing repressive histone H3 lysine 27 trimethylation marks from chromatin.	Lysine	123-129	lysine demethylase 6B	Homo sapiens	0-5
23152497-5	2012	KDM6B (also known as JMJD3) is a histone demethylase that might activate gene expression by removing repressive histone H3 lysine 27 trimethylation marks from chromatin.	Lysine	123-129	lysine demethylase 6B	Homo sapiens	21-26
23152497-9	2012	Chromatin immunoprecipitation (ChIP) assays revealed that KDM6B promoted SNAI1 expression by removing histone H3 lysine trimethylation marks.	Lysine	113-119	lysine demethylase 6B	Homo sapiens	58-63
12972413-3	2003	We found that the PLB monomer with Asn27 or Asn30 changed to Cys (N27C-PLB or N30C-PLB) cross-linked to lysine of SERCA2a within seconds with &gt; or =80% efficiency.	Lysine	104-110	phospholamban	Canis lupus familiaris	18-21
23254293-5	2012	Exogenous GRHL2 expression also inhibited recruitment of histone demethylase Jmjd3 to the EDC gene promoters and enhanced the level of histone 3 Lys 27 trimethylation enrichment at these promoters.	Lysine	145-148	grainyhead like transcription factor 2	Homo sapiens	10-15
23169667-6	2012	Finally, PQLC2 transports a lysine-like mixed disulfide that serves as a chemical intermediate in cysteamine therapy of cystinosis, and PQLC2 gene silencing trapped this intermediate in cystinotic cells.	Lysine	28-34	solute carrier family 66 member 1	Homo sapiens	9-14
7567978-4	1995	The D1 cap region (around the boundary between the CD loop and helix D) of hCNTF, including both Glu-153 and Lys-155, was shown to play a key role in the biological activity of hCNTF as one of the putative receptor-recognition sites.	Lysine	109-112	ciliary neurotrophic factor	Homo sapiens	75-80
7567978-4	1995	The D1 cap region (around the boundary between the CD loop and helix D) of hCNTF, including both Glu-153 and Lys-155, was shown to play a key role in the biological activity of hCNTF as one of the putative receptor-recognition sites.	Lysine	109-112	ciliary neurotrophic factor	Homo sapiens	177-182
7491109-3	1995	Herein we report a study of hVDR in which the functional role of five conserved residues was tested by replacing Phe-244, Lys-246, Leu-254, Gln-259, and Leu-262 with glycines by site-directed mutagenesis.	Lysine	122-125	vitamin D receptor	Homo sapiens	28-32
7491109-9	1995	The possibility also exists that the Lys-246 mutant may be impaired in a step of transactivation that is distal to complex formation with RXR on the VDRE, perhaps in interactions with the transcriptional machinery itself.	Lysine	37-40	retinoid X receptor alpha	Homo sapiens	138-141
12972413-3	2003	We found that the PLB monomer with Asn27 or Asn30 changed to Cys (N27C-PLB or N30C-PLB) cross-linked to lysine of SERCA2a within seconds with &gt; or =80% efficiency.	Lysine	104-110	phospholamban	Canis lupus familiaris	71-74
12972413-3	2003	We found that the PLB monomer with Asn27 or Asn30 changed to Cys (N27C-PLB or N30C-PLB) cross-linked to lysine of SERCA2a within seconds with &gt; or =80% efficiency.	Lysine	104-110	phospholamban	Canis lupus familiaris	71-74
23255816-8	2012	From d 0 to 14, ADG increased (quadratic, P &lt; 0.001) as SID Lys increased from 1.15 to 1.30% with no further increase at greater levels.	Lysine	63-66	ADG	Sus scrofa	16-19
12972413-9	2003	In contrast, Lys3 of PLB did not cross-link to any Lys (or Cys) of SERCA2a, suggesting that previous three-dimensional models that constrain Lys3 near residues 397-400 of thapsigargin-inhibited SERCA2a should be viewed with caution.	Lysine	13-16	phospholamban	Canis lupus familiaris	21-24
23255816-15	2012	Increasing SID Lys from 1.22 to 1.42% increased (quadratic, P &lt; 0.01) ADG and G:F with no further improvement observed in pigs fed the 1.52 or 1.62% SID Lys diets during d 0 to 14.	Lysine	15-18	ADG	Sus scrofa	73-76
7635945-4	1995	DNA sequence analysis of the mutant apoE gene revealed a single-point mutation that resulted in the substitution of glutamic acid (GAG) for lysine (AAG) at residue 146 in the proposed receptor-binding domain of apoE.	Lysine	140-146	N-methylpurine DNA glycosylase	Homo sapiens	148-151
23255816-18	2012	Increasing dietary Lys increased (quadratic, P &lt; 0.02) ADG and G:F with the greatest response observed as SID Lys increased from 1.22 to 1.32% and, then, slight improvements with 1.42 and 1.52% during d 0 to 14.	Lysine	19-22	ADG	Sus scrofa	58-61
14622016-2	2003	ShK-Dap(22), a synthetic derivative in which a diaminopropionic acid residue has been substituted at position Lys(22), has been reported to be a selective K(v)1.3 inhibitor and to block this channel with equivalent potency as ShK [Kalman et al.	Lysine	110-113	sedoheptulokinase	Homo sapiens	0-3
23255816-21	2012	Increasing SID Lys increased (quadratic, P = 0.05) ADG with pigs fed 1.32 and 1.42% SID Lys diets having the greatest BW gains during d 0 to 14.	Lysine	15-18	ADG	Sus scrofa	51-54
23255816-23	2012	One-slope straight broken-line analysis indicated that the SID Lys requirement for optimal growth was at least 1.30% for ADG and 1.37% for G:F, or at least 3.86 and 4.18 g SID Lys/Mcal ME, respectively.	Lysine	63-66	ADG	Sus scrofa	121-124
23255816-24	2012	Quadratic broken-line analysis indicated that the SID Lys requirement for optimal growth was at least 1.37% for ADG and 1.54% for G:F, or at least 4.19 and 4.92 g SID Lys/Mcal ME, respectively.	Lysine	54-57	ADG	Sus scrofa	112-115
7793976-1	1995	In this study, we have spin-labeled the lysine and cysteine residues of low-density lipoprotein (LDL) using N-4-(2,2,6,6-tetramethylpiperidinyl-1-oxyl-4-yl) maleimide (MAL-6) and succinimidyl-2,2,5,5-tetramethyl-3-pyrroline-1-oxyl-3-carboxylate (SSL), respectively.	Lysine	40-46	spindlin 1	Homo sapiens	23-27
23087213-5	2012	Concomitant with a differentiation block, G9a-dependent histone H3 lysine 9 dimethylation (H3K9me2) and MyoD methylation are apparent upon Sharp-1 overexpression in muscle cells.	Lysine	67-73	euchromatic histone lysine methyltransferase 2	Homo sapiens	42-45
12963733-4	2003	The binding site on Chk1 involves a positively charged cluster of amino acids that contains lysine 54, arginine 129, threonine 153, and arginine 162.	Lysine	92-98	checkpoint kinase 1 S homeolog	Xenopus laevis	20-24
23087213-5	2012	Concomitant with a differentiation block, G9a-dependent histone H3 lysine 9 dimethylation (H3K9me2) and MyoD methylation are apparent upon Sharp-1 overexpression in muscle cells.	Lysine	67-73	basic helix-loop-helix family member e41	Homo sapiens	139-146
23157318-6	2012	Thirteen human proteins, including ERCC2 (also known as XPD) and NBR1, gained human-specific ubiquitylated lysines after the human-chimpanzee divergence.	Lysine	107-114	NBR1 autophagy cargo receptor	Homo sapiens	65-69
23105005-1	2012	G9a and GLP are conserved protein methyltransferases that play key roles during mammalian development through mono- and dimethylation of histone H3 Lys 9 (H3K9me1/2), modifications associated with transcriptional repression.	Lysine	148-151	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
7789519-2	1995	By site-directed mutagenesis of the cloned human glucose-6-phosphate dehydrogenase cDNA, lysine 205 (the residue that after reacting with pyridoxal-5"-phosphate renders inactive enzyme) was mutated to threonine (K205T) to remove the amino group, or to arginine (K205R) to displace the position of the amino group, in order to analyze the role of its nucleophilic group in position epsilon.	Lysine	89-95	glucose-6-phosphate dehydrogenase	Homo sapiens	49-82
7789519-4	1995	These findings in the light of the 3D structure of G6PD suggest that the epsilon-amino group of lysine 205 can favour a hydrogen bond within the active pocket essential for catalysis.	Lysine	96-102	glucose-6-phosphate dehydrogenase	Homo sapiens	51-55
7766623-6	1995	Residues in helices I and II also influence DNA binding activity; these oppositely charged residues (e.g., lysine 19 and glutamate 30) may mediate ionic interactions between helices I and II which stabilize DNA binding by Msx-1.	Lysine	107-113	msh homeobox 1	Homo sapiens	222-227
14604673-1	2003	The thioredoxins are small ubiquitous redox proteins with the conserved redox catalytic sequence-Trp-Cys-Gly-Pro-Cys-Lys, where the Cys residues undergo reversible NADPH dependent reduction by selenocysteine containing flavoprotein thioredoxin reductases.	Lysine	117-120	thioredoxin	Homo sapiens	4-16
7539005-8	1995	Mutation of the aspartic acids at positions 137 and 239 to either alanine or lysine completely destroyed ICAM-1 binding.	Lysine	77-83	intercellular adhesion molecule 1	Homo sapiens	105-111
23022381-3	2012	Here we show that the p23 molecular chaperone initiates disassembly of protein-DNA complexes and that the GCN5 acetyltransferase prolongs the dissociated state through lysine acetylation.	Lysine	168-174	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	22-25
23022381-3	2012	Here we show that the p23 molecular chaperone initiates disassembly of protein-DNA complexes and that the GCN5 acetyltransferase prolongs the dissociated state through lysine acetylation.	Lysine	168-174	lysine acetyltransferase 2A	Homo sapiens	106-110
22986735-5	2012	There was a linear relationship between current and lysine concentration ranging from 5.0 to 600 muM for LOx/AuNPs/c-MWCNT/PANI/Au with a detection limit of 5.0 muM, and 20 to 600 muM for the LOx/AuNPs/c-MWCNT/DAB/Au electrode with a detection limit of 20 muM.	Lysine	52-58	lysyl oxidase	Homo sapiens	105-108
7756256-4	1995	Using chemical mapping and site-directed mutation, the site of ubiquitination was localized to a single lysine (K144) near the carboxy terminus of UBC4.	Lysine	104-110	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	147-151
7756256-5	1995	A second lysine within UBC4 (K64) was also identified whose mutation resulted in the loss of ubiquitination at K144.	Lysine	9-15	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	23-27
14604673-1	2003	The thioredoxins are small ubiquitous redox proteins with the conserved redox catalytic sequence-Trp-Cys-Gly-Pro-Cys-Lys, where the Cys residues undergo reversible NADPH dependent reduction by selenocysteine containing flavoprotein thioredoxin reductases.	Lysine	117-120	thioredoxin	Homo sapiens	4-15
14611184-0	2003	Modification of glutamine and lysine residues in holo and apo alpha-lactalbumin with microbial transglutaminase.	Lysine	30-36	lactalbumin alpha	Bos taurus	62-79
7705834-5	1995	We also isolated ferrochelatase cDNAs containing a 18-bp insertion (part of the intron 2 sequence) between exons 2 and 3; this corresponded to six extra amino acids (YESNIR) inserted between Arg-65 and Lys-66 of the known ferrochelatase.	Lysine	202-205	ferrochelatase	Homo sapiens	17-31
22986735-5	2012	There was a linear relationship between current and lysine concentration ranging from 5.0 to 600 muM for LOx/AuNPs/c-MWCNT/PANI/Au with a detection limit of 5.0 muM, and 20 to 600 muM for the LOx/AuNPs/c-MWCNT/DAB/Au electrode with a detection limit of 20 muM.	Lysine	52-58	lysyl oxidase	Homo sapiens	192-195
14611184-3	2003	Modification with microbial Ca(2+) independent transglutaminase (MTGase) was used to modify lysines and glutamines in holo and apo alpha-LA.	Lysine	92-99	lactalbumin alpha	Bos taurus	131-139
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Lysine	160-166	Mig2p	Saccharomyces cerevisiae S288C	22-26
7608924-1	1995	The cytochrome c oxidase subunit II (COII) gene between transfer RNA for Leu and Lys in the mitochondrial DNA of Culex quinquefasciatus Say and Aedes aegypti (L.) was amplified by the polymerase chain reaction (PCR) technique.	Lysine	81-84	COX2	Culex quinquefasciatus	4-35
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Lysine	160-166	Mig2p	Saccharomyces cerevisiae S288C	61-65
14611184-5	2003	At 50 degrees C lysines 13, 16, 108, and 114, but no glutamines, are modified in holo alpha-LA, whereas in apo alpha-LA lysines 5, 13, 16, 108, and 114, and glutamines 39, 43, 54, 65, and 117, are modified.	Lysine	16-23	lactalbumin alpha	Bos taurus	86-94
14611184-5	2003	At 50 degrees C lysines 13, 16, 108, and 114, but no glutamines, are modified in holo alpha-LA, whereas in apo alpha-LA lysines 5, 13, 16, 108, and 114, and glutamines 39, 43, 54, 65, and 117, are modified.	Lysine	120-127	lactalbumin alpha	Bos taurus	111-119
12960019-5	2003	Thus, for RXR heterodimerizing receptors like VDR, the P-box requires redefinition and expansion to include a DNA specificity element corresponding to arg-49 and lys-53 of hVDR.	Lysine	162-165	vitamin D receptor	Rattus norvegicus	46-49
22305405-1	2012	There is evidence that the E3 ubiquitin ligases muscle ring finger-1 (MuRF1) and atrogin-1, which mediate the ubiquitination of certain proteins and thereby their proteolysis, are regulated by cyclical nutritional treatments varying in lysine content.	Lysine	236-242	F-box protein 32	Homo sapiens	81-90
7849299-6	1995	2 had a 3-nucleotide deletion in exon 5 predicting a deletion of a lysine at residue 95, which caused a class 2 variant G6PD Urayasu.	Lysine	67-73	glucose-6-phosphate dehydrogenase	Homo sapiens	120-124
14573629-4	2003	In this study we characterized a Lys/Arg polymorphism at position 29 in the N-terminal region of human lactoferrin that results from a single nucleotide polymorphism in exon 1 of the human lactoferrin gene.	Lysine	33-36	lactotransferrin	Bos taurus	103-114
7758222-14	1995	It could, however, be explained by glycation of lysine residues in apolipoprotein A-I, which is the most potent activator of LCAT.	Lysine	48-54	lecithin-cholesterol acyltransferase	Homo sapiens	125-129
7798276-7	1994	Mutants of the three residues Glu-461, Thr-462, and Lys-463 demonstrate 8-200-fold lower phosphodiesterase specific activity than wild-type Rrp1.	Lysine	52-55	Recombination repair protein 1	Drosophila melanogaster	140-144
7798276-10	1994	Lys-463 and, to a lesser extent, Thr-462 influence the substrate specificity of the Rrp1 nuclease.	Lysine	0-3	Recombination repair protein 1	Drosophila melanogaster	84-88
22974122-2	2012	Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB).	Lysine	24-31	carboxypeptidase B1	Homo sapiens	151-169
22974122-2	2012	Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB).	Lysine	24-31	carboxypeptidase B1	Homo sapiens	171-174
22974122-2	2012	Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB).	Lysine	24-30	carboxypeptidase B1	Homo sapiens	151-169
22974122-2	2012	Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB).	Lysine	24-30	carboxypeptidase B1	Homo sapiens	171-174
22974122-2	2012	Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB).	Lysine	140-147	carboxypeptidase B1	Homo sapiens	171-174
14573629-4	2003	In this study we characterized a Lys/Arg polymorphism at position 29 in the N-terminal region of human lactoferrin that results from a single nucleotide polymorphism in exon 1 of the human lactoferrin gene.	Lysine	33-36	lactotransferrin	Bos taurus	189-200
14573629-7	2003	When tested against the gram-positive species Streptococcus mutans and Streptococcus mitis, however, lactoferrin containing Lys at position 29 exhibited significantly greater bactericidal activity than did lactoferrin containing Arg.	Lysine	124-127	lactotransferrin	Bos taurus	101-112
7830718-7	1994	Having shown a role for the VirB4 protein in DNA transfer, lysine-439, found within the conserved mononucleotide binding domain of VirB4, was changed to a glutamic acid, methionine, or arginine by oligonucleotide-directed mutagenesis.	Lysine	59-65	type IV secretion system protein VirB4	Agrobacterium tumefaciens	28-33
7830718-7	1994	Having shown a role for the VirB4 protein in DNA transfer, lysine-439, found within the conserved mononucleotide binding domain of VirB4, was changed to a glutamic acid, methionine, or arginine by oligonucleotide-directed mutagenesis.	Lysine	59-65	type IV secretion system protein VirB4	Agrobacterium tumefaciens	131-136
14573629-8	2003	In addition, the Lys-containing lactoferrin stimulated bovine tracheal epithelial cells to synthesize much higher levels of tracheal antimicrobial peptide mRNA than did the Arg-containing variant.	Lysine	17-20	lactotransferrin	Bos taurus	32-43
7947774-1	1994	The two active sites in ornithine decarboxylase (ODC) are formed at the dimer interface with Lys-69 and Cys-360 contributing to each active site from opposite monomers [Tobias, K. E., &amp; Kahana, C. (1993) Biochemistry 32, 5842-5847].	Lysine	93-96	ornithine decarboxylase, structural 1	Mus musculus	24-47
22930759-5	2012	TRalpha was sumoylated at lysines 283 and 389, and TRbeta at lysines 50, 146, and 443.	Lysine	26-33	T cell receptor alpha locus	Homo sapiens	0-7
22930759-5	2012	TRalpha was sumoylated at lysines 283 and 389, and TRbeta at lysines 50, 146, and 443.	Lysine	61-68	T cell receptor alpha locus	Homo sapiens	0-7
7947774-1	1994	The two active sites in ornithine decarboxylase (ODC) are formed at the dimer interface with Lys-69 and Cys-360 contributing to each active site from opposite monomers [Tobias, K. E., &amp; Kahana, C. (1993) Biochemistry 32, 5842-5847].	Lysine	93-96	ornithine decarboxylase, structural 1	Mus musculus	49-52
12860992-0	2003	A kinesin switch I arginine to lysine mutation rescues microtubule function.	Lysine	31-37	Kinesin light chain	Drosophila melanogaster	2-9
24178023-3	1994	Two maize (Zea mays L.) threonine-overproducing, lysine-insensitive AK mutants (Ask1-LT19 and Ask2-LT20) were previously isolated.	Lysine	49-55	Shaggy-related protein kinase delta	Zea mays	80-84
23000409-4	2012	CPN cleaves C-terminal lysine and arginine residues from several proteins.	Lysine	23-29	carboxypeptidase N subunit 1	Homo sapiens	0-3
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	67-74	H3 histone pseudogene 16	Homo sapiens	25-28
22893703-2	2012	Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechanisms, but a number of questions remain to be addressed.	Lysine	108-114	interleukin 12A	Homo sapiens	20-25
22902619-0	2012	Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.	Lysine	76-82	lymphocyte cytosolic protein 2	Homo sapiens	104-110
7926838-4	1994	When the N-terminal, lysine- and arginine-rich domain of Nsr1 was removed, the truncated protein behaved similarly to hnRNP A1; furthermore, the two RRM (RNA recognition motif) domains of Nsr1 behaved in the same manner as the two RRM domains of hnRNP A1.	Lysine	21-27	Nsr1p	Saccharomyces cerevisiae S288C	57-61
7948863-6	1994	The other polypeptide, LTI30, consists of several lysine-rich repeats, a structure found in CAP85, a low temperature- and water stress-responsive protein in spinach [41] and similar proteins found in wheat [20].	Lysine	50-56	dehydrin family protein	Arabidopsis thaliana	23-28
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	67-74	H3 histone pseudogene 16	Homo sapiens	33-36
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	67-74	H3 histone pseudogene 16	Homo sapiens	33-36
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	67-74	H3 histone pseudogene 16	Homo sapiens	33-36
24900424-0	2012	SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington"s Disease.	Lysine	19-25	sarcosine dehydrogenase	Homo sapiens	0-3
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	140-147	H3 histone pseudogene 16	Homo sapiens	25-28
22705350-0	2012	Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.	Lysine	0-6	ubiquitin conjugating enzyme E2 B	Homo sapiens	22-27
8091650-7	1994	When the P6 aspartic acid was changed to asparagine, lysine, or serine, NS3-mediated cleavage occurred.	Lysine	53-59	KRAS proto-oncogene, GTPase	Homo sapiens	72-75
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	140-147	H3 histone pseudogene 16	Homo sapiens	33-36
22705350-6	2012	Lysine to arginine mutations within repeats 5-7 identified K394 as the major Rad6B ubiquitination site in vitro and in vivo, and confirmed by Rad6B ubiquitination of a beta-catenin peptide encompassing K394.	Lysine	0-6	ubiquitin conjugating enzyme E2 B	Homo sapiens	77-82
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	140-147	H3 histone pseudogene 16	Homo sapiens	33-36
8086489-8	1994	These results demonstrate that Lys-161 of the receptor is important for high affinity binding with ET-3 which, in part, confers the non-selective binding characteristics of the ETB receptor for ET isopeptides.	Lysine	31-34	endothelin 3	Homo sapiens	99-103
14532004-3	2003	Ubiquitinylated forms of p21 and p21(K0), a p21 mutant missing all lysines, are detected in vivo and in vitro, showing that the presence of lysines is dispensable for p21 ubiquitinylation.	Lysine	140-147	H3 histone pseudogene 16	Homo sapiens	33-36
14532004-5	2003	Although wild-type p21 is more abundantly ubiquitinylated than p21(K0) mutant due to the presence of internal lysine residues, their rates of proteolysis are indistinguishable.	Lysine	110-116	H3 histone pseudogene 16	Homo sapiens	19-22
7849073-7	1994	This value is &gt; 20 times larger than values obtained for GOx-ferrocene derivatives in which surface lysine residues were covalently modified using identical coupling reagents and similar reaction conditions.	Lysine	103-109	hydroxyacid oxidase 1	Homo sapiens	60-63
22807577-6	2012	The two most effective consisted of our anti-FcRL5 antibody conjugated through cysteines to monomethylauristatin E (MMAE) by a maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl (MC-vcPAB) linker (anti-FcRL5-MC-vcPAB-MMAE) or conjugated via lysines to the maytansinoid DM4 through a disulfide linker (anti-FcRL5-SPDB-DM4).	Lysine	250-257	Fc receptor like 5	Homo sapiens	45-50
14532004-5	2003	Although wild-type p21 is more abundantly ubiquitinylated than p21(K0) mutant due to the presence of internal lysine residues, their rates of proteolysis are indistinguishable.	Lysine	110-116	H3 histone pseudogene 16	Homo sapiens	63-66
12949703-0	2003	Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome.	Lysine	71-77	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	99-103
22983119-2	2012	Replacement of valine at position 787 in the S6 segment of homology domain II of the rat Na(v)1.4 sodium channel by lysine (V787K) enchances slow inactivation of this channel whereas replacement by alanine or cysteine (V787A and V787C) inhibits slow inactivation.	Lysine	116-122	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	89-97
8063713-9	1994	The third substrate, NFF-3 (Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2), was hydrolyzed rapidly by MMP-3 (kcat/Km = 218,000 s-1 M-1) and very slowly by MMP-9 (kcat/Km = 10,100 s-1 M-1), but there was no significant hydrolysis by MMP-1 and MMP-2.	Lysine	40-43	matrix metallopeptidase 9	Homo sapiens	162-167
7815475-6	1994	The NGF triple mutant Lys-32/Lys-34/Glu-35 to Ala, which has been demonstrated to bind to p140trkA, but not to p75NGFR, induced tyrosine phosphorylation more rapidly than wild-type NGF.	Lysine	22-25	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	90-98
7815475-6	1994	The NGF triple mutant Lys-32/Lys-34/Glu-35 to Ala, which has been demonstrated to bind to p140trkA, but not to p75NGFR, induced tyrosine phosphorylation more rapidly than wild-type NGF.	Lysine	29-32	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	90-98
22829592-0	2012	Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation.	Lysine	61-67	TNF receptor associated factor 6	Rattus norvegicus	71-76
14561489-4	2003	In this study we generated a mutant granulocyte colony-stimulating factor (G-CSF) termed G-CSF.E20K in which this residue is substituted to Lys.	Lysine	140-143	colony stimulating factor 3	Homo sapiens	36-73
7531278-9	1994	In contrast, hCG beta(Lys-54) associated very poorly with alpha.	Lysine	22-25	chorionic gonadotropin subunit beta 3	Homo sapiens	13-21
7959867-5	1994	Both PHA-activated CD4+ and CD8+ T cells have increased lysine transport through y+, and in seven out of eight experiments, more activity was seen in the CD8+ fraction.	Lysine	56-62	CD8a molecule	Homo sapiens	28-31
7959867-5	1994	Both PHA-activated CD4+ and CD8+ T cells have increased lysine transport through y+, and in seven out of eight experiments, more activity was seen in the CD8+ fraction.	Lysine	56-62	CD8a molecule	Homo sapiens	154-157
14561489-4	2003	In this study we generated a mutant granulocyte colony-stimulating factor (G-CSF) termed G-CSF.E20K in which this residue is substituted to Lys.	Lysine	140-143	colony stimulating factor 3	Homo sapiens	75-80
14561489-4	2003	In this study we generated a mutant granulocyte colony-stimulating factor (G-CSF) termed G-CSF.E20K in which this residue is substituted to Lys.	Lysine	140-143	colony stimulating factor 3	Homo sapiens	89-94
14521589-2	2003	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase that, after activation, can attenuate plasmin-mediated fibrin degradation by removing the C-terminal lysine residues from fibrin, which play a role in the binding and activation of plasminogen.	Lysine	177-183	carboxypeptidase B2 (plasma)	Mus musculus	0-43
8196644-6	1994	Furthermore, one point mutant with only a single glutamine on this surface altered to lysine abolished the ability of the Kruppel protein to repress, indicating the importance of the amino acid at residue 86 for repression.	Lysine	86-92	Kruppel	Drosophila melanogaster	122-129
7920863-1	1994	Complementary DNA clones have been isolated recently from rat (D2) and rabbit kidney (rBAT) which induce increased Na(+)-independent Leu and Lys transport activities (System b0, +) when expressed in oocytes of Xenopus laevis.	Lysine	141-144	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	86-90
22829592-7	2012	Fe(2+) stimulates Lys(63)-linked polyubiquitination (polyUb) of TRAF6 in caveosomes, and a dominant negative K63R mutant of ubiquitin or SOD prevents iron-induced TRAF6 polyUb and TAK1 activation.	Lysine	18-21	TNF receptor associated factor 6	Rattus norvegicus	64-69
14521589-2	2003	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a procarboxypeptidase that, after activation, can attenuate plasmin-mediated fibrin degradation by removing the C-terminal lysine residues from fibrin, which play a role in the binding and activation of plasminogen.	Lysine	177-183	carboxypeptidase B2 (plasma)	Mus musculus	45-49
13679578-0	2003	ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3.	Lysine	75-81	absent, small, or homeotic discs 1	Drosophila melanogaster	0-4
22696202-0	2012	Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage.	Lysine	25-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	57-64
22696202-6	2012	In this study we have investigated whether the expression of BCR-ABL could influence the acetylation of p53, specifically at lysine 317/320 (K317/K320), which has been shown to regulate nuclear export and transcription-independent apoptotic activity of p53.	Lysine	125-131	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-68
7912945-11	1994	The results showed a point mutation in the PrP gene at codon 200; GAG to AAG (Glu--&gt;Lys).	Lysine	87-90	N-methylpurine DNA glycosylase	Homo sapiens	73-76
12832454-10	2003	The UBA domains bind to the surface of Ub including Lys-48, which is required for multiubiquitin assembly, possibly explaining the observed inhibition of multiubiquitination by hHR23B.	Lysine	52-55	RAD23 homolog B, nucleotide excision repair protein	Homo sapiens	177-183
7818846-4	1994	Moreover, excess lysine could inhibit the binding of tPA to the 45-kDa protein in both coincubation and reversibility experiments.	Lysine	17-23	chromosome 20 open reading frame 181	Homo sapiens	53-56
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Lysine	27-33	vitamin D receptor	Homo sapiens	14-18
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Lysine	27-33	vitamin D receptor	Homo sapiens	150-154
22878891-7	2012	Here, we report that histone H3 acetylation (H3Ac) and H3 lysine 4 tri-methylation (H3K4me3) levels at LHY, CCA1, and TOC1 are positively correlated with the rhythmic transcript levels of these genes, whereas H3K36me2 level shows a negative correlation.	Lysine	58-64	Homeodomain-like superfamily protein	Arabidopsis thaliana	103-106
22771996-2	2012	The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.	Lysine	67-73	euchromatic histone lysine methyltransferase 2	Homo sapiens	17-20
14522900-11	2003	In addition, we found that p33(ING1b) physically interacts with hSIR2, reverses its ability to induce the AFP promoter, and induces acetylation of p53 residues at Lys(373) and/or Lys(382).	Lysine	163-166	inhibitor of growth family member 1	Homo sapiens	27-30
22871331-2	2012	Polycomb group proteins EED, SUZ12, and EZH2 have been shown to mediate methylation of the lysine 27 residue of histone protein H3 (H3K27), an epigenetic mark that is linked with transcriptional repression.	Lysine	91-97	embryonic ectoderm development	Homo sapiens	24-27
8147100-1	1994	The antimetastatic effects of MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide (MDP), against three different types of highly metastatic murine tumour cells, B16-BL6 melanoma, colon 26-M3.1 carcinoma and L5178Y-ML25 T lymphoma, were examined in C57BL/6, Balb/c and CDF1 mice, respectively.	Lysine	34-37	ribosomal protein L18	Mus musculus	38-41
14522900-11	2003	In addition, we found that p33(ING1b) physically interacts with hSIR2, reverses its ability to induce the AFP promoter, and induces acetylation of p53 residues at Lys(373) and/or Lys(382).	Lysine	179-182	inhibitor of growth family member 1	Homo sapiens	27-30
12826662-5	2003	Substitution of Glu-590 with neutral uncharged residues (alanine and glutamine) and/or a basic positively charged residue (lysine) significantly increased L-CPTI malonyl-CoA sensitivity to the level observed with the muscle isoform of the enzyme, suggesting the importance of neutral and/or positive charges in the switch of the kinetic properties of L-CPTI to the muscle isoform of CPTI.	Lysine	123-129	carnitine palmitoyltransferase 1A	Rattus norvegicus	155-161
8289272-2	1994	A site-specific lysine to methionine mutation has been engineered at the invariant Lys35 residue in the ATPase A binding site of the Escherichia coli uvrD gene encoding DNA helicase II.	Lysine	16-22	ATPase	Escherichia coli	104-110
7508709-1	1994	Lysyl oxidase (LO) is an extracellular copper-dependent enzyme that catalyzes the initial reaction in the formation of lysine or hydroxylysine-derived crosslinks during collagen biosynthesis.	Lysine	119-125	lysyl oxidase	Homo sapiens	0-13
22691107-2	2012	G9a is a key enzyme for histone H3 dimethylation at position lysine-9.	Lysine	61-67	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
22802671-1	2012	The complex of lysine-specific demethylase-1 (LSD1/KDM1A) with its corepressor protein CoREST is an exceptionally relevant target for epigenetic drugs.	Lysine	15-21	lysine demethylase 1A	Homo sapiens	46-50
12826662-5	2003	Substitution of Glu-590 with neutral uncharged residues (alanine and glutamine) and/or a basic positively charged residue (lysine) significantly increased L-CPTI malonyl-CoA sensitivity to the level observed with the muscle isoform of the enzyme, suggesting the importance of neutral and/or positive charges in the switch of the kinetic properties of L-CPTI to the muscle isoform of CPTI.	Lysine	123-129	carnitine palmitoyltransferase 1A	Rattus norvegicus	157-161
7508709-1	1994	Lysyl oxidase (LO) is an extracellular copper-dependent enzyme that catalyzes the initial reaction in the formation of lysine or hydroxylysine-derived crosslinks during collagen biosynthesis.	Lysine	119-125	lysyl oxidase	Homo sapiens	15-17
12915472-8	2003	Taken together, our data imply that the Xi adopts a distinct chromatin configuration in interphase nuclei and are consistent with a mechanism by which HP1, through histone H3 lysine-9 methylation, recognizes and assists in maintaining heterochromatin and gene silencing at the human Xi.	Lysine	175-181	chromobox 5	Homo sapiens	151-154
8290340-3	1993	Here, we examined the potential dual roles of the flanking lysine and arginine residues in influencing the redox reactivity of the cysteine and the DNA-binding activity of Fos and Jun.	Lysine	59-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-175
8290340-5	1993	Mutation of the lysine in Fos-Jun heterodimers had no obvious effect on the redox reactivity of the cysteine, suggesting that lysine is not essential in this respect.	Lysine	16-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-29
8290340-11	1993	This suggests that the lysine and arginine residues in the KCR region of Fos are not equivalent to those in Jun and that they interact with DNA differently.	Lysine	23-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-76
22802671-1	2012	The complex of lysine-specific demethylase-1 (LSD1/KDM1A) with its corepressor protein CoREST is an exceptionally relevant target for epigenetic drugs.	Lysine	15-21	lysine demethylase 1A	Homo sapiens	51-56
12820959-0	2003	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	Lysine	83-89	catenin beta 1	Homo sapiens	31-43
22722849-3	2012	Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells.	Lysine	67-73	sirtuin 7	Homo sapiens	18-23
8299962-5	1993	The first Leu of the putative leucine zipper of D. melanogaster PARP is substituted to Lys in X. laevis PARP.	Lysine	87-90	poly(ADP-ribose) polymerase 1 L homeolog	Xenopus laevis	104-108
12820959-0	2003	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	Lysine	83-89	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	15-25
12820959-3	2003	The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB, and directs the SCF(beta-TrCP1) to ubiquitinate these proteins at specific lysines.	Lysine	208-215	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	18-28
8280084-5	1993	The specificity of calmodulin-dependent protein kinase-II resembled that of MAPKAP kinase-2, except that it could tolerate replacement of the arginine by a lysine and the phosphorylation-site serine by a threonine residue.	Lysine	156-162	MAPK activated protein kinase 2	Homo sapiens	76-91
12820959-3	2003	The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB, and directs the SCF(beta-TrCP1) to ubiquitinate these proteins at specific lysines.	Lysine	208-215	catenin beta 1	Homo sapiens	107-119
22728861-2	2012	Recently an autosomal recessive deficiency in Antiquitin (ALDH7A1), a gene involved in the catabolism of lysine has been identified as the underlying cause.	Lysine	105-111	aldehyde dehydrogenase 7 family member A1	Homo sapiens	58-65
12820959-3	2003	The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB, and directs the SCF(beta-TrCP1) to ubiquitinate these proteins at specific lysines.	Lysine	208-215	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	153-163
12820959-6	2003	The model"s prediction that the lysine-destruction motif spacing is a determinant of ubiquitination efficiency is confirmed by measuring ubiquitination rates of mutant beta-catenin peptides, solidifying the model and also providing a mechanistic basis for lysine selection.	Lysine	32-38	catenin beta 1	Homo sapiens	168-180
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	0-6	sirtuin 1	Homo sapiens	32-37
8232554-6	1993	Some single glutamate-to-lysine mutations completely abolish micromolar Ca2+ block, indicating that the pore does not possess any high-affinity binding site that acts independently of the four glutamate residues.	Lysine	25-31	carbonic anhydrase 2	Homo sapiens	72-75
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	0-6	lysine acetyltransferase 5	Homo sapiens	67-72
12820959-6	2003	The model"s prediction that the lysine-destruction motif spacing is a determinant of ubiquitination efficiency is confirmed by measuring ubiquitination rates of mutant beta-catenin peptides, solidifying the model and also providing a mechanistic basis for lysine selection.	Lysine	256-262	catenin beta 1	Homo sapiens	168-180
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	0-6	lysine acetyltransferase 5	Homo sapiens	144-149
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	47-54	sirtuin 1	Homo sapiens	32-37
12637503-0	2003	Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain.	Lysine	145-151	LDL receptor related protein associated protein 1	Homo sapiens	99-126
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	47-54	lysine acetyltransferase 5	Homo sapiens	67-72
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Lysine	47-54	lysine acetyltransferase 5	Homo sapiens	144-149
22549777-3	2012	Here we show that GLI2 is conjugated by small ubiquitin-like modifier (SUMO) at lysine residues 630 and 716 in the cell.	Lysine	80-86	GLI-Kruppel family member GLI2	Mus musculus	18-22
22493455-0	2012	Significance of calcium binding, tyrosine phosphorylation, and lysine trimethylation for the essential function of calmodulin in vertebrate cells analyzed in a novel gene replacement system.	Lysine	63-69	calmodulin 2	Gallus gallus	115-125
8192894-8	1993	The present study identifies a regulatory function of Lys for the multifunctional activities of liver alcohol dehydrogenase.	Lysine	54-57	aldo-keto reductase family 1 member A1	Homo sapiens	102-123
7902322-1	1993	Lysyl oxidase (EC 1.4.3.13), an extracellular copper enzyme, initiates the crosslinking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues.	Lysine	187-193	lysyl oxidase	Homo sapiens	0-13
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	95-101	LDL receptor related protein associated protein 1	Homo sapiens	60-63
8361486-7	1993	This is related to the distinctions in the electron seeking properties of the Schiff bases produced by PLP with alpha-NH2 groups of Val-1 and epsilon-NH2 groups of lysine residues of the protein alpha- and beta-chains.	Lysine	164-170	proteolipid protein 1	Homo sapiens	103-106
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	95-101	LDL receptor related protein associated protein 1	Homo sapiens	218-221
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	112-115	LDL receptor related protein associated protein 1	Homo sapiens	60-63
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	112-115	LDL receptor related protein associated protein 1	Homo sapiens	218-221
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	124-127	LDL receptor related protein associated protein 1	Homo sapiens	60-63
8512325-7	1993	As in other HMG-17 proteins, the sequence is characterized by a lysine- and proline-rich central region, which has been implicated in DNA binding.	Lysine	64-70	high mobility group nucleosomal binding domain 2	Homo sapiens	12-18
22451663-4	2012	Plasminogen binds to C3, C3b, C3d, and C5 via lysine residues, and the interaction is ionic strength-dependent.	Lysine	46-52	plasminogen	Oryctolagus cuniculus	0-11
12637503-5	2003	These objectives were accomplished by random mutagenesis of RAP, which identified two critical lysine residues, Lys-256 and Lys-270, within the carboxyl-terminal domain that are necessary for binding of this region of RAP to LRP and to heparin.	Lysine	124-127	LDL receptor related protein associated protein 1	Homo sapiens	218-221
8383676-3	1993	The bacterially expressed and purified Cdc34 protein is shown here to catalyze its own ubiquitination via an intramolecular transfer of its thiol ester-linked ubiquitin to a lysine.	Lysine	174-180	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	39-44
8383676-6	1993	The 4 Lys residues (Lys273, Lys277, Lys293, and Lys294) in this region of CDC34 were substituted by arginine either singly or in combination to produce a set of Cdc34 mutants.	Lysine	6-9	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	74-79
22451653-5	2012	Both the recognition of sialylated glycans by the Siglec-15 V-set domain and the association with DAP12 through its Lys-272 are essential for its function.	Lysine	116-119	TYRO protein tyrosine kinase binding protein	Mus musculus	98-103
12637503-6	2003	RAP molecules in which either of these two lysine residues was mutated still bound LRP but with reduced affinity.	Lysine	43-49	LDL receptor related protein associated protein 1	Homo sapiens	0-3
8383676-7	1993	Analysis of these Cdc34 mutants for autoubiquitination revealed that the multiubiquitin chain can be formed on any one of these 4 lysines although most Cdc34 conjugates contain a single multiubiquitin chain.	Lysine	130-137	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	18-23
12717030-6	2003	The structure, chemical shifts, and spin-spin coupling constants all indicate that, of the four lysines in the N-terminal domain of IIA(Glc), only Lys 5 and Lys 7 in the amphipathic helical region interact with DHPG.	Lysine	96-103	colicin Ia immunity protein	Escherichia coli	132-135
8428989-0	1993	Inactivation of the recA protein by mutation of histidine 97 or lysine 248 at the subunit interface.	Lysine	64-70	RAD51 recombinase	Homo sapiens	20-24
8428989-5	1993	To account for these results, we propose that the mutation of either histidine 97 or lysine 248 alters subunit interactions between recA monomers and that this leads to the loss of cooperative single-stranded DNA binding and DNA pairing activities.	Lysine	85-91	RAD51 recombinase	Homo sapiens	132-136
8428989-6	1993	This proposal is consistent with the recently determined x-ray structure of the recA protein, which shows that although histidine 97 and lysine 248 are distant from one another in the monomer structure, these two residues are on the opposing complementary faces of the recA subunit and pack against each other at the interface between adjacent recA monomers in the helical filament (Story, R. M., Weber, I. T., and Steitz, T. A.	Lysine	137-143	RAD51 recombinase	Homo sapiens	80-84
22457348-9	2012	Two amino acids (lysine 715 and arginine 716) of the TRPC4 C terminus were identified by structural modeling as mediating the interaction with Galpha(i2).	Lysine	17-23	transient receptor potential cation channel subfamily C member 4	Homo sapiens	53-58
22660327-7	2012	Surprisingly, hotspots are still observed in Prdm9 knockout mice, and as in wild type, these hotspots are found at H3 lysine 4 (H3K4) trimethylation marks.	Lysine	118-124	PR domain containing 9	Mus musculus	45-50
12683998-0	2003	The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities.	Lysine	17-24	flap structure-specific endonuclease 1	Homo sapiens	34-38
22433856-3	2012	We now show that also Lys(63)-linked ubiquitin chain formation is required for GHR endocytosis.	Lysine	22-25	growth hormone receptor	Homo sapiens	79-82
8472268-8	1993	Elastin from dissected aortas had a higher content of aspartate, threonine, serine, glutamate, and lysine and a lower content of glycine, alanine, and valine than elastin from controls (p &lt; 0.05).	Lysine	99-105	elastin	Homo sapiens	0-7
22510409-5	2012	SIRT1 is also responsible of the deacetylation of the lysine 314 of HIC1 that allows its subsequent SUMOylation which in turn favors its interaction with the NuRD complex.	Lysine	54-60	sirtuin 1	Homo sapiens	0-5
12683998-2	2003	Acetylation occurs at four lysines located at the C terminus of Fen1, which is important for DNA binding.	Lysine	27-34	flap structure-specific endonuclease 1	Homo sapiens	64-68
12683998-3	2003	In this paper we show that Fen1 mutant proteins lacking the lysines at the C terminus have both reduced PCNA independent exonucleolytic and endonucleolytic activities.	Lysine	60-67	flap structure-specific endonuclease 1	Homo sapiens	27-31
8425556-10	1993	The lysine-binding sites are, however, important for the rate of the inhibition of the complexes by alpha 2-antiplasmin.	Lysine	4-10	serpin family F member 2	Homo sapiens	100-119
12683998-3	2003	In this paper we show that Fen1 mutant proteins lacking the lysines at the C terminus have both reduced PCNA independent exonucleolytic and endonucleolytic activities.	Lysine	60-67	proliferating cell nuclear antigen	Homo sapiens	104-108
12713053-3	2003	Protein immobilization occurred through lysine residues participating in electrostatic adsorbed cytochrome c to the resin surface.	Lysine	40-46	cytochrome c, somatic	Equus caballus	96-108
8380333-1	1993	A series of mutations at the highly solvent-exposed lysine 73 of iso-1-cytochrome c have been prepared by site-directed mutagenesis.	Lysine	52-58	eukaryotic translation initiation factor 1	Homo sapiens	65-70
22403408-3	2012	Using a panel of synthetic CCR5 ECL2-derived peptides, we show that the C-terminal portion of ECL2 (2C, comprising amino acids Cys-178 to Lys-191) inhibit HIV-1 entry of both CCR5- and CXCR4-using isolates at low micromolar concentrations.	Lysine	138-141	C-C motif chemokine receptor 5	Homo sapiens	27-31
8428596-10	1993	Mutation of a critical lysine codon (Lys114) believed to be essential for kinase activity abolished both the in vivo mitotic inhibitor function and in vitro kinase activities of human Wee1.	Lysine	23-29	WEE1 G2 checkpoint kinase	Homo sapiens	184-188
22474351-3	2012	Genome-scale location analysis in stem cell-derived postmitotic neurons reveals Top2beta binding to chromosomal sites that are methylated at lysine 4 of histone H3, a feature of regulatory regions.	Lysine	141-147	DNA topoisomerase II beta	Homo sapiens	80-88
12569095-2	2003	A heterodimer composed of the catalytically active ubiquitin-conjugating enzyme hUbc13 and its catalytically inactive paralogue, hMms2, forms the catalytic core for the synthesis of an alternative type of multiubiquitin chain where ubiquitin molecules are tandemly linked to one another through a Lys-63 isopeptide bond.	Lysine	297-300	ubiquitin conjugating enzyme E2 N	Homo sapiens	80-86
22476432-2	2012	In mammals, histone H3 lysine 9 (H3K9)-specific histone methyltransferases (HMTases), such as G9a, SETDB1, and SUV39H, play critical roles, but the contribution of H3K9-specific HMTases in Drosophila remains to be clarified, especially in male sperm.	Lysine	23-29	G9a	Drosophila melanogaster	94-97
1336709-3	1992	We now show that the osteosarcoma cell lines have lost one TP53 allele and contain a mutation in exon 8 codon 286 [GAA to AAA (Glu to Lys)] in the remaining allele.	Lysine	134-137	AAA1	Homo sapiens	122-125
12569095-2	2003	A heterodimer composed of the catalytically active ubiquitin-conjugating enzyme hUbc13 and its catalytically inactive paralogue, hMms2, forms the catalytic core for the synthesis of an alternative type of multiubiquitin chain where ubiquitin molecules are tandemly linked to one another through a Lys-63 isopeptide bond.	Lysine	297-300	ubiquitin conjugating enzyme E2 V2	Homo sapiens	129-134
12763806-0	2003	Single mutation of Lys or Arg residue in ATP binding pocket in rat Na/K-ATPase alpha-1 subunit induces different affinity change in high- and low-affinity ATP binding.	Lysine	19-22	ATPase Na+/K+ transporting subunit alpha 1	Rattus norvegicus	67-94
1448098-8	1992	The gene, named EGD1 (enhancer of GAL4 DNA binding), encodes a highly basic protein (21% lysine and arginine) with a predicted molecular mass of 16.5 kDa.	Lysine	89-95	Egd1p	Saccharomyces cerevisiae S288C	16-20
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Lysine	43-46	Rho family GTPase 3	Homo sapiens	9-13
22275364-4	2012	In contrast, RecA homologs and most RAD51 paralogs contain a conserved lysine at the analogous structural position.	Lysine	71-77	RAD51 recombinase	Homo sapiens	13-17
22275364-4	2012	In contrast, RecA homologs and most RAD51 paralogs contain a conserved lysine at the analogous structural position.	Lysine	71-77	RAD51 recombinase	Homo sapiens	36-41
1463831-2	1992	The gene encodes a hydrophilic, glycine-rich protein (18.5 kDa), which contains the conserved serine- and lysine-rich domains characteristic of similar RAB proteins in other plant species.	Lysine	106-112	RAB GTPASE HOMOLOG B18	Arabidopsis thaliana	152-155
12689588-5	2003	Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure.	Lysine	101-107	embryonic ectoderm development	Mus musculus	38-41
1331081-5	1992	The combined substitution of two regions (amino acids 188-230, particularly lysine 203, and 265-292) from the carboxyl lobe of the lysosomal hydrolase cathepsin D into the homologous positions of the related secretory protein glycopepsinogen was sufficient to confer recognition by phosphotransferase and subsequent phosphorylation of the oligosaccharides when this chimeric protein was expressed in Xenopus oocytes.	Lysine	76-82	cathepsin D	Xenopus laevis	151-162
22262837-8	2012	Mapping of the intermolecular interactions suggested that in addition to the C-terminal residues Thr-His-Val, residues Lys-761 and Tyr-762 in Neph1 are also critical for stabilizing the complex.	Lysine	119-122	kirre like nephrin family adhesion molecule 1	Homo sapiens	142-147
22249179-5	2012	However, TIP60 maintained acetylated Lys-310 RelA/p65 levels in the TNF-alpha-dependent NF-kappaB signaling pathway.	Lysine	37-40	lysine acetyltransferase 5	Homo sapiens	9-14
22249179-7	2012	Chromatin remodeling by TIP60 involved the sequential recruitment of acetyl-Lys-310 RelA/p65 to its target gene promoters.	Lysine	76-79	lysine acetyltransferase 5	Homo sapiens	24-29
12689588-5	2003	Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure.	Lysine	117-123	embryonic ectoderm development	Mus musculus	38-41
12488447-0	2003	High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.	Lysine	53-59	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	25-29
22434628-14	2012	In conclusion, the GLP-1R agonists [Lys(40) (DTPA)]exendin-3 and [Lys(40) (DTPA)]exendin-4 labelled with (111) In could be useful for in vivo GLP-1R targeting, whereas [Lys(40) (DTPA)]exendin(9-39) is not suited for in vivo targeting of the GLP-1R.	Lysine	36-39	glucagon-like peptide 1 receptor	Mus musculus	19-25
22434628-14	2012	In conclusion, the GLP-1R agonists [Lys(40) (DTPA)]exendin-3 and [Lys(40) (DTPA)]exendin-4 labelled with (111) In could be useful for in vivo GLP-1R targeting, whereas [Lys(40) (DTPA)]exendin(9-39) is not suited for in vivo targeting of the GLP-1R.	Lysine	66-69	glucagon-like peptide 1 receptor	Mus musculus	19-25
22434628-14	2012	In conclusion, the GLP-1R agonists [Lys(40) (DTPA)]exendin-3 and [Lys(40) (DTPA)]exendin-4 labelled with (111) In could be useful for in vivo GLP-1R targeting, whereas [Lys(40) (DTPA)]exendin(9-39) is not suited for in vivo targeting of the GLP-1R.	Lysine	66-69	glucagon-like peptide 1 receptor	Mus musculus	19-25
1429612-2	1992	In 1984, a new class of PLA2 was isolated in which this invariant aspartate was replaced with a lysine (Maragnore, J.M., Merutka, G., Cho, W., Welches, W., Kezdy, F.J., and Heinrikson, R.L.	Lysine	96-102	phospholipase A2 group IIA	Homo sapiens	24-28
1429612-13	1992	In this paper, we describe the structures of two crystal forms of the Lys-49 PLA2 isolated from the venom of Agkistridon piscivorus piscivorus.	Lysine	70-73	phospholipase A2 group IIA	Homo sapiens	77-81
1334529-2	1992	IS 1 mutants with a 1 bp insertion, which encode mutant transposases with an amino acid substitution within the polypeptide segment at residues 84-87, did not efficiently mediate cointegration, except for an IS 1 mutant which encodes a mutant transposase with a Leu-Arg-Lys-Leu segment instead of Leu-Lys-Lys-Leu.	Lysine	270-273	IS1	Homo sapiens	0-4
12488447-0	2003	High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.	Lysine	53-59	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	30-34
1334529-2	1992	IS 1 mutants with a 1 bp insertion, which encode mutant transposases with an amino acid substitution within the polypeptide segment at residues 84-87, did not efficiently mediate cointegration, except for an IS 1 mutant which encodes a mutant transposase with a Leu-Arg-Lys-Leu segment instead of Leu-Lys-Lys-Leu.	Lysine	301-304	IS1	Homo sapiens	0-4
1334529-2	1992	IS 1 mutants with a 1 bp insertion, which encode mutant transposases with an amino acid substitution within the polypeptide segment at residues 84-87, did not efficiently mediate cointegration, except for an IS 1 mutant which encodes a mutant transposase with a Leu-Arg-Lys-Leu segment instead of Leu-Lys-Lys-Leu.	Lysine	301-304	IS1	Homo sapiens	0-4
12488447-1	2003	Histone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6.	Lysine	10-16	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	90-94
1334529-3	1992	An IS 1 mutant with the DNA segment 5"-CTTAAAAACTC-3" at positions 305-315 carrying the termination codon TAA in the B"-insB reading frame could still mediate cointegration, indicating that codon AAA for Lys corresponding to second, third and fourth positions in the run of adenines is the site of frameshifting.	Lysine	204-207	IS1	Homo sapiens	3-7
12488447-1	2003	Histone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6.	Lysine	10-16	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	160-164
12488447-1	2003	Histone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6.	Lysine	23-26	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	90-94
22304362-4	2012	We focused on the amino acid residue located at the N-terminus of the PHF6 sequence, serine or lysine in the native isoform of tau, and synthesized the PHF6 derivative peptides with serine or lysine at the N-terminus of PHF6.	Lysine	192-198	PHD finger protein 6	Homo sapiens	152-156
22304362-4	2012	We focused on the amino acid residue located at the N-terminus of the PHF6 sequence, serine or lysine in the native isoform of tau, and synthesized the PHF6 derivative peptides with serine or lysine at the N-terminus of PHF6.	Lysine	192-198	PHD finger protein 6	Homo sapiens	152-156
12488447-1	2003	Histone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6.	Lysine	23-26	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	160-164
1527068-9	1992	The enzyme will also cleave CCK 33 and CCK (1-21) on the carboxyl-terminal side of a single lysine residue in position 11.	Lysine	92-98	cholecystokinin	Rattus norvegicus	28-31
1527068-9	1992	The enzyme will also cleave CCK 33 and CCK (1-21) on the carboxyl-terminal side of a single lysine residue in position 11.	Lysine	92-98	cholecystokinin	Rattus norvegicus	39-42
12488447-4	2003	We report that the majority of Lys(4) methylation in Schizosaccharomyces pombe, like in S. cerevisiae, is mediated by Set1C and is Rad6-dependent.	Lysine	31-34	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	131-135
12667454-2	2003	Methylation of histone H3 on lysines 4 and 79, catalyzed by the Set1-containing complex COMPASS and Dot1p, respectively, is required for silencing of expression of genes located near chromosome telomeres in yeast.	Lysine	29-36	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	64-68
1356443-2	1992	Sequence analysis of the DNA of the proband that was amplified by PCR and subcloned, revealed a single substitution of one lysine (AAG) for one glutamic acid (GAG) at position 146, thereby adding two negatively charged units to apo E3.	Lysine	123-129	N-methylpurine DNA glycosylase	Homo sapiens	131-134
21805138-2	2012	The nuclear amine oxidase, lysine-specific demethylase 1 (LSD1) has the ability to broadly repress gene expression by removing the activating mono- and di-methylation marks at the lysine 4 residue of histone 3 (H3K4me1 and me2).	Lysine	27-33	lysine demethylase 1A	Homo sapiens	58-62
14577167-1	2003	The function of lysine-binding sites in kringle domains K1-4 and K5 of plasminogen (Pg) during its activation by streptokinase (SK) was studied.	Lysine	16-22	keratin 14	Homo sapiens	56-60
22360890-6	2012	NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues.	Lysine	58-64	neurofilament light chain	Homo sapiens	0-4
22159227-4	2012	We identify the lysine residues 120/125 of the E2F1 protein as the prime target sites of Tip60 and show that acetylation at these sites promotes the accumulation of E2F1.	Lysine	16-22	lysine acetyltransferase 5	Homo sapiens	89-94
1390659-5	1992	At the entrance to the heme pocket, the side-chain amino group of lysine-45 (CD3) is well-defined in the electron density map and forms salt-bridging interactions with the heme 6-propionate and with a sulfate ion.	Lysine	66-72	CD3 epsilon subunit of T-cell receptor complex	Sus scrofa	77-80
1526970-3	1992	In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine.	Lysine	260-266	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	127-131
12477715-5	2003	The mutation of a conserved Lys residue in the NLS abolishes nuclear localization of caspase-2 and binding to the importin alpha/beta heterodimer.	Lysine	28-31	caspase 2	Homo sapiens	85-94
1354487-0	1992	Proton transfer roles of lysine 64 and glutamic acid 64 replacing histidine 64 in the active site of human carbonic anhydrase II.	Lysine	25-31	carbonic anhydrase 2	Homo sapiens	107-128
22169219-9	2012	In addition, a lysine mutant of FGFR1, which is preferentially recycled back to the cell surface, promoted elongative axon growth of DRG neurons similar to leupeptin.	Lysine	15-21	Fibroblast growth factor receptor 1	Rattus norvegicus	32-37
22157004-0	2012	RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36.	Lysine	158-164	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	94-98
22157004-1	2012	Methylation of lysine 36 on histone H3 (H3K36) is catalyzed by the Set2 methyltransferase and is linked to transcriptional regulation.	Lysine	15-21	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	67-71
1425958-1	1992	We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.	Lysine	26-31	neurotensin	Mus musculus	105-116
1425958-1	1992	We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.	Lysine	26-31	neurotensin	Mus musculus	202-213
12527890-7	2003	The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation.	Lysine	62-65	epidermal growth factor receptor	Mus musculus	44-48
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Lysine	169-172	kexin KEX2	Saccharomyces cerevisiae S288C	40-44
22214662-3	2012	Here, we report that RAX/PACT interacts with the SUMO E2 ligase Ubc9 to stimulate p53-Ubc9 association and reversible p53 sumoylation on lysine 386.	Lysine	137-143	retina and anterior neural fold homeobox	Homo sapiens	21-24
12527890-8	2003	Furthermore, the mutation at Lys-721 of EGFR resulted in impairing of EGFR autophosphorylation at tyrosine(1173) induced by EGF.	Lysine	29-32	epidermal growth factor receptor	Mus musculus	40-44
12527890-8	2003	Furthermore, the mutation at Lys-721 of EGFR resulted in impairing of EGFR autophosphorylation at tyrosine(1173) induced by EGF.	Lysine	29-32	epidermal growth factor receptor	Mus musculus	70-74
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Lysine	4-7	neurofilament medium chain	Homo sapiens	62-64
12620103-4	2003	Hint is a dimeric enzyme that hydrolyzes AMP linked to lysine, whose enzyme activity is required for regulation of the Cdk7 homologous Kin28 kinase in yeast.	Lysine	55-61	TFIIH complex serine/threonine-protein kinase subunit KIN28	Saccharomyces cerevisiae S288C	135-140
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Lysine	4-7	neurofilament medium chain	Homo sapiens	66-70
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Lysine	4-7	neurofilament medium chain	Homo sapiens	66-68
1379729-5	1992	The Lys-Ser-Pro domain is similar to that of mammalian medium NF (NF-M) and high NF (NF-H) proteins, where the serines are highly phosphorylated.	Lysine	4-7	neurofilament medium chain	Homo sapiens	85-89
23075766-11	2012	CONCLUSION: The present study provides the direct evidence that SIRT1 can inhibit TNF-alpha- induced CD40 expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-kB at lysine 310, which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1.	Lysine	197-203	sirtuin 1	Homo sapiens	64-69
12498693-2	2002	Histone H3 lysine 9 (H3K9) methylation is an epigenetic signal that is recognized by HP1 and correlates with gene silencing in a variety of organisms.	Lysine	11-17	defensin alpha 1	Homo sapiens	85-88
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Lysine	287-293	anon-86Ca	Drosophila melanogaster	259-266
1627572-10	1992	The binding to both surfaces was inhibited by the lysine analogue AMCHA and was completely abolished upon treatment of the degraded surface with carboxypeptidase B, indicating that r-apo(a) binds to both the intrachain lysines of intact fibrin and the carboxy-terminal lysines of degraded fibrin.	Lysine	219-226	carboxypeptidase B1	Homo sapiens	145-163
1627572-10	1992	The binding to both surfaces was inhibited by the lysine analogue AMCHA and was completely abolished upon treatment of the degraded surface with carboxypeptidase B, indicating that r-apo(a) binds to both the intrachain lysines of intact fibrin and the carboxy-terminal lysines of degraded fibrin.	Lysine	269-276	carboxypeptidase B1	Homo sapiens	145-163
12244093-4	2002	This is the result of the large number of lysine and arginine residues scattered over the entire surface of hGIIA, which cause the enzyme to form a supramolecular aggregate with multiple vesicles.	Lysine	42-48	glucosidase II alpha subunit	Homo sapiens	108-113
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Lysine	134-137	kallikrein related peptidase 4	Homo sapiens	4-14
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Lysine	200-203	kallikrein related peptidase 4	Homo sapiens	4-14
21967556-6	2012	DNA analysis showed a single nucleotide mutation at codon 43 of the delta-globin gene (HBD:c.130G&gt;A) causing a glutamic acid to lysine substitution corresponding to Hb A(2)-Melbourne, originally documented in an Italian subject, but not previously described in Thailand.	Lysine	131-137	sodium voltage-gated channel alpha subunit 2	Homo sapiens	168-172
21900421-4	2012	The model predicts that UL98 residues D254, E278 and K280 represent the critical aspartic acid, glutamic acid and lysine active-site residues, respectively, while R164 and S252 correspond to residues proposed to bind the 5" phosphate of the DNA substrate.	Lysine	114-120	deoxyribonuclease	Human betaherpesvirus 5	24-28
12193658-0	2002	Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.	Lysine	11-17	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	47-51
22990868-0	2012	Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.	Lysine	15-21	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-14
22990868-0	2012	Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.	Lysine	15-21	aurora kinase B	Homo sapiens	95-110
22990868-1	2012	Although heat-shock protein 70 (HSP70), an evolutionarily highly conserved molecular chaperone, is known to be post-translationally modified in various ways such as phosphorylation, ubiquitination and glycosylation, physiological significance of lysine methylation has never been elucidated.	Lysine	246-252	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-30
16668921-6	1992	The smaller extensin monomer reported here (Superose-6 peak 2 [SP2]) was compositionally similar to typical dicot extensins such as tomato P1, mainly consisting of Hyp, Thr, Ser, Pro, Val, Tyr, Lys, His, abundant arabinose, and a small but significant galactose content.	Lysine	194-197	extensin-3-like	Solanum lycopersicum	12-20
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Lysine	263-266	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Lysine	277-280	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Lysine	277-280	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
22990868-1	2012	Although heat-shock protein 70 (HSP70), an evolutionarily highly conserved molecular chaperone, is known to be post-translationally modified in various ways such as phosphorylation, ubiquitination and glycosylation, physiological significance of lysine methylation has never been elucidated.	Lysine	246-252	heat shock protein family A (Hsp70) member 4	Homo sapiens	32-37
12193658-4	2002	Unlike in budding yeast, Set1-mediated H3 Lys-4 methylation is not required for heterochromatin assembly at the silent mating-type region and centromeres in fission yeast.	Lysine	42-45	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	25-29
12454455-2	2002	In a previous study using a model system of Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI), it was shown that mutating Lys residues to Ala results in enhanced crystallizability, particularly when clusters of lysines are targeted.	Lysine	136-139	Rho GDP dissociation inhibitor alpha	Homo sapiens	100-106
22990868-2	2012	Here we identify dimethylation of HSP70 at Lys-561 by SETD1A.	Lysine	43-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
1599939-4	1992	Stoichiometry and peptide isolation studies showed that three lysine residues were modified during reaction of GST and PLP.	Lysine	62-68	proteolipid protein 1	Homo sapiens	119-122
1304363-4	1992	The melittin tetramer has two pKa values of 7.5 and 8.5 corresponding to protonation of the N-terminus and Lys 23, respectively.	Lysine	107-110	melittin	Apis mellifera	4-12
12454455-2	2002	In a previous study using a model system of Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI), it was shown that mutating Lys residues to Ala results in enhanced crystallizability, particularly when clusters of lysines are targeted.	Lysine	225-232	Rho GDP dissociation inhibitor alpha	Homo sapiens	100-106
12529759-5	2002	Inhibition of binding of plasminogen and its kringle domains to sTF by the lysine analog 6-aminohexanoic acid (AHA) suggests that lysine-binding sites are involved in plasminogen interaction with TF.	Lysine	75-81	coagulation factor III, tissue factor	Homo sapiens	65-67
22253574-3	2012	We find that Smo is ubiquitinated at multiple Lysine residues including those in its autoinhibitory domain (SAID), leading to endocytosis and degradation of Smo by both lysosome- and proteasome-dependent mechanisms.	Lysine	46-52	smoothened	Drosophila melanogaster	13-16
22253574-3	2012	We find that Smo is ubiquitinated at multiple Lysine residues including those in its autoinhibitory domain (SAID), leading to endocytosis and degradation of Smo by both lysosome- and proteasome-dependent mechanisms.	Lysine	46-52	smoothened	Drosophila melanogaster	157-160
1569080-1	1992	We have recently demonstrated that the Arg-X-Lys/Arg-Arg sequence is a signal for precursor cleavage catalyzed by furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, within the constitutive secretory pathway.	Lysine	45-48	kexin KEX2	Saccharomyces cerevisiae S288C	190-194
12529759-5	2002	Inhibition of binding of plasminogen and its kringle domains to sTF by the lysine analog 6-aminohexanoic acid (AHA) suggests that lysine-binding sites are involved in plasminogen interaction with TF.	Lysine	130-136	coagulation factor III, tissue factor	Homo sapiens	65-67
12369826-5	2002	However, a loss of approximately one ionic interaction on mutation to Arg indicates that the optimal configuration of the network of basic residues of antithrombin that together interact with the pentasaccharide requires a Lys in position 114.	Lysine	223-226	serpin family C member 1	Homo sapiens	151-163
1568251-0	1992	Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei.	Lysine	43-49	histone H4	Drosophila melanogaster	0-10
1568251-1	1992	Histone H4 isoforms acetylated at lysines 5, 8, 12, or 16 have been shown, by indirect immunofluorescence with site-specific antisera, to have distinct patterns of distribution in interphase, polytene chromosomes from Drosophila larvae.	Lysine	34-41	histone H4	Drosophila melanogaster	0-10
22359517-6	2012	Moreover, high levels of histone H3 lysine 4 trimethylation (H3K4me3), which is known to tether the RAG enzyme complex to DNA, were found within the BTG1 gene body in BCP-ALL cells, but not T-ALL cells.	Lysine	36-42	BTG anti-proliferation factor 1	Homo sapiens	149-153
12140285-6	2002	Experiments conducted with two fragments of TP1 containing arginine and lysine residues demonstrated that DNA binding by TP1 must involve more than these basic sequences.	Lysine	72-78	transition protein 1	Homo sapiens	121-124
22719268-4	2012	Here we perform an RNA interference screen against the known histone demethylases and identify a histone H3 lysine 36 (H3K36) demethylase, Jhdm1a, as a key negative regulator of gluconeogenic gene expression.	Lysine	108-114	lysine demethylase 2A	Homo sapiens	139-145
1348749-5	1992	Cathepsin B/L-like activity was determined with Bz-Val-Lys-Lys-Arg-AFC, elastase-like activity with MeOSuc-Ala-Ala-Pro-Val-AFC, tryptase-like activity with Z-Ala-Ala-Lys-AFC, trypsin-like activity with Z-Gly-Gly-Arg-AFC and dipeptidyl peptidase IV-like activity with Ala-Pro-AFC.	Lysine	55-58	cathepsin B	Homo sapiens	0-11
22916091-6	2012	Molecular docking studies predicted that compound 8 binds at the heparin binding domain of VEGF through strong hydrogen bonding with Lys-30 and Gln-20 amino acid residues, and consistent with the prediction, compound 8 inhibited binding of VEGF to immobilized heparin.	Lysine	133-136	vascular endothelial growth factor A	Mus musculus	91-95
12376500-4	2002	We hypothesized that an XPD codon 751 polymorphism (Lys-to-Gln amino acid change) could affect the repair of smoking-induced DNA damage and could be associated with bladder-cancer risk.	Lysine	52-55	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	24-27
22792278-4	2012	The A. thaliana DHDPS enzyme (At-DHDPS2) has similar activity to the bacterial form of the enzyme, but is more strongly allosterically inhibited by (S)-lysine.	Lysine	148-158	dihydrodipicolinate synthase	Arabidopsis thaliana	33-39
22792278-5	2012	Structural studies of At-DHDPS2 show (S)-lysine bound at a cleft between two monomers, highlighting the allosteric site; however, unlike previous studies, binding is not accompanied by conformational changes, suggesting that binding may cause changes in protein dynamics rather than large conformation changes.	Lysine	37-47	dihydrodipicolinate synthase	Arabidopsis thaliana	25-31
1582992-10	1992	Likewise, Oligo-69-84 (corresponding to the PDGF A-chain residues 69-84), with three lysine residues interrupted by a proline, was ineffective.	Lysine	85-91	platelet derived growth factor subunit A	Homo sapiens	44-50
1562515-4	1992	The 286th amino acid of P450(11 beta, aldo)-1 is Glu, while that of P450(11 beta, aldo)-2 is Lys.	Lysine	93-96	aldolase, fructose-bisphosphate A	Rattus norvegicus	24-45
1562515-4	1992	The 286th amino acid of P450(11 beta, aldo)-1 is Glu, while that of P450(11 beta, aldo)-2 is Lys.	Lysine	93-96	aldolase, fructose-bisphosphate B	Rattus norvegicus	68-89
22312437-1	2012	Ezh2 is a histone trimethyltransferase that silences genes mainly via catalyzing trimethylation of histone 3 lysine 27 (H3K27Me3).	Lysine	109-115	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
12376500-10	2002	The combined presence of the NAT1/NAT2 high-risk genotype and the XPD Lys/Lys or Lys/Gln genotypes ignoring smoking had an odds ratio that was only slightly higher than expected, assuming no genotype-genotype interaction (P = 0.52).	Lysine	70-73	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
12376500-10	2002	The combined presence of the NAT1/NAT2 high-risk genotype and the XPD Lys/Lys or Lys/Gln genotypes ignoring smoking had an odds ratio that was only slightly higher than expected, assuming no genotype-genotype interaction (P = 0.52).	Lysine	74-77	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
1737002-3	1992	The assignment of calmodulin in the complex was facilitated by the use of selective labeling of the protein with alpha-15N-labeled valine, alanine, lysine, leucine, and glycine.	Lysine	148-154	calmodulin 2	Gallus gallus	18-28
12376500-10	2002	The combined presence of the NAT1/NAT2 high-risk genotype and the XPD Lys/Lys or Lys/Gln genotypes ignoring smoking had an odds ratio that was only slightly higher than expected, assuming no genotype-genotype interaction (P = 0.52).	Lysine	74-77	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	66-69
12226657-4	2002	PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9.	Lysine	63-69	proliferating cell nuclear antigen	Homo sapiens	0-4
1535317-9	1992	Vasopressin responses to m-CPP were entirely antagonised by the 5-HT1/5-HT2 antagonist metergoline, partially by the 5-HT2/5-HT1C antagonists ritanserin and LY 53857, but not by the 5-HT2 antagonist ketanserin.	Lysine	157-159	5-hydroxytryptamine receptor 2C	Rattus norvegicus	123-129
12226657-4	2002	PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9.	Lysine	63-69	ubiquitin conjugating enzyme E2 V2	Homo sapiens	130-134
22749149-4	2012	Further work has now revealed that Tip60 is activated through direct interaction between Tip60"s chromodomain and histone H3 trimethylated on lysine 9 (H3K9me3).	Lysine	142-148	lysine acetyltransferase 5	Homo sapiens	35-40
22749149-4	2012	Further work has now revealed that Tip60 is activated through direct interaction between Tip60"s chromodomain and histone H3 trimethylated on lysine 9 (H3K9me3).	Lysine	142-148	lysine acetyltransferase 5	Homo sapiens	89-94
1748675-9	1991	These results indicate that lysine 262 in aldose reductase and aldehyde reductase is crucial to their catalytic activity by affecting co-factor binding.	Lysine	28-34	aldo-keto reductase family 1 member A1	Homo sapiens	63-81
12226657-4	2002	PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9.	Lysine	63-69	ubiquitin conjugating enzyme E2 N	Homo sapiens	136-141
12226657-5	2002	All three modifications affect the same lysine residue of PCNA, suggesting that they label PCNA for alternative functions.	Lysine	40-46	proliferating cell nuclear antigen	Homo sapiens	58-62
12226657-5	2002	All three modifications affect the same lysine residue of PCNA, suggesting that they label PCNA for alternative functions.	Lysine	40-46	proliferating cell nuclear antigen	Homo sapiens	91-95
1660471-2	1991	Previously, we generated a lysosomal enzyme recognition domain by substituting two regions (lysine 203 and amino acids 265-292) of the lysosomal hydrolase cathepsin D into a related secretory protein glycopepsinogen.	Lysine	92-98	cathepsin D	Xenopus laevis	155-166
12353073-1	2002	Here we report the finding of a new natural antithrombin mutation that confirms the critical contribution of lysine 114 to the binding of the core heparin pentasaccharide, with the replacement of lysine 114 by glutamate causing a complete loss in affinity.	Lysine	109-115	serpin family C member 1	Homo sapiens	44-56
1939157-3	1991	The 84-residue form of bovine MGP predicted from the message structure could not be detected in the bone extracellular matrix extracts, and it therefore seems probable that the lysine at position 84 was removed by the action of a carboxypeptidase B-like enzyme prior to secretion.	Lysine	177-183	carboxypeptidase B1	Homo sapiens	230-248
22781932-0	2012	IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.	Lysine	87-93	euchromatic histone lysine methyltransferase 2	Homo sapiens	60-65
22781932-2	2012	Of the five histone methyltransferases known to mediate methylation of the lysine 9 residue of histone H3 (H3K9), euchromatic histone-lysine N-methyltransferase 2 (EHMT2; also known as G9a) has been shown to be a primary mediator of H3K9 dimethylation; BIX-01294 has been shown to be a specific inhibitor of EHMT2.	Lysine	75-81	euchromatic histone lysine methyltransferase 2	Homo sapiens	114-162
22781932-2	2012	Of the five histone methyltransferases known to mediate methylation of the lysine 9 residue of histone H3 (H3K9), euchromatic histone-lysine N-methyltransferase 2 (EHMT2; also known as G9a) has been shown to be a primary mediator of H3K9 dimethylation; BIX-01294 has been shown to be a specific inhibitor of EHMT2.	Lysine	75-81	euchromatic histone lysine methyltransferase 2	Homo sapiens	164-169
22781932-2	2012	Of the five histone methyltransferases known to mediate methylation of the lysine 9 residue of histone H3 (H3K9), euchromatic histone-lysine N-methyltransferase 2 (EHMT2; also known as G9a) has been shown to be a primary mediator of H3K9 dimethylation; BIX-01294 has been shown to be a specific inhibitor of EHMT2.	Lysine	75-81	euchromatic histone lysine methyltransferase 2	Homo sapiens	185-188
22781932-2	2012	Of the five histone methyltransferases known to mediate methylation of the lysine 9 residue of histone H3 (H3K9), euchromatic histone-lysine N-methyltransferase 2 (EHMT2; also known as G9a) has been shown to be a primary mediator of H3K9 dimethylation; BIX-01294 has been shown to be a specific inhibitor of EHMT2.	Lysine	75-81	euchromatic histone lysine methyltransferase 2	Homo sapiens	308-313
22169038-5	2011	SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHLH2 on lysine 49 to increase its activation of the MAO-A promoter.	Lysine	85-91	sirtuin 1	Homo sapiens	0-5
12194828-5	2002	This localization requires an N-terminal lysine-rich region that also contains a nuclear localization signal and is enhanced by interaction with Ran.	Lysine	41-47	RAN, member RAS oncogene family	Homo sapiens	145-148
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	168-174	cyclin B2	Mus musculus	126-131
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	272-278	cyclin B2	Mus musculus	126-131
22193451-11	2011	Further, chromatin immunoprecipitation (ChIP) assay indicated that menin affected the histone modification of the promoter of Ccnb2 by reducing the level of histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 acetylation but not affecting the level of histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3).	Lysine	272-278	cyclin B2	Mus musculus	126-131
1718419-8	1991	In contrast, a mutant P68 protein, containing a single amino acid substitution in the invariant lysine in catalytic domain II, was completely inactive.	Lysine	96-102	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	22-25
1937055-5	1991	The role of the KEX2 protease cleavage site was investigated by mutation of the yeast alpha-factor KEX2 site (cleavage after Lys-Arg).	Lysine	125-128	kexin KEX2	Saccharomyces cerevisiae S288C	99-103
12217642-7	2002	Lysine-rich neurofilament protein subunits NF-H and NF-M are more susceptible than lysine-poor NF-L and beta-tubulin to 1,2-DAB.	Lysine	0-6	neurofilament heavy chain	Homo sapiens	43-47
1910042-2	1991	Eleven amino acid substitutions at Val-121 of human carbonic anhydrase II including Gly, Ala, Ser, Leu, Ile, Lys, and Arg, were constructed by site-directed mutagenesis.	Lysine	109-112	carbonic anhydrase 2	Homo sapiens	52-73
21855527-3	2011	In this study, a high-throughput mass spectrometry (HTMS) assay was developed to measure LSD1-catalyzed demethylation of lysine-4 on several H3 substrates.	Lysine	121-127	lysine demethylase 1A	Homo sapiens	89-93
12213448-0	2002	A lysine residue in the beta3 subunit contributes to the regulation of GABA(A) receptor activity by voltage.	Lysine	2-8	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	24-29
22030396-6	2011	Uncoupling FKBP38 from Hsp90 by substituting a conserved lysine in the TPR domain modestly enhances CFTR maturation and further reduces its synthesis.	Lysine	57-63	FKBP prolyl isomerase 8	Homo sapiens	11-17
1840295-6	1991	dMM treatment was found to increase both the lysine affinity and catalytic activity of tPA.	Lysine	45-51	chromosome 20 open reading frame 181	Homo sapiens	87-90
1840295-8	1991	To evaluate the effects of alterations at site 184 and site 448, the catalytic activity and lysine affinity of type I and type II tPA were monitored individually.	Lysine	92-98	chromosome 20 open reading frame 181	Homo sapiens	130-133
1840295-9	1991	In the dMM-treated sample, type I tPA (with sugars at sites 117, 184 and 448) was found to have 2- to 3-fold increased catalytic activity and an affinity for lysine which was greater than that of type I from untreated preparations, but less than that of control type II tPA (containing sugar only at sites 117 and 448).	Lysine	158-164	chromosome 20 open reading frame 181	Homo sapiens	34-37
22001646-6	2011	Intriguingly, nuclear-targeted c-Abl induces heterochromatic profiles of histone methylation and acetylation, including hypoacetylation of histone H4 acetylated on lysine 16 (H4K16Ac).	Lysine	164-170	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	31-36
12213448-7	2002	Conversely, replacing the lysine in the beta3 subunit with threonine resulted in a nearly linear current-voltage relationship and an increased sensitivity to GABA.	Lysine	26-32	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	40-45
22009739-0	2011	Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.	Lysine	146-152	chromodomain Y like	Homo sapiens	20-24
1879833-3	1991	A previously described mutation associated with nonspherocytic hemolytic anemia, G6PD Puerto Limon, was found to be due to a G----A transition at nucleotide (nt) 1192, causing a glu----lys substitution.	Lysine	185-188	glucose-6-phosphate dehydrogenase	Homo sapiens	81-85
12127976-0	2002	Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.	Lysine	0-3	secretoglobin family 1A member 1	Homo sapiens	38-49
1677358-6	1991	In one out of the five subjects with the apoA-IV-1/0 phenotype we identified two point mutations: 1) replacing the positively charged lysine (AAG), amino acid 167, with a negatively charged glutamic acid (GAG), and 2) converting the neutral residue 360, glutamine (CAG), to a positively charged histidine (CAT).	Lysine	134-140	N-methylpurine DNA glycosylase	Homo sapiens	142-145
21994939-4	2011	The ubiquitination sites were mapped to the two lysine residues in the IGF-IR activation loop (Lys-1138 and Lys-1141) and consisted of polyubiquitin chains formed through both Lys-48 and Lys-29 linkages.	Lysine	48-54	insulin like growth factor 1 receptor	Homo sapiens	71-77
21994939-4	2011	The ubiquitination sites were mapped to the two lysine residues in the IGF-IR activation loop (Lys-1138 and Lys-1141) and consisted of polyubiquitin chains formed through both Lys-48 and Lys-29 linkages.	Lysine	95-98	insulin like growth factor 1 receptor	Homo sapiens	71-77
12126930-1	2002	In mammals, the conversion of alpha-aminoadipate to alpha-ketoadipate by alpha-aminoadipate aminotransferase (AADAT) is an intermediate step in lysine degradation.	Lysine	144-150	aminoadipate aminotransferase	Homo sapiens	73-108
21994939-4	2011	The ubiquitination sites were mapped to the two lysine residues in the IGF-IR activation loop (Lys-1138 and Lys-1141) and consisted of polyubiquitin chains formed through both Lys-48 and Lys-29 linkages.	Lysine	108-111	insulin like growth factor 1 receptor	Homo sapiens	71-77
21994939-4	2011	The ubiquitination sites were mapped to the two lysine residues in the IGF-IR activation loop (Lys-1138 and Lys-1141) and consisted of polyubiquitin chains formed through both Lys-48 and Lys-29 linkages.	Lysine	108-111	insulin like growth factor 1 receptor	Homo sapiens	71-77
21994939-4	2011	The ubiquitination sites were mapped to the two lysine residues in the IGF-IR activation loop (Lys-1138 and Lys-1141) and consisted of polyubiquitin chains formed through both Lys-48 and Lys-29 linkages.	Lysine	108-111	insulin like growth factor 1 receptor	Homo sapiens	71-77
21994939-5	2011	Mutation of these ubiquitinated lysine residues resulted in decreased h10H5-induced IGF-IR internalization and down-regulation as well as a reduced cellular response to h10H5 treatment.	Lysine	32-38	insulin like growth factor 1 receptor	Homo sapiens	84-90
1943708-1	1991	Oligonucleotide-directed mutagenesis of ctxB was used to produce mutants of cholera toxin B subunit (CT-B) altered at residues Cys-9, Gly-33, Lys-34, Arg-35, Cys-86 and Trp-88.	Lysine	142-145	phosphate cytidylyltransferase 1B, choline	Homo sapiens	76-99
1674745-7	1991	A second G to A substitution at amino acid 13 led to the exchange of lysine (AAG) for glutamic acid (GAG), thereby adding 2 positive charge units to the protein and producing the apoE-5 variant.	Lysine	69-75	N-methylpurine DNA glycosylase	Homo sapiens	77-80
12126930-1	2002	In mammals, the conversion of alpha-aminoadipate to alpha-ketoadipate by alpha-aminoadipate aminotransferase (AADAT) is an intermediate step in lysine degradation.	Lysine	144-150	aminoadipate aminotransferase	Homo sapiens	110-115
21920659-4	2011	In the present study, citraconylation was employed to neutralize the charges on accessible lysine residues of beta-lg and different approaches such as turbidimetry, thermodynamic analysis, extrinsic fluorimetry and theoretical studies have been successfully used to compare the different behaviors of the native and modified proteins.	Lysine	91-97	beta-lactoglobulin	Bos taurus	110-117
1674861-1	1991	Lysyl oxidase (protein-lysine 6-oxidase; EC 1.4.3.13) is a copper-containing enzyme that functions extracellularly and catalyses the oxidative deamination of peptidyl lysine.	Lysine	23-29	lysyl oxidase	Rattus norvegicus	0-13
12126935-1	2002	The kyphoscoliotic type of Ehlers-Danlos syndrome (EDS type VIA) (OMIM 225400) is an autosomal recessive connective tissue disorder that results from mutations in the lysyl hydroxylase 1 gene (PLOD1) causing underhydroxylation of lysine residues in tissue collagens, particularly of skin.	Lysine	230-236	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	193-198
11914379-3	2002	The contribution of the MHC complex class I light chain, beta(2)-microglobulin, to CD8alphaalpha binding is relatively small and is mediated mainly through the lysine residue at position 58.	Lysine	160-166	beta-2-microglobulin	Homo sapiens	57-78
1902232-5	1991	To investigate whether the phosphorylation of the c-raf protein in intact cells results from an autophosphorylation event or from the phosphorylation by other cellular kinase(s), we replaced lysine 375 in the putative ATP-binding domain of the c-raf protein with alanine using oligonucleotide site-directed mutagenesis and expressed the mutated protein in NIH3T3 cells.	Lysine	191-197	v-raf-leukemia viral oncogene 1	Mus musculus	50-55
11927599-0	2002	Potassium functionally replaces the second lysine of the KMSKS signature sequence in human tyrosyl-tRNA synthetase.	Lysine	43-49	tyrosyl-tRNA synthetase 1	Homo sapiens	91-114
1902103-6	1991	HbA1c did not react with the antibody after removal by immunoadsorption of molecules containing glycated lysine, confirming specificity of the antibody for deoxyfructosyl-lysine residues.	Lysine	171-177	hemoglobin alpha, adult chain 1	Mus musculus	0-4
22064703-3	2011	In this study, we demonstrate that, like UHRF1, UHRF2 also binds preferentially to methylated histone H3 lysine 9 (H3K9) through its conserved tudor domain and hemi-methylated DNA through the SET and Ring associated domain.	Lysine	105-111	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	48-53
11927599-2	2002	In addition, the second lysine in the class I-specific KMSKS signature motif is absent from all known eukaryotic tyrosyl-tRNA synthetase sequences, except those of higher plants.	Lysine	24-30	tyrosyl-tRNA synthetase 1	Homo sapiens	113-136
11927599-3	2002	This lysine, which is the most highly conserved residue in the class I aminoacyl-tRNA synthetase family, has been shown to interact with the pyrophosphate moiety of the ATP substrate in the Bacillus stearothermophilus tyrosyl-tRNA synthetase.	Lysine	5-11	tyrosyl-tRNA synthetase 1	Homo sapiens	218-241
22139571-10	2011	Chromatin immunoprecipitation using antibodies against the acetylated and trimethylated lysine 9 of histone H3 demonstrated low levels of histone methylation in these genes, which are located closest to RASSF1.	Lysine	88-94	Ras association domain family member 1	Homo sapiens	203-209
12023936-0	2002	Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.	Lysine	12-18	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	51-57
22007908-6	2011	Previous studies showed that the stability of endogenous DNMT1 protein is regulated by lysine methylation through histone lysine methyltransferase Set7 and lysine-specific demethylase 1 (LSD1), with the methylated DNMT1 being the target for proteasomal degradation.	Lysine	87-93	lysine demethylase 1A	Homo sapiens	156-185
22007908-6	2011	Previous studies showed that the stability of endogenous DNMT1 protein is regulated by lysine methylation through histone lysine methyltransferase Set7 and lysine-specific demethylase 1 (LSD1), with the methylated DNMT1 being the target for proteasomal degradation.	Lysine	87-93	lysine demethylase 1A	Homo sapiens	187-191
1911941-4	1991	The mechanism of autodigestion is similar to that of a serine protease, and RecA appears to act by reducing the pKa of a critical lysine residue LexA.	Lysine	130-136	RAD51 recombinase	Homo sapiens	76-80
1899843-0	1991	An arginine to lysine substitution in the bZIP domain of an opaque-2 mutant in maize abolishes specific DNA binding.	Lysine	15-21	regulatory protein opaque-2	Zea mays	60-68
22007908-6	2011	Previous studies showed that the stability of endogenous DNMT1 protein is regulated by lysine methylation through histone lysine methyltransferase Set7 and lysine-specific demethylase 1 (LSD1), with the methylated DNMT1 being the target for proteasomal degradation.	Lysine	87-93	DNA methyltransferase 1	Homo sapiens	214-219
11864984-2	2002	Potential insight into the coupling mechanism was provided by our previous finding that mutation to Lys of a single residue (Asp(540)) located in the S4-S5 linker endowed HERG (human ether-a-go-go-related gene) K(+) channels with the unusual ability to open in response to membrane depolarization and hyperpolarization in a voltage-dependent manner.	Lysine	100-103	potassium voltage-gated channel subfamily H member 2	Homo sapiens	171-175
22007908-8	2011	Taken together, our results showed that cyclophosphamide perturbed temporarily global cytosine methylation in Jurkat-T cells via regulation of the lysine methylation level in DNMT1.	Lysine	147-153	DNA methyltransferase 1	Homo sapiens	175-180
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	TNF receptor associated factor 2	Homo sapiens	87-119
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	TNF receptor associated factor 2	Homo sapiens	121-126
21921033-6	2011	We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination.	Lysine	306-309	TNF receptor associated factor 2	Homo sapiens	321-326
1899843-4	1991	We have found that the o2-676 mutant protein does not show specific recognition of zein promoter fragments because of the substitution of a lysine residue for an arginine residue within the bZIP domain of o2-676.	Lysine	140-146	regulatory protein opaque-2	Zea mays	23-25
1899093-3	1991	When expressed in Escherichia coli K12, the recombinant protein was rapidly cleaved upon cell lysis in the lysine-rich C terminus region, probably by the ompT protease.	Lysine	107-113	outer membrane protease	Escherichia coli	154-158
11864984-8	2002	Together these findings suggest that a single residue (Arg(665)) in the S6 domain interacts with Lys(540) by electrostatic repulsion to couple voltage sensing to hyperpolarization-dependent opening of D540K HERG K(+) channels.	Lysine	97-100	potassium voltage-gated channel subfamily H member 2	Homo sapiens	207-211
2046459-0	1991	Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in conscious dogs.	Lysine	84-87	somatotropin	Canis lupus familiaris	27-41
11994459-5	2002	The association between PP2AA and CTLA-4 involves a conserved three-lysine motif in the juxtamembrane portion of the cytoplasmic tail of CTLA-4.	Lysine	68-74	protein phosphatase 2 phosphatase activator	Homo sapiens	24-29
2123846-5	1990	Increasing levels of dietary lysine resulted in increased ADG and improved feed conversion (quadratic, P less than .01) for pST-treated pigs.	Lysine	29-35	ADG	Sus scrofa	58-61
2123846-7	1990	Breakpoint analysis indicated that cumulative ADG and feed conversion were optimized at 1.19 and 1.22% lysine, respectively.	Lysine	103-109	ADG	Sus scrofa	46-49
21820402-4	2011	Ubiquitin containing lysine-48 was both necessary and sufficient to support UCP3 degradation, implying a requirement for polyubiquitylation at this residue.	Lysine	21-27	uncoupling protein 3	Homo sapiens	76-80
21820402-8	2011	We propose that matrix ATP and a high membrane potential are needed for UCP3 to be polyubiquitylated through lysine-48 of ubiquitin and exported to the cytosolic 26S proteasome, where it is de-ubiquitylated and degraded.	Lysine	109-115	uncoupling protein 3	Homo sapiens	72-76
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 1	Mus musculus	61-68
21778144-3	2011	The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and to regulate gene expression by binding methylated histone H3 lysine 9.	Lysine	233-239	chromobox 1	Mus musculus	90-94
11994459-5	2002	The association between PP2AA and CTLA-4 involves a conserved three-lysine motif in the juxtamembrane portion of the cytoplasmic tail of CTLA-4.	Lysine	68-74	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	34-40
11994459-5	2002	The association between PP2AA and CTLA-4 involves a conserved three-lysine motif in the juxtamembrane portion of the cytoplasmic tail of CTLA-4.	Lysine	68-74	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	137-143
2144594-6	1990	These results suggest that the NS1 lysine 405 of H-1 in its putative purine nucleotide-binding site is essential for viral DNA replication and that this domain may be involved in the regulation of the P38 promoter by an unknown mechanism.	Lysine	35-41	influenza virus NS1A binding protein	Homo sapiens	31-34
11994459-6	2002	Mutations of these lysine residues prevent the binding of PP2AA and enhance the inhibition of IL-2 gene transcription by CTLA-4, indicating that PP2A represses CTLA-4 function.	Lysine	19-25	protein phosphatase 2 phosphatase activator	Homo sapiens	58-63
11994459-6	2002	Mutations of these lysine residues prevent the binding of PP2AA and enhance the inhibition of IL-2 gene transcription by CTLA-4, indicating that PP2A represses CTLA-4 function.	Lysine	19-25	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	121-127
11994459-6	2002	Mutations of these lysine residues prevent the binding of PP2AA and enhance the inhibition of IL-2 gene transcription by CTLA-4, indicating that PP2A represses CTLA-4 function.	Lysine	19-25	protein phosphatase 2 phosphatase activator	Homo sapiens	58-62
11994459-6	2002	Mutations of these lysine residues prevent the binding of PP2AA and enhance the inhibition of IL-2 gene transcription by CTLA-4, indicating that PP2A represses CTLA-4 function.	Lysine	19-25	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	160-166
2252894-8	1990	For methyl methanethiosulfonate (MMTS) modified PBGS, the NMR spectra reflect the chemistry of an enzyme-bound Schiff base intermediate that is formed between C4 of ALA and an active-site lysine.	Lysine	188-194	aminolevulinate dehydratase	Homo sapiens	48-52
21895798-0	2011	The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.	Lysine	80-86	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	4-9
21895798-1	2011	In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and Lys21 homocitrate synthase (HCS) isoforms.	Lysine	61-67	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	115-120
11994459-7	2002	Our data imply that the lysine-rich motif in CTLA-4 may be used to identify small molecules that block its binding to PP2A and act as agonists for CTLA-4 function.	Lysine	24-30	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	45-51
21895798-1	2011	In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and Lys21 homocitrate synthase (HCS) isoforms.	Lysine	61-67	homocitrate synthase LYS21	Saccharomyces cerevisiae S288C	125-130
21895798-1	2011	In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and Lys21 homocitrate synthase (HCS) isoforms.	Lysine	69-72	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	115-120
11994459-7	2002	Our data imply that the lysine-rich motif in CTLA-4 may be used to identify small molecules that block its binding to PP2A and act as agonists for CTLA-4 function.	Lysine	24-30	protein phosphatase 2 phosphatase activator	Homo sapiens	118-122
21895798-1	2011	In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and Lys21 homocitrate synthase (HCS) isoforms.	Lysine	69-72	homocitrate synthase LYS21	Saccharomyces cerevisiae S288C	125-130
21895798-2	2011	Overexpression of Lys20 resulted in eightfold increased Lys, as well as 2-oxoglutarate pools, which were not attained by overexpressing Lys21 or other pathway enzymes (Lys1, Lys9 or Lys12).	Lysine	18-21	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	168-172
2374612-6	1990	This reveals an evolutionarily conserved core which corresponds precisely to the 180-residue DNA binding/activation domain determined for yeast TFIID, a near absolute conservation of component structural motifs (direct repeats, central basic core/lysine repeat, and sigma homology), providing further support for their functional importance, and a unique N-terminal structure that suggests involvement in species-specific regulatory factor interactions.	Lysine	247-253	TATA-box binding protein	Homo sapiens	144-149
21895798-2	2011	Overexpression of Lys20 resulted in eightfold increased Lys, as well as 2-oxoglutarate pools, which were not attained by overexpressing Lys21 or other pathway enzymes (Lys1, Lys9 or Lys12).	Lysine	18-21	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	174-178
11994459-7	2002	Our data imply that the lysine-rich motif in CTLA-4 may be used to identify small molecules that block its binding to PP2A and act as agonists for CTLA-4 function.	Lysine	24-30	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	147-153
21895798-4	2011	Therefore, the higher control of Lys20 over the Lys flux represents an exception to the dogma of higher pathway control by the strongest feedback-inhibited enzyme and points out to multi-site engineering (HCS isoforms and supply of precursors) to increase Lys synthesis.	Lysine	48-51	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	33-38
12011424-7	2002	The trimer-trimer interaction is further stabilized by a previously uncharacterized type of covalent cross-link between the side chains of a Met and a Lys residue of the alpha 1 and alpha 2 chains from opposite trimers, explaining previous findings of nonreducible cross-links in NC1.	Lysine	151-154	adrenoceptor alpha 1D	Homo sapiens	170-189
21968017-6	2011	Furthermore, we discovered that one of three lysine residues, Lys18, Lys214, or Lys230, was sumoylated in rpS3.	Lysine	45-51	ribosomal protein S3	Homo sapiens	106-110
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	Tax1 binding protein 1	Homo sapiens	10-17
21885437-6	2011	ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi.	Lysine	119-125	TNF receptor associated factor 3	Homo sapiens	86-91
2206400-3	1990	The derived amino acid sequence comprises the known amino acid sequence of SAP with an amino terminal representing a putative signal sequence; at the carboxyl terminus the sequence contains an additional lysine residue.	Lysine	204-210	caltrin	Bos taurus	75-78
2188100-3	1990	Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating GCN4 expression.	Lysine	35-41	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	81-85
2350348-3	1990	Glu at the 320th position of P-450(11 beta),aldo-1 was replaced with Lys in P-450(11 beta),aldo-2.	Lysine	69-72	aldolase, fructose-bisphosphate B	Rattus norvegicus	91-97
11861643-3	2002	We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity.	Lysine	114-117	monoamine oxidase A	Homo sapiens	61-72
11861643-3	2002	We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity.	Lysine	114-117	monoamine oxidase A	Homo sapiens	61-66
11976098-7	2002	The posttranslational modification of eIF-5A by a transfer of a 4-aminobutyl moiety from spermidine to conserved lysine 50 or 51, forming amino acid hypusine, is the only demonstrated specific function of polyamines in cell proliferation.	Lysine	113-119	eukaryotic translation initiation factor 5A	Homo sapiens	38-44
2160452-3	1990	The single cysteine residue in Ub-C48 can be converted into a lysine analog by modification with the sulfhydryl-specific reagent, aminoethyl-8 (N-(iodoethyl)trifluoroacetamide).	Lysine	62-68	CDK5 regulatory subunit associated protein 2	Homo sapiens	34-37
2160452-9	1990	The methylation of either Lys48 in ubiquitin or its S-aminoethylcysteine counterpart abolished its proteolytic function while the blockage of the remaining six lysines in Ub-(S-aminoethyl)C48 did not alter its competence.	Lysine	160-167	CDK5 regulatory subunit associated protein 2	Homo sapiens	188-191
2160459-9	1990	Identification of POMC-derived peptides demonstrated efficient processing of Lys-Arg and inefficient processing of Lys-Lys and Arg-Lys sites at both positions in the prohormone.	Lysine	77-80	proopiomelanocortin	Rattus norvegicus	18-22
21775461-7	2011	The lysine mutations reduced or abolished virus infectivity in plants and viral DNA accumulation in transient-replication assays, suggesting that the AL1-SCE1 interaction is required for viral DNA replication.	Lysine	4-10	ephrin A5	Homo sapiens	150-153
11971970-12	2002	As AR lysine residue mutations that abrogate acetylation correlate with enhanced binding of the N-CoR repressor in cultured cells, the conserved AR motif may directly or indirectly regulate ligand-dependent corepressor disengagement and, thereby, ligand-dependent trans activation.	Lysine	6-12	nuclear receptor corepressor 1	Homo sapiens	96-101
21820018-10	2011	Expectedly, site-directed mutagenesis of His321 in Lsc3 to Arg, Lys, Leu and Ser resulted in proteins with decreased catalytic activity, affinity for sucrose and polymerizing ability.	Lysine	64-67	glycoside hydrolase family 68 protein	Pseudomonas syringae pv. tomato str. DC3000	51-55
2122147-0	1990	Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme.	Lysine	13-19	carboxypeptidase E	Bos taurus	65-83
2122147-2	1990	In this study, CPH activity in the soluble and membrane fractions of enkephalin-containing bovine chromaffin granules was competitively inhibited by its products arginine and lysine.	Lysine	175-181	carboxypeptidase E	Bos taurus	15-18
11856731-2	2002	In particular, three amino acids that stabilize the transition state for the activation of tyrosine in B. stearothermophilus tyrosyl-tRNA synthetase (Cys-35, His-48, and Lys-233) are not present in the human enzyme.	Lysine	170-173	tyrosyl-tRNA synthetase 1	Homo sapiens	125-148
21832163-5	2011	This step was not affected, however, by inhibition of c-Jun phosphorylation, which instead blocked the binding of the late transcription factors, the recruitment of CREB-binding protein, and the acetylation of histone H3 at lysine 27.	Lysine	224-230	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
21775440-0	2011	Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus.	Lysine	0-6	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	87-92
2133944-5	1990	Amino acid analysis of dentine showed apparent differences among these groups in the degrees of hydroxylation of proline (Hyp/Pro + Hyp) and of lysine (Hyl/Lys + Hyl).	Lysine	144-150	megakaryocyte-associated tyrosine kinase	Homo sapiens	152-155
11939772-0	2002	Importance of lysine 125 for heparin binding and activation of antithrombin.	Lysine	14-20	serpin family C member 1	Homo sapiens	63-75
2360199-3	1990	Intravenous administration of the 5-HT2/5-HT1C antagonists ritanserin and LY 53857 in vivo blocked the facilitatory effects of 5-HT and DOM, but not norepinephrine (NE).	Lysine	74-76	5-hydroxytryptamine receptor 2C	Rattus norvegicus	40-46
21780790-1	2011	Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53.	Lysine	8-14	euchromatic histone lysine methyltransferase 2	Homo sapiens	33-36
12182908-1	2002	The amino terminal fragment (ATF, Ser(1)-Lys(135)) of urokinase-type plasminogen activator (uPA) containing an epidermal growth factor-like (EGF) and kringle domain is critically involved in some important functions of uPA, such as receptor binding and chemotactic activity.	Lysine	41-44	epidermal growth factor	Homo sapiens	111-145
21900893-5	2011	Here we show that SERCA2a is SUMOylated at lysines 480 and 585 and that this SUMOylation is essential for preserving SERCA2a ATPase activity and stability in mouse and human cells.	Lysine	43-50	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	18-25
21704546-4	2011	ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway.	Lysine	60-66	aldehyde dehydrogenase 7 family member A1	Homo sapiens	44-51
33769697-5	2021	Mechanistically, NEDD4L directly interacts with GP130 and mediates its Lys-27-linked ubiquitination and proteasomal degradation.	Lysine	71-74	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	17-23
12007809-4	2002	However, the primary sequence of the enzyme contains two Lys residues, Lys53 and Lys78, corresponding to the conserved motifs for SDR and AKR enzyme families, respectively, that may H-bond to Tyr49.	Lysine	57-60	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	130-133
33793773-7	2021	Mutagenesis of certain conserved lysines near the dimer interface restored the levels of Msh2 in the absence of Msh6, further supporting a dimer stabilization mechanism.	Lysine	33-40	mismatch repair ATPase MSH6	Saccharomyces cerevisiae S288C	112-116
21730290-6	2011	Interestingly, two of these histone mutants, H3 R49A and H3 V46A, reduce Set2-dependent methylation of lysine 36 of histone H3 and allow transcription initiation from cryptic intragenic promoters.	Lysine	103-109	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	73-77
21768309-0	2011	SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.	Lysine	33-39	KIT ligand	Homo sapiens	0-3
21768309-0	2011	SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.	Lysine	33-39	lysine demethylase 4A	Homo sapiens	101-106
21768309-2	2011	KDM4A is a histone demethylase that targets tri- and dimethylation marks on histone H3 lysines 9 and 36.	Lysine	87-94	lysine demethylase 4A	Homo sapiens	0-5
33782381-12	2021	Mechanistic research indicated that CREB and histone H4 lysine 20 methylation (H4K20me1, a downstream target of KMT5A) occupy the PTP1B promoter region.	Lysine	56-62	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	130-135
11923477-0	2002	Lysine 270 in the third intracellular domain of the oxytocin receptor is an important determinant for G alpha(q) coupling specificity.	Lysine	0-6	G protein subunit alpha q	Homo sapiens	102-112
33799951-1	2021	BACKGROUND: Lysine-specific demethylase 1A (KDM1A) plays an important role in epigenetic regulation in malignant tumors and promotes cancer invasion and metastasis by blocking the immune response and suppressing cancer surveillance activities.	Lysine	12-18	lysine demethylase 1A	Homo sapiens	44-49
11923477-6	2002	Mutation of a single lysine in the C-terminal OTR3i sequence to the corresponding V(2)R residue (valine) eliminated the enhanced ability of the V(2)R chimera to stimulate PLC but did not affect maximal adenylyl cyclase stimulation.	Lysine	21-27	heparan sulfate proteoglycan 2	Homo sapiens	171-174
21768309-7	2011	Changes in KDM4A abundance correlate with alterations in histone H3 lysine 9 and 36 methylation levels, and transcription of a KDM4A target gene, ASCL2.	Lysine	68-74	lysine demethylase 4A	Homo sapiens	11-16
11779867-5	2002	Interestingly, the single mutation K523R completely abolished modification of c-Myb with SUMO-1, suggesting that sumolation of Lys(523) is required for modification of other lysines in c-Myb.	Lysine	127-130	MYB proto-oncogene, transcription factor	Homo sapiens	78-83
21875933-4	2011	The pro-MSP cleavage sequence (Ser-Lys-Leu-Arg(483) Val(484)) closely matches the substrate recognition sequences of hepsin, a type II transmembrane serine protease, that is overexpressed in several cancers.	Lysine	35-38	hepsin	Homo sapiens	117-123
33589814-2	2021	We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the complex selectively ubiquitylates lysines 125, 127 and 129 in the flexible C-terminal tail of H2A in a fully human system.	Lysine	216-223	BRCA1 DNA repair associated	Homo sapiens	32-37
33589814-2	2021	We present the structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the complex selectively ubiquitylates lysines 125, 127 and 129 in the flexible C-terminal tail of H2A in a fully human system.	Lysine	216-223	BRCA1 associated RING domain 1	Homo sapiens	38-43
33768140-6	2021	USP7 enhanced the ubiquitination of Jumonji domain-containing protein D3 (JMJD3), elevated JMJD3-promoted growth of EC cells, and transcriptionally activated clusterin (CLU) expression at the promoter region via histone H3 lysine 27 tri-methyl (H3K27me3) demethylation, according to immunoprecipitation and ubiquitination assays.	Lysine	223-229	ubiquitin specific peptidase 7	Homo sapiens	0-4
11779867-5	2002	Interestingly, the single mutation K523R completely abolished modification of c-Myb with SUMO-1, suggesting that sumolation of Lys(523) is required for modification of other lysines in c-Myb.	Lysine	127-130	MYB proto-oncogene, transcription factor	Homo sapiens	185-190
21685393-5	2011	We find also that Lys-340 is a major ubiquitination site on Ste4, as pheromone-induced ubiquitination of the protein is prevented when this residue is mutated to an arginine.	Lysine	18-21	G protein subunit beta	Saccharomyces cerevisiae S288C	60-64
11779867-5	2002	Interestingly, the single mutation K523R completely abolished modification of c-Myb with SUMO-1, suggesting that sumolation of Lys(523) is required for modification of other lysines in c-Myb.	Lysine	174-181	MYB proto-oncogene, transcription factor	Homo sapiens	78-83
11884629-0	2002	Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD.	Lysine	36-42	DNA fragmentation factor, beta subunit	Mus musculus	131-134
32494966-6	2020	Vasohibin-1 was associated with Ly (P = 0.003) and pT (P = 0.037), whereas vasohibin-2 was associated with Ly (P < 0.001), V (P < 0.001) and pStage (P < 0.001).	Lysine	32-34	vasohibin 1	Homo sapiens	0-11
11876649-9	2002	However, when four additional lysines were introduced into RTA in a way that did not compromise the activity, structure, or stability of the toxin, degradation was significantly enhanced.	Lysine	30-37	MAS related GPR family member F	Homo sapiens	59-62
29137412-6	2017	Additionally, RNA immunoprecipitation (RIP) assays showed that SNHG15 epigenetically repressed the P15 and Kruppel-like factor 2 (KLF2) expression via binding to enhancer of zeste homolog 2 (EZH2), and chromatin immunoprecipitation assays (CHIP) assays demonstrated that EZH2 was capable of binding to promoter regions of P15 and KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	356-362	small nucleolar RNA host gene 15	Homo sapiens	63-69
21554249-5	2011	Lys(49) is an important functional residue within the ligand-binding groove of 14-3-3zeta with K49E 14-3-3zeta exhibiting markedly reduced binding to phosphorylated and non-phosphorylated ligands.	Lysine	0-3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	79-89
21554249-5	2011	Lys(49) is an important functional residue within the ligand-binding groove of 14-3-3zeta with K49E 14-3-3zeta exhibiting markedly reduced binding to phosphorylated and non-phosphorylated ligands.	Lysine	0-3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	100-110
25040736-6	2014	Furthermore, we demonstrated that SIRT1 is able to bind to the PAI-1 promoter, resulting in a decrease in the acetylation of histone H4 lysine 16 (H4K16) on the PAI-1 promoter region.	Lysine	136-142	sirtuin 1	Homo sapiens	34-39
11866428-7	2002	Our data do not exclude, however, that the histidine sequence simply mimics the lysine motif as a sorting signal, being recognised by and interacting with the same receptor subunit(s) in COP-I-coated vesicles.	Lysine	80-86	caspase recruitment domain family member 16	Homo sapiens	187-190
21383035-11	2011	2, using ADG and PUN, the estimated SID Lys requirement was 0.83%.	Lysine	40-43	ADG	Sus scrofa	9-12
11748245-9	2002	Interpretation of these results in light of the high-resolution structures of (Ca(2+))(4)-CaM, free and complexed with the CaM-binding domain of MLCK, indicates that a surface domain containing Lys(30) and Gly(40) and residues from the C-terminal domain is created upon binding to MLCK, formation of which is required for activation of MLCK.	Lysine	194-197	myosin light chain kinase	Homo sapiens	145-149
21383035-14	2011	Based on ADG, ADFI, and G:F, up to 0.23% supplemental Lys can be added along with supplemental Thr, Trp, and Met without negatively affecting growth performance; PUN was linearly decreased (P &lt; 0.001) by supplemental Lys.	Lysine	54-57	ADG	Sus scrofa	9-12
9920486-7	1999	Aspartate-49 and lysine-49 PLA2 group II variants showed a comparable cytolytic effect.	Lysine	17-23	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	27-31
34974206-2	2022	OXA and PMX were ionically complexed with lysine derivative of deoxycholic acid (DCK), and incorporated into nanoemulsions or colloidal dispersions, yielding OXA/DCK-NE and PMX/DCK-OP, respectively, to improve their oral bioavailabilities.	Lysine	42-48	deoxycytidine kinase	Mus musculus	81-84
21781306-5	2011	Using mass spectrophotometry and site-specific acetyl antibody, we identified Abl K921, located in the DNA binding domain, and conforming to one of the lysine residue in the consensus acetylation motif (KXXK--X3-5--SGS) is acetylated following DNA damage.	Lysine	152-158	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	78-81
21543325-3	2011	To understand the role of lysine residues within the C terminus of alpha(2)-antiplasmin, we systematically and sequentially mutated the C-terminal lysines, studied the effects on the rate of plasmin inhibition, and measured the binding affinity for plasmin via surface plasmon resonance.	Lysine	26-32	serpin family F member 2	Homo sapiens	67-87
11748245-9	2002	Interpretation of these results in light of the high-resolution structures of (Ca(2+))(4)-CaM, free and complexed with the CaM-binding domain of MLCK, indicates that a surface domain containing Lys(30) and Gly(40) and residues from the C-terminal domain is created upon binding to MLCK, formation of which is required for activation of MLCK.	Lysine	194-197	myosin light chain kinase	Homo sapiens	281-285
34974185-11	2022	The mutation of lysine 1413 within the PST-repeat of MDC1 deregulated MDC1 with or without damage.	Lysine	16-22	mediator of DNA damage checkpoint 1	Homo sapiens	53-57
11748245-9	2002	Interpretation of these results in light of the high-resolution structures of (Ca(2+))(4)-CaM, free and complexed with the CaM-binding domain of MLCK, indicates that a surface domain containing Lys(30) and Gly(40) and residues from the C-terminal domain is created upon binding to MLCK, formation of which is required for activation of MLCK.	Lysine	194-197	myosin light chain kinase	Homo sapiens	281-285
34974185-11	2022	The mutation of lysine 1413 within the PST-repeat of MDC1 deregulated MDC1 with or without damage.	Lysine	16-22	mediator of DNA damage checkpoint 1	Homo sapiens	70-74
11870779-7	2002	Furthermore, the result of sequencing suggested that the protein was an active form of hypusinated eIF-5A, because Lys 46 could be detected but not Lys 49, which is the site for hypusination.	Lysine	115-118	eukaryotic translation initiation factor 5A	Homo sapiens	99-105
34491605-2	2022	METHODS: We constructed novel unimolecular dual agonists of GLP-1R and glucagon receptor prepared by linking sEx-4 and native glucagon (GCG) via lysine or triazole (sEx4-GCG(K) and sEx4-GCG(T), respectively) and evaluated their anti-obesity and anti-diabetic efficacy in diabetic and obese mouse model.	Lysine	145-151	glucagon-like peptide 1 receptor	Mus musculus	60-66
21543325-5	2011	Using two independent methods, we also showed that the conserved internal lysine residues play a major role mediating binding of the C terminus of alpha(2)-antiplasmin to kringle domains of plasmin and in accelerating the rate of interaction between alpha(2)-antiplasmin and plasmin.	Lysine	74-80	serpin family F member 2	Homo sapiens	147-167
21543325-5	2011	Using two independent methods, we also showed that the conserved internal lysine residues play a major role mediating binding of the C terminus of alpha(2)-antiplasmin to kringle domains of plasmin and in accelerating the rate of interaction between alpha(2)-antiplasmin and plasmin.	Lysine	74-80	serpin family F member 2	Homo sapiens	250-270
11870779-7	2002	Furthermore, the result of sequencing suggested that the protein was an active form of hypusinated eIF-5A, because Lys 46 could be detected but not Lys 49, which is the site for hypusination.	Lysine	148-151	eukaryotic translation initiation factor 5A	Homo sapiens	99-105
21376121-10	2011	Lysine modifications also occur on the GATA4 molecule including acetylation and sumoylation.	Lysine	0-6	GATA binding protein 4	Homo sapiens	39-44
34593606-3	2022	Previously, we reported that histone modifiers regulating EMT could be therapeutic targets; therefore, in this study, we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for MPM.	Lysine	152-158	lysine demethylase 1A	Homo sapiens	183-187
11844113-2	2002	One mutant, mto3, accumulated remarkably high levels of free Met - more than 200-fold that observed for wild type - yet showed little or no difference in the concentrations of other protein amino-acids, such as aspartate, threonine and lysine.	Lysine	236-242	S-adenosylmethionine synthetase family protein	Arabidopsis thaliana	12-16
34593606-3	2022	Previously, we reported that histone modifiers regulating EMT could be therapeutic targets; therefore, in this study, we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for MPM.	Lysine	263-269	lysine demethylase 1A	Homo sapiens	183-187
34593606-3	2022	Previously, we reported that histone modifiers regulating EMT could be therapeutic targets; therefore, in this study, we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for MPM.	Lysine	263-269	lysine demethylase 1A	Homo sapiens	188-192
34593606-3	2022	Previously, we reported that histone modifiers regulating EMT could be therapeutic targets; therefore, in this study, we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for MPM.	Lysine	276-282	lysine demethylase 1A	Homo sapiens	183-187
34593606-3	2022	Previously, we reported that histone modifiers regulating EMT could be therapeutic targets; therefore, in this study, we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for MPM.	Lysine	276-282	lysine demethylase 1A	Homo sapiens	188-192
34808367-4	2022	Moreover, the histone H3 lysine 9 acetylation (H3K9ac) level of 11-beta hydroxysteroid dehydrogenase 2 (11beta-HSD2) and its expression in bone tissue of PDE offspring rats remained lower than the control before and after birth.	Lysine	25-31	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	104-115
21518757-0	2011	TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.	Lysine	23-26	TNF receptor associated factor 7	Homo sapiens	0-5
21518757-3	2011	TRAF7 promotes Lys-29-linked polyubiquitination of NEMO and p65 that results in lysosomal degradation of both proteins and altered activation.	Lysine	15-18	TNF receptor associated factor 7	Homo sapiens	0-5
21536658-6	2011	This process is dependent on the tyrosine kinase activity of the oncoproteins and is mediated primarily by lysine-dependent polyubiquitination of Dok-1.	Lysine	107-113	docking protein 1	Homo sapiens	146-151
11711550-7	2002	Lys(284), Lys(286), and Lys(287) in this domain are essential for the interaction of beta2-GPI with heparin.	Lysine	0-3	apolipoprotein H	Homo sapiens	85-94
21673141-4	2011	RSC is itself acetylated by Gcn5 on lysine 25 (K25) of its Rsc4 subunit, adjacent to two tandem bromodomains.	Lysine	36-42	Rsc4p	Saccharomyces cerevisiae S288C	59-63
34902970-2	2021	Herein, a smart nanocarrier (designated as mP-NPs-DNase/PTX) based on regulating tumor-associated NETs has been developed, which consists of a paclitaxel (PTX) prodrug nanoparticle core and a poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell.	Lysine	192-205	matrix metallopeptidase 9	Homo sapiens	232-258
34902970-2	2021	Herein, a smart nanocarrier (designated as mP-NPs-DNase/PTX) based on regulating tumor-associated NETs has been developed, which consists of a paclitaxel (PTX) prodrug nanoparticle core and a poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell.	Lysine	192-205	matrix metallopeptidase 9	Homo sapiens	260-265
11711550-7	2002	Lys(284), Lys(286), and Lys(287) in this domain are essential for the interaction of beta2-GPI with heparin.	Lysine	10-13	apolipoprotein H	Homo sapiens	85-94
11711550-7	2002	Lys(284), Lys(286), and Lys(287) in this domain are essential for the interaction of beta2-GPI with heparin.	Lysine	10-13	apolipoprotein H	Homo sapiens	85-94
34937916-1	2021	Enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine 27 (H3K27me3), which is a repressive marker at the transcriptional level.	Lysine	169-175	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
11711550-10	2002	Surprisingly, heparin at concentrations that can be achieved in vivo during anticoagulation therapy greatly enhances the plasmin-mediated cleavage of the Lys(317)-Thr(318) site in beta2-GPI.	Lysine	154-157	apolipoprotein H	Homo sapiens	180-189
34937916-1	2021	Enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine 27 (H3K27me3), which is a repressive marker at the transcriptional level.	Lysine	169-175	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
21693764-5	2011	Furthermore, proteasomal inhibition resulted in the accumulation of conjugated forms of all SUMO paralogs in insoluble protein inclusions and in the accumulation on SUMO-2 substrates of lysine-63-linked polyubiquitin chains, which are not thought to serve as signals for proteasome-mediated degradation.	Lysine	186-192	small ubiquitin like modifier 2	Homo sapiens	165-171
11802715-5	2002	We demonstrate that recombinant MSP exhibits a broad specificity for cleavage after arginine but not lysine residues, with kinetic characteristics intermediate between trypsin and pancreatic kallikrein.	Lysine	101-107	transmembrane serine protease 13	Homo sapiens	32-35
21660059-1	2011	Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4.	Lysine	144-150	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	0-5
34953958-2	2022	p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 (H3K27ac) and is activated during fibrosis.	Lysine	48-54	E1A binding protein p300	Mus musculus	0-4
11802715-6	2002	We show that the pro form of MSP does not self-activate but, rather, requires cleavage after lysine, indicating that mature active MSP is regulated by a distinct protease.	Lysine	93-99	transmembrane serine protease 13	Homo sapiens	29-32
11752412-4	2002	We report here the purification, molecular identification, and genetic and biochemical characterization of the Set1 protein complex that is necessary for methylation of histone H3 at lysine residue 4 in Saccharomyces cerevisiae.	Lysine	183-189	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	111-115
34930462-1	2021	BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit the expression of downstream tumor-suppressing genes.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	12-39
34930462-1	2021	BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit the expression of downstream tumor-suppressing genes.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	41-45
20656950-10	2011	Purified PcRtt109 had the ability to acetylate lysine-56 of histone H3, similar to the ability of Schizosaccharomyces pombe Rtt109 protein.	Lysine	47-53	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	11-17
11792185-2	2002	We have synthesized a bifunctional vinyl sulfone-cysteineamido derivative of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) that can be conjugated to the sulfhydryls of mildly reduced recombinant antibody (chimeric anti-CEA antibody cT84.66) at pH 7 or to the amino groups of lysine residues at pH 9.	Lysine	293-299	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	237-240
21586903-3	2011	In addition to having roles in DNA replication initiation, the human Origin Recognition Complex (ORC) binds along with ORC-associated proteins ORCA/ LRWD1 to prominent transcriptional repressive lysine methylation marks and localizes to HP1-containing heterochromatic structures.	Lysine	195-201	leucine rich repeats and WD repeat domain containing 1	Homo sapiens	143-147
21586903-3	2011	In addition to having roles in DNA replication initiation, the human Origin Recognition Complex (ORC) binds along with ORC-associated proteins ORCA/ LRWD1 to prominent transcriptional repressive lysine methylation marks and localizes to HP1-containing heterochromatic structures.	Lysine	195-201	leucine rich repeats and WD repeat domain containing 1	Homo sapiens	149-154
21454709-0	2011	The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.	Lysine	83-89	sirtuin 1	Homo sapiens	33-38
34289376-2	2021	GAS41 is a dimeric protein that contains the YEATS domain, which is involved in the recognition of lysine-acylated histones.	Lysine	99-105	YEATS domain containing 4	Homo sapiens	0-5
34289376-4	2021	These inhibitors bind to GAS41 YEATS domain in a channel constituting a recognition site for acylated lysine on histone proteins.	Lysine	102-108	YEATS domain containing 4	Homo sapiens	25-30
21454709-0	2011	The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.	Lysine	83-89	BCL2 associated transcription factor 1	Homo sapiens	108-114
12900547-4	2002	At PGK1 and HPRT, chromatin on the active X chromosome reveals H3 lysine 4 methylation and acetylation of histones H3 and H4.	Lysine	66-72	phosphoglycerate kinase 1	Homo sapiens	3-7
21454709-3	2011	Sirt1-null T cells have increased acetylation of the histone 3 lysine 56 residue (H3K56) at the bclaf1 promoter, as well as increasing Bclaf1 transcription.	Lysine	63-69	sirtuin 1	Homo sapiens	0-5
21454709-3	2011	Sirt1-null T cells have increased acetylation of the histone 3 lysine 56 residue (H3K56) at the bclaf1 promoter, as well as increasing Bclaf1 transcription.	Lysine	63-69	BCL2 associated transcription factor 1	Homo sapiens	96-102
34747456-1	2021	PRDM9 is a DNA-binding histone methyltransferase that designates and activates recombination hotspots in mammals by locally trimethylating lysines 4 and 36 of histone H3.	Lysine	139-146	PR domain containing 9	Mus musculus	0-5
34943981-6	2021	Chromatin Immunoprecipitation-Sequencing (ChIP-Seq) analysis of SC isolated from tributyrin treated pigs showed a global reduction of the tri-methylation of lysine 27 of histone H3 (H3K27me3) repressive chromatin mark.	Lysine	157-163	LOC100622412	Sus scrofa	170-180
21367748-3	2011	EZH2, together with SUZ12 and EED, forms the polycomb repressive complex 2 (PRC2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3).	Lysine	128-134	embryonic ectoderm development	Homo sapiens	30-33
12900547-6	2002	On the expressed allele of XIST (on the inactive X chromosome), we found that H3 acetylation is confined to the promoter, whereas H3 lysine 4 methylation and H4 acetylation are present along the entire gene.	Lysine	133-139	X inactive specific transcript	Homo sapiens	27-31
34880421-6	2021	Once freed from PEPD, p53 mutants undergo multiple posttranslational modifications, especially lysine 373 acetylation, which cause them to refold and regain tumor suppressor activities that are typically displayed by p53.	Lysine	95-101	peptidase D	Homo sapiens	16-20
12900547-7	2002	On the repressed XIST allele, in contrast, the promoter and gene exhibit H3 lysine 9 methylation.	Lysine	76-82	X inactive specific transcript	Homo sapiens	17-21
12900547-8	2002	At only 1.5 kb upstream of the XIST gene, chromatin on the inactive X chromosome has strongly reduced levels of H4 acetylation and is marked by both H3 lysine 9 and H3 lysine 4 methylation.	Lysine	152-158	X inactive specific transcript	Homo sapiens	31-35
34644545-3	2021	TRIP12 interacts with and ubiquitinates GCase at lysine 293 to control its degradation via ubiquitin proteasomal degradation.	Lysine	49-55	thyroid hormone receptor interactor 12	Homo sapiens	0-6
12900547-8	2002	At only 1.5 kb upstream of the XIST gene, chromatin on the inactive X chromosome has strongly reduced levels of H4 acetylation and is marked by both H3 lysine 9 and H3 lysine 4 methylation.	Lysine	168-174	X inactive specific transcript	Homo sapiens	31-35
20569305-5	2002	In addition, complementation analysis revealed AAT1-dependent transport for lysine.	Lysine	76-82	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	47-51
34942999-0	2021	Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.	Lysine	18-24	nucleoporin 62	Mus musculus	66-69
21446907-3	2011	MMP-9 enzyme recognizes a peptide sequence Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys and cleaves the peptide into two parts.	Lysine	43-46	matrix metallopeptidase 9	Homo sapiens	0-5
21446907-3	2011	MMP-9 enzyme recognizes a peptide sequence Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys and cleaves the peptide into two parts.	Lysine	75-78	matrix metallopeptidase 9	Homo sapiens	0-5
21357426-5	2011	Moreover, p300 interacts with the C terminus of Pax5 and acetylates multiple lysine residues within the paired box DNA binding domain of Pax5.	Lysine	77-83	paired box 5	Homo sapiens	48-52
21357426-5	2011	Moreover, p300 interacts with the C terminus of Pax5 and acetylates multiple lysine residues within the paired box DNA binding domain of Pax5.	Lysine	77-83	paired box 5	Homo sapiens	137-141
20569305-6	2002	Using Xenopus oocytes as expression system, AAT1p-dependent symport of protons with a broad spectrum of amino acids was observed, with the highest activities obtained with histidine and lysine.	Lysine	186-192	aspartate transaminase AAT1	Saccharomyces cerevisiae S288C	44-49
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	paired box 5	Homo sapiens	60-64
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	paired box 5	Homo sapiens	102-106
11738469-1	2002	Transglutaminase-catalyzed epsilon(gamma-glutamyl)lysine cross-links exist in Alzheimer"s disease (AD) paired helical filament (PHF) tau protein but not normal soluble tau.	Lysine	50-56	microtubule associated protein tau	Homo sapiens	103-136
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	paired box 5	Homo sapiens	102-106
21357426-6	2011	Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK293 cells and prevent Pax5 to activate endogenous Cd19 and Blnk expression in Pax5(-/-) murine pro B cells.	Lysine	13-19	paired box 5	Homo sapiens	102-106
34755724-2	2021	Here, a model LLPS system coupled with a sequential glycolytic enzymatic reaction was developed to reproduce the dynamic control of liquid droplets; (i) the droplets, which consist of poly-L-lysine and nucleotides, compartmentalize two different enzymes (hexokinase and glucose-6-phosphate dehydrogenase) individually, accelerating the overall reaction, and (ii) each enzymatic reaction triggers the formation, dissolution and long-term retention of the droplets by converting the scaffold nucleotides.	Lysine	184-197	glucose-6-phosphate dehydrogenase	Homo sapiens	270-303
34344022-2	2021	Enhancer of homolog 2 (EZH2), is a histone methyltransferase that methylates lysine residue 27, and thereby, suppresses gene expression.	Lysine	77-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	23-27
11738469-1	2002	Transglutaminase-catalyzed epsilon(gamma-glutamyl)lysine cross-links exist in Alzheimer"s disease (AD) paired helical filament (PHF) tau protein but not normal soluble tau.	Lysine	50-56	microtubule associated protein tau	Homo sapiens	133-136
21464287-3	2011	We show that AKAP79 dimerizes, and we demonstrate that, upon addition of a lysine-reactive cross-linker, parallel homomeric dimers are stabilized through K328-K328 and K333-K333 cross-links.	Lysine	75-81	A-kinase anchoring protein 5	Homo sapiens	13-19
11738469-5	2002	Immunoaffinity purification and immunoblotting experiments demonstrated that PHF tau contains epsilon(gamma-glutamyl)lysine bonds in parietal and frontal cortex in AD.	Lysine	117-123	microtubule associated protein tau	Homo sapiens	77-84
11738469-6	2002	In control cases with NFT present in the entorhinal cortex and hippocampus, indicative of Braak and Braak stage II, epsilon(gamma-glutamyl)lysine bonds were present in PHF tau in parietal and frontal cortex, despite the lack of microscopically detectable NFT or senile plaques in these cortical regions.	Lysine	139-145	microtubule associated protein tau	Homo sapiens	168-175
21498567-3	2011	Among the identified HKMTs in mammals, G9a and GLP are the primary enzymes for mono- and dimethylation at Lys 9 of histone H3 (H3K9me1 and H3K9me2), and exist predominantly as a G9a-GLP heteromeric complex that appears to be a functional H3K9 methyltransferase in vivo.	Lysine	106-109	euchromatic histone lysine methyltransferase 2	Homo sapiens	39-42
34927013-1	2021	Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	31-35
11679580-7	2001	Neuritogenesis is also impaired by alpha(2)-plasmin inhibitor, antibodies directed against t-PA and u-PA, and epsilon-aminocaproic acid, a lysine analog that inhibits Plg activation and the binding of Plg to Ann-II.	Lysine	139-145	plasminogen	Rattus norvegicus	167-170
34927013-1	2021	Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	39-44
34738714-5	2022	Mechanistically, PELI1 mediated the lysine 48 (Lys48)-linked polyubiquitination and degradation of NF-kappaB-inducing kinase (NIK; also known as MAP3K14), the master kinase of the noncanonical NF-kappaB pathway, thereby inhibiting IR-induced activation of the noncanonical NF-kappaB signaling pathway during radiotherapy.	Lysine	36-42	pellino E3 ubiquitin protein ligase 1	Homo sapiens	17-22
34088983-2	2021	The ubiquitin ligases RNF20 and RNF40 mediate the monoubiquitination of histone H2B at lysine 120 (H2Bub1) and were shown to play context-dependent roles in the development of inflammation.	Lysine	87-93	ring finger protein 40	Mus musculus	32-37
21330366-3	2011	Additionally, a lysine-less beta2AR (0K-beta2AR) that is deficient in ubiquitination and degradation is not sorted to lysosomes unlike the WT beta2AR, which is sorted to lysosomes.	Lysine	16-22	adrenoceptor beta 2	Homo sapiens	28-35
21330366-3	2011	Additionally, a lysine-less beta2AR (0K-beta2AR) that is deficient in ubiquitination and degradation is not sorted to lysosomes unlike the WT beta2AR, which is sorted to lysosomes.	Lysine	16-22	adrenoceptor beta 2	Homo sapiens	37-47
21330366-3	2011	Additionally, a lysine-less beta2AR (0K-beta2AR) that is deficient in ubiquitination and degradation is not sorted to lysosomes unlike the WT beta2AR, which is sorted to lysosomes.	Lysine	16-22	adrenoceptor beta 2	Homo sapiens	40-47
11679580-7	2001	Neuritogenesis is also impaired by alpha(2)-plasmin inhibitor, antibodies directed against t-PA and u-PA, and epsilon-aminocaproic acid, a lysine analog that inhibits Plg activation and the binding of Plg to Ann-II.	Lysine	139-145	plasminogen	Rattus norvegicus	201-204
11747809-6	2001	We also identify a unique "hotspot" of H3 Lys-9 methylation 5" to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation.	Lysine	42-45	X inactive specific transcript	Homo sapiens	129-133
21330366-10	2011	We identified ubiquitinated lysines in the third intracellular loop (Lys-263 and Lys-270) and in the carboxyl tail (Lys-348, Lys-372, and Lys-375) of the beta2AR.	Lysine	28-35	adrenoceptor beta 2	Homo sapiens	154-161
34600894-2	2021	The present study aimed to determine the role of 3-deazaneplanocin A (DZNep), which inhibits the transcription of Ezh2 by reducing the trimethylation of histone 3 lysine 27 (H3K27me3), in a retinal ganglion cell (RGC) degeneration model.	Lysine	163-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	114-118
11747809-6	2001	We also identify a unique "hotspot" of H3 Lys-9 methylation 5" to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation.	Lysine	201-204	X inactive specific transcript	Homo sapiens	66-70
11747809-6	2001	We also identify a unique "hotspot" of H3 Lys-9 methylation 5" to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation.	Lysine	201-204	X inactive specific transcript	Homo sapiens	129-133
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Lysine	325-328	serpin family E member 1	Homo sapiens	163-168
34453478-0	2021	In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC).	Lysine	26-32	lysine demethylase 1A	Homo sapiens	55-60
34453478-0	2021	In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC).	Lysine	26-32	lysine demethylase 1A	Homo sapiens	61-65
21269891-2	2011	Monoubiquitination (PCNA-Ub) at lysine residue 164 (K164) stimulates error-prone translesion synthesis (TLS), Rad5-dependent polyubiquitination (PCNA-Ub(n)) stimulates error-free template switching (TS).	Lysine	32-38	proliferating cell nuclear antigen	Mus musculus	20-24
21269891-2	2011	Monoubiquitination (PCNA-Ub) at lysine residue 164 (K164) stimulates error-prone translesion synthesis (TLS), Rad5-dependent polyubiquitination (PCNA-Ub(n)) stimulates error-free template switching (TS).	Lysine	32-38	proliferating cell nuclear antigen	Mus musculus	145-149
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Lysine	325-328	serpin family E member 1	Homo sapiens	238-243
34694864-0	2021	GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.	Lysine	113-119	GATA binding protein 3	Homo sapiens	0-5
11686577-6	2001	A post-translational pathway involves: 1) metabolic conversion of Hcy to thiolactone by methionyl-tRNAsynthetase (MetRS), and 2) acylation of protein lysine residues by Hcy thiolactone.	Lysine	150-156	methionyl-tRNA synthetase 1	Homo sapiens	114-119
34694864-0	2021	GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection.	Lysine	113-119	GATA binding protein 3	Homo sapiens	7-29
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	83-126
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	128-132
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	135-139
34166767-3	2021	Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2.	Lysine	57-60	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	308-312
34685453-1	2021	G9a is a lysine methyltransferase catalyzing the majority of histone H3 mono- and dimethylation at Lys-9 (H3K9), responsible for transcriptional repression events in euchromatin.	Lysine	99-102	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
21176092-10	2011	Furthermore, Sirt1 and HNF-1alpha co-localize on two HNF-1alpha binding sites on the Crp promoter, leading to decreased acetylation of lysine 16 of histone H4 at these sites only in response to nutrient restriction.	Lysine	135-141	sirtuin 1	Homo sapiens	13-18
21237246-1	2011	Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates.	Lysine	63-69	arginyl aminopeptidase	Homo sapiens	0-16
21237246-1	2011	Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates.	Lysine	63-69	arginyl aminopeptidase	Homo sapiens	18-22
34685453-2	2021	G9a has been shown to methylate various lysine residues of non-histone proteins and acts as a coactivator for several transcription factors.	Lysine	40-46	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
11728629-0	2001	Protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67.	Lysine	138-144	methionyl aminopeptidase 2	Rattus norvegicus	162-165
34437902-2	2021	The amino sugar epimerase N-acetylmannosamine-6-phosphate 2-epimerase (NanE) has been proposed to use a deprotonation-reprotonation mechanism, with an essential catalytic lysine required for both steps.	Lysine	171-177	AT695_RS02205	Staphylococcus aureus	26-69
21524351-3	2011	Approximately 75% of PEP-1-MsrA fusion protein was truncated in the N-terminal region of MsrA between Lys-27 and Val-28 during expression in Escherichia coli and purification.	Lysine	102-105	methionine sulfoxide reductase A	Homo sapiens	27-31
21524351-3	2011	Approximately 75% of PEP-1-MsrA fusion protein was truncated in the N-terminal region of MsrA between Lys-27 and Val-28 during expression in Escherichia coli and purification.	Lysine	102-105	methionine sulfoxide reductase A	Homo sapiens	89-93
11728629-6	2001	At the N-terminus of p67, there are two unique domains: a lysine-rich domain I with the sequence (36)KKKRRKKKK(44), and an acidic residue-rich domain with the sequence (77)EEKEKDDDDEDGDGD(91).	Lysine	58-64	methionyl aminopeptidase 2	Rattus norvegicus	21-24
11728629-7	2001	Substitution of lysine-rich domain I with (36)NMKSGNKTQ(44) in rat recombinant p67 resulted in the inhibition of its POEP activity, and substitution of the acidic residue-rich domain with (77)QNIQKALEPEAGDGA(91), resulted in no inhibition of POEP activity in KRC-7 cells.	Lysine	16-22	methionyl aminopeptidase 2	Rattus norvegicus	79-82
34480900-8	2021	We found that Abf2p, the principal component of mt-nucleoids responsible for compacting mtDNA in S. cerevisiae, can be succinylated in vivo on at least thirteen lysine residues.	Lysine	161-167	DNA-binding protein ABF2	Saccharomyces cerevisiae S288C	14-19
11728629-8	2001	Taken together, our data suggest that protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67.	Lysine	176-182	methionyl aminopeptidase 2	Rattus norvegicus	200-203
11418618-3	2001	For a beta(2)-microglobulin variant cleaved at lysine 58, we show using capillary electrophoresis that two conformers spontaneously exist in aqueous buffers at neutral pH.	Lysine	47-53	beta-2-microglobulin	Homo sapiens	6-27
34795154-3	2021	The alignment of amino acid sequences revealed that 5 Lys residues (K20, K26, K44, K139, and K166) of the 13 Lys residues within NS5A (genotype 2a, JFH1 strain) were conserved compared to those of HCV (genotype 1b, Con1 strain).	Lysine	54-57	keratin 26	Homo sapiens	73-76
34795154-3	2021	The alignment of amino acid sequences revealed that 5 Lys residues (K20, K26, K44, K139, and K166) of the 13 Lys residues within NS5A (genotype 2a, JFH1 strain) were conserved compared to those of HCV (genotype 1b, Con1 strain).	Lysine	109-112	keratin 26	Homo sapiens	73-76
20412396-3	2011	Among all enzymatic functions, lysyl-oxidase enzymatic activity, which is crucial in the formation of the lysine-derived cross-links in collagen and elastin, is the most sensitive to the copper transport alterations.	Lysine	106-112	elastin	Homo sapiens	149-156
21282469-3	2011	We first show that PTIP is recruited to a Pax5 binding site to promote histone H3 lysine 4 (H3K4) methylation.	Lysine	82-88	paired box 5	Homo sapiens	42-46
21256156-1	2011	Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has emerged as an important oncogene that is overexpressed in all cancers analyzed so far.	Lysine	130-136	CEA cell adhesion molecule 1	Homo sapiens	142-149
11460167-5	2001	This Ubc complex, together with TRAF6, catalyses the formation of a Lys 63 (K63)-linked polyubiquitin chain that mediates IKK activation through a unique proteasome-independent mechanism.	Lysine	68-71	TNF receptor associated factor 6	Homo sapiens	32-37
34382399-10	2021	OMG ameliorated the acetylation of p53 at lysine 382 (K382) and subsequent activation of p21 via inhibition of PAI-1.	Lysine	42-48	KRAS proto-oncogene, GTPase	Rattus norvegicus	89-92
11732685-0	2001	Mutation of lysine residues of the 78-kDa gastrin-binding protein reduces gastrin binding.	Lysine	12-18	gastrin	Homo sapiens	42-49
21209078-9	2011	Mutation analysis of AtMCP2d revealed that cleavage after Lys-225, which is a highly conserved residue among the six Arabidopsis type II MCPs, is critical for the catalytic activation by Ca(2+), and we demonstrate that this residue is essential for AtMCP2d activation of H(2)O(2)-induced cell death in yeast.	Lysine	58-61	metacaspase 4	Arabidopsis thaliana	21-28
11732685-3	2001	In order to define the gastrin-binding sites of the GBP in greater detail, we have constructed a truncation mutant lacking residues 221-318 of the N-terminal domain and a series of point mutants in which the lysine residues in the first 220 residues of the N-terminal domain were mutated to arginine residues.	Lysine	208-214	gastrin	Homo sapiens	23-30
21209078-9	2011	Mutation analysis of AtMCP2d revealed that cleavage after Lys-225, which is a highly conserved residue among the six Arabidopsis type II MCPs, is critical for the catalytic activation by Ca(2+), and we demonstrate that this residue is essential for AtMCP2d activation of H(2)O(2)-induced cell death in yeast.	Lysine	58-61	metacaspase 4	Arabidopsis thaliana	249-256
34415726-4	2021	Here, we describe our efforts to target the chromodomain of M-phase phosphoprotein 8 (MPP8), a member of the human silencing hub (HUSH) complex and a histone 3 lysine 9 trimethyl (H3K9me3) reader that is vital for heterochromatin formation and has specific roles in cancer metastasis.	Lysine	160-166	M-phase phosphoprotein 8	Homo sapiens	60-84
34415726-4	2021	Here, we describe our efforts to target the chromodomain of M-phase phosphoprotein 8 (MPP8), a member of the human silencing hub (HUSH) complex and a histone 3 lysine 9 trimethyl (H3K9me3) reader that is vital for heterochromatin formation and has specific roles in cancer metastasis.	Lysine	160-166	M-phase phosphoprotein 8	Homo sapiens	86-90
11369796-3	2001	The pK(a) values of lysines (K) at positions 143 and 146 in the LDLR-binding region in DMPC-associated 22-kDa apoE fragments were 9.4 and 9.9 in apoE2, 9.5 and 9.2 in apoE3, and 9.9 and 9.4 in apoE4, respectively.	Lysine	20-27	low density lipoprotein receptor	Homo sapiens	64-68
34214583-1	2021	SIRT1 (sirtuin 1, a member of histone deacetylase III family) is responsible for deacetylation of lysine in histones and the conservation of DNA in the state of transcriptionally inactive heterochromatin.	Lysine	98-104	sirtuin 1	Homo sapiens	0-5
34214583-1	2021	SIRT1 (sirtuin 1, a member of histone deacetylase III family) is responsible for deacetylation of lysine in histones and the conservation of DNA in the state of transcriptionally inactive heterochromatin.	Lysine	98-104	sirtuin 1	Homo sapiens	7-16
21282102-6	2011	Chromatin immunoprecipitation analysis indicates that this KLF6 transcriptional activation was associated with increased histone H3 acetylation and histone H3 lysine 4 trimethylation occupancy at the promoter region.	Lysine	159-165	Kruppel like factor 6	Homo sapiens	59-63
11388408-8	2001	The observed sequence of the N-terminal amino acids, Glu-Glu-Gln-Asn-Lys, of the purified CSF-neurosin was identical to the sequence of N-terminal of the pro-enzyme form, which is presumed to have no enzyme activity.	Lysine	69-72	colony stimulating factor 2	Homo sapiens	90-102
21430779-6	2011	SETDB1, an enzyme that methylates histone H3 on lysine 9 (H3K9), was found to accelerate melanoma formation significantly in zebrafish.	Lysine	48-54	SET domain bifurcated histone lysine methyltransferase 1a	Danio rerio	0-6
34448811-5	2021	KDM5A is a demethylase of histone H3 lysine 4 di- and tri-methylations (H3K4me2/3) and a transcription corepressor.	Lysine	37-43	lysine demethylase 5A	Homo sapiens	0-5
11320308-0	2001	Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.	Lysine	69-72	Rho GDP dissociation inhibitor alpha	Homo sapiens	117-123
34572752-5	2021	LOX-sensitive peptides (LS-peptides) contain lysine residues that are converted to allysine in the presence of LOX, which is highly reactive and binds to adjacent allysine, resulting in the aggregation of the AuNPs.	Lysine	45-51	lysyl oxidase	Homo sapiens	0-3
34572752-5	2021	LOX-sensitive peptides (LS-peptides) contain lysine residues that are converted to allysine in the presence of LOX, which is highly reactive and binds to adjacent allysine, resulting in the aggregation of the AuNPs.	Lysine	45-51	lysyl oxidase	Homo sapiens	111-114
34246782-4	2021	Lysine-specific demethylase 1 (LSD1), binding to 3" domain of HOTAIR, specifically removes mono- and di-methyl marks from H3 lysine 4 (H3K4) and plays key roles during carcinogenesis.	Lysine	125-131	lysine demethylase 1A	Homo sapiens	0-29
21464960-5	2011	PLG efficiently bound to spores in a lysine- and exosporium-dependent manner.	Lysine	37-43	plasminogen	Oryctolagus cuniculus	0-3
21464980-1	2011	BACKGROUND: Histone demethylase, JMJD2A, specifically recognizes and binds to methylated lysine residues at histone H3 and H4 tails (especially trimethylated H3K4 (H3K4me3), trimethylated H3K9 (H3K9me3) and di,trimethylated H4K20 (H4K20me2, H4K20me3)) via its tandem tudor domains.	Lysine	89-95	lysine demethylase 4A	Homo sapiens	33-39
11320308-4	2001	This paper reports the results of experiments with an important cytosolic regulator of GTPases, human RhoGDI, in which lysine residues were systematically mutated to alanines.	Lysine	119-125	Rho GDP dissociation inhibitor alpha	Homo sapiens	102-108
21233208-5	2011	LC-MS/MS analysis and co-immunoprecipitation revealed that the target protein of DB16-1 was human LYRIC (lysine-rich CEACAM1 co-isolated).	Lysine	105-111	CEA cell adhesion molecule 1	Homo sapiens	117-124
34246782-4	2021	Lysine-specific demethylase 1 (LSD1), binding to 3" domain of HOTAIR, specifically removes mono- and di-methyl marks from H3 lysine 4 (H3K4) and plays key roles during carcinogenesis.	Lysine	125-131	lysine demethylase 1A	Homo sapiens	31-35
11325856-4	2001	eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue.	Lysine	149-155	eukaryotic translation initiation factor 5A	Homo sapiens	0-6
34408138-2	2021	The RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K)13/15 (mUb-H2A), forming a binding module for DNA repair proteins.	Lysine	83-89	ring finger protein 168	Mus musculus	4-10
34408138-2	2021	The RNF168 E3 ubiquitin ligase catalyzes the mono-ubiquitination of histone H2A at lysine (K)13/15 (mUb-H2A), forming a binding module for DNA repair proteins.	Lysine	83-89	H2A.B variant histone 2	Mus musculus	68-79
21386094-4	2011	Here, we report that monoubiquitination of lysine-147 in the guanine nucleotide-binding motif of wild-type K-Ras could lead to enhanced GTP loading.	Lysine	43-49	KRAS proto-oncogene, GTPase	Homo sapiens	107-112
11325856-4	2001	eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue.	Lysine	149-155	eukaryotic translation initiation factor 5A	Homo sapiens	56-62
21318388-7	2011	Catalytic constants (k(cat)) of mutant enzymes were 45-149% of hTS, with the lysine mutant (R163K) exhibiting the highest k(cat).	Lysine	77-83	APC down-regulated 1	Homo sapiens	63-66
11374556-3	2001	In Trial 1 (n = 30), administration via the reticular groove of 0 to 64 g/d of lysine as L-lysine monohydrochloride resulted in a linear decrease in DMI and N utilization efficiency, with notably lower values at 64 g/d, although ADG and gain/feed ratio were not affected.	Lysine	79-85	ADG	Bos taurus	229-232
21318388-11	2011	The data indicate that the enzyme with arginine at the position corresponding to 163 (hTS) evolved after the divergence of prosimians and simians and that substitution of lysine by arginine confers unique structural and functional properties to the enzyme expressed in simian primates.	Lysine	171-177	APC down-regulated 1	Homo sapiens	86-89
20972224-6	2011	UV radiation induces the acetylation of histone H3 lysine 9 (H3K9) and this requires both GCN5 and E2F1.	Lysine	51-57	lysine acetyltransferase 2A	Homo sapiens	90-94
34217716-10	2021	Acetylation of lysine at positions K298, K302 and K326 of C/EBP-alpha promotes its binding to Beclin1.	Lysine	15-21	beclin 1	Homo sapiens	94-101
34385569-8	2021	Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1alpha promoter region and thus inhibited the methylation of HIF1alpha to promote HIF1alpha expression, thus upregulating DDIT4 and activating the mTOR signaling pathway.	Lysine	62-68	lysine demethylase 4A	Homo sapiens	17-22
11306718-1	2001	Membrane-bound carboxypeptidase D (CPD) is a B-type carboxypeptidase that specifically cleaves C-terminal Arg or Lys from peptides and proteins.	Lysine	113-116	carboxypeptidase D	Homo sapiens	15-33
34321663-0	2021	BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.	Lysine	16-22	BRCA1 associated RING domain 1	Homo sapiens	0-5
34321663-5	2021	We further show that BARD1 binds nucleosomes through multivalent interactions: coordinated binding of H2AK15ub and unmethylated H4 lysine 20 by its adjacent BUDR and ankyrin repeat domains, respectively, provides high-affinity recognition of DNA lesions in replicated chromatin and promotes the homologous recombination activities of the BRCA1-BARD1 complex.	Lysine	131-137	BRCA1 associated RING domain 1	Homo sapiens	21-26
21437264-4	2011	Here, we show that the Caenorhabditis elegans four MBT domain protein LIN-61, in contrast to other MBT repeat factors, specifically interacts with histone H3 when methylated on lysine 9, displaying a strong preference for di- and trimethylated states (H3K9me2/3).	Lysine	177-183	Protein lin-61	Caenorhabditis elegans	70-76
21131586-3	2011	We found that tumor necrosis factor-alpha (TNF-alpha) SUMOylated MK2 at lysine (K)-339 affected EC actin filament organization and migration.	Lysine	72-78	MAPK activated protein kinase 2	Homo sapiens	65-68
34321663-5	2021	We further show that BARD1 binds nucleosomes through multivalent interactions: coordinated binding of H2AK15ub and unmethylated H4 lysine 20 by its adjacent BUDR and ankyrin repeat domains, respectively, provides high-affinity recognition of DNA lesions in replicated chromatin and promotes the homologous recombination activities of the BRCA1-BARD1 complex.	Lysine	131-137	BRCA1 DNA repair associated	Homo sapiens	338-343
11306718-1	2001	Membrane-bound carboxypeptidase D (CPD) is a B-type carboxypeptidase that specifically cleaves C-terminal Arg or Lys from peptides and proteins.	Lysine	113-116	carboxypeptidase D	Homo sapiens	35-38
34301959-7	2021	Substitution of basally-acetylated intracellular lysine residues identified on PANX1 by mass spectrometry either prevents HDAC6-mediated activation (K140/409Q) or renders the channels constitutively active (K140R).	Lysine	49-55	pannexin 1	Homo sapiens	79-84
11305908-10	2001	Analysis of the murine cSHMT crystal structure indicates that the active site lysine that normally binds pyridoxal phosphate in the cSHMT protein is exposed to solvent in the McSHMTtr protein, preventing stable formation of a Schiff base with pyridoxal phosphate.	Lysine	78-84	serine hydroxymethyltransferase 1	Homo sapiens	23-28
34299376-4	2021	Most of the lysines within the DNA binding domain, including K36, K61, K111, K132, K148, K154, and K172, were found to be critical for DNA binding in vitro and recombination in vivo.	Lysine	12-19	keratin 36	Homo sapiens	61-64
21383990-1	2011	BACKGROUND: Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly defined.	Lysine	71-77	DOT1 like histone lysine methyltransferase	Gallus gallus	12-17
11305908-10	2001	Analysis of the murine cSHMT crystal structure indicates that the active site lysine that normally binds pyridoxal phosphate in the cSHMT protein is exposed to solvent in the McSHMTtr protein, preventing stable formation of a Schiff base with pyridoxal phosphate.	Lysine	78-84	serine hydroxymethyltransferase 1	Homo sapiens	132-137
21131355-10	2011	The kinase activity of LePRK2 was relevant for this phenotype because tubes that expressed a mutation in a lysine essential for kinase activity showed the same length and width as the eGFP control.	Lysine	107-113	receptor-like protein kinase	Solanum lycopersicum	23-29
34272277-9	2021	MK2 degradation is mediated by the E3 ubiquitin ligase MDM2, and we identify four lysine residues in MK2 that are directly ubiquitinated by MDM2.	Lysine	82-88	MAPK activated protein kinase 2	Homo sapiens	0-3
11302704-8	2001	A lysine-rich sequence within the carboxy terminus of HDAC1 is crucial for nuclear localisation of the enzyme.	Lysine	2-8	histone deacetylase 1	Mus musculus	54-59
34272277-9	2021	MK2 degradation is mediated by the E3 ubiquitin ligase MDM2, and we identify four lysine residues in MK2 that are directly ubiquitinated by MDM2.	Lysine	82-88	MDM2 proto-oncogene	Homo sapiens	55-59
34272277-9	2021	MK2 degradation is mediated by the E3 ubiquitin ligase MDM2, and we identify four lysine residues in MK2 that are directly ubiquitinated by MDM2.	Lysine	82-88	MAPK activated protein kinase 2	Homo sapiens	101-104
34272277-9	2021	MK2 degradation is mediated by the E3 ubiquitin ligase MDM2, and we identify four lysine residues in MK2 that are directly ubiquitinated by MDM2.	Lysine	82-88	MDM2 proto-oncogene	Homo sapiens	140-144
21175197-8	2011	A highly conserved aspartic acid within the MetRS SCF is proposed to make an electrostatic interaction with an active site lysine; these residues were replaced with alanines or conservative substitutions.	Lysine	123-129	KIT ligand	Homo sapiens	50-53
11319613-8	2001	These results indicate that AIP induces apoptosis in cells by two distinct mechanisms; one rapid and mediated by H2O2, the other delayed and mediated by deprivation of L-lysine, both of which utilize caspase-9/cytochrome c system.	Lysine	168-176	caspase 9	Homo sapiens	200-209
11073948-5	2001	Consistent with this observation, CBP acetylated c-Myb in vitro at Lys(438) and Lys(441) within the NRD.	Lysine	67-70	MYB proto-oncogene, transcription factor	Homo sapiens	49-54
20942812-4	2011	EXPERIMENTAL APPROACH: IL-1RA was radiolabelled by reductive amination on lysine moieties with [18F]fluoroacetaldehyde.	Lysine	74-80	interleukin 1 receptor antagonist	Rattus norvegicus	23-29
21299644-6	2011	Additionally, Lys-37 and Lys-62 were identified as being involved in ArsD function by site-directed mutagenesis and chemical modification.	Lysine	25-28	arylsulfatase D	Homo sapiens	69-73
34185510-8	2021	Furthermore, desthiobiotin-labeled lysine residues are located close to the fatty acid-binding pocket of FABP5, and the binding affinity varies with the structures of PFASs.	Lysine	35-41	fatty acid binding protein 5	Homo sapiens	105-110
34257278-3	2021	Moreover, IFN-beta also induces TRIM21 ISGylation at multiple lysine residues, thereby enhancing its E3 ligase activity for K63-linkage-specific ubiquitination and resulting in increased levels of TRIM21 and p62 K63-linked ubiquitination.	Lysine	62-68	nucleoporin 62	Homo sapiens	208-211
34373735-3	2021	The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L.	Lysine	72-78	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	22-25
34373735-3	2021	The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L.	Lysine	72-78	H3 clustered histone 7	Mus musculus	61-71
11073948-5	2001	Consistent with this observation, CBP acetylated c-Myb in vitro at Lys(438) and Lys(441) within the NRD.	Lysine	80-83	MYB proto-oncogene, transcription factor	Homo sapiens	49-54
21068446-4	2011	beta-TrCP ubiquitinates LPCAT1 at an acceptor site (Lys(221)), as substitution of Lys(221) with Arg abrogated LPCAT1 polyubiquitination.	Lysine	52-55	lysophosphatidylcholine acyltransferase 1	Homo sapiens	24-30
11073948-7	2001	Replacement of lysine by arginine at all of these sites dramatically decreased the trans-activating capacity of c-Myb.	Lysine	15-21	MYB proto-oncogene, transcription factor	Homo sapiens	112-117
11368010-2	2001	In this study, we used a site-directed mutagenesis approach to determine a role for two lysine residues (Lys271 and Lys279) of cytochrome P4501A1 in the interaction of P4501A1 with reductase.	Lysine	88-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-145
21297974-6	2011	We found that the pro-angiogenic effects are partly mediated through reduced repression by miR-101 of the histone-methyltransferase EZH2, a member of the Polycomb group family, thereby increasing methylation of histone H3 at lysine 27 and transcriptome alterations.	Lysine	225-231	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	132-136
34238215-17	2021	High glucose attenuated KMT5A levels and histone H4 lysine 20 methylation (H4K20me1), one of the downstream targets of KMT5A.	Lysine	52-58	lysine methyltransferase 5A	Rattus norvegicus	119-124
11118214-4	2000	P/CAF-mediated acetylation, which mapped to a lysine-rich motif in the loop region, increased TAL1 binding to DNA while selectively inhibiting its interaction with the transcriptional co-repressor mSin3A.	Lysine	46-52	TAL bHLH transcription factor 1, erythroid differentiation factor	Homo sapiens	94-98
34135062-7	2021	Mechanistically, USP19 removed the K63-linked ubiquitin chain from RORgammat lysine 313, which is essential for recruiting the coactivator SRC3.	Lysine	77-83	ubiquitin specific peptidase 19	Homo sapiens	17-22
21249157-0	2011	Identification of lysine 37 of histone H2B as a novel site of methylation.	Lysine	18-24	histone H2B	Saccharomyces cerevisiae S288C	31-42
21249157-3	2011	Here, using the top-down mass spectrometry approach for identifying PTMs on full-length histones, we report that lysine 37 of histone H2B is dimethylated in the budding yeast Saccharomyces cerevisiae.	Lysine	113-119	histone H2B	Saccharomyces cerevisiae S288C	126-137
34140642-5	2021	We showed that mechanistically complement factor H-related protein (CFHR), as a major E3 ligase, promotes Plk1 degradation by ubiquitinating it at lysine 209.	Lysine	147-153	polo like kinase 1	Homo sapiens	106-110
11070020-7	2000	Using this approach, we found that the budding efficiency of RSV Gag can be improved by adding pairs of lysines and that the basic residues in the M domain can be repositioned without affecting particle release.	Lysine	104-111	Pr76 polyprotein precursor	Rous sarcoma virus	65-68
34204393-5	2021	METHODS: Using chromatin immunoprecipitation sequencing, we investigated the distribution of the trimethylation of lysine 4 of histone H3 in the liver of mice fed for one year with five different diets, including: chow containing yellow corn powder as an extra source of plant bioactives or specifically enriched with cyanidin-3-O-Glucoside, high-fat-enriched obesogenic diets, and caloric-restricted pro-longevity diets.	Lysine	115-121	H3 clustered histone 7	Mus musculus	127-137
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Lysine	152-155	zinc finger, DHHC domain containing 21	Mus musculus	40-43
34199982-4	2021	Furthermore, the influence of the mitochondrial status on cytosolic NAD+ availability affecting the activity of cytosolic SIRT5 iso1 and iso4-in turn regulating cytosolic protein lysine succinylations-is presented.	Lysine	179-185	eukaryotic translation initiation factor 1	Homo sapiens	128-132
34077484-7	2021	Interestingly, NDRG1 enhanced the stability of ORF44 and inhibited its ubiquitin-proteasome-mediated degradation by reducing the polyubiquitination of the lysine residues at positions 79 and 368 in ORF44.	Lysine	155-161	N-myc downstream regulated 1	Homo sapiens	15-20
21245904-3	2011	Here, we have dissected the neuronal function of the Drosophila euchromatin histone methyltransferase (EHMT), a member of a conserved protein family that methylates histone 3 at lysine 9 (H3K9).	Lysine	178-184	G9a	Drosophila melanogaster	64-101
21245904-3	2011	Here, we have dissected the neuronal function of the Drosophila euchromatin histone methyltransferase (EHMT), a member of a conserved protein family that methylates histone 3 at lysine 9 (H3K9).	Lysine	178-184	G9a	Drosophila melanogaster	103-107
21206046-1	2011	In the anabolic synthesis of diaminopimelate and lysine in plants and in some bacteria, the enzyme L,L-diaminopimelate aminotransferase (DapL; EC 2.6.1.83) catalyzes the conversion of tetrahydrodipicolinic acid (THDPA) to L,L-diaminopimelate, bypassing the DapD, DapC and DapE enzymatic steps in the bacterial acyl pathways.	Lysine	49-55	uncharacterized protein	Chlamydomonas reinhardtii	99-135
34077484-7	2021	Interestingly, NDRG1 enhanced the stability of ORF44 and inhibited its ubiquitin-proteasome-mediated degradation by reducing the polyubiquitination of the lysine residues at positions 79 and 368 in ORF44.	Lysine	155-161	ORF44	Human gammaherpesvirus 8	47-52
34077484-7	2021	Interestingly, NDRG1 enhanced the stability of ORF44 and inhibited its ubiquitin-proteasome-mediated degradation by reducing the polyubiquitination of the lysine residues at positions 79 and 368 in ORF44.	Lysine	155-161	ORF44	Human gammaherpesvirus 8	198-203
21206046-1	2011	In the anabolic synthesis of diaminopimelate and lysine in plants and in some bacteria, the enzyme L,L-diaminopimelate aminotransferase (DapL; EC 2.6.1.83) catalyzes the conversion of tetrahydrodipicolinic acid (THDPA) to L,L-diaminopimelate, bypassing the DapD, DapC and DapE enzymatic steps in the bacterial acyl pathways.	Lysine	49-55	uncharacterized protein	Chlamydomonas reinhardtii	137-141
10906148-2	2000	Among Ub-conjugating enzymes, E2-25K is unique in its ability to synthesize in vitro unanchored Lys(48)-linked poly-Ub chains from mono- or poly-Ub, E1, and ATP; thus, E2-25K has distinct binding sites for donor and acceptor (poly)Ub.	Lysine	96-99	ubiquitin conjugating enzyme E2 K	Homo sapiens	30-36
21205864-3	2011	In Drosophila, two enzymes, dLsd1 (Drosophila ortholog of lysine-specific demethylase 1) and Lid (little imaginal discs), demethylate histone H3 at Lys 4 (H3K4), a residue whose methylation is associated with actively transcribed genes.	Lysine	148-151	Lipid storage droplet-1	Drosophila melanogaster	28-33
34458839-0	2021	Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2-nucleosome association.	Lysine	0-6	high mobility group nucleosomal binding domain 2	Homo sapiens	56-62
34458839-0	2021	Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2-nucleosome association.	Lysine	0-6	high mobility group nucleosomal binding domain 2	Homo sapiens	64-69
34458839-0	2021	Lysine succinylation on non-histone chromosomal protein HMG-17 (HMGN2) regulates nucleosomal DNA accessibility by disrupting the HMGN2-nucleosome association.	Lysine	0-6	high mobility group nucleosomal binding domain 2	Homo sapiens	129-134
10906148-2	2000	Among Ub-conjugating enzymes, E2-25K is unique in its ability to synthesize in vitro unanchored Lys(48)-linked poly-Ub chains from mono- or poly-Ub, E1, and ATP; thus, E2-25K has distinct binding sites for donor and acceptor (poly)Ub.	Lysine	96-99	ubiquitin conjugating enzyme E2 K	Homo sapiens	168-174
21318022-2	2011	Lysyl oxidase (LO), a Cu-dependent enzyme, oxidizes peptidyl lysine residues in collagen, elastin and histone H1, essential for stabilization of the extracellular matrix and cell nucleus.	Lysine	61-67	lysyl oxidase	Homo sapiens	0-13
21318022-2	2011	Lysyl oxidase (LO), a Cu-dependent enzyme, oxidizes peptidyl lysine residues in collagen, elastin and histone H1, essential for stabilization of the extracellular matrix and cell nucleus.	Lysine	61-67	lysyl oxidase	Homo sapiens	15-17
10906148-3	2000	During studies of chain assembly by E2-25K, we observed that Lys(48)-linked tri-Ub was efficiently converted to a new species that upon SDS-polyacrylamide gel electrophoresis migrated between linear di-Ub and tri-Ub.	Lysine	61-64	ubiquitin conjugating enzyme E2 K	Homo sapiens	36-42
21318022-2	2011	Lysyl oxidase (LO), a Cu-dependent enzyme, oxidizes peptidyl lysine residues in collagen, elastin and histone H1, essential for stabilization of the extracellular matrix and cell nucleus.	Lysine	61-67	elastin	Homo sapiens	90-97
21318022-2	2011	Lysyl oxidase (LO), a Cu-dependent enzyme, oxidizes peptidyl lysine residues in collagen, elastin and histone H1, essential for stabilization of the extracellular matrix and cell nucleus.	Lysine	61-67	H1.0 linker histone	Homo sapiens	102-112
35470136-3	2022	In the neonate, pyridoxine was administered followed by cessation of seizures and a diagnosis of pyridoxine-dependent epilepsy (PDE-ALDH7A1, a neurometabolic disorder of lysine metabolism) was genetically confirmed.	Lysine	170-176	aldehyde dehydrogenase 7 family member A1	Homo sapiens	128-131
35470136-3	2022	In the neonate, pyridoxine was administered followed by cessation of seizures and a diagnosis of pyridoxine-dependent epilepsy (PDE-ALDH7A1, a neurometabolic disorder of lysine metabolism) was genetically confirmed.	Lysine	170-176	aldehyde dehydrogenase 7 family member A1	Homo sapiens	132-139
11029294-5	2000	An NH(2)-terminal residue (Lys-53) was found to be responsible for the low pH sensitivity in Kir4.1.	Lysine	27-30	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	93-99
35354308-8	2022	Subsequent RNA-seq, proteomics, and immunoprecipitation experiments showed that wild-type ALDH2 directly interacted with Rac2 and attenuated its degradation due to decreasing the K48-linked polyubiquitination of lysine 123 in Rac2, whereas the rs671 mutant markedly destabilized Rac2.	Lysine	212-218	Rac family small GTPase 2	Mus musculus	121-125
20424637-5	2011	The results of chemical amino-acid modifications and molecular mutagenesis together suggest that two specific lysine residues in the structural element linking the transmembrane ion-permeation domain to the carboxyl cytosolic domain of the Slo1 channel are critical in determining the sensitivity of the channel to BOXes.	Lysine	110-116	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	240-244
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	Lysine	26-32	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	59-65
35614130-5	2022	Mechanistically, HDAC6 directly deacetylated CBP-catalyzed acetylation of signal transducer and activator of transcription 4 (STAT4)-lysine (K) 667 via its enzymatic activity.	Lysine	133-139	signal transducer and activator of transcription 4	Mus musculus	126-131
11046145-4	2000	Interestingly, CBP and PCAF acetylate CIITA at lysine residues within a nuclear localization signal.	Lysine	47-53	class II major histocompatibility complex transactivator	Homo sapiens	38-43
11046145-6	2000	The shuttling behavior and activity of the protein are regulated by acetylation: overexpression of PCAF or inhibition of cellular deacetylases by trichostatin A increases the nuclear accumulation of CIITA in a manner determined by the presence of the acetylation target lysines.	Lysine	270-277	class II major histocompatibility complex transactivator	Homo sapiens	199-204
35597640-8	2022	Holo BCCP contains one biotinylation site, and FKBP3 was modeled with up to 23 biotinylated lysines.	Lysine	92-99	FKBP prolyl isomerase 3	Homo sapiens	47-52
11395138-0	2000	Lysine 322 in the human IgG3 C(H)2 domain is crucial for antibody dependent complement activation.	Lysine	0-6	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	24-28
35636243-6	2022	Further validation of three proteins, HMGCS1 (cholesterol synthesis), P4HA1 (glycolysis) and KDM5A (demethylation of histone 3 at lysine 4), confirmed their significant differential abundance, respectively.	Lysine	130-136	lysine demethylase 5A	Homo sapiens	93-98
20980512-4	2011	Mutation of all potential ubiquitination sites in the cytoplasmic domain of BST-2, including lysines, cysteines, serines, and threonines, abrogates Vpu-mediated ubiquitination.	Lysine	93-100	bone marrow stromal cell antigen 2	Homo sapiens	76-81
20980512-4	2011	Mutation of all potential ubiquitination sites in the cytoplasmic domain of BST-2, including lysines, cysteines, serines, and threonines, abrogates Vpu-mediated ubiquitination.	Lysine	93-100	Vpu	Human immunodeficiency virus 1	148-151
21047957-4	2011	Furthermore, two lysine residues in the C terminus of NS1 were identified as SUMO1 acceptor sites.	Lysine	17-23	influenza virus NS1A binding protein	Homo sapiens	54-57
11395138-2	2000	The C1q binding site on mouse IgG2b has been shown to contain the amino acids Glu 318, Lys 320 and Lys 322 in the C(H)2 domain (Duncan, A.R., Winter, G.,1988.	Lysine	87-90	complement C1q A chain	Homo sapiens	4-7
11395138-2	2000	The C1q binding site on mouse IgG2b has been shown to contain the amino acids Glu 318, Lys 320 and Lys 322 in the C(H)2 domain (Duncan, A.R., Winter, G.,1988.	Lysine	99-102	complement C1q A chain	Homo sapiens	4-7
35567477-9	2022	We show that the Esa1 lysine acetyltransferase activity is critical for suppression of the caffeine sensitive growth of H3K36R mutant cells while the previously characterized binding interactions of Tos4 and Pho92 are not required for suppression.	Lysine	22-28	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	17-21
21120624-5	2011	Furthermore, we identified the five lysine residues of the Pellino-1 protein where SUMO-1 covalently attaches.	Lysine	36-42	pellino E3 ubiquitin protein ligase 1	Homo sapiens	59-68
11056215-2	2000	The nuclear import of rpL22 depends on a classical nuclear localization signal of four lysines at positions 13-16.	Lysine	87-94	ribosomal protein L22	Homo sapiens	22-27
21041098-6	2011	Ubiquitination sites were found at three lysine residues (130, 143 and 145) of oleosin-H and two lysine residues (165 and 235) of caleosin.	Lysine	97-103	peroxygenase	Sesamum indicum	130-138
35551465-5	2022	We find that the elevated expression of VEGFR2 is epigenetically regulated via intrinsic acetylation of histone 3 at lysine 27 by histone acetyltransferase P300.	Lysine	117-123	kinase insert domain receptor	Homo sapiens	40-46
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	14-17	solute carrier family 7 member 1	Homo sapiens	72-78
11035102-0	2000	The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor.	Lysine	26-29	formyl peptide receptor 1	Mus musculus	90-113
35634396-7	2022	Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal Slc7a1, Slc7a2, and Slc15a1 and ileal Slc7a2.	Lysine	18-21	solute carrier family 7 member 1	Homo sapiens	72-78
35247902-4	2022	Mechanistically, ZNF384 FO occupy a subset of predominantly intragenic/enhancer regions with increased histone 3 lysine acetylation and deregulate expression of hematopoietic stem cell transcription factors.	Lysine	113-119	zinc finger protein 384	Homo sapiens	17-23
21164480-4	2010	The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional unit for combinatorial recognition of unmodified H3K4 (that is, histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3 acetylated at lysine 23, H3K23ac) within the same histone tail.	Lysine	184-190	tripartite motif containing 24	Homo sapiens	59-65
21164480-4	2010	The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional unit for combinatorial recognition of unmodified H3K4 (that is, histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3 acetylated at lysine 23, H3K23ac) within the same histone tail.	Lysine	250-256	tripartite motif containing 24	Homo sapiens	59-65
11048939-6	2000	In Trial 2, postruminal administration of 16 g/d of L-lysine from L-lysine monohydrochloride increased ADG, gain/feed, and N utilization efficiency compared with a control group receiving a N-free supplement.	Lysine	52-60	ADG	Bos taurus	103-106
21179466-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: Using a transgenic RNA-interference strategy to selectively silence CBP, Psn, and Notch in adult Drosophila, we provide evidence for the first time that Psn is required for normal CBP levels and for maintaining specific global acetylations at lysine 8 of histone 4 (H4K8ac) in the central nervous system (CNS).	Lysine	275-281	nejire	Drosophila melanogaster	100-103
35351830-5	2022	We here dissect a higher primates-restricted interaction between RbFOX1 and the transcriptional corepressor Lysine Specific Demethylase 1 (LSD1/KDM1A).	Lysine	108-114	lysine demethylase 1A	Homo sapiens	139-143
35351830-5	2022	We here dissect a higher primates-restricted interaction between RbFOX1 and the transcriptional corepressor Lysine Specific Demethylase 1 (LSD1/KDM1A).	Lysine	108-114	lysine demethylase 1A	Homo sapiens	144-149
11048939-6	2000	In Trial 2, postruminal administration of 16 g/d of L-lysine from L-lysine monohydrochloride increased ADG, gain/feed, and N utilization efficiency compared with a control group receiving a N-free supplement.	Lysine	66-92	ADG	Bos taurus	103-106
35621100-1	2022	Human translational methyltransferase (methylase) HEMK2, whose orthologues are found in many prokaryotes and eukaryotes, methylates such diverse substrates as glutamine and lysine residues in proteins, deoxyadenosine in DNA, and arsenicals.	Lysine	173-179	N-6 adenine-specific DNA methyltransferase 1	Homo sapiens	50-55
20947501-1	2010	Histone deacetylase 9 (HDAC9), like most Class II HDACs, catalyzes the removal of acetyl moieties from the epsilon-amino groups of conserved lysine residues in the N-terminal tail of histones.	Lysine	141-147	histone deacetylase 9	Homo sapiens	0-21
20947501-1	2010	Histone deacetylase 9 (HDAC9), like most Class II HDACs, catalyzes the removal of acetyl moieties from the epsilon-amino groups of conserved lysine residues in the N-terminal tail of histones.	Lysine	141-147	histone deacetylase 9	Homo sapiens	23-28
11013004-3	2000	We show here, by site-directed mutagensis, that the lysine at position 57 in the complementarity-determining region 2 (CDR-2) of the V3-30 gene product is crucial for epitope recognition by all three anti-VH3 MoAbs.	Lysine	52-58	immunoglobulin heavy variable 3-75 (pseudogene)	Homo sapiens	205-208
10887182-6	2000	This protein, which we have termed IHABP4, was also found to be an intracellular and a specific hyaluronan-binding protein, containing several hyaluronan-binding motifs: (R/K)[X(7)](R/K) (where R/K denotes arginine or lysine and X denotes non-acidic amino acids).	Lysine	218-224	hyaluronic acid binding protein 4	Mus musculus	35-41
21145476-3	2010	(2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.	Lysine	158-164	lysine demethylase 4A	Homo sapiens	40-45
35210358-5	2022	We show that the PB1 domain and adjacent linker region of p62 (aa 1-122) are necessary and sufficient for specific vault RNA1-1 binding, and identify lysine 7 and arginine 21 as key hinges for p62 riboregulation.	Lysine	150-156	nucleoporin 62	Homo sapiens	58-61
35210358-5	2022	We show that the PB1 domain and adjacent linker region of p62 (aa 1-122) are necessary and sufficient for specific vault RNA1-1 binding, and identify lysine 7 and arginine 21 as key hinges for p62 riboregulation.	Lysine	150-156	nucleoporin 62	Homo sapiens	193-196
10985795-1	2000	Glutaryl-CoA dehydrogenase catalyzes the oxidation of glutaryl-CoA to crotonyl-CoA and CO(2) in the mitochondrial degradation of lysine, hydroxylysine, and tryptophan.	Lysine	129-135	glutaryl-CoA dehydrogenase	Homo sapiens	0-26
35592435-6	2022	A significant decrease in dimethylated H3K9 (Dimethylation of lysine 9 on histone 3) levels in the MGMT promoter in DNA hypo- and hypermethylated HCT-116G13D and SW-620G12V cells was observed after treatment.	Lysine	62-68	O-6-methylguanine-DNA methyltransferase	Homo sapiens	99-103
35278818-9	2022	In general, the successful application of the new bifunctional chelator in labeling dipeptide Glu-urea-Lys with Al18F could facilitate its possibility in conjugating with other peptides for PET imaging with enhanced in vivo stability, thus providing better in vivo performances.	Lysine	103-106	thyroid stimulating hormone receptor	Mus musculus	190-193
21112291-4	2010	On the basis of data from extensive (&gt;0.55 mus) molecular dynamics simulations of multiple Kras anchors in bilayers of POPC/POPG lipids (4:1 ratio), we show that, as expected, Kras is tethered to the bilayer surface by specific lysine-POPG salt bridges and by nonspecific farnesyl-phospholipid van der Waals interactions.	Lysine	231-237	KRAS proto-oncogene, GTPase	Homo sapiens	179-183
21112291-5	2010	Unexpectedly, however, only the C-terminal five of the eight Kras Lys side chains were found to directly interact with the bilayer, with the N-terminal ones staying in water.	Lysine	66-69	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
10974350-3	2000	The interaction of plasminogen was significantly (&gt;90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.	Lysine	72-78	serpin family C member 1	Homo sapiens	130-146
20050948-13	2010	Addition of 1 or 2 g/kg MOS significantly increased the ileal digestibility of lysine, methionine, cystine and threonine with the same magnitude or even more than the AGP.	Lysine	79-85	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	24-27
35419695-2	2022	Further studies have demonstrated that SETD3 may be able to methylase some other residues, including lysine and methionine, that substitute His73 in the beta-actin peptide.	Lysine	101-107	POTE ankyrin domain family member F	Homo sapiens	153-163
10974350-6	2000	Using carboxypeptidase B digestion, the plasminogen-binding site of antithrombin III was localized to the carboxy-terminus lysine of the anticoagulant protein.	Lysine	123-129	serpin family C member 1	Homo sapiens	68-84
10974350-7	2000	Tissue plasminogen activator also interacted with antithrombin III in a time- and concentration-dependent manner and its binding was also significantly (&gt;90%) inhibited by lysine.	Lysine	175-181	serpin family C member 1	Homo sapiens	50-66
10947954-10	2000	The nucleotide sequence of HHR GST subunit 3 cDNA proved identical to that reported for pGTA/C44, possessing asparagine and cysteine as the 198th and 199th amino acid residues, respectively, corresponding to lysine and serine in subunit 3 of the SD rat.	Lysine	208-214	alpha-1-B glycoprotein	Rattus norvegicus	93-96
35143753-7	2022	Finally, LSD1 knockdown inhibited VSMC proliferation by increasing p21 expression, which is associated with LSD1 mediated di-methylated histone H3 on lysine 4 (H3K4me2) modification.	Lysine	150-156	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	67-70
21062871-3	2010	Methylation of lysine and glutamic acid residues was recently described on the N-terminal tail of AtPIP2;1, a plasma membrane aquaporin of plants.	Lysine	15-21	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	98-106
20974918-7	2010	Our structural data provide an explanation for the preferential recognition of the Ala-Arg-Lys-Ser motif-containing trimethylated H3K27, H3K9, and H1K26 marks by EED over lower methylation states and other histone methyllysine marks.	Lysine	91-94	embryonic ectoderm development	Homo sapiens	162-165
35351142-14	2022	Furthermore, histone H4-Lys-20 monomethylation (H4K20me1), which is downstream of SETD8, was accompanied by ELK1 localization at the same promoter region of bach1.	Lysine	24-27	ETS transcription factor ELK1	Homo sapiens	108-112
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Lysine	165-168	EcoRII restriction enzyme	Escherichia coli	33-39
35338235-8	2022	ChIP-PCR affirmed that KDM3A bound to the ETS1 promoter and removed dimethylation of histone H3 lysine 9 (H3K9me2), thus promoting ETS1 transcription.	Lysine	96-102	lysine demethylase 3A	Rattus norvegicus	23-28
20846141-1	2010	By means of an in silico analysis, we demonstrated that a previously described chimeric gene (Spe-Sdh) encoding spermidine synthase, a key enzyme involved in the synthesis of polyamines, and saccharopine dehydrogenase, an enzyme involved in lysine synthesis in fungi, were present exclusively in members of all Basidiomycota subphyla, but not in any other group of living organisms.	Lysine	241-247	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	98-101
35338235-8	2022	ChIP-PCR affirmed that KDM3A bound to the ETS1 promoter and removed dimethylation of histone H3 lysine 9 (H3K9me2), thus promoting ETS1 transcription.	Lysine	96-102	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	131-135
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Lysine	165-168	EcoRII restriction enzyme	Escherichia coli	130-136
35331172-8	2022	The other 5 metabolites were down-regulated in the anti-TPO antibodies positivity group, including L-Leucine, L-Lysine, L-Glutamic acid, L-Tyrosine, and L-Phenylalanine.	Lysine	110-118	thyroid peroxidase	Homo sapiens	56-59
20833801-0	2010	L-lysine catabolism is controlled by L-arginine and ArgR in Pseudomonas aeruginosa PAO1.	Lysine	0-8	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	52-56
20833801-2	2010	In this study, the ldcA gene (lysine decarboxylase A; PA1818), previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism in this organism.	Lysine	167-175	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	104-108
20870941-5	2010	Lysines within the cytoplasmic domain of Mult1 were essential for this repression by MARCH4 or MARCH9.	Lysine	0-7	membrane associated ring-CH-type finger 4	Homo sapiens	85-91
20870941-5	2010	Lysines within the cytoplasmic domain of Mult1 were essential for this repression by MARCH4 or MARCH9.	Lysine	0-7	membrane associated ring-CH-type finger 9	Homo sapiens	95-101
20805357-5	2010	Moreover, HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo.	Lysine	81-87	host cell factor C1	Homo sapiens	10-15
21048924-10	2010	Statistical tests also showed gene-gene interaction of ADH1B Arg+ with ALDH2 Lys+ can bring more risk to ESCC (OR  = 13.46, 95% CI: 2.32-78.07).	Lysine	77-80	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	55-60
20702416-2	2010	The Toll signaling pathway responds mainly to the lysine-type peptidoglycan of Gram-positive bacteria and fungal beta-1,3-glucan, whereas the Imd pathway responds to the meso-diaminopimelic acid (DAP)-type peptidoglycan of Gram-negative bacteria and certain Gram-positive bacilli.	Lysine	50-56	Toll	Drosophila melanogaster	4-8
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	0-6
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	COP9 signalosome subunit 5	Homo sapiens	18-22
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	COP9 signalosome subunit 5	Homo sapiens	27-32
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	BRCA1 DNA repair associated	Homo sapiens	189-194
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	ubiquitin interaction motif containing 1	Homo sapiens	195-200
20656689-1	2010	BRCC36 is a JAMM (JAB1/MPN/Mov34 metalloenzyme) domain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protein complexes: the DNA damage-responsive BRCA1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).	Lysine	56-62	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	230-236
20656690-1	2010	BRCC36 is a member of the JAMM/MPN(+) family of zinc metalloproteases that specifically cleaves Lys 63-linked polyubiquitin chains in vitro.	Lysine	96-99	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	0-6
20656690-4	2010	Here we provide evidence indicating that BRCC36 regulates the abundance of Lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone H2A.	Lysine	75-78	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	41-47
20696840-7	2010	We show that this results from IkappaBalpha sumoylation by Sumo-2/3 on critical lysine residues, normally required for K-48-linked polyubiquitination.	Lysine	80-86	small ubiquitin like modifier 2	Homo sapiens	59-67
20852628-4	2010	Whereas SCFFbw7 with the Cdc34 ubiquitin-conjugating enzyme specifically requires lysine 48 (K48) of ubiquitin, SCFbeta-TrCP uses the UbcH5 ubiquitin-conjugating enzyme to form heterotypic polyubiquitin chains on Myc.	Lysine	82-88	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	25-30
20850016-6	2010	The ORC complex, including LRWD1, binds to the three most prominent transcriptional repressive lysine methylation sites.	Lysine	95-101	leucine rich repeats and WD repeat domain containing 1	Homo sapiens	27-32
20847274-5	2010	gamma-actin was translated more slowly than beta-actin, and this slower processing resulted in the exposure of a normally hidden lysine residue for ubiquitination, leading to the preferential degradation of gamma-actin upon arginylation.	Lysine	129-135	POTE ankyrin domain family member F	Homo sapiens	44-54
20599488-2	2010	The polycationic peptide was obtained by assembling Fmoc and Boc orthogonally protected l-lysine monomers by solid phase synthesis.	Lysine	88-96	BOC cell adhesion associated, oncogene regulated	Homo sapiens	61-64
20833367-6	2010	Importantly, in vivo chromatin immunoprecipitation reveals direct stage-specific interactions of JmjD2A with regulatory regions of neural crest genes, and associated temporal modifications in methylation states of lysine residues directly affected by JmjD2A activity.	Lysine	214-220	lysine demethylase 4A	Homo sapiens	251-257
20832724-4	2010	Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to their having decreased histone levels.	Lysine	81-87	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	44-48
20844582-3	2010	Our previous study showed that the SUMO E3 ligase PIASy interacts with VHL and induces VHL SUMOylation on lysine residue 171 (Cai et al, PLoS ONE, 2010, 5(3):e9720).	Lysine	106-112	protein inhibitor of activated STAT 4	Homo sapiens	50-55
20844582-4	2010	Here we further report that VHL also undergoes ubiquitylation on both lysine residues 171 and 196, which is blocked by PIASy.	Lysine	70-76	protein inhibitor of activated STAT 4	Homo sapiens	119-124
20724660-5	2010	Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23).	Lysine	80-83	inhibitor of kappaB kinase gamma	Mus musculus	117-121
20724660-5	2010	Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23).	Lysine	80-83	tripartite motif-containing 23	Mus musculus	155-181
20724660-5	2010	Here, we show that virus-induced IRF3 and NF-kappaB activation depends on the K(lys)-27-linked polyubiquitination to NEMO by the novel ubiquitin E3 ligase triparite motif protein 23 (TRIM23).	Lysine	80-83	tripartite motif-containing 23	Mus musculus	183-189
20584900-4	2010	Here we show that KLF4 is both SUMOylated at a single lysine residue and physically interacts with SUMO-1 in a region that matches an acidic and hydrophobic residue-rich SUMO-interacting motif (SIM) consensus.	Lysine	54-60	Kruppel like factor 4	Homo sapiens	18-22
21171714-7	2010	With poly-L-lysine as the underlying layer, biologically significant differences (greater than twofold) in the expression of VWF, VEGFR, VEGFA, endoglin, and ICAM1 were observed among the three glycosaminoglycans.	Lysine	5-18	kinase insert domain receptor	Homo sapiens	130-135
21171714-7	2010	With poly-L-lysine as the underlying layer, biologically significant differences (greater than twofold) in the expression of VWF, VEGFR, VEGFA, endoglin, and ICAM1 were observed among the three glycosaminoglycans.	Lysine	5-18	intercellular adhesion molecule 1	Homo sapiens	158-163
20549206-2	2010	In this study, we sought to determine critical roles of host IFN-alpha and IFN-gamma pathways in the enhanced therapeutic efficacy mediated by peptide vaccines and polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in the murine central nervous system (CNS) GL261 glioma.	Lysine	222-228	interferon alpha	Mus musculus	61-70
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 3	Homo sapiens	6-10
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 3	Homo sapiens	64-68
20723759-4	2010	ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.	Lysine	160-166	autophagy related 3	Homo sapiens	64-68
20704751-8	2010	Our recent studies of this model system demonstrated that residues surrounding Sic1 lysines or lysine 48 in ubiquitin are critical for ubiquitination.	Lysine	84-91	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	79-83
20704751-8	2010	Our recent studies of this model system demonstrated that residues surrounding Sic1 lysines or lysine 48 in ubiquitin are critical for ubiquitination.	Lysine	84-90	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	79-83
20704751-10	2010	Our studies indicate that amino acid determinants in the Cdc34 catalytic region and their compatibility to those surrounding acceptor lysine residues play important roles in lysine selection.	Lysine	134-140	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	57-62
20704751-10	2010	Our studies indicate that amino acid determinants in the Cdc34 catalytic region and their compatibility to those surrounding acceptor lysine residues play important roles in lysine selection.	Lysine	174-180	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	57-62
20583823-6	2010	Our results show that the PDCA-dimethyl ester inhibits JMJD2A catalyzed demethylation of lysine-9 on histone H3 in human HEK 293T cells.	Lysine	89-95	lysine demethylase 4A	Homo sapiens	55-61
20616235-4	2010	The ability to tether two distinct complexes enables RNA-mediated assembly of PRC2 and LSD1 and coordinates targeting of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation.	Lysine	171-177	lysine demethylase 1A	Homo sapiens	87-91
20616235-4	2010	The ability to tether two distinct complexes enables RNA-mediated assembly of PRC2 and LSD1 and coordinates targeting of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation.	Lysine	171-177	lysine demethylase 1A	Homo sapiens	130-134
20616235-4	2010	The ability to tether two distinct complexes enables RNA-mediated assembly of PRC2 and LSD1 and coordinates targeting of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation.	Lysine	197-203	lysine demethylase 1A	Homo sapiens	87-91
20616235-4	2010	The ability to tether two distinct complexes enables RNA-mediated assembly of PRC2 and LSD1 and coordinates targeting of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation.	Lysine	197-203	lysine demethylase 1A	Homo sapiens	130-134
20630764-0	2010	N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.	Lysine	20-26	sirtuin 1	Homo sapiens	53-58
20630764-2	2010	Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel N(epsilon)-modified lysine containing inhibitors against SIRT1 and SIRT2.	Lysine	124-130	sirtuin 1	Homo sapiens	161-166
20699646-6	2010	Recently, we have shown that the lysine acetyltransferase Gcn5 and H3 N-terminal tail lysine acetylation also regulates the interaction between H3-H4 and CAF-1 to promote the deposition of newly-synthesized histones.	Lysine	33-39	lysine acetyltransferase 2A	Homo sapiens	58-62
20452239-6	2010	Using this approach, the experimentally determined relative solvent accessibilities of the lysine residues were found to show good agreement with the known solution structure of CRABP II.	Lysine	91-97	cellular retinoic acid binding protein 2	Homo sapiens	178-186
20639885-1	2010	The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former"s N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2-p53 association.	Lysine	167-173	MDM2 proto-oncogene	Homo sapiens	63-67
20639885-1	2010	The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former"s N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2-p53 association.	Lysine	167-173	MDM2 proto-oncogene	Homo sapiens	200-204
20639885-1	2010	The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former"s N-terminal region and core domain, yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modifications that inhibit Mdm2-p53 association.	Lysine	167-173	MDM2 proto-oncogene	Homo sapiens	200-204
20516063-3	2010	Here we found that BZLF1 is conjugated at lysine 12 not only by SUMO-1 but also by SUMO-2 and 3.	Lysine	42-48	small ubiquitin like modifier 2	Homo sapiens	83-95
20670405-8	2010	mH2A1 consistently colocalizes with a heterochromatin marker (H3K27me2; histone H3 trimethylated at lysine 27) and mH2A2 with a euchromatin marker (H3K4me3; histone H3 trimethylated at lysine 4).	Lysine	100-106	H2A clustered histone 4	Mus musculus	0-5
20670405-8	2010	mH2A1 consistently colocalizes with a heterochromatin marker (H3K27me2; histone H3 trimethylated at lysine 27) and mH2A2 with a euchromatin marker (H3K4me3; histone H3 trimethylated at lysine 4).	Lysine	185-191	H2A clustered histone 4	Mus musculus	0-5
20615951-2	2010	A natural mutant, opaque 2 (o2) causes reduction of zeins, an increase of nonzein proteins, and as a consequence, a doubling of lysine levels.	Lysine	128-134	regulatory protein opaque-2	Zea mays	28-30
20613843-6	2010	Whereas the interaction with H3 is promoted by acetylation at lysine 14, it is inhibited by methylation at lysine 4, and these opposing influences are important during transcriptional activation of the mouse DPF3b target genes Pitx2 and Jmjd1c.	Lysine	107-113	jumonji domain containing 1C	Mus musculus	237-243
20424159-3	2010	Sumoylation involves activation and transfer of small ubiquitin-like modifier (SUMO) from the thioester of E1 to the thioester of Ubc9 (E2) and final transfer to lysines on target proteins, which is enhanced by E3s.	Lysine	162-169	ubiquitin-conjugating enzyme E2I	Mus musculus	130-134
35258919-3	2022	Here, we developed a novel Lys-AuNPs@MoS2 nanocomposite self-assembled microfluidic immunoassay biochip with digital signal output and applied it to the simultaneous detection of multiple serum biomarkers including inflammatory factors and cardiovascular biomarkers, PCT, CRP, IL6, cTnI, cTnT, and NT-BNP, with high throughput and sensitivity.	Lysine	27-30	troponin I3, cardiac type	Homo sapiens	282-286
35298257-3	2022	Our results indicate that genomic instability in the absence of ATXR5/ATXR6-catalyzed histone H3 lysine 27 monomethylation in plants depends on H3.1, TSK, and DNA polymerase theta (Pol theta).	Lysine	97-103	tsukushi, small leucine rich proteoglycan	Homo sapiens	150-153
35264561-0	2022	Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.	Lysine	20-26	sirtuin 1	Homo sapiens	0-9
35264561-6	2022	We generated antibodies selective for TDP-43 acetylated at these lysines, and found that sirtuin-1 can potently deacetylate K136-acetylated TDP-43 and reduce its aggregation propensity.	Lysine	65-72	sirtuin 1	Homo sapiens	89-98
35058288-9	2022	Peli1 inhibited the PKCtheta pathway by lysine 48-mediated ubiquitination degradation in CD8+ TILs.	Lysine	40-46	pellino E3 ubiquitin protein ligase 1	Homo sapiens	0-5
35058288-9	2022	Peli1 inhibited the PKCtheta pathway by lysine 48-mediated ubiquitination degradation in CD8+ TILs.	Lysine	40-46	CD8a molecule	Homo sapiens	89-92
35143843-0	2022	A lysine-rich cluster in the N-BAR domain of ARF GTPase-activating protein ASAP1 is necessary for binding and bundling actin filaments.	Lysine	2-8	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	75-80
35143843-8	2022	Taken together, our results support the hypothesis that the lysine-rich cluster in the N-BAR domain of ASAP1 is important for regulating actin filament organization.	Lysine	60-66	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	103-108
35371306-5	2022	In addition, we found that DDX21 directly recruited WDR5 to enhance trimethylation of histone H3 on Lys 4 (H3K4me3) on the CDK1 promoter.	Lysine	100-103	DExD-box helicase 21	Homo sapiens	27-32
35173149-9	2022	Overexpression of lncRNA ROR activated TESC by inhibiting the G9a recruitment on the promoter of TESC and histone H3-lysine 9me methylation.	Lysine	117-123	tescalcin	Homo sapiens	39-43
35165261-5	2022	Then, using a streptozotocin (STZ)-induced diabetic rat model, R28 cells and primary rat RGCs (rRGCs), we demonstrated that OPTN underwent lysine succinylation in the retinas of rats with DR and that OPTN K108su mediated autophagic flux blockade under high-glucose (HG) conditions.	Lysine	139-145	optineurin	Rattus norvegicus	124-128
35051687-7	2022	Substitution to lysine in D29K resulted in an increased number of hydrogen bonds in the T1R2 receptor, while substitution to alanine in R43A ablated a polar interaction in the T1R3 receptor.	Lysine	16-22	taste 1 receptor member 2	Homo sapiens	88-92
35110531-8	2022	OTUB2 mechanically stabilized KRT80 by deubiquitinating and shielding it from proteasome-mediated degradation through Lys-48 and Lys-63.	Lysine	118-121	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	0-5
35110531-8	2022	OTUB2 mechanically stabilized KRT80 by deubiquitinating and shielding it from proteasome-mediated degradation through Lys-48 and Lys-63.	Lysine	129-132	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	0-5
35108527-2	2022	Here, we provide evidence that this phenomenon is partly due to an active program of gene silencing mediated by EZH2, a histone methyltransferase that generates repressive histone 3 lysine 27 trimethyl (H3K27me3) histone marks.	Lysine	182-188	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	112-116
35039641-4	2022	In naive CD4+ T cells, LINE1-containing transcripts are regulated by the transcription factor IRF4 and kept at chromatin by nucleolin; these transcripts act in cis, hampering levels of histone 3 (H3) lysine 36 trimethyl (H3K36me3) and stalling gene expression.	Lysine	200-206	CD4 antigen	Mus musculus	9-12
35039641-4	2022	In naive CD4+ T cells, LINE1-containing transcripts are regulated by the transcription factor IRF4 and kept at chromatin by nucleolin; these transcripts act in cis, hampering levels of histone 3 (H3) lysine 36 trimethyl (H3K36me3) and stalling gene expression.	Lysine	200-206	interferon regulatory factor 4	Mus musculus	94-98
35039641-4	2022	In naive CD4+ T cells, LINE1-containing transcripts are regulated by the transcription factor IRF4 and kept at chromatin by nucleolin; these transcripts act in cis, hampering levels of histone 3 (H3) lysine 36 trimethyl (H3K36me3) and stalling gene expression.	Lysine	200-206	nucleolin	Mus musculus	124-133
35039641-4	2022	In naive CD4+ T cells, LINE1-containing transcripts are regulated by the transcription factor IRF4 and kept at chromatin by nucleolin; these transcripts act in cis, hampering levels of histone 3 (H3) lysine 36 trimethyl (H3K36me3) and stalling gene expression.	Lysine	200-206	histocompatibility 3	Mus musculus	185-198
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	sequestosome 1	Homo sapiens	90-96
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	sequestosome 1	Homo sapiens	97-100
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	sequestosome 1	Homo sapiens	102-116
35100065-3	2022	Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization.	Lysine	170-176	sequestosome 1	Homo sapiens	195-201
34545936-5	2022	The transcript level of SOC1 is elevated in brm-3, gnc, and brm-3/gnc mutants, which is associated with increased histone H3 lysine 4 tri-methylation (H3K4Me3) but decreased DNA methylation levels.	Lysine	125-131	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	66-69
35046516-7	2022	The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1, decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50, which promotes the formation of the PRMT5-Mep50 octamer.	Lysine	45-51	sirtuin 7	Homo sapiens	4-9
20424159-4	2010	We show that E1 transfers SUMO from its thioester directly to lysine residues on Ubc9, forming isopeptide linkages.	Lysine	62-68	ubiquitin-conjugating enzyme E2I	Mus musculus	81-85
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Lysine	244-247	EcoRII restriction enzyme	Escherichia coli	33-39
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Lysine	244-247	EcoRII restriction enzyme	Escherichia coli	130-136
20111963-18	2010	Therefore, [Lys(40)((68)Ga-DOTA)]exendin-3 is a promising tracer to visualize insulinomas with PET.	Lysine	12-15	thyroid stimulating hormone receptor	Mus musculus	95-98
10801882-6	2000	We determined that the epitope resides within a region of seven amino acids on the alpha-helix 2B domain of keratin 18 in which two amino acids (Leu(366) and Lys(370)) are completely conserved among intermediate filaments as well as other keratin members that are immunoreactive with RS-11.	Lysine	158-161	keratin 18	Homo sapiens	108-118
20418916-0	2010	LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription.	Lysine	42-48	lysine demethylase 1A	Homo sapiens	0-4
10936206-7	2000	Supporting the in vivo relevance of this observation, endogenous paired helical filament-tau isolated from subjects with Alzheimer"s disease was immunoreactive with an antibody to a stable HNE-lysine adduct, as were all vulnerable neurons in subjects with Alzheimer"s disease but not in control individuals.	Lysine	193-199	microtubule associated protein tau	Homo sapiens	89-92
20418916-2	2010	We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3.	Lysine	46-52	lysine demethylase 1A	Homo sapiens	75-79
20418916-2	2010	We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3.	Lysine	119-125	lysine demethylase 1A	Homo sapiens	75-79
20577214-8	2010	S1P, but not dihydro-S1P, markedly increased recombinant TRAF2-catalysed lysine-63-linked, but not lysine-48-linked, polyubiquitination of RIP1 in vitro in the presence of the ubiquitin conjugating enzymes (E2) UbcH13 or UbcH5a.	Lysine	73-79	TNF receptor associated factor 2	Homo sapiens	57-62
20577214-9	2010	Our data show that TRAF2 is a novel intracellular target of S1P, and that S1P is the missing cofactor for TRAF2 E3 ubiquitin ligase activity, indicating a new paradigm for the regulation of lysine-63-linked polyubiquitination.	Lysine	190-196	TNF receptor associated factor 2	Homo sapiens	19-24
20577214-9	2010	Our data show that TRAF2 is a novel intracellular target of S1P, and that S1P is the missing cofactor for TRAF2 E3 ubiquitin ligase activity, indicating a new paradigm for the regulation of lysine-63-linked polyubiquitination.	Lysine	190-196	TNF receptor associated factor 2	Homo sapiens	106-111
11052891-0	2000	Interaction of myosin LYS-553 with the C-terminus and DNase I-binding loop of actin examined by fluorescence resonance energy transfer.	Lysine	22-25	myosin heavy chain 14	Homo sapiens	15-21
20346425-5	2010	We found that Lys(94) and Lys(141) of SART1 were preferentially conjugated to SUMO-2 monomers and multimers in vitro.	Lysine	14-17	small ubiquitin like modifier 2	Homo sapiens	78-84
20346425-5	2010	We found that Lys(94) and Lys(141) of SART1 were preferentially conjugated to SUMO-2 monomers and multimers in vitro.	Lysine	26-29	small ubiquitin like modifier 2	Homo sapiens	78-84
11052891-3	2000	The efficiency of energy transfer between the acceptor molecules at Lys-553 of myosin and donor probes at Cys-374 or Gln-41 of actin was calculated to be 0.78 +/- 0.01 or 0.94 +/- 0.01, respectively, corresponding to distances of 35.6 +/- 0.4 A and 24.0 +/- 1.6 A, respectively.	Lysine	68-71	myosin heavy chain 14	Homo sapiens	79-85
10816585-1	2000	In this study, we identified lysine residues in the fibrinogen Aalpha chain that serve as substrates during transglutaminase (TG)-mediated cross-linking of plasminogen activator inhibitor 2 (PAI-2).	Lysine	29-35	serpin family B member 2	Homo sapiens	156-189
20207735-5	2010	Purified recombinant ALDH7A1 efficiently metabolized a number of aldehyde substrates, including the osmolyte precursor, betaine aldehyde, lipid peroxidation-derived aldehydes, and the intermediate lysine degradation product, alpha-aminoadipic semialdehyde.	Lysine	197-203	aldehyde dehydrogenase 7 family member A1	Homo sapiens	21-28
10816585-1	2000	In this study, we identified lysine residues in the fibrinogen Aalpha chain that serve as substrates during transglutaminase (TG)-mediated cross-linking of plasminogen activator inhibitor 2 (PAI-2).	Lysine	29-35	serpin family B member 2	Homo sapiens	191-196
10816585-6	2000	Peptides detected were consistent with tissue TG (tTG)-mediated cross-linking of PAI-2 to lysines 148, 176, 183, 457 and factor XIIIa-mediated cross-linking of PAI-2 to lysines 148, 230, and 413 in the Aalpha chain.	Lysine	90-97	serpin family B member 2	Homo sapiens	81-86
20550940-4	2010	However, in contrast to previous results, we found modification of Rad17 to be independent of DNA damage, the Rad6-Rad18 complex, the putative acceptor site (lysine 197), and loading of the complex onto DNA.	Lysine	158-164	Rad17p	Saccharomyces cerevisiae S288C	67-72
10816585-6	2000	Peptides detected were consistent with tissue TG (tTG)-mediated cross-linking of PAI-2 to lysines 148, 176, 183, 457 and factor XIIIa-mediated cross-linking of PAI-2 to lysines 148, 230, and 413 in the Aalpha chain.	Lysine	169-176	serpin family B member 2	Homo sapiens	160-165
11003134-3	2000	These analogues were designed looking for suppressors of EAE induced by guinea pig MBP(72-85) epitope (Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-Pro-Val) in Lewis rats.	Lysine	107-110	myelin basic protein	Cavia porcellus	83-86
20308065-3	2010	Here we demonstrated that the expression of TPPP/p25 in HeLa cells, in doxycycline-inducible CHO10 cells, and in the oligodendrocyte CG-4 cells promoted the acetylation of alpha-tubulin at residue Lys-40, whereas its down-regulation by specific small interfering RNA in CG-4 cells or by the withdrawal of doxycycline from CHO10 cells decreased the acetylation level of alpha-tubulin.	Lysine	197-200	tubulin polymerization promoting protein	Homo sapiens	44-52
20398676-8	2010	The interaction between ACT1 and ACT4 or between ACT2 and ACT3 generates a threonine binding site and a lysine binding site at each interface, making a total of eight regulatory sites per dimer and allowing a fine-tuning of the AK activity by the end products, threonine and lysine.	Lysine	104-110	TRAF3 interacting protein 2	Homo sapiens	24-28
20398676-8	2010	The interaction between ACT1 and ACT4 or between ACT2 and ACT3 generates a threonine binding site and a lysine binding site at each interface, making a total of eight regulatory sites per dimer and allowing a fine-tuning of the AK activity by the end products, threonine and lysine.	Lysine	275-281	TRAF3 interacting protein 2	Homo sapiens	24-28
10791961-1	2000	Cytochromes c from plants and fungi, but not higher animals, contain methylated lysine residues at specific positions, including for example, the trimethylated lysine at position 72 in iso-1-cytochrome c of the yeast Saccharomyces cerevisiae.	Lysine	80-86	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
20498884-2	2010	FcCD inclusive complex and glucose oxidase (GOx) were covalently bonded to CNTs by poly-l-lysine (PLL) to fabricate a glucose biosensor.	Lysine	83-96	hydroxyacid oxidase 1	Homo sapiens	27-42
20498884-2	2010	FcCD inclusive complex and glucose oxidase (GOx) were covalently bonded to CNTs by poly-l-lysine (PLL) to fabricate a glucose biosensor.	Lysine	83-96	hydroxyacid oxidase 1	Homo sapiens	44-47
10791961-1	2000	Cytochromes c from plants and fungi, but not higher animals, contain methylated lysine residues at specific positions, including for example, the trimethylated lysine at position 72 in iso-1-cytochrome c of the yeast Saccharomyces cerevisiae.	Lysine	80-86	cytochrome c, somatic	Equus caballus	191-203
10791961-1	2000	Cytochromes c from plants and fungi, but not higher animals, contain methylated lysine residues at specific positions, including for example, the trimethylated lysine at position 72 in iso-1-cytochrome c of the yeast Saccharomyces cerevisiae.	Lysine	160-166	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
20152941-4	2010	In human Pg (hPg), K2 displays weak Lys affinity, however the LBS of this domain has been implicated in an atypical interaction with the N-terminal region of a bacterial surface protein known as PAM (Pg-binding group A streptococcal M-like protein).	Lysine	36-39	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	200-247
10791961-1	2000	Cytochromes c from plants and fungi, but not higher animals, contain methylated lysine residues at specific positions, including for example, the trimethylated lysine at position 72 in iso-1-cytochrome c of the yeast Saccharomyces cerevisiae.	Lysine	160-166	cytochrome c, somatic	Equus caballus	191-203
10869174-2	2000	The structure displays the same folding and detailed features as turnip cytochrome f, including (a) an unusual heme Fe ligation by the alpha-amino group of tyrosine 1, (b) a cluster of lysine residues (proposed docking site of plastocyanin), and (c) the presence of a chain of seven water molecules bound to conserved residues and extending between the heme pocket and K58 and K66 at the lysine cluster.	Lysine	185-191	cytochrome f	Chlamydomonas reinhardtii	72-84
20451370-2	2010	We hypothesized that SCLC chemotherapy could be improved by using histone deacetylase (HDAC) inhibitors based on their ability to interfere with lysine acetylation and to alter gene expression.	Lysine	145-151	histone deacetylase 9	Homo sapiens	66-85
10869174-2	2000	The structure displays the same folding and detailed features as turnip cytochrome f, including (a) an unusual heme Fe ligation by the alpha-amino group of tyrosine 1, (b) a cluster of lysine residues (proposed docking site of plastocyanin), and (c) the presence of a chain of seven water molecules bound to conserved residues and extending between the heme pocket and K58 and K66 at the lysine cluster.	Lysine	388-394	cytochrome f	Chlamydomonas reinhardtii	72-84
20451370-2	2010	We hypothesized that SCLC chemotherapy could be improved by using histone deacetylase (HDAC) inhibitors based on their ability to interfere with lysine acetylation and to alter gene expression.	Lysine	145-151	histone deacetylase 9	Homo sapiens	87-91
10842153-10	2000	LY 294002 inhibited TSP-1-, Fn-, and Vn-stimulated VSMC migration (85% to 89%, P &lt;.05).	Lysine	0-2	thrombospondin 1	Bos taurus	20-25
20485450-6	2010	The affected amino acid was located at residue 40 of the mature GABRG2 protein, which was near the first one of two high-affinity benzodiazepine-binding domains of the gamma2 subunit (Lys-41-Trp-82).	Lysine	184-187	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	64-70
10842153-10	2000	LY 294002 inhibited TSP-1-, Fn-, and Vn-stimulated VSMC migration (85% to 89%, P &lt;.05).	Lysine	0-2	fibronectin 1	Bos taurus	28-30
10850706-7	2000	Most contacts in the complex are between KIR and conserved HLA-C residues, but a hydrogen bond between Lys 44 of KIR2DL2 and Asn 80 of Cw3 confers the allotype specificity.	Lysine	103-106	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	113-120
20351170-2	2010	The SUMO E3 ligase PIAS1 enhances SUMO conjugation to SATB1 lysine-744, and this modification regulates caspase-6 mediated cleavage of SATB1 at promyelocytic leukemia nuclear bodies (PML NBs).	Lysine	60-66	SATB homeobox 1	Homo sapiens	54-59
10860643-4	2000	Examination of brachiopod codons corresponding to invariant amino acids in the COI of various other animals suggest the nonuniversal codon relationships UGA = Trp, AUA = Met, AAA/G = Lys, and AGA/G = Ser.	Lysine	183-186	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	79-82
20307995-2	2010	This mutation results from the substitution of asparagine (AAC) by lysine (AAA) at codon 103 of a non-mature (signal peptide-containing) leptin and corresponds to the N82K mutation in the mature protein.	Lysine	67-73	glycine-N-acyltransferase	Homo sapiens	59-62
10892349-7	2000	TIP30/CC3 contains characteristic motifs at the catalytic site of SDRs, including a serine, tyrosine, and lysine that are important in catalyzing hydride transfer between substrate and cofactor.	Lysine	106-112	HIV-1 Tat interactive protein 2	Homo sapiens	0-5
20363855-4	2010	In striking contrast to the developmental pleiotropy conferred by mutation in other plant Paf1C component genes in Arabidopsis, loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C. Those genes targeted by PHP were distinguished from the bulk of Arabidopsis genes and other plant Paf1C targets by strong enrichment for trimethylation of lysine-27 on histone H3 (H3K27me3) within chromatin.	Lysine	506-512	PLANT HOMOLOGOUS TO PARAFIBROMIN	Arabidopsis thaliana	136-139
20228053-5	2010	Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue within the BRCA1 C-terminal domain of PARP1 (lysine 482) as its primary SUMOylation site.	Lysine	144-150	poly(ADP-ribose) polymerase 1 L homeolog	Xenopus laevis	68-73
20228053-5	2010	Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue within the BRCA1 C-terminal domain of PARP1 (lysine 482) as its primary SUMOylation site.	Lysine	144-150	breast cancer 1 L homeolog	Xenopus laevis	110-115
10892349-7	2000	TIP30/CC3 contains characteristic motifs at the catalytic site of SDRs, including a serine, tyrosine, and lysine that are important in catalyzing hydride transfer between substrate and cofactor.	Lysine	106-112	HIV-1 Tat interactive protein 2	Homo sapiens	6-9
20228053-5	2010	Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue within the BRCA1 C-terminal domain of PARP1 (lysine 482) as its primary SUMOylation site.	Lysine	144-150	poly(ADP-ribose) polymerase 1 L homeolog	Xenopus laevis	137-142
10810230-2	2000	To test the hypothesis that inhibiting the formation of glycated albumin might beneficially influence the development of kidney disease in diabetes, we treated diabetic db/db mice for 12 weeks with a low-molecular-weight compound (EXO-226) that impedes the condensation of free glucose with lysine epsilon-amino groups in albumin.	Lysine	291-297	5'-3' exoribonuclease 1	Mus musculus	231-234
10850803-7	2000	Substitutions of the lysine at equivalent positions in two other inhibitory serpins, human alpha1-antichymotrypsin and human antithrombin III, also increased stability and decreased inhibitory activity toward alpha-chymotrypsin and thrombin, respectively.	Lysine	21-27	serpin family C member 1	Homo sapiens	125-141
20463296-3	2010	Ash2l is the mammalian homolog of Drosophila Ash2 (absent small homeotic 2) and is a core component of a multimeric histone methyltransferase complex that epigenetically regulates transcription via methylation of histone lysine residues.	Lysine	221-227	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	0-5
20463296-3	2010	Ash2l is the mammalian homolog of Drosophila Ash2 (absent small homeotic 2) and is a core component of a multimeric histone methyltransferase complex that epigenetically regulates transcription via methylation of histone lysine residues.	Lysine	221-227	absent, small, or homeotic discs 2	Drosophila melanogaster	0-4
10823273-0	2000	Vitronectin and substitution of a beta-strand 5A lysine residue potentiate activity-neutralization of PA inhibitor-1 by monoclonal antibodies against alpha-helix F. Some monoclonal antibodies against plasminogen activator inhibitor-1 (PAI-1) are able to inhibit its reaction with its target proteinases.	Lysine	49-55	serpin family E member 1	Homo sapiens	200-233
20147392-4	2010	Overexpression of APOBEC3G or lysine-free APOBEC3G stabilized HIV-1 Vif, indicating that APOBEC3G degradation is independent of the degradation of Vif.	Lysine	30-36	Vif	Human immunodeficiency virus 1	68-71
20194622-0	2010	Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.	Lysine	20-26	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	81-86
20194622-6	2010	Changes to these core residues altered the lysine preference of Cdc34 and specified whether this enzyme monoubiquitinated or polyubiquitinated Sic1.	Lysine	43-49	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	64-69
10766996-4	2000	The DNA sequencing demonstrated novel mutations in exon 3A of AT3: a G to T substitution at nucleotide position 5333 in codon GAG for Glu 113, causing a stop codon (E113X), and an A to T substitution at position 5338 in codon AAA for Lys 114, forming Asn (K114N).	Lysine	234-237	serpin family C member 1	Homo sapiens	62-65
20404557-4	2010	We recently reported that UBC13, the only known ubiquitin conjugase capable of catalyzing Lys 63-linked polyubiqitination, is responsive to the iron (Fe) regime at the post-transcriptional level and may play a crucial role for the morphological alterations triggered by Fe deficiency in cucumber and Arabidopsis roots.	Lysine	90-93	ubiquitin-conjugating enzyme E2 35-like	Cucumis sativus	26-31
10760305-5	2000	hot1 was found to have a mutation in the heat shock protein 101 (Hsp101) gene, converting a conserved Glu residue in the second ATP-binding domain to a Lys residue, a mutation that is predicted to compromise Hsp101 ATPase activity.	Lysine	152-155	heat shock protein 101	Arabidopsis thaliana	0-4
20501910-7	2010	Our results aid in the elucidation of the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route.	Lysine	59-62	electron-transfer flavoprotein:ubiquinone oxidoreductase	Arabidopsis thaliana	222-227
10803659-1	2000	A 9-base-pair (bp) deletion located between the lysine tRNA (MTTK) and COII (MTCOX*2) genes in the human mitochondrial genome is a valuable marker for tracing population relationships.	Lysine	48-54	mitochondrially encoded tRNA lysine	Homo sapiens	61-65
20442859-3	2010	However, using a combination of genetic, biochemical and morphological methodologies, we find that CD4 degradation induced by Vpu is dependent on a key component of the ERAD machinery, the VCP-UFD1L-NPL4 complex, as well as on SCF(beta-TrCP)-dependent ubiquitination of the CD4 cytosolic tail on lysine and serine/threonine residues.	Lysine	296-302	Vpu	Human immunodeficiency virus 1	126-129
10694430-10	2000	A lysine to arginine mutation abolished MITF (K201R) degradation by hUBC9 in vivo.	Lysine	2-8	melanocyte inducing transcription factor	Homo sapiens	40-44
20403326-3	2010	Activation of RIG-I requires not only RNA but also polyubiquitin chains linked through lysine 63 (K63) of ubiquitin.	Lysine	87-93	DExD/H-box helicase 58	Homo sapiens	14-19
10660118-8	2000	Reversible beta-AR agonists such as (-)-isoproterenol, BRL 37344, and 4"-acetamido-3",5"-diiodoTMQ or nucleophilic 1-amino acids (lysine, glutathione, cysteine) did not protect against this irreversible binding.	Lysine	130-136	adrenoceptor beta 3	Homo sapiens	11-18
20379885-1	2010	A putative causative mutation underlying a QTL was identified as a lysine to alanine non-conservative substitution at amino acid 232 of the gene encoding the acylCoA:diacylglycerol acyltransferase (DGAT1) protein.	Lysine	67-73	diacylglycerol O-acyltransferase 1	Bos taurus	198-203
10688618-6	2000	Substitution of phenylalanine with lysine at the hH1-F1760 position, a putative binding site for local anesthetics, eliminates the use-dependent block by amitriptyline at 1 microM.	Lysine	35-41	H1.5 linker histone, cluster member	Homo sapiens	49-52
20305384-2	2010	Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a (which methylates histone H3 on lysine 9), the relationship between DNA methylation and repressive histone marks has not been fully studied.	Lysine	137-143	euchromatic histone lysine methyltransferase 2	Homo sapiens	152-155
20305384-2	2010	Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a (which methylates histone H3 on lysine 9), the relationship between DNA methylation and repressive histone marks has not been fully studied.	Lysine	188-194	euchromatic histone lysine methyltransferase 2	Homo sapiens	152-155
20071582-10	2010	Our results indicate that Thr-170 phosphorylation and TRIM25-mediated Lys-172 ubiquitination of RIG-I functionally antagonize each other.	Lysine	70-73	DExD/H-box helicase 58	Homo sapiens	96-101
20071582-11	2010	While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction.	Lysine	50-53	DExD/H-box helicase 58	Homo sapiens	81-86
10681457-4	2000	A dual analog (termed Lys-262-Ala-207) composed of the tandemly arranged two single amino acid analogs of p195-212 and p259-271 was shown to inhibit, in vitro and in vivo, MG-associated autoimmune responses.	Lysine	22-25	transmembrane protein 45a	Mus musculus	106-110
20334638-0	2010	Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.	Lysine	28-34	H1.0 linker histone	Homo sapiens	0-10
20334638-0	2010	Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.	Lysine	28-34	euchromatic histone lysine methyltransferase 2	Homo sapiens	54-59
20334638-5	2010	We found that the histone lysine methyltransferases G9a/KMT1C and Glp1/KMT1D methylate H1.2 in vitro and in vivo, and we mapped this novel site to lysine 187 (H1.2K187) in the C-terminus of H1.	Lysine	26-32	euchromatic histone lysine methyltransferase 2	Homo sapiens	56-61
10882077-3	2000	We demonstrate that MOF, a protein required for dosage compensation with significant sequence similarity to the MYST family of acetyltransferases, is a histone acetyltransferase that acetylates chromatin specifically at histone H4 lysine 16.	Lysine	231-237	males absent on the first	Drosophila melanogaster	20-23
20226045-5	2010	Within the C-terminal domain of IN, four lysines (K258, K264, K266, and K273) are targeted by GCN5 acetylation, three of which (K264, K266, and K273) are also modified by p300.	Lysine	41-48	lysine acetyltransferase 2A	Homo sapiens	94-98
20226045-6	2010	Replication analysis of HIV-1 clones carrying substitutions at the IN lysines acetylated by both GCN5 and p300, or exclusively by GCN5, demonstrated that these residues are required for efficient viral integration.	Lysine	70-77	lysine acetyltransferase 2A	Homo sapiens	97-101
20226045-7	2010	In addition, a comparative analysis of the replication efficiencies of the IN triple- and quadruple-mutant viruses revealed that even though the lysines targeted by both GCN5 and p300 are required for efficient virus integration, the residue exclusively modified by GCN5 (K258) does not affect this process.	Lysine	145-152	lysine acetyltransferase 2A	Homo sapiens	170-174
10656693-3	2000	The acetylation sites in vivo have been located at the lysine residues of the conserved domain (K471, K480, K485) by the use of the mutant Myb (Myb-KAmut), in which all three lysine residues are substituted into alanine.	Lysine	175-181	MYB proto-oncogene, transcription factor	Homo sapiens	139-142
20148560-1	2010	LSD1 is a flavin-dependent histone demethylase that oxidatively removes methyl groups from Lys-4 of histone H3.	Lysine	91-94	lysine demethylase 1A	Homo sapiens	0-4
20051513-0	2010	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	Lysine	0-6	solute carrier family 6 member 3	Homo sapiens	43-63
20051513-0	2010	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	Lysine	0-6	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	96-103
20051513-8	2010	Analysis of DAT ubiquitination using polyubiquitin chain-specific antibodies showed that DAT is mainly conjugated with Lys(63)-linked ubiquitin chains.	Lysine	119-122	solute carrier family 6 member 3	Homo sapiens	89-92
10656693-3	2000	The acetylation sites in vivo have been located at the lysine residues of the conserved domain (K471, K480, K485) by the use of the mutant Myb (Myb-KAmut), in which all three lysine residues are substituted into alanine.	Lysine	175-181	MYB proto-oncogene, transcription factor	Homo sapiens	144-147
10615072-6	2000	Phosphorylation of H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH (BPDEtide), a specific substrate for PKG, measured the activity of cGMP-dependent protein kinase (PKG).	Lysine	25-28	protein kinase cGMP-dependent 1	Homo sapiens	113-116
20051513-10	2010	The model is proposed whereby each ubiquitinated DAT molecule is modified by a single four-ubiquitin Lys(63)-linked chain that can be conjugated to various lysine residues of DAT.	Lysine	101-104	solute carrier family 6 member 3	Homo sapiens	49-52
20051513-10	2010	The model is proposed whereby each ubiquitinated DAT molecule is modified by a single four-ubiquitin Lys(63)-linked chain that can be conjugated to various lysine residues of DAT.	Lysine	101-104	solute carrier family 6 member 3	Homo sapiens	175-178
20051513-10	2010	The model is proposed whereby each ubiquitinated DAT molecule is modified by a single four-ubiquitin Lys(63)-linked chain that can be conjugated to various lysine residues of DAT.	Lysine	156-162	solute carrier family 6 member 3	Homo sapiens	49-52
10615072-6	2000	Phosphorylation of H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH (BPDEtide), a specific substrate for PKG, measured the activity of cGMP-dependent protein kinase (PKG).	Lysine	25-28	protein kinase cGMP-dependent 1	Homo sapiens	174-177
20051513-10	2010	The model is proposed whereby each ubiquitinated DAT molecule is modified by a single four-ubiquitin Lys(63)-linked chain that can be conjugated to various lysine residues of DAT.	Lysine	156-162	solute carrier family 6 member 3	Homo sapiens	175-178
11430491-7	2000	Drosophila Nop56p proteins contain lysine-rich regions at their carboxy-terminus, and show a high degree of similarity to other Nop56p proteins from different organisms.	Lysine	35-41	Nop56	Drosophila melanogaster	11-17
20641826-6	2004	To generate (99m)Tc-HYNIC-annexin A5, the conjugation of HYNIC to annexin A5 is achieved by non-specifically directing HYNIC to an amino group on one of the 21 lysine residues in the protein structure, and any one of the lysine residues may bind the conjugating agent resulting in the formation of a molecule with an uncertain structure.	Lysine	160-166	annexin A5	Mus musculus	66-76
20641826-6	2004	To generate (99m)Tc-HYNIC-annexin A5, the conjugation of HYNIC to annexin A5 is achieved by non-specifically directing HYNIC to an amino group on one of the 21 lysine residues in the protein structure, and any one of the lysine residues may bind the conjugating agent resulting in the formation of a molecule with an uncertain structure.	Lysine	221-227	annexin A5	Mus musculus	66-76
11021404-0	2000	Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N. Carboxypeptidase R (EC 3.4.17.20) (CPR) and carboxypeptidase N (EC 3.4.17.3) (CPN) cleave carboxy-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.	Lysine	219-225	carboxypeptidase B2	Rattus norvegicus	100-118
20036705-8	2010	The genotype 2DL2+/HLA-C lys(80)+ was also more common in controls (IBD: p = 0.005; UC: p = 0.01; CD: p = NS); as well as 2DL1+/HLA-C Asn(80)+ (IBD: p = 0.026; UC: p = NS;CD: p = NS).	Lysine	25-28	major histocompatibility complex, class I, C	Homo sapiens	19-24
20036705-8	2010	The genotype 2DL2+/HLA-C lys(80)+ was also more common in controls (IBD: p = 0.005; UC: p = 0.01; CD: p = NS); as well as 2DL1+/HLA-C Asn(80)+ (IBD: p = 0.026; UC: p = NS;CD: p = NS).	Lysine	25-28	major histocompatibility complex, class I, C	Homo sapiens	128-133
10601236-2	1999	We previously demonstrated that a variant of TCRalpha lacking lysines (KalphaR) is degraded by this pathway with kinetics indistinguishable from those of the wild type protein (Yu, H., Kaung, G., Kobayashi, S., and Kopito, R. R. (1997) J. Biol.	Lysine	62-69	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	45-53
19800007-5	2010	Most of the VEK-30/K2(Pg) interactions in solution occur between a single face of the alpha-helix of VEK-30 and the lysine binding site (LBS) of K2(Pg).	Lysine	116-122	RBPJ pseudogene 3	Homo sapiens	19-25
10642839-2	1999	We investigated the hypothesis that excessive deposition of epsilon-(gamma-glutamyl)lysine bonds is a neuropathological mechanism which induces the polymerization of tau protein into stable aggregates leading to the formation of paired helical filaments (PHFs) which deposit into neurofibrillary tangles in Alzheimer"s disease (AD) brain.	Lysine	84-90	microtubule associated protein tau	Homo sapiens	166-169
19800007-5	2010	Most of the VEK-30/K2(Pg) interactions in solution occur between a single face of the alpha-helix of VEK-30 and the lysine binding site (LBS) of K2(Pg).	Lysine	116-122	RBPJ pseudogene 3	Homo sapiens	145-151
19800007-6	2010	The canonical LBS of K2(Pg), consisting of Asp54, Asp56, Trp60, Arg69, and Trp70 (kringle numbering), interacts with an internal pseudo-lysine of VEK-30, comprising side-chains of Arg17, His18, and Glu20.	Lysine	136-142	RBPJ pseudogene 3	Homo sapiens	21-27
10642839-4	1999	In vivo, PHF tau, and high and medium molecular weight neurofilament proteins have significantly greater cross-linking by epsilon-(gamma-glutamyl)lysine bonds in AD brains as compared to controls.	Lysine	146-152	microtubule associated protein tau	Homo sapiens	9-16
20133625-1	2010	HYPB is a human histone H3 lysine 36 (H3K36)-specific methyltransferase and acts as the ortholog of yeast Set2.	Lysine	27-33	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	106-110
10567240-1	1999	Lysine-oxoglutarate reductase and saccharopine dehydrogenase are enzymic activities that catalyse the first two steps of lysine degradation through the saccharopine pathway in upper eukaryotes.	Lysine	121-127	aminoadipate-semialdehyde synthase	Mus musculus	0-29
20051228-3	2010	The resulting divergent promoter region is bound by the chromatin insulator protein CTCF in association with histone H3 tri-methylated on lysine 4, irrespective of transcription of ANRIL and ARF.	Lysine	138-144	CCCTC-binding factor	Homo sapiens	84-88
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	241-244	cAMP responsive element binding protein 1	Homo sapiens	66-70
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	241-244	lysine acetyltransferase 2A	Homo sapiens	174-178
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cAMP responsive element binding protein 1	Homo sapiens	66-70
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	lysine acetyltransferase 2A	Homo sapiens	174-178
10567240-1	1999	Lysine-oxoglutarate reductase and saccharopine dehydrogenase are enzymic activities that catalyse the first two steps of lysine degradation through the saccharopine pathway in upper eukaryotes.	Lysine	121-127	aminoadipate-semialdehyde synthase	Mus musculus	34-60
10567240-9	1999	Lysine-injected mice also show an increase in lysine-oxoglutarate reductase and saccharopine dehydrogenase levels.	Lysine	0-6	aminoadipate-semialdehyde synthase	Mus musculus	46-75
10567240-9	1999	Lysine-injected mice also show an increase in lysine-oxoglutarate reductase and saccharopine dehydrogenase levels.	Lysine	0-6	aminoadipate-semialdehyde synthase	Mus musculus	80-106
10607407-9	1999	Both amino acid sequencing and compositional analysis identified Lys-306 as the site of o-phthalaldehyde binding within the brain GDH isoproteins.	Lysine	65-68	glutamate dehydrogenase 1	Homo sapiens	130-133
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cAMP responsive element binding protein 1	Homo sapiens	66-70
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	lysine acetyltransferase 2A	Homo sapiens	174-178
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	cAMP responsive element binding protein 1	Homo sapiens	66-70
20074040-4	2010	The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general control non-derepressible 5)] acetylates cyclin A at Lys(54), Lys(68), Lys(95) and Lys(112) during mitosis, leading to its ubiquitylation by the anaphase-promoting factor/cyclosome and its subsequent degradation via proteasome.	Lysine	250-253	lysine acetyltransferase 2A	Homo sapiens	174-178
10585950-2	1999	Lys(16) was demonstrated to be crucial to the function of Ras p21, and the hydrolysis of GTP to GDP was found to be an one-step reaction.	Lysine	0-3	H3 histone pseudogene 16	Homo sapiens	62-65
19285668-0	2010	Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development.	Lysine	26-32	LOC102641229	Mus musculus	39-49
10625451-2	1999	To examine the surface of IGF-I that associates with the IGFBPs, we created a series of six IGF-I analogues, [His(4)]-, [Gln(9)]-, [Lys(9)]-, [Ser(16)]-, [Gln(9),Ser(16)]-, and [Lys(9),Ser(16)]IGF-I, that contained substitutions for residues Thr(4), Glu(9), or Phe(16).	Lysine	132-135	insulin-like growth factor 1	Rattus norvegicus	26-31
19819898-8	2010	The dual characteristics of chymosin are due to the occurrence of polar/charged residues in the S1" subsite, such as Glu/Asp(289), Gln(298) and Lys/Gln(299), which are different from the S1" subsite of pepsin A.	Lysine	144-147	pepsin A	Bos taurus	202-210
10625451-2	1999	To examine the surface of IGF-I that associates with the IGFBPs, we created a series of six IGF-I analogues, [His(4)]-, [Gln(9)]-, [Lys(9)]-, [Ser(16)]-, [Gln(9),Ser(16)]-, and [Lys(9),Ser(16)]IGF-I, that contained substitutions for residues Thr(4), Glu(9), or Phe(16).	Lysine	178-181	insulin-like growth factor 1	Rattus norvegicus	26-31
10589788-5	1999	Purified K1-3 protein is apparently folded in an active conformation, as evidenced by its ability to bind to lysine-Sepharose.	Lysine	109-115	keratin 13	Homo sapiens	9-13
20086207-5	2010	In addition, the 3D structural model of integrin alpha(v)beta(3) was generated according to the crystal structure of the integrin alpha(v)beta(3) complex, and the molecular docking simulation analyses revealed that the predicted binding sites for the most active cyclopeptide c-Lys were consistent with the reported structure.	Lysine	278-281	integrin subunit alpha V	Homo sapiens	40-64
20086207-5	2010	In addition, the 3D structural model of integrin alpha(v)beta(3) was generated according to the crystal structure of the integrin alpha(v)beta(3) complex, and the molecular docking simulation analyses revealed that the predicted binding sites for the most active cyclopeptide c-Lys were consistent with the reported structure.	Lysine	278-281	integrin subunit alpha V	Homo sapiens	121-145
10624568-9	1999	These data suggest that a strategy for development of therapeutic agents for APS may be based on the use of small cyclic, organic oligoanions such as inositol derivatives to act as ligands for lysine residues at the PL binding site of beta 2GPI.	Lysine	193-199	apolipoprotein H	Homo sapiens	235-244
20043883-0	2010	Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression.	Lysine	26-32	solute carrier family 2 (facilitated glucose transporter), member 5	Mus musculus	42-48
10591082-8	1999	Immunohistochemical studies of mucosal biopsies from the bronchi of aspirin-intolerant asthmatics show that LTC4S is overrepresented in individuals with this phenotype, and this finding correlates with overproduction of cysteinyl leukotrienes and lysine-aspirin bronchial hyperreactivity.	Lysine	247-253	leukotriene C4 synthase	Homo sapiens	108-113
20102634-5	2010	The activity required two conserved phospho-serines in the cytoplasmic tail of Vpu that are known to recruit beta TrCP, a substrate adaptor for an SCF E3 ubiquitin ligase complex, and could be blocked by mutation of lysine 618 in the GaLV Env tail.	Lysine	216-222	Vpu	Human immunodeficiency virus 1	79-82
20102634-5	2010	The activity required two conserved phospho-serines in the cytoplasmic tail of Vpu that are known to recruit beta TrCP, a substrate adaptor for an SCF E3 ubiquitin ligase complex, and could be blocked by mutation of lysine 618 in the GaLV Env tail.	Lysine	216-222	hypothetical protein	Gibbon ape leukemia virus	239-242
19913553-3	2010	Here, we study one facet of this CHIP-mediated turnover by determining the lysine residues on human Hsp70 and Hsp90 ubiquitinated by CHIP.	Lysine	75-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	100-105
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Lysine	221-227	lysine acetyltransferase 2A	Homo sapiens	126-156
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Lysine	221-227	lysine acetyltransferase 2A	Homo sapiens	158-192
10521423-5	1999	Mutation of Lys-129, analogous to Lys-241 of yOgg1, abolishes glycosylase activity.	Lysine	12-15	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	45-50
10521423-5	1999	Mutation of Lys-129, analogous to Lys-241 of yOgg1, abolishes glycosylase activity.	Lysine	34-37	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	45-50
10491211-5	1999	The other mutation is an A--&gt;T transition at nucleotide 154, leading to the substitution of a lysine residue by a STOP codon (K52X) predicting premature termination of the precursor cathepsin K polypeptide.	Lysine	97-103	cathepsin K	Homo sapiens	185-196
20045648-5	2010	We have taken advantage of the amino acid difference between the BACE1 and BACE2 at the S2" pocket (BACE1 Pro(70) changed to BACE2 Lys(86)) to build ligands with &gt;500-fold selectivity against BACE2.	Lysine	131-134	beta-secretase 2	Homo sapiens	75-80
20045648-5	2010	We have taken advantage of the amino acid difference between the BACE1 and BACE2 at the S2" pocket (BACE1 Pro(70) changed to BACE2 Lys(86)) to build ligands with &gt;500-fold selectivity against BACE2.	Lysine	131-134	beta-secretase 2	Homo sapiens	125-130
10464296-9	1999	These findings, together with those on the crystal structure of estrogen sulfotransferase and heparan sulfate N-deacetylase/sulfotransferase, suggest that Lys(128) may be close to the 3-hydroxyl group of beta-glucuronic acid in a HNK-1 acceptor.	Lysine	155-158	sulfotransferase family 1E member 1	Homo sapiens	64-89
20045648-5	2010	We have taken advantage of the amino acid difference between the BACE1 and BACE2 at the S2" pocket (BACE1 Pro(70) changed to BACE2 Lys(86)) to build ligands with &gt;500-fold selectivity against BACE2.	Lysine	131-134	beta-secretase 2	Homo sapiens	125-130
20064247-3	2010	RESULTS: In this study, we describe that site-specific mutation of p65 at lysines 314 and 315 enhances gene expression of a subset of NF-kappaB target genes including Mmp10 and Mmp13.	Lysine	74-81	matrix metallopeptidase 10	Homo sapiens	167-172
20080798-0	2010	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.	Lysine	60-66	lysine demethylase 2A	Homo sapiens	32-38
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	lysine demethylase 2A	Homo sapiens	241-281
20080798-2	2010	We describe a NF-kappaB regulatory pathway that is driven by reversible lysine methylation of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protein 11 (FBXL11).	Lysine	72-78	lysine demethylase 2A	Homo sapiens	283-289
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Lysine	49-55	cytochrome b5 type A	Homo sapiens	248-263
21189691-6	2010	Sam68 frequently contains post-translational modifications including serine/threonine, tyrosine phosphorylation, lysine acetylation, arginine methylation and sumoylation.	Lysine	113-119	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
10553576-3	1999	ATP, produced by glucose metabolism, competes with cADPR for the binding site, Lys-129, of CD38, resulting in the inhibition of the hydrolysis of cADPR and thereby causing cADPR accumulation in beta-cells.	Lysine	79-82	CD38 molecule	Homo sapiens	91-95
20046830-11	2009	Nickel and hypoxia exposure significantly increased the levels of dimethylated H3 lysine 9 at the USP28 promoter and repressed its expression.	Lysine	82-88	ubiquitin specific peptidase 28	Homo sapiens	98-103
10419508-4	1999	ShK uses the same five core residues, all clustered around the critical Lys(22), to interact with IKCa1 and Kv1.3, although it relies on a larger number of contacts to stabilize its weaker interactions with IKCa1 than with Kv1.3.	Lysine	72-75	sedoheptulokinase	Homo sapiens	0-3
19784073-1	2009	Earlier, mapping of the 9p23-24 amplicon in esophageal cancer cell lines led us to the positional cloning of gene amplified in squamous cell carcinoma 1 (GASC1), which encodes a nuclear protein with a Jumonji C domain that catalyzes lysine (K) demethylation of histones.	Lysine	233-239	lysine demethylase 4C	Homo sapiens	154-159
19808672-3	2009	We identified CDYL1 as an interaction partner of histone H3 trimethylated on lysine 9 (H3K9me3).	Lysine	77-83	chromodomain Y like	Homo sapiens	14-19
19767775-0	2009	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.	Lysine	0-6	KIT ligand	Homo sapiens	60-63
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	KIT ligand	Homo sapiens	111-114
10400612-8	1999	Lys-97 and Arg-101 were absolutely required for hsp90 binding, while mutation of Arg-74 diminished, but did not abrogate, hsp90 binding.	Lysine	0-3	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-53
19920177-4	2009	First, Rsp5 adds mono-ubiquitin, or sometimes a ubiquitin chain linked via ubiquitin lysine 63 that does not trigger proteolysis.	Lysine	85-91	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	7-11
10400612-9	1999	Mutation of Lys-32, another conserved basic residue in the binding groove, also blocked hsp90 binding.	Lysine	12-15	heat shock protein 90 alpha family class A member 1	Homo sapiens	88-93
10412802-5	1999	In both patients, we found a Tau gene mutation in exon 10 at codon 279, resulting in an asparagine to lysine substitution (N279K).	Lysine	102-108	microtubule associated protein tau	Homo sapiens	29-32
19813219-1	2009	Lysyl oxidase (LOX) is a copper-dependent enzyme that initiates covalent crosslinking of elastin precursors by oxidizing peptidyl lysine to aminoadipic semi-aldehydes.	Lysine	130-136	lysyl oxidase	Rattus norvegicus	0-13
19813219-1	2009	Lysyl oxidase (LOX) is a copper-dependent enzyme that initiates covalent crosslinking of elastin precursors by oxidizing peptidyl lysine to aminoadipic semi-aldehydes.	Lysine	130-136	lysyl oxidase	Rattus norvegicus	15-18
19813219-1	2009	Lysyl oxidase (LOX) is a copper-dependent enzyme that initiates covalent crosslinking of elastin precursors by oxidizing peptidyl lysine to aminoadipic semi-aldehydes.	Lysine	130-136	elastin	Rattus norvegicus	89-96
10451115-8	1999	The present antibody was raised against an 18-residue peptide sequence (Lys 68-84 Val) derived from the human P2X1 sequence.	Lysine	72-75	purinergic receptor P2X 1	Homo sapiens	110-114
20046085-2	2009	This variant arises from a Lys --&gt; Asn substitution due to a mutation of AAA to AAC or AAT at codon 133 of the beta-globin gene.	Lysine	27-30	glycine-N-acyltransferase	Homo sapiens	83-86
10524771-7	1999	Studies of the temperature dependence of AMP sensitivity and the interaction with Cibacron Blue Sepharose of carbamoylated fructose 1,6-bisphosphatase derivatives indicate that the lysine residue involved in AMP sensitivity is located at the allosteric AMP site, while the lysine residue involved in AMP cooperativity is at a distinct location.	Lysine	181-187	fructose-bisphosphatase 1	Sus scrofa	123-150
19918057-8	2009	A detailed analysis of histone modifications in the neighborhood of H3T3 reveals that increasing methylation at Lys-4 (H3K4) strongly decreases substrate recognition, suggesting a key role of H3K4 methylation in the regulation of haspin activity.	Lysine	112-115	histone H3 associated protein kinase	Homo sapiens	230-236
10524771-7	1999	Studies of the temperature dependence of AMP sensitivity and the interaction with Cibacron Blue Sepharose of carbamoylated fructose 1,6-bisphosphatase derivatives indicate that the lysine residue involved in AMP sensitivity is located at the allosteric AMP site, while the lysine residue involved in AMP cooperativity is at a distinct location.	Lysine	273-279	fructose-bisphosphatase 1	Sus scrofa	123-150
19887642-0	2009	HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain.	Lysine	81-87	Vif	Human immunodeficiency virus 1	6-9
19887642-3	2009	Structure-guided mutagenesis of A3G focused on the 14 most surface-exposed Lys residues allowed us to identify four Lys residues (Lys-297, 301, 303, and 334) that are required for Vif-mediated A3G ubiquitination and degradation.	Lysine	75-78	Vif	Human immunodeficiency virus 1	180-183
10445847-1	1999	The downregulation of tyrosine kinase receptors attenuates signalling and is thought to be dependent upon intrinsic receptor kinase activity, largely because down-regulation is inhibited by a kinase-inactivating mutation of an invariant lysine residue of the receptors for EGF, insulin, M-CSF and PDGF.	Lysine	237-243	colony stimulating factor 1	Homo sapiens	287-292
19759018-8	2009	A point mutation of the highly conserved lysine residue in the helicase domain, although retaining the wild type level of annealing activity, inactivated ATPase and helicase activities and eliminated stable complex formation.	Lysine	41-47	Vacuolar H[+] ATPase 14kD subunit 1	Drosophila melanogaster	154-160
10387021-2	1999	Among various pancreatic PLA2s, bovine pancreatic PLA2 (bpPLA2) has a unique interfacial binding mode in which Lys-56 plays an important role in its binding to anionic lipid surfaces.	Lysine	111-114	LOC104974671	Bos taurus	25-29
19841277-3	2009	Here, we synthesized Abeta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures.	Lysine	103-106	amyloid beta precursor protein	Rattus norvegicus	21-26
19841277-3	2009	Here, we synthesized Abeta variants site-specifically modified with the cholesterol aldehyde at Asp-1, Lys-16, or Lys-28, rather than studying mixtures.	Lysine	114-117	amyloid beta precursor protein	Rattus norvegicus	21-26
19841277-5	2009	In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified Abeta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates.	Lysine	87-90	amyloid beta precursor protein	Rattus norvegicus	103-108
19841277-5	2009	In contrast, the modification site differentially influences the aggregation kinetics; Lys-16-modified Abeta formed amorphous aggregates fastest and at the lowest concentration (within 2 h at a concentration of 20 nM), followed by the Lys-28 and Asp-1 conjugates.	Lysine	235-238	amyloid beta precursor protein	Rattus norvegicus	103-108
19841277-6	2009	Also, the aggregates resulting from Abeta Lys-16 cholesterol aldehyde conjugation were more toxic to primary rat cortical neurons than treatment with unmodified Abeta under identical conditions and at the same concentration.	Lysine	42-45	amyloid beta precursor protein	Rattus norvegicus	36-41
19841277-7	2009	Our results show that Abeta modification by cholesterol derivatives, especially at Lys-16, renders it kinetically and thermodynamically competent to form neurotoxic aggregates at concentrations approaching the physiologic concentration of Abeta.	Lysine	83-86	amyloid beta precursor protein	Rattus norvegicus	22-27
10394366-7	1999	In contrast to RasGAP and RhoGAP, Arg-74 could be substituted by lysine and contributed significantly to the binding of Ran.	Lysine	65-71	RAN, member RAS oncogene family	Homo sapiens	120-123
10329707-5	1999	By examining a surface electrostatic potential distribution, multiple conserved lysines are revealed on one face of Atx1p.	Lysine	80-87	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	116-121
19463976-5	2009	Furthermore sulfo-NHS acetate (SNA) blocking of tropoelastin lysine side chains eliminated the SDS-resistant binding of tropoelastin to PIII-treated polystyrene.	Lysine	61-67	elastin	Homo sapiens	48-60
19463976-5	2009	Furthermore sulfo-NHS acetate (SNA) blocking of tropoelastin lysine side chains eliminated the SDS-resistant binding of tropoelastin to PIII-treated polystyrene.	Lysine	61-67	elastin	Homo sapiens	120-132
19463976-6	2009	This implies tropoelastin is covalently attached to the PIII-treated surface via its lysine side chains.	Lysine	85-91	elastin	Homo sapiens	13-25
10329707-8	1999	Copper trafficking to Ccc2p also relied on the lysine-rich face of Atx1p.	Lysine	47-53	copper metallochaperone ATX1	Saccharomyces cerevisiae S288C	67-72
19819978-5	2009	Substitution of these lysines by arginines in TRalpha decreased ligand binding affinity and precluded ligand-dependent release of corepressors and recruitment of coactivators.	Lysine	22-29	T cell receptor alpha locus	Homo sapiens	46-53
10320750-3	1999	The results of DNA sequencing, protein analysis, and cell cycle analysis demonstrate that the CHO-K1 and CHO-WBL cell lines have mutant p53 sequence [a mutation in codon 211 in exon 6 resulting in a change from Thr (ACA) to Lys (AAA)], mutant protein (high spontaneous levels that are non-inducible after X-irradiation), and mutant function (lack of G1 checkpoint).	Lysine	224-227	cellular tumor antigen p53	Cricetulus griseus	136-139
19783983-5	2009	Here, we show that direct interaction between the chromodomain of Tip60 and histone H3 trimethylated on lysine 9 (H3K9me3) at DSBs activates the acetyltransferase activity of Tip60.	Lysine	104-110	lysine acetyltransferase 5	Homo sapiens	66-71
10376244-7	1999	In some UHT and in-bottle sterilized dietetic milks their different composition resulted in an increase in the blocked lysine content.	Lysine	119-125	UHT	Bos taurus	8-11
19783983-5	2009	Here, we show that direct interaction between the chromodomain of Tip60 and histone H3 trimethylated on lysine 9 (H3K9me3) at DSBs activates the acetyltransferase activity of Tip60.	Lysine	104-110	lysine acetyltransferase 5	Homo sapiens	175-180
19829382-6	2009	In contrast, mice with point mutations in the conserved lysine residue of the potential ATP-binding site of the kinase domain, which mediates Ilk binding to alpha-parvin, die owing to renal agenesis.	Lysine	56-62	parvin, alpha	Mus musculus	157-169
10341419-6	1999	We hypothesized that the KEX1 homologue in P. pastoris is responsible for the loss of the C-terminal lysine of endostatin.	Lysine	101-107	collagen type XVIII alpha 1 chain	Homo sapiens	111-121
19828042-3	2009	Stress-induced homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates p53 at serine-46 (Ser46) for p53 apoptotic activity; p53 acetylation at different C-terminus lysines including p300-mediated lysine-382 (Lys382) is also required for full activation of p53 transcriptional activity.	Lysine	172-179	homeodomain interacting protein kinase 2	Homo sapiens	15-55
19828042-3	2009	Stress-induced homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates p53 at serine-46 (Ser46) for p53 apoptotic activity; p53 acetylation at different C-terminus lysines including p300-mediated lysine-382 (Lys382) is also required for full activation of p53 transcriptional activity.	Lysine	172-179	homeodomain interacting protein kinase 2	Homo sapiens	57-62
19828042-3	2009	Stress-induced homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates p53 at serine-46 (Ser46) for p53 apoptotic activity; p53 acetylation at different C-terminus lysines including p300-mediated lysine-382 (Lys382) is also required for full activation of p53 transcriptional activity.	Lysine	172-178	homeodomain interacting protein kinase 2	Homo sapiens	15-55
19828042-3	2009	Stress-induced homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates p53 at serine-46 (Ser46) for p53 apoptotic activity; p53 acetylation at different C-terminus lysines including p300-mediated lysine-382 (Lys382) is also required for full activation of p53 transcriptional activity.	Lysine	172-178	homeodomain interacting protein kinase 2	Homo sapiens	57-62
19825828-4	2009	Through the use of the Ubc13-Uev1A E2 complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling.	Lysine	65-71	ubiquitin-conjugating enzyme E2N	Mus musculus	23-28
10341419-9	1999	Disruption of the KEX1 reading frame allowed expression of murine and human endostatin with the C-terminal lysine.	Lysine	107-113	collagen type XVIII alpha 1 chain	Homo sapiens	76-86
10074180-12	1999	These results are consistent with the existence of an essential juxtamembrane salt bridge between lysine 499 on the PDGF beta receptor and an acidic residue in the C terminus of the E5 protein and lend support to our proposed model for the complex between the E5 dimer and the PDGF beta receptor.	Lysine	98-104	platelet derived growth factor, B polypeptide	Mus musculus	116-125
19567879-3	2009	We report that M2-macrophage marker genes are epigenetically regulated by reciprocal changes in histone H3 lysine-4 (H3K4) and histone H3 lysine-27 (H3K27) methylation; and the latter methylation marks are removed by the H3K27 demethylase Jumonji domain containing 3 (Jmjd3).	Lysine	107-113	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	239-266
10074180-12	1999	These results are consistent with the existence of an essential juxtamembrane salt bridge between lysine 499 on the PDGF beta receptor and an acidic residue in the C terminus of the E5 protein and lend support to our proposed model for the complex between the E5 dimer and the PDGF beta receptor.	Lysine	98-104	platelet derived growth factor, B polypeptide	Mus musculus	277-286
19567879-3	2009	We report that M2-macrophage marker genes are epigenetically regulated by reciprocal changes in histone H3 lysine-4 (H3K4) and histone H3 lysine-27 (H3K27) methylation; and the latter methylation marks are removed by the H3K27 demethylase Jumonji domain containing 3 (Jmjd3).	Lysine	107-113	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	268-273
10082574-7	1999	We also provide evidence showing that lysines located in helices 3 and 4, which define part of hRARalpha NCoA binding surface, contribute differently to (i) the transcriptional activity and (ii) the interaction of RXR-RAR heterodimers with SRC-1, when challenged by either natural or RAR-selective retinoids.	Lysine	38-45	retinoic acid receptor alpha	Homo sapiens	96-99
19809202-7	2009	We found that Gap1 was removed from the plasma membrane in the presence of ethanol in a Rsp5-dependent manner, and that the disappearance of Gap1 required Ubc4 and involved the lysine residues of ubiquitin.	Lysine	177-183	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	155-159
10082574-7	1999	We also provide evidence showing that lysines located in helices 3 and 4, which define part of hRARalpha NCoA binding surface, contribute differently to (i) the transcriptional activity and (ii) the interaction of RXR-RAR heterodimers with SRC-1, when challenged by either natural or RAR-selective retinoids.	Lysine	38-45	retinoic acid receptor alpha	Homo sapiens	218-221
10079079-6	1999	Thus, we isolated the DHS-22 binding factor from bovine brain nuclear extracts and finally identified it as NF90 on the basis of molecular mass analysis of Lys-C-digested fragments and amino acid sequences of the two peptides of the trypsin-digested binding protein.	Lysine	156-159	interleukin enhancer binding factor 3	Homo sapiens	108-112
19734210-3	2009	We have identified a putative transcription start site in the P2Y(2)R gene and demonstrated acetylation of Lys(14) on histone H3 and Lys(8) on histone H4, thus suggesting that the chromatin associated with the P2Y(2) promoter is accessible to transcription factors.	Lysine	107-110	purinergic receptor P2Y2	Homo sapiens	62-69
19734210-3	2009	We have identified a putative transcription start site in the P2Y(2)R gene and demonstrated acetylation of Lys(14) on histone H3 and Lys(8) on histone H4, thus suggesting that the chromatin associated with the P2Y(2) promoter is accessible to transcription factors.	Lysine	107-110	purinergic receptor P2Y2	Homo sapiens	62-68
19734210-3	2009	We have identified a putative transcription start site in the P2Y(2)R gene and demonstrated acetylation of Lys(14) on histone H3 and Lys(8) on histone H4, thus suggesting that the chromatin associated with the P2Y(2) promoter is accessible to transcription factors.	Lysine	133-136	purinergic receptor P2Y2	Homo sapiens	62-69
10022867-7	1999	Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9- or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.	Lysine	159-165	DNA-(apurinic or apyrimidinic site) lyase APN2	Saccharomyces cerevisiae S288C	15-19
19734210-3	2009	We have identified a putative transcription start site in the P2Y(2)R gene and demonstrated acetylation of Lys(14) on histone H3 and Lys(8) on histone H4, thus suggesting that the chromatin associated with the P2Y(2) promoter is accessible to transcription factors.	Lysine	133-136	purinergic receptor P2Y2	Homo sapiens	62-68
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	29-35	LOC100153898	Sus scrofa	165-170
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Lysine	29-35	LOC100153898	Sus scrofa	191-196
10022867-7	1999	Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9- or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.	Lysine	159-165	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	23-27
10191072-1	1999	The arrangement of mitochondrial tRNA genes for lysine (K) and aspartate (D) from the junction of the cytochrome oxidase II and ATPase 8 genes was determined in a range of hymenopteran taxa.	Lysine	48-54	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	33-37
19855050-0	2009	ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.	Lysine	62-68	trithorax	Drosophila melanogaster	12-21
9990037-3	1999	Three suppressors were isolated for one Hsp90 mutant (glutamate --&gt; lysine at amino acid 381).	Lysine	71-77	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	40-45
19774086-1	2009	BACKGROUND: Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in plants and mammals.	Lysine	139-145	aminoadipate-semialdehyde synthase	Homo sapiens	12-69
19774086-1	2009	BACKGROUND: Lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) is a bifunctional enzyme catalyzing the first two steps of lysine catabolism in plants and mammals.	Lysine	139-145	aminoadipate-semialdehyde synthase	Homo sapiens	71-78
19774086-2	2009	However, to date, the properties of the lysine degradation pathway and biological functions of LKR/SDH have been very little described in arthropods such as ticks.	Lysine	40-46	aminoadipate-semialdehyde synthase	Homo sapiens	95-102
9885291-5	1999	The precise molecular role for the SUMO-1 modification of PML is unclear, and the specific lysine residues within PML that are targeted for modification and the PML sub-domains necessary for mediating the modification in vivo are unknown.	Lysine	91-97	PML nuclear body scaffold	Homo sapiens	114-117
9885291-5	1999	The precise molecular role for the SUMO-1 modification of PML is unclear, and the specific lysine residues within PML that are targeted for modification and the PML sub-domains necessary for mediating the modification in vivo are unknown.	Lysine	91-97	PML nuclear body scaffold	Homo sapiens	114-117
9882738-5	1999	Mutation of acidic residues (D540, E544) in the S4-S5 linker of HERG channels to neutral (Ala) or basic (Lys) residues accelerated the rate of channel deactivation.	Lysine	105-108	potassium voltage-gated channel subfamily H member 2	Homo sapiens	64-68
19500832-2	2009	Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine.	Lysine	138-144	elastin	Homo sapiens	6-13
19500832-2	2009	Alpha-elastin was chemically crosslinked with hexamethylene diisocyanate that can react with various functional groups in elastin such as lysine, cysteine, and histidine.	Lysine	138-144	elastin	Homo sapiens	122-129
9862963-9	1999	These results demonstrate a critical role for lysine 392 in the activation and dimerization of RNase L, thus suggesting that these two activities are intimately linked.	Lysine	46-52	ribonuclease L	Homo sapiens	95-102
19596907-8	2009	The suppression of esa1"s growth defect by disruption of Rpd3L was dependent on lysine 12 of histone H4.	Lysine	80-86	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	19-23
19596907-9	2009	We propose a model whereby Esa1 and Rpd3L act coordinately to control the acetylation of H4 lysine 12 to regulate transcription, thereby emphasizing the importance of dynamic acetylation and deacetylation of this particular histone residue in maintaining cell viability.	Lysine	92-98	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	27-31
19574226-7	2009	Amino-terminal sequences of Arn1p were required for vacuolar protein sorting, as mutation of ubiquitinatable lysine residues resulted in accumulation on the vacuolar membrane, and mutation of either a THN or YGL sequence resulted in mis-sorting to the plasma membrane.	Lysine	109-115	siderophore transporter	Saccharomyces cerevisiae S288C	28-33
10327586-6	1999	Formaldehyde also reacts with the lysine residues of beta 2 GPI, but does not expose the epitope.	Lysine	34-40	apolipoprotein H	Homo sapiens	53-63
19394199-1	2009	BACKGROUND: Classical lysyl oxidase (LO) is involved in the stabilization and repair of extracellular matrix by the oxidization of lysine residues in collagen and elastin.	Lysine	131-137	elastin	Homo sapiens	163-170
10327586-8	1999	These data provide evidence that binding of lysine residues is not a sufficient condition for exposure of the autoepitope, and also support the likelihood that anti-beta 2 GPI antibodies bind only to aggregates of the protein.	Lysine	44-50	apolipoprotein H	Homo sapiens	165-175
10071930-4	1999	The results indicate the presence of both glutamine and lysine residues in RAP, accessible for transglutaminase cross-linking.	Lysine	56-62	LDL receptor related protein associated protein 1	Homo sapiens	75-78
19578370-2	2009	Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that the NAD(+)-dependent deacetylase SIRT1 (sirtuin-1) removes the acetyl group from K633.	Lysine	130-136	sirtuin 1	Homo sapiens	235-240
19578370-2	2009	Here we show that the acetyltransferase MOF (males absent on the first) acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that the NAD(+)-dependent deacetylase SIRT1 (sirtuin-1) removes the acetyl group from K633.	Lysine	130-136	sirtuin 1	Homo sapiens	242-251
10353619-2	1999	In order to obtain transdermally deliverable analogs of gonadotropin releasing hormone (GnRH), we have synthesized related hydrophobic derivatives by attaching various aliphatic acids to the N(epsilon)-amino side chain of [D-Lys]6GnRH, a superactive GnRH agonist.	Lysine	225-228	gonadotropin releasing hormone 1	Rattus norvegicus	56-86
19680533-7	2009	The direct targets of PKL in roots include the PcG genes SWINGER and EMBRYONIC FLOWER2 that encode subunits of Polycomb repressive complexes responsible for trimethylating histone H3 at lysine 27 (H3K27me3).	Lysine	186-192	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	22-25
19465479-6	2009	In vitro ubiquitination of Daxx by CHIP revealed that ubiquitin chain formation utilizes non-canonical lysine linkages associated with resistance to proteasomal degradation.	Lysine	103-109	Fas death domain-associated protein	Mus musculus	27-31
10353619-2	1999	In order to obtain transdermally deliverable analogs of gonadotropin releasing hormone (GnRH), we have synthesized related hydrophobic derivatives by attaching various aliphatic acids to the N(epsilon)-amino side chain of [D-Lys]6GnRH, a superactive GnRH agonist.	Lysine	225-228	gonadotropin releasing hormone 1	Rattus norvegicus	88-92
19465479-7	2009	The ubiquitination of Daxx by CHIP utilizes lysines 630 and 631 and competes with the sumoylation machinery of the cell at these residues.	Lysine	44-51	Fas death domain-associated protein	Mus musculus	22-26
19491097-4	2009	Here, we show that PGC-1beta is acetylated on at least 10 lysine residues distributed along the length of the protein by the acetyl transferase general control of amino-acid synthesis (GCN5) and that this acetylation reaction is reversed by the deacetylase sirtuin 1 (SIRT1).	Lysine	58-64	lysine acetyltransferase 2A	Homo sapiens	185-189
9836618-0	1998	Constrained corticotropin-releasing factor (CRF) agonists and antagonists with i-(i+3) Glu-Xaa-DXbb-Lys bridges.	Lysine	100-103	corticotropin releasing hormone	Homo sapiens	12-42
19602237-4	2009	RIZ1 is a PR domain methyltransferase that methylates histone H3 lysine 9, a modification important for transcriptional repression.	Lysine	65-71	PR/SET domain 2	Homo sapiens	0-4
9792664-1	1998	Aspartate aminotransferase (AspAT) is a unique enzyme that can react with two types of substrate with quite different properties, acidic substrates, such as aspartate and glutamate, and neutral substrates, although the catalytic group Lys-258 acts on both types of substrate.	Lysine	235-238	aspartate/prephenate aminotransferase	Thermus thermophilus HB8	0-26
19432880-4	2009	In addition, the Mdmx mutant cooperates with Mdm2 to induce ubiquitination of p53 at C-terminal lysine residues, and the integrity of the C-terminal lysines was partly required for the cooperative inhibition.	Lysine	96-102	MDM2 proto-oncogene	Homo sapiens	45-49
9792674-0	1998	Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding.	Lysine	0-6	C-C motif chemokine ligand 2	Homo sapiens	60-94
19462465-9	2009	CYLD DUB activity is highly specific for lysine 63 (K63)-linked Ub chains but has been shown to act on K48-linked Ub chains as well.	Lysine	41-47	CYLD lysine 63 deubiquitinase	Homo sapiens	0-4
19542455-5	2009	Ubiquitin modification of lysine residues K168 and K183, but not K192, in the cytoplasmic domain of CD83 was shown to be necessary for GRAIL-mediated degradation of CD83.	Lysine	26-32	ring finger protein 128	Homo sapiens	135-140
9792674-4	1998	We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C.	Lysine	15-21	C-C motif chemokine ligand 2	Homo sapiens	69-74
9792674-9	1998	Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans.	Lysine	32-35	C-C motif chemokine ligand 2	Homo sapiens	92-97
9917090-2	1998	Here, we describe an improved immunogene system, in which the antigen-binding (Fab) fragments of the monoclonal antibody (Ab) B4G7 against the human EGFR were conjugated with poly-L-lysine to form a gene delivery vehicle (designated Fab "immunoporter").	Lysine	175-188	FA complementation group B	Homo sapiens	79-82
19517532-1	2009	We describe a method for studying quantitative changes in accessibility of surface lysine residues of the PB1 subunit of the influenza RNA polymerase as a result of association with the PA subunit to form a PB1-PA heterodimer.	Lysine	83-89	polybromo 1	Homo sapiens	106-109
9917090-2	1998	Here, we describe an improved immunogene system, in which the antigen-binding (Fab) fragments of the monoclonal antibody (Ab) B4G7 against the human EGFR were conjugated with poly-L-lysine to form a gene delivery vehicle (designated Fab "immunoporter").	Lysine	175-188	FA complementation group B	Homo sapiens	233-236
19517532-1	2009	We describe a method for studying quantitative changes in accessibility of surface lysine residues of the PB1 subunit of the influenza RNA polymerase as a result of association with the PA subunit to form a PB1-PA heterodimer.	Lysine	83-89	polybromo 1	Homo sapiens	207-210
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Lysine	25-32	apolipoprotein H	Homo sapiens	57-65
19523850-2	2009	We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3) and gene expression profiles in naive and memory CD8(+) T cells.	Lysine	79-85	CD8a molecule	Homo sapiens	167-170
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Lysine	25-32	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Lysine	25-32	apolipoprotein H	Homo sapiens	121-129
19432794-3	2009	The bioactivity of each peptide variant was evaluated by colony overlay assay, and hence we identified three Lys residues (Lys1, Lys2 and Lys3) that provided electrostatic interactions with the target membrane and were significantly variable.	Lysine	109-112	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	129-133
9763552-2	1998	Threonine 85 underlies the opening of the main beta-sheet of the molecule and its replacement, by the polar lysine, in antithrombin Wobble, resulted in a plasma deficiency of antithrombin with an uncharacteristically severe onset of thrombosis at 10 years of age, whereas the replacement of the same residue by a nonpolar methionine, antithrombin Wibble, gave near-normal levels of plasma antithrombin and more typical adult thromboembolic disease.	Lysine	108-114	serpin family C member 1	Homo sapiens	119-131
19359167-2	2009	NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.	Lysine	37-43	lysine demethylase 4A	Homo sapiens	57-73
9763552-2	1998	Threonine 85 underlies the opening of the main beta-sheet of the molecule and its replacement, by the polar lysine, in antithrombin Wobble, resulted in a plasma deficiency of antithrombin with an uncharacteristically severe onset of thrombosis at 10 years of age, whereas the replacement of the same residue by a nonpolar methionine, antithrombin Wibble, gave near-normal levels of plasma antithrombin and more typical adult thromboembolic disease.	Lysine	108-114	serpin family C member 1	Homo sapiens	175-187
9763552-2	1998	Threonine 85 underlies the opening of the main beta-sheet of the molecule and its replacement, by the polar lysine, in antithrombin Wobble, resulted in a plasma deficiency of antithrombin with an uncharacteristically severe onset of thrombosis at 10 years of age, whereas the replacement of the same residue by a nonpolar methionine, antithrombin Wibble, gave near-normal levels of plasma antithrombin and more typical adult thromboembolic disease.	Lysine	108-114	serpin family C member 1	Homo sapiens	175-187
9763552-2	1998	Threonine 85 underlies the opening of the main beta-sheet of the molecule and its replacement, by the polar lysine, in antithrombin Wobble, resulted in a plasma deficiency of antithrombin with an uncharacteristically severe onset of thrombosis at 10 years of age, whereas the replacement of the same residue by a nonpolar methionine, antithrombin Wibble, gave near-normal levels of plasma antithrombin and more typical adult thromboembolic disease.	Lysine	108-114	serpin family C member 1	Homo sapiens	175-187
9774110-8	1998	Moreover, our data show that dCBP acetylates a conserved lysine in the Armadillo-binding domain of dTCF, and that this acetylation lowers the affinity of Armadillo binding to dTCF.	Lysine	57-63	sarcoplasmic calcium-binding protein	Drosophila melanogaster	29-33
19451217-3	2009	Here, we show that expression of the histone H3 Lys 27 (H3K27) demethylase JMJD3 is induced upon activation of the RAS-RAF signaling pathway.	Lysine	48-51	lysine demethylase 6B	Homo sapiens	75-80
19454348-1	2009	The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity.	Lysine	37-43	DExD/H-box helicase 58	Homo sapiens	124-129
9727001-5	1998	When the lysine residue in guinea pig Kir1.3 (gpKir1.3) isolated from a genomic library was changed to an asparagine (reverse HPS mutation), mutant channels yielded macroscopic currents with amplitudes increased 6-fold.	Lysine	9-15	inwardly rectifying potassium channel Kir1.3	Cavia porcellus	38-44
19306858-6	2009	Lys(57) is conserved among species and mutation of this residue is predicted to affect HGD protein function by interfering with substrate traffic at the active site.	Lysine	0-3	homogentisate 1,2-dioxygenase	Homo sapiens	87-90
9724691-5	1998	The rps5-1 mutation causes a glutamate-to-lysine substitution in the third LRR and partially compromises the function of several R genes that confer bacterial and downy mildew resistance.	Lysine	42-48	Disease resistance protein (CC-NBS-LRR class) family	Arabidopsis thaliana	4-8
18946634-6	2009	Allelic frequencies in wild type of XRCC1 C26304T were 91.1% C(Arg); G27466A 62.9% G(Arg); G23591A 60.3% G(Arg); APE1 T2197G 75.1% T(Asp) and XPD A35931C 71.8% A(Lys).	Lysine	162-165	X-ray repair cross complementing 1	Homo sapiens	36-41
19283672-1	2009	Lysyl oxidase (LOX) catalyzes the oxidation of the side chain of a peptidyl lysine converting specific lysine and hydroxylysine residues of alpha-aminoadipic-delta-semialdehydes, which form covalent crosslinks in collagens and elastin.	Lysine	76-82	lysyl oxidase	Homo sapiens	15-18
9727486-4	1998	A model for histone H4 binding by Hat1 is discussed in terms of possible sources of specific lysine recognition by the enzyme.	Lysine	93-99	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	34-38
9694813-14	1998	Residues Gln-210 and Lys-221 are located within a region of CRALBP exhibiting sequence homology with the ligand binding cavity of yeast phosphatidylinositol-transfer protein.	Lysine	21-24	retinaldehyde binding protein 1	Homo sapiens	60-66
9694813-15	1998	The data implicate Gln-210 and Lys-221 as components of the CRALBP retinoid binding cavity and are discussed in the context of ligand interactions in structurally or functionally related proteins with known crystallographic structures.	Lysine	31-34	retinaldehyde binding protein 1	Homo sapiens	60-66
19224989-2	2009	We have shown previously that SSP is a key element in GPC-mediated membrane fusion, and that GPC sensitivity to acidic pH is modulated in part through the lysine residue at position 33 in the ectodomain loop of SSP (J. York and J. H. Nunberg, J. Virol.	Lysine	155-161	glycophorin C (Gerbich blood group)	Homo sapiens	93-96
9692954-11	1998	Homology modeling of PEDF based on the X-ray crystal structures of antithrombin III and ovalbumin shows a region at the center of beta-sheet A-strands 2 and 3- and helix F that has a basic electrostatic surface potential and is densely populated with lysines exposed to the surface (K134, K137, K189, K191, H212, and K214) that are available to interact with various glycosaminoglycans/polyanions.	Lysine	251-258	serpin family C member 1	Homo sapiens	67-83
9657985-8	1998	In conclusion, LDL may be a physiological regulator of haemostatic mechanisms through the interactions of lysine-rich domains of apo B-100 with tissue factor.	Lysine	106-112	coagulation factor III, tissue factor	Homo sapiens	144-157
19304754-4	2009	MAML1 interacts with the C/H3 domain of p300, and the p300-MAML1 complex specifically acetylates lysines of histone H3 and H4 tails in chromatin in vitro.	Lysine	97-104	mastermind like transcriptional coactivator 1	Homo sapiens	0-5
19304754-4	2009	MAML1 interacts with the C/H3 domain of p300, and the p300-MAML1 complex specifically acetylates lysines of histone H3 and H4 tails in chromatin in vitro.	Lysine	97-104	mastermind like transcriptional coactivator 1	Homo sapiens	59-64
19208623-6	2009	In response to DNA damage, Lys-164 of PCNA undergoes ubiquitination by the RAD6-RAD18 complex, and the ubiquitination is considered to facilitate TLS.	Lysine	27-30	RAD18 E3 ubiquitin protein ligase	Homo sapiens	80-85
9651165-0	1998	Minimal-size, constrained corticotropin-releasing factor agonists with i-(i+3) Glu-Lys and Lys-Glu bridges.	Lysine	83-86	corticotropin releasing hormone	Homo sapiens	26-56
19395867-2	2009	Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	125-131	lysine demethylase 1A	Homo sapiens	0-29
19395867-2	2009	Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	125-131	lysine demethylase 1A	Homo sapiens	31-35
19395867-2	2009	Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	145-151	lysine demethylase 1A	Homo sapiens	0-29
19395867-2	2009	Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	145-151	lysine demethylase 1A	Homo sapiens	31-35
9651165-0	1998	Minimal-size, constrained corticotropin-releasing factor agonists with i-(i+3) Glu-Lys and Lys-Glu bridges.	Lysine	91-94	corticotropin releasing hormone	Homo sapiens	26-56
9665406-4	1998	Here we report a novel mutation in a French monilethrix family, which again consists of a lysine substitution of another highly conserved glutamic acid residue, Glu402 (Glu106 of the 2B subdomain), in the EIATYRRLLEGEE motif of hHb1.	Lysine	90-96	keratin 86	Homo sapiens	228-232
19223320-8	2009	In addition, we report the identification of a K (lysine)-rich domain in all SBP2s, essential for SECIS and 60S ribosomal subunit binding, differing from the well-characterized L7Ae RNA-binding domain.	Lysine	50-56	SECIS binding protein 2	Homo sapiens	77-81
19228710-3	2009	RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1-dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.	Lysine	163-169	RAD18 E3 ubiquitin protein ligase	Homo sapiens	0-5
19228710-3	2009	RAD18 associates with 53BP1 and is recruited to DSB sites in a 53BP1-dependent manner specifically during G1-phase, RAD18 monoubiquitinates KBD domain of 53BP1 at lysine 1268 in vitro.	Lysine	163-169	RAD18 E3 ubiquitin protein ligase	Homo sapiens	116-121
19282482-0	2009	Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.	Lysine	52-58	DNA methyltransferase 1	Homo sapiens	14-19
9622551-3	1998	Taking into account the substrate specificity of DPP IV for P2-P1&gt;&lt;-P1" cleavage, we have designed and synthesized cyclopeptides c[(alphaH2N+)-Lys-Pro-Aba-(6-CH2-S+R2)-Glyn] 2TFA- (Aba = 3-aminobenzoic acid, R = alkyl) possessing a proline at the P1 position and a lysine in the P2 position, which allows the closing of the cycle on its side chain.	Lysine	271-277	dipeptidyl peptidase 4	Homo sapiens	49-55
19131338-6	2009	Although the NIF-1 complex contains Ash2L, RbBP5, and WDR5, suggesting that the complex might methylate histone H3-Lys-4, we found that the complex contains a H3 methyltransferase activity that modifies a residue other than H3-Lys-4.	Lysine	115-118	zinc finger protein 335	Homo sapiens	13-18
19208803-4	2009	In this CML model, AS targets BCR/ABL through the ubiquitination of key lysine residues, leading to its proteasomal degradation, whereas IM inhibits the PI3K/AKT/mTOR pathway.	Lysine	72-78	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	30-37
9660190-8	1998	The nikC-inactivated mutant grew with L-lysine as sole source of nitrogen and carbon, indicating that L-lysine 2-aminotransferase is not required for lysine catabolism.	Lysine	38-46	relaxosome accessory protein	Escherichia coli	4-8
19073596-0	2009	MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines.	Lysine	130-137	F-box protein 32	Homo sapiens	0-5
19073596-0	2009	MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines.	Lysine	130-137	F-box protein 32	Homo sapiens	6-15
19203579-5	2009	We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1.	Lysine	166-172	BRCA1 DNA repair associated	Homo sapiens	257-262
9660190-8	1998	The nikC-inactivated mutant grew with L-lysine as sole source of nitrogen and carbon, indicating that L-lysine 2-aminotransferase is not required for lysine catabolism.	Lysine	40-46	relaxosome accessory protein	Escherichia coli	4-8
9717296-4	1998	Plasmin binding was prevented, in a concentration-dependent manner, by the amino acids lysine, arginine and epsilon-aminocaproic acid.	Lysine	87-93	plasminogen	Bos taurus	0-7
19087956-8	2009	Finally, we show that the acetylated and methylated lysine mutants have strikingly different effects on the binding of Sir4 to yeast telomeres, suggesting that histone H3 acetylated lysine residues regulate yeast silencing through a mechanism independent of SIR binding.	Lysine	52-58	chromatin-silencing protein SIR4	Saccharomyces cerevisiae S288C	119-123
19087956-8	2009	Finally, we show that the acetylated and methylated lysine mutants have strikingly different effects on the binding of Sir4 to yeast telomeres, suggesting that histone H3 acetylated lysine residues regulate yeast silencing through a mechanism independent of SIR binding.	Lysine	182-188	chromatin-silencing protein SIR4	Saccharomyces cerevisiae S288C	119-123
19029251-8	2009	UBN1 binds to proliferation-promoting genes that are repressed by SAHF and associates with histone methyltransferase activity that methylates lysine 9 of histone H3, a site that is methylated in SAHF.	Lysine	142-148	ubinuclein 1	Homo sapiens	0-4
9592082-3	1998	Most phosphorylation occurs in the lys-ser-pro (KSP) repeats in the C-terminal tail domains of NF-H and NF-M.	Lysine	35-38	neurofilament medium chain	Rattus norvegicus	104-108
9633984-7	1998	GA 1 is an inborn error of lysine and tryptophan catabolism, caused by deficiency of the enzyme, glutaryl coenzyme-A dehydrogenase.	Lysine	27-33	glutaryl-CoA dehydrogenase	Homo sapiens	97-130
19115870-7	2009	mTG covalently links proteins through their glutamine (Gln) and lysine (Lys) residues.	Lysine	64-70	protease, serine 3	Mus musculus	0-3
19115870-7	2009	mTG covalently links proteins through their glutamine (Gln) and lysine (Lys) residues.	Lysine	72-75	protease, serine 3	Mus musculus	0-3
9600243-0	1998	The human glutaryl-CoA dehydrogenase gene: report of intronic sequences and of 13 novel mutations causing glutaric aciduria type I. Glutaric acidemia type I (GAI) (McKusick 231670) is an autosomal recessive disease affecting the catabolism of the amino acids lysine, hydroxylysine and tryptophan, caused by a defect in the gene encoding glutaryl-coenzyme A dehydrogenase (GCDH) and associated with severe neurological symptoms.	Lysine	259-265	glutaryl-CoA dehydrogenase	Homo sapiens	10-36
20104979-3	2009	METHODS: From March 1, 2005 to December 31, 2008, the polymerase chain reaction-restriction fragment length polymorphism method was applied to evaluate genetic polymorphisms of the XRCC1 codon399 (Arg/Gln) and XPD codon751 (Lys/Gln) DNA repair genes in 108 patients with stage IIIB and IV NSCLCs treated with platinum-based chemotherapy in the Department of Chemotherapy of Jiangsu Cancer Hospital and Research Institute.	Lysine	224-227	X-ray repair cross complementing 1	Homo sapiens	181-186
9516482-2	1998	Ras and Rap1A have Glu and Lys, respectively, at position 31.	Lysine	27-30	RAP1A, member of RAS oncogene family	Homo sapiens	8-13
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	interleukin 1 alpha	Homo sapiens	33-37
19001096-0	2009	Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation.	Lysine	19-25	histone H4	Drosophila melanogaster	32-42
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	interleukin 1 alpha	Homo sapiens	169-173
9497351-5	1998	Affinity labeling using sialyl-Lewisx in which the sialic acid has been mildly oxidized has been used to verify this switch in specificity and to show that the sialic acid-containing portion of the ligand interacts near the sequence Lys-Lys-Lys corresponding to residues 111-113 of E-selectin.	Lysine	233-236	selectin E	Homo sapiens	282-292
18952408-0	2009	Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet.	Lysine	40-46	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	52-57
18952408-4	2009	CONCLUSION: These observations indicate that induction of SGLT1 gene expression by feeding a high carbohydrate/fat ratio diet is associated with acetylation of histone H3 at lysine 9 on the SGLT1 gene.	Lysine	174-180	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	58-63
18952408-4	2009	CONCLUSION: These observations indicate that induction of SGLT1 gene expression by feeding a high carbohydrate/fat ratio diet is associated with acetylation of histone H3 at lysine 9 on the SGLT1 gene.	Lysine	174-180	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	190-195
9570506-3	1998	This sequence is derived from the laminin alpha1 chain, and its potency is increased by the formation of a 16mer polymerization using a lysine tree structure.	Lysine	136-142	laminin subunit alpha 1	Homo sapiens	34-48
18784356-2	2008	Using a series of nested deletion mutants, it is now shown that the two C-terminal lysine residues are required for the enhanced metastasis, invasion and migration abilities that S100A4 confers on cells in a model system of metastasis.	Lysine	83-89	S100 calcium binding protein A4	Homo sapiens	179-185
18784356-4	2008	In wild-type S100A4 protein, the presence of the C-terminal lysine, residue 101, enhances the rate of association between S100A4 and NMMHC-IIA.	Lysine	60-66	S100 calcium binding protein A4	Homo sapiens	13-19
18784356-4	2008	In wild-type S100A4 protein, the presence of the C-terminal lysine, residue 101, enhances the rate of association between S100A4 and NMMHC-IIA.	Lysine	60-66	S100 calcium binding protein A4	Homo sapiens	122-128
9646184-7	1998	It was highest in physiological conditions (PBS) where haemoglobin acted as a reversible non competitive inhibitor of BSAO activity, with apparent Ki of 0.5 mM at 37 degrees C. The inhibition was unaffected by partial BSAO deglycosylation (40% of glucidic residues removed) but decreased when haemoglobin lysine groups were derivatised using citraconic anhydride.	Lysine	305-311	primary amine oxidase, liver isozyme	Bos taurus	118-122
18809572-1	2008	Rsc4p, a subunit of the RSC chromatin-remodeling complex, is acetylated at lysine 25 by Gcn5p, a well-characterized histone acetyltransferase (HAT).	Lysine	75-81	lysine acetyltransferase 2A	Homo sapiens	88-93
9637370-6	1998	Its N-terminal sequence: SLFELGKMILQETGKNPAKSYGVYGCNCGVGGRGKPKDATDRCCYVHKCCYK... revealed high homology with other Lys 49 PLA2-like myotoxins from other bothropic venoms.	Lysine	115-118	phospholipase A2 group IB	Rattus norvegicus	122-126
18694457-4	2008	Histone H3 lysine-27 di- and tri-methylation are paternally enriched at the imprinted loci Mez1, ZmFie1 and Nrp1.	Lysine	11-17	histone-lysine N-methyltransferase EZ1	Zea mays	91-95
19036170-7	2008	Mass spectra of CA II treated with acetaldehyde revealed a modified protein form (+26 Da), consistent with a "Schiff base" formation between acetaldehyde and one of the primary NH2 groups (e.g., in lysine side chain) in the protein structure.	Lysine	198-204	carbonic anhydrase 2	Homo sapiens	16-21
9442102-5	1998	In contrast to most ubiquitinated proteins, only a single lysine residue (K526) in RanGAP1 can serve as the acceptor site for modification by SUMO-1.	Lysine	58-64	Ran GTPase activating protein 1	Homo sapiens	83-90
19026784-6	2008	Disruption of drICE ubiquitylation, either by mutation of DIAP1"s E3 activity or drICE"s ubiquitin-acceptor lysines, abrogates DIAP1"s ability to neutralize drICE and suppress apoptosis in vivo.	Lysine	108-115	Ribosomal protein S27A	Drosophila melanogaster	89-98
9490854-4	1998	In the absence of K+o, current through Kv1.4 was almost completely abolished due to the presence of a charged lysine residue at position 533 at the entrance to the pore.	Lysine	110-116	potassium voltage-gated channel subfamily A member 4	Homo sapiens	39-44
19026784-6	2008	Disruption of drICE ubiquitylation, either by mutation of DIAP1"s E3 activity or drICE"s ubiquitin-acceptor lysines, abrogates DIAP1"s ability to neutralize drICE and suppress apoptosis in vivo.	Lysine	108-115	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	127-132
19001125-0	2008	Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning.	Lysine	11-17	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	36-42
19001125-5	2008	Asf1 stimulates acetylation of histone H3 lysine 56 (H3K56) by the histone acetyltransferase Rtt109.	Lysine	42-48	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	0-4
19001125-5	2008	Asf1 stimulates acetylation of histone H3 lysine 56 (H3K56) by the histone acetyltransferase Rtt109.	Lysine	42-48	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	93-99
19001268-1	2008	Treatment of yeast and human cells with DNA-damaging agents elicits Rad6-Rad18-mediated monoubiquitination of proliferating cell nuclear antigen (PCNA) at its Lys-164 residue [ubiquitin (Ub)-PCNA], and this PCNA modification is indispensable for promoting the access of translesion synthesis (TLS) polymerases (Pols) to PCNA.	Lysine	159-162	RAD18 E3 ubiquitin protein ligase	Homo sapiens	73-78
18767117-0	2008	Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells.	Lysine	36-39	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	57-61
9417050-9	1998	Further, we have used thermodynamic mutant cycle analysis to demonstrate a specific interaction between this anionic amino acid and Lys-37 of ApB (DeltaDeltaG = 1.5 kcal/mol), a residue that is conserved among many sea anemone toxins.	Lysine	132-135	arginyl aminopeptidase	Rattus norvegicus	142-145
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32--&gt;Glu and Arg-42--&gt; Gly substitutions.	Lysine	111-114	glutathione S-transferase zeta 1	Homo sapiens	48-53
18852303-11	2008	Replacement of gamma-ENaC R138 with a conserved basic residue, lysine, preserved both the CAP2-induced I(Na) and the 75-kD gamma-ENaC fragment.	Lysine	63-69	sodium channel epithelial 1 subunit gamma	Homo sapiens	15-25
18852303-11	2008	Replacement of gamma-ENaC R138 with a conserved basic residue, lysine, preserved both the CAP2-induced I(Na) and the 75-kD gamma-ENaC fragment.	Lysine	63-69	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	90-94
18852303-11	2008	Replacement of gamma-ENaC R138 with a conserved basic residue, lysine, preserved both the CAP2-induced I(Na) and the 75-kD gamma-ENaC fragment.	Lysine	63-69	sodium channel epithelial 1 subunit gamma	Homo sapiens	123-133
9498640-17	1998	The actual profile is defined by deviations from this (above) and was -17 +/- 11, 7 +/- 10, -9 +/- 6 and -18 +/- 18% for [Nepsilon-palmitoyl Lys (B29)] human insulin and 17 +/- 12, 5 +/- 6, -9 +/- 15, 22 +/- 18% for NPH insulin at 3, 6, 9 and 12 h after s.c. injection.	Lysine	141-144	CD79b molecule	Homo sapiens	146-149
18925773-6	2008	Indeed, the MALDI-MS/MS identification of the CARM1 proteolytic cleavage site, which happens in a Lys/Arg/His free domain, could only be achieved using the DHB matrix.	Lysine	98-101	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
9405297-1	1998	Aminopeptidase B (Ap-B) is a Zn2+-dependent exopeptidase which selectively removes Arg and/or Lys residues from the N terminus of several peptide substrates.	Lysine	94-97	arginyl aminopeptidase	Rattus norvegicus	0-16
18849979-2	2008	Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69 of Swd2, the essential component of SET1/COMPASS in Saccharomyces cerevisiae.	Lysine	80-83	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	101-105
18849979-2	2008	Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69 of Swd2, the essential component of SET1/COMPASS in Saccharomyces cerevisiae.	Lysine	91-94	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	101-105
9405297-1	1998	Aminopeptidase B (Ap-B) is a Zn2+-dependent exopeptidase which selectively removes Arg and/or Lys residues from the N terminus of several peptide substrates.	Lysine	94-97	arginyl aminopeptidase	Rattus norvegicus	18-22
9388263-3	1997	To determine if the equivalent residue in the related thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a similar role, we have expressed and characterized four alpha2M variants in which this asparagine has been replaced by aspartate, alanine, histidine, or lysine.	Lysine	300-306	alpha-2-macroglobulin	Homo sapiens	113-120
9418242-3	1997	Sequence analysis of the clones which could rescue the Lys- mutant indicated the lysR gene.	Lysine	55-58	transcriptional regulator, LysR family	Escherichia coli	81-85
9418242-5	1997	In the Lys- mutant, the lysR gene was disrupted and the C-terminus region of the RimK protein was different from that of the wild-type, which contributed to the Lys- and kanamycin-resistant phenotype.	Lysine	7-10	transcriptional regulator, LysR family	Escherichia coli	24-28
9402962-5	1997	In the second family, we identified in affected individuals a lysine substitution of the corresponding glutamic acid residue, Glu 403, in the type II hair keratin hHb1, suggesting that this site represents a mutational hotspot in these highly related type II hair keratins.	Lysine	62-68	keratin 86	Homo sapiens	163-167
18764811-2	2008	The novel allele differs from B*44020101 by a single nucleotide change in exon 3 at nucleotide 453 (C--&gt;G), which changes codon 127 from asparagine (AAC) to lysine (AAG) explaining some aberrant B44 serology results in 2003.	Lysine	160-166	N-methylpurine DNA glycosylase	Homo sapiens	168-171
9365281-2	1997	Plasma membranes from cultured cells surface-labelled with 125I-alpha2-macroglobulin (a ligand that preferentially associates with clathrin-coated pits) were isolated by sonication of cells attached to a poly-L-lysine-coated substratum and incubated in the presence of nucleotide(s) +/- cytosol.	Lysine	204-217	alpha-2-macroglobulin	Homo sapiens	64-84
18765661-4	2008	Whereas mutation of two critical lysine residues within the second Ras-association domain of PLC-epsilon prevented K-Ras-dependent activation of the purified enzyme, guanine nucleotide-dependent activation by RhoA was retained.	Lysine	33-39	KRAS proto-oncogene, GTPase	Homo sapiens	115-120
18926491-7	2008	It is substantiated by the data on the Opaque-2 gene encoding a transcription factor with pleiotropic effect affecting lysine content and carbohydrate metabolism, thus acting indirectly on starch/amino acid ratio.	Lysine	119-125	regulatory protein opaque-2	Zea mays	39-47
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Lysine	40-46	MLO-like protein 4	Zea mays	73-104
18947029-10	2008	Complement C3 was significantly higher in men receiving lysine than in controls (p &lt; .05).	Lysine	56-62	complement C3	Homo sapiens	0-13
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Lysine	40-46	MLO-like protein 4	Zea mays	106-110
9376120-5	1997	However, ERK activation was maximal 2-4 h after plating, and adherence to either polystyrene or poly-L-lysine also caused ERK activation (fold increase 4 h after plating: fibronectin, 3.75 +/- 0.33; polystyrene, 3.95 +/- 0.78; poly-L-lysine, 2.14 +/- 0.36).	Lysine	96-109	fibronectin 1	Bos taurus	171-182
18564219-3	2008	It is well established that in the presence of thrombin-activated factor XIII (FXIIIa), alpha2AP becomes covalently ligated to the distal alpha chains of fibrin or fibrinogen at lysine 303 (two potential sites per molecule).	Lysine	178-184	serpin family F member 2	Homo sapiens	88-96
19172749-1	2008	Rtt109 is a histone acetyltransferase that requires a histone chaperone for the acetylation of histone 3 at lysine 56 (H3K56).	Lysine	108-114	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	0-6
18539592-0	2008	The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27.	Lysine	64-70	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	19-25
18539592-7	2008	Comparison of genomic datasets revealed that PKL-dependent genes are enriched for trimethylation of histone H3 lysine 27 (H3K27me3), a repressive epigenetic mark.	Lysine	111-117	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	45-48
9241232-0	1997	The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8-oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity.	Lysine	104-110	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	4-8
9236912-4	1997	Addition of a specific carboxypeptidase B inhibitor (Plummers inhibitor) could partly prevent the deletion of Lys-58 from cleaved beta 2-microglobulin, whereby Lys58-cleaved beta 2-microglobulin was obtained.	Lysine	110-113	beta-2-microglobulin	Homo sapiens	130-150
9146608-8	1997	BPH PSA had multiple internal cleavages in addition to the common cleavage site between lysines 145 and 146 of seminal fluid PSA.	Lysine	88-95	kallikrein related peptidase 3	Homo sapiens	4-7
18507738-4	2008	p39 and p35 contain localization motifs, such as a second Gly for myristoylation and Lys clusters in the N-terminal p10 region.	Lysine	85-88	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	8-11
18614053-3	2008	Here we report that yeast Eco1 and its human ortholog, ESCO1, both acetylate Smc3, a component of the cohesin complex that physically holds the sister chromatid together, at two conserved lysine residues.	Lysine	188-194	Eco1p	Saccharomyces cerevisiae S288C	26-30
9163585-3	1997	We now present investigations from two HbC compound heterozygotes which exhibit opposing effects upon HbC crystallization: HbC/Hb N-Baltimore (beta95 Lys--&gt;Glu) and HbC/Hb Riyadh (beta120 Lys--&gt;Asn).	Lysine	191-194	keratin 88, pseudogene	Homo sapiens	39-42
18297378-8	2008	The genotype 2DS1+/HLA-C lys(80)+ was more common in subjects with AS.	Lysine	25-28	major histocompatibility complex, class I, C	Homo sapiens	19-24
9065421-0	1997	Lysine residue 114 in human antithrombin III is required for heparin pentasaccharide-mediated activation.	Lysine	0-6	serpin family C member 1	Homo sapiens	28-44
18523274-2	2008	Accessible chromatin associated histone 3 lysine 9 acetylation (H3K9Ac) was found significantly higher at the proximal promoter and the first exon region of all three genes in memory CD8 T cells than in naive CD8 T cells.	Lysine	42-48	CD8a molecule	Homo sapiens	183-186
18523274-2	2008	Accessible chromatin associated histone 3 lysine 9 acetylation (H3K9Ac) was found significantly higher at the proximal promoter and the first exon region of all three genes in memory CD8 T cells than in naive CD8 T cells.	Lysine	42-48	CD8a molecule	Homo sapiens	209-212
9065421-5	1997	In contrast, lysine 114 was found to be critical in the activation of ATIII toward factor Xa.	Lysine	13-19	serpin family C member 1	Homo sapiens	70-75
18483406-4	2008	Epigenetically, ESC extracts induced CpG demethylation of Oct4 promoter, hyperacetylation of histones 3 and 4, and decreased lysine 9 (K-9) dimethylation of histone 3.	Lysine	125-131	keratin 9	Mus musculus	135-138
9065421-7	1997	These data are the first to demonstrate a pivotal role for lysine 114 in the pentasaccharide-mediated activation of ATIII.	Lysine	59-65	serpin family C member 1	Homo sapiens	116-121
9108279-12	1997	When compared to those of a wild-type strain, the frequencies of mutation to canavanine resistance (CanR) and reversion to Lys+ are sevenfold and tenfold higher for the ogg1 mutant strain, respectively.	Lysine	123-126	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	169-173
18524920-1	2008	In the yeast Saccharomyces cerevisiae, the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21.	Lysine	71-77	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	152-157
18524920-4	2008	Furthermore, results presented in this paper indicate that, in contrast to that which had been found for Lys20p, lysine is a strong allosteric inhibitor of Lys21p (K(i) 0.053 mM), which, in addition, induces positive co-operativity for alpha-ketoglutarate (alpha-KG) binding.	Lysine	113-119	homocitrate synthase LYS21	Saccharomyces cerevisiae S288C	156-162
9106516-0	1997	Soybean DapA mutations encoding lysine-insensitive dihydrodipicolinate synthase.	Lysine	32-38	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Glycine max	51-79
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	27-34	RD3 regulator of GUCY2D	Homo sapiens	71-74
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	27-34	small ubiquitin like modifier 2	Homo sapiens	188-194
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	36-39	RD3 regulator of GUCY2D	Homo sapiens	71-74
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	36-39	small ubiquitin like modifier 2	Homo sapiens	188-194
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	49-52	RD3 regulator of GUCY2D	Homo sapiens	71-74
18211901-6	2008	We show that two conserved lysines, Lys(756) and Lys(1154), located in RD3 and RD4, respectively, are subject to reversible SUMOylation, with SUMO-1 being more efficiently conjugated than SUMO-2.	Lysine	49-52	small ubiquitin like modifier 2	Homo sapiens	188-194
9106516-1	1997	In plants, the rate-limiting step in the pathway for lysine synthesis is catalyzed by the enzyme dihydrodipicolinate synthase (DS), which is encoded by the DapA gene.	Lysine	53-59	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Glycine max	97-125
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	96-99	NUAK family kinase 1	Homo sapiens	66-71
9047300-1	1997	A 19-amino acid residue peptide, Gly-Trp-Leu-Lys-Ile-Lys-Ala-Ala-Met-Arg-Trp-Gly-Phe-Phe-Val-Arg-Lys-Lys- Ala, corresponding to the basic amphiphilic alpha-helix (BAA) motif at the C-terminus of a recombinant tobacco calmodulin-binding protein, TCB60, was synthesized.	Lysine	53-56	calmodulin-binding protein 60 B-like	Nicotiana tabacum	245-250
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	NUAK family kinase 1	Homo sapiens	66-71
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	NUAK family kinase 1	Homo sapiens	66-71
18254724-5	2008	Topological analysis revealed that ubiquitin monomers attached to NUAK1 and MARK4 are linked by Lys(29) and/or Lys(33) rather than the more common Lys(48)/Lys(63).	Lysine	111-114	NUAK family kinase 1	Homo sapiens	66-71
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	171-174	NUAK family kinase 1	Homo sapiens	50-55
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	171-174	ubiquitin specific peptidase 9 X-linked	Homo sapiens	84-89
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	179-182	NUAK family kinase 1	Homo sapiens	50-55
18254724-8	2008	The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains.	Lysine	179-182	ubiquitin specific peptidase 9 X-linked	Homo sapiens	84-89
9047300-1	1997	A 19-amino acid residue peptide, Gly-Trp-Leu-Lys-Ile-Lys-Ala-Ala-Met-Arg-Trp-Gly-Phe-Phe-Val-Arg-Lys-Lys- Ala, corresponding to the basic amphiphilic alpha-helix (BAA) motif at the C-terminus of a recombinant tobacco calmodulin-binding protein, TCB60, was synthesized.	Lysine	53-56	calmodulin-binding protein 60 B-like	Nicotiana tabacum	245-250
9020087-0	1997	Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase.	Lysine	0-6	CD38 molecule	Homo sapiens	14-18
9020087-6	1997	Sequence analysis of the lysylendopeptidase-digested fragment of the labeled CD38 indicated that the FSBA-labeled residue was Lys-129.	Lysine	126-129	CD38 molecule	Homo sapiens	77-81
18358708-3	2008	Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased HDAC1-C/EBPbeta interaction upon GCN5-mediated lysine acetylation, and the ability of sumoylation to inhibit C/EBPalpha-SWI/SNF interaction.	Lysine	180-186	lysine acetyltransferase 2A	Homo sapiens	166-170
9020087-7	1997	We introduced site-directed mutations to change the Lys-129 of CD38 to Ala and to Arg.	Lysine	52-55	CD38 molecule	Homo sapiens	63-67
9020087-10	1997	These results indicate that Lys-129 of CD38 participates in cADPR binding and that ATP competes with cADPR for the binding site, resulting in the inhibition of the cADPR hydrolase activity of CD38.	Lysine	28-31	CD38 molecule	Homo sapiens	39-43
18344984-6	2008	We have further shown that the unphosphorylated or "transcriptionally inactive" form of STAT92E is localized on heterochromatin in association with HP1, and is required for stabilizing HP1 localization and histone H3 Lys 9 methylation (H3mK9) .	Lysine	217-220	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	88-95
9020087-10	1997	These results indicate that Lys-129 of CD38 participates in cADPR binding and that ATP competes with cADPR for the binding site, resulting in the inhibition of the cADPR hydrolase activity of CD38.	Lysine	28-31	CD38 molecule	Homo sapiens	192-196
9685993-5	1997	The aminopeptidase B component is a 72 kDa metalloexopeptidase which is able to remove Lys and Arg residues from naphtylamide derivatives and from the N-terminus of various peptide substrates.	Lysine	87-90	arginyl aminopeptidase	Rattus norvegicus	4-20
18305211-0	2008	Iron-induced turnover of the Arabidopsis IRON-REGULATED TRANSPORTER1 metal transporter requires lysine residues.	Lysine	96-102	iron-regulated transporter 1	Arabidopsis thaliana	41-68
18211824-3	2008	Substitutions of three lysine residues of NORE1A NES to alanines (L372, 376, 379A) showed its localization to the dot structures of the nucleus, which was similar to the NORE1A localizations observed after the administration to cells of Leptomycin B, a nuclear export inhibitor.	Lysine	23-29	Ras association domain family member 5	Homo sapiens	42-48
9058203-5	1997	Commercially available human beta 2-GPI is known to be selectively cleaved between Lys 317 and Thr 318.	Lysine	83-86	apolipoprotein H	Homo sapiens	29-39
18252252-0	2008	The Arabidopsis SDG4 contributes to the regulation of pollen tube growth by methylation of histone H3 lysines 4 and 36 in mature pollen.	Lysine	102-109	SET domain group 4	Arabidopsis thaliana	16-20
18252252-8	2008	Our results indicate that SDG4 is capable of modulating the expression of genes that function in the growth of pollen tube by methylation of specific lysine residues of the histone H3 in the vegetative nuclei.	Lysine	150-156	SET domain group 4	Arabidopsis thaliana	26-30
9656367-5	1997	Amino acid sequence of p32 contains Lys-Glu-Lys (KEK) motif which is one of tripeptide necessary for malaria parasite to invade erythrocytes.	Lysine	36-39	retinol dehydrogenase 5	Bos taurus	23-26
18339843-4	2008	This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/beta-catenin signaling, E-cadherin, and integrin beta1 through ASH1-mediated deacetylation and repressive trimethylation of lysine 27 (H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin.	Lysine	203-209	integrin subunit beta 1	Homo sapiens	119-133
9656367-5	1997	Amino acid sequence of p32 contains Lys-Glu-Lys (KEK) motif which is one of tripeptide necessary for malaria parasite to invade erythrocytes.	Lysine	44-47	retinol dehydrogenase 5	Bos taurus	23-26
8910518-5	1996	The ubiquitin molecule that anchors the chain is transferred to this lysine from the active site of the same UBC1 molecule.	Lysine	69-75	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	109-113
18329615-3	2008	Tat directly interacts with the deacetylase domain of SIRT1 and blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of NF-kappaB.	Lysine	107-113	sirtuin 1	Homo sapiens	54-59
18329615-3	2008	Tat directly interacts with the deacetylase domain of SIRT1 and blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of NF-kappaB.	Lysine	107-113	sirtuin 1	Homo sapiens	86-91
8910518-6	1996	When the tail of UBC1 is deleted, the catalytic domain synthesizes a chain that consists of ubiquitin molecules uniformly linked to one another via lysine 48.	Lysine	148-154	E2 ubiquitin-conjugating protein UBC1	Saccharomyces cerevisiae S288C	17-21
8910316-5	1996	The epsilon-amino group of lysine (Lys172) of the human B2 receptor provides the only primary amino group within this receptor fragment.	Lysine	27-33	bradykinin receptor B2	Homo sapiens	56-67
18366812-6	2008	RESULTS: Our results demonstrate that histone H3 tri-methylated at lysine 9 (H3K9me3), a hallmark of constitutive heterochromatin, as well as the chromatin remodeling protein ATRX remained associated with pericentric heterochromatin regions in spite of their extensive hypo-methylation.	Lysine	67-73	ATRX, chromatin remodeler	Mus musculus	175-179
8930296-2	1996	This is the first in vivo electrophysiological evidence demonstrating the effects of Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln (nociceptin or orphanin FQ), an endogenous ligand for the orphan ORL1 receptor, on nociceptive neurons in the CNS.	Lysine	117-120	prepronociceptin	Rattus norvegicus	154-164
27264152-0	2008	First observation of Hb D-Ouled Rabah [beta19(B1)Asn&gt;Lys] in the Turkish population.	Lysine	56-59	HBD	Homo sapiens	21-25
27264152-1	2008	Hb D-Ouled Rabah [beta19(B1)Asn&gt;Lys] is a rare hemoglobin (Hb) beta chain variant reported from Tuareg tribes in Algeria and once from China.	Lysine	35-38	HBD	Homo sapiens	0-4
8930296-2	1996	This is the first in vivo electrophysiological evidence demonstrating the effects of Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln (nociceptin or orphanin FQ), an endogenous ligand for the orphan ORL1 receptor, on nociceptive neurons in the CNS.	Lysine	117-120	prepronociceptin	Rattus norvegicus	168-179
8897697-8	1996	The peptide analogs of TF possessed the WKS motif, the double lysine residues or other regions of TF.	Lysine	62-68	coagulation factor III, tissue factor	Homo sapiens	23-25
18320574-4	2008	Here, we have analyzed whether beta-lactoglobulin (bLG) or human serum albumin (HSA) modified chemically to contain only CML (10-40% lysine modification) can (i) interact with RAGE in vitro and (ii) interact with and activate RAGE in lung epithelial cells.	Lysine	133-139	long intergenic non-protein coding RNA 914	Homo sapiens	176-180
8806601-5	1996	Cow 11-cis retinol dehydrogenase has threonine-61 at the position homologous to lysine-64.	Lysine	80-86	retinol dehydrogenase 5	Bos taurus	4-32
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	292-295	nucleoporin 62	Homo sapiens	38-41
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	292-295	nucleoporin 62	Homo sapiens	186-189
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	292-295	nucleoporin 62	Homo sapiens	186-189
9064351-4	1996	It has been reported that protection from NK1 killers depended on the presence of the Lys residue at position 80, an upward pointing residue near the end of the alpha 1 helix (and not on Asn77), whereas inhibition of NK2 effector cells required Ser77, a residue deep in the F pocket and interacting with the peptide (and not Asn80).	Lysine	86-89	tachykinin receptor 1	Homo sapiens	42-45
8702852-0	1996	Requirement of lysine residues outside of the proposed pentasaccharide binding region for high affinity heparin binding and activation of human antithrombin III.	Lysine	15-21	serpin family C member 1	Homo sapiens	144-160
17551969-8	2008	Both Tip60 and DN-Ubc9 increase transactivation activity of wild-type but not the sumoylation deficient form of PLAGL2 (K250, 269, 356R), indicating that Tip60 acetylates PLAGL2 and abolishes the sumoylation of PLAGL2 possibly through modification of the same lysine residues (K250, 269, 356) within PLAGL2.	Lysine	260-266	lysine acetyltransferase 5	Homo sapiens	5-10
17551969-8	2008	Both Tip60 and DN-Ubc9 increase transactivation activity of wild-type but not the sumoylation deficient form of PLAGL2 (K250, 269, 356R), indicating that Tip60 acetylates PLAGL2 and abolishes the sumoylation of PLAGL2 possibly through modification of the same lysine residues (K250, 269, 356) within PLAGL2.	Lysine	260-266	lysine acetyltransferase 5	Homo sapiens	154-159
8701955-0	1996	Direct detection of Hb C (B6 Glu-Lys) by BseRI analysis.	Lysine	33-36	keratin 88, pseudogene	Homo sapiens	20-24
18201693-5	2008	Mutation of the SUMO-acceptor lysines in Bach2 alters the behavior of these nuclear foci and results in a decreased frequency of fusion events.	Lysine	30-37	BTB domain and CNC homolog 2	Homo sapiens	41-46
18235233-4	2008	The 500 kD precursor MLL undergoes evolutionarily conserved site-specific cleavage mediated by Taspase1, generating the mature MLL(N320/C180) heterodimer which methylates histone H3 at lysine 4 with its carboxy-terminal SET domain.	Lysine	185-191	taspase 1	Homo sapiens	95-103
8765026-10	1996	Similar to p50 molecules, the KKA3-encoded molecules are characterized by two extracellular immunoglobulin-like domains, by the presence of a lysine in the transmembrane region and a short (39 amino acids) cytoplasmic tail which does not contain immune receptor tyrosine-based activation motifs (ITAM)-like sequences.	Lysine	142-148	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4	Homo sapiens	30-34
18256186-8	2008	We conclude that self-assembling amphiphiles of lysine-rich RSH extensin form positively charged scaffolds in the cell plate.	Lysine	48-54	extensin 3	Arabidopsis thaliana	60-63
8706746-0	1996	An essential lysine in the substrate-binding site of ornithine carbamoyltransferase.	Lysine	13-19	ornithine transcarbamylase	Homo sapiens	53-83
17704809-4	2008	The initial step of this pathway involves UV-induced association of TIP60 with SUMO-conjugation enzymes and site-specific sumoylation of TIP60 at lysines 430 and 451 via Ubc9.	Lysine	146-153	lysine acetyltransferase 5	Homo sapiens	68-73
17704809-4	2008	The initial step of this pathway involves UV-induced association of TIP60 with SUMO-conjugation enzymes and site-specific sumoylation of TIP60 at lysines 430 and 451 via Ubc9.	Lysine	146-153	lysine acetyltransferase 5	Homo sapiens	137-142
18055523-8	2008	CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide.	Lysine	86-88	intercellular adhesion molecule 1	Homo sapiens	30-36
8663233-11	1996	A peptide corresponding to the carboxyl-terminal 20 amino acids of Ret dissociated Enigma and Ret complexes, while a mutant that changed Asn-Lys-Leu-Tyr in the peptide to Ala-Lys-Leu-Ala or a peptide corresponding to exon16 of InsR failed to disrupt the complexes, indicating the Asn-Lys-Leu-Tyr sequence of Ret is essential to the recognition motif for LIM2 of Enigma.	Lysine	141-144	ret proto-oncogene	Homo sapiens	67-70
8663248-4	1996	The SL15 protein has a predicted molecular weight of 26,693 with two potential membrane spanning regions and a likely C-terminal endoplasmic reticulum retention signal (Lys-Lys-Glu-Gln).	Lysine	169-172	mannose-P-dolichol utilization defect 1 protein	Cricetulus griseus	4-8
18361930-1	2008	Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant rejection, and diabetes.	Lysine	201-207	intercellular adhesion molecule 1	Homo sapiens	63-103
8663248-4	1996	The SL15 protein has a predicted molecular weight of 26,693 with two potential membrane spanning regions and a likely C-terminal endoplasmic reticulum retention signal (Lys-Lys-Glu-Gln).	Lysine	173-176	mannose-P-dolichol utilization defect 1 protein	Cricetulus griseus	4-8
18281509-4	2008	We show that AG regulatory sequences are required for its ectopic expression in both emf1 and emf2 mutants and that EMF2 is required for trimethylation of histone 3 lysine 27 on the AG chromatin.	Lysine	165-171	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	182-184
8767485-10	1996	The Arg/Lys sequence at position 25-30, which resembles the binding site of apoE, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor efficiently.	Lysine	8-11	lactotransferrin	Rattus norvegicus	123-134
18036349-4	2008	An important regulatory mechanism of this complex is through acetylation and SIRT1-mediated lysine de-acetylation under low nutrient conditions.	Lysine	92-98	sirtuin 1	Homo sapiens	77-82
8636149-7	1996	In contrast, CHO cells expressing an insulin receptor mutated at the ATP binding site (Lys-1030 --&gt; Arg) showed no insulin-stimulated autophosphorylation or phosphorylation of IRS-1.	Lysine	87-90	insulin receptor	Cricetulus griseus	37-53
8615753-12	1996	The results are in contradiction with the SWISS-PROT and GenBank rat liver GST 1 cDNA-sequencing data, which give a lysine and a methionine at the corresponding positions.	Lysine	116-122	carbohydrate sulfotransferase 1	Rattus norvegicus	75-80
18202552-7	2008	Mutagenesis of Lys residues identified in vitro indicates that site-specific Ubc4-dependent Chf protein autoubiquitination is responsible for Chf protein turnover.	Lysine	15-18	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	77-81
18007656-3	2008	We show that RAD16 is required for ultraviolet-dependent hyperacetylation of histone H3 (Lys 9 and Lys 14) at the MFA2 promoter and throughout the genome.	Lysine	89-92	mating pheromone a	Saccharomyces cerevisiae S288C	114-118
8635471-7	1996	In contrast to the nuclear import of L5, import of TFIIIA is sensitive towards the nuclear localization sequence (NLS) competitor p(lys)-BSA, suggesting that these two proteins make use of different import pathways.	Lysine	132-135	general transcription factor 3A L homeolog	Xenopus laevis	51-57
18173750-2	2008	In humans, the conventional Rad51 (HsRad51) protein has a Lys residue at position 313; however, the HsRad51-Q313 protein, in which the Lys313 residue is replaced by Gln, was reported as an isoform, probably corresponding to a polymorphic variant.	Lysine	58-61	RAD51 recombinase	Homo sapiens	28-33
8646816-0	1996	Stabilization of plasmin by lysine derivatives.	Lysine	28-34	plasminogen	Bos taurus	17-24
17959748-3	2008	In circular muscle strips, indomethacin enhanced contractile responses to NKA (p &lt; 0.01) and to the NK(2) receptor-selective agonist [Lys(5),MeLeu(9),Nle(10)]-NKA(4-10) (p &lt; 0.05) in both normal and acute diverticular disease (DD) specimens, indicating NK(2) receptor-mediated release of relaxant prostanoids.	Lysine	137-140	tachykinin receptor 2	Homo sapiens	103-117
8646816-2	1996	Since plasmin has lysine binding site in its heavy chain, lysine derivatives react with plasmin and then modify its activity.	Lysine	18-24	plasminogen	Bos taurus	6-13
8646816-2	1996	Since plasmin has lysine binding site in its heavy chain, lysine derivatives react with plasmin and then modify its activity.	Lysine	18-24	plasminogen	Bos taurus	88-95
8646816-2	1996	Since plasmin has lysine binding site in its heavy chain, lysine derivatives react with plasmin and then modify its activity.	Lysine	58-64	plasminogen	Bos taurus	6-13
8646816-2	1996	Since plasmin has lysine binding site in its heavy chain, lysine derivatives react with plasmin and then modify its activity.	Lysine	58-64	plasminogen	Bos taurus	88-95
8646816-3	1996	The effects of lysine derivatives such as epsilon-aminocaproic acid (EACA) and tranexamic acid on bovine plasmin activity were investigated.	Lysine	15-21	plasminogen	Bos taurus	105-112
18373253-2	2008	Characteristic mass shifts and fragment ions indicating ubiquitinated lysine residues in tryptic and gluC digests are discussed.	Lysine	70-76	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	101-105
8646816-4	1996	In the absence of lysine derivatives, the bovine plasmin activity which was evaluated as the amidolytic activity was reduced in a time- or temperature-dependent manner.	Lysine	18-24	plasminogen	Bos taurus	49-56
8603692-0	1996	Characterisation of human cdc2 lysine 33 mutations expressed in the fission yeast Schizosaccharomyces pombe.	Lysine	31-37	cyclin dependent kinase 1	Homo sapiens	26-30
18158948-5	2008	The resulting pz-alpha-MSH analog reacted with the fac-[(99m)Tc(CO)(3)](+) moiety, giving [Ac-Nle(4),Asp(5),d-Phe(7),Lys(11)(pz-(99m)Tc(CO)(3))]alpha-MSH(4-11) in high yield, high specific activity and high radiochemical purity.	Lysine	117-120	msh homeobox 1	Mus musculus	23-26
19112497-8	2008	Lysine-deficient TRAF6 also rescued RANKL-mediated NFkappaB and MAPK activation, and osteoclastogenesis in retrovirally-rescued TRAF6-deficient bone marrow macrophages.	Lysine	0-6	TNF superfamily member 11	Homo sapiens	36-41
8603692-2	1996	We report the biochemical characterisation of two substitutions of human cdc2 at lysine 33, a residue involved in nucleotide binding, that differently alter the fission yeast cell cycle.	Lysine	81-87	cyclin dependent kinase 1	Homo sapiens	73-77
18042685-8	2008	Using a series of mutants on the HBPE, we identified the most important amino acids involved in zymogen/Ixolaris interaction-Arg-93 &gt;&gt;&gt; Arg-165 &gt; or = Lys-169 &gt; Lys-236 &gt; Arg-125-which was identical to that observed for FXa/Ixolaris interaction.	Lysine	163-166	coagulation factor X	Homo sapiens	238-241
18042685-8	2008	Using a series of mutants on the HBPE, we identified the most important amino acids involved in zymogen/Ixolaris interaction-Arg-93 &gt;&gt;&gt; Arg-165 &gt; or = Lys-169 &gt; Lys-236 &gt; Arg-125-which was identical to that observed for FXa/Ixolaris interaction.	Lysine	176-179	coagulation factor X	Homo sapiens	238-241
8551566-10	1996	We have now determined that the substitution of a single amino acid residue, glutamic acid, for the lysine residue at position 522 in the fourth extracellular region of the PiT2 protein is sufficient to render PiT2 functional as a GALV receptor.	Lysine	100-106	solute carrier family 20 member 2	Homo sapiens	173-177
8551566-10	1996	We have now determined that the substitution of a single amino acid residue, glutamic acid, for the lysine residue at position 522 in the fourth extracellular region of the PiT2 protein is sufficient to render PiT2 functional as a GALV receptor.	Lysine	100-106	solute carrier family 20 member 2	Homo sapiens	210-214
18000034-4	2008	Within the QUA2 domain, a transposition of adjacent arginine and lysine residues is primarily responsible for the switch in RNA binding between BBP and SF1.	Lysine	65-71	splicing factor 1	Homo sapiens	152-155
8815576-0	1996	The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va. A functionally defective protein C (PC)-Mie, detected the plasma of a patient with hereditary thrombophilia, has Lys substituted for gamma-carboxyglutamic acid (Gla)26 residue.	Lysine	280-283	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	21-30
17977840-0	2007	Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.	Lysine	145-151	protein kinase MEC1	Saccharomyces cerevisiae S288C	21-25
17951578-5	2007	Interestingly, propionyl- and butyryl-lysine peptides were found to bind tighter to Hst2 compared with acetyl-lysine peptide and showed measurable rates of catalysis with Hst2, Sirt1, Sirt2, and Sirt3, suggesting propionyl- and butyryl-lysine proteins may be sirtuin substrates in vivo.	Lysine	38-44	sirtuin 1	Homo sapiens	177-182
9010602-10	1996	Only one of these regions is polar and highly hydrated in unbound hemoprotein; 2) interactions of the polar regions of 2B4 and NCPR are necessary to bring CPM-labelled cysteine of NCPR in short distance of the heme of 2B4; and 3) some of the lysine residues located in the proximity of the polar binding regions are apparently involved in the formation of the internal salt bridges in the molecule of 2B4.	Lysine	242-248	CD244 molecule	Homo sapiens	119-122
17991829-5	2007	TRAF3 is an E3 ubiquitin ligase that preferentially assembled lysine-63-linked polyubiquitin chains.	Lysine	62-68	TNF receptor associated factor 3	Homo sapiens	0-5
17991829-6	2007	DUBA selectively cleaved the lysine-63-linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signaling complex containing TANK-binding kinase 1.	Lysine	29-35	TNF receptor associated factor 3	Homo sapiens	70-75
17991879-2	2007	In a yeast 2-hybrid screen for proteins that interact with myocardin-related transcription factor-A (MRTF-A), we identified the histone 3 lysine 9 (H3K9)-specific demethylase, Jmjd1a.	Lysine	138-144	myocardin related transcription factor A	Mus musculus	101-107
17991879-2	2007	In a yeast 2-hybrid screen for proteins that interact with myocardin-related transcription factor-A (MRTF-A), we identified the histone 3 lysine 9 (H3K9)-specific demethylase, Jmjd1a.	Lysine	138-144	lysine (K)-specific demethylase 3A	Mus musculus	176-182
9010602-10	1996	Only one of these regions is polar and highly hydrated in unbound hemoprotein; 2) interactions of the polar regions of 2B4 and NCPR are necessary to bring CPM-labelled cysteine of NCPR in short distance of the heme of 2B4; and 3) some of the lysine residues located in the proximity of the polar binding regions are apparently involved in the formation of the internal salt bridges in the molecule of 2B4.	Lysine	242-248	CD244 molecule	Homo sapiens	218-221
9010602-10	1996	Only one of these regions is polar and highly hydrated in unbound hemoprotein; 2) interactions of the polar regions of 2B4 and NCPR are necessary to bring CPM-labelled cysteine of NCPR in short distance of the heme of 2B4; and 3) some of the lysine residues located in the proximity of the polar binding regions are apparently involved in the formation of the internal salt bridges in the molecule of 2B4.	Lysine	242-248	CD244 molecule	Homo sapiens	218-221
8675763-7	1995	Mean increase of milk protein yield was 46 g/d with Met plus Lys, and mean increase of true protein content was 1.1 g/kg of milk.	Lysine	61-64	PY	Bos taurus	17-35
7578077-1	1995	Posttranslational modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A) is essential for cell viability and proliferation.	Lysine	45-51	eukaryotic translation initiation factor 5A	Homo sapiens	63-94
17891388-6	2007	The alpha-amylase activity using raw corn starch was more than 2.5 times higher than that using glucose as the sole carbon source during L-lysine fermentation.	Lysine	137-145	alpha-amylase	Zea mays	4-17
17923702-6	2007	Furthermore, lysine 3016 of ATM is a substrate in vitro for the Tip60 histone acetyltransferase.	Lysine	13-19	lysine acetyltransferase 5	Homo sapiens	64-69
17923702-9	2007	The acetylation of ATM on lysine 3016 by Tip60 is therefore a key step linking the detection of DNA damage and the activation of ATM kinase activity.	Lysine	26-32	lysine acetyltransferase 5	Homo sapiens	41-46
7578077-1	1995	Posttranslational modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A) is essential for cell viability and proliferation.	Lysine	45-51	eukaryotic translation initiation factor 5A	Homo sapiens	96-102
20641555-17	2004	To improve the tumor/kidney uptake ratio, the same group of researchers designed a short linear alpha-MSH analog, NAPamide, with a net charge of +1 and DOTA conjugated to the C-terminal lysine (1).	Lysine	186-192	msh homeobox 1	Mus musculus	102-105
7578077-10	1995	In contrast to the main form, all three minor isoforms of eIF-5A are characterized by acetylation of the epsilon-amino group of lysine at position 47.	Lysine	128-134	eukaryotic translation initiation factor 5A	Homo sapiens	58-64
7592935-4	1995	When Rab5 is translated in the presence of biotin-lysine-tRNA, it incorporates biotin-lysine into its peptide backbone and is efficiently prenylated; since this modification is dependent on guanine nucleotide binding, biotin-Rab5"s functional integrity must be maintained.	Lysine	50-56	RAB5A, member RAS oncogene family	Homo sapiens	5-9
18004385-7	2007	Here we show that the mammalian histone methyltransferase SUV39H1 is itself targeted by the histone deacetylase SIRT1 and that SUV39H1 activity is regulated by acetylation at lysine residue 266 in its catalytic SET domain.	Lysine	175-181	sirtuin 1	Homo sapiens	112-117
17620057-8	2007	Deacetylated lysine residues within Rb formed a domain similar to the SIRT1-targeted domain of the p53 tumour suppressor protein.	Lysine	13-19	sirtuin 1	Homo sapiens	70-75
7592935-4	1995	When Rab5 is translated in the presence of biotin-lysine-tRNA, it incorporates biotin-lysine into its peptide backbone and is efficiently prenylated; since this modification is dependent on guanine nucleotide binding, biotin-Rab5"s functional integrity must be maintained.	Lysine	50-56	RAB5A, member RAS oncogene family	Homo sapiens	225-229
8749321-8	1995	Mass spectrometric analysis by Frit-FAB MS of the fragments generated from horse heart cytochrome c presented unambiguous evidence to corroborate the specificity of MEP for acyl-lysine bonds.	Lysine	178-184	cytochrome c, somatic	Equus caballus	87-99
17875926-1	2007	In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji class.	Lysine	28-34	lysine demethylase 1A	Homo sapiens	95-99
17875926-1	2007	In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji class.	Lysine	28-34	lysine demethylase 1A	Homo sapiens	100-106
17934453-3	2007	Our study identifies a novel post-translational modification of SIRT1, namely sumoylation at Lys 734.	Lysine	93-96	sirtuin 1	Homo sapiens	64-69
17934453-5	2007	Conversely, mutation of SIRT1 at Lys 734 or desumoylation by SENP1, a nuclear desumoylase, reduced its deacetylase activity.	Lysine	33-36	sirtuin 1	Homo sapiens	24-29
7473721-6	1995	Our results indicate that heavy-chain framework residues alanine at H71 and lysine at H93 of the chimeric B72.3 antibody are the major determinants of the conformation of heavy-chain CDR2/CDR1 and CDR3 loops, whereas the salt-bridge between lysine at H73 and aspartic acid at H55 is less important.	Lysine	76-82	cerebellar degeneration related protein 1	Homo sapiens	188-192
17924656-8	2007	Focusing on BMP-3"s preference for ActRIIb, we find that Lys-76 of ActRII and the structurally equivalent Glu-76 of ActRIIb are distinct between the two receptors.	Lysine	57-60	activin A receptor type 2B	Homo sapiens	35-42
7548152-1	1995	Although 13 lysines of horse cytochrome c are invariant, and three more are extremely conserved, the modification of their side-chain epsilon-amino groups by beta-thiopropionylation caused important changes in protein properties for only three of them; lysines 72,73 and 79.	Lysine	12-19	cytochrome c, somatic	Equus caballus	29-41
17937819-5	2007	Replacement of cytosolic lysine residues reduced but did not prevent Vpu-mediated CD4 degradation and ubiquitination, suggesting that Vpu-mediated CD4 degradation is not entirely dependent on the ubiquitination of cytosolic lysines and as such might also involve ubiquitination of other sites.	Lysine	25-31	Vpu	Human immunodeficiency virus 1	134-137
7548152-1	1995	Although 13 lysines of horse cytochrome c are invariant, and three more are extremely conserved, the modification of their side-chain epsilon-amino groups by beta-thiopropionylation caused important changes in protein properties for only three of them; lysines 72,73 and 79.	Lysine	253-260	cytochrome c, somatic	Equus caballus	29-41
7673234-2	1995	We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity.	Lysine	41-44	interleukin 1 receptor antagonist	Homo sapiens	56-80
17923864-8	2007	Thus, we identified JMJD3 as a demethylase capable of removing the trimethyl group from histone H3 lysine 27 and upregulated in prostate cancer.	Lysine	99-105	lysine demethylase 6B	Homo sapiens	20-25
17680815-2	2007	Hb Stanleyville II is characterized by a single base exchange (AAC--&gt;AAA) resulting in a substitution Asn --&gt; Lys at position 78 of hemoglobin alpha2-chain.	Lysine	116-119	glycine-N-acyltransferase	Homo sapiens	63-66
7673234-2	1995	We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity.	Lysine	41-44	interleukin 1 receptor antagonist	Homo sapiens	82-88
7673234-2	1995	We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist activity.	Lysine	41-44	interleukin 1 receptor antagonist	Homo sapiens	122-128
7670751-2	1995	It is now apparent that apolipoprotein (a) is not only size but also sequence polymorphic and that some of the mutations within the lysine-binding site potentially impair the binding of apolipoprotein (a) to lysine-rich domains, such as those in fibrin(ogen) and apolipoprotein B100.	Lysine	132-138	apolipoprotein B	Mus musculus	263-282
17682057-4	2007	We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNMT1) complexes to Cyp1a1 promoter chromatin and inhibits histone marks induced by AHR-mediated gene transactivation, including phosphorylation of histone H3 Ser-10, trimethylation of H3 Lys-4, and various acetylation marks in histones H3 and H4.	Lysine	275-278	DNA methyltransferase 1	Homo sapiens	56-79
17682057-4	2007	We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNMT1) complexes to Cyp1a1 promoter chromatin and inhibits histone marks induced by AHR-mediated gene transactivation, including phosphorylation of histone H3 Ser-10, trimethylation of H3 Lys-4, and various acetylation marks in histones H3 and H4.	Lysine	275-278	DNA methyltransferase 1	Homo sapiens	87-92
8543567-2	1995	The amino acid sequence of its NH2-terminus was determined to be Val-Pro-Asn-Ser-Leu-Asp-Trp-Arg-Glu-Lys-Gly-Tyr-Val-Thr-Pro-, which differed from that of rat cathepsin L and was not found in the amino acid sequence data bank.	Lysine	101-104	cathepsin L	Rattus norvegicus	159-170
17937921-4	2007	By analyzing residues surrounding the ligand side chain, partner ligands were identified for various FFRPs from Pyrococcus, e.g., lysine facilitates homo-octamerization of FL11, and arginine facilitates hetero-octamerization of FL11 and DM1.	Lysine	130-136	DM1 protein kinase	Homo sapiens	237-240
17937921-5	2007	Transcription of the fl11 gene and lysine synthesis are regulated by shifting the equilibrium between association states of FL11 and by shifting the equilibrium toward association with DM1, in response to amino acid availability.	Lysine	35-41	DM1 protein kinase	Homo sapiens	185-188
7622036-9	1995	These results indicate that the lysine-dependent function of histone H4 is required for the maintenance of genome integrity, and that DNA damage resulting from the loss of this function activates the RAD9-dependent G2/M checkpoint pathway.	Lysine	32-38	chromatin-binding protein RAD9	Saccharomyces cerevisiae S288C	200-204
17690098-0	2007	Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.	Lysine	15-21	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	52-58
17690098-0	2007	Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.	Lysine	15-21	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	76-80
17690098-1	2007	In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex, with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification.	Lysine	44-50	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	83-89
17690098-1	2007	In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex, with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification.	Lysine	44-50	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	142-148
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	Lysine	20-23	interleukin 1 alpha	Homo sapiens	136-159
17690098-1	2007	In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex, with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification.	Lysine	44-50	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	200-204
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	4-10	transient receptor potential cation channel subfamily M member 2	Homo sapiens	127-132
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	4-10	transient receptor potential cation channel subfamily M member 2	Homo sapiens	194-199
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	75-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	127-132
17604279-8	2007	The lysine in S6 was responsible for the anion selectivity; insertion of a lysine into corresponding sites within S6 of either TRPM2 or TRPM8 created anion channels that were activated by ADPR (TRPM2 I1045K) or by cold temperatures (TRPM8 V976K).	Lysine	75-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	194-199
7718874-4	1995	Although the MLL gene was alternatively spliced, the fusion protein should contain an N-terminal half of the MLL, including AT hook motifs, that is fused to the MEN protein with a lysine-rich sequence, suggesting that the MLL/MEN fusion protein could be a chimeric transcription factor.	Lysine	180-186	lysine methyltransferase 2A	Homo sapiens	13-16
17604279-9	2007	The positive charge of the lysine was decisive for the glutamate block because the mutant TRPM2 I1045H displayed cation currents that were blocked at acidic but not alkaline intracellular pH values.	Lysine	27-33	transient receptor potential cation channel subfamily M member 2	Homo sapiens	90-95
17644059-4	2007	For the optimized substrate T-Abu-Q, with sequence Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-Abu-Psi(COO)Ala-Ser-Lys(QSY-7)-amide, the kinetic parameters with HCV NS3 protease are K(m)=30 microM, k(cat)=0.6s(-1), and k(cat)/K(m)=20,100s(-1)M(-1).	Lysine	62-65	KRAS proto-oncogene, GTPase	Homo sapiens	151-154
7787788-0	1995	[The effect of methylating lysine residues on properties of complexes of myosin subfragment-1 with ADP and phosphate analogs].	Lysine	27-33	myosin heavy chain 14	Homo sapiens	73-79
17636259-6	2007	We mutated Arg(47) of the Sdh3p subunit to Cys, Glu, and Lys and Asp(88) of the Sdh4p subunit to Asn, Glu, and Lys.	Lysine	111-114	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	80-85
7706481-5	1995	MBP and poly-L-lysine induced an increase in airway responsiveness, which was inhibited by pretreatment with a selective BK-2 receptor antagonist, NPC 17713 (250 micrograms/ml).	Lysine	8-21	bradykinin receptor B2	Homo sapiens	121-134
17080300-4	2007	This allele differs from the remaining b-like alleles (designated b"), as well as all other Gp-9 alleles, by encoding a lysine at position 151 in the protein product, suggesting that this substitution is responsible for its deleterious effects.	Lysine	120-126	pheromone-binding protein Gp-9	Solenopsis invicta	92-96
17080300-7	2007	While we cannot entirely rule out involvement of other genes in complete gametic disequilibrium with Gp-9, our data are consistent with the hypothesis that the Lys(151) residue in GP-9 protein confers the deleterious effects of the b allele in homozygous condition, possibly by impairing the protein"s function through interference with ligand binding/release or hindrance of dimer formation.	Lysine	160-163	pheromone-binding protein Gp-9	Solenopsis invicta	180-184
17726178-2	2007	The PB1 domains adopt a ubiquitin-like beta-grasp fold, containing two alpha helices and a mixed five-stranded beta sheet, and are classified into groups harboring an acidic OPCA motif (type I), the invariant lysine residue on the first beta strand (type II), or both (type I/II).	Lysine	209-215	submaxillary gland androgen regulated protein 3A	Homo sapiens	4-7
7711105-7	1995	A further advantage of this branched mPEG lies in the possibility of a precise evaluation of the number of polymer molecules bound to the proteins; upon acid hydrolysis, each molecule of mPEG2 releases a molecule of lysine which can be detected by amino acid analysis.	Lysine	216-222	insulin-like growth factor 2	Mus musculus	187-192
7527430-5	1994	Furthermore, pretreatment with either CP, 96-345, or RP-67580 two selective NK-1 receptor antagonists inhibited poly-L-lysine-induced airway hyperresponsiveness and plasma protein extravasation.	Lysine	112-125	tachykinin receptor 1	Homo sapiens	76-89
17726178-3	2007	The OPCA motif of a type I PB1 domain forms salt bridges with basic residues, especially the conserved lysine, of a type II PB1 domain, thereby mediating a specific PB1-PB1 heterodimerization, whereas additional contacts contribute to high affinity and specificity of the modular interaction.	Lysine	103-109	submaxillary gland androgen regulated protein 3A	Homo sapiens	27-30
17726178-3	2007	The OPCA motif of a type I PB1 domain forms salt bridges with basic residues, especially the conserved lysine, of a type II PB1 domain, thereby mediating a specific PB1-PB1 heterodimerization, whereas additional contacts contribute to high affinity and specificity of the modular interaction.	Lysine	103-109	submaxillary gland androgen regulated protein 3A	Homo sapiens	124-127
17726178-3	2007	The OPCA motif of a type I PB1 domain forms salt bridges with basic residues, especially the conserved lysine, of a type II PB1 domain, thereby mediating a specific PB1-PB1 heterodimerization, whereas additional contacts contribute to high affinity and specificity of the modular interaction.	Lysine	103-109	submaxillary gland androgen regulated protein 3A	Homo sapiens	165-172
17586528-3	2007	Recent findings suggest that the C2 domain of PKCalpha interacts specifically with phosphatidylinositols 4,5-bisphosphate (PtdIns(4,5)P(2)) through its lysine rich cluster, for which it shows higher affinity than for POPS.	Lysine	152-158	protein kinase C, alpha	Rattus norvegicus	46-54
7964517-5	1994	Thus, NK1.1+Ly-6ChiCD4+ T cells show flexibility in MHC class restriction, but their autoreactivity remains MHC dependent.	Lysine	12-14	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	6-11
17659281-2	2007	The structure of OTR revealed that the active site contains an unusual lysine-ligated heme, despite the presence of a CXXCH motif in the sequence that would predict histidine ligation.	Lysine	71-77	tetrathionate reductase family octaheme c-type cytochrome	Shewanella oneidensis MR-1	17-20
17659281-3	2007	This lysine ligation has been previously observed only in the pentaheme nitrite reductases, suggesting that OTR may have a possible role in nitrite reduction.	Lysine	5-11	tetrathionate reductase family octaheme c-type cytochrome	Shewanella oneidensis MR-1	108-111
7725796-3	1994	While replacement of lysine 744 abolished the function of the Pas1 protein in peroxisome biogenesis, replacement of lysine 467 had no obvious effect.	Lysine	21-27	AAA family ATPase peroxin 1	Saccharomyces cerevisiae S288C	62-66
17664295-2	2007	Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS.	Lysine	22-28	proliferating cell nuclear antigen	Mus musculus	73-77
7929297-2	1994	The biosynthesis of hypusine occurs posttranslationally in only this protein by modification of a single lysine residue (Lys50 in the human eIF-5A precursor).	Lysine	105-111	eukaryotic translation initiation factor 5A	Homo sapiens	140-146
17526739-9	2007	Importantly, we identified six lysine residues in the C-terminal domain of Rpb1 as ubiquitin acceptor sites mediated by Wwp2.	Lysine	31-37	polymerase (RNA) II (DNA directed) polypeptide A	Mus musculus	75-79
7945384-2	1994	Sequence analysis showed that PLC-alpha is highly conserved among rat, mouse, and calf and that it has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved in the mammals.	Lysine	127-130	protein disulfide isomerase associated 3	Mus musculus	30-39
17630506-1	2007	p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation.	Lysine	33-40	MDM2 proto-oncogene	Homo sapiens	44-48
17537733-1	2007	Histone demethylase LSD1 regulates transcription by demethylating Lys(4) of histone H3.	Lysine	66-69	lysine demethylase 1A	Homo sapiens	20-24
7945384-5	1994	PLC-alpha is supposed to be a member not of PLC superfamily but of Trp-Cys-Gly-His-Cys-Lys motif-containing proteins consisting of protein disulfide isomerase, P5, ERp72, and thioredoxin.	Lysine	87-90	protein disulfide isomerase associated 3	Mus musculus	0-9
7969034-6	1994	Moreover, Hypp from various eukaryotic species (slime mold, alfalfa and man) carries the lysine to hypusine modification when expressed in yeast and can substitute functionally for Hyp2p in strains disrupted for HYP2, indicating a highly conserved function of this protein.	Lysine	89-95	sodium voltage-gated channel alpha subunit 4	Homo sapiens	10-14
17584299-1	2007	G9a belongs to the subfamily of histone H3 lysine 9 (H3-K9)-specific methyltransferases.	Lysine	43-49	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
7969034-6	1994	Moreover, Hypp from various eukaryotic species (slime mold, alfalfa and man) carries the lysine to hypusine modification when expressed in yeast and can substitute functionally for Hyp2p in strains disrupted for HYP2, indicating a highly conserved function of this protein.	Lysine	89-95	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	212-216
8086429-0	1994	Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.	Lysine	94-100	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	125-179
17523162-9	2007	ABCB4-K435M and ABCB4-K1075M, Walker A lysine mutants, did not mediate the phospholipid and cholesterol efflux in the presence of taurocholate, suggesting that ATP hydrolysis is essential for the efflux.	Lysine	39-45	ATP binding cassette subfamily B member 4	Homo sapiens	0-5
17523162-9	2007	ABCB4-K435M and ABCB4-K1075M, Walker A lysine mutants, did not mediate the phospholipid and cholesterol efflux in the presence of taurocholate, suggesting that ATP hydrolysis is essential for the efflux.	Lysine	39-45	ATP binding cassette subfamily B member 4	Homo sapiens	16-21
8086429-10	1994	These results indicate that both tyrosine-151 and lysine-155 are required for 15-PGDH activity.	Lysine	50-56	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	78-85
8083750-5	1994	The first 10 amino acids of GAP-43, Met-Leu-Cys-Cys-Met-Arg-Arg-Thr-Lys-Gln, stimulate G(o).	Lysine	68-71	growth associated protein 43	Gallus gallus	28-34
17300219-5	2007	Furthermore, p300 acetylates MAML1 and evolutionarily conserved lysine residues in the MAML1 N-terminus are direct substrates for p300-mediated acetylation.	Lysine	64-70	mastermind like transcriptional coactivator 1	Homo sapiens	87-92
17573780-0	2007	RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.	Lysine	76-82	mortality factor 4 like 1	Homo sapiens	11-16
8063740-9	1994	These data suggest a novel mechanism whereby a plasmin-like serine protease may cleave Ann-II at Lys307-Arg308, exposing a new carboxyl-terminal lysine residue (Lys307) for binding and efficient activation of plasminogen.	Lysine	145-151	annexin A2	Homo sapiens	87-93
8063741-11	1994	Annexin-II-mediated enhancement of t-PA-dependent plasminogen activation was 90-95% inhibited by epsilon-aminocaproic acid or by pretreatment of Ann-II with carboxypeptidase B, indicating a carboxyl-terminal lysine-dependent interaction.	Lysine	208-214	annexin A2	Homo sapiens	0-10
7985780-2	1994	In this modification, a specific lysine residue of eIF-5A precursor protein is first converted to deoxyhypusine by an addition of a butylamino group derived from spermidine; the deoxyhypusine residue is then hydroxylated to form hypusine.	Lysine	33-39	eukaryotic translation initiation factor 5A	Homo sapiens	51-57
17433363-7	2007	To determine if these are key specificity determining residues, we attempted to induce a tighter association between the E2 UbcH5b and E6AP by mutating the corresponding positions in UbcH5b to lysine residues.	Lysine	193-199	ubiquitin protein ligase E3A	Homo sapiens	135-139
8039140-9	1994	A p53 gene mutation was also found in 1 of 10 carcinomas examined; a G--&gt;T transversion was detected at the third letter of codon 130, with a substitution of asparagine for lysine.	Lysine	176-182	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	2-5
17513436-7	2007	Thus, LOX can be a proxy for mitochondrial Lys uptake.	Lysine	43-46	lysyl oxidase	Rattus norvegicus	6-9
17513436-9	2007	In both the rat and piglet, after adapting to the high protein diet, the activity of LKR is 400-500 times that of LOX, suggesting that Lys uptake by a transporter(s) is rate limiting.	Lysine	135-138	lysyl oxidase	Rattus norvegicus	114-117
8041731-6	1994	These data suggest not only that Asp-813 is critical to the catalytic activity of the EGFR but also that differences may exist in the signaling properties of kinase-negative Lys-721 and kinase-negative Asp-813 EGFR mutants.	Lysine	174-177	epidermal growth factor receptor	Cricetulus griseus	86-90
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	ubiquitin interaction motif containing 1	Homo sapiens	0-5
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	BRCA1 DNA repair associated	Homo sapiens	39-44
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	BRCA1 associated RING domain 1	Homo sapiens	45-50
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Lysine	108-111	fibronectin 1	Mus musculus	336-347
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	BRCA1 associated RING domain 1	Homo sapiens	52-90
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	140-146
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	175-181	mediator of DNA damage checkpoint 1	Homo sapiens	150-154
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	ubiquitin interaction motif containing 1	Homo sapiens	0-5
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	BRCA1 DNA repair associated	Homo sapiens	39-44
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	BRCA1 associated RING domain 1	Homo sapiens	45-50
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	BRCA1 associated RING domain 1	Homo sapiens	52-90
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	140-146
8206999-9	1994	This revealed that CaM residues Thr-110, Leu-112, and Lys-115 were critical for full smMLCK activation and could not be substituted by the corresponding cTnC residue (Gln, Thr, and Thr, respectively).	Lysine	54-57	myosin light chain kinase	Homo sapiens	85-91
17525341-4	2007	RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs.	Lysine	190-196	mediator of DNA damage checkpoint 1	Homo sapiens	150-154
8005357-2	1994	Site directed mutations were constructed in the yeast iso-1-cytochrome c gene adjacent to the lysine 77 (methylation site) codon.	Lysine	94-100	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	54-59
17501908-4	2007	Overexpression of xLSD1 in A6 cells, a Xenopus laevis cell line, resulted in the decrease of methylation status of lysine residues of histone H3, indicating that the protein of cloned xLSD1 was functionally active.	Lysine	115-121	lysine (K)-specific demethylase 1A S homeolog	Xenopus laevis	18-23
17501908-4	2007	Overexpression of xLSD1 in A6 cells, a Xenopus laevis cell line, resulted in the decrease of methylation status of lysine residues of histone H3, indicating that the protein of cloned xLSD1 was functionally active.	Lysine	115-121	lysine (K)-specific demethylase 1A S homeolog	Xenopus laevis	184-189
17545071-4	2007	RESULTS: In CDS of the new cloned sequence, the 658 base A in the AF172993 sequence was replaced by C, and the corresponding genetic code was also converted from AAG to CAG, leading to the alteration of the amino acid Gln to Lys.	Lysine	225-228	N-methylpurine DNA glycosylase	Homo sapiens	162-165
8185828-5	1994	cDNA polymerase chain reaction-SSCP analysis and direct sequencing demonstrated a G--&gt;T transversion at the third position of p53 codon 130, with the resultant substitution of asparagine for lysine, in one of the 10 carcinomas induced by 100 ppm of PhIP for which freshly frozen samples were available.	Lysine	194-200	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	129-132
7509372-0	1994	Amino acid residues 226-240 of tau, which encompass the first Lys-Ser-Pro site of tau, are partially phosphorylated in Alzheimer paired helical filament-tau.	Lysine	62-66	microtubule associated protein tau	Homo sapiens	31-34
17392790-4	2007	The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity.	Lysine	131-134	DExD/H-box helicase 58	Homo sapiens	82-87
17392790-4	2007	The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity.	Lysine	131-134	DExD/H-box helicase 58	Homo sapiens	189-194
17392790-4	2007	The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity.	Lysine	131-134	DExD/H-box helicase 58	Homo sapiens	189-194
17392790-5	2007	The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction.	Lysine	4-7	DExD/H-box helicase 58	Homo sapiens	23-28
17392790-5	2007	The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction.	Lysine	4-7	DExD/H-box helicase 58	Homo sapiens	134-139
7509372-0	1994	Amino acid residues 226-240 of tau, which encompass the first Lys-Ser-Pro site of tau, are partially phosphorylated in Alzheimer paired helical filament-tau.	Lysine	62-66	microtubule associated protein tau	Homo sapiens	82-85
17392790-7	2007	Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity.	Lysine	65-68	DExD/H-box helicase 58	Homo sapiens	97-102
17392790-7	2007	Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity.	Lysine	65-68	DExD/H-box helicase 58	Homo sapiens	139-144
7509372-0	1994	Amino acid residues 226-240 of tau, which encompass the first Lys-Ser-Pro site of tau, are partially phosphorylated in Alzheimer paired helical filament-tau.	Lysine	62-66	microtubule associated protein tau	Homo sapiens	129-156
8069491-2	1994	The predicted ER10 and ERD14 polypeptides have a compositional bias towards Glu (19.62% and 21.08%, respectively) and Lys (16.15% and 18.38%, respectively) and both lack Trp and Cys residues.	Lysine	118-121	Dehydrin family protein	Arabidopsis thaliana	14-18
17307730-7	2007	Nampt overexpression also reduced the fraction of p53 that was acetylated on lysine 382, a target of SIRT1, suppressed an age-related increase in p53 expression, and increased the rate of p53 degradation.	Lysine	77-83	sirtuin 1	Homo sapiens	101-106
8116235-4	1994	Domain-swapping and site-directed mutagenesis experiments indicated that codon 9 of the core protein coding sequence played a crucial role on the synthesis of the core protein: a lysine codon at this position led to the synthesis of P16 and an arginine codon at this position led to the synthesis of P21.	Lysine	179-185	H3 histone pseudogene 16	Homo sapiens	300-303
17314980-7	2007	In one pathway defined here, we show that Rtt109 is the founding member of a novel class of histone acetyltransferases responsible for Asf1-dependent acetylation of histone H3 on lysine 56.	Lysine	179-185	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	42-48
17314980-7	2007	In one pathway defined here, we show that Rtt109 is the founding member of a novel class of histone acetyltransferases responsible for Asf1-dependent acetylation of histone H3 on lysine 56.	Lysine	179-185	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	135-139
17371260-7	2007	Acetylation of NF-kappaB [RelA (p65)] at Lys(310) enhances its transcriptional activity, which is inhibited by SIRT1 deacetylase, type III HDAC (histone deacetylase).	Lysine	41-44	sirtuin 1	Homo sapiens	111-116
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Lysine	50-53	serpin family C member 1	Homo sapiens	220-232
17371260-7	2007	Acetylation of NF-kappaB [RelA (p65)] at Lys(310) enhances its transcriptional activity, which is inhibited by SIRT1 deacetylase, type III HDAC (histone deacetylase).	Lysine	41-44	histone deacetylase 9	Homo sapiens	139-143
17371260-7	2007	Acetylation of NF-kappaB [RelA (p65)] at Lys(310) enhances its transcriptional activity, which is inhibited by SIRT1 deacetylase, type III HDAC (histone deacetylase).	Lysine	41-44	histone deacetylase 9	Homo sapiens	145-164
8286349-2	1994	In the present study three forms of human annexin I truncated in the amino terminus at residue Trp-12, Lys-26, or Lys-29 exhibit dramatic differences in their sensitivities to calcium in a chromaffin granule aggregation assay, while the [Ca2+](1/2)max values for binding of the truncated proteins to granule membranes are similar.	Lysine	103-106	annexin A1	Bos taurus	42-51
17374714-3	2007	Recent studies in budding yeast document a histone modification pathway associated with polII transcription, whereby ubiquitylation of histone H2B leads to methylation of histone H3 on specific lysine residues.	Lysine	194-200	histone H2B	Saccharomyces cerevisiae S288C	135-146
8286349-2	1994	In the present study three forms of human annexin I truncated in the amino terminus at residue Trp-12, Lys-26, or Lys-29 exhibit dramatic differences in their sensitivities to calcium in a chromaffin granule aggregation assay, while the [Ca2+](1/2)max values for binding of the truncated proteins to granule membranes are similar.	Lysine	114-117	annexin A1	Bos taurus	42-51
7903302-11	1993	The Arg-Lys sequence at positions 25-31, which resembles the binding site of apolipoprotein E, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor with high efficiency.	Lysine	8-11	lactotransferrin	Rattus norvegicus	136-147
17272500-6	2007	Quantitative polymerase chain reaction analysis of precipitated DNA unravels biphasic heterochromatin assembly on OCT4 and NANOG, involving H3 lysine (K)9 and K27 methylation followed by H3K9 deacetylation and additional H3K27 trimethylation.	Lysine	143-149	Nanog homeobox	Homo sapiens	123-128
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	8-14	keratin 36	Homo sapiens	123-126
17548299-1	2007	Histone lysine methylation plays a key role in epigenetic regulation.There are five lysines within histone H3(K4, K9, K27, K36, K79).	Lysine	84-91	keratin 36	Homo sapiens	123-126
17392473-3	2007	We report here that HDAC inhibitors, including trichostatin A (TSA), increase vesicular transport of brain-derived neurotrophic factor (BDNF) by inhibiting HDAC6, thereby increasing acetylation at lysine 40 of alpha-tubulin.	Lysine	197-203	brain derived neurotrophic factor	Homo sapiens	101-134
8268175-1	1993	The methyltransferase that catalyzes the trimethylation of lysine 115 in calmodulin has been purified from sheep brain.	Lysine	59-65	calmodulin	Ovis aries	73-83
17392473-3	2007	We report here that HDAC inhibitors, including trichostatin A (TSA), increase vesicular transport of brain-derived neurotrophic factor (BDNF) by inhibiting HDAC6, thereby increasing acetylation at lysine 40 of alpha-tubulin.	Lysine	197-203	brain derived neurotrophic factor	Homo sapiens	136-140
8224877-1	1993	The C-terminal region of the human neurofilament heavy subunit (NEFH) contains a unique functional domain consisting of 43 repeat motifs of the amino acids (aa) Lys-Ser-Pro (KSP) with either 3- or 5-aa spacers in between.	Lysine	161-164	neurofilament heavy chain	Homo sapiens	35-62
8224877-1	1993	The C-terminal region of the human neurofilament heavy subunit (NEFH) contains a unique functional domain consisting of 43 repeat motifs of the amino acids (aa) Lys-Ser-Pro (KSP) with either 3- or 5-aa spacers in between.	Lysine	161-164	neurofilament heavy chain	Homo sapiens	64-68
17375198-3	2007	MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val(5) and Lys(79)-Arg(80).	Lysine	67-70	matrix metallopeptidase 8	Mus musculus	0-5
8232202-0	1993	Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37 degrees C. Deletion of the SLT2 gene of Saccharomyces cerevisiae, which codes for a homologue of MAP (mitogen-activated) protein kinases, causes an autolytic lethal phenotype in cells grown at 37 degrees C. The gene encodes domains characteristic of protein kinases, which include a lysine (at position 54) that lies 19 residues from a glycine-rich cluster, considered to be the putative ATP binding site.	Lysine	379-385	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	43-47
17310145-5	2007	We demonstrate by expressing recombinant proteins in Escherichia coli that Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2.	Lysine	139-142	ubiquitin conjugating enzyme E2 G2	Homo sapiens	75-81
17310145-5	2007	We demonstrate by expressing recombinant proteins in Escherichia coli that Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2.	Lysine	139-142	autocrine motility factor receptor	Homo sapiens	82-86
17310145-5	2007	We demonstrate by expressing recombinant proteins in Escherichia coli that Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2.	Lysine	139-142	ubiquitin conjugating enzyme E2 G2	Homo sapiens	199-205
17310145-7	2007	Intriguingly, polyubiquitination of a substrate can be achieved by transferring preassembled ubiquitin chains from Ube2g2 to a lysine residue in a substrate.	Lysine	127-133	ubiquitin conjugating enzyme E2 G2	Homo sapiens	115-121
8373816-0	1993	Change of substrate specificity by chemical modification of lysine residues of porcine pancreatic alpha-amylase.	Lysine	60-66	amylase alpha 2A	Homo sapiens	87-111
17189688-2	2007	Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B.	Lysine	36-42	carboxypeptidase B1	Homo sapiens	170-188
8373816-1	1993	Lysine residues of porcine pancreatic alpha-amylase (PPA) were modified with trinitrobenzenesulfonate (TNBS).	Lysine	0-6	amylase alpha 2A	Homo sapiens	27-51
8347689-4	1993	Sequence and haplotype analysis revealed that D had two different mutant LDL receptor alleles: FH Durban-1 is a point mutation [asp69(GAT) to tyr(TAT)] in ligand-binding repeat 2 and FH Durban-2 is a point mutation [glu119(GAG) to lys(AAG)] in ligand-binding repeat three of the LDL receptor.	Lysine	26-29	low density lipoprotein receptor	Homo sapiens	73-85
17132685-5	2007	Alpha4, alpha5, and beta3 subunits all have a homologous glutamate in M2 that contributes to high Ca2+ permeability, whereas beta2 has a lysine at this position.	Lysine	137-143	immunoglobulin binding protein 1	Homo sapiens	0-6
8347689-4	1993	Sequence and haplotype analysis revealed that D had two different mutant LDL receptor alleles: FH Durban-1 is a point mutation [asp69(GAT) to tyr(TAT)] in ligand-binding repeat 2 and FH Durban-2 is a point mutation [glu119(GAG) to lys(AAG)] in ligand-binding repeat three of the LDL receptor.	Lysine	26-29	low density lipoprotein receptor	Homo sapiens	95-97
17182844-7	2007	Depletion of Np95 also causes a hyperacetylation of lysines 8, 12, and 16 of heterochromatin histone H4 and an increase of pericentromeric major satellite transcription, whose RNAs are key players for heterochromatin formation.	Lysine	52-59	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	13-17
8347689-4	1993	Sequence and haplotype analysis revealed that D had two different mutant LDL receptor alleles: FH Durban-1 is a point mutation [asp69(GAT) to tyr(TAT)] in ligand-binding repeat 2 and FH Durban-2 is a point mutation [glu119(GAG) to lys(AAG)] in ligand-binding repeat three of the LDL receptor.	Lysine	26-29	low density lipoprotein receptor	Homo sapiens	279-291
8346241-7	1993	To determine which lysine(s) are acylated, a series of synthetic peptides containing all lysines found in the IL-1 alpha N-terminal propiece were used in an in vitro myristoylation assay containing peptide, myristoyl-CoA, and monocyte lysate as enzyme source.	Lysine	89-96	interleukin 1 alpha	Homo sapiens	110-120
8368516-4	1993	One substrate, Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys-(Nma)-NH2, had favorable solubility characteristics, was &gt; 98% quenched, and produced a single cleavage product, Dnp-Pro-Cha-Gly, with a high fluorescence yield with both interstitial collagenase and 92-kDa gelatinase.	Lysine	47-50	matrix metallopeptidase 1	Homo sapiens	225-249
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	163-166	carboxypeptidase N subunit 1	Homo sapiens	129-133
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	163-166	carboxypeptidase N subunit 1	Homo sapiens	129-132
8509388-7	1993	The hexapeptide smMLCK-(797-802), Arg-Arg-Lys-Trp800-Gln-Lys, protected with a similar potency (PC0.5 = 73 +/- 14 nM).	Lysine	42-45	myosin light chain kinase	Homo sapiens	16-22
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	249-252	carboxypeptidase N subunit 1	Homo sapiens	129-133
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Lysine	249-252	carboxypeptidase N subunit 1	Homo sapiens	129-132
17135271-5	2007	Here we show that an intact RING domain of TRAF6 in conjunction with the E2 enzyme Ubc13/Uev1A is necessary for Lys-63-linked auto-ubiquitination of TRAF6 and for its ability to activate IKK and NF-kappaB.	Lysine	112-115	ubiquitin-conjugating enzyme E2N	Mus musculus	83-88
8509388-7	1993	The hexapeptide smMLCK-(797-802), Arg-Arg-Lys-Trp800-Gln-Lys, protected with a similar potency (PC0.5 = 73 +/- 14 nM).	Lysine	57-60	myosin light chain kinase	Homo sapiens	16-22
8348591-6	1993	Selective carbamoylation of tau with KCNO resulted in an irreversible modification of lysine residues on tau protein.	Lysine	86-92	microtubule associated protein tau	Homo sapiens	28-31
8348591-6	1993	Selective carbamoylation of tau with KCNO resulted in an irreversible modification of lysine residues on tau protein.	Lysine	86-92	microtubule associated protein tau	Homo sapiens	105-108
8468556-2	1993	The mutations were made by site-directed mutagenesis to alter basic amino acids (lysine or arginine) in the surface glycoprotein gp70.	Lysine	81-87	embigin	Mus musculus	129-133
17233604-3	2007	We observed that human MCF7 breast cancer cells that overexpress IGF1R efficiently internalized fluorescein-chelator-PNA-D(Cys-Ser-Lys-Cys) to the cytoplasm, but not with D(Cys-Ala-Ala-Cys).	Lysine	131-134	insulin like growth factor 1 receptor	Homo sapiens	65-70
17259403-5	2007	As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes.	Lysine	38-44	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	57-63
8424781-2	1993	H-189 [Pro-His-Pro-Phe-His-Sta-(statyl)-Val-Ile-His-Lys] is an analogue of human angiotensinogen.	Lysine	52-55	GCY	Homo sapiens	27-30
17259403-8	2007	We conclude that the lysine variant in KCNJ11 E23K leads to diminished insulin secretion in individuals with IGT.	Lysine	21-27	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	39-45
17182849-7	2007	This PPAY motif interacts with the WW domains of the ubiquitin ligase Rsp5, and mutations in either the WW or, surprisingly, the HECT domains of Rsp5 negatively impacted MVB targeting of lysine-minus Sna3.	Lysine	187-193	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	70-74
17182849-7	2007	This PPAY motif interacts with the WW domains of the ubiquitin ligase Rsp5, and mutations in either the WW or, surprisingly, the HECT domains of Rsp5 negatively impacted MVB targeting of lysine-minus Sna3.	Lysine	187-193	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	145-149
7678194-5	1993	The cross-linking of Lys residues in the heavy chain-light chain connecting strand to alpha 2M explains earlier findings that a substantial portion of the heavy chain is cross-linked to alpha 2M [Pizzo et al.	Lysine	21-24	alpha-2-macroglobulin	Homo sapiens	86-94
17107956-2	2007	We have found that budding yeast lacking Asf1 has greatly reduced levels of histone H3 acetylated at lysine 9.	Lysine	101-107	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	41-45
17107956-4	2007	Accordingly, we found that the vast majority of H3 Lys-9 acetylation peaked in S-phase, and this S-phase peak of H3 lysine 9 acetylation was absent in yeast lacking Asf1.	Lysine	116-122	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	165-169
17107956-7	2007	Strikingly, overexpression of Asf1 leads to greatly increased levels of H3 on acetylation on lysine 56 and Gcn5-dependent acetylation on lysine 9.	Lysine	93-99	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	30-34
7678194-5	1993	The cross-linking of Lys residues in the heavy chain-light chain connecting strand to alpha 2M explains earlier findings that a substantial portion of the heavy chain is cross-linked to alpha 2M [Pizzo et al.	Lysine	21-24	alpha-2-macroglobulin	Homo sapiens	186-194
17107956-7	2007	Strikingly, overexpression of Asf1 leads to greatly increased levels of H3 on acetylation on lysine 56 and Gcn5-dependent acetylation on lysine 9.	Lysine	137-143	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	30-34
17107956-8	2007	Analysis of a panel of Asf1 mutations that modulate the ability of Asf1 to bind to histones H3/H4 demonstrates that the histone binding activity of Asf1 is required for the acetylation of Lys-9 and Lys-56 on newly synthesized H3.	Lysine	188-191	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	23-27
1463470-2	1992	Escherichia coli dihydrodipicolinate synthase (DHDPS) (EC 4.2.1.52), the first enzyme unique to lysine biosynthesis, catalyses the condensation of pyruvate and aspartate beta-semialdehyde (ASA) by a ping-pong mechanism.	Lysine	96-102	dihydrodipicolinate synthase	Escherichia coli	17-45
17107956-8	2007	Analysis of a panel of Asf1 mutations that modulate the ability of Asf1 to bind to histones H3/H4 demonstrates that the histone binding activity of Asf1 is required for the acetylation of Lys-9 and Lys-56 on newly synthesized H3.	Lysine	188-191	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	67-71
17107956-8	2007	Analysis of a panel of Asf1 mutations that modulate the ability of Asf1 to bind to histones H3/H4 demonstrates that the histone binding activity of Asf1 is required for the acetylation of Lys-9 and Lys-56 on newly synthesized H3.	Lysine	188-191	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	67-71
1463470-2	1992	Escherichia coli dihydrodipicolinate synthase (DHDPS) (EC 4.2.1.52), the first enzyme unique to lysine biosynthesis, catalyses the condensation of pyruvate and aspartate beta-semialdehyde (ASA) by a ping-pong mechanism.	Lysine	96-102	dihydrodipicolinate synthase	Escherichia coli	47-52
1463470-6	1992	DHDPS is 50% inhibited by 1.0 mM-L-lysine, 1.2 mM-sodium dipicolinate or 4.6 mM-S-2-aminoethyl-L-cysteine.	Lysine	32-41	dihydrodipicolinate synthase	Escherichia coli	0-5
16948129-5	2007	The largest solubility increases were of 4.2-, 4.8-, and 6.2-folds produced by the addition, at the C terminus, of five lysine (BPTI-22-C5K), five and six arginine residues (BPTI-22-C5R and BPTI-22-C6R), respectively.	Lysine	120-126	spleen trypsin inhibitor I	Bos taurus	174-178
1286938-5	1992	A CF-FAB analysis of carboxypeptidase digestions allowed observation of peptide cleavage down to an ion corresponding to lysine, Fmoc, and the corresponding protecting group(s).	Lysine	121-127	FA complementation group B	Homo sapiens	5-8
16948129-5	2007	The largest solubility increases were of 4.2-, 4.8-, and 6.2-folds produced by the addition, at the C terminus, of five lysine (BPTI-22-C5K), five and six arginine residues (BPTI-22-C5R and BPTI-22-C6R), respectively.	Lysine	120-126	spleen trypsin inhibitor I	Bos taurus	174-178
17605300-4	2007	Extraordinarily high levels of trimethyl histone H3 lysine 4 (H3K4) were found primarily in the first intron of the Keratin 8 gene stretching from 400 to 2000 bp downstream from the promoter in all breast cancer cells lines but not in MCF-10A cells.	Lysine	52-58	keratin 8	Homo sapiens	116-125
1458828-8	1992	Two proteolytic peptides, D7 and D9 derived from canine protein 4.1, both corresponding to the human sequence Thr492-...-Asn (or Asp)502-...-Lys505 showed the same sequence, Thr-Gln-Thr-...-Lys, except that the 11th residue equivalent to the 502nd amino acid was Asn in D7 while it was Asp in D9, indicating that deamidation occurs at the same position in canine protein 4.1 as in humans.	Lysine	141-144	erythrocyte membrane protein band 4.1	Canis lupus familiaris	56-67
17101786-6	2007	However, the addition of recombinant SU(VAR) protein, such as ACF1 or SU(VAR)3-9, facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9).	Lysine	133-139	bromodomain adjacent to zinc finger domain 1A	Homo sapiens	62-66
17101795-3	2007	Here, we found that myocardin"s activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation.	Lysine	95-101	myocardin	Homo sapiens	20-29
17392337-2	2007	For instance, tri-methylation of lysine 4 on histone H3 (H3K4) strongly correlates with transcriptional activity and is regulated by the Bur1/2 kinase complex.	Lysine	33-39	cyclin-dependent serine/threonine protein kinase SGV1	Saccharomyces cerevisiae S288C	137-143
1425427-0	1992	Posttranslational processing of proenkephalin in AtT-20 cells: evidence for cleavage at a Lys-Lys site.	Lysine	90-93	proenkephalin	Rattus norvegicus	32-45
1425427-0	1992	Posttranslational processing of proenkephalin in AtT-20 cells: evidence for cleavage at a Lys-Lys site.	Lysine	94-97	proenkephalin	Rattus norvegicus	32-45
1425427-6	1992	Radiosequencing results verified the efficient cleavage of a Lys-Lys site within proenkephalin that resulted in the production of the 5.3-kDa peptide.	Lysine	61-64	proenkephalin	Rattus norvegicus	81-94
1425427-6	1992	Radiosequencing results verified the efficient cleavage of a Lys-Lys site within proenkephalin that resulted in the production of the 5.3-kDa peptide.	Lysine	65-68	proenkephalin	Rattus norvegicus	81-94
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	147-150	proenkephalin	Rattus norvegicus	50-63
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	147-150	proenkephalin	Rattus norvegicus	163-176
17097055-3	2006	We report that mouse Sox2 is modified by SUMO at lysine 247.	Lysine	49-55	SRY (sex determining region Y)-box 2	Mus musculus	21-25
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	151-154	proenkephalin	Rattus norvegicus	50-63
17097055-6	2006	Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer.	Lysine	39-45	SRY (sex determining region Y)-box 2	Mus musculus	27-31
1425427-8	1992	An important difference between the processing of proenkephalin and the ACTH/endorphin precursor (POMC) in AtT-20 cells is efficient cleavage of a Lys-Lys site in proenkephalin and not in POMC.	Lysine	151-154	proenkephalin	Rattus norvegicus	163-176
1425427-9	1992	The ability of AT/PE to process proenkephalin in a natural manner makes it a suitable model system to investigate elements involved in the processing of proenkephalin at Lys-Lys sites.	Lysine	170-173	proenkephalin	Rattus norvegicus	153-166
1425427-9	1992	The ability of AT/PE to process proenkephalin in a natural manner makes it a suitable model system to investigate elements involved in the processing of proenkephalin at Lys-Lys sites.	Lysine	174-177	proenkephalin	Rattus norvegicus	153-166
1328239-2	1992	Lys-356 has been implicated as a critical residue for binding the C-6 phospho group of fructose 2,6-bisphosphate to the fructose-2,6-bisphosphatase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (Li, L., Lin, K., Correia, J., and Pilkis, S. J.	Lysine	0-3	complement C6	Rattus norvegicus	66-69
17049505-8	2006	Also l-lysine caused a decrease in the levels MMP-2 and MMP-9 as well as their enzymatic activity.	Lysine	5-13	matrix metallopeptidase 9	Homo sapiens	56-61
17101444-3	2006	BHC110, the first known histone lysine demethylase, removes methyl groups from methylated histone H3 lysine 4 and has been found in many multi-protein complexes.	Lysine	32-38	lysine demethylase 1A	Homo sapiens	0-6
1328239-13	1992	The results demonstrate that in addition to Lys-356, Arg-352 is another critical residue in fructose-2,6-bisphosphatase for binding the C-6 phospho group of fructose 2,6-bisphosphate and that Arg-360 binds the C-2 phospho group of fructose 2,6-bisphosphate in the phosphoenzyme.fructose 2,6-bisphosphate complex.	Lysine	44-47	complement C6	Rattus norvegicus	136-139
1383319-10	1992	This implies that cell modification with lysine-reactive TNP reagents results in immunodominant, highly repetitive TNP epitopes, which may explain the strong antigenicity and the allergenic properties of TNP, as well as the restricted TCR repertoire directed against this hapten.	Lysine	41-47	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	235-238
17012228-9	2006	Site-directed mutagenesis studies showed that Lys-386 of p53, the SUMO-1 modification site, is also the modification site for SUMO-2/3.	Lysine	46-49	small ubiquitin like modifier 3	Homo sapiens	126-134
16857984-5	2006	Mutation of this critical lysine (ie, Stat1(K703R)) yielded a protein that, when expressed in Stat1(-/-) mouse embryonic fibroblasts (MEFs), exhibited enhanced DNA binding and nuclear retention.	Lysine	26-32	signal transducer and activator of transcription 1	Mus musculus	38-43
1530638-3	1992	The binding mode of n-C12PC to the PLA2 was clearly indicated, where the dodecyl chain was stably held by the hydrophobic contacts with the N-terminal region of PLA2 (Leu-2, Phe-5, and Ile-9), and the choline moiety was contacted with the hydrophobic space created by the side chains of Lys-53 and 56.	Lysine	287-290	LOC104974671	Bos taurus	35-39
16857984-5	2006	Mutation of this critical lysine (ie, Stat1(K703R)) yielded a protein that, when expressed in Stat1(-/-) mouse embryonic fibroblasts (MEFs), exhibited enhanced DNA binding and nuclear retention.	Lysine	26-32	signal transducer and activator of transcription 1	Mus musculus	94-99
17059404-2	2006	Map-based cloning showed that the mutated gene (At1g71100) encodes a ribose 5-phosphate isomerase (RPI) and that the rsw10 mutation replaces a conserved glutamic acid residue with lysine.	Lysine	180-186	Ribose 5-phosphate isomerase, type A protein	Arabidopsis thaliana	117-122
1530638-3	1992	The binding mode of n-C12PC to the PLA2 was clearly indicated, where the dodecyl chain was stably held by the hydrophobic contacts with the N-terminal region of PLA2 (Leu-2, Phe-5, and Ile-9), and the choline moiety was contacted with the hydrophobic space created by the side chains of Lys-53 and 56.	Lysine	287-290	LOC104974671	Bos taurus	161-165
1512231-6	1992	Bovine rhodopsin in disc membranes was digested with thermolysin to generate the C-terminal fragment (241-327), which was subsequently cleaved with cyanogen bromide to generate the peptide Val-Thr-Thr-Leu-Cys-Cys-Gly-Lys-Asn-Pro (318-327).	Lysine	217-220	rhodopsin	Bos taurus	7-16
16916794-3	2006	Substitution of specific lysine residues in Dpb3p, highlighted by homology modeling of Dpb3p-Dpb4p based on the structure of the histone H2A-H2B dimer, indicated that they play roles in binding of dsDNA by Dpb3p-Dpb4p, in a manner similar to the histone-DNA interaction.	Lysine	25-31	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	44-49
16916794-3	2006	Substitution of specific lysine residues in Dpb3p, highlighted by homology modeling of Dpb3p-Dpb4p based on the structure of the histone H2A-H2B dimer, indicated that they play roles in binding of dsDNA by Dpb3p-Dpb4p, in a manner similar to the histone-DNA interaction.	Lysine	25-31	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	87-92
16916794-3	2006	Substitution of specific lysine residues in Dpb3p, highlighted by homology modeling of Dpb3p-Dpb4p based on the structure of the histone H2A-H2B dimer, indicated that they play roles in binding of dsDNA by Dpb3p-Dpb4p, in a manner similar to the histone-DNA interaction.	Lysine	25-31	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	87-92
16916794-4	2006	The lysine-substituted dpb3 mutants also displayed reduced telomeric silencing, whose degree paralleled that of the dsDNA-binding activity of Pol epsilon in the corresponding dpb3 mutants.	Lysine	4-10	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	23-27
16916794-4	2006	The lysine-substituted dpb3 mutants also displayed reduced telomeric silencing, whose degree paralleled that of the dsDNA-binding activity of Pol epsilon in the corresponding dpb3 mutants.	Lysine	4-10	DNA polymerase epsilon noncatalytic subunit	Saccharomyces cerevisiae S288C	175-179
1644829-8	1992	Lys at position 37, which is common to various aspartic proteinases and is thought to be important for stabilizing the activation segment, was absent at the corresponding position, as in human procathepsin E.	Lysine	0-3	cathepsin E	Cavia porcellus	193-207
1628641-8	1992	We have constructed derivatives of the KRS1 gene, encoding enzymes lacking 58 or 69 amino-terminal residues and, by site-directed mutagenesis, we have changed four or eight lysine residues from the amino-terminal segment of LysRS into glutamic acids.	Lysine	173-179	lysine--tRNA ligase KRS1	Saccharomyces cerevisiae S288C	39-43
17052455-0	2006	Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10.	Lysine	29-35	histone H2B	Saccharomyces cerevisiae S288C	0-11
1607649-3	1992	We previously reported that alterations in the H chain V regions can affect the binding of first component of C (C1q) and a major breakdown product of the third C component (C3b) when otherwise identical antibodies were bound to immobilized (Tyr, Glu)-Ala-Lys.	Lysine	256-259	complement C1q A chain	Homo sapiens	113-116
1377237-10	1992	Also, rHSA-sp containing an sp with a Lys to Thr substitution, which is known to reduce nuclear import markedly, was transported only poorly.	Lysine	38-41	CD24 molecule	Rattus norvegicus	6-10
16950240-8	2006	Histone deacetylation in NPC, demethylation of lysine 4 of histone H3 (H3K4), tri-methylation of H3K27, and CpG methylation in PMN are targeted for the Oct3/4 promoter within the region.	Lysine	47-53	POU domain, class 5, transcription factor 1	Mus musculus	152-158
16912044-3	2006	RXRalpha was modified by SUMO-1 in vivo as well as in vitro, and the Lys-108 residue within the IKPP sequence of RXRalpha AF-1 domain was identified as the major SUMO-1 acceptor site.	Lysine	69-72	retinoid X receptor alpha	Homo sapiens	113-121
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Lysine	35-38	retinoid X receptor alpha	Homo sapiens	118-126
1606966-1	1992	Tetrameric rods, protofilaments and assembled filaments of desmin, the intermediate filament protein of muscle, have been chemically cross-linked with the lysine specific cross-linkers EGS [ethylene glycol bis(succinimidylsuccinate), 1.61 nm span] and bis(sulfosuccinimidyl) suberate (1.14 nm span).	Lysine	155-161	desmin	Homo sapiens	59-65
16877758-5	2006	The lysine-less class I molecules could no longer be dislocated by US2 despite the fact that the interaction between the two proteins was maintained.	Lysine	4-10	usherin	Homo sapiens	67-70
1374217-2	1992	The authors investigated whether immunocytochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin) could be used to identify proliferative hepatocytes in frozen sections fixed in a mixture of periodate, lysine, and 2% paraformaldehyde.	Lysine	244-250	proliferating cell nuclear antigen	Homo sapiens	91-125
16909208-1	2006	Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde.	Lysine	56-62	lysyl oxidase	Homo sapiens	0-13
16909208-1	2006	Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde.	Lysine	56-62	lysyl oxidase	Homo sapiens	15-18
16909208-1	2006	Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde.	Lysine	83-89	lysyl oxidase	Homo sapiens	0-13
16909208-1	2006	Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of alpha-aminoadipic-delta-semialdehyde.	Lysine	83-89	lysyl oxidase	Homo sapiens	15-18
16909208-5	2006	In addition to elastin and collagen, LOX can oxidize lysine within a variety of cationic proteins, suggesting that its functions extend beyond its role in the stabilization of the extracellular matrix.	Lysine	53-59	lysyl oxidase	Homo sapiens	37-40
1374217-2	1992	The authors investigated whether immunocytochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin) could be used to identify proliferative hepatocytes in frozen sections fixed in a mixture of periodate, lysine, and 2% paraformaldehyde.	Lysine	244-250	proliferating cell nuclear antigen	Homo sapiens	127-138
17014440-7	2006	Substrate specificity of equine tryptase was investigated using arginine and lysine containing substrates.	Lysine	77-83	proto-oncogene tyrosine-protein kinase receptor Ret	Equus caballus	32-40
1567844-8	1992	This difference can be attributed to the presence of a long Lys side chain in the C-terminal finger of MBP-1 at position 40, instead of a short Ala or Ser side chain at the equivalent position in Zif-268.	Lysine	60-63	mannose binding lectin 2	Homo sapiens	103-108
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-113	cytochrome c, somatic	Equus caballus	39-51
17032747-4	2006	Most mutations introduced in this region reduced or abolished transcriptional activity of the Nurr1 LBD, but mutation at lysine (K577) resulted in a drastically increased activity.	Lysine	121-127	nuclear receptor subfamily 4 group A member 2	Homo sapiens	94-99
16951376-7	2006	We have identified three charged amino acids (arginine 480, lysine 481, and arginine 486) which are essential in the binding of alpha-actinins to the ICAM-1 cytoplasmic tail.	Lysine	60-66	intercellular adhesion molecule 1	Cricetulus griseus	150-156
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-113	cytochrome c, somatic	Equus caballus	73-85
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-113	cytochrome c, somatic	Equus caballus	73-85
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-112	cytochrome c, somatic	Equus caballus	39-51
16829529-7	2006	AtGRXcp expression can also suppress iron accumulation and partially rescue the lysine auxotrophy of yeast grx5 cells.	Lysine	80-86	CAX interacting protein 1	Arabidopsis thaliana	0-7
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-112	cytochrome c, somatic	Equus caballus	73-85
1313432-5	1992	Furthermore, the degradation of t-PA was not influenced by 10 mM 6-aminohexanoic acid, a lysine analogue.	Lysine	89-95	plasminogen activator, tissue type	Rattus norvegicus	32-36
1554354-0	1992	The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site.	Lysine	14-17	coagulation factor III, tissue factor	Homo sapiens	48-61
16917500-3	2006	In a Mnk1 crystal structure, the activation segment is repositioned via a Mnk-specific sequence insertion at the N-terminal lobe with the following consequences: (i) the peptide substrate binding site is deconstructed, (ii) the interlobal cleft is narrowed, (iii) an essential Lys-Glu pair is disrupted and (iv) the magnesium-binding loop is locked into an ATP-competitive conformation.	Lysine	277-280	MAPK interacting serine/threonine kinase 1	Homo sapiens	5-9
16917500-3	2006	In a Mnk1 crystal structure, the activation segment is repositioned via a Mnk-specific sequence insertion at the N-terminal lobe with the following consequences: (i) the peptide substrate binding site is deconstructed, (ii) the interlobal cleft is narrowed, (iii) an essential Lys-Glu pair is disrupted and (iv) the magnesium-binding loop is locked into an ATP-competitive conformation.	Lysine	277-280	ATPase copper transporting alpha	Homo sapiens	5-8
1794997-5	1991	These additional crosslinks proved to be stable in saline at 37 degrees C. Studies on bovine serum albumin attempted to get an insight into the mechanisms of lysine enhancement of glutaraldehyde crosslinking by treating sequentially albumin with glutaraldehyde and lysine and analysis of the products by gel filtration and SDS-PAGE.	Lysine	158-164	albumin	Bos taurus	93-106
1939226-0	1991	Lysine residues 165 and 166 are essential for the cofactor function of tissue factor.	Lysine	0-6	coagulation factor III, tissue factor	Homo sapiens	71-84
16733732-0	2006	Novel lysine biosynthetic gene sequences (LYS1 and LYS5) used as PCR targets for the detection of the pathogenic Candida yeast.	Lysine	6-12	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	42-46
1939226-2	1991	Two adjacent lysine residues (numbers 165 and 166) were identified in the extracytoplasmic domain of tissue factor that are crucial for function.	Lysine	13-19	coagulation factor III, tissue factor	Homo sapiens	101-114
1656067-2	1991	The deduced primary translation product of the CAEV env gene consists of a 60- to 80-amino-acid signal peptide followed by an amino-terminal surface protein (SU) and a carboxy-terminal transmembrane protein (TM) separated by an Arg-Lys-Lys-Arg cleavage site.	Lysine	232-235	envelope polyprotein;trans-regulatory splicing-like protein	Caprine arthritis encephalitis virus	52-55
16757475-3	2006	Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the presence of MCAF1.	Lysine	182-188	activating transcription factor 7 interacting protein	Homo sapiens	60-65
16757475-3	2006	Here we demonstrate that SUMOs directly interact with human MCAF1, which forms complexes with either the methyl-CpG-binding protein MBD1 or SETDB1, which trimethylates histone H3 at lysine 9 (H3-K9) in the presence of MCAF1.	Lysine	182-188	activating transcription factor 7 interacting protein	Homo sapiens	218-223
16760474-9	2006	Site-directed mutagenesis revealed that Arg-118, which corresponds to Lys-120 of variola virus complement regulator SPICE (a residue critical for its enhanced C3b cofactor activity), contributes significantly in enhancing this activity.	Lysine	70-73	complement C3	Homo sapiens	159-162
1656067-2	1991	The deduced primary translation product of the CAEV env gene consists of a 60- to 80-amino-acid signal peptide followed by an amino-terminal surface protein (SU) and a carboxy-terminal transmembrane protein (TM) separated by an Arg-Lys-Lys-Arg cleavage site.	Lysine	236-239	envelope polyprotein;trans-regulatory splicing-like protein	Caprine arthritis encephalitis virus	52-55
1753964-3	1991	H2B can be linked to DNA via its N-terminal tail and via several lysines contained within residues 24-34.	Lysine	65-72	H2B clustered histone 21	Homo sapiens	0-3
16878944-5	2006	This mutation also simplifies ET gating by removing Lys 79, which can serve as a ligand in the alkaline conformer of iso-1-Cytc.	Lysine	52-55	eukaryotic translation initiation factor 1	Homo sapiens	117-127
1714895-1	1991	The ubiquitin (Ub)-conjugating enzyme E2(25K) catalyzes the synthesis of multi-Ub chains in which successive Ub units are linked by an isopeptide bond involving the epsilon-amino group of Lys-48 of Ubn, and the COOH-terminal Gly residue of Ubn+1 (Chen, Z., and Pickart, C. M. (1990) J. Biol.	Lysine	188-191	ubiquitin conjugating enzyme E2 K	Bos taurus	38-44
16737973-7	2006	Further analysis of various RyR1 mutants containing successively smaller numbers of these mutations identified 2 amino acid residues (Gln(4020) and Lys(4021)) that, when mutated to their RyR3 counterparts (Leu(3873) and Gln(3874)), abolished 4-CmC activation of RyR1.	Lysine	148-151	ryanodine receptor 3	Homo sapiens	187-191
16687393-8	2006	Meanwhile, Lys-115 and conserved, ubiquitinatable Lys-121 are critical for Sir2alpha-mediated degradation.	Lysine	11-14	sirtuin 1	Homo sapiens	75-84
16687393-8	2006	Meanwhile, Lys-115 and conserved, ubiquitinatable Lys-121 are critical for Sir2alpha-mediated degradation.	Lysine	50-53	sirtuin 1	Homo sapiens	75-84
16687393-12	2006	We also propose that Sir2alpha is involved in deacetylation of H2A.z, which results in ubiquitination of Lys-115 and Lys-121 and its degradation via a ubiquitin/proteasome-dependent pathway.	Lysine	105-108	sirtuin 1	Homo sapiens	21-30
1903841-2	1991	One of its lysine residues is modified by spermidine to form hypusine, a posttranslational modification unique to eIF-5A.	Lysine	11-17	eukaryotic translation initiation factor 5A	Homo sapiens	114-120
16687393-12	2006	We also propose that Sir2alpha is involved in deacetylation of H2A.z, which results in ubiquitination of Lys-115 and Lys-121 and its degradation via a ubiquitin/proteasome-dependent pathway.	Lysine	117-120	sirtuin 1	Homo sapiens	21-30
16913849-8	2006	The results suggest that the lysine residue in the epitope is critical for recognition of Ki-67 antigen in FFPE tissue.	Lysine	29-35	antigen identified by monoclonal antibody Ki 67	Mus musculus	90-95
1903841-12	1991	The TIF51A gene was altered by site-directed mutagenesis at the site of hypusination by changing the Lys codon to that for Arg, thereby producing a stable protein that retains the positive charge but is not modified to the hypusine derivative.	Lysine	101-104	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	4-10
1680851-1	1991	The 1,646 cm-1 band in a resonance Raman spectrum obtained with excitation in the charge-transfer band of the complex of oxidized D-amino acid oxidase (DAO) with the oxidation product of D-lysine catalyzed by DAO shifted to 1,617 cm-1 upon 2-13C substitution of lysine.	Lysine	189-195	D-amino acid oxidase	Homo sapiens	130-150
16648821-7	2006	Indeed, acetylation on Lys 730 drives c-Abl accumulation in the cytoplasm and promotes differentiation.	Lysine	23-26	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	38-43
16648821-8	2006	Thus, Lys 730 acetylation is a novel post-translational modification of c-Abl and a novel mechanism for modulating its subcellular localization that contributes to myogenic differentiation.	Lysine	6-9	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	72-77
1680851-1	1991	The 1,646 cm-1 band in a resonance Raman spectrum obtained with excitation in the charge-transfer band of the complex of oxidized D-amino acid oxidase (DAO) with the oxidation product of D-lysine catalyzed by DAO shifted to 1,617 cm-1 upon 2-13C substitution of lysine.	Lysine	189-195	D-amino acid oxidase	Homo sapiens	152-155
1680851-1	1991	The 1,646 cm-1 band in a resonance Raman spectrum obtained with excitation in the charge-transfer band of the complex of oxidized D-amino acid oxidase (DAO) with the oxidation product of D-lysine catalyzed by DAO shifted to 1,617 cm-1 upon 2-13C substitution of lysine.	Lysine	189-195	D-amino acid oxidase	Homo sapiens	209-212
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Lysine	94-100	complement C5	Rattus norvegicus	3-7
16817852-6	2006	Instead, SGK-1 degradation required a lysine-less six-amino-acid (amino acids 19-24) hydrophobic motif (GMVAIL) within the N-terminal domain.	Lysine	38-44	serum/glucocorticoid regulated kinase 1	Homo sapiens	9-14
16817852-9	2006	Ubiquitin modification and degradation of SGK-1 were increasingly inhibited by the progressive mutation of six N-terminal lysine residues surrounding the GMVAIL motif.	Lysine	122-128	serum/glucocorticoid regulated kinase 1	Homo sapiens	42-47
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Lysine	94-100	complement C5	Rattus norvegicus	64-68
1996961-7	1991	of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC5a between histidine-67 and lysine-68 near the C-terminus of rC5a.	Lysine	94-100	complement C5	Rattus norvegicus	64-68
16775054-11	2006	1, increasing TID Lys from 1.10 to 1.50% increased ADG (quadratic; P &lt; 0.05) and improved G:F (linear; P &lt; 0.002).	Lysine	18-21	ADG	Sus scrofa	51-54
1671567-3	1991	Incubation of melittin with transglutaminase in the absence of DNC originated high molecular mass complexes indicative that the peptide lysine residue can act as an acyl acceptor.	Lysine	136-142	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	28-44
16775054-15	2006	Various methods of analyzing the growth response surface indicated that the optimal TID Lys concentration ranged from 1.28 to 1.32% for ADG (Exp.	Lysine	88-91	ADG	Sus scrofa	136-139
1904699-1	1991	The authors present here the published values of lysine in some biological fluids, plasma, urine, CSF, amniotic fluid, aqueous humor, sweat.	Lysine	49-55	colony stimulating factor 2	Homo sapiens	98-101
16813535-13	2006	RESULTS: The novel mutation introduces a premature stop codon in place of Lys-378 and thereby eliminates the entire p62 UBA domain; this and two additional natural mutations (P392L, E396X) increased NF-kappaB activation compared with wildtype p62.	Lysine	74-77	sequestosome 1	Homo sapiens	116-119
16813535-13	2006	RESULTS: The novel mutation introduces a premature stop codon in place of Lys-378 and thereby eliminates the entire p62 UBA domain; this and two additional natural mutations (P392L, E396X) increased NF-kappaB activation compared with wildtype p62.	Lysine	74-77	sequestosome 1	Homo sapiens	243-246
2046858-5	1991	Carboxypeptidase E activity is stimulated in vitro by cobalt ion and removes the Lys and Arg residues with equal facility.	Lysine	81-84	carboxypeptidase E	Homo sapiens	0-18
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
1945471-2	1991	Glutaric aciduria type I is an inherited metabolic disorder of organic acids due to a defect of glutaryl-CoA-dehydrogenase in the intermediate metabolic step of lysine and tryptophan degradation.	Lysine	161-167	glutaryl-CoA dehydrogenase	Homo sapiens	96-122
16600213-6	2006	Mutation of a conserved lysine in this region weakened Cdc20 binding and correspondingly reduced checkpoint function.	Lysine	24-30	cell division cycle 20	Homo sapiens	55-60
2174883-4	1990	Conjugates produced by the RAD6 protein were better proteolytic substrates than those formed by reticulocyte E2 unless ubiquitin molecules with altered lysines were used for conjugate synthesis.	Lysine	152-159	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	27-31
16713412-1	2006	The lysine residues of guinea pig P450 17alpha were acetylated by acetic anhydride in the absence and presence of NADPH cytochrome P450 reductase (CPR).	Lysine	4-10	NADPH--cytochrome P450 reductase	Cavia porcellus	114-145
16713412-1	2006	The lysine residues of guinea pig P450 17alpha were acetylated by acetic anhydride in the absence and presence of NADPH cytochrome P450 reductase (CPR).	Lysine	4-10	NADPH--cytochrome P450 reductase	Cavia porcellus	147-150
2174883-4	1990	Conjugates produced by the RAD6 protein were better proteolytic substrates than those formed by reticulocyte E2 unless ubiquitin molecules with altered lysines were used for conjugate synthesis.	Lysine	152-159	ubiquitin	Oryctolagus cuniculus	119-128
2268676-4	1990	This observation suggests a critical role for Lys-606 during catalysis by maize phosphoenolpyruvate carboxylase.	Lysine	46-49	MLO-like protein 4	Zea mays	80-111
16699007-10	2006	These findings support the role of LANA as a transcriptional repressor of lytic reactivation and provide evidence that lysine acetylation regulates LANA interactions with chromatin, Sp1, and ORF50 promoter DNA.	Lysine	119-125	ORF50	Human gammaherpesvirus 8	191-196
2079039-2	1990	A crude product of GHRP, a hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, synthesized by the solid phase methodology, was desalted and analyzed by CZE.	Lysine	81-84	ghrelin and obestatin prepropeptide	Homo sapiens	19-23
16622709-6	2006	dG9a catalyzes the transfer of methyl groups to full-length histone H3 and to N-terminal H3 peptides that contain lysine 9, suggesting that the major target for dG9a is K9H3.	Lysine	114-120	G9a	Drosophila melanogaster	0-4
16622709-6	2006	dG9a catalyzes the transfer of methyl groups to full-length histone H3 and to N-terminal H3 peptides that contain lysine 9, suggesting that the major target for dG9a is K9H3.	Lysine	114-120	G9a	Drosophila melanogaster	161-165
2211650-9	1990	Determination of the monovalent salt dependence of the association constant revealed that as many as 8 lysine-phosphate type ionic bonds are formed in the TFIIIA-DNA complex.	Lysine	103-109	general transcription factor 3A L homeolog	Xenopus laevis	155-161
16549060-0	2006	Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia.	Lysine	8-14	zinc finger and BTB domain containing 16	Homo sapiens	78-82
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Lysine	162-165	Sld2p	Saccharomyces cerevisiae S288C	4-8
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Lysine	171-174	Sld2p	Saccharomyces cerevisiae S288C	4-8
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Lysine	171-174	Sld2p	Saccharomyces cerevisiae S288C	4-8
2395872-4	1990	Sequence analysis of the isolated secretin precursor revealed a 71-amino acid residue polypeptide that contained the sequence of secretin N terminally, followed by a Gly-Lys-Arg sequence and a C-terminal extension of 41-amino acid residues.	Lysine	170-173	secretin	Sus scrofa	34-42
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
2171636-6	1990	Both Lys residues of D-2 were quantitatively recovered upon sequencing after digestion with endoproteinase Glu-C.	Lysine	5-8	solute carrier family 3 member 1	Rattus norvegicus	21-24
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Lysine	55-58	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	65-69
16618800-6	2006	Characterization of dSfmbt protein shows that its MBT repeats have unique discriminatory binding activity for methylated lysine residues in histones H3 and H4; the MBT repeats bind mono- and di-methylated H3-K9 and H4-K20 but fail to interact with these residues if they are unmodified or tri-methylated.	Lysine	121-127	Scm-related gene containing four mbt domains	Drosophila melanogaster	20-26
2187871-8	1990	Factor eIF-4D is the only known mammalian protein that undergoes a unique post-translational modification of Lys-50 to the amino acid hypusine, and interestingly the same lysine is also present in the ANB1 gene product.	Lysine	109-112	eukaryotic translation initiation factor 5A	Homo sapiens	7-13
16612003-6	2006	In addition, while the acetylation of all four histone H4 NH(2)-terminal tail domain lysine residues is increased following DSB formation, only the acetylation of H4 lysine 12, the primary target of Hat1p activity, is dependent on the presence of Hat1p.	Lysine	85-91	H4 clustered histone 9	Homo sapiens	47-57
2187871-8	1990	Factor eIF-4D is the only known mammalian protein that undergoes a unique post-translational modification of Lys-50 to the amino acid hypusine, and interestingly the same lysine is also present in the ANB1 gene product.	Lysine	171-177	eukaryotic translation initiation factor 5A	Homo sapiens	7-13
2111847-4	1990	In this report, the published sequences of the mitochondrial genes for COI and ND1 in a platyhelminth (Fasciola hepatica) are examined and it is concluded that AAA may be a codon for asparagine instead of lysine, whereas AAG is the sole codon for lysine in this species.	Lysine	247-253	ND1	Fasciola hepatica	79-82
16720236-12	2006	CONCLUSION: When DTPA was conjugated to the epsilon NH2 group of the Lys(154) residue, MHC binding of the peptide was preserved and could still be recognized by cytotoxic T cells.	Lysine	69-72	major histocompatibility complex, class I, C	Homo sapiens	87-90
1691502-8	1990	These results indicated that disuccinimidyl suberate cross-linked the NH2 group of EGF residue Asn-1 to the human EGF receptor residue Lys-336.	Lysine	135-138	epidermal growth factor	Homo sapiens	83-86
16617102-4	2006	Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence.	Lysine	54-60	metastasis associated 1	Homo sapiens	32-36
16567619-0	2006	NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.	Lysine	41-48	small ubiquitin like modifier 2	Homo sapiens	23-29
1691502-8	1990	These results indicated that disuccinimidyl suberate cross-linked the NH2 group of EGF residue Asn-1 to the human EGF receptor residue Lys-336.	Lysine	135-138	epidermal growth factor	Homo sapiens	114-117
2154668-4	1990	When the C-terminal lysine of ODN is blocked with an NH2 group, the ability of ODN to interact with the binding of [3H]flumazenil is lost.	Lysine	20-26	diazepam binding inhibitor	Rattus norvegicus	30-33
16741238-5	2006	Examination of the IRAK-4 DD crystal structure reveals a single manganese ion coordinated to surface residues lysine-21 and aspartate-24.	Lysine	110-116	interleukin 1 receptor associated kinase 4	Homo sapiens	19-25
16531924-4	2006	METHODS: HYNIC was conjugated to the epsilon-amino group of Lys 3 residue at the N-terminal region of bombesin via succinimidyl-N-Boc-HYNIC at pH 9.0.	Lysine	60-63	gastrin releasing peptide	Homo sapiens	102-110
2154668-4	1990	When the C-terminal lysine of ODN is blocked with an NH2 group, the ability of ODN to interact with the binding of [3H]flumazenil is lost.	Lysine	20-26	diazepam binding inhibitor	Rattus norvegicus	79-82
2104892-7	1990	Lytically active LAK effector subsets were either CD8+ B220+ Ly-24+ or NK1.1+ B220+ Ly-24+.	Lysine	0-2	protein tyrosine phosphatase, receptor type, C	Mus musculus	55-59
16631083-6	2006	RESULTS: DTPA-Lys(IRDye800)-c(KRGDf), DTPA-Lys-c(KRGDf) and c(KRGDf) inhibited the adhesion of melanoma M21 cells to vitronectin-coated surface with the similar biological activity.	Lysine	14-17	vitronectin	Homo sapiens	117-128
16631083-6	2006	RESULTS: DTPA-Lys(IRDye800)-c(KRGDf), DTPA-Lys-c(KRGDf) and c(KRGDf) inhibited the adhesion of melanoma M21 cells to vitronectin-coated surface with the similar biological activity.	Lysine	43-47	vitronectin	Homo sapiens	117-128
16533046-1	2006	The Saccharomyces cerevisiae high-mobility group protein HMO1 is composed of two DNA-binding domains termed box A and box B, of which only box B is predicted to adopt a HMG fold, and a lysine-rich C-terminal extension.	Lysine	185-191	Hmo1p	Saccharomyces cerevisiae S288C	57-61
2104892-7	1990	Lytically active LAK effector subsets were either CD8+ B220+ Ly-24+ or NK1.1+ B220+ Ly-24+.	Lysine	0-2	protein tyrosine phosphatase, receptor type, C	Mus musculus	78-82
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	48-50	protein tyrosine phosphatase, receptor type, C	Mus musculus	42-46
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	48-50	protein tyrosine phosphatase, receptor type, C	Mus musculus	138-142
17163635-2	2006	Recent work using the yeast ubiquitin ligase SCF(Cdc4) and the ubiquitin conjugating enzyme, Cdc34, has helped to answer these questions by identifying the determinants of lysine-48 specific ubiquitin chain polymerization.	Lysine	172-178	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	93-98
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	144-146	protein tyrosine phosphatase, receptor type, C	Mus musculus	42-46
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Lysine	134-142	solute carrier family 7 member 1	Homo sapiens	63-96
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Lysine	134-142	solute carrier family 7 member 1	Homo sapiens	98-102
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	144-146	protein tyrosine phosphatase, receptor type, C	Mus musculus	138-142
3922403-0	1985	Glucose-6-phosphate dehydrogenase from Saccharomyces cerevisiae: characterization of a reactive lysine residue labeled with acetylsalicylic acid.	Lysine	96-102	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
3922403-1	1985	Glucose-6-phosphate dehydrogenase from Saccharomyces cerevisiae (bakers" yeast) reacts with acetylsalicylic acid, and this is accompanied by inactivation and modification of essentially one lysine residue per subunit.	Lysine	190-196	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
33797903-0	2021	Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.	Lysine	54-60	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	93-98
16415020-5	2006	Using reverse genetics, we demonstrated that a Lys(46)--&gt;Glu substitution in NS3 as well as a single Lys(315)--&gt;Glu change in E significantly impaired the growth of LGT in neuroblastoma cells and reduced its peripheral neurovirulence for SCID mice.	Lysine	47-50	KRAS proto-oncogene, GTPase	Homo sapiens	80-83
16337145-9	2006	Our study shows that ZNF76, a TBP-interacting transcriptional modulator, is regulated by both lysine modifications and alternative splicing.	Lysine	94-100	TATA-box binding protein	Homo sapiens	30-33
33232890-2	2021	PRC2 comprises a trimeric core of SUZ12, EED and EZH1/2, which together with RBBP4/7 is sufficient to catalyse mono-methylation, di-methylation and tri-methylation of histone H3 at lysine 27 (H3K27me1/2/3).	Lysine	181-187	RB binding protein 4, chromatin remodeling factor	Homo sapiens	77-84
16291740-4	2006	This activity is independent of MDM2 but requires a p53 nuclear export signal and acetylation of multiple lysines by p300.	Lysine	106-113	MDM2 proto-oncogene	Homo sapiens	32-36
15976810-2	2006	Here, we report that DJ-1 was sumoylated on a lysine residue at amino-acid number 130 (K130) by PIASxalpha or PIASy.	Lysine	46-52	protein inhibitor of activated STAT 4	Homo sapiens	110-115
33772590-1	2021	HP1 (Heterochromatin Protein 1), a key factor for the formation of heterochromatin, binds to the methylated lysine 9 of histone H3 (H3K9me), and represses transcription.	Lysine	108-114	chromobox 5	Homo sapiens	0-3
16282617-0	2005	Lysine requirement of finishing pigs administered porcine somatotropin by sustained-release implant.	Lysine	0-6	somatotropin	Sus scrofa	58-70
16213750-7	2005	To address limited half life or rapid clearance in mice, recombinant murine GM-CSF was modified by lysine-directed polyethylene glycol conjugation (PEGylation).	Lysine	99-105	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	76-82
33772590-1	2021	HP1 (Heterochromatin Protein 1), a key factor for the formation of heterochromatin, binds to the methylated lysine 9 of histone H3 (H3K9me), and represses transcription.	Lysine	108-114	chromobox 5	Homo sapiens	5-30
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	149-155	alpha fetoprotein	Mus musculus	54-57
16203738-7	2005	Like the founding family member p53, TA-p73 represses AFP expression by chromatin structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylated histone H3 lysine 9 levels.	Lysine	196-202	alpha fetoprotein	Mus musculus	54-57
33802993-6	2021	Furthermore, exposure to relatively non-toxic Fe@CeO2 NPs, but not the toxic Cr@CeO2 NPs, resulted in increased binding of MLL1 complex, a major histone lysine methylase mediating trimethylation of histone H3 lysine 4, at the NRF2 promoter.	Lysine	153-159	lysine methyltransferase 2A	Homo sapiens	123-127
16286008-0	2005	Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.	Lysine	49-55	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	18-22
16286008-5	2005	Chromatin immunoprecipitation and biochemical experiments indicate that the chromodomain of Eaf3 recruits Rpd3C(S) to nucleosomes methylated by Set2 on histone H3 lysine 36, leading to deacetylation of transcribed regions.	Lysine	163-169	Eaf3p	Saccharomyces cerevisiae S288C	92-96
16286008-5	2005	Chromatin immunoprecipitation and biochemical experiments indicate that the chromodomain of Eaf3 recruits Rpd3C(S) to nucleosomes methylated by Set2 on histone H3 lysine 36, leading to deacetylation of transcribed regions.	Lysine	163-169	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	144-148
33802993-6	2021	Furthermore, exposure to relatively non-toxic Fe@CeO2 NPs, but not the toxic Cr@CeO2 NPs, resulted in increased binding of MLL1 complex, a major histone lysine methylase mediating trimethylation of histone H3 lysine 4, at the NRF2 promoter.	Lysine	209-215	lysine methyltransferase 2A	Homo sapiens	123-127
33796843-3	2021	Here, we found that histone H2B is mainly degraded through the proteasome-mediated pathway, and the lysine-120 site of H2B is essential for its K48-linked polyubiquitination and degradation.	Lysine	100-106	H2B clustered histone 21	Homo sapiens	28-31
16292313-4	2005	Notably, Meisetz has catalytic activity for trimethylation, but not mono- or dimethylation, of lysine 4 of histone H3, and a transactivation activity that depends on its methylation activity.	Lysine	95-101	PR domain containing 9	Mus musculus	9-16
25040736-6	2014	Furthermore, we demonstrated that SIRT1 is able to bind to the PAI-1 promoter, resulting in a decrease in the acetylation of histone H4 lysine 16 (H4K16) on the PAI-1 promoter region.	Lysine	136-142	serpin family E member 1	Homo sapiens	63-68
16148010-5	2005	Both PIASxalpha/ARIP3 and the closely related PIASxbeta isoform specifically enhanced sumoylation of FLI-1 at Lys(67), located in its N-terminal activation domain.	Lysine	110-113	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	101-106
25040736-6	2014	Furthermore, we demonstrated that SIRT1 is able to bind to the PAI-1 promoter, resulting in a decrease in the acetylation of histone H4 lysine 16 (H4K16) on the PAI-1 promoter region.	Lysine	136-142	serpin family E member 1	Homo sapiens	161-166
34864549-6	2022	An AP180 N-terminal homology domain (1-289 aa) interacted with 18:0/22:6-PA, and a lysine-rich motif (K38-K39-K40) was essential for binding.	Lysine	83-89	synaptosomal-associated protein 91	Mus musculus	3-8
16298304-1	2005	Several receptors for human carbonic anhydrase II (HCAII) have been prepared by covalently attaching benzenesulfonamide carboxylates via aliphatic aminocarboxylic acid spacers of variable length to the side chain of a lysine residue in a designed 42 residue helix-loop-helix motif.	Lysine	218-224	carbonic anhydrase 2	Homo sapiens	28-49
16151465-1	2005	We have identified a gene polymorphism (K247R) within or close to the P-loop of BCR-ABL, which leads to the substitution of arginine for lysine.	Lysine	137-143	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-87
16109721-2	2005	In the sumoylation pathway, SUMO/Smt3 is transferred to substrate lysine residues through the thioester cascade of E1 (activating enzyme) and E2 (conjugating enzyme), and E3 (SUMO ligase) functions as an adaptor between E2 and each substrate.	Lysine	66-72	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	33-37
34581506-2	2022	JMJD6 assays employed NMR to monitor inhibitor binding and use of mass spectrometry to monitor JMJD6 catalysed lysine-hydroxylation.	Lysine	111-117	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	95-100
34718219-1	2022	Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links.	Lysine	75-81	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-19
16230382-4	2005	Direct lysine acetylation of KLF6 peptides can be shown by mass spectrometry.	Lysine	7-13	Kruppel like factor 6	Homo sapiens	29-33
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Lysine	9-15	Kruppel like factor 6	Homo sapiens	103-107
34718219-1	2022	Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links.	Lysine	75-81	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	21-24
34718219-1	2022	Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links.	Lysine	83-86	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	0-19
34718219-1	2022	Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links.	Lysine	83-86	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	21-24
16224104-4	2005	In the lambda-repressor-DNA complex, the epsilon-NH(2) group (hydrogen bond donor) of lysine-4 of lambda-repressor forms hydrogen bonds with the amide carbonyl atom of asparagine-55 (acceptor) and the O6 (acceptor) of CG6 of operator site O(L)1.	Lysine	86-92	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	201-244
34718219-4	2022	Compared to the wild-type (WT), LH2+/- collagen showed a significant decrease in the ratio of hydroxylysine (Hyl)- to the Lys-aldehyde-derived collagen cross-links without affecting the total number of aldehydes involved in cross-links.	Lysine	122-125	procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	Mus musculus	32-35
34508164-8	2022	In this study, we investigated the expression and distribution of acetylated alpha-tubulin and alpha-tubulin N-acetyltransferase 1 (alphaTAT1), an enzyme which acetylates Lys-40 in alpha-tubulin, in AB specimens, and analyzed how tubulin was acetylated by alphaTAT1 activation in a human AB cell line, AM-1.	Lysine	171-174	alpha tubulin acetyltransferase 1	Homo sapiens	95-130
16055500-10	2005	Furthermore, NLK induced the methylation of histone H3 at lysine-9 at A-Myb-bound promoter regions.	Lysine	58-64	nemo like kinase	Homo sapiens	13-16
16166645-3	2005	We find that modification of either of two specific lysine residues (Lys-48 and Lys-344) of gamma-tubulin, a known substrate for BRCA1-dependent ubiquitination activity, led to centrosome hyperactivity.	Lysine	52-58	BRCA1 DNA repair associated	Homo sapiens	129-134
34508164-8	2022	In this study, we investigated the expression and distribution of acetylated alpha-tubulin and alpha-tubulin N-acetyltransferase 1 (alphaTAT1), an enzyme which acetylates Lys-40 in alpha-tubulin, in AB specimens, and analyzed how tubulin was acetylated by alphaTAT1 activation in a human AB cell line, AM-1.	Lysine	171-174	alpha tubulin acetyltransferase 1	Homo sapiens	132-141
16166645-3	2005	We find that modification of either of two specific lysine residues (Lys-48 and Lys-344) of gamma-tubulin, a known substrate for BRCA1-dependent ubiquitination activity, led to centrosome hyperactivity.	Lysine	69-72	BRCA1 DNA repair associated	Homo sapiens	129-134
16166645-3	2005	We find that modification of either of two specific lysine residues (Lys-48 and Lys-344) of gamma-tubulin, a known substrate for BRCA1-dependent ubiquitination activity, led to centrosome hyperactivity.	Lysine	80-83	BRCA1 DNA repair associated	Homo sapiens	129-134
34750787-2	2022	alpha-Syn, which is encoded by the SNCA gene, is a lysine-rich soluble amphipathic protein normally expressed in neurons.	Lysine	51-57	synuclein alpha	Homo sapiens	0-9
16199873-3	2005	Targeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 protein (MEKK4(K1361R)).	Lysine	37-43	mitogen-activated protein kinase kinase kinase 4	Mus musculus	47-59
16199873-3	2005	Targeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 protein (MEKK4(K1361R)).	Lysine	37-43	mitogen-activated protein kinase kinase kinase 4	Mus musculus	61-66
34750787-2	2022	alpha-Syn, which is encoded by the SNCA gene, is a lysine-rich soluble amphipathic protein normally expressed in neurons.	Lysine	51-57	synuclein alpha	Homo sapiens	35-39
16199873-3	2005	Targeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 protein (MEKK4(K1361R)).	Lysine	37-43	mitogen-activated protein kinase kinase kinase 4	Mus musculus	95-100
16199873-3	2005	Targeted mutation of the active site lysine of MEK kinase 4 (MEKK4) produces a kinase-inactive MEKK4 protein (MEKK4(K1361R)).	Lysine	37-43	mitogen-activated protein kinase kinase kinase 4	Mus musculus	95-100
34400365-5	2022	The PLOD1 substrate lysine was elevated in the proband, however the enzymatic product hydroxylysine and total collagen content was not different, albeit despite collagen fibril narrowing and preservation of collagen turnover.	Lysine	20-26	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	4-9
16087749-1	2005	Set2 methylation of histone H3 at lysine 36 (K36) has recently been shown to be associated with RNA polymerase II (Pol II) elongation in Saccharomyces cerevisiae.	Lysine	34-40	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-4
34808502-10	2021	The silencing of KAT6A reduced the enrichment of histone H3 lysine 23 acetylation (H3K23ac) and RNA polymerase II (RNA pol II) on the promoter of YAP in sorafenib-resistant HCC cells.	Lysine	60-66	lysine acetyltransferase 6A	Homo sapiens	17-22
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	20-26	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	20-26	small ubiquitin like modifier 2	Homo sapiens	106-112
34954891-4	2022	The Euchromatin Histone Lysine Methyltransferase 1 (EHMT1) and Euchromatin Histone Lysine Methyltransferase 2 (EHMT2) that primarily mediate histone 3 lysine 9 di-methylation (H3K9me2), as well as methylation of non-histone proteins, are now recognized to be aberrantly expressed in many cancers.	Lysine	151-157	euchromatic histone lysine methyltransferase 1	Homo sapiens	52-57
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	20-26	small ubiquitin like modifier 3	Homo sapiens	118-124
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	20-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	small ubiquitin like modifier 2	Homo sapiens	106-112
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	small ubiquitin like modifier 2	Homo sapiens	106-112
16055710-3	2005	We report here that lysine 265 of c-Fos is conjugated by the peptidic posttranslational modifiers SUMO-1, SUMO-2, and SUMO-3 and that c-Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229.	Lysine	161-167	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
34992428-9	2021	Frequencies of XPD Lys751Gln genotypes in cases were 62.7% heterozygous Lys/Gln, 24% homozygous Lys/Lys and 13.3% homozygous Gln/Gln, while in the controls were 74.7%, 20%, and 5.3%, respectively.	Lysine	96-99	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	15-18
34992428-9	2021	Frequencies of XPD Lys751Gln genotypes in cases were 62.7% heterozygous Lys/Gln, 24% homozygous Lys/Lys and 13.3% homozygous Gln/Gln, while in the controls were 74.7%, 20%, and 5.3%, respectively.	Lysine	100-103	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	15-18
34418551-3	2021	Here we show that Arabidopsis UBC13A and UBC13B, the major drivers of lysine 63 (K63)-linked polyubiquitination, directly interact with PARPs/PARGs.	Lysine	70-76	poly(ADP-ribose) polymerase 2	Arabidopsis thaliana	136-141
15990871-6	2005	Furthermore, we show that lysine-1270 of BLM, which resides in the HRDC domain and is predicted to play a role in mediating interactions with DNA, is required for efficient dissolution.	Lysine	26-32	BLM RecQ like helicase	Homo sapiens	41-44
16002700-10	2005	Functional analysis indicated that Lys(68) and Glu(70) in the extracellular domain of h2B4 play a key role in the activation of human NK cells through 2B4/CD48 interaction.	Lysine	35-38	CD48 molecule	Homo sapiens	155-159
34783291-0	2021	Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.	Lysine	13-19	lysine demethylase 2B	Homo sapiens	48-53
15907800-4	2005	We found that double mutation of two lysine residues, K254 and K379, abrogated MDMX sumoylation in vivo.	Lysine	37-43	transformed mouse 3T3 cell double minute 4	Mus musculus	79-83
34607003-4	2021	METHODS: Differentially expressed miRNAs were provided by Gene Expression Omnibus (GEO) datasets and RT-qPCR examined RNA levels of miR-106a-5p and Jumonji domain-containing protein 6 (JMJD6), an enzyme causing lysine hydroxylation and arginine demethylation.	Lysine	211-217	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	148-183
15964811-4	2005	PLZF associates with p300 in vivo, and its ability to repress transcription is specifically dependent on HAT activity of p300 and acetylation of lysines in its C-terminal C2-H2 zinc finger motif.	Lysine	145-152	zinc finger and BTB domain containing 16	Homo sapiens	0-4
34607003-4	2021	METHODS: Differentially expressed miRNAs were provided by Gene Expression Omnibus (GEO) datasets and RT-qPCR examined RNA levels of miR-106a-5p and Jumonji domain-containing protein 6 (JMJD6), an enzyme causing lysine hydroxylation and arginine demethylation.	Lysine	211-217	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	185-190
34837535-7	2021	Additionally, we confirmed that RNF166 interacts with and forms lysine 63-linked polyubiquitin chains in Ku80.	Lysine	64-70	ring finger protein 166	Homo sapiens	32-38
15924414-9	2005	The observations suggest a model in which the known ion pair between lysine in TMD II and aspartate in TMD XI controls the conformation or relative position of TMD XI, which in turn controls additional TMDs in the C-terminal half of VAChT.	Lysine	69-75	solute carrier family 18 member A3	Rattus norvegicus	233-238
16077202-0	2005	Dissimilar effects of LY 294002 and PD 098059 in IGF-I-mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells.	Lysine	22-24	IGFI	Bos taurus	49-54
34787461-4	2022	In this work, we identified potential SUMO-conjugation motifs (SCMs) in E1B-55K proteins from HAdV species A to F. Mutational inactivation of these SCMs demonstrated that HAdV E1B-55K proteins are SUMOylated at a single lysine residue that is highly conserved among HAdV species B to E. Moreover, we provide evidence that E1B-55K SUMOylation is a potent regulator of intracellular localization and p53-mediated transcription in most HAdV species.	Lysine	220-226	small nucleolar RNA, H/ACA box 73A	Homo sapiens	322-325
15919894-4	2005	Sequence comparison of the VP1 capsid proteins of all HRVs revealed that the lysine in the HI loop, strictly conserved in the 12 minor group HRVs, is also present in 9 major group serotypes that are neutralized by soluble ICAM-1.	Lysine	77-83	intercellular adhesion molecule 1	Homo sapiens	222-228
15919894-5	2005	Despite the presence of this lysine, they are not neutralized by MBP-V33333 and fail to replicate in COS-7 cells and in HeLa cells in the presence of an ICAM-1-blocking antibody.	Lysine	29-35	intercellular adhesion molecule 1	Homo sapiens	153-159
34787461-5	2022	We also identified a lysine residue at position 101 (K101), which is unique to HAdV-C5 E1B-55K and specifically regulates its SUMOylation and nucleo-cytoplasmic shuttling.	Lysine	21-27	small nucleolar RNA, H/ACA box 73A	Homo sapiens	87-90
34795530-15	2021	Mechanically, KAT7 was able to bind to PD-L1 promoter and epigenetically induce PD-L1 expression by promoting the enrichment of histone H3 lysine 14 acetylation (H3K14ac) and RNA polymerase II on PD-L1 promoter.	Lysine	139-145	CD274 molecule	Homo sapiens	39-44
15788563-5	2005	SUMOylation assays in HeLa cells and Drosophila S2 cells reveal that lysine 439 is the major SUMO acceptor site.	Lysine	69-75	smt3	Drosophila melanogaster	0-4
15899873-5	2005	While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region.	Lysine	232-238	ankyrin repeat and SOCS box containing 3	Homo sapiens	105-109
34795530-15	2021	Mechanically, KAT7 was able to bind to PD-L1 promoter and epigenetically induce PD-L1 expression by promoting the enrichment of histone H3 lysine 14 acetylation (H3K14ac) and RNA polymerase II on PD-L1 promoter.	Lysine	139-145	CD274 molecule	Homo sapiens	80-85
34663924-1	2021	Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed-lineage leukemia-1), and produce in-frame fusions of KMT2A to other chromatin-regulatory proteins.	Lysine	122-128	lysine methyltransferase 2A	Homo sapiens	91-96
15823024-8	2005	However, model reactions involving the single amino acids lysine, arginine, and tyrosine, residues known to be involved in base contacts in the DNA:SSB complex, could be studied, and the adduct formed between N(alpha)-acetyllysine methyl ester and an 18-mer containing OG was tentatively characterized by electrospray ionization mass spectrometry as analogues of spiroiminodihydantoin and guanidinohydantoin.	Lysine	58-64	single-stranded DNA-binding protein	Escherichia coli	148-151
34663924-1	2021	Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed-lineage leukemia-1), and produce in-frame fusions of KMT2A to other chromatin-regulatory proteins.	Lysine	122-128	lysine methyltransferase 2A	Homo sapiens	162-186
34771652-0	2021	Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis.	Lysine	11-17	Fas ligand	Homo sapiens	130-134
15721299-1	2005	In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads to the expression of the primary response genes c-fos and early growth response gene egr-1.	Lysine	74-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	286-291
15611084-7	2005	Two PLSCR1 lysines occupy the canonical positions indicated as P2 and P5.	Lysine	11-18	phospholipid scramblase 1	Homo sapiens	4-10
34733415-4	2021	We demonstrate that K34 Lys residue in the DIX domain regulates subcellular localization of beta-catenin, thereby influencing downstream Wnt target gene expression.	Lysine	24-27	catenin beta 1	Homo sapiens	92-104
15632193-0	2005	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.	Lysine	52-58	sirtuin 1	Homo sapiens	0-5
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	37-40	sirtuin 1	Homo sapiens	78-83
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	37-40	sirtuin 1	Homo sapiens	124-129
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	50-53	sirtuin 1	Homo sapiens	78-83
34680099-4	2021	Glycation of ac-alphaSyn by methylglyoxal increases oligomer formation, as visualized by AFM in solution, resulting in decreased dynamics of the monomer amide backbone around the Lys residues, as measured using NMR.	Lysine	179-182	synuclein alpha	Homo sapiens	16-24
15632193-6	2005	Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation.	Lysine	50-53	sirtuin 1	Homo sapiens	124-129
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Lysine	90-93	prepronociceptin	Mus musculus	47-52
34680103-0	2021	The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.	Lysine	27-33	S100 calcium binding protein P	Homo sapiens	37-42
15713642-2	2005	Here, we report that steroidogenic factor 1 (SF-1) and liver receptor homolog 1 are repressed via posttranslational SUMO modification at conserved lysines within the hinge domain.	Lysine	147-154	splicing factor 1	Homo sapiens	21-49
34680103-7	2021	The results identify at least two S100P-dependent pathways of migration, one cell surface and the other intracellularly-linked, and identify its C-terminal lysine as a target for inhibiting multiple migration-promoting activities of S100P protein and S100P-driven metastasis.	Lysine	156-162	S100 calcium binding protein P	Homo sapiens	34-39
34680103-7	2021	The results identify at least two S100P-dependent pathways of migration, one cell surface and the other intracellularly-linked, and identify its C-terminal lysine as a target for inhibiting multiple migration-promoting activities of S100P protein and S100P-driven metastasis.	Lysine	156-162	S100 calcium binding protein P	Homo sapiens	251-256
34692483-1	2021	Set7/9 is a lysine-specific methyltransferase, which regulates the functioning of both the histone and non-histone substrates, thereby significantly affecting the global gene expression landscape.	Lysine	12-18	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
15728840-4	2005	Contrary to our expectation, we found that synphilin-1 is normally ubiquitinated by parkin in a nonclassical, proteasomal-independent manner that involves lysine 63 (K63)-linked polyubiquitin chain formation.	Lysine	155-161	synuclein alpha interacting protein	Homo sapiens	43-54
15728840-5	2005	Parkin-mediated degradation of synphilin-1 occurs appreciably only at an unusually high parkin to synphilin-1 expression ratio or when primed for lysine 48 (K48)-linked ubiquitination.	Lysine	146-152	synuclein alpha interacting protein	Homo sapiens	31-42
34696420-8	2021	Finally, E3 ubiquitin ligases for MAVS degradation were screened and identified and RNF5 targeting MAVS at Lysine 363 and 462 was shown to involve in MAVS degradation in aMPV/C-infected Vero cells.	Lysine	107-113	E3 ubiquitin-protein ligase RNF5	Chlorocebus sabaeus	84-88
15572352-2	2005	ATP-dependent uptake of histidine and lysine by isolated vacuolar membrane vesicles was impaired in YMR088c, a vacuolar basic amino acid transporter 1 (VBA1)-deleted strain, whereas uptake of tyrosine or calcium was little affected.	Lysine	38-44	Vba1p	Saccharomyces cerevisiae S288C	152-156
15572352-3	2005	This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane.	Lysine	29-35	Vba1p	Saccharomyces cerevisiae S288C	85-89
34606826-2	2021	Zhang and colleagues provide new understanding of memory formation by uncovering the lysine acetyltransferase SRC3 as the key driver of the novel posttranslational modification of calmodulin (CaM) acetylation, which regulates CaM"s activity and subsequent activation of CaMKII.	Lysine	85-91	nuclear receptor coactivator 3	Homo sapiens	110-114
15572352-3	2005	This defect in histidine and lysine uptake was complemented fully by introducing the VBA1 gene and partially by a gene encoding Vba1p fused with green fluorescent protein, which was determined to localize exclusively to the vacuolar membrane.	Lysine	29-35	Vba1p	Saccharomyces cerevisiae S288C	128-133
15569707-0	2005	Regulation of lysine catabolism in Arabidopsis through concertedly regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus.	Lysine	14-20	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	138-143
34519438-1	2021	The phenotypic variability associated with pathogenic variants in Lysine Acetyltransferase 6B (KAT6B, a.k.a.	Lysine	66-72	lysine acetyltransferase 6B	Homo sapiens	95-100
34599168-3	2021	SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127.	Lysine	75-81	geminin DNA replication inhibitor	Homo sapiens	64-71
15569707-0	2005	Regulation of lysine catabolism in Arabidopsis through concertedly regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus.	Lysine	14-20	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	144-147
15569707-1	2005	Lysine catabolism in plants is initiated by a bifunctional LKR/SDH (lysine-ketoglutarate reductase/saccharopine dehydrogenase) enzyme encoded by a single LKR/SDH gene.	Lysine	0-6	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	59-66
15569707-1	2005	Lysine catabolism in plants is initiated by a bifunctional LKR/SDH (lysine-ketoglutarate reductase/saccharopine dehydrogenase) enzyme encoded by a single LKR/SDH gene.	Lysine	0-6	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	68-125
15569707-1	2005	Lysine catabolism in plants is initiated by a bifunctional LKR/SDH (lysine-ketoglutarate reductase/saccharopine dehydrogenase) enzyme encoded by a single LKR/SDH gene.	Lysine	0-6	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	154-161
34403482-3	2021	Here, using whole genome bisulfite sequencing (WGBS) and chromatin immunoprecipitation-sequencing (ChIP-Seq), we mapped the genome-wide patterns of differential DNA methylation and histone H3 lysine 18 acetylation (H3K18ac) in wild-type and hda6 mutant strains.	Lysine	192-198	histone deacetylase 6	Arabidopsis thaliana	241-245
15569707-3	2005	To elucidate the regulation of lysine catabolism in Arabidopsis through these two gene products of the AtLKR/SDH gene, an analysis was carried out on the effects of the hormones, abscisic acid and jasmonate, as well as various metabolic and stress signals, including lysine itself, on their mRNA and protein levels.	Lysine	31-37	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	103-108
15569707-3	2005	To elucidate the regulation of lysine catabolism in Arabidopsis through these two gene products of the AtLKR/SDH gene, an analysis was carried out on the effects of the hormones, abscisic acid and jasmonate, as well as various metabolic and stress signals, including lysine itself, on their mRNA and protein levels.	Lysine	31-37	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	109-112
15569707-3	2005	To elucidate the regulation of lysine catabolism in Arabidopsis through these two gene products of the AtLKR/SDH gene, an analysis was carried out on the effects of the hormones, abscisic acid and jasmonate, as well as various metabolic and stress signals, including lysine itself, on their mRNA and protein levels.	Lysine	267-273	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	103-108
15569707-3	2005	To elucidate the regulation of lysine catabolism in Arabidopsis through these two gene products of the AtLKR/SDH gene, an analysis was carried out on the effects of the hormones, abscisic acid and jasmonate, as well as various metabolic and stress signals, including lysine itself, on their mRNA and protein levels.	Lysine	267-273	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	109-112
15569707-5	2005	These results suggest that lysine catabolism is regulated primarily by the first enzyme LKR, while the excess level of SDH enables efficient flux of lysine catabolism following the LKR step.	Lysine	27-33	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	88-91
15569707-5	2005	These results suggest that lysine catabolism is regulated primarily by the first enzyme LKR, while the excess level of SDH enables efficient flux of lysine catabolism following the LKR step.	Lysine	149-155	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	119-122
15569707-5	2005	These results suggest that lysine catabolism is regulated primarily by the first enzyme LKR, while the excess level of SDH enables efficient flux of lysine catabolism following the LKR step.	Lysine	149-155	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	181-184
34545456-2	2021	Here, we aimed to discuss the effects of FOXP4-AS1/enhancer of zeste homolog 2 (EZH2)/trimethylation of lysine 27 on histone H3 (H3K27me3)/zinc finger CCCH-type containing 12D (ZC3H12D) axis on HCC.	Lysine	104-110	zinc finger CCCH-type containing 12D	Homo sapiens	177-184
15569707-7	2005	To test whether the enhanced expression of the LKR/SDH gene under various hormonal and metabolic signals is correlated with enhanced lysine catabolism, wild-type Arabidopsis and a knockout mutant lacking lysine catabolism were exposed to abscisic acid and sugar starvation.	Lysine	133-139	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	47-54
15569707-7	2005	To test whether the enhanced expression of the LKR/SDH gene under various hormonal and metabolic signals is correlated with enhanced lysine catabolism, wild-type Arabidopsis and a knockout mutant lacking lysine catabolism were exposed to abscisic acid and sugar starvation.	Lysine	204-210	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	47-54
34621741-2	2021	ATM activation is complex, and primarily mediated by the lysine acetyltransferase Tip60.	Lysine	57-63	ATM serine/threonine kinase	Homo sapiens	0-3
15504745-8	2005	A chimeric Rac1 protein in which the Rac1 C-terminal polybasic domain, which contains six lysines or arginines, was replaced with that of the human Rac2 polybasic domain containing only three basic residues, also reconstituted superoxide production and chemotaxis, whereas expression of a Rac2 derivative in which the polybasic domain was replaced with that of Rac1 did not and resulted in disoriented cell motility.	Lysine	90-97	Rac family small GTPase 1	Homo sapiens	11-15
15638535-3	2005	While each engineered protein contains identical CS5 cell-binding domain sequences, the lysine residues that serve as cross-linking sites are either (i) within the elastin cassettes or (ii) confined to the ends of the protein.	Lysine	88-94	elastin	Homo sapiens	164-171
34621741-3	2021	Epigenetic changes can regulate this Tip60-dependent activation of ATM, requiring the interaction of Tip60 with tri-methylated histone 3 lysine 9 (H3K9me3).	Lysine	137-143	ATM serine/threonine kinase	Homo sapiens	67-70
34397208-0	2021	Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kdelta.	Lysine	29-35	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	64-73
15921168-0	2005	Hb Kurosaki [alpha7(A5)Lys -->Glu (AAG --> GAG)]: an alpha2-globin gene mutation found in Thailand.	Lysine	23-26	N-methylpurine DNA glycosylase	Homo sapiens	35-38
15921168-1	2005	Hb Kurosaki [alpha 7(A5)Lys --> Glu (AAG --> GAG)], has been found for the first time in Thailand.	Lysine	24-27	N-methylpurine DNA glycosylase	Homo sapiens	37-40
15921168-4	2005	Direct DNA sequence analysis of selectively amplified segments of the alpha1 and alpha2 genes showed that codon 7 of the alpha2-globin gene was heterozygous for AAG (Lys) and GAG (Glu).	Lysine	166-169	N-methylpurine DNA glycosylase	Homo sapiens	161-164
34397208-3	2021	We have developed novel, selective inhibitors of phosphoinositide 3-kinase delta (PI3Kdelta) which acylate the catalytic lysine, Lys779, using activated esters as the reactive electrophiles.	Lysine	121-127	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-80
34397208-3	2021	We have developed novel, selective inhibitors of phosphoinositide 3-kinase delta (PI3Kdelta) which acylate the catalytic lysine, Lys779, using activated esters as the reactive electrophiles.	Lysine	121-127	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	82-91
34397208-7	2021	An enzymatic digest coupled with tandem mass spectrometry identified Lys779 as the covalent binding site, and a biochemical activity assay confirmed that PI3Kdelta inhibition was a direct result of covalent lysine acylation.	Lysine	207-213	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	154-163
34334531-1	2021	We established an IL-2 and IL-4 (IL2/4) - dependent adult T-cell leukemia/lymphoma (ATLL) cell line (YG-PLL) by adding poly-L-lysine (PLL) to the culture medium.	Lysine	119-132	interleukin 24	Homo sapiens	27-31
15550930-3	2004	Using time-lapse microscopy of mammalian cells expressing green-fluorescent-protein-tagged Dnmt1 and DsRed-tagged DNA Ligase I as a cell cycle progression marker, we have found that Dnmt1 associates with chromatin during G2 and M. This association is mediated by a specific targeting sequence, shows strong preference for constitutive but not facultative heterochromatin and is independent of heterochromatin-specific histone H3 Lys 9 trimethylation, SUV39H and HP1.	Lysine	429-432	DNA methyltransferase 1	Homo sapiens	182-187
34334531-1	2021	We established an IL-2 and IL-4 (IL2/4) - dependent adult T-cell leukemia/lymphoma (ATLL) cell line (YG-PLL) by adding poly-L-lysine (PLL) to the culture medium.	Lysine	119-132	interleukin 24	Homo sapiens	33-38
34264172-2	2021	Transglutaminase 2 (TG2) is an enzyme that crosslinks glutamine and lysine residues and is involved in IPF pathogenesis.	Lysine	68-74	transglutaminase 2, C polypeptide	Mus musculus	0-18
15606774-3	2004	However, the putative catalytic Ser-Lys dyad was recently suggested through sequence comparison of more than 100 Lon proteases from various sources.	Lysine	36-39	putative ATP-dependent Lon protease	Escherichia coli	113-116
34264172-2	2021	Transglutaminase 2 (TG2) is an enzyme that crosslinks glutamine and lysine residues and is involved in IPF pathogenesis.	Lysine	68-74	transglutaminase 2, C polypeptide	Mus musculus	20-23
15378692-7	2004	Further analysis using mass spectrometry and Edman degradation sequencing demonstrated that five conserved lysine residues (Lys 28, 60, 63, 72 and 96) within the collagenous domain of bovine adiponectin are hydroxylated and glycosylated by a glucosyl alpha(1-2)galactosyl group.	Lysine	107-113	adiponectin, C1Q and collagen domain containing	Bos taurus	191-202
15378692-7	2004	Further analysis using mass spectrometry and Edman degradation sequencing demonstrated that five conserved lysine residues (Lys 28, 60, 63, 72 and 96) within the collagenous domain of bovine adiponectin are hydroxylated and glycosylated by a glucosyl alpha(1-2)galactosyl group.	Lysine	124-127	adiponectin, C1Q and collagen domain containing	Bos taurus	191-202
34331109-2	2021	ASH1 dimethylates histone H3 at lysine 36 via its SET domain.	Lysine	32-38	absent, small, or homeotic discs 1	Drosophila melanogaster	0-4
15520273-6	2004	ELF7 and ELF8 are required for the enhancement of histone 3 trimethylation at Lys 4 in FLC chromatin.	Lysine	78-81	hydroxyproline-rich glycoprotein family protein	Arabidopsis thaliana	0-4
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	cyclin CLN1	Saccharomyces cerevisiae S288C	52-56
15546210-9	2004	Thus, [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN has the potential for imaging BN/GRP receptor-positive lesions.	Lysine	16-19	gastrin releasing peptide	Homo sapiens	84-87
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	mitogen-activated protein kinase kinase STE7	Saccharomyces cerevisiae S288C	169-173
15493016-4	2004	Interestingly, Eed associates with Ezh2 to form a complex possessing histone methyltransferase activity predominantly for H3 Lys-27.	Lysine	125-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	35-39
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	Spc29p	Saccharomyces cerevisiae S288C	246-251
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	Spc110p	Saccharomyces cerevisiae S288C	260-266
15326173-0	2004	Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine.	Lysine	98-104	metacaspase 4	Arabidopsis thaliana	21-26
34433666-10	2021	As an underlying mechanism, we showed TRIM47-dependent lysine 27-linked polyubiquitination of PKC-epsilon.	Lysine	55-61	protein kinase C epsilon	Homo sapiens	94-105
15457214-0	2004	Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.	Lysine	37-44	chromomethylase 3	Arabidopsis thaliana	84-100
34431785-4	2021	MLL proteins associated with the HBO1 complex through multiple contacts mediated mainly by the ING4/5 and PHF16 subunits in a chromatin-bound context where histone H3 lysine 4 tri-methylation marks were present.	Lysine	167-173	lysine methyltransferase 2A	Homo sapiens	0-3
15299006-6	2004	O2 and CO binding equilibrium studies on neuroglobin mutants strongly suggest that the bound O2 is stabilized by interactions with His(E7) and that this residue functions as a major Bohr group in the presence of Lys(E10).	Lysine	212-215	neuroglobin	Homo sapiens	41-52
34431785-4	2021	MLL proteins associated with the HBO1 complex through multiple contacts mediated mainly by the ING4/5 and PHF16 subunits in a chromatin-bound context where histone H3 lysine 4 tri-methylation marks were present.	Lysine	167-173	lysine acetyltransferase 7	Homo sapiens	33-37
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	85-90
15383321-3	2004	In this paper, we describe a novel protein LYsine-RIch CEACAM1 co-isolated (LYRIC) that is widely expressed and highly conserved between species.	Lysine	43-49	CEA cell adhesion molecule 1	Homo sapiens	55-62
15367667-7	2004	BRCA1/BARD1 ubiquitinated lysines 48 and 344 of gamma-tubulin in vitro, and expression in cells of gamma-tubulin K48R caused a marked amplification of centrosomes.	Lysine	26-33	BRCA1 DNA repair associated	Homo sapiens	0-5
15367667-7	2004	BRCA1/BARD1 ubiquitinated lysines 48 and 344 of gamma-tubulin in vitro, and expression in cells of gamma-tubulin K48R caused a marked amplification of centrosomes.	Lysine	26-33	BRCA1 associated RING domain 1	Homo sapiens	6-11
34251376-9	2021	In addition, results showed that lysine residues influenced the binding event, in which the presence of an extra lysine stabilized the alpha-syn-PQQ complex, and the absence of a lysine significantly decreased the interaction of alpha-syn with PQQ.	Lysine	33-39	synuclein alpha	Homo sapiens	135-144
34251376-9	2021	In addition, results showed that lysine residues influenced the binding event, in which the presence of an extra lysine stabilized the alpha-syn-PQQ complex, and the absence of a lysine significantly decreased the interaction of alpha-syn with PQQ.	Lysine	33-39	synuclein alpha	Homo sapiens	229-238
34251376-9	2021	In addition, results showed that lysine residues influenced the binding event, in which the presence of an extra lysine stabilized the alpha-syn-PQQ complex, and the absence of a lysine significantly decreased the interaction of alpha-syn with PQQ.	Lysine	113-119	synuclein alpha	Homo sapiens	135-144
15476952-2	2004	Recently, a UII-related peptide (URP) has been isolated from the rat brain and its sequence has been established as H-Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH.	Lysine	134-137	urotensin 2B	Rattus norvegicus	12-31
15476952-2	2004	Recently, a UII-related peptide (URP) has been isolated from the rat brain and its sequence has been established as H-Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH.	Lysine	134-137	urotensin 2B	Rattus norvegicus	33-36
34251376-9	2021	In addition, results showed that lysine residues influenced the binding event, in which the presence of an extra lysine stabilized the alpha-syn-PQQ complex, and the absence of a lysine significantly decreased the interaction of alpha-syn with PQQ.	Lysine	179-185	synuclein alpha	Homo sapiens	229-238
34286667-4	2022	Here, we investigate the role in autophagy of KANSL1, a member of the nonspecific lethal complex, which acetylates histone H4 on lysine 16 (H4K16ac) to facilitate transcriptional activation.	Lysine	129-135	KAT8 regulatory NSL complex subunit 1	Homo sapiens	46-52
15192092-3	2004	SF-1 was modified predominantly at Lys(194) and much less at Lys(119) when free SUMO-1 was supplied.	Lysine	35-38	splicing factor 1	Homo sapiens	0-4
34272458-6	2021	We found a higher association of VCAM-1 gene with active histone H3 trimethylated on lysine 4, leading to increased NF-kappaB accessibility in senescent ECs.	Lysine	85-91	vascular cell adhesion molecule 1	Mus musculus	33-39
15192092-3	2004	SF-1 was modified predominantly at Lys(194) and much less at Lys(119) when free SUMO-1 was supplied.	Lysine	61-64	splicing factor 1	Homo sapiens	0-4
15192092-4	2004	Mutations of Lys(194) and Lys(119) enhanced transcriptional activity of SF-1, although the DNA binding activity of SF-1 was not affected.	Lysine	13-16	splicing factor 1	Homo sapiens	72-76
15192092-4	2004	Mutations of Lys(194) and Lys(119) enhanced transcriptional activity of SF-1, although the DNA binding activity of SF-1 was not affected.	Lysine	26-29	splicing factor 1	Homo sapiens	72-76
34345217-8	2021	Additionally, our findings showed that MyRF was cleaved via a highly conserved serine-lysine catalytic dyad mechanism and that cleavage would be activated only if the ICA domains were organized as trimers.	Lysine	86-92	myelin regulatory factor	Homo sapiens	39-43
15159396-11	2004	E255I-Kex2 exhibited significantly decreased recognition of P(4) Arg in a tetrapeptide substrate with Lys at P(1), although the general pattern of selectivity for aliphatic residues at P(4) remained unchanged.	Lysine	102-105	crystallin gamma F, pseudogene	Homo sapiens	109-113
34247373-6	2021	NGS revealed that both children have carried pathogenic variants of the ANKRD11 gene (c.1903_1907del and c.4911delT), which resulted in shifting of amino acid sequences starting from the Lysine and Proline at positions 635 and 1638, respectively.	Lysine	187-193	ankyrin repeat domain containing 11	Homo sapiens	72-79
15334458-4	2004	Proteases that target the Lys-Lys cleavage site, including cathepsin B, activate probe fluorescence.	Lysine	26-29	cathepsin B	Mus musculus	59-70
15334458-4	2004	Proteases that target the Lys-Lys cleavage site, including cathepsin B, activate probe fluorescence.	Lysine	30-33	cathepsin B	Mus musculus	59-70
34215303-6	2021	METHODS: We used a mass spectrometry approach to characterize Tau PTMs on a detergent-soluble fraction of human AD and control brain tissue, which led to the discovery of novel lysine methylation events.	Lysine	177-183	microtubule associated protein tau	Homo sapiens	62-65
15231737-9	2004	Importantly, recruitment of Suz12, Ezh2 and Eed to target promoters coincides with methylation of histone H3 on Lys 27.	Lysine	112-115	embryonic ectoderm development	Homo sapiens	44-47
34215303-11	2021	Knock down and inhibitor studies supported by proteomics data led to the identification of SETD7 as a novel lysine methyltransferase for Tau.	Lysine	108-114	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	91-96
34215303-11	2021	Knock down and inhibitor studies supported by proteomics data led to the identification of SETD7 as a novel lysine methyltransferase for Tau.	Lysine	108-114	microtubule associated protein tau	Homo sapiens	137-140
34192545-7	2021	TIM enhances the interaction between the 53BP1 Tudor domain and dimethylated lysine 20 of histone H4.	Lysine	77-83	tumor protein p53 binding protein 1	Homo sapiens	41-46
15247373-1	2004	The opaque2 (o2) mutation increases the Lys content of maize (Zea mays) endosperm by reducing the synthesis of zein storage proteins and increasing the accumulation of other types of cellular proteins.	Lysine	40-43	regulatory protein opaque-2	Zea mays	4-11
15247373-1	2004	The opaque2 (o2) mutation increases the Lys content of maize (Zea mays) endosperm by reducing the synthesis of zein storage proteins and increasing the accumulation of other types of cellular proteins.	Lysine	40-43	regulatory protein opaque-2	Zea mays	13-15
15247373-8	2004	Thus, higher levels of eEF1A in o2 mutants may be related to a more extensive cytoskeletal network surrounding the rough endoplasmic reticulum and increased synthesis of cytoskeleton-associated proteins, all of which contribute significantly to the Lys content of the endosperm.	Lysine	249-252	regulatory protein opaque-2	Zea mays	32-34
34192545-7	2021	TIM enhances the interaction between the 53BP1 Tudor domain and dimethylated lysine 20 of histone H4.	Lysine	77-83	H4 clustered histone 6	Homo sapiens	90-100
34155106-3	2021	Here, we study a prototype for these receptors, a DAP12-NKG2C 2:1 heterotrimeric complex, in which the two DAP12 subunits each contribute a single transmembrane Asp residue, and the NKG2C subunit contributes a Lys to form the complex.	Lysine	210-213	transmembrane immune signaling adaptor TYROBP	Homo sapiens	50-55
15186161-5	2004	The introduction of positively charged lysines at the N-terminus provided an additional 2.4 kJ/mol of stabilization, affording a GB1p mutant that is 86 +/- 3% folded at 25 degrees C with a melting temperature of 60 +/- 2 degrees C. The trpzip version of this peptide, in which three of the hydrophobic core residues were mutated to tryptophan, yielded a sequence that melted at 85 degrees C. Throughout, fold populations and melting temperatures were derived from the mutation and temperature dependence of proton chemical shifts and were corroborated by circular dichroism (CD) melts.	Lysine	39-46	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	129-133
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Lysine	75-78	proprotein convertase subtilisin/kexin type 1	Mus musculus	190-213
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Lysine	75-78	prepronociceptin	Mus musculus	34-39
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Lysine	75-78	proprotein convertase subtilisin/kexin type 1	Mus musculus	190-213
34179622-11	2021	Lysine residue K228 with both KCr and Khib modifications in ENO1 was on its surface and made it accessible for p300 mediating dynamic modifications.	Lysine	0-6	enolase 1	Homo sapiens	60-64
34107997-8	2021	In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation.	Lysine	81-87	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	69-72
15214256-11	2004	Men, women, and children in the lysine-supplemented families had significant increases in CD4, CD8, and complement C3 as compared with controls.	Lysine	32-38	CD8a molecule	Homo sapiens	95-98
15214256-11	2004	Men, women, and children in the lysine-supplemented families had significant increases in CD4, CD8, and complement C3 as compared with controls.	Lysine	32-38	complement C3	Homo sapiens	104-117
34107997-8	2021	In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation.	Lysine	81-87	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	73-77
34107997-8	2021	In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation.	Lysine	81-87	sirtuin 1	Mus musculus	114-157
34107997-8	2021	In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation.	Lysine	81-87	sirtuin 1	Mus musculus	159-164
15331327-7	2004	These results indicate that Glu13 in IL-13 associates with IL-4Ralpha, and mutation to lysine decreases its binding ability to IL-4Ralpha chain.	Lysine	87-93	interleukin 4 receptor	Homo sapiens	127-137
34124072-9	2021	Moreover, we found that LINC02678 knockdown impaired the occupancy capacity of EZH2 and trimethylation of lysine 27 on histone 3 (H3K27me3) at the promoter region of cyclin dependent kinase inhibitor 1B (CDKN1B) and E-cadherin, as confirmed by ChIP-qPCR.	Lysine	106-112	cyclin dependent kinase inhibitor 1B	Homo sapiens	166-202
15190946-2	2004	Recent reports name the acyl-CoA : diacylglycerol acyltransferase (DGAT1) gene on BTA14 as a potential candidate gene, with a nonconservative substitution of lysine by alanine (K232A) producing a major effect on milk composition and yield.	Lysine	158-164	diacylglycerol O-acyltransferase 1	Bos taurus	67-72
34124072-9	2021	Moreover, we found that LINC02678 knockdown impaired the occupancy capacity of EZH2 and trimethylation of lysine 27 on histone 3 (H3K27me3) at the promoter region of cyclin dependent kinase inhibitor 1B (CDKN1B) and E-cadherin, as confirmed by ChIP-qPCR.	Lysine	106-112	cyclin dependent kinase inhibitor 1B	Homo sapiens	204-210
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	53-58
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	lysine demethylase 3B	Homo sapiens	75-81
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	59-62
34164016-0	2021	Fluorogenic probes for detecting deacylase and demethylase activity towards post-translationally-modified lysine residues.	Lysine	106-112	methyl-CpG binding domain protein 2	Homo sapiens	47-58
15332621-4	2004	Some of these elastin domains have been modified to contain lysine; this amino acid can be used for crosslinking purposes.	Lysine	60-66	elastin	Homo sapiens	14-21
15073296-5	2004	Mutations in Asp(8) and Asp(9) residues, postulated to form the acidic Mg(2+)-binding pocket, and the invariant Lys(104) of DevR, abrogated phosphoryl transfer from DevS(201) to DevR.	Lysine	112-115	two component transcriptional regulator DevR	Mycobacterium tuberculosis H37Rv	124-128
35489065-3	2022	Four acetylated lysine residues could be mapped within the basic C-terminal region of SSRP1, while three phosphorylated serine/threonine residues were identified in the acidic C-terminal region of SPT16.	Lysine	16-22	high mobility group	Arabidopsis thaliana	86-91
15023334-4	2004	Here, we identify eight lysines in Ku70 that are targets for acetylation in vivo.	Lysine	24-31	X-ray repair cross complementing 6	Homo sapiens	35-39
35526384-9	2022	In CBZ-treated groups, 29 and 30 peptides showed significantly increased respectively in HLA-A*24:02 and HLA-B*15:02 positive cells comprising Lysine in POmega, but the sources of these lysine peptides are different.	Lysine	143-149	major histocompatibility complex, class I, B	Homo sapiens	105-110
15016089-3	2004	The novel agonist [Arg(14),Lys(15)]N/OFQ also inhibited [(3)H]-5-HT overflow, but the concentration-response curve was biphasic and the efficacy higher ( approximately -45%).	Lysine	27-30	prepronociceptin	Mus musculus	35-40
35503397-6	2022	Mechanistically, SMYD2 physically interacts with HNRNPK and mediates lysine monomethylation at K422 of HNRNPK, which substantially increases RNA binding activity.	Lysine	69-75	SET and MYND domain containing 2	Homo sapiens	17-22
15086544-1	2004	Elastic fiber formation involves the secretion of tropoelastin which is converted to insoluble elastin by cross-linking, initiated by the oxidative deamination of lysine residues by lysyl oxidase.	Lysine	163-169	elastin	Homo sapiens	50-62
15086544-1	2004	Elastic fiber formation involves the secretion of tropoelastin which is converted to insoluble elastin by cross-linking, initiated by the oxidative deamination of lysine residues by lysyl oxidase.	Lysine	163-169	elastin	Homo sapiens	55-62
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	intercellular adhesion molecule 1	Homo sapiens	0-6
35574370-2	2022	Here, we found that lncRNA PRADX was overexpressed in the mesenchymal GBM and was transcriptionally regulated by RUNX1-CBFbeta complex, overexpressed PRADX suppressed BLCAP expression via interacting with EZH2 and catalyzing trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	243-249	RUNX family transcription factor 1	Homo sapiens	113-118
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	163-166	signal transducer and activator of transcription 1	Homo sapiens	203-208
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Lysine	185-188	intercellular adhesion molecule 1	Homo sapiens	0-6
14665623-0	2004	The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site.	Lysine	82-85	putative ATP-dependent Lon protease	Escherichia coli	41-44
35460275-2	2022	Down regulation of MIR156A/MIR156C, the two major sources of miR156, is accompanied by a decrease in acetylation of histone 3 lysine 27 (H3K27ac) and an increase in trimethylation of H3K27 (H3K27me3) at MIR156A/MIR156C in Arabidopsis.	Lysine	126-132	MIR156c	Arabidopsis thaliana	27-34
35452683-0	2022	EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1alpha is repressed by SET7-catalyzed lysine methylation.	Lysine	108-114	KMT5A pseudogene 1	Homo sapiens	93-97
14665623-7	2004	Within the active site, the proximity of Lys(722) to the side chain of the mutated Ala(679) and the absence of other potential catalytic side chains establish that Lon employs a Ser(679)-Lys(722) dyad for catalysis.	Lysine	41-44	putative ATP-dependent Lon protease	Escherichia coli	164-167
14665623-7	2004	Within the active site, the proximity of Lys(722) to the side chain of the mutated Ala(679) and the absence of other potential catalytic side chains establish that Lon employs a Ser(679)-Lys(722) dyad for catalysis.	Lysine	187-190	putative ATP-dependent Lon protease	Escherichia coli	164-167
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	27-33	KMT5A pseudogene 1	Homo sapiens	49-53
35452683-3	2022	Here, we identified that a lysine monomethylase, SET7, catalyzes EGLN1 methylation on lysine 297, resulting in the repression of EGLN1 activity in catalyzing prolyl hydroxylation of HIF1alpha.	Lysine	86-92	KMT5A pseudogene 1	Homo sapiens	49-53
14765118-5	2004	We show that targeting of HP1beta to heterochromatin requires shadow domain interactions with PXVXL-containing proteins in addition to chromo domain recognition of Lys-9-methylated histone H3.	Lysine	164-167	chromobox 1	Mus musculus	26-33
35427207-4	2022	Assay for transposase-accessible chromatin using sequencing and chromatin immunoprecipitation experiments elucidated that histone 3 lysine 27 acetylation (H3K27ac) activated the chromosome region opening in the LINC00941 promoter.	Lysine	132-138	long intergenic non-protein coding RNA 941	Homo sapiens	211-220
14638690-3	2004	Here we report that BRCA1-BARD1 catalyzes Lys-6-linked polyubiquitin chain formation.	Lysine	42-45	BRCA1 DNA repair associated	Homo sapiens	20-25
14638690-3	2004	Here we report that BRCA1-BARD1 catalyzes Lys-6-linked polyubiquitin chain formation.	Lysine	42-45	BRCA1 associated RING domain 1	Homo sapiens	26-31
14638690-5	2004	BRCA1-BARD1 preferentially utilizes ubiquitin with a single Lys residue at Lys-6 or Lys-29 to mediate autoubiquitination of BRCA1 in vivo.	Lysine	60-63	BRCA1 DNA repair associated	Homo sapiens	0-5
35458660-3	2022	The novel amino acid hypusine is a posttranslational modification (PTM) that occurs in eukaryotic initiation factor 5A (EIF5A) at a specific lysine residue.	Lysine	141-147	eukaryotic translation initiation factor 5A	Homo sapiens	87-118
14638690-5	2004	BRCA1-BARD1 preferentially utilizes ubiquitin with a single Lys residue at Lys-6 or Lys-29 to mediate autoubiquitination of BRCA1 in vivo.	Lysine	60-63	BRCA1 associated RING domain 1	Homo sapiens	6-11
14638690-5	2004	BRCA1-BARD1 preferentially utilizes ubiquitin with a single Lys residue at Lys-6 or Lys-29 to mediate autoubiquitination of BRCA1 in vivo.	Lysine	60-63	BRCA1 DNA repair associated	Homo sapiens	124-129
14638690-7	2004	The BRCA1-BARD1-mediated Lys-6-linked polyubiquitin chains are deubiquitinated by 26 S proteasome in vitro, whereas autoubiquitinated CUL1 through Lys-48-linked polyubiquitin chains is degraded.	Lysine	25-28	BRCA1 DNA repair associated	Homo sapiens	4-9
14638690-7	2004	The BRCA1-BARD1-mediated Lys-6-linked polyubiquitin chains are deubiquitinated by 26 S proteasome in vitro, whereas autoubiquitinated CUL1 through Lys-48-linked polyubiquitin chains is degraded.	Lysine	25-28	BRCA1 associated RING domain 1	Homo sapiens	10-15
14638690-9	2004	Hence, the results indicate that BRCA1-BARD1 mediates novel polyubiquitin chains that may be distinctly edited by 26 S proteasome from conventional Lys-48-linked polyubiquitin chains.	Lysine	148-151	BRCA1 DNA repair associated	Homo sapiens	33-38
35458660-3	2022	The novel amino acid hypusine is a posttranslational modification (PTM) that occurs in eukaryotic initiation factor 5A (EIF5A) at a specific lysine residue.	Lysine	141-147	eukaryotic translation initiation factor 5A	Homo sapiens	120-125
14638690-9	2004	Hence, the results indicate that BRCA1-BARD1 mediates novel polyubiquitin chains that may be distinctly edited by 26 S proteasome from conventional Lys-48-linked polyubiquitin chains.	Lysine	148-151	BRCA1 associated RING domain 1	Homo sapiens	39-44
35394699-7	2022	WHSC1 further increased the expression of DNA topoisomerase II alpha (TOP2A) in HCC by inducing the dimethylation of histone H3 lysine 36 (H3K36me2) in the TOP2A promoter region.	Lysine	128-134	DNA topoisomerase II alpha	Homo sapiens	70-75
14504096-6	2004	CRP binding studies with these mutants demonstrated that the exchange of lysine at position 59 for the corresponding murine glutamate substantially reduced binding to CRP.	Lysine	73-79	C-reactive protein, pentraxin-related	Mus musculus	0-3
35394699-7	2022	WHSC1 further increased the expression of DNA topoisomerase II alpha (TOP2A) in HCC by inducing the dimethylation of histone H3 lysine 36 (H3K36me2) in the TOP2A promoter region.	Lysine	128-134	DNA topoisomerase II alpha	Homo sapiens	156-161
14504096-6	2004	CRP binding studies with these mutants demonstrated that the exchange of lysine at position 59 for the corresponding murine glutamate substantially reduced binding to CRP.	Lysine	73-79	C-reactive protein, pentraxin-related	Mus musculus	167-170
35453416-1	2022	Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-kappaB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein for the Toll-like receptor (TLR) and interleukin (IL)-1beta receptor.	Lysine	206-212	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	151-194
14762086-2	2004	Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1.	Lysine	26-32	FAT atypical cadherin 1	Bos taurus	53-56
14762086-2	2004	Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1.	Lysine	26-32	diacylglycerol O-acyltransferase 1	Bos taurus	172-177
35453416-1	2022	Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-kappaB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein for the Toll-like receptor (TLR) and interleukin (IL)-1beta receptor.	Lysine	206-212	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	196-201
35121112-6	2022	Furthermore, we linked up the aberrant intragenic tri-methylation on H3 at lysine 4 (H3K4me3) and Ex-CGI DNA methylation in promoting transcription elongation of HOTAIR.	Lysine	75-81	HOX transcript antisense RNA	Homo sapiens	162-168
35383285-3	2022	Whereas acid stress triggers polymerisation of the E. coli lysine decarboxylase LdcI, such behaviour has not been observed for the arginine decarboxylase Adc.	Lysine	59-65	antizyme inhibitor 2	Homo sapiens	154-157
14593114-6	2004	In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys(48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase involved in protein degradation.	Lysine	118-121	ubiquitin conjugating enzyme E2 G2	Homo sapiens	52-56
35409359-2	2022	Herein, we developed a novel cationic cholesterol lipid derivative (CEL) in which cholesterol hydrophobic skeleton was connected to L-lysine cationic headgroup via a hexanediol linker as the non-viral siRNA delivery carrier.	Lysine	132-140	carboxyl ester lipase	Homo sapiens	68-71
14585837-6	2004	Introduction of only a Glu at position VII:06 and the removal of a neutralizing Lys residue at position VII:02 resulted in a 1000-fold increase in affinity of AMD3100 to within 10-fold of its affinity in CXCR4.	Lysine	80-83	C-X-C motif chemokine receptor 4	Homo sapiens	204-209
14594812-5	2004	Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDalpha1-Galpha binding, whereas mutation of the two flanking residues PLD(E563A) and PLD(F565A) decreased the binding.	Lysine	24-27	phospholipase D alpha 1	Arabidopsis thaliana	36-39
14594812-5	2004	Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDalpha1-Galpha binding, whereas mutation of the two flanking residues PLD(E563A) and PLD(F565A) decreased the binding.	Lysine	24-27	phospholipase D alpha 1	Arabidopsis thaliana	75-84
14594812-5	2004	Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDalpha1-Galpha binding, whereas mutation of the two flanking residues PLD(E563A) and PLD(F565A) decreased the binding.	Lysine	24-27	phospholipase D alpha 1	Arabidopsis thaliana	75-78
14594812-5	2004	Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDalpha1-Galpha binding, whereas mutation of the two flanking residues PLD(E563A) and PLD(F565A) decreased the binding.	Lysine	24-27	phospholipase D alpha 1	Arabidopsis thaliana	75-78
35202653-0	2022	Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer"s disease.	Lysine	0-6	microtubule associated protein tau	Homo sapiens	35-38
14731392-4	2004	The bromodomain protein Brd2 selectively interacted with acetylated lysine 12 on histone H4, whereas TAF(II)250 and PCAF recognized H3 and other acetylated histones, indicating fine specificity of histone recognition by different bromodomains.	Lysine	68-74	bromodomain containing 2	Homo sapiens	24-28
35255256-3	2022	Acetylation of the N-terminus and lysine side chains by N-succinimidyl acetate was selectively observed for intrinsically disordered alpha-synuclein and well-ordered ubiquitin.	Lysine	34-40	synuclein alpha	Homo sapiens	133-148
14527952-4	2003	Site-directed mutagenesis identified lysine 242 in the RD2 domain of human PLZF as the sumoylation site.	Lysine	37-43	zinc finger and BTB domain containing 16	Homo sapiens	75-79
14527952-6	2003	PLZF-mediated regulation of the cell cycle and transcriptional repression of the cyclin A2 gene were also dependent on sumoylation of PLZF on lysine 242.	Lysine	142-148	zinc finger and BTB domain containing 16	Homo sapiens	0-4
14527952-6	2003	PLZF-mediated regulation of the cell cycle and transcriptional repression of the cyclin A2 gene were also dependent on sumoylation of PLZF on lysine 242.	Lysine	142-148	zinc finger and BTB domain containing 16	Homo sapiens	134-138
35352207-2	2022	In healthy humans, oral administration of hArg increased the plasma concentration of Lys, suggesting Lys as a metabolite of hArg.	Lysine	85-88	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	42-46
14661947-6	2003	In contrast, while the histone H3 complex shows extensive interactions with tGcn5 and peptide residues N-terminal to the target lysine, the corresponding residues in histone H4 and p53 are disordered, suggesting that the N-terminal substrate region plays an important role in the enhanced affinity of the Gcn5/PCAF HAT proteins for histone H3.	Lysine	128-134	lysine acetyltransferase 2A	Homo sapiens	77-81
35352207-2	2022	In healthy humans, oral administration of hArg increased the plasma concentration of Lys, suggesting Lys as a metabolite of hArg.	Lysine	85-88	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	124-128
35352207-2	2022	In healthy humans, oral administration of hArg increased the plasma concentration of Lys, suggesting Lys as a metabolite of hArg.	Lysine	101-104	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	42-46
35352207-2	2022	In healthy humans, oral administration of hArg increased the plasma concentration of Lys, suggesting Lys as a metabolite of hArg.	Lysine	101-104	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	124-128
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Lysine	59-62	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	23-27
35352207-4	2022	In vitro, recombinant human arginase and bovine liver arginase I hydrolyzed hArg to Lys, suggesting Lys as a metabolite of hArg.	Lysine	100-103	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	76-80
14657036-6	2003	Overexpression of a degradation-resistant lysine-free Bim mutant in bim-/- cells abrogated the anti-apoptotic effect of M-CSF, while wild-type Bim did not.	Lysine	42-48	BCL2-like 11 (apoptosis facilitator)	Mus musculus	54-57
35352207-4	2022	In vitro, recombinant human arginase and bovine liver arginase I hydrolyzed hArg to Lys, suggesting Lys as a metabolite of hArg.	Lysine	100-103	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	123-127
14657036-6	2003	Overexpression of a degradation-resistant lysine-free Bim mutant in bim-/- cells abrogated the anti-apoptotic effect of M-CSF, while wild-type Bim did not.	Lysine	42-48	BCL2-like 11 (apoptosis facilitator)	Mus musculus	68-71
14657036-6	2003	Overexpression of a degradation-resistant lysine-free Bim mutant in bim-/- cells abrogated the anti-apoptotic effect of M-CSF, while wild-type Bim did not.	Lysine	42-48	colony stimulating factor 1 (macrophage)	Mus musculus	120-125
35352207-9	2022	Further analysis demonstrated that hArg and Lys are closely and specifically associated independently of experimental time/rat age and diet, suggesting that hArg and Lys are mutual metabolites in old rats.	Lysine	44-47	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	157-161
35352207-9	2022	Further analysis demonstrated that hArg and Lys are closely and specifically associated independently of experimental time/rat age and diet, suggesting that hArg and Lys are mutual metabolites in old rats.	Lysine	166-169	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	35-39
35352207-10	2022	Based on the plasma concentration changes, the median yield of hArg from Lys was determined to be 0.17% at T0 and each 0.27% at T2 and T4.	Lysine	73-76	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	63-67
14633995-7	2003	MDM2 shortened the half-life of both exogenous and endogenous p21waf1/cip1 by 50% and led to the degradation of its lysine-free mutant.	Lysine	116-122	MDM2 proto-oncogene	Homo sapiens	0-4
35352207-11	2022	With a circulating concentration of about 3 microM, hArg a major metabolite of Lys in healthy humans.	Lysine	79-82	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	52-56
35351852-0	2022	Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice.	Lysine	24-30	acyl-Coenzyme A oxidase 2, branched chain	Mus musculus	0-5
35351852-4	2022	Here we reported that non-histone lysine crotonylation (Kcr) levels were downregulated in Acox2-/- mice livers.	Lysine	34-40	acyl-Coenzyme A oxidase 2, branched chain	Mus musculus	90-95
35351142-14	2022	Furthermore, histone H4-Lys-20 monomethylation (H4K20me1), which is downstream of SETD8, was accompanied by ELK1 localization at the same promoter region of bach1.	Lysine	24-27	H4 clustered histone 6	Homo sapiens	13-23
35332266-8	2022	We confirmed that KAT6A acetylates lysine 23 of histone H3 (H3K23), and then enhances the association of the nuclear receptor binding protein TRIM24 and H3K23ac.	Lysine	35-41	lysine acetyltransferase 6A	Homo sapiens	18-23
15008512-4	2003	The docking results showed that compounds (4), (25) and (26) were bound to the active site of the enzyme Lys 295 of p60(c-Src) tyrosine kinase.	Lysine	105-108	sequestosome 1	Homo sapiens	116-119
35402258-6	2022	The second modification engineered in M7S was designed to enhance the stability of MDA-7 (IL-24), which was accomplished by replacing lysine at position K122 with arginine.	Lysine	134-140	interleukin 24	Homo sapiens	83-88
14580393-3	2003	Detroit 562 cells preferentially bound to Lys-plasminogen and this binding was inhibited in the presence of a lysine analog, epsilon-aminocaproic acid and by carboxypeptidase-B treatment suggesting that the C-terminal lysine residue of the putative pharyngeal cell receptor(s) may play an important role in plasminogen-binding.	Lysine	218-224	carboxypeptidase B1	Homo sapiens	158-176
14633678-3	2003	We now show that tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers.	Lysine	72-78	PR/SET domain 2	Homo sapiens	34-38
14633678-3	2003	We now show that tumor suppressor RIZ1 (PRDM2) methylates histone H3 on lysine 9, and this activity is reduced by mutations in the PR domain found in human cancers.	Lysine	72-78	PR/SET domain 2	Homo sapiens	40-45
35402258-6	2022	The second modification engineered in M7S was designed to enhance the stability of MDA-7 (IL-24), which was accomplished by replacing lysine at position K122 with arginine.	Lysine	134-140	interleukin 24	Homo sapiens	90-95
35331314-1	2022	Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis.	Lysine	85-91	lysine methyltransferase 2A	Homo sapiens	118-121
12882647-4	2003	This new calpain differs from calpain 3 in that it has lost IS1 insertion and exon 15, a lysine-rich sequence regarded as a nuclear translocation signal.	Lysine	89-95	calpain 3	Homo sapiens	30-39
35401699-2	2022	The only recognized function of DOT1L is histone H3 lysine 79 (H3K79) methylation, which has been implicated in both transcriptional activation and repression.	Lysine	52-58	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	32-37
14576281-0	2003	Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals.	Lysine	42-48	Saccharopine dehydrogenase	Arabidopsis thaliana	73-99
14576281-2	2003	To address this issue, we examined the effects of stress-related hormones, abscisic acid (ABA), and jasmonate, as well as various metabolic signals on the production of the mRNA and polypeptide of the bifunctional Lys-ketoglutarate reductase (LKR)/saccharopine dehydrogenase (SDH) enzyme, which contains the first two linked enzymes of Lys catabolism.	Lysine	214-217	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	243-246
14576281-2	2003	To address this issue, we examined the effects of stress-related hormones, abscisic acid (ABA), and jasmonate, as well as various metabolic signals on the production of the mRNA and polypeptide of the bifunctional Lys-ketoglutarate reductase (LKR)/saccharopine dehydrogenase (SDH) enzyme, which contains the first two linked enzymes of Lys catabolism.	Lysine	214-217	Saccharopine dehydrogenase	Arabidopsis thaliana	248-274
35322029-4	2022	Biochemical analysis reveals that RCOR1 associates with RNA Polymerase II (POL-II) during transcription and deacetylates its carboxy-terminal domain (CTD) at lysine 7.	Lysine	158-164	REST corepressor 1	Homo sapiens	34-39
14576281-2	2003	To address this issue, we examined the effects of stress-related hormones, abscisic acid (ABA), and jasmonate, as well as various metabolic signals on the production of the mRNA and polypeptide of the bifunctional Lys-ketoglutarate reductase (LKR)/saccharopine dehydrogenase (SDH) enzyme, which contains the first two linked enzymes of Lys catabolism.	Lysine	214-217	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	276-279
35330878-11	2022	Through the functional enrichment analysis of PLOD-related genes in PAAD, we found that PLODs were enriched in collagen fiber tissue structure, lysine degradation, and collagen biosynthesis.	Lysine	144-150	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	46-50
14550559-0	2003	Poly-L-lysine enhances the protein disaggregation activity of ClpB.	Lysine	0-13	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	62-66
14550559-2	2003	Unstructured polypeptides such as casein or poly-L-lysine have been shown to stimulate the ATPase activity of ClpB and thus may both act as substrates.	Lysine	44-57	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	110-114
14550559-3	2003	Here we compared the effects of alpha-casein and poly-L-lysine on the ATPase and chaperone activities of ClpB.	Lysine	49-62	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	105-109
14550559-5	2003	In contrast, poly-L-lysine stimulated exclusively the ATPase activity of the second AAA domain and increased the disaggregation activity of ClpB.	Lysine	13-26	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	140-144
12876293-3	2003	This role of Rtf1 resembles that of Rad6, which mediates ubiquitination of histone H2B at lysine 123.	Lysine	90-96	histone H2B	Saccharomyces cerevisiae S288C	75-86
35138101-4	2022	Here, we report light control of OGT activity in cells by replacing a catalytically essential lysine residue with a genetically encoded photocaged lysine.	Lysine	94-100	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	33-36
35138101-4	2022	Here, we report light control of OGT activity in cells by replacing a catalytically essential lysine residue with a genetically encoded photocaged lysine.	Lysine	147-153	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	33-36
12917457-5	2003	According to this model, VP1 is folded so that Lys-114 is in the beta E-beta F loop of the polypeptide chain at a considerable distance from Pro-240 and Trp-241 in the C-terminal region.	Lysine	47-50	all-trans retinoic acid induced differentiation factor	Homo sapiens	141-148
35328068-1	2022	KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation.	Lysine	88-94	lysine methyltransferase 2A	Homo sapiens	0-5
12878203-6	2003	Kinetic studies indicated that hK6 cleaved with much higher efficiency after Arg than Lys and with a preference for Ser or Pro in the P2 position.	Lysine	86-89	kallikrein related peptidase 6	Homo sapiens	31-34
35328068-1	2022	KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation.	Lysine	88-94	lysine methyltransferase 2A	Homo sapiens	7-34
35328068-1	2022	KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation.	Lysine	168-174	lysine methyltransferase 2A	Homo sapiens	0-5
35328068-1	2022	KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation.	Lysine	168-174	lysine methyltransferase 2A	Homo sapiens	7-34
34987057-7	2022	Loss of ARID1A in lung adenocarcinoma also resulted in loss of histone deacetylase 1 (HDAC1) recruitment, increasing acetylation of histone 4 lysine at the promoters of Pgam1, Pkm, and Pgk1 and subsequently enhancing BRD4-driven transcription of these genes.	Lysine	142-148	phosphoglycerate kinase 1	Homo sapiens	185-189
12874100-0	2003	Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.	Lysine	136-142	DIRAS family GTPase 3	Homo sapiens	54-58
35218667-8	2022	Depending on the RING domain, TRIM65 ubiquitinated and degraded the TPIT protein at multiple Lys sites.	Lysine	93-96	T-box 19	Mus musculus	68-72
12874100-5	2003	Chromatin immunoprecipitation assays revealed that histone H3 lysine 9/18 acetylation levels associated with ARHI in normal cells were significantly higher than those in breast cancer cell lines that lacked ARHI expression.	Lysine	62-68	DIRAS family GTPase 3	Homo sapiens	109-113
12874100-5	2003	Chromatin immunoprecipitation assays revealed that histone H3 lysine 9/18 acetylation levels associated with ARHI in normal cells were significantly higher than those in breast cancer cell lines that lacked ARHI expression.	Lysine	62-68	DIRAS family GTPase 3	Homo sapiens	207-211
35061896-4	2022	We found that topoisomerase 1-binding arginine/serine-rich protein (TOPORS) induces the SUMOylation of RAD51 at lysine residues 57 and 70 in response to DNA damaging agents.	Lysine	112-118	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	68-74
12926772-3	2003	This study investigated the effects of a nonconservative lysine to alanine (K232A) substitution in DGAT1, which very likely represents the causal mutation, on milk production traits.	Lysine	57-63	diacylglycerol O-acyltransferase 1	Bos taurus	99-104
12926772-7	2003	Effects of DGAT1 variants on content traits were pronounced; estimates of the gene substitution effect for the lysine-encoding variant were 0.35 and 0.28% for fat content and 0.10 and 0.06% for protein content in Fleckvieh and German Holstein, respectively.	Lysine	111-117	diacylglycerol O-acyltransferase 1	Bos taurus	11-16
12867036-5	2003	Here, we show that spSir2, the S. pombe Sir2-like protein that is the most closely related to the S. cerevisiae Sir2, is an NAD(+)-dependent deacetylase that efficiently deacetylates histone H3 lysine 9 (K9) and histone H4 lysine 16 (K16) in vitro.	Lysine	223-229	sirtuin 1	Homo sapiens	40-44
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	thioredoxin	Homo sapiens	42-45
12885341-4	2003	An A --&gt; T transversion in codon 29 of ICAM-1 exon 2 causes a lysine to methionine substitution (K29M), and was found at a high frequency (33.2%) in Kilifi (Kenya), as well as in other African populations.	Lysine	65-71	intercellular adhesion molecule 1	Homo sapiens	42-48
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	47-51
12758070-4	2003	We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13.	Lysine	56-62	Kruppel like factor 13	Homo sapiens	38-43
12758070-4	2003	We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13.	Lysine	56-62	Kruppel like factor 13	Homo sapiens	101-106
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	Lysine	92-95	NLR family, pyrin domain containing 3	Mus musculus	61-66
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	Lysine	92-95	NLR family, pyrin domain containing 3	Mus musculus	107-112
12704797-5	2003	In this communication, we report that the same concentrations of lysine-rich peptides or proteins that activate the holoenzyme cause strong inhibition of the phosphorylation of proteins catalyzed by the free catalytic CK2alpha subunit.	Lysine	65-71	casein kinase 2 alpha 2	Homo sapiens	218-226
35434453-2	2022	Trimethylation of lysine 27 of histone H3 at the cis-regulatory element of Hhex was maintained and that of lysine 4 was reduced during receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis, which was associated with a reduction of Hhex expression.	Lysine	18-24	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	187-192
35434453-2	2022	Trimethylation of lysine 27 of histone H3 at the cis-regulatory element of Hhex was maintained and that of lysine 4 was reduced during receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis, which was associated with a reduction of Hhex expression.	Lysine	107-113	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	187-192
35159030-3	2022	Heterochromatin protein 1 (HP1) recognizes histone H3 lysine 9 methylation and broadly affects chromatin biology, such as heterochromatin formation and maintenance, transcriptional regulation, DNA repair, chromatin remodeling, and chromosomal segregation.	Lysine	54-60	chromobox 5	Homo sapiens	0-25
12736296-9	2003	Since SET2 is also a histone methyltransferase, these results suggest a role for histone 3 lysine 36 methylation in transcriptional elongation.	Lysine	91-97	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	6-10
35159030-3	2022	Heterochromatin protein 1 (HP1) recognizes histone H3 lysine 9 methylation and broadly affects chromatin biology, such as heterochromatin formation and maintenance, transcriptional regulation, DNA repair, chromatin remodeling, and chromosomal segregation.	Lysine	54-60	chromobox 5	Homo sapiens	27-30
35172032-0	2022	Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis.	Lysine	94-100	LIF receptor alpha	Mus musculus	0-35
12595525-5	2003	The acetylation sites within CREB were mapped to three lysines within the CREB activation domain.	Lysine	55-62	cAMP responsive element binding protein 1	Homo sapiens	29-33
35095517-9	2021	In addition, the peptide containing lysine 239 was identified by mass spectrometry as the amoxicillin target sequence on alpha-enolase, thus suggesting a selective haptenation under our conditions.	Lysine	36-42	enolase 1	Homo sapiens	121-134
12595525-5	2003	The acetylation sites within CREB were mapped to three lysines within the CREB activation domain.	Lysine	55-62	cAMP responsive element binding protein 1	Homo sapiens	74-78
12595525-7	2003	Furthermore, these CREB lysine mutations do not increase interaction with the CRE or CBP.	Lysine	24-30	cAMP responsive element binding protein 1	Homo sapiens	19-23
12706348-10	2003	Taken together, these results suggest that the lysine-rich domains and conserved amino acid residues of p67 are involved in the regulation of eIF2alpha phosphorylation during heat shock.	Lysine	47-53	eukaryotic translation initiation factor 2A	Rattus norvegicus	142-151
2557345-3	1989	The arginine residue (Arg187) that is the presumed site of ADP-ribosylation of Gs alpha by cholera toxin has been changed to Ala, Glu, or Lys.	Lysine	138-141	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	79-87
12673594-6	2003	Modulation of keratinocyte adhesion by using poly-L-lysine coated cover slips resulted in an increased application of inhibitory beta1-antibodies and slightly reduced migration velocity and track formation.	Lysine	45-58	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	129-134
12642487-3	2003	HP1 associates with centric regions through an interaction with methylated lysine nine of histone H3, a modification generated by the histone methyltransferase SU(VAR)3-9.	Lysine	75-81	Suppressor of variegation 3-9	Drosophila melanogaster	160-170
12591926-6	2003	These results indicate that the assembly of a TRAF2 lysine 63-linked polyubiquitin chain by Ubc13/Uev1A is required for TNF-mediated GCKR and SAPK activation, but may not be required for ASK1 activation.	Lysine	52-58	TNF receptor associated factor 2	Homo sapiens	46-51
12735467-8	2003	The step-by-step modeling of hypothetical affinity pairs between t-PA and different types of oligo/polymer forms of linear and branched lysine derivatives obtained both by initiated polycondensation and solid-phase peptide synthesis using HPMDC seemed to be possible and a quite useful tool.	Lysine	136-142	chromosome 20 open reading frame 181	Homo sapiens	65-69
12706375-4	2003	In agreement with these findings, mutational analysis of the ETF/ETFDH genes demonstrated an ETFB missense mutation 124T&gt;C in exon 2 leading to replacement of cysteine-42 with arginine (C42R), and a 604_606AAG deletion in exon 6 in the ETFB gene resulting in the deletion of lysine-202 (K202del).	Lysine	278-284	electron transfer flavoprotein dehydrogenase	Homo sapiens	65-70
12706375-4	2003	In agreement with these findings, mutational analysis of the ETF/ETFDH genes demonstrated an ETFB missense mutation 124T&gt;C in exon 2 leading to replacement of cysteine-42 with arginine (C42R), and a 604_606AAG deletion in exon 6 in the ETFB gene resulting in the deletion of lysine-202 (K202del).	Lysine	278-284	electron transfer flavoprotein subunit beta	Homo sapiens	93-97
12529357-4	2003	The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor.	Lysine	47-50	epidermal growth factor	Gallus gallus	196-219
12511561-7	2003	Furthermore, we show that set2Delta ppr2Delta double mutants (PPR2 encodes TFIIS, a transcription elongation factor) are synthetically hypersensitive to 6-azauracil, and that deletions in the CTD reduce in vivo levels of H3 lysine 36 methylation.	Lysine	224-230	PPR2	Homo sapiens	62-66
12629047-2	2003	Although recent studies have shed light on a trans-histone regulatory pathway that controls H3 Lys 4 and H3 Lys 79 methylation in Saccharomyces cerevisiae, the regulatory pathway that affects Set2-mediated H3 Lys 36 methylation is unknown.	Lysine	95-98	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	192-196
12629047-2	2003	Although recent studies have shed light on a trans-histone regulatory pathway that controls H3 Lys 4 and H3 Lys 79 methylation in Saccharomyces cerevisiae, the regulatory pathway that affects Set2-mediated H3 Lys 36 methylation is unknown.	Lysine	108-111	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	192-196
12629047-2	2003	Although recent studies have shed light on a trans-histone regulatory pathway that controls H3 Lys 4 and H3 Lys 79 methylation in Saccharomyces cerevisiae, the regulatory pathway that affects Set2-mediated H3 Lys 36 methylation is unknown.	Lysine	108-111	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	192-196
12629047-6	2003	We further show that deletion of the RNA pol II C-terminal domain (CTD) kinase Ctk1, or partial deletion of the CTD, results in a selective abolishment of H3 Lys 36 methylation, implying a pathway of Set2 recruitment to chromatin and a role for H3 Lys 36 methylation in transcription elongation.	Lysine	158-161	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	79-83
12629047-6	2003	We further show that deletion of the RNA pol II C-terminal domain (CTD) kinase Ctk1, or partial deletion of the CTD, results in a selective abolishment of H3 Lys 36 methylation, implying a pathway of Set2 recruitment to chromatin and a role for H3 Lys 36 methylation in transcription elongation.	Lysine	248-251	cyclin-dependent serine/threonine protein kinase CTK1	Saccharomyces cerevisiae S288C	79-83
12590613-6	2003	Nardilysin also cleaves calcitonin at His-Arg and somatostatin-14 at Cys-Lys.	Lysine	73-76	somatostatin	Homo sapiens	50-65
12622383-1	2003	A series of glucose oxidase (GOx) hybrids (GOx-phe-nothiazine-labeled poly(ethylene oxide) (PT-PEO)) capable of direct electrical communication with electrodes is synthesized by covalently modifying PT-PEO to lysine residues on the enzyme surface.	Lysine	209-215	hydroxyacid oxidase 1	Homo sapiens	12-27
12622383-1	2003	A series of glucose oxidase (GOx) hybrids (GOx-phe-nothiazine-labeled poly(ethylene oxide) (PT-PEO)) capable of direct electrical communication with electrodes is synthesized by covalently modifying PT-PEO to lysine residues on the enzyme surface.	Lysine	209-215	hydroxyacid oxidase 1	Homo sapiens	29-32
12622383-1	2003	A series of glucose oxidase (GOx) hybrids (GOx-phe-nothiazine-labeled poly(ethylene oxide) (PT-PEO)) capable of direct electrical communication with electrodes is synthesized by covalently modifying PT-PEO to lysine residues on the enzyme surface.	Lysine	209-215	hydroxyacid oxidase 1	Homo sapiens	43-46
12622383-7	2003	In contrast, the i(cat) is almost constant for GOx-2-(10-phenothiazyl)propionic acid (PT-PA) hybrids with more than two PT groups synthesized by covalently modifying PT-PA to surface lysines, indicating that only a few key PT groups function as mediators.	Lysine	183-190	hydroxyacid oxidase 1	Homo sapiens	47-50
12581743-1	2003	Eukaryotic initiation factor 2 (eIF2)-associated glycoprotein, p67, has protection of eIF2alpha phosphorylation (POEP) activity, and this activity requires lysine-rich domains I and II of p67.	Lysine	156-162	eukaryotic translation initiation factor 2A	Homo sapiens	86-95
12540231-3	2003	Initial SAR together with molecular modeling and data from site-directed mutagenesis suggest an interaction of the phenethyl amide group with Lys-136.	Lysine	142-145	sarcosine dehydrogenase	Homo sapiens	8-11
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	206-209	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-128
12482974-2	2003	Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation directly correlates and histone H3 Lys-9 acetylation inversely correlates with DNA methylation in three neoplastic cell lines.	Lysine	206-209	O-6-methylguanine-DNA methyltransferase	Homo sapiens	135-139
12475234-13	2002	Altogether, our results designate Lys-277 as a likely candidate for nucleophilic attack of misacylated tRNA in the editing site of ValRS.	Lysine	34-37	valyl-tRNA synthetase 2, mitochondrial	Homo sapiens	131-136
12464276-2	2002	One of the prominent features of CaMKPase is stimulation of phosphatase activity by polycations such as poly-L-lysine (poly(Lys)).	Lysine	104-117	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	33-41
12464276-4	2002	Surface plasmon resonance (SPR) analysis showed that CaMKIV(T196D), which mimics CaMKPase substrate, and CaMKPase could form tight complexes with poly(Lys).	Lysine	151-155	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	81-89
12464276-4	2002	Surface plasmon resonance (SPR) analysis showed that CaMKIV(T196D), which mimics CaMKPase substrate, and CaMKPase could form tight complexes with poly(Lys).	Lysine	151-155	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	105-113
12464276-5	2002	Pull-down binding experiments suggested that the formation of a tightly associated ternary complex consisting of CaMKPase, poly(Lys), and phosphorylated CaMKIV is essential for stimulation.	Lysine	128-131	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	113-121
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Lysine	72-75	carboxypeptidase E	Mus musculus	12-15
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Lysine	72-75	carboxypeptidase D	Mus musculus	19-37
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Lysine	72-75	thyrotropin releasing hormone	Mus musculus	60-63
12446790-4	2002	TFIIB with the G204D mutation [TFIIB(G204D)] was suppressed by hydrophobic substitutions at lysine 239 of TBP.	Lysine	92-98	TATA-box binding protein	Homo sapiens	106-109
12205101-10	2002	From these studies, a structural basis for the profound differences in the substrate and inhibition kinetics of the wild-type 1 and 2 3beta-HSD, plus a catalytic role for the Tyr(154) and Lys(158) residues in the 3beta-HSD reaction have been identified.	Lysine	188-191	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	134-143
12205101-10	2002	From these studies, a structural basis for the profound differences in the substrate and inhibition kinetics of the wild-type 1 and 2 3beta-HSD, plus a catalytic role for the Tyr(154) and Lys(158) residues in the 3beta-HSD reaction have been identified.	Lysine	188-191	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	213-222
12419260-3	2002	We found that interactions of Bcl-2alpha with the mitochondrial import receptor Tom20 are dependent on two positively charged lysine residues in the immediate vicinity of the carboxy-terminal hydrophobic membrane anchor.	Lysine	126-132	Tom20p	Saccharomyces cerevisiae S288C	80-85
12379856-1	2002	The Sir3 protein helps form telomeric heterochromatin by interacting with hypoacetylated histone H4 lysine 16 (H4-Lys16).	Lysine	100-106	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	4-8
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18	Homo sapiens	46-51
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18	Homo sapiens	114-119
12381835-5	2002	IL-1F7b shares two conserved amino acids with IL-18 (Glu-35 and Lys-124), which participate in the interaction of IL-18 with the IL-18Ralpha chain as well as the IL-18-binding protein (IL-18BP), a secreted protein that neutralizes IL-18 activity.	Lysine	64-67	interleukin 18	Homo sapiens	114-119
12361401-7	2002	We find here that a Glu(32)-Lys(35) side chain to side chain covalent lactam constraint in hCRF and the corresponding Glu(31)-Lys(34) side chain to side chain covalent lactam constraint in sauvagine yield potent ligands that are selective for CRF(2).	Lysine	28-31	corticotropin releasing hormone receptor 2	Rattus norvegicus	243-248
12361401-7	2002	We find here that a Glu(32)-Lys(35) side chain to side chain covalent lactam constraint in hCRF and the corresponding Glu(31)-Lys(34) side chain to side chain covalent lactam constraint in sauvagine yield potent ligands that are selective for CRF(2).	Lysine	126-129	corticotropin releasing hormone receptor 2	Rattus norvegicus	243-248
12241545-4	2002	Herein, we first determined that PAPP-A cleaves IGFBP-4 at a single site (Met-135/Lys-136), and we analysed the influence of ionic strength, pH and zinc ion concentration on the cleavage reaction.	Lysine	82-85	insulin like growth factor binding protein 4	Homo sapiens	48-55
12242305-3	2002	Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional repression by recruiting histone methyltransferase.	Lysine	137-144	histone deacetylase 9	Homo sapiens	20-24
12242305-5	2002	Since the histone methyl-lysine residues recognized by HP1 also serve as substrates for deacetylation by HDACs, the interaction of MITR and HDACs with HP1 provides an efficient mechanism for silencing MEF2 target genes by coupling histone deacetylation and methylation.	Lysine	25-31	histone deacetylase 9	Homo sapiens	131-135
12110674-3	2002	A particular pair of HAT (Esa1) and HDAC (Rpd3) is proposed to modify the same lysine residue in vitro and in vivo.	Lysine	79-85	lysine acetyltransferase 5	Homo sapiens	26-30
12077425-5	2002	In ddm1 heterochromatin, DNA methylation is lost, and methylation of lysine 9 is largely replaced by methylation of lysine 4.	Lysine	69-75	chromatin remodeling 1	Arabidopsis thaliana	3-7
12077425-5	2002	In ddm1 heterochromatin, DNA methylation is lost, and methylation of lysine 9 is largely replaced by methylation of lysine 4.	Lysine	116-122	chromatin remodeling 1	Arabidopsis thaliana	3-7
12082110-6	2002	Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1.	Lysine	96-99	vitronectin	Homo sapiens	131-133
12169606-7	2002	These results, together with the observed recovery of the defect in VS production by the external addition of 3-hydroxypicolinic acid (3-HPA), a starter molecule in VS biosynthesis, suggest that VisA is the first enzyme of the VS biosynthetic pathway and that it supplies 3-HPA from L-lysine.	Lysine	283-291	mitochondrial antiviral signaling protein	Rattus norvegicus	195-199
12221124-9	2002	Last, we show that disruption of the functional interaction between endogenous FIP200 with FAK leads to increased FAK phosphorylation and partial restoration of cell cycle progression in cells plated on poly-L-lysine, providing further support for FIP200 as a negative regulator of FAK.	Lysine	203-216	RB1 inducible coiled-coil 1	Homo sapiens	79-85
12221124-9	2002	Last, we show that disruption of the functional interaction between endogenous FIP200 with FAK leads to increased FAK phosphorylation and partial restoration of cell cycle progression in cells plated on poly-L-lysine, providing further support for FIP200 as a negative regulator of FAK.	Lysine	203-216	RB1 inducible coiled-coil 1	Homo sapiens	248-254
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	77-104
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	106-109
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	35-41	Saccharopine dehydrogenase	Arabidopsis thaliana	115-141
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	35-41	Saccharopine dehydrogenase	Arabidopsis thaliana	143-146
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	210-217
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	43-46	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	77-104
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	43-46	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	106-109
12226495-1	2002	Both plants and animals catabolize lysine (Lys) via two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide encoded by a single LKR/SDH gene.	Lysine	43-46	Saccharopine dehydrogenase	Arabidopsis thaliana	115-141
12060666-6	2002	The Lys-731 sumoylation site is conserved in SRC-3 and SRC-1, and the NIDs of the latter coactivators harbor one or two additional sites matching with the consensus sites for SUMO-1 attachment, respectively, suggesting a more general role for the modification in the regulation of SRC protein activity.	Lysine	4-7	steroid receptor RNA activator 1	Homo sapiens	45-48
12070136-11	2002	Ubiquitination of histone H2B on lysine 123 is the signal for the methylation of histone H3, which leads to silencing of genes located near telomeres.	Lysine	33-39	histone H2B	Saccharomyces cerevisiae S288C	18-29
12176364-0	2002	A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.	Lysine	24-27	lymphocyte cytosolic protein 2	Homo sapiens	103-109
11988069-5	2002	Glutamic acid substitutions for two lysine residues in the activation loop of FAK, based upon the K650E (Lys(650--&gt;)Glu) mutant of fibroblast-growth-factor receptor 3, were made to create "SuperFAK".	Lysine	36-42	fibroblast growth factor receptor 3	Homo sapiens	134-169
11988069-5	2002	Glutamic acid substitutions for two lysine residues in the activation loop of FAK, based upon the K650E (Lys(650--&gt;)Glu) mutant of fibroblast-growth-factor receptor 3, were made to create "SuperFAK".	Lysine	105-108	fibroblast growth factor receptor 3	Homo sapiens	134-169
12196145-0	2002	Site-directed mutagenesis of Tyr-189 and Lys-193 in NADPH: protochlorophyllide oxidoreductase from Synechocystis.	Lysine	41-44	oxidoreductase	Escherichia coli	79-93
11970955-2	2002	HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN).	Lysine	33-36	vitronectin	Homo sapiens	162-173
11970955-2	2002	HKa and particularly its His-Gly-Lys-rich domain 5 have been previously reported to exert anti-adhesive properties by binding to the extracellular matrix protein vitronectin (VN).	Lysine	33-36	vitronectin	Homo sapiens	175-177
12056889-6	2002	NMR studies with these six single-site mutants reveal significant interactions of Lys 11 and Lys 29 with Glu 34 and Asp 21, respectively: pK(a) values for Glu 34 and Asp 21 increase by approximately 0.5-0.8 pH unit, similar to predicted values, when the lysines are replaced by neutral residues.	Lysine	254-261	beta-secretase 2	Homo sapiens	116-122
12056889-6	2002	NMR studies with these six single-site mutants reveal significant interactions of Lys 11 and Lys 29 with Glu 34 and Asp 21, respectively: pK(a) values for Glu 34 and Asp 21 increase by approximately 0.5-0.8 pH unit, similar to predicted values, when the lysines are replaced by neutral residues.	Lysine	254-261	beta-secretase 2	Homo sapiens	166-172
11927591-4	2002	Moreover, the truncated BRCA1*BARD1 complex exhibited efficient autoubiquitination activity in vitro capable of assembling non-lysine 48-linked polyubiquitin chains on both BRCA1-(1-639) and BARD1.	Lysine	127-133	BRCA1 DNA repair associated	Homo sapiens	24-29
11927591-4	2002	Moreover, the truncated BRCA1*BARD1 complex exhibited efficient autoubiquitination activity in vitro capable of assembling non-lysine 48-linked polyubiquitin chains on both BRCA1-(1-639) and BARD1.	Lysine	127-133	BRCA1 associated RING domain 1	Homo sapiens	30-35
11927591-4	2002	Moreover, the truncated BRCA1*BARD1 complex exhibited efficient autoubiquitination activity in vitro capable of assembling non-lysine 48-linked polyubiquitin chains on both BRCA1-(1-639) and BARD1.	Lysine	127-133	BRCA1 associated RING domain 1	Homo sapiens	191-196
11927591-6	2002	These results raise the possibility that BRCA1*BARD1 acts to assemble non-lysine 48-linked polyubiquitin chains that may serve as part of a signaling platform required for coordinating DNA repair-related events.	Lysine	74-80	BRCA1 DNA repair associated	Homo sapiens	41-46
11927591-6	2002	These results raise the possibility that BRCA1*BARD1 acts to assemble non-lysine 48-linked polyubiquitin chains that may serve as part of a signaling platform required for coordinating DNA repair-related events.	Lysine	74-80	BRCA1 associated RING domain 1	Homo sapiens	47-52
11919189-8	2002	This peripheral staining of ICAP-1alpha and nm23-H2 is only observed in cells spreading on fibronectin and collagen and is absent in cells spreading on poly-l-lysine, vitronectin, or laminin.	Lysine	152-165	integrin subunit beta 1 binding protein 1	Homo sapiens	28-39
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Lysine	170-176	histone H2B	Saccharomyces cerevisiae S288C	17-28
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Lysine	170-176	histone H2B	Saccharomyces cerevisiae S288C	104-115
12082171-6	2002	Mutational analysis revealed that both C-terminal lysine residues of Sip18p are essential for phospholipid-binding in vitro.	Lysine	50-56	Sip18p	Saccharomyces cerevisiae S288C	69-75
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Lysine	73-76	coagulation factor X	Homo sapiens	22-31
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Lysine	73-76	coagulation factor X	Homo sapiens	33-36
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Lysine	73-76	coagulation factor X	Homo sapiens	153-156
11861643-4	2002	Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.	Lysine	89-92	polyamine oxidase	Homo sapiens	13-30
11861643-4	2002	Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.	Lysine	89-92	monoamine oxidase B	Homo sapiens	165-170
11861643-4	2002	Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.	Lysine	132-135	polyamine oxidase	Homo sapiens	13-30
11861643-4	2002	Based on the polyamine oxidase three-dimensional crystal structure, it is suggested that Lys-305, Trp-397, and Tyr-407 in MAO A and Lys-296, Trp-388, and Tyr-398 in MAO B may be involved in the non-covalent binding to FAD.	Lysine	132-135	monoamine oxidase B	Homo sapiens	165-170
12068953-2	2002	Here we demonstrate a preferential interaction of HP1beta with the maternal genome immediately after fertilisation in the mouse zygote, which also shows a high level of lysine 9-methylated histone H3.	Lysine	169-175	chromobox 1	Mus musculus	50-57
12068953-4	2002	Paternal binding of HP1beta is only detected at the pronuclear stage, prior to the appearance of lysine 9-methylated histone H3.	Lysine	97-103	chromobox 1	Mus musculus	20-27
12653475-3	2002	AGE-chromophores accumulate on long-lived skin proteins such as collagen and elastin as a consequence of glycation, the spontaneous amino-carbonyl reaction of protein-bound lysine and arginine residues with reactive carbonyl species.	Lysine	173-179	elastin	Homo sapiens	77-84
11801607-6	2002	Prolonged incubation in the presence of LMB also leads to nuclear accumulation of IKK1, which was dependent on a lysine residue at position 44, which is also essential for kinase activity.	Lysine	113-119	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	82-86
11960383-1	2002	Mutation of four lysine residues in the p53 C-terminal domain inhibits MDM2-dependent ubiquitination of p53 and alters its subcellular distribution.	Lysine	17-23	MDM2 proto-oncogene	Homo sapiens	71-75
11714726-4	2002	Binding of H4 peptide (residues 1-34) acetylated at lysines Lys-5, Lys-8, Lys-12, and Lys-16 to an immobilized SIR3 protein fragment (residues 510-970) was investigated using surface plasmon resonance.	Lysine	52-59	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	111-115
11714726-5	2002	We find that acetylation of H4 lysines reduces binding (K(a)) of H4 to SIR3 in a cumulative manner so that the fully acetylated peptide binding is decreased approximately 50-fold relative to unacetylated peptide.	Lysine	31-38	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	71-75
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	6-13	activin A receptor type 1	Homo sapiens	133-156
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	15-18	activin A receptor type 1	Homo sapiens	133-156
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	24-27	activin A receptor type 1	Homo sapiens	133-156
11739381-6	2002	Three lysines, Lys-431, Lys-440, and Lys-441 in p50 were all acetylated in vitro, and a sequence similarity among p50, p53, Tat, and activin receptor type I on these particular lysines was observed.	Lysine	24-27	activin A receptor type 1	Homo sapiens	133-156
11835033-1	2002	BACKGROUND: Deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene is one of the mutations that causes hypertrophic cardiomyopathy (HCM).	Lysine	24-30	troponin I3, cardiac type	Homo sapiens	52-70
11835033-1	2002	BACKGROUND: Deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene is one of the mutations that causes hypertrophic cardiomyopathy (HCM).	Lysine	24-30	troponin I3, cardiac type	Homo sapiens	72-76
11799199-8	2002	The enzyme activity of the VP1 unique region showed typical Ca(2+) dependency and could be inhibited by manoalide and 4-bromophenacylbromide, which bind covalently to lysine and histidine residues, respectively, as part of the active center of the enzyme.	Lysine	167-173	capsid protein 1	Human parvovirus B19	27-30
11927133-1	2002	alpha(2)-Antiplasmin (alpha(2)AP) interferes with the binding of plasminogen to fibrin because lysine residues in its carboxy-terminal region compete with those in fibrin, presumably the same way that free lysine or epsilon-aminocaproic acid (EACA) inhibits plasminogen binding to fibrin.	Lysine	95-101	serpin family F member 2	Homo sapiens	0-20
11927133-1	2002	alpha(2)-Antiplasmin (alpha(2)AP) interferes with the binding of plasminogen to fibrin because lysine residues in its carboxy-terminal region compete with those in fibrin, presumably the same way that free lysine or epsilon-aminocaproic acid (EACA) inhibits plasminogen binding to fibrin.	Lysine	95-101	serpin family F member 2	Homo sapiens	22-32
11927133-1	2002	alpha(2)-Antiplasmin (alpha(2)AP) interferes with the binding of plasminogen to fibrin because lysine residues in its carboxy-terminal region compete with those in fibrin, presumably the same way that free lysine or epsilon-aminocaproic acid (EACA) inhibits plasminogen binding to fibrin.	Lysine	206-212	serpin family F member 2	Homo sapiens	0-20
11927133-1	2002	alpha(2)-Antiplasmin (alpha(2)AP) interferes with the binding of plasminogen to fibrin because lysine residues in its carboxy-terminal region compete with those in fibrin, presumably the same way that free lysine or epsilon-aminocaproic acid (EACA) inhibits plasminogen binding to fibrin.	Lysine	206-212	serpin family F member 2	Homo sapiens	22-32
11782425-4	2002	Transcrip tionally active phosphorylated CREB was also found in a rho0 143B human osteosarcoma cell line and in a MERRF cybrid cell line mutated for tRNA(Lys) (A8344G).	Lysine	154-157	cAMP responsive element binding protein 1	Homo sapiens	41-45
12392527-8	2002	The main enzyme cleavage sites were Lys-Trp, Val-Lys, Gly-Asp and Asp-Arg, as determined after incubation of P1 and P2 with the beta-chain of insulin.	Lysine	36-39	crystallin gamma F, pseudogene	Homo sapiens	109-118
12392527-8	2002	The main enzyme cleavage sites were Lys-Trp, Val-Lys, Gly-Asp and Asp-Arg, as determined after incubation of P1 and P2 with the beta-chain of insulin.	Lysine	49-52	crystallin gamma F, pseudogene	Homo sapiens	109-118
12785105-2	2002	Its soluble precursor (tropoelastin) has two major types of alternating domains: (1) hydrophilic cross-linked domains rich in Lys and Ala and (2) hydrophobic domains (responsible for elasticity) rich in Val, Pro, and Gly, which often occur in repeats of VPGVG or VGGVG.	Lysine	126-129	elastin	Homo sapiens	23-35
11756545-5	2002	In this report, we show that Smt3 conjugation occurs at a single site in Dorsal (lysine 382), requires just the Smt3-activating and -conjugating enzymes, and is reversed by the deconjugating enzyme Ulp1.	Lysine	81-87	smt3	Drosophila melanogaster	29-33
11742990-1	2001	The SET domain proteins, SUV39 and G9a have recently been shown to be histone methyltransferases specific for lysines 9 and 27 (G9a only) of histone 3 (H3).	Lysine	110-117	Suppressor of variegation 3-9	Drosophila melanogaster	25-30
11742990-1	2001	The SET domain proteins, SUV39 and G9a have recently been shown to be histone methyltransferases specific for lysines 9 and 27 (G9a only) of histone 3 (H3).	Lysine	110-117	G9a	Drosophila melanogaster	35-38
11742990-1	2001	The SET domain proteins, SUV39 and G9a have recently been shown to be histone methyltransferases specific for lysines 9 and 27 (G9a only) of histone 3 (H3).	Lysine	110-117	G9a	Drosophila melanogaster	128-131
11751634-2	2001	Recent studies have identified SET domain-containing proteins such as SUV39H1 and Clr4 as mediators of H3 lysine 9 (Lys9) methylation and heterochromatin formation.	Lysine	106-112	saccharopine dehydrogenase (NADP+, L-glutamate-forming)	Saccharomyces cerevisiae S288C	116-120
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Lysine	86-89	CD47 molecule	Homo sapiens	175-202
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Lysine	86-89	CD47 molecule	Homo sapiens	204-207
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Lysine	86-89	CD47 molecule	Homo sapiens	233-237
11493602-8	2001	GOLA and GALA formation from the Amadori product of glucose and lysine depends directly upon oxidation.	Lysine	64-70	galactosidase alpha	Homo sapiens	9-13
11689449-0	2001	A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.	Lysine	11-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
11691834-6	2001	In addition to the D box, efficient ubiquitination and degradation of SnoN also requires the Smad3 binding site in SnoN as well as key lysine residues necessary for ubiquitin attachment.	Lysine	135-141	SKI like proto-oncogene	Homo sapiens	70-74
11691834-7	2001	Mutation of either the Smad3 binding site or lysine residues results in stabilization of SnoN and in enhanced antagonism of TGF-beta signaling.	Lysine	45-51	SKI like proto-oncogene	Homo sapiens	89-93
11892848-2	2001	The N-terminal domain of histone H4 contains four acetylation sites at lysine residues and may play a separate role in chromatin structure from the remainder of the H4 chain.	Lysine	71-77	H4 clustered histone 9	Homo sapiens	25-35
11583571-0	2001	Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.	Lysine	74-80	coactosin like F-actin binding protein 1	Homo sapiens	0-22
11583571-9	2001	Site-directed mutagenesis revealed the involvement of Lys(75) of CLP in actin binding, a residue highly conserved in related proteins and supposed to be exposed on the surface of the CLP protein.	Lysine	54-57	coactosin like F-actin binding protein 1	Homo sapiens	65-68
11583571-9	2001	Site-directed mutagenesis revealed the involvement of Lys(75) of CLP in actin binding, a residue highly conserved in related proteins and supposed to be exposed on the surface of the CLP protein.	Lysine	54-57	coactosin like F-actin binding protein 1	Homo sapiens	183-186
11583571-10	2001	Our results identify CLP as a new human protein that binds F-actin in vitro and in vivo, and indicate that Lys(75) is essential for this interaction.	Lysine	107-110	coactosin like F-actin binding protein 1	Homo sapiens	21-24
11601924-8	2001	The amino acids 109 Phe and 122 Glu in NS3 of CH1392 were substituted by Ile and Lys, respectively, in T1P1.	Lysine	81-84	KRAS proto-oncogene, GTPase	Homo sapiens	39-42
11585801-5	2001	Mutation of this amino acid to lysine changes the inductive abilities of VegT and Eomesodermin to resemble that of Xbra.	Lysine	31-37	vegt protein S homeolog	Xenopus laevis	73-77
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Lysine	105-111	replication factor C subunit 1	Saccharomyces cerevisiae S288C	137-141
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Lysine	105-111	replication factor C subunit 2	Saccharomyces cerevisiae S288C	143-147
11384967-4	2001	Tat lysines 50 and 51, target of acetylation by p300/CBP, were also found to be acetylated by hGCN5.	Lysine	4-11	lysine acetyltransferase 2A	Homo sapiens	94-99
11384967-5	2001	The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat.	Lysine	29-36	Tat	Human immunodeficiency virus 1	86-89
11384967-5	2001	The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat.	Lysine	29-36	lysine acetyltransferase 2A	Homo sapiens	151-156
11384967-5	2001	The acetylation of these two lysines by p300/CBP has been recently shown to stimulate Tat transcriptional activity and accordingly, we have found that hGCN5 can considerably enhance Tat-dependent transcription of the HIV-1 long terminal repeat.	Lysine	29-36	Tat	Human immunodeficiency virus 1	182-185
11384967-6	2001	These data highlight the importance of the acetylation of lysines 50 and 51 in the function of Tat, since different histone acetyltransferases involved in distinct signaling pathways, GCN5 and p300/CBP, converge to acetylate Tat on the same site.	Lysine	58-65	lysine acetyltransferase 2A	Homo sapiens	184-188
11432991-5	2001	pH gating is driven by protonation of an intracellular lysine residue (K80 in K(ir)1.1).	Lysine	55-61	potassium inwardly-rectifying channel, subfamily J, member 1	Rattus norvegicus	78-86
12084985-4	2001	Microbeads coated with MK or poly-L-lysine induced clustering of glypican-2 as well as syndecan-3.	Lysine	29-42	syndecan 3	Mus musculus	87-97
11442827-8	2001	Carboxypeptidase B treatment and amino acid substitutions of the C-terminal lysyl residues of Eno indicated that the C-terminal lysine is pivotal for plasmin(ogen)-binding activity.	Lysine	128-134	carboxypeptidase B1	Homo sapiens	0-18
11150296-0	2001	Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.	Lysine	9-15	signal transducer and activator of transcription 1	Homo sapiens	92-97
11150296-6	2001	In the three-dimensional structure of STAT1, we observed a structural arginine/lysine-rich element within the DNA-binding domain of the molecule.	Lysine	79-85	signal transducer and activator of transcription 1	Homo sapiens	38-43
11379758-6	2001	PHBP cleaved the C-terminal side of Arg in the peptide effectively and that of Lys weakly.	Lysine	79-82	hyaluronan binding protein 2	Homo sapiens	0-4
11294634-2	2001	Cationic interfacial binding residues of A. p. piscivorus PLA(2) (Lys-10) and human group IIa PLA(2) (Arg-7, Lys-10, and Lys-16), which mediate electrostatic interactions with anionic membranes, primarily accelerate the membrane association.	Lysine	66-69	phospholipase A2 group IIA	Homo sapiens	58-64
11294634-2	2001	Cationic interfacial binding residues of A. p. piscivorus PLA(2) (Lys-10) and human group IIa PLA(2) (Arg-7, Lys-10, and Lys-16), which mediate electrostatic interactions with anionic membranes, primarily accelerate the membrane association.	Lysine	109-112	phospholipase A2 group IIA	Homo sapiens	94-100
11294634-2	2001	Cationic interfacial binding residues of A. p. piscivorus PLA(2) (Lys-10) and human group IIa PLA(2) (Arg-7, Lys-10, and Lys-16), which mediate electrostatic interactions with anionic membranes, primarily accelerate the membrane association.	Lysine	109-112	phospholipase A2 group IIA	Homo sapiens	94-100
11114306-1	2001	The cationic amino acid transporter, Cat-1, facilitates the uptake of the essential amino acids arginine and lysine.	Lysine	109-115	solute carrier family 7 member 1	Homo sapiens	37-42
11264579-5	2001	The 4"-aldehyde of the PLP cofactor is covalently linked to the epsilon-amino group of the active-site lysine, Lys202, via a Schiff-base linkage in two of the structures.	Lysine	103-109	proteolipid protein 1	Homo sapiens	23-26
11242054-0	2001	Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.	Lysine	36-42	Heterochromatin Protein 1c	Drosophila melanogaster	66-69
11242054-6	2001	Here we show that HP1 can bind with high affinity to histone H3 methylated at lysine 9 but not at lysine 4.	Lysine	78-84	Heterochromatin Protein 1c	Drosophila melanogaster	18-21
11242054-6	2001	Here we show that HP1 can bind with high affinity to histone H3 methylated at lysine 9 but not at lysine 4.	Lysine	98-104	Heterochromatin Protein 1c	Drosophila melanogaster	18-21
11242054-7	2001	The chromo domain of HP1 is identified as its methyl-lysine-binding domain.	Lysine	53-59	Heterochromatin Protein 1c	Drosophila melanogaster	21-24
11160680-6	2001	This mutant encodes a v-Abl protein in which the beta B5 arginine at the base of the phosphotyrosine-binding pocket has been replaced by a lysine.	Lysine	139-145	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	22-27
11978968-5	2001	Besides the PPIase motif, PPIL4 also has an RNA recognition motif (RRM), a pair of bipartite nuclear targeting sequences, and a lysine rich domain.	Lysine	128-134	peptidylprolyl isomerase like 4	Homo sapiens	26-31
10948191-0	2000	An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.	Lysine	10-13	adrenoceptor alpha 2A	Homo sapiens	72-100
10948191-12	2000	Unlike previously described variants of G-protein-coupled receptors, where the minor species causes either a loss of function or increased non-agonist function, Lys-251 alpha(2A)AR represents a new class of polymorphism whose phenotype is a gain of agonist-promoted function.	Lysine	161-164	adrenoceptor alpha 2A	Homo sapiens	169-180
11098085-1	2000	Deoxyhypusine synthase is the key enzyme for modifying a lysine residue to hypusine in the cellular protein eukaryotic initiation factor 5A (eIF-5A).	Lysine	57-63	eukaryotic translation initiation factor 5A2	Mus musculus	108-139
11098085-1	2000	Deoxyhypusine synthase is the key enzyme for modifying a lysine residue to hypusine in the cellular protein eukaryotic initiation factor 5A (eIF-5A).	Lysine	57-63	eukaryotic translation initiation factor 5A2	Mus musculus	141-147
11063591-8	2000	Residues Val-1, Arg-7, and Lys-9 of V1 peptide were found to be critical for receptor interaction, because single alanine replacement at these positions dramatically decreased peptide binding to CXCR4.	Lysine	27-30	C-X-C motif chemokine receptor 4	Homo sapiens	195-200
11063596-0	2000	pH dependence of formation of a partially unfolded state of a Lys 73 --&gt; His variant of iso-1-cytochrome c: implications for the alkaline conformational transition of cytochrome c.	Lysine	62-65	eukaryotic translation initiation factor 1	Homo sapiens	91-96
11063596-1	2000	The alkaline conformational transition of a lysine 73 --&gt; histidine variant of iso-1-cytochrome c has been studied.	Lysine	44-50	eukaryotic translation initiation factor 1	Homo sapiens	82-87
11087338-1	2000	The amino acid homopolymers, poly-L-lysine and poly-L-ornithine, have been modified by the covalent attachment of palmitoyl and methoxypoly(ethylene glycol) (mPEG) residues to produce a new class of amphiphilic polymers-PLP and POP, respectively.	Lysine	29-42	proteolipid protein 1	Homo sapiens	220-223
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Lysine	96-99	carboxypeptidase B1	Homo sapiens	115-118
10900194-7	2000	The A and B beta-strands of the N-terminal domain of TIMP-3 contain two potential heparin-binding sequences rich in lysine and arginine; these strands should form a double track on the outer surface of TIMP-3.	Lysine	116-122	TIMP metallopeptidase inhibitor 3	Homo sapiens	53-59
2513889-0	1989	The active site composition of porcine pancreatic lipase: possible involvement of lysine.	Lysine	82-88	pancreatic lipase	Homo sapiens	39-56
2513889-1	1989	A mechanism is proposed wherein an essential lysine in porcine pancreatic lipase is the acylable residue in the catalytic mechanism of the enzyme.	Lysine	45-51	pancreatic lipase	Homo sapiens	63-80
2576856-3	1989	The binding of calcium and the activation are modified by treatment with NBD-Cl and with PLP suggesting the presence of cysteine and lysine residues at the high affinity binding sites.	Lysine	133-139	proteolipid protein 1	Homo sapiens	89-92
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Lysine	102-105	tryptase	Canis lupus familiaris	48-56
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Lysine	245-248	tryptase	Canis lupus familiaris	48-56
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Lysine	245-248	tryptase	Canis lupus familiaris	209-217
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Lysine	245-248	tryptase	Canis lupus familiaris	209-217
2552437-5	1989	In contrast, the KRAS protein, which carries an extremely basic domain (residues 172-182, Lys-Asp-Glu-Lys6-Ser-Arg), is phosphorylated by the receptor kinase without the addition of basic proteins.	Lysine	90-93	KRAS proto-oncogene, GTPase	Homo sapiens	17-21
2768256-11	1989	Based on known tropoelastin sequences and the molecular weights of the discrete fragments, additional fragmentation of protropoelastin and/or tropoelastin most likely occurs at the lysine/alanine-enriched domains presumably involved in cross-link formation.	Lysine	181-187	elastin	Rattus norvegicus	122-134
2527237-4	1989	Antibody was produced against the annexin consensus peptide, Lys-Ala-Met-Lys-Gly-Leu-Gly-Thr-Asp-Glu, which was derived from the sequence of several Ca2+/phospholipid-binding proteins including calpactin, lipocortin, endonexin II, 67-kDa calelectrin, lymphocyte 68-kDa protein, and protein II.	Lysine	61-64	annexin A5	Rattus norvegicus	217-229
2569467-12	1989	This novel posttranslational modification may represent an important alteration of EF-1 alpha, comparable to the regulatory effects of posttranslational methylation of EF-1 alpha lysine residues.	Lysine	179-185	eukaryotic translation initiation factor 1A	Mus musculus	168-178
2526127-5	1989	The augmented fibrin binding of rt-PA is partially abolished when the plasmin-degraded fibrin matrices are subsequently treated with carboxypeptidase B, demonstrating that this increased binding is dependent on the generation of carboxyl-terminal lysine residues in the fibrin matrix.	Lysine	247-253	carboxypeptidase B1	Homo sapiens	133-151
2473157-6	1989	The encoded amino acid sequence of ECP shows 66% identity to that of EDN and 31% identity to that of human pancreatic ribonuclease, including conservation of the essential structural cysteine and cataytic lysine and histidine residues.	Lysine	205-211	ribonuclease A family member 3	Homo sapiens	35-38
11075928-5	2000	It causes a change at position 1682 of glutamate into lysine and results in a tenfold drop in adenylate cyclase activity.	Lysine	54-60	adenylate cyclase	Saccharomyces cerevisiae S288C	94-111
2552329-4	1989	In accordance, increases in intracellular cyclic GMP by sodium nitroprusside and EDRF were attenuated by LY 83583.	Lysine	105-107	5'-nucleotidase, cytosolic II	Homo sapiens	49-52
10987925-4	2000	Treatment of Boc-protected L-lysine (6) under the latter conditions afforded hydroxylamine 7 in excellent yield.	Lysine	27-35	BOC cell adhesion associated, oncogene regulated	Homo sapiens	13-16
2508254-5	1989	Three different treatments of citrated plasma samples (acidification/reneutralization, addition of 5 mM EDTA or of 0.5 M lysine) prior to determination by ELISA all resulted in increased tPA levels.	Lysine	121-127	chromosome 20 open reading frame 181	Homo sapiens	187-190
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Lysine	203-209	coagulation factor X	Homo sapiens	146-155
10878019-7	2000	As Glu-89 in RGS16 is interacting with Lys-210 in Galpha(i1), this lysine was changed to glutamate for compensation.	Lysine	39-42	protein phosphatase 1, regulatory (inhibitor) subunit 1A	Rattus norvegicus	50-59
10878019-7	2000	As Glu-89 in RGS16 is interacting with Lys-210 in Galpha(i1), this lysine was changed to glutamate for compensation.	Lysine	67-73	protein phosphatase 1, regulatory (inhibitor) subunit 1A	Rattus norvegicus	50-59
2925609-7	1989	HSP86 was found to contain internal peptide repeats of Glu-Lys-Glu within a region of highly charged amino acid residues.	Lysine	59-62	heat shock protein 90, alpha (cytosolic), class A member 1	Mus musculus	0-5
10978155-8	2000	Glutamate 61 of flavodoxin is identified as a cross-linked residue, and lysine 959 of the C-terminal activation domain of methionine synthase is assigned as its partner.	Lysine	72-78	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	122-141
2466334-3	1989	The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues.	Lysine	104-110	amphiregulin	Homo sapiens	27-39
10859319-6	2000	NH(2)-terminal amino acid sequencing revealed that MMP-12 cleaved TFPI at Lys(20)-Leu(21)(close to Kunitz I domain and producing a 35-kDa band), Arg(83)-Ile(84) (between Kunitz I and II domains), and Ser(174)-Thr(175) (between Kunitz II and III domains).	Lysine	74-77	matrix metallopeptidase 12	Homo sapiens	51-57
10859319-7	2000	MMP-7 and MMP-9 cleaved TFPI at Lys(20)-Leu(21) with additional COOH-terminal processing.	Lysine	32-35	matrix metallopeptidase 9	Homo sapiens	10-15
2913947-3	1989	Comparison of the amino acid sequence of rat tropoelastin to four other tropoelastin species reveals that the hydrophobic peptide repeat regions in the middle of each molecule and the crosslinking areas containing three lysine residues are remarkably conserved.	Lysine	220-226	elastin	Rattus norvegicus	45-57
10833508-9	2000	The insensitive Kir3.2 was made sensitive to BDNF by adding a tyrosine (D41Y) and a lysine (P32K) upstream to generate a phosphorylation site motif analogous to that present in Kir3.4.	Lysine	84-90	brain derived neurotrophic factor	Homo sapiens	45-49
10825173-5	2000	Furthermore, binding between tropoelastin and fibrillin was mediated by ionic interactions involving the lysine side chains of tropoelastin.	Lysine	105-111	elastin	Homo sapiens	29-41
10825173-5	2000	Furthermore, binding between tropoelastin and fibrillin was mediated by ionic interactions involving the lysine side chains of tropoelastin.	Lysine	105-111	elastin	Homo sapiens	127-139
2913947-5	1989	In addition, the COOH-terminal sequence of the rat tropoelastin is virtually identical to tropoelastins of other species in possessing a cysteine/arginine/lysine containing segment.	Lysine	155-161	elastin	Rattus norvegicus	51-63
2919891-0	1989	[Activation of neutrophil function by MDP-Lys(L 18)].	Lysine	42-45	ribosomal protein L18	Homo sapiens	46-50
10807912-8	2000	Degradation is independent of the single Lys residue of the protein; a lysine-less mutant LMP1 is degraded in a ubiquitin- and proteasome-dependent manner similar to the wild type protein.	Lysine	41-44	PDZ and LIM domain 7	Homo sapiens	90-94
2919891-1	1989	The study was carried out to confirm the effect of MDP-Lys (L 18) on the neutrophil number and function in the patients with lung cancer.	Lysine	55-58	ribosomal protein L18	Homo sapiens	60-64
10807912-8	2000	Degradation is independent of the single Lys residue of the protein; a lysine-less mutant LMP1 is degraded in a ubiquitin- and proteasome-dependent manner similar to the wild type protein.	Lysine	71-77	PDZ and LIM domain 7	Homo sapiens	90-94
3238648-9	1988	Intact positively charged lysines on factor Xa may also be important.	Lysine	26-33	coagulation factor X	Homo sapiens	37-46
10807912-9	2000	Degradation of both wild type and lysine-less protein is sensitive to fusion of a Myc tag to the N terminus of LMP1.	Lysine	34-40	PDZ and LIM domain 7	Homo sapiens	111-115
3197840-5	1988	Amino acid sequencing shows that pepsinogen A3 has Glu at position 43, whereas pepsinogen A5 has Lys.	Lysine	97-100	pepsinogen A5	Homo sapiens	79-92
10864652-6	2000	In addition, both in vitro and in vivo experiments indicate that E6AP self-ubiquitination results primarily from an intramolecular transfer of ubiquitin from the active-site cysteine to one or more lysine residues; however, intermolecular transfer can also occur in the context of an E6-mediated E6AP multimer.	Lysine	198-204	ubiquitin protein ligase E3A	Homo sapiens	65-69
2848032-1	1988	Lysine 32 has been previously implicated by chemical modification and modeling studies as a key component of the domain which controls recognition and binding of cytochrome c to its physiological partners, e.g. cytochrome b2, cytochrome c peroxidase, and cytochrome oxidase.	Lysine	0-6	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	226-273
10929113-1	2000	Both plants and animals catabolize lysine via saccharopine by two consecutive enzymes, lysine-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	87-117
10929113-1	2000	Both plants and animals catabolize lysine via saccharopine by two consecutive enzymes, lysine-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	119-122
10929113-1	2000	Both plants and animals catabolize lysine via saccharopine by two consecutive enzymes, lysine-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide.	Lysine	35-41	Saccharopine dehydrogenase	Arabidopsis thaliana	128-154
10929113-1	2000	Both plants and animals catabolize lysine via saccharopine by two consecutive enzymes, lysine-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single polypeptide.	Lysine	35-41	Saccharopine dehydrogenase	Arabidopsis thaliana	156-159
10929113-8	2000	Not all plant species possess an active monofunctional SDH gene and the production of this enzyme is correlated with an increased flux of lysine catabolism.	Lysine	138-144	Saccharopine dehydrogenase	Arabidopsis thaliana	55-58
10929113-9	2000	Taken together, our results suggest that the composite LKR/SDH locus serves to control an efficient, highly regulated flux of lysine catabolism	Lysine	126-132	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	55-62
10748065-3	2000	The lumenal domain of triadin contains multiple repeats of alternating lysine and glutamic acid residues, which have been defined as KEKE motifs and have been proposed to promote protein associations.	Lysine	71-77	triadin	Homo sapiens	22-29
2849540-5	1988	An enzyme in which lysine-205 had been mutated to threonine was produced and found to have no G6PD activity, proving that this lysine residue is essential for enzyme activity in human G6PD.	Lysine	19-25	glucose-6-phosphate dehydrogenase	Homo sapiens	184-188
10748065-6	2000	Alanine mutagenesis within this motif demonstrated that the critical amino acids of triadin binding to calsequestrin are the even-numbered residues Lys(210), Lys(212), Glu(214), Lys(216), Gly(218), Gln(220), Lys(222), and Lys(224).	Lysine	148-151	triadin	Homo sapiens	84-91
3231516-0	1988	Restorative effect of MDP-Lys (L18) on leukopenia of cancer patient treated with radiotherapy.	Lysine	26-29	immunoglobulin kappa variable 1-13	Homo sapiens	31-34
10748065-6	2000	Alanine mutagenesis within this motif demonstrated that the critical amino acids of triadin binding to calsequestrin are the even-numbered residues Lys(210), Lys(212), Glu(214), Lys(216), Gly(218), Gln(220), Lys(222), and Lys(224).	Lysine	158-161	triadin	Homo sapiens	84-91
10748065-6	2000	Alanine mutagenesis within this motif demonstrated that the critical amino acids of triadin binding to calsequestrin are the even-numbered residues Lys(210), Lys(212), Glu(214), Lys(216), Gly(218), Gln(220), Lys(222), and Lys(224).	Lysine	158-161	triadin	Homo sapiens	84-91
10775527-11	2000	On the basis of these and other results, we propose that AASS catalyzes the first two steps of the major lysine-degradation pathway in human cells and that inactivating mutations in the AASS gene are a cause of hyperlysinemia.	Lysine	105-111	aminoadipate-semialdehyde synthase	Homo sapiens	57-61
10775527-11	2000	On the basis of these and other results, we propose that AASS catalyzes the first two steps of the major lysine-degradation pathway in human cells and that inactivating mutations in the AASS gene are a cause of hyperlysinemia.	Lysine	105-111	aminoadipate-semialdehyde synthase	Homo sapiens	186-190
3334852-7	1988	These data suggest that the amino residue of Lys-10 and the carboxylic acid of Lys-26 in peptide T-11 play crucial roles in the ionic binding of alpha 2-plasmin inhibitor to the tranexamic acid-binding site (lysine-binding site) of plasminogen.	Lysine	45-48	serpin family F member 2	Homo sapiens	145-170
10825373-5	2000	The NK(2) receptor-selective antagonist, SR48968, produced concentration-related rightward shift in the log concentration curve to [Lys(5), MeLeu(9), Nle(10)]NKA(4-10).	Lysine	132-135	tachykinin receptor 2	Homo sapiens	4-18
10702277-7	2000	In addition, binding of OBA to the active site of PTP1B creates a unique arrangement involving Asp(181), Lys(120), and Tyr(46).	Lysine	105-108	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	50-55
3334852-7	1988	These data suggest that the amino residue of Lys-10 and the carboxylic acid of Lys-26 in peptide T-11 play crucial roles in the ionic binding of alpha 2-plasmin inhibitor to the tranexamic acid-binding site (lysine-binding site) of plasminogen.	Lysine	79-82	serpin family F member 2	Homo sapiens	145-170
3334852-7	1988	These data suggest that the amino residue of Lys-10 and the carboxylic acid of Lys-26 in peptide T-11 play crucial roles in the ionic binding of alpha 2-plasmin inhibitor to the tranexamic acid-binding site (lysine-binding site) of plasminogen.	Lysine	208-214	serpin family F member 2	Homo sapiens	145-170
2448969-3	1987	Virus growth was enhanced by treatment with silica but not by treatment with anti-asialo GM1 serum in MDP-Lys (L18)-treated mice.	Lysine	106-109	ribosomal protein L18	Mus musculus	111-114
10677492-5	2000	This analysis indicated that when single amino acid residues in a region close to the luminal face of the putative transmembrane domain of Ost4p were changed into an ionizable amino acid such as Lys or Asp, growth at 37 degrees C and OT activity measured in vitro were impaired.	Lysine	195-198	olichyl-diphosphooligosaccharide--protein glycotransferase OST4	Saccharomyces cerevisiae S288C	139-144
2448969-5	1987	Excess interferon production in MDP-Lys (L18)-treated mice was seen on day 1 but not on days 2 to 7 of the infection.	Lysine	36-39	ribosomal protein L18	Mus musculus	41-44
2448969-6	1987	The possible role of macrophages and interferon in providing non-specific protection against Sendai virus in the MDP-Lys (L18)-treated mice is discussed.	Lysine	117-120	ribosomal protein L18	Mus musculus	122-125
10672029-10	2000	P1" Pro, Asp, Lys and Gly slowed the hydrolysis rates of the tomato LAP-A, porcine LAP, and E. coli PepA markedly.	Lysine	14-17	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	68-73
10672029-10	2000	P1" Pro, Asp, Lys and Gly slowed the hydrolysis rates of the tomato LAP-A, porcine LAP, and E. coli PepA markedly.	Lysine	14-17	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	68-71
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Lysine	201-204	tenascin	Oryctolagus cuniculus	136-139
10640303-3	2000	Constitutive activity could be enhanced more by both mutation of Thr(373) of the alpha(2A)-AR to a Lys and Cys(351) of the G(alphao) protein by an Ile.	Lysine	99-102	adrenoceptor alpha 2A	Homo sapiens	81-93
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	72-75	motilin	Homo sapiens	26-36
11030087-8	2000	Best activity was shown against hCA I and bCA IV, for which some of the new compounds (such as the Lys, Arg, His or the dipeptide derivatives) showed affinities in the 2-12 nm range (h = human; b = bovine isozymes).	Lysine	99-102	carbonic anhydrase 1	Homo sapiens	32-37
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	72-75	motilin	Homo sapiens	29-36
10600387-3	1999	In vitro, Hpa2 is able to acetylate specific lysine residues of histones H3 and H4 with a preference for Lys14 of histone H3.	Lysine	45-51	histone acetyltransferase	Saccharomyces cerevisiae S288C	10-14
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	76-79	motilin	Homo sapiens	26-36
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	76-79	motilin	Homo sapiens	29-36
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	76-79	motilin	Homo sapiens	26-36
3666144-4	1987	Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues.	Lysine	76-79	motilin	Homo sapiens	29-36
2821651-1	1987	Plasminogen kringle 1+2+3 (K1-3) containing lysine-binding sites inhibited the reaction of plasmin with alpha 2-plasmin inhibitor (alpha 2PI), in a rate assay using a synthetic chromogenic substrate, S-2251.	Lysine	44-50	serpin family F member 2	Homo sapiens	104-129
2821651-1	1987	Plasminogen kringle 1+2+3 (K1-3) containing lysine-binding sites inhibited the reaction of plasmin with alpha 2-plasmin inhibitor (alpha 2PI), in a rate assay using a synthetic chromogenic substrate, S-2251.	Lysine	44-50	serpin family F member 2	Homo sapiens	131-140
10561465-9	1999	Mutagenesis of Lys 40 significantly decreased, but did not eliminate cleavage, suggesting that there are additional secondary sites of cleavage in the ST6Gal I stem.	Lysine	15-18	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	151-159
2821651-3	1987	These results suggest that K1-3 blocked the binding of alpha 2PI to the lysine-binding site of plasmin.	Lysine	72-78	serpin family F member 2	Homo sapiens	55-64
2821651-8	1987	The above findings indicate that the reaction of alpha 2PI with the lysine-binding site of plasmin is involved in the inhibition of plasmin activity by alpha 2PI, and in the presence of an inhibitor of this reaction, the balance of coagulofibrinolytic activity in plasma will be shifted towards the fibrinolytic side.	Lysine	68-74	serpin family F member 2	Homo sapiens	49-58
2821651-8	1987	The above findings indicate that the reaction of alpha 2PI with the lysine-binding site of plasmin is involved in the inhibition of plasmin activity by alpha 2PI, and in the presence of an inhibitor of this reaction, the balance of coagulofibrinolytic activity in plasma will be shifted towards the fibrinolytic side.	Lysine	68-74	serpin family F member 2	Homo sapiens	152-161
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Lysine	285-288	peroxiredoxin 3	Homo sapiens	222-227
10559333-4	1999	In addition, we showed that Rep1 and Rep2 proteins hydrolyze ATP, and by changing the key lysine residue in the proteins" nucleoside triphosphate binding sites, demonstrated that this ATPase activity is essential for multiplication of virus DNA in vivo.	Lysine	90-96	CHM Rab escort protein	Homo sapiens	28-32
10579719-6	1999	We have identified four major SUMO attachment-site lysine residues in Cdc3, one in Cdc11, and two in Shs1, all within the consensus sequence (IVL)KX(ED).	Lysine	51-57	septin CDC3	Saccharomyces cerevisiae S288C	70-74
3030433-4	1987	By comparison with the shifts reported for lysine-13-modified cytochrome c we conclude that the results reported here support the Poulos-Kraut proposed structure for the molecular redox complex between cytochrome-c peroxidase and cytochrome c.	Lysine	43-49	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	202-225
10563822-7	1999	We propose that the transition from the high-spin to the low-spin form of the protein occurs by deprotonation and ligation to the heme of the B10 tyrosine oxygen, facilitated by strong interaction with the E10 lysine side chain.	Lysine	210-216	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	142-145
3030433-5	1987	These results indicate that the principal site of interaction with cytochrome-c peroxidase is the exposed heme edge of horse cytochrome c, in proximity to lysine-13 and the heme pyrrole II.	Lysine	155-161	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	67-90
10564829-12	1999	As in all motilin precursors already sequenced (man, monkey, pig and rabbit), an endoproteinase cleavage site is present at Lys(23)-Lys(24).	Lysine	124-127	motilin	Homo sapiens	10-17
3494701-10	1987	There is a polymer effect with respect to the rate constant of the slow process: 2k8 = 4.8 X 10(7) dm3 mol-1 s-1 (H2B) and 2k8 = 4 X 10(8) dm3 mol-1 s-1 (Lys-Tyr-Lys, Prutz et al.	Lysine	154-157	histone H2B type 2-E	Bos taurus	114-117
10564829-12	1999	As in all motilin precursors already sequenced (man, monkey, pig and rabbit), an endoproteinase cleavage site is present at Lys(23)-Lys(24).	Lysine	132-135	motilin	Homo sapiens	10-17
10542236-2	1999	Deoxyhypusine synthase catalyzes the formation of a deoxyhypusine residue in the translation eukaryotic initiation factor 5A (eIF5A) precursor protein by transferring an aminobutyl moiety from spermidine onto a conserved lysine residue within the eIF5A polypeptide chain.	Lysine	221-227	deoxyhypusine synthase	Nicotiana tabacum	0-22
3100332-0	1987	Sequence identity between a lysine-containing peptide from Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase and an active site peptide from human erythrocyte glucose-6-phosphate dehydrogenase.	Lysine	28-34	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
10608664-7	1999	Steady-state levels of DHPS mRNA were slightly reduced in the endosperms and embryos of the maize lysine-rich opaque2 mutants when compared with those in normal kernels.	Lysine	98-104	regulatory protein opaque-2	Zea mays	110-117
3540604-7	1986	At base pair +683 a G-to-A transition was detected in the ADR1 coding sequence which would result in the substitution of a lysine residue for an arginine at amino acid 228.	Lysine	123-129	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	58-62
10497213-6	1999	Mutation of any one of the HAH1p C-terminal Lys residues (Lys(56), Lys(57), or Lys(60)) to Gly does not affect the interaction, although deletion of the 15 C-terminal residues abolishes the interaction.	Lysine	44-47	antioxidant 1 copper chaperone	Homo sapiens	27-32
10497213-6	1999	Mutation of any one of the HAH1p C-terminal Lys residues (Lys(56), Lys(57), or Lys(60)) to Gly does not affect the interaction, although deletion of the 15 C-terminal residues abolishes the interaction.	Lysine	58-61	antioxidant 1 copper chaperone	Homo sapiens	27-32
3529091-6	1986	In contrast, no processing was observed in the absence of a spacer peptide in the insulin precursor molecule, e.g., B-Lys-Arg-A (where A and B are the A and B chain of human proinsulin, respectively).	Lysine	118-121	N-acetylglutamate synthase	Homo sapiens	122-127
10473582-1	1999	Identification of critical lysine residues in DbpA required for decorin binding.	Lysine	27-33	Y box protein 3	Mus musculus	46-50
10473582-6	1999	Of the 27 lysine residues in native DbpA from strain 297, 6 are present in most and 5 are conserved in all 30 DbpA sequences examined so far.	Lysine	10-16	Y box protein 3	Mus musculus	36-40
10473582-6	1999	Of the 27 lysine residues in native DbpA from strain 297, 6 are present in most and 5 are conserved in all 30 DbpA sequences examined so far.	Lysine	10-16	Y box protein 3	Mus musculus	110-114
10473582-7	1999	Analysis of recombinant DbpA in which individual lysine residues have been mutated to alanine suggested that three of the conserved residues distributed throughout the DbpA sequence are required for decorin binding.	Lysine	49-55	Y box protein 3	Mus musculus	24-28
10473582-10	1999	We conclude that the three lysine residues Lys-82, Lys-163, and Lys-170 are crucial for the binding of DbpA to decorin.	Lysine	27-33	Y box protein 3	Mus musculus	103-107
10473582-10	1999	We conclude that the three lysine residues Lys-82, Lys-163, and Lys-170 are crucial for the binding of DbpA to decorin.	Lysine	43-46	Y box protein 3	Mus musculus	103-107
10473582-10	1999	We conclude that the three lysine residues Lys-82, Lys-163, and Lys-170 are crucial for the binding of DbpA to decorin.	Lysine	51-54	Y box protein 3	Mus musculus	103-107
10473582-10	1999	We conclude that the three lysine residues Lys-82, Lys-163, and Lys-170 are crucial for the binding of DbpA to decorin.	Lysine	51-54	Y box protein 3	Mus musculus	103-107
10485994-6	1999	hCAT-1 cRNA injection into Xenopus laevis oocytes stimulated saturable lysine uptake (K(m) approximately 100 microM).	Lysine	71-77	solute carrier family 7 member 1	Homo sapiens	0-6
10525449-1	1999	A new peptide carrier with three-dimensional predetermined structural motif has been constructed by the repetitive Lys-Aib-Gly moiety.	Lysine	115-118	ANIB1	Homo sapiens	119-122
10224118-0	1999	Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.	Lysine	0-6	vitamin D receptor	Homo sapiens	18-36
10224118-7	1999	These results indicate that the lysine 246 participates, together with residues in helix 12, in the recruitment of coactivators and that AF-2 activity is involved both in ligand-dependent transactivation and in transrepression by VDR.	Lysine	32-38	vitamin D receptor	Homo sapiens	230-233
10340621-3	1999	A primary ion-dipole interaction between the terminal P2 side chain group and lysine 60G is evoked to explain the SAR in this series.	Lysine	78-84	sarcosine dehydrogenase	Homo sapiens	114-117
10215892-0	1999	Contribution of a prosegment lysine residue to the function and structure of porcine pepsinogen A and its active form pepsin A.	Lysine	29-35	pepsinogen A5	Homo sapiens	118-126
10087463-6	1999	Replacement of Ser5 with the negatively charged Glu also decreased the binding affinity, but substitution with the positively charged Lys substantially increased the affinity of [Nle10] NKA(4-10) for the NK-2 receptor.	Lysine	134-137	tachykinin receptor 2	Rattus norvegicus	204-217
10085225-4	1999	According to this model, the membrane domain of Fur4p contains three charged amino acid residues (Glu-243, Lys-272 and Glu-539) that are conserved in the members of the FUR family of yeast transporters.	Lysine	107-110	uracil permease	Saccharomyces cerevisiae S288C	48-53
10082538-5	1999	Mutation of lysine residue 798 in the DNA-dependent ATPase domain of BRG1 significantly reduced its ability to repress c-fos transcription.	Lysine	12-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-124
10221692-4	1999	Genetic analysis revealed a single nucleotide substitution on exon 4 in the hormone-binding domain of the androgen receptor (AR) gene, resulting in a change of codon 681 GAG (glutamic acid) to AAG (lysine).	Lysine	198-204	N-methylpurine DNA glycosylase	Homo sapiens	193-196
10069383-5	1999	The mutant enzyme in which double mutations Lys-33 to Ala and Thr-34 to Ala were introduced, fully lost both of these activities, indicating that Lys-33 and/or Thr-34 are important for both ATPase and deoxyribonuclease activities.	Lysine	44-47	ATPase	Escherichia coli	190-196
9933646-9	1999	Nonetheless, a subtle role in TIMP-2 interaction for the 566/567/568-lysine triad is indicated from the enhanced reduction in TIMP-2 binding that occurs when mutations here were combined with K617A.	Lysine	69-75	TIMP metallopeptidase inhibitor 2	Homo sapiens	126-132
10022501-4	1999	These findings suggest that the LOXL protein (possibly an isoform of lysyl oxidase) is involved in the development of lysine-derived cross-links in collagenous substrates.	Lysine	118-124	lysyl oxidase-like 1	Mus musculus	32-36
9891069-8	1999	We further observed that the HPK1 mutant HPK1-KD(M46), which encodes the kinase domain with a point mutation at lysine-46, and HPK1-PR blocked interleukin-2 (IL-2) induction in Jurkat T cells, suggesting that HPK1 signaling plays a critical role in IL-2 induction.	Lysine	112-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	29-33
9891069-8	1999	We further observed that the HPK1 mutant HPK1-KD(M46), which encodes the kinase domain with a point mutation at lysine-46, and HPK1-PR blocked interleukin-2 (IL-2) induction in Jurkat T cells, suggesting that HPK1 signaling plays a critical role in IL-2 induction.	Lysine	112-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	41-45
9891069-8	1999	We further observed that the HPK1 mutant HPK1-KD(M46), which encodes the kinase domain with a point mutation at lysine-46, and HPK1-PR blocked interleukin-2 (IL-2) induction in Jurkat T cells, suggesting that HPK1 signaling plays a critical role in IL-2 induction.	Lysine	112-118	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	41-45
9890950-6	1999	Mutations of the putative invariant lysine in Cak1p (Lys-31), homologous to a residue required for activity in virtually all protein kinases and that interacts with the ATP phosphates, moderately reduced the ability of Cak1p to bind ATP but did not dramatically affect the catalytic rate of the kinase.	Lysine	36-42	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	46-51
9890950-6	1999	Mutations of the putative invariant lysine in Cak1p (Lys-31), homologous to a residue required for activity in virtually all protein kinases and that interacts with the ATP phosphates, moderately reduced the ability of Cak1p to bind ATP but did not dramatically affect the catalytic rate of the kinase.	Lysine	36-42	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	219-224
9890950-6	1999	Mutations of the putative invariant lysine in Cak1p (Lys-31), homologous to a residue required for activity in virtually all protein kinases and that interacts with the ATP phosphates, moderately reduced the ability of Cak1p to bind ATP but did not dramatically affect the catalytic rate of the kinase.	Lysine	53-56	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	46-51
9890950-6	1999	Mutations of the putative invariant lysine in Cak1p (Lys-31), homologous to a residue required for activity in virtually all protein kinases and that interacts with the ATP phosphates, moderately reduced the ability of Cak1p to bind ATP but did not dramatically affect the catalytic rate of the kinase.	Lysine	53-56	cyclin-dependent protein kinase-activating kinase CAK1	Saccharomyces cerevisiae S288C	219-224
9928950-5	1999	Our results suggest that a basic lysine residue at the -2 position from the cleavage site is required for cathepsin B cleavage of prorenin in vitro and that the structure of prorenin itself may account for the selection of the proper cleavage site.	Lysine	33-39	cathepsin B	Homo sapiens	106-117
9915770-5	1999	The covalent complexes are likely a result of isopeptide bond formation between lysine 193 of TnI and glutamine 191 of TnT by the cross-linking enzyme transglutaminase.	Lysine	80-86	troponin T3, fast skeletal type	Rattus norvegicus	119-122
10090430-3	1999	Eptifibatide (Integrilin) is a cyclic heptapeptide inhibitor that contains a modified lysine-glycine-aspartic acid sequence that recognizes the binding site of platelet GP IIb-IIIa, resulting in potent and selective inhibition of its binding to fibrinogen.	Lysine	86-92	integrin subunit alpha 2b	Homo sapiens	169-175
10082226-6	1999	A preferential CCK(B) receptor antagonists LY 288,513 at a high dose (4 mg/kg) blocked the action of CCK-4, but not that of caerulein.	Lysine	43-45	cholecystokinin B receptor	Mus musculus	15-30
10082226-6	1999	A preferential CCK(B) receptor antagonists LY 288,513 at a high dose (4 mg/kg) blocked the action of CCK-4, but not that of caerulein.	Lysine	43-45	cholecystokinin	Mus musculus	15-18
9830048-6	1998	Within this region, two adjacent lysine residues were identified that were critical for synaptotagmin oligomerization, AP-2, and synprint binding.	Lysine	33-39	transcription factor AP-2 alpha	Homo sapiens	119-123
10096020-0	1998	Tip60 acetylates six lysines of a specific class in core histones in vitro.	Lysine	21-28	lysine acetyltransferase 5	Homo sapiens	0-5
10096020-2	1998	Since the acetylation of core histones at particular lysines mediates distinct effects on chromatin assembly and gene regulation, the identification of lysine site specificity of the HAT activity of Tip60 is an initial step in the analysis of its molecular function.	Lysine	53-60	lysine acetyltransferase 5	Homo sapiens	199-204
10096020-2	1998	Since the acetylation of core histones at particular lysines mediates distinct effects on chromatin assembly and gene regulation, the identification of lysine site specificity of the HAT activity of Tip60 is an initial step in the analysis of its molecular function.	Lysine	53-59	lysine acetyltransferase 5	Homo sapiens	199-204
10096020-4	1998	Preferred acetylation sites for Tip60 are the Lys-5 of histone H2A, the Lys-14 of histone H3, and the Lys-5, -8, -12, -16 of histone H4, determined by a method which combined matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) measurements and Lys-C endopeptidase digestion, or a method detecting the incorporation of radiolabelled acetate into synthetic peptides.	Lysine	46-49	lysine acetyltransferase 5	Homo sapiens	32-37
10096020-5	1998	CONCLUSION: The lysine site specificity of Tip60 in histone amino-terminal tail peptides in vitro has been characterized by an assay measuring the molecular mass of endopeptidase digested peptides, or a previously described assay.	Lysine	16-22	lysine acetyltransferase 5	Homo sapiens	43-48
9822691-4	1998	hIIa-PLA2 contains 13 lysines, 2 histidines, and 10 arginines that fall into 10 clusters.	Lysine	22-29	phospholipase A2 group IIA	Homo sapiens	5-9
9771895-2	1998	In addition, class III alcohol dehydrogenase, identical to glutathione-dependent formaldehyde dehydrogenase, was mutated at position 115, introducing Ser or Lys.	Lysine	157-160	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
9722562-8	1998	The total usage of glutamine and lysine residues in vitro by TGase 3 was similar to that seen in earlier in vivo studies.	Lysine	33-39	transglutaminase 3	Homo sapiens	61-68
9761476-9	1998	We find that L-NTP interacts with rK1, rK2, K4, and K5-all lysine-binding kringles-in a fashion that closely mimics what has been observed for the Glul-HSer57 N-terminal fragment of Pgn (CB-NTP).	Lysine	59-65	keratin 1	Rattus norvegicus	34-37
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	Rac family small GTPase 1	Homo sapiens	86-90
9705280-10	1998	Mutation of these Lys residues to neutral residues decreased PAK binding to activated Rac1 and Rac2 (but not Cdc42) and greatly reduced PAK1 activation by Rac1, Rac2, and Cdc42 proteins in vivo.	Lysine	18-21	Rac family small GTPase 1	Homo sapiens	155-159
9753390-2	1998	The importance of the residues located near the Arg-Lys dibasic site in the C-terminal region of the pro-hormone for the cleavage of the precursor into somatostatin-14 has been confirmed.	Lysine	52-55	somatostatin	Homo sapiens	152-167
9601073-3	1998	Two-dimensional 1H-13C NMR spectroscopy of the complexes formed by the derivatized cytochromes with cytochrome b5 and cytochrome c peroxidase has been used to investigate the number and identity of lysine residues of cytochrome c that are involved in interprotein interactions of cytochrome c. The NMR data are incompatible with simple static models proposed previously for the complexes formed by these proteins, but are consistent with the presence of multiple, interconverting complexes of comparable stability, consistent with studies employing Brownian dynamics to model the complexes.	Lysine	198-204	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	118-141
9647635-4	1998	Each gene encodes a complete ORF with no less than 86% amino acid sequence identity to human RNase k6 with the eight cysteines and catalytic histidines (H15 and H123) and lysine (K38) typically observed among members of the RNase A superfamily.	Lysine	171-177	ribonuclease A family member k6	Homo sapiens	93-101
9575181-7	1998	Significantly, expression of a RICK mutant in which the lysine of the putative ATP-binding site at position 38 was replaced by a methionine functioned as an inhibitor of CD95-mediated apoptosis.	Lysine	56-62	receptor interacting serine/threonine kinase 2	Homo sapiens	31-35
9575209-3	1998	Site-directed mutagenesis on two of these residues, Tyr-92 and Lys-278, in the tomato isoenzyme Le-ACS2 greatly reduces enzymatic activity, indicating their importance in catalysis.	Lysine	63-66	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	99-103
9588954-4	1998	On the other hand, the Lys-Arg bond (position 3-4) was found to be susceptible only to gamma-NGF.	Lysine	23-26	kallikrein 1-related peptidase b3	Mus musculus	87-96
9521691-5	1998	Acetoacetylation of 74% of lysine residues and cyclohexanedione modification of 54% of arginine residues completely abolished the interactions between LDL and MTP.	Lysine	27-33	microsomal triglyceride transfer protein	Homo sapiens	159-162
9521691-6	1998	Regeneration of lysine and arginine residues by hydroxylamine treatment completely restored the binding of modified LDL to MTP.	Lysine	16-22	microsomal triglyceride transfer protein	Homo sapiens	123-126
9521691-9	1998	Furthermore, modification of lysine and arginine, but not the aspartic and glutamic acid, residues in apoB18 also completely abolished its interactions with MTP.	Lysine	29-35	microsomal triglyceride transfer protein	Homo sapiens	157-160
9521691-10	1998	These studies indicated that lysine and arginine, but not aspartic and glutamic acid, residues are critical for apoB-MTP interactions, whereas histidine residues are not as critical.	Lysine	29-35	microsomal triglyceride transfer protein	Homo sapiens	117-120
9497395-11	1998	Competition experiments with poly-L-arginine, poly-L-lysine, and protamine reveal that yNAP-1 binds to core and linker histones more tightly despite the much higher positive charge densities of the former molecules.	Lysine	46-59	histone chaperone NAP1	Saccharomyces cerevisiae S288C	87-93
9521659-3	1998	Kex2 exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1 (Lys-Arg or Arg-Arg cleavage sites).	Lysine	54-57	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Lysine	71-74	transforming growth factor beta induced	Homo sapiens	223-233
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Lysine	71-74	transforming growth factor beta induced	Homo sapiens	306-316
9615731-5	1998	Another was located on codon 174 and replaced AGG (Arg) with AAG (Lys).	Lysine	66-69	N-methylpurine DNA glycosylase	Homo sapiens	61-64
9540798-6	1998	These assays showed that chymotrypsin and elastase cleave pNiXa at the P1-P1 (Thr-Lys) peptide bond near the C-terminus, while trypsin and cathepsin G cleave pNiXa at specific peptide bonds near the N-terminus, within an interesting 26-residue segment, rich in Lys and Gln, that separates the His-cluster of pNiXa from the rest of the molecule.	Lysine	261-264	cathepsin G	Bos taurus	139-150
9430722-5	1998	In contrast, mutation of the highly conserved lysine residues in the carboxyl terminus of HAH1 had no effect on copper trafficking to the secretory pathway but eliminated the antioxidant function of HAH1 in sod1 delta yeast.	Lysine	46-52	antioxidant 1 copper chaperone	Homo sapiens	90-94
9430722-5	1998	In contrast, mutation of the highly conserved lysine residues in the carboxyl terminus of HAH1 had no effect on copper trafficking to the secretory pathway but eliminated the antioxidant function of HAH1 in sod1 delta yeast.	Lysine	46-52	antioxidant 1 copper chaperone	Homo sapiens	199-203
9430731-7	1998	Substitutions of the lysine residues conserved among DRBD sequences block association of GCN2 with ribosomes and impaired the ability of the kinase to stimulate translational control in response to amino acid limitation.	Lysine	21-27	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	89-93
9425086-15	1998	In addition, 14-3-3 zeta bound with lower affinity to a peptide based on the central region of the GP Ibalpha cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibbeta (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 zeta with comparable affinity to the GHSL-containing peptide.	Lysine	246-249	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	13-24
9537673-2	1998	In the Ang II receptor type AT2, this Lysine residue is conserved at position 215 in the fifth transmembrane domain.	Lysine	38-44	angiotensin II receptor type 2 L homeolog	Xenopus laevis	28-31
9537673-8	1998	These results suggest that the binding mechanism of 125I-[Sar1-Ile8]Ang II to AT2 receptor is similar to that of AT1 receptor since an amino acid with positively charged side chain (Lys or Arg) located in the fifth transmembrane domain is required for this ligand to bind AT2 receptor.	Lysine	182-185	angiotensin II receptor type 2 L homeolog	Xenopus laevis	78-81
9537673-8	1998	These results suggest that the binding mechanism of 125I-[Sar1-Ile8]Ang II to AT2 receptor is similar to that of AT1 receptor since an amino acid with positively charged side chain (Lys or Arg) located in the fifth transmembrane domain is required for this ligand to bind AT2 receptor.	Lysine	182-185	angiotensin II receptor type 2 L homeolog	Xenopus laevis	272-275
9469585-3	1998	Site-directed mutagenesis was used to generate mutant constructs of LCAT in which glutamic acid residues 154, 155, and 165 were replaced with glutamine or lysine.	Lysine	155-161	lecithin-cholesterol acyltransferase	Homo sapiens	68-72
10806846-4	1998	Additionally, Lys, Val, Leu and Ala were also found very rich in HSP70 of all origins.	Lysine	14-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	65-70
9459510-4	1998	Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80.	Lysine	36-39	major histocompatibility complex, class I, C	Homo sapiens	80-85
9426595-1	1997	We isolated the gene encoding lysine-ketoglutarate reductase (LKR, EC 1.5.1.8) and saccharopine dehydrogenase (SDH, ED 1.5.1.9) from an Arabidopsis thaliana genomic DNA library based on the homology between the yeast biosynthetic genes encoding SDH (lysine-forming) or SDH (glutamate-forming) and Arabidopsis expressed sequence tags.	Lysine	30-36	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	62-65
9426595-1	1997	We isolated the gene encoding lysine-ketoglutarate reductase (LKR, EC 1.5.1.8) and saccharopine dehydrogenase (SDH, ED 1.5.1.9) from an Arabidopsis thaliana genomic DNA library based on the homology between the yeast biosynthetic genes encoding SDH (lysine-forming) or SDH (glutamate-forming) and Arabidopsis expressed sequence tags.	Lysine	30-36	Saccharopine dehydrogenase	Arabidopsis thaliana	245-248
9426595-1	1997	We isolated the gene encoding lysine-ketoglutarate reductase (LKR, EC 1.5.1.8) and saccharopine dehydrogenase (SDH, ED 1.5.1.9) from an Arabidopsis thaliana genomic DNA library based on the homology between the yeast biosynthetic genes encoding SDH (lysine-forming) or SDH (glutamate-forming) and Arabidopsis expressed sequence tags.	Lysine	30-36	Saccharopine dehydrogenase	Arabidopsis thaliana	245-248
9426595-3	1997	DNA sequencing revealed that the gene encodes a bifunctional protein with an amino domain homologous to SDH (lysine-forming), thus corresponding to LKR, and a carboxy domain homologous to SDH (glutamate-forming).	Lysine	109-115	Saccharopine dehydrogenase	Arabidopsis thaliana	104-107
9426595-3	1997	DNA sequencing revealed that the gene encodes a bifunctional protein with an amino domain homologous to SDH (lysine-forming), thus corresponding to LKR, and a carboxy domain homologous to SDH (glutamate-forming).	Lysine	109-115	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	148-151
9370448-0	1997	Spin-label electron spin resonance studies on the interactions of lysine peptides with phospholipid membranes.	Lysine	66-72	spindlin 1	Homo sapiens	20-24
9370448-1	1997	The interactions of lysine oligopeptides with dimyristoyl phosphatidylglycerol (DMPG) bilayer membranes were studied using spin-labeled lipids and electron spin resonance spectroscopy.	Lysine	20-26	spindlin 1	Homo sapiens	123-127
9370448-1	1997	The interactions of lysine oligopeptides with dimyristoyl phosphatidylglycerol (DMPG) bilayer membranes were studied using spin-labeled lipids and electron spin resonance spectroscopy.	Lysine	20-26	spindlin 1	Homo sapiens	156-160
9370448-4	1997	In DMPG and dimyristoylphosphatidylserine host membranes, the perturbation of the lipid chain mobility by polylysine was greater for negatively charged spin-labeled lipids than for zwitterionic lipids, but for the shorter lysine peptides these differences were smaller.	Lysine	110-116	spindlin 1	Homo sapiens	152-156
9370448-6	1997	Surface binding of the basic lysine peptides strongly reduced the interfacial pK of spin-labeled fatty acid incorporated into the DMPG bilayers, to a greater extent for polylysine than for tetralysine or pentalysine at saturation.	Lysine	29-35	spindlin 1	Homo sapiens	84-88
9359434-0	1997	Characterization of chicken-liver glutathione S-transferase (GST) A1-1 and A2-2 isoenzymes and their site-directed mutants heterologously expressed in Escherichia coli: identification of Lys-15 and Ser-208 on cGSTA1-1 as residues interacting with ethacrynic acid.	Lysine	187-190	ATPase H+ transporting V0 subunit a2	Gallus gallus	75-79
3017908-1	1986	Viral oncogene product of avian sarcoma virus S2 was reported to have two alterations from proto-src product; a substitution of its extreme carboxyl terminus with a peptide of helper viral protein and a point mutation which altered the 501st amino acid from arginine to lysine.	Lysine	270-276	p60 src	Rous sarcoma virus	97-100
9325342-6	1997	Radiosequencing of [125I]AZIK-labeled rVMAT2 indicated derivatization of Lys-20 in the NH2 terminus, just prior to putative transmembrane domain 1 (TMD1).	Lysine	73-76	solute carrier family 18 member A2	Rattus norvegicus	38-44
3017908-4	1986	Rous sarcoma virus and S1, another isolate which had transduced proto-src, also coded for lysine at the same position.	Lysine	90-96	p60 src	Rous sarcoma virus	70-73
9375793-2	1997	The longest ORF of the cDNA predicts a lysine-rich small polypeptide identical to the rat RPL38 protein (100% identity), and sharing a 84% of identity to the tomato RPL38 protein sequence.	Lysine	39-45	ribosomal protein L38	Rattus norvegicus	90-95
3632209-3	1986	Lysine and tryptophan values for the Pajimaca Opaque-2 almost doubled those determined in the normal variety Pajimaca.	Lysine	0-6	regulatory protein opaque-2	Zea mays	46-54
2940088-2	1986	One of thirty murine monoclonal antibodies, raised by immunization with human plasmin-alpha 2-antiplasmin complex, was found to be directed against the high-affinity lysine-binding site in plasminogen.	Lysine	166-172	serpin family F member 2	Homo sapiens	86-105
9287001-6	1997	When a conserved lysine residue at position 42 that is involved in ATP binding was replaced with asparagine in both MalK subunits, maltose transport and ATPase activities were reduced to 1% of those of the wild type.	Lysine	17-23	ATPase	Escherichia coli	153-159
3877728-10	1985	The unique N-terminal amino acid sequences of both forms of CSF were the same: (Lys-Glu-Val-Ser-Glu-His-X-Ser-His-Met-Ile-Gly-Asn).	Lysine	80-83	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-63
9286108-0	1997	Regulation of lysine catabolism through lysine-ketoglutarate reductase and saccharopine dehydrogenase in Arabidopsis.	Lysine	14-20	Saccharopine dehydrogenase	Arabidopsis thaliana	75-101
9286108-1	1997	In plant and mammalian cells, excess lysine is catabolized by a pathway that is initiated by two enzymes, namely, lysine-ketoglutarate reductase and saccharopine dehydrogenase.	Lysine	37-43	Saccharopine dehydrogenase	Arabidopsis thaliana	149-175
2999782-0	1985	Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.	Lysine	0-6	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	61-64
9240466-3	1997	Glutamine235 and arginine272 in hMC5R were mutated to lysine (Q235K) and cysteine (R272C), respectively, residues which are conserved at these positions in other melanocortin receptor subtypes.	Lysine	54-60	melanocortin 5 receptor	Homo sapiens	32-37
3001744-1	1985	An aortic phosphatase which dephosphorylates several proteins including phosphorylase a and the 20-kDa myosin light chains is subject to modulation in vitro by polycationic effectors such as lysine-rich histone-H1 and polylysine.	Lysine	191-197	H1.0 linker histone	Homo sapiens	203-213
9263920-10	1997	In contrast, cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G17 with COOH-terminal glycine), was increased 3-fold after treatment with omeprazole for either 1 or 5 days.	Lysine	78-81	gastrin	Rattus norvegicus	66-73
9263920-10	1997	In contrast, cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G17 with COOH-terminal glycine), was increased 3-fold after treatment with omeprazole for either 1 or 5 days.	Lysine	78-81	gastrin	Rattus norvegicus	135-142
4049324-1	1985	Histidine-rich glycoprotein (HRG) has been reported to be a fibrinolysis regulating protein due to its capacity to bind to the high affinity lysine binding sites of plasminogen.	Lysine	141-147	histidine rich glycoprotein	Homo sapiens	0-27
9258448-2	1997	Conjugation of III to the epsilon-amino group of alpha-N-Boc-L-lysine, via the N-hydroxysuccinimde ester, IV, gave the Boc-protected fluorescein-conjugated lysine monomer V. Removal of the Boc group, followed by reaction with Fmoc chloride, gave the Fmoc-protected monomer, VI (Figure 1).	Lysine	63-69	BOC cell adhesion associated, oncogene regulated	Homo sapiens	57-60
9258448-2	1997	Conjugation of III to the epsilon-amino group of alpha-N-Boc-L-lysine, via the N-hydroxysuccinimde ester, IV, gave the Boc-protected fluorescein-conjugated lysine monomer V. Removal of the Boc group, followed by reaction with Fmoc chloride, gave the Fmoc-protected monomer, VI (Figure 1).	Lysine	63-69	BOC cell adhesion associated, oncogene regulated	Homo sapiens	119-122
9258448-2	1997	Conjugation of III to the epsilon-amino group of alpha-N-Boc-L-lysine, via the N-hydroxysuccinimde ester, IV, gave the Boc-protected fluorescein-conjugated lysine monomer V. Removal of the Boc group, followed by reaction with Fmoc chloride, gave the Fmoc-protected monomer, VI (Figure 1).	Lysine	63-69	BOC cell adhesion associated, oncogene regulated	Homo sapiens	119-122
9258448-3	1997	These Boc- and Fmoc-protected fluorescein-conjugated lysines were readily incorporated into peptides and PNA oligomers during solid phase synthesis to give fluorescent products.	Lysine	53-60	BOC cell adhesion associated, oncogene regulated	Homo sapiens	6-9
4049324-1	1985	Histidine-rich glycoprotein (HRG) has been reported to be a fibrinolysis regulating protein due to its capacity to bind to the high affinity lysine binding sites of plasminogen.	Lysine	141-147	histidine rich glycoprotein	Homo sapiens	29-32
4040396-1	1985	Tissue plasminogen activator produced by a human melanoma cell line (Bowes), was purified from large volumes of supernatant fluid using immunosorbent chromatography on monoclonal antibodies, followed by chromatography on lysine-Sepharose 4B and gel filtration on Sephadex G-150.	Lysine	221-228	chromosome 20 open reading frame 181	Homo sapiens	0-28
9149130-2	1997	In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate.	Lysine	80-86	eukaryotic translation initiation factor 5A2	Mus musculus	98-104
18634071-1	1997	The major component of the whey fraction of bovine milk, beta-lactoglobulin (betaLG), has been transformed by grafting polyethylene glycol chains either on the thiol group (free and after reduction of the S-S bridges) of the cysteine residues, or on the amino group of the lysine residues and/or of the N-terminal amino acid.	Lysine	273-279	beta-lactoglobulin	Bos taurus	57-75
2864042-6	1985	B-6 deficiency decreased the number of lysine residues in elastin that were converted into the cross-linking amino acid precursor allysine.	Lysine	39-45	elastin	Rattus norvegicus	58-65
9201397-8	1997	The hemagglutinin of Q1/95 and P11/ 94B parent stock and derivative AIVs had an identical proteolytic cleavage site of.... Pro-Gln-Arg-Lys-Arg-Lys-Thr-Arg-Gly, consistent with AIVs of high pathogenicity.	Lysine	135-138	S100 calcium binding protein A10	Gallus gallus	31-34
2859894-8	1985	Since the insoluble elastin accumulated in these cultures contain the unique lysine-derived cross-links in amounts comparable to aortic tissue, this culture system proves ideal for studying the influence of extracellular matrix elastin on cell growth and metabolism.	Lysine	77-83	elastin	Rattus norvegicus	20-27
9201397-8	1997	The hemagglutinin of Q1/95 and P11/ 94B parent stock and derivative AIVs had an identical proteolytic cleavage site of.... Pro-Gln-Arg-Lys-Arg-Lys-Thr-Arg-Gly, consistent with AIVs of high pathogenicity.	Lysine	143-146	S100 calcium binding protein A10	Gallus gallus	31-34
9093902-10	1997	Mutation of conserved lysine residues within the ATP binding domains of CK2 alpha and CK2 alpha" resulted in loss of kinase activity.	Lysine	22-28	casein kinase 2 alpha 2	Homo sapiens	72-81
9093902-10	1997	Mutation of conserved lysine residues within the ATP binding domains of CK2 alpha and CK2 alpha" resulted in loss of kinase activity.	Lysine	22-28	casein kinase 2 alpha 2	Homo sapiens	86-95
4004796-5	1985	Ca2+-induced phosphorylation of lysine-rich histone was enhanced over 3-fold in the presence of phosphatidylserine, and cyclic AMP-activated protein kinase activity was revealed with mixed histone as substrate.	Lysine	32-38	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	141-155
9047323-7	1997	The results from these experiments indicated that the native proteolytic site in MAG was located extracellularly and occurred between residues 512 (Ala) and 513 (Lys), with a large hydrophobic residue at the P2 position (Trp-511).	Lysine	162-165	myelin associated glycoprotein	Homo sapiens	81-84
9006906-6	1997	In ABC1, replacement of the conserved lysine 1892 in the Walker A motif of the second nucleotide binding fold increased the basal ionic flux, did not alter the pharmacological inhibitory profile, but abolished the response to orthovanadate and cAMP agonists.	Lysine	38-44	ATP binding cassette subfamily A member 1 S homeolog	Xenopus laevis	3-7
3156054-1	1985	Experiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmin-catalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen.	Lysine	171-177	carboxypeptidase B1	Homo sapiens	120-138
3938982-3	1985	Mature EGF was released by lysine specific proteolysis of a fusion protein consisting of part of the E. coli TrpE protein, a lysine linker and EGF polypeptide.	Lysine	27-33	EGF	Ovis aries	7-10
9016354-6	1997	The substitution of Arg2 or Arg4 in FRCRCFa with lysine or ornithine decreases the inhibitory potency by 5-12-fold, suggesting that both arginines are beneficial for inhibition.	Lysine	49-55	arginase 2	Homo sapiens	20-24
6150137-6	1984	Elastin is composed largely of glycine, proline, and other hydrophobic residues and contains multiple lysine-derived cross-links, such as the desmosines, which link the individual polypeptide chains into a rubber-like network.	Lysine	102-108	elastin	Homo sapiens	0-7
8973169-11	1996	On the basis of a computer-assisted molecular modeling analysis, it was determined that addition of a hydroxyl to the naphthyl 4-position, giving [1, 1-difluoro-1-[2-(4-hydroxynaphthalenyl)] methyl]phosphonic acid (8), could potentially replace a water molecule situated in the PTP1B-6 complex, thereby allowing new hydrogen-bonding interactions with Lys 120 and Tyr 46.	Lysine	351-354	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	278-283
6238036-3	1984	HMG 17 is phosphorylated predominantly in a single seryl residue, Ser 24 in the sequence Gln-Arg-Arg-Ser 24-Ala-Arg-Leu-Ser 28-Ala-Lys, with the second seryl moiety, Ser 28, modified to a markedly lesser degree.	Lysine	131-134	high mobility group nucleosomal binding domain 2	Homo sapiens	0-6
8910468-12	1996	Four SSeCKS domains containing Lys/Arg-rich motifs similar to the PKC phosphorylation site in MARCKS were phosphorylated in vitro by PKC.	Lysine	31-34	protein kinase C, alpha	Rattus norvegicus	66-69
8910468-12	1996	Four SSeCKS domains containing Lys/Arg-rich motifs similar to the PKC phosphorylation site in MARCKS were phosphorylated in vitro by PKC.	Lysine	31-34	protein kinase C, alpha	Rattus norvegicus	133-136
6093106-6	1984	The 22-residue amino-terminal sequence of brain CCK-58 was: Ala-Val-Gln-Lys-Val-Asp-Gly-Glu-Pro-Arg-Ala-His-Leu-Gly -Ala-Leu-leu-Ala-Arg-Tyr-Ile-Gln-, the same as the sequence found for canine intestinal CCK-58 from this pool of dogs.	Lysine	72-75	cholecystokinin	Canis lupus familiaris	48-51
8887660-2	1996	Multiple copies of ATX2 were found to reverse the aerobic auxotrophies of sod1(delta) mutants for lysine and methionine and also to enhance the resistance of these yeast strains to paraquat and atmospheric levels of oxygen.	Lysine	98-104	Mn(2+) transporter ATX2	Saccharomyces cerevisiae S288C	19-23
6147351-1	1984	Lysyl oxidase initiates the covalent cross-linking of elastin and collagen by oxidizing lysine residues in these proteins to alpha-aminoadipic-delta-semialdehyde.	Lysine	88-94	lysyl oxidase	Homo sapiens	0-13
8798678-1	1996	A dysfunctional C1INH with deletion of lysine 251.	Lysine	39-45	serpin family G member 1	Homo sapiens	16-21
8812829-0	1996	Overexpression, purification, and refolding of link module from human TSG-6 in Escherichia coli: effect of temperature, media, and mutagenesis on lysine misincorporation at arginine AGA codons.	Lysine	146-152	TNF alpha induced protein 6	Homo sapiens	70-75
6147351-1	1984	Lysyl oxidase initiates the covalent cross-linking of elastin and collagen by oxidizing lysine residues in these proteins to alpha-aminoadipic-delta-semialdehyde.	Lysine	88-94	elastin	Homo sapiens	54-61
6147351-2	1984	Sequences surrounding susceptible lysines in elastin are considerably different from those in collagen and yet the same enzyme can oxidize both substrates.	Lysine	34-41	elastin	Homo sapiens	45-52
6147351-7	1984	In addition, lysyl oxidase oxidized lysine in various proteins with basic isoelectric points and was much less or not active against various acidic proteins.	Lysine	36-42	lysyl oxidase	Homo sapiens	13-26
6541374-0	1984	A sensitive assay for tissue plasminogen activator activity in plasma, using adsorption on lysine-sepharose.	Lysine	91-97	chromosome 20 open reading frame 181	Homo sapiens	22-50
8605175-0	1996	The designed protein M(II)-Gly-Lys-His-Fos(138-211) specifically cleaves the AP-1 binding site containing DNA.	Lysine	31-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-42
8605175-1	1996	A new specific DNA cleavage protein, Gly-Lys-His-Fos(138-211), was designed, expressed, and characterized.	Lysine	41-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-52
8605192-1	1996	Thrombin has trypsin-like specificity for Arg-Xaa and Lys-Xaa peptide bonds; however, it is much more specific than trypsin, cleaving far fewer peptide bonds in macromolecular substrates.	Lysine	54-57	coagulation factor II, thrombin	Bos taurus	0-8
6208186-6	1984	PRF was purified from the "lysine-Sepharose eluate" by DEAE-cellulose column chromatography and gel filtration on a Sephadex G-100 column.	Lysine	27-33	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	0-3
8669984-7	1996	Interestingly, the aromatic side chains of the CCK-B antagonist Boc-Trp-Phg-Asp-(1-Nal)-N(Me)2 in its preferential conformation, overlap their corresponding moieties in the two non peptide CCK-B antagonists L-362,260 and LY-288,513.	Lysine	221-223	BOC cell adhesion associated, oncogene regulated	Homo sapiens	64-67
8729973-5	1996	Two of 17 carcinomas showed Ki-ras mutations, both in codon 12 (gly --&gt; lys and gly --&gt; arg).	Lysine	75-78	KRAS proto-oncogene, GTPase	Homo sapiens	28-34
6088969-4	1984	In this case copper ions increase the binding of PLP with the protein stabilizing Schiff bases produced by epsilon-NH2 group of lysine and PLP.	Lysine	128-134	proteolipid protein 1	Homo sapiens	49-52
8639500-3	1996	Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity.	Lysine	133-136	arginyl aminopeptidase	Homo sapiens	161-164
8639500-4	1996	In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34.	Lysine	148-151	arginyl aminopeptidase	Homo sapiens	127-130
6426509-6	1984	Evidence in support of this conclusion is provided by parallel studies on Alcaligenes faecalis azurin, which lacks these lysine residues.	Lysine	121-127	azurin	Alcaligenes faecalis	95-101
8901136-5	1996	In the XiamenUF allele it is a substitution of lysine (AAA) to asparagine (AAT) in exon 1 (residue 3).	Lysine	47-53	stress-sensitive B	Drosophila melanogaster	75-78
6317754-6	1983	However, a periodate-lysine fixative containing both paraformaldehyde and glutaraldehyde preserved esterase and showed good to excellent staining of Lyt-1, Thy-1.2, RA32C2, and F4/80.	Lysine	21-27	CD5 antigen	Mus musculus	149-154
8627176-7	1996	In addition, whereas p58 has a nonpolar transmembrane portion, p50 contains the charged amino acid Lys.	Lysine	99-102	activating signal cointegrator 1 complex subunit 1	Homo sapiens	63-66
6317754-6	1983	However, a periodate-lysine fixative containing both paraformaldehyde and glutaraldehyde preserved esterase and showed good to excellent staining of Lyt-1, Thy-1.2, RA32C2, and F4/80.	Lysine	21-27	adhesion G protein-coupled receptor E1	Mus musculus	177-182
6194822-2	1983	Residues 67 to 75 in myelin basic protein from several species comprise the sequence Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys that acts as an encephalitogenic determinant in the rabbit.	Lysine	117-120	myelin basic protein	Oryctolagus cuniculus	21-41
8549825-4	1996	Dihydroxyacetone transfer reactions catalyzed by transaldolase depend on Schiff base formation by a lysine residue.	Lysine	100-106	transaldolase 1	Homo sapiens	49-62
6194549-7	1983	It is suggested that faster rate of release of O2 from Hb B may be due to its having lysine at position HCl in the beta-chain whereas the other haemoglobins have arginine.	Lysine	85-91	hemoglobin subunit beta	Ovis aries	55-59
8549825-5	1996	Replacement of lysine-142 by glutamine using site-directed mutagenesis resulted in a complete loss of enzyme activity, suggesting that lysine-142 is essential for the catalytic activity of TAL-H.	Lysine	15-21	transaldolase 1	Homo sapiens	189-194
6816782-4	1982	Pigs fed the 13% protein diet containing added Lys (.17%) or Lys + C had average daily gains (ADG) similar to those fed the 16% protein diet (positive control group) and greater (P less than .05) than those of pigs fed the 13% protein diet (negative controls).	Lysine	47-50	ADG	Sus scrofa	94-97
8550590-0	1996	Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha.	Lysine	18-25	Ribosomal protein S27A	Drosophila melanogaster	55-64
6816782-4	1982	Pigs fed the 13% protein diet containing added Lys (.17%) or Lys + C had average daily gains (ADG) similar to those fed the 16% protein diet (positive control group) and greater (P less than .05) than those of pigs fed the 13% protein diet (negative controls).	Lysine	61-64	ADG	Sus scrofa	94-97
6816782-6	1982	Main effect comparisons among the 13% protein groups indicated that C increased (P less than .05) ADFI and ADG and that Lys increased (P less than .01) ADG and G:F ratio.	Lysine	120-123	ADG	Sus scrofa	152-155
6816782-13	1982	The combination of Lys + C further increased (P less than .05) the ADG over that of the high protein sequence group.	Lysine	19-22	ADG	Sus scrofa	67-70
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Lysine	105-111	purinergic receptor P2Y2	Homo sapiens	34-38
6816782-14	1982	Overall main effect comparisons among the low protein dietary sequence groups indicated that either added Lys or C increased (P less than .01) ADFI and ADG, with added Lys also increasing G:F ratio.	Lysine	106-109	ADG	Sus scrofa	152-155
6275900-7	1982	A peptide containing the amino acid sequence of histone H2b from Gly-26 to Lys-34 (Gly-Lys-Lys-Arg-Lys-Arg-Ser-Arg-Lys-Ala) was synthesized.	Lysine	75-78	cuticle collagen 13	Bos taurus	48-59
7592852-6	1995	The TGase 3 reaction favored certain lysines and glutamines by forming mostly intrachain cross-links, whereas TGase 1 formed mostly large oligomeric complexes by interchain cross-links involving different lysines and glutamines.	Lysine	37-44	transglutaminase 3	Homo sapiens	4-11
7592852-6	1995	The TGase 3 reaction favored certain lysines and glutamines by forming mostly intrachain cross-links, whereas TGase 1 formed mostly large oligomeric complexes by interchain cross-links involving different lysines and glutamines.	Lysine	205-212	transglutaminase 3	Homo sapiens	4-11
7236714-10	1981	Furthermore two of the fragments, namely K4 and K1+2+3 contain lysine-binding site(s).	Lysine	63-69	keratin 4	Homo sapiens	41-54
7488288-8	1995	Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar Arg/Lys residues, represent cross-reactive epitopes between the two proteins.	Lysine	239-242	HTLV-1 related endogenous sequence	Homo sapiens	22-28
6797167-0	1981	Decarboxylation of ornithine and lysine by ornithine decarboxylase from kidneys of testosterone treated mice.	Lysine	33-39	ornithine decarboxylase, structural 1	Mus musculus	43-66
7548083-0	1995	N-terminus and lysine side chain pKa values of melittin in aqueous solutions and micellar dispersions measured by 15N NMR.	Lysine	15-21	melittin	Apis mellifera	47-55
7548083-4	1995	Several, contradictory, indirect measurements of the pKa values of the three lysine groups in MLT have been reported.	Lysine	77-83	melittin	Apis mellifera	94-97
7548083-5	1995	In the present study, high-resolution 15N NMR at 50.6 MHz was used to directly measure the pKa values of the amino groups of the Gly-1, Lys-7, Lys-21, and Lys-23 residues of MLT.	Lysine	136-139	melittin	Apis mellifera	174-177
7548083-5	1995	In the present study, high-resolution 15N NMR at 50.6 MHz was used to directly measure the pKa values of the amino groups of the Gly-1, Lys-7, Lys-21, and Lys-23 residues of MLT.	Lysine	143-146	melittin	Apis mellifera	174-177
7548083-5	1995	In the present study, high-resolution 15N NMR at 50.6 MHz was used to directly measure the pKa values of the amino groups of the Gly-1, Lys-7, Lys-21, and Lys-23 residues of MLT.	Lysine	143-146	melittin	Apis mellifera	174-177
7548083-6	1995	Specifically, the pH dependence of MLT 15N chemical shifts was measured separately for the isotopically enriched backbone nitrogen of Gly-1 and the side chain nitrogen atoms of Lys-7, Lys-21, and Lys-23 at a MLT concentration of 1.2 mM and a temperature of 23 degrees C. Measurements were made for MLT in potassium phosphate buffer, in neat water, and in 1-myristoyl-2-hydroxyl-sn-glycero-3-phosphocholine (MMPC) lipid micelles.	Lysine	177-180	melittin	Apis mellifera	35-38
6263321-0	1980	The use of specific lysine modifications to locate the reaction site of cytochrome c with sulfite oxidase.	Lysine	20-26	sulfite oxidase	Homo sapiens	90-105
7665572-1	1995	Lysyl oxidase (EC 1.4.3.13), an extracellular copper amino oxidase, initiates the cross-linking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues.	Lysine	195-201	lysyl oxidase	Homo sapiens	0-13
6777755-4	1980	The nucleotide sequence predicts as in the case for gamma 1 and gamma 2b heavy chains an additional lysine residue before the termination codon.	Lysine	100-106	immunoglobulin heavy constant gamma 2B	Mus musculus	52-72
7567989-2	1995	The opaque2 mutation in maize doubles the lysine content in the endosperm, but the mechanism by which this occurs is unknown.	Lysine	42-48	regulatory protein opaque-2	Zea mays	4-11
7651402-4	1995	RAD55 and RAD57 contain putative nucleotide binding motifs, and the importance of these motifs was determined by constructing site-directed mutations of the conserved lysine residue within the Walker A-box.	Lysine	167-173	putative DNA-dependent ATPase RAD55	Saccharomyces cerevisiae S288C	0-5
7651402-4	1995	RAD55 and RAD57 contain putative nucleotide binding motifs, and the importance of these motifs was determined by constructing site-directed mutations of the conserved lysine residue within the Walker A-box.	Lysine	167-173	putative DNA-dependent ATPase RAD57	Saccharomyces cerevisiae S288C	10-15
7651402-5	1995	Changing the lysine residue to arginine or alanine resulted in a mutant phenotype in DNA repair and sporulation for Rad55 but not for Rad57.	Lysine	13-19	putative DNA-dependent ATPase RAD55	Saccharomyces cerevisiae S288C	116-121
7397217-6	1980	However, there are sequence similarities between HMG 18 and histone H5, and between HMG 19B and HMG 17, supporting the view that the HMG proteins and the lysine-rich histones are functionally related.	Lysine	154-160	high mobility group nucleosomal binding domain 2	Homo sapiens	96-102
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	61-68	proteolipid protein 1	Homo sapiens	45-48
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Lysine	126-129	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Lysine	134-137	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	61-68	proteolipid protein 1	Homo sapiens	248-251
7629078-5	1995	Although this domain contains the characteristic paired lysine residues found in other cross-linking domains of elastin, protein sequence analysis indicated that the first but not the second lysine had been oxidized by lysyl oxidase.	Lysine	56-62	elastin	Homo sapiens	112-119
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	175-178	proteolipid protein 1	Homo sapiens	45-48
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	175-178	proteolipid protein 1	Homo sapiens	248-251
7629090-2	1995	The data revealed that both FXa and FVa could accelerate tPA activity by as much as 60-fold for Lys-Pg and &gt; 150-fold for Glu-Pg.	Lysine	96-99	coagulation factor X	Homo sapiens	28-31
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	186-189	proteolipid protein 1	Homo sapiens	45-48
6247646-6	1980	It is calculated that the N-atoms of the two PLP-substituted lysines must be at a distance less than or equal to 12 A. Analysing our and literature data, one may suppose that Lys-13 and Lys-87 are the most probable candidates for modification with PLP.	Lysine	186-189	proteolipid protein 1	Homo sapiens	248-251
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Lysine	128-131	cuticle collagen 13	Bos taurus	265-276
7612595-3	1995	Previous investigations have suggested an important role for cationic residues in determination of toxin activity, and our single-site mutagenesis studies have indicated that isoform discrimination can be partially explained by the unique cationic residues Arg-12 and Lys-49 of anthopleurin B (ApB).	Lysine	268-271	arginyl aminopeptidase	Homo sapiens	294-297
8630877-12	1995	RESULTS: Only two missense point mutations and one nucleotide sequence polymorphism were detected: a TAC--&gt;TGC transition in codon 234 in exon 7, resulting in a Tyr--&gt;Lys substitution, a CGT--&gt;TGT transition in codon 273 in exon 8, resulting in an Arg--&gt;Cys substitution and a polymorphism (CGA--&gt;CGG) in codon 213 in exon 6.	Lysine	173-176	UDP glycosyltransferase 8	Homo sapiens	193-196
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Lysine	146-149	cuticle collagen 13	Bos taurus	73-84
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Lysine	146-149	cuticle collagen 13	Bos taurus	265-276
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Lysine	146-149	cuticle collagen 13	Bos taurus	73-84
7552094-7	1995	The modification of the VDR may involve Schiff base formation between lysine residues of the VDR DNA-binding domain and reactive aldehydes accumulated in uremia.	Lysine	70-76	vitamin D receptor	Homo sapiens	24-27
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Lysine	146-149	cuticle collagen 13	Bos taurus	265-276
7552094-7	1995	The modification of the VDR may involve Schiff base formation between lysine residues of the VDR DNA-binding domain and reactive aldehydes accumulated in uremia.	Lysine	70-76	vitamin D receptor	Homo sapiens	93-96
38849-0	1979	Affinity labeling of histidine and lysine residue in the adenosine deaminase substrate binding site.	Lysine	35-41	adenosine deaminase	Homo sapiens	57-76
8537329-1	1995	Maturation of human Protein C (HPC) precursor to a zymogen in the liver requires endoproteolytic cleavages after a basic dipeptide, Lys-2-Arg-1 in the propeptide and Lys156-Arg157 connecting the light and heavy chain.	Lysine	132-135	proline rich protein HaeIII subfamily 1	Homo sapiens	20-29
448473-2	1979	Lysine deficient rats ran more than those pair-fed or ad libitum fed the same diet with lysine added.	Lysine	0-6	RAN, member RAS oncogene family	Rattus norvegicus	22-25
7620566-3	1995	Internal Arg/Lys residues that become C-terminal upon proteolysis or zymogen activation, such as in the two-chain form of tissue plasminogen activator, may also be removed from the mature protein.	Lysine	13-16	chromosome 20 open reading frame 181	Homo sapiens	122-150
7782318-0	1995	Identification of lysines within alpha 1-antichymotrypsin important for DNA binding.	Lysine	18-25	serpin family A member 3	Homo sapiens	33-57
486492-8	1979	These experiments indicate that all of the detectable lysine decarboxylase activity in rat and mouse tissues was due to the action of ornithine decarboxylase and that significant cadaverine production in vivo would occur only when ornithine decarboxylase activity is high and lysine concentrations substantially exceed those of ornithine.	Lysine	54-60	ornithine decarboxylase, structural 1	Mus musculus	134-157
7549063-6	1995	The lysine binding sites situated in the kringle structures of plasminogen play a crucial role in the regulation of fibrinolysis by modulating its binding to fibrin and to cell surfaces, and by controlling the inhibition rate of plasmin by alpha 2-antiplasmin.	Lysine	4-10	serpin family F member 2	Homo sapiens	240-259
728413-3	1978	When the lysine-rich histones H1 and H5 were selectively removed from avian red blood cell nuclei, the rate of digestion with DNase I increased several fold.	Lysine	9-15	deoxyribonuclease 1	Homo sapiens	126-133
697732-1	1978	Reductive methylation of lysine residues activates liver alcohol dehydrogenase in the oxidation of primary alcohols, but decreases the activity of the enzyme towards secondary alcohols.	Lysine	25-31	aldo-keto reductase family 1 member A1	Homo sapiens	57-78
7727441-14	1995	pCPB is more specific for substrates with C-terminal arginine than those with C-terminal lysine for all the natural and synthetic peptides tested.	Lysine	89-95	carboxypeptidase B1	Homo sapiens	0-4
667683-8	1978	On the other hand, CPB is similar to trypsin (ibid) in that the best substrate would have a side chain length between those of lysine and arginine.	Lysine	127-133	carboxypeptidase B1	Homo sapiens	19-22
7721762-9	1995	Comparison of the propeptides of the active constructs suggests that a particular lysine residue is important for efficient biosynthesis of proteinase A.	Lysine	82-88	proteinase A	Saccharomyces cerevisiae S288C	140-152
7633329-8	1995	It is probable that specific amino groups of lysine residues on the GABAA receptor react in vivo with PLP to form Schiff bases, and that the in vivo modification of the receptor produces a degeneration of GABAergic neurotransmission leading to the onset of a convulsive fit.	Lysine	45-51	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	68-73
889877-3	1977	Evidence is presented that the glucagon sequence -Thr-Ser-Asp-Tyr-Ser-Lys-Tyr- is found in the gut GLI-1 as well.	Lysine	70-73	GLI family zinc finger 1	Homo sapiens	99-104
7880816-7	1995	ADR1 mutants with either His or Lys in the central +3 residue (146) of zinc finger two, which have Arg149 in the +6 alpha-helical position, bind with UAS1 mutant sequences having G5 very strongly, T5 strongly, A5 intermediately, and C5 weakly.	Lysine	32-35	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	0-4
265581-3	1977	The amino acid sequence analysis of tryptic peptide 17" of protein A24: (see text) showed it contains tryptic peptide 17 of histone 2A, Lys-Thr-Glu-Ser-His-His-Lys.	Lysine	136-139	immunoglobulin kappa variable 2-23 (pseudogene)	Homo sapiens	67-70
836035-0	1977	Lysine transfer RNA from liver: a sulfur-containing species that codes for AAG.	Lysine	0-6	N-methylpurine DNA glycosylase	Homo sapiens	75-78
7873529-6	1995	Modification of lysine residues of HPRG or competitive binding by lysine and anti-fibrinolytic agents containing primary amino groups also inhibits association.	Lysine	16-22	histidine rich glycoprotein	Homo sapiens	35-39
7873529-6	1995	Modification of lysine residues of HPRG or competitive binding by lysine and anti-fibrinolytic agents containing primary amino groups also inhibits association.	Lysine	66-72	histidine rich glycoprotein	Homo sapiens	35-39
7873529-8	1995	These results indicate that HPRG has independent binding sites for heparin and PLG and confirm that one or more lysine residues of HPRG are involved in its recognition by PLG.	Lysine	112-118	histidine rich glycoprotein	Homo sapiens	28-32
7873529-8	1995	These results indicate that HPRG has independent binding sites for heparin and PLG and confirm that one or more lysine residues of HPRG are involved in its recognition by PLG.	Lysine	112-118	histidine rich glycoprotein	Homo sapiens	131-135
7872772-3	1995	In contrast, chicken TPI, which contains a lysine at position 71, is terminally modified by the oxidation of Cys126.	Lysine	43-49	triosephosphate isomerase 1	Gallus gallus	21-24
868645-1	1977	The synthesis of elastin by smooth muscle cells is demostrated by amino acid analyses and the presence of lysine-derived crosslinks.	Lysine	106-112	elastin	Homo sapiens	17-24
7850982-11	1995	In fact, the amyloid fibrils were composed of transthyretin, and the two affected individuals from whom DNA was available were both heterozygotes for a single base change in exon 3 of the transthyretin gene, encoding substitution of Lys for the wild-type Thr residue at position 59 in the mature protein.	Lysine	233-236	transthyretin	Homo sapiens	188-201
796809-9	1976	The incorporation of lysine in the elastin fraction increased by a factor 10 in the grafted vein as compared to the non-grafted veins.	Lysine	21-27	elastin	Canis lupus familiaris	35-42
7735837-2	1995	The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk.	Lysine	18-24	Rap guanine nucleotide exchange factor 1	Homo sapiens	77-80
7735837-5	1995	A lysine in the C3G peptide is tightly coordinated by three acidic residues in the SH3 domain.	Lysine	2-8	Rap guanine nucleotide exchange factor 1	Homo sapiens	16-19
7735837-7	1995	CONCLUSIONS: The c-Crk SH3 domain engages in an unusual lysine-specific interaction that is rarely seen in protein structures, and which appears to be a key determinant of its unique ability to bind the C3G peptides with high affinity.	Lysine	56-62	Rap guanine nucleotide exchange factor 1	Homo sapiens	203-206
1247503-2	1976	Analysis of tryptic peptides containing methionine or lysine indicated that parathyroid hormone, proparathyroid hormone, and pre-proparathyroid hormone had several common peptides.	Lysine	54-60	parathyroid hormone	Bos taurus	76-95
7827055-1	1995	A novel photoinduced electron-transfer reaction is reported in complexes between resting ferric state cytochrome c peroxidase (CcP) and several horse cytochrome c derivatives labeled at single lysine amino groups with [bis(bipyridine)](dicarboxybipyridine)ruthenium(II) (Ru-CC).	Lysine	193-199	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	102-125
7827055-1	1995	A novel photoinduced electron-transfer reaction is reported in complexes between resting ferric state cytochrome c peroxidase (CcP) and several horse cytochrome c derivatives labeled at single lysine amino groups with [bis(bipyridine)](dicarboxybipyridine)ruthenium(II) (Ru-CC).	Lysine	193-199	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	127-130
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Lysine	129-132	CD8a molecule	Homo sapiens	73-76
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Lysine	129-132	CD8a molecule	Homo sapiens	177-180
7830771-4	1995	This is primarily explained by coordinate binding of ligand molecules by CD8 and TCR, because substitution of Asp 227 of Kd with Lys severely impaired the TCR-ligand binding on CD8+, but not CD8- cells.	Lysine	129-132	CD8a molecule	Homo sapiens	177-180
1247503-3	1976	Two lysine-containing peptides present in proparathyroid hormone but not in parathyroid hormone were also present in pre-proparathyroid hormone.	Lysine	4-10	parathyroid hormone	Bos taurus	45-64
1247503-4	1976	In addition, pre-proparathyroid hormone contained several additional lysine- and methionine-containing peptides not present in parathyroid hormone or proparathyroid hormone.	Lysine	69-75	parathyroid hormone	Bos taurus	20-39
24419545-3	1974	On the other hand, percent lysine in the whole kernel, lysine yield per hectare and percent lysine in protein are increased by 53, 45 and 55 percent, respectively, in the o 2 inbred lines and hybrids compared with their normal analogues.	Lysine	27-33	regulatory protein opaque-2	Zea mays	171-174
7837233-1	1995	Analogs of the CCK-A receptor selective agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623) were prepared in which the lysine residue was replaced with L-4-aminophenylalanine and D-or L-3-aminophenylalanine.	Lysine	116-122	cholecystokinin A receptor	Homo sapiens	15-29
7605205-2	1995	Ts 412 has a single base substitution (G100--&gt;A) leading to an amino acid replacement (Arg 25--&gt;Lys) in the NS1 protein.	Lysine	102-105	influenza virus NS1A binding protein	Homo sapiens	114-117
24419545-3	1974	On the other hand, percent lysine in the whole kernel, lysine yield per hectare and percent lysine in protein are increased by 53, 45 and 55 percent, respectively, in the o 2 inbred lines and hybrids compared with their normal analogues.	Lysine	55-61	regulatory protein opaque-2	Zea mays	171-174
24419545-5	1974	As well as lysine, the content of other amino acids, such as aspartic acid, arginine, glycine, threonine, valine and histidine are also, in general, increased by the presence of the o 2 gene in recessive homozygous condition.The results obtained have shown that a number of correlation coefficients between the protein quality traits and yield components related to kernel characteristics are negative and significant, especially in the presence of the o 2 gene in recessive homozygous condition.	Lysine	11-17	regulatory protein opaque-2	Zea mays	182-185
24419545-7	1974	They are a stronger positive correlation of percent protein with percent lysine, and lysine yield per hectare with 1000 grain weight, in o 2 maize than in normal maize.The results presented here also show that there is more heterotic dilution in the o 2 hybrids than in the normal analogues for traits like percent protein, percent lysine (whole kernel basis) and percent lysine in protein.	Lysine	85-91	regulatory protein opaque-2	Zea mays	137-140
24419545-7	1974	They are a stronger positive correlation of percent protein with percent lysine, and lysine yield per hectare with 1000 grain weight, in o 2 maize than in normal maize.The results presented here also show that there is more heterotic dilution in the o 2 hybrids than in the normal analogues for traits like percent protein, percent lysine (whole kernel basis) and percent lysine in protein.	Lysine	85-91	regulatory protein opaque-2	Zea mays	137-140
24419545-7	1974	They are a stronger positive correlation of percent protein with percent lysine, and lysine yield per hectare with 1000 grain weight, in o 2 maize than in normal maize.The results presented here also show that there is more heterotic dilution in the o 2 hybrids than in the normal analogues for traits like percent protein, percent lysine (whole kernel basis) and percent lysine in protein.	Lysine	85-91	regulatory protein opaque-2	Zea mays	137-140
4659651-0	1972	Structural studies of alanine- and lysine-rich regions of porcine aortic tropoelastin.	Lysine	35-41	elastin	Homo sapiens	73-85
8575267-4	1995	With the reference values chosen at fx = 1, the most hydrophobic residues of elastin, Tyr (Y) and Phe (F), have low values of Tt, -55 and -30 degrees C, respectively, and the most hydrophilic residues, Glu (E-), Asp (D-) and Lys (K+), have high values of 250, 170 and 120 degrees C, respectively.	Lysine	225-228	elastin	Homo sapiens	77-84
4340477-0	1972	The lysines in liver alcohol dehydrogenase.	Lysine	4-11	aldo-keto reductase family 1 member A1	Homo sapiens	21-42
7982963-6	1994	Substitution of a lysine residue at position 2 in this peptide by tyrosine abolished the specificity difference by increasing the affinities of the DnaK and hsc70 proteins 5- and 20-fold, respectively, and that of BiP by greater than 2 orders of magnitude.	Lysine	18-24	heat shock protein family A (Hsp70) member 8	Homo sapiens	157-162
4233783-0	1967	Amino acid sequences of N- and C-terminal and lysine-containing peptides of collagen and elastin.	Lysine	46-52	elastin	Homo sapiens	89-96
8001738-1	1994	Histone H1 zero was initially described as a member of the lysine-rich histone class, typically present in nondividing mammalian cells.	Lysine	59-65	H1.0 linker histone	Homo sapiens	0-10
7947827-13	1994	Whereas the rate of thrombin inhibition was similar to that of wild-type antithrombin, the rate of factor Xa inhibition was enhanced between 2- and 3-fold, suggesting a role for lysine 125 in the allosteric coupling between the heparin binding site and the reactive center region.	Lysine	178-184	coagulation factor X	Homo sapiens	99-108
13752072-0	1960	[On the effect of various nutrition deficiency states on the incorporation of C-14 labelled lysine into the body proteins of young rats with some results in newborn rabbits].	Lysine	92-98	anti-Mullerian hormone receptor type 2	Rattus norvegicus	78-82
7961659-8	1994	The results 1) confirm the predictions of the model that Asn-204, Glu-256, and Glu-290 are important residues involved in catalysis and hydrogen bonding glucose hydroxyl groups, 2) provide evidence for a role of Lys-56 in hexose binding, and 3) are consistent with the cooperative behavior of glucokinase being mediated by interactions of other regions of the protein with the highly conserved active site glucose binding residues.	Lysine	212-215	glucokinase	Homo sapiens	293-304
7957235-4	1994	In contrast, a BDNF mutant with a single amino-acid replacement (Arg-1--&gt;Lys) in the basic processing site common to all neurotrophin precursors elutes as a single peak.	Lysine	76-79	brain derived neurotrophic factor	Homo sapiens	15-19
13573365-0	1958	Labeling of histones and other nuclear proteins with L-lysine-U-C14 in tissues of tumor-bearing rats.	Lysine	53-61	anti-Mullerian hormone receptor type 2	Rattus norvegicus	64-67
7957235-4	1994	In contrast, a BDNF mutant with a single amino-acid replacement (Arg-1--&gt;Lys) in the basic processing site common to all neurotrophin precursors elutes as a single peak.	Lysine	76-79	brain derived neurotrophic factor	Homo sapiens	124-136
33617987-1	2021	KAT8 is a lysine acetyltransferase (KAT) that plays a role in a variety of cellular functions ranging from DNA damage repair to apoptosis.	Lysine	10-16	katanin p80 (WD40-containing) subunit B 1	Mus musculus	0-3
7703837-5	1994	For example, interactions between aromatic residues contribute to the stability of the NGF dimer, and specific surface lysine residues participate in receptor contacts.	Lysine	119-125	nerve growth factor	Mus musculus	87-90
7929459-2	1994	AR contains an EGF-like domain (residues 44-84) and a Lys/Arg-rich NH2-terminal extension (residues 1-43).	Lysine	54-57	amphiregulin	Homo sapiens	0-2
33838133-8	2021	2) More histone deacetylase 7 (HDAC7) instead of lysine acetyltransferase 8 (KAT8) enrichment at the promoter of OAT2 led to low levels of histone 4 lysine 16 acetylation (H4K16ac).	Lysine	49-55	solute carrier family 22 member 7	Homo sapiens	113-117
7841367-1	1994	We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways.	Lysine	135-138	mesothelin	Homo sapiens	65-68
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Lysine	64-67	reticulon 4	Rattus norvegicus	93-99
7841367-1	1994	We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways.	Lysine	139-142	mesothelin	Homo sapiens	65-68
8049245-2	1994	Exposure of HGL to trypsin led to the production of three identified fragments (H1, H2 and H3) resulting from cleavage sites at Lys-4 and Arg-229.	Lysine	128-131	relaxin 2	Homo sapiens	84-93
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Lysine	64-67	reticulon 4	Rattus norvegicus	182-188
34047554-6	2021	Targeting a lysine residue at the interface of the composite 14-3-3 complex, which can be targeted explicitly via aldimine-forming fragments, we studied the de novo design of PPI stabilizers under consideration of potential selectivity.	Lysine	12-18	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	61-67
34031383-4	2021	LSD1 colocalized with ACE2 at the cell surface to maintain demethylated SARS-CoV-2 spike receptor-binding domain lysine 31 to promote virus-ACE2 interactions.	Lysine	113-119	lysine demethylase 1A	Homo sapiens	0-4
7527422-3	1994	The proteolytic cleavage of GDA-J/F3 protein by trypsin, which also caused sperm decapitation, indicated the presence of peptide bonds involving the carboxyl groups of the basic amino acids, arginine and/or lysine.	Lysine	207-213	guanine deaminase	Homo sapiens	28-31
33743195-2	2021	KDM4A, as a histone H3 lysine 9 trimethylation (H3K9me3) demethylase, has been found to play a critical role in squamous cell carcinoma (SCC) growth and metastasis.	Lysine	23-29	lysine demethylase 4A	Homo sapiens	0-5
7948099-3	1994	We found that derivatizing lysine residues of B3(Fv)-PE38 causes a marked loss of specific target cell cytotoxicity and/or immunoreactivity.	Lysine	27-33	immunoglobulin kappa variable 4-1	Homo sapiens	46-57
7948099-4	1994	Here we show that two lysine residues in the antibody-combining region of B3(Fv)-PE38 can be replaced with arginines, with only a small loss of cytotoxicity and no change in specificity.	Lysine	22-28	immunoglobulin kappa variable 4-1	Homo sapiens	74-85
34014148-0	2021	Optimized structure of monoubiquitinated FANCD2 (human) at Lys 561: a theoretical approach.	Lysine	59-62	FA complementation group D2	Homo sapiens	41-47
7928754-8	1994	The lysine requirements (ileal digestible lysine/DE, grams/megaJoule), determined with a linear-plateau model, were .57 for ADG and gain/feed, and .62 for protein deposition.	Lysine	4-10	ADG	Sus scrofa	124-127
33999620-1	2021	Plant homeodomain finger protein 1 (PHF1) is an accessory component of the gene silencing complex polycomb repressive complex 2 and recognizes the active chromatin mark, trimethylated lysine 36 of histone H3 (H3K36me3).	Lysine	184-190	PHD finger protein 1	Homo sapiens	0-34
7525451-3	1994	Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469.	Lysine	85-88	intercellular adhesion molecule 1	Homo sapiens	49-55
33999620-1	2021	Plant homeodomain finger protein 1 (PHF1) is an accessory component of the gene silencing complex polycomb repressive complex 2 and recognizes the active chromatin mark, trimethylated lysine 36 of histone H3 (H3K36me3).	Lysine	184-190	PHD finger protein 1	Homo sapiens	36-40
33986438-3	2021	LSD1 that is highly expressed in PSCs can directly interact with and demethylate OCT4 at lysine 222 (K222) in the flexible linker region.	Lysine	89-95	lysine demethylase 1A	Homo sapiens	0-4
33978814-3	2021	Tau acetylation occurs at lysine 280 resulting from increased expression of the lysine acetyltransferase p300.	Lysine	26-32	E1A binding protein p300	Mus musculus	105-109
8201590-1	1994	A series of novel CCK tetrapeptide analogues of the general formula Boc-Trp-Lys(Tac)-N(R)-(CH2)nCON(R")Phe-NH2 (Tac = o-tolylaminocarbonyl), where R,R" = H or Me and n = 1-5, have been synthesized and tested.	Lysine	76-79	cholecystokinin	Rattus norvegicus	18-21
8052410-2	1994	The neurotensin/neuromedin N precursor molecule possesses four lysine-arginine dibasic residues which represent potential sites of cleavage by proteolytic maturation enzymes.	Lysine	63-70	neurotensin	Rattus norvegicus	4-15
33978814-3	2021	Tau acetylation occurs at lysine 280 resulting from increased expression of the lysine acetyltransferase p300.	Lysine	80-86	E1A binding protein p300	Mus musculus	105-109
33978814-15	2021	Mechanistically, we found that increased Rbbp7 reduced p300 levels, tau acetylation at lysine 280 and tau phosphorylation at AT8 and AT100 sites.	Lysine	87-93	retinoblastoma binding protein 7, chromatin remodeling factor	Mus musculus	41-46
33975961-3	2021	Binding domain mapping showed that the CC1 domain of VP3 and the residue lysine-155 of tumor necrosis factor receptor-associated factor 3 (TRAF3) are essential for the interaction.	Lysine	73-79	TNF receptor associated factor 3	Homo sapiens	139-144
33975961-5	2021	A ubiquitination assay showed that lysine-155 of TRAF3 was the critical residue for K33-linked polyubiquitination, which contributes to the formation of a TRAF3-TBK1 complex.	Lysine	35-41	TNF receptor associated factor 3	Homo sapiens	49-54
8159793-5	1994	The third transcript encoded the SbHRGP-3 protein containing a variant of 9- or 10-amino acid canonical repeats: Ser-Pro4-Tyr-Lys-Tyr-Pro, Ser-Pro5-Tyr-Lys-Tyr-Pro, and Ser-Pro4-Val-Tyr-Lys-Tyr-Lys, respectively.	Lysine	126-129	SBHRGP3	Glycine max	33-41
33975961-5	2021	A ubiquitination assay showed that lysine-155 of TRAF3 was the critical residue for K33-linked polyubiquitination, which contributes to the formation of a TRAF3-TBK1 complex.	Lysine	35-41	TNF receptor associated factor 3	Homo sapiens	155-160
8159793-5	1994	The third transcript encoded the SbHRGP-3 protein containing a variant of 9- or 10-amino acid canonical repeats: Ser-Pro4-Tyr-Lys-Tyr-Pro, Ser-Pro5-Tyr-Lys-Tyr-Pro, and Ser-Pro4-Val-Tyr-Lys-Tyr-Lys, respectively.	Lysine	152-155	SBHRGP3	Glycine max	33-41
8159793-5	1994	The third transcript encoded the SbHRGP-3 protein containing a variant of 9- or 10-amino acid canonical repeats: Ser-Pro4-Tyr-Lys-Tyr-Pro, Ser-Pro5-Tyr-Lys-Tyr-Pro, and Ser-Pro4-Val-Tyr-Lys-Tyr-Lys, respectively.	Lysine	152-155	SBHRGP3	Glycine max	33-41
33975961-6	2021	Subsequently, we revealed that VP3 blocked TRAF3-TBK1 complex formation through reducing K33-linked polyubiquitination of lysine-155 on TRAF3.	Lysine	122-128	TNF receptor associated factor 3	Homo sapiens	43-48
33975961-6	2021	Subsequently, we revealed that VP3 blocked TRAF3-TBK1 complex formation through reducing K33-linked polyubiquitination of lysine-155 on TRAF3.	Lysine	122-128	TNF receptor associated factor 3	Homo sapiens	136-141
33975961-9	2021	In this study, we first identified that K33-linked polyubiquitination of lysine-155 of TRAF3 enhances the interaction with TBK1, which positively regulates the host IFN immune response.	Lysine	73-79	TNF receptor associated factor 3	Homo sapiens	87-92
8300582-4	1994	Mutagenesis and protease digestion studies of the recombinant HB-EGF, coupled with heparin-binding analyses of synthetic peptides, indicated that the sequences within HB-EGF mediating its interaction with heparin are located primarily in a stretch of 21 amino acids characterized by a high content of lysine and arginine residues.	Lysine	301-307	proheparin-binding EGF-like growth factor	Cricetulus griseus	167-173
33975961-10	2021	Meanwhile, we discovered that the interaction of the CC1 domain of the Avibirnavirus VP3 protein and the residue lysine-155 of TRAF3 reduced the K33-linked polyubiquitination of TRAF3 and blocked the formation of the TRAF3-TBK1 complex, which contributed to the downregulation of host IFN signaling, supporting viral replication.	Lysine	113-119	TNF receptor associated factor 3	Homo sapiens	127-132
33975961-10	2021	Meanwhile, we discovered that the interaction of the CC1 domain of the Avibirnavirus VP3 protein and the residue lysine-155 of TRAF3 reduced the K33-linked polyubiquitination of TRAF3 and blocked the formation of the TRAF3-TBK1 complex, which contributed to the downregulation of host IFN signaling, supporting viral replication.	Lysine	113-119	TNF receptor associated factor 3	Homo sapiens	178-183
7904603-0	1994	Lys-17 is the amine-donor substrate site for transglutaminase in beta A3-crystallin.	Lysine	0-3	crystallin beta A1	Bos taurus	65-83
33975961-10	2021	Meanwhile, we discovered that the interaction of the CC1 domain of the Avibirnavirus VP3 protein and the residue lysine-155 of TRAF3 reduced the K33-linked polyubiquitination of TRAF3 and blocked the formation of the TRAF3-TBK1 complex, which contributed to the downregulation of host IFN signaling, supporting viral replication.	Lysine	113-119	TNF receptor associated factor 3	Homo sapiens	178-183
33969633-3	2022	These findings converge on altered post-translational modifications on two key lysine (K) residues of the H3 tail, K27 and K36, which regulate several cellular processes, including those linked to cell differentiation during development.	Lysine	79-85	keratin 36	Homo sapiens	123-126
7904603-1	1994	The bovine lens protein beta A3-crystallin has recently been shown to be an amine-donor (Lys) substrate for tissue-type transglutaminase, using a newly developed amine-acceptor hexapeptide as a probe (Groenen, P.J.T.A., Seccia, M., Smulders, R.H.P.H., Gravela, E., Cheeseman, K.H., Bloemendal, H., and de Jong, W.W. (1993) Biochem.	Lysine	89-92	crystallin beta A1	Bos taurus	24-42
7904603-8	1994	Transglutaminase-mediated cross-linking of beta A3-crystallin also gives rise to a beta A3 dimer, presumably due to the fact that Lys-17 can be cross-linked to the previously established Gln-7 or Gln-8 amine-acceptor site.	Lysine	130-133	crystallin beta A1	Bos taurus	43-61
33979575-0	2021	Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.	Lysine	29-35	histone H3	Saccharomyces cerevisiae S288C	15-25
7517709-3	1994	Competition ELISA experiments defined a proline and lysine rich octapeptide PKPEPKPK as the major epitope recognized by more than 70% of the HMG-17 positive JRA sera.	Lysine	52-58	high mobility group nucleosomal binding domain 2	Homo sapiens	141-147
33979575-0	2021	Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.	Lysine	29-35	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	51-55
33979575-3	2021	Here, we show that histone H3 lysine 37 mono-methylation (H3K37me1) is catalyzed by Set1p and Set2p and that it regulates replication origin licensing.	Lysine	30-36	histone H3	Saccharomyces cerevisiae S288C	19-29
33979575-3	2021	Here, we show that histone H3 lysine 37 mono-methylation (H3K37me1) is catalyzed by Set1p and Set2p and that it regulates replication origin licensing.	Lysine	30-36	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	94-99
33922251-3	2021	GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5), a well-known enzymatic protein responsible for the lysine acetylation of histone H3 and H4, is a universal and crucial histone acetyltransferase involved in gene transcription and plant development.	Lysine	93-99	general control non-repressible 5	Arabidopsis thaliana	0-33
7765950-5	1994	The system employed in this study consisted of mouse insulinoma beta TC3 cells entrapped in calcium alginate/poly-L-lysine (PPL)/alginate beads.	Lysine	109-122	periplakin	Mus musculus	124-127
33922251-3	2021	GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5), a well-known enzymatic protein responsible for the lysine acetylation of histone H3 and H4, is a universal and crucial histone acetyltransferase involved in gene transcription and plant development.	Lysine	93-99	general control non-repressible 5	Arabidopsis thaliana	35-39
33854041-6	2021	Intriguingly, p62 protein stability could be reduced by its acetylation at lysine 295, which was regulated by deacetylase Sirt1 and acetyltransferase GCN5.	Lysine	75-81	sequestosome 1	Homo sapiens	14-17
8245689-4	1993	In contrast, modification of amino group(s) in N-terminal and lysine residues inhibits activated Hageman factor.	Lysine	62-68	coagulation factor XII	Homo sapiens	97-111
33854041-6	2021	Intriguingly, p62 protein stability could be reduced by its acetylation at lysine 295, which was regulated by deacetylase Sirt1 and acetyltransferase GCN5.	Lysine	75-81	sirtuin 1	Homo sapiens	122-127
7907025-5	1993	Spiperone, spiperone plus propranolol, LY 53857, ketanserin and propranolol antagonised the pressor effects of DOI suggesting the stimulation of both 5-HT2 and 5-HT1C receptors.	Lysine	39-41	5-hydroxytryptamine receptor 2C	Rattus norvegicus	160-166
33854041-6	2021	Intriguingly, p62 protein stability could be reduced by its acetylation at lysine 295, which was regulated by deacetylase Sirt1 and acetyltransferase GCN5.	Lysine	75-81	lysine acetyltransferase 2A	Homo sapiens	150-154
33854041-10	2021	Taken together, Sirt1 deacetylates p62 at lysine 295 to disturb Keap1-mediated p62 poly-ubiquitination, thus up-regulating p62 expression to promote hepato-carcinogenesis.	Lysine	42-48	nucleoporin 62	Mus musculus	35-38
33636247-4	2021	Our PEG-P[Lys/Lys(fructose)]-BPA could be internalized into tumor cells through LAT1 amino acid transporter-mediated endocytosis and retain in the targeted cells, thereby accomplishing more efficient accumulation and retention in a subcutaneous tumor than clinically used fructose-BPA complexes.	Lysine	10-13	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	80-84
8227060-8	1993	U.S.A. 78, 187-191) in which the GMP is linked to the large subunit through a lysine residue (Toyama, R., Mizumoto, K., Nakahara, Y., Tatsuno, T., and Kaziro, Y.	Lysine	78-84	5'-nucleotidase, cytosolic II	Homo sapiens	33-36
8227060-14	1993	In order to identify the map position of the guanyltransferase active site lysine residue, high specific activity [32P]E-GMP was prepared.	Lysine	75-81	5'-nucleotidase, cytosolic II	Homo sapiens	121-124
8227060-18	1993	Staphylococcus aureus V8 protease digestion of cyanogen bromide-cleaved E-GMP yields a radioactive product of about 5 kDa in molecular mass corresponding to the peptide generated by cleavage at glutamic acid residues 253 and 297, demonstrating that lysine 260 is the site of linkage of GMP.	Lysine	249-255	5'-nucleotidase, cytosolic II	Homo sapiens	74-77
33636247-4	2021	Our PEG-P[Lys/Lys(fructose)]-BPA could be internalized into tumor cells through LAT1 amino acid transporter-mediated endocytosis and retain in the targeted cells, thereby accomplishing more efficient accumulation and retention in a subcutaneous tumor than clinically used fructose-BPA complexes.	Lysine	14-17	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	80-84
33838681-10	2021	Cloning and mutagenesis were used to identify a lysine acceptor site that mediates NLRP7 ubiquitination.	Lysine	48-54	NLR family pyrin domain containing 7	Homo sapiens	83-88
7504284-3	1993	The MPZ point mutation in 18 of 18 related CMT1B pedigree 1 patients converts a positively charged lysine in codon 96 to a negatively charged glutamate.	Lysine	99-105	myelin protein zero	Homo sapiens	4-7
7504284-3	1993	The MPZ point mutation in 18 of 18 related CMT1B pedigree 1 patients converts a positively charged lysine in codon 96 to a negatively charged glutamate.	Lysine	99-105	myelin protein zero	Homo sapiens	43-48
8218226-6	1993	Like PACE, PACE4 was able to process pro-vWF to its mature form, and efficient cleavage required both the P4 arginine and the P2 lysine.	Lysine	129-135	proprotein convertase subtilisin/kexin type 6	Homo sapiens	11-16
33838681-16	2021	K379 was an important lysine acceptor site that mediates NLRP7 ubiquitination in CRC cells.	Lysine	22-28	NLR family pyrin domain containing 7	Homo sapiens	57-62
33916919-7	2021	Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation.	Lysine	102-108	reactive intermediate imine deaminase A homolog	Homo sapiens	34-39
33279621-0	2021	Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.	Lysine	0-6	ribonucleic acid export 1	Homo sapiens	35-40
8240286-2	1993	To perturb the tetrameric structure of yeast phosphoglycerate mutase we have prepared a mutant enzyme in which Lys-168 in the subunit-contact region has been replaced by proline.	Lysine	111-114	phosphoglycerate mutase	Saccharomyces cerevisiae S288C	45-68
33279621-4	2021	Here, we showed that the shedding of the mouse NKG2D ligand Rae-1 can be prevented by two critical acetyltransferases, GCN5 and PCAF, which acetylate the lysine residues of Rae-1 to avoid shedding both in vitro and in vivo.	Lysine	154-160	ribonucleic acid export 1	Mus musculus	60-65
33347048-6	2021	Deletion of BAP1 in B16-F10 cells leads to preferential downregulation of genes accompanied with increased H2A ubiquitination at lysine 119.	Lysine	129-135	Brca1 associated protein 1	Mus musculus	12-16
8229308-0	1993	Porcine somatotropin affects the dietary lysine requirement and net lysine utilization for growing pigs.	Lysine	41-47	somatotropin	Sus scrofa	8-20
33432631-3	2021	To better understand how SYD functions, we profiled the genome-wide occupancy of SYD and its impact on the global transcriptome and deposition of trimethylation of histone H3 on lysine 27 (H3K27me3).	Lysine	178-184	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	25-28
8229308-0	1993	Porcine somatotropin affects the dietary lysine requirement and net lysine utilization for growing pigs.	Lysine	68-74	somatotropin	Sus scrofa	8-20
8229308-1	1993	This study was conducted to determine the effects of exogenous porcine somatotropin (pST) on the dietary lysine requirement and efficiency of absorbed lysine utilization for pigs during the 20- to 60-kg phase of growth.	Lysine	105-111	somatotropin	Sus scrofa	71-83
8229308-1	1993	This study was conducted to determine the effects of exogenous porcine somatotropin (pST) on the dietary lysine requirement and efficiency of absorbed lysine utilization for pigs during the 20- to 60-kg phase of growth.	Lysine	151-157	somatotropin	Sus scrofa	71-83
32737855-4	2021	CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase (HAT) domain, leading to acetylation of Slug at lysines 166 and 211.	Lysine	154-161	snail family transcriptional repressor 2	Homo sapiens	53-57
8251629-0	1993	Concerted regulation of lysine and threonine synthesis in tobacco plants expressing bacterial feedback-insensitive aspartate kinase and dihydrodipicolinate synthase.	Lysine	24-30	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	136-164
8251629-3	1993	Addressing this issue, we have expressed in transgenic tobacco plants high levels of bacterial AK and DHPS, which are much less sensitive to feedback inhibition by lysine and threonine than their plant counterparts.	Lysine	164-170	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	102-106
8251629-4	1993	Such expression of the bacterial DHPS by itself resulted in a substantial overproduction of lysine, whereas plants expressing only the bacterial AK overproduced threonine.	Lysine	92-98	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	33-37
8251629-5	1993	When both bacterial enzymes were expressed in the same plant, the level of free lysine exceeded by far the level obtained by the bacterial DHPS alone.	Lysine	80-86	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	139-143
8251629-7	1993	Our results suggested that in tobacco plants the synthesis of both lysine and threonine is under a concerted regulation exerted by AK, DHPS, and possibly also by HSD.	Lysine	67-73	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	135-139
8251629-8	1993	We propose that the balance between lysine and threonine synthesis is determined by competition between DHPS and HSD on limiting amounts of their common substrate 3-aspartic semialdehyde, whose level, in turn, is determined primarily by the activity of AK.	Lysine	36-42	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	104-108
32737855-4	2021	CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase (HAT) domain, leading to acetylation of Slug at lysines 166 and 211.	Lysine	154-161	snail family transcriptional repressor 2	Homo sapiens	146-150
32737855-6	2021	Notably, Slug acetylation, mediated by CBP at lysines 166 and 211, doubles its half-life and increases its stability.	Lysine	46-53	snail family transcriptional repressor 2	Homo sapiens	9-13
8373159-13	1993	This movement of the lysine residue results in the formation of a cavity on the surface of the cytochrome b5 molecule, which exposes a heme methyl and vinyl group to aqueous solvent thereby destabilizing the binding between the protein and its hydrophobic prosthetic heme group.	Lysine	21-27	cytochrome b5 type A	Rattus norvegicus	95-108
33615660-4	2021	The attachment of cyclic deca-arginine (cR10) modified with a single lysine linked to DABCYL to synthetic ubiquitin (Ub) and small ubiquitin-like modifier-2 (SUMO-2) scaffolds resulted in a threefold higher uptake efficacy in live cells compared to the unmodified cR10.	Lysine	69-75	SUMO2 pseudogene 21	Homo sapiens	125-156
8344203-2	1993	Furin cleaves the concensus processing site -Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1-.	Lysine	55-58	arginase 2	Homo sapiens	59-70
33615660-4	2021	The attachment of cyclic deca-arginine (cR10) modified with a single lysine linked to DABCYL to synthetic ubiquitin (Ub) and small ubiquitin-like modifier-2 (SUMO-2) scaffolds resulted in a threefold higher uptake efficacy in live cells compared to the unmodified cR10.	Lysine	69-75	SUMO2 pseudogene 21	Homo sapiens	158-164
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Lysine	147-150	vitronectin	Homo sapiens	187-196
8314764-6	1993	AdoMet synthetases possess the consensus ATP-binding motif Gly-X-Gly-X-X-Gly and a putative ATP-binding Lys residue at conserved locations.	Lysine	104-107	methionine adenosyltransferase I, alpha	Mus musculus	0-6
33712741-4	2021	In addition, we found that OGD-induced nuclear translocation of PTEN is dependent on PTEN mono-ubiquitination at the lysine 13 residue (K13) that is mediated by neural precursor cell expressed developmentally downregulated protein 4-1 (NEDD4-1).	Lysine	117-123	phosphatase and tensin homolog	Rattus norvegicus	64-68
8369438-3	1993	The epsilon-Lys-216 chemical shifts in bR555 (48 ppm) and bR568 (53 ppm) are consistent with a C = N isomerization from syn in bR555 to anti in bR568.	Lysine	12-15	synemin	Homo sapiens	120-123
8512310-1	1993	Inactivations of chicken liver pyruvate carboxylase with N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide (DACM) and o-phthalaldehyde (o-PA) have identified cysteine and lysine residues that are essential for catalytic activity.	Lysine	172-178	pyruvate carboxylase	Gallus gallus	31-51
33712741-4	2021	In addition, we found that OGD-induced nuclear translocation of PTEN is dependent on PTEN mono-ubiquitination at the lysine 13 residue (K13) that is mediated by neural precursor cell expressed developmentally downregulated protein 4-1 (NEDD4-1).	Lysine	117-123	phosphatase and tensin homolog	Rattus norvegicus	85-89
33859801-1	2021	Human sirtuins (SIRT1-7) regulate not only deacetylation but also deacylation of fatty acid-derived acyl moieties (defatty-acylation) at the epsilon-amino group of lysine residues.	Lysine	164-170	sirtuin 1	Homo sapiens	16-23
8389451-3	1993	3T3-L1 fibroblasts expressing an activated mutant (Lys-61) N-Ras protein exhibited a 3-fold increase in 2-deoxyglucose uptake rates compared with non-transfected cells.	Lysine	51-54	NRAS proto-oncogene, GTPase	Homo sapiens	59-64
7690980-1	1993	The insertion of two lysine residues (cleavage sites of cathepsin B) at the boundary of a peptide recognized by B cells (BD) and a class-II- presentable sequence (TDh) enhanced the anti-BD antibody induction capacity of this type of peptide construct, as well as production of IL2.	Lysine	21-27	cathepsin B	Homo sapiens	56-67
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Lysine	36-39	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
33713703-2	2021	It has been suggested that S. cerevisiae employs an active mechanism to maintain gene expression homeostasis through Rtt109-Asf1-dependent acetylation of histone H3 on lysine 56 (H3K56).	Lysine	168-174	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	124-128
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	91-97	TRAF3 interacting protein 2	Homo sapiens	198-202
8471039-3	1993	NN precedes NT and is separated from it by a Lys-Arg sequence.	Lysine	45-48	neurotensin	Rattus norvegicus	0-2
8471039-11	1993	Because two of the antigenic sequences, i.e. NN and the NN-like sequence, start with a lysine residue that is essential for recognition by their respective antisera, a micromethod by which trypsin specifically cleaves at arginine residues was developed.	Lysine	87-93	neurotensin	Rattus norvegicus	45-47
33658352-6	2021	Phosphorylated IL-17RB recruits the ubiquitin ligase tripartite motif containing 56 to add lysine-63-linked ubiquitin chains to lysine-470 of IL-17RB, which further assembles NF-kappaB activator 1 (ACT1) and other factors to propagate downstream oncogenic signaling.	Lysine	128-134	TRAF3 interacting protein 2	Homo sapiens	198-202
33508542-10	2021	Moreover, clozapine increased the acetylation of histone H3 at lysine 27 residues (H3K27) in MIF promoter.	Lysine	63-69	H3 clustered histone 7	Mus musculus	49-59
8468349-5	1993	Differences in the subcellular distribution and rate of post-translational modification of CD8 maintained in the ER by sequences derived from a variety of ER resident proteins suggested that the efficiency of retrieval was dependent on the sequence context of the double lysine motif and that retrieval may be initiated from multiple positions along the exocytotic pathway.	Lysine	271-277	CD8a molecule	Homo sapiens	91-94
8428004-8	1993	Addition of a CpB inhibitor to the plasma enhanced fibrinogenolysis by thromb-UK and pro-UK by approximately 16%, consistent with the promotion of both forms by certain C-terminal lysines.	Lysine	180-187	carboxypeptidase B1	Homo sapiens	14-17
33492339-4	2021	KDM4A demethylates lysine 9 (H3K9me2/3) and lysine 36 (H3K36me3) methyl marks on histone H3.	Lysine	19-25	lysine demethylase 4A	Homo sapiens	0-5
1335425-2	1992	However the surface potential is slightly decreased (approximately 3 mV) when PLP(Lys 86)-cytochrome c and PLP(Lys 79)-cytochrome c were added.	Lysine	82-85	proteolipid protein 1	Homo sapiens	78-81
1335425-2	1992	However the surface potential is slightly decreased (approximately 3 mV) when PLP(Lys 86)-cytochrome c and PLP(Lys 79)-cytochrome c were added.	Lysine	111-114	proteolipid protein 1	Homo sapiens	107-110
33492339-4	2021	KDM4A demethylates lysine 9 (H3K9me2/3) and lysine 36 (H3K36me3) methyl marks on histone H3.	Lysine	44-50	lysine demethylase 4A	Homo sapiens	0-5
33636024-5	2021	Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4alpha (HNF4alpha) protein by binding to and deacetylating HNF4alpha on lysine 458.	Lysine	136-142	hepatic nuclear factor 4, alpha	Mus musculus	38-70
1327161-2	1992	Various o- and p-quinones were assessed as oxidants of peptidyl lysine in elastin and collagen substrates in the presence and absence of divalent copper as paradigms of protein-lysine 6-oxidase (lysyl oxidase) which contains both quinone and copper cofactors.	Lysine	64-70	elastin	Homo sapiens	74-81
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	32-35	acyl-CoA oxidase 1	Homo sapiens	99-102
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	32-35	acyl-CoA oxidase 1	Homo sapiens	180-183
33636024-5	2021	Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4alpha (HNF4alpha) protein by binding to and deacetylating HNF4alpha on lysine 458.	Lysine	136-142	hepatic nuclear factor 4, alpha	Mus musculus	72-81
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	62-65	acyl-CoA oxidase 1	Homo sapiens	81-97
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	62-65	acyl-CoA oxidase 1	Homo sapiens	99-102
33636024-5	2021	Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4alpha (HNF4alpha) protein by binding to and deacetylating HNF4alpha on lysine 458.	Lysine	136-142	hepatic nuclear factor 4, alpha	Mus musculus	123-132
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	62-65	acyl-CoA oxidase 1	Homo sapiens	180-183
33624836-5	2021	To resolve this product quality issue, we developed an enzyme treatment method by introducing carboxypeptidase B (CpB) to clip the C-terminal lysine, leading to significantly increased main peak and an acceptable and more homogenous product quality for all the intensified processes.	Lysine	142-148	carboxypeptidase B1	Homo sapiens	94-112
1568468-11	1992	These in vitro and in vivo observations strongly suggest that MDP-Lys(L18) indirectly enhances the proliferation and differentiation of mouse CFU-Meg via colony-stimulating factor(s) other than IL-1, probably as a result of the stimulation of macrophages to produce IL-6.	Lysine	66-69	ribosomal protein L18	Mus musculus	70-73
33624836-5	2021	To resolve this product quality issue, we developed an enzyme treatment method by introducing carboxypeptidase B (CpB) to clip the C-terminal lysine, leading to significantly increased main peak and an acceptable and more homogenous product quality for all the intensified processes.	Lysine	142-148	carboxypeptidase B1	Homo sapiens	114-117
1565649-6	1992	Although conserved, the lysine present in thioredoxin was shown not to be essential for its redox activity.	Lysine	24-30	thioredoxin 1	Mus musculus	42-53
33596982-3	2021	Lysine-specific demethylase 5A (KDM5A, also known as JARID1A or RBP2) is a KDM5 Jumonji histone demethylase subfamily member that erases di- and tri-methyl groups from lysine 4 of histone H3.	Lysine	168-174	lysine demethylase 5A	Homo sapiens	0-30
1372554-10	1992	Here we show that poly(lysine), but neither NaCl nor heparin, specifically enhances the phosphorylation efficiency of lyn TPK for the peptide EDNEYTA (src peptide).	Lysine	23-29	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	151-154
33596982-3	2021	Lysine-specific demethylase 5A (KDM5A, also known as JARID1A or RBP2) is a KDM5 Jumonji histone demethylase subfamily member that erases di- and tri-methyl groups from lysine 4 of histone H3.	Lysine	168-174	lysine demethylase 5A	Homo sapiens	32-37
33586321-9	2021	Microscale thermophoresis studies supported our hypothesis, with AtDHDPS1 having a ~6-fold tighter lysine dissociation constant compared to AtDHDPS2, which agrees with the lower half minimal inhibitory concentration for lysine observed.	Lysine	220-226	dihydrodipicolinate synthase	Arabidopsis thaliana	140-148
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Lysine	173-176	kexin KEX2	Saccharomyces cerevisiae S288C	104-108
33562796-4	2021	A prototypical histone acetyltransferase (HAT) known as general control non-repressed protein 5 (GCN5), was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14.	Lysine	200-206	lysine acetyltransferase 2A	Homo sapiens	56-95
16668738-17	1992	In addition, the decreased reductase activity caused by the opaque-2 mutation may explain, at least in part, the elevated concentration of lysine found in the opaque-2 endosperm.	Lysine	139-145	regulatory protein opaque-2	Zea mays	60-68
16668738-17	1992	In addition, the decreased reductase activity caused by the opaque-2 mutation may explain, at least in part, the elevated concentration of lysine found in the opaque-2 endosperm.	Lysine	139-145	regulatory protein opaque-2	Zea mays	159-167
33562796-4	2021	A prototypical histone acetyltransferase (HAT) known as general control non-repressed protein 5 (GCN5), was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14.	Lysine	200-206	lysine acetyltransferase 2A	Homo sapiens	97-101
33482060-3	2021	KDM5-C70 treatment activated the glial fibrillary acidic protein (Gfap) gene by increasing the trimethylation of histone H3 lysine 4 in the promoter regions and subsequently induced astrocytogenesis in NSCs.	Lysine	124-130	glial fibrillary acidic protein	Rattus norvegicus	33-64
1364220-4	1992	Sequence analysis of the amplified product revealed a GAG &gt; AAG transversion at codon 26, which resulted in an amino acid substitution of lysine for glutamic acid.	Lysine	141-147	N-methylpurine DNA glycosylase	Homo sapiens	63-66
1730031-5	1992	The second-order rate constant for the inhibition of the low-Mr plasminogen-staphylokinase complex (plasminogen lacking the kringle structures comprising the lysine-binding sites) by alpha 2-antiplasmin was about 30-fold lower (9.3 +/- 0.7.10(4) M-1 s-1, mean +/- S.D.	Lysine	158-164	serpin family F member 2	Homo sapiens	183-202
1730031-8	1992	Our results confirm and establish that rapid inhibition of plasminogen-staphylokinase by alpha 2-antiplasmin requires the availability of the lysine-binding sites in the plasminogen moiety of the complex.	Lysine	142-148	serpin family F member 2	Homo sapiens	89-108
33482060-3	2021	KDM5-C70 treatment activated the glial fibrillary acidic protein (Gfap) gene by increasing the trimethylation of histone H3 lysine 4 in the promoter regions and subsequently induced astrocytogenesis in NSCs.	Lysine	124-130	glial fibrillary acidic protein	Rattus norvegicus	66-70
1730031-9	1992	Fibrin, but not fibrinogen, reduces the inhibition rate by alpha 2-antiplasmin by competition for interaction with the lysine-binding site.	Lysine	119-125	serpin family F member 2	Homo sapiens	59-78
32745625-2	2021	Its enzymatic activity involves a histone acetyltransferase module (HATm) that acetylates multiple lysine residues on the N-terminal tails of histones H2B and H3 and a deubiquitination module (DUBm) that triggers co-transcriptional deubiquitination of histone H2B.	Lysine	99-105	histone H2B	Saccharomyces cerevisiae S288C	252-263
1730582-3	1992	The pyridoxal 5"-phosphate binding lysine in mouse ODC was identified as lysine 69 of the mouse sequence by reduction of the purified holoenzyme form with NaB[3H]4 followed by digestion of the carboxymethylated protein with endoproteinase Lys-C, radioactive peptide mapping using reversed-phase high pressure liquid chromatography and gas-phase peptide sequencing.	Lysine	35-41	ornithine decarboxylase, structural 1	Mus musculus	51-54
1730582-3	1992	The pyridoxal 5"-phosphate binding lysine in mouse ODC was identified as lysine 69 of the mouse sequence by reduction of the purified holoenzyme form with NaB[3H]4 followed by digestion of the carboxymethylated protein with endoproteinase Lys-C, radioactive peptide mapping using reversed-phase high pressure liquid chromatography and gas-phase peptide sequencing.	Lysine	73-79	ornithine decarboxylase, structural 1	Mus musculus	51-54
1730582-6	1992	Using a similar procedure to analyze ODC labeled by reaction with [5-14C]DFMO, it was found that lysine 69 and cysteine 360 formed covalent adducts with the inhibitor.	Lysine	97-103	ornithine decarboxylase, structural 1	Mus musculus	37-40
32841743-2	2021	In the case of Gcn5, the target is the epsilon-amino group of lysine primarily on histones.	Lysine	62-68	lysine acetyltransferase 2A	Homo sapiens	15-19
1531511-5	1992	Cathepsin B/L-like activity was determined with Bz-Val-Lys-Lys-Arg-AFC, elastase-like activity with MeOSuc-Ala-Ala-Pro-Val-AFC, tryptase-like activity with Z-Ala-Ala-Lys-AFC, trypsin-like activity with Z-Gly-Gly-Arg-AFC and dipeptidyl peptidase (DPP) IV-like activity with Ala-Pro-AFC.	Lysine	55-58	cathepsin B	Homo sapiens	0-11
32890768-2	2021	Gcn5 (KAT2A) is a histone acetyltransferase that catalyzes the post-translational modification at multiple positions of histone H3 through the transfer of acetyl groups to the free amino group of lysine residues.	Lysine	196-202	lysine acetyltransferase 2A	Homo sapiens	0-4
32890768-2	2021	Gcn5 (KAT2A) is a histone acetyltransferase that catalyzes the post-translational modification at multiple positions of histone H3 through the transfer of acetyl groups to the free amino group of lysine residues.	Lysine	196-202	lysine acetyltransferase 2A	Homo sapiens	6-11
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Lysine	91-97	solute carrier family 7 member 1	Homo sapiens	0-6
1685472-1	1991	Lysyl oxidase (EC 1.4.3.13) initiates the crosslinking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues.	Lysine	154-160	lysyl oxidase	Homo sapiens	0-13
1716854-6	1991	This base substitution predicted the replacement of a positively charged lysine by a neutral asparagine (K59N), an amino acid change consistent with the more electronegative charge of the ALAD-2 subunit.	Lysine	73-79	aminolevulinate dehydratase	Homo sapiens	188-192
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Lysine	91-97	solute carrier family 7 member 1	Homo sapiens	7-11
33058867-12	2021	Of the acetyltransferases responsible for H3K9ac, cholangiocytes predominantly express Lysine Acetyltransferases 2A (KAT2A).	Lysine	87-93	K(lysine) acetyltransferase 2A	Mus musculus	117-122
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Lysine	178-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
33010070-2	2021	In this study, we show that histone H2B mono-ubiquitination (H2Bub) at lysine 123 was maintained at a low level in the yeast state, whereas it increased significantly during yeast-to-hyphae transition and decreased when hyphae converted to yeast.	Lysine	71-77	histone H2B	Saccharomyces cerevisiae S288C	28-39
33349663-5	2021	We show, molecularly, that the interaction of the 6B strain with epithelial cells leads to chromatin remodelling within the IL-11 promoter in a KDM6B-dependent manner, where KDM6B specifically demethylates histone H3 lysine 27 dimethyl.	Lysine	217-223	interleukin 11	Mus musculus	124-129
1681991-5	1991	The iontophoretic application of CCK reduced these attenuating effects of DA, LY 171555 and SKF 38393 + LY 171555.	Lysine	78-80	cholecystokinin	Rattus norvegicus	33-36
33349663-5	2021	We show, molecularly, that the interaction of the 6B strain with epithelial cells leads to chromatin remodelling within the IL-11 promoter in a KDM6B-dependent manner, where KDM6B specifically demethylates histone H3 lysine 27 dimethyl.	Lysine	217-223	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	144-149
33349663-5	2021	We show, molecularly, that the interaction of the 6B strain with epithelial cells leads to chromatin remodelling within the IL-11 promoter in a KDM6B-dependent manner, where KDM6B specifically demethylates histone H3 lysine 27 dimethyl.	Lysine	217-223	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	174-179
33981480-1	2021	Lysine demethylase 6B (KDM6B) is a histone H3 lysine 27 (H3K27) demethylase that serves as a key mediator of gene transcription.	Lysine	46-52	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	23-28
1883932-6	1991	Each lysine residue that was added to Lys2 decreased by one order of magnitude the concentration of peptide required to reverse the charge on the vesicle; equivalently it increased by one order of magnitude the binding affinity of the peptides for the PS vesicles.	Lysine	5-11	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	38-42
33414463-1	2021	Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell.	Lysine	0-6	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	36-41
1674697-8	1991	It is concluded that in this cell type (i) somatostatin-14 is exclusively generated by dibasic cleavage at the Arg-2-Lys-1 site of the intact precursor with concomitant production of prosomatostatin[1-76], and (ii) no direct interactions between the monobasic and dibasic processing domains occur.	Lysine	117-120	somatostatin	Homo sapiens	43-58
1674697-8	1991	It is concluded that in this cell type (i) somatostatin-14 is exclusively generated by dibasic cleavage at the Arg-2-Lys-1 site of the intact precursor with concomitant production of prosomatostatin[1-76], and (ii) no direct interactions between the monobasic and dibasic processing domains occur.	Lysine	117-120	arginase 2	Homo sapiens	111-116
33414441-5	2021	Mechanism dissection revealed that ADT decreases the EHF transcription via relieving the AR binding to different androgen-responsive elements, which then promotes the expression and enzymatic activity of enhancer of zeste homolog 2 (EZH2), consequently catalyzing tri-methylation lysine 27 of histone H3 for transcriptional repression of its downstream genes to promote the NED.	Lysine	280-286	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	204-231
32698753-0	2021	QSAR Modeling, Molecular Docking and Molecular Dynamics Simulations Studies of Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Anticancer Agents.	Lysine	79-85	lysine demethylase 1A	Homo sapiens	110-114
1901730-2	1991	It reacts with lysine residues connected with aminotransferase activity and the binding of 1 mol of reduced bis-PLP/enzyme monomer abrogates catalytic activity.	Lysine	15-21	proteolipid protein 1	Homo sapiens	112-115
1901730-6	1991	The amino acid sequence of the radioactive peptide, elucidated by Edman degradation, revealed that a specific lysine residue of monomeric 4-aminobutyrate aminotransferase has reacted with bis-PLP.	Lysine	110-116	proteolipid protein 1	Homo sapiens	192-195
33153976-1	2021	BACKGROUND: The chromodomain (CD) of HP1 proteins is an established H3K9me3 reader that also binds H1, EHMT2 and H3K23 lysine-methylated targets.	Lysine	119-125	euchromatic histone lysine methyltransferase 2	Homo sapiens	103-108
2001710-1	1991	The histidine at position 55 of the amino acid sequence of the Escherichia coli single-stranded DNA binding protein was replaced by tyrosine, glutamic acid, lysine, phenylalanine, and isoleucine.	Lysine	157-163	single-stranded DNA-binding protein	Escherichia coli	80-115
33162067-8	2021	In addition, activation of GCN2 as measured by increased phosphorylation of eIF2alpha Ser51 during the deprivation of Arg, Leu, and Lys combined and of Arg alone was sustained for up to 8 h of deprivation.	Lysine	132-135	eukaryotic translation initiation factor 2A	Bos taurus	76-85
1988940-3	1991	Inhibition of DNA ligase I activity by pyridoxal 5"-phosphate also indicated the presence of a reactive lysine residue in the catalytic domain of the enzyme.	Lysine	104-110	DNA ligase 1	Bos taurus	14-26
33340793-4	2021	The Jumonji domain protein 3 (JMJD3) is a specific histone demethylase of trimethylation at lysine 27 of histone-H3 (H3K27me3).	Lysine	92-98	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	4-28
1685643-3	1991	This mutation at codon 200 changes glutamic acid coded by GAG to lysine coded by AAG.	Lysine	65-71	N-methylpurine DNA glycosylase	Homo sapiens	81-84
1980002-8	1990	ORF2 is responsible for AEC resistance and lysine production due to a feedback-resistant aspartokinase.	Lysine	43-49	hypothetical protein	Corynebacterium glutamicum	0-4
33340793-4	2021	The Jumonji domain protein 3 (JMJD3) is a specific histone demethylase of trimethylation at lysine 27 of histone-H3 (H3K27me3).	Lysine	92-98	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	30-35
33340793-4	2021	The Jumonji domain protein 3 (JMJD3) is a specific histone demethylase of trimethylation at lysine 27 of histone-H3 (H3K27me3).	Lysine	92-98	H3 clustered histone 7	Mus musculus	105-115
33378746-1	2020	Histone modifications, specifically in the lysine residues of histone H3, have been implicated in lifespan regulation in several model organisms.	Lysine	43-49	H3 clustered histone 7	Mus musculus	62-72
2247846-6	1990	These mutations would result in amino acid substitutions of lysine, leucine, or arginine for the normal glutamine at position 61 in the N-ras protein.	Lysine	60-66	NRAS proto-oncogene, GTPase	Homo sapiens	136-141
33378746-7	2020	Furthermore, early GH intervention increased expression of histone H3 acetylation at multiple lysine residues in a tissue-specific manner.	Lysine	94-100	H3 clustered histone 7	Mus musculus	59-69
2261483-3	1990	Direct examination of the formation and breakdown of the ES complex shows its formation occurs within milliseconds at 25 degrees C. The best heptapeptide substrate, Dns-Pro-Lys-Arg-Ala-Pro-Trp-Val, is cleaved only between the Arg-Ala (P1-P1") bond with kinetic parameters kcat = 380 s-1 and Km = 3.7 x 10(-4) M. The presence of Lys or Arg in the P1 and P2 positions yields high-turnover substrates.	Lysine	173-176	crystallin gamma F, pseudogene	Homo sapiens	346-355
33391046-3	2020	Studies have reported that the reduction in lysine 16 of histone H4 acetylation coheres with autophagy induction.	Lysine	44-50	histone cluster 2, H4	Rattus norvegicus	57-67
2170024-4	1990	The combined substitution of two noncontinuous sequences of cathepsin D (lysine 203 and amino acids 265-292) into the analogous positions of glycopepsinogen resulted in phosphorylation of the oligosaccharides of the expressed chimeric molecule.	Lysine	73-79	cathepsin D	Xenopus laevis	60-71
33008594-7	2020	General control nonderepressible 2 and AMP-activated protein kinase were involved in lysine deprivation-mediated inhibition of mTORC1.	Lysine	85-91	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	0-34
33298158-8	2020	Chromatin immunoprecipitation and Western blot analyses found that GSK-J4 treatment elevated the levels of the Kdm6a and Kdm6b epigenetic target, the repressive mark of tri-methylated lysine 27 on histone 3, on osteogenic genes leading to repression of Runx2 and Alkaline Phosphatase expression.	Lysine	184-190	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	121-126
2121129-3	1990	These domains are covalently modified with lipoyl groups bound in amide linkage to the N6-amino groups of specific lysine residues, and the cofactors perform essential roles in the formation and transfer of acetyl groups by the dehydrogenase (E1p) and acetyltransferase (E2p) subunits.	Lysine	115-121	acetyltransferase	Escherichia coli	243-269
33299050-3	2020	Here, we identify new unnatural lysine analogues as substrates for human methyltransferases SETD7, SETD8, G9a and GLP.	Lysine	32-38	euchromatic histone lysine methyltransferase 2	Homo sapiens	106-109
1973689-8	1990	In the apoA-IV-3 allele we identified a single G to A substitution that converts the glutamic acid (GAG) at position 230 of the mature protein to a lysine (AAG), thus adding 2 positive charge units to the apoA-IV-1 isoprotein (pI 4.97) and forming the more basic apoA-IV-3 isoprotein (pI 5.08).	Lysine	148-154	N-methylpurine DNA glycosylase	Homo sapiens	156-159
33299050-5	2020	Our results demonstrate that these lysine analogues are mono-, di-, and trimethylated to a different extent by trimethyltransferases G9a and GLP.	Lysine	35-41	euchromatic histone lysine methyltransferase 2	Homo sapiens	133-136
2188100-3	1990	Substitution of a highly conserved lysine residue in the kinase domain abolished GCN2 regulatory function in vivo and its ability to autophosphorylate in vitro, indicating that GCN2 acts as a protein kinase in stimulating GCN4 expression.	Lysine	35-41	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	177-181
33232677-1	2020	KDM4B is a lysine-specific demethylase with a preferential activity on H3K9 tri/di-methylation (H3K9me3/2)-modified histones.	Lysine	11-17	lysine (K)-specific demethylase 4B	Mus musculus	0-5
33318631-0	2020	LSD1: more than demethylation of histone lysine residues.	Lysine	41-47	lysine demethylase 1A	Homo sapiens	0-4
2119043-4	1990	Administration of OKY-046, ONO-3708, AA-861 and LY-171883 for 12 weeks suppressed the elevation of serum GOT and GPT levels and histopathological changes in CCl4-induced chronic liver injury.	Lysine	48-50	chemokine (C-C motif) ligand 4	Mus musculus	157-161
2110898-3	1990	The C-terminal Lys-58 in the A chain is highly susceptible to removal by a carboxypeptidase-B-like activity causing the formation of des-Lys58-beta 2-microglobulin.	Lysine	15-18	carboxypeptidase B1	Homo sapiens	75-93
33318631-5	2020	In this review, we analyze the molecular mechanism by which LSD1 displays its dual effect on gene expression (related to the specific lysine target), placing final emphasis on the use of pharmacological inhibitors of its activity in future clinical studies to fight cancer.	Lysine	134-140	lysine demethylase 1A	Homo sapiens	60-64
32154934-5	2020	A crucial component of small ubiquitin-related modifiers (SUMOs) E3 ligase, RANBP2, is activated by SIRT1 and it is indispensable for FTO SUMOylation at Lysine (K)-216 site that promotes FTO degradation.	Lysine	153-159	sirtuin 1	Homo sapiens	100-105
2155113-1	1990	The residual motion of spin labels bound to cysteine beta 93 and to lysines of methemoglobin has been studied by electron paramagnetic resonance spectroscopy.	Lysine	68-75	hemoglobin subunit gamma 2	Homo sapiens	79-92
32916306-9	2020	Furthermore, changes in the plasma metabolites glycine, betaine, methionine and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression.	Lysine	80-86	solute carrier family 6 member 3	Homo sapiens	179-182
2295684-15	1990	These data suggest that transient increases in [Ca2+]i may be required for the migration of human neutrophils on poly-D-lysine-coated glass in the presence of serum by allowing them to release from previous sites of attachment.	Lysine	120-126	carbonic anhydrase 2	Homo sapiens	48-51
33256805-1	2020	BACKGROUND: The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethylation on lysine 9 of histone H3 (H3K9me3) in mouse embryonic stem cells (mESCs).	Lysine	250-256	H3 clustered histone 7	Mus musculus	262-272
33823549-5	2021	We further show that DDX19A binds to tri-methylated lysine 27 of histone 3 (H3K27me3) and it regulates gene expression through the removal of transcription promoting R-loops.	Lysine	52-58	DEAD-box helicase 19A	Homo sapiens	21-27
33823549-6	2021	Our results uncover a novel transcriptional regulatory cascade where the downregulation of genes is dependent on the LSD1 mediated demethylation of histone H3 lysine 4 (H3K4).	Lysine	159-165	lysine demethylase 1A	Homo sapiens	117-121
33223508-7	2020	Further mechanistic studies demonstrated that histone H3 lysine 36 trimethylation (H3K36me3) catalyzed by SETD2 interacted with the promoter of CXCL1 to regulate its transcription and downstream signaling pathways, contributing to tumorigenesis in vitro and in vivo.	Lysine	57-63	C-X-C motif chemokine ligand 1	Homo sapiens	144-149
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 associated RING domain 1	Homo sapiens	75-80
32649985-6	2020	Upon ROS exposure, UNG2 is deacetylated at lysine 78 by histone deacetylases, which prevents the UNG2-UHRF1 interaction.	Lysine	43-49	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	102-107
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 DNA repair associated	Homo sapiens	106-111
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 DNA repair associated	Homo sapiens	106-111
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 associated RING domain 1	Homo sapiens	75-80
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 DNA repair associated	Homo sapiens	106-111
33789098-4	2021	SIRT2 complexes with BRCA1-BARD1 and deacetylates conserved lysines in the BARD1 RING domain, interfacing BRCA1, which promotes BRCA1-BARD1 heterodimerization and consequently BRCA1-BARD1 stability, nuclear retention, and localization to DNA damage sites, thus contributing to efficient HR.	Lysine	60-67	BRCA1 associated RING domain 1	Homo sapiens	75-80
33113107-2	2021	The recent discovery in 2006 of the genetic defect antiquitin (ALDH7A1, OMIM #266100) has helped to understand the underlying mechanism, which is the accumulation of neurotoxic intermediates in the lysine catabolic pathway.	Lysine	198-204	aldehyde dehydrogenase 7 family member A1	Homo sapiens	63-70
33104714-0	2020	Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling.	Lysine	40-46	lysine demethylase 2A	Homo sapiens	24-29
33771929-4	2021	In a high WNT environment, a lysine within the highly conserved ZF-NC domain of ZIC5 is SUMOylated, which decreases formation of the TCF/ZIC co-repressor complex and shifts the balance towards transcription factor function.	Lysine	29-35	zinc finger protein of the cerebellum 5	Mus musculus	80-84
33771929-4	2021	In a high WNT environment, a lysine within the highly conserved ZF-NC domain of ZIC5 is SUMOylated, which decreases formation of the TCF/ZIC co-repressor complex and shifts the balance towards transcription factor function.	Lysine	29-35	zinc finger protein of the cerebellum 1	Mus musculus	80-83
33799631-0	2021	The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.	Lysine	89-95	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
33104714-2	2020	Here, we demonstrate that alternative isoforms of the KDM2A and KDM2B lysine demethylases have the ability to negatively regulate canonical Wnt signaling.	Lysine	70-76	lysine demethylase 2A	Homo sapiens	54-59
33104725-5	2020	UBE2L6-mediated ubiquitination of 3D requires a cystine at residue 86 in UBE2L6, and lysines at residues 169 and 321 in 3D.	Lysine	85-92	ubiquitin conjugating enzyme E2 L6	Homo sapiens	0-6
33097091-2	2020	The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a reader of lysine 9 di- and tri-methylation on histone H3 (H3K9me2/me3) and, more recently, lysine 126 di- and tri-methylation on DNA ligase 1 (LIG1K126me2/me3).	Lysine	76-82	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	33-38
33815817-3	2021	We use chromatin immunoprecipitation-qPCR to quantify tri-methylation at histone 3 lysine 4 (H3K4me3) and 27 (H3K27me3) in the ANK1 gene in entorhinal cortex from donors with high (n = 59) or low (n = 29) Alzheimer"s disease pathology.	Lysine	83-89	ankyrin 1	Homo sapiens	127-131
33097091-2	2020	The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a reader of lysine 9 di- and tri-methylation on histone H3 (H3K9me2/me3) and, more recently, lysine 126 di- and tri-methylation on DNA ligase 1 (LIG1K126me2/me3).	Lysine	157-163	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	33-38
32679234-6	2020	The interaction between miR-93-5p and lysine (K)-specific demethylase 6B (KDM6B) was identified using dual-luciferase reporter assay, and ChIP was used to validate the relationship between KDM6B and tumor necrosis factor-alpha (TNF-alpha).	Lysine	38-44	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	74-79
33033262-2	2020	Here, we demonstrate that the histone H3 lysine 27 trimethylation (H3K27me3) demethylase JMJD3 plays conflicting roles in mouse reprogramming.	Lysine	41-47	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	89-94
33023569-7	2020	Second, the 203 DMRs were enriched in epigenetic marks corresponding to enhancer regions, including monomethylation of lysine 4 and acetylation of lysine 27 of histone H3 (respectively H3K4me1 and H3K27ac).	Lysine	147-153	histone H3.3	Nicotiana tabacum	160-170
16805798-8	2006	Upon transfection of hippocampal neurones with an enzymatically inactive mutant of TACE, NCAM-stimulated neurite outgrowth was inhibited without affecting neurite outgrowth on poly-l-lysine, showing that proteolytic processing of NCAM by the metalloprotease TACE is involved in NCAM-mediated neurite outgrowth.	Lysine	176-189	ADAM metallopeptidase domain 17	Homo sapiens	83-87
34896750-0	2022	BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS.	Lysine	39-45	Bruton tyrosine kinase	Homo sapiens	0-3
32901907-3	2020	KDM2A and KDM2B (Lysine (K)-specific demethylase 2A / B) are histone demethylases modulating the accessibility of ribosomal genes, thereby regulating their transcription.	Lysine	17-23	lysine demethylase 2A	Homo sapiens	0-5
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	41-47	nuclear receptor coactivator 3	Mus musculus	170-176
34968781-4	2022	The results showed that aa 2491-2580 affected the degradation of BRCA2, especially lysine (Lys) 2497.	Lysine	83-89	BRCA2 DNA repair associated	Homo sapiens	65-70
34968781-4	2022	The results showed that aa 2491-2580 affected the degradation of BRCA2, especially lysine (Lys) 2497.	Lysine	91-94	BRCA2 DNA repair associated	Homo sapiens	65-70
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	nuclear receptor coactivator 3	Mus musculus	170-176
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	nuclear receptor coactivator 3	Mus musculus	170-176
34922149-0	2022	The lysine at position 151 of the duck hepatitis A virus 1 2C protein is critical for its NTPase activities.	Lysine	4-10	inosine triphosphatase	Homo sapiens	90-96
32666581-1	2020	Diagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable diagnostic tool.	Lysine	200-206	embryonic ectoderm development	Homo sapiens	143-146
34922149-7	2022	These results indicate that lysine at position 151 of the DHAV-1 2C protein is very important for NTPase activity.	Lysine	28-34	inosine triphosphatase	Homo sapiens	98-104
34922149-8	2022	Here, we demonstrated and partially characterized that the DHAV-1 2C protein has NTPase activity and showed that mutation of the lysine in the conserved Walker A impairs that activity.	Lysine	129-135	inosine triphosphatase	Homo sapiens	81-87
34974029-4	2022	We revealed that the activity of the fusion gene chimera EWSR1-FLI1, the genetic driver of Ewing sarcoma, leads to lower expression of the gene SPARC in these tumors, likely due to enriched acetylation marks of the histone H3 lysine 27 at regions including the SPARC promoter and potential enhancers.	Lysine	226-232	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	63-67
32892476-4	2020	We profiled the transcriptome using RNA-sequencing (N = 3/time-point) and genome-wide trimethylation of lysine 4 of histone H3 (H3K4me3; an active transcription marker) using chromatin immunoprecipitation and sequencing (ChIP-Seq; N = 2/time-point).	Lysine	104-110	H3 clustered histone 7	Mus musculus	116-126
34957905-6	2021	Direct DNA sequencing of the beta-globin gene revealed heterozygosity for a missense mutation at codon 59 (AAG>ATG), causing a lysine to methionine substitution (beta59(E3)Lys Met; HBB: c.179A>T).	Lysine	127-133	N-methylpurine DNA glycosylase	Homo sapiens	107-110
34957905-6	2021	Direct DNA sequencing of the beta-globin gene revealed heterozygosity for a missense mutation at codon 59 (AAG>ATG), causing a lysine to methionine substitution (beta59(E3)Lys Met; HBB: c.179A>T).	Lysine	172-175	N-methylpurine DNA glycosylase	Homo sapiens	107-110
34966788-3	2021	Mounting experiment evidence demonstrated the acetylation of a single-lysine residue K280 in the PHF6* was a critical event for the formation of pathological Tau amyloid deposits.	Lysine	70-76	PHD finger protein 6	Homo sapiens	97-101
32879443-5	2020	We demonstrated that knockdown of JMJD8 increased the interaction of SETDB1 and phosphoinositide-dependent kinase 1 (PDK1) with AKT1 and resulted in enhanced trimethylation of AKT1 at lysine 142 (K142), which is crucial for cell membrane recruitment, phosphorylation, and activation of AKT.	Lysine	184-190	pyruvate dehydrogenase kinase 1	Homo sapiens	117-121
32970693-5	2020	In this study, we identified a functional putative nuclear localization signal (NLS) of PNKP located in the linker region, and showed that lysine 138 (K138), arginine 139 (R139) and arginine 141 (R141) residues therein are critically important for nuclear localization.	Lysine	139-145	polynucleotide kinase 3'-phosphatase	Homo sapiens	88-92
32885980-4	2020	Such an open-form conformation is utilized to recognize lysine 142 methylated DNMT1, a cosolvent, and an NMR fragment screening hit, respectively, as revealed by the complex crystal structures.	Lysine	56-62	DNA methyltransferase 1	Homo sapiens	78-83
34569136-0	2021	Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors.	Lysine	57-63	coactivator associated arginine methyltransferase 1	Homo sapiens	104-109
34569136-3	2021	In this study, (bio)chemical and structural approaches were applied to specifically probe the impact of acetylation of Lys 18 in the histone H3 tail peptide on peptide recognition by the protein methyltransferase CARM1.	Lysine	119-122	coactivator associated arginine methyltransferase 1	Homo sapiens	213-218
34569136-6	2021	While the co-crystal structures reveal that lysine acetylation results in minor conformational differences for both CARM1 and the H3 peptide, acetylation of Lys 18 does lead to additional interactions (Van der Waals and hydrogen bonding) and likely reduces the cost of desolvation upon binding, resulting in increased affinity.	Lysine	44-50	coactivator associated arginine methyltransferase 1	Homo sapiens	116-121
34569136-8	2021	These findings provide new insights both into the mechanism of crosstalk between arginine methylation and lysine acetylation and inform the design of potent peptidomimetic CARM1 inhibitors.	Lysine	106-112	coactivator associated arginine methyltransferase 1	Homo sapiens	172-177
32387364-4	2020	In order to increase the OTE, human adult Hb (HbA) was subjected to triple modifications, i.e., alphaalpha-fumaryl crosslink at Lys-99(alpha), carboxymethylation at Val-1(alpha) and 8-arm PEG-based polymerization.	Lysine	128-131	keratin 90, pseudogene	Homo sapiens	46-49
34893559-2	2022	Histone 3 lysine 4 (H3K4) methylation at promoters is deposited by SET1 family methyltransferases acting within conserved multiprotein complexes known as COMPASS.	Lysine	10-16	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	67-71
32387364-5	2020	Crosslink at Lys-99(alpha) and carboxymethylation at Val-1(alpha) synergistically led to a T-like quaternary structure of HbA.	Lysine	13-16	keratin 90, pseudogene	Homo sapiens	122-125
32911802-1	2020	Deposition of histone H3 lysine 4 (H3K4) methylation at promoters is catalyzed by the SET1/COMPASS complex and is associated with context-dependent effects on gene expression and local changes in chromatin organization.	Lysine	25-31	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	86-90
34925656-1	2021	Background: Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.	Lysine	12-18	lysine demethylase 1A	Homo sapiens	44-49
34963932-0	2021	Novel Lysine-Rich Delivery Peptides of Plant Origin ERD and Human S100: The Effect of Carboxyfluorescein Conjugation, Influence of Aromatic and Proline Residues, Cellular Internalization, and Penetration Ability.	Lysine	6-12	S100 calcium binding protein A4	Homo sapiens	66-70
34418551-3	2021	Here we show that Arabidopsis UBC13A and UBC13B, the major drivers of lysine 63 (K63)-linked polyubiquitination, directly interact with PARPs/PARGs.	Lysine	70-76	ubiquitin-conjugating enzyme 36	Arabidopsis thaliana	41-47
32843577-9	2020	We show that Fe65 relies on the lysine acetyltransferase Tip60 for nuclear translocation.	Lysine	32-38	amyloid beta precursor protein binding family B member 1	Homo sapiens	13-17
34860858-12	2021	Taken together, our study demonstrated that the KAT ActG could induce the acetylation of GtfB and GtfC enzymatically in S. mutans, providing insights into the function of lysine acetylation in bacterial virulence and pathogenicity.	Lysine	171-177	actin, gamma 1	Rattus norvegicus	52-56
32843577-9	2020	We show that Fe65 relies on the lysine acetyltransferase Tip60 for nuclear translocation.	Lysine	32-38	lysine acetyltransferase 5	Homo sapiens	57-62
32906688-1	2020	Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates genes involved in cell lineage and differentiation through methylating lysine 27 on histone H3 (H3K27me3).	Lysine	210-216	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	59-63
34688635-2	2021	Here, we first revealed the role of histone lysine-specific demethylase 5D (KDM5D) in CRC in males.	Lysine	44-50	lysine demethylase 5D	Homo sapiens	76-81
32785353-3	2020	In the AnK peptide system (A = alanine, K = lysine), a structural transition from tubes to ribbons has been shown to occur upon an increase of the peptide length, n, from 6 to 8.	Lysine	44-50	ankyrin 1	Homo sapiens	7-10
34601098-4	2021	The lysine 312 residue (K312) was selected as the target site in ANXA1 because it is associated with SIRT2, and its mimic (K312Q) and silent (K312R) mutants were then established through site mutagenesis.	Lysine	4-10	annexin A1	Homo sapiens	65-70
34396798-0	2021	Lysine-specific demethylase 1 induced epithelial-mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway.	Lysine	0-6	jagged canonical Notch ligand 1	Rattus norvegicus	108-116
32943985-10	2020	XIST promoted methylation of histone H3 methylation at lysine 4 by enhancing the stability of lysine (K)-specific methyltransferase 2C (KMT2C) mRNA.	Lysine	55-61	inactive X specific transcripts	Mus musculus	0-4
34767799-9	2021	A specific arginine-to-lysine change in the highest affinity cyclic peptide reduced TAR binding by 10-fold, suggesting that TBP-derived cyclic peptides use an arginine-fork motif to recognize the TAR major-groove while differentiating the mode of binding from other TAR-targeting molecules.	Lysine	23-29	TATA-box binding protein	Homo sapiens	124-127
32943985-10	2020	XIST promoted methylation of histone H3 methylation at lysine 4 by enhancing the stability of lysine (K)-specific methyltransferase 2C (KMT2C) mRNA.	Lysine	94-100	inactive X specific transcripts	Mus musculus	0-4
34885830-1	2021	Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase.	Lysine	69-75	dihydroorotase	Saccharomyces cerevisiae S288C	0-14
32822602-1	2020	KAT5 encodes an essential lysine acetyltransferase, previously called TIP60, which is involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and cell proliferation; but it remains unclear whether variants in this gene cause a genetic disease.	Lysine	26-32	lysine acetyltransferase 5	Homo sapiens	0-4
32822602-1	2020	KAT5 encodes an essential lysine acetyltransferase, previously called TIP60, which is involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and cell proliferation; but it remains unclear whether variants in this gene cause a genetic disease.	Lysine	26-32	lysine acetyltransferase 5	Homo sapiens	70-75
32139900-8	2020	In addition, lysine 418 (K418) and lysine 249 (K249) were shown to be of critical importance in regulating PARP1 ubiquitination and degradation by WWP2.	Lysine	13-19	WW domain containing E3 ubiquitin protein ligase 2	Rattus norvegicus	147-151
34885830-1	2021	Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase.	Lysine	69-75	dihydroorotase	Saccharomyces cerevisiae S288C	16-22
34837126-9	2022	Furthermore, we observed that LPS treatment cannot cause ubiquitination of the lysine site (K105 and K144) mutant of FTL.	Lysine	79-85	ferritin light polypeptide 1	Mus musculus	117-120
32139900-8	2020	In addition, lysine 418 (K418) and lysine 249 (K249) were shown to be of critical importance in regulating PARP1 ubiquitination and degradation by WWP2.	Lysine	35-41	WW domain containing E3 ubiquitin protein ligase 2	Rattus norvegicus	147-151
34696588-6	2021	It is found that the process of transimination involving serine and PLP at the active site of the SHMT enzyme takes place through different elementary steps such as the formation of the first geminal diamine intermediate (GDI1), transfer of a proton from the substrate serine to the phenolic oxygen of PLP, followed by another proton transfer from PLP to the amine nitrogen of lysine with the formation of the second geminal diamine intermediate (GDI2), and finally, detachment of the active site lysine residue from PLP to produce the external aldimine.	Lysine	377-383	GDP dissociation inhibitor 2	Homo sapiens	447-451
32166393-1	2020	The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types.	Lysine	139-145	solute carrier family 6 member 14	Homo sapiens	4-37
32166393-1	2020	The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types.	Lysine	139-145	solute carrier family 6 member 14	Homo sapiens	39-46
34803610-2	2021	SETD1A is a chromatin remodeler that influences gene expression through the modulation of mono- di- and trimethylation marks on Histone-H3-Lysine-4 (H3K4me1/2/3).	Lysine	139-145	H3 clustered histone 7	Mus musculus	128-138
32586983-1	2020	Pygopus 2 (Pygo2) is a coactivator of Wnt/beta-catenin signaling that can bind bi- or trimethylated lysine 4 of histone-3 (H3K4me2/3) and participate in chromatin reading and writing.	Lysine	100-106	catenin (cadherin associated protein), beta 1	Mus musculus	42-54
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	84-90	lysine acetyltransferase 2A	Homo sapiens	251-256
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	84-90	lysine acetyltransferase 5	Homo sapiens	269-273
34331108-15	2021	Interestingly, significant reduction in total histone 3 acetylation and on specific lysine residues (lysine 9, 14, 18, and 27 on histone 3) was associated with significant protein downregulation of a series of lysine acetyltransferases (KAT3A, KAT3B, KAT2A, KAT2B, and KAT5).	Lysine	210-216	lysine acetyltransferase 2A	Homo sapiens	251-256
32592127-7	2020	Analyses of binding dynamics revealed that the variant Lysine-35 mediated consistent high-affinity interactions with C13 at the allosteric site, possibly forming the molecular basis of the selectivity of C13 as well as its high binding free energy as estimated.	Lysine	55-61	homeobox C13	Homo sapiens	117-120
34619147-1	2021	Unique among metazoan repressive histone methyltransferases, G9a and GLP, which chiefly target histone 3 lysine 9 (H3K9), require dimerization for productive H3K9 mono (me1)- and dimethylation (me2) in vivo.	Lysine	105-111	euchromatic histone lysine methyltransferase 2	Homo sapiens	61-64
32592127-7	2020	Analyses of binding dynamics revealed that the variant Lysine-35 mediated consistent high-affinity interactions with C13 at the allosteric site, possibly forming the molecular basis of the selectivity of C13 as well as its high binding free energy as estimated.	Lysine	55-61	homeobox C13	Homo sapiens	204-207
32236560-3	2020	We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on Histone H2A (H2AK119ub1), a Polycomb repressive mark.	Lysine	113-119	ASXL transcriptional regulator 1	Homo sapiens	25-30
34409953-10	2021	LINC01232 epigenetically repressed the KLF2 expression via binding to enhancer of EZH2, EZH2 was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	82-86
34409953-10	2021	LINC01232 epigenetically repressed the KLF2 expression via binding to enhancer of EZH2, EZH2 was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	165-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	88-92
32747680-3	2020	The enzymatic activity of MOF, PCAF and GCN5 acetyltransferases towards histone peptides bearing lysine analogs was evaluated using MALDI-TOF MS assays.	Lysine	97-103	lysine acetyltransferase 2A	Homo sapiens	40-44
34859147-2	2021	Using chromatin state profiling we identify an association of NRAS-mutants with bivalent Histone H3 lysine 27 trimethylation (H3K27me3) and broad H3K4me3 domains.	Lysine	100-106	NRAS proto-oncogene, GTPase	Homo sapiens	62-66
32324922-2	2020	Among the numerous chromatin modifiers identified in Arabidopsis (Arabidopsis thaliana), MORF RELATED GENE 1 (MRG1) and MRG2 have redundant functions in reading histone H3 lysine 36 trimethylation (H3K36me3).	Lysine	172-178	MRG family protein	Arabidopsis thaliana	120-124
34831074-6	2021	Moreover, the pattern of trimethylation of histone H3 lysine-27 is affected by NHA9, again in an RB-dependent manner.	Lysine	54-60	RB transcriptional corepressor 1	Mus musculus	97-99
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	Lysine	186-192	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	45-51
34681949-2	2021	The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation.	Lysine	151-157	euchromatic histone lysine methyltransferase 2	Homo sapiens	4-81
34681949-2	2021	The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation.	Lysine	151-157	euchromatic histone lysine methyltransferase 2	Homo sapiens	83-88
34681759-7	2021	Furthermore, KDM7A overexpression decreased the enrichment of di-methylation of histone H3 lysine 9 (H3K9me2) and H3 lysine 27 (H3K27me2) on the promoter of DGAT2.	Lysine	91-97	lysine (K)-specific demethylase 7A	Mus musculus	13-18
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	Lysine	228-234	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	45-51
32690000-1	2020	BACKGROUND: The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.	Lysine	143-149	CREB binding protein	Mus musculus	43-63
32690000-1	2020	BACKGROUND: The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.	Lysine	143-149	CREB binding protein	Mus musculus	65-68
32651355-8	2020	Mechanistically, LINC01446 could widely interact with histone lysine-specific demethylase LSD1 and recruit LSD1 to the Ras-related dexamethasone-induced 1 (RASD1) promoter, thereby suppressing RASD1 transcription.	Lysine	62-68	lysine demethylase 1A	Homo sapiens	90-94
34681759-7	2021	Furthermore, KDM7A overexpression decreased the enrichment of di-methylation of histone H3 lysine 9 (H3K9me2) and H3 lysine 27 (H3K27me2) on the promoter of DGAT2.	Lysine	117-123	lysine (K)-specific demethylase 7A	Mus musculus	13-18
32459093-6	2020	DS@MA-LS was designed to prolong blood circulation and deshield PEG shell under MMP2 cleavage to expose lysine and target overexpressed ATB0,+ for enhanced tumor distribution and cancer cellular uptake.	Lysine	104-110	solute carrier family 1 member 5	Homo sapiens	136-140
34610305-5	2021	Manipulation of broad histone marks and enhancer elements by overexpressing the histone H3 lysine 9/36 tri-demethylase KDM4A impacts RT across 11% of the genome.	Lysine	91-97	lysine demethylase 4A	Homo sapiens	119-124
32378752-6	2020	By binding to a component of the epigenetic modification complex enhancer of zeste homolog 2 (EZH2), ANRIL could maintain lysine residue 27 of histone 3 (H3K27me3) levels in the promoter of ERBB receptor feedback inhibitor 1 (ERRFI1), which is a tumour suppressor gene in CCA.	Lysine	122-128	CDKN2B antisense RNA 1	Homo sapiens	101-106
34303036-0	2021	Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9.	Lysine	21-27	matrix metallopeptidase 9	Homo sapiens	108-113
34303036-6	2021	The synthesized biphenyl substituted lysine derivatives showed IC50-values in the low nanomolar concentration range against MMP-2 (ligands 3a-d: 3 nM to 8 microM, ligands 4a-d: 45 nM to 350 microM) and low micromolar range against MMP-9 (ligands 3a-d: 350 nM to 60 microM, ligands 4a-d: 5 microM to 600 microM), with a selectivity up to more than 160-fold for MMP-2.	Lysine	37-43	matrix metallopeptidase 9	Homo sapiens	231-236
32379508-4	2020	Inhibition of an epigenetic enzyme is a potential treatment of cSCC.Areas covered: We provide an overview of the development of inhibitors targeting the lysine demethylase, LSD1 (KDM1A), the first histone demethylase discovered.	Lysine	153-159	lysine demethylase 1A	Homo sapiens	179-184
34498354-0	2021	The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development.	Lysine	4-10	SET domain containing 2	Gallus gallus	29-34
34498354-1	2021	SETD2 is a histone H3 lysine 36 (H3K36) tri-methylase that is upregulated in response to neural crest induction.	Lysine	22-28	SET domain containing 2	Gallus gallus	0-5
32376690-7	2020	Accordingly, GCN5- and HAT1-catalyzed acetylation of specific lysine residues on histones H3 and H4 was stimulated by polyamines.	Lysine	62-68	K(lysine) acetyltransferase 2A	Mus musculus	13-17
34498354-7	2021	These results suggest that SETD2 activity is essential for early neural crest development, further demonstrating that lysine methylation is an important mechanism regulating the neural crest.	Lysine	118-124	SET domain containing 2	Gallus gallus	27-32
34155695-6	2021	The H3 lysine residues influenced by ACLY were in accordance with GCN5 targets, using GCN5 knock-down and overexpression we showed that ACLY and GCN5 functioned in the same pathway for histone H3 acetylation.	Lysine	7-13	ATP citrate lyase	Homo sapiens	37-41
32318688-3	2020	We engineered bovine embryonic fibroblasts (BEFs) for the doxycycline-inducible expression of a biologically active, truncated form of murine Kdm4b, a demethylase that removes histone 3 lysine 9 trimethylation (H3K9me3) and H3K36me3 marks.	Lysine	186-192	lysine (K)-specific demethylase 4B	Mus musculus	142-147
34473995-5	2021	Here we demonstrate that the BD of Caenorhabditis elegans SMARCA4/BRG1, a core SWI/SNF subunit, recognizes acetylated lysine 14 of histone H3 (H3K14ac), similar to its Homo sapiens ortholog.	Lysine	118-124	Histone H3	Caenorhabditis elegans	131-141
32459472-5	2020	Here, using the lysine reactive mass spectrometry cleavable cross-linker DSSO, we found that the C-terminal domain of the Arabidopsis H+-ATPase 2 (AHA2) cross-linked extensively with the actuator, nucleotide-binding, and phosphorylation domains, suggesting that the C-terminal domain regulates the catalytic cycle by modulating the relative positions of these domains.	Lysine	16-22	H[+]-ATPase 2	Arabidopsis thaliana	134-145
32459472-5	2020	Here, using the lysine reactive mass spectrometry cleavable cross-linker DSSO, we found that the C-terminal domain of the Arabidopsis H+-ATPase 2 (AHA2) cross-linked extensively with the actuator, nucleotide-binding, and phosphorylation domains, suggesting that the C-terminal domain regulates the catalytic cycle by modulating the relative positions of these domains.	Lysine	16-22	H[+]-ATPase 2	Arabidopsis thaliana	147-151
34630544-1	2021	Dihydroorotase (DHOase) possesses a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine.	Lysine	130-136	dihydroorotase	Saccharomyces cerevisiae S288C	0-14
32636834-8	2020	We have also found lysine residues in FOXP3 required for MDM2-mediated ubiquitination.	Lysine	19-25	MDM2 proto-oncogene	Homo sapiens	57-61
34630544-1	2021	Dihydroorotase (DHOase) possesses a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine.	Lysine	130-136	dihydroorotase	Saccharomyces cerevisiae S288C	16-22
34650987-2	2021	In Drosophila, CBP mediated acetylation of histone H3 lysine 27 (H3K27ac) is a known hallmark of gene activation regulated by trithorax group proteins (trxG).	Lysine	54-60	nejire	Drosophila melanogaster	15-18
32371394-1	2020	Sirtuins (e.g., human Sirt1-7) catalyze the removal of acyl groups from lysine residues in proteins in an NAD+-dependent manner, and loss of sirtuin deacylase activity correlates with the development of aging-related diseases.	Lysine	72-78	sirtuin 1	Homo sapiens	22-29
34573442-4	2021	ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs.	Lysine	141-147	ATP citrate lyase	Homo sapiens	0-17
34573442-4	2021	ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs.	Lysine	141-147	ATP citrate lyase	Homo sapiens	19-23
32542505-1	2020	BACKGROUND: Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues.	Lysine	141-147	elastin	Canis lupus familiaris	120-127
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	Lysine	148-154	dihydrolipoamide S-succinyltransferase	Homo sapiens	61-65
34551331-7	2022	These highlight retained protein backbone integrity in collagen and elastin whilst Lys"s ability to form several imine bonded Lys-Lys species suggests striking similarities to crosslinking via lysyloxidase catalysis in vivo.	Lysine	83-86	elastin	Homo sapiens	68-75
33173715-1	2020	Microbial rhodopsin is a large family of membrane proteins having seven transmembrane helices (TM1-7) with an all-trans retinal (ATR) chromophore that is covalently bound to Lys in the TM7.	Lysine	174-177	tropomyosin 3	Homo sapiens	95-100
34604175-4	2021	We previously showed site-specific acetylation at three different lysine residues increases TrxR1 activity by reducing the levels of linked dimers and low activity TrxR1 tetramers.	Lysine	66-72	thioredoxin reductase 1	Homo sapiens	92-97
32579679-11	2020	Generation of FDP-Lys and hydrogen peroxide increased in TR-MUL5 cells under hypoxic condition, which was abrogated by SMOX inhibitor MDL72527.	Lysine	18-21	spermine oxidase	Rattus norvegicus	119-123
34604175-4	2021	We previously showed site-specific acetylation at three different lysine residues increases TrxR1 activity by reducing the levels of linked dimers and low activity TrxR1 tetramers.	Lysine	66-72	thioredoxin reductase 1	Homo sapiens	164-169
34604175-7	2021	Mass spectrometry confirmed aspirin-induced acetylation at multiple lysine residues in TrxR1.	Lysine	68-74	thioredoxin reductase 1	Homo sapiens	87-92
34495967-2	2021	ALDH7A1 encodes alpha-aminoadipic semialdehyde dehydrogenase in lysine catabolism.	Lysine	64-70	aldehyde dehydrogenase 7 family member A1	Homo sapiens	0-7
34495967-2	2021	ALDH7A1 encodes alpha-aminoadipic semialdehyde dehydrogenase in lysine catabolism.	Lysine	64-70	aldehyde dehydrogenase 7 family member A1	Homo sapiens	16-60
32084453-3	2020	Jumonji domain-containing protein 3 (Jmjd3), a trimethylated lysine 27 in histone 3 (H3K27me3) demethylase, can be activated by nuclear factor-kappa B (NF-kappaB), further regulating the expression of pro-inflammatory cytokines and resulting in neuroinflammation.	Lysine	61-67	lysine demethylase 6B	Rattus norvegicus	0-35
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Lysine	68-71	C-X-C motif chemokine receptor 4	Homo sapiens	25-30
32084453-3	2020	Jumonji domain-containing protein 3 (Jmjd3), a trimethylated lysine 27 in histone 3 (H3K27me3) demethylase, can be activated by nuclear factor-kappa B (NF-kappaB), further regulating the expression of pro-inflammatory cytokines and resulting in neuroinflammation.	Lysine	61-67	lysine demethylase 6B	Rattus norvegicus	37-42
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Lysine	68-71	C-X-C motif chemokine receptor 4	Homo sapiens	159-164
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Lysine	68-71	C-X-C motif chemokine receptor 4	Homo sapiens	223-228
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	proteasome 26S subunit, non-ATPase 14	Homo sapiens	15-21
34400522-9	2021	Keap1 was required for viral induction of G9a-GLP lysine methyltransferase binding and H3K9me2 modification at cytokine genes.	Lysine	50-56	kelch-like ECH-associated protein 1	Mus musculus	0-5
32476569-4	2021	Deubiquitinase PSMD14/POH1 prevents IRF3 from autophagic degradation by cleaving the K27-linked poly-ubiquitin chains at lysine 313 on IRF3 to maintain its basal level and IRF3-mediated type I IFN activation.	Lysine	121-127	proteasome 26S subunit, non-ATPase 14	Homo sapiens	22-26
32528730-6	2020	In contrast, activation of SIRT1 increased autophagy in chondrocytes by the deacetylation of lysine residues on crucial autophagy proteins (Beclin1, ATG5, ATG7, LC3).	Lysine	93-99	sirtuin 1	Homo sapiens	27-32
34456745-6	2021	Mass spectrometry analyses identified lysine 166 (K166) in Rac1 as a residue targeted by SIRT1.	Lysine	38-44	Rac family small GTPase 1	Homo sapiens	59-63
34456745-6	2021	Mass spectrometry analyses identified lysine 166 (K166) in Rac1 as a residue targeted by SIRT1.	Lysine	38-44	sirtuin 1	Homo sapiens	89-94
32528730-6	2020	In contrast, activation of SIRT1 increased autophagy in chondrocytes by the deacetylation of lysine residues on crucial autophagy proteins (Beclin1, ATG5, ATG7, LC3).	Lysine	93-99	beclin 1	Homo sapiens	140-147
34447387-3	2021	Similar to ubiquitin, ISG15 covalently conjugates to lysine residues in substrate proteins in a process called ISGylation.	Lysine	53-59	ISG15 ubiquitin-like modifier	Mus musculus	22-27
32528730-6	2020	In contrast, activation of SIRT1 increased autophagy in chondrocytes by the deacetylation of lysine residues on crucial autophagy proteins (Beclin1, ATG5, ATG7, LC3).	Lysine	93-99	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	161-164
32466590-1	2020	The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells.	Lysine	39-45	Myb like, SWIRM and MPN domains 1	Homo sapiens	53-59
34088988-3	2021	In preliminary studies, we found that KDM4A (lysine-specific histone demethylase 4) was overexpressed in MPM.	Lysine	45-51	lysine demethylase 4A	Homo sapiens	38-43
32466590-1	2020	The deubiquitination of histone H2A on lysine 119 by 2A-DUB/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells.	Lysine	39-45	Myb like, SWIRM and MPN domains 1	Homo sapiens	60-65
34289358-2	2021	Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRAS mutants with bivalent histone H3 lysine 27 trimethylation (H3K27me3) and Polycomb repressive complex 2.	Lysine	127-133	NRAS proto-oncogene, GTPase	Homo sapiens	89-93
32453339-3	2020	In this study, we found that the enhancer of zeste homolog 2 (EZH2), which catalyzes the methylation at lysine 27 of histone H3, is a target of USP7 and is stabilized by USP7-mediated deubiquitination.	Lysine	104-110	ubiquitin specific peptidase 7	Homo sapiens	144-148
34252134-7	2021	Similarly, we introduced lysine-to-arginine mutations in constitutively active Rac1 to inhibit site-specific ubiquitination and analyze this effect on Rac1 signaling output and ubiquitination.	Lysine	25-31	Rac family small GTPase 1	Homo sapiens	79-83
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	113-119	CREB binding protein	Mus musculus	82-85
32453339-3	2020	In this study, we found that the enhancer of zeste homolog 2 (EZH2), which catalyzes the methylation at lysine 27 of histone H3, is a target of USP7 and is stabilized by USP7-mediated deubiquitination.	Lysine	104-110	ubiquitin specific peptidase 7	Homo sapiens	170-174
32477007-11	2020	EZH2-mediated histone 3 trimethylated on lysine 27 (H3K27me3), a marker of silent chromatin conformation, at the FOSB promoter inhibited it expression.	Lysine	41-47	FBJ osteosarcoma oncogene B	Mus musculus	113-117
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	113-119	E1A binding protein p300	Mus musculus	90-94
32490171-4	2020	Therefore, miR-155 inhibits the methylation modification of histone H3 on the 27th lysine.	Lysine	83-89	microRNA 155	Homo sapiens	11-18
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	225-231	CREB binding protein	Mus musculus	82-85
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	225-231	E1A binding protein p300	Mus musculus	90-94
34217316-1	2021	The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3).	Lysine	124-130	lysine demethylase 6B	Homo sapiens	4-39
29185849-4	2020	Monoubiquitylation of KRAS at lysine 147 (mUbRAS) enhances Ras activation and promotes signaling through the RAF and Phosphoinositide 3-Kinase (PI3K) signaling pathways.	Lysine	30-36	KRAS proto-oncogene, GTPase	Homo sapiens	22-26
34217316-1	2021	The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3).	Lysine	124-130	lysine demethylase 6B	Homo sapiens	41-46
34156114-5	2021	More importantly, GCN5 could mediate SOX9 acetylation at lysine 62 (K62) to enhance SOX9 binding to FGF1 or PDGFalpha promoter and promote FGF1 or PDGFalpha synthesis and GMC proliferation.	Lysine	57-63	SRY-box transcription factor 9	Rattus norvegicus	37-41
34156114-5	2021	More importantly, GCN5 could mediate SOX9 acetylation at lysine 62 (K62) to enhance SOX9 binding to FGF1 or PDGFalpha promoter and promote FGF1 or PDGFalpha synthesis and GMC proliferation.	Lysine	57-63	SRY-box transcription factor 9	Rattus norvegicus	84-88
32496146-9	2020	Majority of BPA analogs interacted with TBG forming a salt bridge interaction at Lys-270.	Lysine	81-84	serpin family A member 7	Homo sapiens	40-43
34267496-10	2021	We identified that EPHA2 rs137853199 is degraded via the ubiquitin-proteasomal pathway through a lysine-48 (K48) residue linkage.	Lysine	97-103	EPH receptor A2	Homo sapiens	19-24
32242892-2	2020	The substrate binding site of ASCT2 was proposed to be specific for small amino acids with neutral side chains, excluding basic substrates such as lysine.	Lysine	147-153	solute carrier family 1 member 5	Homo sapiens	30-35
34447288-10	2021	ANGPTL4, aurora kinase A (AURKA), a mitotic kinase, and Tat-interacting protein p60 kDa (Tip60), a lysine acetyltransferase, associated with chromatin in the ANGPTL4 overexpressing cells but not in cells that expressed endogenous levels of ANGPTL4.	Lysine	99-105	lysine acetyltransferase 5	Homo sapiens	56-87
34447288-10	2021	ANGPTL4, aurora kinase A (AURKA), a mitotic kinase, and Tat-interacting protein p60 kDa (Tip60), a lysine acetyltransferase, associated with chromatin in the ANGPTL4 overexpressing cells but not in cells that expressed endogenous levels of ANGPTL4.	Lysine	99-105	lysine acetyltransferase 5	Homo sapiens	89-94
32242892-4	2020	Therefore, we tested whether basic amino acids with side chains shorter than lysine can interact with the ASCT2 binding site.	Lysine	77-83	solute carrier family 1 member 5	Homo sapiens	106-111
32352380-3	2020	PRDM9 subsequently catalyzes tri-methylation of lysine 4 and lysine 36 of Histone H3 in nearby nucleosomes.	Lysine	48-54	PR domain containing 9	Mus musculus	0-5
34080430-6	2021	Molecular dynamics simulation revealed that both Nb10 and TiNb9 bind to native S100A9 homo-dimer by forming ionic interactions with the positively charged Lys residue-rich patches on the protein surface.	Lysine	155-158	S100 calcium binding protein A9	Homo sapiens	79-85
34194459-3	2021	Here we reveal the functions of two Arabidopsis thaliana homologs of human lysine-specific demethylase1-like1, LDL1 and LDL2, in the maintenance of methyl groups at lysine 4 of histone H3 and in plant immunity to Pseudomonas syringae infection.	Lysine	75-81	LSD1-like2	Arabidopsis thaliana	120-124
34194459-3	2021	Here we reveal the functions of two Arabidopsis thaliana homologs of human lysine-specific demethylase1-like1, LDL1 and LDL2, in the maintenance of methyl groups at lysine 4 of histone H3 and in plant immunity to Pseudomonas syringae infection.	Lysine	165-171	LSD1-like2	Arabidopsis thaliana	120-124
32352380-3	2020	PRDM9 subsequently catalyzes tri-methylation of lysine 4 and lysine 36 of Histone H3 in nearby nucleosomes.	Lysine	61-67	PR domain containing 9	Mus musculus	0-5
32352380-3	2020	PRDM9 subsequently catalyzes tri-methylation of lysine 4 and lysine 36 of Histone H3 in nearby nucleosomes.	Lysine	61-67	H3 clustered histone 7	Mus musculus	74-84
32035039-3	2020	Microbial transglutaminase (mTG) that catalyzes isopeptide bond formation between proteinaceous or peptidic glutamines and lysines, provides many favorable properties that are beneficial for the manufacturing of these conjugates.	Lysine	123-130	protease, serine 3	Mus musculus	28-31
34322674-4	2021	Fibrotic remodeling depends on deposition and crosslinking of collagen by lysyl oxidase (LOX), an enzyme that catalyzes the deamination of lysine and hydroxylysine residues, facilitating intra/intermolecular covalent bonds.	Lysine	139-145	lysyl oxidase	Homo sapiens	74-87
34322674-4	2021	Fibrotic remodeling depends on deposition and crosslinking of collagen by lysyl oxidase (LOX), an enzyme that catalyzes the deamination of lysine and hydroxylysine residues, facilitating intra/intermolecular covalent bonds.	Lysine	139-145	lysyl oxidase	Homo sapiens	89-92
34973011-2	2021	In previous work, we reported that the circadian transcription factor CLOCK and its heterodimer partner BMAL1 suppress the transcriptional activity of the glucocorticoid receptor (GR) by acetylating a lysine cluster located in its hinge region between the DNA- and ligand-binding domains.	Lysine	201-207	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	104-109
32094206-3	2020	In this study, we demonstrate that Ezh2, which represses gene expression through methylation of histone 3 lysine 27, was essential for repression of numerous genes, including genes encoding innate lymphocyte transcription factors, specifically in murine B lymphocyte progenitors, but these cells maintained their B lymphocyte identity.	Lysine	106-112	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	35-39
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	SKI like proto-oncogene	Homo sapiens	69-73
34740826-7	2021	Our results indicate that lysine 343 localized in the SAND domain of SKIL constitutes a target for RNF111 ubiquitylation and demonstrate that RNF111 E3 ubiquitin ligase function specifically targets SKI and SKIL ubiquitylation and degradation upon TGF-beta pathway activation.	Lysine	26-32	SKI like proto-oncogene	Homo sapiens	207-211
32256210-2	2020	JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36).	Lysine	96-102	lysine demethylase 4A	Homo sapiens	0-6
32232156-5	2020	The stability and catalytic function of DUSP6 are maintained through conjugation of small ubiquitin-like modifier-1 (SUMO1) and SUMO2/3 at lysine-234 (K234), which is disrupted during oxidation through transcriptional up-regulation of SUMO-deconjugating enzyme, SENP1, causing DUSP6 degradation by ubiquitin-proteasome.	Lysine	139-145	dual specificity phosphatase 6	Mus musculus	277-282
35239138-2	2022	The trimethylation of histone H3 on lysine-27 (H3K27me3) is a critical epigenetic event that is controlled by Jumonji domain-containing protein-3 (JMJD3).	Lysine	36-42	lysine demethylase 6B	Homo sapiens	110-145
35239138-2	2022	The trimethylation of histone H3 on lysine-27 (H3K27me3) is a critical epigenetic event that is controlled by Jumonji domain-containing protein-3 (JMJD3).	Lysine	36-42	lysine demethylase 6B	Homo sapiens	147-152
32191225-2	2020	Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) to target SOX2-driven CSC in breast cancer.	Lysine	70-76	lysine demethylase 1A	Homo sapiens	101-105
35338668-7	2022	Chromatin immunoprecipitation assay revealed that L-theanine enhances acetylations of Lys-9 and Lys-14 residues of histone H3 within chromatin surrounding the promoter region of gp91-phox gene.	Lysine	86-89	cytochrome b-245 beta chain	Homo sapiens	178-187
35338668-7	2022	Chromatin immunoprecipitation assay revealed that L-theanine enhances acetylations of Lys-9 and Lys-14 residues of histone H3 within chromatin surrounding the promoter region of gp91-phox gene.	Lysine	96-99	cytochrome b-245 beta chain	Homo sapiens	178-187
32191225-2	2020	Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) to target SOX2-driven CSC in breast cancer.	Lysine	70-76	lysine demethylase 1A	Homo sapiens	106-111
32191225-2	2020	Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) to target SOX2-driven CSC in breast cancer.	Lysine	70-76	SRY-box transcription factor 2	Homo sapiens	145-149
35636128-0	2022	Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents.	Lysine	142-148	lysine demethylase 1A	Homo sapiens	173-177
32215184-1	2020	The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of MLL-rearranged leukemia.	Lysine	14-20	histamine N-methyltransferase	Homo sapiens	51-54
35590288-1	2022	BACKGROUND: Lysine-specific histone demethylase 3A (KDM3A) is a potent histone modifier that is frequently implicated in the progression of several malignancies.	Lysine	12-18	lysine (K)-specific demethylase 3A	Mus musculus	52-57
31948749-4	2020	In addition, we observed that WDR5 promoted the binding of Myc to CARM1 promoter by interacting with Myc and inducing histone 3 lysine 4 trimethylation (H3K4me3).	Lysine	128-134	coactivator associated arginine methyltransferase 1	Homo sapiens	66-71
35447080-0	2022	CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair.	Lysine	28-34	chromodomain Y like	Homo sapiens	0-5
35447080-3	2022	Here, we identify a CDYL1-dependent local decrease in the transcriptionally active marks histone lysine crotonylation (Kcr) and crotonylated lysine 9 of H3 (H3K9cr) at AsiSI-induced DSBs, which correlates with transcriptional silencing.	Lysine	97-103	chromodomain Y like	Homo sapiens	20-25
35447080-3	2022	Here, we identify a CDYL1-dependent local decrease in the transcriptionally active marks histone lysine crotonylation (Kcr) and crotonylated lysine 9 of H3 (H3K9cr) at AsiSI-induced DSBs, which correlates with transcriptional silencing.	Lysine	141-147	chromodomain Y like	Homo sapiens	20-25
32131390-1	2020	With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic lysine that play important roles in regulating epithelial ion transport.	Lysine	8-14	WNK lysine deficient protein kinase 1b	Danio rerio	22-26
35579947-5	2022	Mechanistically, hnRNPA1 bound with SUMO2 at the lysine 113 residue via KRASG12D-induced hyperactivation of SUMOylation, which enabled its interaction with TSG101 to enhance hnRNPA1 packaging and transmission via EVs.	Lysine	49-55	small ubiquitin like modifier 2	Homo sapiens	36-41
35634322-13	2022	Accordingly, EtOH-EVs were found to be enriched with mRNA for the euchromatin histone lysine methyltransferase (Ehm2t/G9a), an enzyme that reduces chromatin accessibility through histone-3 lysine-9 di-methylation (H3K9me2).	Lysine	189-195	euchromatic histone lysine methyltransferase 2	Homo sapiens	118-121
32131390-1	2020	With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic lysine that play important roles in regulating epithelial ion transport.	Lysine	122-128	WNK lysine deficient protein kinase 1b	Danio rerio	22-26
31726157-1	2020	The fabrication of an amperometric lysine biosensor is described in this study, wherein nanoparticles (NPs) of lysine oxidase (LOx) are covalently immobilized onto gold electrode (AuE).	Lysine	35-41	lysyl oxidase	Homo sapiens	111-125
35507647-5	2022	Mechanistically, we supported that extracellular AKG binds with a purinergic receptor, P2RX4, to initiate the solute carrier family 25 member 11 (SLC25A11)-dependent nucleus translocation of intracellular AKG and subsequently induces demethylation of lysine 27 on histone 3 (H3K27) in the seprina1e promoter region to decrease hepatic gluconeogenesis.	Lysine	251-257	solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11	Mus musculus	110-144
35507647-5	2022	Mechanistically, we supported that extracellular AKG binds with a purinergic receptor, P2RX4, to initiate the solute carrier family 25 member 11 (SLC25A11)-dependent nucleus translocation of intracellular AKG and subsequently induces demethylation of lysine 27 on histone 3 (H3K27) in the seprina1e promoter region to decrease hepatic gluconeogenesis.	Lysine	251-257	solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11	Mus musculus	146-154
31726157-1	2020	The fabrication of an amperometric lysine biosensor is described in this study, wherein nanoparticles (NPs) of lysine oxidase (LOx) are covalently immobilized onto gold electrode (AuE).	Lysine	35-41	lysyl oxidase	Homo sapiens	127-130
35513262-2	2022	(1) CBX2, a key component of the canonical PRC1 complex, is an epigenetic reader, recognizing trimethylated lysine on histone 3 (H3K27me3) (2) and is overexpressed in metastatic neuroendocrine prostate cancer.	Lysine	108-114	chromobox 2	Homo sapiens	4-8
31544977-8	2020	Mechanistically, AGG-induced cytoplasmic SIRT1 deacetylated a Lys residue on the cytoplasmic domain of lysosome-associated membrane protein 1 (LAMP1), an autolysosomal protein, resulting in lipophagy and senescence.	Lysine	62-65	sirtuin 1	Homo sapiens	41-46
32120841-5	2020	In the present study, we identified the specific NTD of RORalpha2 that enhances prostate tumor progression and proliferation via lysine methylation-mediated recruitment of coactivator complex pontin/Tip60.	Lysine	129-135	lysine acetyltransferase 5	Homo sapiens	199-204
35158021-9	2022	Mechanistically, SIRT1 interacts with heat shock 70 kDa protein 4 (HSPA4) and deacetylates it at 305, 351 and 605 lysine residues.	Lysine	114-120	heat shock protein 4	Mus musculus	38-65
35158021-9	2022	Mechanistically, SIRT1 interacts with heat shock 70 kDa protein 4 (HSPA4) and deacetylates it at 305, 351 and 605 lysine residues.	Lysine	114-120	heat shock protein 4	Mus musculus	67-72
32147995-1	2020	As a member of the histone lysine-specific demethylase family, KDM1A plays a pivotal role in biological processes including signal transduction, chromatin reprogramming, embryo development, hematopoiesis, glucose and lipid metabolism.	Lysine	27-33	lysine demethylase 1A	Homo sapiens	63-68
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	matrix metallopeptidase 9	Homo sapiens	222-247
35434944-12	2022	This recruited the WD repeat domain 5 (WDR5)/mixed-lineage leukemia (MLL) complex to increase the trimethylation of histone H3 at lysine 4 (H3K4me3); resulting in upregulation of lymphoid enhancer-binding factor 1 (LEF1), matrix metallopeptidase 9 (MMP9), C-C motif chemokine ligand 20 (CCL20), and E2F transcription factor 2 (E2F2).	Lysine	130-136	matrix metallopeptidase 9	Homo sapiens	249-253
35278430-1	2022	Jumonji domain-containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVF) has not been explored.	Lysine	58-64	lysine demethylase 6B	Homo sapiens	0-35
35278430-1	2022	Jumonji domain-containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVF) has not been explored.	Lysine	58-64	lysine demethylase 6B	Homo sapiens	37-42
32046321-5	2020	In this study, we designed engineered GOx, which was made readily available for single-step modification with a redox mediator (phenazine ethosulfate, PES) on its surface via a lysine residue rationally introduced into the enzyme.	Lysine	177-183	hydroxyacid oxidase 1	Homo sapiens	38-41
35472077-7	2022	Additional biochemical, cellular, proteomic, and genomic analyses demonstrated that ADPRylation of H2B-D51 inhibits p300-mediated acetylation of H2B at many Lys residues.	Lysine	157-160	E1A binding protein p300	Mus musculus	116-120
31914694-1	2020	Enhancer of zeste homolog 2 (EZH2), a well-known methyltransferase, mediates histone H3 lysine 27 trimethylation (H3K27me3) and plays a crucial role in several kidney disease models.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
35403872-6	2022	Mechanistically, we found that SMURF2 directly binds, ubiquitinates and stabilizes ADAR1p110 in an E3 ubiquitin ligase-dependent manner, through ADAR1p110 ubiquitination at lysine-744 (K744).	Lysine	173-179	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	31-37
35403872-6	2022	Mechanistically, we found that SMURF2 directly binds, ubiquitinates and stabilizes ADAR1p110 in an E3 ubiquitin ligase-dependent manner, through ADAR1p110 ubiquitination at lysine-744 (K744).	Lysine	173-179	Cbl proto-oncogene like 2	Homo sapiens	99-118
35119221-4	2022	Moreover, CDYL facilitates histone 3 lysine 27 trimethylation (H3K27me3) deposition at the Kcnb1 intron region thus silencing voltage-gated potassium channel (Kv ) subfamily member Kv 2.1 transcription.	Lysine	37-43	chromodomain protein, Y chromosome-like	Mus musculus	10-14
31914694-1	2020	Enhancer of zeste homolog 2 (EZH2), a well-known methyltransferase, mediates histone H3 lysine 27 trimethylation (H3K27me3) and plays a crucial role in several kidney disease models.	Lysine	88-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
31307234-1	2019	JHDM1A participates in cancer development via demethylate dimethyl histone H3 lysine 36 (H3K36me2).	Lysine	78-84	lysine demethylase 2A	Homo sapiens	0-6
35286850-9	2022	In this study, we developed a hyaluronic acid (HA)/poly-L-lysine (PLL) layer-by-layer (LbL) self-assembly coating on beta-TCP (beta-tricalcium phosphate) scaffolds providing immobilization of modularized engineered sEVs (with c(RGDfC) surface functionalization and ZEB1 loading) to facilitate bone defect regeneration under DM conditions.	Lysine	51-64	zinc finger E-box binding homeobox 1	Homo sapiens	265-269
31513837-12	2019	Among them, we confirmed that IRF4 is a downstream effector of the KDM3A-dependent pathway which could epigenetically influence the transcription of IRF4 by enhancing histone H3 lysine 9 di-methylation(H3K9me2) accumulation on the IRF4 gene proximal promoter region to modulate macrophage polarization.	Lysine	178-184	interferon regulatory factor 4	Rattus norvegicus	30-34
35487595-1	2022	Lysine specific demethylase 1 (LSD1), a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9, has become a potential therapeutic target for cancer therapy.	Lysine	125-131	lysine demethylase 1A	Homo sapiens	0-29
35487595-1	2022	Lysine specific demethylase 1 (LSD1), a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9, has become a potential therapeutic target for cancer therapy.	Lysine	125-131	lysine demethylase 1A	Homo sapiens	31-35
31513837-12	2019	Among them, we confirmed that IRF4 is a downstream effector of the KDM3A-dependent pathway which could epigenetically influence the transcription of IRF4 by enhancing histone H3 lysine 9 di-methylation(H3K9me2) accumulation on the IRF4 gene proximal promoter region to modulate macrophage polarization.	Lysine	178-184	lysine demethylase 3A	Rattus norvegicus	67-72
31513837-12	2019	Among them, we confirmed that IRF4 is a downstream effector of the KDM3A-dependent pathway which could epigenetically influence the transcription of IRF4 by enhancing histone H3 lysine 9 di-methylation(H3K9me2) accumulation on the IRF4 gene proximal promoter region to modulate macrophage polarization.	Lysine	178-184	interferon regulatory factor 4	Rattus norvegicus	149-153
35041077-1	2022	Mono-methylation of the fourth lysine on the N-terminal tail of histone H3 was found to support the induction of RNA polymerase II transcription in S. cerevisiae during nutrient stress.	Lysine	31-37	histone H3	Saccharomyces cerevisiae S288C	64-74
31513837-12	2019	Among them, we confirmed that IRF4 is a downstream effector of the KDM3A-dependent pathway which could epigenetically influence the transcription of IRF4 by enhancing histone H3 lysine 9 di-methylation(H3K9me2) accumulation on the IRF4 gene proximal promoter region to modulate macrophage polarization.	Lysine	178-184	interferon regulatory factor 4	Rattus norvegicus	149-153
35041077-2	2022	In S. cerevisiae, the mono-, di- and tri-methylation of lysine 4 on histone H3 (H3K4) is catalyzed by the protein methyltransferase, Set1.	Lysine	56-62	histone H3	Saccharomyces cerevisiae S288C	68-78
31550663-3	2019	Upon protein-protein interaction (PPI) between the catalytic subunit EZH2 and EED, PRC2 primarily methylates lysine 27 of histone H3 (H3K27me3), thus modulating the chromatin structure and inducing transcriptional repression.	Lysine	109-115	embryonic ectoderm development	Homo sapiens	78-81
31722219-3	2019	More importantly, CCDC84 acetylation oscillates throughout the cell cycle, and the acetylation state of CCDC84 at lysine 31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10.	Lysine	114-120	sirtuin 1	Homo sapiens	156-161
35279367-14	2022	TAKE- HOME MESSAGE: Early initiation of lysine reduction therapies adjunct to pyridoxine treatment in patients with PDE-ALDH7A1 may result in an improved neurodevelopmental outcome.	Lysine	40-46	aldehyde dehydrogenase 7 family member A1	Homo sapiens	116-119
35279367-14	2022	TAKE- HOME MESSAGE: Early initiation of lysine reduction therapies adjunct to pyridoxine treatment in patients with PDE-ALDH7A1 may result in an improved neurodevelopmental outcome.	Lysine	40-46	aldehyde dehydrogenase 7 family member A1	Homo sapiens	120-127
31521505-1	2019	Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27.	Lysine	136-142	chromobox 2	Mus musculus	0-8
35093670-1	2022	The polycomb repressive complex 2 (PRC2), which comprised of the core subunits: Enhancer of Zeste Homolog 2 (EZH2), Suppressor of Zeste 12 (SUZ12), and Embryonic Ectoderm Development (EED), is an essential epigenetic gene silencer responsible for depositing repressive histone H3 lysine 27 trimethylation (H3K27me3) marks on chromatin.	Lysine	280-286	embryonic ectoderm development	Homo sapiens	152-182
31340680-6	2019	Lysine restricted diet and arginine supplementation should be introduced in all the confirmed ALDH7A1 deficient patients.	Lysine	0-6	aldehyde dehydrogenase 7 family member A1	Homo sapiens	94-101
35107253-7	2022	Interestingly, NATA in the presence of proteins alpha3C and dehydrin (DHN1), which are rich in Lys residues, showed substantial deviation from mono-exponential fluorescence decay in contrast to PEST wt and Symfoil-4P pv2, which lack Lys residues.	Lysine	95-98	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	48-55
35107253-7	2022	Interestingly, NATA in the presence of proteins alpha3C and dehydrin (DHN1), which are rich in Lys residues, showed substantial deviation from mono-exponential fluorescence decay in contrast to PEST wt and Symfoil-4P pv2, which lack Lys residues.	Lysine	233-236	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	48-55
31282985-2	2019	SIRT1 can regulate gene expression by catalyzing non-histone and histone lysine residues deacetylation.	Lysine	73-79	sirtuin 1	Homo sapiens	0-5
35172677-17	2022	EZH2 inhibited miR-29b-3p expression by combining with miR-29b-3p promoter and trimethylation of histone H3-lysine 27-trimethylated upregulation, and then elevated MMP2 transcription and triggered microglia M1-type polarization, thus exacerbating depression-like behaviors and neuroinflammation of depression.	Lysine	108-114	microRNA mir-29b-3	Rattus norvegicus	15-25
35124181-10	2022	Furthermore, ZKSCAN3 was a novel substrate of SIRT1 which was deacetylated at lysine 148 residues by SIRT1.	Lysine	78-84	zinc finger with KRAB and SCAN domains 3	Mus musculus	13-20
35101451-6	2022	We identified the lysine 271 residue in the kinase domain as a major site of DLK ubiquitination and SUMO3 conjugation, and was thus responsible for regulating FKBP8-mediated proteasomal degradation that was inhibited by the substitution of the lysine 271 to arginine.	Lysine	18-24	small ubiquitin like modifier 3	Homo sapiens	100-105
31451547-8	2019	In contrast, only a single lysine methylation site was significantly changed upon PRMT1 knockdown.	Lysine	27-33	protein arginine methyltransferase 1	Homo sapiens	82-87
35101451-6	2022	We identified the lysine 271 residue in the kinase domain as a major site of DLK ubiquitination and SUMO3 conjugation, and was thus responsible for regulating FKBP8-mediated proteasomal degradation that was inhibited by the substitution of the lysine 271 to arginine.	Lysine	18-24	FKBP prolyl isomerase 8	Homo sapiens	159-164
31492675-1	2019	The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression.	Lysine	115-121	embryonic ectoderm development	Homo sapiens	73-76
35169119-1	2022	The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation of histone H3 on lysine 27 residue (H3K27me3).	Lysine	186-192	embryonic ectoderm development	Homo sapiens	89-92
35108679-3	2022	Under acute cold stress in mammals, JMJD1A, a histone H3 lysine 9 (H3K9) demethylase, upregulates thermogenic genes via beta-adrenergic signaling in BAT through higher-order chromatin structural changes that occur independent of histone demethylase activity.	Lysine	57-63	lysine demethylase 3A	Homo sapiens	36-42
31474572-6	2019	Unmodified circRNA, but not m6A-modified circRNA, directly activates RNA pattern recognition receptor RIG-I in the presence of lysine-63-linked polyubiquitin chain to cause filamentation of the adaptor protein MAVS and activation of the downstream transcription factor IRF3.	Lysine	127-133	DExD/H-box helicase 58	Homo sapiens	102-107
34320783-2	2022	Binding of hepcidin to ferroportin induces the ubiquitination of ferroportin at multiple lysine residues and subsequently causes the internalization and degradation of the ligand-channel complex within lysosomes.	Lysine	89-95	hepcidin antimicrobial peptide	Mus musculus	11-19
31107719-3	2019	MPNST frequently harbors inactivating mutations in SUZ12 or EED, resulting in PRC2 dysfunction and loss of histone H3 lysine 27 trimethylation (H3K27me3), most often seen in sporadic and radiation-associated, high-grade tumors; immunohistochemistry (IHC) for H3K27me3 is a useful diagnostic marker.	Lysine	118-124	embryonic ectoderm development	Homo sapiens	60-63
35018834-4	2022	Using site directed mutagenesis, two lysine residues were inserted into variable loop VIII of the AAV serotype 5 capsid vector (AAV5-PK2).	Lysine	37-43	prokineticin 2	Homo sapiens	133-136
35042538-9	2022	RESULTS: LSD1 specifically catalyzes the demethylation of monomethylated and demethylated histone H3 lysine at position 4 (h3k4me1, h3k4me2, h3k4me3) and lysine at position 9 (h3k9me1).	Lysine	101-107	lysine demethylase 1A	Homo sapiens	9-13
31276898-4	2019	G9a catalyzes the methylation of histone 3 lysine 9 (H3K9) and histone 3 lysine 27 (H3K27).	Lysine	43-49	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
35042538-9	2022	RESULTS: LSD1 specifically catalyzes the demethylation of monomethylated and demethylated histone H3 lysine at position 4 (h3k4me1, h3k4me2, h3k4me3) and lysine at position 9 (h3k9me1).	Lysine	154-160	lysine demethylase 1A	Homo sapiens	9-13
35053509-5	2022	By examining the available data related to the efficacy of lysine acetylation against tumor cells and elaborating the primary cancer hallmarks and the associated mechanisms to target the specific hallmarks, this review identifies the intrinsic connections between lysine acetylation and cancer hallmarks and proposes novel modalities that can be combined with HDAC inhibitors for cancer treatment with higher efficacy and minimum adverse effects.	Lysine	59-65	histone deacetylase 9	Homo sapiens	360-364
31276898-4	2019	G9a catalyzes the methylation of histone 3 lysine 9 (H3K9) and histone 3 lysine 27 (H3K27).	Lysine	73-79	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
35053509-5	2022	By examining the available data related to the efficacy of lysine acetylation against tumor cells and elaborating the primary cancer hallmarks and the associated mechanisms to target the specific hallmarks, this review identifies the intrinsic connections between lysine acetylation and cancer hallmarks and proposes novel modalities that can be combined with HDAC inhibitors for cancer treatment with higher efficacy and minimum adverse effects.	Lysine	264-270	histone deacetylase 9	Homo sapiens	360-364
31411209-1	2019	Recombinant vitronectin-grafted hydrogels were developed by adjusting surface charge of the hydrogels with grafting of poly-l-lysine for optimal culture of human embryonic stem cells (hESCs) under xeno- and feeder-free culture conditions, with elasticity regulated by crosslinking time (10-30 kPa), in contrast to conventional recombinant vitronectin coating dishes, which have a fixed stiff surface (3 GPa).	Lysine	119-132	vitronectin	Homo sapiens	12-23
31550266-0	2019	Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.	Lysine	29-35	lysine demethylase 1A	Homo sapiens	60-64
34999729-8	2022	Both IL-15 and Kdm6b-mediated demethylation of histone 3 at lysine 27 are responsible for the maturation of TCRalphabeta+CD8alphaalpha+ IELs through upregulating the expression of Gzmb and Fasl.	Lysine	60-66	interleukin 15	Mus musculus	5-10
34999729-8	2022	Both IL-15 and Kdm6b-mediated demethylation of histone 3 at lysine 27 are responsible for the maturation of TCRalphabeta+CD8alphaalpha+ IELs through upregulating the expression of Gzmb and Fasl.	Lysine	60-66	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	15-20
31534051-6	2019	We show that macrophages killed mesothelioma cells by oxeiptosis via a mechanism involving enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27-specific (H3K27-specific) methyltransferase of the polycomb repressive complex 2 (PRC2).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	91-118
34991687-9	2022	Using chromatin immunoprecipitation coupled with deep sequencing, we find that changes in histone h3, lysine 27 acetylation (H3K27ac) involve sharpening broad diffuse regions into narrow peaks centered on the promoter regions of genes driving embryonic development.	Lysine	102-108	H3 clustered histone 7	Mus musculus	90-100
34991687-11	2022	In contrast, histone h3, lysine 9 dimethylation (H3K9me2) becomes enriched within the promoters of genes driving meiosis and in the distal enhancer regions of tissue-specific genes sequestered at the nuclear lamina.	Lysine	25-31	H3 clustered histone 7	Mus musculus	13-23
31534051-6	2019	We show that macrophages killed mesothelioma cells by oxeiptosis via a mechanism involving enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27-specific (H3K27-specific) methyltransferase of the polycomb repressive complex 2 (PRC2).	Lysine	140-146	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	120-124
31527032-2	2019	This ss-lactamase possessed a three amino-acid insertion (Pro-Asn-Lys) located between amino acids 269 and 270 compared to the KPC-3 amino acid sequence.	Lysine	66-69	KPC-3	Klebsiella pneumoniae	127-132
34713507-7	2022	In P. patens mMDH1, we detected a single acetylated lysine located next to one of the four acetylation sites detected in Arabidopsis thaliana mMDH1.	Lysine	52-58	malate dehydrogenase 1, NAD (soluble)	Mus musculus	13-18
34713507-7	2022	In P. patens mMDH1, we detected a single acetylated lysine located next to one of the four acetylation sites detected in Arabidopsis thaliana mMDH1.	Lysine	52-58	malate dehydrogenase 1, NAD (soluble)	Mus musculus	142-147
34713507-11	2022	Comparative homology modeling of MDH proteins revealed that evolutionarily conserved lysines serve as hotspots of acetylation.	Lysine	85-92	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	33-36
31511540-3	2019	Here, we show that DNA damage-induced SMG7-p53 binding requires phosphorylated Ser15 on p53, and that substitution of the conserved lysine residue K66 in the SMG7 14-3-3-like domain with the glutamic acid (E) abolishes interactions with its client proteins p53 and UPF1.	Lysine	132-138	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	163-169
31295457-6	2019	The structure reveals how the PAM peptide forms key interactions simultaneously with two KR2 via the high-affinity lysine isosteres within the a1a2 motifs.	Lysine	115-121	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	30-33
31280863-4	2019	We also demonstrated that EIF3D is K27-polyubiquitinated at the lysine 153 and 275 residues in a KCTD10-dependent manner in human hepatocellular carcinoma HepG2 cells.	Lysine	64-70	eukaryotic translation initiation factor 3 subunit D	Homo sapiens	26-31
31477734-1	2019	AT-1/SLC33A1 is a key member of the endoplasmic reticulum (ER) acetylation machinery, transporting acetyl-CoA from the cytosol into the ER lumen where acetyl-CoA serves as the acetyl-group donor for Nepsilon-lysine acetylation.	Lysine	208-214	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	5-12
31256246-10	2019	In addition, we found that acetylated lysine 18 of histone H3 (H3K18ac), an established SIRT7 substrate, was increased at asynaptic chromosome regions suggesting a functional relationship between this epigenetic mark and chromosome synapsis.	Lysine	38-44	sirtuin 7	Mus musculus	88-93
31218831-7	2019	This modification occurred at lysine 758 and catalysed by Tip60.	Lysine	30-36	lysine acetyltransferase 5	Homo sapiens	58-63
31207107-3	2019	In particular, the lysine-specific demethylase KDM1A/LSD1 is linked to transcriptional regulation of target genes orchestrated by the EWS portion of the fusion protein interacting with repressive chromatin-remodeling complexes.	Lysine	19-25	lysine demethylase 1A	Homo sapiens	47-52
31207107-3	2019	In particular, the lysine-specific demethylase KDM1A/LSD1 is linked to transcriptional regulation of target genes orchestrated by the EWS portion of the fusion protein interacting with repressive chromatin-remodeling complexes.	Lysine	19-25	lysine demethylase 1A	Homo sapiens	53-57
31241165-7	2019	It acts in the same branch as FLOWERING LOCUS D, and AtGRP7 loss-of-function mutants show elevated levels of dimethylated lysine 4 of histone H3, a mark for active transcription.	Lysine	122-128	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	53-59
31194870-1	2019	The ability of histone chaperone Anti-silencing factor 1 (Asf1) to direct acetylation of lysine 56 of histone H3 (H3K56ac) represents an important regulatory step in genome replication and DNA repair.	Lysine	89-95	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	33-56
31194870-1	2019	The ability of histone chaperone Anti-silencing factor 1 (Asf1) to direct acetylation of lysine 56 of histone H3 (H3K56ac) represents an important regulatory step in genome replication and DNA repair.	Lysine	89-95	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	58-62
31439855-0	2019	The Zea mays mutants opaque2 and opaque16 disclose lysine change in waxy maize as revealed by RNA-Seq.	Lysine	51-57	regulatory protein opaque-2	Zea mays	21-28
31439855-1	2019	In maize, opaque2 (o2) and opaque16 (o16) alleles can increase lysine content, while the waxy (wx) gene can enhance the amylopectin content of grains.	Lysine	63-69	regulatory protein opaque-2	Zea mays	10-17
31435463-1	2019	BACKGROUND: Histone Lysine Specific Demethylase 1 (LSD1) is the first histone demethylase to be discovered, which regulates various biological functions by making lysine of histone H3K4, H3K9 and non-histone substrates demethylated.	Lysine	163-169	lysine demethylase 1A	Homo sapiens	51-55
31406120-4	2019	Using a calcium-imaging assay and two-voltage clamp recording, we found that one of the honey bee"s gustatory receptors, AmGr10, functions as a broadly tuned amino acid receptor responding to glutamate, aspartate, asparagine, arginine, lysine, and glutamine, but not to other sweet or bitter compounds.	Lysine	236-242	gustatory receptor 10	Apis mellifera	121-127
31253574-3	2019	The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and contain the lysine-63 linkage-specific BRCC36 subunit that is functionalized by scaffold subunits ABRAXAS and ABRO1, respectively.	Lysine	109-115	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	136-142
31186351-4	2019	Our analysis identified the E3 ubiquitin ligases ring finger protein 20 (RNF20) and RNF40, factors that in nonpancreatic cells regulate transcription through imparting monoubiquitin marks on histone H2B (H2Bub1), a precursor to histone H3 lysine 4 trimethylation (H3K4me3).	Lysine	239-245	ring finger protein 40	Mus musculus	84-89
31066329-4	2019	IPMK enhances autophagy-related transcription by stimulating AMPK-dependent SIRT1 activation, which mediates the deacetylation of histone 4 lysine 16.	Lysine	140-146	inositol polyphosphate multikinase	Homo sapiens	0-4
31066329-4	2019	IPMK enhances autophagy-related transcription by stimulating AMPK-dependent SIRT1 activation, which mediates the deacetylation of histone 4 lysine 16.	Lysine	140-146	sirtuin 1	Homo sapiens	76-81
31121497-5	2019	This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein.	Lysine	62-68	interleukin 12b	Mus musculus	144-153
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	66-74	glycine amidinotransferase	Homo sapiens	84-119
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	66-74	glycine amidinotransferase	Homo sapiens	121-125
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	76-79	glycine amidinotransferase	Homo sapiens	84-119
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Lysine	76-79	glycine amidinotransferase	Homo sapiens	121-125
31204298-1	2019	EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of embryonic stem cells.	Lysine	147-153	embryonic ectoderm development	Homo sapiens	0-3
31204298-1	2019	EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of embryonic stem cells.	Lysine	147-153	embryonic ectoderm development	Homo sapiens	5-35
31367252-8	2019	Further mechanistic investigations showed that CDYL recruits the enhancer of zeste homolog 2 (EZH2) to regulate trimethylation of lysine 27 in histone 3 (H3K27me3) at the CDKN1C promoter region and promotes transcriptional silencing.	Lysine	130-136	chromodomain Y like	Homo sapiens	47-51
31124279-1	2019	Lysine-specific demethylase 6B (KDM6B) demethylates trimethylated lysine-27 on histone H3.	Lysine	66-72	lysine demethylase 6B	Homo sapiens	0-30
31124279-1	2019	Lysine-specific demethylase 6B (KDM6B) demethylates trimethylated lysine-27 on histone H3.	Lysine	66-72	lysine demethylase 6B	Homo sapiens	32-37
31174423-0	2019	Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.	Lysine	0-6	LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A	Bos taurus	77-88
31174423-6	2019	Lys dose-dependently affects GPRC6A expression and localization at the plasma membrane.	Lysine	0-3	LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A	Bos taurus	29-35
31174423-7	2019	In summary, our data reveals that Lys enhances FAs-stimulated SREBP-1c expression and maturation leading to milk fat synthesis via the GPRC6A-PI3K-FABP5 signaling in BMECs.	Lysine	34-37	LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A	Bos taurus	135-146
31196136-9	2019	At the molecular level, we observed that SIRT7 interacts with and induces deacetylation of p53 at lysines 320 and 373.	Lysine	98-105	sirtuin 7	Homo sapiens	41-46
31205679-1	2019	Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	55-59
31205679-1	2019	Aim: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	60-65
31068376-5	2019	Exposing neurons to MAG and CSPGs decreases acetylation of Miro1 on Lysine 105 (K105) and decreases axonal mitochondrial transport.	Lysine	68-74	myelin associated glycoprotein	Homo sapiens	20-23
30954472-2	2019	Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), a core component of polycomb repressive complexes 2, possesses histone methyltransferase activity that catalyzes the trimethylation of lysine 27 of histone H3.	Lysine	201-207	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	59-63
30954472-2	2019	Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), a core component of polycomb repressive complexes 2, possesses histone methyltransferase activity that catalyzes the trimethylation of lysine 27 of histone H3.	Lysine	201-207	H3 clustered histone 7	Mus musculus	214-224
30514804-1	2019	Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3.	Lysine	124-130	lysine demethylase 1A	Homo sapiens	31-35
31018997-2	2019	Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on histone tails, has recently been reported to promote gene transcription of proinflammatory cytokines but has rarely been explored for its role in IL4-driven MTheta transcriptional programming and MTheta-mediated immunosuppression in the TME.	Lysine	77-83	delta/notch-like EGF repeat containing	Mus musculus	31-34
30971429-1	2019	Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic differentiation in vitro by catalyzing trimethylation of histone 3 lysine 27.	Lysine	225-231	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
30971429-1	2019	Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic differentiation in vitro by catalyzing trimethylation of histone 3 lysine 27.	Lysine	225-231	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
30909015-5	2019	Impressively, with the synergistic effect of N/S-cGO/L-lys/Au@Pt MBs/Thi and Au NR@PDA, the developed dual-mode electrochemical immunosensor for cTnI detection showed a wide linear concentration range (50 fg/mL to 250 ng/mL, 750 fg/mL to 100 ng/mL) and a low detection limit (16.7 fg/mL, 250 fg/mL) via i-t and DPV, respectively.	Lysine	55-58	troponin I3, cardiac type	Homo sapiens	145-149
31076406-5	2019	In addition, we found that histone H3 lysine 36 methylation (H3K36me) is a marker for JMJD1C activity at gene loci.	Lysine	38-44	jumonji domain containing 1C	Mus musculus	86-92
30801692-6	2019	Chromatin immunoprecipitation (ChIP) experiments revealed that the active chromatin mark trimethylation of lysine 4 of histone 3 (H3K4me3), was significantly enriched in areas associated with interferon-stimulated genes in STAT1 GOF cells in comparison to cells from healthy donors.	Lysine	107-113	signal transducer and activator of transcription 1	Homo sapiens	223-228
30893641-6	2019	As a proved transcription factor of FGF21, the expression of CREBH was initiated by MS-275, with increased Histone H3 Lysine 18 acetylation(H3K18ac) signals and hepatocyte nuclear factor 4 alpha (HNF-4alpha) recruitment in CREBH promoter.	Lysine	118-124	cAMP responsive element binding protein 3 like 3	Homo sapiens	61-66
30984480-13	2019	HTU-LOX deaminates usual substrates of mammalian LOX such as lysine-containing polypeptides and polymers.	Lysine	61-67	lysyl oxidase	Homo sapiens	4-7
30984480-13	2019	HTU-LOX deaminates usual substrates of mammalian LOX such as lysine-containing polypeptides and polymers.	Lysine	61-67	lysyl oxidase	Homo sapiens	49-52
30734528-0	2019	A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.	Lysine	55-61	KRAS proto-oncogene, GTPase	Homo sapiens	47-54
30734528-5	2019	Herein we report a SIRT2 inhibitor, JH-T4, which can increase K-Ras4a lysine fatty acylation.	Lysine	70-76	KRAS proto-oncogene, GTPase	Homo sapiens	62-69
30734528-6	2019	This is the first small-molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a.	Lysine	65-71	KRAS proto-oncogene, GTPase	Homo sapiens	98-105
30931944-5	2019	Mechanistically, USP8 directly removes non-classical K63-linked ubiquitin chains from EPG5 at Lysine 252, leading to enhanced interaction between EPG5 and LC3.	Lysine	94-100	ectopic P-granules 5 autophagy tethering factor	Homo sapiens	86-90
30931944-5	2019	Mechanistically, USP8 directly removes non-classical K63-linked ubiquitin chains from EPG5 at Lysine 252, leading to enhanced interaction between EPG5 and LC3.	Lysine	94-100	ectopic P-granules 5 autophagy tethering factor	Homo sapiens	146-150
30931944-5	2019	Mechanistically, USP8 directly removes non-classical K63-linked ubiquitin chains from EPG5 at Lysine 252, leading to enhanced interaction between EPG5 and LC3.	Lysine	94-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	155-158
30599084-5	2019	Additionally, we found that the depletion of iron increased the activity of lipoprotein-associated phospholipase A2 (LP-PLA2) and the production of lysophosphatidylcholine, thereby suppressing NANOG expression by enhancer of zeste homolog 2-mediated trimethylation of histone H3 lysine 27.	Lysine	279-285	phospholipase A2 group VII	Homo sapiens	76-115
30599084-5	2019	Additionally, we found that the depletion of iron increased the activity of lipoprotein-associated phospholipase A2 (LP-PLA2) and the production of lysophosphatidylcholine, thereby suppressing NANOG expression by enhancer of zeste homolog 2-mediated trimethylation of histone H3 lysine 27.	Lysine	279-285	phospholipase A2 group VII	Homo sapiens	117-124
30866496-0	2019	Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer.	Lysine	34-40	lysine demethylase 1A	Homo sapiens	62-66
30846735-0	2019	Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.	Lysine	55-61	IWS1, SUPT6 interacting protein	Mus musculus	0-4
30846735-0	2019	Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.	Lysine	55-61	SPT6, histone chaperone and transcription elongation factor	Mus musculus	9-13
30846735-1	2019	The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) and recruits the lysine methyltransferase, Setd2, to chromatin to regulate H3K36me3.	Lysine	142-148	IWS1, SUPT6 interacting protein	Mus musculus	39-43
30846735-1	2019	The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) and recruits the lysine methyltransferase, Setd2, to chromatin to regulate H3K36me3.	Lysine	142-148	SPT6, histone chaperone and transcription elongation factor	Mus musculus	89-93
30281815-11	2019	DDX5 overexpression decreased p62/TRAF6-mediated lysine 63-linked ubiquitination of mammalian target of rapamycin (mTOR) and subsequently inhibited the mTOR signaling pathway.	Lysine	49-55	sequestosome 1	Homo sapiens	30-33
30594073-4	2019	Intriguingly, P62 competes with SETD2 to bind histone H3 and then significantly reduces SETD2-binding capacity to substrate histone H3, triggering drastically the reduction of three methylation on histone H3 36th lysine (H3K36me3).	Lysine	213-219	nucleoporin 62	Homo sapiens	14-17
30804502-5	2019	We show that BRCA1 recruitment requires recognition of histone H4 unmethylated at lysine 20 (H4K20me0), linking DSB repair pathway choice directly to sister chromatid availability.	Lysine	82-88	BRCA1 DNA repair associated	Homo sapiens	13-18
30633952-0	2019	The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.	Lysine	15-18	lysine demethylase 6B	Homo sapiens	34-39
30633952-6	2019	KDM6B catalyzes the demethylation of histone H3 Lys 27 trimethylation (H3K27me3) in the promoter of SNAI1, which is important for SNAI1 upregulation.	Lysine	48-51	lysine demethylase 6B	Homo sapiens	0-5
30624906-5	2019	The binding-guide lysine reactions were first examined on an SH3 domain and then tested on several ubiquitin-like proteins such as SUMO, Atg8 protein family, plant ATG8, and mammalian LC3 proteins that contain at least seven lysine residues on the surface.	Lysine	18-24	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	184-187
30783079-5	2019	Dihydroartemisinin control of miR-34a and miR-7 expression leads to inhibition of Axl expression in a process at least partially dependent on regulation of chromatin via methylation of histone H3 lysine 27 residues by Jumonji, AT-rich interaction domain containing 2 (JARID2), and the enhancer of zeste homolog 2.	Lysine	196-202	leukocyte immunoglobulin like receptor B1	Homo sapiens	42-47
30770815-3	2019	Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abolished (ArK381R, K500R).	Lysine	77-84	androgen receptor	Mus musculus	88-90
30764507-0	2019	Molecular Mechanisms Underlying Increase in Lysine Content of Waxy Maize through the Introgression of the opaque2 Allele.	Lysine	44-50	regulatory protein opaque-2	Zea mays	106-113
30764507-1	2019	The opaque2 (o2) mutation in maize is associated with high lysine content in endosperm and good nutritional value.	Lysine	59-65	regulatory protein opaque-2	Zea mays	4-11
30764507-1	2019	The opaque2 (o2) mutation in maize is associated with high lysine content in endosperm and good nutritional value.	Lysine	59-65	regulatory protein opaque-2	Zea mays	13-15
30764507-4	2019	To reveal the mechanism of increasing lysine content through introgression of the o2 in waxy maize, the transcriptome on kernels (18th day after pollination) of the o2o2wxwx and parent lines was analyzed using RNA-sequencing (RNA-Seq).	Lysine	38-44	regulatory protein opaque-2	Zea mays	82-84
30764507-9	2019	These findings are of great importance for understanding the molecular mechanism underlying the lysine content increase due to o2 allele introgression into waxy maize.	Lysine	96-102	regulatory protein opaque-2	Zea mays	127-129
30692625-3	2019	Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its activation, which is antagonized by the Jumonji-family demethylase KDM4B.	Lysine	51-57	lysine (K)-specific demethylase 4B	Mus musculus	152-157
30700744-6	2019	In this study, we investigated the model system comprising of dimethylated histone H3 lysine 9 (H3K9me2) and its regulation by the lysine methyltransferase G9a.	Lysine	86-92	euchromatic histone lysine methyltransferase 2	Homo sapiens	156-159
30756531-1	2019	As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase.	Lysine	117-123	sirtuin 7	Homo sapiens	47-52
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	ring-box 1	Homo sapiens	141-159
30678315-3	2019	We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8).	Lysine	74-80	ring-box 1	Homo sapiens	161-165
30442713-2	2019	We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.	Lysine	64-70	SRY (sex determining region Y)-box 2	Mus musculus	30-34
30442713-2	2019	We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.	Lysine	194-197	SRY (sex determining region Y)-box 2	Mus musculus	30-34
30442713-2	2019	We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.	Lysine	205-208	SRY (sex determining region Y)-box 2	Mus musculus	30-34
30631055-4	2019	Here we report that the histone H3 lysine 27 demethylase KDM6B is an epigenetic activator of neuroblastoma cell differentiation.	Lysine	35-41	lysine demethylase 6B	Homo sapiens	57-62
30631055-7	2019	Mechanistically, KDM6B epigenetically activates the transcription of neuronal genes by removing the repressive chromatin marker histone H3 lysine 27 trimethylation.	Lysine	139-145	lysine demethylase 6B	Homo sapiens	17-22
30631055-10	2019	These findings identify a KDM6B-dependent epigenetic mechanism in the control of neuroblastoma cell differentiation, providing a rationale for reducing histone H3 lysine 27 trimethylation as a strategy for enhancing differentiation-based therapy in high-risk neuroblastoma.	Lysine	163-169	lysine demethylase 6B	Homo sapiens	26-31
30472188-4	2019	We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ.	Lysine	40-46	OTU deubiquitinase, ubiquitin aldehyde binding 2	Homo sapiens	9-14
30828079-1	2019	Lysine-specific demethylase 1 (LSD1/KDM1A) is a histone demethylase and specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 (H3K4).	Lysine	151-157	lysine demethylase 1A	Homo sapiens	31-35
30828079-1	2019	Lysine-specific demethylase 1 (LSD1/KDM1A) is a histone demethylase and specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 (H3K4).	Lysine	151-157	lysine demethylase 1A	Homo sapiens	36-41
30531907-7	2019	We propose that Q93E substitution perturbs the UBE2A catalytic microenvironment essential for lysine deprotonation during ubiquitin transfer, thus generating an enzyme that is disabled but not dead.	Lysine	94-100	ubiquitin conjugating enzyme E2 A	Homo sapiens	47-52
30111819-4	2019	In silico analysis of The Cancer Genome Atlas (TCGA) data shows that expression of histone lysine-specific demethylase 1 (LSD1) is inversely associated with the levels of cytotoxic T cell-attracting chemokines (C-C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 and 10 (CXCL9, CXCL10)) and programmed death-ligand 1 (PD-L1) in clinical TNBC specimens.	Lysine	91-97	C-X-C motif chemokine ligand 10	Homo sapiens	294-300
30154425-4	2019	Here we report that the HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and in vivo.	Lysine	111-117	lysine acetyltransferase 5	Homo sapiens	62-67
30154425-4	2019	Here we report that the HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and in vivo.	Lysine	111-117	spermatogenic leucine zipper 1	Homo sapiens	130-134
30154425-4	2019	Here we report that the HIV-1 Tat-interacting protein 60 kDa (Tip60) acetyltransferase mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration in vitro and in vivo.	Lysine	111-117	spermatogenic leucine zipper 1	Homo sapiens	222-226
30099980-2	2019	In the mouse zygote, dimethylated histone H3 lysine 9 (H3K9me2) attracts Dppa3 to prevent Tet3-mediated oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC).	Lysine	45-51	developmental pluripotency-associated 3	Mus musculus	73-78
30532138-4	2018	Here, by using Kaposi"s sarcoma-associated herpesvirus (KSHV) as a model, we revealed that RTA, the master regulator of lytic replication, interacts with STAT6 and promotes lysine 48 (K48) and K63-linked ubiquitylation of STAT6 for degradation via the proteasome and lysosome systems.	Lysine	173-179	ORF50	Human gammaherpesvirus 8	91-94
30191331-7	2018	GlnS expression was significantly lowered in skeletal muscle by &gt;= 1.5% supplemental Lys compared to the Control (P &lt; 0.05).	Lysine	88-91	glutamate-ammonia ligase	Rattus norvegicus	0-4
30191331-11	2018	These results showed that dietary supplementation with &gt;= 1.5% Lys significantly suppressed GlnS expression in the skeletal muscle, which may contribute to the decreased serum Gln levels, and that increased serum PP by Lys may be due to suppressed catabolism rather than increased synthesis of PP.	Lysine	66-69	glutamate-ammonia ligase	Rattus norvegicus	95-99
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Lysine	123-126	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Lysine	123-126	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73
30534415-3	2019	We also demonstrated that the important stem cell marker Lgr5 was epigenetically silenced by trimethylation of histone H3 lysine 27, inducing suppression of Wnt signaling and a decrease of cell proliferation in organoids from aged mice.	Lysine	122-128	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	57-61
30504241-8	2018	This incomplete block of KCNQ2/3 channels by HN38 appears to be partially due to the conformation of the KCNQ2/3 outer vestibule and in particular the outer turret lysine 259 of KCNQ3 channels.	Lysine	164-170	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	25-30
30305391-3	2018	The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2, represses target genes through trimethylation of histone H3 at Lys-27 (H3K27me3), and interacts (in)directly with both protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 (NIPP1).	Lysine	187-190	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	59-63
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	97-103	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	23-29
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	97-103	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	49-54
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	114-117	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	23-29
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	114-117	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	49-54
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	123-126	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	23-29
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	123-126	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	49-54
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	123-126	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	23-29
30323061-8	2018	Finally, we found that GCN5L1-knockout mice lack HADHA that is hyperacetylated at three specific lysine residues (Lys-350, Lys-383, and Lys-406) and that acetylation at these sites is significantly associated with increased HADHA activity.	Lysine	123-126	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Mus musculus	49-54
30446507-3	2018	This process is governed by the ER acetylation machinery: the cytosol:ER-lumen acetyl-CoA transporter AT-1 (also known as SLC33A1), and the ER-resident lysine acetyltransferases ATase1 and ATase2 (also known as NAT8B and NAT8, respectively).	Lysine	152-158	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	122-129
30389664-7	2018	HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis.	Lysine	60-66	cAMP responsive element binding protein 3-like 3	Mus musculus	51-56
30389664-7	2018	HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis.	Lysine	60-66	cAMP responsive element binding protein 3-like 3	Mus musculus	223-228
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	155-160
30488017-1	2018	The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal biology, and diseases such as MLL-rearranged leukemia.	Lysine	15-21	dpy-30 histone methyltransferase complex regulatory subunit	Homo sapiens	166-171
30278358-5	2018	Post-translationally modified YB-1 (lysine 301/304 acetylation) is detected at high levels in the nucleus of adherent and invading CD14+CD68+ monocytes from umbilical cord and atherosclerosis-prone vessels.	Lysine	36-42	CD68 molecule	Homo sapiens	136-140
30405805-7	2018	The JMJD1A protein, but not a catalytically inactive mutant, activated the ATRX gene promoter and JMJD1A also affected levels of dimethylation on lysine 9 of histone H3.	Lysine	146-152	lysine demethylase 3A	Homo sapiens	4-10
30405805-7	2018	The JMJD1A protein, but not a catalytically inactive mutant, activated the ATRX gene promoter and JMJD1A also affected levels of dimethylation on lysine 9 of histone H3.	Lysine	146-152	lysine demethylase 3A	Homo sapiens	98-104
30359362-4	2018	CTCF-dependent looping is dependent on the expression of the CTCF-associated Yin Yang 1 (YY1) transcription factor and polycomb repressor complex (PRC) recruitment, resulting in trimethylation of histone H3 at lysine 27.	Lysine	210-216	CCCTC-binding factor	Homo sapiens	0-4
30359362-4	2018	CTCF-dependent looping is dependent on the expression of the CTCF-associated Yin Yang 1 (YY1) transcription factor and polycomb repressor complex (PRC) recruitment, resulting in trimethylation of histone H3 at lysine 27.	Lysine	210-216	CCCTC-binding factor	Homo sapiens	61-65
29688807-3	2018	We find that p300-driven acetylation of Siah2 at lysine 139 residue stabilizes the molecule in infected cells, thereby substantially increasing its efficiency to degrade prolyl hydroxylase (PHD)3 in the gastric epithelium.	Lysine	49-55	siah E3 ubiquitin protein ligase 2	Mus musculus	40-45
30323286-3	2018	Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly conserved and intrinsically disordered autoinhibitory lysine-rich loop, resulting in p300 activation.	Lysine	217-223	signal transducer and activator of transcription 1	Homo sapiens	48-53
30257200-7	2018	In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents tissue regeneration.	Lysine	64-70	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	174-178
29966650-9	2018	Lastly, we determined that GST-tagged full-length p62 binds to Lys-63-linked polyubiquitin chains but not to Lys-48-linked chains.	Lysine	63-66	sequestosome 1	Homo sapiens	50-53
29969683-5	2018	In the presence of BR, the transcription factor BRASSINAZOLE-RESISTANT1 (BZR1), together with BES1-INTERACTING MYC-like proteins (BIMs), specifically binds a BR- responsive element in the first intron of FLC and further recruits a histone 3 lysine 27 (H3K27) demethylase to downregulate levels of the repressive H3K27 trimethylation mark and thus antagonize Polycomb silencing at FLC, leading to its activation.	Lysine	241-247	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	48-71
29969683-5	2018	In the presence of BR, the transcription factor BRASSINAZOLE-RESISTANT1 (BZR1), together with BES1-INTERACTING MYC-like proteins (BIMs), specifically binds a BR- responsive element in the first intron of FLC and further recruits a histone 3 lysine 27 (H3K27) demethylase to downregulate levels of the repressive H3K27 trimethylation mark and thus antagonize Polycomb silencing at FLC, leading to its activation.	Lysine	241-247	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	73-77
30060157-5	2018	Our results show that GDF9 + BMP15 through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of histone 3 lysine 27 (H3K27ac), facilitating AMH/Amh expression.	Lysine	188-194	growth differentiation factor 9	Homo sapiens	22-26
29997151-3	2018	As KDM1A/lysine-specific demethylase 1 (LSD1) is highly expressed in Ewing sarcoma cell lines and tumors, with elevated expression levels associated with worse overall survival (P = 0.033), this study has examined biomarkers of sensitivity and mechanisms of cytotoxicity to targeted KDM1A inhibition using SP-2509 (reversible KDM1A inhibitor).	Lysine	9-15	lysine demethylase 1A	Homo sapiens	40-44
29959229-5	2018	We show that Rpl29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1 (also known as Kdm1a).	Lysine	19-25	ribosomal protein L29	Homo sapiens	13-18
29959229-5	2018	We show that Rpl29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1 (also known as Kdm1a).	Lysine	19-25	lysine demethylase 1A	Homo sapiens	101-105
29959229-5	2018	We show that Rpl29 lysine 5 (Rpl29K5) is methylated exclusively by Set7/9 and can be demethylated by Lsd1 (also known as Kdm1a).	Lysine	19-25	lysine demethylase 1A	Homo sapiens	121-126
30057114-2	2018	Although overexpression and stabilization of the histone H3 lysine 9/36 (H3K9/36) tri-demethylase KDM4A generates transient site-specific copy number gains (TSSGs), additional mechanisms directly controlling site-specific DNA copy gains are not well defined.	Lysine	60-66	lysine demethylase 4A	Homo sapiens	98-103
30082873-1	2018	Lysyl oxidase (LOX) catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagens and elastin, which is the first step of the cross-linking of these extracellular matrix proteins.	Lysine	59-65	elastin	Homo sapiens	110-117
29177481-5	2018	While the C-terminal region, containing the enoyl-CoA hydratase like (ECH) domain, of CDYL1 binds to poly (ADP-ribose) (PAR) moieties and mediates CDYL1 accumulation at DNA damage sites, the chromodomain and histone H3 trimethylated on lysine 9 (H3K9me3) mark are dispensable for its recruitment.	Lysine	236-242	chromodomain Y like	Homo sapiens	86-91
30114340-9	2018	Mutation of the fifth residue, aspartate, to alanine or lysine has a dramatic impact on binding affinity for CCR6 and ligand potency.	Lysine	56-62	C-C motif chemokine receptor 6	Homo sapiens	109-113
29744651-5	2018	Dihydrodipicolinate synthase (DHDPS; EC 4.3.3.7) catalyzes the first committed step in the lysine biosynthesis pathway of plants.	Lysine	91-97	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	0-28
29744651-5	2018	Dihydrodipicolinate synthase (DHDPS; EC 4.3.3.7) catalyzes the first committed step in the lysine biosynthesis pathway of plants.	Lysine	91-97	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	30-35
29744651-8	2018	Enzyme kinetic studies demonstrate that the recombinant Ta-DHDPS has a KM (pyruvate) of 0.45 mM, KM (l-aspartate-4-semialdehyde) of 0.07 mM, kcat of 56 s-1, and is inhibited by lysine (IC 50 LYS of 0.033 mM), which agree well with previous studies using labor-intensive purification from wheat suspension cultures.	Lysine	177-183	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	59-64
29744651-8	2018	Enzyme kinetic studies demonstrate that the recombinant Ta-DHDPS has a KM (pyruvate) of 0.45 mM, KM (l-aspartate-4-semialdehyde) of 0.07 mM, kcat of 56 s-1, and is inhibited by lysine (IC 50 LYS of 0.033 mM), which agree well with previous studies using labor-intensive purification from wheat suspension cultures.	Lysine	191-194	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	59-64
29970899-6	2018	In a mechanistic manner, we also showed that SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 (EZH2, which is regarded as the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), specifying the histone alteration pattern on the target genes, including CDKN1A, and, as a result, altered the CCA cell biology.	Lysine	321-327	small nucleolar RNA host gene 1	Homo sapiens	45-50
29143703-13	2018	Increasing SID Trp : Lys increased (P&lt;0.05) feed efficiency (G : F) quadratically in Exp 1, 3 and 4.	Lysine	21-24	alpha expansin 1	Zea mays	88-102
29481307-7	2018	Interestingly, induction of proliferating cell nuclear antigen (PCNA), a major player of the cell-cycle regulation, was correlated with trimethylated lysine 27 in histone H3 loss around the gene promoters.	Lysine	150-156	proliferating cell nuclear antigen	Mus musculus	28-62
29481307-7	2018	Interestingly, induction of proliferating cell nuclear antigen (PCNA), a major player of the cell-cycle regulation, was correlated with trimethylated lysine 27 in histone H3 loss around the gene promoters.	Lysine	150-156	proliferating cell nuclear antigen	Mus musculus	64-68
29735733-3	2018	In apo-GroEL, the nucleotide-binding sites of different rings are connected to one another by the interaction of the e-amino group of lysine 105 of one helix D across the twofold axis with the negatively charged carbonyl oxygen atom of alanine 109 at the C-terminus of the other helix D. Upon binding ATP, the K105-A109 salt bridge breaks and both helices move apart by approximately 3.5 A en bloc toward the ATP.	Lysine	134-140	heat shock protein family D (Hsp60) member 1	Homo sapiens	7-12
29921310-2	2018	KDM1A, containing a flavin adenine dinucleotide (FAD)-dependent amine oxidase domain, demethylates histone 3 lysine 4 and histone 3 lysine 9 (H3K4me1/2 and H3K9me1/2).	Lysine	109-115	lysine demethylase 1A	Homo sapiens	0-5
29921310-2	2018	KDM1A, containing a flavin adenine dinucleotide (FAD)-dependent amine oxidase domain, demethylates histone 3 lysine 4 and histone 3 lysine 9 (H3K4me1/2 and H3K9me1/2).	Lysine	132-138	lysine demethylase 1A	Homo sapiens	0-5
29604308-6	2018	Finally, we found that the Lys-372 residue of TRIM50, critical for its own acetylation, is necessary for its E3 ligase activity that governs Beclin1 ubiquitination.	Lysine	27-30	beclin 1	Homo sapiens	141-148
29512695-7	2018	In addition, Aurora B undergoes modification by SUMO2, but not by SUMO1, in vivo and in vitro, and Lys-207 is a major modification site.	Lysine	99-102	aurora kinase C	Mus musculus	13-21
29594337-3	2018	Here, we investigated whether targeting KDM6B, the demethylase of tri-methylated histone H3 lysine 27 (H3K27me3), has a therapeutic potential for AML.	Lysine	92-98	lysine demethylase 6B	Homo sapiens	40-45
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Lysine	77-83	nth like DNA glycosylase 1	Homo sapiens	55-59
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Lysine	222-228	nth like DNA glycosylase 1	Homo sapiens	55-59
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Lysine	222-228	nth like DNA glycosylase 1	Homo sapiens	216-220
29754817-4	2018	Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively.	Lysine	41-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	51-54
29754817-4	2018	Alternative recognition of an acetylated lysine in VDR by bromodomain proteins BRD7 and BRD9 directs association to PBAF and BAF chromatin remodeling complexes, respectively.	Lysine	41-47	bromodomain containing 9	Mus musculus	88-92
29559475-2	2018	Here, we identified familial and early-onset multiple myeloma kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates hematopoietic stem cell self-renewal.	Lysine	100-106	lysine demethylase 1A	Homo sapiens	131-135
29559475-2	2018	Here, we identified familial and early-onset multiple myeloma kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates hematopoietic stem cell self-renewal.	Lysine	100-106	lysine demethylase 1A	Homo sapiens	136-141
29559475-2	2018	Here, we identified familial and early-onset multiple myeloma kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates hematopoietic stem cell self-renewal.	Lysine	226-232	lysine demethylase 1A	Homo sapiens	131-135
29559475-2	2018	Here, we identified familial and early-onset multiple myeloma kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates hematopoietic stem cell self-renewal.	Lysine	226-232	lysine demethylase 1A	Homo sapiens	136-141
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	93-99	tripartite motif containing 24	Homo sapiens	11-17
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	93-99	tripartite motif containing 24	Homo sapiens	165-171
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	117-123	tripartite motif containing 24	Homo sapiens	11-17
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	117-123	tripartite motif containing 24	Homo sapiens	165-171
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	117-123	tripartite motif containing 24	Homo sapiens	11-17
29523690-5	2018	Binding of TRIM24 to chromatin via its tandem PHD-bromodomain, which recognizes unmethylated lysine 4 and acetylated lysine 23 of histone H3 (H3K4me0/K23ac), led to TRIM24 SUMOylation at lysine residues 723 and 741.	Lysine	117-123	tripartite motif containing 24	Homo sapiens	165-171
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2A	Homo sapiens	83-87
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2A	Homo sapiens	272-276
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2A	Homo sapiens	83-87
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2A	Homo sapiens	272-276
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	238-241	lysine acetyltransferase 2A	Homo sapiens	83-87
29555684-9	2018	However, interestingly, viral polymerase activities were increased by the PCAF silencing and were decreased by the GCN5 silencing, suggesting that acetylation of the Lys-31 and Lys-90 residues has opposing effects on viral replication.	Lysine	166-169	lysine acetyltransferase 2A	Homo sapiens	115-119
28945358-0	2018	Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.	Lysine	0-7	TATA-box binding protein associated factor 15	Homo sapiens	65-70
28945358-6	2018	Mutation of CTD lysines in heptad position 7 to consensus serines reduced the overall level of TAF15 fibril binding, suggesting that electrostatic interactions contribute to complex formation.	Lysine	16-23	TATA-box binding protein associated factor 15	Homo sapiens	95-100
29439916-1	2018	LSD1/KDM1 is a histone demethylase that preferentially removes methyl groups from the mono- and di-methylated lysine 4 in histone H3 (H3K4), key marks for active chromatin for transcriptional activation.	Lysine	110-116	lysine demethylase 1A	Homo sapiens	0-4
29439916-1	2018	LSD1/KDM1 is a histone demethylase that preferentially removes methyl groups from the mono- and di-methylated lysine 4 in histone H3 (H3K4), key marks for active chromatin for transcriptional activation.	Lysine	110-116	lysine demethylase 1A	Homo sapiens	5-9
29629903-7	2018	ZMYND8 acetylation at lysines 1007 and 1034 by p300 is required for HIF activation and breast cancer progression and metastasis.	Lysine	22-29	zinc finger MYND-type containing 8	Homo sapiens	0-6
29248547-3	2018	Here we report that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 lysine 27 trimethylation, is overexpressed in CD30+ anaplastic cells in primary cutaneous anaplastic T-cell lymphoma and large-cell transformed cutaneous T-cell lymphoma.	Lysine	136-142	TNF receptor superfamily member 8	Homo sapiens	182-186
29511085-10	2018	Amino acid sequence alignments of SALL family members indicated that the region around SALL4 Lys-190 is conserved in both SALL1 and SALL3.	Lysine	93-96	spalt like transcription factor 4	Homo sapiens	87-92
29511085-10	2018	Amino acid sequence alignments of SALL family members indicated that the region around SALL4 Lys-190 is conserved in both SALL1 and SALL3.	Lysine	93-96	spalt like transcription factor 1	Homo sapiens	122-127
29765472-4	2018	Therefore, we developed novel cyclic NGR peptide-daunomycin conjugates in which Lys was replaced by different amino acids (Ala, Leu, Nle, Pro, Ser).	Lysine	80-83	reticulon 4 receptor	Homo sapiens	37-40
29578333-4	2018	Cross-linking and size-exclusion chromatography showed that the mutations resulted in reduced self-association, generating a predominantly monomeric apoA-I when five or six lysine residues were substituted.	Lysine	173-179	apolipoprotein A-I	Mus musculus	149-155
29578333-5	2018	The rate of phosphatidylcholine vesicle solubilization was enhanced for all variants, with approximately a threefold rate enhancement for apoA-I lacking Lys 206, 208, 238, and 239, or Glu 234 and 235.	Lysine	153-156	apolipoprotein A-I	Mus musculus	138-144
29578333-7	2018	ApoA-I mediated cellular lipid efflux from wild-type mice macrophage foam cells was decreased for the variant with five lysine mutations.	Lysine	120-126	apolipoprotein A-I	Mus musculus	0-6
29774081-10	2018	G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth.	Lysine	24-30	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
29465625-4	2018	Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal domain protein (BET) family and functions as a chromatin "reader" that binds acetylated lysines in histones in brain neurons to mediate the transcriptional regulation underlying learning and memory.	Lysine	177-184	bromodomain containing 4	Rattus norvegicus	0-32
29465625-4	2018	Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal domain protein (BET) family and functions as a chromatin "reader" that binds acetylated lysines in histones in brain neurons to mediate the transcriptional regulation underlying learning and memory.	Lysine	177-184	bromodomain containing 4	Rattus norvegicus	34-38
29642005-5	2018	We find that MIB2 represses the cytotoxic potential of RIPK1 by ubiquitylating lysine residues in the C-terminal portion of RIPK1.	Lysine	79-85	MIB E3 ubiquitin protein ligase 2	Homo sapiens	13-17
29642005-7	2018	Disruption of MIB2-mediated ubiquitylation, either by mutation of MIB2"s E3 activity or RIPK1"s ubiquitin-acceptor lysines, sensitizes cells to RIPK1-mediated cell death.	Lysine	115-122	MIB E3 ubiquitin protein ligase 2	Homo sapiens	14-18
29581294-2	2018	The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for ECM modeling.	Lysine	29-35	elastin	Homo sapiens	94-101
29330620-2	2018	We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive either resveratrol (40 mg or 500 mg) or a placebo for 6 months.	Lysine	107-113	sirtuin 1	Homo sapiens	49-55
29593216-5	2018	Klf4 polyglutamylation at Glu381 by tubulin tyrosine ligase-like 4 (TTLL4) and TTLL1 during cell reprogramming impedes its lysine 48-linked ubiquitination and sustains Klf4 stability.	Lysine	123-129	tubulin tyrosine ligase-like family, member 4	Mus musculus	36-66
29593216-5	2018	Klf4 polyglutamylation at Glu381 by tubulin tyrosine ligase-like 4 (TTLL4) and TTLL1 during cell reprogramming impedes its lysine 48-linked ubiquitination and sustains Klf4 stability.	Lysine	123-129	tubulin tyrosine ligase-like family, member 4	Mus musculus	68-73
29632530-3	2018	Here, we showed that Ezh2, an enzymatic component of polycomb repressive complex 2 (PRC2) catalyzing the trimethylation of lysine 27 on histone 3 (H3K27me3), regulates activation induced naive CD8+ T cells proliferation and apoptosis.	Lysine	123-129	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	21-25
29581438-3	2018	Lysine-specific crosslinking mass spectrometry provided distance constraints to select a homology model of the DNAJB6 monomer, which was subsequently used in crosslink-assisted docking to generate a dimer model.	Lysine	0-6	DnaJ heat shock protein family (Hsp40) member B6	Homo sapiens	111-117
29662616-1	2018	Lysine demethylase 2A (KDM2A) functions in transcription as a demethylase of lysine 36 on histone H3.	Lysine	77-83	lysine demethylase 2A	Homo sapiens	0-21
29662616-1	2018	Lysine demethylase 2A (KDM2A) functions in transcription as a demethylase of lysine 36 on histone H3.	Lysine	77-83	lysine demethylase 2A	Homo sapiens	23-28
29721150-6	2018	Sirt3 modulates age-associated mitochondrial biology and function via lysine deacetylation of target proteins, and we show that its regulation depends on its nitration status and is benefited by the improved NAD+/NADH ratio in aged p66Shc(-/-) brain mitochondria.	Lysine	70-76	src homology 2 domain-containing transforming protein C1	Mus musculus	232-238
29358331-2	2018	SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis.	Lysine	26-32	SRY (sex determining region Y)-box 2	Mus musculus	0-4
29358331-2	2018	SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis.	Lysine	38-41	SRY (sex determining region Y)-box 2	Mus musculus	0-4
29358331-2	2018	SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis.	Lysine	38-41	SRY (sex determining region Y)-box 2	Mus musculus	158-162
29358331-6	2018	Our studies further revealed that PHF20L1 binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis.	Lysine	68-71	SRY-box transcription factor 2	Homo sapiens	90-94
29358331-6	2018	Our studies further revealed that PHF20L1 binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis.	Lysine	79-82	SRY-box transcription factor 2	Homo sapiens	90-94
29323787-5	2018	Here, we showed that UVSSA is mono-ubiquitinated in vitro and identified a lysine residue (Lys414 ) in UVSSA as the target of ubiquitination.	Lysine	75-81	UV stimulated scaffold protein A	Homo sapiens	21-26
29323787-5	2018	Here, we showed that UVSSA is mono-ubiquitinated in vitro and identified a lysine residue (Lys414 ) in UVSSA as the target of ubiquitination.	Lysine	75-81	UV stimulated scaffold protein A	Homo sapiens	103-108
28777446-6	2018	We examined the effects of lysine-212 (K212) acetylation and found that acetylation of this site accelerates autophagy-mediated EB1 degradation.	Lysine	27-33	microtubule associated protein RP/EB family member 1	Homo sapiens	128-131
29666347-3	2018	In this study, recessive opaque2 (o2) allele that confers enhanced endosperm lysine and tryptophan, was introgressed using marker-assisted backcross breeding into three normal inbred lines (HKI323, HKI1105 and HKI1128).	Lysine	77-83	regulatory protein opaque-2	Zea mays	25-32
29254825-1	2018	The histone H3 lysine 27 (H3K27) demethylase Kdm6b (Jmjd3) can promote cellular differentiation, however its physiological functions in neurons remain to be fully determined.	Lysine	15-21	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	45-50
29254825-1	2018	The histone H3 lysine 27 (H3K27) demethylase Kdm6b (Jmjd3) can promote cellular differentiation, however its physiological functions in neurons remain to be fully determined.	Lysine	15-21	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	52-57
29286108-0	2018	miR-197-3p-induced downregulation of lysine 63 deubiquitinase promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.	Lysine	37-43	microRNA 197	Homo sapiens	0-7
29286108-5	2018	Via in silico modeling, western blot analyses and dual-luciferase assays, it was confirmed that miR-197-3p directly targets the lysine 63 deubiquitinase (CYLD) gene.	Lysine	128-134	microRNA 197	Homo sapiens	96-103
29286108-5	2018	Via in silico modeling, western blot analyses and dual-luciferase assays, it was confirmed that miR-197-3p directly targets the lysine 63 deubiquitinase (CYLD) gene.	Lysine	128-134	CYLD lysine 63 deubiquitinase	Homo sapiens	154-158
29330289-7	2018	BRCA1 mediates Oct1 ubiquitylation and degradation, and mutation of two ubiquitylated Oct1 lysines insulates the protein against BRCA1-mediated destabilization.	Lysine	91-98	BRCA1 DNA repair associated	Homo sapiens	129-134
29250818-7	2018	ATX4 and ATX5 directly bind to the AHG3 locus and trimethylate histone H3 of Lys 4 (H3K4).	Lysine	77-80	SET domain protein 16	Arabidopsis thaliana	0-4
29482987-2	2018	Loss-of-function mutations in EED or SUZ12, which encode the core subunit of polycomb repressive complex 2 (PRC2), were reported in MPNSTs, and the mutations were shown to cause inactivation of PRC2, leading to loss of trimethylation of histone H3 at lysine 27 (H3K27me3).	Lysine	251-257	embryonic ectoderm development	Homo sapiens	30-33
29345925-3	2018	In this study, the X-ray structure of a trapped E3-E2~NEDD8-target intermediate (RBX1-UBC1~NEDD8-CUL1-DCN1) is used to build computer models, and combined quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) and free energy (potential of mean force) simulations are performed to investigate the catalytic mechanism of the NEDD8 transfer from E2 to the lysine residue (K720) on the substrate in the complex.	Lysine	369-375	ring-box 1	Homo sapiens	81-85
29471853-13	2018	Mechanistically, HBXIP prevented chaperone-mediated autophagy (CMA)-dependent degradation of HOXB13 via enhancement of HOXB13 acetylation at the lysine 277 residue, causing the accumulation of HOXB13.	Lysine	145-151	homeobox B13	Homo sapiens	119-125
29471853-13	2018	Mechanistically, HBXIP prevented chaperone-mediated autophagy (CMA)-dependent degradation of HOXB13 via enhancement of HOXB13 acetylation at the lysine 277 residue, causing the accumulation of HOXB13.	Lysine	145-151	homeobox B13	Homo sapiens	119-125
29294313-4	2018	By using bioinformatics, mass spectrometry analysis, and co-immunoprecipitation assays, here we show that DENV-NS1 is ubiquitinated on multiples lysine residues during DENV infection, including K189, a lysine residue previously shown to be important for efficient DENV replication.	Lysine	145-151	influenza virus NS1A binding protein	Homo sapiens	111-114
29294313-4	2018	By using bioinformatics, mass spectrometry analysis, and co-immunoprecipitation assays, here we show that DENV-NS1 is ubiquitinated on multiples lysine residues during DENV infection, including K189, a lysine residue previously shown to be important for efficient DENV replication.	Lysine	202-208	influenza virus NS1A binding protein	Homo sapiens	111-114
29416009-6	2018	Further analysis revealed that GCN5 promoted osteogenic differentiation of BMSCs by increasing acetylation on histone 3 lysine 9 loci on the promoters of Wnt genes.	Lysine	120-126	K(lysine) acetyltransferase 2A	Mus musculus	31-35
29402921-5	2018	The mRNA abundances of IL-4 in the kidney (P &lt; 0.05) and IL-10 in the liver (P &lt; 0.05) were significantly lower in the lysine-restricted group compared with the control group.	Lysine	125-131	interleukin 10	Homo sapiens	60-65
29052959-8	2018	The lysine residue was also converted into an azide group in both a linear and reversed cyclic peptide sequences cyclo(K(N3)larllt) (Cyclo.L1.1) to allow for subsequent "click" conjugation.	Lysine	4-10	immunoglobulin kappa variable 1-6	Homo sapiens	139-143
29113759-2	2018	The euchromatic G9a histone methyltransferase (G9a HMT) is a key enzyme catalyzing histone H3 methylation on lysines 9 and 27, and its dysregulation has been linked to uncontrolled proliferation of tumor cells.	Lysine	109-116	euchromatic histone lysine methyltransferase 2	Homo sapiens	16-45
29113759-2	2018	The euchromatic G9a histone methyltransferase (G9a HMT) is a key enzyme catalyzing histone H3 methylation on lysines 9 and 27, and its dysregulation has been linked to uncontrolled proliferation of tumor cells.	Lysine	109-116	euchromatic histone lysine methyltransferase 2	Homo sapiens	47-54
29378702-3	2018	To elucidate the mechanism of Dnd1 mutation-induced teratoma formation, we focused on histone H3 lysine 27 (H3K27) trimethylation (me3), and found that the levels of H3K27me3 and its responsible methyltransferase, enhancer of zeste homolog 2 (Ezh2), were decreased in the teratoma-forming cells of Dnd1 mutant embryos.	Lysine	97-103	DND microRNA-mediated repression inhibitor 1	Mus musculus	30-34
29228324-7	2018	Moreover, we found that eIF4A1, which is primarily ubiquitinated at Lys-369, is the substrate of USP9X.	Lysine	68-71	ubiquitin specific peptidase 9 X-linked	Homo sapiens	97-102
29180469-3	2018	SIRT5 interaction directly mediated desuccinylation of lysine 280 on SHMT2, which was crucial for activating its enzymatic activity.	Lysine	55-61	serine hydroxymethyltransferase 2	Homo sapiens	69-74
29180469-4	2018	Conversely, hypersuccinylation of SHMT2 at lysine 280 was sufficient to inhibit its enzymatic activity and downregulate tumor cell growth in vitro and in vivo Notably, SIRT5 inactivation led to SHMT2 enzymatic downregulation and to abrogated cell growth under metabolic stress.	Lysine	43-49	serine hydroxymethyltransferase 2	Homo sapiens	34-39
29376035-4	2017	TRP32 is both mono- and polyubiquitinated on multiple lysine residues during infection and when ectopically expressed.	Lysine	54-60	thioredoxin like 1	Homo sapiens	0-5
29376035-10	2017	These alterations in localization corresponded to changes in TRP32 transcriptional repressor function with heclin-treated and single lysine mutants unable to repress transcription of a TRP32 target genes in a luciferase assay.	Lysine	133-139	thioredoxin like 1	Homo sapiens	61-66
28947618-4	2018	Precursor processing after the first di-glycine motif by the ubiquitin-specific proteases Ubp5 and Ubp15 generates a short-lived activated Sde2-C fragment with an N-terminal lysine residue, which subsequently gets incorporated into spliceosomes.	Lysine	174-180	SDE2 telomere maintenance homolog	Homo sapiens	139-143
29070530-3	2018	Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in a therapeutically targetable manner.	Lysine	32-38	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	69-104
29070530-3	2018	Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in a therapeutically targetable manner.	Lysine	32-38	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	106-111
30033772-0	2018	Poly-l-lysine-coated superparamagnetic nanoparticles: a novel method for the transfection of pro-BDNF into neural stem cells.	Lysine	0-13	brain derived neurotrophic factor	Homo sapiens	97-101
30033772-1	2018	Poly-l-lysine-coated superparamagnetic iron oxide nanoparticles (SPIONs-PLL) were prepared and used as a novel-carrier for the transfer of brain-derived neurotrophic factor (BDNF) into neural stem cells (NSCs) under the beneficial influence of an external magnetic field.	Lysine	0-13	brain derived neurotrophic factor	Homo sapiens	139-172
30033772-1	2018	Poly-l-lysine-coated superparamagnetic iron oxide nanoparticles (SPIONs-PLL) were prepared and used as a novel-carrier for the transfer of brain-derived neurotrophic factor (BDNF) into neural stem cells (NSCs) under the beneficial influence of an external magnetic field.	Lysine	0-13	brain derived neurotrophic factor	Homo sapiens	174-178
29954236-4	2018	Cells deficient in ASF1A/B or CAF-1 exhibit reduced histone H4 lysine 16 acetylation (H4K16ac), a histone mark known to promote ATM activation.	Lysine	63-69	anti-silencing function 1A histone chaperone	Homo sapiens	19-26
28923496-9	2018	RESULTS: The KO mice had metabolic features of MNADK-deficient patients, such as increased serum concentrations of lysine and C10:2 carnitine.	Lysine	115-121	NAD kinase 2, mitochondrial	Mus musculus	47-52
29437725-4	2018	Recently, we identified the YEATS domain of AF9 (ALL1 fused gene from chromosome 9) as a novel acetyl-lysine-binding module and showed that the ENL (eleven-nineteen leukemia) YEATS domain is an essential acetyl-histone reader in acute myeloid leukemias.	Lysine	102-108	ALL1	Homo sapiens	49-53
29105190-0	2018	An acetylatable lysine controls CRP function in E. coli.	Lysine	16-22	catabolite gene activator protein	Escherichia coli	32-35
29105190-4	2018	Here, we demonstrate that a lysine (K100) on the surface of CRP has a dual function: to promote CRP activity at Class II promoters, and to ensure proper CRP steady state levels.	Lysine	28-34	catabolite gene activator protein	Escherichia coli	60-63
29105190-4	2018	Here, we demonstrate that a lysine (K100) on the surface of CRP has a dual function: to promote CRP activity at Class II promoters, and to ensure proper CRP steady state levels.	Lysine	28-34	catabolite gene activator protein	Escherichia coli	96-99
29105190-4	2018	Here, we demonstrate that a lysine (K100) on the surface of CRP has a dual function: to promote CRP activity at Class II promoters, and to ensure proper CRP steady state levels.	Lysine	28-34	catabolite gene activator protein	Escherichia coli	96-99
29302400-2	2017	JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and embryonic stem cell (ESC) differentiation by modifying histone lysines.	Lysine	217-224	jumonji, AT rich interactive domain 2	Mus musculus	0-6
29016222-4	2017	The amyloidogenic variant, V122I TTR, was incorrectly identified in 26/27 wild-type and non-V122I variant samples due to its close mass spectral similarity with the methyl lysine-modified WT peptide [126KMe]105-127 (p.[146 KMe]125-147) generated during formalin fixation.	Lysine	172-178	transthyretin	Homo sapiens	33-36
28527011-2	2017	This role involves its DNA-binding domain, which is composed of a tandem array of zinc fingers, and PRDM9-dependent trimethylation of histone H3 at lysine 4.	Lysine	148-154	PR domain containing 9	Mus musculus	100-105
28229434-2	2017	Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.	Lysine	180-186	histamine N-methyltransferase	Homo sapiens	70-73
29261844-3	2017	Enhancer of Zeste homolog 2 (Ezh2), which catalyzes dimethylation/trimethylation of histone 3 lysine 27 (H3K27me2 and me3), is also associated with DNA methylation.	Lysine	94-100	malic enzyme 3	Homo sapiens	118-121
28487543-1	2017	Recent studies have delineated cancer-type-specific roles of histone 3 lysine 27 (H3K27) demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity.	Lysine	71-77	lysine demethylase 6B	Homo sapiens	101-106
28487543-1	2017	Recent studies have delineated cancer-type-specific roles of histone 3 lysine 27 (H3K27) demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity.	Lysine	71-77	lysine demethylase 6B	Homo sapiens	107-112
28759046-5	2017	Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions.	Lysine	132-138	signal transducer and activator of transcription 1	Homo sapiens	246-251
28759046-5	2017	Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions.	Lysine	132-138	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	294-298
28759046-5	2017	Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions.	Lysine	132-138	C-X-C motif chemokine ligand 1	Homo sapiens	313-318
28759046-5	2017	Our data further reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promotes the accessibility of the transcription factor STAT1 to the enhancer and the intron regions of ROS1 target genes, CXCL1 and GLI1, for upregulating their expressions.	Lysine	132-138	GLI family zinc finger 1	Homo sapiens	323-327
29142222-6	2017	The predicted N-terminus amphipathic alpha-helix of ATG3 would be responsible for membrane curvature detection, the positive residues Lys 9 and 11 being essential in the recognition of phospholipid negative moieties.	Lysine	134-137	autophagy related 3	Homo sapiens	52-56
29129908-2	2017	Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis.	Lysine	70-76	tripartite motif containing 24	Homo sapiens	106-136
29129908-2	2017	Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis.	Lysine	70-76	tripartite motif containing 24	Homo sapiens	138-144
28692045-2	2017	KDM3A, a histone H3 lysine 9 (H3K9) demethylase, is known to have a pro-tumorigenic function.	Lysine	20-26	lysine demethylase 3A	Homo sapiens	0-5
29159235-0	2017	Trimethylation of Histone 3 lysine 27 (H3K27me3) ChIP-PCR and transcriptional expression data of Ef1-alpha, cyp26A, HoxC10, HoxD10 and HoxD11 in the Xenopus XTC cell line.	Lysine	28-34	homeobox D11 L homeolog	Xenopus laevis	135-141
29118980-0	2017	SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development.	Lysine	75-81	sirtuin 1	Homo sapiens	0-5
29118980-2	2017	The lysine residue K9 of histone H3 (H3K9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substrates.	Lysine	4-10	sirtuin 1	Homo sapiens	64-69
28784321-2	2017	In this study, the roles of YHM2, ODC1 and ODC2 in the assimilation of nitrogen and in the biosynthesis of lysine have been investigated.	Lysine	107-113	Yhm2p	Saccharomyces cerevisiae S288C	28-32
28784321-9	2017	These results provide evidence that only the simultaneous absence of YHM2, ODC1 and ODC2 impairs the export from the mitochondrial matrix of i) 2-oxoglutarate which is necessary for the synthesis of glutamate and ammonium fixation in the cytosol and ii) 2-oxoadipate which is required for lysine biosynthesis in the cytosol.	Lysine	289-295	Yhm2p	Saccharomyces cerevisiae S288C	69-73
29068315-6	2017	Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2.	Lysine	72-78	SREBF chaperone	Mus musculus	64-68
29068315-6	2017	Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2.	Lysine	72-78	sterol regulatory element binding factor 2	Mus musculus	218-225
29053956-4	2017	Following viral infection, the ubiquitin-binding domain in WHIP bridges RIG-I with MAVS by binding to polyUb chains of RIG-I at lysine 164.	Lysine	128-134	DExD/H-box helicase 58	Homo sapiens	72-77
29053956-4	2017	Following viral infection, the ubiquitin-binding domain in WHIP bridges RIG-I with MAVS by binding to polyUb chains of RIG-I at lysine 164.	Lysine	128-134	DExD/H-box helicase 58	Homo sapiens	119-124
29308302-3	2018	Here, we report that glioma-induced microglia conversion is coupled to an increase of histone H4 lysine 16 (H4K16) acetylation level in microglia, through increased nuclear localization of the deacetylase SIRT1, which in turn results in deacetylation of the H4K16 acetyltransferase hMOF and its recruitment to the chromatin at promoter regions of microglial target genes.	Lysine	97-103	sirtuin 1	Homo sapiens	205-210
28490132-4	2017	On heating, it was found that 1) the two subdomains of BBI were not equally heat stable, 2) the conformation of BBI gradually changed, 3) some amino acid residues (namely, cystine, serine and lysine) in BBI were degraded, 4) BBI did not tend to form intermolecular cross-links with another BBI, but did slightly with non-BBI proteins.	Lysine	192-198	Bowman-Birk type proteinase inhibitor	Glycine max	55-58
28892081-2	2017	Here we show that A20 monoubiquitylates Snail1 at three lysine residues and thereby promotes metastasis of aggressive basal-like breast cancers.	Lysine	56-62	immunoglobulin kappa variable 1-27	Homo sapiens	18-21
28892081-6	2017	Knockdown of A20 or overexpression of Snail1 with mutation of the monoubiquitylated lysine residues into arginine abolishes lung metastasis in mouse xenograft and orthotopic breast cancer models, indicating that A20 and monoubiquitylated Snail1 are required for metastasis.	Lysine	84-90	snail family zinc finger 1	Mus musculus	38-44
28669410-2	2017	Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from partially degraded fibrin, and anti-inflammatory, by downregulating complement anaphylatoxins C3a and C5a.	Lysine	192-198	carboxypeptidase N subunit 1	Homo sapiens	24-49
28669410-2	2017	Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from partially degraded fibrin, and anti-inflammatory, by downregulating complement anaphylatoxins C3a and C5a.	Lysine	192-198	complement C3	Homo sapiens	307-310
28931919-5	2017	RORalpha2 requires lysine specific demethylase 1 (LSD1/KDM1A) as a coactivator for transcriptional activation of RORalpha2 target genes, exemplified by CTNND1.	Lysine	19-25	lysine demethylase 1A	Homo sapiens	50-54
28931919-5	2017	RORalpha2 requires lysine specific demethylase 1 (LSD1/KDM1A) as a coactivator for transcriptional activation of RORalpha2 target genes, exemplified by CTNND1.	Lysine	19-25	lysine demethylase 1A	Homo sapiens	55-60
28928432-7	2017	Lysine biosynthesis is restored when saccharopine dehydrogenase is mislocalised to the cytosol in mdh3/gpd1Delta cells.	Lysine	0-6	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	103-107
28717007-5	2017	Mechanistically, additional results indicated that the RE1-silencing transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter in an NME2-dependent way and that this assembly is required for maintaining repressive chromatin at the hTERT promoter.	Lysine	97-103	lysine demethylase 1A	Homo sapiens	136-140
28816576-3	2017	The lysine specific demethylase KDM2A is a CpG island binding protein that has been studied predominantly for its ability to regulate CpG island-associated gene promoters by demethylating their H3K36me2.	Lysine	4-10	lysine demethylase 2A	Homo sapiens	32-37
28765887-5	2017	In addition, the expression of RP11-713B9.1 was identified to be positively correlated with the expression of tumor suppressors TSLC1, CYLD lysine 63 deubiquitinase and APC WNT signaling pathway regulator, and negatively correlated with B-Raf proto-oncogene serine/threonine kinase expression.	Lysine	140-146	pre-mRNA processing factor 31	Homo sapiens	31-35
28771001-3	2017	Here we demonstrate that mTG can efficiently couple three different acyl-acceptor molecules, l-lysine, glycine ethyl ester, and hydroxylamine, to gliadin peptides and protein.	Lysine	93-101	protease, serine 3	Mus musculus	25-28
28854355-2	2017	Herein, we show that the 70-kDa subunit of RPA (RPA1) is acetylated on lysine 163 by the acetyltransferases GCN5 and PCAF and that such acetylation is reversed principally via the action of the deacetylase HDAC6.	Lysine	71-77	lysine acetyltransferase 2A	Homo sapiens	108-112
28666371-5	2017	By using synthetic peptide mapping and DNA binding screen by electromobility shift assays, we found that FANCD2 bears two major DNA binding domains predominantly consisting of evolutionary conserved lysine residues.	Lysine	199-205	FA complementation group D2	Homo sapiens	105-111
28808264-5	2017	Furthermore, inhibition of MIR31HG reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 (FABP4), leading to suppression of its expression and adipogenesis.	Lysine	96-102	MIR31 host gene	Homo sapiens	27-34
28790335-6	2017	HQ-induced TRPA1 activation was dependent on essential redox-sensitive cysteine and lysine residues within N-terminus of channel protein.	Lysine	84-90	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	11-16
28526709-7	2017	These data indicate that lysine acetylation promotes fatty acid oxidation in the heart and that this modification is regulated in part by the activity of GCN5L1.NEW &amp; NOTEWORTHY Recent research has shown that acetylation of mitochondrial fatty acid oxidation enzymes has greatly contrasting effects on their activity in different tissues.	Lysine	25-31	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	154-160
28550017-0	2017	A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae.	Lysine	2-8	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	47-51
28550017-6	2017	Curiously, both suppressor mutations that were isolated in the Slx5 subunit of the SUMO-targeted Ub ligase created new lysine residues.	Lysine	119-125	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	63-67
28550017-7	2017	These "slx5-K" mutations localize to a 398 amino acid domain that is completely free of lysine, and they result in the auto-ubiquitination and partial proteolysis of Slx5.	Lysine	88-94	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	7-11
28550017-9	2017	This "lysine desert" is found in the subset of large fungal Slx5 proteins, but not its smaller orthologs such as RNF4.	Lysine	6-12	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	60-64
28483947-6	2017	Genetic and pharmacologic approaches were employed to identify a specific role for G9a, a histone methyltransferase (HMT), in promoting methylation of histone H3 lysine-9 (H3K9) mono- and dimethylation, and surprisingly trimethylation, at the USP37 promoter to repress its gene expression.	Lysine	162-168	euchromatic histone lysine methyltransferase 2	Homo sapiens	83-86
28789338-3	2017	HOTAIR mediates the trimethylation of histone H3 at lysine 27 and the demethylation of histone H3 dimethyl Lys4 by recruiting the polycomb repressive complex 2 and the lysine-specific demethylase 1/co-repressor of RE1-silencing transcription factor (coREST)/REST complex to the target gene promoters, which leads to gene silencing.	Lysine	52-58	RE1 silencing transcription factor	Homo sapiens	214-248
28789338-3	2017	HOTAIR mediates the trimethylation of histone H3 at lysine 27 and the demethylation of histone H3 dimethyl Lys4 by recruiting the polycomb repressive complex 2 and the lysine-specific demethylase 1/co-repressor of RE1-silencing transcription factor (coREST)/REST complex to the target gene promoters, which leads to gene silencing.	Lysine	168-174	RE1 silencing transcription factor	Homo sapiens	214-248
28765524-5	2017	Although the recruitment of NF-kappaB p65 was unaffected, the acetylation status of lysine 27 of histone 3, which correlates positively with enhancer activity, was globally increased at PU.1-containing enhancers in Arntl -/- macrophages as compared to wild-type cells.	Lysine	84-90	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	215-220
28637241-6	2017	We also demonstrate that Mer1 expression is dependent on Snf2, its acetylation state and histone H3 lysine 9 acetylation at the MER1 locus.	Lysine	100-106	Mer1p	Saccharomyces cerevisiae S288C	25-29
28637241-6	2017	We also demonstrate that Mer1 expression is dependent on Snf2, its acetylation state and histone H3 lysine 9 acetylation at the MER1 locus.	Lysine	100-106	Mer1p	Saccharomyces cerevisiae S288C	128-132
29088714-2	2017	LSD1 is a flavin-containing AO that specifically catalyzes the demethylation of mono- and di-methylated histone H3 lysine 4 through an FAD-dependent oxidative reaction.	Lysine	115-121	lysine demethylase 1A	Homo sapiens	0-4
28644004-0	2017	Intricate Effects of alpha-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.	Lysine	37-43	H4 clustered histone 9	Homo sapiens	108-118
28644004-5	2017	In this study, we investigated how naturally occurring N-terminal acetylation and PTMs of histone H4 lysine-5 (H4K5) affect arginine-3 methylation catalyzed by both type I and type II PRMTs at the biochemical level.	Lysine	101-107	H4 clustered histone 9	Homo sapiens	90-100
28673974-4	2017	We found that PALB2 associates with active genes through its major binding partner, MRG15, which recognizes histone H3 trimethylated at lysine 36 (H3K36me3) by the SETD2 methyltransferase.	Lysine	136-142	partner and localizer of BRCA2	Homo sapiens	14-19
28673974-4	2017	We found that PALB2 associates with active genes through its major binding partner, MRG15, which recognizes histone H3 trimethylated at lysine 36 (H3K36me3) by the SETD2 methyltransferase.	Lysine	136-142	mortality factor 4 like 1	Homo sapiens	84-89
28619824-2	2017	Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b.	Lysine	10-16	trithorax	Drosophila melanogaster	136-145
28619824-2	2017	Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b.	Lysine	10-16	SET domain containing 1B	Mus musculus	194-200
28483671-8	2017	Activation of MMP-9 by acrolein was inhibited by cysteine, and slightly by lysine, because these amino acids inhibited acrolein conjugation with MMP-9.	Lysine	75-81	matrix metallopeptidase 9	Homo sapiens	14-19
28483671-8	2017	Activation of MMP-9 by acrolein was inhibited by cysteine, and slightly by lysine, because these amino acids inhibited acrolein conjugation with MMP-9.	Lysine	75-81	matrix metallopeptidase 9	Homo sapiens	145-150
28483671-11	2017	These results suggest that activation of 92kDa MMP-9 by acrolein is involved in tissue damage in pSS patients and is regulated by cysteine and histidine, and slightly by lysine.	Lysine	170-176	matrix metallopeptidase 9	Homo sapiens	47-52
28566233-11	2017	Based on the crystal structure we predict that the exchange of glutamate-113 against lysine should induce a strong destabilization of the secondary structure, possibly affecting the folding for correct disulfide bridging between C235-C346 as well as distortion of the active site groove that could affect both the intracellular stability as well as the activity of FGE.	Lysine	85-91	sulfatase modifying factor 1	Homo sapiens	365-368
28300602-4	2017	The Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain is an emerging reader module that selectively recognizes histone lysine acylation with a preference for crotonylation over acetylation.	Lysine	112-118	YEATS domain containing 4	Homo sapiens	4-8
28465486-4	2017	Here we show that SphK2 overexpression contributes to the resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid degradation of cytoplasmic retinoid X receptor alpha (RXRalpha) by lysine 48 (K48)- and lysine 63 (K63)-based polyubiquitination.	Lysine	208-214	retinoid X receptor alpha	Homo sapiens	168-193
28465486-4	2017	Here we show that SphK2 overexpression contributes to the resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid degradation of cytoplasmic retinoid X receptor alpha (RXRalpha) by lysine 48 (K48)- and lysine 63 (K63)-based polyubiquitination.	Lysine	208-214	retinoid X receptor alpha	Homo sapiens	195-203
28465486-4	2017	Here we show that SphK2 overexpression contributes to the resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid degradation of cytoplasmic retinoid X receptor alpha (RXRalpha) by lysine 48 (K48)- and lysine 63 (K63)-based polyubiquitination.	Lysine	229-235	retinoid X receptor alpha	Homo sapiens	195-203
28559311-5	2017	By introducing point mutations into TMEM16F, we found that a lysine in the fourth transmembrane segment of the SCRD as well as an arginine in the third and a glutamic acid in the sixth transmembrane segment were important for exposing phosphatidylserine from the inner to the outer leaflet.	Lysine	61-67	anoctamin 6	Homo sapiens	36-43
28188179-1	2017	Jmjd3 and Utx are demethylases specific for lysine 27 of histone H3.	Lysine	44-50	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	0-5
28258188-0	2017	Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism.	Lysine	0-6	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	42-82
28258188-5	2017	In FAO hepatoma cells, mutation of all 4 lysine residues (4K-R GAPDH) to mimic their unmodified state reduced GAPDH glycolytic activity and glycolytic flux and increased gluconeogenic GAPDH activity and glucose production.	Lysine	41-47	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	63-68
28258188-5	2017	In FAO hepatoma cells, mutation of all 4 lysine residues (4K-R GAPDH) to mimic their unmodified state reduced GAPDH glycolytic activity and glycolytic flux and increased gluconeogenic GAPDH activity and glucose production.	Lysine	41-47	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	110-115
28258188-5	2017	In FAO hepatoma cells, mutation of all 4 lysine residues (4K-R GAPDH) to mimic their unmodified state reduced GAPDH glycolytic activity and glycolytic flux and increased gluconeogenic GAPDH activity and glucose production.	Lysine	41-47	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	110-115
28229514-2	2017	EZH2 and EED are core components of the polycomb repressive complex 2 (PRC2), which possesses histone methyltransferase activity and catalyzes trimethylation of histone H3 at lysine 27.	Lysine	175-181	embryonic ectoderm development	Homo sapiens	9-12
28229514-5	2017	In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased trimethylation of lysine 27 of histone H3.	Lysine	129-135	embryonic ectoderm development	Homo sapiens	62-65
28201649-3	2017	We identify a non-canonical SUMOylation motif termed pSuM that conjugates SUMO2 at Lys-325 of FXR under the direct control of casein kinase 2 (CK2), which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327.	Lysine	83-86	small ubiquitin like modifier 2	Homo sapiens	74-79
28564596-5	2017	We identified the histone variant macroH2A1 from the screen and showed that BRCA1/BARD1 ubiquitinates macroH2A1 at lysine 123 in vitro and in vivo.	Lysine	115-121	BRCA1 DNA repair associated	Homo sapiens	76-81
28564596-5	2017	We identified the histone variant macroH2A1 from the screen and showed that BRCA1/BARD1 ubiquitinates macroH2A1 at lysine 123 in vitro and in vivo.	Lysine	115-121	BRCA1 associated RING domain 1	Homo sapiens	82-87
28509866-7	2017	Furthermore, HDAC8 induced tri-methylation of histone H3 lysine 27 (H3K27me3), which is known to suppress PTEN expression, through at least in part down-regulating the H3K27me3 eraser Jumonji Domain Containing (JMJD) 3.	Lysine	57-63	lysine demethylase 6B	Homo sapiens	184-218
28302717-5	2017	The promoter regions of cell-cycle-related genes and Foxm1 acquired higher levels of trimethylated histone H3 Lys-4, suggesting that epigenetic regulations of these key regulatory genes define quiescence and regeneration of the liver cells.	Lysine	110-113	forkhead box M1	Homo sapiens	53-58
28521610-8	2017	In response to S1P stimulation, TRAF2 bound to BECN1/Beclin 1 and catalyzed the lysine 63-linked ubiquitination of BECN1 for triggering autophagy.	Lysine	80-86	TNF receptor associated factor 2	Homo sapiens	32-37
28521610-8	2017	In response to S1P stimulation, TRAF2 bound to BECN1/Beclin 1 and catalyzed the lysine 63-linked ubiquitination of BECN1 for triggering autophagy.	Lysine	80-86	beclin 1	Homo sapiens	53-61
28521610-8	2017	In response to S1P stimulation, TRAF2 bound to BECN1/Beclin 1 and catalyzed the lysine 63-linked ubiquitination of BECN1 for triggering autophagy.	Lysine	80-86	beclin 1	Homo sapiens	115-120
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	104-110	mediator complex subunit 1	Homo sapiens	235-239
28475875-3	2017	The establishment of new promoter-enhancer loops is tightly coupled to activation of poised (histone H3 lysine 4 mono- and dimethylated) enhancers, as evidenced by the acquisition of histone H3 lysine 27 acetylation and the binding of MED1, SMC1, and P300 proteins to these regions, as well as to activation of target genes.	Lysine	194-200	mediator complex subunit 1	Homo sapiens	235-239
28355486-10	2017	Similar to P450 11B1, P450 11B2 also forms a complex with the Adx dimer via three lysine residues.	Lysine	82-88	ferredoxin 1	Homo sapiens	62-65
28416760-3	2017	ChIP-Seq experiments monitoring histone 3 lysine 9 (H3K9) methylation marks show global histone demethylation effects of KDM3A.	Lysine	42-48	lysine demethylase 3A	Homo sapiens	121-126
28418861-3	2017	Accordingly, morphine in CRC cells will stimulate the expression of its main metabolic enzyme, UGT2B7 during tolerance generation by activating the positive signals in histone 3, especially for trimethylated lysine 27 (H3K4Me3) and acetylated lysine 4 (H3K27Ac).	Lysine	208-214	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	95-101
28418861-3	2017	Accordingly, morphine in CRC cells will stimulate the expression of its main metabolic enzyme, UGT2B7 during tolerance generation by activating the positive signals in histone 3, especially for trimethylated lysine 27 (H3K4Me3) and acetylated lysine 4 (H3K27Ac).	Lysine	243-249	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	95-101
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	DnaJ heat shock protein family (Hsp40) member A1	Sus scrofa	183-189
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	ubiquitin conjugating enzyme E2 B	Sus scrofa	204-209
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	Rho family GTPase 3	Sus scrofa	274-278
28430144-5	2017	Ingenuity pathway analysis showed that dietary lysine deficiency may lead to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 and ZIC1 mRNA; (3) increased serine and glycine synthesis via the up-regulated PHGDH and PSPH mRNA; and (4) increased lipid accumulation via the up-regulated ME1, SCD, and CIDEC mRNA.	Lysine	47-53	phosphoserine phosphatase	Sus scrofa	368-372
28275114-5	2017	This is reversed by proteasome inhibition, depletion of endogenous Dok-4 or lysine-to-arginine mutation of putative Elk-4 ubiquitination sites.	Lysine	76-82	ETS transcription factor ELK4	Canis lupus familiaris	116-121
28176353-4	2017	TRPA1 and TRPV1 channels are activated by intracellular LPA, but not by extracellular LPA following LPA5 receptor activation with an activity of Ca2+ -independent phospholipase A2 and phospholipase D. Intracellular LPA interaction sites of TRPA1 are KK672-673 and KR977-978 (K: lysine, R: arginine).	Lysine	278-284	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
28443098-1	2017	G9a (KMT1C, EHMT2) is a lysine methyltransferase (KMT) whose primary function is to di-methylate lysine 9 of histone H3 (H3K9me2).	Lysine	24-30	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
28443098-1	2017	G9a (KMT1C, EHMT2) is a lysine methyltransferase (KMT) whose primary function is to di-methylate lysine 9 of histone H3 (H3K9me2).	Lysine	24-30	euchromatic histone lysine methyltransferase 2	Homo sapiens	5-10
28443098-1	2017	G9a (KMT1C, EHMT2) is a lysine methyltransferase (KMT) whose primary function is to di-methylate lysine 9 of histone H3 (H3K9me2).	Lysine	24-30	euchromatic histone lysine methyltransferase 2	Homo sapiens	12-17
28428755-7	2017	We show that antagonists of 5-HT1D and 5-HT2C receptor subtypes were able to do so (LY 310762 and SB 242084, respectively), but notably, a 5-HT2A-antagonist (ketanserin) was not.	Lysine	84-86	5-hydroxytryptamine receptor 1D	Homo sapiens	28-34
28380357-3	2017	In the present study, we find that Keap1/Cullin3 ubiquitinates p62 at lysine 420 within its UBA domain.	Lysine	70-76	sequestosome 1	Homo sapiens	63-66
28380357-8	2017	These data suggest that the ubiquitination of p62"s UBA domain at lysine 420 may regulate p62"s function and be disrupted in p62-associated disease.	Lysine	66-72	sequestosome 1	Homo sapiens	46-49
28380357-8	2017	These data suggest that the ubiquitination of p62"s UBA domain at lysine 420 may regulate p62"s function and be disrupted in p62-associated disease.	Lysine	66-72	sequestosome 1	Homo sapiens	90-93
28380357-8	2017	These data suggest that the ubiquitination of p62"s UBA domain at lysine 420 may regulate p62"s function and be disrupted in p62-associated disease.	Lysine	66-72	sequestosome 1	Homo sapiens	90-93
28223321-1	2017	Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone-H3 (H3K27me3) as part of the polycomb repressive complex 2 (PRC2) together with Suz12 and Eed.	Lysine	45-51	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	21-25
28223321-1	2017	Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone-H3 (H3K27me3) as part of the polycomb repressive complex 2 (PRC2) together with Suz12 and Eed.	Lysine	45-51	H3 clustered histone 7	Mus musculus	58-68
28260048-7	2017	In turn, the interaction between ZAC and P300 increased the activity of P300-HAT; ultimately, the phosphorylation of serine 10 in histone H3 (pS10-H3) was decreased and the acetylation of lysine 14 in histone H3 (acK14-H3) was increased.	Lysine	188-194	PLAG1 like zinc finger 1	Homo sapiens	33-36
28092155-3	2017	EED, another subunit of PRC2 complex, is essential for its histone methyltransferase activity through direct binding to trimethylated lysine 27 on histone 3 (H3K27Me3).	Lysine	134-140	embryonic ectoderm development	Homo sapiens	0-3
28426094-7	2017	SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation.	Lysine	47-53	sirtuin 7	Homo sapiens	0-5
28426094-7	2017	SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation.	Lysine	47-53	lysine acetyltransferase 2A	Homo sapiens	18-22
28159901-10	2017	Furthermore, 53BP1 chromatin occupancy at sites in the Igh locus is B cell specific, is correlated with histone H4 lysine 20 marks, and is subject to chromatin spreading.	Lysine	115-121	immunoglobulin heavy chain complex	Mus musculus	55-58
28262751-2	2017	Utilizing mouse embryonic fibroblast and cancer cell line models, here we show via ChIP-seq and biochemical assays that SWI/SNF complexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to modulate histone H3 lysine 27 acetylation.	Lysine	249-255	E1A binding protein p300	Mus musculus	221-225
28262837-7	2017	HDAC-mediated suppression of FBP1 expression correlated with decreased histone H3 lysine 27 acetylation (H3K27Ac) in the FBP1 enhancer.	Lysine	82-88	fructose-bisphosphatase 1	Homo sapiens	29-33
28262837-7	2017	HDAC-mediated suppression of FBP1 expression correlated with decreased histone H3 lysine 27 acetylation (H3K27Ac) in the FBP1 enhancer.	Lysine	82-88	fructose-bisphosphatase 1	Homo sapiens	121-125
28096463-8	2017	We find that AXR1 as well as other neddylation enzymes are autoneddylated at multiple lysines.	Lysine	86-93	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	13-17
28257421-5	2017	We found that alpha-synuclein is acetylated on lysines 6 and 10 and that these residues are deacetylated by sirtuin 2.	Lysine	47-54	synuclein alpha	Rattus norvegicus	14-29
28110910-9	2017	Importantly, using lysine-mutated forms of TCTP, we show that acetylation of Lysine 19 generates a KFERQ-like motif and promotes binding to Hsc70, lysosome targeting and TCTP degradation by CMA.	Lysine	19-25	heat shock protein family A (Hsp70) member 8	Homo sapiens	140-145
28110910-9	2017	Importantly, using lysine-mutated forms of TCTP, we show that acetylation of Lysine 19 generates a KFERQ-like motif and promotes binding to Hsc70, lysosome targeting and TCTP degradation by CMA.	Lysine	77-83	heat shock protein family A (Hsp70) member 8	Homo sapiens	140-145
28069602-3	2017	Here, we identified the lysine-specific demethylase KDM1A as a novel interaction partner of ZEB2 and demonstrated that mouse and human T-ALLs with increased ZEB2 levels critically depend on KDM1A activity for survival.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	190-195
27993971-9	2017	Substituting Lys residues at positions 116 and 144/148 of CD81 EC2 in the predicted integrin-binding interface reduced the binding of CD81 EC2 to alphavbeta3, consistent with the docking model.	Lysine	13-16	CD81 molecule	Homo sapiens	58-62
27993971-9	2017	Substituting Lys residues at positions 116 and 144/148 of CD81 EC2 in the predicted integrin-binding interface reduced the binding of CD81 EC2 to alphavbeta3, consistent with the docking model.	Lysine	13-16	CD81 molecule	Homo sapiens	134-138
27894088-1	2017	Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers.	Lysine	81-87	lysine demethylase 1A	Homo sapiens	0-29
27894088-1	2017	Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers.	Lysine	81-87	lysine demethylase 1A	Homo sapiens	31-35
27894088-1	2017	Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers.	Lysine	101-107	lysine demethylase 1A	Homo sapiens	0-29
27894088-1	2017	Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers.	Lysine	101-107	lysine demethylase 1A	Homo sapiens	31-35
28137876-0	2017	Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.	Lysine	19-25	src homology 2 domain-containing transforming protein C1	Mus musculus	41-47
28137876-5	2017	Using diabetes as an oxidative stimulus, we demonstrate that p66Shc is acetylated under high glucose conditions and is deacetylated by Sirt1 on lysine 81.	Lysine	144-150	src homology 2 domain-containing transforming protein C1	Mus musculus	61-67
28137876-6	2017	High glucose-stimulated lysine acetylation of p66Shc facilitates its phosphorylation on serine 36 and translocation to the mitochondria, where it promotes hydrogen peroxide production.	Lysine	24-30	src homology 2 domain-containing transforming protein C1	Mus musculus	46-52
26898636-8	2017	Increasing dietary lysine content linearly increased (p &lt; 0.05) ADG and G:F. In experiment 2, 90 piglets were housed three per pen and allocated to five dietary treatments with six replicates per treatment.	Lysine	19-25	ADG	Sus scrofa	67-70
26898636-10	2017	Increasing dietary lysine content linearly increased (p &lt; 0.05) G:F, linearly decreased (p &lt; 0.05) day-14 PUN and quadratically (p &lt; 0.05) increased ADG and ADFI.	Lysine	19-25	ADG	Sus scrofa	158-161
27895153-6	2017	Attenuation of Ku80 ubiquitylation by replacement of ubiquitylation site lysines with arginine residues delayed Ku70/80 release from chromatin after DSB induction by genotoxic insults.	Lysine	73-80	X-ray repair cross complementing 6	Homo sapiens	112-116
28017567-4	2017	The drug is attached to the lysine residue through a peptidic, hydrolytically stable, cathepsin B cleavable linker.	Lysine	28-34	cathepsin B	Homo sapiens	86-97
27845897-1	2017	The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3.	Lysine	183-189	embryonic ectoderm development	Homo sapiens	83-86
27902479-5	2017	T521 exhibits covalent binding to some lysine residues of Plk1 PBD, which causes significant changes in the secondary structure of Plk1 PBD.	Lysine	39-45	polo like kinase 1	Homo sapiens	58-62
27902479-5	2017	T521 exhibits covalent binding to some lysine residues of Plk1 PBD, which causes significant changes in the secondary structure of Plk1 PBD.	Lysine	39-45	polo like kinase 1	Homo sapiens	131-135
28045381-11	2017	In native human ALAD, the A monomer also has a ligand resembling the substrate ALA which is covalently bound by a Schiff base to one of the active-site lysines (Lys252) and is held in place by an ordered active-site loop.	Lysine	152-159	aminolevulinate dehydratase	Homo sapiens	16-20
28849491-2	2017	Ala, Gln, Gly, Lys, Val and taurine (Tau) are the most abundant free AAs in mammals, and some of these react with hypochlorite (HOCl/OCl-) produced by myeloperoxidase in activated phagocytes to form N-chloroamino acids (NCAA).	Lysine	15-18	myeloperoxidase	Mus musculus	151-166
28486922-1	2017	BACKGROUND: In the past few years, great of attention has been paid to the identification and characterization of selective and potent inhibitors of the first identified histone demethylase LSD1, which may erase mono- and di-methylated histone 3 lysine 4 and 9.	Lysine	246-252	lysine demethylase 1A	Homo sapiens	190-194
28002468-0	2016	Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.	Lysine	10-16	microtubule associated protein 2	Homo sapiens	77-81
28002468-4	2016	We identify a cluster of lysines in the MAP2 and MAP4 MTBR that undergo CBP-catalyzed acetylation, many of which are conserved in tau.	Lysine	25-32	microtubule associated protein 2	Homo sapiens	40-44
28002468-4	2016	We identify a cluster of lysines in the MAP2 and MAP4 MTBR that undergo CBP-catalyzed acetylation, many of which are conserved in tau.	Lysine	25-32	microtubule associated protein 4	Homo sapiens	49-53
27798241-3	2016	The cohesiveness of cohesin is promoted by acetylation of N-terminal lysines of the Smc3 subunit by the acetyltransferases Eco1 in Saccharomyces cerevisiae and the homologue, Eso1, in Schizosaccharomyces pombe.	Lysine	69-76	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	84-88
27798241-3	2016	The cohesiveness of cohesin is promoted by acetylation of N-terminal lysines of the Smc3 subunit by the acetyltransferases Eco1 in Saccharomyces cerevisiae and the homologue, Eso1, in Schizosaccharomyces pombe.	Lysine	69-76	Eco1p	Saccharomyces cerevisiae S288C	123-127
27951654-3	2016	We demonstrate that TDG interacts with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23).	Lysine	114-121	thymine DNA glycosylase	Mus musculus	20-23
27951654-3	2016	We demonstrate that TDG interacts with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23).	Lysine	114-121	E1A binding protein p300	Mus musculus	57-61
27951654-3	2016	We demonstrate that TDG interacts with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23).	Lysine	114-121	E1A binding protein p300	Mus musculus	88-92
27934968-4	2016	Hypoxia induces K63-linked polyubiquitinated HAUSP at lysine 443 to enhance its functions.	Lysine	54-60	ubiquitin specific peptidase 7	Homo sapiens	45-50
27934968-5	2016	Knockdown of HAUSP decreases acetylation of histone 3 lysine 56 (H3K56Ac).	Lysine	54-60	ubiquitin specific peptidase 7	Homo sapiens	13-18
27371368-7	2016	The reduced expression of miR-375 was accompanied by cytosine DNA hypermethylation and increased lysine methylation of histone H3K9 and H3K27 at the MiR-375 gene.	Lysine	97-103	microRNA 375	Rattus norvegicus	26-33
27371368-7	2016	The reduced expression of miR-375 was accompanied by cytosine DNA hypermethylation and increased lysine methylation of histone H3K9 and H3K27 at the MiR-375 gene.	Lysine	97-103	microRNA 375	Rattus norvegicus	149-156
27735137-1	2016	Methylation of histone H3 lysine 4 is linked to active transcription and can be removed by LSD1 or the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively.	Lysine	26-32	lysine demethylase 1A	Homo sapiens	91-95
27808481-6	2016	We demonstrated that RNF167 ubiquitinates Arl8B at the lysine residue K141 and reduces the level of the Arl8B protein.	Lysine	55-61	ring finger protein 167	Homo sapiens	21-27
27808481-6	2016	We demonstrated that RNF167 ubiquitinates Arl8B at the lysine residue K141 and reduces the level of the Arl8B protein.	Lysine	55-61	ADP ribosylation factor like GTPase 8B	Homo sapiens	42-47
27766492-4	2016	Fe(II) DGCR8 RNA-binding heme domain (Rhed) undergoes a pH-dependent transition from 6-coordinate to 5-coordinate, due to protonation and loss of a lysine ligand; the ligand bound throughout the pH change is a histidine.	Lysine	148-154	DGCR8 microprocessor complex subunit	Homo sapiens	7-12
27783990-3	2016	USP9X binds beta-catenin and removes the Lys 48-linked polyubiquitin chains that normally mark beta-catenin for proteasomal degradation.	Lysine	41-44	ubiquitin specific peptidase 9 X-linked	Homo sapiens	0-5
27897169-1	2016	Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression.	Lysine	86-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	36-40
27783504-9	2016	PBGS active site chemistry benefits from a closed lid because porphobilinogen biosynthesis includes Schiff base formation, which requires deprotonated lysine amino groups.	Lysine	151-157	aminolevulinate dehydratase	Homo sapiens	0-4
27834370-4	2016	AUX1 expression and histone H3 acetylation at lysines 9 and 18 is regulated by SNL1 and SNL2.	Lysine	46-53	SIN3-like 2	Arabidopsis thaliana	88-92
27819261-5	2016	We show that SIRT1 interacts with the C-terminus of Nkx2.5 and deacetylates Nkx2.5 at lysine 182 in the homeodomain.	Lysine	86-92	sirtuin 1	Homo sapiens	13-18
27812120-4	2016	OxPAPC agonist activity was dependent on essential cysteine and lysine residues within the N-terminus of the TRPA1 channel protein.	Lysine	64-70	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	109-114
27581978-12	2016	Replacing D101 with glycine and R167 with lysine in NL4-3 Vif impaired its counteractivity to A3F and A3C.	Lysine	42-48	Vif	Human immunodeficiency virus 1	58-61
27581978-12	2016	Replacing D101 with glycine and R167 with lysine in NL4-3 Vif impaired its counteractivity to A3F and A3C.	Lysine	42-48	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	Homo sapiens	102-105
27670594-9	2016	Mechanistically, VSMC-SIRT1-dependent deacetylation of histone H3 lysine 9 on the matrix metallopeptidase 2 (Mmp2) promoter was required for CR-mediated suppression of AngII-induced MMP2 expression.	Lysine	66-72	matrix metallopeptidase 2	Mus musculus	82-107
27670594-9	2016	Mechanistically, VSMC-SIRT1-dependent deacetylation of histone H3 lysine 9 on the matrix metallopeptidase 2 (Mmp2) promoter was required for CR-mediated suppression of AngII-induced MMP2 expression.	Lysine	66-72	matrix metallopeptidase 2	Mus musculus	109-113
27546596-6	2016	Thus, specific host-guest chemistry between aggregation-prone proteins and lysine/arginine binders rescues cell viability and restores animal health in models of AD, PD, and TTR amyloidosis.	Lysine	75-81	transthyretin	Homo sapiens	174-177
27573245-5	2016	We identified three ubiquitylated lysine residues and showed that DNA ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cul4-DDB1 complex.	Lysine	34-40	damage specific DNA binding protein 1	Homo sapiens	173-177
27569044-2	2016	In humans, attachment of ubiquitin to lysine 120 of histone H2B depends on the activity of the E2 ubiquitin-conjugating enzyme, Ube2B, and the really interesting new gene (RING) E3 ligases, RING finger protein (RNF) 20 and RNF40.	Lysine	38-44	ubiquitin conjugating enzyme E2 B	Homo sapiens	128-133
27705745-4	2016	In mouse embryonic stem cells, RYBP plays a central role in shaping H2AK119 mono-ubiquitylation at PcG targets and underpins an activity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required for normal histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	251-257	chromobox 2	Mus musculus	174-182
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	168-179
27128386-2	2016	In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/beta-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl).	Lysine	125-131	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	181-184
27351433-1	2016	Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged as an important oncogene that regulates key cellular processes including apoptosis, migration, invasion, proliferation, and differentiation.	Lysine	71-77	CEA cell adhesion molecule 1	Rattus norvegicus	83-90
27535225-0	2016	The Eaf3/5/7 Subcomplex Stimulates NuA4 Interaction with Methylated Histone H3 Lys-36 and RNA Polymerase II.	Lysine	79-82	Eaf3p	Saccharomyces cerevisiae S288C	4-8
27535225-4	2016	The Eaf3/5/7 complex and the Rpd3C(S) histone deacetylase complex have both been shown to bind di- and trimethylated histone H3 Lys-36 stimulated by Eaf3.	Lysine	128-131	Eaf3p	Saccharomyces cerevisiae S288C	4-8
27535225-4	2016	The Eaf3/5/7 complex and the Rpd3C(S) histone deacetylase complex have both been shown to bind di- and trimethylated histone H3 Lys-36 stimulated by Eaf3.	Lysine	128-131	Eaf3p	Saccharomyces cerevisiae S288C	149-153
27535225-8	2016	In vitro binding assays showed that Eaf3/5/7 specifically stimulates NuA4 binding to di- and trimethylated histone H3 Lys-36 and that this binding is important for NuA4 occupancy in transcribed ORFs.	Lysine	118-121	Eaf3p	Saccharomyces cerevisiae S288C	36-40
27573846-2	2016	To study these interactions in vivo, we generated a germline deletion of MORF-related gene on chromosome 15 (MRG15), a multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells.	Lysine	191-197	mortality factor 4 like 1	Homo sapiens	73-107
27573846-2	2016	To study these interactions in vivo, we generated a germline deletion of MORF-related gene on chromosome 15 (MRG15), a multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells.	Lysine	191-197	mortality factor 4 like 1	Homo sapiens	109-114
27449519-0	2016	Evidence for Regulation of ECM3 Expression by Methylation of Histone H3 Lysine 4 and Intergenic Transcription in Saccharomyces cerevisiae.	Lysine	72-78	putative ATPase ECM3	Saccharomyces cerevisiae S288C	27-31
27449519-5	2016	Because noncoding transcription can lead to changes in the local chromatin landscape that impinge on the expression of nearby coding genes, we surveyed the effects of various chromatin regulators on the expression of ECM3 These analyses identified roles for the Paf1 complex in positively regulating ECM3 transcription through methylation of histone H3 at lysine 4 (K4) and for Paf1 in controlling the pattern of intergenic transcription at this locus.	Lysine	356-362	putative ATPase ECM3	Saccharomyces cerevisiae S288C	217-221
27586085-7	2016	Deacetylase SIRT2 promotes NADPH production through deacetylating G6PD at lysine 403 (K403).	Lysine	74-80	glucose-6-phosphate dehydrogenase	Homo sapiens	66-70
27590064-7	2016	Lys(181) located in the Exo70A1 hypervariable region may be the ubiquitination site mediating the interaction between ARC1 and Exo70A1.	Lysine	0-3	exocyst complex component EXO70A1	Brassica oleracea	24-31
27590064-7	2016	Lys(181) located in the Exo70A1 hypervariable region may be the ubiquitination site mediating the interaction between ARC1 and Exo70A1.	Lysine	0-3	exocyst complex component EXO70A1	Brassica oleracea	127-134
27588112-3	2016	The current study aimed to investigate the effect of histone H4 lysine 5 (H4K5) modifications on the BRG1 gene in brain tissue of the ventral tegmental area (VTA) of heroin-addicted rats.	Lysine	64-70	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Rattus norvegicus	101-105
27406784-4	2016	Transgenic lines overexpressing a mutated form of CRK5, CRK5 (K372E) with the change of the 372nd conserved amino acid residue from lysine to glutamic acid in its kinase domain, result in wild-type ABA and drought responses, supporting the role of CRK5 in ABA signaling.	Lysine	132-138	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	50-54
27406784-4	2016	Transgenic lines overexpressing a mutated form of CRK5, CRK5 (K372E) with the change of the 372nd conserved amino acid residue from lysine to glutamic acid in its kinase domain, result in wild-type ABA and drought responses, supporting the role of CRK5 in ABA signaling.	Lysine	132-138	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	56-60
27406784-4	2016	Transgenic lines overexpressing a mutated form of CRK5, CRK5 (K372E) with the change of the 372nd conserved amino acid residue from lysine to glutamic acid in its kinase domain, result in wild-type ABA and drought responses, supporting the role of CRK5 in ABA signaling.	Lysine	132-138	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	56-60
27570077-1	2016	The Doa10 quality control ubiquitin (Ub) ligase labels proteins with uniform lysine 48-linked poly-Ub (K48-pUB) chains for proteasomal degradation.	Lysine	77-83	membrane associated ring-CH-type finger 6	Homo sapiens	4-9
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	SRY-box transcription factor 2	Homo sapiens	180-184
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	49-52	SRY-box transcription factor 2	Homo sapiens	222-226
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	SRY-box transcription factor 2	Homo sapiens	180-184
27369080-2	2016	Here, we revealed that the highly conserved Oct4/Lys-156 is important for maintaining the stability of the Oct4 protein and the intermolecular salt bridge between Oct4/Lys-151 and Sox2/Asp-107 that contributes to the Oct4/Sox2 interaction.	Lysine	168-171	SRY-box transcription factor 2	Homo sapiens	222-226
27095675-8	2016	Ionic hydrogen bonds between the carboxylate group in phosphatidylserine and several lysine residues in the C-terminal region of RecA stabilize the parallel ( ) binding orientation, which is not locally stable on PG- and CL-containing membranes despite similarity in the overall charge density.	Lysine	85-91	RAD51 recombinase	Homo sapiens	129-133
27177841-2	2016	The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (+-0.3) x 10(4) M(-1) s(-1) and 2.4 (+-0.3) x 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively.	Lysine	66-69	ADAM metallopeptidase domain 17	Homo sapiens	181-187
27188525-0	2016	Structure-function characterization of the human mitochondrial thiamin pyrophosphate transporter (hMTPPT; SLC25A19): Important roles for Ile(33), Ser(34), Asp(37), His(137) and Lys(291).	Lysine	177-180	solute carrier family 25 member 19	Homo sapiens	106-114
26896487-0	2016	ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.	Lysine	63-69	zinc finger and BTB domain containing 7B	Mus musculus	0-5
26896487-0	2016	ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.	Lysine	63-69	CXXC finger 5	Mus musculus	16-21
26896487-5	2016	We found that CD40 ligand expression is moderately induced by retroviral Thpok transduction into CD8(+) cytotoxic T cells, which was accompanied by a reduction of histone H3 lysine 9 methylation and histone H3 lysine 27 methylation in the promoter region of the Cd40lg gene.	Lysine	174-180	zinc finger and BTB domain containing 7B	Mus musculus	73-78
26896487-5	2016	We found that CD40 ligand expression is moderately induced by retroviral Thpok transduction into CD8(+) cytotoxic T cells, which was accompanied by a reduction of histone H3 lysine 9 methylation and histone H3 lysine 27 methylation in the promoter region of the Cd40lg gene.	Lysine	210-216	zinc finger and BTB domain containing 7B	Mus musculus	73-78
26896487-6	2016	Th-inducing pox virus and zinc finger/Kruppel-like factor directly inhibited the expression of murine CXXC5, a CXXC-type zinc finger protein that induced histone H3 lysine 9 methylation, in part, through an interaction with the histone-lysine N-methyltransferase SUV39H1.	Lysine	165-171	CXXC finger 5	Mus musculus	102-107
27268279-6	2016	PKN1 or WDR5 knockdown severely inhibited KAT8 association with AR target genes and histone H4 lysine 16 acetylation upon androgen treatment.	Lysine	95-101	protein kinase N1	Homo sapiens	0-4
27277658-1	2016	Lysine-specific histone demethylase 1 (LSD1) is an essential epigenetic regulator in metazoans and requires the co-repressor element-1 silencing transcription factor (CoREST) to efficiently catalyze the removal of mono- and dimethyl functional groups from histone 3 at lysine positions 4 and 9 (H3K4/9).	Lysine	269-275	lysine demethylase 1A	Homo sapiens	0-37
27277658-1	2016	Lysine-specific histone demethylase 1 (LSD1) is an essential epigenetic regulator in metazoans and requires the co-repressor element-1 silencing transcription factor (CoREST) to efficiently catalyze the removal of mono- and dimethyl functional groups from histone 3 at lysine positions 4 and 9 (H3K4/9).	Lysine	269-275	lysine demethylase 1A	Homo sapiens	39-43
27468310-10	2016	CONCLUSIONS: Substitution of N-terminal lysine residues in the endogenous hexose transporters Hxt1 and Hxt36 that are subjected to catabolite degradation results in improved retention at the cytoplasmic membrane in the absence of glucose and causes improved xylose fermentation upon the depletion of glucose and when cells are grown in d-xylose alone.	Lysine	40-46	hexose transporter HXT1	Saccharomyces cerevisiae S288C	94-98
27092849-6	2016	In the paralogues OR1A1 and OR1A2, the aldehydes tend to interact in the top region of the binding pocket and close to a positively charged lysine.	Lysine	140-146	olfactory receptor family 1 subfamily A member 1	Homo sapiens	18-23
27118868-4	2016	In the present study, we show that EBP1 binds directly to several PPIns via two distinct PPIn-binding sites consisting of clusters of lysine residues and positioned at the N- and C-termini of the protein.	Lysine	134-140	proliferation-associated 2G4	Homo sapiens	35-39
27225932-2	2016	The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N-terminal tail of histone H3 (H3K18Ac), thus modulating chromatin structure and transcriptional competency.	Lysine	73-79	sirtuin 7	Mus musculus	48-53
26640146-5	2016	ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 lysine 4, 9 and 27.	Lysine	188-194	lysine demethylase 1A	Homo sapiens	67-71
27391593-3	2016	In the present study, we introgressed the opaque2 (o2) allele into waxy maize line Zhao OP-6/O2O2 by using marker-assisted selection (MAS) technique and successfully improved the lysine content and quality of waxy maize.	Lysine	179-185	regulatory protein opaque-2	Zea mays	42-49
27391593-3	2016	In the present study, we introgressed the opaque2 (o2) allele into waxy maize line Zhao OP-6/O2O2 by using marker-assisted selection (MAS) technique and successfully improved the lysine content and quality of waxy maize.	Lysine	179-185	regulatory protein opaque-2	Zea mays	51-53
27243212-5	2016	Dimethylation of histone H3 lysine 4 (H3K4), a mark of transcriptional activation, was predominantly found in the proximal TIM-3 promoter -954 to -34bp region, whereas trimethylation of H3K9 and H3K27, which are markers of transcriptional suppression, were mostly observed in the distal promoter -1549 to -1048bp region in human CD4(+) T cells and CD11b(+) cells.	Lysine	28-34	hepatitis A virus cellular receptor 2	Homo sapiens	123-128
27174920-3	2016	Inhibition of EHMT2 reduced dimethylation of lysine 9 on histone H3 (H3K9me2) and dissociated EHMT2 and H3K9me2 from the promoter of Beclin-1.	Lysine	45-51	euchromatic histone lysine methyltransferase 2	Homo sapiens	14-19
27242167-1	2016	The import of acetyl-CoA into the lumen of the endoplasmic reticulum (ER) by AT-1/SLC33A1 regulates Nepsilon-lysine acetylation of ER-resident and -transiting proteins.	Lysine	109-115	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	77-81
27242167-1	2016	The import of acetyl-CoA into the lumen of the endoplasmic reticulum (ER) by AT-1/SLC33A1 regulates Nepsilon-lysine acetylation of ER-resident and -transiting proteins.	Lysine	109-115	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	82-89
27337104-2	2016	Lysine demethylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respectively), proceeds via oxidation of the N-methyl group, resulting in the release of formaldehyde.	Lysine	0-6	lysine demethylase 1A	Homo sapiens	96-100
27606339-2	2016	The activity of G9a, the enzyme responsible for mono- and di-methylation of lysine 9 on histone H3 (H3K9me1 and H3K9me2) in mammalian euchromatin, has been widely implicated in the differentiation of a variety of cell types and tissues.	Lysine	76-82	euchromatic histone lysine methyltransferase 2	Homo sapiens	16-19
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	Nanog homeobox	Homo sapiens	207-212
26481420-7	2016	Chromatin immunoprecipitation (ChIP) coupled with real-time PCR showed significant changes in the acetylation and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-gamma, Lpl, adiponectin) marker genes in undifferentiated MSCs, FBS and AS.	Lysine	138-144	SRY-box transcription factor 2	Homo sapiens	214-218
27209302-5	2016	Using mass spectrometry analysis, we firstly confirmed acetylation as a previously unreported modification of TFEB and found that SIRT1 directly interacted with and deacetylated TFEB at lysine residue 116.	Lysine	186-192	transcription factor EB	Mus musculus	178-182
26679521-5	2016	We find that the SUMO-E2 conjugating enzyme Ubc9 and the SUMO E3 ligase PIAS3 associate with Smurf2 and promote its sumoylation at the distinct sites of Lysines 26 and 369.	Lysine	153-160	ubiquitin-conjugating enzyme E2I	Mus musculus	44-48
26851501-4	2016	In some instances, these local deficits were associated with an increased susceptibility to transcriptional dysregulation (e.g., Camk1g and Rasl11b) and the defective trimethylation of histone H3 at lysine 4 (H3K4me3), another covalent modification of histone tails that is related to active transcription and is also altered in HD.	Lysine	199-205	H3 clustered histone 7	Mus musculus	185-195
26929405-3	2016	We show that AtMETTL20, analogous to the human enzyme, methylates ETFbeta on Lys-193 and Lys-196 both in vitro and in vivo ETF plays a key role in mediating electron transfer from various dehydrogenases, and we found that its electron transferring ability was diminished by AtMETTL20-mediated methylation of ETFbeta.	Lysine	77-80	electron transfer flavoprotein subunit beta	Homo sapiens	66-73
26929405-3	2016	We show that AtMETTL20, analogous to the human enzyme, methylates ETFbeta on Lys-193 and Lys-196 both in vitro and in vivo ETF plays a key role in mediating electron transfer from various dehydrogenases, and we found that its electron transferring ability was diminished by AtMETTL20-mediated methylation of ETFbeta.	Lysine	77-80	electron transfer flavoprotein subunit beta	Homo sapiens	308-315
26929405-3	2016	We show that AtMETTL20, analogous to the human enzyme, methylates ETFbeta on Lys-193 and Lys-196 both in vitro and in vivo ETF plays a key role in mediating electron transfer from various dehydrogenases, and we found that its electron transferring ability was diminished by AtMETTL20-mediated methylation of ETFbeta.	Lysine	89-92	electron transfer flavoprotein subunit beta	Homo sapiens	308-315
26929405-4	2016	Somewhat surprisingly, AtMETTL20 also catalyzed monomethylation of RpL7/L12 on Lys-86, a common modification also found in many bacteria that lack METTL20.	Lysine	79-82	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	25-32
26929405-7	2016	Moreover, the present work establishes METTL20-mediated methylation of ETFbeta as the first lysine methylation event occurring in both bacteria and humans.	Lysine	92-98	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	39-46
26929405-7	2016	Moreover, the present work establishes METTL20-mediated methylation of ETFbeta as the first lysine methylation event occurring in both bacteria and humans.	Lysine	92-98	electron transfer flavoprotein subunit beta	Homo sapiens	71-78
26934917-0	2016	Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen.	Lysine	75-81	peptidylprolyl isomerase B	Mus musculus	0-13
26934917-5	2016	Here we report that although CypB deficiency resulted in lower lysine hydroxylation in the helical cross-linking sites, it was increased in the telopeptide cross-linking sites in tendon type I collagen.	Lysine	63-69	peptidylprolyl isomerase B	Mus musculus	29-33
26934917-11	2016	The data indicate that CypB modulates collagen cross-linking by differentially affecting lysine hydroxylation in a site-specific manner, possibly via its interaction with lysyl hydroxylases and associated molecules.	Lysine	89-95	peptidylprolyl isomerase B	Mus musculus	23-27
26951750-3	2016	X-ray crystallography has revealed that the benzyloxy moiety interacts with a lysine cation of the IGF-1R kinase domain via its ether function and its aromatic pi-system and is nicely embedded in an induced hydrophobic pocket.	Lysine	78-84	insulin like growth factor 1 receptor	Homo sapiens	99-105
26496208-6	2016	STAT1 regulates the transcriptional activity of OGG1 through recruiting and binding to the gamma-interferon activation site (GAS) motif of the OGG1 promoter region, and chromatin remodeling by acetylation and dimethylation of lysine-14 and -4 residues of histone H3.	Lysine	226-232	signal transducer and activator of transcription 1	Homo sapiens	0-5
26792178-8	2016	Ubiquitylomic analysis of mouse glomeruli revealed that podocin is ubiquitylated at two lysine residues.	Lysine	88-94	nephrosis 2, podocin	Mus musculus	56-63
27030801-6	2016	HMO1 has an unusual domain architecture compared to vertebrate HMGB proteins in that the HMG domains are followed by a lysine-rich extension instead of an acidic domain.	Lysine	119-125	Hmo1p	Saccharomyces cerevisiae S288C	0-4
26970896-6	2016	LSD1 inhibition increased histone H3 lysine 4 (H3K4) methylation, downregulated expression of several leukemia-relevant genes, induced apoptosis and differentiation, and inhibited self-renewal of stem-like leukemia cells.	Lysine	37-43	lysine demethylase 1A	Homo sapiens	0-4
26970896-7	2016	Moreover, LSD1 inhibitors worked synergistically with inhibition of DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, against MLL-rearranged leukemia.	Lysine	88-94	lysine demethylase 1A	Homo sapiens	10-14
26786097-11	2016	Proteasome inhibition led to accumulation of K48-linked ubiquitinated RIPK3, which was partially reduced when Lys-264 was mutated.	Lysine	110-113	receptor interacting serine/threonine kinase 3	Homo sapiens	70-75
26747610-4	2016	The Rpd3S histone deacetylase utilizes the chromodomain-containing Eaf3 subunit and the PHD domain-containing Rco1 subunit to recognize nucleosomes that are methylated at lysine 36 of histone H3 (H3K36me).	Lysine	171-177	mortality factor 4 like 1	Homo sapiens	67-71
26888970-9	2016	Restoring the expression of RAD51 and BRCA1 by treatment with EZH2 inhibitor was dependent on reducing the enrichment of trimethylation of histone 3 lysine 27 epigenetic mark in their promoter regions.	Lysine	149-155	RAD51 recombinase	Homo sapiens	28-33
26888970-9	2016	Restoring the expression of RAD51 and BRCA1 by treatment with EZH2 inhibitor was dependent on reducing the enrichment of trimethylation of histone 3 lysine 27 epigenetic mark in their promoter regions.	Lysine	149-155	BRCA1 DNA repair associated	Homo sapiens	38-43
27281850-1	2016	In the Saccharomyces cerevisiae yeasts, the DOT1 gene product provides methylation of lysine 79 (K79) of hi- stone H3 and the SET2 gene product provides the methylation of lysine 36 (K36) of the same histone.	Lysine	172-178	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	126-130
26896718-7	2016	Presence of lysine and arginine residues that have been previously reported to undergo nonenzymatic glycosylation in CBS1 and CBS2 suggests that cetirizine transport in patients with diabetes could be altered.	Lysine	12-18	methionine sulfoxide reductase B2	Homo sapiens	117-121
26757344-3	2016	While this modification was long considered to be irreversible, two different classes of enzymes capable of carrying out the demethylation of histone lysines were recently identified: the oxidases, such as LSD1, and the oxygenases (JmjC-containing).	Lysine	150-157	lysine demethylase 1A	Homo sapiens	206-210
26966660-11	2016	Our initial analysis revealed that another remarkable trait of San1 is shared with several candidate E3 ligases: long stretches of complete lysine suppression, which in San1 limits auto-ubiquitination.	Lysine	140-146	ubiquitin-protein ligase SAN1	Saccharomyces cerevisiae S288C	63-67
26966660-11	2016	Our initial analysis revealed that another remarkable trait of San1 is shared with several candidate E3 ligases: long stretches of complete lysine suppression, which in San1 limits auto-ubiquitination.	Lysine	140-146	ubiquitin-protein ligase SAN1	Saccharomyces cerevisiae S288C	169-173
26854234-3	2016	SIRT2 interacts with and deacetylates ATRIP at lysine 32 (K32) in response to replication stress.	Lysine	47-53	ATR interacting protein	Homo sapiens	38-43
26747897-2	2016	Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells in vitro and in vivo.	Lysine	36-42	lysine demethylase 5D	Homo sapiens	85-90
26747897-2	2016	Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells in vitro and in vivo.	Lysine	36-42	lysine demethylase 5D	Homo sapiens	95-99
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	66-72	KIT ligand	Homo sapiens	0-3
26774286-5	2016	SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.	Lysine	81-87	KIT ligand	Homo sapiens	0-3
26781951-5	2016	For lysine-reverse-labeled micro-crystalline GB1 protein, the 2D (15)N/(13)Calpha correlation and 2D (13)Calpha/(13)CO correlation SSNMR spectra by the HIGHLIGHT approach yielded signals only for six residues following and preceding the unlabeled lysine residues, respectively.	Lysine	4-10	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	45-48
26781951-5	2016	For lysine-reverse-labeled micro-crystalline GB1 protein, the 2D (15)N/(13)Calpha correlation and 2D (13)Calpha/(13)CO correlation SSNMR spectra by the HIGHLIGHT approach yielded signals only for six residues following and preceding the unlabeled lysine residues, respectively.	Lysine	247-253	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	45-48
26781951-8	2016	We also discuss how the HIGHLIGHT approach facilitates signal assignments using (13)C-detected 3D SSNMR by demonstrating full sequential assignments of lysine-reverse-labeled micro-crystalline GB1 protein (~300 nmol), for which data collection required only 11 h. The HIGHLIGHT approach offers valuable means of signal assignments especially for larger proteins through reducing the number of resonance and clarifying multiple starting points in sequential assignment with enhanced sensitivity.	Lysine	152-158	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	193-196
26590165-4	2016	EZH2 catalyzes methylation of lysine 27 on histone H3 and its deregulation in cancer has been reported to contribute to silencing of tumor suppressor genes, resulting in a more undifferentiated state, and thereby contributing to the multiple myeloma phenotype.	Lysine	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
26567139-5	2016	We found that PRC2 components and demethylase JMJD3-mediated histone H3 lysine 27 trimethylation (H3K27me3) repress the expression and subsequent production of Th1-type chemokines CXCL9 and CXCL10, mediators of effector T-cell trafficking.	Lysine	72-78	lysine demethylase 6B	Homo sapiens	46-51
26567139-5	2016	We found that PRC2 components and demethylase JMJD3-mediated histone H3 lysine 27 trimethylation (H3K27me3) repress the expression and subsequent production of Th1-type chemokines CXCL9 and CXCL10, mediators of effector T-cell trafficking.	Lysine	72-78	C-X-C motif chemokine ligand 10	Homo sapiens	190-196
26376067-5	2016	The lysine at the mutation position was highly conserved from Drosophila to humans and was recognized as a methylation location in the GATA4 protein.	Lysine	4-10	GATA binding protein 4	Homo sapiens	135-140
26748827-5	2016	MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes.	Lysine	96-102	MDM2 proto-oncogene	Homo sapiens	0-4
26748827-5	2016	MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes.	Lysine	146-152	MDM2 proto-oncogene	Homo sapiens	0-4
26255286-4	2016	Radiolabeling of wild-type annexin V with fluorine-18 ((18)F) can be accomplished via random acylation of 23 amine groups (22 lysine residues and one N-terminal amine) with [(18)F]SFB or site-specific alkylation reaction on cysteine residue at position 315 with maleimide-containing prosthetic groups like [(18)F]FBEM.	Lysine	126-132	annexin A5	Mus musculus	27-36
27096066-7	2016	At local site, mRNA and protein levels of lung-derived pro-inflammatory cytokines IL-33 and TSLP were markedly down-regulated following SLIT that was associated with marked enrichment of trimethylated lysine 27 of histone H3 at promoter regions of these two cytokines.	Lysine	201-207	interleukin 33	Mus musculus	82-87
26590302-3	2016	We have recently demonstrated that Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 is critical for Dnmt1 recruitment to DNA replication sites, which catalyzes the conversion of hemi-methylated DNA to fully methylated DNA.	Lysine	83-89	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	35-40
26590302-3	2016	We have recently demonstrated that Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 is critical for Dnmt1 recruitment to DNA replication sites, which catalyzes the conversion of hemi-methylated DNA to fully methylated DNA.	Lysine	83-89	DNA methyltransferase 1	Homo sapiens	109-114
28131285-0	2016	A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.	Lysine	11-14	androgen receptor	Mus musculus	74-91
26821844-3	2016	We found that mutation of H3 lysine 36 (H3K36) - a residue methylated by Set2 during transcription elongation - exhibited phenotypes similar to those of pre-mRNA splicing mutants.	Lysine	29-35	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	73-77
26694325-7	2015	VEGF-induced proliferation was reduced either by U-0126 or LY-294002.	Lysine	59-61	vascular endothelial growth factor A	Mus musculus	0-4
26577067-1	2015	JMJD2A catalyses the demethylation of di- and trimethylated lysine residues in histone tails and is a target for the development of new anticancer medicines.	Lysine	60-66	lysine demethylase 4A	Homo sapiens	0-6
26485572-1	2015	PEGylated polylysine peptides of the general structure PEG30 kDa-Cys-Trp-LysN (N = 10 to 30) were used to form fully condensed plasmid DNA (pGL3) polyplexes at a ratio of 1 nmol of peptide per mug of DNA (ranging from N:P 3:1 to 10:1 depending on Lys repeat).	Lysine	73-76	succinate dehydrogenase complex subunit C	Homo sapiens	140-144
26189760-4	2015	Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters.	Lysine	204-210	Sp7 transcription factor 7	Mus musculus	86-93
26189760-4	2015	Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters.	Lysine	204-210	Sp7 transcription factor 7	Mus musculus	95-98
26548852-4	2015	We also identified the 27th amino acid (lysine) of DOK3 is responsible for Ly48 polyubiquitination of DOK3.	Lysine	40-46	docking protein 3	Homo sapiens	51-55
26548852-4	2015	We also identified the 27th amino acid (lysine) of DOK3 is responsible for Ly48 polyubiquitination of DOK3.	Lysine	40-46	docking protein 3	Homo sapiens	102-106
26453305-0	2015	TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORgammat in Promoting IL-17A Expression.	Lysine	15-18	TNF receptor associated factor 5	Homo sapiens	0-5
26453305-0	2015	TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORgammat in Promoting IL-17A Expression.	Lysine	15-18	interleukin 17A	Homo sapiens	121-127
26453305-2	2015	In this study, we show that tumor necrosis factor receptor-associated factor 5 (TRAF5), known as an E3 ubiquitin protein ligase and signal transducer, interacts with and ubiquitinates RORgammat via Lys-63-linked polyubiquitination.	Lysine	198-201	TNF receptor associated factor 5	Homo sapiens	28-78
26453305-2	2015	In this study, we show that tumor necrosis factor receptor-associated factor 5 (TRAF5), known as an E3 ubiquitin protein ligase and signal transducer, interacts with and ubiquitinates RORgammat via Lys-63-linked polyubiquitination.	Lysine	198-201	TNF receptor associated factor 5	Homo sapiens	80-85
26446255-5	2015	Ubiquitylation of cytoplasmic lysine residues was required for the extraction of CD8(TMD*) from the ER membrane during ERAD, whereas CD8(LUM*) continued to be degraded in the absence of cytoplasmic lysine residues.	Lysine	30-36	CD8a molecule	Homo sapiens	81-84
26446255-6	2015	Cytoplasmic lysine residues were also required for degradation of an additional ERAD substrate containing an unassembled transmembrane domain and when a non-native transmembrane domain was introduced into CD8(LUM*).	Lysine	12-18	CD8a molecule	Homo sapiens	205-208
26558777-10	2015	These findings indicate that disrupting the interaction between BET proteins and their acetylated lysine substrates may provide a new therapeutic avenue for the treatment of drug addiction.	Lysine	98-104	delta/notch-like EGF repeat containing	Mus musculus	64-67
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	delta/notch-like EGF repeat containing	Mus musculus	103-106
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	bromodomain containing 4	Rattus norvegicus	151-155
26558777-11	2015	SIGNIFICANCE STATEMENT: Proteins involved in the "readout" of lysine acetylation marks, referred to as BET bromodomain proteins (including BRD2, BRD3, BRD4, and BRDT), have been shown to be key regulators of chromatin dynamics and disease, and BET inhibitors are currently being studied in several clinical trials.	Lysine	62-68	delta/notch-like EGF repeat containing	Mus musculus	244-247
26551560-2	2015	Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with redistribution of enhancer of zeste homolog 2 (EZH2)-dependent histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	192-198	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	136-163
26551560-2	2015	Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with redistribution of enhancer of zeste homolog 2 (EZH2)-dependent histone H3 lysine 27 trimethylation (H3K27me3).	Lysine	192-198	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	165-169
26334932-2	2015	Among the identified histone methyltransferases (HMTases), G9a is a histone H3 Lys 9 (H3K9)-specific example active in euchromatic regions.	Lysine	79-82	G9a	Drosophila melanogaster	59-62
26338712-2	2015	Widely interspaced zinc finger (WIZ) associates with the G9a-GLP protein complex, but its role in mediating lysine methylation is poorly defined.	Lysine	108-114	euchromatic histone lysine methyltransferase 2	Homo sapiens	57-60
26298709-4	2015	The histone modification effect of DZNep on the lysine 9 of histone 3 associated with MOB1 promoters was examined with chromatin immunoprecipitation and quantitative PCR, and CpG methylation in MOB1 promoters was detected by bisulfite sequencing PCR.	Lysine	48-54	MOB kinase activator 1A	Homo sapiens	86-90
26018935-2	2015	Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling.	Lysine	55-62	linker for activation of T cells	Mus musculus	51-54
26018935-2	2015	Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling.	Lysine	55-62	linker for activation of T cells	Mus musculus	83-86
26722485-1	2015	KDM4A, KDM4B and KDM4D are lysine demethylases which demethylate H3 at lysine K9 and K36 sites, additionally KDM4D also the H1.4 linker histone at K26 lysine.	Lysine	27-33	lysine demethylase 4A	Homo sapiens	0-5
26722485-1	2015	KDM4A, KDM4B and KDM4D are lysine demethylases which demethylate H3 at lysine K9 and K36 sites, additionally KDM4D also the H1.4 linker histone at K26 lysine.	Lysine	27-33	H1.4 linker histone, cluster member	Homo sapiens	124-128
26344097-1	2015	BRCC36 is a Zn(2+)-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition.	Lysine	75-81	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	0-6
26321253-5	2015	Further, SUMO-RanGAP1 bound to the N-terminal lysine 56 of SLP-76 where the interaction was needed for optimal RanGAP1-NPC localization and GAP exchange activity.	Lysine	46-52	lymphocyte cytosolic protein 2	Homo sapiens	59-65
26291311-2	2015	Here, we demonstrate that SOX4 acetylation at lysine 95 by KAT5 (also known as Tip60) is essential for Cald1 promoter activity at the onset of C2C12 myoblast differentiation.	Lysine	46-52	SRY-box transcription factor 4	Homo sapiens	26-30
26291311-2	2015	Here, we demonstrate that SOX4 acetylation at lysine 95 by KAT5 (also known as Tip60) is essential for Cald1 promoter activity at the onset of C2C12 myoblast differentiation.	Lysine	46-52	lysine acetyltransferase 5	Homo sapiens	59-63
26291311-2	2015	Here, we demonstrate that SOX4 acetylation at lysine 95 by KAT5 (also known as Tip60) is essential for Cald1 promoter activity at the onset of C2C12 myoblast differentiation.	Lysine	46-52	lysine acetyltransferase 5	Homo sapiens	79-84
26116533-2	2015	In agreement with a previous study, we validate Ubc9 to facilitate SUMOylation of hRXRalpha at lysine 108 but note this modification to occur for all isoforms rather than specifically with SUMO1 and to preferentially occur with the unliganded form of hRXRalpha.	Lysine	95-101	retinoid X receptor alpha	Homo sapiens	82-91
26116533-3	2015	SUMOylation of hRXRalpha is significantly enhanced through PIAS4-mediated activity with lysine 245 identified as a specific SUMO2 acceptor site modified in a PIAS4-dependent fashion.	Lysine	88-94	retinoid X receptor alpha	Homo sapiens	15-24
26116533-3	2015	SUMOylation of hRXRalpha is significantly enhanced through PIAS4-mediated activity with lysine 245 identified as a specific SUMO2 acceptor site modified in a PIAS4-dependent fashion.	Lysine	88-94	protein inhibitor of activated STAT 4	Homo sapiens	59-64
26116533-3	2015	SUMOylation of hRXRalpha is significantly enhanced through PIAS4-mediated activity with lysine 245 identified as a specific SUMO2 acceptor site modified in a PIAS4-dependent fashion.	Lysine	88-94	protein inhibitor of activated STAT 4	Homo sapiens	158-163
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	98-103
26267652-6	2015	Enrichment of histone-3 lysine-4 trimethylation (H3K4me3) changed significantly at genes Cyp4a14, Gapdh, Nr3c1, Pck1, Ppara, and Sqle.	Lysine	24-30	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	112-116
26205499-7	2015	At the molecular level, Lys(61) of PAQR3 is targeted by DDB2 for ubiquitination.	Lysine	24-27	progestin and adipoQ receptor family member 3	Homo sapiens	35-40
26002909-5	2015	Notably, GCN5-mediated acetylation of histone 3 lysine 9 and histone 3 lysine 14 of FERRIC REDUCTASE DEFECTIVE3 (FRD3) determined the dynamic expression of FRD3.	Lysine	48-54	general control non-repressible 5	Arabidopsis thaliana	9-13
26271983-1	2015	OBJECTIVE: To understand which lysine (K) residue in ubiquitin (Ub) is used to form a poly-Ubs chain on discoidin domain receptor 2 (DDR2).	Lysine	31-37	discoidin domain receptor tyrosine kinase 2	Homo sapiens	104-131
26271983-1	2015	OBJECTIVE: To understand which lysine (K) residue in ubiquitin (Ub) is used to form a poly-Ubs chain on discoidin domain receptor 2 (DDR2).	Lysine	31-37	discoidin domain receptor tyrosine kinase 2	Homo sapiens	133-137
26225565-3	2015	MAML1 also contains numerous lysine residues that may also be ubiquitinated and necessary for protein regulation.	Lysine	29-35	mastermind like transcriptional coactivator 1	Homo sapiens	0-5
26225565-4	2015	In this study, we show that over-expressed MAML1 is ubiquitinated and identify eight conserved lysine residues which are required for ubiquitination.	Lysine	95-101	mastermind like transcriptional coactivator 1	Homo sapiens	43-48
26175007-4	2015	Moreover, selective arginylation of PRPS2 but not PRPS1 is regulated through a coding sequence-dependent mechanism that combines elements of mRNA secondary structure with lysine residues encoded near the N-terminus of PRPS1.	Lysine	171-177	phosphoribosyl pyrophosphate synthetase 2	Homo sapiens	36-41
25999347-3	2015	In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1 to the site of DNA damage promotes local H3K4me2 demethylation and ubiquitination of H2A/H2AX, facilitating 53BP1 recruitment to sites of DNA damage.	Lysine	63-69	lysine demethylase 1A	Homo sapiens	91-95
25545350-5	2015	Here, we show that lysine-specific histone demethylase1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic genes Cyp7a1 and Cyp8b1 and the BA uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-4, leading to gene repression.	Lysine	19-25	lysine demethylase 1A	Homo sapiens	57-61
25545350-6	2015	Recruitment of LSD1 was dependent on small heterodimer partner, and LSD1-mediated demethylation of trimethylated histone H3 lysine-4 was required for additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.	Lysine	124-130	lysine demethylase 1A	Homo sapiens	68-72
25545350-6	2015	Recruitment of LSD1 was dependent on small heterodimer partner, and LSD1-mediated demethylation of trimethylated histone H3 lysine-4 was required for additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.	Lysine	219-225	lysine demethylase 1A	Homo sapiens	15-19
25545350-6	2015	Recruitment of LSD1 was dependent on small heterodimer partner, and LSD1-mediated demethylation of trimethylated histone H3 lysine-4 was required for additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.	Lysine	219-225	lysine demethylase 1A	Homo sapiens	68-72
25545350-6	2015	Recruitment of LSD1 was dependent on small heterodimer partner, and LSD1-mediated demethylation of trimethylated histone H3 lysine-4 was required for additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.	Lysine	219-225	lysine demethylase 1A	Homo sapiens	15-19
25545350-6	2015	Recruitment of LSD1 was dependent on small heterodimer partner, and LSD1-mediated demethylation of trimethylated histone H3 lysine-4 was required for additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.	Lysine	219-225	lysine demethylase 1A	Homo sapiens	68-72
25998860-7	2015	The histone demethylase JMJD3 opposes the activity of EZH2 by demethylating histone H3 lysine 27.	Lysine	87-93	lysine demethylase 6B	Homo sapiens	24-29
26115014-1	2015	The opaque-2 (o2) mutation of maize increases lysine content, but the low seed density and soft texture of this type of mutant are undesirable.	Lysine	46-52	regulatory protein opaque-2	Zea mays	4-12
25934393-10	2015	Using unnatural amino acid incorporation, we demonstrate the requirement for a planar amino acid at Kir6.2 position 68 for normal channel gating, which is potentially necessary to localize the epsilon-amine of Lys-170 in the phosphatidylinositol 4,5-bisphosphate-binding site.	Lysine	210-213	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	100-106
26046535-6	2015	Multiple gamma-secretase inhibitors (GSIs) and (Z-LL)2 ketone differentially inhibited SPP/SPPL activity; for example, IC50 of LY-411,575 varied from 51+-79 nM (on SPPL2a) to 5499+-122 nM (on SPPL2b), while Compound E showed inhibition only on hSPP with IC50 of 1465+-93 nM.	Lysine	127-129	signal peptide peptidase like 2B	Homo sapiens	192-198
25346381-1	2015	Lysine-specific demethylase 1 (LSD1) plays an important role in regulating the lysine methylation at residues K4 and K9 on histone H3.	Lysine	79-85	lysine demethylase 1A	Homo sapiens	0-29
25346381-1	2015	Lysine-specific demethylase 1 (LSD1) plays an important role in regulating the lysine methylation at residues K4 and K9 on histone H3.	Lysine	79-85	lysine demethylase 1A	Homo sapiens	31-35
25888615-0	2015	Lysine Residues Are Not Required for Proteasome-Mediated Proteolysis of the Auxin/Indole Acidic Acid Protein IAA1.	Lysine	0-6	indole-3-acetic acid inducible	Arabidopsis thaliana	109-113
25888615-7	2015	Lys-substituted versions of IAA1 localized to the nucleus as Yellow Fluorescent Protein fusions and interacted with both TIR1 and IAA7 in yeast (Saccharomyces cerevisiae) two-hybrid experiments, indicating that these proteins were functional.	Lysine	0-3	indole-3-acetic acid inducible	Arabidopsis thaliana	28-32
25888615-8	2015	Ubiquitination on both HIS(6x)-HA(3x)-IAA1 and Lys-less HIS(6x)-HA(3x)-IAA1 proteins was sensitive to sodium hydroxide treatment, indicative of ubiquitin oxyester formation on serine or threonine residues.	Lysine	47-50	indole-3-acetic acid inducible	Arabidopsis thaliana	71-75
25752909-12	2015	Notably, the pyranosyl moiety of dTDP-Qui4N is positioned into the active site by only one hydrogen bond provided by Lys 77.	Lysine	117-120	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	33-37
26010904-7	2015	The only conserved lysine identified as ubiquitinated in one but not the other heat shock protein was K159 in Hsc70.	Lysine	19-25	heat shock protein family A (Hsp70) member 8	Homo sapiens	110-115
25978433-2	2015	Methylation of lysine 9 on histone H3 by the methyltransferase G9a and SUV39H1 is associated with inhibition of tumor suppressor genes.	Lysine	15-21	euchromatic histone lysine methyltransferase 2	Homo sapiens	63-66
25955299-8	2015	Moreover, the antibody-mediated blockade of CD82 in leukemia cells lowered EZH2 expression via activation of p38 MAPK signaling, decreased the amount of EZH2 bound to the promoter regions of the tumor suppressor genes, and inhibited histone H3 lysine 27 trimethylation in these promoter regions, resulting in upregulation of the tumor suppressors at both the mRNA and protein levels.	Lysine	244-250	CD82 molecule	Homo sapiens	44-48
25948511-1	2015	Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates beta-adrenergic-induced systemic metabolism and body weight control.	Lysine	10-16	lysine demethylase 3A	Homo sapiens	38-44
25755297-7	2015	A site-specific approach was used to map over 1000 SUMO-2 acceptor lysines in target proteins.	Lysine	67-74	small ubiquitin like modifier 2	Homo sapiens	51-57
25907794-4	2015	Here, we generate milligram quantities of pure human Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal protection with activated ligation (GOPAL), to investigate their effect on DIX polymerization.	Lysine	95-102	dishevelled segment polarity protein 2	Homo sapiens	53-57
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	CYLD lysine 63 deubiquitinase	Homo sapiens	0-4
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	TNF receptor associated factor 2	Homo sapiens	217-267
24909169-1	2015	CYLD is a deubiquitinating (DUB) enzyme that has a pivotal role in modulating nuclear factor kappa B (NF-kappaB) signaling pathways by removing the lysine 63- and linear-linked ubiquitin chain from substrates such as tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF6.	Lysine	148-154	TNF receptor associated factor 2	Homo sapiens	269-274
25755250-4	2015	We have identified that acetylation occurs at three lysine residues, K159, K185, and K404 (3K), and enhances the association between GOT2 and MDH2.	Lysine	52-58	malate dehydrogenase 2	Homo sapiens	142-146
25716317-6	2015	Here, we demonstrated that the TRAF2-TRIP interaction inhibits Lys(63)-linked TRAF2 ubiquitination by inhibiting TRAF2 E3 ubiquitin (Ub) ligase activity.	Lysine	63-66	TNF receptor associated factor 2	Homo sapiens	31-36
25716317-6	2015	Here, we demonstrated that the TRAF2-TRIP interaction inhibits Lys(63)-linked TRAF2 ubiquitination by inhibiting TRAF2 E3 ubiquitin (Ub) ligase activity.	Lysine	63-66	TNF receptor associated factor 2	Homo sapiens	78-83
25716317-6	2015	Here, we demonstrated that the TRAF2-TRIP interaction inhibits Lys(63)-linked TRAF2 ubiquitination by inhibiting TRAF2 E3 ubiquitin (Ub) ligase activity.	Lysine	63-66	TNF receptor associated factor 2	Homo sapiens	78-83
25855960-3	2015	Here, we show that PCAF can directly acetylate cytoplasmic GLI1 protein at lysine 518, preventing its nuclear translocation and promoter occupancy, and consequently suppressing Hedgehog (Hh) signaling in HCC.	Lysine	75-81	GLI family zinc finger 1	Homo sapiens	59-63
25660450-4	2015	Interestingly, we found that MPP8 physically interacts with PRC1 (Polycomb Repressive Complex 1) components which are known to possess essential function in testis development by modulating monoubiquitination of Histone H2A (uH2A) and trimethylation of Histone H3 Lysine 27 (H3K27me3) residues.	Lysine	264-270	M-phase phosphoprotein 8	Homo sapiens	29-33
25867302-10	2015	Thus, the dietary Leu:Lys ratio affects the expression of genes coding for amino acid transporters and myosin, the availability of Lys, and the growth rate and efficiency in pigs.	Lysine	22-25	myosin X	Sus scrofa	103-109
25636230-2	2015	We optimized the method of identification of lysine residues prone to glycation using the combination of LC-MS, isotopic labeling, and modified synthetic peptide standards with the glycated lysine derivative (Fmoc-Lys(i,i-Fru,Boc)-OH).	Lysine	45-51	BOC cell adhesion associated, oncogene regulated	Homo sapiens	226-229
25759518-2	2015	We have established a simple method to measure LSD1 activity using a synthetic N-terminal 21-mer peptide of histone H3, which is dimethylated at Lys-4 (H3K4me2).	Lysine	145-148	lysine demethylase 1A	Homo sapiens	47-51
25628362-3	2015	Lys20 was initially described as homocitrate synthase (HCS), the first enzyme in the lysine biosynthetic pathway in yeast.	Lysine	85-91	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	0-5
25607844-4	2015	To accomplish this, we bypassed the inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutating conserved lysines in the polyQ AR that are sites of SUMOylation.	Lysine	147-154	androgen receptor	Mus musculus	168-170
25134795-1	2015	Eed (embryonic ectoderm development) is a core component of the Polycomb Repressive Complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27).	Lysine	147-153	embryonic ectoderm development	Homo sapiens	0-3
25134795-1	2015	Eed (embryonic ectoderm development) is a core component of the Polycomb Repressive Complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27).	Lysine	147-153	embryonic ectoderm development	Homo sapiens	5-35
25391650-0	2015	Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9.	Lysine	37-43	mediator complex subunit 25	Homo sapiens	65-70
25425640-2	2015	Bovine beta-arrestin 2 has been shown to be SUMOylated on the lysine 400 residue, which links it to the endocytosis of the beta2-adrenergic receptor.	Lysine	62-68	adrenoceptor beta 2	Bos taurus	123-148
25596733-1	2015	Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood.	Lysine	45-51	lysine (K)-specific demethylase 5B	Mus musculus	192-199
25395428-1	2015	Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27).	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
25395428-1	2015	Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27).	Lysine	132-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
25416781-6	2015	Furthermore, METTL20 was found to specifically methylate two adjacent lysine residues, Lys(200) and Lys(203), in ETFbeta both in vitro and in cells.	Lysine	70-76	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	13-20
25416781-6	2015	Furthermore, METTL20 was found to specifically methylate two adjacent lysine residues, Lys(200) and Lys(203), in ETFbeta both in vitro and in cells.	Lysine	87-90	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	13-20
25416781-6	2015	Furthermore, METTL20 was found to specifically methylate two adjacent lysine residues, Lys(200) and Lys(203), in ETFbeta both in vitro and in cells.	Lysine	100-103	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	13-20
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Lysine	26-29	F11 receptor	Homo sapiens	87-91
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Lysine	26-29	F11 receptor	Homo sapiens	134-139
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Lysine	35-38	F11 receptor	Homo sapiens	87-91
28509452-4	2015	We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.	Lysine	35-38	F11 receptor	Homo sapiens	134-139
25746101-4	2015	Histone acetyl transferase (HAT) is referred to as the writer of this process, whereas histone deacetylase (HDAC) is the eraser of this lysine modification.	Lysine	136-142	histone deacetylase 9	Homo sapiens	87-106
25746101-4	2015	Histone acetyl transferase (HAT) is referred to as the writer of this process, whereas histone deacetylase (HDAC) is the eraser of this lysine modification.	Lysine	136-142	histone deacetylase 9	Homo sapiens	108-112
26159193-0	2015	Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer"s Mice and in Human Patients.	Lysine	39-45	LOC102641229	Mus musculus	25-35
26159193-4	2015	The aim of the present study was to examine acetylation of histone H4 at lysine 12 (H4K12) in monocytes in two transgenic AD mouse models (the triple transgenic 3xTg and a model overexpressing amyloid-precursor protein APP with the Swedish-Dutch-Iowa mutations), and to compare with monocytes isolated from human patients with mild cognitive impairment (MCI) and AD.	Lysine	73-79	LOC102641229	Mus musculus	59-69
25923537-2	2015	The Tudor domains of human homologs PHF1 and PHF19 have been found to recognize trimethylated lysine 36 of histone H3 (H3K36me3); however, the biological role of Tudor domains of other Pcl proteins remains poorly understood.	Lysine	94-100	PHD finger protein 1	Homo sapiens	36-40
26230878-1	2015	BACKGROUND: LSD-1 is an enzyme that removes methyl groups from lysine residues of histone proteins.	Lysine	63-69	lysine demethylase 1A	Homo sapiens	12-17
25897479-2	2015	The mutation results in substitution of a termination codon (TAA) for lysine (AAG) at amino acid position 56.	Lysine	70-76	N-methylpurine DNA glycosylase	Homo sapiens	78-81
25353373-0	2015	Cks1 proteasomal turnover is a predominant mode of regulation in breast cancer cells: role of key tyrosines and lysines.	Lysine	112-119	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	0-4
25353373-12	2015	Taken together, regulation of Cks1 protein stability is crucially dependent on specific tyrosine and lysine residues which are potential sites for post-translational modifications.	Lysine	101-107	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	30-34
25380826-4	2015	PHD3 SUMOylation occurs at a cluster of four lysines at the C-terminal end of the protein.	Lysine	45-52	egl-9 family hypoxia inducible factor 3	Homo sapiens	0-4
25349251-5	2015	Mass spectrometric analysis revealed that both acyl and desacyl ghrelin were hydrolyzed at the peptide bond between Arg(15) and Lys(16), generating an N-terminal peptide consisting of the first 15 residues.	Lysine	128-131	ghrelin and obestatin prepropeptide	Bos taurus	64-71
25452565-9	2015	Decreased SIRT1 expression was associated with constitutively enhanced expression of the transcriptionally active form of the p65 (acetylated on lysine 310) subunit of NF-kappaB exclusively in the LPL compartment.	Lysine	145-151	sirtuin 1	Homo sapiens	10-15
25452565-12	2015	Our results point to a possible mechanism where the normal immunosuppressive function of SIRT1 is inhibited by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).	Lysine	195-201	sirtuin 1	Homo sapiens	89-94
26364657-1	2015	Lysine-specific demethylase (LSD1) is an important enzyme for histone lysine methylation.	Lysine	70-76	lysine demethylase 1A	Homo sapiens	29-33
25189741-2	2015	The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription.	Lysine	66-72	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	4-30
25189741-2	2015	The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses gene transcription.	Lysine	66-72	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	32-36
25815376-1	2015	SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues.	Lysine	100-106	sirtuin 1	Homo sapiens	0-5
25236159-0	2015	Mapping QTLs for opaque2 modifiers influencing the tryptophan content in quality protein maize using genomic and candidate gene-based SSRs of lysine and tryptophan metabolic pathway.	Lysine	142-148	regulatory protein opaque-2	Zea mays	17-24
25236159-2	2015	Quality protein maize (QPM) was developed by selecting genetic modifiers that convert opaque2 mutant containing high lysine and tryptophan.	Lysine	117-123	regulatory protein opaque-2	Zea mays	86-93
25035152-8	2015	Post-translational histone methylation at different histone 3 lysine residues was also observed to control the expression of genes related to AH as lysine-specific demethylase-1(LSD1), HSD11B2, and epithelial sodium channel subunit alpha (SCNN1A).	Lysine	62-68	lysine demethylase 1A	Homo sapiens	148-182
25628922-2	2015	KDM5B (also known as JARID1B) is a newly identified histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 4 on histone H3.	Lysine	173-179	lysine (K)-specific demethylase 5B	Mus musculus	0-5
25628922-2	2015	KDM5B (also known as JARID1B) is a newly identified histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 4 on histone H3.	Lysine	173-179	lysine (K)-specific demethylase 5B	Mus musculus	21-28
25482560-1	2014	Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.	Lysine	122-128	lysine demethylase 1A	Homo sapiens	0-29
25482560-1	2014	Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.	Lysine	122-128	lysine demethylase 1A	Homo sapiens	31-35
25482560-1	2014	Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.	Lysine	122-128	lysine demethylase 1A	Homo sapiens	37-42
25501223-1	2014	As a core member of polycomb repressive complex 2, the transcription and enzyme activity of enhancer of zeste homolog 2 (Ezh2) is directly involved in the trimethylation of lysine 27 on histone H3.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	92-119
25501223-1	2014	As a core member of polycomb repressive complex 2, the transcription and enzyme activity of enhancer of zeste homolog 2 (Ezh2) is directly involved in the trimethylation of lysine 27 on histone H3.	Lysine	173-179	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	121-125
25152374-3	2014	Building on the previously observed interaction between SIPL1 and PTEN, we report here that SIPL1 promotes PTEN polyubiquitination via lysine 48 (K48)-independent polyubiquitin chains.	Lysine	135-141	SHANK associated RH domain interactor	Homo sapiens	92-97
25184342-4	2014	The lysine auxotroph (lys1 ) exhibited a significant decrease in growth compared with that of BY4743 upon exposure to LoaOOH, albeit with the sufficient provision of lysine in the medium.	Lysine	166-172	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	22-26
25130261-5	2014	METHODS: Boc-protected lysine, the tetrapeptide Boc-Gly-Phe-Gly-Lys-OH, bovine serum albumin (BSA) and porcine gelatin were used as more complex models to determine the reactivity of the mentioned UV filters towards skin proteins under thermal or UV irradiation conditions.	Lysine	23-29	BOC cell adhesion associated, oncogene regulated	Homo sapiens	9-12
25336644-2	2014	Upon the loss of mitochondrial membrane potential (DeltaPsim), Lys-63-linked polyubiquitin chains accumulate on the mitochondrial outer membrane in a Parkin-dependent manner.	Lysine	63-66	Ubiquitin-63E	Drosophila melanogaster	77-90
25336644-6	2014	Our data indicate that the formation of Lys-63-linked polyubiquitin chains on depolarized mitochondria is not a key factor for the PINK1-Parkin pathway as was once thought.	Lysine	40-43	Ubiquitin-63E	Drosophila melanogaster	54-67
25200183-5	2014	These wide-ranging effects of SIRT7 on mitochondrial homeostasis are the consequence of the deacetylation of distinct lysine residues located in the hetero- and homodimerization domains of GABPbeta1, a master regulator of nuclear-encoded mitochondrial genes.	Lysine	118-124	sirtuin 7	Homo sapiens	30-35
25369635-5	2014	We found that Sirt1, Sirt2, and Sirt3 can catalyze the hydrolysis of lysine crotonylated histone peptides and proteins.	Lysine	69-75	sirtuin 1	Homo sapiens	14-19
25208472-5	2014	This interaction facilitated Beclin-1 ubiquitination through lysine 48 linkage, resulting in proteasome-mediated degradation, consequently maintaining a certain constitutive level of Beclin-1.	Lysine	61-67	beclin 1	Homo sapiens	29-37
25208472-5	2014	This interaction facilitated Beclin-1 ubiquitination through lysine 48 linkage, resulting in proteasome-mediated degradation, consequently maintaining a certain constitutive level of Beclin-1.	Lysine	61-67	beclin 1	Homo sapiens	183-191
25225294-5	2014	Moreover, in CHIP knockdown cells, IRE1 phosphorylation and the IRE1-TRAF2 interaction were nearly abolished under ER stress, which may be due to lacking ubiquitination of IRE1 on Lys(545) and Lys(828), respectively.	Lysine	180-183	TNF receptor associated factor 2	Homo sapiens	69-74
25225294-5	2014	Moreover, in CHIP knockdown cells, IRE1 phosphorylation and the IRE1-TRAF2 interaction were nearly abolished under ER stress, which may be due to lacking ubiquitination of IRE1 on Lys(545) and Lys(828), respectively.	Lysine	193-196	TNF receptor associated factor 2	Homo sapiens	69-74
25310986-1	2014	Histone H3 Lys 4 methylation (H3K4me) is deposited by the conserved SET1/MLL methyltransferases acting in multiprotein complexes, including Ash2 and Wdr5.	Lysine	11-14	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	68-72
25172512-3	2014	We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.	Lysine	94-101	tripeptidyl peptidase 1	Homo sapiens	27-31
25172512-3	2014	We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.	Lysine	94-101	ubiquitin specific peptidase 7	Homo sapiens	36-40
25172512-3	2014	We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.	Lysine	94-101	tripeptidyl peptidase 1	Homo sapiens	109-113
25172512-3	2014	We identify amino acids in TPP1 and USP7 that are critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.	Lysine	94-101	ubiquitin specific peptidase 7	Homo sapiens	166-170
24910389-5	2014	Mechanistically, p14(ARF) stabilizes SLUG through increased sumoylation at lysine residue 192.	Lysine	75-81	snail family transcriptional repressor 2	Homo sapiens	37-41
24847004-1	2014	Dienoyl-CoA reductase (DECR) deficiency with hyperlysinemia is a rare disorder affecting the metabolism of polyunsaturated fatty acids and lysine.	Lysine	50-56	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-21
24847004-1	2014	Dienoyl-CoA reductase (DECR) deficiency with hyperlysinemia is a rare disorder affecting the metabolism of polyunsaturated fatty acids and lysine.	Lysine	50-56	2,4-dienoyl-CoA reductase 1	Homo sapiens	23-27
24847004-6	2014	DECR and also the first step in lysine degradation are performed by NADP-dependent oxidoreductases explaining their in vivo deficiency.	Lysine	32-38	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-4
25176653-2	2014	Here, we show that JMJD3, a histone H3 lysine 27 (H3K27) demethylase, acts as a critical activator of neurogenesis from adult subventricular zone (SVZ) NSCs.	Lysine	39-45	lysine demethylase 6B	Homo sapiens	19-24
25181347-7	2014	Consistently, a significant reduction of lysine-specific demethylase KDM2A could be found after eight weeks of TAC at the Atp2a2 promoter.	Lysine	41-47	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	122-128
24821015-6	2014	Mutational analysis of the lysine residues in the Hxt1 N-terminal domain demonstrates that the two lysine residues, K12 and K39, serve as the putative ubiquitin-acceptor sites by the Rsp5 ubiquitin ligase.	Lysine	27-33	hexose transporter HXT1	Saccharomyces cerevisiae S288C	50-54
24821015-6	2014	Mutational analysis of the lysine residues in the Hxt1 N-terminal domain demonstrates that the two lysine residues, K12 and K39, serve as the putative ubiquitin-acceptor sites by the Rsp5 ubiquitin ligase.	Lysine	99-105	hexose transporter HXT1	Saccharomyces cerevisiae S288C	50-54
25023281-0	2014	Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.	Lysine	25-31	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	6-13
25023281-7	2014	Tagged METTL20 expressed in HEK293T cells specifically associates with the ETF and promotes the trimethylation of ETFbeta lysine residues 199 and 202.	Lysine	122-128	electron transfer flavoprotein subunit beta lysine methyltransferase	Homo sapiens	7-14
25044612-2	2014	The reversible covalent attachment of glutaraldehyde to lysine residues of GOX, CAT, and bovine serum albumin (BSA) led to the formation and functionalization of the self-healing protein hydrogel system.	Lysine	56-62	hydroxyacid oxidase 1	Homo sapiens	75-78
25144183-4	2014	By using ProSeAM as a chemical probe for lysine methylation, we identified substrates for two seven-beta-strand KMTs, METTL21A and METTL10, on a proteomic scale in mammalian cells.	Lysine	41-47	EEF1A lysine methyltransferase 2	Homo sapiens	131-138
25144183-9	2014	Subsequent biochemical characterization revealed that METTL10 specifically trimethylates EF1A1 at lysine 318 and that siRNA-mediated knockdown of METTL10 decreases EF1A1 methylation levels in vivo.	Lysine	98-104	EEF1A lysine methyltransferase 2	Homo sapiens	54-61
25092319-4	2014	UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238 in an IR-stimulated manner, which decreases ATMIN interaction with ATM and promotes MRN-mediated signaling.	Lysine	67-73	ATM interactor	Homo sapiens	20-25
25092319-4	2014	UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238 in an IR-stimulated manner, which decreases ATMIN interaction with ATM and promotes MRN-mediated signaling.	Lysine	67-73	ATM interactor	Homo sapiens	58-63
25092319-4	2014	UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238 in an IR-stimulated manner, which decreases ATMIN interaction with ATM and promotes MRN-mediated signaling.	Lysine	67-73	ATM interactor	Homo sapiens	58-63
25092319-5	2014	We show that UBR5 deficiency, or mutation of ATMIN lysine 238, prevents ATMIN dissociation from ATM and inhibits ATM and NBS1 foci formation after IR, thereby impairing checkpoint activation and increasing radiosensitivity.	Lysine	51-57	ATM interactor	Homo sapiens	45-50
25092319-5	2014	We show that UBR5 deficiency, or mutation of ATMIN lysine 238, prevents ATMIN dissociation from ATM and inhibits ATM and NBS1 foci formation after IR, thereby impairing checkpoint activation and increasing radiosensitivity.	Lysine	51-57	ATM interactor	Homo sapiens	72-77
24721162-1	2014	Acetylation-dependent inactivation of STAT1 can be mimicked by the exchange of its lysine residues K410 and K413 to glutamine residues.	Lysine	83-89	signal transducer and activator of transcription 1	Homo sapiens	38-43
24721162-12	2014	This molecule mimics corresponding lysine residues found within the DBD of STAT1.	Lysine	35-41	signal transducer and activator of transcription 1	Homo sapiens	75-80
24917417-5	2014	Microbial transglutaminase (mTG) or chymotrypsin (ChT) was used to bind lysine or valine to gluten proteins in a model system.	Lysine	72-78	protease, serine 3	Mus musculus	28-31
25016215-9	2014	In addition, loss of dKDM2 appears to have rather weak effects on histone H3 lysine 36 and 4 methylation (H3K36me and H3K4me) in the third instar wandering larvae, and we observed no effect on methylation of H3K9me2, H3K27me2 and H3K27me3 in dKdm2 mutants.	Lysine	77-83	Lysine (K)-specific demethylase 2	Drosophila melanogaster	21-26
24831241-3	2014	We find that accessory (Lys -3, Trp -2, Ser -1 and Leu +2) and canonical (D -4, Leu 0 and Leu +1) residues confer the DKWSLLL signal with the versatility required for the Cu(+)-regulated cycling of ATP7B between the trans-Golgi network (TGN) and the plasma membrane (PM).	Lysine	24-27	ATPase copper transporting beta	Homo sapiens	198-203
25061856-2	2014	The recruitment of Polycomb complexes to specific targets has been widely thought to occur in two steps: first, one complex, PRC2, produces histone H3 lysine 27 (H3K27) trimethylation at a specific gene, and then the PRC1 complex is recruited by its ability to bind to H3K27me3.	Lysine	151-157	chromobox 2	Mus musculus	19-27
25056273-4	2014	Here we report that the lysine residue in the PP1-binding motif of BRCA1 is highly conserved across many mammalian species.	Lysine	24-30	BRCA1 DNA repair associated	Homo sapiens	67-72
25023514-3	2014	dsirt2 mutant flies displayed increased acetylation of specific Lys residues in ATP synthase beta and decreased complex V activity.	Lysine	64-67	ATP synthase, subunit B	Drosophila melanogaster	80-97
24879532-2	2014	The orthogonally Boc/Alloc protected DKP precursors prepared from L-lysine residues and an aminohexyl arm are efficiently prepared on a gram scale by sequentially using Fukuyama-Mitsunobu alkylation, dipeptide coupling and diketopiperazine ring formation as key steps.	Lysine	66-74	BOC cell adhesion associated, oncogene regulated	Homo sapiens	17-20
25010489-5	2014	BPTI variants carrying Arg, Lys, Ile, Leu or Ala at the P2" position of the binding loop were purified and equilibrium dissociation constants were determined against non-sulfated and sulfated cationic and anionic human trypsins.	Lysine	28-31	spleen trypsin inhibitor I	Bos taurus	0-4
24794925-4	2014	Here we use genetic tools and chemical inhibitors to modify the epigenetic program of hASCs and identify lysine-specific demethylase 1 (LSD1), a histone demethylase that specifically catalyzes demethylation of di- and mono- methyl histone H3 lysine 4 (H3K4me2/1), as a key regulator in osteogenic differentiation of hASCs.	Lysine	105-111	lysine demethylase 1A	Homo sapiens	136-140
24979794-1	2014	The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription.	Lysine	86-93	delta/notch-like EGF repeat containing	Mus musculus	35-38
24715612-0	2014	Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate.	Lysine	33-39	lysine demethylase 1A	Homo sapiens	61-65
24798337-2	2014	KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(epsilon)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression.	Lysine	120-126	lysine demethylase 6B	Homo sapiens	16-21
24798337-2	2014	KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(epsilon)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression.	Lysine	120-126	lysine demethylase 6B	Homo sapiens	23-28
24802408-2	2014	JMJD2A is a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysines 9 and 36.	Lysine	91-98	lysine demethylase 4A	Homo sapiens	0-6
24949976-3	2014	We report the structure of a trapped RING E3-E2~UBL-target intermediate representing RBX1-UBC12~NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.	Lysine	197-203	ring-box 1	Homo sapiens	85-89
24769394-3	2014	Here, we show that G6PD is negatively regulated by acetylation on lysine 403 (K403), an evolutionarily conserved residue.	Lysine	66-72	glucose-6-phosphate dehydrogenase	Homo sapiens	19-23
24835996-0	2014	Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.	Lysine	116-122	lysine acetyltransferase 5	Homo sapiens	29-34
24835996-0	2014	Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.	Lysine	116-122	lysine acetyltransferase 5	Homo sapiens	126-131
24843136-1	2014	Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.	Lysine	73-79	lysine demethylase 1A	Homo sapiens	0-29
24843136-1	2014	Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in collaboration with the corepressor CoREST/REST corepressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.	Lysine	73-79	lysine demethylase 1A	Homo sapiens	31-35
24646476-1	2014	Jmjd3 is required for cellular differentiation and senescence, and inhibits the induction of pluripotent stem cells by demethylating histone 3 lysine 27 trimethylation (H3K27me3).	Lysine	143-149	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	0-5
24371038-1	2014	GASC1 (gene amplified in squamous cell carcinoma 1) encodes a nuclear protein that epigenetically catalyses the lysine demethylation of histones.	Lysine	112-118	lysine demethylase 4C	Homo sapiens	0-5
24371038-1	2014	GASC1 (gene amplified in squamous cell carcinoma 1) encodes a nuclear protein that epigenetically catalyses the lysine demethylation of histones.	Lysine	112-118	lysine demethylase 4C	Homo sapiens	7-50
24371038-11	2014	Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer.	Lysine	124-130	lysine demethylase 4C	Homo sapiens	18-23
24704498-6	2014	L-364,718 and LY-288,513, selective antagonists of CCK1R and CCK2R, respectively, suppressed the effects of CCK-8 on CD4(+) T cell subset-specific transcription factors.	Lysine	14-16	cholecystokinin A receptor	Homo sapiens	51-56
24151879-1	2014	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	8-14	euchromatic histone lysine methyltransferase 2	Homo sapiens	33-36
24151879-1	2014	Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers.	Lysine	69-75	euchromatic histone lysine methyltransferase 2	Homo sapiens	33-36
24702180-5	2014	Further, the mutually exclusive interactions of MYST1 with sirtuin 1 vs AR regulate the acetylation of lysine 16 on histone H4.	Lysine	103-109	sirtuin 1	Homo sapiens	59-68
24920333-6	2014	We found that PKL, PIF3, and BZR1 coregulate skotomorphogenesis by repressing the trimethylation of histone H3 Lys-27 (H3K27me3) on target promoters.	Lysine	111-114	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	14-17
24920333-6	2014	We found that PKL, PIF3, and BZR1 coregulate skotomorphogenesis by repressing the trimethylation of histone H3 Lys-27 (H3K27me3) on target promoters.	Lysine	111-114	Brassinosteroid signaling positive regulator (BZR1) family protein	Arabidopsis thaliana	29-33
24671417-4	2014	By analyzing the kinetics of Miro1 ubiquitination, we further demonstrate that mitochondrial damage triggers rapid (within minutes) and persistent Lys-27-type ubiquitination of Miro1 on the OMM, dependent on PINK1 and Parkin.	Lysine	147-150	PTEN induced kinase 1	Homo sapiens	208-213
24847715-8	2014	These negatively charged residues appear to align the long axis of the STAT1 dimer in a position perpendicular to the DNA, thereby facilitating the interaction between lysine 567 and the phosphodiester backbone of a bound GAS element, which is a prerequisite for transient gene induction.	Lysine	168-174	signal transducer and activator of transcription 1	Homo sapiens	71-76
24733848-3	2014	The bromodomain and extraterminal (BET) proteins, Brd2, Brd3, Brd4, and BrdT, bind to acetylated lysine residues on histone or nonhistone proteins recruiting transcriptional regulators and thus activating or repressing gene transcription.	Lysine	97-103	bromodomain containing 2	Homo sapiens	50-54
24733848-3	2014	The bromodomain and extraterminal (BET) proteins, Brd2, Brd3, Brd4, and BrdT, bind to acetylated lysine residues on histone or nonhistone proteins recruiting transcriptional regulators and thus activating or repressing gene transcription.	Lysine	97-103	bromodomain containing 3	Homo sapiens	56-60
24816405-4	2014	IL-22 acted on cancer cells to promote activation of the transcription factor STAT3 and expression of the histone 3 lysine 79 (H3K79) methytransferase DOT1L.	Lysine	116-122	interleukin 22	Homo sapiens	0-5
24809689-5	2014	These events result in tri-methylation of histone H3 at lysine 27 (H3K27me3) of the DOK1 promoter and gene expression silencing.	Lysine	56-62	docking protein 1	Homo sapiens	84-88
24623813-5	2014	The ID2 complex is a poor substrate for monoubiquitination, consistent with the published crystal structure showing the solvent inaccessibility of the target lysines.	Lysine	158-165	inhibitor of DNA binding 2	Homo sapiens	4-7
24775912-8	2014	RESULTS: Grb2 can be SUMOylated by SUMO1 at lysine 56 (K56), which is located in the linker region between the N-terminal SH3 domain and the SH2 domain.	Lysine	44-50	growth factor receptor bound protein 2	Mus musculus	9-13
23954330-0	2014	The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.	Lysine	65-71	PHD finger protein 1	Homo sapiens	24-44
23954330-0	2014	The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.	Lysine	90-96	PHD finger protein 1	Homo sapiens	24-44
23954330-0	2014	The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.	Lysine	90-96	PHD finger protein 1	Homo sapiens	24-44
24536059-3	2014	SIRT7 associates with chromatin, where it catalyzes selective deacetylation of lysine 18 on histone H3 (H3K18), an emerging epigenetic biomarker of aggressive tumors and poor clinical outcome in patients with cancer.	Lysine	79-85	sirtuin 7	Homo sapiens	0-5
24620033-2	2014	Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop.	Lysine	73-79	kinase insert domain receptor	Homo sapiens	18-24
24620033-2	2014	Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop.	Lysine	157-163	kinase insert domain receptor	Homo sapiens	18-24
24582286-11	2014	We conclude that biotinylation of lysines synergizes with sulfoxidation of methionines in heat shock proteins such as HSP60 in the defense against reactive oxygen species.	Lysine	34-41	heat shock protein family D (Hsp60) member 1	Homo sapiens	118-123
24554764-5	2014	We describe an enzymatically active new Kdm3a isoform and show that subcellular distribution, protein levels, and lysine demethylation activity of Kdm3a depended on Hsp90.	Lysine	114-120	lysine (K)-specific demethylase 3A	Mus musculus	40-45
24554764-5	2014	We describe an enzymatically active new Kdm3a isoform and show that subcellular distribution, protein levels, and lysine demethylation activity of Kdm3a depended on Hsp90.	Lysine	114-120	lysine (K)-specific demethylase 3A	Mus musculus	147-152
24737471-6	2014	Hepatocellular-induced mBMMSCs showed lower expression of EZH2 and lower level of histone H3 lysine 27 trimethylation (H3K27me3) in the AFP and FOXa2 gene promoter regions compared to uninduced mBMMSCs.	Lysine	93-99	alpha fetoprotein	Mus musculus	136-139
24492612-4	2014	Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner.	Lysine	70-76	DNA methyltransferase 1	Homo sapiens	84-89
24492612-4	2014	Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner.	Lysine	70-76	DNA methyltransferase 1	Homo sapiens	91-103
24589551-0	2014	Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.	Lysine	38-44	spindlin 1	Homo sapiens	85-89
24589551-0	2014	Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.	Lysine	38-44	spindlin 1	Homo sapiens	106-115
24589551-8	2014	Taken together, our work connects a histone "lysine-arginine" methylation pattern readout by Spindlin1-to-Wnt signaling at the transcriptional level.	Lysine	45-51	spindlin 1	Homo sapiens	93-102
24497632-5	2014	The presence of lysine in place of arginine in the LLP1 motif resulted in significant impairment of Env expression and consequently virus replication kinetics, Env fusogenicity, and incorporation.	Lysine	16-22	endogenous retrovirus group K member 20	Homo sapiens	100-103
24497632-5	2014	The presence of lysine in place of arginine in the LLP1 motif resulted in significant impairment of Env expression and consequently virus replication kinetics, Env fusogenicity, and incorporation.	Lysine	16-22	endogenous retrovirus group K member 20	Homo sapiens	160-163
24497632-6	2014	By contrast, lysine exchanges in LLP2 only affected the level of Env incorporation and fusogenicity.	Lysine	13-19	endogenous retrovirus group K member 20	Homo sapiens	65-68
24497632-7	2014	Our findings demonstrate that the conservative lysine substitutions significantly affect Env functional properties indicating a unique functional role for the highly conserved arginines in the LLP motifs.	Lysine	47-53	endogenous retrovirus group K member 20	Homo sapiens	89-92
24626927-3	2014	The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1.	Lysine	58-64	Histone superfamily protein	Arabidopsis thaliana	160-164
24626927-3	2014	The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1.	Lysine	58-64	Histone superfamily protein	Arabidopsis thaliana	268-272
24451372-3	2014	Here we report that Lys-148 deacetylation is indispensable for facilitating MORF4L1 self-assembly into a homodimeric unit.	Lysine	20-23	mortality factor 4 like 1	Homo sapiens	76-83
24451372-4	2014	Among a stretch of ~10 amino acids in the NH2 terminus between the chromodomain and MORF4-related gene (MRG) domain within MORF4L1, Lys-148 is normally acetylated.	Lysine	132-135	mortality factor 4 like 1	Homo sapiens	123-130
24451372-7	2014	HDAC2, a deacetylase, interacts with and keeps MORF4L1 in a deacetylation status at Lys(148) that triggers MORF4L1 self-assembly.	Lysine	84-87	mortality factor 4 like 1	Homo sapiens	47-54
24451372-7	2014	HDAC2, a deacetylase, interacts with and keeps MORF4L1 in a deacetylation status at Lys(148) that triggers MORF4L1 self-assembly.	Lysine	84-87	mortality factor 4 like 1	Homo sapiens	107-114
24488729-0	2014	Improved chemical synthesis of hydrophobic Abeta peptides using addition of C-terminal lysines later removed by carboxypeptidase B.	Lysine	87-94	carboxypeptidase B1	Homo sapiens	112-130
24488729-5	2014	These Lys residues are then removed post-purification using immobilized carboxypeptidase B (CPB).	Lysine	6-9	carboxypeptidase B1	Homo sapiens	72-90
24488729-5	2014	These Lys residues are then removed post-purification using immobilized carboxypeptidase B (CPB).	Lysine	6-9	carboxypeptidase B1	Homo sapiens	92-95
24488729-8	2014	Reversible Lys addition with CPB removal should be a generally useful method for making hydrophobic peptides that is applicable to any sequence not ending in Arg or Lys.	Lysine	165-168	carboxypeptidase B1	Homo sapiens	29-32
23671032-2	2014	In cells, methylated lysine residues are recognized by reading domains such as the chromodomain of HP1beta, which bind to target proteins in a lysine-methylation-specific manner.	Lysine	21-27	chromobox 1	Homo sapiens	99-106
23671032-2	2014	In cells, methylated lysine residues are recognized by reading domains such as the chromodomain of HP1beta, which bind to target proteins in a lysine-methylation-specific manner.	Lysine	143-149	chromobox 1	Homo sapiens	99-106
24307402-7	2014	Together with Ada2, Ada3 and Sgf29, which are all components of SAGA, Gcn5 acetylates multiple lysine residues on nucleosomal histone H3, which is associated with an open chromatin structure.	Lysine	95-101	Sgf29p	Saccharomyces cerevisiae S288C	29-34
24111946-0	2014	Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.	Lysine	28-34	lysine demethylase 1A	Homo sapiens	62-67
24338482-0	2014	Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.	Lysine	61-67	KRAS proto-oncogene, GTPase	Homo sapiens	25-30
24338482-0	2014	Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.	Lysine	61-67	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
24338482-7	2014	High resolution tandem mass spectrometry (LC-MS/MS) analysis indicated that RasG ubiquitination occurs at C-terminal lysines equivalent to lysines found in human K-Ras but not in H-Ras and N-Ras homologues.	Lysine	139-146	KRAS proto-oncogene, GTPase	Homo sapiens	162-167
24502362-0	2014	Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.	Lysine	161-167	DNA methyltransferase 1	Homo sapiens	14-37
24502362-0	2014	Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.	Lysine	161-167	BRCA1 DNA repair associated	Homo sapiens	55-60
24502362-8	2014	Mechanistically, the abnormal E2F1 motif methylation-mediated loss of active histone H3 lysine 9 acetylation (H3K9ac) and transcription factor E2F1 enrichment synergistically inhibited the transcription of DNMT1.	Lysine	88-94	DNA methyltransferase 1	Homo sapiens	206-211
24506869-4	2014	Knockdown of SIAH2 or mutation of the ubiquitinated lysine residue on OGDH2 (336KA) reverses the hypoxic drop in alphaKGDH activity, stimulates glutamine oxidation, and reduces glutamine-dependent lipid synthesis.	Lysine	52-58	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	113-122
24496623-6	2014	Ezh2, which is a component of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 in histone 3 (H3K27me3), thereby functioning as transcriptional repressor of target genes.	Lysine	96-102	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	55-61	leucine-rich PPR-motif containing	Mus musculus	74-80
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	55-61	leucine-rich PPR-motif containing	Mus musculus	132-138
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	98-104	leucine-rich PPR-motif containing	Mus musculus	74-80
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Lysine	98-104	leucine-rich PPR-motif containing	Mus musculus	132-138
24445041-4	2014	When compared to C, the hepatic Pon1 promoter of male and female HF offspring had significantly more acetylated histone H4 as well as dimethylated histone H3 at lysine residue 4, which are both involved in transcriptional activation.	Lysine	161-167	paraoxonase 1	Rattus norvegicus	32-36
24709419-6	2014	Our data further show that SMURF2 monoubiquitinates UBCH5 at lysine 144 to form an active complex required for efficient degradation of a RAS-family E3, beta-transducing repeat containing protein 1 (beta-TrCP1).	Lysine	61-67	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	27-33
24300108-3	2014	In our previous study, we showed that a high dose administration of ethanol at P7 enhances G9a and leads to caspase-3-mediated degradation of dimethylated H3 on lysine 9 (H3K9me2).	Lysine	161-167	caspase 3	Mus musculus	108-117
23684884-2	2014	The methyltransferase EZH2 catalyzes the formation of trimethyl groups on lysine 27 of histone 3 (H3K27me3) and loss- and gain-of-function studies have provided insight into its role in normal mammary development and oncogenic transformation.	Lysine	74-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	22-26
24297171-9	2014	Of the MMPs tested, MMP-2 and MMP-9 most greatly favored the presence of charged residues with preference for the Gly-Asp-Lys series.	Lysine	122-125	matrix metallopeptidase 9	Homo sapiens	30-35
24297171-12	2014	More specifically, the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity.	Lysine	39-42	matrix metallopeptidase 9	Homo sapiens	85-90
24389103-1	2014	G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively.	Lysine	141-148	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
24466302-2	2014	The E3 ubiquitin ligase, tripartite motif containing protein 25 (TRIM25), activates human RIG-I through generation of anchored K63-linked polyubiquitin chains attached to lysine 172, or alternatively, through the generation of unanchored K63-linked polyubiquitin chains that interact non-covalently with RIG-I CARD domains.	Lysine	171-177	DExD/H-box helicase 58	Homo sapiens	90-95
24328108-7	2014	Mass spectrometry identified sites of mono- and diubiquitin attachment to two surface-exposed lysine residues (Lys24 and Lys39) on the GB1 peptide.	Lysine	94-100	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	135-138
24326073-3	2014	Pab1 showed the presence of six sites of methylated glutamate, five sites of lysine acetylation, and one phosphorylation of serine.	Lysine	77-83	polyadenylate-binding protein	Saccharomyces cerevisiae S288C	0-4
24399297-2	2014	Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta.	Lysine	14-20	DExD/H-box helicase 58	Homo sapiens	76-106
24621507-3	2014	Conversely, Tip60 activates p53 through direct association on target promoters as well as acetylation of p53 at lysine 120 (K120).	Lysine	112-118	lysine acetyltransferase 5	Homo sapiens	12-17
24739074-7	2014	The most important interactions for the binding of the inhibitors, which are probably also central components of the active site of KAT III, were identified as Ala134, Tyr135, Lys 280, Lys 288, Thr285 and Arg429, which provide hydrogen bond interactions.	Lysine	176-179	kynurenine aminotransferase 3	Homo sapiens	132-139
24739074-7	2014	The most important interactions for the binding of the inhibitors, which are probably also central components of the active site of KAT III, were identified as Ala134, Tyr135, Lys 280, Lys 288, Thr285 and Arg429, which provide hydrogen bond interactions.	Lysine	185-188	kynurenine aminotransferase 3	Homo sapiens	132-139
24038750-3	2014	We further discovered that the silencing of Oct4 significantly reduces the expression of Sirt1, a deacetylase known to inhibit p53 activity and the differentiation of ESCs, leading to increased acetylation of p53 at lysine 120 and 164.	Lysine	216-222	sirtuin 1	Homo sapiens	89-94
24367611-2	2013	Overexpression or activating mutations of EZH2, the catalytic component of the PRC2 complex, are linked to hyper-trimethylation of lysine 27 of histone H3 (H3K27me3) in many cancers.	Lysine	131-137	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	42-46
23891857-6	2013	When Lys(191) is deleted from hGnRHR and co-expressed with calnexin, IP production is similar to the rat sequence.	Lysine	5-8	calnexin	Rattus norvegicus	59-67
24135048-4	2013	Chromatin immunoprecipitation assay revealed that levels of lysine 9-acetylated histone H3 (H3K9Ac) and lysine 4-trimethylated H3 (H3K4me(3)) in the promoter regions of the CCL2 and CCL3 genes were increased in the injured SCN after PSL, indicating the enhancement of gene expression.	Lysine	60-66	chemokine (C-C motif) ligand 2	Mus musculus	173-177
24200691-4	2013	Here, we found that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is frequently overexpressed in NSCLC tumors and cell lines.	Lysine	35-41	lysine demethylase 2A	Homo sapiens	65-70
24200691-4	2013	Here, we found that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is frequently overexpressed in NSCLC tumors and cell lines.	Lysine	35-41	lysine demethylase 2A	Homo sapiens	84-90
24200691-4	2013	Here, we found that the histone H3 lysine 36 (H3K36) demethylase KDM2A (also called FBXL11 and JHDM1A) is frequently overexpressed in NSCLC tumors and cell lines.	Lysine	35-41	lysine demethylase 2A	Homo sapiens	95-101
24180271-3	2013	These small molecules bind selectively to TTR in complex biological environments and then undergo a rapid and chemoselective 1,4-Michael addition with the pKa-perturbed Lys-15 epsilon-amino group of TTR.	Lysine	169-172	transthyretin	Homo sapiens	42-45
24180271-3	2013	These small molecules bind selectively to TTR in complex biological environments and then undergo a rapid and chemoselective 1,4-Michael addition with the pKa-perturbed Lys-15 epsilon-amino group of TTR.	Lysine	169-172	transthyretin	Homo sapiens	199-202
24260132-1	2013	The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex.	Lysine	4-10	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	35-41
24260132-1	2013	The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex.	Lysine	4-10	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	140-144
24260437-5	2013	Our data further indicate that the propeptide sequence and the lysine residues K26 and K27 regulate the precursor pVII protein stability in a co-dependent manner.	Lysine	63-69	keratin 26	Homo sapiens	79-82
24102134-1	2013	Among epigenetic "writers", "readers", and "erasers", the lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and nonhistone proteins, have been implicated in a variety of human diseases.	Lysine	58-64	euchromatic histone lysine methyltransferase 2	Homo sapiens	84-95
24232453-2	2013	Several studies including ours have demonstrated that NR5A1 can be SUMOylated on lysine 194 (K194, the major site) and lysine 119 (K119, the minor site), and the cycle of SUMOylation regulates NR5A1"s transcriptional activity.	Lysine	81-87	nuclear receptor subfamily 5, group A, member 1	Mus musculus	54-59
24232453-2	2013	Several studies including ours have demonstrated that NR5A1 can be SUMOylated on lysine 194 (K194, the major site) and lysine 119 (K119, the minor site), and the cycle of SUMOylation regulates NR5A1"s transcriptional activity.	Lysine	81-87	nuclear receptor subfamily 5, group A, member 1	Mus musculus	193-198
24232453-2	2013	Several studies including ours have demonstrated that NR5A1 can be SUMOylated on lysine 194 (K194, the major site) and lysine 119 (K119, the minor site), and the cycle of SUMOylation regulates NR5A1"s transcriptional activity.	Lysine	119-125	nuclear receptor subfamily 5, group A, member 1	Mus musculus	54-59
24134843-1	2013	Sirt7 localizes in the nucleus (enriched in the nucleolus) and is an NAD(+)-dependent deacetylase with high selectivity for the acetylated lysine 18 of histone H3 (H3K18Ac).	Lysine	139-145	sirtuin 7	Homo sapiens	0-5
24883177-1	2014	Lysine specific demethylase 1 (LSD1) selectively removes methyl groups from mono- and dimethylated histone 3 lysine 4 (H3K4), resulting in gene silencing.	Lysine	109-115	lysine demethylase 1A	Homo sapiens	0-29
24077602-8	2013	They also showed that SAFB1 interacts with EZH2, SUZ12 and EED, three core components of the Polycomb repressive complex 2 (PRC2), which catalyzes the gene repression histone modification H3 lysine 27 trimethylation (H3K27me3).	Lysine	191-197	embryonic ectoderm development	Homo sapiens	59-62
23872478-8	2013	Furthermore, Chromatin immunoprecipitation assays demonstrate that silence of KDM2A increased the histone H3 Lysine 4 (H3K4) trimethylation in the SOX2 and NANOG locus and regulates its expression.	Lysine	109-115	lysine demethylase 2A	Homo sapiens	78-83
23872478-8	2013	Furthermore, Chromatin immunoprecipitation assays demonstrate that silence of KDM2A increased the histone H3 Lysine 4 (H3K4) trimethylation in the SOX2 and NANOG locus and regulates its expression.	Lysine	109-115	SRY-box transcription factor 2	Homo sapiens	147-151
24139802-5	2013	Inactivation of LSD1 reduces Sox2 expression, promotes G1 cell-cycle arrest, and induces genes for differentiation by selectively modulating the methylation states of histone H3 at lysines 4 (H3K4) and 9 (H3K9).	Lysine	181-188	lysine demethylase 1A	Homo sapiens	16-20
24139802-6	2013	Reduction of Sox2 further suppresses Sox2-dependent lineage-survival oncogenic potential, elevates trimethylation of histone H3 at lysine 27 (H3K27) and enhances growth arrest and cellular differentiation.	Lysine	131-137	SRY-box transcription factor 2	Homo sapiens	13-17
24025678-5	2013	An increase in ubiquitylation at histone H2B lysine 123 and methylations at both H3K4 and H3 lysine 79 (H3K79) was observed at the telomere-proximal regions of replicatively aged cells, coincident with decreased Sir2 abundance.	Lysine	45-51	histone H2B	Saccharomyces cerevisiae S288C	33-44
24025678-5	2013	An increase in ubiquitylation at histone H2B lysine 123 and methylations at both H3K4 and H3 lysine 79 (H3K79) was observed at the telomere-proximal regions of replicatively aged cells, coincident with decreased Sir2 abundance.	Lysine	93-99	histone H2B	Saccharomyces cerevisiae S288C	33-44
24100311-5	2013	The structure showed that the Gln275, Trp310 and Trp414 side chains might block the insertion of methylated lysine into the active centre of JMJD5, suppressing the histone demethylase activity of the truncated JMJD5 construct.	Lysine	108-114	lysine demethylase 8	Homo sapiens	141-146
24100311-5	2013	The structure showed that the Gln275, Trp310 and Trp414 side chains might block the insertion of methylated lysine into the active centre of JMJD5, suppressing the histone demethylase activity of the truncated JMJD5 construct.	Lysine	108-114	lysine demethylase 8	Homo sapiens	210-215
24004944-4	2013	KIS promotes transcription elongation, facilitates the binding of the trithorax group histone methyltransferases ASH1 and TRX to active genes, and counteracts repressive methylation of histone H3 on lysine 27 (H3K27) by Polycomb group proteins.	Lysine	199-205	trithorax	Drosophila melanogaster	70-79
23885084-2	2013	Multiple-sequence alignments of A19 homologs indicated conservation of a series of lysines and arginines, which could represent a nuclear localization or nucleic acid binding motif, and a pair of CXXC motifs that suggested a zinc finger or redox active sites.	Lysine	83-90	immunoglobulin kappa variable 2-28	Homo sapiens	32-35
32481960-3	2013	Proteins could be loaded on/released from PLP-CP via formation/hydrolysis of pH sensitive aldimine bridging lysine and surface-displayed PLP.	Lysine	108-114	proteolipid protein 1	Homo sapiens	42-45
23921388-0	2013	Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.	Lysine	113-119	heat shock protein family A (Hsp70) member 8	Homo sapiens	82-87
23921388-3	2013	In this study, we identified the methyltransferase METTL21A as the enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins.	Lysine	120-126	heat shock protein family A (Hsp70) member 8	Homo sapiens	158-163
23921388-3	2013	In this study, we identified the methyltransferase METTL21A as the enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins.	Lysine	120-126	heat shock protein family A (Hsp70) member 8	Homo sapiens	165-169
24007511-3	2013	Here, we report on the discovery of new small molecule inhibitors of LSD1 containing a propargylamine warhead, starting out from lysine containing substrate analogues.	Lysine	129-135	lysine demethylase 1A	Homo sapiens	69-73
24058583-4	2013	CLIC1 has a single putative transmembrane region that contains only two charged residues: arginine 29 (Arg29) and lysine 37 (Lys37).	Lysine	114-120	chloride intracellular channel 1	Homo sapiens	0-5
23986494-1	2013	Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63) or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the canonical IkappaB kinase (IKK) complex.	Lysine	74-80	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	204-207
24260783-0	2010	Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity A critical and dynamic epigenetic post-translational modification involves N(epsilon)-methylation of histone lysine residues by histone methyltransferases.	Lysine	196-202	lysine demethylase 4A	Homo sapiens	22-27
23750026-9	2013	In HEK293 cell extracts, this MS approach uncovered low abundance SUMOylated peptides and 37 SUMO3-modified Lys residues in target proteins, most of which were previously unknown.	Lysine	108-111	small ubiquitin like modifier 3	Homo sapiens	93-98
24076975-0	2013	The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunity.	Lysine	16-22	ubiquitin-conjugating enzyme E2 35-like	Solanum lycopersicum	11-15
24076975-3	2013	Fni3 encodes a homolog of the Ubc13-type ubiquitin-conjugating enzyme that catalyzes exclusively Lys-63-linked ubiquitination, whereas Suv is a ubiquitin-conjugating enzyme variant.	Lysine	97-100	ubiquitin-conjugating enzyme E2 35-like	Solanum lycopersicum	0-4
24076975-5	2013	Fni3 was shown to be an active E2 enzyme, but Suv displayed no ubiquitin-conjugating activity; Fni3 and Suv together directed Lys-63-linked ubiquitination.	Lysine	126-129	ubiquitin-conjugating enzyme E2 35-like	Solanum lycopersicum	0-4
24076975-5	2013	Fni3 was shown to be an active E2 enzyme, but Suv displayed no ubiquitin-conjugating activity; Fni3 and Suv together directed Lys-63-linked ubiquitination.	Lysine	126-129	ubiquitin-conjugating enzyme E2 35-like	Solanum lycopersicum	95-99
24076975-8	2013	These results suggest that Fni3/Sl-Ubc13-2 and Suv regulate the immune response mediated by Fen and other R proteins through Lys-63-linked ubiquitination.	Lysine	125-128	ubiquitin-conjugating enzyme E2 35-like	Solanum lycopersicum	27-31
24014454-0	2013	Set2 mediated H3 lysine 36 methylation: regulation of transcription elongation and implications in organismal development.	Lysine	17-23	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	0-4
24044023-1	2013	The transfer of acetyl groups from acetyl coenzyme A to the epsilon amino group of internal lysine residues is catalyzed by Tip60, which is in the MYST family of nuclear histone acetyltransferases (HATs).	Lysine	92-98	lysine acetyltransferase 5	Homo sapiens	124-129
24044023-1	2013	The transfer of acetyl groups from acetyl coenzyme A to the epsilon amino group of internal lysine residues is catalyzed by Tip60, which is in the MYST family of nuclear histone acetyltransferases (HATs).	Lysine	92-98	lysine acetyltransferase 5	Homo sapiens	147-151
23962979-6	2013	We found that Syk was present in both TRAF6- and TRAF3-containing signaling complexes; however, the LPS-dependent, lysine 63-linked ubiquitination of TRAF6 and TRAF3 was oppositely regulated by Syk.	Lysine	115-121	spleen associated tyrosine kinase	Homo sapiens	14-17
23962979-6	2013	We found that Syk was present in both TRAF6- and TRAF3-containing signaling complexes; however, the LPS-dependent, lysine 63-linked ubiquitination of TRAF6 and TRAF3 was oppositely regulated by Syk.	Lysine	115-121	TNF receptor associated factor 3	Homo sapiens	160-165
23962979-6	2013	We found that Syk was present in both TRAF6- and TRAF3-containing signaling complexes; however, the LPS-dependent, lysine 63-linked ubiquitination of TRAF6 and TRAF3 was oppositely regulated by Syk.	Lysine	115-121	spleen associated tyrosine kinase	Homo sapiens	194-197
23928698-4	2013	A triple Lys mutant of Aurora B (K102/103/(207R)) exhibited optimal resistance to SCF(FBXL2)-directed polyubiquitination, and overexpression of this variant resulted in a significant delay in anaphase onset, resulting in apoptosis.	Lysine	9-12	aurora kinase C	Mus musculus	23-31
23760503-10	2013	The model predicts that a hydrophobic patch composed of Trp-30 and Phe-6, along with the basic Lys-32 residue, docks into a groove formed by the Nav1.7 S1-S2 and S3-S4 loops.	Lysine	95-98	sodium voltage-gated channel alpha subunit 9	Homo sapiens	145-151
23979902-7	2013	Sequence analysis of the Alx4 gene for polydactylous heterozygotes revealed an A/T transversion mutation that resulted in substitution of a lysine codon with a stop (nonsense) codon at position 145.	Lysine	140-146	aristaless-like homeobox 4	Mus musculus	25-29
23760262-1	2013	PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis.	Lysine	45-51	lysine acetyltransferase 2A	Homo sapiens	9-13
23772023-3	2013	In this report, we define a STAT4-dependent sequence of events including histone H3 lysine 4 methylation, Jmjd3 association with STAT4 target loci, and a Jmjd3-dependent decrease in histone H3 lysine 27 trimethylation and DNA methyltransferase (Dnmt) 3a association with STAT4 target loci.	Lysine	84-90	signal transducer and activator of transcription 4	Mus musculus	28-33
23772023-3	2013	In this report, we define a STAT4-dependent sequence of events including histone H3 lysine 4 methylation, Jmjd3 association with STAT4 target loci, and a Jmjd3-dependent decrease in histone H3 lysine 27 trimethylation and DNA methyltransferase (Dnmt) 3a association with STAT4 target loci.	Lysine	193-199	signal transducer and activator of transcription 4	Mus musculus	28-33
23772023-3	2013	In this report, we define a STAT4-dependent sequence of events including histone H3 lysine 4 methylation, Jmjd3 association with STAT4 target loci, and a Jmjd3-dependent decrease in histone H3 lysine 27 trimethylation and DNA methyltransferase (Dnmt) 3a association with STAT4 target loci.	Lysine	193-199	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	154-159
23727017-5	2013	MITOL mediated lysine-63-linked polyubiquitin chain addition to Mfn2, but not its proteasomal degradation.	Lysine	15-21	mitofusin 2	Homo sapiens	64-68
23748155-5	2013	We show that in neurofibroma, the induction of Jmjd3 (jumonji domain containing 3, histone lysine demethylase) removes trimethyl groups on lysine-27 of histone-H3 and epigenetically activates the Ink4a/Arf-locus, forcing Schwann cells towards replicative senescence.	Lysine	91-97	lysine demethylase 6B	Homo sapiens	47-52
23423566-10	2013	Thus, activated LSD1 hypomethylates H3K9 at the MMP-9 promoter and this frees up that lysine 9 for acetylation.	Lysine	86-92	lysine demethylase 1A	Homo sapiens	16-20
23423566-10	2013	Thus, activated LSD1 hypomethylates H3K9 at the MMP-9 promoter and this frees up that lysine 9 for acetylation.	Lysine	86-92	matrix metallopeptidase 9	Homo sapiens	48-53
23732302-1	2013	Saccharopine dehydrogenase (SDH) is the last enzyme in the AAA pathway of l-lysine biosynthesis.	Lysine	74-82	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-26
23732302-1	2013	Saccharopine dehydrogenase (SDH) is the last enzyme in the AAA pathway of l-lysine biosynthesis.	Lysine	74-82	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	28-31
23732302-5	2013	From the point of view of energy, the SDH catalytic reaction for the synthesis of l-lysine is unfavorable compared with its reverse reaction for the synthesis of saccharopine.	Lysine	82-90	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	38-41
23671187-5	2013	During blastocyst formation, the relative levels of EED and KDM6B expression determine altered polycomb repressor 2 (PRC2) complex recruitment and incorporation of the repressive histone H3 lysine 27 trimethylation (H3K27Me3) mark at the chromatin domains of TE-specific master regulators CDX2 and GATA3, leading to their activation in the TE lineage and repression in the ICM lineage.	Lysine	190-196	embryonic ectoderm development	Homo sapiens	52-55
23671187-5	2013	During blastocyst formation, the relative levels of EED and KDM6B expression determine altered polycomb repressor 2 (PRC2) complex recruitment and incorporation of the repressive histone H3 lysine 27 trimethylation (H3K27Me3) mark at the chromatin domains of TE-specific master regulators CDX2 and GATA3, leading to their activation in the TE lineage and repression in the ICM lineage.	Lysine	190-196	lysine demethylase 6B	Homo sapiens	60-65
23671278-6	2013	In the ligand, Hp Arg-252 and Lys-262, both present in a previously identified CD163 binding loop of Hp, were revealed as essential residues for the high affinity receptor binding.	Lysine	30-33	CD163 molecule	Homo sapiens	79-84
23778120-10	2013	At low micromolar concentrations, the post-translationally modified hypervariable region of K-Ras aggregates and binds calmodulin in a non-specific manner, hence conventional NMR techniques cannot be used for studying this interaction, however, upon reductively methylating the lysines of calmodulin, we detected signals of the lipidated hypervariable region of K-Ras at physiologically relevant nanomolar concentrations.	Lysine	278-285	KRAS proto-oncogene, GTPase	Homo sapiens	92-97
23576563-2	2013	p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage.	Lysine	21-27	lysine acetyltransferase 5	Homo sapiens	60-65
23576563-2	2013	p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage.	Lysine	21-27	lysine acetyltransferase 5	Homo sapiens	67-71
23637228-4	2013	Sharp-1 is modified by sumoylation at two conserved lysine residues 240 and 255.	Lysine	52-58	basic helix-loop-helix family member e41	Homo sapiens	0-7
23637228-8	2013	Thus, enrichment of G9a, and histone H3 lysine 9 dimethylation (H3K9me2), a signature of G9a activity, is dramatically reduced at muscle promoters in cells expressing sumoylation-defective Sharp-1.	Lysine	40-46	euchromatic histone lysine methyltransferase 2	Homo sapiens	89-92
23466651-11	2013	BIX-01294, a specific inhibitor of EHMT2 (a key enzyme for histone H3 dimethylation at lysine-9), specifically decreases the overall H3K9Me2 level but not H3K27Me2.	Lysine	87-93	euchromatic histone lysine methyltransferase 2	Homo sapiens	35-40
23416531-2	2013	The predominant functional species is a non-covalent heterodimer of 33 and 13kDa, termed Xa33/13, which has predicted newly exposed C-terminal lysines that are important for tissue plasminogen activator (tPA)-mediated plasminogen activation to plasmin.	Lysine	143-150	chromosome 20 open reading frame 181	Homo sapiens	174-202
23416531-2	2013	The predominant functional species is a non-covalent heterodimer of 33 and 13kDa, termed Xa33/13, which has predicted newly exposed C-terminal lysines that are important for tissue plasminogen activator (tPA)-mediated plasminogen activation to plasmin.	Lysine	143-150	chromosome 20 open reading frame 181	Homo sapiens	204-207
23007842-2	2013	Later, it turned out that the homologous mammalian proteins SUMO1 to SUMO4 are reversible protein modifiers that can form isopeptide bonds with lysine residues of respective target proteins (Mahajan et al.	Lysine	144-150	small ubiquitin like modifier 4	Homo sapiens	69-74
23329852-2	2013	Focal accumulation of 53BP1 depends on the specific interaction of its tandem Tudor domain with dimethylated lysine 20 in histone H4 (H4K20me2).	Lysine	109-115	H4 clustered histone 9	Homo sapiens	122-132
23129483-2	2013	Lactostatin (Ile-Ile-Ala-Glu-Lys), derived from beta-lactoglobulin in cow"s milk, is a bioactive peptide with hypocholesterolemic activity higher than sitosterol, a known anti-hypercholesterolemic drug.	Lysine	29-32	beta-lactoglobulin	Bos taurus	48-66
23546878-4	2013	Exposing cells to either chemical or cellular sources of ( )NO resulted in a significant increase in dimethyl Lys-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A.	Lysine	110-113	lysine demethylase 3A	Homo sapiens	168-173
23644528-3	2013	KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26.	Lysine	63-70	lysine demethylase 4A	Homo sapiens	5-10
23644528-3	2013	KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26.	Lysine	63-69	lysine demethylase 4A	Homo sapiens	5-10
23630229-4	2013	We show that Sirt1 binds to the Hoxa9 gene, counteracts acetylation of its histone target H4 lysine 16, and in turn promotes polycomb-specific repressive histone modification.	Lysine	93-99	sirtuin 1	Homo sapiens	13-18
23455153-4	2013	We showed that UBE2O functions as an E2-E3 hybrid to monoubiquitinate SMAD6 at lysine 174 and that the cysteine 885 residue of human UBE2O is necessary for SMAD6 monoubiquitination.	Lysine	79-85	ubiquitin conjugating enzyme E2 O	Homo sapiens	15-20
23238566-2	2013	Here, utilizing mass-spectrometry analysis and site-specific acetyl-p21 antibody, two lysine residues of p21, located at amino-acid sites 161 and 163, were identified as Tip60-mediated acetylation targets for the first time.	Lysine	86-92	lysine acetyltransferase 5	Homo sapiens	170-175
23408432-1	2013	JARID1B (also known as KDM5B or PLU1) is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of trimethylated lysine 27 in histone H3 (H3K4me3), a mark for actively transcribed genes.	Lysine	82-88	lysine (K)-specific demethylase 5B	Mus musculus	0-7
23408432-1	2013	JARID1B (also known as KDM5B or PLU1) is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of trimethylated lysine 27 in histone H3 (H3K4me3), a mark for actively transcribed genes.	Lysine	82-88	lysine (K)-specific demethylase 5B	Mus musculus	23-28
23408432-1	2013	JARID1B (also known as KDM5B or PLU1) is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of trimethylated lysine 27 in histone H3 (H3K4me3), a mark for actively transcribed genes.	Lysine	82-88	lysine (K)-specific demethylase 5B	Mus musculus	32-36
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Lysine	111-117	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	49-54
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Lysine	111-117	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	50-54
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Lysine	219-225	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	49-54
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Lysine	219-225	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	50-54
23224434-5	2013	Furthermore, menin could repress p65 acetylation through recruitment of Sirt1, an enzyme that deacetylases p65 in lysine 310 (K310).	Lysine	114-120	sirtuin 1	Homo sapiens	72-77
23358244-0	2013	Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.	Lysine	70-76	keratin 8	Homo sapiens	57-66
23358244-2	2013	We investigated the regulation of keratin 8 (K8), a type II simple epithelial IF, by lysine acetylation.	Lysine	85-91	keratin 8	Homo sapiens	34-43
23358244-2	2013	We investigated the regulation of keratin 8 (K8), a type II simple epithelial IF, by lysine acetylation.	Lysine	85-91	keratin 8	Homo sapiens	45-47
23358244-8	2013	Inhibition of K8 Lys-207 acetylation resulted in site-specific phosphorylation changes of K8.	Lysine	17-20	keratin 8	Homo sapiens	14-16
23358244-8	2013	Inhibition of K8 Lys-207 acetylation resulted in site-specific phosphorylation changes of K8.	Lysine	17-20	keratin 8	Homo sapiens	90-92
23358244-9	2013	Therefore, K8 acetylation at Lys-207, a highly conserved residue among type II keratins and other IFs, is up-regulated upon hyperglycemia and down-regulated by SIRT2.	Lysine	29-32	keratin 8	Homo sapiens	11-13
23128324-3	2013	Whereas animal CHD3 remodelers are a component of the Mi-2/NuRD complex that promotes histone deacetylation, PICKLE promotes trimethylation of histone H3 lysine 27 suggesting that it acts via a distinct epigenetic pathway.	Lysine	154-160	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	109-115
23307557-3	2013	Here we show that TRF2 specifically interacts with the histone acetyltransferase p300, and that p300 acetylates the lysine residue at position 293 of TRF2.	Lysine	116-122	telomeric repeat binding factor 2	Homo sapiens	18-22
23307557-3	2013	Here we show that TRF2 specifically interacts with the histone acetyltransferase p300, and that p300 acetylates the lysine residue at position 293 of TRF2.	Lysine	116-122	telomeric repeat binding factor 2	Homo sapiens	150-154
23291096-5	2013	We observe distinct chromatin influences, including a Set2/Rpd3-mediated antagonistic interaction between histone H3 lysine 36 trimethylation and the Rap1 transcriptional activation site in kanMX.	Lysine	117-123	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	54-58
23319629-4	2013	The more amino-terminal of its two plant homeodomains (PHDs), PHD1, helps Aire target poorly transcribed loci by "reading" the methylation status of a particular lysine residue of histone-3, a process that does not depend on the more carboxyl-terminal PHD-2.	Lysine	162-168	egl-9 family hypoxia-inducible factor 2	Mus musculus	62-66
23319629-4	2013	The more amino-terminal of its two plant homeodomains (PHDs), PHD1, helps Aire target poorly transcribed loci by "reading" the methylation status of a particular lysine residue of histone-3, a process that does not depend on the more carboxyl-terminal PHD-2.	Lysine	162-168	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Mus musculus	74-78
23172226-2	2013	In an effort to identify mechanisms that regulate MLK3 activity in beta cells, we discovered that IL-1beta stimulates Lys-63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase.	Lysine	118-121	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	50-54
23172226-2	2013	In an effort to identify mechanisms that regulate MLK3 activity in beta cells, we discovered that IL-1beta stimulates Lys-63-linked ubiquitination of MLK3 via a conserved, TRAF6-binding peptapeptide motif in the catalytic domain of the kinase.	Lysine	118-121	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	150-154
23154975-11	2013	LPS increased Smad7 binding to the TGF-beta(2) promoter and was associated with dimethylation of the lysine H3K9, a marker of transcriptional silencing, on the nucleosome of TGF-beta(2).	Lysine	101-107	transforming growth factor beta 2	Homo sapiens	174-185
23159946-1	2013	HBO1 acetylates lysine residues of histones and is involved in DNA replication and gene transcription.	Lysine	16-22	K(lysine) acetyltransferase 7	Mus musculus	0-4
23159946-9	2013	The temporal expression of JADE1S correlated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3 on lysine 14, demonstrating that the JADE1S-HBO1 complex specifically marks H4 during epithelial cell proliferation.	Lysine	83-90	K(lysine) acetyltransferase 7	Mus musculus	184-188
23159946-9	2013	The temporal expression of JADE1S correlated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3 on lysine 14, demonstrating that the JADE1S-HBO1 complex specifically marks H4 during epithelial cell proliferation.	Lysine	83-89	K(lysine) acetyltransferase 7	Mus musculus	184-188
23534753-4	2013	Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes.	Lysine	301-304	X-ray repair cross complementing 1	Homo sapiens	23-28
23534753-4	2013	Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes.	Lysine	301-304	X-ray repair cross complementing 1	Homo sapiens	23-28
23182424-0	2013	Role of the conserved lysine within the Walker A motif of human DMC1.	Lysine	22-28	DNA meiotic recombinase 1	Homo sapiens	64-68
23182424-4	2013	We constructed two variants of hDMC1 altering the conserved lysine residue of the Walker A motif to arginine (hDMC1(K132R)) or alanine (hDMC1(K132A)).	Lysine	60-66	DNA meiotic recombinase 1	Homo sapiens	31-36
23209321-6	2013	Treatment of infected mice with a complex of polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethyl cellulose (Hiltonol), a potent TLR3 agonist, significantly improved survival of both WT and IRAK4(KDKI) mice, thereby providing a potential treatment strategy in both normal and immunocompromised patients.	Lysine	82-95	interleukin-1 receptor-associated kinase 4	Mus musculus	206-211
23371947-4	2013	SNL1 interacts with HISTONE DEACETYLASE19 in vitro and in planta, and loss-of-function mutants of SNL1 and SNL2 show increased acetylation levels of histone 3 lysine 9/18 (H3K9/18) and H3K14.	Lysine	159-165	SIN3-like 2	Arabidopsis thaliana	107-111
23437046-8	2013	These data provide a first look at quantitating the specificity and selectivity of multiple lysines on a single substrate (H3) by Gcn5.	Lysine	92-99	lysine acetyltransferase 2A	Homo sapiens	130-134
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	small ubiquitin like modifier 2	Homo sapiens	134-140
23129632-4	2012	JMJD2C decreases trimethylation of histone H3 at lysine 9, and enhances HIF-1 binding to hypoxia response elements, thereby activating transcription of BNIP3, LDHA, PDK1, and SLC2A1, which encode proteins that are required for metabolic reprogramming, as well as LOXL2 and L1CAM, which encode proteins that are required for lung metastasis.	Lysine	49-55	lysine demethylase 4C	Homo sapiens	0-6
22528876-1	2012	Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in collagens and elastin, resulting in the covalent crosslinking and stabilization of these extracellular matrix (ECM) structural components, thus provide collagen and elastic fibers much of their tensile strength and structural integrity.	Lysine	62-68	lysyl oxidase	Homo sapiens	0-13
22528876-1	2012	Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in collagens and elastin, resulting in the covalent crosslinking and stabilization of these extracellular matrix (ECM) structural components, thus provide collagen and elastic fibers much of their tensile strength and structural integrity.	Lysine	62-68	lysyl oxidase	Homo sapiens	15-18
22528876-1	2012	Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in collagens and elastin, resulting in the covalent crosslinking and stabilization of these extracellular matrix (ECM) structural components, thus provide collagen and elastic fibers much of their tensile strength and structural integrity.	Lysine	62-68	lysyl oxidase	Homo sapiens	37-40
22447389-3	2012	Lysine-specific demethylase 1 (LSD1) removes mono- and dimethyl marks from lysine 4 or 9 of histone H3.	Lysine	75-81	lysine demethylase 1A	Homo sapiens	0-29
22447389-3	2012	Lysine-specific demethylase 1 (LSD1) removes mono- and dimethyl marks from lysine 4 or 9 of histone H3.	Lysine	75-81	lysine demethylase 1A	Homo sapiens	31-35
23106124-7	2012	While yeast Aco1p is essential for the citric acid cycle and, thus, for glutamate synthesis, Aco2p specifically and exclusively contributes to lysine biosynthesis.	Lysine	143-149	aconitate hydratase ACO2	Saccharomyces cerevisiae S288C	93-98
23103168-1	2012	JMJD3 (KDM6B) antagonizes Polycomb silencing by demethylating lysine 27 on histone H3.	Lysine	62-68	lysine demethylase 6B	Homo sapiens	0-5
23103168-1	2012	JMJD3 (KDM6B) antagonizes Polycomb silencing by demethylating lysine 27 on histone H3.	Lysine	62-68	lysine demethylase 6B	Homo sapiens	7-12
22310283-4	2012	Here, we reported that protein kinase A (PKA)-mediated phosphorylation regulates TAL1 interaction with the lysine-specific demethylase (LSD1) that removes methyl group from methylated Lys 4 on histone H3 tails.	Lysine	184-187	lysine demethylase 1A	Homo sapiens	136-140
23007391-5	2012	p300 acetylates lysine residues at the N terminus of the myocardin protein.	Lysine	16-22	myocardin	Homo sapiens	57-66
22718341-9	2012	Mass spectrometry reveals absence of hydroxylation of the collagen telopeptide lysine involved in cross-linking, suggesting that FKBP65 is required for lysyl hydroxylase activity or access to type I collagen telopeptide lysines, perhaps through its function as a peptidylprolyl isomerase.	Lysine	220-227	FKBP prolyl isomerase 10	Homo sapiens	129-135
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Lysine	137-143	E1A binding protein p300	Mus musculus	40-44
22403019-8	2012	Treating HK-2 with antioxidants, such as Cysteine and its analog, N-acetyl-L-cysteine (NAC), rescued the HK-2 from apoptosis induced by Lysine.	Lysine	136-142	X-linked Kx blood group	Homo sapiens	87-90
23077255-0	2012	Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.	Lysine	28-34	spindlin 1	Homo sapiens	95-104
22683437-2	2012	Other individual reports identified lysine acetylation as a PTM regulating transcription factors and co-activators including p53, c-Myc, PGC1alpha and Ku70.	Lysine	36-42	X-ray repair cross complementing 6	Homo sapiens	151-155
22815475-0	2012	Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1beta with the nucleosome.	Lysine	15-21	chromobox 1	Homo sapiens	121-129
22323620-2	2012	In the present study, we investigated the  spermatogenic distribution of the lysine-specific histone H3 methyltransferase  Ezh2 in mice.	Lysine	77-83	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	123-127
22736769-9	2012	C-terminal lysine residues were dispensable for plasma membrane targeting and the CXCL12 scavenger function but involved in constitutive degradation of CXCR7.	Lysine	11-17	atypical chemokine receptor 3	Homo sapiens	152-157
22897849-3	2012	Here, we identify that ASXL1 mutations result in loss of polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) tri-methylation.	Lysine	114-120	ASXL transcriptional regulator 1	Homo sapiens	23-28
22675172-5	2012	While no significant change was detected in MGMT promoter methylation between parental and derivative-resistant samples, chromatin immunoprecipitation showed an association between MGMT upregulation and elevated acetylation of lysine 9 of histone H3 (H3K9-ac) and decreased dimethylation (H3K9-me2) in GBM12 and GBM14.	Lysine	227-233	O-6-methylguanine-DNA methyltransferase	Homo sapiens	181-185
22472323-11	2012	Treatment with trichostain A, an inhibitor for histone deacetylase, induced acetylation of histones H3 and H4, and tri-methylation of lysine 4 of histone H3, which was associated with the active transcription of GATA4 in GATA4-negative AFP-producing cells.	Lysine	134-140	GATA binding protein 4	Homo sapiens	212-217
22689573-2	2012	The Ub-interacting motif (UIM) domain of Rap80, which is a component of the BRCA1-A complex, interacts with Ub Lys-63 linkage conjugates and mediates the recruitment of BRCA1 to DSBs.	Lysine	111-114	BRCA1 DNA repair associated	Homo sapiens	76-81
22689573-2	2012	The Ub-interacting motif (UIM) domain of Rap80, which is a component of the BRCA1-A complex, interacts with Ub Lys-63 linkage conjugates and mediates the recruitment of BRCA1 to DSBs.	Lysine	111-114	BRCA1 DNA repair associated	Homo sapiens	169-174
22689573-5	2012	The SIM-UIM-UIM motif binds to both Ub Lys-63 linkage and SUMO2 conjugates.	Lysine	39-42	small ubiquitin like modifier 2	Homo sapiens	58-63
22822152-4	2012	Loss of laat-1 caused accumulation of lysine and arginine in enlarged, degradation-defective lysosomes.	Lysine	38-44	Lysosomal amino acid transporter 1	Caenorhabditis elegans	8-14
22822152-5	2012	In mutants of ctns-1 (C. elegans homolog of CTNS), LAAT-1 was required to reduce lysosomal cystine levels and suppress lysosome enlargement by cysteamine, a drug that alleviates cystinosis by converting cystine to a lysine analog.	Lysine	216-222	Lysosomal amino acid transporter 1	Caenorhabditis elegans	51-57
22822152-6	2012	LAAT-1 also maintained availability of cytosolic lysine/arginine during embryogenesis.	Lysine	49-55	Lysosomal amino acid transporter 1	Caenorhabditis elegans	0-6
22467861-10	2012	p39 had a greater propensity to accumulate in the nucleus than p35, and phosphorylation at Thr84, specific to p39, regulated the potential nuclear localization activity of the Lys cluster in p39.	Lysine	176-179	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	63-66
22589545-1	2012	The repair of DNA double strand breaks by homologous recombination relies on the unique topology of the chains formed by Lys-63 ubiquitylation of chromatin to recruit repair factors such as breast cancer 1 (BRCA1) to sites of DNA damage.	Lysine	121-124	BRCA1 DNA repair associated	Homo sapiens	190-205
22589545-1	2012	The repair of DNA double strand breaks by homologous recombination relies on the unique topology of the chains formed by Lys-63 ubiquitylation of chromatin to recruit repair factors such as breast cancer 1 (BRCA1) to sites of DNA damage.	Lysine	121-124	BRCA1 DNA repair associated	Homo sapiens	207-212
22820736-7	2012	Using a combination of tandem mass spectrometry and methyl-specific antibodies, we find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1.	Lysine	136-142	sirtuin 1	Homo sapiens	194-199
22967467-9	2012	The MTTP was 11.3 months for patients with Lys/Lys genotypes of XPD751 gene and 2.9 months for patients with Lys/Gln and Gln/Gln genotypes of XPD751 gene, the difference between Lys/Lys and at least one Gln was significant (P &lt; 0.05).	Lysine	43-46	microsomal triglyceride transfer protein	Homo sapiens	4-8
22967467-9	2012	The MTTP was 11.3 months for patients with Lys/Lys genotypes of XPD751 gene and 2.9 months for patients with Lys/Gln and Gln/Gln genotypes of XPD751 gene, the difference between Lys/Lys and at least one Gln was significant (P &lt; 0.05).	Lysine	47-50	microsomal triglyceride transfer protein	Homo sapiens	4-8
22967467-9	2012	The MTTP was 11.3 months for patients with Lys/Lys genotypes of XPD751 gene and 2.9 months for patients with Lys/Gln and Gln/Gln genotypes of XPD751 gene, the difference between Lys/Lys and at least one Gln was significant (P &lt; 0.05).	Lysine	47-50	microsomal triglyceride transfer protein	Homo sapiens	4-8
22967467-9	2012	The MTTP was 11.3 months for patients with Lys/Lys genotypes of XPD751 gene and 2.9 months for patients with Lys/Gln and Gln/Gln genotypes of XPD751 gene, the difference between Lys/Lys and at least one Gln was significant (P &lt; 0.05).	Lysine	47-50	microsomal triglyceride transfer protein	Homo sapiens	4-8
22967467-9	2012	The MTTP was 11.3 months for patients with Lys/Lys genotypes of XPD751 gene and 2.9 months for patients with Lys/Gln and Gln/Gln genotypes of XPD751 gene, the difference between Lys/Lys and at least one Gln was significant (P &lt; 0.05).	Lysine	47-50	microsomal triglyceride transfer protein	Homo sapiens	4-8
22539352-1	2012	RAP80 (receptor-associated protein 80) is a ubiquitin-binding protein that can specifically recognize and bind to Lys-63-linked polyubiquitin chains, thus targeting the BRCA1-A complex to DNA damage sites.	Lysine	114-117	breast cancer 1, early onset	Mus musculus	169-174
22705106-2	2012	RIG-I is activated through sequential binding of viral RNA and unanchored lysine-63 (K63) polyubiquitin chains, but how polyubiquitin activates RIG-I and whether MDA5 is activated through a similar mechanism remain unresolved.	Lysine	74-80	DExD/H-box helicase 58	Homo sapiens	0-5
22556417-7	2012	In rP2X2, one of these histidines is replaced by a lysine, and in a background in which zinc potentiation was eliminated, mutation of Lys-197 to histidine converted rP2X2 from low potency to high potency inhibition.	Lysine	51-57	purinergic receptor P2X 2	Rattus norvegicus	165-170
22713873-1	2012	The histone H3 Lys 27 (H3K27) demethylase JMJD3 has been shown to play important roles in transcriptional regulation and cell differentiation.	Lysine	15-18	lysine demethylase 6B	Homo sapiens	42-47
22554148-5	2012	Using Bolton-Hunter reagent, we can derivatize lysine residues with phenolic functional groups to modulate the phenolic (tyrosine-like) content of (GB1)(8).	Lysine	47-53	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	148-151
22301686-1	2012	AIMS: The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver.	Lysine	115-121	KRAS proto-oncogene, GTPase	Rattus norvegicus	262-265
22383521-7	2012	Additionally, we observed that a BST-2 mutant deleted for its cytosolically exposed lysine residues is also ubiquitinated.	Lysine	84-90	bone marrow stromal cell antigen 2	Homo sapiens	33-38
22383521-9	2012	However, a BST-2 mutant bearing substitutions for its cytoplasmically exposed Ser, Thr, and Lys residues was still down-regulated, ubiquitinated, and degraded in a Vpu-dependent manner.	Lysine	92-95	bone marrow stromal cell antigen 2	Homo sapiens	11-16
22383521-9	2012	However, a BST-2 mutant bearing substitutions for its cytoplasmically exposed Ser, Thr, and Lys residues was still down-regulated, ubiquitinated, and degraded in a Vpu-dependent manner.	Lysine	92-95	Vpu	Human immunodeficiency virus 1	164-167
22460798-7	2012	Moreover, an engineered ubiquitination-resistant form of Bax retained its apoptotic function, but Bax KO cells complemented with lysine-mutant Bax did not manifest the antiapoptotic effects of parkin that were observed in cells expressing WT Bax.	Lysine	129-135	BCL2-associated X protein	Mus musculus	98-101
22460798-7	2012	Moreover, an engineered ubiquitination-resistant form of Bax retained its apoptotic function, but Bax KO cells complemented with lysine-mutant Bax did not manifest the antiapoptotic effects of parkin that were observed in cells expressing WT Bax.	Lysine	129-135	BCL2-associated X protein	Mus musculus	98-101
22460798-7	2012	Moreover, an engineered ubiquitination-resistant form of Bax retained its apoptotic function, but Bax KO cells complemented with lysine-mutant Bax did not manifest the antiapoptotic effects of parkin that were observed in cells expressing WT Bax.	Lysine	129-135	BCL2-associated X protein	Mus musculus	98-101
22433953-4	2012	In the budding yeast Saccharomyces cerevisiae, trimethylation of lysine 4 of histone H3 (H3K4me3) has been suggested to play a causal role in targeting Spo11 activity to small regions of preferred DSB formation called hotspots.	Lysine	65-71	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	152-157
22252741-2	2012	JMJD3 is crucial for erasing histone-3 lysine-27 trimethylation (H3K27me3), a modification associated with transcriptional repression and is responsible for the activation of a diverse set of genes.	Lysine	39-45	lysine demethylase 6B	Homo sapiens	0-5
22252741-8	2012	In addition, chromatin immunoprecipitation revealed that JMJD3-kd could inhibit several NF-kappaB-regulated inflammatory genes by recruiting repressive histone-3 lysine-27 trimethylation to their promoters.	Lysine	162-168	lysine demethylase 6B	Homo sapiens	57-62
22095636-7	2012	HuR is stabilized by Mdm2-mediated NEDDylation in at least three lysine residues, ensuring its nuclear localization and protection from degradation.	Lysine	65-71	MDM2 proto-oncogene	Homo sapiens	21-25
22790203-3	2012	cIAP1 and XIAP directly conjugate polyubiquitin chains to Lysine 147 of activated Rac1 and target it for proteasomal degradation.	Lysine	58-64	X-linked inhibitor of apoptosis	Homo sapiens	10-14
22790203-3	2012	cIAP1 and XIAP directly conjugate polyubiquitin chains to Lysine 147 of activated Rac1 and target it for proteasomal degradation.	Lysine	58-64	Rac family small GTPase 1	Homo sapiens	82-86
22227389-1	2012	Human tRNA(Lys3)(UUU) (htRNA(Lys3)(UUU)) decodes the lysine codons AAA and AAG during translation and also plays a crucial role as the primer for HIV-1 (human immunodeficiency virus type 1) reverse transcription.	Lysine	53-59	N-methylpurine DNA glycosylase	Homo sapiens	75-78
22185822-5	2012	Moreover, we found that XIAP-induced ubiquitination and degradation is prevented by removal of the first four amino acids in the N-terminus of ARTS, which contains a single lysine residue at position 3.	Lysine	173-179	X-linked inhibitor of apoptosis	Homo sapiens	24-28
22185822-6	2012	Thus, this lysine at position 3 is a likely target for ubiquitination by XIAP.	Lysine	11-17	X-linked inhibitor of apoptosis	Homo sapiens	73-77
22244851-0	2012	Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner.	Lysine	102-108	G protein nucleolar 1 (putative)	Homo sapiens	64-68
22244851-3	2012	To understand the nuclear transport mechanism of GNL1, we have identified a novel arginine/lysine-rich nucleolar localization signal in the NH(2)-terminus that is shown to translocate GNL1 and a heterologous protein to the nucleus/nucleolus in a pathway that is independent of importin-alpha and importin-beta.	Lysine	91-97	G protein nucleolar 1 (putative)	Homo sapiens	49-53
22244851-3	2012	To understand the nuclear transport mechanism of GNL1, we have identified a novel arginine/lysine-rich nucleolar localization signal in the NH(2)-terminus that is shown to translocate GNL1 and a heterologous protein to the nucleus/nucleolus in a pathway that is independent of importin-alpha and importin-beta.	Lysine	91-97	G protein nucleolar 1 (putative)	Homo sapiens	184-188
22365829-5	2012	Phosphorylated HERS binds to histone gene regulatory regions and anchors HP1 and Su(var)3-9 to induce chromatin inactivation through histone H3 lysine 9 methylation.	Lysine	144-150	Suppressor of variegation 3-9	Drosophila melanogaster	81-91
22308441-0	2012	Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.	Lysine	76-82	inositol-tetrakisphosphate 1-kinase	Homo sapiens	14-53
22308441-0	2012	Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.	Lysine	76-82	inositol-tetrakisphosphate 1-kinase	Homo sapiens	55-60
22308441-4	2012	We show here that ITPK1 is modified by acetylation of internal lysine residues.	Lysine	63-69	inositol-tetrakisphosphate 1-kinase	Homo sapiens	18-23
22308441-11	2012	These results demonstrate that lysine acetylation alters both the stability as well as the activity of ITPK1 in cells.	Lysine	31-37	inositol-tetrakisphosphate 1-kinase	Homo sapiens	103-108
22117046-5	2012	This effect was associated with the ability of DZNep to selectively reduce trimethylation of histone H3 lysine 27, deplete the histone methyltransferase Ezh2 specific to trimethylation of histone H3 lysine 27, and activate proapoptotic gene Bim repressed by Ezh2 in antigenic-activated T cells.	Lysine	199-205	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	153-157
22222205-3	2012	HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8.	Lysine	184-190	drosha ribonuclease III	Homo sapiens	38-44
22222205-3	2012	HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8.	Lysine	184-190	DGCR8 microprocessor complex subunit	Homo sapiens	45-50
22222205-3	2012	HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8.	Lysine	184-190	DGCR8 microprocessor complex subunit	Homo sapiens	119-124
22222205-3	2012	HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8.	Lysine	184-190	DGCR8 microprocessor complex subunit	Homo sapiens	119-124
21706055-5	2012	In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin.	Lysine	149-155	phosphatidylinositol binding clathrin assembly protein	Mus musculus	31-35
21706055-5	2012	In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin.	Lysine	149-155	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10	Mus musculus	36-40
22044919-2	2012	Given that SIRT1 inhibits the transactivation potential of NF-kappaB by deacetylating acetylated lysines in p65, the NF-kappaB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes.	Lysine	97-104	sirtuin 1	Homo sapiens	11-16
22110129-5	2012	Here we show that deletion of Jarid2 results in reduced methylation of lysine 9 on histone H3 (H3K9) at the Notch1 genomic locus in embryonic hearts.	Lysine	71-77	jumonji, AT rich interactive domain 2	Mus musculus	30-36
22020126-3	2012	The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site.	Lysine	190-196	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	38-42
22020126-3	2012	The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site.	Lysine	190-196	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	44-49
22020126-3	2012	The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site.	Lysine	190-196	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	50-54
22020126-5	2012	Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro.	Lysine	128-134	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	154-159
21718305-5	2012	KEY RESULTS: A network of polar interactions stabilized by a direct ionic bond between DF 2156A and Lys(99) on CXCR1 and the non-conserved residue Asp(293) on CXCR2 are the key determinants of DF 2156A binding.	Lysine	100-103	C-X-C motif chemokine receptor 1	Homo sapiens	111-116
21856897-18	2012	1, increasing the SID Lys:ME ratio increased (quadratic; P &lt; 0.04) ADG and G:F, with pigs fed the 2.99 g/Mcal ratio having the greatest ADG and G:F. In Exp.	Lysine	22-25	ADG	Sus scrofa	70-73
21856897-20	2012	3, ADG and G:F increased (P &lt; 0.05) in a quadratic manner as the SID Lys:ME ratio fed increased.	Lysine	72-75	ADG	Sus scrofa	3-6
21856897-22	2012	4, increasing the SID Lys:ME ratio increased ADG (linear; P &lt; 0.001) and G:F (quadratic; P = 0.03).	Lysine	22-25	ADG	Sus scrofa	45-48
21859682-1	2012	Lysine demethylase 1 (LSD1) and Jumonji C domain-containing oxygenase D2C (JMJD2C) participate in regulating the methylation status of histone H3 lysine residues.	Lysine	146-152	lysine demethylase 1A	Homo sapiens	0-20
21859682-1	2012	Lysine demethylase 1 (LSD1) and Jumonji C domain-containing oxygenase D2C (JMJD2C) participate in regulating the methylation status of histone H3 lysine residues.	Lysine	146-152	lysine demethylase 1A	Homo sapiens	22-26
21859682-1	2012	Lysine demethylase 1 (LSD1) and Jumonji C domain-containing oxygenase D2C (JMJD2C) participate in regulating the methylation status of histone H3 lysine residues.	Lysine	146-152	lysine demethylase 4C	Homo sapiens	32-73
21859682-1	2012	Lysine demethylase 1 (LSD1) and Jumonji C domain-containing oxygenase D2C (JMJD2C) participate in regulating the methylation status of histone H3 lysine residues.	Lysine	146-152	lysine demethylase 4C	Homo sapiens	75-81
22013045-3	2012	By using glutathione S-transferase (GST) pulldowns, we identified an essential role of lysine 343 in VP16, mutation of which to a neutral amino acid abrogated the interaction between VP1/2 and VP16.	Lysine	87-93	host cell factor C1	Homo sapiens	101-105
22013045-3	2012	By using glutathione S-transferase (GST) pulldowns, we identified an essential role of lysine 343 in VP16, mutation of which to a neutral amino acid abrogated the interaction between VP1/2 and VP16.	Lysine	87-93	host cell factor C1	Homo sapiens	193-197
21870098-1	2012	The recessive mutant allele of the opaque2 gene (o2) alters the endosperm protein pattern and increases the kernel lysine content of maize (Zea mays L.).	Lysine	115-121	regulatory protein opaque-2	Zea mays	35-42
21870098-1	2012	The recessive mutant allele of the opaque2 gene (o2) alters the endosperm protein pattern and increases the kernel lysine content of maize (Zea mays L.).	Lysine	115-121	regulatory protein opaque-2	Zea mays	49-51
21870098-4	2012	Kernel lysine content increased significantly in most of o2 NILs lines relative to normal elite inbreds, but remained unchanged in the genetic backgrounds Dan598o2 and Liao2345o2.	Lysine	7-13	regulatory protein opaque-2	Zea mays	57-59
22389628-4	2012	In response to retinoic acid, CBP/p300 acetylates p53 at lysine 373, which leads to dissociation from E3-ubiquitin ligases HDM2 and TRIM24.	Lysine	57-63	MDM2 proto-oncogene	Homo sapiens	123-127
22389628-4	2012	In response to retinoic acid, CBP/p300 acetylates p53 at lysine 373, which leads to dissociation from E3-ubiquitin ligases HDM2 and TRIM24.	Lysine	57-63	tripartite motif containing 24	Homo sapiens	132-138
22396658-7	2012	Finally, we found that defects in ASF1-RTT109-dependent acetylation of histone H3 lysine residue 56 (H3K56) resulted in increased accumulation of both GCRs and whole-chromosome duplications, and resulted in aneuploidy that tended to occur simultaneously with GCRs.	Lysine	82-88	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	34-38
23226341-3	2012	FOG-2 SUMOylation occurs at four lysine residues (K324, 471, 915, 955) [corrected].	Lysine	33-39	zinc finger protein, FOG family member 2	Homo sapiens	0-5
23227171-0	2012	A single lys residue on the first intracellular loop modulates the endoplasmic reticulum export and cell-surface expression of alpha2A-adrenergic receptor.	Lysine	9-12	adrenoceptor alpha 2A	Homo sapiens	127-154
23227171-8	2012	These data provide the first evidence indicating an important function for a single Lys residue on the ICL1 in the ER export and cell-surface expression of alpha(2A)-AR.	Lysine	84-87	adrenoceptor alpha 2A	Homo sapiens	156-168
23056207-2	2012	In prostate cancer, aggressive cases over-express Tip60 which functions as an androgen receptor co-activator via direct acetylation of lysine residues within the KLKK motif of the receptor hinge region.	Lysine	135-141	lysine acetyltransferase 5	Homo sapiens	50-55
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Lysine	15-22	RB transcriptional corepressor like 2	Mus musculus	77-81
22848639-9	2012	Microinjection of L-364,718, LY-288,513 or CCK-8 to saline pretreated rats produced neither a conditioned preference nor aversion, and the induction of CPA by CCK-8 itself after morphine pretreatments was not significant.	Lysine	29-31	cholecystokinin	Rattus norvegicus	159-162
22860050-7	2012	We identified p65 lysines (K) 122 and 123 as target residues mediating the CCTeta-driven termination of NF-kappaB-dependent transcription.	Lysine	18-25	chaperonin containing TCP1 subunit 7	Homo sapiens	75-81
22539995-7	2012	PIAS1 promoted SUMO-1 modification of GATA4 on lysine 366.	Lysine	47-53	GATA binding protein 4	Homo sapiens	38-43
22457824-11	2012	Finally, we have also identified the Lysine residues at the C-terminus of CXCR7 to be essential for receptor cell surface delivery.	Lysine	37-43	atypical chemokine receptor 3	Homo sapiens	74-79
22470428-0	2012	Function of the active site lysine autoacetylation in Tip60 catalysis.	Lysine	28-34	lysine acetyltransferase 5	Homo sapiens	54-59
22470428-2	2012	We report here that Tip60 undergoes autoacetylation at several lysine residues, including a key lysine residue (i.e. Lys-327) in the active site of the MYST domain.	Lysine	63-69	lysine acetyltransferase 5	Homo sapiens	20-25
22470428-2	2012	We report here that Tip60 undergoes autoacetylation at several lysine residues, including a key lysine residue (i.e. Lys-327) in the active site of the MYST domain.	Lysine	96-102	lysine acetyltransferase 5	Homo sapiens	20-25
22470428-2	2012	We report here that Tip60 undergoes autoacetylation at several lysine residues, including a key lysine residue (i.e. Lys-327) in the active site of the MYST domain.	Lysine	117-120	lysine acetyltransferase 5	Homo sapiens	20-25
22384255-9	2012	This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.	Lysine	24-30	zinc finger E-box binding homeobox 1	Homo sapiens	46-50
22384255-9	2012	This binding results in lysine acetylation of ZEB1 and a release of ZEB1 suppression on miR-200c/141 transcription.	Lysine	24-30	zinc finger E-box binding homeobox 1	Homo sapiens	68-72
22927815-4	2012	Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs.	Lysine	114-120	interleukin 18	Homo sapiens	46-50
22927815-4	2012	Previous structural and functional studies on IL18 and IL18BPs revealed an essential binding hot spot involving a lysine on IL18 and two aromatic residues on IL18BPs.	Lysine	114-120	interleukin 18	Homo sapiens	55-59
22927815-9	2012	The overall architecture of the YLDV-IL18BP:IL18 complex is similar to that observed in the ECTV-IL18BP:IL18 complex, despite lacking the critical lysine-phenylalanine interaction.	Lysine	147-153	interleukin 18	Homo sapiens	44-48
21911064-6	2012	The purified rat NL1 promoted and enhanced the growth rate (137.07+-9.74 mum/day) of the axon on NL1/PLL (poly-L-lysine)-coated fine lines on the chip compared to those lines that were coated with PLL alone (105.53+-4.53 mum/day).	Lysine	106-119	neuroligin 1	Rattus norvegicus	17-20
22116617-6	2012	Nucleotide sequence analysis of paternal beta3 revealed a single nucleotide exchange (G(1818)T) in exon 11 of the beta3 gene (ITGB3), changing Lys(580) (wild-type) to Asn(580) (Sec(a)).	Lysine	143-146	integrin beta-3	Cricetulus griseus	126-131
22039044-5	2011	This model suggests three residues of CXCR4 (Phe-29, Phe-189, Lys-271) as potential interaction sites.	Lysine	62-65	C-X-C motif chemokine receptor 4	Homo sapiens	38-43
22016387-5	2011	Arp2/3-5 (actin-related protein 2/3 subunit 5) and coronin 1A were polyubiquitinated by GRAIL via Lys-48 and Lys-63 linkages.	Lysine	98-101	ring finger protein 128	Homo sapiens	88-93
22016387-5	2011	Arp2/3-5 (actin-related protein 2/3 subunit 5) and coronin 1A were polyubiquitinated by GRAIL via Lys-48 and Lys-63 linkages.	Lysine	109-112	ring finger protein 128	Homo sapiens	88-93
22044126-4	2011	Using poly-SUMO2 as a model system, a two-enzyme trypsin/chymotrypsin digestion was performed to reduce the size of the isopeptide conjugated to the substrate lysine residue.	Lysine	159-165	small ubiquitin like modifier 2	Homo sapiens	11-16
22047492-1	2011	Well-defined amphiphilic Y-shaped miktoarm star-block copolymers of PEO and PCL were synthesized by ring-opening polymerization of epsilon-caprolactone initiated by a PEO-bound lysine macroinitiator.	Lysine	177-183	PHD finger protein 1	Homo sapiens	76-79
21982920-2	2011	An as yet unidentified PLP-containing aminotransferase is thought to catalyze the formation of alpha-aminoadipate from alpha-ketoadipate in the L-lysine biosynthetic pathway that could be the yeast Aro8 gene product.	Lysine	144-152	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	198-202
21985982-3	2011	To identify possible roles for specific lysine residues in the cytoplasmic tail of the Notch ligand Dll1 a mutational and functional analysis was performed.	Lysine	40-46	delta like canonical Notch ligand 1	Homo sapiens	100-104
21985982-4	2011	Examination of a panel of individual or clustered lysine mutants demonstrated that lysine 613 (K613) in the cytoplasmic tail of Dll1 is a key residue necessary for transcellular activation of Notch signaling.	Lysine	50-56	delta like canonical Notch ligand 1	Homo sapiens	128-132
21985982-4	2011	Examination of a panel of individual or clustered lysine mutants demonstrated that lysine 613 (K613) in the cytoplasmic tail of Dll1 is a key residue necessary for transcellular activation of Notch signaling.	Lysine	83-89	delta like canonical Notch ligand 1	Homo sapiens	128-132
21999391-6	2011	Moreover, we demonstrated that histone H1 from cells expressing recombinant LOX contained isodesmosine and desmosine, indicating specific lysyl-oxidase-dependent lysine modifications.	Lysine	162-168	H1.0 linker histone	Homo sapiens	31-41
21999391-6	2011	Moreover, we demonstrated that histone H1 from cells expressing recombinant LOX contained isodesmosine and desmosine, indicating specific lysyl-oxidase-dependent lysine modifications.	Lysine	162-168	lysyl oxidase	Homo sapiens	76-79
21999391-8	2011	The data are compatible with a decreased positive charge of histone H1, owing to deamination by LOX of its lysine residues.	Lysine	107-113	H1.0 linker histone	Homo sapiens	60-70
21999391-8	2011	The data are compatible with a decreased positive charge of histone H1, owing to deamination by LOX of its lysine residues.	Lysine	107-113	lysyl oxidase	Homo sapiens	96-99
21679053-4	2011	The binding of up to 19 acetaldehydes in CA II is probably attributable to the high number of lysine residues (n = 24) located mainly on the surface of the enzyme molecule.	Lysine	94-100	carbonic anhydrase 2	Homo sapiens	41-46
21947282-4	2011	In mass spectrometry analysis, 12 new acetylated lysine sites were identified in DNMT1.	Lysine	49-55	DNA methyltransferase 1	Homo sapiens	81-86
21947282-6	2011	Interestingly, deacetylation of different lysines on DNMT1 has different effects on the functions of DNMT1.	Lysine	42-49	DNA methyltransferase 1	Homo sapiens	53-58
21947282-6	2011	Interestingly, deacetylation of different lysines on DNMT1 has different effects on the functions of DNMT1.	Lysine	42-49	DNA methyltransferase 1	Homo sapiens	101-106
21947282-7	2011	For example, deacetylation of Lys1349 and Lys1415 in the catalytic domain of DNMT1 enhances DNMT1"s methyltransferase activity, while deacetylation of lysine residues in the GK linker decreases DNMT1"s methyltransferase-independent transcriptional repression function.	Lysine	151-157	DNA methyltransferase 1	Homo sapiens	77-82
21947282-8	2011	Furthermore, deacetylation of all identified acetylated lysine sites in DNMT1 abrogates its binding to SIRT1 and impairs its capability to regulate cell cycle G(2)/M transition.	Lysine	56-62	DNA methyltransferase 1	Homo sapiens	72-77
21947282-8	2011	Furthermore, deacetylation of all identified acetylated lysine sites in DNMT1 abrogates its binding to SIRT1 and impairs its capability to regulate cell cycle G(2)/M transition.	Lysine	56-62	sirtuin 1	Homo sapiens	103-108
22112449-7	2011	Recent peptide mapping for recombinant AtMC4 (also called Metacaspase-2d) followed by site-specific mutagenesis studies have revealed multiple potential self-cleavage sites with the identification of a conserved lysine residue (Lys-225) as the key position for enzyme function both in vitro and in vivo.	Lysine	212-218	metacaspase 4	Arabidopsis thaliana	39-44
22112449-7	2011	Recent peptide mapping for recombinant AtMC4 (also called Metacaspase-2d) followed by site-specific mutagenesis studies have revealed multiple potential self-cleavage sites with the identification of a conserved lysine residue (Lys-225) as the key position for enzyme function both in vitro and in vivo.	Lysine	228-231	metacaspase 4	Arabidopsis thaliana	39-44
22131404-4	2011	Our studies reveal that SIRT1 also offers protection against polyQ-expanded AR by deacetylating the AR at lysines 630/632/633.	Lysine	106-113	sirtuin 1	Homo sapiens	24-29
22007908-6	2011	Previous studies showed that the stability of endogenous DNMT1 protein is regulated by lysine methylation through histone lysine methyltransferase Set7 and lysine-specific demethylase 1 (LSD1), with the methylated DNMT1 being the target for proteasomal degradation.	Lysine	87-93	DNA methyltransferase 1	Homo sapiens	57-62
21922608-5	2011	Recruitment of Nurr1, a transcription factor crucial for midbrain DA neuron development, to the promoter of TH gene was enhanced by depolarization, along with increases of histone 3 acetylation (H3Ac) and trimethylation of histone3 on lysine 4 (H3K4m3), and decreases of H3K9m3 and H3K27m3 in the consensus Nurr1 binding regions of TH promoter.	Lysine	235-241	nuclear receptor subfamily 4 group A member 2	Homo sapiens	15-20
21880731-6	2011	The binding specificity was determined primarily through the recognition of arginine 2 and lysine 4 of the unH3 by conserved aspartic acids of PHD1 and of threonine 6 of the unH3 by a conserved asparagine.	Lysine	91-97	Phd1p	Saccharomyces cerevisiae S288C	143-147
21415707-1	2011	Global profiling of histone changes in some human cancers demonstrated that loss of histone H4 acetylation at lysine16 (H4KA16) and trimethylation at lysine 20 (H4KM20) was a common hallmark of cancer.	Lysine	110-116	H4 clustered histone 9	Homo sapiens	84-94
21987678-8	2011	Subsequently, we investigated our entire cohort of families with autosomal recessive retinitis pigmentosa and identified 4 additional families with linkage to chromosome 6p, all of them harboring a single base pair substitution in TULP1 that results in lysine to arginine substitution (p.K489R).	Lysine	253-259	TUB like protein 1	Homo sapiens	231-236
22028627-0	2011	Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination.	Lysine	67-73	PR domain containing 9	Mus musculus	6-11
22028627-4	2011	Here, using transgenic mice, we show that the sole modification of PRDM9 zinc fingers leads to changes in hotspot activity, histone H3 lysine 4 trimethylation (H3K4me3) levels, and chromosome-wide distribution of COs.	Lysine	135-141	PR domain containing 9	Mus musculus	67-72
21852201-3	2011	Target genes repressed by Msx1 display an Msx1-dependent enrichment of Polycomb-directed trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	107-113	msh homeobox 1	Homo sapiens	26-30
21852201-3	2011	Target genes repressed by Msx1 display an Msx1-dependent enrichment of Polycomb-directed trimethylation of lysine 27 on histone H3 (H3K27me3).	Lysine	107-113	msh homeobox 1	Homo sapiens	42-46
21775440-2	2011	We report herein by two-dimensional and three-dimensional NMR experiments of the sensor domain of BlaR1 in solution and by determination of an x-ray structure for the apo protein that Lys-392 of the antibiotic-binding site is posttranslationally modified by N(zeta)-carboxylation.	Lysine	184-187	Beta-lactamase regulatory sensor-transducer BlaR1	Staphylococcus aureus	98-103
21768087-5	2011	The E3 ubiquitin ligases c-Cbl and to a lesser extent Cbl-b facilitated at least partly Lys-48-linked polyubiquitination of autophosphorylated Flt3-ITD when coexpressed in 293T cells.	Lysine	88-91	FMS-like tyrosine kinase 3	Mus musculus	143-147
21841312-3	2011	Here, we show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys)(UUU) and that it is required for the accurate translation of AAA and AAG codons.	Lysine	143-146	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	19-25
21812971-4	2011	RESULTS: Using array-based chromatin immunoprecipitation, we identified 293 genomic loci that are associated with both CTCF and histone H3 trimethylated at lysine 9 (H3K9me3).	Lysine	156-162	CCCTC-binding factor	Homo sapiens	119-123
21646424-0	2011	Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter.	Lysine	11-17	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	84-88
21670155-3	2011	Here we showed that hypoxia also drives epigenetic modification of the BRCA1 promoter, with decreased H3K4 methylation as a key repressive modification produced by the lysine-specific histone demethylase LSD1.	Lysine	168-174	lysine demethylase 1A	Homo sapiens	204-208
21606491-2	2011	Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.	Lysine	97-100	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	54-60
21606491-4	2011	Here, we examined the mechanism of Lys-290 acetylation and found that Rtt109 catalyzes intramolecular autoacetylation of Lys-290 ~200-times slower than H3 acetylation.	Lysine	35-38	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	70-76
21606491-4	2011	Here, we examined the mechanism of Lys-290 acetylation and found that Rtt109 catalyzes intramolecular autoacetylation of Lys-290 ~200-times slower than H3 acetylation.	Lysine	121-124	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	70-76
21606491-7	2011	To dissect the mechanism of activation, biochemical, and kinetic analyses were performed with Lys-290 variants of the Rtt109-Vps75 complex.	Lysine	94-97	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	118-124
21602277-5	2011	Alanine substitution scanning mutagenesis of 20 Zn(2+)-interacting candidate residues in the outer pore region of the hTRPM2 channel showed that mutation of Lys(952) in the extracellular end of the fifth transmembrane segment and Asp(1002) in the large turret strongly attenuated or abolished Zn(2+) inactivation, and mutation of several other residues dramatically changed the inactivation kinetics.	Lysine	157-160	transient receptor potential cation channel subfamily M member 2	Homo sapiens	118-124
21302115-11	2011	Molecular analysis revealed a novel missense mutation 825 G C predicting 275 Lys Asn causing G6PD Bangkok.	Lysine	77-80	glucose-6-phosphate dehydrogenase	Homo sapiens	93-97
21652636-7	2011	Moreover, SUMOylation of pVHL at lysine 171 might modulate its function as a cytokinesis regulator.	Lysine	33-39	von Hippel-Lindau tumor suppressor	Mus musculus	25-29
21367571-1	2011	We have investigated whether Gcn5, a histone acetyltransferase (HAT), is involved in ethanol-induced acetylation of histone H3 at lysine 9 (H3AcK9) and has any effect on the gene expression.	Lysine	130-136	lysine acetyltransferase 2A	Homo sapiens	29-33
21367571-12	2011	This report demonstrates for the first time that (1) GCN5 differentially affects expression of multiple genes, (2) ethanol-induced histone H3-lysine 9 acetylation is mediated via GCN5, and (3) GCN5 is involved in ethanol-induced expression of the putative choline transporter SLC44A2.	Lysine	142-148	lysine acetyltransferase 2A	Homo sapiens	53-57
21367571-12	2011	This report demonstrates for the first time that (1) GCN5 differentially affects expression of multiple genes, (2) ethanol-induced histone H3-lysine 9 acetylation is mediated via GCN5, and (3) GCN5 is involved in ethanol-induced expression of the putative choline transporter SLC44A2.	Lysine	142-148	lysine acetyltransferase 2A	Homo sapiens	179-183
21367571-12	2011	This report demonstrates for the first time that (1) GCN5 differentially affects expression of multiple genes, (2) ethanol-induced histone H3-lysine 9 acetylation is mediated via GCN5, and (3) GCN5 is involved in ethanol-induced expression of the putative choline transporter SLC44A2.	Lysine	142-148	lysine acetyltransferase 2A	Homo sapiens	179-183
21390047-6	2011	Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P&lt;0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009).	Lysine	290-293	ERCC excision repair 5, endonuclease	Homo sapiens	65-70
21390047-6	2011	Importantly, adjusted Cox regression analysis not only confirmed ERCC5 1104 His/His as an independent prognostic factor (multivariate HR=4.5; P&lt;0.001), but also revealed the significant impact of ERCC2 (XPD) 751 Gln/Gln on prognosis, with a 2.2-fold increased HR compared with ERCC2 751 Lys/Lys (P=0.009).	Lysine	294-297	ERCC excision repair 5, endonuclease	Homo sapiens	65-70
21302972-4	2011	We identify a previously ill-defined acetylation site, lysine 20 of histone H4, as a preferred target of three of theses enzymes.	Lysine	55-61	H4 clustered histone 9	Homo sapiens	68-78
21454661-4	2011	In the present study, we provide evidence that the host protein Ku70 interacts with HIV-1 IN and protects it from the Lys(48)-linked polyubiquitination proteasomal pathway.	Lysine	118-121	X-ray repair cross complementing 6	Homo sapiens	64-68
21527249-3	2011	Here we show that SAFB1 is modified by both the SUMO1 and SUMO2/3 family of proteins, on lysine"s K231 and K294.	Lysine	89-95	small ubiquitin like modifier 2	Homo sapiens	58-63
21527717-0	2011	Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.	Lysine	112-115	Histone-lysine N-methyltransferase set-2	Caenorhabditis elegans	53-58
21527717-1	2011	Methylation of histone H3 lysine 4 (H3K4me), a mark associated with gene activation, is mediated by SET1 and the related mixed lineage leukemia (MLL) histone methyltransferases (HMTs) across species.	Lysine	26-32	Histone-lysine N-methyltransferase set-1;SET domain-containing protein	Caenorhabditis elegans	100-104
21388951-9	2011	Src transformation significantly decreased the acetylation levels of histone H4 and increased the trimethylation levels of histone H3 lysine 27 in the cbp promoter.	Lysine	134-140	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	151-154
21411292-0	2011	A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-beta synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth.	Lysine	50-53	immunoglobulin kappa variable 1-13	Homo sapiens	55-58
21411292-1	2011	BACKGROUND: A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18), mimics the bacterial peptidoglycan moiety and acts as a powerful adjuvant that induces cell-mediated immunity.	Lysine	62-65	immunoglobulin kappa variable 1-13	Homo sapiens	67-70
21411292-3	2011	METHODS: Human monocyte-derived DCs (MoDCs) are stimulated with IFN-MDP-Lys (L18) in vitro.	Lysine	72-75	immunoglobulin kappa variable 1-13	Homo sapiens	77-80
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	MDM2 proto-oncogene	Homo sapiens	122-126
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	MDM2 proto-oncogene	Homo sapiens	153-158
21389118-6	2011	Next we demonstrate that lysine residues at position 11 and 12 of beta-arrestin2 are required for the interaction between Mdm2 RING finger mutant H457S (Mdm2(H457S)) and beta-arrestin2, mutation of which prevents Mdm2(H457S)/beta-arrestin2 interaction and subsequent nuclear localization of beta-arrestin2.	Lysine	25-31	MDM2 proto-oncogene	Homo sapiens	213-218
21504832-4	2011	Herein, we report that SirT1 controls global levels of Suv39h1 by increasing its half-life through inhibition of Suv39h1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2.	Lysine	121-127	sirtuin 1	Homo sapiens	23-28
21504832-4	2011	Herein, we report that SirT1 controls global levels of Suv39h1 by increasing its half-life through inhibition of Suv39h1 lysine 87 polyubiquitination by the E3-ubiquitin ligase MDM2.	Lysine	121-127	MDM2 proto-oncogene	Homo sapiens	177-181
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	mitogen-activated protein kinase 8	Mus musculus	148-151
21239472-5	2011	(S)G treatment also attenuated the expression of histone lysine-specific demethylase 1 (LSD1), thereby stimulating lysine methylation of the DNA methylase DNMT1 and triggering its degradation via the ubiquitin-proteasomal pathway.	Lysine	57-63	lysine demethylase 1A	Homo sapiens	88-92
21239472-5	2011	(S)G treatment also attenuated the expression of histone lysine-specific demethylase 1 (LSD1), thereby stimulating lysine methylation of the DNA methylase DNMT1 and triggering its degradation via the ubiquitin-proteasomal pathway.	Lysine	57-63	DNA methyltransferase 1	Homo sapiens	155-160
20885444-0	2011	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.	Lysine	28-34	BCL2-associated X protein	Mus musculus	62-65
20885444-0	2011	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.	Lysine	28-34	BCL2-associated X protein	Mus musculus	90-93
20885444-0	2011	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.	Lysine	28-34	BCL2-associated X protein	Mus musculus	90-93
20885444-4	2011	Mutation of Bax at lysine 128 (BaxK128E) abrogated its effects on Kv1.3 and the induction of apoptotic changes in mitochondria.	Lysine	19-25	BCL2-associated X protein	Mus musculus	12-15
21098725-2	2011	The IL-22-induced effects are mediated by STAT3, whose activity is proportional to acetylation in lysine (Lys)685 and phosphorylation in tyrosine (Tyr)705.	Lysine	98-104	interleukin 22	Homo sapiens	4-9
21098725-2	2011	The IL-22-induced effects are mediated by STAT3, whose activity is proportional to acetylation in lysine (Lys)685 and phosphorylation in tyrosine (Tyr)705.	Lysine	106-109	interleukin 22	Homo sapiens	4-9
21098725-3	2011	Lys 685 acetylation of STAT3 is inhibited by sirtuin (SIRT)1, a class III deacetylase promoting keratinocyte differentiation.	Lysine	0-3	sirtuin 1	Homo sapiens	54-60
21057092-13	2011	2, linear effects on ADG (713, 750, 800, 796, and 785 g/d; P = 0.05) and G:F (P = 0.07) were observed with increasing SID Val:Lys, characterized by improvements to a ratio of 65% and a plateau thereafter.	Lysine	126-129	ADG	Sus scrofa	21-24
21057092-15	2011	3, quadratic improvements in ADG (600, 629, 652, 641, 630, and 642 g/d; P = 0.08) and G:F (P = 0.07) were observed with increasing SID Val:Lys, as performance increased to a ratio of 65% but no further improvement to a ratio of 80%.	Lysine	139-142	ADG	Sus scrofa	29-32
21057092-21	2011	With single-slope broken-line methodology, the minimum ratio estimate was 64 and 65% SID Val:Lys for ADG and G:F, respectively.	Lysine	93-96	ADG	Sus scrofa	101-104
21159881-8	2011	vGPCR expression also induced TAK1 phosphorylation and lysine 63-linked polyubiquitination, the two markers of the kinase"s activation.	Lysine	55-61	K14	Human gammaherpesvirus 8	0-5
21177250-0	2011	HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity.	Lysine	27-33	major histocompatibility complex, class I, C	Homo sapiens	57-75
21146519-10	2011	In addition, we found that the Lysine Specific Demethylase 1 gene (lsd1) was important for the proper cell type-specific development of wing patterning.	Lysine	31-37	Lipid storage droplet-1	Drosophila melanogaster	67-71
21098018-2	2011	The Ube2g2-specific role is the assembly of Lys-48-linked polyubiquitin chains, which constitutes a signal for proteasomal degradation when attached to a substrate protein.	Lysine	44-47	ubiquitin conjugating enzyme E2 G2	Homo sapiens	4-10
21098018-5	2011	The binding of Ube2g2 to Lys-48- and Lys-63-linked diubiquitin is primarily driven by interactions with individual ubiquitin subunits, with a clear preference for the subunit containing the free Lys-48 or Lys-63 side chain (i.e. the distal subunit).	Lysine	25-28	ubiquitin conjugating enzyme E2 G2	Homo sapiens	15-21
21098018-5	2011	The binding of Ube2g2 to Lys-48- and Lys-63-linked diubiquitin is primarily driven by interactions with individual ubiquitin subunits, with a clear preference for the subunit containing the free Lys-48 or Lys-63 side chain (i.e. the distal subunit).	Lysine	37-40	ubiquitin conjugating enzyme E2 G2	Homo sapiens	15-21
21098018-5	2011	The binding of Ube2g2 to Lys-48- and Lys-63-linked diubiquitin is primarily driven by interactions with individual ubiquitin subunits, with a clear preference for the subunit containing the free Lys-48 or Lys-63 side chain (i.e. the distal subunit).	Lysine	37-40	ubiquitin conjugating enzyme E2 G2	Homo sapiens	15-21
21098018-5	2011	The binding of Ube2g2 to Lys-48- and Lys-63-linked diubiquitin is primarily driven by interactions with individual ubiquitin subunits, with a clear preference for the subunit containing the free Lys-48 or Lys-63 side chain (i.e. the distal subunit).	Lysine	37-40	ubiquitin conjugating enzyme E2 G2	Homo sapiens	15-21
21098018-8	2011	As such, these results suggest that Lys-48-linked polyubiquitin chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys-48 side chain can be positioned properly for chain elongation regardless of chain length.	Lysine	36-39	ubiquitin conjugating enzyme E2 G2	Homo sapiens	117-123
21098018-8	2011	As such, these results suggest that Lys-48-linked polyubiquitin chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys-48 side chain can be positioned properly for chain elongation regardless of chain length.	Lysine	187-190	ubiquitin conjugating enzyme E2 G2	Homo sapiens	117-123
21184144-10	2011	Meanwhile, the NDRG1 coding region showed much higher histone H3 lysine 4 methylation in SW480.	Lysine	65-71	N-myc downstream regulated 1	Homo sapiens	15-20
21245294-4	2011	This is caused by transcriptional induction of the KDM6A and KDM6B histone 3 lysine 27-specific demethylases.	Lysine	77-83	lysine demethylase 6B	Homo sapiens	61-66
21304913-0	2011	Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.	Lysine	0-6	RAD1 checkpoint DNA exonuclease	Mus musculus	22-26
21304913-1	2011	Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18.	Lysine	65-71	proliferating cell nuclear antigen	Mus musculus	57-61
21304913-1	2011	Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164)) is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18.	Lysine	65-71	proliferating cell nuclear antigen	Mus musculus	85-89
21047797-2	2011	They are evolutionarily related to the Drosophila HP1 (dHP1) and Pc (dPc) proteins that are key components of chromatin-associated complexes capable of recognizing repressive marks such as trimethylated Lys-9 and Lys-27, respectively, on histone H3.	Lysine	203-206	Heterochromatin Protein 1c	Drosophila melanogaster	55-59
22312332-6	2011	Molecular dynamics simulations indicate that the mCD4-peptide stably interacts with gp120 via an intermolecular beta-sheet, while an important salt-bridge formed by a C-terminal lysine is lost.	Lysine	178-184	CD4 antigen	Mus musculus	49-53
21106372-0	2011	Control of lysyl oxidase activity through site-specific deuteration of lysine.	Lysine	71-77	lysyl oxidase	Homo sapiens	11-24
21106372-5	2011	Lys is an essential nutrient, so dietary ingestion of D(2)Lys and its incorporation via normal Lys turnover suggests new approaches to mitigating LOX-associated pathologies.	Lysine	0-3	lysyl oxidase	Homo sapiens	146-149
21106372-5	2011	Lys is an essential nutrient, so dietary ingestion of D(2)Lys and its incorporation via normal Lys turnover suggests new approaches to mitigating LOX-associated pathologies.	Lysine	58-61	lysyl oxidase	Homo sapiens	146-149
20837137-8	2011	Reconstitution of TAK1-deficient mouse embryo fibroblast cells with TAK1 wild-type, K158R mutant, or K34R mutant reveals that TAK1 lysine 158 residue is required for TGF-beta-induced IKK, p38 and JNK activation.	Lysine	131-137	mitogen-activated protein kinase 8	Mus musculus	196-199
22096030-3	2011	Two key enzymes that regulate irreversible steps in these two processes are pyruvate kinase (PK) and phosphoenolpyruvate carboxy kinase (PEPCK), which catalyze the last and first step of glycolysis and gluconeogenesis, respectively, and are both regulated by lysine acetylation.	Lysine	259-265	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	101-135
22096030-3	2011	Two key enzymes that regulate irreversible steps in these two processes are pyruvate kinase (PK) and phosphoenolpyruvate carboxy kinase (PEPCK), which catalyze the last and first step of glycolysis and gluconeogenesis, respectively, and are both regulated by lysine acetylation.	Lysine	259-265	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	137-142
21446190-1	2011	The substitution of lysine for alanine (K232A) in the acyl-CoA-diacylglycerol acyltransferase, which is encoded by the DGAT1 gene, was tested for the significance for breeding evaluation of stud bulls of the holsteinized Black-and-White breed.	Lysine	20-26	diacylglycerol O-acyltransferase 1	Bos taurus	119-124
21647302-5	2011	On the contrary, the acetylation of Lys-81 in the mutant K2/A2 enhanced the bending potential of HMGB1 C. Regarding the ability of HMGB1 to specifically bind bent DNA, the individual mutations of either K2 or K81 as well as the double mutation of both residues to alanine were found to completely abolish binding of truncated tail-less HMGB1 to cisplatin-modified DNA.	Lysine	36-39	keratin 81	Homo sapiens	209-212
21109933-2	2011	CYLD is a deubiquitinating enzyme acting as a negative regulator of the nuclear factor kappaB (NF-kappaB) signaling pathway by removing lysine-63-linked polyubiquitin chains from NF-kappaB activating proteins.	Lysine	136-142	CYLD lysine 63 deubiquitinase	Homo sapiens	0-4
20306300-1	2011	The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin.	Lysine	137-143	lysyl oxidase	Homo sapiens	4-17
20306300-1	2011	The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin.	Lysine	137-143	lysyl oxidase	Homo sapiens	26-29
20306300-1	2011	The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin.	Lysine	137-143	elastin	Homo sapiens	186-193
21647297-3	2011	SUMOylation of Nhp2 and endogenous Nop58 was confirmed using a combination of in vitro and cell-based assays and the modified lysines identified by site-directed mutagenesis.	Lysine	126-133	NHP2 ribonucleoprotein	Homo sapiens	15-19
21980421-3	2011	Currently, Glu314, Ser346, Lys347 and Lys362 in human c-NADP-ME were changed to the corresponding residues of human m-NAD(P)-ME (Glu, Lys, Tyr and Gln, respectively) or Ascaris suum m-NAD-ME (Ala, Ile, Asp and His, respectively).	Lysine	27-30	malic enzyme 1	Homo sapiens	56-63
22022377-0	2011	Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.	Lysine	93-99	M-phase phosphoprotein 8	Homo sapiens	47-51
21935461-9	2011	We observed hyperacetylation together with trimethylation of Lys-4 at the IL-17 locus in TCF-1(-/-) thymocytes, two epigenetic modifications indicating an open active state of the gene.	Lysine	61-64	interleukin 17A	Mus musculus	74-79
21853124-3	2011	However, this notion has been challenged by data in which a lysine-less mutant of Cdc20 leads to premature anaphase, suggesting that it"s ubiquitination is not required for APC/C activation.	Lysine	60-66	cell division cycle 20	Homo sapiens	82-87
21901142-8	2011	Conversely, mutation of the conserved lysine within the intracellular loop between TM3 and TM4 attenuated NA-Gly-mediated potentiation of alpha(1) GlyRs, without affecting inhibition of alpha(2) and alpha(3).	Lysine	38-44	tropomyosin 3	Homo sapiens	83-86
20841510-3	2010	Both carried a homozygous missense mutation replacing a lysine with an asparagine residue at position 201 (K201N) of STAT1.	Lysine	56-62	signal transducer and activator of transcription 1	Homo sapiens	117-122
20943656-0	2010	Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.	Lysine	141-147	ataxin 3	Homo sapiens	97-105
20943656-3	2010	We identify Lys-117, which resides near the catalytic triad, as the primary site of ubiquitination in wild type and pathogenic ataxin-3.	Lysine	12-15	ataxin 3	Homo sapiens	127-135
20943656-4	2010	Further studies indicate that ubiquitin-dependent activation of ataxin-3 at Lys-117 is important for its ability to reduce high molecular weight ubiquitinated species in cells.	Lysine	76-79	ataxin 3	Homo sapiens	64-72
20943656-5	2010	Ubiquitination at Lys-117 also facilitates the ability of ataxin-3 to induce aggresome formation in cells.	Lysine	18-21	ataxin 3	Homo sapiens	58-66
20943656-6	2010	Finally, structure-function studies support a model of activation whereby ubiquitination at Lys-117 enhances ataxin-3 activity independent of the known ubiquitin-binding sites in ataxin-3, most likely through a direct conformational change in or near the catalytic domain.	Lysine	92-95	ataxin 3	Homo sapiens	109-117
21109197-7	2010	Molecular dynamics simulations show that in silico deacetylation of these three lysines causes conformational changes of HMGCS2 near the active site.	Lysine	80-87	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	121-127
20858899-8	2010	In vitro ubiquitination assays followed by analysis using mass spectroscopy revealed that Smurf2 specifically ubiquitinylated Lys(505) of Axin and that the Axin(K505R) mutant resisted degradation.	Lysine	126-129	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	90-96
20858899-8	2010	In vitro ubiquitination assays followed by analysis using mass spectroscopy revealed that Smurf2 specifically ubiquitinylated Lys(505) of Axin and that the Axin(K505R) mutant resisted degradation.	Lysine	126-129	axin 1	Homo sapiens	138-142
21124938-0	2010	Autoacetylation of the Ralstonia solanacearum effector PopP2 targets a lysine residue essential for RRS1-R-mediated immunity in Arabidopsis.	Lysine	71-77	Disease resistance protein (TIR-NBS-LRR class)	Arabidopsis thaliana	100-104
21124938-10	2010	Indeed, mutation of this lysine in PopP2 abolishes RRS1-R-mediated immunity.	Lysine	25-31	Disease resistance protein (TIR-NBS-LRR class)	Arabidopsis thaliana	51-55
20817729-6	2010	Tandem mass spectrometry and mutagenesis studies revealed that SREBP-1c is acetylated by p300 at Lys-289 and Lys-309.	Lysine	97-100	E1A binding protein p300	Mus musculus	89-93
21060864-3	2010	Methylation of histone H3 at lysine 36 by the Set2 methyltransferase is thought to mediate the recruitment of Rpd3S.	Lysine	29-35	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	46-50
20668333-1	2010	Rtt109p, a histone acetyltransferase, associates with active genes and acetylates lysine 56 on histone H3 in Saccharomyces cerevisiae.	Lysine	82-88	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	0-7
20668333-3	2010	Here, we show that Rtt109p promotes the eviction of histone H3 from a fast inducible yeast gene, GAL1, following transcriptional initiation via histone H3 Lys(56) acetylation.	Lysine	155-158	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	19-26
20668333-5	2010	Intriguingly, we also find that the deposition of histone H2B on preexisting non-acetylated histone H3 Lys(56) at GAL1 in Deltartt109 is significantly increased independently of histone H3 deposition immediately following transcriptional termination subsequent to a short induction.	Lysine	103-106	histone H2B	Saccharomyces cerevisiae S288C	50-61
20518739-4	2010	The values of association equilibrium constants determined with bovine beta-trypsin ranging 10(8) - 10(9) M(-1) with the highest (3.90 x 10(9) M(-1)) determined for analogue containing Lys and Dap in aforementioned positions.	Lysine	185-188	death associated protein	Bos taurus	193-196
20669242-8	2010	Interestingly, human Pcl orthologs exhibit a complete aromatic cage, suggesting that they may recognize methylated lysines.	Lysine	115-122	PHD finger protein 1	Homo sapiens	21-24
20797861-3	2010	Acetylation of Smc3 by Eco1 at two evolutionarily conserved lysine residues promotes cohesion establishment during S phase in budding yeast and humans [14-16].	Lysine	60-66	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	15-19
20797861-3	2010	Acetylation of Smc3 by Eco1 at two evolutionarily conserved lysine residues promotes cohesion establishment during S phase in budding yeast and humans [14-16].	Lysine	60-66	Eco1p	Saccharomyces cerevisiae S288C	23-27
20718938-6	2010	Here, we report that Maf proteins are also post-translationally modified by small ubiquitin-like modifier (SUMO) proteins at a conserved lysine residue in the amino-terminal transactivator domain.	Lysine	137-143	MAF bZIP transcription factor	Gallus gallus	21-24
20645434-3	2010	Our recent studies with GAL analogs suggested that an introduction of lipoamino acids in the context of oligo-Lys residues (lipidization-cationization motif) significantly increases their penetration into the brain, yielding potent antiepileptic compounds.	Lysine	110-113	galanin and GMAP prepropeptide	Homo sapiens	24-27
20606006-8	2010	In addition, we identify five lysine residues (K180, K182, K183, K188, and K193) immediately downstream of the Xic1 PIP box and within the second Cdt2 binding domain as critical sites for Xic1 ubiquitination.	Lysine	30-36	denticleless E3 ubiquitin protein ligase homolog S homeolog	Xenopus laevis	146-150
20551307-8	2010	Analysis of structural models of CFTR identified that although Lys(584) interacts with residue Leu(581) in human CFTR Glu(584) interacts with Phe(581) in mouse CFTR.	Lysine	63-66	cystic fibrosis transmembrane conductance regulator	Mus musculus	113-117
20551327-4	2010	Immunopurification and N-terminal sequencing of this cell-retained fragment and detailed mutagenesis, show that proteolytic processing of CDCP1 occurs at two sites, Arg-368 and Lys-369.	Lysine	177-180	CUB domain containing protein 1	Homo sapiens	138-143
20402667-4	2010	Further, USP44 undergoes both lysine 48- and lysine 63-linked polyubiquitination.	Lysine	30-36	ubiquitin specific peptidase 44	Mus musculus	9-14
20402667-4	2010	Further, USP44 undergoes both lysine 48- and lysine 63-linked polyubiquitination.	Lysine	45-51	ubiquitin specific peptidase 44	Mus musculus	9-14
20568780-4	2010	These compounds induce increases in methylation at the histone 3 lysine 4 (H3K4) chromatin mark, a specific target of LSD1, in Calu-6 lung carcinoma cells.	Lysine	65-71	lysine demethylase 1A	Homo sapiens	118-122
20615959-0	2010	Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.	Lysine	51-57	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Mus musculus	20-24
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Lysine	30-36	MDM2 proto-oncogene	Homo sapiens	118-122
20408817-4	2010	In the present study we show that XBP1s, the active spliced form of XBP1 protein, is SUMOylated, mainly by PIAS2 [protein inhibitor of activated STAT (signal transducer and activator of transcription) 2] at two lysine residues located in the C-terminal transactivation domain.	Lysine	211-217	signal transducer and activator of transcription 2	Homo sapiens	151-202
20571979-1	2010	LY-2140023 is a methionine amide prodrug of the orthosteric metabotropic glutamate receptor (mGluR)2/3 agonist LY-404039, being developed by Eli Lilly &amp; Co, for the potential oral treatment of schizophrenia.	Lysine	0-3	glutamate metabotropic receptor 2	Homo sapiens	60-100
20189264-2	2010	Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	155-161	lysine demethylase 1A	Homo sapiens	0-29
20189264-2	2010	Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	155-161	lysine demethylase 1A	Homo sapiens	31-35
20189264-2	2010	Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	175-181	lysine demethylase 1A	Homo sapiens	0-29
20189264-2	2010	Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).	Lysine	175-181	lysine demethylase 1A	Homo sapiens	31-35
20203086-5	2010	Mutation of the lysines abolishes SUMOylation of MAML1 and strongly increases MAML1-activated transcription in cell culture assays.	Lysine	16-23	mastermind like transcriptional coactivator 1	Homo sapiens	49-54
20203086-5	2010	Mutation of the lysines abolishes SUMOylation of MAML1 and strongly increases MAML1-activated transcription in cell culture assays.	Lysine	16-23	mastermind like transcriptional coactivator 1	Homo sapiens	78-83
20385540-6	2010	This study showed that ICI 182,780 is able to increase CDH3 promoter activity, inducing high levels of the active chromatin mark H3 lysine 4 dimethylation.	Lysine	132-138	cadherin 3	Homo sapiens	55-59
20473554-6	2010	We also found that free lysine contributed partially to the increased lysine in o2 kernels while protein-bound lysine was mainly responsible for the increased lysine in transgenic zein reduction (TZR) kernels.	Lysine	70-76	regulatory protein opaque-2	Zea mays	80-82
20473554-6	2010	We also found that free lysine contributed partially to the increased lysine in o2 kernels while protein-bound lysine was mainly responsible for the increased lysine in transgenic zein reduction (TZR) kernels.	Lysine	70-76	regulatory protein opaque-2	Zea mays	80-82
20473554-6	2010	We also found that free lysine contributed partially to the increased lysine in o2 kernels while protein-bound lysine was mainly responsible for the increased lysine in transgenic zein reduction (TZR) kernels.	Lysine	70-76	regulatory protein opaque-2	Zea mays	80-82
20347313-1	2010	The tumor suppressor CYLD is a deubiquitylating enzyme that negatively regulates different signaling pathways by removing lysine 63-linked polyubiquitin chains from several specific substrates.	Lysine	122-128	CYLD lysine 63 deubiquitinase	Homo sapiens	21-25
20368332-1	2010	E1 ubiquitin-activating enzymes (UBAs) are large multidomain proteins that catalyze formation of a thioester bond between the terminal carboxylate of a ubiquitin or ubiquitin-like modifier (UBL) and a conserved cysteine in an E2 protein, producing reactive ubiquityl units for subsequent ligation to substrate lysines.	Lysine	310-317	ubiquitin conjugating enzyme E2 B	Homo sapiens	226-236
20457133-0	2010	Homology models for domains 21-23 of human tropoelastin shed light on lysine crosslinking.	Lysine	70-76	elastin	Homo sapiens	43-55
20353940-9	2010	Intriguingly, Cdc34 Tyr(210) was required for the transfer of the donor ubiquitin to a receptor lysine on either IkappaBalpha or a ubiquitin in a manner that depended on the neddylated RING sub-complex of the SCF.	Lysine	96-102	KIT ligand	Homo sapiens	209-212
20698772-8	2010	In addition, chromatin immunoprecipitation assay revealed that histone H3 is highly acetylated, and H3 lysine (K) 4 is hypermethylated at the Nanog locus and the Oct-4 locus in hESCs grown on hAECs.	Lysine	103-109	Nanog homeobox	Homo sapiens	142-147
20363750-0	2010	Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.	Lysine	15-21	MDS1 and EVI1 complex locus	Homo sapiens	86-90
20363750-5	2010	Acetylation at Lys(564), which is adjacent to the CtBP-binding consensus sequence of EVI1, was found to be important for transcriptional activation of GATA2.	Lysine	15-18	MDS1 and EVI1 complex locus	Homo sapiens	85-89
20363750-7	2010	Furthermore, we confirmed that Lys(564) in EVI1 was specifically acetylated in leukemia and primary hematopoietic cells by using an antibody directed against an acetylated Lys(564) EVI1 peptide.	Lysine	31-34	MDS1 and EVI1 complex locus	Homo sapiens	43-47
20363750-7	2010	Furthermore, we confirmed that Lys(564) in EVI1 was specifically acetylated in leukemia and primary hematopoietic cells by using an antibody directed against an acetylated Lys(564) EVI1 peptide.	Lysine	31-34	MDS1 and EVI1 complex locus	Homo sapiens	181-185
20363750-7	2010	Furthermore, we confirmed that Lys(564) in EVI1 was specifically acetylated in leukemia and primary hematopoietic cells by using an antibody directed against an acetylated Lys(564) EVI1 peptide.	Lysine	172-175	MDS1 and EVI1 complex locus	Homo sapiens	43-47
20363750-7	2010	Furthermore, we confirmed that Lys(564) in EVI1 was specifically acetylated in leukemia and primary hematopoietic cells by using an antibody directed against an acetylated Lys(564) EVI1 peptide.	Lysine	172-175	MDS1 and EVI1 complex locus	Homo sapiens	181-185
20363750-9	2010	Thus, acetylation of EVI1 at Lys(564) by P/CAF enhances the DNA binding capacity of EVI1 and thereby contributes to the activation of GATA2.	Lysine	29-32	MDS1 and EVI1 complex locus	Homo sapiens	21-25
20363750-9	2010	Thus, acetylation of EVI1 at Lys(564) by P/CAF enhances the DNA binding capacity of EVI1 and thereby contributes to the activation of GATA2.	Lysine	29-32	MDS1 and EVI1 complex locus	Homo sapiens	84-88
20402481-1	2010	The Saccharomyces cerevisiae high mobility group protein HMO1 has two DNA binding domains, box A and box B, and a lysine-rich C-terminal extension.	Lysine	114-120	Hmo1p	Saccharomyces cerevisiae S288C	57-61
20394361-0	2010	Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.	Lysine	0-6	complement factor H	Homo sapiens	150-158
20016039-3	2010	Based on its homology to other serine/threonine protein kinases, we defined two highly conserved lysines in US3, at position 195 within the ATP-binding pocket and at position 282 within the catalytic loop; altering either residue resulted in kinase-dead mutants, demonstrating that these two residues are critical for the catalytic activity of BoHV-1 US3.	Lysine	97-104	serine/threonine protein kinase US3	Bovine alphaherpesvirus 1	108-111
20016039-3	2010	Based on its homology to other serine/threonine protein kinases, we defined two highly conserved lysines in US3, at position 195 within the ATP-binding pocket and at position 282 within the catalytic loop; altering either residue resulted in kinase-dead mutants, demonstrating that these two residues are critical for the catalytic activity of BoHV-1 US3.	Lysine	97-104	serine/threonine protein kinase US3	Bovine alphaherpesvirus 1	351-354
20160011-4	2010	Abolishing the acetylation of lysine 310 either by the deacetylase SIRT1 or by mutating lysine 310 to arginine enhances methylation.	Lysine	30-36	sirtuin 1	Homo sapiens	67-72
20160011-5	2010	Conversely, enhancing the acetylation of lysine 310 by depleting SIRT1 or by replacing lysine 310 with acetyl-mimetic glutamine inhibits methylation, thereby decreasing ubiquitination, prolonging the stability of chromatin-associated RelA, and enhancing the transcriptional activity of NF-kappaB.	Lysine	41-47	sirtuin 1	Homo sapiens	65-70
20048150-9	2010	Introduction of a lysine residue at the corresponding positions of BMP-2 and BMP-7 allowed for molecular engineering of recombinant BMPs with increased resistance to noggin antagonism.	Lysine	18-24	bone morphogenetic protein 7	Homo sapiens	77-82
20032457-7	2010	Finally, we also show that Abro1, another BRISC subunit, binds directly to Brcc36 and that the Brcc36-Abro1 heterodimer includes a minimal complex with Lys(63)-specific DUB activity.	Lysine	152-155	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	95-101
20467398-7	2010	Radiochemical stability of the a-MSH analogues was improved through the conjugation of metal chelators to the peptide"s N-terminus or lysine residues for radionuclide coordination.	Lysine	134-140	msh homeobox 1	Mus musculus	33-36
20071582-3	2010	Upon the recognition of viral RNA, the Lys-172 residue of RIG-I undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction.	Lysine	39-42	DExD/H-box helicase 58	Homo sapiens	58-63
20086098-7	2010	The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro.	Lysine	82-88	Cbl proto-oncogene like 2	Homo sapiens	27-46
20026581-5	2010	Investigating further links with heterochromatin, we could show that Np95 preferentially binds histone H3 N-terminal tails with trimethylated (H3K9me3) but not acetylated lysine 9 via a tandem Tudor domain.	Lysine	171-177	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	69-73
20354225-2	2010	We found that NUAK1 interacts with several myosin phosphatases, including the myosin phosphatase targeting-1 (MYPT1)-protein phosphatase-1beta (PP1beta) complex, through conserved Gly-Ile-Leu-Lys motifs that are direct binding sites for PP1beta.	Lysine	192-195	NUAK family kinase 1	Homo sapiens	14-19
20360974-4	2010	A Jumonji C family histone 3 lysine-27 (H3K27) demethylase, Jmjd3, plays a crucial role in macrophage plasticity and inflammation.	Lysine	29-35	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	60-65
20118233-3	2010	Here, we describe a novel lysine methylation site in p53 that is carried out by two homologous histone methyltransferases, G9a and Glp.	Lysine	26-32	euchromatic histone lysine methyltransferase 2	Homo sapiens	123-126
20118233-4	2010	G9a and Glp specifically methylate p53 at Lys(373), resulting mainly in dimethylation.	Lysine	42-45	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
20064925-9	2010	Moreover, we demonstrated that the dynamic pattern of lysine 27 trimethylation of histone 3 was conferred by the interplay of SUZ12 and JMJD3, both of which were involved in maintaining hESC pluripotency.	Lysine	54-60	lysine demethylase 6B	Homo sapiens	136-141
20300531-5	2010	Here we report that PIASy, a SUMO E3 ligase upregulated in hypoxia, interacts with VHL and induces VHL SUMOylation on lysine residue 171.	Lysine	118-124	protein inhibitor of activated STAT 4	Homo sapiens	20-25
20450724-9	2010	A cross-species alignment of GATA4 encoded protein sequences displayed that the lysine at amino acid residue 329 was completely conserved evolutionarily.	Lysine	80-86	GATA binding protein 4	Homo sapiens	29-34
19935701-8	2010	In addition, lysine 96 residue is essential for ING3 ubiquitination as its mutation to arginine dramatically abrogated ING3 degradation.	Lysine	13-19	inhibitor of growth family member 3	Homo sapiens	48-52
19935701-8	2010	In addition, lysine 96 residue is essential for ING3 ubiquitination as its mutation to arginine dramatically abrogated ING3 degradation.	Lysine	13-19	inhibitor of growth family member 3	Homo sapiens	119-123
20048151-4	2010	The BRD2-BD1 recognizes the H4 tail acetylated at Lys-12 (H4K12ac), whereas the side chain of hypoacetylated Lys-8 of H4 binds at the cavity of the dimer interface of BRD2-BD1.	Lysine	50-53	bromodomain containing 2	Homo sapiens	4-12
20048151-4	2010	The BRD2-BD1 recognizes the H4 tail acetylated at Lys-12 (H4K12ac), whereas the side chain of hypoacetylated Lys-8 of H4 binds at the cavity of the dimer interface of BRD2-BD1.	Lysine	109-112	bromodomain containing 2	Homo sapiens	167-175
20048151-5	2010	From binding studies, we identified the BRD2-BD1 residues that are responsible for recognition of the Lys-12-acetylated H4 tail.	Lysine	102-105	bromodomain containing 2	Homo sapiens	40-48
20042638-3	2010	Lysine-specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated lysine 4 of histone H3 and lysine 9 of histone H3.	Lysine	137-143	lysine demethylase 1A	Homo sapiens	0-29
20042638-3	2010	Lysine-specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated lysine 4 of histone H3 and lysine 9 of histone H3.	Lysine	137-143	lysine demethylase 1A	Homo sapiens	31-35
20042638-3	2010	Lysine-specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated lysine 4 of histone H3 and lysine 9 of histone H3.	Lysine	164-170	lysine demethylase 1A	Homo sapiens	0-29
20042638-3	2010	Lysine-specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated lysine 4 of histone H3 and lysine 9 of histone H3.	Lysine	164-170	lysine demethylase 1A	Homo sapiens	31-35
20160506-7	2010	Tip60"s chromodomain then interacts with histone H3 trimethylated on lysine 9, activating Tip60"s acetyltransferase activity and stimulating the subsequent acetylation and activation of ATM"s kinase activity.	Lysine	69-75	lysine acetyltransferase 5	Homo sapiens	0-5
20160506-7	2010	Tip60"s chromodomain then interacts with histone H3 trimethylated on lysine 9, activating Tip60"s acetyltransferase activity and stimulating the subsequent acetylation and activation of ATM"s kinase activity.	Lysine	69-75	lysine acetyltransferase 5	Homo sapiens	90-95
20077120-8	2010	In XS52 cells, which express TLR2, TLR3, TLR4, and TLR7, but not TLR9, expression of claudin-7 protein was also increased after treatment with ligands of TLR2, TLR4 or TLR7/8, Pam3Cys-Ser-(Lys)4, LPS, or CL097.	Lysine	189-192	toll-like receptor 7	Mus musculus	168-174
20018880-5	2010	CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis.	Lysine	76-83	choline phosphotransferase 1	Homo sapiens	0-4
20018880-5	2010	CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis.	Lysine	76-83	lysophosphatidylcholine acyltransferase 1	Homo sapiens	131-137
20067792-2	2010	The PHF8 active site is highly conserved with those of the FBXL10/11demethylases, which are also selective for the di-/mono-methylated lysine states, but differs from that of the JMJD2 demethylases which are selective for tri-/di-methylated states.	Lysine	135-141	lysine demethylase 4A	Homo sapiens	179-184
20145208-5	2010	The SUMOylation sites of IGF-1R were identified as three evolutionarily conserved lysine residues-Lys(1025), Lys(1100), and Lys(1120)-in the beta subunit of the receptor.	Lysine	82-88	insulin like growth factor 1 receptor	Homo sapiens	25-31
20145208-5	2010	The SUMOylation sites of IGF-1R were identified as three evolutionarily conserved lysine residues-Lys(1025), Lys(1100), and Lys(1120)-in the beta subunit of the receptor.	Lysine	98-101	insulin like growth factor 1 receptor	Homo sapiens	25-31
20145208-5	2010	The SUMOylation sites of IGF-1R were identified as three evolutionarily conserved lysine residues-Lys(1025), Lys(1100), and Lys(1120)-in the beta subunit of the receptor.	Lysine	109-112	insulin like growth factor 1 receptor	Homo sapiens	25-31
20145208-5	2010	The SUMOylation sites of IGF-1R were identified as three evolutionarily conserved lysine residues-Lys(1025), Lys(1100), and Lys(1120)-in the beta subunit of the receptor.	Lysine	109-112	insulin like growth factor 1 receptor	Homo sapiens	25-31
20004207-1	2010	Yeast Saccharomyces cerevisiae MTO2, MTO1, and MSS1 genes encoded highly conserved tRNA modifying enzymes for the biosynthesis of carboxymethylaminomethyl (cmnm)(5)s(2)U(34) in mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln).	Lysine	196-199	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	31-35
20004207-1	2010	Yeast Saccharomyces cerevisiae MTO2, MTO1, and MSS1 genes encoded highly conserved tRNA modifying enzymes for the biosynthesis of carboxymethylaminomethyl (cmnm)(5)s(2)U(34) in mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln).	Lysine	196-199	Mss1p	Saccharomyces cerevisiae S288C	47-51
20004207-8	2010	The synthetic enhancement combinations likely resulted from the completely abolished modification at U(34) of tRNA(Lys), tRNA(Glu), and tRNA(Gln), caused by the combination of eliminating the 2-thiouridylation by the mto2 mutation with the absence of the cmnm(5)U(34) by the mto1 or mss1 mutation.	Lysine	115-118	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	217-221
20004207-8	2010	The synthetic enhancement combinations likely resulted from the completely abolished modification at U(34) of tRNA(Lys), tRNA(Glu), and tRNA(Gln), caused by the combination of eliminating the 2-thiouridylation by the mto2 mutation with the absence of the cmnm(5)U(34) by the mto1 or mss1 mutation.	Lysine	115-118	Mss1p	Saccharomyces cerevisiae S288C	283-287
19883641-6	2010	Of the 230 genes that were differentially regulated after RGC-32 knockdown, a group of genes involved in chromatin assembly were the most significantly regulated in these cells: RGC-32 knockdown induced an increase in acetylation of histones H2B lysine 5 (H2BK5), H2BK15, H3K9, H3K18, and H4K8.	Lysine	246-252	regulator of cell cycle	Homo sapiens	58-64
19883641-6	2010	Of the 230 genes that were differentially regulated after RGC-32 knockdown, a group of genes involved in chromatin assembly were the most significantly regulated in these cells: RGC-32 knockdown induced an increase in acetylation of histones H2B lysine 5 (H2BK5), H2BK15, H3K9, H3K18, and H4K8.	Lysine	246-252	regulator of cell cycle	Homo sapiens	178-184
19717620-2	2010	In this work, we have studied the involvement of the cationic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) in the translocation of the enzyme to the phagosomal cup in human macrophages responding to opsonized zymosan.	Lysine	87-90	phospholipase A2 group IVA	Homo sapiens	73-85
19717620-2	2010	In this work, we have studied the involvement of the cationic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) in the translocation of the enzyme to the phagosomal cup in human macrophages responding to opsonized zymosan.	Lysine	96-99	phospholipase A2 group IVA	Homo sapiens	73-85
19717620-2	2010	In this work, we have studied the involvement of the cationic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) in the translocation of the enzyme to the phagosomal cup in human macrophages responding to opsonized zymosan.	Lysine	96-99	phospholipase A2 group IVA	Homo sapiens	73-85
19717620-2	2010	In this work, we have studied the involvement of the cationic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) in the translocation of the enzyme to the phagosomal cup in human macrophages responding to opsonized zymosan.	Lysine	96-99	phospholipase A2 group IVA	Homo sapiens	73-85
19717620-9	2010	Collectively, these data indicate that the polybasic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) regulates the subcellular localization of the enzyme in intact cells under physiologically relevant conditions.	Lysine	78-81	phospholipase A2 group IVA	Homo sapiens	64-76
19717620-9	2010	Collectively, these data indicate that the polybasic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) regulates the subcellular localization of the enzyme in intact cells under physiologically relevant conditions.	Lysine	87-90	phospholipase A2 group IVA	Homo sapiens	64-76
19717620-9	2010	Collectively, these data indicate that the polybasic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) regulates the subcellular localization of the enzyme in intact cells under physiologically relevant conditions.	Lysine	87-90	phospholipase A2 group IVA	Homo sapiens	64-76
19717620-9	2010	Collectively, these data indicate that the polybasic cluster of cPLA(2)alpha (Lys(488)/Lys(541)/Lys(543)/Lys(544)) regulates the subcellular localization of the enzyme in intact cells under physiologically relevant conditions.	Lysine	87-90	phospholipase A2 group IVA	Homo sapiens	64-76
19881540-2	2010	In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promoters that the DNMT inhibitor, 5-aza-2"-deoxycytidine, induced p15INK4B and E-cadherin expression, and decreased levels of DNA methylation, histone H3 lysine 9 (H3K9) methylation and SUV39H1 associated with p15INK4B and E-cadherin promoters.	Lysine	267-273	DNA methyltransferase 1	Homo sapiens	131-135
20080646-3	2010	Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity.	Lysine	26-32	histone acetyltransferase	Saccharomyces cerevisiae S288C	67-92
20080646-3	2010	Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity.	Lysine	26-32	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	93-99
20010696-5	2010	Analysis of a single-copy gene, SUPPRESSOR OF drm1 drm2 cmt3 (SDC), revealed that mom1 activates SDC with concomitant reduction of di-methylated histone H3 lysine 9 (H3K9me2) at the tandem repeats in the promoter region without changes in siRNA accumulation and cytosine methylation.	Lysine	156-162	ATP-dependent helicase family protein	Arabidopsis thaliana	82-86
20621284-4	2010	Of the covalent chromatin modifications, the acetylation of lysine residues within histone proteins by acetyltransferase enzymes, such as GCN5, is one of the most prevalent and important steps in the regulation of chromatin function.	Lysine	60-66	lysine acetyltransferase 2A	Homo sapiens	138-142
21209387-5	2010	The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining gene expression.	Lysine	15-21	lysine demethylase 6B	Homo sapiens	46-51
19783705-7	2010	1, increasing dietary SID Lys increased (linear, P &lt; 0.01) ADG and G:F, and increasing dietary ME increased (quadratic, P &lt; 0.05) G:F. In Exp.	Lysine	26-29	ADG	Sus scrofa	62-65
19783705-9	2010	2, increasing dietary SID Lys increased (linear, P &lt; 0.01) ADG and G:F. Increasing dietary ME increased (linear, P &lt; 0.01) G:F. Because of the linear responses in this experiment, optimal Lys:Mcal ratio was at least 4.0 g of Lys/Mcal of ME.	Lysine	26-29	ADG	Sus scrofa	62-65
19783705-18	2010	3, there was an ME x Lys:Mcal ratio interaction (P &lt; 0.03) for ADG.	Lysine	21-24	ADG	Sus scrofa	66-69
19783705-19	2010	The greatest ADG was a Lys:Mcal ratio of 3.60 for pigs fed low ME and a ratio of 3.35 for pigs fed high ME.	Lysine	23-26	ADG	Sus scrofa	13-16
19949111-0	2010	Lysine acetylation regulates Bruton"s tyrosine kinase in B cell activation.	Lysine	0-6	Bruton tyrosine kinase	Homo sapiens	29-53
19949111-2	2010	Although Btk has been extensively studied, the role of lysine acetylation in Btk regulation has not been reported.	Lysine	55-61	Bruton tyrosine kinase	Homo sapiens	77-80
19949111-3	2010	In this study, we show that BCR cross-linking induces histone lysine acetylation at the Btk promoter, correlating with marked recruitment of histone acetyltransferase E1A-associated 300-kDa protein (p300) to the locus.	Lysine	62-68	Bruton tyrosine kinase	Homo sapiens	88-91
19949111-6	2010	Interestingly, we found that BCR signaling induces Btk lysine acetylation mediated by p300.	Lysine	55-61	Bruton tyrosine kinase	Homo sapiens	51-54
19949111-7	2010	Moreover, lysine acetylation of Btk promotes its phosphorylation.	Lysine	10-16	Bruton tyrosine kinase	Homo sapiens	32-35
19887647-3	2010	Here we show that ER-alpha proteins with single or double lysine mutations of these motifs (including K303R, a cancer-associated mutant) are resistant to inhibition by BRCA1, even though the mutant ER-alpha proteins retain the ability to bind to BRCA1.	Lysine	58-64	BRCA1 DNA repair associated	Homo sapiens	168-173
19877718-7	2009	Replacement of an Ala in the N-terminal half of the neuromodulin sequence with the Gln in PEP19 accounts for approximately half of the Ca(2+)-independent difference in the stabilities of the two reporter complexes, with the Ca(2+)-independent effect of the Lys replacement accounting for most of the remainder.	Lysine	257-260	Purkinje cell protein 4	Homo sapiens	90-95
19766174-2	2009	The ALAD is controlled by two codominant alleles (ALAD1 and ALAD2), which result in a Asn-Lys substitution at amino acid position 59 of the mature enzyme based on a single nucleotide polymorphism (SNP) (G177C) leading three phenotypes (ALAD1-1, ALAD1-2, and ALAD2-2).	Lysine	90-93	aminolevulinate dehydratase	Homo sapiens	4-8
19799855-3	2009	A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.	Lysine	116-122	chromodomain Y like	Homo sapiens	198-203
19799855-3	2009	A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.	Lysine	161-167	chromodomain Y like	Homo sapiens	198-203
19781040-5	2009	The DGAT1 allele that encode lysine at position 232 was associated with increased 305-day milk fat yield, but with decreased 305-day milk and protein yield, whereas the GHR p.Phe279Tyr mutation was found to be significantly associated with protein percentage (P = 0.0014).	Lysine	29-35	diacylglycerol O-acyltransferase 1	Bos taurus	4-9
19631193-7	2009	V8 protease digestion of both CXCR4/125I-[Bpa(5)]T140 and CXCR4/125I-[Bpa(10)]T140 adducts generated a fragment of 6kDa suggesting that the T140 photoanalogs labeled a fragment corresponding to Lys(154)-Glu(179) of the receptor"s 4th transmembrane domain.	Lysine	194-197	C-X-C motif chemokine receptor 4	Homo sapiens	30-35
19631193-7	2009	V8 protease digestion of both CXCR4/125I-[Bpa(5)]T140 and CXCR4/125I-[Bpa(10)]T140 adducts generated a fragment of 6kDa suggesting that the T140 photoanalogs labeled a fragment corresponding to Lys(154)-Glu(179) of the receptor"s 4th transmembrane domain.	Lysine	194-197	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
19744555-7	2009	The sumoylation site was identified at lysine 25 of FOXL2.	Lysine	39-45	forkhead box L2	Homo sapiens	52-57
19744555-9	2009	Taken together, we propose that Ubc9-mediated sumoylation at lysine 25 of FOXL2 is required for transcriptional repression of the StAR gene and may be responsible for controlling the development of ovarian follicles.	Lysine	61-67	forkhead box L2	Homo sapiens	74-79
19822661-3	2009	Specifically, deleting as few as 20 amino acids, or substituting glutamines for lysines in the tail, greatly impaired K36 methylation by Set2.	Lysine	80-87	keratin 36	Homo sapiens	118-121
19944020-0	2009	The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity.	Lysine	84-90	ubiquitin interaction motif containing 1	Homo sapiens	62-67
19801601-2	2009	Bacterial propionyl-CoA synthetase and human histone H4 are propionylated at specific lysine residues that have been known previously to be acetylated.	Lysine	86-92	H4 clustered histone 9	Homo sapiens	45-55
19732750-3	2009	A chromatin immunoprecipitation assay showed that Jmjd2c was recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes.	Lysine	151-157	lysine demethylase 4C	Homo sapiens	50-56
19732750-3	2009	A chromatin immunoprecipitation assay showed that Jmjd2c was recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes.	Lysine	151-157	MDM2 proto-oncogene	Homo sapiens	100-104
19883617-3	2009	Lysine 217 of FXR is the major acetylation site targeted by p300 and SIRT1.	Lysine	0-6	E1A binding protein p300	Mus musculus	60-64
19787249-4	2009	NRAS gene analysis revealed a CAA --&gt; AAA substitution at codon 61, resulting in a Glu --&gt; Lys change at position 61.	Lysine	97-100	NRAS proto-oncogene, GTPase	Homo sapiens	0-4
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	MDM2 proto-oncogene	Homo sapiens	0-4
19808967-5	2009	MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation.	Lysine	168-174	MDM2 proto-oncogene	Homo sapiens	132-136
19783674-4	2009	However, replacement of Glu122, Leu125, and/or Asn58 of mMD-2 with the corresponding residues (lysines) of hMD-2 was sufficient to yield soluble extracellular MD-2 that reacted with monomeric E .	Lysine	95-102	lymphocyte antigen 96	Homo sapiens	107-112
19605472-6	2009	Upon exit of the protein from the endoplasmic reticulum, lysines in the short amino-terminal domain of BST2 are ubiquitinated by K5, resulting in rapid degradation of BST2.	Lysine	57-64	bone marrow stromal cell antigen 2	Homo sapiens	103-107
19605472-6	2009	Upon exit of the protein from the endoplasmic reticulum, lysines in the short amino-terminal domain of BST2 are ubiquitinated by K5, resulting in rapid degradation of BST2.	Lysine	57-64	bone marrow stromal cell antigen 2	Homo sapiens	167-171
19605472-7	2009	Ubiquitination of BST2 is required for degradation, since BST2 lacking cytosolic lysines was K5 resistant and ubiquitin depletion by proteasome inhibitors restored BST2 surface expression.	Lysine	81-88	bone marrow stromal cell antigen 2	Homo sapiens	18-22
19605472-7	2009	Ubiquitination of BST2 is required for degradation, since BST2 lacking cytosolic lysines was K5 resistant and ubiquitin depletion by proteasome inhibitors restored BST2 surface expression.	Lysine	81-88	bone marrow stromal cell antigen 2	Homo sapiens	58-62
19605472-7	2009	Ubiquitination of BST2 is required for degradation, since BST2 lacking cytosolic lysines was K5 resistant and ubiquitin depletion by proteasome inhibitors restored BST2 surface expression.	Lysine	81-88	bone marrow stromal cell antigen 2	Homo sapiens	58-62
19782027-2	2009	Sir3 binds to nucleosomes containing deacetylated histone H4 lysine 16 (H4K16) and, with Sir4, promotes spreading of Sir2 and deacetylation along the chromatin fiber.	Lysine	61-67	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	0-4
19597476-7	2009	In stressed cells, HSP27 enters the nucleus and, in the form of large oligomers, binds to HSF1 and induces its modification by SUMO-2/3 on lysine 298.	Lysine	139-145	small ubiquitin like modifier 2	Homo sapiens	127-133
19663398-2	2009	The carboxy-terminal domain (CTD) of histone H1 is very basic with approximately 40% Lys residues, approximately 75% of which are present as doublets.	Lysine	85-88	H1.0 linker histone	Homo sapiens	37-47
19596784-4	2009	Here we report that amino acid substitutions of arginines with lysines in the basic domain of TRF2 induce telomere dysfunction-induced focus formation, leading to induction of cellular senescence.	Lysine	63-70	telomeric repeat binding factor 2	Homo sapiens	94-98
19596784-5	2009	We have demonstrated that cells overexpressing TRF2 lysine mutants accumulate telomere doublets, indicative of telomere instability.	Lysine	52-58	telomeric repeat binding factor 2	Homo sapiens	47-51
19596784-8	2009	We found that depletion of PRMT1 in normal human cells results in accumulation of telomere doublets, indistinguishable from overexpression of TRF2 lysine mutants.	Lysine	147-153	protein arginine methyltransferase 1	Homo sapiens	27-32
19591226-5	2009	Here, we identify a key lysine residue in the nuclear export signal of Sox2 that is acetylated, and demonstrate that blocking acetylation at this site retains Sox2 in the nucleus and sustains expression of its target genes under hyperacetylation or differentiation conditions.	Lysine	24-30	SRY-box transcription factor 2	Homo sapiens	71-75
19591226-5	2009	Here, we identify a key lysine residue in the nuclear export signal of Sox2 that is acetylated, and demonstrate that blocking acetylation at this site retains Sox2 in the nucleus and sustains expression of its target genes under hyperacetylation or differentiation conditions.	Lysine	24-30	SRY-box transcription factor 2	Homo sapiens	159-163
19589784-2	2009	Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair.	Lysine	70-73	FA complementation group D2	Homo sapiens	150-156
19542228-7	2009	Mutating Leu-508 in the little finger domain of hPol kappa to lysine modulates the insertion opposite 8-oxoG toward more accurate bypass, similar to previous findings with Dpo4.	Lysine	62-68	DNA polymerase lambda	Homo sapiens	48-58
19694578-0	2009	Receptor-binding, biodistribution, dosimetry, and micro-SPECT/CT imaging of 111In-[DTPA(1), Lys(3), Tyr(4)]-bombesin analog in human prostate tumor-bearing mice.	Lysine	92-95	gastrin releasing peptide	Homo sapiens	108-116
19694578-7	2009	The IC(50) and K(i) of [DTPA(1), Lys(3), Tyr(4)]-BN in the human bombesin 2 receptor were 1.05 +/- 0.46 and 0.83 +/- 0.36 nM, respectively.	Lysine	33-36	gastrin releasing peptide	Homo sapiens	65-73
19359510-8	2009	For the 35-d period, ADG and ADFI increased linearly (P &lt; 0.01) and quadratically (P &lt; 0.01) with increasing SID Val:Lys.	Lysine	123-126	ADG	Sus scrofa	21-24
19359510-16	2009	Estimates of optimum SID Val:Lys were 66, 67, and 61% for ADG, ADFI, and G:F, respectively.	Lysine	29-32	ADG	Sus scrofa	58-61
19473979-7	2009	This motif is located within the L16 extension lying C-terminal to the CD domain in ERK3 and ERK4 and a single isoleucine to lysine substitution in FRIEDE totally abrogates binding, activation, and translocation of MK5 by both ERK3 and ERK4.	Lysine	125-131	MAPK activated protein kinase 5	Homo sapiens	215-218
19423702-10	2009	Remarkably, the cleavage specificity of HigB coincided with one of the most frequently used codons in the AT-rich Proteus spp., AAA (lysine).	Lysine	133-139	higB	Proteus vulgaris	40-44
19494831-0	2009	Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.	Lysine	33-39	Scm-related gene containing four mbt domains	Drosophila melanogaster	84-90
19549823-2	2009	Here, we describe the monomer structures of C-terminal truncated archaeal AlaRS, with both activation and editing domains in the apo form, in complex with an Ala-AMP analog, and in a high-resolution lysine-methylated form.	Lysine	199-205	alanyl-tRNA synthetase 1	Homo sapiens	74-79
19593370-0	2009	Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD).	Lysine	28-34	FSHMD1A	Homo sapiens	147-151
19407342-2	2009	The recent discovery of lysine-specific demethylase 1 (LSD1) demonstrated that lysine methylation can be dynamically controlled.	Lysine	24-30	lysine demethylase 1A	Homo sapiens	55-59
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	CD44 molecule (Indian blood group)	Homo sapiens	53-57
19336407-2	2009	Typically, the first ubiquitin is linked to lysine residues in the substrate for degradation via an isopeptide bond, although rarely ubiquitin linkage to the N-terminal residue has also been observed.	Lysine	44-50	ubiquitin B S homeolog	Xenopus laevis	21-30
19336407-5	2009	NGN can be targeted for destruction by ubiquitylation via lysines or the N terminus.	Lysine	58-65	neurogenin 1 L homeolog	Xenopus laevis	0-3
19336407-6	2009	However, we see that a modified NGN, where canonical lysine ubiquitylation and N-terminally linked ubiquitylation are prevented, is nevertheless ubiquitylated and degraded by the proteasome.	Lysine	53-59	neurogenin 1 L homeolog	Xenopus laevis	32-35
19346168-2	2009	Fabrication steps and electrochemical interaction of Au-MPA-LOx with L-lysine were monitored by general electrochemical methods like cyclic voltammetry (CV) and chronoamperometry (CA), and by a more advanced method, electrochemical impedance spectroscopy (EIS) in the presence of parabenzoquinone (PBQ) redox probe.	Lysine	69-77	lysyl oxidase	Homo sapiens	60-63
19346168-5	2009	Our initial tests revealed a linear response for Au-MPA-LOx SAM electrode toward L-lysine concentration in solution at biological conditions, pH 7.4.	Lysine	81-89	lysyl oxidase	Homo sapiens	56-59
21468177-2	2009	Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and attachment of Ub to a target protein is mediated by the action of three enzymes (i.e., E1, E2, and E3).	Lysine	45-51	cystatin 12, pseudogene	Homo sapiens	196-206
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	PR/SET domain 2	Homo sapiens	175-178
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	signal transducer and activator of transcription 1	Homo sapiens	297-302
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	304-311
19472189-2	2009	It could specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes, including of several oncogenes (e.g., N-Myc, CrkL, Wnt10b, RIZ, and hTERT) and genes involved in the control of cell cycle (e.g., Cyclin G1 and CDK2) and signal transduction (e.g., STAT1, MAP3K11, and PIK3CB).	Lysine	46-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	317-323
19131354-10	2009	One (p.K301M) produced a lysine to methionine change in the third interactive SH3 domain (position 301) and resulted in the defective CD2-CD2AP interaction and clustering; the other (c.1573delAGA) caused the deletion of the glutamic acid in position 525 in the COOH-terminal region of binding with nephrin and was associated with down-modulation of CD2AP, podocin and nephrin glomerular expression.	Lysine	25-31	NPHS1 adhesion molecule, nephrin	Homo sapiens	298-305
19131354-10	2009	One (p.K301M) produced a lysine to methionine change in the third interactive SH3 domain (position 301) and resulted in the defective CD2-CD2AP interaction and clustering; the other (c.1573delAGA) caused the deletion of the glutamic acid in position 525 in the COOH-terminal region of binding with nephrin and was associated with down-modulation of CD2AP, podocin and nephrin glomerular expression.	Lysine	25-31	NPHS1 adhesion molecule, nephrin	Homo sapiens	368-375
19366580-5	2009	Using a recombinant infectious clone of RP-9, we found that a single Glu--&gt;Lys mutation at residue 138 of the envelope protein (E-E138K) rendered the mutated RP-9 sensitive to the antiviral effect of IFN-alpha.	Lysine	78-81	RP9 pre-mRNA splicing factor	Homo sapiens	40-44
19366580-5	2009	Using a recombinant infectious clone of RP-9, we found that a single Glu--&gt;Lys mutation at residue 138 of the envelope protein (E-E138K) rendered the mutated RP-9 sensitive to the antiviral effect of IFN-alpha.	Lysine	78-81	RP9 pre-mRNA splicing factor	Homo sapiens	161-165
19448855-0	2009	Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures.	Lysine	13-19	histone deacetylase 9	Homo sapiens	101-120
19102726-0	2009	Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin.	Lysine	0-6	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	125-140
19343071-3	2009	GCN5 specifically acetylates CDC6 at three lysine residues flanking its cyclin-docking motif, and this modification is crucial for the subsequent phosphorylation of the protein by Cyclin A-CDKs at a specific residue close to the acetylation site.	Lysine	43-49	lysine acetyltransferase 2A	Homo sapiens	0-4
19188254-4	2009	Simultaneous deletion of SEM1 and UBP6 induces dramatic silencing defect accompanied by significantly increased level of ubiquitinated-histone H2B and markedly reduced levels of acetylated-lysine 14 and 23 on histone H3 at the telomeres.	Lysine	189-195	ubiquitin-specific protease UBP6	Saccharomyces cerevisiae S288C	34-38
19282482-3	2009	SET7 colocalizes and directly interacts with DNMT1 and specifically monomethylates Lys-142 of DNMT1.	Lysine	83-86	DNA methyltransferase 1	Homo sapiens	94-99
19212323-9	2009	In differentiating wild-type subventricular zone cells, Mash1, Olig2 and Dlx2 loci have high levels of histone 3 trimethylated at lysine 4 (H3K4me3), consistent with their transcription.	Lysine	130-136	achaete-scute family bHLH transcription factor 1	Mus musculus	56-61
19212323-9	2009	In differentiating wild-type subventricular zone cells, Mash1, Olig2 and Dlx2 loci have high levels of histone 3 trimethylated at lysine 4 (H3K4me3), consistent with their transcription.	Lysine	130-136	distal-less homeobox 2	Mus musculus	73-77
19212323-10	2009	In contrast, in Mll1-deficient subventricular zone cells, chromatin at Dlx2 is bivalently marked by both H3K4me3 and histone 3 trimethylated at lysine 27 (H3K27me3), and the Dlx2 gene fails to properly activate.	Lysine	144-150	distal-less homeobox 2	Mus musculus	71-75
19361442-6	2009	The carboxylate residues that coordinate two Ca(2+) in the NCX1-CBD1 structure are neutralized by two Lys residues in CALX1.1-CBD2.	Lysine	102-105	Na/Ca-exchange protein	Drosophila melanogaster	118-125
19261746-4	2009	Moreover, MERIT40 is required for Rap80-associated lysine(63)-ubiquitin DUB activity, a critical component of BRCA1-Rap80 G2 checkpoint and viability responses to ionizing radiation.	Lysine	51-57	ubiquitin interaction motif containing 1	Homo sapiens	34-39
19261746-4	2009	Moreover, MERIT40 is required for Rap80-associated lysine(63)-ubiquitin DUB activity, a critical component of BRCA1-Rap80 G2 checkpoint and viability responses to ionizing radiation.	Lysine	51-57	BRCA1 DNA repair associated	Homo sapiens	110-115
19261746-4	2009	Moreover, MERIT40 is required for Rap80-associated lysine(63)-ubiquitin DUB activity, a critical component of BRCA1-Rap80 G2 checkpoint and viability responses to ionizing radiation.	Lysine	51-57	ubiquitin interaction motif containing 1	Homo sapiens	116-121
19168755-6	2009	Sna4p is polyubiquitylated on its only lysine, and Sna4p lacking this lysine shows defective MVB sorting.	Lysine	39-45	Sna4p	Saccharomyces cerevisiae S288C	0-5
19168755-6	2009	Sna4p is polyubiquitylated on its only lysine, and Sna4p lacking this lysine shows defective MVB sorting.	Lysine	70-76	Sna4p	Saccharomyces cerevisiae S288C	51-56
19188499-4	2009	In Gfi1(-/-) Th2 cells, the Rorc, Il23r, and Cd103 loci showed histone 3 lysine 4 trimethylation modifications that were lacking in wild-type Th2 cells, implying that Gfi-1 is critical for epigenetic regulation of Th17 and iTreg cell-related genes in Th2 cells.	Lysine	73-79	growth factor independent 1 transcription repressor	Mus musculus	3-7
18983266-6	2009	Arg(333) and Lys(348) in the C-terminal tail of the beta2AR were identified as crucial determinants for Rab11 binding.	Lysine	13-16	adrenoceptor beta 2	Homo sapiens	52-59
19217413-5	2009	We provide evidence that the phosphorylated residues contact lysine 39 and 35 in SUMO1 and SUMO2, respectively.	Lysine	61-67	small ubiquitin like modifier 2	Homo sapiens	91-96
19138112-1	2009	A photoaffinity probe, developed for the specific labeling of matrix metalloproteinase (MMP) active sites, was recently shown to covalently modify a single residue in human MMP-12, namely, Lys(241), by reacting selectively with the side chain epsilon-amino group of that residue.	Lysine	189-192	matrix metallopeptidase 12	Homo sapiens	173-179
19187765-3	2009	Here we show a critical role for specific recognition of histone H3 trimethylated at lysine 4 (H3K4me3) by the ING4 PHD finger in mediating ING4 gene expression and tumor suppressor functions.	Lysine	85-91	inhibitor of growth family member 4	Homo sapiens	111-115
19187765-3	2009	Here we show a critical role for specific recognition of histone H3 trimethylated at lysine 4 (H3K4me3) by the ING4 PHD finger in mediating ING4 gene expression and tumor suppressor functions.	Lysine	85-91	inhibitor of growth family member 4	Homo sapiens	140-144
19041634-3	2009	SUMOylation of RORalpha occurred on the 240th lysine residue at the hinge region of human protein.	Lysine	46-52	RAR related orphan receptor A	Homo sapiens	15-23
19010784-3	2009	We discovered that plasma carboxypeptidase N (CPN) and B (CPB or activated thrombin-activable fibrinolysis inhibitor, TAFIa) enhanced the bioactivity of 10-mer chemerin peptide NH(2)-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine (K).	Lysine	233-239	carboxypeptidase N subunit 1	Homo sapiens	26-56
19010784-3	2009	We discovered that plasma carboxypeptidase N (CPN) and B (CPB or activated thrombin-activable fibrinolysis inhibitor, TAFIa) enhanced the bioactivity of 10-mer chemerin peptide NH(2)-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine (K).	Lysine	233-239	carboxypeptidase B1	Homo sapiens	58-61
19010784-3	2009	We discovered that plasma carboxypeptidase N (CPN) and B (CPB or activated thrombin-activable fibrinolysis inhibitor, TAFIa) enhanced the bioactivity of 10-mer chemerin peptide NH(2)-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine (K).	Lysine	233-239	retinoic acid receptor responder 2	Homo sapiens	160-168
19017631-2	2009	Activation of RIG-I requires the ubiquitin ligase, TRIM25, which mediates lysine 63-linked polyubiquitination of the RIG-I N-terminal CARD-like region.	Lysine	74-80	DExD/H-box helicase 58	Homo sapiens	14-19
19017631-2	2009	Activation of RIG-I requires the ubiquitin ligase, TRIM25, which mediates lysine 63-linked polyubiquitination of the RIG-I N-terminal CARD-like region.	Lysine	74-80	DExD/H-box helicase 58	Homo sapiens	117-122
19017631-7	2009	Riplet/RNF135 promotes lysine 63-linked polyubiquitination of the C-terminal region of RIG-I, modification of which differs from the N-terminal ubiquitination by TRIM25.	Lysine	23-29	ring finger protein 135	Homo sapiens	0-6
19017631-7	2009	Riplet/RNF135 promotes lysine 63-linked polyubiquitination of the C-terminal region of RIG-I, modification of which differs from the N-terminal ubiquitination by TRIM25.	Lysine	23-29	ring finger protein 135	Homo sapiens	7-13
19017631-7	2009	Riplet/RNF135 promotes lysine 63-linked polyubiquitination of the C-terminal region of RIG-I, modification of which differs from the N-terminal ubiquitination by TRIM25.	Lysine	23-29	DExD/H-box helicase 58	Homo sapiens	87-92
18951927-3	2009	Initially, three types of site-specific (Lys(34)) PEGylated GLP-1 analogs were synthesized using PEGs of 2, 5, and 10 kDa, respectively.	Lysine	41-44	glucagon	Rattus norvegicus	60-65
19109177-4	2009	To test the possible involvement of the homologous residues Lys(57) of L-ficolin and Lys(47) of H-ficolin, point mutants of both proteins were produced in which these residues were mutated to Ala, Glu, or Arg.	Lysine	60-63	ficolin 2	Homo sapiens	71-80
19109177-9	2009	In conclusion, residues Lys(57) of L-ficolin and Lys(47) of H-ficolin are key components of the interaction with the MASPs and CRT, providing strong indication that MBL and the ficolins share homologous binding sites for both types of proteins.	Lysine	24-27	ficolin 2	Homo sapiens	35-44
18981181-5	2008	GLUT1 lysine residues were modified by isothiocyanates and N-hydroxysuccinimide (NHS) esters in a substrate-dependent manner.	Lysine	6-12	solute carrier family 2 member 1	Homo sapiens	0-5
18984594-3	2008	Eaf3 contains a chromo domain at the N terminus that can bind to methylated Lys-36 of histone H3 (H3K36).	Lysine	76-79	Eaf3p	Saccharomyces cerevisiae S288C	0-4
18990703-9	2008	Inhibition of Parp-1 activity (by 3-AB) reduced histone 3 lysine 9 acetylation and blocked Parp-1 binding to the BRCA2 promoter.	Lysine	58-64	BRCA2 DNA repair associated	Homo sapiens	113-118
18957409-2	2008	The methylation of Lys-40 is dependent upon the Ybr030w gene product; the methylation of Lys-55 is dependent upon the Set7 gene product.	Lysine	89-92	ribosomal lysine N-methyltransferase	Saccharomyces cerevisiae S288C	118-122
18978082-4	2008	Differences in the cell-binding rates of each nukacin ISK-1 derivative suggested that three lysine residues at positions 1 to 3 of nukacin ISK-1 contribute to the effective binding of nukacin ISK-1 to nukH-expressing cells.	Lysine	92-98	NukH	Staphylococcus warneri	201-205
19134269-6	2008	In FHL family, mutation G15391A was identified in exon 23 of MYH7 gene in 3 family members [the glutamic acid (E) converted to lysine (K)].	Lysine	127-133	myosin heavy chain 7	Homo sapiens	61-65
18841999-0	2008	Accelerated dephosphorylation of the beta2-adrenergic receptor by mutation of the C-terminal lysines: effects on ubiquitination, intracellular trafficking, and degradation.	Lysine	93-100	adrenoceptor beta 2	Homo sapiens	37-62
18841999-3	2008	To explore the roles of the two post-translational modifications, we mutated the three C-terminal lysines to arginines in the human beta 2-adrenergic receptor (beta 2AR) (K348/372/375R).	Lysine	98-105	adrenoceptor beta 2	Homo sapiens	160-168
18849969-6	2008	In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1).	Lysine	68-71	E1A binding protein p300	Mus musculus	9-13
18849969-6	2008	In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1).	Lysine	68-71	COP1, E3 ubiquitin ligase	Mus musculus	205-209
18977328-4	2008	The molecular target of E6 in the NF-kappaB pathway is the CYLD lysine 63 (K63) deubiquitinase, a negative regulator of the NF-kappaB pathway.	Lysine	64-70	CYLD lysine 63 deubiquitinase	Homo sapiens	59-63
18777182-1	2008	The 16-mer peptide nucleic acid sequence H-A GAT CAT GCC CGG CAT-Lys-NH2 (1), which is complementary to the translation start region of the N-myc oncogene messenger RNA, was synthesized and conjugated to a pyrazolyl diamine bifunctional chelator (pz).	Lysine	65-68	glycine-N-acyltransferase	Homo sapiens	45-48
18713730-4	2008	GRAIL bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues.	Lysine	160-166	ring finger protein 128	Homo sapiens	0-5
18713730-4	2008	GRAIL bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues.	Lysine	160-166	CD151 molecule (Raph blood group)	Homo sapiens	57-62
18713730-4	2008	GRAIL bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues.	Lysine	160-166	CD81 molecule	Homo sapiens	91-95
18713730-5	2008	GRAIL exhibited specificity for lysines only within the tetraspanin amino terminus even in the presence of other cytosolic lysine residues in the substrate.	Lysine	32-39	ring finger protein 128	Homo sapiens	0-5
18713730-5	2008	GRAIL exhibited specificity for lysines only within the tetraspanin amino terminus even in the presence of other cytosolic lysine residues in the substrate.	Lysine	32-38	ring finger protein 128	Homo sapiens	0-5
18713730-6	2008	GRAIL-mediated ubiquitination promoted proteasomal degradation and cell surface down-regulation of tetraspanins via Lys-48 linkages.	Lysine	116-119	ring finger protein 128	Homo sapiens	0-5
18923077-3	2008	We identified a critical lysine residue in histone H4 that is needed for interaction with Set2 and proper H3 K36 di- and trimethylation.	Lysine	25-31	H4 clustered histone 9	Homo sapiens	43-53
18682534-3	2008	In this study, we identified a novel recessive FGF23 TC mutation, a lysine (K) substitution for glutamine (Q) (160 C&gt;A) at residue 54 (Q54K).	Lysine	68-74	fibroblast growth factor 23	Homo sapiens	47-52
18843197-5	2008	The inhibition of the Socs1 expression in HCC was associated with an increase in histone H3 lysine 9, H3 lysine 27, and H4 lysine 20 trimethylation at the Socs1 promoter, but not with promoter methylation.	Lysine	92-98	suppressor of cytokine signaling 1	Rattus norvegicus	22-27
18843197-5	2008	The inhibition of the Socs1 expression in HCC was associated with an increase in histone H3 lysine 9, H3 lysine 27, and H4 lysine 20 trimethylation at the Socs1 promoter, but not with promoter methylation.	Lysine	105-111	suppressor of cytokine signaling 1	Rattus norvegicus	22-27
18843197-5	2008	The inhibition of the Socs1 expression in HCC was associated with an increase in histone H3 lysine 9, H3 lysine 27, and H4 lysine 20 trimethylation at the Socs1 promoter, but not with promoter methylation.	Lysine	105-111	suppressor of cytokine signaling 1	Rattus norvegicus	22-27
18781795-2	2008	We previously reported Lys (347) trimethylation of mouse retinoic acid receptor alpha (RAR alpha) in the ligand binding domain (LBD) that affected ligand sensitivity of the dissected LBD.	Lysine	23-26	retinoic acid receptor, alpha	Mus musculus	57-85
18781795-2	2008	We previously reported Lys (347) trimethylation of mouse retinoic acid receptor alpha (RAR alpha) in the ligand binding domain (LBD) that affected ligand sensitivity of the dissected LBD.	Lysine	23-26	retinoic acid receptor, alpha	Mus musculus	87-96
18781795-3	2008	Here we report two monomethylated residues, Lys (109) and Lys (171) identified by LC-ESI-MS/MS in the DNA binding domain (DBD) and the hinge region, which affect retinoic acid (RA) sensitivity, coregulator interaction and heterodimerization with retinoid X receptor (RXR) in the context of the full-length protein.	Lysine	44-47	retinoid X receptor alpha	Homo sapiens	246-265
18781795-3	2008	Here we report two monomethylated residues, Lys (109) and Lys (171) identified by LC-ESI-MS/MS in the DNA binding domain (DBD) and the hinge region, which affect retinoic acid (RA) sensitivity, coregulator interaction and heterodimerization with retinoid X receptor (RXR) in the context of the full-length protein.	Lysine	44-47	retinoid X receptor alpha	Homo sapiens	267-270
18781795-3	2008	Here we report two monomethylated residues, Lys (109) and Lys (171) identified by LC-ESI-MS/MS in the DNA binding domain (DBD) and the hinge region, which affect retinoic acid (RA) sensitivity, coregulator interaction and heterodimerization with retinoid X receptor (RXR) in the context of the full-length protein.	Lysine	58-61	retinoid X receptor alpha	Homo sapiens	246-265
18781795-3	2008	Here we report two monomethylated residues, Lys (109) and Lys (171) identified by LC-ESI-MS/MS in the DNA binding domain (DBD) and the hinge region, which affect retinoic acid (RA) sensitivity, coregulator interaction and heterodimerization with retinoid X receptor (RXR) in the context of the full-length protein.	Lysine	58-61	retinoid X receptor alpha	Homo sapiens	267-270
18684814-8	2008	This suggests that interaction of Env with cellular components required for SVP release suppression is effective only when Env is ubiquitinated at these lysine residues but not at others.	Lysine	153-159	endogenous retrovirus group K member 20	Homo sapiens	34-37
18684814-8	2008	This suggests that interaction of Env with cellular components required for SVP release suppression is effective only when Env is ubiquitinated at these lysine residues but not at others.	Lysine	153-159	endogenous retrovirus group K member 20	Homo sapiens	123-126
18846226-7	2008	The presence of two chromodomains in KIS-L suggested that its recruitment or function might be regulated by the methylation of histone H3 lysine 4 by the trithorax group proteins ASH1 and TRX.	Lysine	138-144	trithorax	Drosophila melanogaster	188-191
18846226-10	2008	A similar increase in H3 lysine 27 methylation was observed in ash1 and trx mutant larvae.	Lysine	25-31	trithorax	Drosophila melanogaster	72-75
18599482-5	2008	Ataxin-3 shows even greater activity toward mixed linkage polyubiquitin, cleaving Lys(63) linkages in chains that contain both Lys(48) and Lys(63) linkages.	Lysine	82-85	ataxin 3	Homo sapiens	0-8
18599482-5	2008	Ataxin-3 shows even greater activity toward mixed linkage polyubiquitin, cleaving Lys(63) linkages in chains that contain both Lys(48) and Lys(63) linkages.	Lysine	127-130	ataxin 3	Homo sapiens	0-8
18599482-5	2008	Ataxin-3 shows even greater activity toward mixed linkage polyubiquitin, cleaving Lys(63) linkages in chains that contain both Lys(48) and Lys(63) linkages.	Lysine	127-130	ataxin 3	Homo sapiens	0-8
18647749-0	2008	G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.	Lysine	13-19	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
18647749-5	2008	A conserved lysine residue in the C/EBPbeta TAD served as a substrate for G9a-mediated methylation.	Lysine	12-18	euchromatic histone lysine methyltransferase 2	Homo sapiens	74-77
18647749-7	2008	A C/EBPbeta TAD mutant that contained a lysine-to-alanine exchange was resistant to G9a-mediated inhibition.	Lysine	40-46	euchromatic histone lysine methyltransferase 2	Homo sapiens	84-87
18650421-9	2008	Microarray profiling revealed that, in TNF-alpha-stimulated monocytes, the induction of 25% NF-kappaB downstream genes, including the histone H3-lysine 27 demethylase JMJD3, was attenuated by SET7/9 depletion.	Lysine	145-151	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	167-172
18622015-7	2008	The recruitment of HDAC1 to c-Myc and FoxM1B promoters leads to deacetylation of histone H3 at Lys-9 on these E2F-dependent promoters.	Lysine	95-98	forkhead box M1	Mus musculus	38-44
18701922-6	2008	ACD-1 (acid-sensitive channel, degenerin-like) is constitutively open and impermeable to Ca(2+), yet it is required with neuronal DEG/ENaC channel DEG-1 for acid avoidance and chemotaxis to the amino acid lysine.	Lysine	205-211	Uncharacterized protein	Caenorhabditis elegans	0-5
18701922-6	2008	ACD-1 (acid-sensitive channel, degenerin-like) is constitutively open and impermeable to Ca(2+), yet it is required with neuronal DEG/ENaC channel DEG-1 for acid avoidance and chemotaxis to the amino acid lysine.	Lysine	205-211	Degenerin deg-1	Caenorhabditis elegans	147-152
18688044-4	2008	Chromatin immunoprecipitation assays showed that levels of histone H3 lysine 4 dimethylation (H3K4me2), a key chromatin mark associated with active gene expression, were significantly elevated at the promoters of the inflammatory genes monocyte chemoattractant protein-1 and interleukin-6 in db/db VSMCs relative to db/+ cells.	Lysine	70-76	chemokine (C-C motif) ligand 2	Mus musculus	236-270
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Lysine	117-120	MDM2 proto-oncogene	Homo sapiens	25-29
18707164-3	2008	The specific residues of MDM2 that have dominant binding interactions with p53 are specifically identified to be (51)Lys, (54)Leu, (62)Met, (67)Tyr, (72)Gln, (94)Lys, (96)His, and (100)Tyr.	Lysine	162-165	MDM2 proto-oncogene	Homo sapiens	25-29
18671409-5	2008	Both Rtt109 and Asf1 were previously found to be essential for acetylation of histone H3 lysine 56 (H3K56ac), a modification that plays an important role in the response to genotoxic agents that interfere with DNA replication.	Lysine	89-95	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	16-20
18636086-3	2008	Microarray and bioinformatic analysis indicated that the expression of RIG-I and that of the tumour suppressor CYLD (cylindromatosis), a deubiquitinating enzyme that removes Lys 63-linked polyubiquitin chains, are closely correlated, suggesting a functional association between the two molecules.	Lysine	174-177	DExD/H-box helicase 58	Homo sapiens	71-76
18636086-3	2008	Microarray and bioinformatic analysis indicated that the expression of RIG-I and that of the tumour suppressor CYLD (cylindromatosis), a deubiquitinating enzyme that removes Lys 63-linked polyubiquitin chains, are closely correlated, suggesting a functional association between the two molecules.	Lysine	174-177	CYLD lysine 63 deubiquitinase	Homo sapiens	111-115
18636086-3	2008	Microarray and bioinformatic analysis indicated that the expression of RIG-I and that of the tumour suppressor CYLD (cylindromatosis), a deubiquitinating enzyme that removes Lys 63-linked polyubiquitin chains, are closely correlated, suggesting a functional association between the two molecules.	Lysine	174-177	CYLD lysine 63 deubiquitinase	Homo sapiens	117-132
18719104-1	2008	Rtt109 is a protein acetyltransferase (PAT) that is responsible for the acetylation of lysine-56 of histone 3 (H3K56) in yeast.	Lysine	87-93	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	0-6
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Lysine	57-60	LDL receptor related protein 6	Homo sapiens	132-136
18676613-4	2008	On the other hand, a chimeric molecule encompassing the extracellular domain of Dll1 and the transmembrane/intracellular domain of Dll3, which contains no lysine, is endocytosed, recycled, and interacts with Notch1 but is unable to induce transendocytosis of the extracellular region of Notch1 or to signal.	Lysine	155-161	delta like canonical Notch ligand 3	Mus musculus	131-135
18688271-5	2008	Using evolutionary analysis and resurrected ancestral protein variants, we demonstrate that the enhanced mitochondrial targeting specificity of GLUD2 is due to a single positively selected glutamic acid-to-lysine substitution, which was fixed in the N-terminal mitochondrial targeting sequence (MTS) of GLUD2 soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago.	Lysine	206-212	glutamate dehydrogenase 2	Homo sapiens	144-149
18653893-4	2008	An acetylation-mimicking mutation of a conserved lysine in cohesin"s Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion.	Lysine	49-55	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	69-73
18653893-4	2008	An acetylation-mimicking mutation of a conserved lysine in cohesin"s Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion.	Lysine	49-55	Eco1p	Saccharomyces cerevisiae S288C	88-92
18653893-4	2008	An acetylation-mimicking mutation of a conserved lysine in cohesin"s Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion.	Lysine	49-55	cohesin subunit SMC3	Saccharomyces cerevisiae S288C	139-143
18653893-4	2008	An acetylation-mimicking mutation of a conserved lysine in cohesin"s Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion.	Lysine	49-55	Eco1p	Saccharomyces cerevisiae S288C	164-168
18458088-4	2008	Interestingly, the ubiquitin-dependent degradation of exogenous ATF5 protein was independent of lysine residues.	Lysine	96-102	activating transcription factor 5	Homo sapiens	64-68
18627314-4	2008	Enzymatically active recombinant azurocidin caused cleavage of the C-terminal fusion tag with the primary cleavage site after lysine at Lys-Leu and after alanine at Ala-Ala, and the secondary cleavage site after arginine at Arg-Gln, as well as with low efficiency caused cleavage of insulin chain B after leucine at Leu-Tyr and Leu-Cys, and after alanine at Ala-Leu.	Lysine	126-132	azurocidin 1	Homo sapiens	33-43
18627314-4	2008	Enzymatically active recombinant azurocidin caused cleavage of the C-terminal fusion tag with the primary cleavage site after lysine at Lys-Leu and after alanine at Ala-Ala, and the secondary cleavage site after arginine at Arg-Gln, as well as with low efficiency caused cleavage of insulin chain B after leucine at Leu-Tyr and Leu-Cys, and after alanine at Ala-Leu.	Lysine	136-139	azurocidin 1	Homo sapiens	33-43
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Lysine	108-114	lysine acetyltransferase 2A	Homo sapiens	47-52
18408014-3	2008	These proteins, working in concert, enhanced SUMO conjugation to lysine-744 of SATB1.	Lysine	65-71	SATB homeobox 1	Homo sapiens	79-84
18504304-5	2008	MKP-1 is acetylated by p300 on lysine residue K57 within its substrate-binding domain.	Lysine	31-37	dual specificity phosphatase 1	Mus musculus	0-5
18504304-5	2008	MKP-1 is acetylated by p300 on lysine residue K57 within its substrate-binding domain.	Lysine	31-37	E1A binding protein p300	Mus musculus	23-27
18204074-4	2008	In addition, we noted epigenetic alterations including DNA hypermethylation, reduced histone H4 acetylation and a decrease in the ratio of Lys-9 acetylated/methylated histone H3 at the MGMT CpG island in NiS-transformed 16HBE cells.	Lysine	139-142	O-6-methylguanine-DNA methyltransferase	Homo sapiens	185-189
18447755-6	2008	Pea3 contains four other lysines, K222, K256, K318, and K437, embedded in a perfect SUMO consensus motif.	Lysine	25-32	ETS variant transcription factor 4	Homo sapiens	0-4
18447755-7	2008	The contribution of these lysine residues to the regulation of Pea3 activity and their sumoylation pattern was explored using a GAL4-PEA3 chimera devoid of the ETS DNA-binding domain and by analyzing the native protein.	Lysine	26-32	ETS variant transcription factor 4	Homo sapiens	63-67
18447755-7	2008	The contribution of these lysine residues to the regulation of Pea3 activity and their sumoylation pattern was explored using a GAL4-PEA3 chimera devoid of the ETS DNA-binding domain and by analyzing the native protein.	Lysine	26-32	galectin 4	Homo sapiens	128-132
18558650-0	2008	Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.	Lysine	102-108	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	39-43
18490743-9	2008	Using fluorescent chimeras of the extracellular domain of mouse CD8beta fused to the cytoplasmic tails of each isoform, the M-2 isoform was localized in a lysosomal compartment regulated by ubiquitination of a lysine residue (K215) in its cytoplasmic tail.	Lysine	210-216	CD8 antigen, beta chain 1	Mus musculus	64-71
18085515-4	2008	However, our results show that glutarimide formation is sequence dependent and can be inhibited by incorporating an amino acid like Lys(Boc) with steric hindrance from the protecting group.	Lysine	132-135	BOC cell adhesion associated, oncogene regulated	Homo sapiens	136-139
18467490-6	2008	Chromatin immunoprecipitation (ChIP) experiments indicated that histone 3 lysine 9 (H3K9) methylation status was changed in elf6 and ref6 mutants, consistent with recent findings that many Jmj proteins are histone demethylases.	Lysine	74-80	relative of early flowering 6	Arabidopsis thaliana	133-137
18215125-13	2008	Recombinant neurobin processed 17-kDa FGF-2 (fibroblast growth factor-2) at several P(1) lysine and arginine positions to distinct fragments, in a heparin-inhibitable manner, but did not cleave FGF-7, laminin or fibronectin.	Lysine	89-95	transmembrane protease, serine 11c	Mus musculus	12-20
18483254-4	2008	Ik1 decreases methylation and increases acetylation of histone H3 (Lys(9)) at the LDL-R promoter.	Lysine	67-70	low density lipoprotein receptor	Mus musculus	82-87
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	94-97	cytochrome b-245 beta chain	Homo sapiens	234-238
18347018-7	2008	Mutational analysis of the putative Rac-binding site revealed specific residues, particularly Lys-421, Tyr-425, and Lys-426, individually required for Rac-dependent NADPH oxidase activity that are conserved in the Rac-regulated Nox1, Nox2, and Nox3 enzymes but not in Nox4 or Nox5.	Lysine	116-119	cytochrome b-245 beta chain	Homo sapiens	234-238
18080343-2	2008	In this study films of poly(D,L)lactide (P(D,L)LA), have been functionalized with various concentrations of galactose (GAL, 1-5-10%, w/v) conjugated with poly-L-lysine (PLL) using 1-etil-3-(3-diaminopropil) carbodiimide (EDC) as a coupling agent.	Lysine	154-167	PDON2	Homo sapiens	41-49
18212250-3	2008	A hKOR mutant (hKOR-10 KR) in which all 10 intracellular Lys residues were changed to Arg showed greatly reduced basal and agonist-promoted receptor ubiquitination and substantially decreased Dyn A-induced receptor down-regulation, without changing ligand binding affinity, receptor-G protein coupling, or receptor internalization or desensitization.	Lysine	57-60	opioid receptor kappa 1	Homo sapiens	2-6
18212250-3	2008	A hKOR mutant (hKOR-10 KR) in which all 10 intracellular Lys residues were changed to Arg showed greatly reduced basal and agonist-promoted receptor ubiquitination and substantially decreased Dyn A-induced receptor down-regulation, without changing ligand binding affinity, receptor-G protein coupling, or receptor internalization or desensitization.	Lysine	57-60	opioid receptor kappa 1	Homo sapiens	15-19
18208508-7	2008	Replacement of the eight cytoplasmic lysines by arginines results in a marked accumulation of CD1e in trans Golgi network 46+ compartments, its expression on the plasma membrane and a moderate slowing of its transport to Ls.	Lysine	37-44	CD1e molecule	Homo sapiens	94-98
18194664-0	2008	Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase.	Lysine	37-43	heme oxygenase 1	Rattus norvegicus	56-72
18194664-0	2008	Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase.	Lysine	37-43	cytochrome p450 oxidoreductase	Rattus norvegicus	115-146
18194664-1	2008	The lysine residues of rat heme oxygenase-1 (HO-1) were acetylated by acetic anhydride in the absence and presence of NADPH-cytochrome P450 reductase (CPR) or biliverdin reductase (BVR).	Lysine	4-10	heme oxygenase 1	Rattus norvegicus	27-43
18194664-1	2008	The lysine residues of rat heme oxygenase-1 (HO-1) were acetylated by acetic anhydride in the absence and presence of NADPH-cytochrome P450 reductase (CPR) or biliverdin reductase (BVR).	Lysine	4-10	heme oxygenase 1	Rattus norvegicus	45-49
18194664-1	2008	The lysine residues of rat heme oxygenase-1 (HO-1) were acetylated by acetic anhydride in the absence and presence of NADPH-cytochrome P450 reductase (CPR) or biliverdin reductase (BVR).	Lysine	4-10	cytochrome p450 oxidoreductase	Rattus norvegicus	151-154
18245364-7	2008	We propose that the essential function of Esa1 may be to bind acetyl-CoA or lysine substrates and positively regulate the activities of NuA4 and Piccolo NuA4.	Lysine	76-82	NuA4 histone acetyltransferase complex catalytic subunit ESA1	Saccharomyces cerevisiae S288C	42-46
18310453-9	2008	Intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in IA-2/IA-2beta KO than control islets.	Lysine	67-73	protein tyrosine phosphatase, receptor type, N polypeptide 2	Mus musculus	127-135
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	55-58	nucleoporin 62	Homo sapiens	38-41
18083707-6	2008	NMR titration analysis shows that the p62-UBA binds to Lys 48-linked di-ubiquitin with approximately 4-fold lower affinity than to mono-ubiquitin, suggesting preferential binding of the p62-UBA to single ubiquitin units, consistent with the apparent in vivo preference of the p62 protein for Lys 63-linked polyubiquitin chains (which adopt a more open and extended structure).	Lysine	55-58	nucleoporin 62	Homo sapiens	186-189
18177638-2	2008	We examined whether the actin-binding proteins cortactin, vinculin and filamin A are involved in the formation of the earliest extensions of cells spreading over collagen or poly-L-lysine-coated smooth and beaded substrates.	Lysine	174-187	cortactin	Homo sapiens	47-56
18070902-9	2008	The plasminogen-specific inhibitor epsilon-aminocaproic acid blocked the tv-rENO1-plasminogen association, indicating that lysines play a role in binding to tv-rENO1.	Lysine	123-130	enolase 1	Rattus norvegicus	76-81
18070902-9	2008	The plasminogen-specific inhibitor epsilon-aminocaproic acid blocked the tv-rENO1-plasminogen association, indicating that lysines play a role in binding to tv-rENO1.	Lysine	123-130	enolase 1	Rattus norvegicus	160-165
18231594-5	2008	We find that expression of the human p53-Mdm2 module in yeast is sufficient to faithfully recapitulate key aspects of p53 regulation in higher eukaryotes, such as Mdm2-dependent targeting of p53 for degradation, sumoylation at lysine 386 and further regulation of this process by p14(ARF).	Lysine	227-233	MDM2 proto-oncogene	Homo sapiens	41-45
18023905-9	2008	Despite having the best properties, Lys(18)-PEG(5k)-sCT was found to have significantly lower hypocalcemic efficacy than other PEG-sCTs, probably due to its reduced intrinsic bioactivity ( approximately 30% vs. sCT).	Lysine	36-39	secretin	Rattus norvegicus	52-55
20641287-0	2004	(64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) (64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) ((64)Cu-WT4351) is a (64)Cu-peptide-PNA-peptide chimera that was developed as a gene expression agent for positron emission tomography (PET) imaging of pancreatic cancer (1, 2).	Lysine	77-80	KRAS proto-oncogene, GTPase	Homo sapiens	58-62
20641287-0	2004	(64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) (64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) ((64)Cu-WT4351) is a (64)Cu-peptide-PNA-peptide chimera that was developed as a gene expression agent for positron emission tomography (PET) imaging of pancreatic cancer (1, 2).	Lysine	77-80	KRAS proto-oncogene, GTPase	Homo sapiens	144-148
20641287-0	2004	(64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) (64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) ((64)Cu-WT4351) is a (64)Cu-peptide-PNA-peptide chimera that was developed as a gene expression agent for positron emission tomography (PET) imaging of pancreatic cancer (1, 2).	Lysine	163-166	KRAS proto-oncogene, GTPase	Homo sapiens	58-62
20641287-0	2004	(64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) (64)Cu-N,N"-Bis(S-benzoyl-thioglycoloyl)diaminopropanoate-KRAS-PNA-d(Cys-Ser-Lys-Cys) ((64)Cu-WT4351) is a (64)Cu-peptide-PNA-peptide chimera that was developed as a gene expression agent for positron emission tomography (PET) imaging of pancreatic cancer (1, 2).	Lysine	163-166	KRAS proto-oncogene, GTPase	Homo sapiens	144-148
18078308-3	2008	Because the intestinal absorption of GLP-1 is restricted by its natural characteristics, we developed a series of GLP-1 analogues via the site-specific conjugation of biotin-NHS and/or of biotin-poly(ethylene glycol)-NHS at Lys 26 and Lys 34 of GLP-1 (7-36), respectively, in order to improve oral delivery.	Lysine	224-227	glucagon	Rattus norvegicus	114-119
18078308-3	2008	Because the intestinal absorption of GLP-1 is restricted by its natural characteristics, we developed a series of GLP-1 analogues via the site-specific conjugation of biotin-NHS and/or of biotin-poly(ethylene glycol)-NHS at Lys 26 and Lys 34 of GLP-1 (7-36), respectively, in order to improve oral delivery.	Lysine	224-227	glucagon	Rattus norvegicus	114-119
18078308-3	2008	Because the intestinal absorption of GLP-1 is restricted by its natural characteristics, we developed a series of GLP-1 analogues via the site-specific conjugation of biotin-NHS and/or of biotin-poly(ethylene glycol)-NHS at Lys 26 and Lys 34 of GLP-1 (7-36), respectively, in order to improve oral delivery.	Lysine	235-238	glucagon	Rattus norvegicus	114-119
18078308-3	2008	Because the intestinal absorption of GLP-1 is restricted by its natural characteristics, we developed a series of GLP-1 analogues via the site-specific conjugation of biotin-NHS and/or of biotin-poly(ethylene glycol)-NHS at Lys 26 and Lys 34 of GLP-1 (7-36), respectively, in order to improve oral delivery.	Lysine	235-238	glucagon	Rattus norvegicus	114-119
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Lysine	116-122	solute carrier family 7 member 1	Homo sapiens	47-80
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Lysine	116-122	solute carrier family 7 member 1	Homo sapiens	82-86
18093184-0	2008	Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process.	Lysine	75-78	Rac family small GTPase 1	Homo sapiens	10-14
18093184-4	2008	Mutational analysis of all lysine residues in Rac1 revealed that the major target site for Rac1 ubiquitination is Lys147, a solvent-accessible residue that has a similar conformation in Rac1b.	Lysine	27-33	Rac family small GTPase 1	Homo sapiens	46-50
18093184-4	2008	Mutational analysis of all lysine residues in Rac1 revealed that the major target site for Rac1 ubiquitination is Lys147, a solvent-accessible residue that has a similar conformation in Rac1b.	Lysine	27-33	Rac family small GTPase 1	Homo sapiens	91-95
18178771-0	2008	Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response.	Lysine	27-33	ubiquitin E2 	Arabidopsis thaliana	12-17
20641798-19	2004	(1) showed that the kidney uptake of a rhenium cyclized DOTA-alpha-MSH analog [DOTA-Re(Arg(11))CCMSH] could be considerably reduced and tumor uptake could be enhanced significantly by substitution the Lys(11) residue with Arg(11) in order to delocalize the charge of the Lys(11) residue.	Lysine	201-204	msh homeobox 1	Mus musculus	67-70
20641798-19	2004	(1) showed that the kidney uptake of a rhenium cyclized DOTA-alpha-MSH analog [DOTA-Re(Arg(11))CCMSH] could be considerably reduced and tumor uptake could be enhanced significantly by substitution the Lys(11) residue with Arg(11) in order to delocalize the charge of the Lys(11) residue.	Lysine	271-274	msh homeobox 1	Mus musculus	67-70
17891388-0	2007	Direct production of L-lysine from raw corn starch by Corynebacterium glutamicum secreting Streptococcus bovis alpha-amylase using cspB promoter and signal sequence.	Lysine	21-29	alpha-amylase	Zea mays	111-124
17972021-6	2007	Cells exposed to hypoxia generate reactive oxygen species which activate PKC zeta which in turn phosphorylates the Na,K-ATPase at the Ser18 residue in the N-terminus of the alpha1-subunit leading the ubiquitination of any of the four lysines (K16, K17, K19, K20) adjacent to the Ser18 residue.	Lysine	234-241	protein kinase C zeta	Homo sapiens	73-81
18042460-2	2007	Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark.	Lysine	107-113	lysine demethylase 4A	Homo sapiens	38-44
17985933-9	2007	Residues Lys 7 and Arg 5 play important roles in the interaction with MEK5 PB1.	Lysine	9-12	submaxillary gland androgen regulated protein 3A	Homo sapiens	75-78
17932512-5	2007	Functional analyses in Drosophila show that the MBT domain of Scm and its methyl-lysine-binding activity are required for repression of Hox genes.	Lysine	81-87	Sex comb on midleg	Drosophila melanogaster	62-65
17760872-5	2007	We identified CD44 expression in retinal ganglion cells and when these neurons were plated on poly-l-lysine 3% of them initiated axon growth, on OPN 15%, on laminin-111 (1x) 41%, on laminin-111 (0.5x) 56%, and on a mixture of OPN and laminin (1x) 67% of neurons generated axon growth.	Lysine	94-107	CD44 molecule (Indian blood group)	Homo sapiens	14-18
17726015-2	2007	Previous investigations have established that solvent-exposed, charged residues of the FXa alpha-helix 163-170 (h163-170), Arg(165) and Lys(169), participate in its binding to FVa.	Lysine	136-139	coagulation factor X	Homo sapiens	87-90
17675297-5	2007	Recombinant forms of Pellino1 and Pellino2 and both spliced variants of Pellino3 are shown in an in vitro ubiquitination assay to be E3 ligases that catalyze Lys(63)-linked polyubiquitination, with Pellino3 exhibiting the greatest ligase activity.	Lysine	158-161	pellino E3 ubiquitin protein ligase 1	Homo sapiens	21-29
17846165-0	2007	The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating.	Lysine	24-30	Charcot-Leyden crystal galectin	Homo sapiens	66-69
17805301-7	2007	Phosphorylated TORC2 was degraded by the 26S proteasome during re-feeding through an association with COP1, a substrate receptor for an E3 ligase complex that promoted TORC2 ubiquitination at Lys 628.	Lysine	192-195	COP1, E3 ubiquitin ligase	Mus musculus	102-106
17623650-3	2007	We identified Glu-353 and Lys-355 in repeat 11 as essential for binding, and the synthetic peptide RLDGNEIKR, including Glu-353 and Lys-355, inhibits the binding of fibromodulin to collagen in vitro.	Lysine	26-29	fibromodulin	Homo sapiens	165-177
17623650-3	2007	We identified Glu-353 and Lys-355 in repeat 11 as essential for binding, and the synthetic peptide RLDGNEIKR, including Glu-353 and Lys-355, inhibits the binding of fibromodulin to collagen in vitro.	Lysine	132-135	fibromodulin	Homo sapiens	165-177
17623650-6	2007	The collagen-binding Glu-353 and Lys-355 residues in fibromodulin are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat, which resembles the location of interacting residues in other leucine-rich repeat proteins, e.g. decorin.	Lysine	33-36	fibromodulin	Homo sapiens	53-65
17706197-3	2007	The mto2 strains exhibited significant reduction in the aminoacylation of tRNA(Lys), tRNA(Leu) but almost no effect in those of tRNA(His).	Lysine	79-82	tRNA-5-taurinomethyluridine 2-sulfurtransferase	Saccharomyces cerevisiae S288C	4-8
17496029-1	2007	In the cytochrome c-551 family, the heme 17-propionate caboxylate group is always hydrogen bonded to an invariant Trp-56 and conserved residues (His and Arg mainly, Lys occasionally) at position 47.	Lysine	165-168	cytochrome c3 family protein	Pseudomonas stutzeri	7-19
17555508-8	2007	RESULTS: Sequence analysis revealed a novel de novo heterozygous mutation at codon 551 (AGG--&gt;AAG), predicting a change of arginine to lysine (R551K) and a known heterozygous polymorphism (A986S) on the same allele, which was inherited from the father.	Lysine	138-144	N-methylpurine DNA glycosylase	Homo sapiens	97-100
17691833-6	2007	The HTB9-variant has acetylation sites at lysines 6, 11, 27, 32, 38, and 39, while Lys-145 can be ubiquitinated.	Lysine	42-49	Histone superfamily protein	Arabidopsis thaliana	4-8
17691833-6	2007	The HTB9-variant has acetylation sites at lysines 6, 11, 27, 32, 38, and 39, while Lys-145 can be ubiquitinated.	Lysine	83-86	Histone superfamily protein	Arabidopsis thaliana	4-8
17617175-4	2007	To elucidate the relationship between these biosynthetic branches, we crossed two lines of transgenic tobacco plants: one that overexpresses the feedback-insensitive bacterial enzyme dihydrodipicolinate synthase (DHPS) and contains a significantly higher level of lysine, and a second that overexpresses Arabidopsis cystathionine gamma-synthase (AtCGS), the first unique enzyme of methionine biosynthesis.	Lysine	264-270	4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic	Nicotiana tabacum	183-211
17719542-5	2007	In addition, hCAS/CSE1L silencing leads to increased methylation of histone H3 lysine 27 within the PIG3 gene.	Lysine	79-85	tumor protein p53 inducible protein 3	Homo sapiens	100-104
17585876-3	2007	In this study, we show that E1AF is sumoylated at four lysine residues, both in vivo and in vitro.	Lysine	55-61	ETS variant transcription factor 4	Homo sapiens	28-32
17585876-4	2007	Replacement of these lysines by arginine enhanced the transcriptional activity of E1AF, suggesting that sumoylation negatively regulates E1AF activity.	Lysine	21-28	ETS variant transcription factor 4	Homo sapiens	82-86
17585876-4	2007	Replacement of these lysines by arginine enhanced the transcriptional activity of E1AF, suggesting that sumoylation negatively regulates E1AF activity.	Lysine	21-28	ETS variant transcription factor 4	Homo sapiens	137-141
17687328-0	2007	Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.	Lysine	39-45	PHD finger protein 21A	Homo sapiens	54-59
17687328-0	2007	Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.	Lysine	39-45	lysine demethylase 1A	Homo sapiens	63-67
17687328-2	2007	LSD1 is a lysine-specific histone demethylase that represses transcription by demethylating histone H3 on lysine 4 (ref.	Lysine	10-16	lysine demethylase 1A	Homo sapiens	0-4
17602667-3	2007	We demonstrated that the probe reacted specifically with the lysine residue at the nucleotide-binding site of two purified adenosine nucleotide-binding proteins, Escherichia coli recombinase A (RecA) and Saccharomyces cerevisiae alcohol dehydrogenase-I (YADH-I).	Lysine	61-67	RAD51 recombinase	Homo sapiens	194-198
17602667-4	2007	A single conjugate peptide with a specifically labeled lysine residue was identified, by using LC-MS/MS, from the tryptic digestion mixture of the reaction products of the nucleotide analogue with RecA or YADH-I.	Lysine	55-61	RAD51 recombinase	Homo sapiens	197-201
17671180-5	2007	We also found that MTA1 acetylated on Lys(626) interacted with p300 histone acetyltransferase, and that acetylated MTA1 was recruited to the Pax5 promoter to stimulate Pax5 transcription.	Lysine	38-41	E1A binding protein p300	Mus musculus	63-67
17543536-5	2007	The technique was subsequently applied to a gel-derived sample of cytokeratin-8 (CK8) shown to contain acetylated lysine residues by Western blot analysis.	Lysine	114-120	keratin 8	Homo sapiens	66-79
17543536-5	2007	The technique was subsequently applied to a gel-derived sample of cytokeratin-8 (CK8) shown to contain acetylated lysine residues by Western blot analysis.	Lysine	114-120	keratin 8	Homo sapiens	81-84
17635959-12	2007	ATP reduces GLUT1 lysine covalent modification by sulfo-NHS-LC-biotin by 40%.	Lysine	18-24	solute carrier family 2 member 1	Homo sapiens	12-17
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Lysine	46-49	PDZ domain containing 1	Homo sapiens	144-149
17390218-13	2007	Thus, carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.	Lysine	46-49	PDZ domain containing 1	Homo sapiens	150-155
17562869-2	2007	In in vitro experiments with single-lysine-containing Cdc34 mutant proteins of Saccharomyces cerevisiae, we found that the SCF-mediated stimulation of autoubiquitination is limited to specific N-terminal lysines modified via an intermolecular mechanism.	Lysine	36-42	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	54-59
17562869-4	2007	Unlike autoubiquitination of the C-terminal lysines, which has no functional consequence, autoubiquitination of the N-terminal lysines inhibits Cdc34.	Lysine	127-134	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	144-149
17662948-5	2007	Mutation of two specific lysine residues in the C-terminal region of Pax3 reduced the extent of its monoubiquitination and susceptibility to proteasomal degradation, whereas introduction of a key lysine into the C-terminal region of Pax7 rendered that protein susceptible to monoubiquitination and proteasomal degradation.	Lysine	25-31	paired box 7	Homo sapiens	233-237
17620408-6	2007	Despite a crucial function of Ring1B in establishing the chromosome-wide ubiquitination of histone H2A lysine 119 (H2AK119ub1) upon Xist expression in ES cells, the initiation of silencing by Xist is independent of Ring1B.	Lysine	103-109	H2A.B variant histone 2	Mus musculus	91-102
17620408-6	2007	Despite a crucial function of Ring1B in establishing the chromosome-wide ubiquitination of histone H2A lysine 119 (H2AK119ub1) upon Xist expression in ES cells, the initiation of silencing by Xist is independent of Ring1B.	Lysine	103-109	inactive X specific transcripts	Mus musculus	132-136
17632060-5	2007	These proteins display strikingly different but complementary enzymatic behaviors: Ubc4 supports the rapid monoubiquitination of multiple lysines on APC targets, while Ubc1 catalyzes K48-linked polyubiquitin chain assembly on preattached ubiquitins.	Lysine	138-145	E2 ubiquitin-conjugating protein UBC4	Saccharomyces cerevisiae S288C	83-87
17569509-4	2007	Lysine-specific demethylase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), thus repressing transcription.	Lysine	69-75	lysine demethylase 1A	Homo sapiens	0-29
17569509-4	2007	Lysine-specific demethylase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), thus repressing transcription.	Lysine	69-75	lysine demethylase 1A	Homo sapiens	31-35
17031472-0	2007	Concise preparation of N(alpha)-Fmoc-N(epsilon)-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide.	Lysine	62-68	BOC cell adhesion associated, oncogene regulated	Homo sapiens	49-52
17031472-1	2007	A concise preparation of N(alpha)-Fmoc-N(epsilon)-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide is described.	Lysine	64-70	BOC cell adhesion associated, oncogene regulated	Homo sapiens	51-54
17031472-3	2007	A peptide containing monomethylated lysine is successfully synthesized by incorporating N(alpha)-Fmoc-N(epsilon)-(Boc, methyl)-lysine as a building block via solid-phase peptide synthesis.	Lysine	36-42	BOC cell adhesion associated, oncogene regulated	Homo sapiens	114-117
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	115-118	ubiquitin protein ligase E3A	Homo sapiens	30-34
17426036-4	2007	However, the HECT domain E3s, E6AP and Nedd4, with the same E2, UbcH5, form homogeneous chains exclusively, either Lys(48) chains (E6AP) or Lys(63) chains (Nedd4).	Lysine	140-143	ubiquitin protein ligase E3A	Homo sapiens	30-34
17489562-0	2007	Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2).	Lysine	15-21	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	107-116
17489562-1	2007	The human ecto-ATPase (NTPDase 2) contains conserved motifs including five apyrase conserved regions (ACRs) and four conserved regions (CRs) as well as conserved lysine and arginine residues that are also present in other cell surface E-NTPDases.	Lysine	162-168	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	23-32
17434460-6	2007	A lysine to proline mutation was introduced into the TM2-TM3 linker region at position 281 (K281P) of the alpha1 GlyR.	Lysine	2-8	tropomyosin 3	Homo sapiens	57-60
17296765-10	2007	The greater Lys concentration improved ADG in phase 3 (628 vs. 589 g; P &lt; 0.001) and overall (465 vs. 441 g; P &lt; 0.001) compared with pigs fed the NRC-estimated Lys requirements.	Lysine	12-15	ADG	Sus scrofa	39-42
17296336-6	2007	In contrast, sample treatment by carboxypeptidase B, removing the carboxy-terminal lysine residues from the two heavy chains of the antibody, resulted in reduced charge heterogeneity eliminating the two most basic bands observed in IEF.	Lysine	83-89	carboxypeptidase B1	Homo sapiens	33-51
17485541-6	2007	Alanine substitutions for lysines 408 and 412 (K408A/K412A) in a putative nucleotide-binding site of muA abolished NTPase activity, further suggesting that NTPase activity is attributable to protein muA.	Lysine	26-33	inosine triphosphatase	Homo sapiens	115-121
17485541-6	2007	Alanine substitutions for lysines 408 and 412 (K408A/K412A) in a putative nucleotide-binding site of muA abolished NTPase activity, further suggesting that NTPase activity is attributable to protein muA.	Lysine	26-33	inosine triphosphatase	Homo sapiens	156-162
17371838-4	2007	In contrast, downregulation of Mdm2 by a small interfering RNA (siRNA) approach led to increased levels of p53 lacking phosphorylation at serine 15 and acetylation at lysine 382.	Lysine	167-173	MDM2 proto-oncogene	Homo sapiens	31-35
17371849-6	2007	Increased expression of Nppb and Nppa correlates with increased histone H4 acetylation and histone H3 lysine 4 methylation of promoter-proximal regions of these genes.	Lysine	102-108	natriuretic peptide A	Rattus norvegicus	33-37
17495026-2	2007	The CYLD gene encodes a deubiquitinating enzyme that removes Lys-63-linked ubiquitin chains from I kappa B kinase signaling components and thereby inhibits NF-kappaB pathway activation.	Lysine	61-64	CYLD lysine 63 deubiquitinase	Homo sapiens	4-8
17274762-0	2007	A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase.	Lysine	2-8	inositol polyphosphate multikinase	Solanum tuberosum	92-122
17274762-7	2007	Our data reveal a lysine accumulation phenotype in ScIpk2Delta yeast that is restored to a wild-type profile by expression of StIPMK, including restoration of the transcript profiles of lysine biosynthetic genes.	Lysine	18-24	inositol polyphosphate multikinase	Solanum tuberosum	126-132
17417874-6	2007	Activation of pro-KLK6 requires hydrolysis after a Lys residue; however, KLK6 exhibits 2 order of magnitude reduced affinity for hydrolysis after Lys versus Arg residues; therefore, the ability to autolytically activate has been called into question.	Lysine	146-149	kallikrein related peptidase 6	Homo sapiens	73-77
17314394-8	2007	Chromatin immunoprecipitation analyses of lysines K4, K9, and K27 of histone H3 on OCT4 and NANOG indicate that primary chromatin remodeling determinants are acetylation of H3K9 and demethylation of dimethylated H3K9.	Lysine	42-49	Nanog homeobox	Homo sapiens	92-97
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Lysine	42-48	Toll	Drosophila melanogaster	155-159
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Lysine	80-86	lecithin-cholesterol acyltransferase	Homo sapiens	231-268
17357073-6	2007	Of note, HDL cholesterol levels are associated with an amino acid substitution (lysine/asparagine) at codon 198 (rs5370) of endothelin-1 (EDN1) in a sex-specific manner, as well as with a SNP (rs2292318) located 7.7 kb upstream of lecithin cholesterol acyl-transferase (LCAT).	Lysine	80-86	lecithin-cholesterol acyltransferase	Homo sapiens	270-274
17251291-4	2007	A CXCR3 variant carrying the CXCR4 binding pocket was constructed by simultaneous lysine-to-alanine and serine-to-glutamate substitutions at positions 300 and 304 of the CXCR3 receptor.	Lysine	82-88	C-X-C motif chemokine receptor 4	Homo sapiens	29-34
17205979-5	2007	In a mass spectrometric analysis of mouse RARalpha expressed in insect cells, we identified a trimethylation site on Lys(347) in the ligand binding domain.	Lysine	117-120	retinoic acid receptor, alpha	Mus musculus	42-50
17320162-2	2007	BHC110/LSD1 was the first histone demethylase described to reverse dimethyl histone H3 lysine 4 (H3K4).	Lysine	87-93	lysine demethylase 1A	Homo sapiens	0-6
17320162-2	2007	BHC110/LSD1 was the first histone demethylase described to reverse dimethyl histone H3 lysine 4 (H3K4).	Lysine	87-93	lysine demethylase 1A	Homo sapiens	7-11
17218320-5	2007	Histone H3 acetylation and Lys-4 tri-methylation were specifically associated with IL-17 and IL-17F gene promoters in THi lineage.	Lysine	27-30	interleukin 17A	Homo sapiens	83-88
17342255-1	2007	Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitors of furin, a mammalian proprotein convertase.	Lysine	30-36	H1.0 linker histone	Homo sapiens	0-10
17328786-4	2007	In vivo studies in C57BL/6 mice showed that injection of DNA encoding ovalbumin (OVA) complexed to oxidized or reduced mannan-poly-L-lysine induced CD8 and CD4 T-cell responses as well as antibody responses leading to protection of mice from OVA+ tumours.	Lysine	126-139	CD4 antigen	Mus musculus	156-159
17381688-5	2007	Two of three animals were given GAS914, a poly-L-lysine derivative shown to bind to anti-Gal xenoantibodies and neutralize them.	Lysine	42-55	galanin and GMAP prepropeptide	Homo sapiens	89-92
17301242-4	2007	Here, we show that C/EBPbeta is acetylated by GCN5 and PCAF within a cluster of lysine residues between amino acids 98-102 and that this acetylation is strongly induced by glucocorticoid treatment.	Lysine	80-86	lysine acetyltransferase 2A	Homo sapiens	46-50
17114219-3	2007	In this study, we covalently labeled the N-terminal (Gly-1) and Lys-7 of melittin with an environment-sensitive fluorescent probe, the NBD group, to monitor the influence of negatively charged lipids and cholesterol on the organization and dynamics of membrane-bound melittin.	Lysine	64-67	melittin	Apis mellifera	73-81
17272722-0	2007	Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56.	Lysine	68-74	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	6-12
17272722-3	2007	Furthermore, we show that, as for Asf1p, Rtt109p is required for histone H3 acetylation on lysine 56 (K56) in vivo.	Lysine	91-97	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	41-48
17291071-2	2007	Light scattering experiments showed EC50 (lysine concentration at 50% DNA compaction) values of approximately 0.0036, 2, and 20 micromol/L, respectively, for PLL, Lys5, and Lys4 at 10 mM [Na+].	Lysine	42-48	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	163-167
17186026-4	2007	Here, we show that a marked change in the electrostatic properties of a specific region of Yfh1 surface - by substituting two or four acidic residues by lysine or alanine, respectively - impairs Fe-S cluster assembly, weakens the interaction between Yfh1 and Isu1, and increases oxidative damage.	Lysine	153-159	ferroxidase	Saccharomyces cerevisiae S288C	91-95
17011671-1	2007	As part of a drug delivery project, four aldehydes of the type Pam-Lys(Pam)-spacer-CO-CHO were synthesized to be included in targeting colloids.	Lysine	67-70	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	63-66
17011671-1	2007	As part of a drug delivery project, four aldehydes of the type Pam-Lys(Pam)-spacer-CO-CHO were synthesized to be included in targeting colloids.	Lysine	67-70	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	71-74
17140415-3	2007	We show that aspartate kinase 2 and aspartate kinase 3 are inhibited only by lysine, and that aspartate kinase 1 is inhibited in a synergistic manner by lysine and SAM.	Lysine	77-83	protein kinase 2B	Arabidopsis thaliana	23-54
17264065-1	2007	A new type of protein was found in Arabidopsis thaliana, PCaP1, which is rich in glutamate and lysine residues.	Lysine	95-101	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	57-62
17200769-3	2007	Our earlier work demonstrated a novel Ca (2+) -enhanced bivalent interaction between plasmin-cleaved FXa (FXa33/13) and plasminogen truncated at Lys78 (Lys-Pg).	Lysine	145-148	coagulation factor X	Homo sapiens	101-104
17200769-3	2007	Our earlier work demonstrated a novel Ca (2+) -enhanced bivalent interaction between plasmin-cleaved FXa (FXa33/13) and plasminogen truncated at Lys78 (Lys-Pg).	Lysine	145-148	coagulation factor X	Homo sapiens	106-114
17200769-8	2007	Only Lys-Pg demonstrated significant Ca (2+) -independent binding to FXa33/13.	Lysine	5-8	coagulation factor X	Homo sapiens	69-77
17200769-10	2007	The elastase-generated plasminogen fragment encompassing the angiostatin-like kringle domains 1 to 3 (K1 - 3) inhibited binding of FXa33/13 to Lys-Pg, whereas fragments corresponding to kringle 4- and kringle 5-protease domain had no effect.	Lysine	143-146	coagulation factor X	Homo sapiens	131-139
17200769-14	2007	These studies suggest that Ca (2+) -dependent and -independent binding of Lys-Pg to FXa33/13 are C-terminal lysine-dependent.	Lysine	74-77	coagulation factor X	Homo sapiens	84-92
17200769-14	2007	These studies suggest that Ca (2+) -dependent and -independent binding of Lys-Pg to FXa33/13 are C-terminal lysine-dependent.	Lysine	108-114	coagulation factor X	Homo sapiens	84-92
17077080-4	2006	Conjugation of SUMO-2/3 proteins is strongly enhanced by several different cellular stresses and occurs primarily on two lysines, Lys(523) and Lys(499).	Lysine	121-128	small ubiquitin like modifier 2	Homo sapiens	15-23
17077080-4	2006	Conjugation of SUMO-2/3 proteins is strongly enhanced by several different cellular stresses and occurs primarily on two lysines, Lys(523) and Lys(499).	Lysine	130-133	small ubiquitin like modifier 2	Homo sapiens	15-23
17077080-4	2006	Conjugation of SUMO-2/3 proteins is strongly enhanced by several different cellular stresses and occurs primarily on two lysines, Lys(523) and Lys(499).	Lysine	143-146	small ubiquitin like modifier 2	Homo sapiens	15-23
17157298-4	2006	In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4.	Lysine	145-151	inhibitor of growth family member 4	Homo sapiens	21-25
17083016-6	2006	An analysis of the multiple single-nucleotide polymorphisms in SP-A demonstrated that homozygosity for alleles encoding lysine (in 1A1) rather than glutamine (in 1A5) at amino acid 223 in the carbohydrate recognition domain was associated with an increased risk of meningococcal disease (OR, 6.7; 95% CI, 1.4-31.5).	Lysine	120-126	surfactant protein A2	Homo sapiens	63-67
17107999-6	2006	Strikingly, methylated lysine 27 of histone H3 (H3-K27), a mediator of Polycomb complex recruitment to target genes, stably associated with the EED complex during the maintenance phase of Hox gene repression.	Lysine	23-29	chromobox 2	Mus musculus	71-79
17107999-6	2006	Strikingly, methylated lysine 27 of histone H3 (H3-K27), a mediator of Polycomb complex recruitment to target genes, stably associated with the EED complex during the maintenance phase of Hox gene repression.	Lysine	23-29	embryonic ectoderm development	Homo sapiens	144-147
17138746-4	2006	The GLP-1 receptor affinity (50% inhibitory concentration [IC(50)] value) of [Lys(40)(Ahx-DTPA)NH(2)]exendin-4 as well as the GLP-1 receptor density in tumors and different organs of Rip1Tag2 mice were determined.	Lysine	78-81	glucagon-like peptide 1 receptor	Mus musculus	4-18
17138746-8	2006	RESULTS: The GLP-1 receptor affinity of [Lys(40)(Ahx-DTPA)NH(2)]exendin-4 was found to be 2.1 +/- 1.1 nmol/L (mean +/- SEM).	Lysine	41-44	glucagon-like peptide 1 receptor	Mus musculus	13-27
16987819-9	2006	The complex formed by LSD1 with histone deacetylases 1/2 may function as a "double-blade razor" that first eliminates the acetyl groups from acetylated Lys residues and then removes the methyl group from Lys4.	Lysine	152-155	lysine demethylase 1A	Homo sapiens	22-26
16996030-3	2006	By in vitro ubiquitylation assays, we have identified lysine 258 in the GAT domain as a major ubiquitylation site that resides adjacent to the ubiquitin-binding site.	Lysine	54-60	glycine-N-acyltransferase	Homo sapiens	72-75
16966324-7	2006	We identify lysine residues 50 and 383 as the SUMO acceptor sites in SnoN.	Lysine	12-18	SKI like proto-oncogene	Homo sapiens	69-73
16715135-7	2006	DNMT1 or DNMT3b knockout reduced dimethylated lysine-9 (diMe-H3K9) levels, but did not significantly affect dimethylated lysine-4 (diMe-H3K4) or acetylated lysine-9 (Ac-H3-K9) levels.	Lysine	46-52	DNA methyltransferase 1	Homo sapiens	0-5
17085686-10	2006	These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.	Lysine	59-62	histone acetyltransferase of the TAFII250 family 2	Arabidopsis thaliana	92-96
16828555-4	2006	Three well-conserved residues among SDR family which correspond to Ser-138, Tyr-151, and Lys-155 of 15-PGDH have been shown to participate in the catalytic reaction.	Lysine	89-92	carbonyl reductase 1	Homo sapiens	100-107
16964423-0	2006	Effects of lysine to arginine mutations in HIV-1 Vif on its expression and viral infectivity.	Lysine	11-17	Vif	Human immunodeficiency virus 1	49-52
16964423-2	2006	We examined the contribution of 16 lysines present in Vif (NL432 clone), which is composed of 192 amino acids (aa), to its expression within cells and to viral infectivity for non-permissive cells.	Lysine	35-42	Vif	Human immunodeficiency virus 1	54-57
16964423-4	2006	When all the lysines were changed to arginines, the mutant Vif was expressed in cells at much higher level than wt and was much more stable.	Lysine	13-20	Vif	Human immunodeficiency virus 1	59-62
16826604-10	2006	We also tried to investigate the effect of alpha-synuclein, a substrate of parkin and also forming Lysine 63-linked multiubiquitin chains.	Lysine	99-105	synuclein alpha	Rattus norvegicus	43-58
16981007-6	2006	An increase in histone H3/H4 acetylation and histone H3 lysine 4 (Lys4) methylation within the Hoxa7 and Hoxa9 promoters provides an epigenetic mechanism by which this overexpression occurs in vivo and an etiologic role for MLL PTD gain of function in the genesis of AML.	Lysine	56-62	homeobox A9	Mus musculus	105-110
16899318-3	2006	In this study, we examined the feasibility of FITC-labeled poly-L-lysine-CF3 (PLK-CF3) using glial cells.	Lysine	59-72	polo like kinase 1	Mus musculus	78-81
16936264-5	2006	The generation of the anti-apoptotic signal on binding of TNF-alpha to the TNF receptor (TNFR)1 has been shown to be associated with the recruitment of TRAF2 to the TNFR1 in a process that requires ubiquitination of TRAF2 with lysine-63-linked polyubiquitin chains.	Lysine	227-233	TNF receptor associated factor 2	Homo sapiens	152-157
16936264-5	2006	The generation of the anti-apoptotic signal on binding of TNF-alpha to the TNF receptor (TNFR)1 has been shown to be associated with the recruitment of TRAF2 to the TNFR1 in a process that requires ubiquitination of TRAF2 with lysine-63-linked polyubiquitin chains.	Lysine	227-233	TNF receptor associated factor 2	Homo sapiens	216-221
16906149-9	2006	Activity of STIM1 requires an ERM domain, which mediates the selective binding of STIM1 to TRPC1, 2 and 4, but not to TRPC3, 6 or 7, and a cationic lysine-rich region, which is essential for gating of TRPC1.	Lysine	148-154	transient receptor potential cation channel subfamily C member 1	Homo sapiens	91-105
16906149-9	2006	Activity of STIM1 requires an ERM domain, which mediates the selective binding of STIM1 to TRPC1, 2 and 4, but not to TRPC3, 6 or 7, and a cationic lysine-rich region, which is essential for gating of TRPC1.	Lysine	148-154	transient receptor potential cation channel subfamily C member 1	Homo sapiens	91-96
17117362-1	2006	Recent reports identified DGAT1 (EC 2.3.1.20) harboring a lysine to alanine substitution (K232A) as a candidate gene with a strong effect on milk production traits.	Lysine	58-64	diacylglycerol O-acyltransferase 1	Bos taurus	26-31
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Lysine	13-19	survivin	Saccharomyces cerevisiae S288C	205-209
16568089-6	2006	Lysine 96, the first lysine in the amino-terminal region of Sam68, was found to be the major SUMO acceptor site.	Lysine	0-6	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	60-65
16568089-6	2006	Lysine 96, the first lysine in the amino-terminal region of Sam68, was found to be the major SUMO acceptor site.	Lysine	21-27	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	60-65
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Lysine	30-36	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	73-78
16882982-7	2006	Our analyses of mutants that lack the PcG histone methyltransferase (HMTase) E(z) or the trxG HMTase Ash1 provide strong evidence that differential histone lysine trimethylation at the promoter and in the coding region confers transcriptional ON and OFF states of Ubx.	Lysine	156-162	trithorax	Drosophila melanogaster	89-93
16840633-6	2006	The lysine variant of the DGAT1 K232A mutation showed significant effects for most of the milk production traits.	Lysine	4-10	diacylglycerol O-acyltransferase 1	Bos taurus	26-31
16877706-2	2006	All Lon proteases contain an ATPase domain belonging to the AAA(+) superfamily of molecular machines and a proteolytic domain with a serine-lysine catalytic dyad.	Lysine	140-146	putative ATP-dependent Lon protease	Escherichia coli	4-7
16732292-0	2006	The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.	Lysine	71-77	lysine demethylase 4A	Homo sapiens	30-36
16732292-0	2006	The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.	Lysine	84-90	lysine demethylase 4A	Homo sapiens	30-36
16732292-3	2006	Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain.	Lysine	0-6	malic enzyme 1	Homo sapiens	71-74
16732292-3	2006	Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain.	Lysine	0-6	malic enzyme 3	Homo sapiens	97-100
16713291-9	2006	Interestingly, next to in the binding interface expected lysines, K89 and K97, two from the crystal structure data unexpected lysines, K81 and K76, were observed to become less exposed upon Im9 binding.	Lysine	126-133	keratin 81	Homo sapiens	135-138
16612335-2	2006	Genetic analyses of two patients revealed deletion of a single Lys residue (K224) located within the complement regulatory region in domain 4 of Factor H.	Lysine	63-66	complement factor H	Homo sapiens	145-153
16497731-6	2006	PTMs identified in murine and bovine adiponectin include hydroxylation of multiple conserved proline and lysine residues and glycosylation of hydroxylysines.	Lysine	105-111	adiponectin, C1Q and collagen domain containing	Bos taurus	37-48
16799558-2	2006	LSD1, the first known lysine-specific demethylase, selectively removes monomethyl and dimethyl, but not trimethyl modifications of Lys4 or Lys9 of histone-3.	Lysine	22-28	lysine demethylase 1A	Homo sapiens	0-4
16830863-2	2006	The Lys, CP, and ME concentrations were fluctuated in Exp 1 by varying corn and soybean meal concentrations.	Lysine	4-7	alpha expansin 1	Zea mays	54-59
16613842-13	2006	Consequently, the PH module is an obligatory, positive regulator of DKF-1 activity that is compromised by mutation of Lys(298) or Trp(396).	Lysine	118-121	Serine/threonine-protein kinase dkf-1	Caenorhabditis elegans	68-73
16627470-0	2006	An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.	Lysine	89-95	hemoglobin, beta adult minor chain	Mus musculus	120-125
16627470-3	2006	We investigated the effect on expression and function of the Lys --&gt; Met mutation in mouse alpha1(K278M), beta2(K274M), and gamma2(K289M) subunits.	Lysine	61-64	hemoglobin, beta adult minor chain	Mus musculus	109-114
16627470-14	2006	Moreover, the conserved TM2-3 loop lysine has an asymmetric function in different GABAA subunits.	Lysine	35-41	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	82-87
16827654-15	2006	This can be explained by competition of alpha(2)-antiplasmin and monoclonal antibody IV-Ic for the lysine-binding sites of plasminogen and inhibition of the active center in activated complex plasminogen*-mAB IV-Ic.	Lysine	99-105	serpin family F member 2	Homo sapiens	40-60
16793513-1	2006	Demethylation of histone H3 lysine 4 is carried out by BHC110/LSD1, an enzyme with close homology to monoamine oxidases (MAO).	Lysine	28-34	lysine demethylase 1A	Homo sapiens	55-61
16793513-1	2006	Demethylation of histone H3 lysine 4 is carried out by BHC110/LSD1, an enzyme with close homology to monoamine oxidases (MAO).	Lysine	28-34	lysine demethylase 1A	Homo sapiens	62-66
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	basic helix-loop-helix family member e41	Homo sapiens	70-74
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	basic helix-loop-helix family member e41	Homo sapiens	124-128
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	basic helix-loop-helix family member e41	Homo sapiens	124-128
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Lysine	63-66	basic helix-loop-helix family member e41	Homo sapiens	124-128
16551626-4	2006	In the present study, the role of specific lysine residues in the alpha-helical region of IFABP was directly examined.	Lysine	43-49	fatty acid binding protein 2	Rattus norvegicus	90-95
16551626-5	2006	A series of point mutants in rat IFABP was engineered in which the lysine positive charges in this domain were eliminated or reversed.	Lysine	67-73	fatty acid binding protein 2	Rattus norvegicus	33-38
16601153-0	2006	Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A.	Lysine	26-32	lysine demethylase 4A	Homo sapiens	77-83
16702384-8	2006	The combination genotypes of two polymorphisms revealed the clear effect of the ADH2 Arg allele among those with ALDH2 Glu/Lys in both sexes (P(trend) = 0.007 for men and 0.024 for women).	Lysine	123-126	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	80-84
16784457-2	2006	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of His(6) and the epsilon-amino group of Lys(10) lead to high-affinity, selective human melanocortin receptor-1 and -5 (hMC1R and hMC5R) antagonists.	Lysine	121-124	melanocortin 5 receptor	Homo sapiens	210-215
16731766-4	2006	The fluorinated lysine derivative Boc-Lys-(Tfa)-OH (BLT) was investigated as a (19)F MRS molecular marker of HDAC activity together with (31)P MRS of endogenous metabolites.	Lysine	16-22	histone deacetylase 9	Homo sapiens	109-113
16584196-1	2006	The kinetics and thermodynamics of the alkaline and acid conformational transitions of a Lys 79 --&gt; Ala/Asn 52 --&gt; Gly (A79G52) variant of iso-1-cytochrome c are studied.	Lysine	89-92	eukaryotic translation initiation factor 1	Homo sapiens	145-150
16584196-6	2006	This pK(H) is low for alkaline conformers involving lysine-heme ligation but is consistent with the pK(a) of the highest of three ionizable groups which modulate formation of the histidine-heme alkaline conformer of a His 73 variant of iso-1-cytochrome c [Martinez, R. E., and Bowler, B. E. (2004) J.	Lysine	52-58	eukaryotic translation initiation factor 1	Homo sapiens	236-241
16421094-7	2006	Mutation of the conserved lysine 33 to arginine in this motif abolished SUMOylation of phosducin, indicating that SUMO is attached to lysine 33 of phosducin.	Lysine	26-32	phosducin	Homo sapiens	87-96
16421094-7	2006	Mutation of the conserved lysine 33 to arginine in this motif abolished SUMOylation of phosducin, indicating that SUMO is attached to lysine 33 of phosducin.	Lysine	26-32	phosducin	Homo sapiens	147-156
16543223-7	2006	In support of our genome-wide analysis, we found that the acetylatable lysines of Htz1 are required for its full deposition during nucleosome reassembly upon repression of PHO5.	Lysine	71-78	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	172-176
16489122-6	2006	IAA8, IAA9, and IAA28 contain domain II and a conserved Lys, but they were degraded more slowly than previously characterized family members when expressed as LUC fusions, suggesting that sequences outside domain II influence proteolysis.	Lysine	56-59	indoleacetic acid-induced protein 8	Arabidopsis thaliana	0-4
16489122-6	2006	IAA8, IAA9, and IAA28 contain domain II and a conserved Lys, but they were degraded more slowly than previously characterized family members when expressed as LUC fusions, suggesting that sequences outside domain II influence proteolysis.	Lysine	56-59	indole-3-acetic acid inducible 9	Arabidopsis thaliana	6-10
16356933-3	2006	We recently showed that human MEF2D (myocyte enhancer factor 2D) is sumoylated on Lys-439.	Lysine	82-85	myocyte enhancer factor 2D	Homo sapiens	30-35
16356933-3	2006	We recently showed that human MEF2D (myocyte enhancer factor 2D) is sumoylated on Lys-439.	Lysine	82-85	myocyte enhancer factor 2D	Homo sapiens	37-63
16356933-5	2006	Here we present [corrected] several lines of evidence to demonstrate that Ser-444 of MEF2D is required for sumoylation of Lys-439.	Lysine	122-125	myocyte enhancer factor 2D	Homo sapiens	85-90
16158053-2	2006	Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3.	Lysine	121-127	DIRAS family GTPase 3	Homo sapiens	16-20
16388603-3	2006	Sir2 proteins (sirtuins) catalyze the chemical conversion of NAD+ and acetylated lysine to nicotinamide, deacetylated lysine, and 2"-O-acetyl-ADP-ribose (OAADPr).	Lysine	81-87	sirtuin 1	Homo sapiens	0-4
16388603-3	2006	Sir2 proteins (sirtuins) catalyze the chemical conversion of NAD+ and acetylated lysine to nicotinamide, deacetylated lysine, and 2"-O-acetyl-ADP-ribose (OAADPr).	Lysine	118-124	sirtuin 1	Homo sapiens	0-4
15930150-1	2006	In the present study, we have demonstrated functional interaction between Ste20-related proline-alanine-rich kinase (SPAK), WNK4 [with no lysine (K)], and the widely expressed Na+-K+-2Cl- cotransporter type 1 (NKCC1).	Lysine	138-144	oxidative stress responsive kinase 1 L homeolog	Xenopus laevis	74-115
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	73-79	ATP binding cassette subfamily A member 1	Homo sapiens	278-283
16495141-5	2006	The dose-dependent acetoacetylation of an increasing proportion of apoAI lysine residues demonstrated that cholesterol acceptor activity was more sensitive to this modification than lipid binding activity, suggesting that apoAI lysine positive charges play an important role in ABCA1 mediated lipid efflux beyond the role needed to maintain alpha-helical content and lipid binding activity.	Lysine	228-234	ATP binding cassette subfamily A member 1	Homo sapiens	278-283
26718042-2	2006	The first lysine specific histone demethylase (LSD1) has been recently discovered, whichrules out the hypothesis that histone methylation represents a permanent epigenetic mark.	Lysine	10-16	lysine demethylase 1A	Homo sapiens	47-51
16963494-4	2006	We show that dG9a shares the structural organization of mammalian G9a, and that it is a multi-catalytic histone methyltransferase with specificity not only for lysines 9 and 27 on H3 but also for H4.	Lysine	160-167	G9a	Drosophila melanogaster	13-17
16963494-4	2006	We show that dG9a shares the structural organization of mammalian G9a, and that it is a multi-catalytic histone methyltransferase with specificity not only for lysines 9 and 27 on H3 but also for H4.	Lysine	160-167	euchromatic histone lysine methyltransferase 2	Homo sapiens	14-17
16263726-2	2005	In the current study, we identify human CHD1, an ATP-dependent chromatin remodeling protein, as a factor that directly and selectively recognizes histone H3 methylated on lysine 4.	Lysine	171-177	bromodomain adjacent to zinc finger domain 1A	Homo sapiens	49-91
16337200-3	2005	hK8 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Lysine	68-71	keratin 8	Homo sapiens	0-3
16360039-0	2005	Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.	Lysine	13-19	KIT ligand	Homo sapiens	100-103
16360039-0	2005	Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.	Lysine	13-19	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	104-109
16321608-2	2005	It was found that, besides the sulfhydryl reagents NEM, MTSEA, p-hydroxymercuribenzoate, diamide also the lysine reagents PLP, DIDS, SITS, the carboxyl reagents WRK, EDC and the arginine reagent methylglyoxal inhibited the carrier.	Lysine	106-112	proteolipid protein 1	Homo sapiens	122-125
16322459-5	2005	Lys(63) de-ubiquitination mediated by hFAM is required for the dissociation of Survivin from centromeres, whereas Lys(63) ubiquitination mediated by the ubiquitin binding protein Ufd1 is required for the association of Survivin with centromeres.	Lysine	0-3	ubiquitin specific peptidase 9 X-linked	Homo sapiens	38-42
16245011-4	2005	The ADGF proteins share a novel amino acid motif, "MPKG," within which the proline and lysine residues are also conserved in the ADAL and ADA subfamilies.	Lysine	87-93	adenosine deaminase	Homo sapiens	129-132
16306600-0	2005	Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection.	Lysine	75-82	CD8a molecule	Homo sapiens	136-139
16247734-7	2005	NF-L protein, Hsc70, alpha-tubulin fragments, beta-actin, and brain-type creatine kinase were identified as putative lysine-methylated proteins in mouse brain.	Lysine	117-123	actin, beta	Mus musculus	46-88
16307923-1	2005	In yeast, histone H2B monoubiquitination is a cotranscriptional event regulating histone H3 methylation at lysines 4 and 79.	Lysine	107-114	histone H2B	Saccharomyces cerevisiae S288C	10-21
16127177-3	2005	Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys(9) of histone H3 (K9/H3).	Lysine	110-113	keratin 9	Homo sapiens	132-137
16127177-4	2005	The linker histone H1.4 is methylated on Lys(26) (K26/H1.4), but the role of this methylation in downstream events remains unknown.	Lysine	41-44	H1.4 linker histone, cluster member	Homo sapiens	11-23
16127177-4	2005	The linker histone H1.4 is methylated on Lys(26) (K26/H1.4), but the role of this methylation in downstream events remains unknown.	Lysine	41-44	H1.4 linker histone, cluster member	Homo sapiens	19-23
16285929-2	2005	We now show that the DM1 insulator is maintained in a local heterochromatin context: an antisense transcript emanating from the adjacent SIX5 regulatory region extends into the insulator element and is converted into 21 nucleotide (nt) fragments with associated regional histone H3 lysine 9 (H3-K9) methylation and HP1gamma recruitment that is embedded within a region of euchromatin-associated H3 lysine 4 (H3-K4) methylation.	Lysine	282-288	SIX homeobox 5	Homo sapiens	137-141
16262255-4	2005	Little is known about how SCF(Skp2) recruits its substrates and selects particular acceptor lysine residues for ubiquitination.	Lysine	92-98	KIT ligand	Homo sapiens	26-29
16185272-5	2005	This permits classifying all HLA-C alleles into two functional groups: asparagine (N80) or lysine (K80) carrying alleles.	Lysine	91-97	major histocompatibility complex, class I, C	Homo sapiens	29-34
16127432-2	2005	Neddylation, the process that conjugates the ubiquitin-like polypeptide Nedd8 to the conserved lysines of cullins, is essential for in vivo cullin-organized E3 activities.	Lysine	95-102	cullin 1	Canis lupus familiaris	106-113
15935490-8	2005	In particular, [(pF)Phe(4), Aib(7), Aib(11), Arg(14), Lys(15)] N/OFQ-NH(2) was found to be a highly potent agonist with pK(i)=10.78 in binding studies and pEC(50)=9.37 in mouse vas deferens assay.	Lysine	54-57	prepronociceptin	Mus musculus	63-68
15935490-10	2005	[Nphe(1), (pF)Phe(4), Aib(7), Aib(11), Arg(14), Lys(15)] N/OFQ-NH(2) was the best antagonist with pA(2)=8.39 and showed high binding affinity with pK(i)=9.99.	Lysine	48-51	prepronociceptin	Mus musculus	57-62
16079795-7	2005	LSD1 relieves repressive histone marks by demethylation of histone H3 at lysine 9 (H3-K9), thereby leading to de-repression of androgen receptor target genes.	Lysine	73-79	lysine demethylase 1A	Homo sapiens	0-4
16135789-4	2005	Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha).	Lysine	22-28	E1A binding protein p300	Mus musculus	62-66
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Lysine	141-147	E1A binding protein p300	Mus musculus	105-109
16085123-1	2005	Lysyl oxidase (LOX) is a copper- and lysyl-tyrosyl cofactor containing amine oxidase that has been known to play a critical role in the catalysis of lysine-derived crosslinks in extracellular matrix (ECM) proteins in the dermis.	Lysine	149-155	lysyl oxidase	Homo sapiens	0-13
16085123-1	2005	Lysyl oxidase (LOX) is a copper- and lysyl-tyrosyl cofactor containing amine oxidase that has been known to play a critical role in the catalysis of lysine-derived crosslinks in extracellular matrix (ECM) proteins in the dermis.	Lysine	149-155	lysyl oxidase	Homo sapiens	15-18
16846069-7	2005	The obtained results are explained by the influence of the inhibitor on formation of the triple complex between plasminogen, tissue activator and fibrin, and competition of the alpha-2-antiplasmin for lysine-binding sites of tissue activator kringle 2 or for binding sites of the activator on fibrin.	Lysine	201-207	serpin family F member 2	Homo sapiens	177-196
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Lysine	72-78	hepsin	Homo sapiens	0-6
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Lysine	150-156	hepsin	Homo sapiens	0-6
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Lysine	150-156	hepsin	Homo sapiens	0-6
15958389-3	2005	Here we demonstrate that human HIPK2 is small ubiquitin-related modifier-1 (SUMO-1)-modified in vitro and in vivo at lysine residue 25, a SUMO consensus modification motif conserved in human and mouse HIPK family proteins.	Lysine	117-123	homeodomain interacting protein kinase 2	Homo sapiens	31-36
15958389-6	2005	HIPK2 with a mutated SUMO acceptor lysine residue was refractory to inhibition of HIPK2-mediated JNK activation by SUMO-1.	Lysine	35-41	homeodomain interacting protein kinase 2	Homo sapiens	0-5
15964548-5	2005	RIZ1 is also a histone methyltransferase and methylates lysine 9 in histone H3.	Lysine	56-62	PR/SET domain 2	Homo sapiens	0-4
16042383-0	2005	Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex.	Lysine	90-96	coagulation factor X	Homo sapiens	65-74
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Lysine	79-82	coagulation factor X	Homo sapiens	58-61
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Lysine	95-98	coagulation factor X	Homo sapiens	58-61
16094446-6	2005	Dimethylation of histone H3 lysine 9 and binding of methyl-CpG binding proteins are common and essential in MGMT-silenced cells.	Lysine	28-34	O-6-methylguanine-DNA methyltransferase	Homo sapiens	108-112
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	112-115	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	112-115	insulin like growth factor 1 receptor	Homo sapiens	633-639
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	131-134	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Lysine	131-134	insulin like growth factor 1 receptor	Homo sapiens	633-639
15937898-5	2005	In the latter cells, published cell cycle profiles of histone H4 acetylated at lysine 16 (H4AcK16) or dimethylated at lysine 20 (H4Me2K20) are disputed.	Lysine	79-85	H4 clustered histone 9	Homo sapiens	54-64
16008566-6	2005	In K562 erythroleukemic cells, alanine at position 17 in H1.2 was replaced by valine, and, in Raji B lymphoblastoid cells, lysine at position 173 in H1.4 was replaced by arginine.	Lysine	123-129	H1.4 linker histone, cluster member	Homo sapiens	149-153
15718415-5	2005	Using a new biochemical assay for measuring the carboxy-terminal cleavage activity, we purified from serum and plasma a peptidase that specifically removes the carboxy-terminal lysine from SDF-1alpha and identified it as carboxypeptidase N (CPN, also known as kininase I, arginine carboxypeptidase, and anaphylotoxin inactivator).	Lysine	177-183	carboxypeptidase N subunit 1	Homo sapiens	241-244
15718415-5	2005	Using a new biochemical assay for measuring the carboxy-terminal cleavage activity, we purified from serum and plasma a peptidase that specifically removes the carboxy-terminal lysine from SDF-1alpha and identified it as carboxypeptidase N (CPN, also known as kininase I, arginine carboxypeptidase, and anaphylotoxin inactivator).	Lysine	177-183	carboxypeptidase N subunit 1	Homo sapiens	260-270
15718415-5	2005	Using a new biochemical assay for measuring the carboxy-terminal cleavage activity, we purified from serum and plasma a peptidase that specifically removes the carboxy-terminal lysine from SDF-1alpha and identified it as carboxypeptidase N (CPN, also known as kininase I, arginine carboxypeptidase, and anaphylotoxin inactivator).	Lysine	177-183	carboxypeptidase N subunit 1	Homo sapiens	272-297
15718415-7	2005	Purified CPN effectively and specifically removes the carboxy-terminal lysine from SDF-1alpha and significantly reduces the chemokine"s biologic activity as a pre-B-cell growth factor and chemoattractant.	Lysine	71-77	carboxypeptidase N subunit 1	Homo sapiens	9-12
15896780-2	2005	Here we show that lysine 25 of HIPK2 is the major sumoylation site, both in vitro and in vivo, and that the sumoylation of this site occurs in a phosphorylation-dependent manner.	Lysine	18-24	homeodomain interacting protein kinase 2	Homo sapiens	31-36
15846369-6	2005	In agreement, mutation of three lysines in a putative heparin sulfate-binding motif, which is not part of the TNF fold, destroys interaction with HSPG, while binding to BCMA is unaffected.	Lysine	32-39	syndecan 2	Homo sapiens	146-150
16101009-8	2005	At the P2" position, TACE can accommodate basic amino acids, such as arginine and lysine, as well as certain non-basic amino acids such as citrulline, methionine sulfoxide and threonine.	Lysine	82-88	ADAM metallopeptidase domain 17	Homo sapiens	21-25
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-218	S100 calcium binding protein A4	Homo sapiens	0-6
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-218	S100 calcium binding protein A4	Homo sapiens	193-199
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-217	S100 calcium binding protein A4	Homo sapiens	0-6
15788416-5	2005	S100A4 alone or in a complex with annexin II accelerated tissue plasminogen activator-mediated plasminogen activation in solution and on the endothelial cell surface through interaction of the S100A4 C-terminal lysines with the lysine-binding domains of plasminogen.	Lysine	211-217	S100 calcium binding protein A4	Homo sapiens	193-199
15916951-3	2005	Ezh2 methylates histone H3 on lysine 27 (H3K27), which serves as an epigenetic mark mediating silencing.	Lysine	30-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
15829507-2	2005	We show here that BLM is a substrate for small ubiquitin-like modifier (SUMO) modification, with lysines at K317, K331, K334 and K347 being preferred sites of modification.	Lysine	97-104	BLM RecQ like helicase	Homo sapiens	18-21
15829507-3	2005	Unlike normal BLM, a double mutant BLM protein with lysine to arginine substitutions at residues 317 and 331 was not modified by SUMO, and it failed to localize efficiently to the PML nuclear bodies.	Lysine	52-58	BLM RecQ like helicase	Homo sapiens	35-38
15749695-10	2005	Wild type IDE cleaved beta-endorphin at Leu(17)-Phe(18) and Phe(18)-Lys(19), whereas the glutamate mutants cleaved at these sites, but in addition at Lys(19)-Asn(20) and at Met(5)-Thr(6).	Lysine	68-71	insulin degrading enzyme	Homo sapiens	10-13
15882624-4	2005	Revealed function of Ezh2 points to a broader usage of lysine methylation in regulation of both nuclear and extra-nuclear signaling processes.	Lysine	55-61	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	21-25
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Lysine	231-234	coagulation factor X	Homo sapiens	33-36
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Lysine	242-245	coagulation factor X	Homo sapiens	33-36
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Lysine	242-245	coagulation factor X	Homo sapiens	33-36
15831457-3	2005	Lys(35) was found to be a sumoylation site of PIASy.	Lysine	0-3	protein inhibitor of activated STAT 4	Homo sapiens	46-51
15831457-9	2005	These results suggest that sumoylation of Lys(35) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy-dependent sumoylation and transcriptional activation of Tcf-4.	Lysine	42-45	protein inhibitor of activated STAT 4	Homo sapiens	53-58
15831457-9	2005	These results suggest that sumoylation of Lys(35) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy-dependent sumoylation and transcriptional activation of Tcf-4.	Lysine	42-45	protein inhibitor of activated STAT 4	Homo sapiens	98-103
15831457-9	2005	These results suggest that sumoylation of Lys(35) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy-dependent sumoylation and transcriptional activation of Tcf-4.	Lysine	42-45	protein inhibitor of activated STAT 4	Homo sapiens	98-103
15713663-12	2005	Chromatin immunoprecipitation assay demonstrated that cyclin D1 enhanced recruitment of HDAC1 and HDAC3 and histone methyltransferase SUV39H1 to the PPAR response element of the lipoprotein lipase promoter and decreased acetylation of total histone H3 and histone H3 lysine 9.	Lysine	267-273	cyclin D1	Mus musculus	54-63
15835908-2	2005	SU(VAR)3-9 has a SET domain and plays an important role in methylation of lysine-9 of histone H3 which results in gene silencing.	Lysine	74-80	Suppressor of variegation 3-9	Drosophila melanogaster	0-10
15846102-1	2005	We have previously shown that the HDAC inhibitors (HDACI) activate the p53 molecule through acetylation of 320 and 373 lysine residues, upregulate PIG3 and NOXA and induce apoptosis in cancer cells expressing wild and pseudo-wild type p53 genes (Terui T, et al.	Lysine	119-125	histone deacetylase 9	Homo sapiens	34-38
15744310-5	2005	We find that once SIRT1 is induced, it interacts with and deacetylates PGC-1alpha at specific lysine residues in an NAD(+)-dependent manner.	Lysine	94-100	sirtuin 1	Homo sapiens	18-23
15769092-6	2005	The in vitro insulinotropic effect of PEG(2k)-Lys-GLP-1 showed comparable biological activity with native GLP-1 (P = 0.11) in stimulating insulin secretion in isolated rat pancreatic islet and was significantly more potent than the PEG(2k)-N(ter)-GLP-1 (P &lt; 0.05) that showed a marked reduced potency.	Lysine	46-49	glucagon	Rattus norvegicus	50-55
15769092-7	2005	Furthermore, PEG(2k)-Lys-GLP-1 was clearly resistant to purified DPP-IV in buffer with 50-fold increased half-life compared to unmodified GLP-1.	Lysine	21-24	glucagon	Rattus norvegicus	25-30
15769092-7	2005	Furthermore, PEG(2k)-Lys-GLP-1 was clearly resistant to purified DPP-IV in buffer with 50-fold increased half-life compared to unmodified GLP-1.	Lysine	21-24	glucagon	Rattus norvegicus	138-143
15769092-8	2005	When PEG(2k)-Lys-GLP-1 was administered intravenously and subcutaneously into rats, PEGylation improved the half-life, which resulted in substantial improvement of the mean plasma residence time as a 16-fold increase for iv and a 3.2-fold increase for sc.	Lysine	13-16	glucagon	Rattus norvegicus	17-22
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Lysine	218-221	opioid receptor-like 1	Mus musculus	34-62
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Lysine	218-221	prepronociceptin	Mus musculus	98-103
15743813-2	2005	Both repression of AFP during liver development and silencing in the brain, where AFP is never expressed, are associated with dimethylation of histone H3 lysine 9 (DiMetH3K9) and the presence of heterochromatin protein 1 (HP1).	Lysine	154-160	alpha fetoprotein	Mus musculus	19-22
15743813-2	2005	Both repression of AFP during liver development and silencing in the brain, where AFP is never expressed, are associated with dimethylation of histone H3 lysine 9 (DiMetH3K9) and the presence of heterochromatin protein 1 (HP1).	Lysine	154-160	alpha fetoprotein	Mus musculus	82-85
15652519-7	2005	The level of tri-methylation at lysine 27 of histone H3 was substantially decreased in both olezh2 and oleed knock-down embryos, and in embryos with hedgehog signaling perturbed by forskolin.	Lysine	32-38	histone-lysine N-methyltransferase EZH2	Oryzias latipes	92-98
15536085-9	2005	Most interestingly, pH 9-10, which neutralizes the Lys groups of beta-LG, not only reduced its immunoreactivity but also its binding to palmitic acid implicating a role of Lys-69.	Lysine	51-54	beta-lactoglobulin	Bos taurus	65-72
15536085-9	2005	Most interestingly, pH 9-10, which neutralizes the Lys groups of beta-LG, not only reduced its immunoreactivity but also its binding to palmitic acid implicating a role of Lys-69.	Lysine	172-175	beta-lactoglobulin	Bos taurus	65-72
15684403-6	2005	Site-directed mutagenesis identified two lysines (K10 and K197) of BKLF as the sumoylation sites.	Lysine	41-48	Kruppel like factor 3	Homo sapiens	67-71
15654753-6	2005	In addition to two residues, K263 and K343 of p70, previously identified by cocrystallography as direct DNA contacts, we observed protection of five additional lysines (K183, K259, K489, K577, and K588 of p70) upon ssDNA binding to RPA.	Lysine	160-167	annexin A6	Homo sapiens	46-49
15917631-2	2005	Characteristic mass shifts and fragment ions indicating ubiquitinated lysine residues in tryptic and gluC digests are discussed.	Lysine	70-76	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	101-105
15632063-5	2005	In addition, cotransfection data suggest that parafibromin can interact with a histone methyltransferase complex that methylates histone H3 on lysine 4.	Lysine	143-149	cell division cycle 73	Homo sapiens	46-58
15632065-1	2005	Rad6-mediated ubiquitylation of histone H2B at lysine 123 has been linked to transcriptional activation and the regulation of lysine methylation on histone H3.	Lysine	47-53	histone H2B	Saccharomyces cerevisiae S288C	32-43
15632065-1	2005	Rad6-mediated ubiquitylation of histone H2B at lysine 123 has been linked to transcriptional activation and the regulation of lysine methylation on histone H3.	Lysine	126-132	histone H2B	Saccharomyces cerevisiae S288C	32-43
15700778-4	2005	The activities of the membrane-bound and soluble PKC were assessed by 32P enrichment of lysine-rich histone.	Lysine	88-94	protein kinase C, gamma	Rattus norvegicus	49-52
15608118-7	2005	However, small but significant differences are observed; in contrast to the minor groove recognition of TRF1, in which an arginine residue recognizes the TT sequence, a lysine residue of TRF2 interacts with the TT part.	Lysine	169-175	telomeric repeat binding factor 2	Homo sapiens	187-191
15620353-4	2004	LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription.	Lysine	42-48	lysine demethylase 1A	Homo sapiens	0-4
15620353-6	2004	Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant derepression of target genes, suggesting that LSD1 represses transcription via histone demethylation.	Lysine	62-68	lysine demethylase 1A	Homo sapiens	32-36
15620353-6	2004	Importantly, RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant derepression of target genes, suggesting that LSD1 represses transcription via histone demethylation.	Lysine	62-68	lysine demethylase 1A	Homo sapiens	145-149
15491978-2	2004	The human cationic amino acid transporter hCAT-1 is almost ubiquitously expressed and probably the most important entity for supplying cells with extracellular arginine, lysine, and ornithine.	Lysine	170-176	solute carrier family 7 member 1	Homo sapiens	42-48
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	41-44	golgi SNAP receptor complex member 1	Homo sapiens	10-13
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	41-44	golgi SNAP receptor complex member 1	Homo sapiens	163-166
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	255-258	golgi SNAP receptor complex member 1	Homo sapiens	10-13
15496420-6	2004	Moreover, p28 catalyzes the formation of Lys-63-linked polyubiquitin chains in the presence of Ubc13/Uev1A, a heterodimeric E2 conjugating enzyme, indicating that p28 may regulate the biological activity of its cognate viral and/or host cell target(s) by Lys-63-linked ubiquitin multimers.	Lysine	255-258	golgi SNAP receptor complex member 1	Homo sapiens	163-166
15456757-4	2004	The structure displays an overall fold conserved in the proteolytic domain of Ec-Lon; however, the active site shows uniquely configured catalytic Ser-Lys-Asp residues that are not seen in Ec-Lon, which contains a catalytic dyad.	Lysine	151-154	putative ATP-dependent Lon protease	Escherichia coli	81-84
15456757-4	2004	The structure displays an overall fold conserved in the proteolytic domain of Ec-Lon; however, the active site shows uniquely configured catalytic Ser-Lys-Asp residues that are not seen in Ec-Lon, which contains a catalytic dyad.	Lysine	151-154	putative ATP-dependent Lon protease	Escherichia coli	192-195
15456757-6	2004	Consequently, the configurations of the active sites differ due to the formation of a salt bridge between Asp-547 and Lys-593 in Mj-Lon.	Lysine	118-121	putative ATP-dependent Lon protease	Escherichia coli	132-135
15456757-8	2004	The geometry and environment of the active site residues in Mj-Lon suggest that the charged Lys-593 assists in lowering the pK(a) of the Ser-550 hydroxyl group via its electrostatic potential, and the water in the cavity acts as a proton acceptor during catalysis.	Lysine	92-95	putative ATP-dependent Lon protease	Escherichia coli	63-66
15452122-7	2004	Deletion of ASF1 causes a striking loss of acetylation on histone H3 lysine 9, but this is not responsible for the altered chromatin structure in asf1 mutants.	Lysine	69-75	nucleosome assembly factor ASF1	Saccharomyces cerevisiae S288C	12-16
15495159-0	2004	MHC class I-associated presentation of exogenous peptides is not only enhanced but also prolonged by linking with a C-terminal Lys-Asp-Glu-Leu endoplasmic reticulum retrieval signal.	Lysine	127-130	major histocompatibility complex, class I, C	Homo sapiens	0-3
15495159-3	2004	In this study, we observed that exogenous peptides that were artificially fused with an endoplasmic reticulum (ER) retrieval signal, a C-terminal Lys-Asp-Glu-Leu sequence, could be efficiently presented by intracellular MHC class I molecules in a TAP- and proteasome-independent, but brefeldin A-sensitive manner.	Lysine	146-149	major histocompatibility complex, class I, C	Homo sapiens	220-223
15557191-10	2004	These results indicate that the extracellular TLR4 domain-MD-2 complex is capable of binding LPS, and that the extracellular TLR4 domain consisting of Glu(24)-Lys(631) enables MD-2 binding and LPS recognition to TLR4.	Lysine	159-162	lymphocyte antigen 96	Homo sapiens	58-62
15557191-10	2004	These results indicate that the extracellular TLR4 domain-MD-2 complex is capable of binding LPS, and that the extracellular TLR4 domain consisting of Glu(24)-Lys(631) enables MD-2 binding and LPS recognition to TLR4.	Lysine	159-162	lymphocyte antigen 96	Homo sapiens	176-180
15572695-4	2004	Keap1 assembles into a functional E3 ubiquitin ligase complex with Cul3 and Rbx1 that targets multiple lysine residues located in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation both in vivo and in vitro.	Lysine	103-109	ring-box 1	Homo sapiens	76-80
15558052-3	2004	Moreover, it can only bind both AAA and AAG lysine codons when doubly modified with t(6)A37 and either 5-methylaminomethyluridine or 2-thiouridine at the wobble position (mnm(5)U34 or s(2)U34).	Lysine	44-50	N-methylpurine DNA glycosylase	Homo sapiens	40-43
15558052-5	2004	These structures allow the rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG.	Lysine	110-116	N-methylpurine DNA glycosylase	Homo sapiens	132-135
15337742-4	2004	We further revealed that lysine 366 of GATA4 constituted a major sumyolation site.	Lysine	25-31	GATA binding protein 4	Homo sapiens	39-44
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Lysine	146-149	coagulation factor X	Homo sapiens	26-35
15347660-1	2004	The S1 site (Asp(189)) of factor Xa (fXa) is located on a loop (residues 185-189) that contains three solvent-exposed charged residues (Asp(185), Lys(186), and Glu(188)) below the active-site pocket of the protease.	Lysine	146-149	coagulation factor X	Homo sapiens	37-40
15368273-0	2004	Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity.	Lysine	55-61	negative elongation factor complex member C/D	Homo sapiens	172-175
15542783-6	2004	A lead peptide substrate with the sequence Gly-Lys-Ala-Phe-Arg-Arg (GKAFRR) was hydrolyzed by hK2 with a Km of 26.5 micromol/L, kcat of 1.09 s(-1), and a kcat/Km ratio of 41,132 s(-1) mol/L(-1).	Lysine	47-50	RBPJ pseudogene 3	Homo sapiens	94-97
15272000-7	2004	Mutational studies revealed that biotinylation occurs at lysine 86 within the N-terminal domain of Arc1p.	Lysine	57-63	Arc1p	Saccharomyces cerevisiae S288C	99-104
15292251-1	2004	Amino acid substitutions at the Lys-650 codon within the activation loop kinase domain of fibroblast growth factor receptor 3 (FGFR3) result in graded constitutive phosphorylation of the receptor.	Lysine	32-35	fibroblast growth factor receptor 3	Homo sapiens	90-125
15292251-1	2004	Amino acid substitutions at the Lys-650 codon within the activation loop kinase domain of fibroblast growth factor receptor 3 (FGFR3) result in graded constitutive phosphorylation of the receptor.	Lysine	32-35	fibroblast growth factor receptor 3	Homo sapiens	127-132
15231870-10	2004	Our results demonstrate that the binding site residues at position lysine 74 in mGluR4, glutamine 58 in mGluR6, and asparagine 74 in mGluR7 are key determinants of agonist affinity and that additional residues situated outside of the binding pocket, including those present in the extreme amino terminus, also contribute to agonist affinity and the pharmacological profiles of the group III mGluRs.	Lysine	67-73	glutamate receptor, ionotropic, kainate 2 (beta 2)	Mus musculus	104-110
15361936-5	2004	Contrary to the general belief that PGRP-SA has lost enzyme function and serves primarily for PG sensing, we found that it possesses an intrinsic L,D-carboxypeptidase activity for diaminopimelic acid-type tetrapeptide PG fragments but not lysine-type PG fragments, and that Ser158 and His42 may participate in the hydrolytic activity.	Lysine	239-245	Peptidoglycan recognition protein SA	Drosophila melanogaster	36-43
15361936-6	2004	As L,D-configured peptide bonds exist only in prokaryotes, this work reveals a rare enzymatic activity in a eukaryotic protein known for sensing bacteria and provides a possible explanation of how PGRP-SA mediates Toll activation specifically in response to lysine-type PG.	Lysine	258-264	Peptidoglycan recognition protein SA	Drosophila melanogaster	197-204
15220328-3	2004	Here we show that human cancer cells lacking DNMT1 display at least two important differences with respect to wild type cells: a profound disorganization of nuclear architecture, and an altered pattern of histone H3 modification that results in an increase in the acetylation and a decrease in the dimethylation and trimethylation of lysine 9.	Lysine	334-340	DNA methyltransferase 1	Homo sapiens	45-50
15180994-0	2004	Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.	Lysine	13-19	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	103-107
15180994-6	2004	We show here that H3 lysine 4 methylation also negatively regulated gene expression, as strains without Set1 showed enhanced expression of PHO5, wherein chromatin structure plays an important transcriptional regulatory role.	Lysine	21-27	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	139-143
15180994-7	2004	Di- and trimethylation of H3 lysine 4 was detected at the PHO5 promoter, and a strain expressing a mutant version of histone H3 with lysine 4 changed to arginine, (which cannot be methylated) exhibited PHO5 derepression.	Lysine	29-35	acid phosphatase PHO5	Saccharomyces cerevisiae S288C	58-62
15291757-3	2004	Our three-dimensional homology model of 3beta-HSD shows that Tyr154 and Lys158 are oriented near the 3beta-hydroxyl group of the bound substrate steroid, and predicts that Ser123 or Ser124 completes a Tyr-Lys-Ser catalytic triad that operates in many other dehydrogenases.	Lysine	72-75	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	40-49
15273306-7	2004	Within casein kinase 2alpha (CK2alpha), for example, the binding of one of the buried waters appears prohibited by the side chain of a leucine that is highly conserved within CK2alpha and that, along with substitution of lysine for the CMGC-arginine, may contribute to the broad substrate specificity of CK2alpha by relaxing characteristically conserved, precise interactions near the active site.	Lysine	221-227	casein kinase 2 alpha 2	Homo sapiens	7-27
15273306-7	2004	Within casein kinase 2alpha (CK2alpha), for example, the binding of one of the buried waters appears prohibited by the side chain of a leucine that is highly conserved within CK2alpha and that, along with substitution of lysine for the CMGC-arginine, may contribute to the broad substrate specificity of CK2alpha by relaxing characteristically conserved, precise interactions near the active site.	Lysine	221-227	casein kinase 2 alpha 2	Homo sapiens	29-37
15273306-7	2004	Within casein kinase 2alpha (CK2alpha), for example, the binding of one of the buried waters appears prohibited by the side chain of a leucine that is highly conserved within CK2alpha and that, along with substitution of lysine for the CMGC-arginine, may contribute to the broad substrate specificity of CK2alpha by relaxing characteristically conserved, precise interactions near the active site.	Lysine	221-227	casein kinase 2 alpha 2	Homo sapiens	175-183
15273306-7	2004	Within casein kinase 2alpha (CK2alpha), for example, the binding of one of the buried waters appears prohibited by the side chain of a leucine that is highly conserved within CK2alpha and that, along with substitution of lysine for the CMGC-arginine, may contribute to the broad substrate specificity of CK2alpha by relaxing characteristically conserved, precise interactions near the active site.	Lysine	221-227	casein kinase 2 alpha 2	Homo sapiens	175-183
15166213-3	2004	The lysine and leucine biosynthetic pathways each contain a 4Fe-4S cluster enzyme homologous to aconitase and likely to be superoxide-sensitive, homoaconitase (Lys4p) and isopropylmalate dehydratase (Leu1p), respectively.	Lysine	4-10	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	200-205
15236579-1	2004	A number of ligand binding studies of human adult hemoglobin (HbA) cross-linked between Lys 82beta(1) and Lys 82beta(2) with bis(3,5-dibromosalicyl)fumarate have been reported.	Lysine	88-91	keratin 90, pseudogene	Homo sapiens	62-65
15236579-1	2004	A number of ligand binding studies of human adult hemoglobin (HbA) cross-linked between Lys 82beta(1) and Lys 82beta(2) with bis(3,5-dibromosalicyl)fumarate have been reported.	Lysine	106-109	keratin 90, pseudogene	Homo sapiens	62-65
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Lysine	59-62	prepronociceptin	Mus musculus	34-39
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Lysine	75-78	prepronociceptin	Mus musculus	34-39
15186774-6	2004	Our data also indicate that the in vivo binding of the transcription factor Bdf1 is associated with acetylation on most lysines but relative deacetylation on H4 lysine 16.	Lysine	120-127	chromatin-binding protein BDF1	Saccharomyces cerevisiae S288C	76-80
15186774-6	2004	Our data also indicate that the in vivo binding of the transcription factor Bdf1 is associated with acetylation on most lysines but relative deacetylation on H4 lysine 16.	Lysine	120-126	chromatin-binding protein BDF1	Saccharomyces cerevisiae S288C	76-80
15153116-11	2004	These studies suggest that K8 and K12 in histone H4 are targets for biotinylation, that acetylation and biotinylation compete for the same binding sites, and that acetylation and methylation of histones affect biotinylation of neighboring lysines.	Lysine	239-246	H4 clustered histone 9	Homo sapiens	41-51
15140540-4	2004	In the present study, we established a convenient and reliable genotyping method for the MGMT codon 178 polymorphism, a Lys (AAG) to Arg (AGG) substitution, using restriction fragment length polymorphism (RFLP), and studied differences in the distribution of this polymorphism in 92 Caucasian lung cancer patients and 85 controls.	Lysine	120-123	O-6-methylguanine-DNA methyltransferase	Homo sapiens	89-93
15140540-4	2004	In the present study, we established a convenient and reliable genotyping method for the MGMT codon 178 polymorphism, a Lys (AAG) to Arg (AGG) substitution, using restriction fragment length polymorphism (RFLP), and studied differences in the distribution of this polymorphism in 92 Caucasian lung cancer patients and 85 controls.	Lysine	120-123	N-methylpurine DNA glycosylase	Homo sapiens	125-128
15146080-0	2004	Functions for S. cerevisiae Swd2p in 3" end formation of specific mRNAs and snoRNAs and global histone 3 lysine 4 methylation.	Lysine	105-111	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	28-33
15146080-1	2004	The Saccharomyces cerevisiae WD-40 repeat protein Swd2p associates with two functionally distinct multiprotein complexes: the cleavage and polyadenylation factor (CPF) that is involved in pre-mRNA and snoRNA 3" end formation and the SET1 complex (SET1C) that methylates histone 3 lysine 4.	Lysine	280-286	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	50-55
15146080-5	2004	Furthermore, histone 3 lysine 4 di-and tri-methylation were adversely affected and telomeres were shortened in swd2 mutants.	Lysine	23-29	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	111-115
15110758-4	2004	FAST is tethered to mitochondria by a lysine/arginine-rich domain at its carboxyl terminus that is structurally similar to the mitochondrial tethering motifs of monoamine oxidase B and cytochrome b5.	Lysine	38-44	monoamine oxidase B	Homo sapiens	161-180
15116407-10	2004	Pretreating the surface with poly-L-lysine (PG/Lys-GMCSF) prior to adding GM-CSF produced a nearly threefold increase in the surface nitrogen concentration (4.20% compared to 1.47%).	Lysine	29-42	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	51-56
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	168-171	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	138-143
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	168-171	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	144-147
15122025-2	2004	Seed-specific expression of a bacterial feedback-insensitive dihydrodipicolinate synthase (DHPS) in an Arabidopsis knockout mutant of the AtLKR/SDH gene that regulates Lys catabolism synergistically boosted Lys accumulation in mature seeds, but it also severely reduced the growth of seedlings derived from them.	Lysine	207-210	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	138-143
15122025-4	2004	To address these questions, we coexpressed a bacterial DHPS gene with an RNAi construct of AtLKR/SDH, both under control of the same seed-specific promoter, to restrict Lys synthesis and catabolism to the developing seeds.	Lysine	169-172	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	91-96
15122025-4	2004	To address these questions, we coexpressed a bacterial DHPS gene with an RNAi construct of AtLKR/SDH, both under control of the same seed-specific promoter, to restrict Lys synthesis and catabolism to the developing seeds.	Lysine	169-172	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	97-100
15122025-6	2004	However, postgermination seedling growth was significantly improved when the reduction of Lys catabolism was restricted to seed development, suggesting that defective postgermination Lys catabolism was responsible for inhibition of seedling growth in the AtLKR/SDH knockout plants expressing the bacterial DHPS gene in a seed-specific manner.	Lysine	90-93	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	255-260
15122025-6	2004	However, postgermination seedling growth was significantly improved when the reduction of Lys catabolism was restricted to seed development, suggesting that defective postgermination Lys catabolism was responsible for inhibition of seedling growth in the AtLKR/SDH knockout plants expressing the bacterial DHPS gene in a seed-specific manner.	Lysine	183-186	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	255-260
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	87-90	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	53-58
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	87-90	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	59-62
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	53-58
15122025-7	2004	Constitutive expression of the bacterial DHPS in the AtLKR/SDH knockout mutant boosted Lys levels in vegetative tissues in a similar manner to that observed in seeds, further demonstrating that Lys catabolism plays an important regulatory role in balancing Lys levels.	Lysine	194-197	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	59-62
15096047-9	2004	Consistent with this notion, suv3 mutants containing alanine (A) or arginine (R) substitutions at the conserved lysine residue in the ATP binding site (K213) lost ATPase activity and also failed to unwind the substrates.	Lysine	112-118	Suv3 like RNA helicase	Homo sapiens	29-33
14715654-1	2004	Activated thrombin-activable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase B-like plasma enzyme that can slow clot lysis by removing lysine residues exposed on fibrin as it is cleaved by plasmin.	Lysine	140-146	carboxypeptidase B1	Homo sapiens	65-83
15084912-5	2004	Peptide binding studies revealed that the majority of the CII-peptide binding affinity for DR1 and DR4 is controlled by the Phe at 263 and, unexpectedly, the adjacent Lys.	Lysine	167-170	major histocompatibility complex, class II, DR beta 4	Homo sapiens	99-102
15066178-5	2004	Using heparin affinity chromatography, commonly employed in such studies, we define three clusters of arginines and lysines of CCP3, which are important for the interaction of PAPP-A with heparin.	Lysine	116-123	AGBL carboxypeptidase 3	Homo sapiens	127-131
15024081-0	2004	The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.	Lysine	107-113	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	32-36
15024081-1	2004	Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4).	Lysine	197-203	WD-repeat containing protein SWD2	Saccharomyces cerevisiae S288C	0-4
15035645-4	2004	Full-length dSU(VAR)3-9 specifically methylates lysine 9 within histone H3 on peptides, on intact histones, and, to a lesser extent, on nucleosomes.	Lysine	48-54	Suppressor of variegation 3-9	Drosophila melanogaster	12-23
14993789-3	2004	As expected, hC3a containing high levels of Arg- and Lys-residues stimulated approx.	Lysine	53-56	complement C3	Homo sapiens	13-17
15026177-8	2004	The mutants of Tyr(154) and Lys(158) exhibited no dehydrogenase activity and appear to be catalytic 3 beta-HSD residues.	Lysine	28-31	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	100-110
14625280-3	2004	The sequential binding of two cAMPs releases active C. We describe here the properties of RIIbeta and two mutant RIIbeta subunits, engineered by converting a conserved Arg to Lys in each cAMP-binding domain thereby yielding a protein that contains one intact, high affinity cAMP-binding site and one defective site.	Lysine	175-178	protein kinase cAMP-dependent type II regulatory subunit beta	Homo sapiens	113-120
14749728-0	2004	The region 3" to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene.	Lysine	60-63	inactive X specific transcripts	Mus musculus	17-21
14749728-0	2004	The region 3" to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene.	Lysine	60-63	inactive X specific transcripts	Mus musculus	91-95
14749728-6	2004	At the chromatin level, we have found that the Xist gene corresponds to a peak of H3 Lys-4 dimethylation, which is dramatically and specifically affected by the deletion 3" to Xist.	Lysine	85-88	inactive X specific transcripts	Mus musculus	47-51
14749728-6	2004	At the chromatin level, we have found that the Xist gene corresponds to a peak of H3 Lys-4 dimethylation, which is dramatically and specifically affected by the deletion 3" to Xist.	Lysine	85-88	inactive X specific transcripts	Mus musculus	176-180
14749728-7	2004	Our results raise the possibility that H3 Lys-4 dimethylation within Xist may be functionally implicated in the counting process.	Lysine	42-45	inactive X specific transcripts	Mus musculus	69-73
14733935-5	2004	Lysine-less (LL) Id2 is degraded efficiently by the proteasome following ubiquitination.	Lysine	0-6	inhibitor of DNA binding 2	Homo sapiens	17-20
14748079-0	2004	Transglutaminase-mediated modification of glutamine and lysine residues in native bovine beta-lactoglobulin.	Lysine	56-62	beta-lactoglobulin	Bos taurus	89-107
14748079-6	2004	MTGase-mediated BLG crosslinking is hampered by the low reactivity of the lysines and enzymatic deamidation of the glutamines prevails.	Lysine	74-81	beta-lactoglobulin	Bos taurus	16-19
14745807-4	2004	Poly(Lys-25), [(VPGVG)(4)(VPGKG)](39), has a repeat sequence common to natural elastin.	Lysine	5-8	elastin	Homo sapiens	79-86
14695475-6	2004	Here we show that Bcl10 targets NEMO for lysine-63-linked ubiquitination.	Lysine	41-47	B cell leukemia/lymphoma 10	Mus musculus	18-23
14695475-6	2004	Here we show that Bcl10 targets NEMO for lysine-63-linked ubiquitination.	Lysine	41-47	inhibitor of kappaB kinase gamma	Mus musculus	32-36
14734683-5	2004	Compared with our previously reported DOTA-alpha-MSH analog, DOTA-MSH(oct) ([DOTA-betaAla(3),Nle(4),Asp(5),D-Phe(7),Lys(10)]-alpha-MSH(3-10)), the major modification lies in the conjugation of DOTA to the C-terminal end of the peptide via the epsilon-amino group of Lys(11), as opposed to the N-terminal alpha-amino group.	Lysine	116-119	msh homeobox 1	Mus musculus	66-69
14734683-5	2004	Compared with our previously reported DOTA-alpha-MSH analog, DOTA-MSH(oct) ([DOTA-betaAla(3),Nle(4),Asp(5),D-Phe(7),Lys(10)]-alpha-MSH(3-10)), the major modification lies in the conjugation of DOTA to the C-terminal end of the peptide via the epsilon-amino group of Lys(11), as opposed to the N-terminal alpha-amino group.	Lysine	116-119	msh homeobox 1	Mus musculus	66-69
14734683-5	2004	Compared with our previously reported DOTA-alpha-MSH analog, DOTA-MSH(oct) ([DOTA-betaAla(3),Nle(4),Asp(5),D-Phe(7),Lys(10)]-alpha-MSH(3-10)), the major modification lies in the conjugation of DOTA to the C-terminal end of the peptide via the epsilon-amino group of Lys(11), as opposed to the N-terminal alpha-amino group.	Lysine	266-269	msh homeobox 1	Mus musculus	66-69
14734683-5	2004	Compared with our previously reported DOTA-alpha-MSH analog, DOTA-MSH(oct) ([DOTA-betaAla(3),Nle(4),Asp(5),D-Phe(7),Lys(10)]-alpha-MSH(3-10)), the major modification lies in the conjugation of DOTA to the C-terminal end of the peptide via the epsilon-amino group of Lys(11), as opposed to the N-terminal alpha-amino group.	Lysine	266-269	msh homeobox 1	Mus musculus	66-69
14673179-5	2004	IKKbeta-induced degradation is dependent on SCF(beta-TrCP), which acts through multiple lysine residues in the IkappaBgamma domain.	Lysine	88-94	KIT ligand	Homo sapiens	44-47
14687935-2	2004	CPN cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM).	Lysine	43-50	carboxypeptidase N subunit 1	Homo sapiens	0-3
14687935-4	2004	CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine.	Lysine	96-102	carboxypeptidase N subunit 1	Homo sapiens	0-3
14690423-6	2003	TIRFM analysis of solubilized fluorescein 5"-isothiocyanate (FITC)-modified H/K-ATPase at Lys-518 of the alpha-chain showed a quantized photobleaching of the FITC fluorescence intensity.	Lysine	90-93	ATPase H+/K+ transporting subunit alpha	Sus scrofa	76-86
14674748-11	2003	It is suggested that Ser phosphorylation allows protein-protein association by electrostatic stabilization: an obvious negative binding region of Vpu was recognizable by positive residues (Arg and Lys) of the WD domain of beta-TrCP.	Lysine	197-200	Vpu	Human immunodeficiency virus 1	146-149
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	78-84	lysine acetyltransferase 2A	Homo sapiens	19-23
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	150-157	lysine acetyltransferase 2A	Homo sapiens	19-23
14661947-5	2003	A comparison of these structures with tGcn5 bound to histone H3 reveals that the Gcn5/PCAF HATs can accommodate divergent substrates by utilizing analogous interactions with the lysine target and two C-terminal residues with a related chemical nature, suggesting that these interactions play a general role in Gcn5/PCAF substrate binding selectivity.	Lysine	178-184	lysine acetyltransferase 2A	Homo sapiens	81-85
14695212-0	2003	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.	Lysine	69-75	tumor protein p53 inducible protein 3	Homo sapiens	13-17
14701874-3	2003	We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1.	Lysine	110-117	SATB homeobox 1	Homo sapiens	80-85
15019487-3	2003	One of the main experimental strategies used for the study of myotoxic PLA2s is the traditional chemical modification of specific amino acid residues (His, Met, Lys, Tyr, Trp and others) and examination of the consequent effects upon the enzymatic, toxic and pharmacological activities.	Lysine	161-164	phospholipase A2 group IIA	Homo sapiens	71-76
14645664-4	2003	In particular, PKD had lower affinity than PKC for certain diacylglycerol analogs, which might be caused by a lysine residue at the 22 position of the PKD-C1b domain in place of the tryptophan residue at this position conserved in the PKCs.	Lysine	110-116	protein kinase D1	Homo sapiens	15-18
14645664-4	2003	In particular, PKD had lower affinity than PKC for certain diacylglycerol analogs, which might be caused by a lysine residue at the 22 position of the PKD-C1b domain in place of the tryptophan residue at this position conserved in the PKCs.	Lysine	110-116	protein kinase D1	Homo sapiens	151-154
12960171-0	2003	Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.	Lysine	0-7	lymphocyte antigen 96	Homo sapiens	57-61
12972413-3	2003	We found that the PLB monomer with Asn27 or Asn30 changed to Cys (N27C-PLB or N30C-PLB) cross-linked to lysine of SERCA2a within seconds with &gt; or =80% efficiency.	Lysine	104-110	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Canis lupus familiaris	114-121
12960019-3	2003	Systematic alteration of GR DBD amino acids in these chimeras to VDR DBD residues identified arg-49 and lys-53, just C-terminal of the P-box within the base recognition alpha-helix of human VDR (hVDR), as the only two amino acids among 36 differences required to convert the GR core zinc finger domain to that of the VDR.	Lysine	104-107	vitamin D receptor	Homo sapiens	190-193
12960019-3	2003	Systematic alteration of GR DBD amino acids in these chimeras to VDR DBD residues identified arg-49 and lys-53, just C-terminal of the P-box within the base recognition alpha-helix of human VDR (hVDR), as the only two amino acids among 36 differences required to convert the GR core zinc finger domain to that of the VDR.	Lysine	104-107	vitamin D receptor	Homo sapiens	190-193
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Lysine	196-199	vitamin D receptor	Homo sapiens	97-101
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Lysine	271-274	vitamin D receptor	Homo sapiens	97-101
12960019-5	2003	Thus, for RXR heterodimerizing receptors like VDR, the P-box requires redefinition and expansion to include a DNA specificity element corresponding to arg-49 and lys-53 of hVDR.	Lysine	162-165	vitamin D receptor	Homo sapiens	172-176
14585986-4	2003	Of the tested mutations, replacement of six lysine residues with alanine (Gata1KA6), which inhibited self-association activity of Gata1, reduced the Gata1-dependent induction of reporter gene expression driven by the zebra fish gata1 hematopoietic regulatory domain (gata1 HRD).	Lysine	44-50	GATA binding protein 1a	Danio rerio	74-79
14585986-4	2003	Of the tested mutations, replacement of six lysine residues with alanine (Gata1KA6), which inhibited self-association activity of Gata1, reduced the Gata1-dependent induction of reporter gene expression driven by the zebra fish gata1 hematopoietic regulatory domain (gata1 HRD).	Lysine	44-50	GATA binding protein 1a	Danio rerio	130-135
14585986-4	2003	Of the tested mutations, replacement of six lysine residues with alanine (Gata1KA6), which inhibited self-association activity of Gata1, reduced the Gata1-dependent induction of reporter gene expression driven by the zebra fish gata1 hematopoietic regulatory domain (gata1 HRD).	Lysine	44-50	GATA binding protein 1a	Danio rerio	228-233
14585986-4	2003	Of the tested mutations, replacement of six lysine residues with alanine (Gata1KA6), which inhibited self-association activity of Gata1, reduced the Gata1-dependent induction of reporter gene expression driven by the zebra fish gata1 hematopoietic regulatory domain (gata1 HRD).	Lysine	44-50	GATA binding protein 1a	Danio rerio	267-272
14550559-6	2003	Thus poly-L-lysine does not act as substrate, but rather represents an effector molecule, which enhances the chaperone activity of ClpB.	Lysine	5-18	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	131-135
12960054-10	2003	A mutant hFSHR-K555R, which removes the only lysine in the 3i loop available for ubiquitination, was still ubiquitinated, illustrating that, although the third loop enables and interaction with ubiquitin, it is not the sole site of ubiquitination.	Lysine	45-51	follicle stimulating hormone receptor	Homo sapiens	9-14
14550642-1	2003	Lysyl oxidase (LOX) is an extracellular copper dependent enzyme catalyzing lysine-derived cross-links in extracellular matrix proteins.	Lysine	75-81	lysyl oxidase	Homo sapiens	15-18
12926031-1	2003	Studies on the interactions of tissue plasminogen activator (tPA) and plasminogen with polyurethane surfaces containing epsilon-lysine moieties (epsilon-amino group free) are reported.	Lysine	128-134	chromosome 20 open reading frame 181	Homo sapiens	31-59
12926031-1	2003	Studies on the interactions of tissue plasminogen activator (tPA) and plasminogen with polyurethane surfaces containing epsilon-lysine moieties (epsilon-amino group free) are reported.	Lysine	128-134	chromosome 20 open reading frame 181	Homo sapiens	61-64
14523936-6	2003	The analog DOTA-[betaAla(3), Nle(4), Asp(5), D-Phe(7), Lys(10)]-alpha-MSH(3-10) (DOTA-MSH(OCT)), which contains the metal chelator at its N-terminal end, displayed good in vitro MC1R affinity (IC(50) 9.21 nm).	Lysine	55-58	msh homeobox 1	Mus musculus	70-73
12917322-5	2003	We confirm that Set2 catalyzes methylation of lysine 36 on the N-terminal tail of histone H3.	Lysine	46-52	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	16-20
12917322-7	2003	We further show that lysine 36 of histone H3 at GAL4 is methylated and that this methylation is dependent upon the presence of SET2.	Lysine	21-27	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	127-131
14508061-8	2003	Further, direct comparisons of the structures of TGase 3 with other TGases have allowed us to identify several residues that might potentially be involved in generic and specific recognition of the glutamine and lysine substrates.	Lysine	212-218	transglutaminase 3	Homo sapiens	49-56
12932653-6	2003	Microparticles surface-modified for GM-CSF release were prepared from either PG-MP or PG pre-treated with poly-L-lysine (PG-Lys) to manipulate surface charge.	Lysine	106-119	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	36-42
12788924-1	2003	Lysyl oxidase catalyzes oxidative deamination of peptidyl-lysine and hydroxylysine residues in collagens and lysine residues in elastin to form peptidyl aldehydes that are required for the formation of covalent cross-links in normal extracellular matrix biosynthesis.	Lysine	58-64	lysyl oxidase	Homo sapiens	0-13
12764129-5	2003	In addition, we have mapped the major site for SUMO modification on STAT1 to lysine 703.	Lysine	77-83	signal transducer and activator of transcription 1	Homo sapiens	68-73
12764129-6	2003	This lysine residue is in close proximity to the regulatory tyrosine residue at position 701, whose phosphorylation mediates STAT1 activation in response to cytokine signaling.	Lysine	5-11	signal transducer and activator of transcription 1	Homo sapiens	125-130
12878181-1	2003	Lysyl hydroxylases (LH) (procollagen-lysine 2-oxoglutarate 5-dioxygenase; PLOD) catalyse the hydroxylation of lysine residues during the post-translational modification of collagenous proteins.	Lysine	37-43	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Rattus norvegicus	74-78
12746441-5	2003	This sequence element corresponds to Lys-410/413 of Stat1, a reported sequence for Stat1 nuclear translocation.	Lysine	37-40	signal transducer and activator of transcription 1	Homo sapiens	52-57
12746441-5	2003	This sequence element corresponds to Lys-410/413 of Stat1, a reported sequence for Stat1 nuclear translocation.	Lysine	37-40	signal transducer and activator of transcription 1	Homo sapiens	83-88
12845608-1	2003	Several homologues of the Drosophila Su(var)3-9 protein were recently reported to methylate lysine 9 of histone H3.	Lysine	92-98	Suppressor of variegation 3-9	Drosophila melanogaster	37-47
12788062-4	2003	Here, we report that SRF is modified by SUMO-1 chiefly at lysine(147) within the DNA-binding domain.	Lysine	58-64	serum response factor	Homo sapiens	21-24
12783933-9	2003	RESULTS: Activating mutations in NRAS codon 61, all of which were either CAA(Gln)-AAA(Lys) or CAA(Gln)-CGA(Arg) mutations, were found in 95% (20/21) of primary hereditary melanomas but in only 10% (1/10) of sporadic melanomas (P&lt;.001).	Lysine	86-89	NRAS proto-oncogene, GTPase	Homo sapiens	33-37
12820958-3	2003	Of 20 lysines scattered throughout Sic1, 6 N-terminal lysines serve as major ubiquitination sites.	Lysine	6-13	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	35-39
12820958-3	2003	Of 20 lysines scattered throughout Sic1, 6 N-terminal lysines serve as major ubiquitination sites.	Lysine	54-61	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	35-39
12820958-4	2003	Sic1 lacking these lysines (K0N) is stable in vivo, but readdition of any one restores turnover.	Lysine	19-26	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	0-4
12820959-0	2003	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	Lysine	83-89	KIT ligand	Homo sapiens	109-112
12820959-3	2003	The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB, and directs the SCF(beta-TrCP1) to ubiquitinate these proteins at specific lysines.	Lysine	208-215	KIT ligand	Homo sapiens	149-152
12820959-5	2003	The structure, together with the previous SCF(Skp2) structure, leads to the model of SCF catalyzing ubiquitination by increasing the effective concentration of the substrate lysine at the E2 active site.	Lysine	174-180	KIT ligand	Homo sapiens	42-45
12626494-5	2003	Analogues of the alpha4 peptide having increased helicity and still bearing the biologically relevant lysines 156 and 159 on the DNA binding face, and oligonucleotides conserving an intact attachment site, are required to achieve high affinity complexes (Kd of 1.5 nm).	Lysine	102-109	immunoglobulin binding protein 1	Homo sapiens	17-23
12606556-2	2003	Factor Xa attacks two sites in A1, Arg(336), which precedes the highly acidic C-terminal region, and a recently identified site at Lys(36).	Lysine	131-134	coagulation factor X	Homo sapiens	0-9
12755592-12	2003	Although both MCI and MI can react with thiol nucleophiles, only MCI is capable of significantly reacting with amino nucleophiles of the Lys or His type.	Lysine	137-140	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	65-68
12879165-1	2003	We previously showed that lysine substitutions at two residues in segment 6 of domain 3 in voltage-gated Na(+) channel rNav1.4 (S1276K, L1280K) reduced steady-state inactivated local anesthetic block.	Lysine	26-32	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	119-126
12895647-7	2003	In addition, substitution of lysine for arginine residues in the CKS-17 sequence completely abrogates the ability of CKS-17 to phosphorylate PKD/PKCmu.	Lysine	29-35	protein kinase D1	Homo sapiens	141-144
12895647-7	2003	In addition, substitution of lysine for arginine residues in the CKS-17 sequence completely abrogates the ability of CKS-17 to phosphorylate PKD/PKCmu.	Lysine	29-35	protein kinase D1	Homo sapiens	145-150
12556225-8	2003	We accounted for this by proposing that Glu(31), an acidic residue situated at the base of the AB-loop of N-TIMP-3, is drawn into contact with Lys(315), a prominent basic residue adjacent to the TACE catalytic site.	Lysine	143-146	TIMP metallopeptidase inhibitor 3	Homo sapiens	108-114
12556225-8	2003	We accounted for this by proposing that Glu(31), an acidic residue situated at the base of the AB-loop of N-TIMP-3, is drawn into contact with Lys(315), a prominent basic residue adjacent to the TACE catalytic site.	Lysine	143-146	ADAM metallopeptidase domain 17	Homo sapiens	195-199
12556225-10	2003	Further expression of one of the mutants, Lys(26/27/30/76)--&gt;Glu, in a mammalian expression system confirmed that TIMP-3 associates with the extracellular matrix via its C-terminal domain.	Lysine	42-45	TIMP metallopeptidase inhibitor 3	Homo sapiens	117-123
12686141-2	2003	Based on the existent homologies between lysine-rich regions of tropoelastin and the "lysine-rich" histone H1, we tested the possibility that H1 could be a new nuclear target.	Lysine	41-47	elastin	Homo sapiens	64-76
12699818-2	2003	In order to further characterize the human form of this protein, direct electrochemistry of human adrenodoxin (Hadx) has been observed for the first time on a pyrolytic graphite electrode (PGE) modified with poly-L-lysine.	Lysine	208-221	ferredoxin 1	Homo sapiens	98-109
12689588-5	2003	Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure.	Lysine	101-107	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	42-46
12689588-5	2003	Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure.	Lysine	117-123	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	42-46
12670868-3	2003	The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated.	Lysine	43-46	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	9-13
12670868-3	2003	The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated.	Lysine	43-46	histamine N-methyltransferase	Homo sapiens	14-17
12761287-8	2003	When the lysine(15) residue of Smt3 was substituted with arginine, Smt3 chain-polymerization was abolished.	Lysine	9-15	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	31-35
12761287-8	2003	When the lysine(15) residue of Smt3 was substituted with arginine, Smt3 chain-polymerization was abolished.	Lysine	9-15	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	67-71
12611518-1	2003	Photoirradiation at &gt;300 nm of aqueous suspensions of several natural crystal specimens and synthesized crystallites of mercury(II) sulfide (HgS) induced deaminocyclization of optically active or racemic lysine into pipecolinic acid (PCA) under deaerated conditions.	Lysine	207-213	hepatocyte growth factor-regulated tyrosine kinase substrate	Homo sapiens	144-147
12588512-5	2003	The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT(1A)), LY 53857 (5-HT(2A+2C)), ICS 205-930 (5-HT(3+4)) and RS 23597 (5-HT(4)).	Lysine	134-136	oxytocin/neurophysin I prepropeptide	Homo sapiens	44-52
12622383-0	2003	Electrical communication between glucose oxidase and electrodes mediated by phenothiazine-labeled poly(ethylene oxide) bonded to lysine residues on the enzyme surface.	Lysine	129-135	hydroxyacid oxidase 1	Homo sapiens	33-48
12471029-4	2003	Ribonuclease protection assays revealed that one of these splice variants, RyR3 (AS-8a), which lacks a 29-amino acid fragment (His(4406)-Lys(4434)) encompassing a predicted transmembrane helix, was highly expressed in smooth muscle tissues, but not in skeletal muscle, the heart, or the brain.	Lysine	137-140	ryanodine receptor 3	Homo sapiens	75-79
12603087-2	2003	We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG-TCT (Lys-Ser) --&gt; AAG-G-TCT (beta0)] of the beta-globin gene in a thalassemic patient with a mild phenotype.	Lysine	119-122	N-methylpurine DNA glycosylase	Homo sapiens	110-113
12603087-2	2003	We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG-TCT (Lys-Ser) --&gt; AAG-G-TCT (beta0)] of the beta-globin gene in a thalassemic patient with a mild phenotype.	Lysine	119-122	N-methylpurine DNA glycosylase	Homo sapiens	135-138
12566539-2	2003	The Kv2.1 potassium channel contains a lysine in the outer vestibule (position 356) that markedly reduces open channel sensitivity to changes in external [K(+)].	Lysine	39-45	potassium voltage-gated channel subfamily B member 1	Homo sapiens	4-9
12658998-0	2003	[Catalytic dyad Ser-Lys at the active site of Escherichia coli ATP-dependent Lon-proteinase].	Lysine	20-23	putative ATP-dependent Lon protease	Escherichia coli	77-80
12658998-3	2003	The catalytic site of Lon proteases was shown to be represented by the Ser-Lys dyad.	Lysine	75-78	putative ATP-dependent Lon protease	Escherichia coli	22-25
14631847-9	2003	As for CARM1, acetylation of multiple lysines within histone H3 facilitates arginine methylation of by CARM1.	Lysine	38-45	coactivator associated arginine methyltransferase 1	Homo sapiens	7-12
14631847-9	2003	As for CARM1, acetylation of multiple lysines within histone H3 facilitates arginine methylation of by CARM1.	Lysine	38-45	coactivator associated arginine methyltransferase 1	Homo sapiens	103-108
12401797-4	2002	Mutation of all cytoplasmic lysine residues in DOR, creating a mutant opioid receptor that is unable to be ubiquitinated, did not detectably inhibit either ligand-induced endocytosis or proteolytic degradation of endocytosed receptors.	Lysine	28-34	opioid receptor, delta 1	Mus musculus	47-50
12401797-5	2002	Furthermore, the lysine-mutated DOR, like its wild type counterpart, colocalized extensively with lysosomes after ligand-induced endocytosis.	Lysine	17-23	opioid receptor, delta 1	Mus musculus	32-35
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Lysine	165-171	coactivator associated arginine methyltransferase 1	Homo sapiens	31-36
12393906-6	2002	Lysine residues 182 and 185 map within the nuclear localization signal of Mdm2.	Lysine	0-6	MDM2 proto-oncogene	Homo sapiens	74-78
12456661-4	2002	DDM1 and MET1 control heterochromatin assembly at chromocenters by their influence on DNA maintenance (CpG) methylation and subsequent methylation of histone H3 lysine 9.	Lysine	161-167	chromatin remodeling 1	Arabidopsis thaliana	0-4
12456661-4	2002	DDM1 and MET1 control heterochromatin assembly at chromocenters by their influence on DNA maintenance (CpG) methylation and subsequent methylation of histone H3 lysine 9.	Lysine	161-167	methyltransferase 1	Arabidopsis thaliana	9-13
12456661-5	2002	In addition, DDM1 is required for deacetylation of histone H4 lysine 16.	Lysine	62-68	chromatin remodeling 1	Arabidopsis thaliana	13-17
12427028-5	2002	Mutation of the Arg to either Ala or Lys abolished Hid and Smac binding to BIRs, despite the Hid/Smac binding site being located on the opposite side of the BIR domain from the Arg.	Lysine	37-40	diablo	Drosophila melanogaster	59-63
12423343-5	2002	Furthermore, we explored the oxidative deamination via the Maillard reaction and demonstrated that the lysine residue of bovine serum albumin is oxidatively deaminated during the incubation with various carbohydrates in the presence of Cu2+ at a physiological pH and temperature.	Lysine	103-109	albumin	Rattus norvegicus	128-141
12196519-1	2002	The cationic amino acid transporter, Cat-1, is a high affinity transporter of the essential amino acids, arginine and lysine.	Lysine	118-124	solute carrier family 7 member 1	Homo sapiens	37-42
12374740-3	2002	Here, we discover a pocket in the kinase domain of PDK1 that recognizes the phosphoserine/phosphothreonine in the hydrophobic motif by identifying two oppositely positioned arginine and lysine residues that bind the phosphate.	Lysine	186-192	pyruvate dehydrogenase kinase 1	Homo sapiens	51-55
12364545-5	2002	The substitution of this evolutionary conserved glutamate residue for lysine in the mouse ABCA1 transporter leads to complete loss of function, resulting principally from defective intracellular trafficking and very little ABCA1 reaching the plasma membrane.	Lysine	70-76	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	90-95
12364545-5	2002	The substitution of this evolutionary conserved glutamate residue for lysine in the mouse ABCA1 transporter leads to complete loss of function, resulting principally from defective intracellular trafficking and very little ABCA1 reaching the plasma membrane.	Lysine	70-76	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	223-228
12353039-4	2002	Both pathways require the ESA1 histone acetyl transferase (HAT), which is responsible for acetylating all H4 tail lysines, including ectopic lysines that restore repair capacity to a mutant H4 tail.	Lysine	114-121	lysine acetyltransferase 5	Homo sapiens	26-30
12353039-4	2002	Both pathways require the ESA1 histone acetyl transferase (HAT), which is responsible for acetylating all H4 tail lysines, including ectopic lysines that restore repair capacity to a mutant H4 tail.	Lysine	141-148	lysine acetyltransferase 5	Homo sapiens	26-30
12082110-2	2002	VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN.	Lysine	97-100	vitronectin	Homo sapiens	0-2
12197713-4	2002	This analysis provided, for the first time, the hydrogen exchange rate constants for Lys and Arg side chains in a protein and pointed to an internal catalysis of the N-terminal amino protons in BPTI by a salt bridge.	Lysine	85-88	spleen trypsin inhibitor I	Bos taurus	194-198
12202949-0	2002	Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.	Lysine	0-6	solute carrier family 7 member 1	Homo sapiens	49-55
12200128-7	2002	Mutation of lysine 1086 of SALL1 to arginine abrogates SALL1 sumoylation, suggesting the presence of a polymeric SUMO-1 chain in the wild type state.	Lysine	12-18	spalt like transcription factor 1	Homo sapiens	27-32
12200128-7	2002	Mutation of lysine 1086 of SALL1 to arginine abrogates SALL1 sumoylation, suggesting the presence of a polymeric SUMO-1 chain in the wild type state.	Lysine	12-18	spalt like transcription factor 1	Homo sapiens	55-60
12039950-3	2002	As one example, histone H3 phosphorylation at serine 10 (Ser(10)) facilitates acetylation of lysine 14 (Lys(14)) by Gcn5 in vitro (, ).	Lysine	93-99	lysine acetyltransferase 2A	Homo sapiens	116-120
12039950-3	2002	As one example, histone H3 phosphorylation at serine 10 (Ser(10)) facilitates acetylation of lysine 14 (Lys(14)) by Gcn5 in vitro (, ).	Lysine	104-107	lysine acetyltransferase 2A	Homo sapiens	116-120
12048190-5	2002	This interaction was very stable and was dependent on lysines 410 and 413 of STAT1.	Lysine	54-61	signal transducer and activator of transcription 1	Homo sapiens	77-82
12217642-7	2002	Lysine-rich neurofilament protein subunits NF-H and NF-M are more susceptible than lysine-poor NF-L and beta-tubulin to 1,2-DAB.	Lysine	0-6	neurofilament medium chain	Homo sapiens	52-56
12217642-7	2002	Lysine-rich neurofilament protein subunits NF-H and NF-M are more susceptible than lysine-poor NF-L and beta-tubulin to 1,2-DAB.	Lysine	83-89	neurofilament light chain	Homo sapiens	95-99
12062854-2	2002	For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid--&gt;glutamic acid) and 420 (threonine--&gt;lysine) may affect genetic susceptibility to T2DM.	Lysine	172-178	GC vitamin D binding protein	Homo sapiens	47-72
12202230-6	2002	Moreover, replacement of lysine by arginine in the basic domains decreases the trans-activating capacity of CREB-2.	Lysine	25-31	activating transcription factor 4	Homo sapiens	108-114
11994311-2	2002	GCN5 is the catalytic subunit of a large multi-subunit complex that functions in the regulation of gene activation via acetylation of lysine residues within the N-terminal tails of core histone proteins.	Lysine	134-140	lysine acetyltransferase 2A	Homo sapiens	0-4
12130538-0	2002	G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.	Lysine	78-84	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-29
12109867-1	2002	BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) associated with a deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene suffer sudden cardiac death at all ages.	Lysine	90-96	troponin I3, cardiac type	Homo sapiens	118-136
12109867-1	2002	BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) associated with a deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene suffer sudden cardiac death at all ages.	Lysine	90-96	troponin I3, cardiac type	Homo sapiens	138-142
12080090-6	2002	This defect in telomeric silencing might reflect an interaction between Sir proteins and Lys 79, because dot1 and Lys 79 mutations weaken the interaction of Sir2 and Sir3 with the telomeric region in vivo.	Lysine	89-92	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	166-170
12080090-6	2002	This defect in telomeric silencing might reflect an interaction between Sir proteins and Lys 79, because dot1 and Lys 79 mutations weaken the interaction of Sir2 and Sir3 with the telomeric region in vivo.	Lysine	114-117	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	166-170
12119107-1	2002	Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates.	Lysine	93-96	arginyl aminopeptidase	Homo sapiens	0-16
12119107-1	2002	Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates.	Lysine	93-96	arginyl aminopeptidase	Homo sapiens	18-21
12044908-6	2002	Alanine substitution of a lysine residue placed centrally in beta-strand 5A implied a VN-induced acceleration of latency transition, instead of the normal delay.	Lysine	26-32	vitronectin	Homo sapiens	86-88
11861643-3	2002	We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296, Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity.	Lysine	114-117	monoamine oxidase B	Homo sapiens	202-207
12010780-4	2002	Here we describe the in vitro and in vivo pharmacological profile of a novel NOP receptor ligand, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101).	Lysine	115-118	prepronociceptin	Mus musculus	123-128
11994533-2	2002	METHODS: Annexin V was iodinated with (125)I using 2 different techniques: direct iodination with IODO-BEADS, resulting in the iodination of tyrosine residues; and use of the Bolton-Hunter reagent, which binds to lysine.	Lysine	213-219	annexin A5	Mus musculus	9-18
11939781-0	2002	Contribution of buried lysine residues to the oligomerization specificity and stability of the fos coiled coil.	Lysine	23-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-98
11939781-4	2002	The Fos coiled coil contains two polar position a Lys residues (Lys 16 and Lys 30 of Fos-p1, a peptide corresponding to the coiled-coil domain of v-Fos).	Lysine	50-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
11781318-1	2002	The cationic amino acid transporter, Cat-1, is a high affinity transporter of the essential amino acids, arginine and lysine.	Lysine	118-124	solute carrier family 7 member 1	Homo sapiens	37-42
11835157-6	2002	We used the Hoffman degradation reaction to convert the amide groups of acrylamide to amine groups, and then we used ethylene glycol diglycidyl ether to attach biomolecules of interest inside the holes: secreted protein acidic and rich in cysteine (SPARC) peptide Lys-Gly-His-Lys (KGHK; angiogenic), thrombospondin-2 (TSP; antiangiogenic), or albumin (rat; neutral).	Lysine	264-267	secreted protein acidic and cysteine rich	Rattus norvegicus	203-247
11835157-6	2002	We used the Hoffman degradation reaction to convert the amide groups of acrylamide to amine groups, and then we used ethylene glycol diglycidyl ether to attach biomolecules of interest inside the holes: secreted protein acidic and rich in cysteine (SPARC) peptide Lys-Gly-His-Lys (KGHK; angiogenic), thrombospondin-2 (TSP; antiangiogenic), or albumin (rat; neutral).	Lysine	276-279	secreted protein acidic and cysteine rich	Rattus norvegicus	203-247
11923469-0	2002	Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.	Lysine	0-6	thyroid stimulating hormone receptor	Homo sapiens	40-52
11790772-2	2002	Computer modeling of human IL-18 identified two charged residues, Glu-42 and Lys-89, which interact with oppositely charged amino acid residues buried in a large hydrophobic pocket of IL-18BP.	Lysine	77-80	interleukin 18	Homo sapiens	27-32
11790772-10	2002	The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP.	Lysine	42-45	interleukin 18	Homo sapiens	103-108
11937099-2	2002	Here, we demonstrate that repeated administration of the novel neurotensin-(8-13) analogue NT69L [(N-methyl-Arg), Lys, Pro, L-neo-Trp, tert-Leu, Leu] induce tolerance to its suppressant effect on conditioned avoidance behaviour in rats, a predictive assay for antipsychotic activity.	Lysine	114-117	neurotensin	Rattus norvegicus	63-74
12051975-3	2002	We have tentatively chosen seven transmembrane helices, TM1, TM2, TM4, TM8, TM10, TM12 and TM13 to form a conical channel using the well-established Glu 681 of TM8 and candidates Lys 826 and Arg 730 of TM12-13 and TM10, respectively, to form the inverting basket.	Lysine	179-182	tetraspanin 16	Homo sapiens	71-74
12051975-3	2002	We have tentatively chosen seven transmembrane helices, TM1, TM2, TM4, TM8, TM10, TM12 and TM13 to form a conical channel using the well-established Glu 681 of TM8 and candidates Lys 826 and Arg 730 of TM12-13 and TM10, respectively, to form the inverting basket.	Lysine	179-182	tetraspanin 16	Homo sapiens	160-163
11859155-0	2002	Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.	Lysine	41-47	Heterochromatin Protein 1c	Drosophila melanogaster	13-16
11859155-1	2002	The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines.	Lysine	101-108	Heterochromatin Protein 1c	Drosophila melanogaster	24-27
11884629-0	2002	Involvement of conserved histidine, lysine and tyrosine residues in the mechanism of DNA cleavage by the caspase-3 activated DNase CAD.	Lysine	36-42	caspase 3	Mus musculus	105-114
11839797-4	2002	Here, we describe the biochemical purification and characterization of Set2, a novel HMT that is site-specific for lysine 36 (Lys36) of the H3 tail.	Lysine	115-121	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	71-75
11911775-6	2002	We have shown that small, recombinantly expressed polypeptides based on sequences of human elastin contain sufficient information to self-organize into fibrillar structures and promote the formation of lysine-derived cross-links.	Lysine	202-208	elastin	Homo sapiens	91-98
11864927-9	2002	Tolerance to H2O2 is encoded by a unique stretch of lysines at the COOH terminus of the Ki-Ras, lacking in Ha-Ras, and it is relatively independent of the farnesylated anchor.	Lysine	52-59	KRAS proto-oncogene, GTPase	Homo sapiens	88-94
11814357-9	2002	Moreover, they emphasize the importance of the S-28(1-12) segment joining Arg(-15) and Arg(-2)Lys(-1) cleavage sites whose conformational organization is essential for controlling their accessibility to the appropriate processing proteases.	Lysine	94-97	somatostatin	Homo sapiens	47-51
11850543-5	2002	All MRT samples had missense mutations in the human KRT 8 gene, i.e., Arg89 --&gt; Cys (5/7); Arg --&gt; Cys251 (3/7); Glu267 --&gt; Lys (6/7); Ser290 --&gt; Ile, Met; (7/7) and Arg301 --&gt; His(4/7), none of which was detected in any control samples.	Lysine	133-136	keratin 8	Homo sapiens	52-57
11777974-8	2002	The three Ly-49C mutations that affected MHC binding correspond to Ly-49A residues that are in contact or close to H-2D(d) in the co-crystal, demonstrating that MHC class I binding by Ly-49C is dependent on residues in the same area as that used by Ly-49A for ligand contacts.	Lysine	10-12	major histocompatibility complex, class I, C	Homo sapiens	41-44
11777974-8	2002	The three Ly-49C mutations that affected MHC binding correspond to Ly-49A residues that are in contact or close to H-2D(d) in the co-crystal, demonstrating that MHC class I binding by Ly-49C is dependent on residues in the same area as that used by Ly-49A for ligand contacts.	Lysine	10-12	major histocompatibility complex, class I, C	Homo sapiens	161-164
11777974-8	2002	The three Ly-49C mutations that affected MHC binding correspond to Ly-49A residues that are in contact or close to H-2D(d) in the co-crystal, demonstrating that MHC class I binding by Ly-49C is dependent on residues in the same area as that used by Ly-49A for ligand contacts.	Lysine	67-69	major histocompatibility complex, class I, C	Homo sapiens	41-44
11777974-8	2002	The three Ly-49C mutations that affected MHC binding correspond to Ly-49A residues that are in contact or close to H-2D(d) in the co-crystal, demonstrating that MHC class I binding by Ly-49C is dependent on residues in the same area as that used by Ly-49A for ligand contacts.	Lysine	67-69	major histocompatibility complex, class I, C	Homo sapiens	161-164
11739114-9	2002	We conclude that 1) in the mouse proximal tubule, P-gp-induced modulation of RVI occurs via PKC; and 2) the microtubule, microfilament, and wortmannin-sensitive, LY-294002-insensitive PI 3-kinase contribute to the PKC-induced RVI.	Lysine	162-164	phosphoglycolate phosphatase	Mus musculus	50-54
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Lysine	116-122	carboxypeptidase N subunit 1	Homo sapiens	0-18
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Lysine	116-122	carboxypeptidase N subunit 1	Homo sapiens	20-23
11749542-5	2001	We thus conclude that the preferred mechanism may well be different from that in solution, involving an equilibrium pre-protonation of OMP C5 by a catalytic lysine residue that greatly reduces the barrier to subsequent decarboxylation.	Lysine	157-163	olfactory marker protein	Homo sapiens	135-138
11679292-3	2001	The presence of poly-L-lysine and glutaraldehyde during electropolymerization of poly(1,3-DAB) improves sensitivity by raising the amount of GOx immobilized.	Lysine	16-29	hydroxyacid oxidase 1	Homo sapiens	141-144
11767101-5	2001	The active site Lys residue in BPTI is replaced by an Arg residue in SETI.	Lysine	16-19	spleen trypsin inhibitor I	Bos taurus	31-35
11733024-4	2001	We report here that amino-acid substitutions in a buried cluster of three residues forming a hydrogen bonding network in the shutter region drastically accelerate PAI-1 latency transition; that the rate was in all cases normalized by the PAI-1 binding protein vitronectin; and that substitution of an adjacent beta strand 5A Lys residue, believed to anchor beta strand 5A to other secondary structural elements, had differential effects on the rates of latency transition in the absence and the presence of vitronectin, respectively.	Lysine	325-328	vitronectin	Homo sapiens	260-271
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	46-52	MDM2 proto-oncogene	Homo sapiens	86-90
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Lysine	256-263	MDM2 proto-oncogene	Homo sapiens	86-90
11716687-8	2001	The primary site of DTPA modification on N-TIMP-2 was mapped to lysine-116, which is distant from the site of MMP interaction.	Lysine	64-70	TIMP metallopeptidase inhibitor 2	Homo sapiens	41-49
11602718-6	2001	Chimeric Envs between HIV-2/vcp and a CD4-dependent clone of HIV-2/NIHz as well as site-directed Env mutations implicated a positively charged amino acid (lysine or arginine) at position 427 in the C4 region of the HIV-2/vcp env gene product (VCP) gp120 as a key determinant for this phenotype.	Lysine	155-161	endogenous retrovirus group K member 20	Homo sapiens	225-228
11593024-5	2001	Other lysines in the N-terminal tail of histone H4 showed intermediate and variable levels of enrichment.	Lysine	6-13	H4 clustered histone 9	Homo sapiens	40-50
11557524-5	2001	Substitution of Leu at position 1084 of rat MRP3 (which corresponds to Arg-1096 in rat MRP2) with Lys, but not with Val or Met, resulted in the loss of transport activity for TC and glucuronide conjugates.	Lysine	98-101	ATP binding cassette subfamily C member 2	Rattus norvegicus	87-91
11544208-2	2001	Threonine-199 is the site of autophosphorylation of DnaK, and the lysine residue of bovine Hsc70 corresponding to K70 of DnaK has been shown to be essential for the hydrolysis of ATP.	Lysine	66-72	heat shock protein family A (Hsp70) member 8	Bos taurus	91-96
11587849-2	2001	Similar to the ubiquitin system, SUMO1/Smt3 is activated in an ATP-dependent reaction by thioester bond formation with E1 (activating enzyme), transferred to E2 (conjugating enzyme), and passed to a substrate lysine.	Lysine	209-215	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	39-43
11557039-5	2001	The use of CK2 alpha mutants made it possible to map the Grp94-CT binding site to the four lysine stretch (residues 74-77) present in helix C of CK2 alpha.	Lysine	91-97	casein kinase 2 alpha 2	Homo sapiens	11-20
11557039-5	2001	The use of CK2 alpha mutants made it possible to map the Grp94-CT binding site to the four lysine stretch (residues 74-77) present in helix C of CK2 alpha.	Lysine	91-97	heat shock protein 90 beta family member 1	Homo sapiens	57-62
11557039-5	2001	The use of CK2 alpha mutants made it possible to map the Grp94-CT binding site to the four lysine stretch (residues 74-77) present in helix C of CK2 alpha.	Lysine	91-97	casein kinase 2 alpha 2	Homo sapiens	145-154
11500552-0	2001	A T-DNA insertion knockout of the bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase gene elevates lysine levels in Arabidopsis seeds.	Lysine	47-53	Saccharopine dehydrogenase	Arabidopsis thaliana	78-104
11500552-5	2001	The phenotype of the LKR/SDH knockout was indistinguishable from wild-type plants under normal growth conditions, suggesting that Lys catabolism is not an essential pathway under standard growth conditions.	Lysine	130-133	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	21-28
11444968-7	2001	Weak inhibition of a human mutant PBGS establishes that the inactivation by 4,7-DOSA requires formation of a Schiff base to a lysine that normally forms a Schiff base intermediate to one substrate molecule.	Lysine	126-132	aminolevulinate dehydratase	Homo sapiens	34-38
11444968-8	2001	A 1.9 A resolution crystal structure of E. coli PBGS complexed with 4,7-DOSA (PDB code ) shows one dimer per asymmetric unit and reveals that the inhibitor forms two Schiff base linkages with each monomer, one to the normal Schiff base-forming Lys-246 and the other to a universally conserved "perturbing" Lys-194 (E. coli numbering).	Lysine	244-247	aminolevulinate dehydratase	Homo sapiens	48-52
11444968-8	2001	A 1.9 A resolution crystal structure of E. coli PBGS complexed with 4,7-DOSA (PDB code ) shows one dimer per asymmetric unit and reveals that the inhibitor forms two Schiff base linkages with each monomer, one to the normal Schiff base-forming Lys-246 and the other to a universally conserved "perturbing" Lys-194 (E. coli numbering).	Lysine	306-309	aminolevulinate dehydratase	Homo sapiens	48-52
11445074-7	2001	However, Pro or Lys in the P1 position and Pro in the P1" positions are incompatible with TPP-I activity.	Lysine	16-19	tripeptidyl peptidase 1	Homo sapiens	90-95
11413387-6	2001	The PB1 epitope is only the fourth D(k)-presented peptide to be reported and the sequence of this epitope confirms a D(k)-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.	Lysine	200-206	polybromo 1	Homo sapiens	4-7
11278650-6	2001	Two residues were identified in the FKN-CD, namely Lys-7 and Arg-47, that are important determinants in mediating an FKN-CX3CR1 interaction.	Lysine	51-54	C-X3-C motif chemokine receptor 1	Homo sapiens	121-127
11297527-7	2001	Site-directed mutagenesis suggested an important role for lysine 131 of CLP in mediating 5LO binding.	Lysine	58-64	coactosin like F-actin binding protein 1	Homo sapiens	72-75
11343802-9	2001	The presence of a serine or threonine adjacent to the active site lysine in protein kinases is rare and, in MEKK3, results in detergent instability.	Lysine	66-72	mitogen-activated protein kinase kinase kinase 3	Homo sapiens	108-113
11424233-4	2001	RESULTS: There are two alleles in the Kir6.2 gene: EI, glutamic acid at codon 23 and isoleucine at codon 337 and KV, lysine at codon 23 and valine at codon 337.	Lysine	117-123	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	38-44
11336674-5	2001	Based on the available structural and biochemical evidence, we present a unified scenario for the GEF mechanism where interaction of the P loop lysine with an acidic residue is a crucial element for the overall reaction.	Lysine	144-150	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	98-101
11369207-12	2001	Glutamic acid substitution of the four lysine residues in the polybasic stretch at the COOH terminus of Ki-Ras completely abolishes the activation of Mn-SOD, although it does not inhibit ERK1/2-induced transcription.	Lysine	39-45	KRAS proto-oncogene, GTPase	Homo sapiens	104-110
11286508-1	2001	In mammals, L-lysine is first catabolized to alpha-aminoadipate semialdehyde by the bifunctional enzyme alpha-aminoadipate semialdehyde synthase (AASS), followed by a conversion to alpha-aminoadipate by alpha-aminoadipate semialdehyde dehydrogenase.	Lysine	12-20	aminoadipate-semialdehyde synthase	Homo sapiens	104-144
11250042-12	2001	The 469 E/K polymorphism is in exon 6 and results in a change from glutamic acid to lysine in Ig-like domain 5 of ICAM-1, which is thought to affect interactions with LFA-1 and adhesion of B-cells.	Lysine	84-90	intercellular adhesion molecule 1	Homo sapiens	114-120
11245429-7	2001	By analyzing the acetylation of specific lysine residues at the amino terminus of histone H4 (Ac-5, Ac-8, Ac-12, and Ac-16), we found that the enhancement of HDAC inhibitor-induced acetylation of histones in the DAC-pretreated cells was not lysine site specific.	Lysine	41-47	adenylate cyclase 8	Homo sapiens	100-104
11161971-8	2001	The third mutation is a missense error present in the eighth exon of the C1INH; at nucleotide 16867 (amino acid 470), a T to A mutation transforms a Met to a Lys.	Lysine	158-161	serpin family G member 1	Homo sapiens	73-78
11168397-6	2001	Changing the His6 residue of alpha-MSH-ND to Gln or Lys markedly decreased CRE-mediated luciferase activity for MC3R compared with MC4R.	Lysine	52-55	melanocortin 4 receptor	Homo sapiens	131-135
11016932-10	2001	These results indicate that the basic residues, particularly Lys(312)-Lys(313), in the region between the H helix and C2 sheet of kallistatin, comprise a major heparin-binding site responsible for its heparin-suppressed tissue kallikrein binding.	Lysine	61-64	serpin family A member 4	Homo sapiens	130-141
11016932-10	2001	These results indicate that the basic residues, particularly Lys(312)-Lys(313), in the region between the H helix and C2 sheet of kallistatin, comprise a major heparin-binding site responsible for its heparin-suppressed tissue kallikrein binding.	Lysine	70-73	serpin family A member 4	Homo sapiens	130-141
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	144-150	aminolevulinate dehydratase	Homo sapiens	43-47
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	144-150	aminolevulinate dehydratase	Homo sapiens	178-182
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	186-189	aminolevulinate dehydratase	Homo sapiens	43-47
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	186-189	aminolevulinate dehydratase	Homo sapiens	178-182
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	215-218	aminolevulinate dehydratase	Homo sapiens	43-47
11032841-2	2001	The only characterized intermediate in the PBGS-catalyzed reaction is a Schiff base that forms between the first ALA that binds and a conserved lysine, which in Escherichia coli PBGS is Lys-246 and in human PBGS is Lys-252.	Lysine	215-218	aminolevulinate dehydratase	Homo sapiens	178-182
11027681-1	2001	The plasminogen receptors responsible for enhancing cell surface-dependent plasminogen activation expose COOH-terminal lysines on the cell surface and are sensitive to proteolysis by carboxypeptidase B (CpB).	Lysine	119-126	carboxypeptidase B1	Homo sapiens	183-201
11027681-1	2001	The plasminogen receptors responsible for enhancing cell surface-dependent plasminogen activation expose COOH-terminal lysines on the cell surface and are sensitive to proteolysis by carboxypeptidase B (CpB).	Lysine	119-126	carboxypeptidase B1	Homo sapiens	203-206
11027681-5	2001	The cDNA for the 54-kDa protein matched the human TIP49a sequence, and encoded a COOH-terminal lysine, consistent with susceptibility to CpB.	Lysine	95-101	carboxypeptidase B1	Homo sapiens	137-140
11112693-5	2001	A bipartite basic nuclear localization signal between amino acids 539-556 of Ku70 was observed to be required for nuclear import of full-length Ku70 monomer, while a short Ku80 motif of four amino acids from 565-568 containing three lysines was required for the nuclear import of full-length Ku80.	Lysine	233-240	X-ray repair cross complementing 6	Homo sapiens	77-81
11642359-2	2001	LOX has been traditionally known for one function, the extracellular catalysis of lysine-derived cross-links in fibrillar collagens and elastin.	Lysine	82-88	lysyl oxidase	Homo sapiens	0-3
11114158-8	2000	Supporting a functional role for Lys-239 in CtBP binding, mutation of this residue to Ala decreases the ability of E1A to block cAMP-regulated enhancer (CRE)-binding protein (CREB)-stimulated gene expression.	Lysine	33-36	cAMP responsive element binding protein 1	Homo sapiens	175-179
11118214-4	2000	P/CAF-mediated acetylation, which mapped to a lysine-rich motif in the loop region, increased TAL1 binding to DNA while selectively inhibiting its interaction with the transcriptional co-repressor mSin3A.	Lysine	46-52	transcriptional regulator, SIN3A (yeast)	Mus musculus	197-203
11090279-6	2000	The GCN5 bromodomain binds the small ligands N(omega)-acetylhistamine and N-methylacetamide, confirming specificity for the alkyl acetamide moiety and showing that the primary element of recognition is simply the sterically unhindered terminal acetamide moiety of an acetylated lysine residue.	Lysine	278-284	lysine acetyltransferase 2A	Homo sapiens	4-8
11094089-3	2000	Although the A4 mutant protein and the single lysine substitutions both bound MDM2 reasonably well, the single lysine substitutions underwent normal MDM2-dependent ubiquitination, whereas the A4 protein was inefficiently ubiquitinated.	Lysine	46-52	MDM2 proto-oncogene	Homo sapiens	78-82
11101902-6	2000	Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule"s surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.	Lysine	152-155	dishevelled segment polarity protein 1	Mus musculus	82-85
11063570-7	2000	Mutation of pairs of these histidines (and one lysine) in CAII to the analogous residues in CAI (H3P/H4D or K9D/H10K or H15Q/H17S), or combinations of these various double mutants, did not greatly affect binding between GST-Ct and the mutant CAII.	Lysine	47-53	carbonic anhydrase 2	Homo sapiens	58-62
11053128-8	2000	Mutation of two lysine residues in the outer vestibule of Kv2.1 (K356 and K382), to smaller, uncharged residues (glycine and valine, respectively), completely abolished K(+)-dependent potentiation that was not associated with inactivation.	Lysine	16-22	potassium voltage-gated channel subfamily B member 1	Homo sapiens	58-63
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Lysine	25-31	MDM2 proto-oncogene	Homo sapiens	195-199
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Lysine	25-31	MDM2 proto-oncogene	Homo sapiens	241-245
11080311-0	2000	Characterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite AtLKR/SDH locus of Arabidopsis.	Lysine	67-73	Saccharopine dehydrogenase	Arabidopsis thaliana	28-54
11080311-0	2000	Characterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite AtLKR/SDH locus of Arabidopsis.	Lysine	67-73	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	123-126
11080311-7	2000	Excess levels of this enzyme might enable efficient flux of lysine catabolism via the SDH reaction in the unfavorable physiological pH of the cytosol.	Lysine	60-66	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	86-89
11369259-3	2000	Moreover, certain basic residues of this site, particularly Arg(165) and Lys(169), play a key role in factor Va and/or prothrombin recognition by factor Xa in the prothrombinase complex.	Lysine	73-76	coagulation factor X	Homo sapiens	146-155
11083062-7	2000	Structure analysis of drosomycin and Rs-AFP2, and comparisons with the other modeled antifungal structures, revealed that the two proteins shared a hydrophobic cluster located at the protein surface in which a lysine residue is embedded.	Lysine	210-216	Drosomycin	Drosophila melanogaster	22-32
10974350-6	2000	Using carboxypeptidase B digestion, the plasminogen-binding site of antithrombin III was localized to the carboxy-terminus lysine of the anticoagulant protein.	Lysine	123-129	carboxypeptidase B1	Homo sapiens	6-24
10851234-7	2000	By combining these methods, we showed that Nsp3 is phosphorylated on serine residues 320, 327, 332, 335, 356, 359, 362, and 367, and is heavily phosphorylated on peptide Gly(338)-Lys(415), which carries 7-12 phosphates distributed over its 13 potential phosphorylation sites.	Lysine	179-182	SH2 domain containing 3C	Homo sapiens	43-47
10999748-6	2000	The incidence of the positive expression of MMP-9 in n(+)-IMGCs (67%) or ly(+)-IMGCs (86%) was significantly higher than that in n(-)-IMGCs (32%) or ly(-)-IMGCs (34%).	Lysine	73-79	matrix metallopeptidase 9	Homo sapiens	44-49
10816585-2	2000	Comparisons were made with alpha(2)-antiplasmin (alpha(2)-AP), which is known to cross-link to lysine 303 of the Aalpha chain.	Lysine	95-101	serpin family F member 2	Homo sapiens	49-60
10816585-3	2000	A 30-residue peptide containing Lys-303 specifically competed with fibrinogen for cross-linking to alpha(2)-AP but not for cross-linking to PAI-2.	Lysine	32-35	serpin family F member 2	Homo sapiens	99-110
10816585-7	2000	alpha(2)-AP was cross-linked only to lysine 303.	Lysine	37-43	serpin family F member 2	Homo sapiens	0-11
10899625-6	2000	Past studies predicted that AT II production versus destruction discriminates alpha- from beta-chymases and that Lys(40) in the substrate-binding pocket determines alpha-chymase Phe(8) specificity.	Lysine	113-116	chymase 1	Canis lupus familiaris	164-177
10952005-10	2000	Repression of both aspartokinase and aspartate semi-aldehyde dehydrogenase gene transcription in A. mediterranei U32 by L-lysine, L-methionine, L-threonine, and L-isoleucine were found.	Lysine	120-128	2-hydroxyacid dehydrogenase	Amycolatopsis mediterranei U32	61-74
10892746-2	2000	We demonstrate that Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 self-ubiquitination.	Lysine	67-70	MDM2 proto-oncogene	Homo sapiens	20-24
10892746-2	2000	We demonstrate that Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 self-ubiquitination.	Lysine	67-70	MDM2 proto-oncogene	Homo sapiens	152-156
10860739-10	2000	AR3 of CRP also contains an inhibitory determinant: the lysine residue at position 52 of CRP is inhibitory to maximal levels of transcription activation from Class II promoters.	Lysine	56-62	catabolite gene activator protein	Escherichia coli	7-10
10860739-10	2000	AR3 of CRP also contains an inhibitory determinant: the lysine residue at position 52 of CRP is inhibitory to maximal levels of transcription activation from Class II promoters.	Lysine	56-62	catabolite gene activator protein	Escherichia coli	89-92
10859195-1	2000	Both in mammals and plants, excess lysine (Lys) is catabolized via saccharopine into alpha-amino adipic semialdehyde and glutamate by two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single bifunctional polypeptide.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	188-191
10859195-1	2000	Both in mammals and plants, excess lysine (Lys) is catabolized via saccharopine into alpha-amino adipic semialdehyde and glutamate by two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single bifunctional polypeptide.	Lysine	35-41	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	225-228
10859195-1	2000	Both in mammals and plants, excess lysine (Lys) is catabolized via saccharopine into alpha-amino adipic semialdehyde and glutamate by two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single bifunctional polypeptide.	Lysine	43-46	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	188-191
10859195-1	2000	Both in mammals and plants, excess lysine (Lys) is catabolized via saccharopine into alpha-amino adipic semialdehyde and glutamate by two consecutive enzymes, Lys-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SDH), which are linked on a single bifunctional polypeptide.	Lysine	43-46	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	225-228
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	92-95	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	0-3
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	92-95	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	33-36
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	92-95	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	37-40
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	188-191	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	0-3
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	188-191	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	33-36
10859195-3	2000	LKR activity of the bifunctional LKR/SDH possessed relatively high K(m) for its substrates, Lys and alpha-ketoglutarate, suggesting that this activity may serve as a rate-limiting step in Lys catabolism.	Lysine	188-191	lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme	Arabidopsis thaliana	37-40
10826481-2	2000	Additional mutagenesis indicates that important residues in this region for CCR5 binding are Ile-420, Lys-421, Gln-422, Pro-438, and Gly-441.	Lysine	102-105	C-C motif chemokine receptor 5	Homo sapiens	76-80
10850803-7	2000	Substitutions of the lysine at equivalent positions in two other inhibitory serpins, human alpha1-antichymotrypsin and human antithrombin III, also increased stability and decreased inhibitory activity toward alpha-chymotrypsin and thrombin, respectively.	Lysine	21-27	serpin family A member 3	Homo sapiens	91-114
10810161-12	2000	Lysine 177 could interact with the lysine-rich cluster involved in the specificity of protein kinase CK2 towards acidic substrate, thereby increasing its activity.	Lysine	35-41	Calcium-dependent protein kinase 6	Zea mays	101-104
10842705-3	2000	Direct DNA sequencing showed both a normal GAG (Glu) and a variant AAG (Lys) codon at amino acid position 89 of mature TTR, which has not been previously reported.	Lysine	72-75	transthyretin	Homo sapiens	119-122
10725088-3	2000	The structure of the oligopeptide diamine consisting of glutamic acid and lysine residues was designed as a substrate for cathepsin B, a lysosomal enzyme, which was assumed to be one of the enzymes responsible for the degradation of the polymer carrier in vivo.	Lysine	74-80	cathepsin B	Homo sapiens	122-133
11021404-0	2000	Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N. Carboxypeptidase R (EC 3.4.17.20) (CPR) and carboxypeptidase N (EC 3.4.17.3) (CPN) cleave carboxy-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.	Lysine	219-225	cytochrome p450 oxidoreductase	Rattus norvegicus	135-138
10583404-7	1999	Point mutations K25T of RhoA (numbering according to Rac1) and K27A of Cdc42 significantly increased glucosylation by the cytotoxins; introduction of lysines at the equivalent positions of Rac1 hindered modification.	Lysine	150-157	Rac family small GTPase 1	Homo sapiens	189-193
10615005-2	1999	We have now determined the kinetic parameters for hydrolysis by human and porcine tissue kallikrein, hK1 and pK1, respectively (Berg et al., 1992) of two series of intramolecularly quenched fluorogenic peptides having the sequences that flank the scissile Arg-Ser or Met-Lys bond in human and bovine kininogen.	Lysine	271-274	prokineticin 1	Homo sapiens	109-112
10514515-2	1999	Here, we report the identification in human erythroblasts of a novel cDNA, designated HUT11A, which encodes a protein identical to the previously reported erythroid HUT11 urea transporter, except for a Lys(44) --&gt; Glu substitution and a Val-Gly dipeptide deletion after proline 227, which leads to a polypeptide of 389 residues versus 391 in HUT11.	Lysine	202-205	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	86-91
10514515-2	1999	Here, we report the identification in human erythroblasts of a novel cDNA, designated HUT11A, which encodes a protein identical to the previously reported erythroid HUT11 urea transporter, except for a Lys(44) --&gt; Glu substitution and a Val-Gly dipeptide deletion after proline 227, which leads to a polypeptide of 389 residues versus 391 in HUT11.	Lysine	202-205	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	165-170
10471474-8	1999	Two internal amino acid sequences generated from lys-C digested FAA were 85% and 92% identical to the same DNase I-like protein.	Lysine	49-52	fumarylacetoacetate hydrolase	Bos taurus	64-67
10582243-9	1999	The C-terminal glycine residue of a novel modifier protein Apg12p, a 186-amino-acid protein, is conjugated to a lysine residue of Apg5p, a 294-amino-acid protein, via an isopeptide bond.	Lysine	112-118	Atg12p	Saccharomyces cerevisiae S288C	59-65
10480597-5	1999	The glucose is predicted to form hydrogen bond interactions with the side chains of glucokinase residues Thr 168, Lys 169, Asn 204, Asp 205, Asn 231, and Glu 290, similar to those observed for brain hexokinase I.	Lysine	114-117	glucokinase	Homo sapiens	84-95
10571960-12	1999	From this mutation followed the change of lysine (codon AAG) at 624 position of the polypeptide chain for glutamine (codon CAG) followed as a consequence.	Lysine	42-48	N-methylpurine DNA glycosylase	Homo sapiens	56-59
10419484-0	1999	Glycosaminoglycans mediate the coacervation of human tropoelastin through dominant charge interactions involving lysine side chains.	Lysine	113-119	elastin	Homo sapiens	53-65
10419484-6	1999	These negatively charged molecules interacted with positively charged lysine residues and promoted coacervation of tropoelastin in a temperature- and concentration-dependent manner.	Lysine	70-76	elastin	Homo sapiens	115-127
10419484-9	1999	Following lysyl oxidase modification of tropoelastin lysine residues, they are released from glycosaminoglycan interactions, thereby permitting those residues to contribute to elastin cross-links.	Lysine	53-59	elastin	Homo sapiens	40-52
10419484-9	1999	Following lysyl oxidase modification of tropoelastin lysine residues, they are released from glycosaminoglycan interactions, thereby permitting those residues to contribute to elastin cross-links.	Lysine	53-59	elastin	Homo sapiens	45-52
10387021-2	1999	Among various pancreatic PLA2s, bovine pancreatic PLA2 (bpPLA2) has a unique interfacial binding mode in which Lys-56 plays an important role in its binding to anionic lipid surfaces.	Lysine	111-114	phospholipase A2 group IIA	Homo sapiens	25-30
10358030-4	1999	Substitution of Asp10 in [Nle4]Lys-gamma2-MSH for Gly10 from [Nle4]alpha-MSH, increased both activity and affinity for the MC4R while the MC3R remained unaffected.	Lysine	31-34	melanocortin 4 receptor	Homo sapiens	123-127
10358030-7	1999	This is supported by mutagenesis of Tyr268 to Ile in the MC4R which increased affinity and activity for [Nle4]Lys-gamma2-MSH, but decreased affinity for two peptides with constrained cyclic structure of the melanocortin core sequence, MT-II and [D-Tyr4]MT-II, that also displayed lower affinity for the MC3R.	Lysine	110-113	melanocortin 4 receptor	Homo sapiens	57-61
10372548-3	1999	The substitutions observed in Cw*1507, change codon 77 from AAC (asparagine) to AGC (serine) and codon 80 from AAA (lysine) to AAC (asparagine), compared to Cw*1502.	Lysine	116-122	glycine-N-acyltransferase	Homo sapiens	60-63
10082574-7	1999	We also provide evidence showing that lysines located in helices 3 and 4, which define part of hRARalpha NCoA binding surface, contribute differently to (i) the transcriptional activity and (ii) the interaction of RXR-RAR heterodimers with SRC-1, when challenged by either natural or RAR-selective retinoids.	Lysine	38-45	retinoid X receptor alpha	Homo sapiens	214-217
10048958-8	1999	Exchanging the corresponding lysine residue in the yeast Trm1p for alanine caused a severe loss of activity, indicating that the identity of the amino acid at this position is important for enzyme activity.	Lysine	29-35	tRNA (guanine26-N2)-dimethyltransferase	Saccharomyces cerevisiae S288C	57-62
9876119-7	1999	Positively charged surface regions of aldolase (residues Lys 13, 27, 288, 293, and 341 and Arg 257) are attracted to the negatively charged amino terminus (Asp 1 and Glu 2 and 4) and other patches (Asp 24, 25, and 363 and Glu 361, 364, 99, and 100) of actin subunits.	Lysine	57-60	beta-secretase 2	Homo sapiens	156-161
9868191-12	1998	Overall, LKR and SacD were 6-107 times that of LOX, suggesting that, in liver, mitochondrial lysine uptake limits LOX.	Lysine	93-99	lysyl oxidase	Rattus norvegicus	47-50
9868191-12	1998	Overall, LKR and SacD were 6-107 times that of LOX, suggesting that, in liver, mitochondrial lysine uptake limits LOX.	Lysine	93-99	lysyl oxidase	Rattus norvegicus	114-117
9822825-3	1998	Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3.	Lysine	109-115	amino acid transporter BAP3	Saccharomyces cerevisiae S288C	183-187
9778308-2	1998	In this study, the structure of a previously uncharacterized stable protein cross-link produced by CS2 in vivo involving lysine and the N-terminal valine of globin has been determined.	Lysine	121-127	calsyntenin 2	Rattus norvegicus	99-102
9778308-9	1998	These observations demonstrate the potential of thiourea cross-linking involving a free amino terminus and epsilon-amino groups of lysine to accumulate in a long-lived globular protein and suggest that cross-linking of globin may provide a specific dosimeter of internal exposure for CS2 capable of assessing exposure over subchronic periods.	Lysine	131-137	calsyntenin 2	Rattus norvegicus	284-287
9774110-8	1998	Moreover, our data show that dCBP acetylates a conserved lysine in the Armadillo-binding domain of dTCF, and that this acetylation lowers the affinity of Armadillo binding to dTCF.	Lysine	57-63	pangolin	Drosophila melanogaster	99-103
9759731-6	1998	The carboxy-terminal glycine residue of Apg12, a 186-amino-acid protein, is conjugated to a lysine at residue 149 of Apg5, a 294-amino-acid protein.	Lysine	92-98	Atg12p	Saccharomyces cerevisiae S288C	40-45
9879009-4	1998	The imbalance for lysine and tryptophan reduced the stability of the total polyadenylated mRNA and the eEF-1 alpha mRNA of rat liver.	Lysine	18-24	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	103-114
9761475-2	1998	K1, K2, K4, and K5 contain each a lysine-binding site (LBS).	Lysine	34-40	keratin 1	Rattus norvegicus	0-2
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Lysine	210-216	TATA-box binding protein	Homo sapiens	299-302
9668079-3	1998	The specific activities of the URA7-encoded and URA8-encoded enzymes with a Glu161 --&gt; Lys (E161K) mutation were 2-fold greater when compared with the wild-type enzymes.	Lysine	90-93	CTP synthase URA8	Saccharomyces cerevisiae S288C	48-52
9688537-1	1998	Mutating the histidine at position 55 present at the subunit interface of the tetrameric E. coli single stranded DNA binding (SSB) protein to tyrosine or lysine leads to cells which are UV- and temperature-sensitive.	Lysine	154-160	single-stranded DNA-binding protein	Escherichia coli	126-129
9675061-3	1998	We have now improved the expression of TP2 over fivefold by (1) optimizing the codons for lysine, arginine, proline, leucine, glycine, valine, threonine, alanine, and tyrosine and (2) by engineering the vector-encoded 5" UTR.	Lysine	90-96	transition protein 2	Rattus norvegicus	39-42
9642086-0	1998	An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.	Lysine	7-10	TARBP2 pseudogene 1	Homo sapiens	36-40
9614108-3	1998	The coreceptor activity of the second extracellular loop of CXCR4, which is restricted to dual tropic and T-tropic strains, was insensitive to the removal of charged residues either singly or in combinations by alanine scanning mutagenesis or to the conversion of acidic residues to lysine.	Lysine	283-289	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
9592082-3	1998	Most phosphorylation occurs in the lys-ser-pro (KSP) repeats in the C-terminal tail domains of NF-H and NF-M.	Lysine	35-38	neurofilament heavy chain	Rattus norvegicus	95-99
9585559-0	1998	Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70.	Lysine	87-93	heat shock protein family A (Hsp70) member 8	Bos taurus	127-132
9572863-3	1998	Here we report that the Lys-72 residue of this enzyme is the catalytic center for dRP excision.	Lysine	24-27	drp	Drosophila melanogaster	82-85
9572863-4	1998	Substitutions of Lys-72 with Arg or Gln reduced the dRP excision activity to less than 1% of the wild-type 8-kDa domain, while substitutions of Lys-35, Lys-68, or Lys-84 did not abolish its activity.	Lysine	17-20	drp	Drosophila melanogaster	52-55
9572863-10	1998	These results indicate a specific role of Lys-72 of pol beta in the dRP excision during base excision repair.	Lysine	42-45	drp	Drosophila melanogaster	68-71
9635276-7	1998	In addition, these isoforms all contain the four residue PP1c-binding motif (Arg/Lys-Val/Ile-Xaa-Phe).	Lysine	81-84	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	57-61
9572144-8	1998	A deletion of RPD3 or SIN3, but not of the related histone-deacetylase gene HDA1, results in increased acetylation of the lysine 5 residue of H4 in the promoters of the UME6-regulated INO1, IME2 and SPO13 genes.	Lysine	122-128	Spo13p	Saccharomyces cerevisiae S288C	199-204
9507015-10	1998	The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin.	Lysine	123-136	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
9494104-10	1998	Both the Yap3 and Mkc7 proteases preferred to cleave at a single Glu-Lys downward arrow-Glu-Arg site.	Lysine	69-72	aspartyl protease	Saccharomyces cerevisiae S288C	18-22
9494104-11	1998	Analysis of secondary cleavage sites showed that Yap3 preferred to cleave after either Lys or Arg and Mkc7 after Lys.	Lysine	113-116	aspartyl protease	Saccharomyces cerevisiae S288C	102-106
9482942-4	1998	We show that a single asparagine --&gt; lysine substitution of the rat muscle Na+ channel alpha-subunit, mu1-N434K, renders the channel completely insensitive to 5 microM BTX when expressed in mammalian cells.	Lysine	40-46	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	78-108
9460938-4	1998	Tobacco etch virus (TEV) mutants with substitutions of Lys for Asp in the two DAG motifs near the CP N terminus also failed to infect tobacco plants systemically, and in situ histochemical analysis showed limited movement.	Lysine	55-58	carboxypeptidase N subunit 1	Homo sapiens	98-102
9406398-4	1997	Lysine overproduction by one of the mutants seemed to be due to, at least, the loss of repression of the homocitrate synthase encoded by the LYS20 gene.	Lysine	0-6	homocitrate synthase LYS20	Saccharomyces cerevisiae S288C	141-146
9401066-6	1997	Amplification of this region by PCR and subsequent DNA sequencing demonstrated a single base substitution altering the normal 380 Lys (AAG) codon to Asn (AAT), producing a new Asn-Lys-Thr glycosylation site.	Lysine	130-133	N-methylpurine DNA glycosylase	Homo sapiens	135-138
9452365-4	1997	Replacement of lysines at positions 34, 107, 121, and 132 in Bo-IFN-tau, which are in regions predicted to interact with the type I receptor, led to modest but significant alterations in antiproliferative (AP) and AV activities.	Lysine	15-22	interferon-tau-like	Bos taurus	64-71
9548475-7	1997	Thus, the carboxyl-terminal five amino acids, Lys-Tyr-Glu-Gly-Lys (KYEGK), of the beta1 integrin cytoplasmic domain are critical for the coordinate tyrosine phosphorylation of three non-FAK substrates in human T cells.	Lysine	46-49	integrin subunit beta 1	Homo sapiens	82-96
9548475-7	1997	Thus, the carboxyl-terminal five amino acids, Lys-Tyr-Glu-Gly-Lys (KYEGK), of the beta1 integrin cytoplasmic domain are critical for the coordinate tyrosine phosphorylation of three non-FAK substrates in human T cells.	Lysine	62-65	integrin subunit beta 1	Homo sapiens	82-96
9398839-3	1997	Two mutations, a C--&gt;T substitution that changes the Arg 257 (CGA) to a stop codon (TGA) and an A--&gt;G substitution that changes the Lys 83 (AAG) to a Glu codon (GAG), were found in this novel gene in Swiss and Finnish APECED patients.	Lysine	138-141	N-methylpurine DNA glycosylase	Homo sapiens	146-149
9371758-1	1997	Lysyl oxidase (EC 1.4.3.13) oxidizes peptidyl lysine to peptidyl aldehyde residues within collagen and elastin, thus initiating formation of the covalent cross-linkages that insolubilize these extracellular proteins.	Lysine	46-52	lysyl oxidase	Rattus norvegicus	0-13
9371758-1	1997	Lysyl oxidase (EC 1.4.3.13) oxidizes peptidyl lysine to peptidyl aldehyde residues within collagen and elastin, thus initiating formation of the covalent cross-linkages that insolubilize these extracellular proteins.	Lysine	46-52	elastin	Rattus norvegicus	103-110
9401778-9	1997	A role for cyclic GMP as a mediator of chemotaxis was supported by the finding that the guanylyl cyclase inhibitor LY 83583 (100 microM) completely inhibited chemotaxis and suppressed the maximal response; EC50 for fMLP 32.53 +/- 11.18 and 85.21 +/- 15.14 pmol/10(6) cells with and without LY 83583, respectively.	Lysine	115-117	5'-nucleotidase, cytosolic II	Homo sapiens	18-21
9431811-1	1997	We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the third alpha-helix of the homeodomain.	Lysine	210-216	paired-like homeodomain transcription factor 1	Mus musculus	78-82
9369369-11	1997	MK-801 and LY 235959 reverse delta1- and delta2-opioid receptor agonists-induced down-regulation of brain delta1-opioid receptor, respectively, apparently by different mechanisms.	Lysine	11-13	opioid receptor, delta 1	Mus musculus	29-63
9369369-11	1997	MK-801 and LY 235959 reverse delta1- and delta2-opioid receptor agonists-induced down-regulation of brain delta1-opioid receptor, respectively, apparently by different mechanisms.	Lysine	11-13	opioid receptor, delta 1	Mus musculus	106-128
9300481-3	1997	At the specificity-determining site of these inhibitors (P1), residue 15(I)4 is an arginine in APPI and a lysine in BPTI, residue types that are counter to the chymotryptic hydrophobic specificity.	Lysine	106-112	spleen trypsin inhibitor I	Bos taurus	116-120
9207119-3	1997	In this study, we report the cDNA cloning of human and murine FYB and show that it is restricted in expression to T cells and myeloid cells and possesses an overall unique hydrophilic sequence with several tyrosine-based motifs, proline-based type I and type II SH3 domain binding motifs, several putative lysine/glutamic acid-rich nuclear localization motifs, and a SH3-like domain.	Lysine	306-312	FYN binding protein	Mus musculus	62-65
9271317-2	1997	The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT, with promiscuous binding to multiple MHC class II alleles, reduces the incidence, onset and severity of disease in the BIO.D2 --&gt; BALB/c model of lethal GVHD.	Lysine	58-63	major histocompatibility complex, class I, C	Homo sapiens	132-135
29512538-6	1997	Argine and lysine residues were involved in the agglutination activity of MBP.	Lysine	11-17	myelin basic protein	Rattus norvegicus	74-77
9192308-9	1997	The dopamine precursor L-beta-3,4-dihydroxyphenylalanine (L-DOPA) inhibited cleavage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with COOH-terminal glycine, i.e. [35S]G34-Gly, at a pair of lysine residues, but did not influence cleavage of progastrin at pairs of arginine residues.	Lysine	233-239	gastrin	Rattus norvegicus	133-140
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Lysine	189-192	carboxypeptidase N subunit 1	Homo sapiens	17-42
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Lysine	189-192	carboxypeptidase N subunit 1	Homo sapiens	44-48
9162090-8	1997	Plasminogen-binding sites (C-terminal lysines) on the surface of a plasmin-treated fibrin clot were eliminated within 1-3 min by plasma with maximally activated pCPB, as studied in a recently described model involving fluorescence microscopy.	Lysine	38-45	carboxypeptidase N subunit 1	Homo sapiens	161-165
9148914-5	1997	A detailed kinetic analysis of AAP5 using lysine, alanine, glutamate, and histidine revealed H+-dependent differences in the apparent affinity constants for each substrate.	Lysine	42-48	amino acid permease 5	Arabidopsis thaliana	31-35
9153272-3	1997	A plausible mechanism for this inhibitory effect of thrombin involves TAFI (thrombin-activatable fibrinolysis inhibitor, procarboxypeptidase B) which, upon activation, may inhibit fibrinolysis by removing carboxy-terminal lysines from fibrin.	Lysine	222-229	carboxypeptidase B1	Homo sapiens	121-142
9065421-5	1997	In contrast, lysine 114 was found to be critical in the activation of ATIII toward factor Xa.	Lysine	13-19	coagulation factor X	Homo sapiens	83-92
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	90-93	aminolevulinate dehydratase	Homo sapiens	147-151
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	90-93	aminolevulinate dehydratase	Homo sapiens	177-181
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	128-131	aminolevulinate dehydratase	Homo sapiens	147-151
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	128-131	aminolevulinate dehydratase	Homo sapiens	177-181
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	128-131	aminolevulinate dehydratase	Homo sapiens	147-151
9033406-5	1997	The amino acid residue modified by ALA was identified by MALDI-MS and Edman sequencing as Lys-293, analogous to the active site Lys-247 of E. coli ALAD and Lys-252 of mammalian ALAD.	Lysine	128-131	aminolevulinate dehydratase	Homo sapiens	177-181
9032446-3	1997	In contrast, Lys-174 is conserved except in a yeast isoenzyme, fbp26, where it is replaced by glycine.	Lysine	13-16	fructose-2,6-bisphosphatase	Saccharomyces cerevisiae S288C	63-68
9599662-4	1997	Two isoforms of calcyclin (A and B), which differ with respect to the presence or absence of a C-terminal lysine, were identified and the native protein was shown to exist as noncovalently associated homodimers (AA and BB) and heterodimers (AB).	Lysine	106-112	S100 calcium binding protein A6	Gallus gallus	16-25
9037719-7	1997	In addition, TCH2 is enriched in Lys and Arg residues relative to other CaMs, suggesting a preference for targets which are more negatively charged.	Lysine	33-36	EF hand calcium-binding protein family	Arabidopsis thaliana	13-17
8985148-4	1996	Lowering the growth temperature, and reducing the amount of inducer, resulted in the production of soluble LO, which was active on a degrees [3H]lysine-labeled elastin substrate.	Lysine	145-151	elastin	Homo sapiens	160-167
8962081-8	1996	We find that both hda1 and rpd3 deletions increase acetylation levels in vivo at all sites examined in both core histones H3 and H4, with rpd3 deletions having a greater impact on histone H4 lysine positions 5 and 12.	Lysine	191-197	histone deacetylase HDA1	Saccharomyces cerevisiae S288C	18-22
8875911-3	1996	In P suspensions, mixed DAP-SI decreased by 10.59% as a whole and converted mainly to lysine by 8.41% during 12 h incubation.	Lysine	86-92	death-associated protein 1	Capra hircus	24-30
8875911-4	1996	When meso-, L- and D-DAP were added singly to the media, the results showed that each DAP-SI interconverted and produced lysine.	Lysine	121-127	death-associated protein 1	Capra hircus	86-92
8875911-5	1996	This means that mixed rumen protozoa have an ability to synthesize lysine from not only meso-DAP but also from D- and L-DAP, though probably via meso-DAP, and hence have DAP epimerase activities for the reversal conversion of each DAP-SI.	Lysine	67-73	death-associated protein 1	Capra hircus	231-237
8857956-8	1996	Competition studies with lysine indicated that the binding was largely kringle-dependent, and when binding of tPA to actin was assessed, it also bound to actin with 70-80% of binding inhibited by lysine.	Lysine	25-31	chromosome 20 open reading frame 181	Homo sapiens	110-113
8857956-8	1996	Competition studies with lysine indicated that the binding was largely kringle-dependent, and when binding of tPA to actin was assessed, it also bound to actin with 70-80% of binding inhibited by lysine.	Lysine	196-202	chromosome 20 open reading frame 181	Homo sapiens	110-113
8836175-2	1996	The open reading frame of RNase k6, amplified from human genomic DNA, encodes a 150 amino acid polypeptide with eight cysteines and histidine and lysine residues corresponding to those found in the active site of the prototype, ribonuclease A.	Lysine	146-152	ribonuclease A family member k6	Homo sapiens	26-34
8697449-1	1996	Deoxyhpusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor using spermidine as the substrate.	Lysine	50-56	eukaryotic translation initiation factor 5A2	Mus musculus	89-120
8697449-1	1996	Deoxyhpusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor using spermidine as the substrate.	Lysine	50-56	eukaryotic translation initiation factor 5A2	Mus musculus	122-128
8866020-5	1996	In the present study, cDNA encoding countertrypin was isolated and sequenced, and evidence is presented, based on the site-directed mutagenesis, that lysine-231 in the second cystatin domain is the P1 site for trypsin inhibition.	Lysine	150-156	alpha-2-HS-glycoprotein	Mus musculus	36-49
8769411-11	1996	Furthermore, through the use of the two-hybrid system, it was demonstrated that both the PAS10 gene product (Pas10p) and the human PTS1 receptor can interact with the COOH-terminal region of human catalase, but that this interaction is abolished by substitutions at the penultimate residue (asparagine-to- aspartate) and at the fourth residue from the COOH terminus (lysine-to-glycine) which abolish PTS functionality.	Lysine	367-373	Pex5p	Saccharomyces cerevisiae S288C	89-94
8754806-1	1996	Thanatophoric dysplasia type II (TDII) is a neonatal lethal skeletal dysplasia caused by a recurrent Lys-650--&gt;Glu mutation within the highly conserved activation loop of the kinase domain of fibroblast growth factor receptor 3 (FGFR3).	Lysine	101-104	fibroblast growth factor receptor 3	Homo sapiens	195-230
8647209-6	1996	The induction of uropod formation by IL-15 was observed on T lymphoblasts adhering to the integrin ligands fibronectin, vascular cell adhesion molecule (VCAM)-1 and ICAM-1, but not to bovine serum albumin or poly-L-lysine.	Lysine	208-221	interleukin 15	Homo sapiens	37-42
8654567-5	1996	It is thus found that the interaction of alpha2-antiplasmin with the lysine-binding site of kringle 1 is of little importance compared with that of kringle 4 in regulating the inhibition reaction of plasmin with alpha2-antiplasmin.	Lysine	69-75	serpin family F member 2	Homo sapiens	41-59
8645216-5	1996	Several members of the family of MUP sequences differ in only four positions, and in some circumstances the substitutions elicit a minimal change in protein mass (Lys/Gln; Lys/Glu).	Lysine	163-166	major urinary protein 21	Mus musculus	33-36
8645216-5	1996	Several members of the family of MUP sequences differ in only four positions, and in some circumstances the substitutions elicit a minimal change in protein mass (Lys/Gln; Lys/Glu).	Lysine	172-175	major urinary protein 21	Mus musculus	33-36
8643504-10	1996	Inclusion of carboxypeptidase E (CPE) in the reaction greatly diminished the inhibitory potency of the CT peptide against PC2, in line with the notion that the CT peptide cleavage product is not inhibitory after the removal of terminal lysines by CPE.	Lysine	236-243	carboxypeptidase E	Mus musculus	33-36
8928931-4	1996	Systemic administration of LY-215490 produced a dose-dependent decrease in the number of Fos-positive cells after LUT irritation in the DCM and SPN areas, whereas in the DH only the highest dose (10 mg/kg) of LY-215490 decreased the number of Fos-positive cells.	Lysine	27-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	89-92
8928931-4	1996	Systemic administration of LY-215490 produced a dose-dependent decrease in the number of Fos-positive cells after LUT irritation in the DCM and SPN areas, whereas in the DH only the highest dose (10 mg/kg) of LY-215490 decreased the number of Fos-positive cells.	Lysine	27-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	243-246
8928931-6	1996	However, a combined administration of low doses of MK-801 and LY-215490 significantly decreased the number of Fos-positive cells in all regions of the spinal cord.	Lysine	62-64	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-113
8625852-4	1996	We demonstrate that an alternately spliced exon (encoding the sequence lysine, serine, arginine, lysine: Y site) is necessary for agrin-heparin interactions.	Lysine	71-77	agrin	Homo sapiens	130-135
8625852-4	1996	We demonstrate that an alternately spliced exon (encoding the sequence lysine, serine, arginine, lysine: Y site) is necessary for agrin-heparin interactions.	Lysine	97-103	agrin	Homo sapiens	130-135
8661009-7	1996	Another unexpected finding is that the deduced amino acid sequences of PON2 in human, mouse, dog, turkey, and chicken and of human PON3 are all missing the amino acid residue 105, which is lysine in human PON1.	Lysine	189-195	paraoxonase 2	Homo sapiens	71-75
8661009-7	1996	Another unexpected finding is that the deduced amino acid sequences of PON2 in human, mouse, dog, turkey, and chicken and of human PON3 are all missing the amino acid residue 105, which is lysine in human PON1.	Lysine	189-195	paraoxonase 3	Homo sapiens	131-135
8792334-4	1996	MAP1 kinase A is a novel protein kinase that is remarkably activated by poly-L-lysine and poly-L-arginine, but very insensitive to heparin among the kinases.	Lysine	72-85	kininogen 2	Rattus norvegicus	0-4
8621437-2	1996	Replacement of lysine 72 in RecA protein with arginine produces a mutant protein that binds but does not hydrolyze ATP.	Lysine	15-21	RAD51 recombinase	Homo sapiens	28-32
8915539-2	1996	In the yeast Saccharomyces cerevisiae, one of the three lysine isoacceptors, the tRNA(Lys)1 with the anticodon CUU (tRNA-K1), is encoded by the nuclear genome and distributed between the cytoplasmic (&gt; 95%) and mitochondrial (&lt; 5%) compartments.	Lysine	56-62	saccharopine dehydrogenase (NAD+, L-lysine-forming)	Saccharomyces cerevisiae S288C	81-91
9225234-3	1996	Sequence analysis of PCR-amplified DNA from the proband of apo A-I Nanakuma2 revealed a three-base (AAG or AGA) deletion between bases 186 and 193 from the 5" end of exon 4 that leads to deletion of Lys 106 or 107.	Lysine	199-202	N-methylpurine DNA glycosylase	Homo sapiens	100-103
8530448-7	1995	When u-PA or ATF was treated with immobilized carboxypeptidase B, its proadhesive effect was abolished, implicating the involvement of carboxyl-terminal lysine residues (Lys158 on u-PA and Lys135 on ATF).	Lysine	153-159	carboxypeptidase B1	Homo sapiens	46-64
8530448-8	1995	Moreover, when a carboxyl-terminal lysine analog was added, the proadhesive effect of carboxypeptidase B-treated u-PA or ATF was restored.	Lysine	35-41	carboxypeptidase B1	Homo sapiens	86-104
8655442-13	1995	Inflection point analysis projected maximum ADG at methionine:lysine ratios of 27 and 27.5% for pigs fed 1.4 and 1.8% lysine, respectively.	Lysine	62-68	ADG	Sus scrofa	44-47
7479877-4	1995	Overexpression of MKC7 resulted in production of a membrane-associated proteolytic activity that cleaved an internally quenched fluorogenic peptide substrate on the carboxyl side of a Lys-Arg site.	Lysine	184-187	aspartyl protease	Saccharomyces cerevisiae S288C	18-22
15299773-3	1995	The mechanistic heart of the complex is provided by the lipoic acid attached to a lysine residue of the H-protein.	Lysine	82-88	myosin binding protein H	Homo sapiens	104-113
7548083-6	1995	Specifically, the pH dependence of MLT 15N chemical shifts was measured separately for the isotopically enriched backbone nitrogen of Gly-1 and the side chain nitrogen atoms of Lys-7, Lys-21, and Lys-23 at a MLT concentration of 1.2 mM and a temperature of 23 degrees C. Measurements were made for MLT in potassium phosphate buffer, in neat water, and in 1-myristoyl-2-hydroxyl-sn-glycero-3-phosphocholine (MMPC) lipid micelles.	Lysine	184-187	melittin	Apis mellifera	35-38
7548083-6	1995	Specifically, the pH dependence of MLT 15N chemical shifts was measured separately for the isotopically enriched backbone nitrogen of Gly-1 and the side chain nitrogen atoms of Lys-7, Lys-21, and Lys-23 at a MLT concentration of 1.2 mM and a temperature of 23 degrees C. Measurements were made for MLT in potassium phosphate buffer, in neat water, and in 1-myristoyl-2-hydroxyl-sn-glycero-3-phosphocholine (MMPC) lipid micelles.	Lysine	184-187	melittin	Apis mellifera	35-38
7548083-7	1995	The experiments showed for MLT tetramer in aqueous phosphate buffer that the amino nitrogen of Gly-1 has a pKa of 8.15, and that the Lys-7, Lys-21, and Lys-23 side chain nitrogen atoms have pKa values of 10.21, 10.03, and 10.24 respectively.	Lysine	133-136	melittin	Apis mellifera	27-30
8585284-1	1995	We examined the effect of MDP-Lys(L18), a lipophilic derivative of muramyl dipeptide, on the enhancement of host resistance against virus infection in newborn mice.	Lysine	30-33	ribosomal protein L18	Mus musculus	34-37
7665587-5	1995	Thus, endopeptidase 24-15 exhibits a marked preference for inhibitors containing a basic residue (Arg or Lys) in the P2" position, while 24-16 prefers a proline in this position.	Lysine	105-108	thimet oligopeptidase 1	Rattus norvegicus	6-25
7545663-8	1995	pH titration experiments of CaM dimethylated with [13C]formaldehyde show that Lys-75 (and Lys-148) experience a large increase in pKa upon peptide binding; this indicates an unraveling of part of the helical linker region of CaM upon cNOS peptide binding.	Lysine	78-81	nitric oxide synthase 3	Rattus norvegicus	234-238
8564412-2	1995	A N alpha-blocked, Aib-rich octapeptide methylamide containing two N omega-benzoylated L-Lys residues at positions 3 and 6 was synthesized by solution methods and fully characterized.	Lysine	87-92	ANIB1	Homo sapiens	19-22
7662676-4	1995	In the present study, we acetylated the epsilon-NH2 groups of the nine lysines of TnC in order to avoid complications which may arise from intramolecular cross-linking between NH2 and COOH groups of TnC.	Lysine	71-78	tenascin C	Homo sapiens	82-85
7662676-4	1995	In the present study, we acetylated the epsilon-NH2 groups of the nine lysines of TnC in order to avoid complications which may arise from intramolecular cross-linking between NH2 and COOH groups of TnC.	Lysine	71-78	tenascin C	Homo sapiens	199-202
7650691-3	1995	Incorporation of the Lys(Tac) side chain into 3 produced the novel agonist analog 7 (EC50 = 28 nM in the GPGB) with excellent affinity for both human CCK-A (IC50 = 12 nM) and CCK-B (IC50 = 17 nM) receptors.	Lysine	21-24	cholecystokinin A receptor	Homo sapiens	150-155
7608199-5	1995	AAP3 and AAP5 efficiently transport arginine and lysine and are involved in basic amino acid transport.	Lysine	49-55	amino acid permease 5	Arabidopsis thaliana	9-13
8578451-3	1995	Plasminogen activation for clot lysis is regulated by specific molecular interactions between tissue-type plasminogen activator (t-PA), plasminogen and fibrin, whereby the lysine-binding sites of the plasminogen molecule play a crucial role by mediating its binding to fibrin, and by controlling the inhibition rate of plasmin by alpha 2-antiplasmin.	Lysine	172-178	serpin family F member 2	Homo sapiens	330-349
7538115-5	1995	Electrospray mass spectrometry and amino acid sequencing indicated the 16-kDa fragment spanned the NH2 terminus of native IGFBP-4 through Lys-120.	Lysine	138-141	insulin like growth factor binding protein 4	Homo sapiens	122-129
7630158-8	1995	The histochemical experiments with biotinylated ET-1 at lysine-9 side chain alone or in combination with unlabeled ET-1, BQ123, Ro 46-2005, or IRL1620, showed the ETA receptors to be localized mainly in the media, whereas the ETB receptors localized mainly in the neointima.	Lysine	56-62	endothelin-1	Oryctolagus cuniculus	48-52
7721857-8	1995	Only the cdc34-2 allele, however, could be suppressed by Ub with an amino acid substitution at lysine 48 which is known to be involved in multi-Ub chain assembly.	Lysine	95-101	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	9-14
7713939-2	1995	To investigate the function of protein kinase C (PKC)-delta, we mutated its ATP binding site by converting the invariant lysine in the catalytic domain (amino acid 376) to an arginine.	Lysine	121-127	protein kinase C, delta	Mus musculus	31-59
7706481-3	1995	Both MBP and poly-L-lysine induced a three- and eightfold increase in levels of kallikrein-like activity and i-kinins, respectively.	Lysine	13-26	kallikrein related peptidase 4	Homo sapiens	80-90
7706481-6	1995	Our results demonstrate that MBP and poly-L-lysine activate kallikrein and stimulate the generation of i-kinins in vivo, an effect that may be related to the cationic charge of these proteins.	Lysine	37-50	kallikrein related peptidase 4	Homo sapiens	60-70
7720578-12	1995	Microinjected transcripts of Xotx2 constructs containing a homeodomain where this lysine is substituted by a glutamine or a glutamic acid residue fail to cause these effects.	Lysine	82-88	orthodenticle homeobox 2 S homeolog	Xenopus laevis	29-34
7853501-6	1995	NS1 molecules with mutations in a critical lysine residue (amino acid 405) in the consensus ATP-binding site bound to the origin, but this binding could not be enhanced by ATP addition.	Lysine	43-49	influenza virus NS1A binding protein	Homo sapiens	0-3
7853520-6	1995	We also describe the expression, purification, and characterization of a mutant NS-1 protein, in which a lysine in the putative nucleotide binding consensus sequence of the molecule was replaced with serine.	Lysine	105-111	influenza virus NS1A binding protein	Homo sapiens	80-84
7819186-10	1995	A mutant CK2 alpha in which glutamic acids replace two lysine residues in positions 75 and 76 of the alpha peptide chain is less susceptible to DNA inhibition, indicating that this basic region of the molecule is involved in its interaction with DNA.	Lysine	55-61	casein kinase 2 alpha 2	Homo sapiens	9-18
7999753-0	1994	Residue lysine-34 in GroES modulates allosteric transitions in GroEL.	Lysine	8-14	heat shock protein family D (Hsp60) member 1	Homo sapiens	63-68
7999753-10	1994	They suggest that Lys-34 in GroES modulates the allosteric transition in GroEL by stabilizing a relaxed (R)-like state.	Lysine	18-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	73-78
7830718-10	1994	In merodiploid studies, lysine-439 mutations present in trans decreased IncQ plasmid transfer frequencies, suggesting that VirB4 functions within a complex to facilitate DNA transfer.	Lysine	24-30	type IV secretion system protein VirB4	Agrobacterium tumefaciens	123-128
7961823-7	1994	Lp(a) assembly required lysine-binding pockets in apo(a) kringles, as it was inhibited by the lysine analog, 6-amino hexanoic acid.	Lysine	24-30	apolipoprotein(a)	Papio anubis	0-5
7961823-7	1994	Lp(a) assembly required lysine-binding pockets in apo(a) kringles, as it was inhibited by the lysine analog, 6-amino hexanoic acid.	Lysine	24-30	apolipoprotein(a)	Papio anubis	50-56
7961823-7	1994	Lp(a) assembly required lysine-binding pockets in apo(a) kringles, as it was inhibited by the lysine analog, 6-amino hexanoic acid.	Lysine	94-100	apolipoprotein(a)	Papio anubis	0-5
7961823-7	1994	Lp(a) assembly required lysine-binding pockets in apo(a) kringles, as it was inhibited by the lysine analog, 6-amino hexanoic acid.	Lysine	94-100	apolipoprotein(a)	Papio anubis	50-56
7929433-9	1994	We conclude that cross-linking between IGF-II and its receptor involves one or more of the 4 lysine residues located within extracellular repeat 11.	Lysine	93-99	insulin like growth factor 2	Bos taurus	39-45
7945373-2	1994	Its nucleotide sequence predicts a preprocorazonin consisting of an 19 amino acid putative signal peptide, the 11 amino acid corazonin sequence, a Gly used for amidation, a Lys-Arg proteolytic processing site, and a 39 amino acid corazonin-precursor-related peptide (CPRP).	Lysine	173-176	Corazonin	Drosophila melanogaster	41-50
24177888-2	1994	The opaque-2 mutation conditions a reduction in the amount of zein seed storage protein; zeins are deficient in the essential amino acids lysine and tryptophan, and mutant seed have a higher nutritional value.	Lysine	138-144	regulatory protein opaque-2	Zea mays	4-12
8060346-3	1994	The mutation at nucleotide pair 7444 converts stop codon AGA into lysine codon AAA (human mitochondrial genetic code).	Lysine	66-72	AAA1	Homo sapiens	79-82
8049275-3	1994	Mosquito rpL31 had a mass of 15,137 Da, a pI of 12.39 and contained 14.5% Arg and 14.5% Lys.	Lysine	88-91	ribosomal protein L31	Rattus norvegicus	9-14
8038158-1	1994	In the crystalline CcP-yCC complex, two acidic regions of CcP contact lysine residues on yCC.	Lysine	70-76	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	19-22
8038158-1	1994	In the crystalline CcP-yCC complex, two acidic regions of CcP contact lysine residues on yCC.	Lysine	70-76	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	58-61
8038158-7	1994	CcP mutants D34N and E290N that are closest to a complementary yCC lysine residue in the crystalline CcP-yCC complex gave the lowest values for ka and kb, which were 25-50% of the values of the CcP parent.	Lysine	67-73	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	0-3
8038158-7	1994	CcP mutants D34N and E290N that are closest to a complementary yCC lysine residue in the crystalline CcP-yCC complex gave the lowest values for ka and kb, which were 25-50% of the values of the CcP parent.	Lysine	67-73	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	101-104
8038158-7	1994	CcP mutants D34N and E290N that are closest to a complementary yCC lysine residue in the crystalline CcP-yCC complex gave the lowest values for ka and kb, which were 25-50% of the values of the CcP parent.	Lysine	67-73	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	101-104
8208547-3	1994	A substitution of the conserved lysine in the catalytic domain abolished kinase activity and the transforming potential of Tpr-Met demonstrating the requirement for kinase activity for transformation.	Lysine	32-38	translocated promoter region, nuclear basket protein	Homo sapiens	123-126
7926734-6	1994	Three independently isolated derivatives of human TBP that permit yeast cell growth replace arginine 231 with lysine; the corresponding amino acid in yeast TBP (lysine 133) has been implicated in RNA polymerase III transcription.	Lysine	110-116	TATA-box binding protein	Homo sapiens	50-53
7915226-6	1994	One allele (NAT2(191)) contained a point mutation at nucleotide 191 [G--&gt;A (Arg--&gt;Gln)], whereas the other allele (NAT2(341/803)) contained two point mutations [341T--&gt;C (Ile--&gt;Thr); 803A--&gt;G (Lys--&gt;Arg)].	Lysine	208-211	N-acetyltransferase 2	Homo sapiens	12-16
8142399-14	1994	The P1 Arg and Lys mutants also significantly inhibited thrombin, factor XIa, activated protein C, plasmin, factor XIIa, kallikrein, and bovine trypsin and chymotrypsin but did not inhibit tissue factor.factor VIIa, t-PA, or HLE.	Lysine	15-18	coagulation factor II, thrombin	Bos taurus	56-119
8168536-9	1994	When positive charges of four lysines in the amino-terminal region of A.h. blomhoffii PLA2 were neutralized by limited carbamoylation, heparin neither bound the carbamoylated A.h. blomhoffii PLA2 nor inhibited the hydrolysis of Triton X-100/dilauroylglycerophosphocholine mixed micelles by the carbamoylated A.h. blomhoffii PLA2 that retained 50% activity of native A.h. blomhoffii PLA2.	Lysine	30-37	phospholipase A2 group IIA	Homo sapiens	86-90
8168536-11	1994	piscivorus PLA2 in which two lysines in the amino-terminal alpha-helix are acylated.	Lysine	29-36	phospholipase A2 group IIA	Homo sapiens	11-15
8069491-2	1994	The predicted ER10 and ERD14 polypeptides have a compositional bias towards Glu (19.62% and 21.08%, respectively) and Lys (16.15% and 18.38%, respectively) and both lack Trp and Cys residues.	Lysine	118-121	Dehydrin family protein	Arabidopsis thaliana	23-28
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	11-17	carboxypeptidase B1	Homo sapiens	72-90
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	carboxypeptidase B1	Homo sapiens	72-90
8112348-7	1994	Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2.	Lysine	184-190	carboxypeptidase B1	Homo sapiens	72-90
8170472-5	1994	In contrast, either a C-terminal truncation of 46 amino acids (delta 382-427) or single point mutations at lysine-382, methionine-383, glutamine-385, or leucine-390 dramatically reduced the ability of hVDR to heterodimerize with RAF.	Lysine	107-113	vitamin D receptor	Homo sapiens	201-205
8294457-8	1994	The enzyme produced such a cleavage at the Arg-Lys doublet of somatostatin 28 (Km = 43 microM), at the Arg-Arg doublet of dynorphin A (Km = 6.45 microM) and atrial natriuretic factor (Km = 6.25 microM), and at the Lys-Arg doublet of preproneurotensin-(154-170) (Km = 17.3 microM).	Lysine	47-50	natriuretic peptide A	Rattus norvegicus	157-182
8276107-1	1994	We made a mutated progastrin cDNA construct that contains a cleavage site (-Arg(-4)-Arg(-3)-Lys(-2)-Arg-1) specific for the Kex2-like endoprotease furin, located ahead of the bioactive gastrin.	Lysine	92-95	gastrin	Cricetulus griseus	21-28
8259645-13	1994	The SVMPA mutation at nt 120, which is associated with the host range phenotype, changes Gln21 of nsP1 to Lys.	Lysine	106-109	SH2 domain containing 3A	Homo sapiens	98-102
8227016-13	1993	In contrast to the results with DFMO, the C360A mutant ODC was completely resistant to inactivation by (R,R)-delta-methyl-alpha-acetylenicputrescine and was much less sensitive than the wild type enzyme to alpha-monofluoromethyldehydromethylornithine, showing that the reactive species formed from these inhibitors either cannot be formed by this mutant or are unable to react with lysine 69.	Lysine	382-388	ornithine decarboxylase, structural 1	Mus musculus	55-58
8278631-7	1993	The major peak corresponded to a 22 amino acid peptide, which differed only from canine motilin at position 12, where Lys is replaced by Arg.	Lysine	118-121	motilin	Canis lupus familiaris	88-95
8218246-4	1993	The presence of a C-terminal Lys in many of the peptides that are restricted to IEk suggests that this electrostatic interaction is widely used to bind peptides to this MHC molecule.	Lysine	29-32	major histocompatibility complex, class I, C	Homo sapiens	169-172
8405666-8	1993	Furthermore, anti-MK antibody inhibited neurite extension not only on MK-coated dishes, but also on poly-L-lysine-coated dishes.	Lysine	100-113	midkine	Rattus norvegicus	18-20
8372437-3	1993	Analysis of in-frame deletion and substitution mutants revealed that amino acid substitution in a triple lysine motif (residues 214-216) completely abrogated nuclear localization of the 672 amino acid NS1 polypeptide.	Lysine	105-111	influenza virus NS1A binding protein	Homo sapiens	201-204
8349587-0	1993	Microheterogeneity around the reactive lysine residue in the myosin heavy chain from rabbit skeletal muscle.	Lysine	39-45	PBV1SPCR2	Oryctolagus cuniculus	61-79
8344413-4	1993	Cathepsin B prefers large hydrophobic residues in the P1" position of a substrate while cathepsin L has an opposite trend, favoring amino acids with small (Ala, Ser) or long but non-branched (Asn, Gln, Lys) side chains.	Lysine	202-205	cathepsin B	Homo sapiens	0-11
8407063-4	1993	Conversely, RUN-EXH was increased (p &lt; 0.05) by the greatest dosage of LY 53,857 (LY: 5-HT1C and 5-HT2 antagonist) (1.5 mg.kg-1 i.p.).	Lysine	74-76	5-hydroxytryptamine receptor 2C	Rattus norvegicus	89-95
8212054-3	1993	Amino acid analysis on the chemically modified yeast G6PD showed a formation of a lysine adduct which is probably linked to the inactivation.	Lysine	82-88	glucose-6-phosphate dehydrogenase	Homo sapiens	53-57
7688509-1	1993	An anti-peptide antibody was raised against the sequence Thr-Gly-Ala-Leu-Phe-Lys-His-Ser-Glu-Asn-Tyr-Lys which occurs at positions 283-294 in the rat cytochrome P450 enzyme CYP1A2.	Lysine	77-80	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179
7688509-1	1993	An anti-peptide antibody was raised against the sequence Thr-Gly-Ala-Leu-Phe-Lys-His-Ser-Glu-Asn-Tyr-Lys which occurs at positions 283-294 in the rat cytochrome P450 enzyme CYP1A2.	Lysine	101-104	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179
7903430-1	1993	This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E).	Lysine	73-76	proopiomelanocortin	Rattus norvegicus	38-58
7903430-1	1993	This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E).	Lysine	73-76	proopiomelanocortin	Rattus norvegicus	60-64
7903430-3	1993	These cells lines are known to process POMC differently at Lys-Arg residues, though less is known about their Lys-Lys cleavage.	Lysine	59-62	proopiomelanocortin	Rattus norvegicus	39-43
7916636-4	1993	The human kallikrein gene and urinary kallikrein both contain a Lys-162 instead of the reported Glu-162.	Lysine	64-67	kallikrein related peptidase 4	Homo sapiens	10-20
7916636-4	1993	The human kallikrein gene and urinary kallikrein both contain a Lys-162 instead of the reported Glu-162.	Lysine	64-67	kallikrein related peptidase 4	Homo sapiens	38-48
8515424-5	1993	The binding site is found in the C-terminal region of bv-PLA2, forming part of the proposed interfacial surface for binding to aggregated substrates, and comprises two distinct regions: (i) a hydrophobic cavity delimited by the C-terminal beta-sheet and the antiparallel beta-sheet, which interacts with the apolar zone of MLD, and (ii) a cationic site made up of residues Arg-58 and Lys-94, which interacts with the polar zone.	Lysine	384-387	phospholipase A2 group IIA	Homo sapiens	57-61
8515424-6	1993	Molecular dynamics and molecular orbital calculations indicate that the most likely initial reaction between MLD and bv-PLA2 is formation of a Schiff base between Lys-94 and the aldehyde generated upon opening of MLD"s gamma-lactone ring, supporting recent model reaction studies.	Lysine	163-166	phospholipase A2 group IIA	Homo sapiens	120-124
8373517-4	1993	Lysine residues are found in both these positions in hCG-beta.	Lysine	0-6	chorionic gonadotropin subunit beta 3	Homo sapiens	53-61
8373517-5	1993	Using site-directed mutagenesis, each of these two lysines in hCG-beta was replaced with glutamic acid.	Lysine	51-58	chorionic gonadotropin subunit beta 3	Homo sapiens	62-70
8359489-0	1993	GLUT 1: identification of exofacial lysine-residues.	Lysine	36-42	solute carrier family 2 member 1	Homo sapiens	0-6
8467951-2	1993	To investigate whether a direct protein-protein interaction between apoA-I and lecithin:cholesterol acyltransferase (LCAT) is necessary for the activation of the enzyme, apoA-I was labelled with N-methylisatoic anhydride at lysine residues.	Lysine	224-230	lecithin-cholesterol acyltransferase	Homo sapiens	79-115
8467951-2	1993	To investigate whether a direct protein-protein interaction between apoA-I and lecithin:cholesterol acyltransferase (LCAT) is necessary for the activation of the enzyme, apoA-I was labelled with N-methylisatoic anhydride at lysine residues.	Lysine	224-230	lecithin-cholesterol acyltransferase	Homo sapiens	117-121
8384830-6	1993	Comparison with sequences of other cytochromes c indicated the closest similarity to cytochrome c from snapping turtle (Chelydra serpentina) with substitutions at five positions corresponding to residues 32 (His--&gt;Asn), 44 (Glu--&gt;Pro), 89 (Ala--&gt;Pro), 100 (Asp--&gt;Glu), and 104 (Lys--&gt;Asn), respectively.	Lysine	290-293	cytochrome c	Alligator mississippiensis	85-97
8424775-1	1993	The dihydrolipoamide acetyltransferase subunit (E2p) of mammalian pyruvate dehydrogenase complex has two highly conserved lipoyl domains each modified with a lipoyl cofactor bound in amide linkage to a specific lysine residue.	Lysine	211-217	cystatin 12, pseudogene	Homo sapiens	48-51
7685968-5	1993	This inhibition was not observed with a mutant form of the kinase (Lys--&gt;Arg at position 296) and it was reversed by antisense expression of the p68 gene.	Lysine	67-70	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	148-151
1472536-6	1992	The addition of 1 microM-alpha 2-AP to this plasma prevented the formation of Lys-derivatives and produced a marked decrease (42%) in the number of plasminogen-binding sites.	Lysine	78-81	serpin family F member 2	Homo sapiens	25-35
1429654-1	1992	Conserved lysines of mouse ornithine decarboxylase were individually mutated to arginines.	Lysine	10-17	ornithine decarboxylase, structural 1	Mus musculus	27-50
1409574-10	1992	Our model of heparin bound to PF4 has the anionic polysaccharide perpendicular to the alpha-helices, wrapped about the tetramer along the ring of positive charge, and salt linked to all four lysines on the helix of each monomer.	Lysine	191-198	platelet factor 4	Bos taurus	30-33
1520883-3	1992	In all individuals, we found a single-base substitution in codon 56 of one band 3 allele changing lysine to glutamic acid (AAG----GAG) which, in some of them, was linked with an additional mutation in cdb3.	Lysine	98-104	N-methylpurine DNA glycosylase	Homo sapiens	123-126
1379587-10	1992	A lysine-lysine dipeptide bond is one likely processing site of pro-guanylin and would generate a 60-amino acid mature peptide.	Lysine	2-8	guanylate cyclase activator 2A	Rattus norvegicus	68-76
1379587-10	1992	A lysine-lysine dipeptide bond is one likely processing site of pro-guanylin and would generate a 60-amino acid mature peptide.	Lysine	9-15	guanylate cyclase activator 2A	Rattus norvegicus	68-76
1627652-3	1992	As in the human and porcine precursors, two lysine residues follow motilin in the rabbit sequence.	Lysine	44-50	motilin	Homo sapiens	67-74
1629226-2	1992	Carboxyl-terminal sequences Ser-Lys-Leu (SKL) and Leu-Gln-Ser-Lys-Leu (LQSKL) of acyl-CoA oxidase (AOX) directed to peroxisomes the fused proteins with import-incompetent forms of AOX and catalase that had been truncated, implying that the SKL tripeptide functions as a targeting signal.	Lysine	32-35	acyl-CoA oxidase 1	Homo sapiens	81-97
1384831-0	1992	Protective effect of MDP-Lys(L18), a synthetic derivative of muramyldipeptide, on murine cytomegalovirus infection.	Lysine	25-28	ribosomal protein L18	Mus musculus	29-32
1384831-2	1992	Mice treated with 800 micrograms of MDP-Lys(L18) on day 2 before the virus challenge survived systemic lethal infection.	Lysine	40-43	ribosomal protein L18	Mus musculus	44-47
1384831-3	1992	The protective effect of MDP-Lys(L18) was evidenced by an increase in plaque-forming units per LD50 and a decrease in virus titers in the target organs.	Lysine	29-32	immunoglobulin kappa variable 1-13	Homo sapiens	33-36
1384831-5	1992	The natural killer (NK) activity was augmented remarkably in the mice treated with MDP-Lys(L18) or its original component, muramyldipeptide (MDP).	Lysine	87-90	ribosomal protein L18	Mus musculus	91-94
1384831-8	1992	The MDP-Lys(L18)-induced resistance was not abrogated by the treatment with anti-asialo GM1 serum.	Lysine	8-11	immunoglobulin kappa variable 1-13	Homo sapiens	12-15
1384831-9	1992	The NK activity augmented by MDP-Lys(L18) may contribute to some part of the protective effect, though the augmentation of the NK activity alone did not correlate completely with the protective effect of MDP-Lys(L18).	Lysine	33-36	immunoglobulin kappa variable 1-13	Homo sapiens	37-40
1384831-11	1992	Therefore, another host-mediated factor(s) may also participate in the antiviral effect of MDP-Lys(L18).	Lysine	95-98	immunoglobulin kappa variable 1-13	Homo sapiens	99-102
1375964-0	1992	Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues.	Lysine	101-104	cholecystokinin A receptor	Homo sapiens	36-50
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-113	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	39-62
1313296-0	1992	Photoinduced electron transfer between cytochrome c peroxidase and horse cytochrome c labeled at specific lysines with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) The reactions of yeast cytochrome c peroxidase with horse cytochrome c derivatives labeled at specific lysine amino groups with (dicarboxybipyridine)(bisbipyridine)ruthenium(II) [Ru(II)] were studied by flash photolysis.	Lysine	106-112	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	39-62
1550361-0	1992	The role of cytochrome P450 lysine residues in the interaction between cytochrome P450IA1 and NADPH-cytochrome P450 reductase.	Lysine	28-34	cytochrome p450 oxidoreductase	Rattus norvegicus	94-125
1550361-3	1992	Modification of lysine residues in P450IA1 greatly inhibits the interaction of P450IA1 with NADPH-cytochrome P450 reductase.	Lysine	16-22	cytochrome p450 oxidoreductase	Rattus norvegicus	92-123
1348749-5	1992	Cathepsin B/L-like activity was determined with Bz-Val-Lys-Lys-Arg-AFC, elastase-like activity with MeOSuc-Ala-Ala-Pro-Val-AFC, tryptase-like activity with Z-Ala-Ala-Lys-AFC, trypsin-like activity with Z-Gly-Gly-Arg-AFC and dipeptidyl peptidase IV-like activity with Ala-Pro-AFC.	Lysine	59-62	cathepsin B	Homo sapiens	0-11
1554412-3	1992	The observed GAG----AAG transition in codon 63, which replaces glutamic acid with lysine, was the only detectable mutation in exon 1 and 2 hotspot regions of Ki-ras in this tumor.	Lysine	82-88	KRAS proto-oncogene, GTPase	Rattus norvegicus	158-164
1660723-1	1991	The double charge, aspartic acid to lysine, point mutations were constructed at positions 37, 79, and 217 on the surface of cytochrome c peroxidase, sites purported to be within or proximal to the recognition site for cytochrome c in an electron-transfer productive complex formed by the two proteins.	Lysine	36-42	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	124-147
1719231-9	1991	Amino acid residues of ICAM-1 showing the greatest effect on virus and antibody binding included Pro-28, Lys-29, Leu-30, Leu-37, Lys-40, Ser-67, and Pro-70.	Lysine	105-108	intercellular adhesion molecule 1	Homo sapiens	23-29
1719231-9	1991	Amino acid residues of ICAM-1 showing the greatest effect on virus and antibody binding included Pro-28, Lys-29, Leu-30, Leu-37, Lys-40, Ser-67, and Pro-70.	Lysine	129-132	intercellular adhesion molecule 1	Homo sapiens	23-29
1939207-10	1991	When activated by trypsin, it hydrolyzes carboxypeptidase B substrates, hippuryl-Arg and hippuryl-Lys, but not carboxypeptidase A substrates, and it is inhibited by the specific carboxypeptidase B inhibitor (DL-5-guanidinoethyl)mercaptosuccinic acid.	Lysine	97-101	carboxypeptidase B1	Homo sapiens	41-59
1939207-10	1991	When activated by trypsin, it hydrolyzes carboxypeptidase B substrates, hippuryl-Arg and hippuryl-Lys, but not carboxypeptidase A substrates, and it is inhibited by the specific carboxypeptidase B inhibitor (DL-5-guanidinoethyl)mercaptosuccinic acid.	Lysine	97-101	carboxypeptidase B1	Homo sapiens	178-196
1932747-6	1991	Lysine analogues and active or diisopropylfluorophosphate-inactivated u-PA inhibited t-PA binding to monocytes, monocytoid cells, and endothelial cells with similar IC50 (concentration producing 50% inhibition) values, suggesting that the same recognition specificity mediates t-PA binding to all of these cell types.	Lysine	0-6	chromosome 20 open reading frame 181	Homo sapiens	85-89
1811167-6	1991	Culture-derived radioactive soluble elastin was added to the "substrate" cultures and the presence of radioactivity in the insoluble elastin as well as in the lysine-derived crosslinks unique to elastin (desmosines) was measured.	Lysine	159-165	elastin	Rattus norvegicus	36-43
1811167-8	1991	After an initial 4-hour incubation of the cells with [3H]-lysine-labelled soluble elastin, most of the radioactivity in the insoluble elastin was associated with the lysine and only a negligible amount was detected in the desmosines.	Lysine	58-64	elastin	Rattus norvegicus	82-89
1811167-8	1991	After an initial 4-hour incubation of the cells with [3H]-lysine-labelled soluble elastin, most of the radioactivity in the insoluble elastin was associated with the lysine and only a negligible amount was detected in the desmosines.	Lysine	58-64	elastin	Rattus norvegicus	134-141
1811167-8	1991	After an initial 4-hour incubation of the cells with [3H]-lysine-labelled soluble elastin, most of the radioactivity in the insoluble elastin was associated with the lysine and only a negligible amount was detected in the desmosines.	Lysine	166-172	elastin	Rattus norvegicus	134-141
1776140-7	1991	Removal of the C-terminal lysine of Lys-UK by CpB produced small but significant increases in the Michaelis constants for the activation of both Glu- and Lys-plasminogen.	Lysine	26-32	carboxypeptidase B1	Homo sapiens	46-49
1776140-7	1991	Removal of the C-terminal lysine of Lys-UK by CpB produced small but significant increases in the Michaelis constants for the activation of both Glu- and Lys-plasminogen.	Lysine	36-39	carboxypeptidase B1	Homo sapiens	46-49
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Lysine	215-218	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Lysine	215-218	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
2068071-9	1991	The variant COOH terminus ends with the dibasic sequence Arg-Lys that is apparently removed through stepwise cleavage by serum carboxypeptidase B to yield several forms of circulating albumin.	Lysine	61-64	carboxypeptidase B1	Homo sapiens	127-145
1892395-2	1991	For secretion by yeast cells of HGH with the same NH2 terminus as native HGH, an artificial Lys-Arg linker, which is one of the potential KEX2 recognition sequences, was introduced at the junction between the M. pusillus rennin secretion leader and mature HGH.	Lysine	92-95	kexin KEX2	Saccharomyces cerevisiae S288C	138-142
1892395-5	1991	These results clearly showed that the leader peptide with the Lys-Arg linker was recognized and specifically cleaved by the yeast KEX2 protease.	Lysine	62-65	kexin KEX2	Saccharomyces cerevisiae S288C	130-134
2019594-7	1991	The lower molecular weight variant of p14 lacks Cys-3 (Met-Thr-Cys-Lys-Met...) suggesting that differing translational start sites account for these two forms of p14.	Lysine	67-70	ribonuclease P/MRP subunit p14	Homo sapiens	38-41
1847072-4	1991	One of the peptides, representing the carboxy-terminal 19 amino acids of alpha 2-antiplasmin, was approximately 5-fold more effective than others with carboxy-terminal lysines.	Lysine	168-175	serpin family F member 2	Homo sapiens	73-92
1899057-3	1991	The in vitro product, AFG1-lysine, was characterized by UV, fluorescence, 1H- and 13C-NMR spectroscopy and fast atom bombardment MS. A competitive enzyme-linked immunoassay for this adduct was established using polyclonal antibodies to AFB1 and this was used together with an HPLC-fluorescence technique to quantitate the in vivo formation of AFG1-albumin adducts in comparison to AFB1.	Lysine	27-33	AFG1 like ATPase	Homo sapiens	22-26
1899057-3	1991	The in vitro product, AFG1-lysine, was characterized by UV, fluorescence, 1H- and 13C-NMR spectroscopy and fast atom bombardment MS. A competitive enzyme-linked immunoassay for this adduct was established using polyclonal antibodies to AFB1 and this was used together with an HPLC-fluorescence technique to quantitate the in vivo formation of AFG1-albumin adducts in comparison to AFB1.	Lysine	27-33	AFG1 like ATPase	Homo sapiens	343-347
20504692-4	1991	Binding involves a tripeptide sequence consisting of aryl, nonpolar and positively charged moieties in residues 7-9 (Phe-Trp-Lys) of the receptor binding site of somatostatin and residues 15-17 (Tyr-Pro-Arg) of GRP, a region distinct from its biologically active carboxyl-terminus.	Lysine	125-128	somatostatin	Homo sapiens	162-174
1896431-5	1991	The significance of some changes in the catalytic site is uncertain due to the intrusion of a symmetry related Lys-70 side chain which hydrogen bonds to both Asp-21 and Glu-43.	Lysine	111-114	beta-secretase 2	Homo sapiens	158-164
2238469-6	1990	Unlike any other HAs of influenza viruses, the H14 HAs contained lysine at the cleavage site between HA1 and HA2 instead of arginine.	Lysine	65-71	H1.4 linker histone, cluster member	Homo sapiens	47-50
2267133-4	1990	Bone marrow DNA from both patients had identical missense mutations of N-ras codon 61 changing CAA to AAA, resulting in a substitution of lysine for glutamine in the encoded protein.	Lysine	138-144	NRAS proto-oncogene, GTPase	Homo sapiens	71-76
2211639-1	1990	Four forms of dihydrodipicolinate synthase (DHDPS), which catalyzes the first reaction in the lysine-specific biosynthetic pathway in higher plants, were purified to homogeneity from a suspension culture of wheat (Triticum aestivum).	Lysine	94-100	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	14-42
2211639-1	1990	Four forms of dihydrodipicolinate synthase (DHDPS), which catalyzes the first reaction in the lysine-specific biosynthetic pathway in higher plants, were purified to homogeneity from a suspension culture of wheat (Triticum aestivum).	Lysine	94-100	4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic	Triticum aestivum	44-49
24197186-3	1990	Since poly-L-lysine was found to stabilize MTs in protoplasts, we examined extensin, an important polycationic component of the cell wall, and found it also to be effective in stabilizing the MTs of protoplasts.	Lysine	6-19	extensin	Nicotiana tabacum	75-83
2120170-12	1990	For starter pigs, ADG and gain/feed were optimized at 1.1 to 1.2% total lysine.	Lysine	72-78	ADG	Sus scrofa	18-21
2120170-13	1990	For grower pigs, ADG and gain/feed were optimized at .86% total lysine.	Lysine	64-70	ADG	Sus scrofa	17-20
2168484-6	1990	Adding a lysine or arginine onto the spermine moiety increased the compound"s potency on the nACh-R with little effect on the NMDA-R. Because spermine is a component of PhTX, the effects of five polyamines were also studied.	Lysine	9-15	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	93-99
2116982-3	1990	Sequencing of the amino terminus of an A-like form of enzyme secreted by a kex2 mutant indicated the presence of 4 amino acids, with a pair of basic residues (Lys-Arg) at their carboxyl side, preceding the amino terminus of the wild-type external exoglucanase.	Lysine	159-162	kexin KEX2	Saccharomyces cerevisiae S288C	75-79
1973167-4	1990	Using molecular techniques, two point mutations were detected in the coding sequence of the FX Vorarlberg gene: a G----A at base pair 160 in exon II resulting in a change of Gla14 (GAA) to Lys (AAA); a G----A at base pair 424 in exon V resulting in a change from Glu102 (GAG) to Lys (AAG).	Lysine	189-192	N-methylpurine DNA glycosylase	Homo sapiens	284-287
2376470-1	1990	Cyclic CCK analogues in which positions 28 and 31 have been replaced by lysine residues and whose side chains are bridged by a succinic moiety, were synthesized.	Lysine	72-78	cholecystokinin	Rattus norvegicus	7-10
2108319-1	1990	A cell line was generated from U7 cells (a subline of PC12 rat pheochromocytoma cells) that contains a stably integrated transforming mouse N-ras (Lys-61) gene under the control of the long terminal repeat from mouse mammary tumor virus.	Lysine	147-150	neuroblastoma ras oncogene	Mus musculus	140-145
2105951-5	1990	The aldose reductase was shown to contain no carbohydrate despite the fact that the enzyme contains the consensus sequence -Asn-Lys-Thr- for N-linked glycosylation.	Lysine	128-131	aldose reductase	Bos taurus	4-20
1968467-4	1990	Superactive octapeptide analogs of somatostatin-containing hexapeptide sequences Cys-Phe-D-Trp-Lys-Thr-Cys or Cys-Tyr-D-Trp-Lys-Val-Cys showed significant binding affinities to SS-14 receptors.	Lysine	95-98	somatostatin	Homo sapiens	35-47
1689763-2	1990	With truncated recombinant fusion proteins and synthetic peptides, a subset of anti-p68 autoantibodies was found to recognize the amino acid sequence motif Glu-Arg-Lys-Arg-Arg (ERKRR).	Lysine	164-167	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	84-87
1688946-9	1990	4-Amino-4-deoxy-N10-methylpteroylglutamyl-gamma-glutamylpoly (L-lysine) conjugate [MTX(G2)-poly-L-Lys-52000] and MTX(G4)-poly-L-Lys-52000 were among the most active (I50 = 8.0 and 10 nM against H35 cells) MTX-polylysines synthesized to date, and they were somewhat more inhibitory to the transport resistant cells.	Lysine	62-70	G4 protein	Rattus norvegicus	113-119
2104892-7	1990	Lytically active LAK effector subsets were either CD8+ B220+ Ly-24+ or NK1.1+ B220+ Ly-24+.	Lysine	0-2	CD8a molecule	Homo sapiens	50-53
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	48-50	CD8a molecule	Homo sapiens	133-136
2104892-12	1990	YAC-1 was lysed exclusively by the NK1.1+ B220+ Ly-24+ subset, 2,4,6-trinitrobenzene sulfonic acid-self was lysed exclusively by the CD8+ B220+ Ly-24+ subset whereas CL27A was lysed by both subsets.	Lysine	144-146	CD8a molecule	Homo sapiens	133-136
2153283-2	1990	We have transfected such cells with cDNA for the PDGF B-type receptor, both the wild-type receptor and a mutant form of the receptor (K634A), in which the putative nucleotide-binding lysine of the protein-tyrosine domain has been changed to alanine.	Lysine	183-189	platelet derived growth factor subunit B	Homo sapiens	49-55
3096340-1	1986	A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized.	Lysine	75-78	Harvey rat sarcoma virus oncogene	Mus musculus	92-98
33232890-2	2021	PRC2 comprises a trimeric core of SUZ12, EED and EZH1/2, which together with RBBP4/7 is sufficient to catalyse mono-methylation, di-methylation and tri-methylation of histone H3 at lysine 27 (H3K27me1/2/3).	Lysine	181-187	embryonic ectoderm development	Homo sapiens	41-44
33801331-3	2021	In vitro, histone H2B monoubiquitination at lysine 120 (H2Bub1) impairs chromatin compaction, while in vivo H2Bub1 is rapidly depleted from chromatin upon entry into mitosis, suggesting that H2Bub1 removal may be a pre-requisite for mitotic fidelity.	Lysine	44-50	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	58-62
33588715-5	2021	PSAT1 exists as a functional dimer, where each protomer has a large and a small domain; each large domain contains a Lys residue that covalently binds PLP.	Lysine	117-120	proteolipid protein 1	Homo sapiens	151-154
17433364-8	2007	Despite great sequence similarity between the human CHD1 and CHD2 chromodomains, variation within an insert likely prevents CHD2 double chromodomains from binding lysine 4-methylated histone H3 tail as efficiently as in CHD1.	Lysine	163-169	chromodomain helicase DNA binding protein 2	Homo sapiens	61-65
17433364-8	2007	Despite great sequence similarity between the human CHD1 and CHD2 chromodomains, variation within an insert likely prevents CHD2 double chromodomains from binding lysine 4-methylated histone H3 tail as efficiently as in CHD1.	Lysine	163-169	chromodomain helicase DNA binding protein 2	Homo sapiens	124-128
34871563-1	2022	The lysyl oxidase (LOX) family of enzymes catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-linkages, an essential process for extracellular matrix (ECM) maturation.	Lysine	80-86	lysyl oxidase	Homo sapiens	4-17
34871563-1	2022	The lysyl oxidase (LOX) family of enzymes catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-linkages, an essential process for extracellular matrix (ECM) maturation.	Lysine	80-86	lysyl oxidase	Homo sapiens	19-22
34826399-5	2022	Chromatin immunoprecipitation analysis revealed that lysine demethylase 3A (KDM3A) expression was transcriptionally activated by HIF-3alpha under hypoxia, and KDM3A occupied the SRY-box transcription factor 9 (SOX9) gene promoter region through H3 lysine 9 dimethylation (H3K9me2).	Lysine	248-254	lysine demethylase 3A	Homo sapiens	53-74
34826399-5	2022	Chromatin immunoprecipitation analysis revealed that lysine demethylase 3A (KDM3A) expression was transcriptionally activated by HIF-3alpha under hypoxia, and KDM3A occupied the SRY-box transcription factor 9 (SOX9) gene promoter region through H3 lysine 9 dimethylation (H3K9me2).	Lysine	248-254	lysine demethylase 3A	Homo sapiens	159-164
34954891-4	2022	The Euchromatin Histone Lysine Methyltransferase 1 (EHMT1) and Euchromatin Histone Lysine Methyltransferase 2 (EHMT2) that primarily mediate histone 3 lysine 9 di-methylation (H3K9me2), as well as methylation of non-histone proteins, are now recognized to be aberrantly expressed in many cancers.	Lysine	151-157	euchromatic histone lysine methyltransferase 2	Homo sapiens	111-116
34877957-4	2021	This work demonstrates that histone lysine methyltransferases G9a and GLP do catalyse methylation of the most similar lysine mimic, whereas they typically do not tolerate more sterically demanding side chains.	Lysine	118-124	euchromatic histone lysine methyltransferase 2	Homo sapiens	62-65
34877957-5	2021	In contrast, histone lysine acetyltransferases GCN5 and PCAF do not catalyse acetylation of the same panel of lysine analogues.	Lysine	21-27	lysine acetyltransferase 2A	Homo sapiens	47-51
34984308-9	2021	Further, lysine acetylation sites and HDAC enzyme prediction revealed the involvement of 15 and 27 potential lysine residues of CREB1 and HINFP, respectively.	Lysine	9-15	cAMP responsive element binding protein 1	Homo sapiens	128-133
34984308-9	2021	Further, lysine acetylation sites and HDAC enzyme prediction revealed the involvement of 15 and 27 potential lysine residues of CREB1 and HINFP, respectively.	Lysine	109-115	cAMP responsive element binding protein 1	Homo sapiens	128-133
34914972-11	2022	These observations show for the first time that IP-10 mRNA stability is dynamically regulated by Lysine demethylation of hnRNPK by LSD-1.	Lysine	97-103	C-X-C motif chemokine ligand 10	Homo sapiens	48-53
34914972-11	2022	These observations show for the first time that IP-10 mRNA stability is dynamically regulated by Lysine demethylation of hnRNPK by LSD-1.	Lysine	97-103	lysine demethylase 1A	Homo sapiens	131-136
34806925-8	2021	Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells.	Lysine	142-148	small nucleolar RNA host gene 1	Homo sapiens	17-22
34851506-0	2022	Ezh2 promotes TRbeta lysine methylation-mediated degradation in hepatocellular carcinoma.	Lysine	21-27	T cell receptor alpha locus	Homo sapiens	14-20
34851506-5	2022	METHODS: Based on a previous study, we predicted that the lysine methyltransferase and methylation sites of TRbeta by comparing the amino acid sequences of histone H3 and TRbeta.	Lysine	58-64	T cell receptor alpha locus	Homo sapiens	108-114
34851506-5	2022	METHODS: Based on a previous study, we predicted that the lysine methyltransferase and methylation sites of TRbeta by comparing the amino acid sequences of histone H3 and TRbeta.	Lysine	58-64	T cell receptor alpha locus	Homo sapiens	171-177
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	T cell receptor alpha locus	Homo sapiens	124-130
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	T cell receptor alpha locus	Homo sapiens	225-231
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	87-93	T cell receptor alpha locus	Homo sapiens	284-290
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	T cell receptor alpha locus	Homo sapiens	124-130
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	T cell receptor alpha locus	Homo sapiens	225-231
34851506-11	2022	RESULTS: The presence of enhancer of zeste homolog 2 (Ezh2), a methyltransferase of H3 lysine 27, as a methyltransferase of TRbeta also revealed that direct lysine methylation and consequent stimulated protein degradation of TRbeta underlies the negative correlation between Ezh2 and TRbeta.	Lysine	157-163	T cell receptor alpha locus	Homo sapiens	284-290
34228315-8	2021	Finally, we showed that SRC3 regulated synaptic plasticity and learning mainly dependent on its lysine acetyltransferase activity.	Lysine	96-102	nuclear receptor coactivator 3	Mus musculus	24-28
34832496-4	2021	We prepared nanoballs (BMP4-nanoballs) constructed with pBMP4 and dendrigraft poly-L-lysine (DGL, a cationic polymer) coated by gamma-polyglutamic acid (gamma-PGA; an anionic polymer), and determined their biological functions in vitro and in vivo.	Lysine	78-91	bone morphogenetic protein 4	Rattus norvegicus	23-27
34798872-8	2021	Mechanistically, Cb1 enhanced JAK2 ubiquitination and decreased JAK2 and STAT4 expression, where STAT4 improved Runx3 expression by regulating histone H3 lysine 4 trimethylation level.	Lysine	154-160	cannabinoid receptor 1	Rattus norvegicus	17-20
34830172-8	2021	This toxin is the alpha-KTx 15.1, which occludes the Kv3.1 channel pore by means of the lysine 27 lateral chain.	Lysine	88-94	potassium voltage-gated channel subfamily C member 1	Homo sapiens	53-58
34795530-15	2021	Mechanically, KAT7 was able to bind to PD-L1 promoter and epigenetically induce PD-L1 expression by promoting the enrichment of histone H3 lysine 14 acetylation (H3K14ac) and RNA polymerase II on PD-L1 promoter.	Lysine	139-145	K(lysine) acetyltransferase 7	Mus musculus	14-18
34746682-0	2021	Changes in Histone H3 Acetylation on Lysine 9 Accompany Abeta 1-40 Overexpression in an Alzheimer"s Disease Yeast Model.	Lysine	37-43	histone H3	Saccharomyces cerevisiae S288C	11-21
34746682-6	2021	We find a modest decrease in the acetylation levels on lysine 9 of histone H3 in the context of Abeta 1-40 overexpression.	Lysine	55-61	histone H3	Saccharomyces cerevisiae S288C	67-77
34416463-2	2021	RNF128 is an E3 ubiquitin ligase that can modulate the activity of target protein via ubiquitination of specific lysine residues.	Lysine	113-119	ring finger protein 128	Homo sapiens	0-6
34771652-0	2021	Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis.	Lysine	11-17	nuclear receptor subfamily 1 group I member 3	Homo sapiens	57-60
34705884-4	2021	The modified nucleotide cAMP accumulates in the absence of glucose and binds to the CRP protein, but its ability to bind to DNA can be impaired by lysine-acetylation of CRP.	Lysine	147-153	catabolite gene activator protein	Escherichia coli	169-172
34705884-8	2021	During the growth in minimal media supplemented with glycerol, ppGpp promotes the acetylation of CRP by the Nepsilon-lysine acetyltransferases YfiQ.	Lysine	117-123	catabolite gene activator protein	Escherichia coli	97-100
34685453-0	2021	Structure, Activity, and Function of the Protein Lysine Methyltransferase G9a.	Lysine	49-55	euchromatic histone lysine methyltransferase 2	Homo sapiens	74-77
34216690-6	2021	Activated PKA upregulates the expression of NF-kappaB subunit c-Rel (REL) and acetylates histone H3 at lysine 9 (H3K9ac) to promote the transcription of SNAIL and SLUG.	Lysine	103-109	snail family transcriptional repressor 2	Homo sapiens	163-167
34224844-7	2021	To determine the mechanism of deptor suppression, we found that high glucose significantly increased the expression of EZH2, resulting in lysine-27 tri-methylation of histone H3 (H3K27Me3).	Lysine	138-144	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	119-123
34364980-8	2021	Proteomics demonstrated the presence of MDA adducts on Lysine residues of HDL proteins, mainly ApoA-I.	Lysine	55-61	apolipoprotein A-I	Mus musculus	95-101
34599168-3	2021	SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127.	Lysine	75-81	speckle type BTB/POZ protein	Homo sapiens	0-4
34584221-8	2022	Mechanistically, TRIM31 interacted with and catalyzed the K48-linked polyubiquitination of lysine 72 on Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), followed by the proteasomal degradation of MAP3K7, which further negatively regulated TGF-beta1-mediated Smad and MAPK/NF-kappaB signaling pathways.	Lysine	91-97	tripartite motif-containing 31	Mus musculus	17-23
34515265-8	2021	Our results also revealed an important role of the lysine residues of P62 in the binding process by forming initial contacts with aspartic acids on the fibril surface.	Lysine	51-57	nucleoporin 62	Homo sapiens	70-73
34621741-2	2021	ATM activation is complex, and primarily mediated by the lysine acetyltransferase Tip60.	Lysine	57-63	lysine acetyltransferase 5	Homo sapiens	82-87
34621741-3	2021	Epigenetic changes can regulate this Tip60-dependent activation of ATM, requiring the interaction of Tip60 with tri-methylated histone 3 lysine 9 (H3K9me3).	Lysine	137-143	lysine acetyltransferase 5	Homo sapiens	37-42
34621741-3	2021	Epigenetic changes can regulate this Tip60-dependent activation of ATM, requiring the interaction of Tip60 with tri-methylated histone 3 lysine 9 (H3K9me3).	Lysine	137-143	lysine acetyltransferase 5	Homo sapiens	101-106
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	Xbp1p	Saccharomyces cerevisiae S288C	191-195
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	GTPase-activating protein BUD2	Saccharomyces cerevisiae S288C	217-221
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	Spc42p	Saccharomyces cerevisiae S288C	253-258
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Lysine	60-66	Sli15p	Saccharomyces cerevisiae S288C	268-273
34339735-4	2021	To investigate whether acetylation of non-histone proteins is important for synaptic plasticity, we analyzed mouse brain acetylome and found that calmodulin (CaM), a ubiquitous Ca2+ sensor, was acetylated on three lysine residues which were conserved across species.	Lysine	214-220	calmodulin 2	Mus musculus	146-156
34339735-4	2021	To investigate whether acetylation of non-histone proteins is important for synaptic plasticity, we analyzed mouse brain acetylome and found that calmodulin (CaM), a ubiquitous Ca2+ sensor, was acetylated on three lysine residues which were conserved across species.	Lysine	214-220	calmodulin 2	Mus musculus	158-161
34497368-0	2021	TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.	Lysine	44-50	CYLD lysine 63 deubiquitinase	Homo sapiens	11-15
34497368-5	2021	TRIM15 and CYLD regulate ERK ubiquitination at defined lysine residues through mutually exclusive interactions as well as opposing activities.	Lysine	55-61	CYLD lysine 63 deubiquitinase	Homo sapiens	11-15
34144503-1	2021	Enhancer of zeste homolog 2 (EZH2) is the catalytic core of polycomb repressive complex 2 (PRC2), which primarily methylates lysine 27 on histone H3 (H2K27me3), generating transcriptionally suppressed heterochromatin.	Lysine	125-131	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-27
34144503-1	2021	Enhancer of zeste homolog 2 (EZH2) is the catalytic core of polycomb repressive complex 2 (PRC2), which primarily methylates lysine 27 on histone H3 (H2K27me3), generating transcriptionally suppressed heterochromatin.	Lysine	125-131	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	29-33
34111434-7	2021	In a term of mechanism, BAG3 epigenetically regulated GALNT10 transactivation via histone H3 lysine 4 (H3K4) presenter WDR5.	Lysine	93-99	polypeptide N-acetylgalactosaminyltransferase 10	Homo sapiens	54-61
34224729-4	2021	Next, we detail the reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) enzymes that are known to control histone lysine methylation in budding yeast cells.	Lysine	208-214	histone methyltransferase SET2	Saccharomyces cerevisiae S288C	92-97
34168040-1	2021	G9a is a histone methyltransferase responsible for the dimethylation of histone H3 at lysine 9 (H3K9me2).	Lysine	86-92	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
34220184-10	2021	We identified that EPHA2 rs137853199 is degraded via the ubiquitin-proteasomal pathway through a lysine-48 (K48) residue linkage.	Lysine	97-103	EPH receptor A2	Homo sapiens	19-24
34137174-4	2021	At the centre of the pathway is the mono-ubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues.	Lysine	110-116	FA complementation group D2	Homo sapiens	76-82
34249418-0	2021	Induction of epithelial-mesenchymal transition (EMT) by hypoxia-induced lncRNA RP11-367G18.1 through regulating the histone 4 lysine 16 acetylation (H4K16Ac) mark.	Lysine	126-132	pre-mRNA processing factor 31	Homo sapiens	79-83
34249418-8	2021	LncRNA RP11-367G18.1 specifically regulates the histone 4 lysine 16 acetylation (H4K16Ac) mark that is located on the promoters of two "core" EMT regulators, Twist1 and SLUG, and VEGF genes.	Lysine	58-64	pre-mRNA processing factor 31	Homo sapiens	7-11
34249418-8	2021	LncRNA RP11-367G18.1 specifically regulates the histone 4 lysine 16 acetylation (H4K16Ac) mark that is located on the promoters of two "core" EMT regulators, Twist1 and SLUG, and VEGF genes.	Lysine	58-64	snail family transcriptional repressor 2	Homo sapiens	169-173
34140780-0	2021	G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.	Lysine	62-68	euchromatic histone lysine methyltransferase 2	Homo sapiens	0-3
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	lysine demethylase 3A	Homo sapiens	67-73
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Lysine	46-52	lysine demethylase 6B	Homo sapiens	95-100
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	4-10	lysine demethylase 2A	Homo sapiens	23-28
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	4-10	lysine demethylase 2A	Homo sapiens	44-50
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	4-10	lysine demethylase 2A	Homo sapiens	54-60
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	4-10	keratin 36	Homo sapiens	96-99
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	89-95	lysine demethylase 2A	Homo sapiens	23-28
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	89-95	lysine demethylase 2A	Homo sapiens	44-50
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	89-95	lysine demethylase 2A	Homo sapiens	54-60
34079757-1	2021	The lysine demethylase KDM2A (also known as JHDM1A or FBXL11) demethylates histone H3 at lysine K36 which lead to epigenetic regulation of cell proliferation and tumorigenesis.	Lysine	89-95	keratin 36	Homo sapiens	96-99
34696686-5	2021	In the current study we identified, histone H3-lysine 27 trimethylation (H3K27me3)-specific demethylase, KDM6B to be upregulated in both cell culture and in murine model of Salmonella infection.	Lysine	47-53	KDM1 lysine (K)-specific demethylase 6B	Mus musculus	105-110
35551004-0	2022	New insight into the molecular mechanism of protein cross-linking induced by cis-2-butene-1,4-dial, the metabolite of furan: Formation of 2-substituted pyrrole cross-links involving the cysteine and lysine residues.	Lysine	199-205	suppressor of cytokine signaling 2	Homo sapiens	77-82
35395178-5	2022	In addition, GSK3735967 introduces two new binding sites, where it interacts with and stabilizes the displaced DNMT1 active-site loop and it occupies an open aromatic cage in which trimethylated histone H4 lysine 20 is expected to bind.	Lysine	206-212	DNA methyltransferase 1	Homo sapiens	111-116
35411950-8	2022	Mechanistically, USP7 inhibition greatly reduces the methylation of histone 3 on lysine 4 (H3K4me2), which is an epigenetic marker for active enhancers.	Lysine	81-87	ubiquitin specific peptidase 7	Homo sapiens	17-21
35608294-0	2022	Fine tuning Acetyl-CoA Carboxylase 1 activity through localization: Functional genomics reveal a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.	Lysine	110-116	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	12-36
35608294-0	2022	Fine tuning Acetyl-CoA Carboxylase 1 activity through localization: Functional genomics reveal a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.	Lysine	110-116	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	182-186
35608294-3	2022	We have shown that Acc1 activity is reduced in the absence of the lysine acetyltransferase NuA4 in Saccharomyces cerevisiae.	Lysine	66-72	acetyl-CoA carboxylase ACC1	Saccharomyces cerevisiae S288C	19-23
35446024-6	2022	PEGylation of the MMP-targeting N-terminal domain of TIMP2 (N-TIMP2), via either cysteine or lysine residues, resulted in a significant decrease in N-TIMP2 affinity toward MMP-14 or multisite conjugation and conjugate heterogeneity, respectively.	Lysine	93-99	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	172-178
35581285-10	2022	But, the HP group resulted in increased (P < 0.05) levels of blood glucose, NEFA, and AAs (lysine and glutamic acid) compared to LP and MP groups under severe HS stress.	Lysine	91-97	haptoglobin	Bos taurus	9-11
35500243-1	2022	EZH2 inhibitors that prevent trimethylation of histone lysine 27 (H3K27) are often limited to the treatment of a subset of hematological malignancies.	Lysine	55-61	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
35538051-6	2022	Mass spectrometry identifies this protein as fatty acid synthase (FAS), which is modified on active site residues and, importantly, on non-lysine side-chains.	Lysine	139-145	fatty acid synthase	Homo sapiens	45-64
35538051-6	2022	Mass spectrometry identifies this protein as fatty acid synthase (FAS), which is modified on active site residues and, importantly, on non-lysine side-chains.	Lysine	139-145	fatty acid synthase	Homo sapiens	66-69
35504875-6	2022	In addition, chromatin immunoprecipitation, RNA-binding protein immunoprecipitation, and RNA pull-down assays predicted and validated that LINC00478 targeted lysine-specific demethylase-1 (KDM1A) and down-regulated the expression of MMP9 by decreasing the monomethylation on lysine 4 of histone H3 (H3K4me1) of MMP9 promoter.	Lysine	275-281	lysine demethylase 1A	Homo sapiens	189-194
35563478-2	2022	All participate in the biosynthesis of and maturation of connective tissues by catalyzing the oxidative deamination of lysine residues in collagens and elastin, which ultimately results in the development of cross-links required to function.	Lysine	119-125	elastin	Homo sapiens	152-159
34988909-8	2022	Ubiquitination of histone H2B at lysine residue 120 (H2BK120ub) at relapse was significantly decreased at the protein level, indicating that PHF6 loss might downregulate a TNF-alpha signaling pathway by reduction of H2BK120ub.	Lysine	33-39	H2B clustered histone 12	Homo sapiens	53-57
34988909-8	2022	Ubiquitination of histone H2B at lysine residue 120 (H2BK120ub) at relapse was significantly decreased at the protein level, indicating that PHF6 loss might downregulate a TNF-alpha signaling pathway by reduction of H2BK120ub.	Lysine	33-39	PHD finger protein 6	Homo sapiens	141-145
35490166-2	2022	General control nonrepressed protein 5 (GCN5)/lysine acetyltransferase 2 A, a member of the histone acetyltransferase and lysine acetyltransferase families, regulates a variety of physiological and pathological events.	Lysine	122-128	K(lysine) acetyltransferase 2A	Mus musculus	40-44
35490166-2	2022	General control nonrepressed protein 5 (GCN5)/lysine acetyltransferase 2 A, a member of the histone acetyltransferase and lysine acetyltransferase families, regulates a variety of physiological and pathological events.	Lysine	122-128	K(lysine) acetyltransferase 2A	Mus musculus	46-74
35484101-6	2022	BAP18 was recruited to histone H3 trimethylation at lysine 4 (H3K4me3)-marked promoter of S100A9 and enhanced its promoter activities.	Lysine	52-58	RIKEN cDNA 0610010K14 gene	Mus musculus	0-5
35484101-6	2022	BAP18 was recruited to histone H3 trimethylation at lysine 4 (H3K4me3)-marked promoter of S100A9 and enhanced its promoter activities.	Lysine	52-58	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	90-96
35343783-9	2022	Combining these changes resulted in two lysine-rich HIV-1AD8 Env variants (E.2 and AE.2) with neutralization- and cold-resistant phenotypes comparable to those of natural, less triggerable tier 2/3 HIV-1 isolates.	Lysine	40-46	endogenous retrovirus group K member 20	Homo sapiens	61-64
35234248-9	2022	A Lys-less nonubiquitinated phyllogen mutant induced degradation of MTF or a Lys-less mutant of MTF.	Lysine	2-5	metallothionein 1L, pseudogene	Homo sapiens	68-71
35234248-9	2022	A Lys-less nonubiquitinated phyllogen mutant induced degradation of MTF or a Lys-less mutant of MTF.	Lysine	2-5	metallothionein 1L, pseudogene	Homo sapiens	96-99
35234248-9	2022	A Lys-less nonubiquitinated phyllogen mutant induced degradation of MTF or a Lys-less mutant of MTF.	Lysine	77-80	metallothionein 1L, pseudogene	Homo sapiens	96-99
35471580-9	2022	Both ligases incorporated D,L-DAP in almost complete preference to L-Lys, consistent with the mass spectrophotometric data, with catalytic efficiencies similar to previously documented Gram negative bacterial MurE ligases.	Lysine	67-72	MurE	Physcomitrella patens	209-213
35509266-2	2022	This research aims to analyze the role of histone demethylase Lysine-specific demethylase 5A (KDM5A) in human periodontal ligament stem cells (hPDLSCs) with periodontitis.	Lysine	62-68	lysine demethylase 5A	Homo sapiens	94-99
35445296-0	2022	Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.	Lysine	26-32	SET domain containing 1B	Mus musculus	52-58
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Lysine	59-62	glycine amidinotransferase	Homo sapiens	66-101
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Lysine	59-62	glycine amidinotransferase	Homo sapiens	103-107
35352207-4	2022	In vitro, recombinant human arginase and bovine liver arginase I hydrolyzed hArg to Lys, suggesting Lys as a metabolite of hArg.	Lysine	84-87	arginase 1	Bos taurus	54-64
35352207-4	2022	In vitro, recombinant human arginase and bovine liver arginase I hydrolyzed hArg to Lys, suggesting Lys as a metabolite of hArg.	Lysine	100-103	arginase 1	Bos taurus	54-64
35349697-6	2022	Here, we elucidate that SIRT4 deacetylates the conserved lysine residue at 50 (K50) in MTHFD2.	Lysine	57-63	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	87-93
35332266-8	2022	We confirmed that KAT6A acetylates lysine 23 of histone H3 (H3K23), and then enhances the association of the nuclear receptor binding protein TRIM24 and H3K23ac.	Lysine	35-41	tripartite motif containing 24	Homo sapiens	142-148
35332362-5	2022	Association analysis was performed using a linear mixed model in R. In purebred Butana cattle, the lysine DGAT1 protein variant K232, which is found to be associated with higher fat and protein contents, as well as higher fat yield was highly frequent at 0.929, while its frequency in Butana x Holstein crossbred cattle was 0.394.	Lysine	99-105	diacylglycerol O-acyltransferase 1	Bos taurus	106-111
35332362-9	2022	The high frequency of the lysine DGAT1 protein variant K232 in Butana cattle could contribute to their high milk fat content in combination with low milk yield.	Lysine	26-32	diacylglycerol O-acyltransferase 1	Bos taurus	33-38
35328709-1	2022	Members of the lysyl oxidase (LOX) family catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-links, an essential process for connective tissue maturation.	Lysine	80-86	lysyl oxidase	Homo sapiens	15-28
35328709-1	2022	Members of the lysyl oxidase (LOX) family catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-links, an essential process for connective tissue maturation.	Lysine	80-86	lysyl oxidase	Homo sapiens	30-33
35328709-1	2022	Members of the lysyl oxidase (LOX) family catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin in the initiation step of the formation of covalent cross-links, an essential process for connective tissue maturation.	Lysine	80-86	elastin	Homo sapiens	130-137
35218667-8	2022	Depending on the RING domain, TRIM65 ubiquitinated and degraded the TPIT protein at multiple Lys sites.	Lysine	93-96	tripartite motif-containing 65	Mus musculus	30-36
35210408-5	2022	Mechanistically, PDPK1 (3-phosphoinositide-dependent protein-kinase 1) was identified as a novel SUMOylation substrate, which occurred predominantly at lysine 299 (K299) located within the protein-kinase domain.	Lysine	152-158	3-phosphoinositide dependent protein kinase 1	Homo sapiens	17-22
35210408-5	2022	Mechanistically, PDPK1 (3-phosphoinositide-dependent protein-kinase 1) was identified as a novel SUMOylation substrate, which occurred predominantly at lysine 299 (K299) located within the protein-kinase domain.	Lysine	152-158	3-phosphoinositide dependent protein kinase 1	Homo sapiens	24-69
35061896-4	2022	We found that topoisomerase 1-binding arginine/serine-rich protein (TOPORS) induces the SUMOylation of RAD51 at lysine residues 57 and 70 in response to DNA damaging agents.	Lysine	112-118	RAD51 recombinase	Homo sapiens	103-108
35204825-8	2022	The p53 complexes with SIRT2, MUL1, USP7, TXN, PIN1 and PPIF control regulation of p53 function through post-translational modifications, such as lysine acetylation or ubiquitination, cysteine/cystine redox transformation and peptidyl-prolyl cis-trans isomerization.	Lysine	146-152	ubiquitin specific peptidase 7	Homo sapiens	36-40
35434453-2	2022	Trimethylation of lysine 27 of histone H3 at the cis-regulatory element of Hhex was maintained and that of lysine 4 was reduced during receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclastogenesis, which was associated with a reduction of Hhex expression.	Lysine	18-24	H3 clustered histone 7	Mus musculus	31-41
35172032-0	2022	Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis.	Lysine	94-100	K(lysine) acetyltransferase 2A	Mus musculus	160-164
34654054-4	2022	We focus on KAT2A, a lysine acetyltransferase responsible for Histone 3 Lysine 9 acetylation, which we recently identified as a dependence in Acute Myeloid Leukemia stem cells, and that participates in 2 distinct macromolecular complexes: Ada Two-A-Containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA).	Lysine	21-27	lysine acetyltransferase 2A	Homo sapiens	12-17
34654054-4	2022	We focus on KAT2A, a lysine acetyltransferase responsible for Histone 3 Lysine 9 acetylation, which we recently identified as a dependence in Acute Myeloid Leukemia stem cells, and that participates in 2 distinct macromolecular complexes: Ada Two-A-Containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA).	Lysine	72-78	lysine acetyltransferase 2A	Homo sapiens	12-17